locus-tag	class	description
HXZ66_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HXZ66_00010	COG0592	DNA-directed DNA polymerase activity
HXZ66_00015	COG2501	S4 domain
HXZ66_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HXZ66_00030	COG0187	DNA topoisomerase II activity
HXZ66_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HXZ66_00040	COG1966	Carbon starvation protein
HXZ66_00050	COG0003	Pfam Anion-transporting ATPase
HXZ66_00055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXZ66_00080	COG0516	GMP reductase activity
HXZ66_00080	COG0517	IMP dehydrogenase activity
HXZ66_00090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HXZ66_00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HXZ66_00100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HXZ66_00110	COG0601	transmembrane transport
HXZ66_00115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXZ66_00125	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HXZ66_00130	COG1858	cytochrome C peroxidase
HXZ66_00140	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HXZ66_00145	COG1138	Cytochrome C-type biogenesis protein
HXZ66_00165	COG1131	(ABC) transporter
HXZ66_00175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXZ66_00185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXZ66_00190	COG0590	tRNA wobble adenosine to inosine editing
HXZ66_00205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HXZ66_00210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HXZ66_00215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HXZ66_00250	COG3401	FG-GAP repeat protein
HXZ66_00260	COG1982	Orn Lys Arg decarboxylase major
HXZ66_00265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXZ66_00270	COG3870	Protein conserved in bacteria
HXZ66_00275	COG0470	DNA polymerase III
HXZ66_00280	COG1774	PSP1 C-terminal conserved region
HXZ66_00285	COG4467	Involved in initiation control of chromosome replication
HXZ66_00290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HXZ66_00295	COG2827	Endonuclease containing a URI domain
HXZ66_00300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HXZ66_00310	COG2002	toxin-antitoxin pair type II binding
HXZ66_00315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXZ66_00315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXZ66_00320	COG0084	hydrolase, TatD family'
HXZ66_00325	COG3584	3D domain protein
HXZ66_00325	COG3583	domain protein
HXZ66_00330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HXZ66_00335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HXZ66_00345	COG4466	Protein conserved in bacteria
HXZ66_00355	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HXZ66_00360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HXZ66_00365	COG2088	sporulation resulting in formation of a cellular spore
HXZ66_00375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HXZ66_00380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HXZ66_00385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HXZ66_00390	COG0193	aminoacyl-tRNA hydrolase activity
HXZ66_00400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HXZ66_00405	COG2002	toxin-antitoxin pair type II binding
HXZ66_00410	COG2244	polysaccharide biosynthetic process
HXZ66_00415	COG3956	TIGRFAM MazG family protein
HXZ66_00420	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HXZ66_00435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HXZ66_00440	COG1098	S1 RNA binding domain
HXZ66_00445	COG2208	phosphoserine phosphatase activity
HXZ66_00450	COG2304	oxidoreductase activity
HXZ66_00455	COG0515	serine threonine protein kinase
HXZ66_00460	COG2966	Psort location CytoplasmicMembrane, score
HXZ66_00470	COG0037	tRNA processing
HXZ66_00475	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HXZ66_00480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HXZ66_00490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HXZ66_00495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HXZ66_00500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HXZ66_00505	COG0512	Glutamine amidotransferase of anthranilate synthase
HXZ66_00510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HXZ66_00515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HXZ66_00520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HXZ66_00525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HXZ66_00530	COG1396	sequence-specific DNA binding
HXZ66_00535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXZ66_00540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HXZ66_00580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HXZ66_00625	COG1285	pathogenesis
HXZ66_00635	COG3880	PFAM UvrB UvrC protein
HXZ66_00640	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HXZ66_00645	COG0542	response to heat
HXZ66_00650	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HXZ66_00655	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HXZ66_00660	COG4956	integral membrane protein (PIN domain superfamily)
HXZ66_00665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HXZ66_00670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HXZ66_00675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXZ66_00680	COG1045	serine acetyltransferase
HXZ66_00685	COG0215	cysteine-tRNA ligase activity
HXZ66_00695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXZ66_00700	COG3688	RNA-binding protein containing a PIN domain
HXZ66_00710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXZ66_00715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HXZ66_00720	COG0250	Participates in transcription elongation, termination and antitermination
HXZ66_00725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HXZ66_00730	COG0081	regulation of translation
HXZ66_00735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HXZ66_00740	COG0222	ribosome binding
HXZ66_00745	COG2813	Specifically methylates the guanine in position
HXZ66_00750	COG0085	RNA polymerase activity
HXZ66_00755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HXZ66_00760	COG1358	cellular component organization or biogenesis
HXZ66_00765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HXZ66_00770	COG0049	tRNA binding
HXZ66_00775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXZ66_00790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HXZ66_00795	COG0088	Forms part of the polypeptide exit tunnel
HXZ66_00800	COG0089	rRNA binding
HXZ66_00805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HXZ66_00810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HXZ66_00815	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HXZ66_00820	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HXZ66_00825	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HXZ66_00830	COG0255	Belongs to the universal ribosomal protein uL29 family
HXZ66_00840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HXZ66_00845	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HXZ66_00850	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HXZ66_00855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXZ66_00860	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HXZ66_00865	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HXZ66_00870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HXZ66_00875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HXZ66_00880	COG1841	ribosomal large subunit assembly
HXZ66_00890	COG0201	protein transport
HXZ66_00895	COG0563	adenylate kinase activity
HXZ66_00900	COG0024	Methionine aminopeptidase
HXZ66_00910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HXZ66_00915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXZ66_00920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HXZ66_00925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HXZ66_00930	COG0202	RNA polymerase activity
HXZ66_00935	COG0203	ribosomal protein L17
HXZ66_00940	COG1122	ATPase activity
HXZ66_00945	COG1122	ATPase activity
HXZ66_00950	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HXZ66_00955	COG0101	tRNA pseudouridine synthase activity
HXZ66_00960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HXZ66_00965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HXZ66_00995	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_01000	COG0789	Transcriptional regulator
HXZ66_01010	COG4221	oxidoreductase activity
HXZ66_01015	COG0667	Aldo Keto reductase
HXZ66_01030	COG0456	acetyltransferase
HXZ66_01035	COG0456	acetyltransferase
HXZ66_01035	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HXZ66_01080	COG2801	Transposase and inactivated derivatives
HXZ66_01095	COG1136	(ABC) transporter
HXZ66_01100	COG0577	efflux transmembrane transporter activity
HXZ66_01130	COG1131	(ABC) transporter
HXZ66_01145	COG1695	Transcriptional regulator
HXZ66_01160	COG1846	Transcriptional regulator
HXZ66_01165	COG0778	Nitroreductase
HXZ66_01170	COG2259	Doxx family
HXZ66_01175	COG0655	NAD(P)H dehydrogenase (quinone) activity
HXZ66_01180	COG1349	DNA-binding transcription factor activity
HXZ66_01185	COG3395	kinase activity
HXZ66_01190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HXZ66_01195	COG2610	gluconate transmembrane transporter activity
HXZ66_01220	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HXZ66_01230	COG1940	carbohydrate kinase activity
HXZ66_01240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXZ66_01255	COG1904	glucuronate isomerase
HXZ66_01260	COG1312	Catalyzes the dehydration of D-mannonate
HXZ66_01265	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_01270	COG0800	Aldolase
HXZ66_01300	COG1136	(ABC) transporter
HXZ66_01310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXZ66_01320	COG1309	transcriptional regulator
HXZ66_01340	COG2323	membrane
HXZ66_01345	COG0038	chloride channel
HXZ66_01355	COG1482	cell wall glycoprotein biosynthetic process
HXZ66_01360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_01360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_01360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_01365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_01365	COG3711	transcriptional antiterminator
HXZ66_01370	COG2190	(PTS) system
HXZ66_01370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_01370	COG1263	PTS System
HXZ66_01375	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_01390	COG0584	glycerophosphoryl diester phosphodiesterase
HXZ66_01410	COG0860	N-Acetylmuramoyl-L-alanine amidase
HXZ66_01415	COG0489	protein tyrosine kinase activity
HXZ66_01425	COG2194	sulfuric ester hydrolase activity
HXZ66_01435	COG0726	polysaccharide deacetylase
HXZ66_01490	COG1595	DNA-templated transcription, initiation
HXZ66_01495	COG5662	AntiSigma factor
HXZ66_01500	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HXZ66_01505	COG4856	YbbR-like protein
HXZ66_01510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXZ66_01515	COG0246	Mannitol dehydrogenase
HXZ66_01525	COG3711	transcriptional antiterminator
HXZ66_01540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXZ66_01560	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXZ66_01585	COG0745	RESPONSE REGULATOR receiver
HXZ66_01590	COG2205	protein histidine kinase activity
HXZ66_01595	COG1136	(ABC) transporter
HXZ66_01600	COG0577	efflux transmembrane transporter activity
HXZ66_01605	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_01610	COG1309	transcriptional regulator
HXZ66_01615	COG0745	RESPONSE REGULATOR receiver
HXZ66_01620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HXZ66_01625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HXZ66_01630	COG1285	pathogenesis
HXZ66_01635	COG2239	Acts as a magnesium transporter
HXZ66_01650	COG1073	alpha beta
HXZ66_01670	COG0477	Major facilitator Superfamily
HXZ66_01705	COG1279	arginine transmembrane transporter activity
HXZ66_01730	COG0747	negative chemotaxis
HXZ66_01735	COG0601	transmembrane transport
HXZ66_01740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXZ66_01745	COG0444	Belongs to the ABC transporter superfamily
HXZ66_01750	COG1124	(ABC) transporter
HXZ66_01770	COG1193	negative regulation of DNA recombination
HXZ66_01785	COG0702	epimerase
HXZ66_01795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXZ66_01810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXZ66_01815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HXZ66_01820	COG0531	amino acid
HXZ66_01825	COG1959	2 iron, 2 sulfur cluster binding
HXZ66_01840	COG0488	(ABC) transporter
HXZ66_01850	COG1105	Belongs to the carbohydrate kinase PfkB family
HXZ66_01855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_01855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_01855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_01860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_01860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_01860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_01985	COG2318	DinB family
HXZ66_01995	COG0114	fumarate hydratase activity
HXZ66_02010	COG1473	amidohydrolase
HXZ66_02015	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HXZ66_02035	COG0737	Belongs to the 5'-nucleotidase family
HXZ66_02050	COG2814	Major facilitator Superfamily
HXZ66_02055	COG2323	membrane
HXZ66_02065	COG0351	phosphomethylpyrimidine kinase
HXZ66_02090	COG1309	transcriptional regulator
HXZ66_02145	COG4585	Histidine kinase
HXZ66_02150	COG2197	response regulator
HXZ66_02155	COG1131	(ABC) transporter
HXZ66_02160	COG1511	domain protein
HXZ66_02160	COG0842	Transport permease protein
HXZ66_02170	COG2153	protein acetylation
HXZ66_02175	COG4989	oxidoreductase activity
HXZ66_02185	COG5002	protein histidine kinase activity
HXZ66_02190	COG0745	RESPONSE REGULATOR receiver
HXZ66_02230	COG0456	acetyltransferase
HXZ66_02235	COG2207	Transcriptional regulator
HXZ66_02235	COG3708	Transcriptional regulator
HXZ66_02240	COG2207	Transcriptional regulator
HXZ66_02240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_02245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_02250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_02255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_02260	COG2819	hydrolase of the alpha beta superfamily
HXZ66_02265	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_02270	COG1169	isochorismate synthase
HXZ66_02275	COG1021	2,3-dihydroxybenzoate-AMP ligase
HXZ66_02280	COG1535	isochorismatase
HXZ66_02280	COG3433	isochorismatase activity
HXZ66_02285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXZ66_02290	COG3251	PFAM MbtH domain protein
HXZ66_02300	COG3711	transcriptional antiterminator
HXZ66_02300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_02305	COG1447	Phosphotransferase system cellobiose-specific component IIA
HXZ66_02315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HXZ66_02320	COG0840	transmembrane signaling receptor activity
HXZ66_02350	COG0456	acetyltransferase
HXZ66_02355	COG0124	histidyl-tRNA synthetase
HXZ66_02375	COG1396	sequence-specific DNA binding
HXZ66_02390	COG4978	Transcriptional regulator
HXZ66_02390	COG0789	Transcriptional regulator
HXZ66_02410	COG1131	(ABC) transporter
HXZ66_02420	COG0673	inositol 2-dehydrogenase activity
HXZ66_02430	COG0673	inositol 2-dehydrogenase activity
HXZ66_02435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HXZ66_02440	COG1063	alcohol dehydrogenase
HXZ66_02445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXZ66_02455	COG0534	Mate efflux family protein
HXZ66_02460	COG2207	Transcriptional regulator
HXZ66_02460	COG1609	Transcriptional regulator
HXZ66_02480	COG0582	viral genome integration into host DNA
HXZ66_02485	COG2910	NAD(P)H-binding
HXZ66_02490	COG1959	2 iron, 2 sulfur cluster binding
HXZ66_02495	COG1388	LysM domain
HXZ66_02495	COG0791	NLP P60 protein
HXZ66_02505	COG0745	RESPONSE REGULATOR receiver
HXZ66_02510	COG5002	protein histidine kinase activity
HXZ66_02520	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HXZ66_02530	COG2207	Transcriptional regulator
HXZ66_02530	COG0662	Cupin 2, conserved barrel domain protein
HXZ66_02545	COG0346	lactoylglutathione lyase activity
HXZ66_02550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HXZ66_02580	COG3711	transcriptional antiterminator
HXZ66_02580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_02585	COG3711	transcriptional antiterminator
HXZ66_02585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_02590	COG1447	Phosphotransferase system cellobiose-specific component IIA
HXZ66_02595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HXZ66_02600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HXZ66_02610	COG0697	spore germination
HXZ66_02640	COG2188	Transcriptional regulator
