locus-tag class description BZ167_00005 ENOG4105C0W non-ribosomal peptide synthetase BZ167_00010 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_00020 ENOG4106U2H Protein of unknown function (DUF1360) BZ167_00025 ENOG4105F32 YngK protein BZ167_00030 ENOG4105C1G acyl-Coa dehydrogenase BZ167_00035 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_00040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BZ167_00045 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BZ167_00050 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BZ167_00055 ENOG4105E39 Enoyl-CoA hydratase BZ167_00060 ENOG4107QX3 carboxylase BZ167_00065 ENOG4107T5V SNARE associated Golgi BZ167_00070 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BZ167_00080 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) BZ167_00085 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BZ167_00090 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BZ167_00095 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BZ167_00100 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BZ167_00105 ENOG4106A3M Cytochrome p-450 BZ167_00110 ENOG4105CY2 Citrate transporter BZ167_00115 ENOG4105D6N CoA-transferase, subunit a BZ167_00120 ENOG4108IIH CoA-transferase subunit B BZ167_00155 ENOG4107SYN Glycosyl hydrolases family 43 BZ167_00165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZ167_00200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BZ167_00255 ENOG4105FVX BZ167_00270 ENOG4108I5G Major Facilitator superfamily BZ167_00280 ENOG4105DMW Dehydrogenase reductase BZ167_00285 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BZ167_00290 ENOG4108UHU Aldolase BZ167_00295 ENOG4105CPQ Dehydrogenase BZ167_00320 ENOG4105DQ6 Transposase BZ167_00330 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BZ167_00335 ENOG4105K4P CoA-binding domain protein BZ167_00340 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BZ167_00345 ENOG4105W8X HesB YadR YfhF-family protein BZ167_00350 ENOG4105MI2 BZ167_00360 ENOG41067CD Small, acid-soluble spore protein Tlp BZ167_00375 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BZ167_00380 ENOG4108I0Z Aconitate hydratase BZ167_00415 ENOG4107QIV Cytochrome c biogenesis protein BZ167_00425 ENOG4105VXM UPF0154 protein BZ167_00435 ENOG4105CV1 Transketolase (EC 2.2.1.1) BZ167_00440 ENOG4105VPS UPF0291 protein BZ167_00445 ENOG4108SVB resolvase BZ167_00455 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BZ167_00475 ENOG4105K7W phage-related replication protein BZ167_00500 ENOG41068WN BZ167_00510 ENOG4108M1A Chitin-binding protein BZ167_00530 ENOG4105EPI acetyltransferase, (GNAT) family BZ167_00550 ENOG4105DQ4 alcohol dehydrogenase BZ167_00555 ENOG4105SF0 DinB family BZ167_00580 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BZ167_00585 ENOG4105CMG Carbohydrate kinase BZ167_00590 ENOG4105C93 Xylose Isomerase BZ167_00600 ENOG4105DSG hydrolase family 43 BZ167_00605 ENOG4105CT4 transporter BZ167_00620 ENOG4106ANW SMI1_KNR4 BZ167_00625 ENOG4106BHF BZ167_00645 ENOG4105C5F glutamine synthetase BZ167_00650 ENOG4105KV4 Transcriptional regulator BZ167_00655 ENOG4105CXI aluminum resistance protein BZ167_00660 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BZ167_00665 ENOG4106F1P AAA ATPase, central domain protein BZ167_00675 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BZ167_00680 ENOG4105U6W MutT NUDIX family protein BZ167_00685 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BZ167_00690 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BZ167_00715 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BZ167_00740 ENOG4108X3M OsmC Ohr family protein BZ167_00745 ENOG4105K7W phage-related replication protein BZ167_00755 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BZ167_00765 ENOG4105XPP Protein of unknown function (DUF1275) BZ167_00770 ENOG4105WFK nuclease BZ167_00775 ENOG4106A3M Cytochrome p-450 BZ167_00785 ENOG4105C0W non-ribosomal peptide synthetase BZ167_00795 ENOG4107SQU synthase BZ167_00800 ENOG4105C0W non-ribosomal peptide synthetase BZ167_00805 ENOG4108KQ6 Enoyl-CoA hydratase BZ167_00810 ENOG4108MGH Enoyl-CoA hydratase BZ167_00815 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BZ167_00820 ENOG41062T2 Acyl carrier protein BZ167_00825 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BZ167_00830 ENOG4108JA1 polyketide synthase BZ167_00835 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BZ167_00840 ENOG4108151 Beta-lactamase domain protein BZ167_00855 ENOG4105DQ6 Transposase BZ167_00880 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BZ167_00900 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BZ167_00905 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BZ167_00910 ENOG4105CPQ Dehydrogenase BZ167_00915 ENOG4105MCT stage V sporulation protein S BZ167_00920 ENOG4105D48 metallophosphoesterase BZ167_00930 ENOG4108A04 Beta-lactamase BZ167_00935 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BZ167_00940 ENOG4105CEV competence damage-inducible protein BZ167_00945 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BZ167_00960 ENOG4105XZV Protein of unknown function (DUF3243) BZ167_00965 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BZ167_00980 ENOG4105EYF MMPL domain protein BZ167_00995 ENOG4105FDP GntR family transcriptional regulator BZ167_01000 ENOG4105CNU cell division protein FtsK BZ167_01010 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BZ167_01020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BZ167_01030 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BZ167_01035 ENOG4108S0H Dipicolinic acid synthetase, b subunit BZ167_01040 ENOG4105E35 Dipicolinate synthase subunit A BZ167_01050 ENOG4105C1V Peptidase, M16 BZ167_01060 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BZ167_01065 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BZ167_01070 ENOG4105DTN riboflavin biosynthesis protein ribF BZ167_01075 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BZ167_01080 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BZ167_01085 ENOG4105W7A Protein of unknown function (DUF503) BZ167_01090 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BZ167_01095 ENOG4105VHM ribosomal protein BZ167_01100 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BZ167_01105 ENOG4105CHV Transcription elongation factor NusA BZ167_01110 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BZ167_01115 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BZ167_01120 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BZ167_01125 ENOG4105DZP Membrane-associated zinc metalloprotease BZ167_01135 ENOG4105KNE Phosphatidate cytidylyltransferase BZ167_01140 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BZ167_01145 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BZ167_01150 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BZ167_01160 ENOG4105CE9 30S ribosomal protein S2 BZ167_01170 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZ167_01175 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BZ167_01185 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BZ167_01190 ENOG4105CBS Chea signal transduction histidine kinase BZ167_01195 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BZ167_01205 ENOG4105FZW flagellar biosynthesis regulator FlhF BZ167_01210 ENOG4105D7B Flagellar biosynthesis protein flha BZ167_01215 ENOG4105D00 flagellar biosynthetic protein flhB BZ167_01220 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BZ167_01225 ENOG4105VS8 Flagellar biosynthetic protein fliq BZ167_01230 ENOG4105CN7 Flagellar biosynthetic protein FliP BZ167_01240 ENOG4107YTP response regulator receiver protein BZ167_01245 ENOG4105DD5 Flagellar motor switch protein BZ167_01250 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BZ167_01260 ENOG41068WV flagellar FlbD family protein BZ167_01265 ENOG4108JQA flagellar BZ167_01270 ENOG410822I Flagellar hook capping protein BZ167_01275 ENOG410696Y Flagellar hook-length control protein BZ167_01285 ENOG4106YF4 Flagellar biosynthesis chaperone BZ167_01300 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BZ167_01305 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BZ167_01310 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BZ167_01315 ENOG4108ZC9 flagellar basal-body rod protein flgc BZ167_01320 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BZ167_01330 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BZ167_01335 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BZ167_01340 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BZ167_01345 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BZ167_01350 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BZ167_01355 ENOG4105C79 DNA protecting protein DprA BZ167_01360 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BZ167_01365 ENOG4105CMV Succinyl-CoA synthetase subunit beta BZ167_01370 ENOG4105VM1 flagellar BZ167_01380 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BZ167_01385 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BZ167_01390 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BZ167_01395 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BZ167_01410 ENOG4108BW8 UPF0109 protein BZ167_01415 ENOG4105K5M 30s ribosomal protein S16 BZ167_01425 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BZ167_01435 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BZ167_01440 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BZ167_01445 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BZ167_01450 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BZ167_01455 ENOG4105CHR reductase BZ167_01460 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BZ167_01465 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BZ167_01470 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BZ167_01475 ENOG4105CB5 ATP-dependent DNA helicase recG BZ167_01480 ENOG4105EJQ L-serine dehydratase BZ167_01490 ENOG4105DP4 dak2 domain fusion protein ylov BZ167_01495 ENOG4108ZAA Alkaline-shock protein BZ167_01500 ENOG4105VB9 50S ribosomal protein l28 BZ167_01510 ENOG4105FJ0 thiamine BZ167_01515 ENOG4105DJV ribulose-phosphate 3-epimerase BZ167_01520 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BZ167_01525 ENOG4105D9P serine threonine protein kinase BZ167_01530 ENOG4108ZF3 Phosphatase BZ167_01535 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BZ167_01540 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BZ167_01545 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BZ167_01550 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BZ167_01555 ENOG4105C25 Primosomal protein n' BZ167_01560 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BZ167_01570 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BZ167_01575 ENOG4105KC4 UPF0296 protein BZ167_01580 ENOG4105DSJ YicC domain protein BZ167_01590 ENOG4105F23 Fibronectin-binding protein BZ167_01600 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BZ167_01605 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BZ167_01610 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BZ167_01620 ENOG4107RIQ Sulfate adenylate transferase BZ167_01635 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BZ167_01640 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BZ167_01645 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BZ167_01650 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BZ167_01655 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BZ167_01660 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BZ167_01670 ENOG4105CXT aspartate transcarbamylase BZ167_01680 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BZ167_01685 ENOG4105C34 Pseudouridine synthase BZ167_01690 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BZ167_01700 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BZ167_01715 ENOG4105DBK s4 domain protein BZ167_01720 ENOG41067XK integral membrane protein BZ167_01725 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BZ167_01730 ENOG4105DFA alanine racemase domain protein BZ167_01735 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BZ167_01740 ENOG4105WR5 sporulation protein, YlmC YmxH family BZ167_01750 ENOG4105DKW ABC transporter BZ167_01760 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZ167_01765 ENOG4105FFI sigma-e processing peptidase spoiiga BZ167_01775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BZ167_01780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BZ167_01785 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BZ167_01790 ENOG4105D4A Cell wall formation (By similarity) BZ167_01795 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BZ167_01800 ENOG4105CNI cell division protein FtsW BZ167_01805 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BZ167_01810 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BZ167_01815 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BZ167_01820 ENOG4105CJN penicillin-binding protein BZ167_01825 ENOG4105CJN penicillin-binding protein BZ167_01835 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BZ167_01840 ENOG4108V6E Cell division protein mraZ BZ167_01865 ENOG41067VY 50S ribosomal protein L32 BZ167_01870 ENOG4105KNH Nucleic acid-binding protein BZ167_01875 ENOG4105CDE UPF0348 protein BZ167_01880 ENOG41063PX domain protein BZ167_01885 ENOG4105D78 K07001 NTE family protein BZ167_01890 ENOG4105H20 Sporulation integral membrane protein YlbJ BZ167_01895 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BZ167_01900 ENOG4106H78 methyltransferase BZ167_01925 ENOG4106UY4 Inherit from COG: Scp-like extracellular BZ167_01930 ENOG41080XQ Signal transduction protein with cbs domains BZ167_01945 ENOG41064X9 cytochrome C oxidase subunit IV BZ167_01950 ENOG4105CCU oxidase (Subunit III) BZ167_01955 ENOG4105BZ9 Cytochrome C oxidase, subunit I BZ167_01965 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BZ167_01975 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BZ167_01980 ENOG4105CNI cell division protein FtsW BZ167_01990 ENOG4105CSV Glutaminase BZ167_02000 ENOG4108IAB Phoh family BZ167_02015 ENOG4105QA2 BZ167_02020 ENOG4105CI3 gtp-binding protein typa BZ167_02055 ENOG4105D4Y metalloprotease BZ167_02065 ENOG4105ECY inositol monophosphatase BZ167_02085 ENOG4105WBI UPF0223 protein BZ167_02090 ENOG4105CXN decarboxylase BZ167_02110 ENOG4107QN2 dihydrolipoyl dehydrogenase BZ167_02115 ENOG4105C7S Dehydrogenase BZ167_02120 ENOG4105CPP Dehydrogenase, E1 component BZ167_02130 ENOG4105FQP Beta-lactamase BZ167_02135 ENOG4105C0W non-ribosomal peptide synthetase BZ167_02140 ENOG4107SQU synthase BZ167_02145 ENOG4107SQU synthase BZ167_02150 ENOG4105C0W non-ribosomal peptide synthetase BZ167_02155 ENOG4105C0W non-ribosomal peptide synthetase BZ167_02160 ENOG4107SQU synthase BZ167_02165 ENOG4105C0W non-ribosomal peptide synthetase BZ167_02170 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BZ167_02190 