locus-tag	class	description
LCF45_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LCF45_00010	COG0592	DNA-directed DNA polymerase activity
LCF45_00015	COG2501	S4 domain
LCF45_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LCF45_00025	COG0187	DNA topoisomerase II activity
LCF45_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LCF45_00065	COG0517	IMP dehydrogenase activity
LCF45_00065	COG0516	GMP reductase activity
LCF45_00070	COG1686	Belongs to the peptidase S11 family
LCF45_00075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LCF45_00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LCF45_00100	COG1428	Deoxynucleoside kinase
LCF45_00105	COG1428	Deoxynucleoside kinase
LCF45_00110	COG1335	isochorismatase
LCF45_00115	COG0590	tRNA wobble adenosine to inosine editing
LCF45_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LCF45_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LCF45_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LCF45_00180	COG1982	Orn Lys Arg decarboxylase major
LCF45_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LCF45_00190	COG0470	DNA polymerase III
LCF45_00195	COG1774	PSP1 C-terminal conserved region
LCF45_00200	COG4467	Involved in initiation control of chromosome replication
LCF45_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LCF45_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LCF45_00220	COG2002	toxin-antitoxin pair type II binding
LCF45_00230	COG0084	hydrolase, TatD family'
LCF45_00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LCF45_00250	COG4466	Protein conserved in bacteria
LCF45_00260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LCF45_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LCF45_00270	COG0251	oxidation-reduction process
LCF45_00275	COG2088	sporulation resulting in formation of a cellular spore
LCF45_00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LCF45_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LCF45_00305	COG2002	toxin-antitoxin pair type II binding
LCF45_00310	COG2244	polysaccharide biosynthetic process
LCF45_00315	COG3956	TIGRFAM MazG family protein
LCF45_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LCF45_00340	COG1098	S1 RNA binding domain
LCF45_00355	COG2208	phosphoserine phosphatase activity
LCF45_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LCF45_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LCF45_00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LCF45_00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LCF45_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LCF45_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LCF45_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
LCF45_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LCF45_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LCF45_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LCF45_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LCF45_00420	COG1396	sequence-specific DNA binding
LCF45_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LCF45_00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LCF45_00515	COG3880	PFAM UvrB UvrC protein
LCF45_00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LCF45_00525	COG0542	response to heat
LCF45_00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LCF45_00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LCF45_00540	COG4956	integral membrane protein (PIN domain superfamily)
LCF45_00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LCF45_00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LCF45_00560	COG1045	serine acetyltransferase
LCF45_00565	COG0215	cysteine-tRNA ligase activity
LCF45_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCF45_00580	COG3688	RNA-binding protein containing a PIN domain
LCF45_00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LCF45_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LCF45_00600	COG0250	Participates in transcription elongation, termination and antitermination
LCF45_00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LCF45_00610	COG0081	regulation of translation
LCF45_00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LCF45_00620	COG0222	ribosome binding
LCF45_00625	COG2813	Specifically methylates the guanine in position
LCF45_00630	COG0085	RNA polymerase activity
LCF45_00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LCF45_00640	COG1358	cellular component organization or biogenesis
LCF45_00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LCF45_00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LCF45_00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LCF45_00665	COG0051	transcription antitermination factor activity, RNA binding
LCF45_00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LCF45_00675	COG0088	Forms part of the polypeptide exit tunnel
LCF45_00680	COG0089	rRNA binding
LCF45_00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LCF45_00690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LCF45_00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LCF45_00710	COG0255	Belongs to the universal ribosomal protein uL29 family
LCF45_00715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LCF45_00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LCF45_00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LCF45_00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LCF45_00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LCF45_00760	COG1841	ribosomal large subunit assembly
LCF45_00765	COG0200	Binds to the 23S rRNA
LCF45_00770	COG0201	protein transport
LCF45_00775	COG0563	adenylate kinase activity
LCF45_00780	COG0024	Methionine aminopeptidase
LCF45_00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LCF45_00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LCF45_00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LCF45_00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LCF45_00835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LCF45_00840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LCF45_00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCF45_00855	COG0489	protein tyrosine kinase activity
LCF45_00865	COG2194	sulfuric ester hydrolase activity
LCF45_00870	COG0726	polysaccharide deacetylase
LCF45_00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LCF45_00955	COG4856	YbbR-like protein
LCF45_00960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LCF45_00985	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_00990	COG2011	ABC-type metal ion transport system permease component
LCF45_01000	COG1464	Belongs to the NlpA lipoprotein family
LCF45_01005	COG0604	alcohol dehydrogenase
LCF45_01015	COG0277	FAD linked oxidase domain protein
LCF45_01020	COG2271	Major facilitator Superfamily
LCF45_01030	COG2814	Major facilitator Superfamily
LCF45_01050	COG0601	transmembrane transport
LCF45_01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCF45_01060	COG0444	Belongs to the ABC transporter superfamily
LCF45_01065	COG4608	Belongs to the ABC transporter superfamily
LCF45_01070	COG4166	transmembrane transport
LCF45_01080	COG2207	Transcriptional regulator
LCF45_01095	COG4166	transmembrane transport
LCF45_01100	COG4166	transmembrane transport
LCF45_01105	COG0656	L-ascorbic acid biosynthetic process
LCF45_01110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LCF45_01125	COG4149	molybdate abc transporter
LCF45_01130	COG0725	ABC transporter, periplasmic molybdate-binding protein
LCF45_01135	COG1910	domain protein
LCF45_01150	COG0697	spore germination
LCF45_01165	COG0204	Acyl-transferase
LCF45_01175	COG1609	Transcriptional regulator
LCF45_01185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_01200	COG5298	Protein conserved in bacteria
LCF45_01220	COG0488	(ABC) transporter
LCF45_01225	COG4585	Histidine kinase
LCF45_01230	COG2197	response regulator
LCF45_01235	COG1131	(ABC) transporter
LCF45_01240	COG0842	Transport permease protein
LCF45_01240	COG1511	domain protein
LCF45_01245	COG0842	Transport permease protein
LCF45_01255	COG0747	negative chemotaxis
LCF45_01265	COG0601	transmembrane transport
LCF45_01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCF45_01275	COG0444	Belongs to the ABC transporter superfamily
LCF45_01280	COG4608	Belongs to the ABC transporter superfamily
LCF45_01285	COG0561	phosphatase activity
LCF45_01315	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LCF45_01320	COG0179	Fumarylacetoacetate (FAA) hydrolase
LCF45_01330	COG0531	amino acid
LCF45_01335	COG2814	Major facilitator Superfamily
LCF45_01345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LCF45_01355	COG4294	response to UV
LCF45_01360	COG0705	Rhomboid family
LCF45_01365	COG0736	holo-[acyl-carrier-protein] synthase activity
LCF45_01370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LCF45_01380	COG0864	Transcriptional regulator
LCF45_01385	COG2337	Toxic component of a toxin-antitoxin (TA) module
LCF45_01390	COG2183	response to ionizing radiation
LCF45_01490	COG0802	atpase or kinase
LCF45_01495	COG1214	PFAM Peptidase M22, glycoprotease
LCF45_01500	COG0456	acetyltransferase
LCF45_01510	COG0488	(ABC) transporter
LCF45_01515	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LCF45_01525	COG1266	CAAX protease self-immunity
LCF45_01530	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LCF45_01540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LCF45_01540	COG0519	Catalyzes the synthesis of GMP from XMP
LCF45_01545	COG2252	PERMEase
LCF45_01555	COG5002	protein histidine kinase activity
LCF45_01580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LCF45_01610	COG2226	methyltransferase
LCF45_01620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LCF45_01630	COG1215	transferase activity, transferring glycosyl groups
LCF45_01675	COG2205	protein histidine kinase activity
LCF45_01680	COG0745	RESPONSE REGULATOR receiver
LCF45_01700	COG0697	spore germination
LCF45_01730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LCF45_01735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LCF45_01740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LCF45_01745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LCF45_01750	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LCF45_01755	COG0047	phosphoribosylformylglycinamidine synthase activity
LCF45_01760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LCF45_01765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LCF45_01770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LCF45_01775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LCF45_01780	COG0138	bifunctional purine biosynthesis protein purh
LCF45_01785	COG0151	Belongs to the GarS family
LCF45_01805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LCF45_01810	COG0210	DNA helicase
LCF45_01815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LCF45_01820	COG4851	CamS sex pheromone cAM373 precursor
LCF45_01830	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_01835	COG1335	isochorismatase
LCF45_01845	COG2011	ABC-type metal ion transport system permease component
LCF45_01850	COG1464	Belongs to the NlpA lipoprotein family
LCF45_01865	COG0003	Pfam Anion-transporting ATPase
LCF45_01870	COG1846	Transcriptional regulator
LCF45_01875	COG4682	membrane
LCF45_01885	COG0154	amidase activity
LCF45_01890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LCF45_01895	COG1597	lipid kinase activity
LCF45_01905	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LCF45_01915	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_01920	COG2076	Multidrug Resistance protein
LCF45_01925	COG2309	aminopeptidase activity
LCF45_01940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCF45_01950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LCF45_01955	COG5002	protein histidine kinase activity
LCF45_01960	COG4807	Protein conserved in bacteria
LCF45_01985	COG1757	Na H antiporter
LCF45_01990	COG1473	amidohydrolase
LCF45_02005	COG0450	alkyl hydroperoxide reductase
LCF45_02015	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LCF45_02025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_02030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_02035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_02040	COG0492	ferredoxin-NADP+ reductase activity
LCF45_02050	COG0166	Belongs to the GPI family
LCF45_02075	COG5002	protein histidine kinase activity
LCF45_02095	COG3541	Predicted nucleotidyltransferase
LCF45_02100	COG2814	Major facilitator Superfamily
LCF45_02105	COG0723	plastoquinol--plastocyanin reductase activity
LCF45_02105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCF45_02115	COG0765	amino acid transport
LCF45_02120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCF45_02130	COG0840	transmembrane signaling receptor activity
LCF45_02130	COG3290	protein histidine kinase activity
LCF45_02135	COG0277	FAD linked oxidase domain protein
LCF45_02140	COG0366	Alpha amylase catalytic
LCF45_02145	COG1263	PTS System
LCF45_02145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCF45_02145	COG2190	(PTS) system
LCF45_02165	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LCF45_02170	COG0352	thiamine-phosphate diphosphorylase activity
LCF45_02175	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LCF45_02190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCF45_02200	COG1116	anion transmembrane transporter activity
LCF45_02205	COG0488	(ABC) transporter
LCF45_02250	COG2270	Major facilitator Superfamily
LCF45_02280	COG2310	stress, protein
LCF45_02285	COG2310	stress, protein
LCF45_02290	COG2310	stress, protein
LCF45_02295	COG0861	Integral membrane protein TerC family
LCF45_02305	COG3853	Toxic anion resistance protein (TelA)
LCF45_02315	COG4840	Belongs to the UPF0435 family
LCF45_02320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LCF45_02330	COG1295	ribonuclease BN
LCF45_02335	COG2217	Heavy metal translocating P-type atpase
LCF45_02340	COG0697	spore germination
LCF45_02360	COG0586	Pfam SNARE associated Golgi protein
LCF45_02375	COG3871	stress protein (general stress protein 26)
LCF45_02380	COG0387	Pfam Sodium calcium exchanger
LCF45_02390	COG0535	radical SAM domain protein
LCF45_02410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LCF45_02430	COG3829	transcription factor binding
LCF45_02440	COG0833	amino acid
LCF45_02445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LCF45_02465	COG2066	Belongs to the glutaminase family
LCF45_02470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCF45_02470	COG1263	PTS System
LCF45_02475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LCF45_02490	COG1216	Glycosyl transferase, family 2
LCF45_02500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LCF45_02500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LCF45_02505	COG0463	Glycosyl transferase, family 2
LCF45_02520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LCF45_02525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LCF45_02540	COG1228	amidohydrolase
LCF45_02545	COG1090	epimerase
LCF45_02550	COG2137	regulation of response to DNA damage stimulus
LCF45_02575	COG1988	membrane-bound metal-dependent
LCF45_02580	COG1194	a g-specific adenine glycosylase
LCF45_02600	COG3557	Belongs to the UPF0374 family
LCF45_02605	COG1132	(ABC) transporter
LCF45_02610	COG4129	membrane
LCF45_02615	COG0067	glutamate synthase
LCF45_02615	COG0069	glutamate synthase activity
LCF45_02615	COG0070	glutamate synthase
LCF45_02620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LCF45_02625	COG4555	ABC transporter
LCF45_02645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LCF45_02650	COG0735	belongs to the Fur family
LCF45_02770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LCF45_02775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LCF45_02795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LCF45_02805	COG2766	serine protein kinase
LCF45_02810	COG2718	Belongs to the UPF0229 family
LCF45_02825	COG1585	Membrane protein implicated in regulation of membrane protease activity
LCF45_02830	COG2268	Band 7 protein
LCF45_02840	COG3290	protein histidine kinase activity
LCF45_02845	COG4565	transcriptional regulatory protein
LCF45_02850	COG2851	Citrate transporter
LCF45_02875	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LCF45_02880	COG3842	ATPase activity
LCF45_02885	COG1175	transmembrane transport
LCF45_02890	COG0395	ABC-type sugar transport system, permease component
LCF45_02900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LCF45_02905	COG0745	RESPONSE REGULATOR receiver
LCF45_02910	COG5002	protein histidine kinase activity
LCF45_02920	COG4990	cell redox homeostasis
LCF45_02930	COG3290	protein histidine kinase activity
LCF45_02935	COG4565	transcriptional regulatory protein
LCF45_02940	COG3493	citrate carrier protein
LCF45_02945	COG0281	malic enzyme
LCF45_02955	COG0697	spore germination
LCF45_02960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_02970	COG5002	protein histidine kinase activity
LCF45_02975	COG0745	RESPONSE REGULATOR receiver
LCF45_02980	COG0456	acetyltransferase
LCF45_02985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LCF45_02990	COG3383	formate dehydrogenase (NAD+) activity
LCF45_02995	COG2427	Protein of unknown function (DUF1641)
LCF45_03010	COG0531	amino acid
LCF45_03020	COG0640	Transcriptional regulator
LCF45_03025	COG2217	Heavy metal translocating P-type atpase
LCF45_03030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LCF45_03045	COG3227	Zinc metalloprotease (Elastase)
LCF45_03065	COG2720	vancomycin resistance protein
LCF45_03070	COG1316	TRANSCRIPTIONal
LCF45_03075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCF45_03080	COG0346	lactoylglutathione lyase activity
LCF45_03085	COG1253	flavin adenine dinucleotide binding
LCF45_03090	COG1027	Aspartate ammonia-lyase
LCF45_03095	COG1620	l-lactate permease