HXZ66_02645	COG1120	ATPase activity
HXZ66_02650	COG4152	abc transporter atp-binding protein
HXZ66_02665	COG0488	(ABC) transporter
HXZ66_02670	COG2746	aminoglycoside 3-N-acetyltransferase activity
HXZ66_02675	COG3279	Response regulator of the LytR AlgR family
HXZ66_02695	COG2226	methyltransferase
HXZ66_02700	COG1854	S-ribosylhomocysteine lyase activity
HXZ66_02705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HXZ66_02710	COG0626	cystathionine gamma-synthase activity
HXZ66_02725	COG3546	catalase activity
HXZ66_02740	COG3386	PFAM SMP-30 Gluconolaconase
HXZ66_02755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HXZ66_02760	COG0346	lactoylglutathione lyase activity
HXZ66_02775	COG0693	protein deglycase activity
HXZ66_02785	COG5522	Integral membrane protein (intg_mem_TP0381)
HXZ66_02790	COG0604	alcohol dehydrogenase
HXZ66_02795	COG3546	catalase activity
HXZ66_02815	COG1648	precorrin-2 dehydrogenase activity
HXZ66_02815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXZ66_02825	COG1587	Uroporphyrinogen-III synthase
HXZ66_02825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXZ66_02835	COG0243	molybdopterin cofactor binding
HXZ66_02840	COG2146	nitrite reductase [NAD(P)H] activity
HXZ66_02845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXZ66_02850	COG2223	nitrite transmembrane transporter activity
HXZ66_02860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXZ66_02865	COG3290	protein histidine kinase activity
HXZ66_02870	COG4565	transcriptional regulatory protein
HXZ66_02875	COG0471	metal ion transport
HXZ66_02880	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HXZ66_02880	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HXZ66_02890	COG1053	succinate dehydrogenase
HXZ66_02895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HXZ66_02900	COG2048	Heterodisulfide reductase, subunit B
HXZ66_02915	COG2860	membrane
HXZ66_02930	COG1272	protein, Hemolysin III
HXZ66_02965	COG0562	UDP-galactopyranose mutase
HXZ66_02980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HXZ66_02995	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HXZ66_03005	COG4221	oxidoreductase activity
HXZ66_03030	COG1295	ribonuclease BN
HXZ66_03035	COG4895	conserved protein (DUF2196)
HXZ66_03040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXZ66_03045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXZ66_03055	COG2843	Capsule synthesis protein
HXZ66_03065	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HXZ66_03070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HXZ66_03075	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HXZ66_03080	COG4876	unkown
HXZ66_03085	COG2217	Heavy metal translocating P-type atpase
HXZ66_03100	COG0716	FMN binding
HXZ66_03120	COG0626	cystathionine gamma-synthase activity
HXZ66_03125	COG0626	cystathionine gamma-synthase activity
HXZ66_03130	COG0646	methionine synthase
HXZ66_03130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HXZ66_03135	COG0646	methionine synthase
HXZ66_03135	COG1410	methionine synthase
HXZ66_03140	COG2514	catechol 2,3-dioxygenase activity
HXZ66_03145	COG3711	transcriptional antiterminator
HXZ66_03150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_03150	COG1263	PTS System
HXZ66_03150	COG2190	(PTS) system
HXZ66_03155	COG2723	6-phospho-beta-galactosidase activity
HXZ66_03160	COG2329	Antibiotic biosynthesis monooxygenase
HXZ66_03165	COG1227	inorganic diphosphatase activity
HXZ66_03170	COG0697	spore germination
HXZ66_03175	COG0765	amino acid transport
HXZ66_03180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXZ66_03195	COG0840	transmembrane signaling receptor activity
HXZ66_03200	COG1263	PTS System
HXZ66_03200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_03205	COG1846	Transcriptional regulator
HXZ66_03210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXZ66_03215	COG0745	RESPONSE REGULATOR receiver
HXZ66_03220	COG3850	Histidine kinase
HXZ66_03220	COG5002	protein histidine kinase activity
HXZ66_03225	COG3212	peptidase
HXZ66_03230	COG3212	peptidase
HXZ66_03235	COG4607	ABC-type enterochelin transport system periplasmic component
HXZ66_03240	COG4604	ABC transporter, ATP-binding protein
HXZ66_03245	COG4605	iron ion homeostasis
HXZ66_03250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_03255	COG1968	undecaprenyl-diphosphatase activity
HXZ66_03260	COG0697	spore germination
HXZ66_03270	COG2239	Acts as a magnesium transporter
HXZ66_03275	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HXZ66_03280	COG0640	Transcriptional regulator
HXZ66_03315	COG0477	Major facilitator Superfamily
HXZ66_03320	COG0475	glutathione-regulated potassium exporter activity
HXZ66_03325	COG0490	domain, Protein
HXZ66_03330	COG1309	transcriptional regulator
HXZ66_03335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HXZ66_03340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXZ66_03345	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HXZ66_03350	COG1940	carbohydrate kinase activity
HXZ66_03355	COG2202	Pas domain
HXZ66_03355	COG1366	Belongs to the anti-sigma-factor antagonist family
HXZ66_03365	COG0783	Belongs to the Dps family
HXZ66_03375	COG0534	Mate efflux family protein
HXZ66_03390	COG0659	secondary active sulfate transmembrane transporter activity
HXZ66_03400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HXZ66_03410	COG3639	organic phosphonate transmembrane transporter activity
HXZ66_03415	COG0561	phosphatase activity
HXZ66_03420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXZ66_03425	COG0363	glucosamine-6-phosphate deaminase activity
HXZ66_03455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HXZ66_03460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HXZ66_03465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HXZ66_03470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXZ66_03510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HXZ66_03515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXZ66_03550	COG1510	regulation of RNA biosynthetic process
HXZ66_03555	COG3842	ATPase activity
HXZ66_03565	COG0395	ABC-type sugar transport system, permease component
HXZ66_03575	COG1595	DNA-templated transcription, initiation
HXZ66_03585	COG3829	transcription factor binding
HXZ66_03590	COG1012	belongs to the aldehyde dehydrogenase family
HXZ66_03595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXZ66_03600	COG0506	proline dehydrogenase activity
HXZ66_03605	COG2239	Acts as a magnesium transporter
HXZ66_03610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HXZ66_03615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HXZ66_03625	COG3842	ATPase activity
HXZ66_03635	COG1178	ABC-type Fe3 transport system permease component
HXZ66_03640	COG0705	Rhomboid family
HXZ66_03650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HXZ66_03650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HXZ66_03655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HXZ66_03660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXZ66_03670	COG0864	Transcriptional regulator
HXZ66_03675	COG2337	Toxic component of a toxin-antitoxin (TA) module
HXZ66_03680	COG1366	Belongs to the anti-sigma-factor antagonist family
HXZ66_03685	COG1366	Belongs to the anti-sigma-factor antagonist family
HXZ66_03690	COG2172	sigma factor antagonist activity
HXZ66_03695	COG2208	phosphoserine phosphatase activity
HXZ66_03700	COG1366	Belongs to the anti-sigma-factor antagonist family
HXZ66_03705	COG2172	sigma factor antagonist activity
HXZ66_03710	COG1191	sigma factor activity
HXZ66_03715	COG2208	phosphoserine phosphatase activity
HXZ66_03720	COG2183	response to ionizing radiation
HXZ66_03730	COG3091	SprT-like family
HXZ66_03760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HXZ66_03820	COG1115	amino acid carrier protein
HXZ66_03825	COG5002	protein histidine kinase activity
HXZ66_03835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HXZ66_03840	COG0802	atpase or kinase
HXZ66_03845	COG1214	PFAM Peptidase M22, glycoprotease
HXZ66_03850	COG0456	acetyltransferase
HXZ66_03855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HXZ66_03860	COG0488	(ABC) transporter
HXZ66_03865	COG0315	cyclic pyranopterin monophosphate synthase activity
HXZ66_03870	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HXZ66_03875	COG2814	Major facilitator Superfamily
HXZ66_03885	COG1266	CAAX protease self-immunity
HXZ66_03890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HXZ66_03895	COG0459	protein refolding
HXZ66_03930	COG1695	Transcriptional regulator
HXZ66_03945	COG5609	conserved protein (DUF2294)
HXZ66_03950	COG2223	nitrite transmembrane transporter activity
HXZ66_03975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_03975	COG1263	PTS System
HXZ66_03980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HXZ66_03985	COG1737	Transcriptional regulator
HXZ66_03995	COG2207	Transcriptional regulator
HXZ66_04000	COG1070	Carbohydrate kinase
HXZ66_04005	COG4806	L-rhamnose isomerase
HXZ66_04015	COG1064	alcohol dehydrogenase
HXZ66_04020	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HXZ66_04025	COG1012	belongs to the aldehyde dehydrogenase family
HXZ66_04035	COG1609	Transcriptional regulator
HXZ66_04045	COG1175	transmembrane transport
HXZ66_04055	COG1621	beta-fructofuranosidase activity
HXZ66_04060	COG0562	UDP-galactopyranose mutase
HXZ66_04075	COG1472	Belongs to the glycosyl hydrolase 3 family
HXZ66_04085	COG1216	Glycosyl transferase, family 2
HXZ66_04090	COG1472	Belongs to the glycosyl hydrolase 3 family
HXZ66_04105	COG0747	negative chemotaxis
HXZ66_04120	COG0444	Belongs to the ABC transporter superfamily
HXZ66_04160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_04170	COG1131	(ABC) transporter
HXZ66_04175	COG1609	Transcriptional regulator
HXZ66_04185	COG0189	ligase activity
HXZ66_04195	COG1404	Belongs to the peptidase S8 family
HXZ66_04200	COG2155	Conserved Protein
HXZ66_04220	COG0840	transmembrane signaling receptor activity
HXZ66_04225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HXZ66_04280	COG4716	Myosin-crossreactive antigen
HXZ66_04295	COG0024	Methionine aminopeptidase
HXZ66_04320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXZ66_04325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXZ66_04350	COG0747	negative chemotaxis
HXZ66_04355	COG0601	transmembrane transport
HXZ66_04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXZ66_04365	COG0444	Belongs to the ABC transporter superfamily
HXZ66_04370	COG1124	(ABC) transporter
HXZ66_04375	COG0534	Mate efflux family protein
HXZ66_04385	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_04390	COG1785	Belongs to the alkaline phosphatase family
HXZ66_04395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HXZ66_04400	COG0710	3-dehydroquinate dehydratase activity
HXZ66_04405	COG0840	transmembrane signaling receptor activity
HXZ66_04410	COG4213	ABC transporter substrate-binding protein
HXZ66_04415	COG2169	Transcriptional regulator
HXZ66_04430	COG3275	phosphorelay sensor kinase activity
HXZ66_04435	COG2207	Transcriptional regulator
HXZ66_04435	COG4753	response regulator
HXZ66_04440	COG4209	transmembrane transport
HXZ66_04445	COG0395	ABC-type sugar transport system, permease component
HXZ66_04455	COG1501	Belongs to the glycosyl hydrolase 31 family
HXZ66_04460	COG1472	Belongs to the glycosyl hydrolase 3 family
HXZ66_04470	COG5578	integral membrane protein
HXZ66_04495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXZ66_04500	COG2508	Transcriptional regulator
HXZ66_04505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HXZ66_04510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HXZ66_04515	COG2080	2 iron, 2 sulfur cluster binding
HXZ66_04520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HXZ66_04530	COG0402	S-adenosylhomocysteine deaminase activity
HXZ66_04545	COG2351	hydroxyisourate hydrolase activity
HXZ66_04555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HXZ66_04560	COG0385	Bile acid
HXZ66_04565	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_04570	COG0444	Belongs to the ABC transporter superfamily
HXZ66_04575	COG4608	Belongs to the ABC transporter superfamily
HXZ66_04585	COG0601	transmembrane transport
HXZ66_04590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXZ66_04600	COG0745	RESPONSE REGULATOR receiver
HXZ66_04625	COG4988	ABC transporter
HXZ66_04630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HXZ66_04635	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXZ66_04645	COG3237	CsbD-like
HXZ66_04650	COG0154	amidase activity
HXZ66_04655	COG1131	(ABC) transporter
HXZ66_04680	COG1131	(ABC) transporter
HXZ66_04700	COG0778	Nitroreductase
HXZ66_04705	COG0714	Associated with various cellular activities
HXZ66_04710	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HXZ66_04715	COG1305	Transglutaminase-like
HXZ66_04720	COG0519	Catalyzes the synthesis of GMP from XMP
HXZ66_04720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HXZ66_04735	COG2814	Major facilitator Superfamily
HXZ66_04740	COG0583	DNA-binding transcription factor activity
HXZ66_04745	COG2252	PERMEase
HXZ66_04775	COG1131	(ABC) transporter
HXZ66_04780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HXZ66_04785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HXZ66_04790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HXZ66_04795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HXZ66_04800	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HXZ66_04805	COG0047	phosphoribosylformylglycinamidine synthase activity
HXZ66_04810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HXZ66_04815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HXZ66_04820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HXZ66_04825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HXZ66_04835	COG0151	Belongs to the GarS family
HXZ66_04860	COG0542	response to heat
HXZ66_04875	COG4721	ABC-type cobalt transport system, permease component
HXZ66_04880	COG4172	Belongs to the ABC transporter superfamily
HXZ66_04885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HXZ66_04890	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HXZ66_04910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HXZ66_04915	COG1470	cell adhesion involved in biofilm formation
HXZ66_04920	COG4496	protein, YerC YecD
HXZ66_04930	COG0788	formyltetrahydrofolate deformylase activity
HXZ66_04935	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HXZ66_04940	COG0210	DNA helicase
HXZ66_04945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXZ66_04950	COG4851	CamS sex pheromone cAM373 precursor
HXZ66_04955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HXZ66_04960	COG0154	amidase activity
HXZ66_04965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HXZ66_04995	COG1597	lipid kinase activity
HXZ66_05000	COG0488	(ABC) transporter
HXZ66_05020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXZ66_05025	COG2207	Transcriptional regulator
HXZ66_05040	COG0384	phenazine biosynthesis protein PhzF
HXZ66_05055	COG1078	dGTPase activity
HXZ66_05070	COG1131	(ABC) transporter
HXZ66_05075	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HXZ66_05080	COG2346	COG2346, Truncated hemoglobins
HXZ66_05105	COG2197	response regulator
HXZ66_05110	COG4585	Histidine kinase
HXZ66_05115	COG0842	Transport permease protein
HXZ66_05120	COG1131	(ABC) transporter
HXZ66_05135	COG0028	Belongs to the TPP enzyme family
HXZ66_05140	COG3189	MarR family transcriptional regulator
HXZ66_05145	COG5566	PFAM Mor transcription activator
HXZ66_05155	COG0346	lactoylglutathione lyase activity
HXZ66_05160	COG1621	beta-fructofuranosidase activity
HXZ66_05165	COG3275	phosphorelay sensor kinase activity
HXZ66_05170	COG4753	response regulator
HXZ66_05170	COG2207	Transcriptional regulator
HXZ66_05180	COG1621	beta-fructofuranosidase activity
HXZ66_05200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HXZ66_05205	COG1376	ErfK ybiS ycfS ynhG family protein
HXZ66_05210	COG0655	NAD(P)H dehydrogenase (quinone) activity
HXZ66_05215	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXZ66_05220	COG0583	DNA-binding transcription factor activity
HXZ66_05250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXZ66_05255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HXZ66_05295	COG0110	maltose O-acetyltransferase activity
HXZ66_05300	COG1405	negative regulation of cell septum assembly
HXZ66_05300	COG3012	SEC-C Motif Domain Protein
HXZ66_05305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXZ66_05310	COG1329	Transcriptional regulator
HXZ66_05315	COG1278	Cold shock