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BZ167_02195 ENOG4108X4Q Hydrolase BZ167_02205 ENOG4106148 UPF0356 protein BZ167_02210 ENOG4105CN5 Metallo-Beta-Lactamase BZ167_02215 ENOG4105CPN adenine deaminase BZ167_02220 ENOG4107ZYR domain protein BZ167_02230 ENOG4105BZU Histidine kinase BZ167_02255 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BZ167_02260 ENOG4105C5H ABC transporter BZ167_02275 ENOG4105DM4 PTS System BZ167_02280 ENOG4105DE4 1-phosphofructokinase BZ167_02285 ENOG4105E98 transcriptional regulator DeoR family BZ167_02290 ENOG4107RBB ABC transporter, permease BZ167_02295 ENOG4105C19 ABC transporter BZ167_02300 ENOG4107X8C Efflux transporter RND family MFP subunit BZ167_02310 ENOG41067WU Molybdopterin converting factor (Subunit 1) BZ167_02315 ENOG4108ZAF Molybdopterin BZ167_02320 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BZ167_02325 ENOG4105CVM Molybdenum cofactor synthesis domain protein BZ167_02330 ENOG4105D06 uba thif-type nad fad binding protein BZ167_02335 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BZ167_02350 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BZ167_02355 ENOG4105D8X mechanosensitive ion channel BZ167_02380 ENOG4105NQC Flavodoxin BZ167_02410 ENOG4108XRC Protein of unknown function (DUF458) BZ167_02415 ENOG4107IN1 Protein of unknown function (DUF1797) BZ167_02420 ENOG4105EPM Diguanylate phosphodiesterase BZ167_02430 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BZ167_02440 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BZ167_02450 ENOG4105UIN BZ167_02455 ENOG4107R88 Chemotaxis protein (CheV) BZ167_02465 ENOG4105CHM Aminotransferase BZ167_02470 ENOG4105BZU Histidine kinase BZ167_02480 ENOG4105K4I Scp-like extracellular BZ167_02485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BZ167_02490 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BZ167_02495 ENOG4105F6S Spore photoproduct lyase BZ167_02505 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BZ167_02510 ENOG4105KRI phosphocarrier protein (HPr BZ167_02520 ENOG4105CID antiterminator BZ167_02530 ENOG4105DC7 peptidase M24 BZ167_02535 ENOG4105C59 p-type ATPase BZ167_02550 ENOG4105F0V Cell wall hydrolase BZ167_02580 ENOG4105FEA Spore maturation protein BZ167_02590 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BZ167_02600 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BZ167_02605 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BZ167_02610 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BZ167_02615 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BZ167_02625 ENOG4108K88 Membrane BZ167_02640 ENOG4105E14 MotA TolQ exbB proton channel BZ167_02645 ENOG4105ER2 Ompa motb domain protein BZ167_02650 ENOG41090MY MarR family Transcriptional regulator BZ167_02655 ENOG4105BZU Histidine kinase BZ167_02665 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BZ167_02670 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BZ167_02675 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BZ167_02680 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BZ167_02690 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BZ167_02700 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BZ167_02705 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BZ167_02710 ENOG4105BZU Histidine kinase BZ167_02715 ENOG4108TGC Acyltransferase BZ167_02720 ENOG410900G Protein of unknown function (DUF421) BZ167_02730 ENOG4105DQ6 Transposase BZ167_02740 ENOG4105D0M Protease HtpX homolog BZ167_02750 ENOG410681C small acid-soluble spore protein BZ167_02760 ENOG4108WZW RNA polymerase sigma BZ167_02765 ENOG4107TS3 membrane protein, TerC BZ167_02770 ENOG4107T5V SNARE associated Golgi BZ167_02775 ENOG4105FDF Could be involved in DNA repair (By similarity) BZ167_02780 ENOG4105DQE DNA ligase BZ167_02800 ENOG4105V75 Transcriptional regulator BZ167_02805 ENOG4105CJW magnesium transporter BZ167_02820 ENOG4105VRS hydrolase family 18 BZ167_02825 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BZ167_02830 ENOG4108JJB ABC transporter BZ167_02835 ENOG4108W7F transporter, permease BZ167_02845 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BZ167_02850 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BZ167_02855 ENOG4108Y4K DNA-binding transcriptional activator BZ167_02860 ENOG4105D8G Major Facilitator superfamily BZ167_02870 ENOG4107TVC Glycosyl transferase, family 2 BZ167_02885 ENOG4108ZHJ Organic hydroperoxide resistance protein BZ167_02890 ENOG4105K56 Transcriptional regulator BZ167_02905 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BZ167_02910 ENOG4105CIY formyltetrahydrofolate deformylase BZ167_02915 ENOG41080TC multidrug resistance protein BZ167_02925 ENOG4108428 Inherit from COG: -acetyltransferase BZ167_02930 ENOG4108S4H thioesterase Superfamily protein BZ167_02935 ENOG4107TUM Amidinotransferase BZ167_02940 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BZ167_02945 ENOG4108JQ7 (ABC) transporter BZ167_02950 ENOG4107SN7 NLP P60 protein BZ167_02955 ENOG4105DTQ mandelate racemase muconate lactonizing BZ167_02960 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BZ167_02970 ENOG4105C3U ABC transporter BZ167_02975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZ167_02980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BZ167_02985 ENOG4108ME1 Peptidase M55 D-aminopeptidase BZ167_02995 ENOG4105C0H protease BZ167_03000 ENOG4105CKK Glycosyl transferase, family 2 BZ167_03005 ENOG4105EDW glycosyl transferase, family 39 BZ167_03015 ENOG4107R7I amino acid BZ167_03020 ENOG4107GRR phosphate transport regulator BZ167_03025 ENOG4105CJ3 phosphate transporter BZ167_03040 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BZ167_03070 ENOG41068G1 BZ167_03080 ENOG410906S phage-like element pbsx protein xkdt BZ167_03085 ENOG41066EA baseplate J family protein BZ167_03090 ENOG4105MFU Protein of unknown function (DUF2634) BZ167_03100 ENOG4105X7F BZ167_03105 ENOG4108WZM domain protein BZ167_03110 ENOG4108FKH Transglycosylase SLT domain BZ167_03110 ENOG4108FKH Transglycosylase SLT domain BZ167_03110 ENOG4108FKH Transglycosylase SLT domain BZ167_03115 ENOG4105MTC XkdN-like protein BZ167_03120 ENOG4105FR7 XkdM protein, phage-like element PBSX BZ167_03125 ENOG4105PQS phage protein BZ167_03140 ENOG41060SN BZ167_03165 ENOG4108MDF Phage Portal Protein BZ167_03170 ENOG4105IG6 Phage terminase, large subunit BZ167_03175 ENOG4108TFU terminase (Small subunit) BZ167_03220 ENOG410635T phage-like element pbsx protein BZ167_03225 ENOG4105WEF catalase BZ167_03230 ENOG4105K7W phage-related replication protein BZ167_03235 ENOG4105KWG Pfam:DUF1696 BZ167_03240 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BZ167_03255 ENOG4107TSN permease BZ167_03265 ENOG4105DQ6 Transposase BZ167_03280 ENOG4105F3H Histidine kinase BZ167_03290 ENOG4105CTX dehydratase BZ167_03295 ENOG4107QZW Altronate oxidoreductase BZ167_03300 ENOG4107KJX Transcriptional regulator BZ167_03305 ENOG4105CT4 transporter BZ167_03310 ENOG4105D2H Uronic isomerase BZ167_03325 ENOG4105Q95 Cupin 2, conserved barrel domain protein BZ167_03335 ENOG4108IXI (ABC) transporter BZ167_03340 ENOG4105C4B ABC transporter, permease BZ167_03345 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BZ167_03355 ENOG41087PP glycosyltransferase MGT family BZ167_03360 ENOG4106A3M Cytochrome p-450 BZ167_03370 ENOG4108IEG Formate dehydrogenase Alpha subunit BZ167_03395 ENOG4105KT7 mgtC SapB transporter BZ167_03420 ENOG4105E98 transcriptional regulator DeoR family BZ167_03430 ENOG4105VCP PTS System BZ167_03435 ENOG4105CK1 PTS System BZ167_03440 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BZ167_03445 ENOG4105CMR udp-glucose 4-epimerase BZ167_03450 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BZ167_03465 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZ167_03490 ENOG410907G BZ167_03495 ENOG4107YU2 histidine triad (hIT) protein BZ167_03580 ENOG4106BHF BZ167_03615 ENOG4105C28 cystathionine BZ167_03620 ENOG4105C28 cystathionine BZ167_03630 ENOG4108ZMI UPF0477 protein BZ167_03645 ENOG4105CJ1 ABC, transporter BZ167_03665 ENOG4105ENA helicase BZ167_03715 ENOG4107A88 BZ167_03720 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BZ167_03725 ENOG4105DWF phosphomethylpyrimidine kinase BZ167_03730 ENOG4105D06 uba thif-type nad fad binding protein BZ167_03750 ENOG4108VEU Thiamine monophosphate synthase BZ167_03755 ENOG4105ETU transcriptional activator (TenA BZ167_03770 ENOG4107S1Q Phosphatase BZ167_03775 ENOG4105EMS pseudouridine synthase BZ167_03780 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BZ167_03795 ENOG4105MIX Adenylate cyclase BZ167_03800 ENOG4105E4C Lytic transglycosylase catalytic BZ167_03805 ENOG4108Z18 K06886 hemoglobin BZ167_03810 ENOG4105T58 Dithiol-disulfide isomerase BZ167_03815 ENOG4105DPN Oligoendopeptidase f BZ167_03825 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BZ167_03830 ENOG4108ZCF integral membrane protein BZ167_03835 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BZ167_03850 ENOG4108JQ7 (ABC) transporter BZ167_03860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZ167_03865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BZ167_03870 ENOG4108J59 Extracellular solute-binding protein, family 5 BZ167_03880 ENOG4105C31 Tryptophanyl-tRNA synthetase BZ167_03890 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZ167_03905 ENOG4108JQ7 (ABC) transporter BZ167_03910 ENOG4105C3U ABC transporter BZ167_03920 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BZ167_03925 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BZ167_03940 ENOG4107RMD Basic membrane lipoprotein BZ167_03970 ENOG4105DBV ornithine carbamoyltransferase BZ167_03980 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BZ167_03985 ENOG4105C8Y Acetylornithine aminotransferase BZ167_03990 ENOG4105CAS nag kinase BZ167_04000 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BZ167_04010 ENOG4105IQ5 FAD linked oxidase domain protein BZ167_04015 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BZ167_04020 ENOG4105VG1 fes assembly suf system protein BZ167_04025 ENOG4108MXZ Esterase BZ167_04030 ENOG4108KP7 hydrolase BZ167_04035 ENOG41073B9 BZ167_04045 ENOG4107AYK membrAne BZ167_04050 ENOG4105EPR degv family BZ167_04055 ENOG4107E6A Cytochrome p-450 BZ167_04060 ENOG4105C8Q Methyl-accepting chemotaxis BZ167_04065 ENOG4105DIH basic membrane BZ167_04070 ENOG4105QNR S1 RNA binding domain protein BZ167_04075 ENOG4108VPT UPF0234 protein BZ167_04085 ENOG4105MA6 gCN5-related N-acetyltransferase BZ167_04090 ENOG4105MYW Pentapeptide repeat protein BZ167_04095 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BZ167_04100 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BZ167_04105 ENOG4105SF0 DinB family BZ167_04110 ENOG4106HBX Transcriptional Regulator AraC Family BZ167_04115 ENOG4105UQX Mate efflux family protein BZ167_04125 ENOG4105CAQ asparagine synthetase BZ167_04140 ENOG4105ERH Fumarylacetoacetate hydrolase BZ167_04185 ENOG4105EYH Exonuclease BZ167_04195 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BZ167_04200 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BZ167_04215 ENOG4108IG5 Transcriptional regulator BZ167_04225 ENOG4108KK1 membrane protein AbrB duplication BZ167_04230 ENOG4108INS Transcriptional regulator BZ167_04235 ENOG4107SCK Monooxygenase BZ167_04250 ENOG41060YP BZ167_04255 ENOG4106CAD Protein of unknown function (DUF3311) BZ167_04260 ENOG4105E1V na solute symporter BZ167_04265 ENOG4105K8R UPF0145 protein BZ167_04270 ENOG4105X3H Excalibur domain protein BZ167_04285 ENOG4108ZMX Domain of unknown function (DU1801) BZ167_04295 ENOG4105XVF Competence transcription factor BZ167_04315 ENOG4106YBV Methyl-accepting chemotaxis BZ167_04320 ENOG4107ZYJ bioY protein BZ167_04325 ENOG4107F3J Amp-dependent synthetase and ligase BZ167_04335 ENOG4107TB6 phosphoglycerate mutase BZ167_04340 ENOG4108HUF Transporter BZ167_04355 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BZ167_04365 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_04375 ENOG4105DF9 Lipoate-protein, ligase BZ167_04380 ENOG4108RQ5 Beta-lactamase domain-containing protein BZ167_04385 ENOG4106AXD BZ167_04395 ENOG4105DER m42 family BZ167_04410 ENOG4105ECB domain protein BZ167_04420 ENOG4105C1Q protoporphyrinogen oxidase BZ167_04425 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BZ167_04430 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BZ167_04435 ENOG4105BZ4 penicillin-binding protein BZ167_04440 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BZ167_04470 ENOG4105K59 histidine triad (HIT) protein BZ167_04475 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BZ167_04480 ENOG4105NBU tryptophan transport protein BZ167_04530 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BZ167_04540 ENOG4105EQI Metal Dependent Phosphohydrolase BZ167_04545 ENOG4106D4I domain protein BZ167_04550 ENOG4107VRP DNA repair exonuclease BZ167_04555 ENOG4105RHA ABC transporter, permease BZ167_04560 ENOG4108IUX (ABC) transporter BZ167_04570 ENOG4105CGU Enoyl-CoA hydratase BZ167_04580 ENOG4105NCW Trka-c domain protein BZ167_04585 ENOG4107S91 Sodium hydrogen exchanger BZ167_04595 ENOG4105D4P Coproporphyrinogen iii oxidase BZ167_04610 ENOG4105WZB UPF0342 protein BZ167_04615 ENOG4106MP8 UPF0754 membrane protein BZ167_04625 ENOG410839P BZ167_04650 ENOG4105BZ1 (ABC) transporter BZ167_04655 ENOG4105BZ1 (ABC) transporter BZ167_04665 ENOG4105IIP Membrane BZ167_04670 ENOG4105W1N transcriptional regulator BZ167_04675 ENOG4105F0I Aminotransferase BZ167_04680 ENOG4107VMI polysaccharide deacetylase BZ167_04685 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BZ167_04690 ENOG4105D64 Mechanosensitive ion channel BZ167_04695 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BZ167_04700 ENOG4105WMR Protein CrcB homolog BZ167_04710 ENOG4105C37 (CBS) domain BZ167_04715 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase BZ167_04720 ENOG4105CHM Aminotransferase BZ167_04730 ENOG4105C37 (CBS) domain BZ167_04735 ENOG4105F6E Acyl-transferase BZ167_04740 ENOG4108AEY RNA polymerase sigma factor BZ167_04745 ENOG4105J37 BZ167_04755 ENOG4105C8J )-transporter BZ167_04760 ENOG4105CUB amino acid BZ167_04765 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BZ167_04770 ENOG4105BZN citrate synthase BZ167_04785 ENOG4105G6Z alkaline phosphatase BZ167_04790 ENOG4105ED1 spovr family BZ167_04830 ENOG4105WH1 Two component transcriptional regulator luxr family BZ167_04845 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BZ167_04850 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BZ167_04860 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BZ167_04865 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BZ167_04870 ENOG4105DQ6 Transposase BZ167_04880 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BZ167_04885 ENOG4107YBY Hydrolase BZ167_04890 ENOG41080XP Cbs domain BZ167_04900 