locus-tag class description GD442_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GD442_00015 ENOG410848D S4 domain protein YaaA GD442_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD442_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GD442_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GD442_00100 ENOG4105ZMH deoxynucleoside kinase GD442_00110 ENOG4105GTG Isochorismatase GD442_00115 ENOG4108Z6B deaminase GD442_00125 ENOG4105C6E dna polymerase iii GD442_00145 ENOG41067KS pro-sigma K processing GD442_00180 ENOG4105CXN decarboxylase GD442_00190 ENOG4105FA2 dna polymerase iii GD442_00195 ENOG4105MA4 psp1 domain protein GD442_00205 ENOG41060K3 Methyltransferase GD442_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GD442_00220 ENOG4105KRN Transcriptional regulator, abrb family GD442_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GD442_00230 ENOG4105F8V Hydrolase, tatD family GD442_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GD442_00245 ENOG4105XFA sporulation peptidase YabG GD442_00250 ENOG4105W42 Veg protein GD442_00265 ENOG4105DFT pur operon repressor GD442_00270 ENOG4105KME endoribonuclease L-psp GD442_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GD442_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GD442_00300 ENOG4108JA2 transcriptioN-repair coupling factor GD442_00305 ENOG4108M14 stage v sporulation protein t GD442_00315 ENOG4108IY2 MazG family GD442_00320 ENOG41082I2 s4 domain protein GD442_00325 ENOG4105VYY sporulation protein yabp GD442_00385 ENOG4105C6T cysteine synthase GD442_00390 ENOG4105CRQ synthase (Component I) GD442_00395 ENOG4105DDQ anthranilate synthase GD442_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GD442_00405 ENOG4105EEI dihydropteroate synthase GD442_00410 ENOG4105KRF dihydroneopterin aldolase GD442_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GD442_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GD442_00515 ENOG4108Z0C Uvrb UvrC protein GD442_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GD442_00535 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GD442_00540 ENOG4105CTP PilT protein domain protein GD442_00545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GD442_00560 ENOG4105D7W serine acetyltransferase GD442_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 GD442_00580 ENOG4105M0M Tetracycline resistance protein GD442_00585 ENOG4105QIV RNA polymerase GD442_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GD442_00625 ENOG4107Y49 methyltransferase GD442_00640 ENOG4105XPM ribosomal protein GD442_00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GD442_00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GD442_00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GD442_00790 ENOG41067V7 50S ribosomal protein L36 GD442_00815 ENOG4108JJB ABC transporter GD442_00820 ENOG4108JJB ABC transporter GD442_00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GD442_00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GD442_00855 ENOG4105D1F ATP-binding protein GD442_00870 ENOG4108NMV polysaccharide deacetylase GD442_00950 ENOG4105C8B TIGR00159 family GD442_00955 ENOG4107U5W ybbr family GD442_00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GD442_01005 ENOG4108PSK reductase GD442_01010 ENOG4108UMI ABC transporter, permease GD442_01015 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GD442_01020 ENOG4105D01 (LipO)protein GD442_01025 ENOG4105EE1 crotonyl-CoA reductase GD442_01035 ENOG4105IQ5 FAD linked oxidase domain protein GD442_01050 ENOG4105C2C drug resistance transporter, Bcr CflA GD442_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 GD442_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 GD442_01105 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GD442_01115 ENOG4105E0C molybdate abc transporter GD442_01120 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GD442_01125 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GD442_01135 ENOG4105EGI Transcriptional regulator GD442_01155 ENOG4105F6E Acyl-transferase GD442_01175 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GD442_01190 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GD442_01210 ENOG4105C5H ABC transporter GD442_01220 ENOG4105DEF Extracellular solute-binding protein, family 5 GD442_01230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD442_01235 ENOG4105C3U ABC transporter GD442_01240 ENOG4108JQ7 (ABC) transporter GD442_01245 ENOG410667J hydrolase GD442_01270 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GD442_01275 ENOG4105ERH Fumarylacetoacetate hydrolase GD442_01285 ENOG4105CUB amino acid GD442_01290 ENOG4108SC4 )-transporter GD442_01295 ENOG4105CPF Cell wall formation (By similarity) GD442_01300 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GD442_01325 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GD442_01330 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GD442_01340 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GD442_01445 ENOG4105K8N protein family UPF0079, ATPase GD442_01450 ENOG41072GX Peptidase M22 Glycoprotease GD442_01455 ENOG410801F ribosomal-protein-alanine acetyltransferase GD442_01460 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GD442_01465 ENOG4105C5H ABC transporter GD442_01480 ENOG4108TYN CAAX amino terminal protease family protein GD442_01500 ENOG4105C7N Xanthine uracil vitamin C permease GD442_01510 ENOG4105BZU Histidine kinase GD442_01535 ENOG4107ZXU DSBA oxidoreductase GD442_01580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_01610 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_01620 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GD442_01630 ENOG4108SHN Glycosyl transferase, family 2 GD442_01650 ENOG4105SX7 Transporter GD442_01680 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GD442_01685 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GD442_01690 ENOG4105C83 adenylosuccinate lyase GD442_01700 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GD442_01725 ENOG4108V3E phosphoribosylglycinamide formyltransferase GD442_01735 ENOG4105C12 Phosphoribosylglycinamide synthetase GD442_01760 ENOG4105C4R Atp-dependent dna helicase GD442_01765 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GD442_01785 ENOG4108W2Y isochorismatase GD442_01790 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GD442_01795 ENOG4108UMI ABC transporter, permease GD442_01800 ENOG4105D01 (LipO)protein GD442_01820 ENOG410834F Transcriptional regulator GD442_01825 ENOG4107I77 yiaA/B two helix domain GD442_01845 ENOG4105CBD Diacylglycerol kinase GD442_01855 ENOG4108JPW Aminotransferase GD442_01865 ENOG4105C26 Dehydrogenase GD442_01870 ENOG4105KPY Small multidrug resistance protein GD442_01895 ENOG4105D9N nucleoside GD442_01900 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GD442_01910 ENOG4108W15 Protein of unknown function (DUF1456) GD442_01925 ENOG4105DTQ mandelate racemase muconate lactonizing GD442_01935 ENOG4105DFD Na H antiporter GD442_01960 ENOG4105D3R alkyl hydroperoxide reductase GD442_01965 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GD442_01970 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GD442_01975 ENOG4107W7X Aldolase GD442_01980 ENOG4105EHG Permease protein GD442_01985 ENOG4105DQ5 transport system permease protein GD442_01990 ENOG4108V5C ABC transporter GD442_01995 ENOG4105CAY ferredoxin--nadp reductase GD442_02010 ENOG4106UIA GD442_02015 ENOG4106UIA GD442_02030 ENOG4105BZU Histidine kinase GD442_02050 ENOG410756H nucleotidyltransferase GD442_02070 ENOG4105E5Q amino acid AbC transporter GD442_02075 ENOG4105EAB amino acid AbC transporter GD442_02080 ENOG4105CDA abc