LCF45_03100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCF45_03115	COG3104	oligopeptide transport
LCF45_03120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_03125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_03130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_03145	COG0156	8-amino-7-oxononanoate synthase activity
LCF45_03150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LCF45_03160	COG4548	von Willebrand factor, type A
LCF45_03165	COG0714	Associated with various cellular activities
LCF45_03185	COG0531	amino acid
LCF45_03190	COG2188	Transcriptional regulator
LCF45_03195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCF45_03195	COG1263	PTS System
LCF45_03200	COG0366	Alpha amylase catalytic
LCF45_03215	COG0697	spore germination
LCF45_03220	COG4585	Histidine kinase
LCF45_03225	COG2197	response regulator
LCF45_03230	COG1404	Belongs to the peptidase S8 family
LCF45_03245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LCF45_03250	COG1115	amino acid carrier protein
LCF45_03255	COG1126	abc transporter atp-binding protein
LCF45_03260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCF45_03265	COG0765	amino acid transport
LCF45_03270	COG0765	amino acid transport
LCF45_03275	COG0833	amino acid
LCF45_03285	COG2378	regulation of single-species biofilm formation
LCF45_03290	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LCF45_03295	COG5002	protein histidine kinase activity
LCF45_03310	COG0659	secondary active sulfate transmembrane transporter activity
LCF45_03325	COG2271	Major facilitator Superfamily
LCF45_03330	COG1846	Transcriptional regulator
LCF45_03335	COG0477	Major facilitator Superfamily
LCF45_03340	COG1609	Transcriptional regulator
LCF45_03345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCF45_03350	COG1869	D-ribose catabolic process
LCF45_03360	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCF45_03365	COG1879	ABC-type sugar transport system periplasmic component
LCF45_03395	COG1063	alcohol dehydrogenase
LCF45_03410	COG3568	Endonuclease Exonuclease Phosphatase
LCF45_03440	COG0840	transmembrane signaling receptor activity
LCF45_03445	COG1388	LysM domain
LCF45_03445	COG3584	3D domain protein
LCF45_03450	COG1476	TRANSCRIPTIONal
LCF45_03470	COG3104	oligopeptide transport
LCF45_03475	COG1114	Component of the transport system for branched-chain amino acids
LCF45_03490	COG1113	amino acid transport
LCF45_03495	COG2252	PERMEase
LCF45_03520	COG0475	glutathione-regulated potassium exporter activity
LCF45_03520	COG0569	domain protein
LCF45_03530	COG1845	cytochrome c oxidase, subunit III
LCF45_03535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LCF45_03545	COG0833	amino acid
LCF45_03550	COG4990	cell redox homeostasis
LCF45_03565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCF45_03570	COG0697	spore germination
LCF45_03575	COG0531	amino acid
LCF45_03585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LCF45_03590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LCF45_03600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LCF45_03605	COG0573	inorganic phosphate transmembrane transporter activity
LCF45_03610	COG0581	inorganic phosphate transmembrane transporter activity
LCF45_03620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCF45_03740	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LCF45_03755	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCF45_03755	COG3103	Sh3 type 3 domain protein
LCF45_03755	COG4991	sh3 domain protein
LCF45_03760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LCF45_03765	COG1116	anion transmembrane transporter activity
LCF45_03770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCF45_03775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCF45_03780	COG0352	thiamine-phosphate diphosphorylase activity
LCF45_03785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCF45_03790	COG2104	thiamine diphosphate biosynthetic process
LCF45_03795	COG2022	thiamine diphosphate biosynthetic process
LCF45_03800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LCF45_03805	COG0351	phosphomethylpyrimidine kinase
LCF45_03830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LCF45_03835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LCF45_03840	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LCF45_03845	COG2205	protein histidine kinase activity
LCF45_03850	COG2814	Major facilitator Superfamily
LCF45_03855	COG1846	Transcriptional regulator
LCF45_03875	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCF45_03880	COG1129	ABC transporter
LCF45_03885	COG1879	ABC-type sugar transport system periplasmic component
LCF45_03890	COG2252	PERMEase
LCF45_03895	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_03910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LCF45_03915	COG1621	beta-fructofuranosidase activity
LCF45_03920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCF45_03920	COG1263	PTS System
LCF45_03925	COG1609	Transcriptional regulator
LCF45_03975	COG0778	Nitroreductase
LCF45_03980	COG2719	SpoVR family
LCF45_04000	COG1937	Protein conserved in bacteria
LCF45_04005	COG0425	Belongs to the sulfur carrier protein TusA family
LCF45_04005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCF45_04010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCF45_04010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCF45_04015	COG0425	Belongs to the sulfur carrier protein TusA family
LCF45_04020	COG0425	Belongs to the sulfur carrier protein TusA family
LCF45_04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCF45_04025	COG2210	Belongs to the sulfur carrier protein TusA family
LCF45_04030	COG0730	response to heat
LCF45_04040	COG1316	TRANSCRIPTIONal
LCF45_04045	COG0604	alcohol dehydrogenase
LCF45_04050	COG1283	sodium-dependent phosphate transmembrane transporter activity
LCF45_04055	COG0604	alcohol dehydrogenase
LCF45_04060	COG2814	Major facilitator Superfamily
LCF45_04070	COG3711	transcriptional antiterminator
LCF45_04070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCF45_04075	COG1447	Phosphotransferase system cellobiose-specific component IIA
LCF45_04080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LCF45_04105	COG3584	3D domain protein
LCF45_04105	COG1388	LysM domain
LCF45_04110	COG0577	efflux transmembrane transporter activity
LCF45_04115	COG1136	(ABC) transporter
LCF45_04125	COG5522	Integral membrane protein (intg_mem_TP0381)
LCF45_04140	COG1114	Component of the transport system for branched-chain amino acids
LCF45_04145	COG3546	catalase activity
LCF45_04175	COG0586	Pfam SNARE associated Golgi protein
LCF45_04205	COG0531	amino acid
LCF45_04210	COG0475	glutathione-regulated potassium exporter activity
LCF45_04220	COG1737	Transcriptional regulator
LCF45_04225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LCF45_04230	COG1263	PTS System
LCF45_04230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCF45_04240	COG2259	Doxx family
LCF45_04260	COG0697	spore germination
LCF45_04265	COG1522	sequence-specific DNA binding
LCF45_04275	COG0300	oxidoreductase activity
LCF45_04290	COG2076	Multidrug Resistance protein
LCF45_04295	COG1309	transcriptional regulator
LCF45_04300	COG2814	Major facilitator Superfamily
LCF45_04305	COG1733	regulation of RNA biosynthetic process
LCF45_04320	COG4533	DNA binding
LCF45_04325	COG2211	Major facilitator Superfamily
LCF45_04335	COG0693	protein deglycase activity
LCF45_04345	COG0531	amino acid
LCF45_04350	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_04355	COG1132	(ABC) transporter
LCF45_04360	COG1132	(ABC) transporter
LCF45_04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCF45_04370	COG0765	amino acid transport
LCF45_04375	COG1126	abc transporter atp-binding protein
LCF45_04390	COG0189	ligase activity
LCF45_04400	COG4399	Belongs to the UPF0754 family
LCF45_04405	COG3679	Belongs to the UPF0342 family
LCF45_04420	COG0028	Belongs to the TPP enzyme family
LCF45_04425	COG3527	Alpha-acetolactate decarboxylase
LCF45_04430	COG0463	Glycosyl transferase, family 2
LCF45_04435	COG1216	Glycosyl transferase, family 2
LCF45_04440	COG2094	Belongs to the DNA glycosylase MPG family
LCF45_04445	COG0561	phosphatase activity
LCF45_04455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCF45_04460	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_04470	COG0659	secondary active sulfate transmembrane transporter activity
LCF45_04485	COG0653	protein targeting
LCF45_04490	COG2244	polysaccharide biosynthetic process
LCF45_04500	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCF45_04520	COG1696	Membrane protein involved in D-alanine export
LCF45_04535	COG1024	Enoyl-CoA hydratase
LCF45_04550	COG1363	Peptidase, m42
LCF45_04565	COG2318	DinB family
LCF45_04590	COG0579	oxidoreductase
LCF45_04625	COG0601	transmembrane transport
LCF45_04630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCF45_04635	COG0444	Belongs to the ABC transporter superfamily
LCF45_04640	COG4608	Belongs to the ABC transporter superfamily
LCF45_04730	COG0477	Major facilitator Superfamily
LCF45_04735	COG3290	protein histidine kinase activity
LCF45_04740	COG4565	transcriptional regulatory protein
LCF45_04745	COG3181	Tripartite tricarboxylate transporter family receptor
LCF45_04815	COG0732	type I restriction modification DNA specificity domain
LCF45_04820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LCF45_04875	COG0305	Participates in initiation and elongation during chromosome replication
LCF45_04905	COG0477	Major facilitator Superfamily
LCF45_04940	COG3711	transcriptional antiterminator
LCF45_04945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCF45_04945	COG1263	PTS System
LCF45_04945	COG2190	(PTS) system
LCF45_04950	COG2723	6-phospho-beta-galactosidase activity
LCF45_04955	COG0456	acetyltransferase
LCF45_04965	COG1183	phosphatidylcholine synthase activity
LCF45_05030	COG2814	Major facilitator Superfamily
LCF45_05035	COG0640	Transcriptional regulator
LCF45_05055	COG2376	Dihydroxyacetone kinase
LCF45_05065	COG2376	Dihydroxyacetone kinase
LCF45_05080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCF45_05130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCF45_05135	COG1278	Cold shock
LCF45_05145	COG4932	domain protein
LCF45_05145	COG3266	domain, Protein
LCF45_05145	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LCF45_05150	COG0737	Belongs to the 5'-nucleotidase family
LCF45_05150	COG1525	nuclease
LCF45_05150	COG4085	toxin activity
LCF45_05185	COG0825	malonyl-CoA metabolic process
LCF45_05205	COG3237	CsbD-like
LCF45_05225	COG2172	sigma factor antagonist activity
LCF45_05230	COG1191	sigma factor activity
LCF45_05240	COG2208	phosphoserine phosphatase activity
LCF45_05245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LCF45_05250	COG0784	Response regulator, receiver
LCF45_05250	COG2205	protein histidine kinase activity
LCF45_05250	COG5002	protein histidine kinase activity
LCF45_05295	COG2807	transmembrane transport
LCF45_05300	COG2186	Transcriptional regulator
LCF45_05305	COG4585	Histidine kinase
LCF45_05310	COG2197	response regulator
LCF45_05340	COG0420	3'-5' exonuclease activity
LCF45_05345	COG4717	serine-type aminopeptidase activity
LCF45_05350	COG3481	metal-dependent phosphohydrolase, HD sub domain
LCF45_05360	COG0346	lactoylglutathione lyase activity
LCF45_05375	COG2267	carboxylic ester hydrolase activity
LCF45_05400	COG3620	sequence-specific DNA binding
LCF45_05405	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LCF45_05410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LCF45_05415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LCF45_05420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LCF45_05425	COG1595	DNA-templated transcription, initiation
LCF45_05440	COG3973	AAA domain
LCF45_05460	COG1846	Transcriptional regulator
LCF45_05470	COG0537	adenosine 5'-monophosphoramidase activity
LCF45_05475	COG1131	(ABC) transporter
LCF45_05480	COG4473	ABC transporter
LCF45_05490	COG0247	lactate metabolic process
LCF45_05495	COG1139	Iron-sulfur cluster binding protein
LCF45_05500	COG1556	Lactate utilization protein
LCF45_05520	COG3402	PFAM membrane-flanked domain
LCF45_05525	COG3428	Bacterial PH domain
LCF45_05555	COG3402	PFAM membrane-flanked domain
LCF45_05560	COG3428	Bacterial PH domain
LCF45_05565	COG2329	Antibiotic biosynthesis monooxygenase
LCF45_05570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCF45_05575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LCF45_05580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LCF45_05585	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LCF45_05605	COG1309	transcriptional regulator
LCF45_05610	COG1511	domain protein
LCF45_05645	COG2378	regulation of single-species biofilm formation
LCF45_05650	COG1609	Transcriptional regulator
LCF45_05660	COG1234	tRNA 3'-trailer cleavage
LCF45_05665	COG0095	Lipoate-protein ligase
LCF45_05675	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_05690	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LCF45_05695	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LCF45_05700	COG4208	sulfate ABC transporter
LCF45_05715	COG1408	metallophosphoesterase
LCF45_05720	COG1078	dGTPase activity
LCF45_05735	COG1595	DNA-templated transcription, initiation
LCF45_05740	COG3708	Transcriptional regulator
LCF45_05740	COG2207	Transcriptional regulator
LCF45_05745	COG2205	protein histidine kinase activity
LCF45_05750	COG0745	RESPONSE REGULATOR receiver
LCF45_05765	COG0501	Belongs to the peptidase M48B family
LCF45_05770	COG0697	spore germination
LCF45_05795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LCF45_05800	COG2224	Isocitrate lyase
LCF45_05810	COG1278	Cold shock
LCF45_05825	COG4903	ComK protein
LCF45_05830	COG0398	Pfam SNARE associated Golgi protein
LCF45_05840	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LCF45_05845	COG1074	ATP-dependent DNA helicase activity
LCF45_05895	COG0179	Fumarylacetoacetate (FAA) hydrolase
LCF45_05920	COG0367	asparagine synthase
LCF45_05930	COG0753	catalase activity
LCF45_05935	COG0004	ammonium transporteR
LCF45_05945	COG1666	GTP binding
LCF45_05950	COG2996	Protein conserved in bacteria
LCF45_05955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCF45_05965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_05980	COG0561	phosphatase activity
LCF45_06000	COG2267	carboxylic ester hydrolase activity
LCF45_06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCF45_06020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LCF45_06025	COG5504	Zn-dependent protease
LCF45_06035	COG0180	Tryptophanyl-tRNA synthetase
LCF45_06045	COG4166	transmembrane transport
LCF45_06050	COG0601	transmembrane transport
LCF45_06055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LCF45_06060	COG0444	Belongs to the ABC transporter superfamily
LCF45_06065	COG4608	Belongs to the ABC transporter superfamily
LCF45_06070	COG0534	Mate efflux family protein
LCF45_06075	COG4166	transmembrane transport
LCF45_06090	COG0861	Integral membrane protein TerC family
LCF45_06095	COG4862	establishment of competence for transformation
LCF45_06100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCF45_06110	COG1164	Oligoendopeptidase f
LCF45_06125	COG2346	COG2346, Truncated hemoglobins
LCF45_06130	COG4116	CYTH
LCF45_06140	COG2357	RelA SpoT domain protein
LCF45_06150	COG0564	pseudouridine synthase activity
LCF45_06160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LCF45_06165	COG0772	Belongs to the SEDS family
LCF45_06170	COG1216	Glycosyl transferase, family 2
LCF45_06175	COG2226	methyltransferase
LCF45_06190	COG0457	Tetratricopeptide repeat
LCF45_06190	COG0463	Glycosyl transferase, family 2
LCF45_06210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LCF45_06225	COG1091	dTDP-4-dehydrorhamnose reductase activity
LCF45_06270	COG2153	protein acetylation
LCF45_06275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LCF45_06280	COG2382	esterase
LCF45_06305	COG5492	domain, Protein
LCF45_06310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCF45_06320	COG0512	Glutamine amidotransferase of anthranilate synthase
LCF45_06320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LCF45_06325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LCF45_06330	COG0134	indole-3-glycerol-phosphate synthase activity
LCF45_06335	COG0135	phosphoribosylanthranilate isomerase activity
LCF45_06340	COG0133	tryptophan synthase activity
LCF45_06345	COG0159	tryptophan synthase activity
LCF45_06355	COG1620	l-lactate permease
LCF45_06360	COG5634	Uncharacterized conserved protein (DUF2278)
LCF45_06405	COG2226	methyltransferase
LCF45_06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCF45_06430	COG0567	Dehydrogenase, E1 component
LCF45_06435	COG1476	TRANSCRIPTIONal
LCF45_06460	COG4152	abc transporter atp-binding protein
LCF45_06465	COG1668	transmembrane transport
LCF45_06485	COG1686	Belongs to the peptidase S11 family
LCF45_06490	COG0681	Belongs to the peptidase S26 family
LCF45_06525	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_06535	COG1176	ABC-type spermidine putrescine transport system, permease component I
LCF45_06540	COG1177	transmembrane transport
LCF45_06545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LCF45_06555	COG2409	Drug exporters of the RND superfamily
LCF45_06565	COG0564	pseudouridine synthase activity
LCF45_06575	COG2340	Cysteine-rich secretory protein family
LCF45_06580	COG0247	lactate metabolic process
LCF45_06585	COG0277	FAD linked oxidase domain protein
LCF45_06590	COG3835	regulator
LCF45_06600	COG0745	RESPONSE REGULATOR receiver
LCF45_06605	COG5002	protein histidine kinase activity
LCF45_06610	COG2186	Transcriptional regulator
LCF45_06615	COG0247	lactate metabolic process
LCF45_06620	COG1139	Iron-sulfur cluster binding protein
LCF45_06625	COG1556	Lactate utilization protein