ENOG4108YBP pseudouridine synthase BZ167_04940 ENOG4105BZU Histidine kinase BZ167_04955 ENOG4105VEQ Cold shock protein BZ167_04960 ENOG4108TU7 Inherit from COG: (ABC) transporter BZ167_04965 ENOG4105CJ1 ABC, transporter BZ167_04970 ENOG4105CZV ABC transporter BZ167_04975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BZ167_04990 ENOG4105CS1 NAD(P)H quinone oxidoreductase BZ167_04995 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZ167_05000 ENOG4105CW7 secretion protein, HlyD family BZ167_05005 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BZ167_05020 ENOG4105CYN Serine protein kinase BZ167_05040 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BZ167_05050 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BZ167_05065 ENOG4105VZ8 Transcriptional regulator BZ167_05070 ENOG4107D63 BZ167_05075 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BZ167_05085 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BZ167_05090 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BZ167_05095 ENOG4105E2Y ABC, transporter BZ167_05115 ENOG4108JQ7 (ABC) transporter BZ167_05120 ENOG4105C3U ABC transporter BZ167_05125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BZ167_05135 ENOG4105DEF Extracellular solute-binding protein, family 5 BZ167_05145 ENOG4105DNP FAD linked oxidase domain protein BZ167_05150 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BZ167_05155 ENOG4105EC3 peptidase S51, dipeptidase E BZ167_05265 ENOG4105TUA UPF0295 protein BZ167_05270 ENOG4105G5W regulator Fur family BZ167_05275 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BZ167_05280 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BZ167_05285 ENOG4107NBY Membrane BZ167_05290 ENOG4105BZ1 (ABC) transporter BZ167_05310 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BZ167_05315 ENOG4106BXE BZ167_05320 ENOG4105CEN a g-specific adenine glycosylase BZ167_05325 ENOG41067AE Membrane-bound metal-dependent hydrolase BZ167_05330 ENOG4105EJV Membrane BZ167_05335 ENOG4105CKK Glycosyl transferase, family 2 BZ167_05340 ENOG4105D74 hydrolase BZ167_05345 ENOG4106AKJ BZ167_05365 ENOG4108TCS Glutamyl endopeptidase BZ167_05375 ENOG4105F27 Major Facilitator BZ167_05385 ENOG410902V Modulates RecA activity (By similarity) BZ167_05390 ENOG4105ECP epimerase BZ167_05405 ENOG4107Y03 Nitroreductase BZ167_05410 ENOG4105JAB phenazine biosynthesis protein, phzf family BZ167_05420 ENOG410834F Transcriptional regulator BZ167_05425 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZ167_05430 ENOG4108YYS metal-dependent hydrolase (By similarity) BZ167_05445 ENOG4105H93 Acyltransferase family BZ167_05450 ENOG4105DYS nad(p)h dehydrogenase (quinone) BZ167_05455 ENOG4105U3E Transcriptional regulator BZ167_05460 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BZ167_05470 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BZ167_05480 ENOG4105BZ1 (ABC) transporter BZ167_05485 ENOG4105BZ1 (ABC) transporter BZ167_05495 ENOG4105CI1 PTS System BZ167_05500 ENOG4108Q3X Transcriptional regulator BZ167_05505 ENOG4105F8D glycoside hydrolase family 4 BZ167_05515 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BZ167_05525 ENOG4107QKR Dehydrogenase BZ167_05535 ENOG4107RUY (E1 component), alpha subunit BZ167_05560 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BZ167_05570 ENOG4105D7N magnesium and cobalt transport protein CorA BZ167_05580 ENOG4106KE4 Dehydrogenase BZ167_05600 ENOG4105D8X mechanosensitive ion channel BZ167_05610 ENOG4105UPD Calcium Proton BZ167_05615 ENOG4108ISG Major Facilitator BZ167_05620 ENOG4107U9T Pfam:Ribonuclease_BN BZ167_05630 ENOG4105KJF protein tyrosine phosphatase BZ167_05645 ENOG4105FF2 Type I DHQase BZ167_05650 ENOG4105E2X shikimate dehydrogenase BZ167_05655 ENOG4105ETE Transcriptional regulator (LacI family BZ167_05660 ENOG4107RKG DJ-1/PfpI family BZ167_05665 ENOG4105CGH 5'-nucleotidase BZ167_05680 ENOG4108RCM Nitroreductase BZ167_05685 ENOG4107414 GntR family transcriptional regulator BZ167_05690 ENOG4105CG3 alpha amylase, catalytic region BZ167_05695 ENOG4105C5Y PTS System BZ167_05735 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BZ167_05750 ENOG4108RPX mosc domain containing protein BZ167_05755 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) BZ167_05780 ENOG4108MRH transcriptional regulatory protein BZ167_05800 ENOG4107QPK )-transporter BZ167_05805 ENOG4108J20 pectate lyase BZ167_05820 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BZ167_05830 ENOG4105FDU atp-dependent rna helicase BZ167_05835 ENOG4105C5H ABC transporter BZ167_05840 ENOG4105DXB Major Facilitator superfamily BZ167_05845 ENOG4107SWG transcriptional regulator MERR family BZ167_05850 ENOG4105C5H ABC transporter BZ167_05855 ENOG4107TVC Glycosyl transferase, family 2 BZ167_05860 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BZ167_05865 ENOG4105FKZ Methyl-accepting chemotaxis BZ167_05870 ENOG4105C26 Dehydrogenase BZ167_05875 ENOG4105CUB amino acid BZ167_05880 ENOG4105EU0 Major facilitator Superfamily BZ167_05885 ENOG41090R9 glycosyltransferase BZ167_05890 ENOG4107R51 Glycosyl transferase, family 2 BZ167_05895 ENOG41090R9 glycosyltransferase BZ167_05905 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BZ167_05910 ENOG4105E0M Sulfatase BZ167_05915 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BZ167_05920 ENOG4108R1P BZ167_05925 ENOG41061H0 Monooxygenase BZ167_05930 ENOG41082F9 transcriptional regulator BZ167_05935 ENOG4106I4J membrane BZ167_05960 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BZ167_05965 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BZ167_05970 ENOG4105H67 Protein of unknown function (DUF421) BZ167_05980 ENOG4105M18 -acetyltransferase BZ167_05985 ENOG4105WEF catalase BZ167_06005 ENOG4105CDY transcriptional regulatory protein BZ167_06030 ENOG4105CJ1 ABC, transporter BZ167_06040 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BZ167_06045 ENOG4105CBD Diacylglycerol kinase BZ167_06055 ENOG4108IG5 Transcriptional regulator BZ167_06060 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BZ167_06065 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BZ167_06070 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BZ167_06075 ENOG4105CK7 Sodium proline symporter BZ167_06080 ENOG4105KT7 mgtC SapB transporter BZ167_06085 ENOG4105CRN Aminoglycoside phosphotransferase BZ167_06095 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BZ167_06100 ENOG4105C4R Atp-dependent dna helicase BZ167_06115 ENOG4105CBC glutamate synthase BZ167_06120 ENOG4105KGF protein, YerC YecD BZ167_06125 ENOG4108R5T secreted protein BZ167_06140 ENOG4105C12 Phosphoribosylglycinamide synthetase BZ167_06145 ENOG4105DC1 bifunctional purine biosynthesis protein purh BZ167_06150 ENOG4108V3E phosphoribosylglycinamide formyltransferase BZ167_06155 ENOG4105CXB phosphoribosylaminoimidazole synthetase BZ167_06165 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BZ167_06170 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BZ167_06175 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BZ167_06180 ENOG4105C8V SAICAR synthetase BZ167_06185 ENOG4105C83 adenylosuccinate lyase BZ167_06190 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BZ167_06195 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BZ167_06220 ENOG4105C7N Xanthine uracil vitamin C permease BZ167_06240 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BZ167_06255 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BZ167_06265 ENOG4105C85 amino acid BZ167_06270 ENOG4107STQ Multicopper oxidase BZ167_06295 ENOG4105JVQ RNA Polymerase BZ167_06300 ENOG4108P49 AntiSigma factor BZ167_06305 ENOG4105EXC Acyl-transferase BZ167_06315 ENOG4108WV1 Pfam:DUF477 BZ167_06320 ENOG4105DQX Zinc finger domain BZ167_06325 ENOG41087YS Phage shock protein A BZ167_06340 ENOG4105CT4 transporter BZ167_06345 ENOG4105CPQ Dehydrogenase BZ167_06350 ENOG4105PGZ NB-ARC domain BZ167_06400 ENOG4108JJA ABC, transporter BZ167_06430 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BZ167_06440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZ167_06445 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BZ167_06450 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BZ167_06455 ENOG4108TYN CAAX amino terminal protease family protein BZ167_06465 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BZ167_06470 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BZ167_06475 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BZ167_06480 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BZ167_06485 ENOG4105C5H ABC transporter BZ167_06490 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BZ167_06495 ENOG410801F ribosomal-protein-alanine acetyltransferase BZ167_06500 ENOG41072GX Peptidase M22 Glycoprotease BZ167_06505 ENOG4105K8N protein family UPF0079, ATPase BZ167_06510 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BZ167_06550 ENOG4107QNK )-transporter BZ167_06570 ENOG4107QTZ amino acid BZ167_06590 ENOG4105DJ2 Major Facilitator Superfamily BZ167_06595 ENOG4105JXH GntR family transcriptional regulator BZ167_06600 ENOG4108TZY GntR Family Transcriptional Regulator BZ167_06605 ENOG4108SUT Major Facilitator Superfamily BZ167_06610 ENOG41090UD (LipO)protein BZ167_06615 ENOG4105FQP Beta-lactamase BZ167_06635 ENOG4105DRR Transcriptional regulator, GntR family BZ167_06655 ENOG4105F2W methyltransferase BZ167_06665 ENOG41090E6 transcriptional regulator MERR family BZ167_06685 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BZ167_06690 ENOG4105C2C drug resistance transporter, Bcr CflA BZ167_06700 ENOG4108JYZ YitT family BZ167_06720 ENOG4105EYF MMPL domain protein BZ167_06725 ENOG4108VB1 regulatoR BZ167_06730 ENOG4105ENE Histidine kinase BZ167_06740 ENOG4105PGS Spore coat protein BZ167_06745 ENOG4105E2A Dehydrogenase BZ167_06760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BZ167_06765 ENOG4105T38 integral membrane protein BZ167_06770 ENOG4108JGH Tetr family transcriptional regulator BZ167_06775 ENOG4105EQ0 Major Facilitator superfamily BZ167_06790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BZ167_06800 ENOG4105VUF Transcriptional regulator BZ167_06805 ENOG4105DQ4 alcohol dehydrogenase BZ167_06825 ENOG4105DWF phosphomethylpyrimidine kinase BZ167_06860 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BZ167_06870 ENOG4105H3G oxidoreductase BZ167_06875 ENOG4105PGM cation diffusion facilitator family transporter BZ167_06885 ENOG4105DNP FAD linked oxidase domain protein BZ167_06900 ENOG41082W1 Cupin 2, conserved barrel domain protein BZ167_06910 ENOG4105IRW patatin-like phospholipase family protein BZ167_06930 ENOG4108VJ1 Transcriptional regulator (CarD family BZ167_06935 ENOG4105VEQ Cold shock protein BZ167_06945 ENOG4108RYK Nad-dependent epimerase dehydratase BZ167_06950 ENOG4108Z40 Transcriptional regulator BZ167_06965 ENOG4108ZMQ domain protein BZ167_06975 ENOG4105K56 Transcriptional regulator BZ167_06980 ENOG4105CSH Transporter BZ167_06995 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BZ167_07035 ENOG4105K4H Nlp p60 protein BZ167_07045 ENOG4105P1M Domain of unknown function (DUF1874) BZ167_07085 ENOG4106128 DNA-binding helix-turn-helix protein BZ167_07090 ENOG4106BHR ftsk SpoIIIE family protein BZ167_07105 ENOG4108RYM conjugative transposon protein BZ167_07125 ENOG4108IMY Transcriptional regulator BZ167_07130 ENOG41068WC Domain of unknown function (DUF955) BZ167_07135 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BZ167_07175 ENOG410906U SprT-like BZ167_07185 ENOG41064BQ Phosphatase BZ167_07195 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BZ167_07200 ENOG4105WN5 stage II sporulation protein BZ167_07205 ENOG4107SGM protein serine threonine phosphatase BZ167_07210 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BZ167_07215 ENOG4105FUA antagonist BZ167_07220 ENOG4107MMM Anti-sigma-factor antagonist BZ167_07225 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BZ167_07235 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BZ167_07240 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BZ167_07245 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BZ167_07255 ENOG4105CKV Membrane BZ167_07260 ENOG410905X membrane-flanked domain protein BZ167_07265 ENOG4105C1J atp-dependent rna helicase BZ167_07270 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BZ167_07275 ENOG4105CPF Cell wall formation (By similarity) BZ167_07280 ENOG4105SZ6 Thioredoxin BZ167_07300 ENOG4105FDT acyl-CoA dehydrogenase BZ167_07315 ENOG4105CJ1 ABC, transporter BZ167_07320 ENOG4106F5Q Membrane BZ167_07325 ENOG4107QJT sodium dicarboxylate symporter BZ167_07330 ENOG4108MRH transcriptional regulatory protein BZ167_07335 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BZ167_07340 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BZ167_07355 ENOG41082W1 Cupin 2, conserved barrel domain protein BZ167_07360 ENOG4105QVS general stress protein BZ167_07365 ENOG4105EU9 BZ167_07370 ENOG4105KPY Small multidrug resistance protein BZ167_07375 ENOG4105RXJ BZ167_07380 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BZ167_07395 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BZ167_07435 ENOG4105C0X amino acid BZ167_07445 ENOG4107R8N Glycosyl transferase, family 2 BZ167_07450 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BZ167_07465 ENOG4105C9U ATP-dependent DNA helicase RecQ BZ167_07475 ENOG4105VCH membrane BZ167_07480 ENOG4105DQ6 Transposase BZ167_07495 ENOG410606W general stress protein BZ167_07510 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BZ167_07520 ENOG4105ETD TRANSCRIPTIONal BZ167_07525 ENOG4107QM2 Aldo Keto reductase BZ167_07530 ENOG4107RVG penicillin-binding protein BZ167_07535 ENOG41061CK Antibiotic biosynthesis monooxygenase BZ167_07545 ENOG4105XJB lipolytic protein G-D-S-L family BZ167_07550 ENOG4107258 Transcriptional regulator BZ167_07560 ENOG4105P4J Allophanate hydrolase, subunit 1 BZ167_07565 ENOG4105CFM UPF0317 protein BZ167_07570 ENOG4105C5A transporter BZ167_07575 ENOG4105E7W lamb ycsf family protein BZ167_07590 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BZ167_07610 ENOG4108ZYE Transcriptional regulator BZ167_07615 ENOG4108T5E Copper resistance protein BZ167_07620 ENOG4105KTB nuclear export factor GLE1 BZ167_07625 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BZ167_07635 ENOG4105C26 Dehydrogenase BZ167_07640 ENOG4108JPW Aminotransferase BZ167_07650 ENOG4105YVS arsR family transcriptional regulator BZ167_07655 ENOG41067V3 Antibiotic biosynthesis monooxygenase BZ167_07660 ENOG4108DBC nitroreductase BZ167_07665 ENOG4105R8C Transcriptional regulator BZ167_07680 ENOG4108IPW abc transporter atp-binding protein BZ167_07685 ENOG4105CM4 permease protein BZ167_07690 ENOG4105DHS permease protein BZ167_07695 ENOG4105CFH Aspartokinase BZ167_07715 ENOG4105BZU Histidine kinase BZ167_07720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZ167_07725 