transporter atp-binding protein GD442_02085 ENOG4105C8Q Methyl-accepting chemotaxis GD442_02100 ENOG4105DBV ornithine carbamoyltransferase GD442_02110 ENOG4105C5B carbamate kinase GD442_02115 ENOG4108W63 CRP FNR family transcriptional regulator GD442_02125 ENOG4105DNP FAD linked oxidase domain protein GD442_02135 ENOG4105CI1 PTS System GD442_02150 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_02165 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GD442_02185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GD442_02190 ENOG4105D2X ABC transporter substrate-binding protein GD442_02200 ENOG4105C5H ABC transporter GD442_02230 ENOG41062JF Transcriptional regulator GD442_02245 ENOG4105DEU major facilitator superfamily GD442_02260 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GD442_02275 ENOG4108N0M stress protein GD442_02280 ENOG4106FN3 tellurium resistance protein GD442_02285 ENOG4106FN3 tellurium resistance protein GD442_02290 ENOG4107TS3 membrane protein, TerC GD442_02295 ENOG4108TTB tellurium resistance protein GD442_02310 ENOG41068PA UPF0435 protein GD442_02315 ENOG4105KJF protein tyrosine phosphatase GD442_02325 ENOG4107U9T Pfam:Ribonuclease_BN GD442_02330 ENOG4105C59 p-type ATPase GD442_02335 ENOG4108IPJ Membrane GD442_02345 ENOG4105C3F Signal peptidase i GD442_02355 ENOG4107ZTW SNARE associated Golgi GD442_02370 ENOG410606W general stress protein GD442_02375 ENOG4105UPD Calcium Proton GD442_02410 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GD442_02415 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GD442_02425 ENOG4108JUB Transcriptional regulator GD442_02435 ENOG4108IQI permease GD442_02470 ENOG4108A04 Beta-lactamase GD442_02485 ENOG4105CKK Glycosyl transferase, family 2 GD442_02490 ENOG4107QQG Dehydrogenase GD442_02495 ENOG4105C3I Nad-dependent epimerase dehydratase GD442_02515 ENOG4105F1A Pyruvate formate-lyase GD442_02520 ENOG4108QBV Monogalactosyldiacylglycerol synthase GD442_02535 ENOG4105CI2 imidazolone-5-propionate hydrolase GD442_02540 ENOG4105ECP epimerase GD442_02570 ENOG41067AE Membrane-bound metal-dependent hydrolase GD442_02575 ENOG4105CEN a g-specific adenine glycosylase GD442_02580 ENOG4106BXE GD442_02600 ENOG4105BZ1 (ABC) transporter GD442_02605 ENOG4107NBY Membrane GD442_02610 ENOG4105CBC glutamate synthase GD442_02620 ENOG4108IUW ABC transporter GD442_02640 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_02645 ENOG4105G5W regulator Fur family GD442_02755 ENOG4105CDY transcriptional regulatory protein GD442_02765 ENOG4108JQC penicillin-binding protein 1A GD442_02770 ENOG4108R9S DSBA oxidoreductase GD442_02780 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GD442_02790 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GD442_02795 ENOG4105BZU Histidine kinase GD442_02800 ENOG4105CYN Serine protein kinase GD442_02805 ENOG4106AKX UPF0229 protein GD442_02820 ENOG4105C94 Transporter GD442_02835 ENOG4105DZ6 Band 7 protein GD442_02845 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GD442_02850 ENOG4108V9W transcriptional regulatory protein GD442_02855 ENOG4105D4T Citrate transporter GD442_02880 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GD442_02885 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GD442_02890 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GD442_02895 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GD442_02900 ENOG4105BZ7 extracellular solute-binding protein family 1 GD442_02905 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GD442_02910 ENOG4108STX response regulator GD442_02915 ENOG4105US7 Histidine kinase GD442_02940 ENOG4108MRH transcriptional regulatory protein GD442_02950 ENOG4105C6K Malic enzyme GD442_02960 ENOG4108UZ3 Transporter GD442_02965 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD442_02975 ENOG4105BZU Histidine kinase GD442_02990 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GD442_02995 ENOG4108JB9 formate dehydrogenase GD442_03015 ENOG4105CUB amino acid GD442_03030 ENOG4105C59 p-type ATPase GD442_03035 ENOG4105DAP Nicotinate phosphoribosyltransferase GD442_03070 ENOG41073R8 VanW family GD442_03075 ENOG4108KGH TRANSCRIPTIONal GD442_03080 ENOG4105D9N nucleoside GD442_03085 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GD442_03090 ENOG4105C37 (CBS) domain GD442_03095 ENOG4108IJ0 Aspartate ammonia-lyase GD442_03100 ENOG4105DAA L-lactate GD442_03115 ENOG4105DUX Transporter GD442_03120 ENOG4108MES Periplasmic binding protein GD442_03125 ENOG4105DQ5 transport system permease protein GD442_03130 ENOG4108IHU transport system permease protein GD442_03135 ENOG4105E0A ABC, transporter GD442_03145 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GD442_03150 ENOG4105EXW epimerase dehydratase GD442_03160 ENOG4107T89 von Willebrand factor, type A GD442_03165 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GD442_03170 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GD442_03180 ENOG4105BZU Histidine kinase GD442_03185 ENOG4105D5Q Arginine ornithine antiporter GD442_03190 ENOG4107414 GntR family transcriptional regulator GD442_03195 ENOG4105C5Y PTS System GD442_03200 ENOG4105CG3 alpha amylase, catalytic region GD442_03215 ENOG4105E1K spore germination protein GD442_03225 ENOG4105CRN Aminoglycoside phosphotransferase GD442_03230 ENOG4105BZG amino acid carrier protein GD442_03235 ENOG4105CDA abc transporter atp-binding protein GD442_03240 ENOG4105CT1 (ABC) transporter GD442_03245 ENOG4105EAD ABC transporter GD442_03250 ENOG4105DRP amino acid AbC transporter GD442_03255 ENOG4108IQI permease GD442_03280 ENOG4105D29 Helix-turn-helix type 11 domain protein GD442_03285 ENOG4105NAE bifunctional deaminase-reductase domain protein GD442_03290 ENOG4105BZU Histidine kinase GD442_03305 ENOG4105CHH sulfate transporter GD442_03310 ENOG41068KF Universal stress protein GD442_03320 ENOG4105CXY transporter GD442_03325 ENOG41067TZ transcriptional regulator, MarR family GD442_03330 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_03335 ENOG4105ETE Transcriptional regulator (LacI family GD442_03340 ENOG4108RVA ribokinase GD442_03350 ENOG4105C2J ABC transporter GD442_03355 ENOG4105CNN ABC, transporter GD442_03360 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GD442_03365 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GD442_03395 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) GD442_03425 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GD442_03430 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GD442_03435 ENOG41069ER domain protein GD442_03440 ENOG4105VZ8 Transcriptional regulator GD442_03460 ENOG4105DUX Transporter GD442_03480 ENOG4105C85 amino acid GD442_03485 ENOG4105C7N Xanthine uracil vitamin C permease GD442_03495 ENOG4105D7V transposase GD442_03510 ENOG4105MA6 gCN5-related N-acetyltransferase GD442_03535 ENOG4105BZ9 Cytochrome C oxidase, subunit I GD442_03540 ENOG4105E2S oxidase) subunit II GD442_03560 ENOG4106CAD Protein of unknown function (DUF3311) GD442_03565 ENOG4105E1V na solute symporter GD442_03580 ENOG4108NHD germination protein GD442_03585 ENOG4105CE1 Ferrous iron transport protein b GD442_03590 ENOG4105CE1 Ferrous iron transport protein b GD442_03595 ENOG4105CE1 Ferrous iron transport protein b GD442_03600 ENOG4105CVA phosphate GD442_03605 ENOG4105C8U phosphate abc transporter GD442_03610 ENOG4105E2Z phosphate ABC transporter (Permease GD442_03740 ENOG41080XQ Signal transduction protein with cbs domains GD442_03760 ENOG4105ETU transcriptional activator (TenA GD442_03770 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GD442_03780 ENOG4108VEU Thiamine monophosphate synthase GD442_03785 ENOG41080HI glycine oxidase