HXZ66_05345	COG0747	negative chemotaxis
HXZ66_05350	COG0601	transmembrane transport
HXZ66_05355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXZ66_05360	COG0444	Belongs to the ABC transporter superfamily
HXZ66_05365	COG4608	Belongs to the ABC transporter superfamily
HXZ66_05370	COG1472	Belongs to the glycosyl hydrolase 3 family
HXZ66_05375	COG0523	cobalamin synthesis protein
HXZ66_05380	COG0717	Belongs to the dCTP deaminase family
HXZ66_05385	COG3693	PFAM glycoside hydrolase, family 10
HXZ66_05390	COG0772	Belongs to the SEDS family
HXZ66_05400	COG1595	DNA-templated transcription, initiation
HXZ66_05405	COG0789	Transcriptional regulator
HXZ66_05425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HXZ66_05430	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HXZ66_05435	COG1309	transcriptional regulator
HXZ66_05465	COG3732	PTS system glucitol sorbitol-specific
HXZ66_05480	COG0662	Cupin 2, conserved barrel domain protein
HXZ66_05485	COG3173	Aminoglycoside phosphotransferase
HXZ66_05490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXZ66_05520	COG5444	nuclease activity
HXZ66_05565	COG0840	transmembrane signaling receptor activity
HXZ66_05570	COG0561	phosphatase activity
HXZ66_05575	COG1349	DNA-binding transcription factor activity
HXZ66_05580	COG2851	Citrate transporter
HXZ66_05610	COG2124	cytochrome p450
HXZ66_05630	COG0071	Belongs to the small heat shock protein (HSP20) family
HXZ66_05645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HXZ66_05650	COG0720	synthase
HXZ66_05660	COG1940	carbohydrate kinase activity
HXZ66_05670	COG2723	6-phospho-beta-galactosidase activity
HXZ66_05675	COG1309	transcriptional regulator
HXZ66_05680	COG2409	Drug exporters of the RND superfamily
HXZ66_05690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HXZ66_05695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HXZ66_05705	COG2723	6-phospho-beta-galactosidase activity
HXZ66_05710	COG3711	transcriptional antiterminator
HXZ66_05710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_05715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HXZ66_05725	COG0697	spore germination
HXZ66_05735	COG1940	carbohydrate kinase activity
HXZ66_05740	COG2723	6-phospho-beta-galactosidase activity
HXZ66_05770	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_05775	COG0366	Alpha amylase catalytic
HXZ66_05780	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HXZ66_05790	COG1492	cobalamin metabolic process
HXZ66_05800	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HXZ66_05805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_05810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_05815	COG1120	ATPase activity
HXZ66_05820	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HXZ66_05830	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HXZ66_05835	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HXZ66_05840	COG0406	alpha-ribazole phosphatase activity
HXZ66_05855	COG0596	Alpha beta hydrolase
HXZ66_05865	COG3835	regulator
HXZ66_05870	COG2610	gluconate transmembrane transporter activity
HXZ66_05875	COG1929	Belongs to the glycerate kinase type-1 family
HXZ66_05880	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HXZ66_05890	COG0352	thiamine-phosphate diphosphorylase activity
HXZ66_05895	COG0351	phosphomethylpyrimidine kinase
HXZ66_05900	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HXZ66_05905	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HXZ66_05910	COG0514	ATP-dependent DNA helicase (RecQ)
HXZ66_05915	COG0400	carboxylic ester hydrolase activity
HXZ66_05920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HXZ66_05930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXZ66_05935	COG0513	Belongs to the DEAD box helicase family
HXZ66_05940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HXZ66_05955	COG0488	(ABC) transporter
HXZ66_05980	COG0628	permease
HXZ66_05985	COG1597	lipid kinase activity
HXZ66_06005	COG4335	DNA alkylation repair
HXZ66_06010	COG0288	reversible hydration of carbon dioxide
HXZ66_06015	COG1077	Cell shape determining protein MreB Mrl
HXZ66_06020	COG1960	acyl-CoA dehydrogenase activity
HXZ66_06025	COG2258	MOSC domain
HXZ66_06045	COG0534	Mate efflux family protein
HXZ66_06050	COG1994	Peptidase M50
HXZ66_06055	COG1012	belongs to the aldehyde dehydrogenase family
HXZ66_06070	COG0415	Belongs to the DNA photolyase family
HXZ66_06085	COG1254	Belongs to the acylphosphatase family
HXZ66_06105	COG0798	PFAM Bile acid sodium symporter
HXZ66_06150	COG0477	Major facilitator Superfamily
HXZ66_06160	COG0534	Mate efflux family protein
HXZ66_06175	COG1619	proteins homologs of microcin C7 resistance protein MccF
HXZ66_06180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HXZ66_06190	COG0535	radical SAM domain protein
HXZ66_06200	COG0588	phosphoglycerate mutase activity
HXZ66_06215	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HXZ66_06220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXZ66_06230	COG2318	DinB family
HXZ66_06285	COG1396	sequence-specific DNA binding
HXZ66_06290	COG1819	glycosyl
HXZ66_06300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HXZ66_06305	COG0583	DNA-binding transcription factor activity
HXZ66_06315	COG1764	response to oxidative stress
HXZ66_06325	COG0745	RESPONSE REGULATOR receiver
HXZ66_06350	COG0789	Transcriptional regulator
HXZ66_06365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXZ66_06370	COG2814	Major facilitator Superfamily
HXZ66_06375	COG4753	response regulator
HXZ66_06375	COG2207	Transcriptional regulator
HXZ66_06380	COG2972	Histidine kinase
HXZ66_06395	COG2723	6-phospho-beta-galactosidase activity
HXZ66_06410	COG1132	(ABC) transporter
HXZ66_06435	COG0351	phosphomethylpyrimidine kinase
HXZ66_06435	COG0352	thiamine-phosphate diphosphorylase activity
HXZ66_06450	COG2226	methyltransferase
HXZ66_06460	COG1476	TRANSCRIPTIONal
HXZ66_06485	COG0640	Transcriptional regulator
HXZ66_06490	COG0535	radical SAM domain protein
HXZ66_06500	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HXZ66_06505	COG1914	H( )-stimulated, divalent metal cation uptake system
HXZ66_06520	COG1301	dicarboxylic acid transport
HXZ66_06530	COG1966	Carbon starvation protein
HXZ66_06550	COG1176	ABC-type spermidine putrescine transport system, permease component I
HXZ66_06560	COG3842	ATPase activity
HXZ66_06565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HXZ66_06580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_06585	COG2357	RelA SpoT domain protein
HXZ66_06590	COG0745	RESPONSE REGULATOR receiver
HXZ66_06595	COG3850	Histidine kinase
HXZ66_06595	COG5002	protein histidine kinase activity
HXZ66_06600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXZ66_06605	COG2116	formate transmembrane transporter activity
HXZ66_06620	COG2182	Extracellular solute-binding protein
HXZ66_06625	COG1175	transmembrane transport
HXZ66_06630	COG3833	ABC-type maltose transport systems, permease component
HXZ66_06635	COG1874	Beta-galactosidase
HXZ66_06650	COG0366	Alpha amylase catalytic
HXZ66_06655	COG2188	Transcriptional regulator
HXZ66_06675	COG1090	epimerase
HXZ66_06680	COG2137	regulation of response to DNA damage stimulus
HXZ66_06685	COG1620	l-lactate permease
HXZ66_06715	COG1988	membrane-bound metal-dependent
HXZ66_06725	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_06735	COG2059	Chromate
HXZ66_06740	COG2059	Chromate
HXZ66_06750	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_06765	COG3557	Belongs to the UPF0374 family
HXZ66_06770	COG1132	(ABC) transporter
HXZ66_06775	COG4129	membrane
HXZ66_06785	COG2223	nitrite transmembrane transporter activity
HXZ66_06795	COG2204	response regulator
HXZ66_06800	COG0067	glutamate synthase
HXZ66_06800	COG0069	glutamate synthase activity
HXZ66_06800	COG0070	glutamate synthase
HXZ66_06805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXZ66_06815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HXZ66_06820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXZ66_06825	COG3870	Protein conserved in bacteria
HXZ66_06830	COG0735	belongs to the Fur family
HXZ66_07000	COG4824	toxin secretion phage lysis holin
HXZ66_07010	COG2207	Transcriptional regulator
HXZ66_07010	COG3708	Transcriptional regulator
HXZ66_07075	COG2226	methyltransferase
HXZ66_07080	COG1937	Protein conserved in bacteria
HXZ66_07085	COG2210	Belongs to the sulfur carrier protein TusA family
HXZ66_07090	COG1054	Belongs to the UPF0176 family
HXZ66_07095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXZ66_07100	COG0425	Belongs to the sulfur carrier protein TusA family
HXZ66_07100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXZ66_07105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXZ66_07105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXZ66_07110	COG0425	Belongs to the sulfur carrier protein TusA family
HXZ66_07125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HXZ66_07130	COG1683	Conserved Protein
HXZ66_07135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXZ66_07145	COG2340	Cysteine-rich secretory protein family
HXZ66_07150	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_07160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HXZ66_07195	COG5646	InterPro IPR014922
HXZ66_07200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXZ66_07210	COG2766	serine protein kinase
HXZ66_07220	COG2718	Belongs to the UPF0229 family
HXZ66_07235	COG0393	Putative heavy-metal-binding
HXZ66_07245	COG1489	DNA binding
HXZ66_07250	COG3546	catalase activity
HXZ66_07255	COG5002	protein histidine kinase activity
HXZ66_07265	COG3192	ethanolamine utilization protein
HXZ66_07275	COG1744	ABC transporter substrate-binding protein PnrA-like
HXZ66_07280	COG3845	ABC transporter
HXZ66_07285	COG4603	Belongs to the binding-protein-dependent transport system permease family
HXZ66_07290	COG1079	Belongs to the binding-protein-dependent transport system permease family
HXZ66_07300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXZ66_07300	COG3153	acetyltransferase
HXZ66_07310	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HXZ66_07315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HXZ66_07320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HXZ66_07325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HXZ66_07330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXZ66_07340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXZ66_07345	COG1609	Transcriptional regulator
HXZ66_07365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_07370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_07375	COG2207	Transcriptional regulator
HXZ66_07375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_07380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_07385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_07390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_07395	COG1120	ATPase activity
HXZ66_07400	COG2207	Transcriptional regulator
HXZ66_07405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_07410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_07415	COG0778	Nitroreductase
HXZ66_07435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HXZ66_07445	COG0066	3-isopropylmalate dehydratase activity
HXZ66_07450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HXZ66_07455	COG0473	3-isopropylmalate dehydrogenase activity
HXZ66_07460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXZ66_07465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HXZ66_07470	COG0440	acetolactate synthase activity
HXZ66_07475	COG0028	Belongs to the TPP enzyme family
HXZ66_07480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HXZ66_07485	COG2719	SpoVR family
HXZ66_07490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HXZ66_07510	COG0667	Aldo Keto reductase
HXZ66_07520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HXZ66_07525	COG3584	3D domain protein
HXZ66_07525	COG3583	domain protein
HXZ66_07530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXZ66_07535	COG0024	Methionine aminopeptidase
HXZ66_07545	COG1366	Belongs to the anti-sigma-factor antagonist family
HXZ66_07550	COG2340	Cysteine-rich secretory protein family
HXZ66_07555	COG1533	DNA photolyase activity
HXZ66_07570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HXZ66_07575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXZ66_07575	COG1522	sequence-specific DNA binding
HXZ66_07580	COG2313	pseudouridylate synthase activity
HXZ66_07585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_07585	COG1263	PTS System
HXZ66_07595	COG1131	(ABC) transporter
HXZ66_07600	COG1725	Transcriptional regulator
HXZ66_07610	COG1294	oxidase, subunit
HXZ66_07615	COG1271	oxidase subunit
HXZ66_07630	COG1827	regulation of RNA biosynthetic process
HXZ66_07635	COG1104	cysteine desulfurase activity
HXZ66_07640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HXZ66_07645	COG0157	Belongs to the NadC ModD family
HXZ66_07650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HXZ66_07660	COG3842	ATPase activity
HXZ66_07665	COG2508	Transcriptional regulator
HXZ66_07670	COG4399	Belongs to the UPF0754 family
HXZ66_07675	COG3679	Belongs to the UPF0342 family
HXZ66_07680	COG0561	phosphatase activity
HXZ66_07695	COG0745	RESPONSE REGULATOR receiver
HXZ66_07705	COG1136	(ABC) transporter
HXZ66_07710	COG0577	efflux transmembrane transporter activity
HXZ66_07730	COG4152	abc transporter atp-binding protein
HXZ66_07735	COG1668	transmembrane transport
HXZ66_07745	COG0420	3'-5' exonuclease activity
HXZ66_07750	COG4717	serine-type aminopeptidase activity
HXZ66_07755	COG0745	RESPONSE REGULATOR receiver
HXZ66_07760	COG2205	protein histidine kinase activity
HXZ66_07760	COG2770	Histidine kinase
HXZ66_07765	COG3481	metal-dependent phosphohydrolase, HD sub domain
HXZ66_07780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXZ66_07810	COG1846	Transcriptional regulator
HXZ66_07820	COG0537	adenosine 5'-monophosphoramidase activity
HXZ66_07825	COG1131	(ABC) transporter
HXZ66_07850	COG1473	amidohydrolase
HXZ66_07855	COG0785	Cytochrome C biogenesis protein
HXZ66_07860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXZ66_07865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HXZ66_07870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HXZ66_07875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HXZ66_07885	COG5002	protein histidine kinase activity
HXZ66_07900	COG4492	Belongs to the UPF0735 family
HXZ66_07905	COG0077	Prephenate dehydratase
HXZ66_07910	COG1388	LysM domain
HXZ66_07920	COG0217	transcriptional regulatory protein
HXZ66_07930	COG0632	four-way junction helicase activity
HXZ66_07950	COG0343	queuine tRNA-ribosyltransferase activity
HXZ66_07955	COG1862	Preprotein translocase
HXZ66_07965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HXZ66_07970	COG2323	membrane
HXZ66_07975	COG2244	polysaccharide biosynthetic process
HXZ66_07990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXZ66_07990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXZ66_07995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXZ66_07995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXZ66_08000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HXZ66_08005	COG5416	Lipopolysaccharide assembly protein A domain
HXZ66_08010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HXZ66_08010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HXZ66_08015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HXZ66_08020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HXZ66_08025	COG1490	D-aminoacyl-tRNA deacylase activity
HXZ66_08035	COG0124	histidyl-tRNA synthetase
HXZ66_08040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HXZ66_08050	COG0247	lactate metabolic process
HXZ66_08055	COG1139	Iron-sulfur cluster binding protein
HXZ66_08060	COG1556	Lactate utilization protein
HXZ66_08070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HXZ66_08075	COG2364	Membrane
HXZ66_08080	COG1959	2 iron, 2 sulfur cluster binding
HXZ66_08085	COG1104	cysteine desulfurase activity
HXZ66_08090	COG0482	sulfurtransferase activity
HXZ66_08100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HXZ66_08105	COG3881	PFAM PRC-barrel domain
HXZ66_08120	COG0628	permease
HXZ66_08125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXZ66_08130	COG4472	Bacterial protein of unknown function (DUF965)
HXZ66_08140	COG3906	Belongs to the UPF0473 family
HXZ66_08150	COG4122	O-methyltransferase activity
HXZ66_08155	COG0826	peptidase U32
HXZ66_08160	COG0826	peptidase U32
HXZ66_08165	COG0572	uridine kinase