ENOG4107WD8 ABC transporter, permease BZ167_07735 ENOG4108PGP mmge prpd family protein BZ167_07740 ENOG4105CH2 amidohydrolase BZ167_07750 ENOG4108HW4 amino acid AbC transporter BZ167_07755 ENOG4105EAB amino acid AbC transporter BZ167_07760 ENOG4108XSB acetyltransferase, (GNAT) family BZ167_07765 ENOG4105CPU Monooxygenase BZ167_07780 ENOG4105E1K spore germination protein BZ167_07795 ENOG4105DUX Transporter BZ167_07800 ENOG41069ZX BZ167_07805 ENOG41069ZX BZ167_07810 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BZ167_07815 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BZ167_07820 ENOG4106P55 Transcriptional regulator BZ167_07830 ENOG4105DRP amino acid AbC transporter BZ167_07835 ENOG4105CDA abc transporter atp-binding protein BZ167_07855 ENOG4105SX7 Transporter BZ167_07865 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BZ167_07885 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_07895 ENOG4105KVH Transcriptional regulator BZ167_07900 ENOG4108VA3 3-hexulose-6-phosphate synthase BZ167_07905 ENOG41080HJ 6-phospho 3-hexuloisomerase BZ167_07920 ENOG4105CS2 ec 3.2.1.21 BZ167_07930 ENOG4105DQ6 Transposase BZ167_07940 ENOG4105HHM rdd domain containing protein BZ167_07945 ENOG4105E2A Dehydrogenase BZ167_07950 ENOG4105CKI cobalamin synthesis protein BZ167_07965 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BZ167_07970 ENOG4108IFG nitrite reductase, (NAD(P)H) BZ167_07975 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BZ167_07980 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BZ167_07985 ENOG4105CAY ferredoxin--nadp reductase BZ167_07990 ENOG4107YHD transcriptional regulator BZ167_07995 ENOG4105CK7 Sodium proline symporter BZ167_08000 ENOG4105C26 Dehydrogenase BZ167_08010 ENOG410756H nucleotidyltransferase BZ167_08015 ENOG4105I82 acetyl xylan esterase BZ167_08020 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BZ167_08025 ENOG4105DJB Major Facilitator Superfamily BZ167_08030 ENOG4108WBH protein TIM barrel BZ167_08035 ENOG4105I1F Resistance protein BZ167_08045 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BZ167_08050 ENOG4105EIG urea carboxylase-associated protein 1 BZ167_08080 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BZ167_08110 ENOG4107SQ8 Glycine betaine BZ167_08115 ENOG4108IJ7 Glycine betaine BZ167_08120 ENOG41079KZ Major Facilitator Superfamily BZ167_08130 ENOG4108TTB tellurium resistance protein BZ167_08135 ENOG4107TS3 membrane protein, TerC BZ167_08140 ENOG4106FN3 tellurium resistance protein BZ167_08145 ENOG4106FN3 tellurium resistance protein BZ167_08150 ENOG4108N0M stress protein BZ167_08155 ENOG4105DEN Luciferase family BZ167_08165 ENOG4105DIK (ABC) transporter BZ167_08170 ENOG4105DSE periplasmic solute binding protein BZ167_08180 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BZ167_08210 ENOG4107SET aldo keto reductase BZ167_08215 ENOG41060AI SEC-C motif BZ167_08220 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BZ167_08225 ENOG4107RB3 L-asparaginase BZ167_08230 ENOG4105J7D transcriptional regulator BZ167_08235 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZ167_08240 ENOG4107EPV Aminotransferase class V BZ167_08245 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BZ167_08250 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BZ167_08255 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BZ167_08260 ENOG4105DGI Alkaline phosphatase BZ167_08285 ENOG4105XXY Thioredoxin BZ167_08290 ENOG4108VGI doxx family BZ167_08295 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BZ167_08300 ENOG4108TVJ Nitroreductase BZ167_08305 ENOG41076HS cation diffusion facilitator family transporter BZ167_08335 ENOG4105CSV Glutaminase BZ167_08345 ENOG4108J5H Homocysteine s-methyltransferase BZ167_08350 ENOG4108IQI permease BZ167_08355 ENOG4105CM2 brancheD-chain amino acid aminotransferase BZ167_08365 ENOG4105C72 UPF0176 protein BZ167_08380 ENOG4107ZTW SNARE associated Golgi BZ167_08385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BZ167_08390 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BZ167_08395 ENOG4107SCQ Iron-containing alcohol dehydrogenase BZ167_08435 ENOG4105CXY transporter BZ167_08440 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BZ167_08450 ENOG4107QTZ amino acid BZ167_08465 ENOG4106DDH Sporulation-specific SASP protein BZ167_08490 ENOG4105C0W non-ribosomal peptide synthetase BZ167_08495 ENOG4105C0W non-ribosomal peptide synthetase BZ167_08535 ENOG4105CJ1 ABC, transporter BZ167_08540 ENOG4105WH1 Two component transcriptional regulator luxr family BZ167_08545 ENOG4105BZU Histidine kinase BZ167_08560 ENOG41061AU MarR family Transcriptional regulator BZ167_08570 ENOG41067MG lrgb family BZ167_08580 ENOG4106K80 BZ167_08605 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BZ167_08610 ENOG4107U5W ybbr family BZ167_08615 ENOG4105C8B TIGR00159 family BZ167_08625 ENOG4105EMN RNA polymerase sigma factor BZ167_08655 ENOG4105EWC Purine nucleoside phosphorylase BZ167_08665 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BZ167_08680 ENOG4105D17 glycoside hydrolase, family 3 domain protein BZ167_08685 ENOG4105EHZ conserved protein UCP016719 BZ167_08690 ENOG410874W AraC family transcriptional regulator BZ167_08710 ENOG4108SA1 esterase BZ167_08720 ENOG4105CHH sulfate transporter BZ167_08735 ENOG4108JPW Aminotransferase BZ167_08800 ENOG4108NMV polysaccharide deacetylase BZ167_08815 ENOG4105D1F ATP-binding protein BZ167_08835 ENOG4108I0C methyltransferase BZ167_08840 ENOG4108UJD 30S ribosomal protein S9 BZ167_08845 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BZ167_08850 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BZ167_08855 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BZ167_08860 ENOG4108JJB ABC transporter BZ167_08865 ENOG4108JJB ABC transporter BZ167_08870 ENOG4108ZT0 50S ribosomal protein l17 BZ167_08875 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BZ167_08880 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BZ167_08885 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BZ167_08895 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BZ167_08905 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BZ167_08910 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BZ167_08915 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BZ167_08920 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BZ167_08925 ENOG4105VPB 50S ribosomal protein L30 BZ167_08930 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BZ167_08935 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BZ167_08940 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BZ167_08945 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BZ167_08955 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BZ167_08970 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BZ167_08975 ENOG41082SA 50s ribosomal protein l29 BZ167_08980 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BZ167_08985 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BZ167_08990 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BZ167_08995 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BZ167_09000 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BZ167_09005 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BZ167_09010 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BZ167_09015 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BZ167_09020 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BZ167_09025 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BZ167_09030 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BZ167_09035 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BZ167_09040 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BZ167_09045 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BZ167_09050 ENOG4105XPM ribosomal protein BZ167_09055 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BZ167_09060 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BZ167_09065 ENOG4107Y49 methyltransferase BZ167_09070 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BZ167_09075 ENOG4108VZM 50s ribosomal protein L10 BZ167_09085 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BZ167_09090 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BZ167_09110 ENOG4105M0M Tetracycline resistance protein BZ167_09115 ENOG4105C2N RNA methyltransferase TrmH family group 3 BZ167_09120 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BZ167_09130 ENOG4105D7W serine acetyltransferase BZ167_09135 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BZ167_09140 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BZ167_09145 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BZ167_09150 ENOG4105CTP PilT protein domain protein BZ167_09155 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BZ167_09160 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BZ167_09170 ENOG41066A3 ATP guanido phosphotransferase BZ167_09175 ENOG4108Z0C Uvrb UvrC protein BZ167_09265 ENOG4105CRK lysyL-tRNA synthetase BZ167_09270 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BZ167_09280 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BZ167_09285 ENOG4105KRF dihydroneopterin aldolase BZ167_09290 ENOG4105EEI dihydropteroate synthase BZ167_09295 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BZ167_09300 ENOG4105DDQ anthranilate synthase BZ167_09305 ENOG4105CRQ synthase (Component I) BZ167_09310 ENOG4105C6T cysteine synthase BZ167_09315 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BZ167_09320 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BZ167_09325 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BZ167_09330 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BZ167_09335 ENOG4108UGV hypoxanthine phosphoribosyltransferase BZ167_09340 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BZ167_09370 ENOG41060GV RNA binding s1 domain protein BZ167_09385 ENOG4105VYY sporulation protein yabp BZ167_09390 ENOG41082I2 s4 domain protein BZ167_09395 ENOG4108IY2 MazG family BZ167_09405 ENOG4108M14 stage v sporulation protein t BZ167_09410 ENOG4108JA2 transcriptioN-repair coupling factor BZ167_09425 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BZ167_09430 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BZ167_09435 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BZ167_09440 ENOG4105K4W Could be involved in septation (By similarity) BZ167_09445 ENOG4105KME endoribonuclease L-psp BZ167_09450 ENOG4105DFT pur operon repressor BZ167_09455 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BZ167_09460 ENOG4105XEW small acid-soluble spore protein BZ167_09465 ENOG4105W42 Veg protein BZ167_09470 ENOG4105XFA sporulation peptidase YabG BZ167_09475 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BZ167_09485 ENOG41069ER domain protein BZ167_09490 ENOG4105F8V Hydrolase, tatD family BZ167_09495 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BZ167_09500 ENOG4105KRN Transcriptional regulator, abrb family BZ167_09505 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BZ167_09510 ENOG4105VC4 domain protein BZ167_09515 ENOG41060K3 Methyltransferase BZ167_09525 ENOG4105MA4 psp1 domain protein BZ167_09530 ENOG4105FA2 dna polymerase iii BZ167_09535 ENOG4105XVJ Protein of unknown function (DUF327) BZ167_09540 ENOG4105X0R protein from nitrogen regulatory protein P-II BZ167_09545 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BZ167_09550 ENOG4105CXN decarboxylase BZ167_09555 ENOG4105CDW Resistance protein BZ167_09595 ENOG41067KS pro-sigma K processing BZ167_09605 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BZ167_09610 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BZ167_09615 ENOG4105C6E dna polymerase iii BZ167_09625 ENOG4108Z6B deaminase BZ167_09630 ENOG4105GTG Isochorismatase BZ167_09635 ENOG4105VRS hydrolase family 18 BZ167_09645 ENOG4105ZMH deoxynucleoside kinase BZ167_09655 ENOG4105BZW Glycerate kinase BZ167_09660 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BZ167_09665 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BZ167_09670 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BZ167_09680 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BZ167_09715 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BZ167_09720 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BZ167_09730 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BZ167_09735 ENOG410848D S4 domain protein YaaA BZ167_09740 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BZ167_09745 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BZ167_09760 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BZ167_09775 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BZ167_09780 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BZ167_09795 ENOG4107QJE Chromosome Partitioning Protein BZ167_09800 ENOG4105FA0 parb-like partition protein BZ167_09805 ENOG4108ZDA Sporulation protein YyaC BZ167_09820 ENOG4105VDK protein, conserved in bacteria BZ167_09825 ENOG4108J2R molybdopterin oxidoreductase BZ167_09830 ENOG4105C3G gtp-binding protein BZ167_09835 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BZ167_09840 ENOG4108UUM single-stranded DNA-binding protein BZ167_09845 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BZ167_09855 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BZ167_09860 ENOG4105CGK Exodeoxyribonuclease III BZ167_09870 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BZ167_09880 ENOG4107FCW Abortive infection protein BZ167_09885 ENOG4105C7Z Conserved Protein BZ167_09890 ENOG4107Y9U Membrane BZ167_09900 ENOG4105DTD Dehydrogenase BZ167_09905 ENOG4105CMU LysR family (Transcriptional regulator BZ167_09910 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BZ167_09920 ENOG41082BV acetyltransferase BZ167_09925 ENOG4108U05 Transcriptional regulator BZ167_09935 ENOG4105FS7 Transcriptional regulator BZ167_09940 ENOG4108TVJ Nitroreductase BZ167_09950 ENOG4108VP3 Lysine exporter protein (LysE YggA) BZ167_09955 ENOG4107V2S Transcriptional regulator BZ167_09970 ENOG4107XBN GntR Family Transcriptional Regulator BZ167_09975 ENOG4108HKT sucrose-6-phosphate hydrolase BZ167_09980 ENOG4105EDQ levansucrase EC 2.4.1.10 BZ167_09985 ENOG4108UZ3 Transporter BZ167_09990 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BZ167_09995 ENOG4105KVH Transcriptional regulator BZ167_10005 ENOG4108XMW Membrane BZ167_10010 ENOG4105BZR domain protein BZ167_10030 ENOG4105CPK Glycosyl transferase (Group 1 BZ167_10035 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BZ167_10045 ENOG4107QPH glycogen) synthase BZ167_10050 ENOG4105EDW glycosyl transferase, family 39 BZ167_10075 ENOG4105CDU Replicative dna helicase BZ167_10080 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BZ167_10085 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BZ167_10115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZ167_10120 ENOG4105BZU