GD442_03800 ENOG4105D06 uba thif-type nad fad binding protein GD442_03805 ENOG4105DWF phosphomethylpyrimidine kinase GD442_03840 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GD442_03855 ENOG4108INS Transcriptional regulator GD442_03880 ENOG4105C19 ABC transporter GD442_03895 ENOG4105CNN ABC, transporter GD442_03910 ENOG4105C7N Xanthine uracil vitamin C permease GD442_03920 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GD442_03940 ENOG4105C5Y PTS System GD442_03955 ENOG4105K63 Thioredoxin GD442_03975 ENOG4108B31 Spore germination protein GD442_03995 ENOG4107Y03 Nitroreductase GD442_04000 ENOG4105ED1 spovr family GD442_04010 ENOG4105J4Q Transcriptional regulator GD442_04025 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GD442_04030 ENOG4105XTG Pfam:DUF156 GD442_04035 ENOG4105VFE sira family GD442_04040 ENOG4107TPS domain protein GD442_04045 ENOG4105VFE sira family GD442_04050 ENOG4105VFE sira family GD442_04055 ENOG41085GJ domain protein GD442_04060 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GD442_04065 ENOG41087NI Sulfite exporter TauE/SafE GD442_04075 ENOG4108KGH TRANSCRIPTIONal GD442_04100 ENOG4105EMD TRANSCRIPTIONal GD442_04105 ENOG4105VCP PTS System GD442_04110 ENOG4105VZJ PTS System GD442_04135 ENOG41069ER domain protein GD442_04140 ENOG4107RBB ABC transporter, permease GD442_04145 ENOG4105C19 ABC transporter GD442_04175 ENOG4105WEF catalase GD442_04210 ENOG4107T5V SNARE associated Golgi GD442_04240 ENOG4105CUB amino acid GD442_04245 ENOG4107RWR Sodium hydrogen exchanger GD442_04255 ENOG4106KNT transcriptional regulator GD442_04260 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GD442_04295 ENOG4108YXU transcriptional regulator AsnC family GD442_04300 ENOG4105CH7 arginosuccinase GD442_04305 ENOG4108IXY short-chain dehydrogenase reductase GD442_04315 ENOG4105KPY Small multidrug resistance protein GD442_04375 ENOG4107RKG DJ-1/PfpI family GD442_04380 ENOG4105CH6 catalase GD442_04390 ENOG4105D5Q Arginine ornithine antiporter GD442_04395 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GD442_04405 ENOG4105C26 Dehydrogenase GD442_04410 ENOG4105BZ1 (ABC) transporter GD442_04415 ENOG4105BZ1 (ABC) transporter GD442_04425 ENOG4105DRP amino acid AbC transporter GD442_04430 ENOG4105CDA abc transporter atp-binding protein GD442_04445 ENOG410839P GD442_04455 ENOG4108UH6 UPF0754 membrane protein GD442_04480 ENOG4107FQX Alpha-acetolactate decarboxylase GD442_04485 ENOG4108VX5 3-methyladenine DNA glycosylase GD442_04500 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GD442_04505 ENOG4105D4P Coproporphyrinogen iii oxidase GD442_04510 ENOG4105CEY Amp-dependent synthetase and ligase GD442_04525 ENOG4105CHH sulfate transporter GD442_04550 ENOG4105CGU Enoyl-CoA hydratase GD442_04570 ENOG4105DER m42 family GD442_04590 ENOG4105CTU Proline racemase GD442_04595 ENOG4105CIF Ornithine Cyclodeaminase GD442_04610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD442_04620 ENOG4108JQ7 (ABC) transporter GD442_04685 ENOG4108IBT Inherit from COG: transposase GD442_04730 ENOG4105CSH Transporter GD442_04740 ENOG4108MRH transcriptional regulatory protein GD442_04785 ENOG4105CDU Replicative dna helicase GD442_04805 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_04820 ENOG4105D9U N-acetyltransferase GD442_04840 ENOG4105F6J Alpha beta hydrolase fold GD442_04880 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GD442_04900 ENOG4105CMT Dihydroxyacetone kinase GD442_04910 ENOG4105CMT Dihydroxyacetone kinase GD442_04940 ENOG41069ER domain protein GD442_04975 ENOG4108WC5 Alpha Beta Hydrolase Fold protein GD442_05015 ENOG4105WN5 stage II sporulation protein GD442_05025 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_05035 ENOG4108MJI response regulator GD442_05040 ENOG4105BZU Histidine kinase GD442_05045 ENOG4105BZU Histidine kinase GD442_05065 ENOG4105K8R UPF0145 protein GD442_05080 ENOG4107QHE Choloylglycine hydrolase GD442_05100 ENOG4107VRP DNA repair exonuclease GD442_05105 ENOG4106D4I domain protein GD442_05135 ENOG4108MUZ hydrolase GD442_05155 ENOG4105F0F Oxalate decarboxylase GD442_05160 ENOG41067QW Transcriptional regulator GD442_05165 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GD442_05180 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GD442_05200 ENOG4105EEM helicase GD442_05210 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_05235 ENOG4105K59 histidine triad (HIT) protein GD442_05265 ENOG410905X membrane-flanked domain protein GD442_05270 ENOG4105CKV Membrane GD442_05310 ENOG410905X membrane-flanked domain protein GD442_05315 ENOG4105CKV Membrane GD442_05320 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GD442_05325 ENOG4105BZ4 penicillin-binding protein GD442_05335 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GD442_05340 ENOG4105C1Q protoporphyrinogen oxidase GD442_05365 ENOG4105NA0 Transcriptional regulator GD442_05380 ENOG4105ECB domain protein GD442_05380 ENOG4105ECB domain protein GD442_05395 ENOG4108MK9 spermidine N(1)-acetyltransferase GD442_05405 ENOG4106AXD GD442_05410 ENOG4108RQ5 Beta-lactamase domain-containing protein GD442_05415 ENOG4105DF9 Lipoate-protein, ligase GD442_05425 ENOG4105CEY Amp-dependent synthetase and ligase GD442_05435 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GD442_05440 ENOG4108I5D sulfate abc transporter GD442_05445 ENOG4105ECW sulfate abc transporter GD442_05450 ENOG4108IJ6 ABC transporter GD442_05500 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) GD442_05510 ENOG4107RN3 metallophosphoesterase GD442_05515 ENOG4107TVP HD domain protein GD442_05525 ENOG4108AEY RNA polymerase sigma factor GD442_05530 ENOG41086D8 Transcriptional regulator GD442_05540 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_05560 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GD442_05565 ENOG4105C8Q Methyl-accepting chemotaxis GD442_05570 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GD442_05580 ENOG4107QP3 malate synthase g GD442_05600 ENOG4105VEQ Cold shock protein GD442_05635 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GD442_05680 ENOG4105ERH Fumarylacetoacetate hydrolase GD442_05690 ENOG4105C8Y Acetylornithine aminotransferase GD442_05695 ENOG4106BKT UPF0344 protein GD442_05705 ENOG4105CAQ asparagine synthetase GD442_05710 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GD442_05715 ENOG4105CH6 catalase GD442_05720 ENOG4105BZU Histidine kinase GD442_05735 ENOG4108VPT UPF0234 protein GD442_05740 ENOG4105QNR S1 RNA binding domain protein GD442_05745 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_05755 ENOG4107AYK membrAne GD442_05760 ENOG41073B9 GD442_05770 ENOG4108KP7 hydrolase GD442_05780 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GD442_05805 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GD442_05810 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GD442_05825 ENOG4105C31 Tryptophanyl-tRNA synthetase GD442_05840 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GD442_05845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GD442_05855 ENOG4108JQ7 (ABC) transporter GD442_05860 ENOG4105UQX Mate efflux family protein GD442_05880 ENOG4108ZCF integral membrane protein GD442_05890 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GD442_05900 ENOG4105DPN Oligoendopeptidase f GD442_05910 ENOG4108Z18 K06886 hemoglobin GD442_05915 ENOG4105MIX Adenylate cyclase GD442_05920 ENOG4106EFP UPF0738 protein GD442_05930 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GD442_05935 ENOG4105EMS pseudouridine synthase GD442_05955 ENOG4105K64 Glycosyl transferase, family 2 GD442_05975 ENOG4107TVC Glycosyl transferase, family 2 GD442_05995 