LCF45_06630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LCF45_06640	COG2116	formate transmembrane transporter activity
LCF45_06645	COG0861	Integral membrane protein TerC family
LCF45_06650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LCF45_06660	COG2030	dehydratase
LCF45_06680	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_06685	COG3243	poly(R)-hydroxyalkanoic acid synthase
LCF45_06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LCF45_06710	COG1840	ABC-type Fe3 transport system, periplasmic component
LCF45_06715	COG3842	ATPase activity
LCF45_06725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCF45_06730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LCF45_06740	COG1349	DNA-binding transcription factor activity
LCF45_06750	COG0235	Class ii aldolase
LCF45_06760	COG2861	carbohydrate metabolic process
LCF45_06770	COG3852	Histidine kinase
LCF45_06775	COG1846	Transcriptional regulator
LCF45_06785	COG2318	DinB family
LCF45_06795	COG5002	protein histidine kinase activity
LCF45_06800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LCF45_06805	COG0720	synthase
LCF45_06815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LCF45_06820	COG4873	Protein conserved in bacteria
LCF45_06835	COG0456	acetyltransferase
LCF45_06850	COG1780	Probably involved in ribonucleotide reductase function
LCF45_06865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LCF45_06870	COG0531	amino acid
LCF45_06875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LCF45_06890	COG2204	response regulator
LCF45_06895	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_06905	COG1725	Transcriptional regulator
LCF45_06910	COG1131	(ABC) transporter
LCF45_06920	COG1131	(ABC) transporter
LCF45_06925	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LCF45_06930	COG1266	CAAX protease self-immunity
LCF45_06940	COG1522	sequence-specific DNA binding
LCF45_06950	COG1335	isochorismatase
LCF45_06960	COG1619	proteins homologs of microcin C7 resistance protein MccF
LCF45_06965	COG2070	2-Nitropropane dioxygenase
LCF45_06970	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LCF45_06975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LCF45_06980	COG1696	Membrane protein involved in D-alanine export
LCF45_07005	COG0716	FMN binding
LCF45_07040	COG0534	Mate efflux family protein
LCF45_07045	COG1968	undecaprenyl-diphosphatase activity
LCF45_07065	COG1846	Transcriptional regulator
LCF45_07075	COG1301	dicarboxylic acid transport
LCF45_07080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LCF45_07090	COG3874	Sporulation protein YtfJ
LCF45_07110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LCF45_07115	COG0028	Belongs to the TPP enzyme family
LCF45_07120	COG0440	acetolactate synthase activity
LCF45_07130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LCF45_07140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LCF45_07150	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LCF45_07155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LCF45_07165	COG0131	Imidazoleglycerol-phosphate dehydratase
LCF45_07170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LCF45_07175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LCF45_07180	COG0107	imidazoleglycerol-phosphate synthase activity
LCF45_07190	COG0140	phosphoribosyl-ATP diphosphatase activity
LCF45_07195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LCF45_07210	COG1183	phosphatidylcholine synthase activity
LCF45_07215	COG1368	sulfuric ester hydrolase activity
LCF45_07225	COG0019	diaminopimelate decarboxylase activity
LCF45_07235	COG0175	sulfate reduction
LCF45_07240	COG2046	Belongs to the sulfate adenylyltransferase family
LCF45_07245	COG0529	Catalyzes the synthesis of activated sulfate
LCF45_07250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCF45_07270	COG1648	precorrin-2 dehydrogenase activity
LCF45_07275	COG0733	neurotransmitter:sodium symporter activity
LCF45_07300	COG1757	Na H antiporter
LCF45_07315	COG4758	membrane
LCF45_07320	COG4585	Histidine kinase
LCF45_07325	COG2197	response regulator
LCF45_07335	COG1114	Component of the transport system for branched-chain amino acids
LCF45_07345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LCF45_07385	COG0730	response to heat
LCF45_07390	COG0306	phosphate transporter
LCF45_07395	COG1392	Phosphate transport regulator
LCF45_07400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCF45_07415	COG3852	Histidine kinase
LCF45_07420	COG1801	Protein of unknown function DUF72
LCF45_07430	COG0582	viral genome integration into host DNA
LCF45_07435	COG5002	protein histidine kinase activity
LCF45_07450	COG0392	lysyltransferase activity
LCF45_07450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LCF45_07465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LCF45_07470	COG1686	Belongs to the peptidase S11 family
LCF45_07475	COG2715	membrane protein required for spore maturation
LCF45_07480	COG0700	Nucleoside recognition
LCF45_07485	COG1187	pseudouridine synthase activity
LCF45_07495	COG1333	cytochrome c biogenesis protein
LCF45_07500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LCF45_07505	COG0745	RESPONSE REGULATOR receiver
LCF45_07510	COG5002	protein histidine kinase activity
LCF45_07515	COG2096	Adenosyltransferase
LCF45_07520	COG4942	peptidase
LCF45_07530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LCF45_07535	COG1141	Ferredoxin
LCF45_07540	COG4955	Helix-turn-helix domain
LCF45_07545	COG0514	ATP-dependent DNA helicase (RecQ)
LCF45_07550	COG1266	CAAX protease self-immunity
LCF45_07560	COG1408	metallophosphoesterase
LCF45_07575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LCF45_07595	COG0492	ferredoxin-NADP+ reductase activity
LCF45_07600	COG0252	asparaginase activity
LCF45_07610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LCF45_07620	COG1304	FMN binding
LCF45_07650	COG1160	GTP binding
LCF45_07655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LCF45_07675	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LCF45_07690	COG0142	geranyltranstransferase activity
LCF45_07695	COG2226	methyltransferase
LCF45_07700	COG0142	geranyltranstransferase activity
LCF45_07725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LCF45_07730	COG0457	Tetratricopeptide repeat
LCF45_07735	COG5582	Belongs to the UPF0302 family
LCF45_07750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LCF45_07765	COG4347	Protein of unknown function (DUF1405)
LCF45_07780	COG2738	Putative neutral zinc metallopeptidase
LCF45_07790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_07795	COG1694	Mazg nucleotide pyrophosphohydrolase
LCF45_07800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LCF45_07805	COG1803	Methylglyoxal synthase
LCF45_07810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LCF45_07815	COG0438	transferase activity, transferring glycosyl groups
LCF45_07820	COG0617	tRNA 3'-terminal CCA addition
LCF45_07830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LCF45_07835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LCF45_07845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LCF45_07845	COG1199	ATP-dependent helicase activity
LCF45_07865	COG3935	DnaD domain protein
LCF45_07870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LCF45_07880	COG4499	WXG100 protein secretion system (Wss), protein YukC
LCF45_07880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCF45_07885	COG3331	DNA recombination
LCF45_07920	COG4474	Belongs to the UPF0398 family
LCF45_07925	COG3599	regulation of cell shape
LCF45_07935	COG0116	Belongs to the methyltransferase superfamily
LCF45_07945	COG1199	ATP-dependent helicase activity
LCF45_07950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LCF45_07960	COG0024	Methionine aminopeptidase
LCF45_07970	COG2233	PERMEase
LCF45_07975	COG2311	Membrane
LCF45_07980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LCF45_07990	COG0456	acetyltransferase
LCF45_08000	COG2897	thiosulfate sulfurtransferase activity
LCF45_08040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCF45_08055	COG0454	-acetyltransferase
LCF45_08075	COG0328	RNA-DNA hybrid ribonuclease activity
LCF45_08110	COG3403	YqcI/YcgG family
LCF45_08115	COG1280	lysine exporter protein (LysE YggA)
LCF45_08130	COG3162	membrane
LCF45_08135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LCF45_08140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LCF45_08150	COG0475	glutathione-regulated potassium exporter activity
LCF45_08155	COG0789	Transcriptional regulator
LCF45_08155	COG4978	Transcriptional regulator
LCF45_08165	COG2323	membrane
LCF45_08170	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LCF45_08220	COG1923	regulation of RNA biosynthetic process
LCF45_08230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LCF45_08235	COG1360	Flagellar Motor Protein
LCF45_08240	COG2201	protein-glutamate methylesterase activity
LCF45_08245	COG0643	Histidine kinase
LCF45_08245	COG2198	Histidine kinase
LCF45_08250	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LCF45_08250	COG1776	CheC inhibitor of MCP methylation
LCF45_08265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LCF45_08285	COG1256	bacterial-type flagellum assembly
LCF45_08290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LCF45_08310	COG1815	bacterial-type flagellum-dependent cell motility
LCF45_08315	COG1558	bacterial-type flagellum-dependent cell motility
LCF45_08325	COG1766	The M ring may be actively involved in energy transduction
LCF45_08330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LCF45_08340	COG1157	protein secretion by the type III secretion system
LCF45_08360	COG1749	Flagellar hook protein flgE
LCF45_08375	COG0835	chemotaxis
LCF45_08375	COG0784	Response regulator, receiver
LCF45_08395	COG0861	Integral membrane protein TerC family
LCF45_08405	COG3383	formate dehydrogenase (NAD+) activity
LCF45_08410	COG2427	Protein of unknown function (DUF1641)
LCF45_08415	COG5609	conserved protein (DUF2294)
LCF45_08420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LCF45_08430	COG2116	formate transmembrane transporter activity
LCF45_08435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LCF45_08440	COG0303	'Molybdopterin
LCF45_08445	COG0314	molybdopterin synthase activity
LCF45_08450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LCF45_08460	COG0489	protein tyrosine kinase activity
LCF45_08475	COG0741	lytic transglycosylase activity
LCF45_08485	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LCF45_08490	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LCF45_08490	COG1776	CheC inhibitor of MCP methylation
LCF45_08500	COG1338	Plays a role in the flagellum-specific transport system
LCF45_08505	COG1987	bacterial-type flagellum assembly
LCF45_08515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LCF45_08520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LCF45_08525	COG1419	protein localization to endoplasmic reticulum
LCF45_08530	COG4786	Flagellar basal body rod
LCF45_08535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCF45_08565	COG0412	Dienelactone hydrolase
LCF45_08570	COG2329	Antibiotic biosynthesis monooxygenase
LCF45_08585	COG2814	Major facilitator Superfamily
LCF45_08595	COG0583	DNA-binding transcription factor activity
LCF45_08600	COG3842	ATPase activity
LCF45_08650	COG0406	alpha-ribazole phosphatase activity
LCF45_08680	COG0367	asparagine synthase
LCF45_08710	COG1802	Transcriptional regulator
LCF45_08715	COG0697	spore germination
LCF45_08730	COG0438	transferase activity, transferring glycosyl groups
LCF45_08730	COG1216	Glycosyl transferase, family 2
LCF45_08735	COG1757	Na H antiporter
LCF45_08745	COG0277	FAD linked oxidase domain protein
LCF45_08765	COG0534	Mate efflux family protein
LCF45_08770	COG3340	Belongs to the peptidase S51 family
LCF45_08790	COG0785	Cytochrome C biogenesis protein
LCF45_08795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCF45_08810	COG3048	D-serine ammonia-lyase activity
LCF45_08815	COG2733	membrane
LCF45_08835	COG1595	DNA-templated transcription, initiation
LCF45_08850	COG1131	(ABC) transporter
LCF45_08865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCF45_08910	COG0528	UMP kinase activity
LCF45_08920	COG1027	Aspartate ammonia-lyase
LCF45_08925	COG0281	malic enzyme
LCF45_08930	COG4191	Histidine kinase
LCF45_08935	COG0784	Response regulator, receiver
LCF45_08940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LCF45_08950	COG2502	aspartate--ammonia ligase
LCF45_08985	COG1051	belongs to the nudix hydrolase family
LCF45_08990	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCF45_09000	COG2814	Major facilitator Superfamily
LCF45_09030	COG0477	Major facilitator Superfamily
LCF45_09035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCF45_09045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LCF45_09050	COG2223	nitrite transmembrane transporter activity
LCF45_09055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LCF45_09070	COG2244	polysaccharide biosynthetic process
LCF45_09075	COG0733	neurotransmitter:sodium symporter activity
LCF45_09085	COG5566	PFAM Mor transcription activator
LCF45_09090	COG2323	membrane
LCF45_09105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LCF45_09115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LCF45_09120	COG0028	Belongs to the TPP enzyme family
LCF45_09135	COG0129	dihydroxy-acid dehydratase activity
LCF45_09140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LCF45_09150	COG2843	Capsule synthesis protein
LCF45_09165	COG2814	Major facilitator Superfamily
LCF45_09170	COG3384	dioxygenase
LCF45_09195	COG4166	transmembrane transport
LCF45_09200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_09210	COG1914	H( )-stimulated, divalent metal cation uptake system
LCF45_09215	COG1054	Belongs to the UPF0176 family
LCF45_09225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LCF45_09230	COG0531	amino acid
LCF45_09265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LCF45_09280	COG4257	antibiotic catabolic process
LCF45_09285	COG2390	Transcriptional regulator
LCF45_09295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LCF45_09300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCF45_09305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LCF45_09320	COG4846	Membrane protein involved in cytochrome C biogenesis
LCF45_09335	COG0583	DNA-binding transcription factor activity
LCF45_09355	COG0006	proline dipeptidase activity
LCF45_09360	COG2132	Multicopper oxidase
LCF45_09370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LCF45_09390	COG1114	Component of the transport system for branched-chain amino acids
LCF45_09400	COG1276	copper resistance
LCF45_09400	COG2372	response to copper ion
LCF45_09405	COG4549	nuclear export factor GLE1
LCF45_09415	COG0697	spore germination
LCF45_09420	COG0583	DNA-binding transcription factor activity
LCF45_09425	COG1959	2 iron, 2 sulfur cluster binding
LCF45_09430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LCF45_09435	COG0778	Nitroreductase
LCF45_09450	COG0628	permease
LCF45_09465	COG1231	oxidoreductase activity
LCF45_09470	COG0523	cobalamin synthesis protein
LCF45_09480	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_09485	COG2030	dehydratase
LCF45_09490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCF45_09505	COG0411	ABC transporter
LCF45_09525	COG0583	DNA-binding transcription factor activity
LCF45_09535	COG1942	4-Oxalocrotonate Tautomerase
LCF45_09550	COG0346	lactoylglutathione lyase activity
LCF45_09560	COG1271	oxidase subunit
LCF45_09565	COG1294	oxidase, subunit
LCF45_09570	COG4988	ABC transporter
LCF45_09575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LCF45_09605	COG1686	Belongs to the peptidase S11 family
LCF45_09620	COG0791	NLP P60 protein
LCF45_09620	COG1388	LysM domain
LCF45_09630	COG1132	(ABC) transporter
LCF45_09635	COG0745	RESPONSE REGULATOR receiver
LCF45_09640	COG5002	protein histidine kinase activity
LCF45_09645	COG0300	oxidoreductase activity
LCF45_09650	COG4122	O-methyltransferase activity
LCF45_09670	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LCF45_09680	COG0460	homoserine dehydrogenase
LCF45_09690	COG0083	homoserine kinase activity
LCF45_09705	COG1316	TRANSCRIPTIONal
LCF45_09730	COG1285	pathogenesis
LCF45_09735	COG1247	-acetyltransferase
LCF45_09755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LCF45_09765	COG1082	Xylose isomerase domain protein TIM barrel
LCF45_09775	COG2814	Major facilitator Superfamily
LCF45_09780	COG1279	arginine transmembrane transporter activity
LCF45_09785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_09795	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCF45_09825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LCF45_09830	COG0577	efflux transmembrane transporter activity
LCF45_09835	COG2002	toxin-antitoxin pair type II binding
LCF45_09840	COG1404	Belongs to the peptidase S8 family
LCF45_09845	COG0640	Transcriptional regulator
LCF45_09895	COG3949	Membrane
LCF45_09900	COG0783	Belongs to the Dps family
LCF45_09915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LCF45_09925	COG1231	oxidoreductase activity
LCF45_09930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_09935	COG4989	oxidoreductase activity
LCF45_09940	COG0523	cobalamin synthesis protein
LCF45_09945	COG0456	acetyltransferase
LCF45_09950	COG0803	Belongs to the bacterial solute-binding protein 9 family
LCF45_09965	COG2814	Major facilitator Superfamily
LCF45_09970	COG1136	(ABC) transporter
LCF45_09975	COG0577	efflux transmembrane transporter activity
LCF45_09980	COG0745	RESPONSE REGULATOR receiver
LCF45_09985	COG2205	protein histidine kinase activity
LCF45_09990	COG1902	pentaerythritol trinitrate reductase activity
LCF45_09995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LCF45_10005	COG4166	transmembrane transport