HXZ66_08170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HXZ66_08185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HXZ66_08205	COG2022	thiamine diphosphate biosynthetic process
HXZ66_08215	COG0352	thiamine-phosphate diphosphorylase activity
HXZ66_08225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HXZ66_08230	COG4946	Tricorn protease homolog
HXZ66_08230	COG1506	peptidase
HXZ66_08230	COG0823	Involved in the tonB-independent uptake of proteins
HXZ66_08235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXZ66_08245	COG0803	Belongs to the bacterial solute-binding protein 9 family
HXZ66_08255	COG1396	sequence-specific DNA binding
HXZ66_08260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HXZ66_08265	COG1733	regulation of RNA biosynthetic process
HXZ66_08270	COG1366	Belongs to the anti-sigma-factor antagonist family
HXZ66_08275	COG1587	Uroporphyrinogen-III synthase
HXZ66_08275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXZ66_08285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXZ66_08290	COG0529	Catalyzes the synthesis of activated sulfate
HXZ66_08295	COG2046	Belongs to the sulfate adenylyltransferase family
HXZ66_08305	COG0306	phosphate transporter
HXZ66_08310	COG0656	L-ascorbic acid biosynthetic process
HXZ66_08320	COG0697	spore germination
HXZ66_08325	COG0095	Lipoate-protein ligase
HXZ66_08340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXZ66_08345	COG0450	alkyl hydroperoxide reductase
HXZ66_08350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HXZ66_08350	COG0617	tRNA 3'-terminal CCA addition
HXZ66_08350	COG3620	sequence-specific DNA binding
HXZ66_08355	COG1183	phosphatidylcholine synthase activity
HXZ66_08360	COG0688	phosphatidylethanolamine metabolic process
HXZ66_08365	COG1320	monovalent cation:proton antiporter activity
HXZ66_08370	COG2212	antiporter activity
HXZ66_08375	COG1863	multisubunit Na H antiporter MnhE subunit
HXZ66_08380	COG0651	ATP synthesis coupled electron transport
HXZ66_08385	COG1006	Multisubunit Na H antiporter MnhC subunit
HXZ66_08390	COG2111	Na H antiporter
HXZ66_08395	COG2111	Na H antiporter
HXZ66_08395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HXZ66_08410	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HXZ66_08415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HXZ66_08425	COG1534	Rna-binding protein
HXZ66_08430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HXZ66_08435	COG1713	HD superfamily hydrolase involved in NAD metabolism
HXZ66_08440	COG0799	negative regulation of ribosome biogenesis
HXZ66_08445	COG2226	methyltransferase
HXZ66_08450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXZ66_08455	COG1555	photosystem II stabilization
HXZ66_08455	COG3568	Endonuclease Exonuclease Phosphatase
HXZ66_08460	COG2131	deaminase
HXZ66_08465	COG2333	competence protein COMEC
HXZ66_08465	COG0658	competence protein
HXZ66_08475	COG1466	dna polymerase III delta subunit
HXZ66_08480	COG0268	Binds directly to 16S ribosomal RNA
HXZ66_08490	COG0860	N-Acetylmuramoyl-L-alanine amidase
HXZ66_08500	COG0481	GTPase activity
HXZ66_08505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXZ66_08510	COG1420	regulation of RNA biosynthetic process
HXZ66_08515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HXZ66_08520	COG0443	Heat shock 70 kDa protein
HXZ66_08525	COG0484	heat shock protein binding
HXZ66_08530	COG2264	protein methyltransferase activity
HXZ66_08535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HXZ66_08540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXZ66_08545	COG1283	sodium-dependent phosphate transmembrane transporter activity
HXZ66_08550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HXZ66_08555	COG1610	YqeY-like protein
HXZ66_08565	COG1030	water channel activity
HXZ66_08570	COG4864	UPF0365 protein
HXZ66_08590	COG1702	phosphate starvation-inducible protein PhoH
HXZ66_08595	COG1480	7TM receptor with intracellular HD hydrolase
HXZ66_08605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HXZ66_08615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HXZ66_08625	COG1381	Involved in DNA repair and RecF pathway recombination
HXZ66_08630	COG0752	glycyl-tRNA synthetase alpha subunit
HXZ66_08635	COG0751	glycine-tRNA ligase activity
HXZ66_08640	COG0517	IMP dehydrogenase activity
HXZ66_08645	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HXZ66_08650	COG1671	Belongs to the UPF0178 family
HXZ66_08655	COG0358	DNA primase activity
HXZ66_08660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXZ66_08670	COG0584	glycerophosphoryl diester phosphodiesterase
HXZ66_08680	COG2384	SAM-dependent methyltransferase
HXZ66_08685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HXZ66_08690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HXZ66_08705	COG0513	Belongs to the DEAD box helicase family
HXZ66_08710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HXZ66_08720	COG4191	Histidine kinase
HXZ66_08725	COG1121	(ABC) transporter
HXZ66_08730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXZ66_08735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HXZ66_08745	COG1121	(ABC) transporter
HXZ66_08750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXZ66_08755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXZ66_08760	COG0735	belongs to the Fur family
HXZ66_08770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HXZ66_08775	COG1388	LysM domain
HXZ66_08785	COG4086	secreted protein
HXZ66_08790	COG1030	water channel activity
HXZ66_08800	COG1396	sequence-specific DNA binding
HXZ66_08815	COG0704	Plays a role in the regulation of phosphate uptake
HXZ66_08835	COG4918	Iron-sulphur cluster biosynthesis
HXZ66_08845	COG0477	Major facilitator Superfamily
HXZ66_08855	COG0768	penicillin binding
HXZ66_08875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXZ66_08885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HXZ66_08895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HXZ66_08915	COG0457	Tetratricopeptide repeat
HXZ66_08915	COG0705	Rhomboid family
HXZ66_08940	COG1940	carbohydrate kinase activity
HXZ66_08960	COG0011	TIGRFAM Protein of
HXZ66_08970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXZ66_08990	COG4980	gas vesicle protein
HXZ66_08995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXZ66_09010	COG4537	Required for transformation and DNA binding
HXZ66_09045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXZ66_09050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HXZ66_09055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXZ66_09060	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXZ66_09065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXZ66_09070	COG0095	Lipoate-protein ligase
HXZ66_09075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXZ66_09080	COG1321	iron dependent repressor
HXZ66_09085	COG1752	Esterase of the alpha-beta hydrolase superfamily
HXZ66_09100	COG3872	metal-dependent enzyme
HXZ66_09110	COG0006	proline dipeptidase activity
HXZ66_09115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HXZ66_09120	COG3854	ATPases associated with a variety of cellular activities
HXZ66_09165	COG0511	ligase activity, forming carbon-carbon bonds
HXZ66_09170	COG0439	Biotin carboxylase
HXZ66_09175	COG1302	Protein conserved in bacteria
HXZ66_09180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXZ66_09185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HXZ66_09190	COG1570	exodeoxyribonuclease VII activity
HXZ66_09195	COG1722	exodeoxyribonuclease VII activity
HXZ66_09210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HXZ66_09215	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HXZ66_09220	COG1438	arginine binding
HXZ66_09225	COG0497	DNA recombination
HXZ66_09230	COG0750	zinc metalloprotease
HXZ66_09235	COG0745	RESPONSE REGULATOR receiver
HXZ66_09245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HXZ66_09255	COG3829	transcription factor binding
HXZ66_09255	COG3290	protein histidine kinase activity
HXZ66_09260	COG0280	phosphate acetyltransferase
HXZ66_09275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXZ66_09280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HXZ66_09285	COG0022	dehydrogenase e1 component
HXZ66_09290	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXZ66_09320	COG4129	membrane
HXZ66_09325	COG1376	ErfK ybiS ycfS ynhG family protein
HXZ66_09335	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXZ66_09350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXZ66_09355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXZ66_09365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXZ66_09375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXZ66_09380	COG1728	Protein conserved in bacteria
HXZ66_09390	COG1902	pentaerythritol trinitrate reductase activity
HXZ66_09395	COG0517	IMP dehydrogenase activity
HXZ66_09405	COG2861	carbohydrate metabolic process
HXZ66_09410	COG0789	Transcriptional regulator
HXZ66_09420	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HXZ66_09425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXZ66_09430	COG0300	oxidoreductase activity
HXZ66_09440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HXZ66_09450	COG0367	asparagine synthase
HXZ66_09465	COG0561	phosphatase activity
HXZ66_09475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HXZ66_09480	COG2190	(PTS) system
HXZ66_09485	COG3689	TIGRFAM TIGR03943 family protein
HXZ66_09490	COG0701	Predicted permease
HXZ66_09495	COG1968	undecaprenyl-diphosphatase activity
HXZ66_09500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXZ66_09505	COG0667	Aldo Keto reductase
HXZ66_09510	COG0494	nUDIX hydrolase
HXZ66_09515	COG1379	DNA repair
HXZ66_09520	COG1300	Membrane
HXZ66_09525	COG0735	belongs to the Fur family
HXZ66_09535	COG4974	Belongs to the 'phage' integrase family
HXZ66_09540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HXZ66_09555	COG1686	Belongs to the peptidase S11 family
HXZ66_09565	COG2172	sigma factor antagonist activity
HXZ66_09575	COG0697	spore germination
HXZ66_09580	COG0019	diaminopimelate decarboxylase activity
HXZ66_09585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXZ66_09590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXZ66_09590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXZ66_09595	COG0307	riboflavin synthase, alpha
HXZ66_09600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXZ66_09600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXZ66_09605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HXZ66_09610	COG0456	acetyltransferase
HXZ66_09620	COG1547	Domain of unknown function (DUF309)
HXZ66_09625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HXZ66_09630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HXZ66_09640	COG2323	membrane
HXZ66_09660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXZ66_09675	COG1686	Belongs to the peptidase S11 family
HXZ66_09680	COG2715	membrane protein required for spore maturation
HXZ66_09685	COG0700	Nucleoside recognition
HXZ66_09690	COG1187	pseudouridine synthase activity
HXZ66_09700	COG1333	cytochrome c biogenesis protein
HXZ66_09705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXZ66_09710	COG0745	RESPONSE REGULATOR receiver
HXZ66_09715	COG5002	protein histidine kinase activity
HXZ66_09720	COG0521	Mo-molybdopterin cofactor biosynthetic process
HXZ66_09725	COG2096	Adenosyltransferase
HXZ66_09735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXZ66_09745	COG1141	Ferredoxin
HXZ66_09750	COG4955	Helix-turn-helix domain
HXZ66_09755	COG0514	ATP-dependent DNA helicase (RecQ)
HXZ66_09760	COG1266	CAAX protease self-immunity
HXZ66_09785	COG1408	metallophosphoesterase
HXZ66_09790	COG0789	Transcriptional regulator
HXZ66_09795	COG4862	establishment of competence for transformation
HXZ66_09800	COG0492	ferredoxin-NADP+ reductase activity
HXZ66_09805	COG0252	asparaginase activity
HXZ66_09810	COG2339	peptidase activity
HXZ66_09820	COG3409	Peptidoglycan-binding domain 1 protein
HXZ66_09820	COG3773	Cell wall hydrolase
HXZ66_09825	COG2959	enzyme of heme biosynthesis
HXZ66_09835	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HXZ66_09845	COG0539	negative regulation of cytoplasmic translation
HXZ66_09850	COG1304	FMN binding
HXZ66_09860	COG1160	GTP binding
HXZ66_09865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HXZ66_09890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HXZ66_09900	COG0302	gtp cyclohydrolase
HXZ66_09910	COG0142	geranyltranstransferase activity
HXZ66_09920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HXZ66_09925	COG0163	prenyltransferase activity
HXZ66_09930	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HXZ66_09935	COG0142	geranyltranstransferase activity
HXZ66_09940	COG0105	UTP biosynthetic process
HXZ66_09945	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HXZ66_09950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HXZ66_09955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXZ66_09960	COG4401	Chorismate mutase type I
HXZ66_09970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HXZ66_09975	COG0134	indole-3-glycerol-phosphate synthase activity
HXZ66_09980	COG0133	tryptophan synthase activity
HXZ66_09985	COG0159	tryptophan synthase activity
HXZ66_09990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXZ66_09995	COG0287	Prephenate dehydrogenase
HXZ66_10000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HXZ66_10015	COG5582	Belongs to the UPF0302 family
HXZ66_10025	COG0723	plastoquinol--plastocyanin reductase activity
HXZ66_10030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HXZ66_10035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HXZ66_10035	COG2010	Cytochrome c
HXZ66_10040	COG4347	Protein of unknown function (DUF1405)
HXZ66_10050	COG2738	Putative neutral zinc metallopeptidase
HXZ66_10055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HXZ66_10060	COG1694	Mazg nucleotide pyrophosphohydrolase
HXZ66_10065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HXZ66_10070	COG1803	Methylglyoxal synthase
HXZ66_10075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXZ66_10080	COG0438	transferase activity, transferring glycosyl groups
HXZ66_10085	COG0617	tRNA 3'-terminal CCA addition
HXZ66_10100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HXZ66_10105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HXZ66_10110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXZ66_10110	COG1199	ATP-dependent helicase activity
HXZ66_10115	COG0402	S-adenosylhomocysteine deaminase activity
HXZ66_10130	COG0436	Aminotransferase
HXZ66_10135	COG0017	Asparaginyl-tRNA synthetase
HXZ66_10140	COG3935	DnaD domain protein
HXZ66_10145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HXZ66_10155	COG4499	WXG100 protein secretion system (Wss), protein YukC
HXZ66_10155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXZ66_10170	COG0789	Transcriptional regulator
HXZ66_10190	COG1335	isochorismatase
HXZ66_10200	COG2391	methyltransferase activity
HXZ66_10205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXZ66_10210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXZ66_10220	COG1413	lyase activity
HXZ66_10230	COG3402	PFAM membrane-flanked domain
HXZ66_10235	COG3428	Bacterial PH domain
HXZ66_10245	COG1191	sigma factor activity
HXZ66_10270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXZ66_10275	COG0805	protein transport
HXZ66_10290	COG0038	chloride channel
HXZ66_10295	COG1428	Deoxynucleoside kinase
HXZ66_10300	COG1428	Deoxynucleoside kinase
HXZ66_10315	COG2814	Major facilitator Superfamily
HXZ66_10330	COG2322	membrane
HXZ66_10340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXZ66_10350	COG0114	fumarate hydratase activity
HXZ66_10365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXZ66_10370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXZ66_10385	COG1686	Belongs to the peptidase S11 family
HXZ66_10390	COG0657	acetylesterase activity
HXZ66_10400	COG0436	Aminotransferase
HXZ66_10405	COG0567	Dehydrogenase, E1 component
HXZ66_10410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXZ66_10420	COG2311	Membrane
HXZ66_10445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXZ66_10455	COG0346	lactoylglutathione lyase activity
HXZ66_10465	COG0346	lactoylglutathione lyase activity
HXZ66_10470	COG1278	Cold shock
HXZ66_10475	COG1063	alcohol dehydrogenase
HXZ66_10490	COG1597	lipid kinase activity
HXZ66_10495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXZ66_10500	COG0739	heme binding
HXZ66_10500	COG0741	lytic transglycosylase activity
HXZ66_10500	COG1196	nuclear chromosome segregation
HXZ66_10515	COG0386	Belongs to the glutathione peroxidase family
HXZ66_10535	COG2235	arginine