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GD442_06000 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GD442_06010 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GD442_06060 ENOG4108ZMI UPF0477 protein GD442_06085 ENOG4105CK7 Sodium proline symporter GD442_06090 ENOG4105CRQ synthase (Component I) GD442_06095 ENOG4105DDQ anthranilate synthase GD442_06100 ENOG4108I0Q anthranilate phosphoribosyltransferase GD442_06105 ENOG4105DK0 Indole-3-glycerol phosphate synthase GD442_06110 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GD442_06115 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GD442_06120 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GD442_06185 ENOG4105C7S Dehydrogenase GD442_06190 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GD442_06195 ENOG4105VZ8 Transcriptional regulator GD442_06255 ENOG4105DZ1 carboxypeptidase GD442_06260 ENOG4105VFR signal peptidase GD442_06295 ENOG4105C26 Dehydrogenase GD442_06300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GD442_06305 ENOG4105F38 ABC transporter, permease GD442_06310 ENOG4105D38 putrescine abc transporter GD442_06315 ENOG4107RUE extracellular solute-binding protein family 1 GD442_06325 ENOG4105EYF MMPL domain protein GD442_06335 ENOG4108YBP pseudouridine synthase GD442_06345 ENOG4105K4I Scp-like extracellular GD442_06350 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GD442_06355 ENOG4105CQB FAD linked oxidase domain protein GD442_06370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_06375 ENOG4105BZU Histidine kinase GD442_06380 ENOG4105JXH GntR family transcriptional regulator GD442_06400 ENOG4106A3R peptidase GD442_06410 ENOG4108QTI )-transporter GD442_06415 ENOG4107TS3 membrane protein, TerC GD442_06420 ENOG4105CZN Potassium uptake protein GD442_06425 ENOG410681C small acid-soluble spore protein GD442_06430 ENOG4108Z7G MaoC domain protein dehydratase GD442_06450 ENOG4105CHR reductase GD442_06475 ENOG4105C4Y ABC transporter GD442_06480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GD442_06485 ENOG4107RCV ABC transporter, permease GD442_06505 ENOG4105E98 transcriptional regulator DeoR family GD442_06515 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GD442_06525 ENOG4105PXI polysaccharide deacetylase GD442_06535 ENOG4105BZU Histidine kinase GD442_06540 ENOG41090MY MarR family Transcriptional regulator GD442_06550 ENOG4106DF1 GD442_06555 ENOG4105BZU Histidine kinase GD442_06560 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GD442_06565 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GD442_06570 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GD442_06605 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GD442_06625 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GD442_06630 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GD442_06635 ENOG4105CZV ABC transporter GD442_06645 ENOG4105CJ1 ABC, transporter GD442_06685 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GD442_06690 ENOG4105EA8 2-Nitropropane dioxygenase GD442_06695 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GD442_06705 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GD442_06725 ENOG4105NQC Flavodoxin GD442_06755 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GD442_06785 ENOG4105CZN Potassium uptake protein GD442_06790 ENOG41063Y9 GD442_06795 ENOG4105KBJ sporulation protein ytfj GD442_06815 ENOG4105CM2 brancheD-chain amino acid aminotransferase GD442_06820 ENOG4105C7K acetolactate synthase GD442_06825 ENOG4108ZP8 Acetolactate synthase small subunit GD442_06830 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GD442_06845 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GD442_06860 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GD442_06865 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GD442_06870 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GD442_06875 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GD442_06880 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GD442_06885 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GD442_06895 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase GD442_06900 ENOG4107RVV histidinol phosphate phosphatase, hisj family GD442_06915 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GD442_06920 ENOG4105E0M Sulfatase GD442_06930 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GD442_06945 ENOG4107S4M Sulfate adenylate transferase GD442_06950 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GD442_06955 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GD442_06965 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GD442_06970 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GD442_06975 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GD442_06980 ENOG4105C8J )-transporter GD442_07000 ENOG4105DFD Na H antiporter GD442_07020 ENOG4105ENE Histidine kinase GD442_07025 ENOG4105WH1 Two component transcriptional regulator luxr family GD442_07045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GD442_07070 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GD442_07090 ENOG4105CJ3 phosphate transporter GD442_07095 ENOG4107GRR phosphate transport regulator GD442_07100 ENOG4105BZ4 penicillin-binding protein GD442_07115 ENOG4105BZU Histidine kinase GD442_07120 ENOG4105I3N Conserved Protein GD442_07135 ENOG4105BZU Histidine kinase GD442_07140 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GD442_07165 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD442_07170 ENOG4105DZ1 carboxypeptidase GD442_07175 ENOG4108JIC nucleoside recognition domain protein GD442_07185 ENOG4105FE9 pseudouridine synthase GD442_07190 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_07195 ENOG4107TWT Cytochrome c biogenesis protein GD442_07200 ENOG4105CRE cytochrome C GD442_07205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_07210 ENOG4105BZU Histidine kinase GD442_07215 ENOG4108WBT adenosyltransferase GD442_07230 ENOG4108SAX Membrane GD442_07245 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_07250 ENOG4105I7S Abortive infection protein GD442_07260 ENOG4107RGJ metallophosphoesterase GD442_07265 ENOG4108XDN Transcriptional regulator GD442_07270 ENOG4108S6Z Negative regulator of genetic competence GD442_07295 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GD442_07300 ENOG4107RB3 L-asparaginase GD442_07315 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GD442_07330 ENOG4105S2F GD442_07335 ENOG41065D1 GD442_07365 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GD442_07380 ENOG4105XXQ heptaprenyl diphosphate synthase component I GD442_07390 ENOG4105EAH synthase GD442_07395 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GD442_07400 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GD442_07405 ENOG4105D49 3-dehydroquinate synthase GD442_07415 ENOG41068YB TPR repeat-containing protein GD442_07430 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GD442_07435 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GD442_07470 ENOG4108JYZ YitT family GD442_07475 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GD442_07480 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GD442_07490 ENOG4105FJR Lmbe family GD442_07495 ENOG4105CPK Glycosyl transferase (Group 1 GD442_07515 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GD442_07520 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GD442_07530 ENOG4105DVT helicase GD442_07535 ENOG4105YAC GD442_07555 ENOG4105CSM endonuclease III GD442_07565 ENOG4105BZ4 penicillin-binding protein GD442_07605 ENOG4106F55 Protein of unknown function (DUF1273) GD442_07620 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GD442_07630 