LCF45_10010	COG0346	lactoylglutathione lyase activity
LCF45_10020	COG0406	alpha-ribazole phosphatase activity
LCF45_10030	COG5337	Spore coat protein CotH
LCF45_10035	COG1051	belongs to the nudix hydrolase family
LCF45_10040	COG0586	Pfam SNARE associated Golgi protein
LCF45_10045	COG2244	polysaccharide biosynthetic process
LCF45_10055	COG0701	Predicted permease
LCF45_10060	COG3689	TIGRFAM TIGR03943 family protein
LCF45_10065	COG1607	acyl-coa hydrolase
LCF45_10075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCF45_10090	COG0702	epimerase
LCF45_10095	COG2839	Protein conserved in bacteria
LCF45_10100	COG1253	flavin adenine dinucleotide binding
LCF45_10115	COG1114	Component of the transport system for branched-chain amino acids
LCF45_10120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCF45_10140	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCF45_10150	COG1876	peptidase activity
LCF45_10165	COG2211	Major facilitator Superfamily
LCF45_10180	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCF45_10190	COG0561	phosphatase activity
LCF45_10195	COG1846	Transcriptional regulator
LCF45_10200	COG2814	Major facilitator Superfamily
LCF45_10210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LCF45_10225	COG1819	glycosyl
LCF45_10230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_10235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_10260	COG0456	acetyltransferase
LCF45_10295	COG4499	WXG100 protein secretion system (Wss), protein YukC
LCF45_10375	COG3874	Sporulation protein YtfJ
LCF45_10400	COG2226	methyltransferase
LCF45_10430	COG0604	alcohol dehydrogenase
LCF45_10435	COG1595	DNA-templated transcription, initiation
LCF45_10455	COG0426	domain, Protein
LCF45_10455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCF45_10465	COG0386	Belongs to the glutathione peroxidase family
LCF45_10470	COG1305	Transglutaminase-like
LCF45_10475	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
LCF45_10480	COG0714	Associated with various cellular activities
LCF45_10485	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LCF45_10490	COG1140	nitrate reductase beta subunit
LCF45_10495	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LCF45_10500	COG2181	nitrate reductase activity
LCF45_10505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LCF45_10510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LCF45_10515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LCF45_10520	COG0303	'Molybdopterin
LCF45_10525	COG0314	molybdopterin synthase activity
LCF45_10535	COG2223	nitrite transmembrane transporter activity
LCF45_10555	COG1648	precorrin-2 dehydrogenase activity
LCF45_10565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LCF45_10565	COG1587	Uroporphyrinogen-III synthase
LCF45_10570	COG2146	nitrite reductase [NAD(P)H] activity
LCF45_10575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LCF45_10580	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
LCF45_10610	COG2359	stage V sporulation protein S
LCF45_10650	COG1418	mRNA catabolic process
LCF45_10655	COG0488	(ABC) transporter
LCF45_10675	COG1413	lyase activity
LCF45_10690	COG2521	methyltransferase
LCF45_10690	COG2136	Putative SAM-dependent methyltransferase
LCF45_10695	COG0018	arginyl-trna synthetase
LCF45_10750	COG0017	Asparaginyl-tRNA synthetase
LCF45_10755	COG0733	neurotransmitter:sodium symporter activity
LCF45_10780	COG2610	gluconate transmembrane transporter activity
LCF45_10790	COG1794	racemase activity, acting on amino acids and derivatives
LCF45_10800	COG0456	acetyltransferase
LCF45_10805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LCF45_10815	COG1131	(ABC) transporter
LCF45_10820	COG4473	ABC transporter
LCF45_10830	COG0546	phosphoglycolate phosphatase activity
LCF45_10845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LCF45_10860	COG0768	penicillin binding
LCF45_10870	COG0204	Acyl-transferase
LCF45_10875	COG1272	protein, Hemolysin III
LCF45_10880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LCF45_10885	COG0805	protein transport
LCF45_10900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LCF45_10905	COG1999	signal sequence binding
LCF45_10910	COG0071	Belongs to the small heat shock protein (HSP20) family
LCF45_10915	COG0367	asparagine synthase
LCF45_10930	COG0860	N-Acetylmuramoyl-L-alanine amidase
LCF45_10935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_10940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LCF45_10960	COG1335	isochorismatase
LCF45_10970	COG0668	transmembrane transport
LCF45_10975	COG2203	Gaf domain
LCF45_10975	COG4585	Histidine kinase
LCF45_10980	COG2197	response regulator
LCF45_10985	COG1737	Transcriptional regulator
LCF45_10990	COG1064	alcohol dehydrogenase
LCF45_11005	COG1070	Carbohydrate kinase
LCF45_11015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LCF45_11035	COG1125	glycine betaine transport
LCF45_11035	COG0517	IMP dehydrogenase activity
LCF45_11040	COG1174	glycine betaine transport
LCF45_11075	COG1253	flavin adenine dinucleotide binding
LCF45_11080	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_11085	COG5506	Protein of unknown function (DUF1694)
LCF45_11100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LCF45_11105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LCF45_11110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LCF45_11115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LCF45_11120	COG0456	acetyltransferase
LCF45_11125	COG3829	transcription factor binding
LCF45_11130	COG1509	lysine 2,3-aminomutase activity
LCF45_11140	COG4479	Belongs to the UPF0346 family
LCF45_11165	COG3064	Membrane
LCF45_11165	COG0515	serine threonine protein kinase
LCF45_11165	COG4991	sh3 domain protein
LCF45_11175	COG0671	phosphoesterase, PA-phosphatase related
LCF45_11180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LCF45_11185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCF45_11235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LCF45_11260	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_11280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCF45_11280	COG4499	WXG100 protein secretion system (Wss), protein YukC
LCF45_11290	COG2814	Major facilitator Superfamily
LCF45_11300	COG0372	Belongs to the citrate synthase family
LCF45_11305	COG2079	MmgE PrpD family protein
LCF45_11310	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LCF45_11315	COG1960	acyl-CoA dehydrogenase activity
LCF45_11320	COG2084	Dehydrogenase
LCF45_11325	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_11330	COG1280	lysine exporter protein (LysE YggA)
LCF45_11335	COG1024	Enoyl-CoA hydratase
LCF45_11350	COG0420	3'-5' exonuclease activity
LCF45_11375	COG2223	nitrite transmembrane transporter activity
LCF45_11380	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_11385	COG1169	isochorismate synthase
LCF45_11390	COG1021	2,3-dihydroxybenzoate-AMP ligase
LCF45_11395	COG1535	isochorismatase
LCF45_11395	COG3433	isochorismatase activity
LCF45_11400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LCF45_11405	COG3251	PFAM MbtH domain protein
LCF45_11410	COG2814	Major facilitator Superfamily
LCF45_11425	COG0776	regulation of translation
LCF45_11435	COG2318	DinB family
LCF45_11440	COG1115	amino acid carrier protein
LCF45_11455	COG2329	Antibiotic biosynthesis monooxygenase
LCF45_11470	COG1187	pseudouridine synthase activity
LCF45_11475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LCF45_11480	COG3655	Transcriptional regulator
LCF45_11490	COG1136	(ABC) transporter
LCF45_11500	COG0596	Alpha beta hydrolase
LCF45_11515	COG0028	Belongs to the TPP enzyme family
LCF45_11525	COG2226	methyltransferase
LCF45_11545	COG1253	flavin adenine dinucleotide binding
LCF45_11585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LCF45_11605	COG1846	Transcriptional regulator
LCF45_11615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCF45_11620	COG1309	transcriptional regulator
LCF45_11650	COG1247	-acetyltransferase
LCF45_11680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LCF45_11690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_11720	COG0583	DNA-binding transcription factor activity
LCF45_11725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LCF45_11740	COG0583	DNA-binding transcription factor activity
LCF45_11745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LCF45_11750	COG2258	MOSC domain
LCF45_11765	COG1132	(ABC) transporter
LCF45_11770	COG1132	(ABC) transporter
LCF45_11785	COG0189	ligase activity
LCF45_11800	COG4974	Belongs to the 'phage' integrase family
LCF45_11810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_11825	COG1396	sequence-specific DNA binding
LCF45_11860	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LCF45_11940	COG2755	lipolytic protein G-D-S-L family
LCF45_11940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LCF45_11950	COG2169	Transcriptional regulator
LCF45_11955	COG0673	inositol 2-dehydrogenase activity
LCF45_11960	COG0673	inositol 2-dehydrogenase activity
LCF45_12020	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LCF45_12025	COG2971	BadF BadG BcrA BcrD
LCF45_12035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LCF45_12085	COG1309	transcriptional regulator
LCF45_12100	COG1136	(ABC) transporter
LCF45_12105	COG0500	methyltransferase
LCF45_12105	COG3615	Tellurite resistance protein tehB
LCF45_12115	COG0693	protein deglycase activity
LCF45_12125	COG0588	phosphoglycerate mutase activity
LCF45_12150	COG2195	Cleaves the N-terminal amino acid of tripeptides
LCF45_12160	COG0110	maltose O-acetyltransferase activity
LCF45_12165	COG1136	(ABC) transporter
LCF45_12190	COG1686	Belongs to the peptidase S11 family
LCF45_12220	COG0768	penicillin binding
LCF45_12225	COG0745	RESPONSE REGULATOR receiver
LCF45_12230	COG2205	protein histidine kinase activity
LCF45_12235	COG1136	(ABC) transporter
LCF45_12240	COG0577	efflux transmembrane transporter activity
LCF45_12250	COG1595	DNA-templated transcription, initiation
LCF45_12260	COG0768	penicillin binding
LCF45_12265	COG0768	penicillin binding
LCF45_12300	COG1252	NADH dehydrogenase
LCF45_12305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCF45_12305	COG0425	Belongs to the sulfur carrier protein TusA family
LCF45_12320	COG0697	spore germination
LCF45_12345	COG3397	chitin binding
LCF45_12350	COG0823	Involved in the tonB-independent uptake of proteins
LCF45_12360	COG1408	metallophosphoesterase
LCF45_12370	COG1131	(ABC) transporter
LCF45_12380	COG1309	transcriptional regulator
LCF45_12390	COG1960	acyl-CoA dehydrogenase activity
LCF45_12395	COG0439	Biotin carboxylase
LCF45_12400	COG0511	ligase activity, forming carbon-carbon bonds
LCF45_12405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LCF45_12410	COG1024	Enoyl-CoA hydratase
LCF45_12415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LCF45_12420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCF45_12485	COG1686	Belongs to the peptidase S11 family
LCF45_12510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LCF45_12535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LCF45_12560	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_12565	COG1733	regulation of RNA biosynthetic process
LCF45_12590	COG1309	transcriptional regulator
LCF45_12620	COG0697	spore germination
LCF45_12625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_12665	COG2323	membrane
LCF45_12680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_12685	COG0697	spore germination
LCF45_12690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LCF45_12695	COG0201	protein transport
LCF45_12705	COG0737	Belongs to the 5'-nucleotidase family
LCF45_12710	COG3227	Zinc metalloprotease (Elastase)
LCF45_12715	COG1523	belongs to the glycosyl hydrolase 13 family
LCF45_12730	COG0076	glutamate decarboxylase activity
LCF45_12735	COG0657	acetylesterase activity
LCF45_12750	COG0577	efflux transmembrane transporter activity
LCF45_12755	COG1136	(ABC) transporter
LCF45_12770	COG5002	protein histidine kinase activity
LCF45_12775	COG0745	RESPONSE REGULATOR receiver
LCF45_12780	COG1011	Hydrolase
LCF45_12805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCF45_12810	COG1183	phosphatidylcholine synthase activity
LCF45_12825	COG1132	(ABC) transporter
LCF45_12830	COG3961	Belongs to the TPP enzyme family
LCF45_12850	COG0322	excinuclease ABC activity
LCF45_12875	COG2318	DinB family
LCF45_12890	COG4667	esterase of the alpha-beta hydrolase superfamily
LCF45_12915	COG3878	Protein conserved in bacteria
LCF45_12940	COG1051	belongs to the nudix hydrolase family
LCF45_12945	COG0592	DNA-directed DNA polymerase activity
LCF45_12950	COG2816	NAD+ diphosphatase activity
LCF45_12960	COG2223	nitrite transmembrane transporter activity
LCF45_12970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LCF45_12980	COG0494	nUDIX hydrolase
LCF45_13000	COG0697	spore germination
LCF45_13005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_13020	COG0584	glycerophosphoryl diester phosphodiesterase
LCF45_13035	COG2814	Major facilitator Superfamily
LCF45_13075	COG0768	penicillin binding
LCF45_13080	COG0671	phosphoesterase, PA-phosphatase related
LCF45_13085	COG0604	alcohol dehydrogenase
LCF45_13090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LCF45_13100	COG2205	protein histidine kinase activity
LCF45_13115	COG1122	ATPase activity
LCF45_13120	COG4720	Psort location CytoplasmicMembrane, score
LCF45_13125	COG1794	racemase activity, acting on amino acids and derivatives
LCF45_13130	COG1819	glycosyl
LCF45_13140	COG0768	penicillin binding
LCF45_13145	COG5002	protein histidine kinase activity
LCF45_13150	COG0561	phosphatase activity
LCF45_13195	COG2124	cytochrome p450
LCF45_13245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LCF45_13255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_13260	COG0460	homoserine dehydrogenase
LCF45_13280	COG0577	efflux transmembrane transporter activity
LCF45_13285	COG1136	(ABC) transporter
LCF45_13295	COG0488	(ABC) transporter
LCF45_13300	COG0667	Aldo Keto reductase
LCF45_13305	COG0583	DNA-binding transcription factor activity
LCF45_13310	COG2205	protein histidine kinase activity
LCF45_13315	COG0745	RESPONSE REGULATOR receiver
LCF45_13325	COG3773	Cell wall hydrolase
LCF45_13330	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LCF45_13340	COG3386	PFAM SMP-30 Gluconolaconase
LCF45_13380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_13395	COG2959	enzyme of heme biosynthesis
LCF45_13420	COG3483	tryptophan 2,3-dioxygenase activity
LCF45_13425	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LCF45_13430	COG3844	kynureninase activity
LCF45_13435	COG1309	transcriptional regulator
LCF45_13450	COG3284	Transcriptional regulator
LCF45_13465	COG1349	DNA-binding transcription factor activity
LCF45_13485	COG1959	2 iron, 2 sulfur cluster binding
LCF45_13500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCF45_13505	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCF45_13510	COG0022	dehydrogenase e1 component
LCF45_13515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LCF45_13535	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_13540	COG0456	acetyltransferase
LCF45_13540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LCF45_13570	COG4176	ABC-type proline glycine betaine transport system permease component
LCF45_13575	COG4175	Glycine betaine
LCF45_13575	COG0517	IMP dehydrogenase activity
LCF45_13600	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LCF45_13605	COG2153	protein acetylation
LCF45_13610	COG3397	chitin binding
LCF45_13620	COG1819	glycosyl
LCF45_13635	COG2205	protein histidine kinase activity
LCF45_13640	COG2315	Protein conserved in bacteria
LCF45_13690	COG3973	AAA domain
LCF45_13700	COG2105	PFAM AIG2 family protein
LCF45_13705	COG0514	ATP-dependent DNA helicase (RecQ)
LCF45_13730	COG4637	Psort location Cytoplasmic, score
LCF45_13740	COG1227	inorganic diphosphatase activity
LCF45_13745	COG3397	chitin binding
LCF45_13750	COG2318	DinB family
LCF45_13770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LCF45_13775	COG1115	amino acid carrier protein
LCF45_13780	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_13785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LCF45_13795	COG3938	Belongs to the proline racemase family
LCF45_13800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCF45_13840	COG0586	Pfam SNARE associated Golgi protein
LCF45_13855	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LCF45_13860	COG4166	transmembrane transport
LCF45_13870	COG4948	Mandelate Racemase Muconate Lactonizing
LCF45_13890	COG0667	Aldo Keto reductase
LCF45_13930	COG2936	dipeptidyl-peptidase activity
LCF45_13940	COG0745	RESPONSE REGULATOR receiver
LCF45_13960	COG1307	EDD domain protein, DegV family
LCF45_13985	COG1335	isochorismatase
LCF45_14000	COG2814	Major facilitator Superfamily
LCF45_14010	COG1664	Polymer-forming cytoskeletal
LCF45_14015	COG0789	Transcriptional regulator
LCF45_14020	COG4533	DNA binding
LCF45_14025	COG2814	Major facilitator Superfamily
LCF45_14025	COG0477	Major facilitator Superfamily
LCF45_14045	COG2261	transglycosylase associated protein
LCF45_14060	COG2226	methyltransferase
LCF45_14095	COG0436	Aminotransferase
LCF45_14100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LCF45_14125	COG1131	(ABC) transporter
LCF45_14130	COG2188	Transcriptional regulator
LCF45_14175	COG0628	permease
LCF45_14225	COG2746	aminoglycoside 3-N-acetyltransferase activity
LCF45_14235	COG0697	spore germination
LCF45_14240	COG2318	DinB family
LCF45_14290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCF45_14300	COG2814	Major facilitator Superfamily
LCF45_14305	COG1368	sulfuric ester hydrolase activity
LCF45_14310	COG0488	(ABC) transporter
LCF45_14315	COG1033	growth of symbiont in host cell
LCF45_14315	COG2409	Drug exporters of the RND superfamily