Histidine kinase BZ167_10135 ENOG4105Q2H domain protein BZ167_10140 ENOG4105C0H protease BZ167_10150 ENOG41062D9 Histidine kinase BZ167_10155 ENOG4105D06 uba thif-type nad fad binding protein BZ167_10170 ENOG4105C5H ABC transporter BZ167_10180 ENOG4108JUB Transcriptional regulator BZ167_10185 ENOG41082BM Transcriptional regulator, arsr family BZ167_10195 ENOG4105C8Y Acetylornithine aminotransferase BZ167_10200 ENOG4108IQI permease BZ167_10205 ENOG41066UZ arginase EC 3.5.3.1 BZ167_10215 ENOG4105WQG acetyltransferase BZ167_10220 ENOG4105CPC Aldo Keto reductase BZ167_10225 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BZ167_10250 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BZ167_10275 ENOG4105XRQ Xanthine dehydrogenase accessory factor BZ167_10295 ENOG4108XHQ (2Fe-2S)-binding domain protein BZ167_10305 ENOG4105DQ6 Transposase BZ167_10310 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BZ167_10315 ENOG4105C85 amino acid BZ167_10320 ENOG4107R3N Filamentation induced by cAMP protein fic BZ167_10325 ENOG4108JU3 Alkyl hydroperoxide reductase BZ167_10330 ENOG4105D3R alkyl hydroperoxide reductase BZ167_10340 ENOG41085PJ rdd domain containing protein BZ167_10345 ENOG4105F27 Major Facilitator BZ167_10350 ENOG4105WAB arsR family transcriptional regulator BZ167_10360 ENOG4108ITS PQQ enzyme repeat BZ167_10365 ENOG4105C26 Dehydrogenase BZ167_10370 ENOG4105ST3 Transcriptional regulator BZ167_10380 ENOG4105ECK Fatty Acid Desaturase BZ167_10385 ENOG4108ZGX Histidine kinase BZ167_10390 ENOG4108S01 response regulator BZ167_10395 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BZ167_10405 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BZ167_10410 ENOG4107QNK )-transporter BZ167_10415 ENOG4105CPC Aldo Keto reductase BZ167_10425 ENOG4105C26 Dehydrogenase BZ167_10435 ENOG4105EDK PfkB domain protein BZ167_10445 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BZ167_10455 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BZ167_10460 ENOG4105F0H myo-inositol catabolism protein BZ167_10465 ENOG4105WZ4 isomerase BZ167_10490 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZ167_10525 ENOG4108V5C ABC transporter BZ167_10555 ENOG410667J hydrolase BZ167_10560 ENOG4107RHR regulatoR BZ167_10565 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BZ167_10570 ENOG4105D9N nucleoside BZ167_10575 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BZ167_10585 ENOG4107W25 arginase agmatinase formiminoglutamase BZ167_10590 ENOG4105CI2 imidazolone-5-propionate hydrolase BZ167_10595 ENOG4105CGP Urocanate hydratase BZ167_10600 ENOG4105C84 Histidine ammonia-lyase BZ167_10610 ENOG4106Z5D Glycoside Hydrolase Family 43 BZ167_10615 ENOG4105M6F mutator MutT protein BZ167_10630 ENOG4105CS2 ec 3.2.1.21 BZ167_10635 ENOG4107YZX Universal stress protein BZ167_10645 ENOG4108NR7 pectate lyase BZ167_10720 ENOG4105C1J atp-dependent rna helicase BZ167_10725 ENOG4105DEU major facilitator superfamily BZ167_10730 ENOG4105CID antiterminator BZ167_10740 ENOG4105D4T Citrate transporter BZ167_10745 ENOG4105CH6 catalase BZ167_10770 ENOG4105DHI Methyltransferase BZ167_10785 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BZ167_10790 ENOG4105CMR udp-glucose 4-epimerase BZ167_10800 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BZ167_10815 ENOG4107BJW polysaccharide deacetylase BZ167_10820 ENOG4105D2K citrate carrier protein BZ167_10825 ENOG4105C4M (Ubiquinol oxidase) subunit I BZ167_10830 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BZ167_10835 ENOG4108JJ9 ABC, transporter BZ167_10840 ENOG4108JJ8 (ABC) transporter BZ167_10845 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BZ167_10850 ENOG4105ETS cytosine purines uracil thiamine allantoin BZ167_10855 ENOG4107QHE Choloylglycine hydrolase BZ167_10860 ENOG4105CH6 catalase BZ167_10870 ENOG4105DG6 mannose-6-phosphate isomerase BZ167_10875 ENOG4105EVU fructokinase BZ167_10880 ENOG4105CS2 ec 3.2.1.21 BZ167_10885 ENOG4105CK1 PTS System BZ167_10890 ENOG4105VCP PTS System BZ167_10895 ENOG4105VZJ PTS System BZ167_10900 ENOG4107R5R arsenical pump membrane protein BZ167_10905 ENOG41082YX Transcriptional regulator, arsr family BZ167_10910 ENOG4108V5C ABC transporter BZ167_10915 ENOG4105EHG Permease protein BZ167_10920 ENOG4105DQ5 transport system permease protein BZ167_10935 ENOG4105EMD TRANSCRIPTIONal BZ167_10940 ENOG4105VZJ PTS System BZ167_10945 ENOG4105CK1 PTS System BZ167_10950 ENOG4105VCP PTS System BZ167_10955 ENOG4105F8D glycoside hydrolase family 4 BZ167_10960 ENOG4105CM2 brancheD-chain amino acid aminotransferase BZ167_10965 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BZ167_10970 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) BZ167_10975 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BZ167_10980 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BZ167_10995 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BZ167_11010 ENOG4105X1N Glycosyl transferase family 8 BZ167_11015 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BZ167_11020 ENOG4105CK1 PTS System BZ167_11030 ENOG4105DR4 Methyltransferase BZ167_11040 ENOG4107TXC Transcriptional regulator BZ167_11050 ENOG41067MG lrgb family BZ167_11055 ENOG4105VAW lrga family BZ167_11060 ENOG4105CMU LysR family (Transcriptional regulator BZ167_11065 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BZ167_11070 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BZ167_11075 ENOG410650H (LipO)protein BZ167_11080 ENOG4105DBE peroxidase BZ167_11085 ENOG4107ZXU DSBA oxidoreductase BZ167_11110 ENOG4105WH5 Teichoic acid glycosylation protein BZ167_11115 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BZ167_11125 ENOG4107BMA Transglycosylase associated protein BZ167_11130 ENOG4105E2S oxidase) subunit II BZ167_11135 ENOG4105BZ9 Cytochrome C oxidase, subunit I BZ167_11155 ENOG4105I4A GCN5-related N-acetyltransferase BZ167_11165 ENOG4108DBC nitroreductase BZ167_11170 ENOG4105DEN Luciferase family BZ167_11175 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BZ167_11190 ENOG4105C5Y PTS System BZ167_11205 ENOG4105DWF phosphomethylpyrimidine kinase BZ167_11225 ENOG4108RJ9 Glycosyl transferase, family 2 BZ167_11230 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BZ167_11265 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BZ167_11270 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BZ167_11280 ENOG4107TY6 Acylneuraminate cytidylyltransferase BZ167_11285 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BZ167_11290 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BZ167_11295 ENOG4105C1B dTDP-glucose 4-6-dehydratase BZ167_11300 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BZ167_11305 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BZ167_11315 ENOG4105D82 Glutamate dehydrogenase BZ167_11320 ENOG4105C26 Dehydrogenase BZ167_11335 ENOG4105C2C drug resistance transporter, Bcr CflA BZ167_11340 ENOG4105FCW Major Facilitator superfamily BZ167_11370 ENOG4105CHM Aminotransferase BZ167_11380 ENOG4107JTW chlorite dismutase BZ167_11385 ENOG4108IJ2 phosphate acetyltransferase BZ167_11390 ENOG4105HMI Membrane BZ167_11395 ENOG4105DUM transcriptional regulator, lysR family BZ167_11400 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BZ167_11425 ENOG4108TU7 Inherit from COG: (ABC) transporter BZ167_11430 ENOG4105CJ1 ABC, transporter BZ167_11440 ENOG4105K7K Transcriptional regulator BZ167_11445 ENOG4108VCI transcription factor, rsfa family BZ167_11455 ENOG4105DCI Phosphohydrolase BZ167_11465 ENOG4105CUB amino acid BZ167_11475 ENOG41067TZ transcriptional regulator, MarR family BZ167_11480 ENOG41069HH 4-oxalocrotonate tautomerase BZ167_11485 ENOG4108Z4T Peptidase M50 BZ167_11490 ENOG4108XFG YwhD family BZ167_11500 ENOG4105BZ4 penicillin-binding protein BZ167_11505 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BZ167_11510 ENOG4105CYW agmatinase BZ167_11555 ENOG4107JM4 Tetratricopeptide repeat BZ167_11580 ENOG410684U Domain of unknown function (DUF1934) BZ167_11585 ENOG4105C75 arginyL-tRNA synthetase BZ167_11595 ENOG4107V6Q Cyclic nucleotide-binding domain BZ167_11615 ENOG4108IUE nitrate reductase beta subunit BZ167_11620 ENOG4105R3A Nitrate reductase BZ167_11635 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BZ167_11640 ENOG4105BZ1 (ABC) transporter BZ167_11650 ENOG4105E5J UV damage endonuclease BZ167_11660 ENOG4105DF6 Fe-S oxidoreductase BZ167_11670 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BZ167_11680 ENOG410812K response regulator receiver protein BZ167_11685 ENOG4105D2N Aldolase BZ167_11700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BZ167_11705 ENOG4105CBT Fructose-1,6-bisphosphatase BZ167_11710 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BZ167_11715 ENOG41082DI 50s ribosomal protein l31 BZ167_11720 ENOG4107104 thymidine kinase BZ167_11725 ENOG4105C6K Malic enzyme BZ167_11730 ENOG4107TT2 Auxin Efflux Carrier BZ167_11740 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BZ167_11745 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BZ167_11750 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BZ167_11765 ENOG4108ZXQ stage ii sporulation protein r BZ167_11775 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BZ167_11780 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BZ167_11785 ENOG4107WAU Protein tyrosine phosphatase BZ167_11790 ENOG4108YZG isomerase BZ167_11795 ENOG4108UIC UPF0340 protein BZ167_11800 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BZ167_11805 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BZ167_11815 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BZ167_11830 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BZ167_11835 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BZ167_11840 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BZ167_11845 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BZ167_11850 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BZ167_11860 ENOG4106778 Protein of unknown function (DUF1146) BZ167_11870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BZ167_11885 ENOG4108TF4 von Willebrand factor, type A BZ167_11890 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BZ167_11895 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BZ167_11915 ENOG4108YZ9 Urea amidohydrolase subunit gamma BZ167_11920 ENOG4105KI2 Urea amidohydrolase subunit beta BZ167_11925 ENOG4105CQM Urea amidohydrolase subunit alpha BZ167_11930 ENOG4108Z40 Transcriptional regulator BZ167_11940 ENOG4107T94 Endo-14-beta-xylanase BZ167_11950 ENOG4106BRK BZ167_11955 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BZ167_11970 ENOG4107TCE N-acetyltransferase BZ167_11975 ENOG4105FRN stage II sporulation protein BZ167_11985 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BZ167_11990 ENOG4105CNI cell division protein FtsW BZ167_12000 ENOG4105BZU Histidine kinase BZ167_12005 ENOG4105D3W isochorismatase BZ167_12010 ENOG41080V3 Major Facilitator superfamily BZ167_12015 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BZ167_12020 ENOG4105CZM Major Facilitator BZ167_12025 ENOG4107MII Sugar-specific transcriptional regulator TrmB BZ167_12030 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BZ167_12035 ENOG4105DFF Rod shape-determining protein mreb BZ167_12045 ENOG4105CGA flagellar basal-body rod protein FlgG BZ167_12055 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BZ167_12060 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BZ167_12075 ENOG4105Z8H single-stranded DNA-binding protein BZ167_12080 ENOG4105E98 transcriptional regulator DeoR family BZ167_12085 ENOG410667J hydrolase BZ167_12090 ENOG4105C0D helicase BZ167_12095 ENOG4105KBK Zinc finger, swim domain protein BZ167_12105 ENOG4105HTX biosynthesis protein BZ167_12110 ENOG4107YJ4 chain length determinant protein BZ167_12115 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BZ167_12120 ENOG4105C6Y Udp-glucose 6-dehydrogenase BZ167_12125 ENOG4108XI2 Domain of unknown function (DUF1963) BZ167_12160 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BZ167_12165 ENOG4105FGV Chromate BZ167_12170 ENOG4105CAH Chromate BZ167_12180 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BZ167_12190 ENOG4107XC4 flavin reductase domain protein, FMN-binding BZ167_12205 ENOG4106UIA BZ167_12220 ENOG4107RSM transcriptional regulator BZ167_12230 ENOG4107FQX Alpha-acetolactate decarboxylase BZ167_12235 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BZ167_12245 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BZ167_12250 ENOG4105CNN ABC, transporter BZ167_12255 ENOG4105C2J ABC transporter BZ167_12260 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BZ167_12265 ENOG4108RVA ribokinase BZ167_12270 ENOG4105ETE Transcriptional regulator (LacI family BZ167_12285 ENOG4105E1K spore germination protein BZ167_12295 ENOG4105N98 Capsule biosynthesis protein capB BZ167_12305 ENOG4105PNM synthesis protein BZ167_12310 ENOG4105K4H Nlp p60 protein BZ167_12315 ENOG4106UBQ BZ167_12320 ENOG4105J7I hydrolase BZ167_12325 ENOG4108KGH TRANSCRIPTIONal BZ167_12330 ENOG4105C54 Major Facilitator superfamily BZ167_12335 ENOG4107R8N Glycosyl transferase, family 2 BZ167_12340 ENOG4108NHD germination protein BZ167_12355 ENOG4105DG6 mannose-6-phosphate isomerase BZ167_12365 ENOG4107RZX Teichoic acid biosynthesis protein BZ167_12375 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BZ167_12380 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BZ167_12385 ENOG4107SJB teichoic acid biosynthesis BZ167_12395 ENOG4105EY8 ABC transporter BZ167_12400 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BZ167_12405 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BZ167_12410 ENOG4108KGH TRANSCRIPTIONal BZ167_12420 ENOG4105JFG SpoIID LytB domain protein BZ167_12425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BZ167_12430 ENOG4105D3Q Sugar transferase BZ167_12435 ENOG4105PSV Polysaccharide Biosynthesis Protein BZ167_12440 ENOG4107RA4 Glycosyl transferase (Group 1 BZ167_12445 ENOG4105C6Y Udp-glucose 6-dehydrogenase BZ167_12450 ENOG4105QZI O-Antigen Polymerase BZ167_12465 ENOG4107EF8 Glycosyl transferase (Group 1 BZ167_12470 ENOG4105ESV Glycosyl transferase, family 4 BZ167_12475 ENOG4108KGH TRANSCRIPTIONal BZ167_12480 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BZ167_12485 ENOG4105BZU Histidine kinase BZ167_12490 ENOG4105WH1 Two component transcriptional regulator luxr family BZ167_12510 ENOG41081UC Inherit from COG: Competence protein BZ167_12515 ENOG4105RU3 BZ167_12530 ENOG4105E1Q flagellar hook-associated protein BZ167_12535 ENOG4105DTJ flagellar hook-associated protein BZ167_12545 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BZ167_12550 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BZ167_12555 ENOG4105I03 Flagellin BZ167_12560 ENOG4107RT6 flagellar hook-associated BZ167_12565 ENOG4105MQ3 flagellar protein FliS BZ167_12580 ENOG4105MS2 ribosomal