HXZ66_10540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HXZ66_10555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXZ66_10570	COG1832	CoA-binding protein
HXZ66_10575	COG0187	DNA topoisomerase II activity
HXZ66_10580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HXZ66_10585	COG0697	spore germination
HXZ66_10605	COG2357	RelA SpoT domain protein
HXZ66_10610	COG3584	3D domain protein
HXZ66_10610	COG3583	domain protein
HXZ66_10630	COG0561	phosphatase activity
HXZ66_10635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HXZ66_10660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HXZ66_10665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXZ66_10670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXZ66_10700	COG1408	metallophosphoesterase
HXZ66_10710	COG2996	Protein conserved in bacteria
HXZ66_10715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HXZ66_10735	COG0004	ammonium transporteR
HXZ66_10740	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HXZ66_10750	COG3830	Belongs to the UPF0237 family
HXZ66_10765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HXZ66_10775	COG1217	gtp-binding protein TYPA
HXZ66_10785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HXZ66_10790	COG1917	Cupin 2, conserved barrel domain protein
HXZ66_10795	COG3180	Ammonia monooxygenase
HXZ66_10800	COG3011	Protein conserved in bacteria
HXZ66_10805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_10810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXZ66_10820	COG4637	Psort location Cytoplasmic, score
HXZ66_10830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HXZ66_10835	COG0165	Argininosuccinate lyase
HXZ66_10840	COG0137	argininosuccinate synthase activity
HXZ66_10845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXZ66_10850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXZ66_10855	COG0505	Belongs to the CarA family
HXZ66_10860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXZ66_10865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXZ66_10870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HXZ66_10875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HXZ66_10880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXZ66_10885	COG0346	lactoylglutathione lyase activity
HXZ66_10890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXZ66_10895	COG1764	response to oxidative stress
HXZ66_10900	COG1511	domain protein
HXZ66_10905	COG1309	transcriptional regulator
HXZ66_10925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXZ66_10935	COG0602	queuosine metabolic process
HXZ66_10940	COG1328	CTP reductase activity
HXZ66_10945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXZ66_10950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXZ66_10960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HXZ66_10960	COG2105	PFAM AIG2 family protein
HXZ66_10970	COG1012	belongs to the aldehyde dehydrogenase family
HXZ66_10970	COG1454	alcohol dehydrogenase
HXZ66_10985	COG0488	(ABC) transporter
HXZ66_10995	COG0419	ATPase involved in DNA repair
HXZ66_11000	COG0420	3'-5' exonuclease activity
HXZ66_11005	COG1074	ATP-dependent DNA helicase activity
HXZ66_11010	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HXZ66_11020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXZ66_11025	COG0398	Pfam SNARE associated Golgi protein
HXZ66_11030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXZ66_11055	COG0456	acetyltransferase
HXZ66_11065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXZ66_11090	COG0628	permease
HXZ66_11095	COG1408	metallophosphoesterase
HXZ66_11100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXZ66_11120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXZ66_11125	COG1216	Glycosyl transferase, family 2
HXZ66_11125	COG1442	glycosyl transferase family 8
HXZ66_11130	COG1132	(ABC) transporter
HXZ66_11140	COG0438	transferase activity, transferring glycosyl groups
HXZ66_11145	COG1216	Glycosyl transferase, family 2
HXZ66_11145	COG1442	glycosyl transferase family 8
HXZ66_11150	COG1216	Glycosyl transferase, family 2
HXZ66_11155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HXZ66_11160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HXZ66_11165	COG1216	Glycosyl transferase, family 2
HXZ66_11165	COG1442	glycosyl transferase family 8
HXZ66_11170	COG0438	transferase activity, transferring glycosyl groups
HXZ66_11175	COG0438	transferase activity, transferring glycosyl groups
HXZ66_11190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXZ66_11205	COG0463	Glycosyl transferase, family 2
HXZ66_11210	COG0438	transferase activity, transferring glycosyl groups
HXZ66_11215	COG0438	transferase activity, transferring glycosyl groups
HXZ66_11220	COG1086	Polysaccharide biosynthesis protein
HXZ66_11225	COG0489	protein tyrosine kinase activity
HXZ66_11230	COG3944	biosynthesis protein
HXZ66_11235	COG1115	amino acid carrier protein
HXZ66_11240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HXZ66_11250	COG1183	phosphatidylcholine synthase activity
HXZ66_11255	COG0438	transferase activity, transferring glycosyl groups
HXZ66_11255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXZ66_11260	COG2267	carboxylic ester hydrolase activity
HXZ66_11265	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_11270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HXZ66_11280	COG0205	6-phosphofructokinase activity
HXZ66_11285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXZ66_11290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXZ66_11295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXZ66_11305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HXZ66_11325	COG0116	Belongs to the methyltransferase superfamily
HXZ66_11335	COG0328	RNA-DNA hybrid ribonuclease activity
HXZ66_11340	COG3599	regulation of cell shape
HXZ66_11345	COG4474	Belongs to the UPF0398 family
HXZ66_11360	COG4443	Transcriptional Coactivator p15 (PC4)
HXZ66_11370	COG2273	Hydrolase Family 16
HXZ66_11375	COG1201	RNA secondary structure unwinding
HXZ66_11400	COG3359	exonuclease
HXZ66_11405	COG1111	helicase
HXZ66_11405	COG1205	dead DEAH box helicase
HXZ66_11410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HXZ66_11415	COG2070	2-Nitropropane dioxygenase
HXZ66_11430	COG1122	ATPase activity
HXZ66_11450	COG3858	chitin binding
HXZ66_11455	COG2814	Major facilitator Superfamily
HXZ66_11465	COG0693	protein deglycase activity
HXZ66_11470	COG0791	NLP P60 protein
HXZ66_11470	COG1388	LysM domain
HXZ66_11480	COG1418	mRNA catabolic process
HXZ66_11490	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXZ66_11500	COG1151	hydroxylamine reductase activity
HXZ66_11510	COG0835	chemotaxis
HXZ66_11510	COG0784	Response regulator, receiver
HXZ66_11520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXZ66_11560	COG2814	Major facilitator Superfamily
HXZ66_11565	COG2200	EAL domain
HXZ66_11570	COG0613	PHP domain protein
HXZ66_11575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HXZ66_11590	COG0824	Thioesterase
HXZ66_11595	COG0464	growth
HXZ66_11600	COG0697	spore germination
HXZ66_11605	COG0398	Pfam SNARE associated Golgi protein
HXZ66_11625	COG2323	membrane
HXZ66_11630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HXZ66_11660	COG3583	domain protein
HXZ66_11660	COG3584	3D domain protein
HXZ66_11665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HXZ66_11670	COG0346	lactoylglutathione lyase activity
HXZ66_11675	COG0471	metal ion transport
HXZ66_11700	COG1131	(ABC) transporter
HXZ66_11715	COG3279	Response regulator of the LytR AlgR family
HXZ66_11725	COG2027	D-alanyl-D-alanine carboxypeptidase
HXZ66_11730	COG2027	D-alanyl-D-alanine carboxypeptidase
HXZ66_11745	COG2390	Transcriptional regulator
HXZ66_11755	COG3732	PTS system glucitol sorbitol-specific
HXZ66_11760	COG3730	PTS system glucitol sorbitol-specific
HXZ66_11785	COG4846	Membrane protein involved in cytochrome C biogenesis
HXZ66_11795	COG1937	Protein conserved in bacteria
HXZ66_11800	COG1132	(ABC) transporter
HXZ66_11805	COG1132	(ABC) transporter
HXZ66_11810	COG3763	UPF0154 protein
HXZ66_11820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HXZ66_11825	COG4224	UPF0291 protein
HXZ66_11830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HXZ66_11840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HXZ66_11845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXZ66_11850	COG0753	catalase activity
HXZ66_11860	COG2116	formate transmembrane transporter activity
HXZ66_11865	COG1587	Uroporphyrinogen-III synthase
HXZ66_11865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXZ66_11870	COG2146	nitrite reductase [NAD(P)H] activity
HXZ66_11875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXZ66_11885	COG3711	transcriptional antiterminator
HXZ66_11890	COG2723	6-phospho-beta-galactosidase activity
HXZ66_11895	COG2190	(PTS) system
HXZ66_11895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_11895	COG1263	PTS System
HXZ66_11905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HXZ66_11950	COG0174	glutamine synthetase
HXZ66_11955	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HXZ66_11960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HXZ66_11965	COG0464	growth
HXZ66_11970	COG1923	regulation of RNA biosynthetic process
HXZ66_11975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HXZ66_11980	COG2136	Putative SAM-dependent methyltransferase
HXZ66_11980	COG2521	methyltransferase
HXZ66_11985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HXZ66_11990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HXZ66_12000	COG4550	Control of competence regulator ComK, YlbF/YmcA
HXZ66_12005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXZ66_12010	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXZ66_12015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXZ66_12015	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXZ66_12020	COG2359	stage V sporulation protein S
HXZ66_12025	COG1692	metallophosphoesterase
HXZ66_12030	COG1418	mRNA catabolic process
HXZ66_12040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HXZ66_12045	COG0513	Belongs to the DEAD box helicase family
HXZ66_12050	COG1546	Belongs to the CinA family
HXZ66_12050	COG1058	Belongs to the CinA family
HXZ66_12055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HXZ66_12060	COG1426	Protein conserved in bacteria
HXZ66_12075	COG0300	oxidoreductase activity
HXZ66_12080	COG0612	Peptidase, M16
HXZ66_12085	COG0612	Peptidase, M16
HXZ66_12090	COG2188	Transcriptional regulator
HXZ66_12095	COG1674	ftsk spoiiie
HXZ66_12105	COG0740	serine-type endopeptidase activity
HXZ66_12110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HXZ66_12120	COG0527	aspartate kinase activity
HXZ66_12125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HXZ66_12130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HXZ66_12135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXZ66_12140	COG1873	PFAM PRC-barrel domain
HXZ66_12145	COG0612	Peptidase, M16
HXZ66_12150	COG0726	polysaccharide deacetylase
HXZ66_12155	COG1185	polyribonucleotide nucleotidyltransferase activity
HXZ66_12160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HXZ66_12165	COG0196	riboflavin kinase activity
HXZ66_12175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HXZ66_12180	COG1550	Protein conserved in bacteria
HXZ66_12185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HXZ66_12190	COG1358	cellular component organization or biogenesis
HXZ66_12195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HXZ66_12200	COG0195	Participates in both transcription termination and antitermination
HXZ66_12205	COG0779	Required for maturation of 30S ribosomal subunits
HXZ66_12210	COG2176	DNA-directed DNA polymerase activity
HXZ66_12215	COG0442	prolyl-tRNA aminoacylation
HXZ66_12220	COG0750	zinc metalloprotease
HXZ66_12225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HXZ66_12230	COG4589	Belongs to the CDS family
HXZ66_12235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXZ66_12240	COG0233	cytoplasmic translational termination
HXZ66_12245	COG0528	UMP kinase activity
HXZ66_12250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HXZ66_12255	COG0052	Belongs to the universal ribosomal protein uS2 family
HXZ66_12275	COG1191	sigma factor activity
HXZ66_12285	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HXZ66_12290	COG1776	CheC inhibitor of MCP methylation
HXZ66_12295	COG0835	chemotaxis
HXZ66_12300	COG0643	Histidine kinase
HXZ66_12300	COG2198	Histidine kinase
HXZ66_12305	COG2201	protein-glutamate methylesterase activity
HXZ66_12310	COG0455	bacterial-type flagellum organization
HXZ66_12315	COG1419	protein localization to endoplasmic reticulum
HXZ66_12320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXZ66_12325	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXZ66_12330	COG1684	flagellar biosynthetic protein fliR
HXZ66_12335	COG1987	bacterial-type flagellum assembly
HXZ66_12340	COG1338	Plays a role in the flagellum-specific transport system
HXZ66_12345	COG3190	flagellar
HXZ66_12350	COG2201	protein-glutamate methylesterase activity
HXZ66_12355	COG1776	CheC inhibitor of MCP methylation
HXZ66_12355	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXZ66_12360	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXZ66_12365	COG1580	Controls the rotational direction of flagella during chemotaxis
HXZ66_12370	COG1582	Flagellar protein (FlbD)
HXZ66_12375	COG4786	Flagellar basal body rod
HXZ66_12385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HXZ66_12405	COG1157	protein secretion by the type III secretion system
HXZ66_12410	COG1317	bacterial-type flagellum organization
HXZ66_12415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXZ66_12420	COG1766	The M ring may be actively involved in energy transduction
HXZ66_12425	COG1677	Flagellar hook-basal body complex protein FliE
HXZ66_12430	COG1558	bacterial-type flagellum-dependent cell motility
HXZ66_12435	COG1815	bacterial-type flagellum-dependent cell motility
HXZ66_12440	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HXZ66_12445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HXZ66_12450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HXZ66_12455	COG4974	Belongs to the 'phage' integrase family
HXZ66_12460	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HXZ66_12465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HXZ66_12470	COG0758	DNA mediated transformation
HXZ66_12475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HXZ66_12480	COG0045	succinate-CoA ligase (ADP-forming) activity
HXZ66_12490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXZ66_12500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HXZ66_12515	COG0335	large ribosomal subunit rRNA binding
HXZ66_12520	COG0336	Belongs to the RNA methyltransferase TrmD family
HXZ66_12525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HXZ66_12535	COG1837	Belongs to the UPF0109 family
HXZ66_12540	COG0228	four-way junction DNA binding
HXZ66_12545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HXZ66_12550	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HXZ66_12555	COG0552	protein localization to endoplasmic reticulum
HXZ66_12560	COG1196	nuclear chromosome segregation
HXZ66_12565	COG4840	Belongs to the UPF0435 family
HXZ66_12570	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXZ66_12590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXZ66_12595	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_12600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HXZ66_12610	COG1349	DNA-binding transcription factor activity
HXZ66_12615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HXZ66_12620	COG1760	l-serine dehydratase
HXZ66_12625	COG1760	l-serine dehydratase
HXZ66_12630	COG1307	EDD domain protein, DegV family
HXZ66_12635	COG1461	Dihydroxyacetone kinase
HXZ66_12640	COG1302	Protein conserved in bacteria
HXZ66_12645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXZ66_12655	COG1564	THIamine pyrophosphokinase
HXZ66_12660	COG3859	Proton-coupled thiamine transporter YuaJ
HXZ66_12665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HXZ66_12670	COG1162	GTPase activity
HXZ66_12675	COG0515	serine threonine protein kinase
HXZ66_12675	COG2815	serine threonine protein kinase
HXZ66_12680	COG0631	protein serine/threonine phosphatase activity
HXZ66_12685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXZ66_12685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXZ66_12690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HXZ66_12695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HXZ66_12700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HXZ66_12705	COG1758	RNA polymerase activity