LCF45_14320	COG1309	transcriptional regulator
LCF45_14325	COG0494	nUDIX hydrolase
LCF45_14340	COG0287	Prephenate dehydrogenase
LCF45_14355	COG1605	Chorismate mutase
LCF45_14355	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LCF45_14400	COG1388	LysM domain
LCF45_14400	COG3584	3D domain protein
LCF45_14410	COG0346	lactoylglutathione lyase activity
LCF45_14420	COG0431	NADPH-dependent FMN reductase
LCF45_14450	COG0579	oxidoreductase
LCF45_14455	COG1879	ABC-type sugar transport system periplasmic component
LCF45_14465	COG1172	Belongs to the binding-protein-dependent transport system permease family
LCF45_14470	COG1129	ABC transporter
LCF45_14475	COG2390	Transcriptional regulator
LCF45_14495	COG2226	methyltransferase
LCF45_14515	COG2329	Antibiotic biosynthesis monooxygenase
LCF45_14545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCF45_14550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LCF45_14555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LCF45_14560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LCF45_14565	COG3239	Fatty acid desaturase
LCF45_14590	COG3842	ATPase activity
LCF45_14615	COG1175	transmembrane transport
LCF45_14620	COG1349	DNA-binding transcription factor activity
LCF45_14630	COG3655	Transcriptional regulator
LCF45_14645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_14650	COG0346	lactoylglutathione lyase activity
LCF45_14680	COG0714	Associated with various cellular activities
LCF45_14700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LCF45_14705	COG0753	catalase activity
LCF45_14715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LCF45_14735	COG0778	Nitroreductase
LCF45_14740	COG1846	Transcriptional regulator
LCF45_14775	COG1725	Transcriptional regulator
LCF45_14805	COG2207	Transcriptional regulator
LCF45_14810	COG0456	acetyltransferase
LCF45_14825	COG0697	spore germination
LCF45_14830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_14835	COG1671	Belongs to the UPF0178 family
LCF45_14855	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LCF45_14855	COG0456	acetyltransferase
LCF45_14880	COG0730	response to heat
LCF45_14890	COG0833	amino acid
LCF45_14900	COG4335	DNA alkylation repair
LCF45_14930	COG0768	penicillin binding
LCF45_14945	COG3104	oligopeptide transport
LCF45_14950	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LCF45_14965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LCF45_14970	COG1984	allophanate hydrolase subunit 2
LCF45_14975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LCF45_14980	COG1414	Transcriptional regulator
LCF45_14995	COG1960	acyl-CoA dehydrogenase activity
LCF45_15020	COG0640	Transcriptional regulator
LCF45_15030	COG3314	Sporulation integral membrane protein YlbJ
LCF45_15050	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LCF45_15055	COG0577	efflux transmembrane transporter activity
LCF45_15060	COG0577	efflux transmembrane transporter activity
LCF45_15065	COG1136	(ABC) transporter
LCF45_15095	COG0574	Belongs to the PEP-utilizing enzyme family
LCF45_15095	COG3848	Pyruvate phosphate dikinase
LCF45_15105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LCF45_15130	COG5002	protein histidine kinase activity
LCF45_15135	COG0745	RESPONSE REGULATOR receiver
LCF45_15145	COG1575	Belongs to the MenA family. Type 1 subfamily
LCF45_15175	COG0798	PFAM Bile acid sodium symporter
LCF45_15180	COG0346	lactoylglutathione lyase activity
LCF45_15185	COG0640	Transcriptional regulator
LCF45_15215	COG1309	transcriptional regulator
LCF45_15220	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_15225	COG1522	sequence-specific DNA binding
LCF45_15245	COG0346	lactoylglutathione lyase activity
LCF45_15275	COG0745	RESPONSE REGULATOR receiver
LCF45_15280	COG3850	Histidine kinase
LCF45_15280	COG5002	protein histidine kinase activity
LCF45_15310	COG1073	alpha beta
LCF45_15320	COG0814	amino acid
LCF45_15325	COG1760	l-serine dehydratase
LCF45_15330	COG1760	l-serine dehydratase
LCF45_15340	COG5002	protein histidine kinase activity
LCF45_15345	COG0745	RESPONSE REGULATOR receiver
LCF45_15355	COG5002	protein histidine kinase activity
LCF45_15370	COG0814	amino acid
LCF45_15375	COG0697	spore germination
LCF45_15400	COG4977	sequence-specific DNA binding
LCF45_15430	COG2197	response regulator
LCF45_15440	COG2814	Major facilitator Superfamily
LCF45_15455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LCF45_15475	COG1476	TRANSCRIPTIONal
LCF45_15485	COG2226	methyltransferase
LCF45_15500	COG1696	Membrane protein involved in D-alanine export
LCF45_15510	COG1690	Belongs to the RtcB family
LCF45_15525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LCF45_15540	COG1136	(ABC) transporter
LCF45_15545	COG0577	efflux transmembrane transporter activity
LCF45_15565	COG3850	Histidine kinase
LCF45_15565	COG5002	protein histidine kinase activity
LCF45_15575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_15590	COG1619	proteins homologs of microcin C7 resistance protein MccF
LCF45_15610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LCF45_15645	COG2814	Major facilitator Superfamily
LCF45_15695	COG2849	repeat protein
LCF45_15700	COG5444	nuclease activity
LCF45_15775	COG0477	Major facilitator Superfamily
LCF45_15790	COG1846	Transcriptional regulator
LCF45_15795	COG2814	Major facilitator Superfamily
LCF45_15815	COG1136	(ABC) transporter
LCF45_15815	COG0577	efflux transmembrane transporter activity
LCF45_15845	COG1329	Transcriptional regulator
LCF45_15855	COG0697	spore germination
LCF45_15860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_15905	COG5002	protein histidine kinase activity
LCF45_15920	COG1136	(ABC) transporter
LCF45_15935	COG1131	(ABC) transporter
LCF45_16065	COG4187	Peptidase family M20/M25/M40
LCF45_16070	COG1414	Transcriptional regulator
LCF45_16075	COG0833	amino acid
LCF45_16085	COG2031	fatty acid transporter
LCF45_16145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LCF45_16150	COG1288	antiporter activity
LCF45_16155	COG2356	endonuclease I
LCF45_16160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LCF45_16165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LCF45_16195	COG1785	Belongs to the alkaline phosphatase family
LCF45_16200	COG0778	Nitroreductase
LCF45_16205	COG1733	regulation of RNA biosynthetic process
LCF45_16220	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_16230	COG1131	(ABC) transporter
LCF45_16260	COG1011	Hydrolase
LCF45_16265	COG2365	Tyrosine phosphatase family
LCF45_16290	COG0346	lactoylglutathione lyase activity
LCF45_16295	COG1940	carbohydrate kinase activity
LCF45_16300	COG0738	Major facilitator superfamily
LCF45_16305	COG0110	maltose O-acetyltransferase activity
LCF45_16320	COG0628	permease
LCF45_16325	COG2261	transglycosylase associated protein
LCF45_16360	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
LCF45_16370	COG1253	flavin adenine dinucleotide binding
LCF45_16375	COG0789	Transcriptional regulator
LCF45_16380	COG0697	spore germination
LCF45_16385	COG1357	PFAM Pentapeptide repeats (8 copies)
LCF45_16390	COG3813	Protein conserved in bacteria
LCF45_16395	COG2706	6-phosphogluconolactonase activity
LCF45_16400	COG1070	Carbohydrate kinase
LCF45_16410	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LCF45_16415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LCF45_16430	COG0814	amino acid
LCF45_16450	COG1393	Belongs to the ArsC family
LCF45_16460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCF45_16475	COG0494	nUDIX hydrolase
LCF45_16490	COG0384	phenazine biosynthesis protein PhzF
LCF45_16500	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_16505	COG2249	NAD(P)H dehydrogenase (quinone) activity
LCF45_16510	COG1733	regulation of RNA biosynthetic process
LCF45_16525	COG1191	sigma factor activity
LCF45_16540	COG1876	peptidase activity
LCF45_16570	COG0741	lytic transglycosylase activity
LCF45_16595	COG5002	protein histidine kinase activity
LCF45_16640	COG0814	amino acid
LCF45_16665	COG1151	hydroxylamine reductase activity
LCF45_16695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LCF45_16705	COG2072	flavoprotein involved in K transport
LCF45_16745	COG0604	alcohol dehydrogenase
LCF45_16750	COG1113	amino acid transport
LCF45_16760	COG2814	Major facilitator Superfamily
LCF45_16770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LCF45_16775	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_16785	COG0534	Mate efflux family protein
LCF45_16790	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_16795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LCF45_16810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LCF45_16815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LCF45_16835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_16840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_16845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_16850	COG3739	integral membrane protein
LCF45_16870	COG0583	DNA-binding transcription factor activity
LCF45_16895	COG1193	negative regulation of DNA recombination
LCF45_16915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LCF45_16920	COG1164	Oligoendopeptidase f
LCF45_16925	COG2957	Belongs to the agmatine deiminase family
LCF45_16945	COG3781	membrane
LCF45_16960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LCF45_16995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LCF45_17000	COG0640	Transcriptional regulator
LCF45_17005	COG0604	alcohol dehydrogenase
LCF45_17010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LCF45_17015	COG0457	Tetratricopeptide repeat
LCF45_17025	COG2808	Putative FMN-binding domain
LCF45_17030	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LCF45_17040	COG0277	FAD linked oxidase domain protein
LCF45_17060	COG1285	pathogenesis
LCF45_17070	COG2514	catechol 2,3-dioxygenase activity
LCF45_17075	COG2720	vancomycin resistance protein
LCF45_17100	COG1278	Cold shock
LCF45_17110	COG0716	FMN binding
LCF45_17120	COG0494	nUDIX hydrolase
LCF45_17140	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_17150	COG0165	Argininosuccinate lyase
LCF45_17165	COG4145	pantothenate transmembrane transporter activity
LCF45_17175	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_17180	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_17190	COG1657	PFAM Prenyltransferase squalene oxidase
LCF45_17195	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LCF45_17200	COG2962	Rard protein
LCF45_17205	COG3326	Membrane
LCF45_17210	COG0531	amino acid
LCF45_17245	COG2226	methyltransferase
LCF45_17250	COG4166	transmembrane transport
LCF45_17255	COG4166	transmembrane transport
LCF45_17260	COG4166	transmembrane transport
LCF45_17265	COG1316	TRANSCRIPTIONal
LCF45_17275	COG1595	DNA-templated transcription, initiation
LCF45_17285	COG1131	(ABC) transporter
LCF45_17305	COG0673	inositol 2-dehydrogenase activity
LCF45_17310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LCF45_17315	COG0187	DNA topoisomerase II activity
LCF45_17320	COG1832	CoA-binding protein
LCF45_17325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCF45_17330	COG0745	RESPONSE REGULATOR receiver
LCF45_17340	COG1328	CTP reductase activity
LCF45_17350	COG4841	protein insertion into membrane
LCF45_17355	COG0824	Thioesterase
LCF45_17380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCF45_17395	COG1132	(ABC) transporter
LCF45_17400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LCF45_17430	COG2211	Major facilitator Superfamily
LCF45_17440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LCF45_17455	COG0183	Belongs to the thiolase family
LCF45_17460	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_17465	COG1268	BioY protein
LCF45_17470	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_17520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_17530	COG5002	protein histidine kinase activity
LCF45_17540	COG0400	carboxylic ester hydrolase activity
LCF45_17545	COG0346	lactoylglutathione lyase activity
LCF45_17550	COG0069	glutamate synthase activity
LCF45_17555	COG1902	pentaerythritol trinitrate reductase activity
LCF45_17565	COG1329	Transcriptional regulator
LCF45_17570	COG0010	Belongs to the arginase family
LCF45_17580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LCF45_17585	COG2986	histidine ammonia-lyase
LCF45_17595	COG2226	methyltransferase
LCF45_17620	COG4846	Membrane protein involved in cytochrome C biogenesis
LCF45_17625	COG0785	Cytochrome C biogenesis protein
LCF45_17635	COG1473	amidohydrolase
LCF45_17640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LCF45_17645	COG1131	(ABC) transporter
LCF45_17655	COG0583	DNA-binding transcription factor activity
LCF45_17665	COG1346	cytolysis
LCF45_17680	COG0730	response to heat
LCF45_17690	COG5632	N-Acetylmuramoyl-L-alanine amidase
LCF45_17690	COG3409	Peptidoglycan-binding domain 1 protein
LCF45_17710	COG1132	(ABC) transporter
LCF45_17715	COG1132	(ABC) transporter
LCF45_17720	COG3763	UPF0154 protein
LCF45_17740	COG3639	organic phosphonate transmembrane transporter activity
LCF45_17750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCF45_17755	COG0737	Belongs to the 5'-nucleotidase family
LCF45_17765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LCF45_17770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LCF45_17785	COG1695	Transcriptional regulator
LCF45_17790	COG1132	(ABC) transporter
LCF45_17825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LCF45_17835	COG1181	Belongs to the D-alanine--D-alanine ligase family
LCF45_17840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LCF45_17845	COG5434	Belongs to the glycosyl hydrolase 28 family
LCF45_17845	COG3420	alginic acid biosynthetic process
LCF45_17870	COG0438	transferase activity, transferring glycosyl groups
LCF45_17880	COG0463	Glycosyl transferase, family 2
LCF45_17880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LCF45_17885	COG0438	transferase activity, transferring glycosyl groups
LCF45_17890	COG0438	transferase activity, transferring glycosyl groups
LCF45_17895	COG1086	Polysaccharide biosynthesis protein
LCF45_17900	COG0489	protein tyrosine kinase activity
LCF45_17905	COG3944	biosynthesis protein
LCF45_17910	COG0174	glutamine synthetase
LCF45_17915	COG0789	Transcriptional regulator
LCF45_17920	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LCF45_17925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LCF45_17930	COG2860	membrane
LCF45_17940	COG0464	growth
LCF45_17960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LCF45_17970	COG3584	3D domain protein
LCF45_17970	COG1388	LysM domain
LCF45_17975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCF45_17975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LCF45_17975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCF45_17980	COG1105	Belongs to the carbohydrate kinase PfkB family
LCF45_17985	COG1349	DNA-binding transcription factor activity
LCF45_17990	COG1979	alcohol dehydrogenase
LCF45_17995	COG2322	membrane
LCF45_18005	COG1113	amino acid transport
LCF45_18015	COG1473	amidohydrolase
LCF45_18020	COG1408	metallophosphoesterase
LCF45_18025	COG2116	formate transmembrane transporter activity
LCF45_18040	COG2217	Heavy metal translocating P-type atpase
LCF45_18045	COG2608	mercury ion transmembrane transporter activity
LCF45_18050	COG1937	Protein conserved in bacteria
LCF45_18080	COG4566	intracellular signal transduction
LCF45_18090	COG2819	hydrolase of the alpha beta superfamily
LCF45_18095	COG1120	ATPase activity
LCF45_18100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_18105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_18110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_18115	COG0708	Exodeoxyribonuclease III
LCF45_18120	COG2169	Transcriptional regulator
LCF45_18125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LCF45_18130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LCF45_18135	COG2706	6-phosphogluconolactonase activity
LCF45_18140	COG2195	Cleaves the N-terminal amino acid of tripeptides
LCF45_18145	COG2364	Membrane
LCF45_18155	COG0346	lactoylglutathione lyase activity
LCF45_18160	COG3300	MHYT domain
LCF45_18160	COG5001	Diguanylate cyclase
LCF45_18200	COG1346	cytolysis
LCF45_18210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LCF45_18215	COG0596	Alpha beta hydrolase
LCF45_18220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LCF45_18230	COG2188	Transcriptional regulator
LCF45_18235	COG2723	6-phospho-beta-galactosidase activity
LCF45_18240	COG0823	Involved in the tonB-independent uptake of proteins
LCF45_18245	COG3773	Cell wall hydrolase
LCF45_18255	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LCF45_18275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LCF45_18280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LCF45_18290	COG4550	Control of competence regulator ComK, YlbF/YmcA
LCF45_18295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LCF45_18300	COG1013	pyruvate-flavodoxin oxidoreductase activity
LCF45_18305	COG0674	pyruvate-flavodoxin oxidoreductase activity
LCF45_18305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LCF45_18315	COG2359	stage V sporulation protein S
LCF45_18320	COG1692	metallophosphoesterase
LCF45_18325	COG1418	mRNA catabolic process
LCF45_18330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LCF45_18335	COG1058	Belongs to the CinA family
LCF45_18335	COG1546	Belongs to the CinA family
LCF45_18340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LCF45_18345	COG1426	Protein conserved in bacteria
LCF45_18360	COG0300	oxidoreductase activity
LCF45_18365	COG0612	Peptidase, M16
LCF45_18370	COG0612	Peptidase, M16
LCF45_18375	COG1079	Belongs to the binding-protein-dependent transport system permease family
LCF45_18380	COG4603	Belongs to the binding-protein-dependent transport system permease family
LCF45_18385	COG3845	ABC transporter