subunit Interface protein BZ167_12585 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BZ167_12590 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BZ167_12595 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BZ167_12610 ENOG4105CAK Cell division ATP-binding protein ftsE BZ167_12615 ENOG4105CRP Part of the ABC transporter FtsEX involved in BZ167_12620 ENOG4108M26 parallel beta-helix repeat protein BZ167_12625 ENOG4105CN1 protease BZ167_12650 ENOG4105MKU Transcriptional regulator BZ167_12665 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BZ167_12670 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BZ167_12685 ENOG4108PY7 BZ167_12690 ENOG41067S9 phage shock protein C, PspC BZ167_12695 ENOG41086DT Membrane protein of unknown function BZ167_12700 ENOG41088CQ domain protein BZ167_12705 ENOG4105J7D transcriptional regulator BZ167_12710 ENOG4105FDP GntR family transcriptional regulator BZ167_12715 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BZ167_12720 ENOG4105CE4 GlcNAc 6-P deacetylase BZ167_12725 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BZ167_12735 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BZ167_12740 ENOG4108S4C acetyltransferase BZ167_12750 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BZ167_12755 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BZ167_12760 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BZ167_12765 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BZ167_12770 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BZ167_12775 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BZ167_12780 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BZ167_12785 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BZ167_12790 ENOG4105BZ1 (ABC) transporter BZ167_12795 ENOG4105GIG BZ167_12800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZ167_12805 ENOG4105BZU Histidine kinase BZ167_12820 ENOG4105C3M thioredoxin reductase BZ167_12825 ENOG4108Z4K mutator MutT protein BZ167_12830 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BZ167_12835 ENOG4105CHW UPF0052 protein BZ167_12840 ENOG4105CIE May be required for sporulation (By similarity) BZ167_12845 ENOG4105KRI phosphocarrier protein (HPr BZ167_12850 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BZ167_12855 ENOG4105DQ6 Transposase BZ167_12865 ENOG4105GGE ribonuclease BZ167_12870 ENOG4105C5I Dehydrogenase BZ167_12880 ENOG4108V2W Carbonate dehydratase BZ167_12885 ENOG4105CHH sulfate transporter BZ167_12890 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BZ167_12895 ENOG4108URH decarboxylase BZ167_12905 ENOG4105C7F AcnD-accessory protein PrpF BZ167_12910 ENOG4108KAM Transcriptional regulator BZ167_12915 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BZ167_12920 ENOG4105ETE Transcriptional regulator (LacI family BZ167_12925 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BZ167_12930 ENOG4108HKT sucrose-6-phosphate hydrolase BZ167_12985 ENOG4105NI3 Protein of unknown function (DUF3237) BZ167_12990 ENOG4105PY6 Phenolic acid decarboxylase BZ167_12995 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BZ167_13005 ENOG4105NAE bifunctional deaminase-reductase domain protein BZ167_13010 ENOG4105EBR Carboxylesterase BZ167_13020 ENOG4105HTX biosynthesis protein BZ167_13025 ENOG4108QV3 biosynthesis protein BZ167_13035 ENOG4108PQP glycosyl transferase group 1 BZ167_13040 ENOG4105K64 Glycosyl transferase, family 2 BZ167_13045 ENOG4108KMV Glycosyl transferase (Group 1 BZ167_13050 ENOG41068W6 Capsular polysaccharide biosynthesis protein BZ167_13055 ENOG4107QRS glycosyltransferase group 2 family protein BZ167_13065 ENOG4105K64 Glycosyl transferase, family 2 BZ167_13075 ENOG4105D3Q Sugar transferase BZ167_13080 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BZ167_13085 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BZ167_13090 ENOG4108ZPC Polysaccharide pyruvyl transferase BZ167_13100 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZ167_13105 ENOG4105DAA L-lactate BZ167_13110 ENOG4105JXH GntR family transcriptional regulator BZ167_13115 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BZ167_13120 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BZ167_13125 ENOG4107QR9 Iron-sulfur cluster binding protein BZ167_13135 ENOG4105C6Z Gluconate BZ167_13140 ENOG4105CMG Carbohydrate kinase BZ167_13145 ENOG4106KNT transcriptional regulator BZ167_13150 ENOG410667J hydrolase BZ167_13175 ENOG4107RT3 EamA-like transporter family BZ167_13180 ENOG4105GZI Transcriptional regulator BZ167_13185 ENOG4105DEN Luciferase family BZ167_13195 ENOG4105CMD Transcriptional regulator, GntR family BZ167_13210 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BZ167_13220 ENOG4105BZA Phosphoglycerate kinase BZ167_13225 ENOG4105CP7 Triose-phosphate isomerase BZ167_13230 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BZ167_13235 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BZ167_13240 ENOG4105IIU Aminopeptidase BZ167_13245 ENOG4107QQG Dehydrogenase BZ167_13250 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BZ167_13255 ENOG4108IAJ Nad-dependent epimerase dehydratase BZ167_13260 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BZ167_13275 ENOG4105FJR Lmbe family BZ167_13290 ENOG4108W0I acetyltransferase BZ167_13295 ENOG4105T65 Membrane-associated protein BZ167_13310 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BZ167_13315 ENOG4107HG4 Transcriptional regulator BZ167_13320 ENOG4108IJ8 ABC transporter BZ167_13325 ENOG4105E90 ABC transporter BZ167_13330 ENOG4108HQR Glycine betaine BZ167_13335 ENOG4105R40 Glycine betaine carnitine choline BZ167_13340 ENOG4107HG4 Transcriptional regulator BZ167_13345 ENOG4108IJ8 ABC transporter BZ167_13350 ENOG4105E90 ABC transporter BZ167_13355 ENOG4108HQR Glycine betaine BZ167_13360 ENOG4105R40 Glycine betaine carnitine choline BZ167_13365 ENOG4105DA5 (ABC) transporter BZ167_13390 ENOG4105KVH Transcriptional regulator BZ167_13410 ENOG4105XZU Preprotein translocase, subunit SecG BZ167_13420 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BZ167_13425 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BZ167_13435 ENOG41067XF inhibitor BZ167_13440 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BZ167_13445 ENOG4108KSA LysR family transcriptional regulator BZ167_13450 ENOG4108XSB acetyltransferase, (GNAT) family BZ167_13475 ENOG4105CDA abc transporter atp-binding protein BZ167_13480 ENOG4105DEN Luciferase family BZ167_13520 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BZ167_13525 ENOG4105D9R oxidoreductase BZ167_13530 ENOG4105VPX protein, conserved in bacteria BZ167_13535 ENOG410681U heavy metal transport detoxification protein BZ167_13540 ENOG4105C59 p-type ATPase BZ167_13545 ENOG4105C59 p-type ATPase BZ167_13550 ENOG4107ZQN disulfide bond BZ167_13565 ENOG4105EN6 Membrane BZ167_13570 ENOG4105EEM helicase BZ167_13575 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BZ167_13580 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BZ167_13590 ENOG4105EEQ Na H antiporter BZ167_13605 ENOG4108KYE ABC-2 type transporter BZ167_13615 ENOG4105CJ1 ABC, transporter BZ167_13620 ENOG4105BZU Histidine kinase BZ167_13625 ENOG4105WH1 Two component transcriptional regulator luxr family BZ167_13630 ENOG4105E0C molybdate abc transporter BZ167_13635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BZ167_13640 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BZ167_13645 ENOG4107QZ2 Sulfatase BZ167_13650 ENOG4107K5X Membrane-bound metal-dependent hydrolase BZ167_13665 ENOG4105D5Q Arginine ornithine antiporter BZ167_13670 ENOG4105JQZ Methyltransferase BZ167_13680 ENOG4105DQ5 transport system permease protein BZ167_13685 ENOG4105EHG Permease protein BZ167_13690 ENOG4105E0A ABC, transporter BZ167_13700 ENOG4105F0F Oxalate decarboxylase BZ167_13710 ENOG4106DF4 Sigma-70, region 4 BZ167_13720 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZ167_13730 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BZ167_13735 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BZ167_13740 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BZ167_13745 ENOG4105EHG Permease protein BZ167_13750 ENOG4105E0A ABC, transporter BZ167_13755 ENOG4108WBT adenosyltransferase BZ167_13770 ENOG41087YS Phage shock protein A BZ167_13785 ENOG4105ENE Histidine kinase BZ167_13790 ENOG4105WH1 Two component transcriptional regulator luxr family BZ167_13815 ENOG4105C9Q fumarate hydratase class II BZ167_13820 ENOG41067SE Tetr family transcriptional regulator BZ167_13825 ENOG4105F3H Histidine kinase BZ167_13840 ENOG4105C0H protease BZ167_13845 ENOG4105HUF DNA protection during starvation protein BZ167_13850 ENOG4105E1F short-chain dehydrogenase reductase BZ167_13865 ENOG4105E0A ABC, transporter BZ167_13885 ENOG4105C5Q Transcriptional regulator BZ167_13890 ENOG4105EGI Transcriptional regulator BZ167_13900 ENOG4105MDS 4-oxalocrotonate tautomerase BZ167_13905 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZ167_13910 ENOG41067TZ transcriptional regulator, MarR family BZ167_13925 ENOG4105C0R drug resistance transporter emrb qaca subfamily BZ167_13945 ENOG4105CHU acetyl-coa acetyltransferase BZ167_13950 ENOG4105C1G acyl-Coa dehydrogenase BZ167_13955 ENOG41080E8 Transcriptional regulator, Spx MgsR family BZ167_13960 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BZ167_13985 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BZ167_13990 ENOG4108UMI ABC transporter, permease BZ167_13995 ENOG4105D01 (LipO)protein BZ167_14005 ENOG4105C3K feS assembly ATPase SufC BZ167_14010 ENOG4105JRK feS assembly protein SufD BZ167_14015 ENOG4105C9B Cysteine desulfurase BZ167_14020 ENOG4108UNV SUF system FeS assembly protein, NifU family BZ167_14025 ENOG4105DIW FeS assembly protein SUFB BZ167_14030 ENOG41083Q9 chitosanase BZ167_14040 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BZ167_14045 ENOG4107VFR oxidoreductase BZ167_14050 ENOG4105PKS Excinuclease abc c subunit domain protein BZ167_14070 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BZ167_14075 ENOG4105XN3 extracellular solute-binding protein family 1 BZ167_14080 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BZ167_14085 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BZ167_14090 ENOG4108KPW sugar kinase BZ167_14095 ENOG4105FDP GntR family transcriptional regulator BZ167_14100 ENOG4108IJ9 (ABC) transporter BZ167_14105 ENOG4108K8S endonuclease I BZ167_14115 ENOG4105C5R Aminotransferase BZ167_14140 ENOG4105G9B Transcriptional regulator BZ167_14145 ENOG4105CD3 dihydroorotase BZ167_14155 ENOG4105I3N Conserved Protein BZ167_14165 ENOG4107R8B 5'-nucleotidase BZ167_14170 ENOG4108YTE sporulation protein YunB BZ167_14175 ENOG4105FAA peptidase M23 BZ167_14180 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BZ167_14190 ENOG4105MMD transcriptional regulator BZ167_14200 ENOG4105D4U had-superfamily hydrolase, subfamily iia BZ167_14205 ENOG4108W5N phosphatidylglycerophosphatase a BZ167_14215 ENOG4105D6E homoserine dehydrogenase BZ167_14220 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BZ167_14225 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BZ167_14230 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BZ167_14235 ENOG41083MR nifu domain-containing protein BZ167_14250 ENOG4105ZKE UPF0349 protein BZ167_14260 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BZ167_14265 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BZ167_14270 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BZ167_14275 ENOG4105D9U N-acetyltransferase BZ167_14295 ENOG4105CJ1 ABC, transporter BZ167_14310 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BZ167_14325 ENOG4105CEP NADH dehydrogenase BZ167_14335 ENOG41069ER domain protein BZ167_14345 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BZ167_14365 ENOG4105NIV Esterase BZ167_14370 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BZ167_14375 ENOG4105E4F Isochorismate synthase BZ167_14380 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BZ167_14385 ENOG4105WQI isochorismatase BZ167_14390 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_14395 ENOG4105WQT MbtH domain protein BZ167_14405 ENOG4105DCF alanine dehydrogenase BZ167_14410 ENOG4108K8K Transcriptional regulator BZ167_14445 ENOG410904N short-chain dehydrogenase reductase BZ167_14460 ENOG4105C02 permease BZ167_14485 ENOG4105DAP Nicotinate phosphoribosyltransferase BZ167_14490 ENOG4105D58 Diguanylate phosphodiesterase BZ167_14520 ENOG4105BZU Histidine kinase BZ167_14530 ENOG4105KA0 thioesterase Superfamily protein BZ167_14535 ENOG4105KJM monovalent cation h antiporter subunit g BZ167_14545 ENOG4105SC1 monovalent cation H antiporter subunit E BZ167_14550 ENOG4108JPZ Monovalent cation H antiporter subunit D BZ167_14555 ENOG4108ZE9 Monovalent cation H antiporter subunit C BZ167_14560 ENOG4105HC0 Na H antiporter BZ167_14565 ENOG4105D65 subunit l BZ167_14580 ENOG4105UIB (ABC) transporter BZ167_14585 ENOG4108JQ9 ABC transporter BZ167_14590 ENOG4105DIH basic membrane BZ167_14595 ENOG4108MRH transcriptional regulatory protein BZ167_14610 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BZ167_14615 ENOG4105BZ4 penicillin-binding protein BZ167_14630 ENOG4105Y38 Kinase-associated protein B BZ167_14635 ENOG4108HGU Histidine kinase BZ167_14640 ENOG4105C87 Aminotransferase class I and II BZ167_14650 ENOG4108MUZ hydrolase BZ167_14655 ENOG4108ZB6 transcriptional regulator AsnC family BZ167_14660 ENOG4105CHM Aminotransferase BZ167_14675 ENOG4105DQ6 Transposase BZ167_14680 ENOG4105WG9 Conserved Protein BZ167_14685 ENOG4107QW4 alcohol dehydrogenase BZ167_14695 ENOG4105CHJ isochorismatase hydrolase BZ167_14710 ENOG4107QYV phosphohexose isomerase BZ167_14725 ENOG4107PBV potassium channel BZ167_14730 ENOG4107PBV potassium channel BZ167_14745 ENOG4105C37 (CBS) domain BZ167_14755 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BZ167_14760 ENOG4105EA8 2-Nitropropane dioxygenase BZ167_14775 ENOG4105C8Q Methyl-accepting chemotaxis BZ167_14780 ENOG4105C8Q Methyl-accepting chemotaxis BZ167_14785 ENOG4105C8Q Methyl-accepting chemotaxis BZ167_14790 ENOG4105C8Q Methyl-accepting chemotaxis BZ167_14795 ENOG4108Z0Z intracellular protease Pfpi family BZ167_14800 ENOG4105EE0 oxidoreductase BZ167_14810 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BZ167_14855 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BZ167_14860 ENOG4105DQ6 Transposase BZ167_14870 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BZ167_14885 ENOG4105DQ6 Transposase BZ167_14895 ENOG4105TRT Transcriptional regulator BZ167_14900 ENOG4105C26 Dehydrogenase BZ167_14905 ENOG4108JB8 alcohol dehydrogenase BZ167_14910 ENOG4108VNY MOSC domain protein BZ167_14915 ENOG4106DF1 BZ167_14925 ENOG4105DZ6 Band 7 protein BZ167_14930 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BZ167_15065 ENOG4105E4F Isochorismate synthase BZ167_15070 