ENOG4105DVT helicase GD442_07635 ENOG4105CTD carboxy-peptidase GD442_07645 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GD442_07650 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GD442_07655 ENOG4105C2W permease GD442_07660 ENOG4105DHF Membrane GD442_07670 ENOG410890F Dynamin family GD442_07680 ENOG4108W0I acetyltransferase GD442_07690 ENOG4105KHC sulfurtransferase GD442_07745 ENOG4105HTX biosynthesis protein GD442_07775 ENOG4105CPK Glycosyl transferase (Group 1 GD442_07790 ENOG4108SZE gCN5-related N-acetyltransferase GD442_07810 ENOG41081VK Ribonuclease GD442_07875 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GD442_07885 ENOG4107RWR Sodium hydrogen exchanger GD442_07890 ENOG4105CN5 Metallo-Beta-Lactamase GD442_07895 ENOG4108Z5V transcriptional regulator, merr family GD442_07905 ENOG4105H67 Protein of unknown function (DUF421) GD442_07910 ENOG41080C8 DUF218 domain GD442_07955 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GD442_07965 ENOG4107R0U MotA TolQ exbB proton channel GD442_07970 ENOG4105ER2 Ompa motb domain protein GD442_07975 ENOG4107YTP response regulator receiver protein GD442_07980 ENOG4105CBS Chea signal transduction histidine kinase GD442_07985 ENOG4105DD5 Flagellar motor switch protein GD442_08000 ENOG4105BZU Histidine kinase GD442_08020 ENOG4105E1Q flagellar hook-associated protein GD442_08025 ENOG4105DTJ flagellar hook-associated protein GD442_08045 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GD442_08050 ENOG4108ZC9 flagellar basal-body rod protein flgc GD442_08055 ENOG41075Z6 flagellar hook-basal body complex protein fliE GD442_08060 ENOG4107U2N Flagellar M-ring protein GD442_08065 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GD442_08095 ENOG4105BZE flagellar hook protein, FlgE GD442_08110 ENOG4107R88 Chemotaxis protein (CheV) GD442_08120 ENOG4105I03 Flagellin GD442_08125 ENOG4105I03 Flagellin GD442_08130 ENOG4105E4C Lytic transglycosylase catalytic GD442_08140 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GD442_08145 ENOG4105DD5 Flagellar motor switch protein GD442_08155 ENOG4105CN7 Flagellar biosynthetic protein FliP GD442_08160 ENOG4105VS8 Flagellar biosynthetic protein fliq GD442_08170 ENOG4105D00 flagellar biosynthetic protein flhB GD442_08175 ENOG4105D7B Flagellar biosynthesis protein flha GD442_08180 ENOG4105FZW flagellar biosynthesis regulator FlhF GD442_08185 ENOG4105KTQ flagellar basal-body rod protein GD442_08190 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GD442_08225 ENOG4105KAC Antibiotic biosynthesis monooxygenase GD442_08250 ENOG4105DUM transcriptional regulator, lysR family GD442_08265 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component GD442_08270 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GD442_08300 ENOG4105CVJ phosphoglycerate mutase GD442_08310 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GD442_08330 ENOG4105CAQ asparagine synthetase GD442_08350 ENOG4105PGM cation diffusion facilitator family transporter GD442_08360 ENOG4105DRR Transcriptional regulator, GntR family GD442_08365 ENOG4108UZ3 Transporter GD442_08375 ENOG4105CKI cobalamin synthesis protein GD442_08380 ENOG4108PJD permease GD442_08395 ENOG4105DFD Na H antiporter GD442_08400 ENOG4105VUF Transcriptional regulator GD442_08410 ENOG4105C9Q fumarate hydratase class II GD442_08425 ENOG4107QJQ Mate efflux family protein GD442_08430 ENOG4105EC3 peptidase S51, dipeptidase E GD442_08450 ENOG4107QIV Cytochrome c biogenesis protein GD442_08455 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_08465 ENOG4107JM4 Tetratricopeptide repeat GD442_08480 ENOG4105BZC d-serine deaminase GD442_08485 ENOG4106BRA Membrane GD442_08520 ENOG4105CJ1 ABC, transporter GD442_08540 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GD442_08550 ENOG4108IJ0 Aspartate ammonia-lyase GD442_08555 ENOG4105C6K Malic enzyme GD442_08605 ENOG4105FVX GD442_08620 ENOG4105CSR polyphosphate kinase 2 GD442_08625 ENOG4105U3E Transcriptional regulator GD442_08635 ENOG4105DXI Major Facilitator superfamily GD442_08645 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GD442_08650 ENOG4105EU0 Major facilitator Superfamily GD442_08655 ENOG4105C6T cysteine synthase GD442_08675 ENOG4105C8J )-transporter GD442_08685 ENOG4105X5K response regulator receiver protein GD442_08690 ENOG4105H67 Protein of unknown function (DUF421) GD442_08710 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GD442_08715 ENOG4105CHR reductase GD442_08720 ENOG4105CM2 brancheD-chain amino acid aminotransferase GD442_08725 ENOG4105C7K acetolactate synthase GD442_08735 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GD442_08740 ENOG4105C01 Dihydroxy-acid dehydratase GD442_08745 ENOG4105C7B Threonine dehydratase GD442_08770 ENOG4105C6X Major Facilitator GD442_08775 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GD442_08785 ENOG4105DY9 regulatoR GD442_08790 ENOG4105CYC Transferase GD442_08805 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GD442_08815 ENOG41068WN GD442_08820 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GD442_08835 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GD442_08840 ENOG4105C0X amino acid GD442_08885 ENOG410849A acetyltransferase, (GNAT) family GD442_08890 ENOG4105K8R UPF0145 protein GD442_08905 ENOG4107RHR regulatoR GD442_08915 ENOG4105D9N nucleoside GD442_08920 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GD442_08950 ENOG410811B TRANSCRIPTIONal GD442_08965 ENOG4107RAQ aminopeptidase GD442_08975 ENOG4107R16 Multicopper oxidase GD442_09015 ENOG4108T5E Copper resistance protein GD442_09020 ENOG4105KTB nuclear export factor GLE1 GD442_09025 ENOG4107RT3 EamA-like transporter family GD442_09030 ENOG4105GZI Transcriptional regulator GD442_09035 ENOG4108Z40 Transcriptional regulator GD442_09040 ENOG4107ZXU DSBA oxidoreductase GD442_09045 ENOG4108TVJ Nitroreductase GD442_09050 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GD442_09055 ENOG4106F5Q Membrane GD442_09060 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_09070 ENOG4105CKI cobalamin synthesis protein GD442_09080 ENOG4105C0Z ABC transporter GD442_09085 ENOG4108IV0 ABC, transporter GD442_09090 ENOG4105C32 Amino acid ABC transporter (Permease) GD442_09100 ENOG4105SKE transcriptional Regulator LysR family GD442_09110 ENOG4105MDS 4-oxalocrotonate tautomerase GD442_09130 ENOG4105C4M (Ubiquinol oxidase) subunit I GD442_09135 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GD442_09140 ENOG4108JJ9 ABC, transporter GD442_09145 ENOG4108JJ8 (ABC) transporter GD442_09155 ENOG4105K64 Glycosyl transferase, family 2 GD442_09165 ENOG4108UT6 Transferase hexapeptide repeat containing protein GD442_09220 ENOG4105BZ1 (ABC) transporter GD442_09225 ENOG4105EFI regulatoR GD442_09230 ENOG4105BZU Histidine kinase GD442_09240 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GD442_09245 ENOG4108ZJ4 polysaccharide deacetylase GD442_09265 ENOG4105D6E homoserine dehydrogenase GD442_09275 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GD442_09290 ENOG4108KGH TRANSCRIPTIONal GD442_09300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_09305 ENOG4105BZU Histidine kinase GD442_09310 ENOG4107VMI polysaccharide deacetylase GD442_09320 ENOG4105KT7 mgtC SapB transporter GD442_09325 ENOG4105VRR gCN5-related N-acetyltransferase GD442_09335 ENOG4105DUU IucA IucC family protein GD442_09340 ENOG4105CEY Amp-dependent synthetase and ligase GD442_09355 ENOG4108WBH protein TIM barrel GD442_09360 ENOG4105YWU small acid-soluble spore protein GD442_09370 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GD442_09375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD442_09425 