LCF45_18390	COG1744	ABC transporter substrate-binding protein PnrA-like
LCF45_18395	COG2188	Transcriptional regulator
LCF45_18405	COG1674	ftsk spoiiie
LCF45_18415	COG0740	serine-type endopeptidase activity
LCF45_18420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LCF45_18430	COG0527	aspartate kinase activity
LCF45_18435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LCF45_18455	COG3546	catalase activity
LCF45_18515	COG3170	Tfp pilus assembly protein FimV
LCF45_18600	COG0582	viral genome integration into host DNA
LCF45_18645	COG0305	Participates in initiation and elongation during chromosome replication
LCF45_18680	COG1396	sequence-specific DNA binding
LCF45_18695	COG2856	Zn peptidase
LCF45_18710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCF45_18715	COG1873	PFAM PRC-barrel domain
LCF45_18720	COG0612	Peptidase, M16
LCF45_18725	COG0726	polysaccharide deacetylase
LCF45_18730	COG1185	polyribonucleotide nucleotidyltransferase activity
LCF45_18740	COG0196	riboflavin kinase activity
LCF45_18750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LCF45_18755	COG1550	Protein conserved in bacteria
LCF45_18760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LCF45_18765	COG1358	cellular component organization or biogenesis
LCF45_18770	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LCF45_18775	COG0195	Participates in both transcription termination and antitermination
LCF45_18780	COG0779	Required for maturation of 30S ribosomal subunits
LCF45_18790	COG0442	prolyl-tRNA aminoacylation
LCF45_18795	COG0750	zinc metalloprotease
LCF45_18805	COG4589	Belongs to the CDS family
LCF45_18815	COG0233	cytoplasmic translational termination
LCF45_18820	COG0528	UMP kinase activity
LCF45_18825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LCF45_18835	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LCF45_18840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LCF45_18845	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LCF45_18850	COG4974	Belongs to the 'phage' integrase family
LCF45_18855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LCF45_18860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LCF45_18865	COG0758	DNA mediated transformation
LCF45_18875	COG0045	succinate-CoA ligase (ADP-forming) activity
LCF45_18880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LCF45_18895	COG0335	large ribosomal subunit rRNA binding
LCF45_18900	COG0336	Belongs to the RNA methyltransferase TrmD family
LCF45_18905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LCF45_18910	COG1837	Belongs to the UPF0109 family
LCF45_18920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LCF45_18930	COG0552	protein localization to endoplasmic reticulum
LCF45_18935	COG1196	nuclear chromosome segregation
LCF45_18940	COG0571	ribonuclease III activity
LCF45_18945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LCF45_18950	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_18955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LCF45_18960	COG0416	fatty acid biosynthetic process
LCF45_18965	COG1349	DNA-binding transcription factor activity
LCF45_18965	COG2050	protein possibly involved in aromatic compounds catabolism
LCF45_18970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LCF45_18975	COG1461	Dihydroxyacetone kinase
LCF45_18980	COG1302	Protein conserved in bacteria
LCF45_18995	COG1564	THIamine pyrophosphokinase
LCF45_19000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LCF45_19010	COG0515	serine threonine protein kinase
LCF45_19010	COG2815	serine threonine protein kinase
LCF45_19015	COG0631	protein serine/threonine phosphatase activity
LCF45_19020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LCF45_19025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LCF45_19025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCF45_19030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LCF45_19035	COG0242	peptide deformylase activity
LCF45_19040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LCF45_19045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LCF45_19050	COG1758	RNA polymerase activity
LCF45_19065	COG1561	YicC-like family, N-terminal region
LCF45_19070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LCF45_19085	COG0006	proline dipeptidase activity
LCF45_19100	COG3069	C4-dicarboxylate transmembrane transporter activity
LCF45_19110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LCF45_19120	COG0167	dihydroorotate dehydrogenase activity
LCF45_19125	COG0543	2 iron, 2 sulfur cluster binding
LCF45_19130	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LCF45_19140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LCF45_19145	COG0540	Belongs to the ATCase OTCase family
LCF45_19155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LCF45_19160	COG0564	pseudouridine synthase activity
LCF45_19165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LCF45_19175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LCF45_19180	COG3599	regulation of cell shape
LCF45_19185	COG2302	S4 RNA-binding domain
LCF45_19190	COG0762	integral membrane protein
LCF45_19195	COG1799	cell septum assembly
LCF45_19200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LCF45_19210	COG1873	PFAM PRC-barrel domain
LCF45_19215	COG1191	sigma factor activity
LCF45_19220	COG1191	sigma factor activity
LCF45_19230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LCF45_19235	COG0849	cell division
LCF45_19240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LCF45_19255	COG0772	Belongs to the SEDS family
LCF45_19260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LCF45_19265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LCF45_19270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LCF45_19275	COG0768	penicillin binding
LCF45_19280	COG0768	penicillin binding
LCF45_19290	COG0275	rRNA processing
LCF45_19295	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LCF45_19300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LCF45_19305	COG0454	-acetyltransferase
LCF45_19315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LCF45_19320	COG1399	metal-binding, possibly nucleic acid-binding protein
LCF45_19325	COG1323	Belongs to the UPF0348 family
LCF45_19330	COG3480	Lon protease (S16) C-terminal proteolytic domain
LCF45_19335	COG1752	Esterase of the alpha-beta hydrolase superfamily
LCF45_19340	COG3314	Sporulation integral membrane protein YlbJ
LCF45_19350	COG0742	ribosomal rna small subunit methyltransferase
LCF45_19360	COG4471	UPF0298 protein
LCF45_19365	COG3679	Belongs to the UPF0342 family
LCF45_19370	COG0406	alpha-ribazole phosphatase activity
LCF45_19385	COG2340	Cysteine-rich secretory protein family
LCF45_19395	COG3336	cytochrome c oxidase
LCF45_19420	COG0109	protoheme IX farnesyltransferase activity
LCF45_19425	COG1612	heme a metabolic process
LCF45_19435	COG0772	Belongs to the SEDS family
LCF45_19440	COG4838	Belongs to the UPF0358 family
LCF45_19445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LCF45_19450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LCF45_19460	COG4896	Protein conserved in bacteria
LCF45_19475	COG1217	gtp-binding protein TYPA
LCF45_19485	COG0483	inositol monophosphate 1-phosphatase activity
LCF45_19495	COG4493	Belongs to the UPF0637 family
LCF45_19500	COG4476	Belongs to the UPF0223 family
LCF45_19505	COG1982	Orn Lys Arg decarboxylase major
LCF45_19550	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCF45_19555	COG0022	dehydrogenase e1 component
LCF45_19560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LCF45_19575	COG0561	phosphatase activity
LCF45_19580	COG5503	Protein of unknown function (DUF1447)
LCF45_19585	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LCF45_19590	COG0569	domain protein
LCF45_19600	COG1473	amidohydrolase
LCF45_19605	COG2171	N-acyltransferase activity
LCF45_19610	COG0583	DNA-binding transcription factor activity
LCF45_19615	COG0517	IMP dehydrogenase activity
LCF45_19625	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
LCF45_19635	COG4703	Protein of unknown function (DUF1797)
LCF45_19650	COG2200	EAL domain
LCF45_19655	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_19660	COG1408	metallophosphoesterase
LCF45_19705	COG2814	Major facilitator Superfamily
LCF45_19715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LCF45_19725	COG3209	COG3209 Rhs family protein
LCF45_19735	COG2205	protein histidine kinase activity
LCF45_19745	COG0436	Aminotransferase
LCF45_19750	COG1609	Transcriptional regulator
LCF45_19755	COG3833	ABC-type maltose transport systems, permease component
LCF45_19760	COG1175	transmembrane transport
LCF45_19765	COG2182	Extracellular solute-binding protein
LCF45_19775	COG0366	Alpha amylase catalytic
LCF45_19780	COG3842	ATPase activity
LCF45_19820	COG0183	Belongs to the thiolase family
LCF45_19855	COG1695	Transcriptional regulator
LCF45_19860	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_19870	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LCF45_19875	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LCF45_19880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LCF45_19885	COG0436	Aminotransferase
LCF45_19890	COG1850	ribulose-bisphosphate carboxylase activity
LCF45_19895	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
LCF45_19900	COG0235	Class ii aldolase
LCF45_19905	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LCF45_19920	COG2084	Dehydrogenase
LCF45_19930	COG2199	diguanylate cyclase activity
LCF45_19935	COG0778	Nitroreductase
LCF45_19960	COG1263	PTS System
LCF45_19960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LCF45_19960	COG2190	(PTS) system
LCF45_19965	COG3711	transcriptional antiterminator
LCF45_19975	COG2188	Transcriptional regulator
LCF45_19980	COG0363	glucosamine-6-phosphate deaminase activity
LCF45_19985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LCF45_19995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LCF45_20000	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LCF45_20010	COG1547	Domain of unknown function (DUF309)
LCF45_20020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LCF45_20025	COG4086	secreted protein
LCF45_20030	COG0561	phosphatase activity
LCF45_20035	COG0697	spore germination
LCF45_20050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCF45_20090	COG1686	Belongs to the peptidase S11 family
LCF45_20095	COG1725	Transcriptional regulator
LCF45_20100	COG1131	(ABC) transporter
LCF45_20120	COG1846	Transcriptional regulator
LCF45_20135	COG0598	Magnesium transport protein CorA
LCF45_20150	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LCF45_20160	COG4974	Belongs to the 'phage' integrase family
LCF45_20170	COG0735	belongs to the Fur family
LCF45_20175	COG1300	Membrane
LCF45_20195	COG0667	Aldo Keto reductase
LCF45_20200	COG0656	L-ascorbic acid biosynthetic process
LCF45_20205	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LCF45_20205	COG0456	acetyltransferase
LCF45_20215	COG1525	nuclease
LCF45_20215	COG0737	Belongs to the 5'-nucleotidase family
LCF45_20215	COG4085	toxin activity
LCF45_20220	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LCF45_20230	COG0596	Alpha beta hydrolase
LCF45_20235	COG2056	Na+-H+ antiporter family
LCF45_20240	COG1609	Transcriptional regulator
LCF45_20245	COG0456	acetyltransferase
LCF45_20250	COG1073	alpha beta
LCF45_20265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCF45_20265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LCF45_20270	COG0307	riboflavin synthase, alpha
LCF45_20275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LCF45_20275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LCF45_20290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LCF45_20295	COG4106	trans-aconitate 2-methyltransferase activity
LCF45_20300	COG2226	methyltransferase
LCF45_20300	COG1073	alpha beta
LCF45_20305	COG0156	8-amino-7-oxononanoate synthase activity
LCF45_20315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LCF45_20325	COG1757	Na H antiporter
LCF45_20330	COG0737	Belongs to the 5'-nucleotidase family
LCF45_20340	COG1522	sequence-specific DNA binding
LCF45_20375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LCF45_20385	COG0300	oxidoreductase activity
LCF45_20390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCF45_20395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LCF45_20400	COG1760	l-serine dehydratase
LCF45_20405	COG1760	l-serine dehydratase
LCF45_20415	COG1234	tRNA 3'-trailer cleavage
LCF45_20430	COG1285	pathogenesis
LCF45_20445	COG2195	Cleaves the N-terminal amino acid of tripeptides
LCF45_20450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_20465	COG1376	ErfK ybiS ycfS ynhG family protein
LCF45_20470	COG4129	membrane
LCF45_20475	COG1126	abc transporter atp-binding protein
LCF45_20480	COG0765	amino acid transport
LCF45_20485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LCF45_20500	COG2816	NAD+ diphosphatase activity
LCF45_20505	COG2323	membrane
LCF45_20510	COG0772	Belongs to the SEDS family
LCF45_20515	COG0508	dehydrogenase complex catalyzes the overall conversion of
LCF45_20520	COG0022	dehydrogenase e1 component
LCF45_20525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LCF45_20530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LCF45_20535	COG3426	butyrate kinase activity
LCF45_20545	COG0280	phosphate acetyltransferase
LCF45_20550	COG3829	transcription factor binding
LCF45_20550	COG3290	protein histidine kinase activity
LCF45_20560	COG0584	glycerophosphoryl diester phosphodiesterase
LCF45_20565	COG3093	addiction module antidote protein HigA
LCF45_20600	COG0745	RESPONSE REGULATOR receiver
LCF45_20605	COG0750	zinc metalloprotease
LCF45_20610	COG0497	DNA recombination
LCF45_20615	COG1438	arginine binding
LCF45_20620	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LCF45_20625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LCF45_20630	COG0142	geranyltranstransferase activity
LCF45_20635	COG1722	exodeoxyribonuclease VII activity
LCF45_20640	COG1570	exodeoxyribonuclease VII activity
LCF45_20645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LCF45_20650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LCF45_20655	COG1302	Protein conserved in bacteria
LCF45_20660	COG0439	Biotin carboxylase
LCF45_20665	COG0511	ligase activity, forming carbon-carbon bonds
LCF45_20710	COG3854	ATPases associated with a variety of cellular activities
LCF45_20730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LCF45_20735	COG0006	proline dipeptidase activity
LCF45_20740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LCF45_20750	COG3872	metal-dependent enzyme
LCF45_20760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LCF45_20800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCF45_20810	COG1609	Transcriptional regulator
LCF45_20820	COG2076	Multidrug Resistance protein
LCF45_20825	COG2076	Multidrug Resistance protein
LCF45_20865	COG1725	Transcriptional regulator
LCF45_20880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LCF45_20885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LCF45_20890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LCF45_20895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LCF45_20920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LCF45_20945	COG4970	Tfp pilus assembly protein FimT
LCF45_20955	COG1459	type II secretion system
LCF45_20960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LCF45_21015	COG0646	methionine synthase
LCF45_21015	COG1410	methionine synthase
LCF45_21020	COG0646	methionine synthase
LCF45_21020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LCF45_21025	COG0626	cystathionine gamma-synthase activity
LCF45_21030	COG0626	cystathionine gamma-synthase activity
LCF45_21050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCF45_21060	COG1940	carbohydrate kinase activity
LCF45_21065	COG4483	Protein conserved in bacteria
LCF45_21070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LCF45_21075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LCF45_21080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LCF45_21085	COG0704	Plays a role in the regulation of phosphate uptake
LCF45_21095	COG0581	inorganic phosphate transmembrane transporter activity
LCF45_21100	COG0573	inorganic phosphate transmembrane transporter activity
LCF45_21105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LCF45_21110	COG0768	penicillin binding
LCF45_21115	COG0477	Major facilitator Superfamily
LCF45_21120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LCF45_21140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LCF45_21145	COG0735	belongs to the Fur family
LCF45_21150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LCF45_21155	COG1121	(ABC) transporter
LCF45_21160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_21170	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LCF45_21185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LCF45_21190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LCF45_21195	COG2384	SAM-dependent methyltransferase
LCF45_21200	COG2010	Cytochrome c
LCF45_21205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LCF45_21210	COG0358	DNA primase activity
LCF45_21220	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LCF45_21225	COG0517	IMP dehydrogenase activity
LCF45_21230	COG1381	Involved in DNA repair and RecF pathway recombination
LCF45_21240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LCF45_21245	COG0295	cytidine deaminase activity
LCF45_21250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LCF45_21255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LCF45_21260	COG1480	7TM receptor with intracellular HD hydrolase
LCF45_21265	COG1702	phosphate starvation-inducible protein PhoH
LCF45_21280	COG1610	YqeY-like protein