HXZ66_12710	COG0194	GDP metabolic process
HXZ66_12715	COG2052	Domain of unknown function (DUF370)
HXZ66_12720	COG1561	YicC-like family, N-terminal region
HXZ66_12730	COG1132	(ABC) transporter
HXZ66_12735	COG1132	(ABC) transporter
HXZ66_12745	COG0284	orotidine-5'-phosphate decarboxylase activity
HXZ66_12750	COG0167	dihydroorotate dehydrogenase activity
HXZ66_12755	COG0543	2 iron, 2 sulfur cluster binding
HXZ66_12760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXZ66_12765	COG0505	Belongs to the CarA family
HXZ66_12770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXZ66_12775	COG0540	Belongs to the ATCase OTCase family
HXZ66_12785	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HXZ66_12790	COG0564	pseudouridine synthase activity
HXZ66_12795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HXZ66_12800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HXZ66_12805	COG3599	regulation of cell shape
HXZ66_12810	COG2302	S4 RNA-binding domain
HXZ66_12815	COG0762	integral membrane protein
HXZ66_12820	COG1799	cell septum assembly
HXZ66_12825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HXZ66_12830	COG1873	PFAM PRC-barrel domain
HXZ66_12835	COG1191	sigma factor activity
HXZ66_12840	COG1191	sigma factor activity
HXZ66_12850	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HXZ66_12855	COG0849	cell division
HXZ66_12860	COG3856	small basic protein
HXZ66_12865	COG3879	Bacterial protein of unknown function (DUF881)
HXZ66_12870	COG3879	Bacterial protein of unknown function (DUF881)
HXZ66_12875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HXZ66_12880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HXZ66_12885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXZ66_12890	COG0772	Belongs to the SEDS family
HXZ66_12895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HXZ66_12900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HXZ66_12910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HXZ66_12915	COG0768	penicillin binding
HXZ66_12920	COG0768	penicillin binding
HXZ66_12930	COG0275	rRNA processing
HXZ66_12935	COG2001	Belongs to the MraZ family
HXZ66_12940	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HXZ66_12950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HXZ66_12955	COG0454	-acetyltransferase
HXZ66_12965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HXZ66_12975	COG1323	Belongs to the UPF0348 family
HXZ66_12980	COG3480	Lon protease (S16) C-terminal proteolytic domain
HXZ66_12985	COG3314	Sporulation integral membrane protein YlbJ
HXZ66_12990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HXZ66_12995	COG0742	ribosomal rna small subunit methyltransferase
HXZ66_13000	COG4471	UPF0298 protein
HXZ66_13005	COG3679	Belongs to the UPF0342 family
HXZ66_13020	COG2340	Cysteine-rich secretory protein family
HXZ66_13025	COG0517	IMP dehydrogenase activity
HXZ66_13035	COG0628	permease
HXZ66_13045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HXZ66_13050	COG1845	cytochrome c oxidase, subunit III
HXZ66_13055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HXZ66_13060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HXZ66_13060	COG2010	Cytochrome c
HXZ66_13065	COG0109	protoheme IX farnesyltransferase activity
HXZ66_13070	COG1612	heme a metabolic process
HXZ66_13075	COG0783	Belongs to the Dps family
HXZ66_13080	COG4838	Belongs to the UPF0358 family
HXZ66_13085	COG2066	Belongs to the glutaminase family
HXZ66_13095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HXZ66_13115	COG4896	Protein conserved in bacteria
HXZ66_13130	COG0483	inositol monophosphate 1-phosphatase activity
HXZ66_13140	COG4493	Belongs to the UPF0637 family
HXZ66_13145	COG4476	Belongs to the UPF0223 family
HXZ66_13150	COG1982	Orn Lys Arg decarboxylase major
HXZ66_13170	COG0726	polysaccharide deacetylase
HXZ66_13175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HXZ66_13180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXZ66_13190	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXZ66_13195	COG0022	dehydrogenase e1 component
HXZ66_13220	COG5503	Protein of unknown function (DUF1447)
HXZ66_13225	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HXZ66_13230	COG0569	domain protein
HXZ66_13235	COG0450	alkyl hydroperoxide reductase
HXZ66_13240	COG0668	transmembrane transport
HXZ66_13250	COG1473	amidohydrolase
HXZ66_13255	COG2171	N-acyltransferase activity
HXZ66_13260	COG0561	phosphatase activity
HXZ66_13275	COG0668	transmembrane transport
HXZ66_13280	COG0589	response to stress
HXZ66_13285	COG0569	domain protein
HXZ66_13290	COG1136	(ABC) transporter
HXZ66_13295	COG0071	Belongs to the small heat shock protein (HSP20) family
HXZ66_13305	COG0778	Nitroreductase
HXZ66_13310	COG1854	S-ribosylhomocysteine lyase activity
HXZ66_13320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HXZ66_13330	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_13335	COG1312	Catalyzes the dehydration of D-mannonate
HXZ66_13340	COG1802	Transcriptional regulator
HXZ66_13355	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HXZ66_13365	COG0697	spore germination
HXZ66_13390	COG0493	'glutamate synthase
HXZ66_13395	COG0070	glutamate synthase
HXZ66_13395	COG0069	glutamate synthase activity
HXZ66_13395	COG0067	glutamate synthase
HXZ66_13415	COG3858	chitin binding
HXZ66_13415	COG1388	LysM domain
HXZ66_13420	COG0747	negative chemotaxis
HXZ66_13425	COG3883	PFAM NLP P60 protein
HXZ66_13425	COG0791	NLP P60 protein
HXZ66_13455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXZ66_13460	COG0765	amino acid transport
HXZ66_13470	COG1073	alpha beta
HXZ66_13475	COG1278	Cold shock
HXZ66_13485	COG0535	radical SAM domain protein
HXZ66_13490	COG2188	Transcriptional regulator
HXZ66_13515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXZ66_13520	COG0457	Tetratricopeptide repeat
HXZ66_13520	COG0463	Glycosyl transferase, family 2
HXZ66_13545	COG0673	inositol 2-dehydrogenase activity
HXZ66_13605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HXZ66_13610	COG0564	pseudouridine synthase activity
HXZ66_13615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HXZ66_13620	COG2357	RelA SpoT domain protein
HXZ66_13630	COG4116	CYTH
HXZ66_13635	COG0741	lytic transglycosylase activity
HXZ66_13640	COG2346	COG2346, Truncated hemoglobins
HXZ66_13645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HXZ66_13655	COG1164	Oligoendopeptidase f
HXZ66_13675	COG4862	establishment of competence for transformation
HXZ66_13680	COG0861	Integral membrane protein TerC family
HXZ66_13685	COG1393	Belongs to the ArsC family
HXZ66_13690	COG0456	acetyltransferase
HXZ66_13700	COG1418	mRNA catabolic process
HXZ66_13715	COG0180	Tryptophanyl-tRNA synthetase
HXZ66_13730	COG5504	Zn-dependent protease
HXZ66_13740	COG2197	response regulator
HXZ66_13745	COG4585	Histidine kinase
HXZ66_13750	COG4758	membrane
HXZ66_13765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXZ66_13770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXZ66_13780	COG1744	ABC transporter substrate-binding protein PnrA-like
HXZ66_13805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXZ66_13810	COG2223	nitrite transmembrane transporter activity
HXZ66_13825	COG0437	4 iron, 4 sulfur cluster binding
HXZ66_13830	COG0243	molybdopterin cofactor binding
HXZ66_13845	COG3833	ABC-type maltose transport systems, permease component
HXZ66_13850	COG1175	transmembrane transport
HXZ66_13865	COG4841	protein insertion into membrane
HXZ66_13870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXZ66_13875	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HXZ66_13880	COG0314	molybdopterin synthase activity
HXZ66_13885	COG1763	Mo-molybdopterin cofactor biosynthetic process
HXZ66_13890	COG0303	'Molybdopterin
HXZ66_13895	COG1999	signal sequence binding
HXZ66_13900	COG3336	cytochrome c oxidase
HXZ66_13905	COG0561	phosphatase activity
HXZ66_13930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXZ66_13940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HXZ66_13955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXZ66_13960	COG0628	permease
HXZ66_13965	COG1609	Transcriptional regulator
HXZ66_13975	COG0534	Mate efflux family protein
HXZ66_13990	COG1737	Transcriptional regulator
HXZ66_13995	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXZ66_14000	COG1509	lysine 2,3-aminomutase activity
HXZ66_14015	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXZ66_14030	COG0785	Cytochrome C biogenesis protein
HXZ66_14035	COG3706	GGDEF domain
HXZ66_14035	COG5001	Diguanylate cyclase
HXZ66_14035	COG2203	Gaf domain
HXZ66_14035	COG4251	negative regulation of phosphorylation
HXZ66_14040	COG2154	pterin-4-alpha-carbinolamine dehydratase
HXZ66_14045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HXZ66_14055	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HXZ66_14060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXZ66_14065	COG1309	transcriptional regulator
HXZ66_14080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXZ66_14120	COG3300	MHYT domain
HXZ66_14120	COG5001	Diguanylate cyclase
HXZ66_14130	COG0686	Belongs to the AlaDH PNT family
HXZ66_14150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_14160	COG2329	Antibiotic biosynthesis monooxygenase
HXZ66_14165	COG4509	Sortase family
HXZ66_14185	COG5386	Cell surface protein
HXZ66_14190	COG5386	Cell surface protein
HXZ66_14195	COG0745	RESPONSE REGULATOR receiver
HXZ66_14200	COG0704	Plays a role in the regulation of phosphate uptake
HXZ66_14205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HXZ66_14210	COG0581	inorganic phosphate transmembrane transporter activity
HXZ66_14215	COG0573	inorganic phosphate transmembrane transporter activity
HXZ66_14220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HXZ66_14225	COG1234	tRNA 3'-trailer cleavage
HXZ66_14235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HXZ66_14240	COG2868	ribosomal protein
HXZ66_14245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HXZ66_14250	COG1530	ribonuclease E activity
HXZ66_14255	COG1994	Peptidase M50
HXZ66_14260	COG0739	heme binding
HXZ66_14265	COG2894	cell division
HXZ66_14270	COG0850	regulation of cytokinetic process
HXZ66_14275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HXZ66_14285	COG1077	Cell shape determining protein MreB Mrl
HXZ66_14290	COG2003	Belongs to the UPF0758 family
HXZ66_14295	COG0424	maF-like protein
HXZ66_14300	COG1027	Aspartate ammonia-lyase
HXZ66_14310	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HXZ66_14315	COG2199	diguanylate cyclase activity
HXZ66_14315	COG2203	Gaf domain
HXZ66_14320	COG0285	dihydrofolate synthase activity
HXZ66_14325	COG0189	ligase activity
HXZ66_14335	COG2197	response regulator
HXZ66_14365	COG0525	valine-tRNA ligase activity
HXZ66_14375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HXZ66_14385	COG1388	LysM domain
HXZ66_14395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXZ66_14400	COG0113	porphobilinogen synthase activity
HXZ66_14410	COG0181	hydroxymethylbilane synthase activity
HXZ66_14415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXZ66_14420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HXZ66_14430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HXZ66_14435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HXZ66_14440	COG0470	DNA polymerase III
HXZ66_14440	COG1067	ATP-dependent peptidase activity
HXZ66_14450	COG0544	peptidyl-prolyl cis-trans isomerase activity
HXZ66_14455	COG0457	Tetratricopeptide repeat
HXZ66_14455	COG1477	protein flavinylation
HXZ66_14460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HXZ66_14465	COG0371	Dehydrogenase
HXZ66_14470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HXZ66_14480	COG0698	ribose 5-phosphate isomerase
HXZ66_14485	COG1063	alcohol dehydrogenase
HXZ66_14490	COG3775	system Galactitol-specific IIC component
HXZ66_14495	COG3414	Phosphotransferase system galactitol-specific IIB component
HXZ66_14510	COG3559	Exporter of polyketide antibiotics
HXZ66_14515	COG1131	(ABC) transporter
HXZ66_14540	COG0622	Phosphoesterase
HXZ66_14545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HXZ66_14555	COG5401	PFAM Sporulation and spore germination
HXZ66_14560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HXZ66_14565	COG1846	Transcriptional regulator
HXZ66_14570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXZ66_14575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_14580	COG3711	transcriptional antiterminator
HXZ66_14585	COG1621	beta-fructofuranosidase activity
HXZ66_14590	COG1621	beta-fructofuranosidase activity
HXZ66_14595	COG1653	transport
HXZ66_14600	COG5578	integral membrane protein
HXZ66_14605	COG0395	ABC-type sugar transport system, permease component
HXZ66_14610	COG4209	transmembrane transport
HXZ66_14615	COG1621	beta-fructofuranosidase activity
HXZ66_14620	COG1609	Transcriptional regulator
HXZ66_14625	COG2197	response regulator
HXZ66_14635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HXZ66_14640	COG1053	succinate dehydrogenase
HXZ66_14645	COG2009	succinate dehydrogenase
HXZ66_14655	COG0531	amino acid
HXZ66_14660	COG0697	spore germination
HXZ66_14665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXZ66_14670	COG1719	4-vinyl reductase, 4VR
HXZ66_14680	COG0322	excinuclease ABC activity
HXZ66_14685	COG3118	belongs to the thioredoxin family
HXZ66_14690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HXZ66_14695	COG2086	electron transfer activity
HXZ66_14700	COG1309	transcriptional regulator
HXZ66_14705	COG0318	PFAM AMP-dependent synthetase and ligase
HXZ66_14710	COG0318	PFAM AMP-dependent synthetase and ligase
HXZ66_14715	COG3766	membrane
HXZ66_14720	COG1193	negative regulation of DNA recombination
HXZ66_14725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HXZ66_14725	COG1796	DNA polymerase
HXZ66_14730	COG1286	toxin biosynthetic process
HXZ66_14735	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HXZ66_14745	COG0072	phenylalanine-tRNA ligase activity
HXZ66_14745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXZ66_14750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HXZ66_14755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXZ66_14765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HXZ66_14770	COG1363	Peptidase, m42
HXZ66_14790	COG3326	Membrane
HXZ66_14795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HXZ66_14800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HXZ66_14805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HXZ66_14810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HXZ66_14820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HXZ66_14825	COG1484	DNA-dependent DNA replication
HXZ66_14830	COG3611	Membrane attachment protein
HXZ66_14835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HXZ66_14845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HXZ66_14850	COG0237	dephospho-CoA kinase activity
HXZ66_14855	COG1971	Probably functions as a manganese efflux pump
HXZ66_14860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HXZ66_14865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXZ66_14865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXZ66_14870	COG5002	protein histidine kinase activity
HXZ66_14875	COG0745	RESPONSE REGULATOR receiver
HXZ66_14880	COG0039	L-malate dehydrogenase activity
HXZ66_14885	COG0538	isocitrate dehydrogenase activity
HXZ66_14890	COG0372	Belongs to the citrate synthase family
HXZ66_14895	COG2707	UPF0756 membrane protein
HXZ66_14900	COG0628	permease
HXZ66_14905	COG3030	protein affecting phage T7 exclusion by the F plasmid
HXZ66_14915	COG0205	6-phosphofructokinase activity
HXZ66_14920	COG0825	malonyl-CoA metabolic process
HXZ66_14925	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HXZ66_14935	COG0281	malic enzyme
HXZ66_14940	COG0587	DNA-directed DNA polymerase activity
HXZ66_14955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HXZ66_14965	COG4109	DRTGG domain
HXZ66_14975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HXZ66_14980	COG0006	proline dipeptidase activity
HXZ66_14990	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_15005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HXZ66_15010	COG0827	DNA restriction-modification system
HXZ66_15015	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HXZ66_15020	COG3874	Sporulation protein YtfJ
HXZ66_15030	COG1714	RDD family
HXZ66_15035	COG0616	signal peptide processing