ENOG4105KRN Transcriptional regulator, abrb family GD442_09445 ENOG4105KAF membrAne GD442_09470 ENOG4105C8Q Methyl-accepting chemotaxis GD442_09485 ENOG4108K88 Membrane GD442_09490 ENOG4108WPJ Ferritin-like domain GD442_09505 ENOG4105DEN Luciferase family GD442_09520 ENOG4105VMI -acetyltransferase GD442_09525 ENOG4107QM2 Aldo Keto reductase GD442_09530 ENOG4105CKI cobalamin synthesis protein GD442_09540 ENOG4105DSE periplasmic solute binding protein GD442_09545 ENOG4105K4T epimerase GD442_09555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GD442_09600 ENOG4107T5V SNARE associated Golgi GD442_09615 ENOG4108PJD permease GD442_09625 ENOG4108S4H thioesterase Superfamily protein GD442_09635 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GD442_09655 ENOG4105SXS Protein of unknown function (DUF456) GD442_09660 ENOG4105C37 (CBS) domain GD442_09680 ENOG4108Z7R Chaperone CsaA GD442_09700 ENOG4108ZRV stage ii sporulation protein p GD442_09710 ENOG4108VXD carboxy-peptidase GD442_09720 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GD442_09740 ENOG4108ZRV stage ii sporulation protein p GD442_09750 ENOG4108X4Q Hydrolase GD442_09755 ENOG41082F9 transcriptional regulator GD442_09760 ENOG4105D94 Major Facilitator Superfamily GD442_09770 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GD442_09780 ENOG41087PP glycosyltransferase MGT family GD442_09785 ENOG4108JYZ YitT family GD442_09790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GD442_09820 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GD442_09840 ENOG4106PAW secretion accessory protein EsaA YueB GD442_09850 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) GD442_09855 ENOG4108MGT Required for secretion of EsxA and EsxB GD442_09935 ENOG4108ZUE Phage regulatory protein rha GD442_09985 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GD442_09995 ENOG4105KBJ sporulation protein ytfj GD442_10020 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GD442_10045 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GD442_10055 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GD442_10060 ENOG4105EMN RNA polymerase sigma factor GD442_10075 ENOG4105CNW domain protein GD442_10085 ENOG4108V06 Glutathione peroxidase GD442_10100 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GD442_10110 ENOG4108IUE nitrate reductase beta subunit GD442_10115 ENOG4105R3A Nitrate reductase GD442_10125 ENOG4107V6Q Cyclic nucleotide-binding domain GD442_10130 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GD442_10135 ENOG4105D06 uba thif-type nad fad binding protein GD442_10140 ENOG4105CVM Molybdenum cofactor synthesis domain protein GD442_10145 ENOG4108ZAF Molybdopterin GD442_10175 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GD442_10180 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GD442_10185 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GD442_10190 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GD442_10195 ENOG4108IFG nitrite reductase, (NAD(P)H) GD442_10200 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GD442_10235 ENOG4105MCT stage V sporulation protein S GD442_10280 ENOG4105C5H ABC transporter GD442_10295 ENOG4108UUM single-stranded DNA-binding protein GD442_10315 ENOG4107YX5 Pfam:DUF548 GD442_10320 ENOG4105C75 arginyL-tRNA synthetase GD442_10345 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GD442_10370 ENOG4105C5S asparaginyl-tRNA synthetase GD442_10375 ENOG4105C8J )-transporter GD442_10395 ENOG4107XGZ Hydrolase GD442_10400 ENOG4105CY2 Citrate transporter GD442_10420 ENOG4105KD7 acetyltransferase GD442_10430 ENOG4105VMP Transcriptional regulator GD442_10435 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GD442_10460 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 GD442_10475 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) GD442_10480 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GD442_10490 ENOG4107RVG penicillin-binding protein GD442_10495 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GD442_10500 ENOG4105E9Q Acyl-transferase GD442_10505 ENOG4108UT2 hemolysin iii GD442_10515 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GD442_10525 ENOG4108RCR degv family GD442_10530 ENOG4107T8T UPF0173 metal-dependent hydrolase GD442_10535 ENOG4108KF3 Electron transport protein SCO1 SenC GD442_10540 ENOG4107Y70 Heat shock protein GD442_10545 ENOG4105CAQ asparagine synthetase GD442_10560 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GD442_10565 ENOG4108MES Periplasmic binding protein GD442_10570 ENOG4105F0I Aminotransferase GD442_10595 ENOG4105D8X mechanosensitive ion channel GD442_10600 ENOG4105BZU Histidine kinase GD442_10605 ENOG4105WH1 Two component transcriptional regulator luxr family GD442_10610 ENOG4106KNT transcriptional regulator GD442_10615 ENOG4107ZY0 Phenazine biosynthesis-like protein GD442_10635 ENOG4105CMG Carbohydrate kinase GD442_10640 ENOG4105C6Z Gluconate GD442_10650 ENOG4108YV3 Protein of unknown function (DUF2711) GD442_10680 ENOG4108IJ8 ABC transporter GD442_10685 ENOG4105E90 ABC transporter GD442_10720 ENOG4105C37 (CBS) domain GD442_10745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GD442_10760 ENOG4107S4Y M20 DapE family protein YgeY GD442_10765 ENOG4108TSC N-acetyltransferase GD442_10770 ENOG4108JUB Transcriptional regulator GD442_10775 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GD442_10820 ENOG410841Q phosphoesterase PA-phosphatase related protein GD442_10830 ENOG4105SZ6 Thioredoxin GD442_10880 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_10935 ENOG4105BZ4 penicillin-binding protein GD442_10945 ENOG4105CZM Major Facilitator GD442_10950 ENOG4105W8X HesB YadR YfhF-family protein GD442_10960 ENOG4105DXD 2-methylcitrate dehydratase GD442_10965 ENOG4105CR4 methylisocitrate lyase GD442_10970 ENOG4105C1G acyl-Coa dehydrogenase GD442_10975 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GD442_10985 ENOG4105N14 lysine exporter protein LysE YggA GD442_10990 ENOG4105E39 Enoyl-CoA hydratase GD442_11005 ENOG4107RFY SbcCD D subunit GD442_11010 ENOG4105EYH Exonuclease GD442_11030 ENOG4105FCD Major Facilitator GD442_11035 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GD442_11040 ENOG4105E4F Isochorismate synthase GD442_11045 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GD442_11050 ENOG4105WQI isochorismatase GD442_11055 ENOG4105CEY Amp-dependent synthetase and ligase GD442_11060 ENOG4105WQT MbtH domain protein GD442_11065 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_11080 ENOG4105K70 DNA-binding protein GD442_11100 ENOG4105BZG amino acid carrier protein GD442_11120 ENOG4105FE9 pseudouridine synthase GD442_11125 ENOG4105C22 threonyL-tRNA synthetase GD442_11130 ENOG4105C19 ABC transporter GD442_11185 ENOG41081I9 integral membrane protein GD442_11195 ENOG4108Y4K DNA-binding transcriptional activator GD442_11215 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GD442_11225 ENOG4105EYF MMPL domain protein GD442_11250 ENOG4105WCN acetyltransferase GD442_11275 ENOG4105C1Q protoporphyrinogen oxidase GD442_11285 ENOG41068WN GD442_11315 ENOG4107V2S Transcriptional regulator GD442_11320 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GD442_11340 ENOG4105DND Transcriptional regulator GD442_11345 ENOG4108RPX mosc domain containing protein GD442_11360 ENOG4105BZ1 (ABC) transporter GD442_11365 ENOG4105BZ1 (ABC) transporter GD442_11395 ENOG4108JCI Transcriptional regulator GD442_11425 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GD442_11430 ENOG4108KPJ rna polymerase sigma factor GD442_11450 ENOG4105F32 YngK protein GD442_11470 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GD442_11475 