LCF45_21285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LCF45_21290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LCF45_21295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LCF45_21305	COG0484	heat shock protein binding
LCF45_21310	COG0443	Heat shock 70 kDa protein
LCF45_21320	COG1420	regulation of RNA biosynthetic process
LCF45_21325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LCF45_21330	COG1733	regulation of RNA biosynthetic process
LCF45_21335	COG0481	GTPase activity
LCF45_21345	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LCF45_21350	COG0268	Binds directly to 16S ribosomal RNA
LCF45_21355	COG1466	dna polymerase III delta subunit
LCF45_21365	COG0658	competence protein
LCF45_21365	COG2333	competence protein COMEC
LCF45_21370	COG2131	deaminase
LCF45_21375	COG1555	photosystem II stabilization
LCF45_21375	COG1596	polysaccharide export
LCF45_21380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LCF45_21385	COG2226	methyltransferase
LCF45_21390	COG0799	negative regulation of ribosome biogenesis
LCF45_21395	COG1713	HD superfamily hydrolase involved in NAD metabolism
LCF45_21400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LCF45_21405	COG1534	Rna-binding protein
LCF45_21410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LCF45_21415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LCF45_21420	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LCF45_21430	COG0688	phosphatidylethanolamine metabolic process
LCF45_21440	COG1595	DNA-templated transcription, initiation
LCF45_21445	COG2357	RelA SpoT domain protein
LCF45_21455	COG1785	Belongs to the alkaline phosphatase family
LCF45_21465	COG2267	carboxylic ester hydrolase activity
LCF45_21500	COG1404	Belongs to the peptidase S8 family
LCF45_21505	COG3186	Phenylalanine-4-hydroxylase
LCF45_21510	COG2154	pterin-4-alpha-carbinolamine dehydratase
LCF45_21515	COG2514	catechol 2,3-dioxygenase activity
LCF45_21520	COG2259	Doxx family
LCF45_21560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_21570	COG1454	alcohol dehydrogenase
LCF45_21570	COG1012	belongs to the aldehyde dehydrogenase family
LCF45_21575	COG0626	cystathionine gamma-synthase activity
LCF45_21580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LCF45_21585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LCF45_21590	COG2226	methyltransferase
LCF45_21605	COG0768	penicillin binding
LCF45_21610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LCF45_21615	COG0572	uridine kinase
LCF45_21620	COG0826	peptidase U32
LCF45_21625	COG0826	peptidase U32
LCF45_21630	COG4122	O-methyltransferase activity
LCF45_21635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LCF45_21645	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LCF45_21650	COG4472	Bacterial protein of unknown function (DUF965)
LCF45_21655	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LCF45_21665	COG0628	permease
LCF45_21685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LCF45_21695	COG0482	sulfurtransferase activity
LCF45_21700	COG1104	cysteine desulfurase activity
LCF45_21705	COG1959	2 iron, 2 sulfur cluster binding
LCF45_21710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LCF45_21720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LCF45_21725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LCF45_21740	COG1490	D-aminoacyl-tRNA deacylase activity
LCF45_21745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LCF45_21750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LCF45_21755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LCF45_21755	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LCF45_21760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LCF45_21765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCF45_21765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LCF45_21775	COG2244	polysaccharide biosynthetic process
LCF45_21780	COG2323	membrane
LCF45_21790	COG1862	Preprotein translocase
LCF45_21795	COG0343	queuine tRNA-ribosyltransferase activity
LCF45_21800	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LCF45_21810	COG2255	four-way junction helicase activity
LCF45_21815	COG0632	four-way junction helicase activity
LCF45_21820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LCF45_21845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LCF45_21850	COG0157	Belongs to the NadC ModD family
LCF45_21855	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LCF45_21860	COG1104	cysteine desulfurase activity
LCF45_21865	COG1827	regulation of RNA biosynthetic process
LCF45_21870	COG2258	MOSC domain
LCF45_21875	COG0077	Prephenate dehydratase
LCF45_21880	COG0577	efflux transmembrane transporter activity
LCF45_21885	COG0577	efflux transmembrane transporter activity
LCF45_21890	COG1136	(ABC) transporter
LCF45_21895	COG5002	protein histidine kinase activity
LCF45_21900	COG0745	RESPONSE REGULATOR receiver
LCF45_21905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LCF45_21910	COG3290	protein histidine kinase activity
LCF45_21920	COG2868	ribosomal protein
LCF45_21930	COG1530	ribonuclease E activity
LCF45_21935	COG1994	Peptidase M50
LCF45_21940	COG0739	heme binding
LCF45_21945	COG2894	cell division
LCF45_21950	COG0850	regulation of cytokinetic process
LCF45_21965	COG1077	Cell shape determining protein MreB Mrl
LCF45_21970	COG2003	Belongs to the UPF0758 family
LCF45_21975	COG0424	maF-like protein
LCF45_21985	COG0285	dihydrofolate synthase activity
LCF45_22000	COG1388	LysM domain
LCF45_22005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LCF45_22010	COG0113	porphobilinogen synthase activity
LCF45_22015	COG1587	Uroporphyrinogen-III synthase
LCF45_22020	COG0181	hydroxymethylbilane synthase activity
LCF45_22025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LCF45_22030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LCF45_22035	COG1846	Transcriptional regulator
LCF45_22040	COG1764	response to oxidative stress
LCF45_22045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LCF45_22055	COG0470	DNA polymerase III
LCF45_22055	COG1067	ATP-dependent peptidase activity
LCF45_22065	COG0544	peptidyl-prolyl cis-trans isomerase activity
LCF45_22095	COG0622	Phosphoesterase
LCF45_22105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LCF45_22110	COG5401	PFAM Sporulation and spore germination
LCF45_22120	COG0477	Major facilitator Superfamily
LCF45_22125	COG2197	response regulator
LCF45_22130	COG2233	PERMEase
LCF45_22135	COG0402	S-adenosylhomocysteine deaminase activity
LCF45_22140	COG1983	PspC domain protein
LCF45_22145	COG1396	sequence-specific DNA binding
LCF45_22150	COG0697	spore germination
LCF45_22160	COG1959	2 iron, 2 sulfur cluster binding
LCF45_22165	COG1668	transmembrane transport
LCF45_22170	COG4152	abc transporter atp-binding protein
LCF45_22175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LCF45_22180	COG1360	Flagellar Motor Protein
LCF45_22185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LCF45_22190	COG1876	peptidase activity
LCF45_22195	COG0824	Thioesterase
LCF45_22200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LCF45_22205	COG1053	succinate dehydrogenase
LCF45_22210	COG2009	succinate dehydrogenase
LCF45_22215	COG1719	4-vinyl reductase, 4VR
LCF45_22220	COG0322	excinuclease ABC activity
LCF45_22225	COG3118	belongs to the thioredoxin family
LCF45_22230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LCF45_22235	COG2086	electron transfer activity
LCF45_22240	COG1024	Enoyl-CoA hydratase
LCF45_22245	COG1309	transcriptional regulator
LCF45_22250	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_22270	COG2318	DinB family
LCF45_22295	COG1131	(ABC) transporter
LCF45_22300	COG2205	protein histidine kinase activity
LCF45_22305	COG0745	RESPONSE REGULATOR receiver
LCF45_22315	COG4895	conserved protein (DUF2196)
LCF45_22320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LCF45_22325	COG2329	Antibiotic biosynthesis monooxygenase
LCF45_22330	COG4509	Sortase family
LCF45_22335	COG1120	ATPase activity
LCF45_22350	COG5386	Cell surface protein
LCF45_22360	COG5386	Cell surface protein
LCF45_22365	COG1114	Component of the transport system for branched-chain amino acids
LCF45_22375	COG1193	negative regulation of DNA recombination
LCF45_22380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LCF45_22380	COG1796	DNA polymerase
LCF45_22385	COG1286	toxin biosynthetic process
LCF45_22390	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LCF45_22395	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LCF45_22420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LCF45_22425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LCF45_22435	COG1418	mRNA catabolic process
LCF45_22465	COG2814	Major facilitator Superfamily
LCF45_22470	COG1566	PFAM secretion protein HlyD family protein
LCF45_22475	COG1309	transcriptional regulator
LCF45_22480	COG1363	Peptidase, m42
LCF45_22490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LCF45_22505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LCF45_22515	COG1484	DNA-dependent DNA replication
LCF45_22520	COG3611	Membrane attachment protein
LCF45_22525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LCF45_22530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LCF45_22535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCF45_22540	COG0237	dephospho-CoA kinase activity
LCF45_22545	COG1971	Probably functions as a manganese efflux pump
LCF45_22555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCF45_22555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LCF45_22560	COG5002	protein histidine kinase activity
LCF45_22565	COG0745	RESPONSE REGULATOR receiver
LCF45_22580	COG0039	L-malate dehydrogenase activity
LCF45_22585	COG0538	isocitrate dehydrogenase activity
LCF45_22590	COG0372	Belongs to the citrate synthase family
LCF45_22600	COG0628	permease
LCF45_22605	COG3030	protein affecting phage T7 exclusion by the F plasmid
LCF45_22615	COG0205	6-phosphofructokinase activity
LCF45_22625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LCF45_22630	COG1725	Transcriptional regulator
LCF45_22635	COG0281	malic enzyme
LCF45_22640	COG0587	DNA-directed DNA polymerase activity
LCF45_22655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LCF45_22670	COG4109	DRTGG domain
LCF45_22685	COG0006	proline dipeptidase activity
LCF45_22715	COG0662	Cupin 2, conserved barrel domain protein
LCF45_22725	COG1476	TRANSCRIPTIONal
LCF45_22740	COG1028	Short-chain dehydrogenase reductase Sdr
LCF45_22745	COG0589	response to stress
LCF45_22765	COG0165	Argininosuccinate lyase
LCF45_22770	COG0137	argininosuccinate synthase activity
LCF45_22785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_22805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LCF45_22810	COG0827	DNA restriction-modification system
LCF45_22815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LCF45_22820	COG3874	Sporulation protein YtfJ
LCF45_22835	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LCF45_22845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCF45_22860	COG1104	cysteine desulfurase activity
LCF45_22865	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LCF45_22880	COG1309	transcriptional regulator
LCF45_22885	COG1956	GAF domain-containing protein
LCF45_22890	COG0626	cystathionine gamma-synthase activity
LCF45_22895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LCF45_22920	COG1595	DNA-templated transcription, initiation
LCF45_22930	COG0110	maltose O-acetyltransferase activity
LCF45_22935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LCF45_22940	COG0454	-acetyltransferase
LCF45_22945	COG0517	IMP dehydrogenase activity
LCF45_22950	COG0123	including yeast histone deacetylase and acetoin utilization protein
LCF45_22955	COG2267	carboxylic ester hydrolase activity
LCF45_22965	COG0745	RESPONSE REGULATOR receiver
LCF45_22970	COG5002	protein histidine kinase activity
LCF45_22985	COG1970	mechanosensitive ion channel activity
LCF45_23005	COG1609	Transcriptional regulator
LCF45_23015	COG4851	CamS sex pheromone cAM373 precursor
LCF45_23020	COG3118	belongs to the thioredoxin family
LCF45_23030	COG2309	aminopeptidase activity
LCF45_23060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LCF45_23085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCF45_23090	COG4848	Belongs to the UPF0354 family
LCF45_23095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCF45_23100	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LCF45_23105	COG1363	Peptidase, m42
LCF45_23115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCF45_23120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LCF45_23130	COG0510	thiamine kinase activity
LCF45_23135	COG1523	belongs to the glycosyl hydrolase 13 family
LCF45_23145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LCF45_23150	COG1349	DNA-binding transcription factor activity
LCF45_23155	COG1187	pseudouridine synthase activity
LCF45_23160	COG2244	polysaccharide biosynthetic process
LCF45_23165	COG2081	HI0933 family
LCF45_23170	COG2814	Major facilitator Superfamily
LCF45_23180	COG3832	glyoxalase III activity
LCF45_23200	COG1329	Transcriptional regulator
LCF45_23225	COG0314	molybdopterin synthase activity
LCF45_23230	COG1763	Mo-molybdopterin cofactor biosynthetic process
LCF45_23235	COG0303	'Molybdopterin
LCF45_23240	COG0315	cyclic pyranopterin monophosphate synthase activity
LCF45_23245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LCF45_23250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LCF45_23270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LCF45_23280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LCF45_23320	COG0495	leucyl-tRNA aminoacylation
LCF45_23325	COG2814	Major facilitator Superfamily
LCF45_23330	COG0475	glutathione-regulated potassium exporter activity
LCF45_23335	COG0490	domain, Protein
LCF45_23340	COG0582	viral genome integration into host DNA
LCF45_23350	COG1136	(ABC) transporter
LCF45_23365	COG1242	4 iron, 4 sulfur cluster binding
LCF45_23370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LCF45_23375	COG1131	(ABC) transporter
LCF45_23385	COG1794	racemase activity, acting on amino acids and derivatives
LCF45_23400	COG2267	carboxylic ester hydrolase activity
LCF45_23405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LCF45_23410	COG0671	phosphoesterase, PA-phosphatase related
LCF45_23415	COG0438	transferase activity, transferring glycosyl groups
LCF45_23430	COG0746	molybdenum cofactor guanylyltransferase activity
LCF45_23450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LCF45_23455	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LCF45_23495	COG5002	protein histidine kinase activity
LCF45_23500	COG3852	Histidine kinase
LCF45_23505	COG0753	catalase activity
LCF45_23510	COG2267	carboxylic ester hydrolase activity
LCF45_23520	COG1368	sulfuric ester hydrolase activity
LCF45_23530	COG4895	conserved protein (DUF2196)
LCF45_23545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LCF45_23550	COG1116	anion transmembrane transporter activity
LCF45_23555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LCF45_23580	COG0494	nUDIX hydrolase
LCF45_23615	COG2076	Multidrug Resistance protein
LCF45_23620	COG2076	Multidrug Resistance protein
LCF45_23625	COG0789	Transcriptional regulator
LCF45_23630	COG1854	S-ribosylhomocysteine lyase activity
LCF45_23640	COG0288	reversible hydration of carbon dioxide
LCF45_23645	COG1271	oxidase subunit
LCF45_23650	COG1294	oxidase, subunit
LCF45_23670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_23695	COG1842	Phage shock protein A
LCF45_23720	COG3859	Proton-coupled thiamine transporter YuaJ
LCF45_23725	COG5002	protein histidine kinase activity
LCF45_23730	COG0745	RESPONSE REGULATOR receiver
LCF45_23755	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LCF45_23760	COG1597	lipid kinase activity
LCF45_23775	COG1136	(ABC) transporter
LCF45_23790	COG5002	protein histidine kinase activity
LCF45_23800	COG0586	Pfam SNARE associated Golgi protein
LCF45_23815	COG0577	efflux transmembrane transporter activity
LCF45_23820	COG1136	(ABC) transporter
LCF45_23825	COG2207	Transcriptional regulator
LCF45_23825	COG3708	Transcriptional regulator
LCF45_23835	COG1131	(ABC) transporter
LCF45_23840	COG5658	integral membrane protein
LCF45_23845	COG0640	Transcriptional regulator
LCF45_23850	COG0745	RESPONSE REGULATOR receiver
LCF45_23855	COG2205	protein histidine kinase activity
LCF45_23860	COG0577	efflux transmembrane transporter activity
LCF45_23865	COG0577	efflux transmembrane transporter activity
LCF45_23870	COG1136	(ABC) transporter
LCF45_23875	COG0577	efflux transmembrane transporter activity
LCF45_23890	COG2188	Transcriptional regulator
LCF45_23910	COG3964	amidohydrolase
LCF45_23930	COG4948	Mandelate Racemase Muconate Lactonizing
LCF45_23935	COG0318	PFAM AMP-dependent synthetase and ligase
LCF45_23945	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LCF45_23955	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LCF45_23960	COG1169	isochorismate synthase
LCF45_23965	COG1575	Belongs to the MenA family. Type 1 subfamily
LCF45_23970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LCF45_23975	COG1278	Cold shock
LCF45_23985	COG0789	Transcriptional regulator
LCF45_23995	COG0058	SHG alpha-glucan phosphorylase activity
LCF45_24005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LCF45_24010	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LCF45_24015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LCF45_24045	COG1595	DNA-templated transcription, initiation
LCF45_24175	COG1285	pathogenesis
LCF45_24180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LCF45_24190	COG0166	Belongs to the GPI family
LCF45_24195	COG2155	Conserved Protein
LCF45_24200	COG1098	S1 RNA binding domain
LCF45_24205	COG0436	Aminotransferase
LCF45_24210	COG1522	sequence-specific DNA binding