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BZ167_15075 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BZ167_15080 ENOG4108IPT Naphthoate synthase BZ167_15085 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_15090 ENOG4105DTQ mandelate racemase muconate lactonizing BZ167_15115 ENOG4105NRA 50s ribosomal protein l31 type b BZ167_15120 ENOG4108V2W Carbonate dehydratase BZ167_15125 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BZ167_15130 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BZ167_15145 ENOG4108RMU ferritin dps family protein BZ167_15160 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BZ167_15170 ENOG4105D2X ABC transporter substrate-binding protein BZ167_15185 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BZ167_15190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BZ167_15195 ENOG4105CAQ asparagine synthetase BZ167_15200 ENOG4105C85 amino acid BZ167_15205 ENOG4108Z0R Transferase BZ167_15210 ENOG4105E8V Alpha Beta Hydrolase Fold protein BZ167_15220 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BZ167_15235 ENOG4105N5T Radical SAM Protein BZ167_15255 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BZ167_15260 ENOG4105DVE abc transporter atp-binding protein BZ167_15285 ENOG4107R34 abc transporter permease protein BZ167_15295 ENOG4105EWM Histidine kinase BZ167_15300 ENOG4105C19 ABC transporter BZ167_15320 ENOG410605W Major Facilitator BZ167_15325 ENOG4105BZU Histidine kinase BZ167_15335 ENOG4105C8T Leucyl-tRNA synthetase BZ167_15340 ENOG41085GJ domain protein BZ167_15355 ENOG4105I1K ABC transporter BZ167_15360 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BZ167_15380 ENOG4105C94 Transporter BZ167_15385 ENOG4105CBX hi0933 family BZ167_15400 ENOG4105YW5 deoR family transcriptional regulator BZ167_15415 ENOG4105C7N Xanthine uracil vitamin C permease BZ167_15420 ENOG4107QSE Dipeptidase BZ167_15425 ENOG4105C6T cysteine synthase BZ167_15430 ENOG4107F58 2'-5' rna ligase BZ167_15445 ENOG4108V15 phosphotransferase enzyme family BZ167_15455 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BZ167_15460 ENOG4105C8F Beta-lactamase domain protein BZ167_15465 ENOG4105C6K Malic enzyme BZ167_15480 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BZ167_15495 ENOG4108VDD TRNA binding domain protein BZ167_15505 ENOG4105DFU Cell wall formation (By similarity) BZ167_15525 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BZ167_15530 ENOG4105ETE Transcriptional regulator (LacI family BZ167_15535 ENOG4107R0U MotA TolQ exbB proton channel BZ167_15540 ENOG4105ER2 Ompa motb domain protein BZ167_15545 ENOG4105DGU Histone deacetylase BZ167_15550 ENOG4105W87 Cbs domain BZ167_15555 ENOG4105F1V Acetoin utilization protein BZ167_15570 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BZ167_15580 ENOG4108UMN azlc family BZ167_15585 ENOG4108NGU Transcriptional regulator BZ167_15610 ENOG4108Z0Z intracellular protease Pfpi family BZ167_15620 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BZ167_15680 ENOG4105C26 Dehydrogenase BZ167_15685 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BZ167_15695 ENOG4105BZU Histidine kinase BZ167_15705 ENOG4105U5Y Transcriptional regulator BZ167_15730 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BZ167_15740 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BZ167_15745 ENOG4105EFZ amidohydrolase BZ167_15750 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BZ167_15755 ENOG4105D07 Signal peptide peptidase, SppA BZ167_15760 ENOG4105VK3 rdd domain containing protein BZ167_15770 ENOG4105KBJ sporulation protein ytfj BZ167_15775 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BZ167_15785 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BZ167_15790 ENOG4105EPU Molybdenum cofactor synthesis domain protein BZ167_15795 ENOG4105CDH Citrulline--aspartate ligase BZ167_15800 ENOG4105CH7 arginosuccinase BZ167_15810 ENOG4105E8R UPF0173 metal-dependent hydrolase BZ167_15825 ENOG4105SFS phosphoesterase RecJ domain protein BZ167_15830 ENOG4106EVM BZ167_15840 ENOG4105VV2 BZ167_15845 ENOG4105C0B DNA polymerase III (alpha subunit) BZ167_15850 ENOG4105C6K Malic enzyme BZ167_15855 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BZ167_15860 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BZ167_15865 ENOG4105CTQ phosphohexokinase BZ167_15870 ENOG4105CA9 Pyruvate kinase BZ167_15875 ENOG4105FS0 cytoplasmic membrane protein BZ167_15880 ENOG4108REF Sporulation integral membrane protein ytvi BZ167_15890 ENOG4105G7B Protein of unknown function (DUF2992) BZ167_15895 ENOG4105BZN citrate synthase BZ167_15900 ENOG4108HMX isocitrate dehydrogenase (NADP) BZ167_15910 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZ167_15915 ENOG4105BZU Histidine kinase BZ167_15920 ENOG4105C2M dna polymerase I BZ167_15925 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BZ167_15935 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BZ167_15940 ENOG4105CV8 reductase BZ167_15945 ENOG4105F27 Major Facilitator BZ167_15950 ENOG4105KVH Transcriptional regulator BZ167_15955 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BZ167_15960 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BZ167_15985 ENOG4108TDW sporulation protein YtxC BZ167_15990 ENOG4105C22 threonyL-tRNA synthetase BZ167_15995 ENOG4105U0R haloacid dehalogenase-like hydrolase BZ167_16000 ENOG4108HRK Histidine kinase BZ167_16005 ENOG4105DY9 regulatoR BZ167_16015 ENOG41067MG lrgb family BZ167_16020 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BZ167_16025 ENOG4105VJV 50s ribosomal protein L35 BZ167_16030 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BZ167_16035 ENOG410696E Membrane BZ167_16045 ENOG4105CN9 Peptidase m42 family protein BZ167_16050 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BZ167_16060 ENOG4105EF1 ribulokinase BZ167_16065 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BZ167_16075 ENOG4108MDK Dehydrogenase BZ167_16090 ENOG4105DRS transport system, permease BZ167_16095 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BZ167_16105 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BZ167_16110 ENOG4105CQB FAD linked oxidase domain protein BZ167_16120 ENOG41067MF small acid-soluble spore protein BZ167_16125 ENOG4108RWN rrna methyltransferase BZ167_16130 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BZ167_16135 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BZ167_16140 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BZ167_16155 ENOG4105DCG PHP domain protein BZ167_16160 ENOG4105C98 muts2 protein BZ167_16170 ENOG4108YV3 Protein of unknown function (DUF2711) BZ167_16175 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_16180 ENOG4107Z3H Transcriptional regulator, TetR family BZ167_16185 ENOG41060WC Enoyl-CoA hydratase BZ167_16190 ENOG4105BZJ Electron transfer flavoprotein BZ167_16195 ENOG4105C10 Electron transfer flavoprotein BZ167_16200 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BZ167_16205 ENOG4105K63 Thioredoxin BZ167_16210 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BZ167_16220 ENOG4105CFH Aspartokinase BZ167_16230 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BZ167_16240 ENOG4105E33 succinate dehydrogenase BZ167_16250 ENOG4105PFC Transcriptional regulator BZ167_16255 ENOG41067TZ transcriptional regulator, MarR family BZ167_16260 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BZ167_16265 ENOG4108XJQ germination protein BZ167_16270 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BZ167_16275 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BZ167_16280 ENOG4105M59 Phosphodiesterase, mj0936 family BZ167_16295 ENOG4107SCJ type I restriction enzyme EcoKI subunit R BZ167_16325 ENOG4105C7K acetolactate synthase BZ167_16330 ENOG4108ZP8 Acetolactate synthase small subunit BZ167_16335 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BZ167_16345 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BZ167_16350 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BZ167_16355 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BZ167_16365 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BZ167_16370 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BZ167_16375 ENOG4108IUQ atp-dependent protease BZ167_16380 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BZ167_16385 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BZ167_16395 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BZ167_16405 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BZ167_16415 ENOG4105D52 delta-aminolevulinic acid dehydratase BZ167_16420 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BZ167_16425 ENOG41068KH stage VI sporulation protein D BZ167_16430 ENOG4106AR7 Spore coat protein BZ167_16440 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BZ167_16445 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BZ167_16450 ENOG4106A3R peptidase BZ167_16460 ENOG4108Z03 MAF-like protein BZ167_16465 ENOG4105W5Q DNA repair protein (RadC BZ167_16470 ENOG4105DFF Rod shape-determining protein mreb BZ167_16475 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BZ167_16480 ENOG4105YHC Rod shape-determining protein MreD BZ167_16485 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BZ167_16490 ENOG4107QMS site-determining protein BZ167_16505 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BZ167_16510 ENOG4105X36 (ribosomal) protein BZ167_16515 ENOG4105K46 50S ribosomal protein l27 BZ167_16525 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BZ167_16535 ENOG4105CQC Prephenate dehydratase BZ167_16550 ENOG4108IYU L-aspartate oxidase BZ167_16555 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BZ167_16560 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BZ167_16565 ENOG4106678 morphogenetic protein associated with SpoVID BZ167_16585 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BZ167_16590 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BZ167_16595 ENOG41061AI Protein of unknown function (DUF2905) BZ167_16600 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BZ167_16605 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BZ167_16610 ENOG4105VIE preprotein translocase, subunit YajC BZ167_16615 ENOG4105NAP BZ167_16620 ENOG4108QG2 Membrane BZ167_16625 ENOG4105CKP Polysaccharide Biosynthesis Protein BZ167_16635 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BZ167_16640 ENOG4105NCW Trka-c domain protein BZ167_16645 ENOG41067VP Protein of unknown function (DUF1049) BZ167_16650 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BZ167_16660 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BZ167_16665 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BZ167_16670 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BZ167_16675 ENOG4105CUT histidyl-tRNA synthetase BZ167_16680 ENOG4105C9M aspartyl-trna synthetase BZ167_16690 ENOG4105CUZ uba thif-type nad fad binding protein BZ167_16695 ENOG4105D1H recombination factor protein RarA BZ167_16705 ENOG4105C3J Cysteine desulfurase BZ167_16710 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BZ167_16720 ENOG4105C7H Helicase, RecD TraA family BZ167_16730 ENOG41060CR BZ167_16740 ENOG4105DRP amino acid AbC transporter BZ167_16745 ENOG4105EAD ABC transporter BZ167_16750 ENOG4105CT1 (ABC) transporter BZ167_16755 ENOG4105CDA abc transporter atp-binding protein BZ167_16760 ENOG4105C02 permease BZ167_16765 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BZ167_16770 ENOG4105VBH UPF0297 protein BZ167_16775 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BZ167_16785 ENOG4105HHA aminodeoxychorismate lyase BZ167_16790 ENOG4108VQJ O-methyltransferase BZ167_16795 ENOG4105XYU peptidase (U32 family) BZ167_16800 ENOG4105CFP Peptidase U32 BZ167_16810 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BZ167_16815 ENOG4107XRG penicillin-binding protein BZ167_16845 ENOG4105C28 cystathionine BZ167_16860 ENOG4108JB9 formate dehydrogenase BZ167_16865 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BZ167_16870 ENOG4105TMB Formate nitrite transporter BZ167_16890 ENOG41082JN Transcriptional regulator BZ167_16895 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BZ167_16900 ENOG4105D94 Major Facilitator Superfamily BZ167_16905 ENOG4107RSM transcriptional regulator BZ167_16910 ENOG4108Z66 YbaK ebsC protein BZ167_16925 ENOG4105DM4 PTS System BZ167_16930 ENOG4105DG6 mannose-6-phosphate isomerase BZ167_16940 ENOG4108HCJ Hydrolase BZ167_16945 ENOG4105DQF Hydrolase BZ167_16960 ENOG4108U7W acetyltransferase BZ167_17020 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BZ167_17025 ENOG4108UYN gCN5-related N-acetyltransferase BZ167_17030 ENOG4105DHF Membrane BZ167_17035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BZ167_17040 ENOG4108SWU Histidine kinase BZ167_17065 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZ167_17080 ENOG41080BT SNARE associated Golgi BZ167_17100 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BZ167_17105 ENOG4105CQW ribosome biogenesis GTPase YqeH BZ167_17110 ENOG4105E2X shikimate dehydrogenase BZ167_17115 ENOG410812S Rna-binding protein BZ167_17120 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BZ167_17125 ENOG4108WF2 Metal Dependent Phosphohydrolase BZ167_17135 ENOG4108D32 Methyltransferase BZ167_17145 ENOG4105KQC Competence protein BZ167_17150 ENOG4108UK2 deaminase BZ167_17155 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BZ167_17165 ENOG4105TQK DNA polymerase iii, delta' subunit BZ167_17170 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BZ167_17175 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BZ167_17180 ENOG4108ZRV stage ii sporulation protein p BZ167_17190 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BZ167_17195 ENOG4105CSA Coproporphyrinogen iii oxidase BZ167_17200 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BZ167_17205 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BZ167_17210 ENOG4105CFG Acts as a chaperone (By similarity) BZ167_17215 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BZ167_17220 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BZ167_17225 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BZ167_17230 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BZ167_17235 ENOG4105DQ6 Transposase BZ167_17255 ENOG4105KTH gatB Yqey BZ167_17260 ENOG4105F7J membrane-bound serine protease BZ167_17265 ENOG4105DI5 UPF0365 protein BZ167_17275 ENOG41068P3 sporulation protein YqfC BZ167_17280 ENOG4105EI1 sporulation protein yqfd BZ167_17285 ENOG4105C9A Phoh family BZ167_17290 ENOG4105CTJ Metal Dependent Phosphohydrolase BZ167_17295 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BZ167_17300 ENOG4107YR5 Diacylglycerol kinase BZ167_17305 ENOG4105KG3 cytidine deaminase BZ167_17310 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BZ167_17320 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BZ167_17325 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BZ167_17330 