ENOG4105RD7 BadF BadG BcrA BcrD GD442_11480 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GD442_11485 ENOG4107STF Involved in phosphonate degradation (By similarity) GD442_11490 ENOG4105C7B Threonine dehydratase GD442_11495 ENOG4108INS Transcriptional regulator GD442_11515 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GD442_11530 ENOG4105C1J atp-dependent rna helicase GD442_11540 ENOG4108RZE Tetr family transcriptional regulator GD442_11645 ENOG41088CC tellurite resistance protein tehB GD442_11655 ENOG4108I0C methyltransferase GD442_11660 ENOG4107RA9 decarboxylase GD442_11665 ENOG4105K56 Transcriptional regulator GD442_11670 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GD442_11695 ENOG4105CIN aminoacyl-histidine dipeptidase GD442_11725 ENOG4105KRN Transcriptional regulator, abrb family GD442_11735 ENOG4105EJ9 Membrane GD442_11740 ENOG4105EQK -acetyltransferase GD442_11780 ENOG4105W8Z 4'-phosphopantetheinyl transferase GD442_11840 ENOG4105FQP Beta-lactamase GD442_11845 ENOG4107RVG penicillin-binding protein GD442_11860 ENOG4107RF6 penicillin-binding protein GD442_11865 ENOG4107RF6 penicillin-binding protein GD442_11885 ENOG4105CJ1 ABC, transporter GD442_11895 ENOG4107Z3H Transcriptional regulator, TetR family GD442_11910 ENOG4105C1G acyl-Coa dehydrogenase GD442_11915 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GD442_11920 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GD442_11925 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GD442_11930 ENOG4105E39 Enoyl-CoA hydratase GD442_11935 ENOG4107QX3 carboxylase GD442_11940 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GD442_11960 ENOG4105DBI uridine monophosphokinase GD442_11980 ENOG4105DZ1 carboxypeptidase GD442_11995 ENOG4105T9C HD domain GD442_12005 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GD442_12025 ENOG41075H3 AraC family transcriptional regulator GD442_12055 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GD442_12065 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GD442_12070 ENOG4105KVH Transcriptional regulator GD442_12120 ENOG4105EFA 4-hydroxyphenylacetate GD442_12135 ENOG4105CPQ Dehydrogenase GD442_12145 ENOG410900G Protein of unknown function (DUF421) GD442_12150 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GD442_12160 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GD442_12170 ENOG4105DK7 lysyl-tRNA synthetase GD442_12180 ENOG4108VQT Alpha beta hydrolase fold protein GD442_12220 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GD442_12255 ENOG4105D6E homoserine dehydrogenase GD442_12265 ENOG4105CPF Cell wall formation (By similarity) GD442_12270 ENOG4105ETU transcriptional activator (TenA GD442_12360 ENOG410667J hydrolase GD442_12365 ENOG4105BZU Histidine kinase GD442_12370 ENOG4107RF6 penicillin-binding protein GD442_12395 ENOG4108JJB ABC transporter GD442_12410 ENOG4108HGU Histidine kinase GD442_12425 ENOG4105CB2 alcohol dehydrogenase GD442_12430 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GD442_12435 ENOG4105CJN penicillin-binding protein GD442_12480 ENOG4107Y80 Major Facilitator superfamily GD442_12485 ENOG4108Z5V transcriptional regulator, merr family GD442_12505 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GD442_12530 ENOG4107Y9U Membrane GD442_12570 ENOG4105FCD Major Facilitator GD442_12580 ENOG4105E09 nadh pyrophosphatase GD442_12585 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GD442_12605 ENOG4108XI2 Domain of unknown function (DUF1963) GD442_12625 ENOG4108NRW Phospholipase, patatin family GD442_12630 ENOG4105KWG Pfam:DUF1696 GD442_12640 ENOG4108YYS metal-dependent hydrolase (By similarity) GD442_12655 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GD442_12665 ENOG4105PKS Excinuclease abc c subunit domain protein GD442_12705 ENOG4107VFR oxidoreductase GD442_12735 ENOG4105U0R haloacid dehalogenase-like hydrolase GD442_12740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_12745 ENOG4105BZU Histidine kinase GD442_12765 ENOG4107WD8 ABC transporter, permease GD442_12780 ENOG4108IUM Glycogen debranching enzyme GD442_12790 ENOG4105CGH 5'-nucleotidase GD442_12805 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GD442_12810 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GD442_12815 ENOG4105FDR Membrane GD442_12825 ENOG4105CIS alcohol dehydrogenase GD442_12830 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GD442_12875 ENOG4105MSI germination protein ypeb GD442_12905 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GD442_12910 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GD442_12915 ENOG4107Z3H Transcriptional regulator, TetR family GD442_12935 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GD442_12950 ENOG4105E98 transcriptional regulator DeoR family GD442_12965 ENOG41062ES Transcriptional regulator GD442_12985 ENOG4107QKR Dehydrogenase GD442_12995 ENOG4107RUY (E1 component), alpha subunit GD442_13005 ENOG4105E1F short-chain dehydrogenase reductase GD442_13010 ENOG4105RHY Pfam:UPF0157 GD442_13050 ENOG4107SQ8 Glycine betaine GD442_13055 ENOG4108IJ7 Glycine betaine GD442_13065 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GD442_13080 ENOG4105E66 phosphoriboisomerase A GD442_13085 ENOG41082BV acetyltransferase GD442_13090 ENOG4108M1A Chitin-binding protein GD442_13120 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_13125 ENOG4105MSB protein, conserved in bacteria GD442_13145 ENOG4108Z7F N-acetyltransferase GD442_13165 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GD442_13170 ENOG4105EEM helicase GD442_13185 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_13230 ENOG4108M1A Chitin-binding protein GD442_13250 ENOG4105BZG amino acid carrier protein GD442_13255 ENOG4105C26 Dehydrogenase GD442_13260 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GD442_13265 ENOG4105CTU Proline racemase GD442_13270 ENOG4105CTU Proline racemase GD442_13275 ENOG41080HI glycine oxidase GD442_13285 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GD442_13315 ENOG4107T5V SNARE associated Golgi GD442_13325 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GD442_13345 ENOG4105DTQ mandelate racemase muconate lactonizing GD442_13360 ENOG4107SET aldo keto reductase GD442_13395 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GD442_13400 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GD442_13405 ENOG4105BZU Histidine kinase GD442_13410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_13435 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GD442_13450 ENOG4105DPN Oligoendopeptidase f GD442_13455 ENOG4105EPR degv family GD442_13515 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GD442_13520 ENOG4106K7D Major facilitator family transporter GD442_13540 ENOG4107BMA Transglycosylase associated protein GD442_13555 ENOG41089UC methyltransferase, type 11 GD442_13590 ENOG4105CHM Aminotransferase GD442_13620 ENOG4105DVE abc transporter atp-binding protein GD442_13670 ENOG4105C02 permease GD442_13680 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GD442_13685 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GD442_13690 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GD442_13695 ENOG4105D7T ABC transporter GD442_13730 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GD442_13765 ENOG4107VC0 DNA alkylation repair enzyme GD442_13770 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_13780 ENOG4107VMI polysaccharide deacetylase GD442_13790 ENOG4108ZCF integral membrane protein GD442_13795 ENOG4105E0M Sulfatase GD442_13800 ENOG4105C5H ABC transporter GD442_13810 ENOG4105EYF MMPL domain protein GD442_13815 ENOG41082JN Transcriptional regulator