LCF45_24215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LCF45_24220	COG2267	carboxylic ester hydrolase activity
LCF45_24230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LCF45_24250	COG5018	Exonuclease
LCF45_24255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LCF45_24275	COG2050	protein possibly involved in aromatic compounds catabolism
LCF45_24285	COG1268	BioY protein
LCF45_24295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LCF45_24300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LCF45_24310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LCF45_24315	COG3584	3D domain protein
LCF45_24330	COG1252	NADH dehydrogenase
LCF45_24335	COG0492	ferredoxin-NADP+ reductase activity
LCF45_24340	COG3708	Transcriptional regulator
LCF45_24355	COG1683	Conserved Protein
LCF45_24380	COG0316	Belongs to the HesB IscA family
LCF45_24385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LCF45_24390	COG4844	belongs to the
LCF45_24395	COG1252	NADH dehydrogenase
LCF45_24405	COG0390	transport system, permease component
LCF45_24410	COG2824	Alkylphosphonate utilization operon protein PhnA
LCF45_24435	COG4837	Protein of unknown function (DUF1462)
LCF45_24440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LCF45_24450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LCF45_24455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LCF45_24470	COG1136	(ABC) transporter
LCF45_24470	COG0577	efflux transmembrane transporter activity
LCF45_24475	COG2249	NAD(P)H dehydrogenase (quinone) activity
LCF45_24485	COG0647	UMP catabolic process
LCF45_24495	COG2445	Protein of unknown function DUF86
LCF45_24500	COG1494	fructose-1,6-bisphosphatase
LCF45_24515	COG4470	Protein conserved in bacteria
LCF45_24525	COG0789	Transcriptional regulator
LCF45_24530	COG4377	Putative membrane peptidase family (DUF2324)
LCF45_24550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LCF45_24555	COG0739	heme binding
LCF45_24565	COG3377	Domain of unknown function (DUF1805)
LCF45_24570	COG0737	Belongs to the 5'-nucleotidase family
LCF45_24575	COG0719	Fe-S assembly protein
LCF45_24580	COG0822	iron-sulfur transferase activity
LCF45_24585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LCF45_24590	COG0719	Fe-S assembly protein
LCF45_24595	COG0396	ATPase activity
LCF45_24600	COG1464	Belongs to the NlpA lipoprotein family
LCF45_24605	COG1464	Belongs to the NlpA lipoprotein family
LCF45_24610	COG2011	ABC-type metal ion transport system permease component
LCF45_24615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LCF45_24625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LCF45_24630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LCF45_24635	COG0509	glycine decarboxylation via glycine cleavage system
LCF45_24640	COG1393	Belongs to the ArsC family
LCF45_24675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LCF45_24680	COG1960	acyl-CoA dehydrogenase activity
LCF45_24685	COG0183	Belongs to the thiolase family
LCF45_24690	COG1024	Enoyl-CoA hydratase
LCF45_24690	COG1250	3-hydroxyacyl-CoA dehydrogenase
LCF45_24700	COG1686	Belongs to the peptidase S11 family
LCF45_24705	COG0506	proline dehydrogenase activity
LCF45_24715	COG0011	TIGRFAM Protein of
LCF45_24720	COG0840	transmembrane signaling receptor activity
LCF45_24735	COG2814	Major facilitator Superfamily
LCF45_24740	COG0531	amino acid
LCF45_24765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LCF45_24795	COG0586	Pfam SNARE associated Golgi protein
LCF45_24805	COG1376	ErfK ybiS ycfS ynhG family protein
LCF45_24810	COG0745	RESPONSE REGULATOR receiver
LCF45_24815	COG5002	protein histidine kinase activity
LCF45_24825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LCF45_24835	COG0840	transmembrane signaling receptor activity
LCF45_24840	COG0840	transmembrane signaling receptor activity
LCF45_24845	COG2151	metal-sulfur cluster biosynthetic enzyme
LCF45_24850	COG3227	Zinc metalloprotease (Elastase)
LCF45_24855	COG1741	Belongs to the pirin family
LCF45_24870	COG0586	Pfam SNARE associated Golgi protein
LCF45_24875	COG0475	glutathione-regulated potassium exporter activity
LCF45_24880	COG0490	domain, Protein
LCF45_24885	COG1115	amino acid carrier protein
LCF45_24890	COG0783	Belongs to the Dps family
LCF45_24900	COG2318	DinB family
LCF45_24905	COG1611	Belongs to the LOG family
LCF45_24915	COG1528	Iron-storage protein
LCF45_24920	COG2311	Membrane
LCF45_24925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCF45_24930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCF45_24935	COG1115	amino acid carrier protein
LCF45_24940	COG1115	amino acid carrier protein
LCF45_24945	COG2910	NAD(P)H-binding
LCF45_24960	COG0656	L-ascorbic acid biosynthetic process
LCF45_24965	COG2814	Major facilitator Superfamily
LCF45_24970	COG1733	regulation of RNA biosynthetic process
LCF45_24980	COG1252	NADH dehydrogenase
LCF45_25000	COG0840	transmembrane signaling receptor activity
LCF45_25000	COG3290	protein histidine kinase activity
LCF45_25010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LCF45_25030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LCF45_25045	COG4224	UPF0291 protein
LCF45_25050	COG1335	isochorismatase
LCF45_25055	COG1522	sequence-specific DNA binding
LCF45_25065	COG1522	sequence-specific DNA binding
LCF45_25070	COG0288	reversible hydration of carbon dioxide
LCF45_25075	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LCF45_25080	COG2233	PERMEase
LCF45_25105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_25120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LCF45_25125	COG0557	exoribonuclease II activity
LCF45_25130	COG1647	Serine aminopeptidase, S33
LCF45_25135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LCF45_25140	COG1346	cytolysis
LCF45_25155	COG0148	phosphopyruvate hydratase activity
LCF45_25165	COG0149	triose-phosphate isomerase activity
LCF45_25170	COG0126	phosphoglycerate kinase activity
LCF45_25175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LCF45_25190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LCF45_25225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LCF45_25240	COG2323	membrane
LCF45_25250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LCF45_25255	COG1481	regulation of sporulation
LCF45_25260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LCF45_25265	COG1660	Displays ATPase and GTPase activities
LCF45_25270	COG1051	belongs to the nudix hydrolase family
LCF45_25280	COG0492	ferredoxin-NADP+ reductase activity
LCF45_25285	COG0457	Tetratricopeptide repeat
LCF45_25290	COG0110	maltose O-acetyltransferase activity
LCF45_25295	COG0546	phosphoglycolate phosphatase activity
LCF45_25300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LCF45_25305	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LCF45_25310	COG1950	PFAM Membrane protein of
LCF45_25315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LCF45_25335	COG0789	Transcriptional regulator
LCF45_25370	COG0583	DNA-binding transcription factor activity
LCF45_25375	COG0789	Transcriptional regulator
LCF45_25380	COG0655	NAD(P)H dehydrogenase (quinone) activity
LCF45_25385	COG0488	(ABC) transporter
LCF45_25395	COG1132	(ABC) transporter
LCF45_25400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCF45_25405	COG0793	Belongs to the peptidase S41A family
LCF45_25405	COG3409	Peptidoglycan-binding domain 1 protein
LCF45_25410	COG2177	Part of the ABC transporter FtsEX involved in
LCF45_25415	COG2884	Cell division ATP-binding protein ftsE
LCF45_25445	COG1131	(ABC) transporter
LCF45_25480	COG1278	Cold shock
LCF45_25485	COG1040	competence protein
LCF45_25490	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LCF45_25495	COG0791	NLP P60 protein
LCF45_25495	COG1388	LysM domain
LCF45_25500	COG1733	regulation of RNA biosynthetic process
LCF45_25505	COG1307	EDD domain protein, DegV family
LCF45_25510	COG1739	Uncharacterized protein family UPF0029
LCF45_25515	COG1316	TRANSCRIPTIONal
LCF45_25520	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LCF45_25525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LCF45_25530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LCF45_25540	COG3933	PFAM sigma-54 factor interaction domain-containing protein
LCF45_25540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LCF45_25560	COG1486	melibiose metabolic process
LCF45_25565	COG1447	Phosphotransferase system cellobiose-specific component IIA
LCF45_25570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LCF45_25590	COG1447	Phosphotransferase system cellobiose-specific component IIA
LCF45_25600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LCF45_25605	COG1301	dicarboxylic acid transport
LCF45_25620	COG1511	domain protein
LCF45_25625	COG0583	DNA-binding transcription factor activity
LCF45_25630	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LCF45_25640	COG1271	oxidase subunit
LCF45_25645	COG1294	oxidase, subunit
LCF45_25650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LCF45_25655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LCF45_25660	COG1620	l-lactate permease
LCF45_25670	COG2389	metal-binding protein
LCF45_25680	COG1368	sulfuric ester hydrolase activity
LCF45_25690	COG0791	NLP P60 protein
LCF45_25690	COG1388	LysM domain
LCF45_25695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LCF45_25705	COG1215	transferase activity, transferring glycosyl groups
LCF45_25710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LCF45_25715	COG1388	LysM domain
LCF45_25715	COG3584	3D domain protein
LCF45_25740	COG4715	Zinc finger, swim domain protein
LCF45_25745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LCF45_25785	COG0577	efflux transmembrane transporter activity
LCF45_25790	COG1136	(ABC) transporter
LCF45_25825	COG5002	protein histidine kinase activity
LCF45_25825	COG3850	Histidine kinase
LCF45_25830	COG0745	RESPONSE REGULATOR receiver
LCF45_25850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LCF45_25855	COG1134	teichoic acid transport
LCF45_25860	COG1682	transport, permease protein
LCF45_25865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LCF45_25870	COG1215	transferase activity, transferring glycosyl groups
LCF45_25870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LCF45_25880	COG1216	Glycosyl transferase, family 2
LCF45_25880	COG1442	glycosyl transferase family 8
LCF45_25900	COG1609	Transcriptional regulator
LCF45_25910	COG0726	polysaccharide deacetylase
LCF45_25920	COG0739	heme binding
LCF45_25935	COG3279	Response regulator of the LytR AlgR family
LCF45_25940	COG2385	sporulation resulting in formation of a cellular spore
LCF45_25955	COG4836	Membrane
LCF45_25960	COG1007	ATP synthesis coupled electron transport
LCF45_25965	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCF45_25970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LCF45_25975	COG0713	ATP synthesis coupled electron transport
LCF45_25980	COG0839	Belongs to the complex I subunit 6 family
LCF45_25990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LCF45_25995	COG0649	NAD binding
LCF45_26000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCF45_26005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCF45_26010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LCF45_26015	COG5001	Diguanylate cyclase
LCF45_26015	COG3300	MHYT domain
LCF45_26030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LCF45_26035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LCF45_26040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LCF45_26045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LCF45_26050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LCF45_26055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LCF45_26065	COG0356	it plays a direct role in the translocation of protons across the membrane
LCF45_26090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LCF45_26100	COG0698	ribose 5-phosphate isomerase
LCF45_26110	COG2190	(PTS) system
LCF45_26115	COG2259	Doxx family
LCF45_26120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LCF45_26130	COG1971	Probably functions as a manganese efflux pump
LCF45_26135	COG0009	L-threonylcarbamoyladenylate synthase
LCF45_26150	COG2890	protein-(glutamine-N5) methyltransferase activity
LCF45_26155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LCF45_26160	COG1435	thymidine kinase activity
LCF45_26170	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LCF45_26175	COG1494	fructose-1,6-bisphosphatase
LCF45_26195	COG4821	SIS domain
LCF45_26200	COG0504	CTP synthase activity
LCF45_26205	COG3343	RNA polymerase activity
LCF45_26215	COG1960	acyl-CoA dehydrogenase activity
LCF45_26220	COG1960	acyl-CoA dehydrogenase activity
LCF45_26225	COG1250	3-hydroxyacyl-CoA dehydrogenase
LCF45_26230	COG0183	Belongs to the thiolase family
LCF45_26235	COG0247	lactate metabolic process
LCF45_26235	COG2181	nitrate reductase activity
LCF45_26240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LCF45_26245	COG4294	response to UV
LCF45_26250	COG5001	Diguanylate cyclase
LCF45_26250	COG3300	MHYT domain
LCF45_26265	COG3227	Zinc metalloprotease (Elastase)
LCF45_26270	COG2197	response regulator
LCF45_26275	COG4585	Histidine kinase
LCF45_26280	COG0842	Transport permease protein
LCF45_26285	COG1131	(ABC) transporter
LCF45_26290	COG0024	Methionine aminopeptidase
LCF45_26295	COG2234	aminopeptidase activity
LCF45_26310	COG4506	Protein conserved in bacteria
LCF45_26315	COG1619	proteins homologs of microcin C7 resistance protein MccF
LCF45_26330	COG0010	Belongs to the arginase family
LCF45_26335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LCF45_26340	COG2814	Major facilitator Superfamily
LCF45_26345	COG0789	Transcriptional regulator
LCF45_26350	COG0584	glycerophosphoryl diester phosphodiesterase
LCF45_26355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LCF45_26365	COG1994	Peptidase M50
LCF45_26375	COG1078	dGTPase activity
LCF45_26380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LCF45_26385	COG1120	ATPase activity
LCF45_26390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_26395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LCF45_26400	COG4844	belongs to the
LCF45_26415	COG0280	phosphate acetyltransferase
LCF45_26420	COG3253	May function as heme-dependent peroxidase
LCF45_26430	COG3773	Cell wall hydrolase
LCF45_26440	COG2363	Small membrane protein
LCF45_26455	COG2233	PERMEase
LCF45_26460	COG0561	phosphatase activity
LCF45_26465	COG2814	Major facilitator Superfamily
LCF45_26470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LCF45_26475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LCF45_26480	COG1131	(ABC) transporter
LCF45_26485	COG2755	lipolytic protein G-D-S-L family
LCF45_26490	COG1609	Transcriptional regulator
LCF45_26500	COG0460	homoserine dehydrogenase
LCF45_26505	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LCF45_26510	COG2873	o-acetylhomoserine
LCF45_26525	COG2197	response regulator
LCF45_26530	COG4585	Histidine kinase
LCF45_26530	COG2203	Gaf domain
LCF45_26535	COG0351	phosphomethylpyrimidine kinase
LCF45_26540	COG3706	GGDEF domain
LCF45_26545	COG2879	small protein
LCF45_26550	COG1966	Carbon starvation protein
LCF45_26555	COG3279	Response regulator of the LytR AlgR family
LCF45_26560	COG0477	Major facilitator Superfamily
LCF45_26585	COG0840	transmembrane signaling receptor activity
LCF45_26595	COG1607	acyl-coa hydrolase
LCF45_26600	COG1216	Glycosyl transferase, family 2
LCF45_26610	COG1216	Glycosyl transferase, family 2
LCF45_26620	COG4485	Bacterial membrane protein, YfhO
LCF45_26625	COG0463	Glycosyl transferase, family 2
LCF45_26635	COG1309	transcriptional regulator
LCF45_26640	COG0488	(ABC) transporter
LCF45_26645	COG1309	transcriptional regulator
LCF45_26650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LCF45_26655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LCF45_26655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LCF45_26660	COG0628	permease
LCF45_26670	COG1380	Effector of murein hydrolase LrgA
LCF45_26675	COG3279	Response regulator of the LytR AlgR family
LCF45_26680	COG3275	phosphorelay sensor kinase activity
LCF45_26685	COG2814	Major facilitator Superfamily
LCF45_26690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LCF45_26695	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
LCF45_26700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LCF45_26750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LCF45_26755	COG1272	protein, Hemolysin III
LCF45_26780	COG1164	Oligoendopeptidase f
LCF45_26790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LCF45_26800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LCF45_26805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LCF45_26810	COG4853	Protein conserved in bacteria
LCF45_26820	COG5002	protein histidine kinase activity
LCF45_26825	COG0745	RESPONSE REGULATOR receiver
LCF45_26855	COG0305	Participates in initiation and elongation during chromosome replication
LCF45_26860	COG0359	binds to the 23S rRNA
LCF45_26865	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LCF45_26870	COG4241	membrane
LCF45_26880	COG0629	single-stranded DNA binding
LCF45_26885	COG0360	Binds together with S18 to 16S ribosomal RNA
LCF45_26890	COG0012	GTP binding
LCF45_26895	COG4481	Protein conserved in bacteria
LCF45_26900	COG0668	transmembrane transport
LCF45_26910	COG1475	DNA binding
LCF45_26915	COG1192	Involved in chromosome partitioning
LCF45_26920	COG1475	DNA binding
LCF45_26925	COG0357	Ribosomal RNA small subunit methyltransferase G
LCF45_26930	COG0445	tRNA wobble uridine modification
LCF45_26935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LCF45_26940	COG1847	R3H domain protein
LCF45_26945	COG0706	membrane insertase activity
LCF45_26950	COG0594	ribonuclease P activity
LCF45_26955	COG0230	Belongs to the bacterial ribosomal protein bL34 family