HXZ66_15040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HXZ66_15045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HXZ66_15055	COG0301	tRNA thio-modification
HXZ66_15060	COG1104	cysteine desulfurase activity
HXZ66_15070	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HXZ66_15075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HXZ66_15080	COG1309	transcriptional regulator
HXZ66_15085	COG1956	GAF domain-containing protein
HXZ66_15090	COG2199	diguanylate cyclase activity
HXZ66_15090	COG2203	Gaf domain
HXZ66_15095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HXZ66_15125	COG0454	-acetyltransferase
HXZ66_15130	COG0517	IMP dehydrogenase activity
HXZ66_15135	COG0123	including yeast histone deacetylase and acetoin utilization protein
HXZ66_15140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HXZ66_15175	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HXZ66_15175	COG1605	Chorismate mutase
HXZ66_15180	COG0849	cell division
HXZ66_15190	COG4980	gas vesicle protein
HXZ66_15200	COG2309	aminopeptidase activity
HXZ66_15205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXZ66_15225	COG1674	ftsk spoiiie
HXZ66_15230	COG4848	Belongs to the UPF0354 family
HXZ66_15235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXZ66_15250	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HXZ66_15255	COG1363	Peptidase, m42
HXZ66_15265	COG1404	Belongs to the peptidase S8 family
HXZ66_15270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXZ66_15275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HXZ66_15290	COG0510	thiamine kinase activity
HXZ66_15310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HXZ66_15320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXZ66_15325	COG1349	DNA-binding transcription factor activity
HXZ66_15330	COG1187	pseudouridine synthase activity
HXZ66_15335	COG0772	Belongs to the SEDS family
HXZ66_15340	COG0772	Belongs to the SEDS family
HXZ66_15345	COG0655	NAD(P)H dehydrogenase (quinone) activity
HXZ66_15350	COG1733	regulation of RNA biosynthetic process
HXZ66_15355	COG2244	polysaccharide biosynthetic process
HXZ66_15360	COG0432	Pfam Uncharacterised protein family UPF0047
HXZ66_15365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXZ66_15375	COG2081	HI0933 family
HXZ66_15380	COG0495	leucyl-tRNA aminoacylation
HXZ66_15385	COG2814	Major facilitator Superfamily
HXZ66_15395	COG1242	4 iron, 4 sulfur cluster binding
HXZ66_15400	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HXZ66_15410	COG2267	carboxylic ester hydrolase activity
HXZ66_15415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HXZ66_15425	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HXZ66_15430	COG1368	sulfuric ester hydrolase activity
HXZ66_15435	COG1879	ABC-type sugar transport system periplasmic component
HXZ66_15440	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXZ66_15445	COG1129	ABC transporter
HXZ66_15450	COG1869	D-ribose catabolic process
HXZ66_15455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXZ66_15460	COG1609	Transcriptional regulator
HXZ66_15470	COG1136	(ABC) transporter
HXZ66_15475	COG0577	efflux transmembrane transporter activity
HXZ66_15510	COG0745	RESPONSE REGULATOR receiver
HXZ66_15515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HXZ66_15550	COG4824	toxin secretion phage lysis holin
HXZ66_15620	COG0740	serine-type endopeptidase activity
HXZ66_15675	COG0582	viral genome integration into host DNA
HXZ66_15680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HXZ66_15715	COG0305	Participates in initiation and elongation during chromosome replication
HXZ66_15795	COG0084	hydrolase, TatD family'
HXZ66_15805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HXZ66_15815	COG4282	regulation of fungal-type cell wall biogenesis
HXZ66_15825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HXZ66_15830	COG1116	anion transmembrane transporter activity
HXZ66_15835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HXZ66_15840	COG0494	nUDIX hydrolase
HXZ66_15845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXZ66_15850	COG0746	molybdenum cofactor guanylyltransferase activity
HXZ66_15870	COG0840	transmembrane signaling receptor activity
HXZ66_15875	COG0840	transmembrane signaling receptor activity
HXZ66_15890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HXZ66_15895	COG1011	Hydrolase
HXZ66_15900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_15900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXZ66_15900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_15905	COG1105	Belongs to the carbohydrate kinase PfkB family
HXZ66_15910	COG1349	DNA-binding transcription factor activity
HXZ66_15915	COG1937	Protein conserved in bacteria
HXZ66_15925	COG2133	pyrroloquinoline quinone binding
HXZ66_15930	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXZ66_15935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HXZ66_15945	COG1012	belongs to the aldehyde dehydrogenase family
HXZ66_15950	COG0460	homoserine dehydrogenase
HXZ66_15960	COG0006	proline dipeptidase activity
HXZ66_15965	COG2508	Transcriptional regulator
HXZ66_15970	COG0733	neurotransmitter:sodium symporter activity
HXZ66_15975	COG2197	response regulator
HXZ66_15980	COG4585	Histidine kinase
HXZ66_15985	COG3239	Fatty acid desaturase
HXZ66_15990	COG2070	2-Nitropropane dioxygenase
HXZ66_16000	COG1486	melibiose metabolic process
HXZ66_16025	COG0235	Class ii aldolase
HXZ66_16030	COG1454	alcohol dehydrogenase
HXZ66_16035	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_16040	COG4753	response regulator
HXZ66_16040	COG2207	Transcriptional regulator
HXZ66_16045	COG2972	Histidine kinase
HXZ66_16050	COG5578	integral membrane protein
HXZ66_16055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HXZ66_16060	COG0395	ABC-type sugar transport system, permease component
HXZ66_16065	COG1175	transmembrane transport
HXZ66_16070	COG1653	transport
HXZ66_16075	COG2755	lipolytic protein G-D-S-L family
HXZ66_16080	COG0673	inositol 2-dehydrogenase activity
HXZ66_16085	COG1609	Transcriptional regulator
HXZ66_16095	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HXZ66_16115	COG0395	ABC-type sugar transport system, permease component
HXZ66_16120	COG4209	transmembrane transport
HXZ66_16125	COG1653	transport
HXZ66_16130	COG2207	Transcriptional regulator
HXZ66_16135	COG5578	integral membrane protein
HXZ66_16145	COG1472	Belongs to the glycosyl hydrolase 3 family
HXZ66_16150	COG0246	Mannitol dehydrogenase
HXZ66_16155	COG2721	sulfolactate sulfo-lyase activity
HXZ66_16165	COG1904	glucuronate isomerase
HXZ66_16170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXZ66_16175	COG0800	Aldolase
HXZ66_16180	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HXZ66_16205	COG0372	Belongs to the citrate synthase family
HXZ66_16210	COG0583	DNA-binding transcription factor activity
HXZ66_16215	COG1349	DNA-binding transcription factor activity
HXZ66_16225	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_16225	COG3347	Dehydrogenase
HXZ66_16230	COG1349	DNA-binding transcription factor activity
HXZ66_16235	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_16255	COG4585	Histidine kinase
HXZ66_16255	COG2203	Gaf domain
HXZ66_16260	COG2197	response regulator
HXZ66_16290	COG1695	Transcriptional regulator
HXZ66_16305	COG1272	protein, Hemolysin III
HXZ66_16310	COG0402	S-adenosylhomocysteine deaminase activity
HXZ66_16315	COG1012	belongs to the aldehyde dehydrogenase family
HXZ66_16320	COG0662	Cupin 2, conserved barrel domain protein
HXZ66_16340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HXZ66_16350	COG0166	Belongs to the GPI family
HXZ66_16355	COG1979	alcohol dehydrogenase
HXZ66_16360	COG2155	Conserved Protein
HXZ66_16365	COG1098	S1 RNA binding domain
HXZ66_16370	COG0436	Aminotransferase
HXZ66_16375	COG1522	sequence-specific DNA binding
HXZ66_16380	COG1335	isochorismatase
HXZ66_16390	COG0644	oxidoreductase
HXZ66_16395	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HXZ66_16405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXZ66_16415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HXZ66_16420	COG1131	(ABC) transporter
HXZ66_16450	COG1012	belongs to the aldehyde dehydrogenase family
HXZ66_16550	COG1268	BioY protein
HXZ66_16555	COG2056	Na+-H+ antiporter family
HXZ66_16560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HXZ66_16565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HXZ66_16570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HXZ66_16575	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HXZ66_16580	COG3584	3D domain protein
HXZ66_16595	COG1252	NADH dehydrogenase
HXZ66_16600	COG0492	ferredoxin-NADP+ reductase activity
HXZ66_16605	COG0316	Belongs to the HesB IscA family
HXZ66_16610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HXZ66_16620	COG4844	belongs to the
HXZ66_16625	COG1252	NADH dehydrogenase
HXZ66_16630	COG4837	Protein of unknown function (DUF1462)
HXZ66_16635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HXZ66_16645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXZ66_16650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HXZ66_16655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HXZ66_16660	COG0647	UMP catabolic process
HXZ66_16670	COG2445	Protein of unknown function DUF86
HXZ66_16675	COG1494	fructose-1,6-bisphosphatase
HXZ66_16690	COG4470	Protein conserved in bacteria
HXZ66_16700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HXZ66_16705	COG0739	heme binding
HXZ66_16710	COG0733	neurotransmitter:sodium symporter activity
HXZ66_16715	COG1757	Na H antiporter
HXZ66_16725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HXZ66_16730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HXZ66_16740	COG0737	Belongs to the 5'-nucleotidase family
HXZ66_16745	COG0730	response to heat
HXZ66_16750	COG1801	Protein of unknown function DUF72
HXZ66_16760	COG1690	Belongs to the RtcB family
HXZ66_16765	COG2267	carboxylic ester hydrolase activity
HXZ66_16770	COG0563	adenylate kinase activity
HXZ66_16785	COG0454	-acetyltransferase
HXZ66_16810	COG1404	Belongs to the peptidase S8 family
HXZ66_16825	COG0719	Fe-S assembly protein
HXZ66_16830	COG0822	iron-sulfur transferase activity
HXZ66_16835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXZ66_16840	COG0719	Fe-S assembly protein
HXZ66_16845	COG0396	ATPase activity
HXZ66_16855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXZ66_16870	COG1464	Belongs to the NlpA lipoprotein family
HXZ66_16875	COG2011	ABC-type metal ion transport system permease component
HXZ66_16880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HXZ66_16895	COG0509	glycine decarboxylation via glycine cleavage system
HXZ66_16900	COG1393	Belongs to the ArsC family
HXZ66_16905	COG1960	acyl-CoA dehydrogenase activity
HXZ66_16910	COG0183	Belongs to the thiolase family
HXZ66_16915	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXZ66_16915	COG1024	Enoyl-CoA hydratase
HXZ66_16930	COG5577	PFAM Coat F domain
HXZ66_16940	COG0201	protein transport
HXZ66_16945	COG0460	homoserine dehydrogenase
HXZ66_16950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXZ66_16960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HXZ66_16990	COG0129	dihydroxy-acid dehydratase activity
HXZ66_17015	COG4565	transcriptional regulatory protein
HXZ66_17020	COG3290	protein histidine kinase activity
HXZ66_17025	COG1126	abc transporter atp-binding protein
HXZ66_17030	COG0765	amino acid transport
HXZ66_17035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXZ66_17055	COG0523	cobalamin synthesis protein
HXZ66_17060	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HXZ66_17080	COG0457	Tetratricopeptide repeat
HXZ66_17115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HXZ66_17120	COG0557	exoribonuclease II activity
HXZ66_17125	COG1647	Serine aminopeptidase, S33
HXZ66_17135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HXZ66_17140	COG0148	phosphopyruvate hydratase activity
HXZ66_17145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HXZ66_17150	COG0149	triose-phosphate isomerase activity
HXZ66_17155	COG0126	phosphoglycerate kinase activity
HXZ66_17160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HXZ66_17165	COG2390	Transcriptional regulator
HXZ66_17175	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HXZ66_17185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXZ66_17190	COG1481	regulation of sporulation
HXZ66_17195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HXZ66_17200	COG1660	Displays ATPase and GTPase activities
HXZ66_17205	COG1051	belongs to the nudix hydrolase family
HXZ66_17210	COG0492	ferredoxin-NADP+ reductase activity
HXZ66_17215	COG0457	Tetratricopeptide repeat
HXZ66_17220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HXZ66_17220	COG0140	phosphoribosyl-ATP diphosphatase activity
HXZ66_17225	COG0107	imidazoleglycerol-phosphate synthase activity
HXZ66_17230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HXZ66_17235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HXZ66_17240	COG0131	Imidazoleglycerol-phosphate dehydratase
HXZ66_17245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HXZ66_17250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HXZ66_17255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HXZ66_17260	COG0110	maltose O-acetyltransferase activity
HXZ66_17265	COG0546	phosphoglycolate phosphatase activity
HXZ66_17270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HXZ66_17275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HXZ66_17280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HXZ66_17285	COG1950	PFAM Membrane protein of
HXZ66_17295	COG3595	metallopeptidase activity
HXZ66_17300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXZ66_17305	COG0556	nucleotide-excision repair
HXZ66_17310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXZ66_17315	COG0793	Belongs to the peptidase S41A family
HXZ66_17315	COG3409	Peptidoglycan-binding domain 1 protein
HXZ66_17320	COG1196	nuclear chromosome segregation
HXZ66_17320	COG0741	lytic transglycosylase activity
HXZ66_17320	COG0739	heme binding
HXZ66_17325	COG2177	Part of the ABC transporter FtsEX involved in
HXZ66_17330	COG2884	Cell division ATP-binding protein ftsE
HXZ66_17340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HXZ66_17350	COG0653	protein targeting
HXZ66_17355	COG3711	transcriptional antiterminator
HXZ66_17360	COG1263	PTS System
HXZ66_17360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_17360	COG2190	(PTS) system
HXZ66_17365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HXZ66_17370	COG1278	Cold shock
HXZ66_17380	COG0629	single-stranded DNA binding
HXZ66_17415	COG1131	(ABC) transporter
HXZ66_17430	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HXZ66_17435	COG1609	Transcriptional regulator
HXZ66_17440	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HXZ66_17450	COG3345	alpha-galactosidase
HXZ66_17455	COG0395	ABC-type sugar transport system, permease component
HXZ66_17460	COG1175	transmembrane transport
HXZ66_17470	COG2942	2-epimerase
HXZ66_17475	COG3458	cephalosporin-C deacetylase activity
HXZ66_17500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXZ66_17510	COG1070	Carbohydrate kinase
HXZ66_17515	COG2115	Belongs to the xylose isomerase family
HXZ66_17530	COG0395	ABC-type sugar transport system, permease component
HXZ66_17535	COG4209	transmembrane transport
HXZ66_17540	COG1653	transport
HXZ66_17545	COG5578	integral membrane protein
HXZ66_17555	COG2972	Histidine kinase
HXZ66_17565	COG1653	transport
HXZ66_17570	COG1175	transmembrane transport
HXZ66_17580	COG3507	Belongs to the glycosyl hydrolase 43 family
HXZ66_17625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HXZ66_17630	COG1516	flagellar protein fliS
HXZ66_17635	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HXZ66_17650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXZ66_17655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXZ66_17660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXZ66_17675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HXZ66_17680	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HXZ66_17690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXZ66_17695	COG1256	bacterial-type flagellum assembly
HXZ66_17695	COG4786	Flagellar basal body rod
HXZ66_17705	COG2747	anti-sigma28 factor FlgM
HXZ66_17720	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HXZ66_17725	COG1307	EDD domain protein, DegV family
HXZ66_17740	COG1739	Uncharacterized protein family UPF0029
HXZ66_17760	COG0679	Auxin Efflux Carrier
HXZ66_17770	COG2268	Band 7 protein
HXZ66_17785	COG0492	ferredoxin-NADP+ reductase activity