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BZ167_17340 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BZ167_17345 ENOG4108UPT UPF0178 protein BZ167_17350 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BZ167_17355 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZ167_17370 ENOG4105EGD dinuclear metal center protein, YbgI family BZ167_17375 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BZ167_17390 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BZ167_17395 ENOG41069ZM Protein of unknown function (DUF2624) BZ167_17400 ENOG4108JYZ YitT family BZ167_17405 ENOG4105N80 Ferric uptake regulator, Fur family BZ167_17410 ENOG4108U5J '-nucleotidase BZ167_17415 ENOG41063Y9 BZ167_17420 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BZ167_17435 ENOG4105SXS Protein of unknown function (DUF456) BZ167_17440 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BZ167_17450 ENOG4107RF6 penicillin-binding protein BZ167_17455 ENOG4105CVA phosphate BZ167_17460 ENOG4105C8U phosphate abc transporter BZ167_17465 ENOG4105E2Z phosphate ABC transporter (Permease BZ167_17470 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BZ167_17475 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BZ167_17480 ENOG41068DG YceG-like family BZ167_17490 ENOG4105WDJ 50S ribosomal protein L33 BZ167_17495 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BZ167_17535 ENOG4105C5X domain protein BZ167_17560 ENOG4105C37 (CBS) domain BZ167_17620 ENOG4105VFR signal peptidase BZ167_17630 ENOG4108IMY Transcriptional regulator BZ167_17645 ENOG4105C0D helicase BZ167_17650 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BZ167_17660 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BZ167_17665 ENOG4105WZW rhodanese family BZ167_17670 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BZ167_17690 ENOG4105CBJ Metal-dependent enzyme BZ167_17700 ENOG4105DC7 peptidase M24 BZ167_17705 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BZ167_17715 ENOG4105CD2 stage iii sporulation protein aa BZ167_17720 ENOG4105KR5 Stage iii sporulation protein BZ167_17725 ENOG4108CQH stage III sporulation protein AC BZ167_17730 ENOG4105KQ4 Stage iii sporulation protein ad BZ167_17740 ENOG410644B Stage III sporulation protein af BZ167_17760 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BZ167_17765 ENOG4108ZSR alkaline shock protein BZ167_17770 ENOG4105M7K Involved in the transcription termination process (By similarity) BZ167_17775 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BZ167_17780 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BZ167_17785 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BZ167_17790 ENOG4105CTB Polyprenyl synthetase BZ167_17795 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BZ167_17800 ENOG4105DX0 Hemolysin A BZ167_17805 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BZ167_17810 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BZ167_17815 ENOG4105S1Z Stage IV sporulation protein B BZ167_17820 ENOG4107QQR Sporulation BZ167_17825 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BZ167_17840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BZ167_17865 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BZ167_17870 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BZ167_17880 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BZ167_17885 ENOG4105C1G acyl-Coa dehydrogenase BZ167_17895 ENOG4105DXD 2-methylcitrate dehydratase BZ167_17900 ENOG4105CR4 methylisocitrate lyase BZ167_17905 ENOG4106CCJ Protein of unknown function (DUF2627) BZ167_17910 ENOG4108JUB Transcriptional regulator BZ167_17920 ENOG4107RDP Dehydrogenase BZ167_17925 ENOG4105CKM Branched-chain carboxylic acid kinase BZ167_17940 ENOG4105CPP Dehydrogenase, E1 component BZ167_17945 ENOG4105C7S Dehydrogenase BZ167_17950 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BZ167_17955 ENOG4108Y6J UPF0403 protein BZ167_17960 ENOG4108HW3 (ABC) transporter BZ167_17965 ENOG4105E5Q amino acid AbC transporter BZ167_17970 ENOG4105CDA abc transporter atp-binding protein BZ167_17975 ENOG4108QEG Membrane BZ167_17980 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BZ167_17985 ENOG4108ZVT methylmalonyl-coA epimerase BZ167_17990 ENOG4108HNZ carboxyl transferase BZ167_17995 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BZ167_18000 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BZ167_18010 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BZ167_18015 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BZ167_18020 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BZ167_18025 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BZ167_18030 ENOG410861F 50S ribosomal protein L33 BZ167_18040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BZ167_18055 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BZ167_18065 ENOG4107QKG PfaD family BZ167_18080 ENOG4105CEY Amp-dependent synthetase and ligase BZ167_18085 ENOG4105CHR reductase BZ167_18095 ENOG4105C0W non-ribosomal peptide synthetase BZ167_18105 ENOG4105C0W non-ribosomal peptide synthetase BZ167_18110 ENOG4105C0W non-ribosomal peptide synthetase BZ167_18125 ENOG4106A3M Cytochrome p-450 BZ167_18130 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BZ167_18135 ENOG4108KQ6 Enoyl-CoA hydratase BZ167_18140 ENOG4105II7 pyrroline-5-carboxylate reductase BZ167_18145 ENOG41069FQ Metallo-beta-lactamase superfamily BZ167_18150 ENOG4108IXY short-chain dehydrogenase reductase BZ167_18160 ENOG4105CS9 pantothenic acid kinase BZ167_18165 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BZ167_18170 ENOG4105C02 permease BZ167_18185 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BZ167_18190 ENOG4108XET gCN5-related N-acetyltransferase BZ167_18195 ENOG4105KAC Antibiotic biosynthesis monooxygenase BZ167_18200 ENOG4105RHY Pfam:UPF0157 BZ167_18205 ENOG4106HZJ BZ167_18225 ENOG4105CPC Aldo Keto reductase BZ167_18235 ENOG4108YZ4 nudix hydrolase BZ167_18245 ENOG4108IMY Transcriptional regulator BZ167_18250 ENOG4105HDK L-asparaginase BZ167_18255 ENOG4108IJ0 Aspartate ammonia-lyase BZ167_18260 ENOG4105DFD Na H antiporter BZ167_18280 ENOG4105MZ9 stage II sporulation protein m BZ167_18285 ENOG4105I3K Ferric uptake regulator, Fur family BZ167_18295 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BZ167_18300 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BZ167_18305 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BZ167_18310 ENOG4105DZ1 carboxypeptidase BZ167_18315 ENOG41082AN stage II sporulation protein BZ167_18320 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BZ167_18325 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BZ167_18340 ENOG41090VF Stage v sporulation protein ac BZ167_18345 ENOG4105CZ3 stage V sporulation protein ad BZ167_18355 ENOG4105G6R Stage v sporulation protein ae BZ167_18365 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BZ167_18370 ENOG4105PTM secreted protein BZ167_18375 ENOG4107ZE5 PPIases accelerate the folding of proteins BZ167_18400 ENOG4108R6K riboflavin synthase, subunit alpha BZ167_18405 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BZ167_18410 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BZ167_18435 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BZ167_18440 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BZ167_18450 ENOG4105DZ1 carboxypeptidase BZ167_18455 ENOG4108JIC nucleoside recognition domain protein BZ167_18465 ENOG4105FE9 pseudouridine synthase BZ167_18475 ENOG4107TWT Cytochrome c biogenesis protein BZ167_18480 ENOG4105CRE cytochrome C BZ167_18485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BZ167_18490 ENOG4105BZU Histidine kinase BZ167_18505 ENOG4108JQ1 Dehydrogenase BZ167_18510 ENOG4108SAX Membrane BZ167_18520 ENOG4105T7X BZ167_18525 ENOG4105C9U ATP-dependent DNA helicase RecQ BZ167_18530 ENOG4105I7S Abortive infection protein BZ167_18545 ENOG4107RGJ metallophosphoesterase BZ167_18560 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BZ167_18565 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BZ167_18575 ENOG4105MSI germination protein ypeb BZ167_18585 ENOG4105CAT Cytidine monophosphate kinase BZ167_18590 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BZ167_18610 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BZ167_18615 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BZ167_18630 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BZ167_18635 ENOG4105K70 DNA-binding protein BZ167_18640 ENOG4105EUJ GTP cyclohydrolase i BZ167_18645 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BZ167_18650 ENOG4105XXQ heptaprenyl diphosphate synthase component I BZ167_18655 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BZ167_18660 ENOG4105EAH synthase BZ167_18665 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BZ167_18670 ENOG4105BZU Histidine kinase BZ167_18675 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BZ167_18685 ENOG4105KHN chorismate mutase BZ167_18690 ENOG4105CRQ synthase (Component I) BZ167_18700 ENOG4105DK0 Indole-3-glycerol phosphate synthase BZ167_18705 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BZ167_18710 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BZ167_18720 ENOG4105CIH Imidazole acetol-phosphate transaminase BZ167_18730 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BZ167_18735 ENOG41068YB TPR repeat-containing protein BZ167_18755 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BZ167_18775 ENOG4105F0F Oxalate decarboxylase BZ167_18780 ENOG4108JYZ YitT family BZ167_18785 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BZ167_18790 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BZ167_18795 ENOG4108Z5K methylglyoxal synthase BZ167_18800 ENOG4105FJR Lmbe family BZ167_18805 ENOG4105CPK Glycosyl transferase (Group 1 BZ167_18810 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BZ167_18820 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BZ167_18830 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BZ167_18835 ENOG4105DVT helicase BZ167_18840 ENOG4105YAC BZ167_18850 ENOG4105CHM Aminotransferase BZ167_18855 ENOG4105C5S asparaginyl-tRNA synthetase BZ167_18865 ENOG4105CSM endonuclease III BZ167_18875 ENOG4105DQ6 Transposase BZ167_18885 ENOG4105BZ4 penicillin-binding protein BZ167_18890 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BZ167_18935 ENOG4108I5C dEAD DEAH box helicase BZ167_18940 ENOG4107X2U Inherit from COG: Exonuclease-like protein BZ167_18950 ENOG4108UKS UPF0398 protein BZ167_18955 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BZ167_18965 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BZ167_18980 ENOG4105DVT helicase BZ167_18985 ENOG4105CTD carboxy-peptidase BZ167_18990 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BZ167_18995 ENOG4105C2W permease BZ167_19030 ENOG41065KQ synthase BZ167_19040 ENOG410890F Dynamin family BZ167_19060 ENOG41081VK Ribonuclease BZ167_19100 ENOG4105CVG Homoserine O-transsuccinylase BZ167_19105 ENOG4108V06 Glutathione peroxidase BZ167_19120 ENOG4105C01 Dihydroxy-acid dehydratase BZ167_19125 ENOG4108Y6J UPF0403 protein BZ167_19130 ENOG4107YX5 Pfam:DUF548 BZ167_19140 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BZ167_19145 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BZ167_19155 ENOG4108UT2 hemolysin iii BZ167_19165 ENOG4105C7B Threonine dehydratase BZ167_19175 ENOG4108KF3 Electron transport protein SCO1 SenC BZ167_19180 ENOG41090WU lipolytic protein G-D-S-L family BZ167_19185 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BZ167_19195 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BZ167_19200 ENOG4105E0X reductase BZ167_19205 ENOG4105C5E polysaccharide biosynthesis protein BZ167_19245 ENOG4105FTQ Dna gyrase BZ167_19250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BZ167_19265 ENOG4107S4Y M20 DapE family protein YgeY BZ167_19270 ENOG4108TSC N-acetyltransferase BZ167_19275 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BZ167_19305 ENOG410841Q phosphoesterase PA-phosphatase related protein BZ167_19310 ENOG4106Z5R BZ167_19315 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BZ167_19320 ENOG4108VXD carboxy-peptidase BZ167_19340 ENOG4108S3Y transcriptional regulator BZ167_19345 ENOG4105CS2 ec 3.2.1.21 BZ167_19360 ENOG4105E1V na solute symporter BZ167_19375 ENOG4105FBA Phospholipase Carboxylesterase BZ167_19395 ENOG41090U3 tautomerase BZ167_19410 ENOG4105FR1 rard protein BZ167_19430 ENOG4106SCS STAS domain BZ167_19435 ENOG4107QMU Mate efflux family protein BZ167_19445 ENOG41087PP glycosyltransferase MGT family BZ167_19450 ENOG4105K4H Nlp p60 protein BZ167_19460 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BZ167_19465 ENOG4107T89 von Willebrand factor, type A BZ167_19470 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BZ167_19475 ENOG4105C7S Dehydrogenase BZ167_19485 ENOG4105C09 Bile acid BZ167_19490 ENOG4105C8J )-transporter BZ167_19495 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BZ167_19500 ENOG4105EWU Squalene--hopene cyclase BZ167_19505 ENOG4105C26 Dehydrogenase BZ167_19550 ENOG4105SCY DNAK suppressor BZ167_19555 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BZ167_19565 ENOG4105C9U ATP-dependent DNA helicase RecQ BZ167_19570 ENOG41069ER domain protein BZ167_19595 ENOG4108SJC Membrane BZ167_19605 ENOG4105KTU Transcriptional regulator, arsr family BZ167_19615 ENOG4108W8B Beta-lactamase domain protein BZ167_19625 ENOG4105FTV AraC Family Transcriptional Regulator BZ167_19630 ENOG4108Z7R Chaperone CsaA BZ167_19635 ENOG4106BHF BZ167_19640 ENOG4106ANW SMI1_KNR4 BZ167_19665 ENOG4108J2R molybdopterin oxidoreductase BZ167_19670 ENOG4108M3J Dehydrogenase BZ167_19675 ENOG4107U6E carbohydrate kinase FGGY BZ167_19680 ENOG4105IE8 Alpha-ketoglutarate permease BZ167_19685 ENOG4108UB7 BZ167_19700 ENOG4105DQ6 Transposase BZ167_19720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BZ167_19725 ENOG4105C5Q Transcriptional regulator BZ167_19730 ENOG4105CBC glutamate synthase BZ167_19735 ENOG4105BZ8 glutamate synthase BZ167_19740 ENOG4105CB2 alcohol dehydrogenase BZ167_19745 ENOG4108KSA LysR family transcriptional regulator BZ167_19750 ENOG4105C22 threonyL-tRNA synthetase BZ167_19755 ENOG4105WAB arsR family transcriptional regulator BZ167_19760 ENOG4108RWP Major Facilitator Superfamily protein BZ167_19765 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BZ167_19880 ENOG410682Q Phage transcriptional regulator, ArpU BZ167_19900 ENOG410682P Hypothetical protein (DUF2513) BZ167_19925 ENOG4105CAR Terminase, large subunit BZ167_20005 ENOG4107X35 defense response to bacterium BZ167_20015 ENOG41068G1 BZ167_20035 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BZ167_20060 ENOG4107QJQ Mate efflux family protein BZ167_20065 ENOG4108N2V aldose 1-epimerase BZ167_20070 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BZ167_20080 ENOG4105C0W non-ribosomal peptide synthetase