HXZ66_17795	COG1874	Beta-galactosidase
HXZ66_17800	COG1609	Transcriptional regulator
HXZ66_17820	COG1653	transport
HXZ66_17825	COG0366	Alpha amylase catalytic
HXZ66_17830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXZ66_17840	COG0395	ABC-type sugar transport system, permease component
HXZ66_17845	COG1175	transmembrane transport
HXZ66_17850	COG1653	transport
HXZ66_17855	COG1609	Transcriptional regulator
HXZ66_17860	COG2207	Transcriptional regulator
HXZ66_17865	COG1486	melibiose metabolic process
HXZ66_17870	COG0840	transmembrane signaling receptor activity
HXZ66_17870	COG3290	protein histidine kinase activity
HXZ66_17875	COG1404	Belongs to the peptidase S8 family
HXZ66_17875	COG4412	M6 family metalloprotease domain protein
HXZ66_17880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXZ66_17885	COG0601	transmembrane transport
HXZ66_17890	COG0747	negative chemotaxis
HXZ66_17895	COG4608	Belongs to the ABC transporter superfamily
HXZ66_17900	COG0444	Belongs to the ABC transporter superfamily
HXZ66_17910	COG0768	penicillin binding
HXZ66_17930	COG3852	Histidine kinase
HXZ66_17940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXZ66_17955	COG4145	pantothenate transmembrane transporter activity
HXZ66_17965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HXZ66_17975	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HXZ66_17985	COG1363	Peptidase, m42
HXZ66_18010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXZ66_18015	COG0326	Molecular chaperone. Has ATPase activity
HXZ66_18020	COG4214	carbohydrate transport
HXZ66_18030	COG4213	ABC transporter substrate-binding protein
HXZ66_18040	COG0840	transmembrane signaling receptor activity
HXZ66_18050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXZ66_18060	COG0653	protein targeting
HXZ66_18090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXZ66_18140	COG2197	response regulator
HXZ66_18145	COG0840	transmembrane signaling receptor activity
HXZ66_18150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HXZ66_18155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HXZ66_18160	COG1316	TRANSCRIPTIONal
HXZ66_18165	COG1316	TRANSCRIPTIONal
HXZ66_18170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HXZ66_18175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HXZ66_18180	COG3940	Belongs to the glycosyl hydrolase 43 family
HXZ66_18190	COG0395	ABC-type sugar transport system, permease component
HXZ66_18195	COG1175	transmembrane transport
HXZ66_18210	COG1511	domain protein
HXZ66_18215	COG0433	COG0433 Predicted ATPase
HXZ66_18215	COG1674	ftsk spoiiie
HXZ66_18220	COG4499	WXG100 protein secretion system (Wss), protein YukC
HXZ66_18225	COG5417	Belongs to the EsaB family
HXZ66_18230	COG4842	Belongs to the WXG100 family
HXZ66_18245	COG0860	N-Acetylmuramoyl-L-alanine amidase
HXZ66_18250	COG1316	TRANSCRIPTIONal
HXZ66_18260	COG1609	Transcriptional regulator
HXZ66_18265	COG5578	integral membrane protein
HXZ66_18270	COG0395	ABC-type sugar transport system, permease component
HXZ66_18275	COG1175	transmembrane transport
HXZ66_18280	COG1653	transport
HXZ66_18285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HXZ66_18285	COG2755	lipolytic protein G-D-S-L family
HXZ66_18295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXZ66_18305	COG0463	Glycosyl transferase, family 2
HXZ66_18310	COG1404	Belongs to the peptidase S8 family
HXZ66_18320	COG4193	domain, Protein
HXZ66_18325	COG1215	transferase activity, transferring glycosyl groups
HXZ66_18340	COG1215	transferase activity, transferring glycosyl groups
HXZ66_18350	COG0438	transferase activity, transferring glycosyl groups
HXZ66_18355	COG0860	N-Acetylmuramoyl-L-alanine amidase
HXZ66_18355	COG2247	cell wall binding repeat
HXZ66_18360	COG1388	LysM domain
HXZ66_18360	COG0791	NLP P60 protein
HXZ66_18380	COG3534	alpha-L-arabinofuranosidase
HXZ66_18385	COG2160	L-arabinose isomerase activity
HXZ66_18390	COG1069	ribulokinase activity
HXZ66_18395	COG0235	Class ii aldolase
HXZ66_18405	COG3534	alpha-L-arabinofuranosidase
HXZ66_18410	COG3507	Belongs to the glycosyl hydrolase 43 family
HXZ66_18415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HXZ66_18420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HXZ66_18425	COG1116	anion transmembrane transporter activity
HXZ66_18430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HXZ66_18435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXZ66_18470	COG1749	Flagellar hook protein flgE
HXZ66_18475	COG4786	Flagellar basal body rod
HXZ66_18480	COG1077	Cell shape determining protein MreB Mrl
HXZ66_18485	COG1609	Transcriptional regulator
HXZ66_18490	COG0739	heme binding
HXZ66_18495	COG2385	sporulation resulting in formation of a cellular spore
HXZ66_18500	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXZ66_18505	COG4836	Membrane
HXZ66_18510	COG1007	ATP synthesis coupled electron transport
HXZ66_18515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXZ66_18520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HXZ66_18530	COG0839	Belongs to the complex I subunit 6 family
HXZ66_18535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXZ66_18540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HXZ66_18545	COG0649	NAD binding
HXZ66_18550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXZ66_18555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXZ66_18565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HXZ66_18570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HXZ66_18575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HXZ66_18580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HXZ66_18585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HXZ66_18590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HXZ66_18600	COG0356	it plays a direct role in the translocation of protons across the membrane
HXZ66_18615	COG1404	Belongs to the peptidase S8 family
HXZ66_18620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HXZ66_18630	COG4475	Protein of unknown function (DUF436)
HXZ66_18635	COG0698	ribose 5-phosphate isomerase
HXZ66_18640	COG0840	transmembrane signaling receptor activity
HXZ66_18650	COG1971	Probably functions as a manganese efflux pump
HXZ66_18655	COG0009	L-threonylcarbamoyladenylate synthase
HXZ66_18670	COG2890	protein-(glutamine-N5) methyltransferase activity
HXZ66_18675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HXZ66_18680	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXZ66_18690	COG1435	thymidine kinase activity
HXZ66_18695	COG0254	rRNA binding
HXZ66_18700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HXZ66_18705	COG1494	fructose-1,6-bisphosphatase
HXZ66_18710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXZ66_18715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HXZ66_18720	COG0191	fructose-bisphosphate aldolase activity
HXZ66_18725	COG2204	response regulator
HXZ66_18735	COG0504	CTP synthase activity
HXZ66_18740	COG3343	RNA polymerase activity
HXZ66_18745	COG2181	nitrate reductase activity
HXZ66_18745	COG0247	lactate metabolic process
HXZ66_18750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXZ66_18755	COG2217	Heavy metal translocating P-type atpase
HXZ66_18760	COG2267	carboxylic ester hydrolase activity
HXZ66_18770	COG0018	arginyl-trna synthetase
HXZ66_18775	COG4506	Protein conserved in bacteria
HXZ66_18780	COG0010	Belongs to the arginase family
HXZ66_18785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HXZ66_18790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXZ66_18805	COG3465	dGTPase activity
HXZ66_18810	COG1078	dGTPase activity
HXZ66_18815	COG4844	belongs to the
HXZ66_18865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HXZ66_18870	COG3285	dna ligase
HXZ66_18870	COG1793	dna ligase
HXZ66_18875	COG0280	phosphate acetyltransferase
HXZ66_18880	COG1902	pentaerythritol trinitrate reductase activity
HXZ66_18880	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXZ66_18885	COG1024	Enoyl-CoA hydratase
HXZ66_18890	COG3253	May function as heme-dependent peroxidase
HXZ66_18900	COG3773	Cell wall hydrolase
HXZ66_18910	COG2363	Small membrane protein
HXZ66_18920	COG0456	acetyltransferase
HXZ66_18935	COG5002	protein histidine kinase activity
HXZ66_18940	COG2084	Dehydrogenase
HXZ66_18945	COG0656	L-ascorbic acid biosynthetic process
HXZ66_18950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HXZ66_18955	COG2201	protein-glutamate methylesterase activity
HXZ66_18960	COG1621	beta-fructofuranosidase activity
HXZ66_18965	COG0840	transmembrane signaling receptor activity
HXZ66_18975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXZ66_18990	COG1368	sulfuric ester hydrolase activity
HXZ66_19000	COG3314	Sporulation integral membrane protein YlbJ
HXZ66_19010	COG0251	oxidation-reduction process
HXZ66_19015	COG1984	allophanate hydrolase subunit 2
HXZ66_19020	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HXZ66_19025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HXZ66_19035	COG2011	ABC-type metal ion transport system permease component
HXZ66_19050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXZ66_19055	COG0371	Dehydrogenase
HXZ66_19060	COG0436	Aminotransferase
HXZ66_19065	COG1072	(Pantothenic acid kinase))
HXZ66_19070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXZ66_19070	COG0723	plastoquinol--plastocyanin reductase activity
HXZ66_19085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXZ66_19100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXZ66_19105	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HXZ66_19125	COG5002	protein histidine kinase activity
HXZ66_19130	COG0745	RESPONSE REGULATOR receiver
HXZ66_19145	COG3706	GGDEF domain
HXZ66_19160	COG2199	diguanylate cyclase activity
HXZ66_19165	COG0673	inositol 2-dehydrogenase activity
HXZ66_19175	COG0460	homoserine dehydrogenase
HXZ66_19180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HXZ66_19185	COG0083	homoserine kinase activity
HXZ66_19195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HXZ66_19200	COG0561	phosphatase activity
HXZ66_19215	COG0527	aspartate kinase activity
HXZ66_19220	COG0747	negative chemotaxis
HXZ66_19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXZ66_19235	COG0444	Belongs to the ABC transporter superfamily
HXZ66_19240	COG4608	Belongs to the ABC transporter superfamily
HXZ66_19245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HXZ66_19250	COG3706	GGDEF domain
HXZ66_19260	COG1607	acyl-coa hydrolase
HXZ66_19270	COG4149	molybdate abc transporter
HXZ66_19275	COG0725	ABC transporter, periplasmic molybdate-binding protein
HXZ66_19280	COG1305	Transglutaminase-like
HXZ66_19285	COG1388	LysM domain
HXZ66_19285	COG0791	NLP P60 protein
HXZ66_19315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HXZ66_19335	COG0492	ferredoxin-NADP+ reductase activity
HXZ66_19340	COG1120	ATPase activity
HXZ66_19345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_19350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_19355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_19385	COG0366	Alpha amylase catalytic
HXZ66_19390	COG0577	efflux transmembrane transporter activity
HXZ66_19395	COG1136	(ABC) transporter
HXZ66_19400	COG2205	protein histidine kinase activity
HXZ66_19405	COG0745	RESPONSE REGULATOR receiver
HXZ66_19410	COG0840	transmembrane signaling receptor activity
HXZ66_19420	COG1132	(ABC) transporter
HXZ66_19445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_19445	COG1263	PTS System
HXZ66_19450	COG1486	melibiose metabolic process
HXZ66_19455	COG1737	Transcriptional regulator
HXZ66_19460	COG4821	SIS domain
HXZ66_19470	COG0501	Belongs to the peptidase M48B family
HXZ66_19520	COG1404	Belongs to the peptidase S8 family
HXZ66_19530	COG0640	Transcriptional regulator
HXZ66_19535	COG0300	oxidoreductase activity
HXZ66_19550	COG3639	organic phosphonate transmembrane transporter activity
HXZ66_19555	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HXZ66_19575	COG0018	arginyl-trna synthetase
HXZ66_19580	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_19590	COG0745	RESPONSE REGULATOR receiver
HXZ66_19595	COG2610	gluconate transmembrane transporter activity
HXZ66_19610	COG1063	alcohol dehydrogenase
HXZ66_19615	COG4187	Peptidase family M20/M25/M40
HXZ66_19620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HXZ66_19675	COG0561	phosphatase activity
HXZ66_19680	COG2723	6-phospho-beta-galactosidase activity
HXZ66_19685	COG1263	PTS System
HXZ66_19685	COG2190	(PTS) system
HXZ66_19685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXZ66_19690	COG3711	transcriptional antiterminator
HXZ66_19695	COG1114	Component of the transport system for branched-chain amino acids
HXZ66_19700	COG0655	NAD(P)H dehydrogenase (quinone) activity
HXZ66_19710	COG2267	carboxylic ester hydrolase activity
HXZ66_19725	COG0673	inositol 2-dehydrogenase activity
HXZ66_19745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HXZ66_19750	COG1522	sequence-specific DNA binding
HXZ66_19755	COG2188	Transcriptional regulator
HXZ66_19765	COG2723	6-phospho-beta-galactosidase activity
HXZ66_19780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXZ66_19785	COG1024	Enoyl-CoA hydratase
HXZ66_19795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXZ66_19800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXZ66_19810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXZ66_19820	COG1028	Short-chain dehydrogenase reductase Sdr
HXZ66_19830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXZ66_19845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXZ66_19865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HXZ66_19870	COG2224	Isocitrate lyase
HXZ66_19875	COG1309	transcriptional regulator
HXZ66_19890	COG0745	RESPONSE REGULATOR receiver
HXZ66_19895	COG5002	protein histidine kinase activity
HXZ66_19900	COG0456	acetyltransferase
HXZ66_19900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HXZ66_19915	COG5578	integral membrane protein
HXZ66_19920	COG0395	ABC-type sugar transport system, permease component
HXZ66_19925	COG1175	transmembrane transport
HXZ66_19935	COG1609	Transcriptional regulator
HXZ66_19945	COG1120	ATPase activity
HXZ66_19950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_19955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXZ66_19960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXZ66_19970	COG0778	Nitroreductase
HXZ66_19975	COG1846	Transcriptional regulator
HXZ66_19985	COG2040	homocysteine
HXZ66_19990	COG1126	abc transporter atp-binding protein
HXZ66_19995	COG0765	amino acid transport
HXZ66_20000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXZ66_20010	COG1733	regulation of RNA biosynthetic process
HXZ66_20015	COG1733	regulation of RNA biosynthetic process
HXZ66_20025	COG0657	acetylesterase activity
HXZ66_20035	COG1733	regulation of RNA biosynthetic process
HXZ66_20055	COG2378	regulation of single-species biofilm formation
HXZ66_20075	COG1131	(ABC) transporter
HXZ66_20080	COG2205	protein histidine kinase activity
HXZ66_20085	COG0745	RESPONSE REGULATOR receiver
HXZ66_20130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HXZ66_20140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXZ66_20145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HXZ66_20150	COG4853	Protein conserved in bacteria
HXZ66_20160	COG5002	protein histidine kinase activity
HXZ66_20165	COG0745	RESPONSE REGULATOR receiver
HXZ66_20200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HXZ66_20210	COG0305	Participates in initiation and elongation during chromosome replication
HXZ66_20215	COG0359	binds to the 23S rRNA
HXZ66_20220	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HXZ66_20230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HXZ66_20235	COG0629	single-stranded DNA binding
HXZ66_20240	COG0360	Binds together with S18 to 16S ribosomal RNA
HXZ66_20245	COG0012	GTP binding
HXZ66_20250	COG4481	Protein conserved in bacteria
HXZ66_20255	COG3949	Membrane
HXZ66_20270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXZ66_20275	COG1475	DNA binding
HXZ66_20280	COG1192	Involved in chromosome partitioning
HXZ66_20285	COG1475	DNA binding
HXZ66_20290	COG0357	Ribosomal RNA small subunit methyltransferase G
HXZ66_20295	COG0445	tRNA wobble uridine modification
HXZ66_20300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HXZ66_20310	COG1510	regulation of RNA biosynthetic process
HXZ66_20320	COG1847	R3H domain protein
HXZ66_20325	COG0706	membrane insertase activity
HXZ66_20330	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HXZ66_20340	COG0230	Belongs to the bacterial ribosomal protein bL34 family