GD442_13835 ENOG4105CIH Imidazole acetol-phosphate transaminase GD442_13840 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GD442_13845 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GD442_13890 ENOG41069ER domain protein GD442_13900 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_13930 ENOG4105D4B ABC, transporter GD442_13935 ENOG4105F5R ABC transporter GD442_13940 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GD442_13950 ENOG4105DKT Transcriptional regulator GD442_13955 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) GD442_13965 ENOG41061GT Aldolase GD442_13975 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GD442_14010 ENOG4105II7 pyrroline-5-carboxylate reductase GD442_14020 ENOG4107258 Transcriptional regulator GD442_14035 ENOG4105ECK Fatty Acid Desaturase GD442_14045 ENOG4107RBI VanW family GD442_14050 ENOG4105G6Z alkaline phosphatase GD442_14060 ENOG4105VMP Transcriptional regulator GD442_14080 ENOG41068WN GD442_14110 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GD442_14135 ENOG4105CKK Glycosyl transferase, family 2 GD442_14165 ENOG4105C8Y Acetylornithine aminotransferase GD442_14210 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GD442_14255 ENOG4108IBT Inherit from COG: transposase GD442_14275 ENOG4108TVJ Nitroreductase GD442_14280 ENOG4105FS7 Transcriptional regulator GD442_14295 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GD442_14300 ENOG4105WEC Molybdate metabolism regulator GD442_14310 ENOG4105CMR udp-glucose 4-epimerase GD442_14320 ENOG4108DMH HTH_ARAC GD442_14325 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GD442_14330 ENOG4108XET gCN5-related N-acetyltransferase GD442_14345 ENOG4108PCN EamA-like transporter family GD442_14365 ENOG4107XJU UPF0178 protein GD442_14405 ENOG410635A Membrane GD442_14415 ENOG4108IQI permease GD442_14425 ENOG4105F1N DNA alkylation repair GD442_14460 ENOG4107RF6 penicillin-binding protein GD442_14465 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GD442_14490 ENOG4105E7W lamb ycsf family protein GD442_14500 ENOG4105P4J Allophanate hydrolase, subunit 1 GD442_14505 ENOG4107258 Transcriptional regulator GD442_14515 ENOG4106N3A copper homeostasis protein cutc GD442_14520 ENOG4108ZHR arsR family transcriptional regulator GD442_14530 ENOG4105FDT acyl-CoA dehydrogenase GD442_14545 ENOG4105DWD nucleoside recognition domain protein GD442_14590 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GD442_14615 ENOG4105E2A Dehydrogenase GD442_14620 ENOG4108IJ0 Aspartate ammonia-lyase GD442_14625 ENOG4105HDK L-asparaginase GD442_14630 ENOG4108IMY Transcriptional regulator GD442_14655 ENOG4108B31 Spore germination protein GD442_14665 ENOG4105BZU Histidine kinase GD442_14690 ENOG41075H3 AraC family transcriptional regulator GD442_14705 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GD442_14710 ENOG4105CUB amino acid GD442_14715 ENOG4105II7 pyrroline-5-carboxylate reductase GD442_14720 ENOG4108NHD germination protein GD442_14725 ENOG4108Q8B Spore germination protein GD442_14760 ENOG4106A3M Cytochrome p-450 GD442_14775 ENOG4105CGH 5'-nucleotidase GD442_14785 ENOG4105CHJ isochorismatase hydrolase GD442_14810 ENOG41090MY MarR family Transcriptional regulator GD442_14835 ENOG4105F6J Alpha beta hydrolase fold GD442_14850 ENOG4108606 TspO/MBR family GD442_14855 ENOG4105CVP deoxyribo-dipyrimidine photolyase GD442_14880 ENOG4108TWJ NADH dehydrogenase subunit 5 GD442_14885 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GD442_14900 ENOG4105E1K spore germination protein GD442_14905 ENOG4107VMI polysaccharide deacetylase GD442_14910 ENOG4105KY5 gCN5-related N-acetyltransferase GD442_14915 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GD442_14925 ENOG4105Z7P Acetyltransferase (GNAT) family GD442_14935 ENOG4105D6J arsenicaL-resistance protein GD442_14940 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_14945 ENOG41085FC arsR family transcriptional regulator GD442_14955 ENOG4105NAE bifunctional deaminase-reductase domain protein GD442_14960 ENOG4107P5I polyketide synthase GD442_14965 ENOG4108IG5 Transcriptional regulator GD442_14970 ENOG4105F27 Major Facilitator GD442_14975 ENOG4105M4P Tetr family transcriptional regulator GD442_14980 ENOG4105CHR reductase GD442_14985 ENOG4108YXU transcriptional regulator AsnC family GD442_15075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_15080 ENOG41062D9 Histidine kinase GD442_15120 ENOG4105C19 ABC transporter GD442_15150 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GD442_15155 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_15170 ENOG4105K6H D-cysteine desulfhydrase GD442_15185 ENOG4105JQZ Methyltransferase GD442_15200 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GD442_15220 ENOG4105BZU Histidine kinase GD442_15230 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GD442_15240 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GD442_15285 ENOG4105C44 Serine transporter GD442_15290 ENOG4105EJQ L-serine dehydratase GD442_15305 ENOG4108JPW Aminotransferase GD442_15320 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GD442_15330 ENOG4105DVH amino acid GD442_15345 ENOG4108JQ1 Dehydrogenase GD442_15350 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GD442_15365 ENOG41082W1 Cupin 2, conserved barrel domain protein GD442_15370 ENOG410874W AraC family transcriptional regulator GD442_15390 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GD442_15500 ENOG4108VXD carboxy-peptidase GD442_15505 ENOG4105PNM synthesis protein GD442_15515 ENOG4108ISG Major Facilitator GD442_15530 ENOG4107MII Sugar-specific transcriptional regulator TrmB GD442_15535 ENOG4105CZM Major Facilitator GD442_15545 ENOG4105CRW Short chain fatty acid transporter GD442_15555 ENOG4105DYS nad(p)h dehydrogenase (quinone) GD442_15615 ENOG4108K8S endonuclease I GD442_15630 ENOG4108Z66 YbaK ebsC protein GD442_15635 ENOG4105CUT histidyl-tRNA synthetase GD442_15650 ENOG4105KVH Transcriptional regulator GD442_15655 ENOG4108RCM Nitroreductase GD442_15685 ENOG4108PSK reductase GD442_15750 ENOG4105C31 Tryptophanyl-tRNA synthetase GD442_15755 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GD442_15785 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GD442_15795 ENOG4105EV4 Multidrug resistance protein mdtH GD442_15825 ENOG4105C37 (CBS) domain GD442_15840 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GD442_15845 ENOG4105FAW cDP-glucose 4,6-dehydratase GD442_15880 ENOG4105DDN Pentapeptide repeat-containing protein GD442_15885 ENOG4105XDF Protein of unknown function (DUF1272) GD442_15890 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GD442_15895 ENOG4105CMG Carbohydrate kinase GD442_15900 ENOG4105C6Z Gluconate GD442_15915 ENOG4105CV1 Transketolase (EC 2.2.1.1) GD442_15920 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GD442_15930 ENOG4105CIS alcohol dehydrogenase GD442_15935 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GD442_15945 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GD442_15960 ENOG4105C8Q Methyl-accepting chemotaxis GD442_15965 ENOG4108UX3 '-nucleotidase GD442_15970 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GD442_15975 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GD442_15980 ENOG4105KVH Transcriptional regulator GD442_15995 ENOG4105CV8 reductase GD442_16000 ENOG4105F27 Major Facilitator GD442_16010 ENOG41090KN UPF0303 protein GD442_16025 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GD442_16030 ENOG4105CHH sulfate transporter GD442_16045 ENOG4105C44 Serine transporter GD442_16075 ENOG4105KVH Transcriptional regulator GD442_16080 ENOG4108TZY GntR Family Transcriptional Regulator GD442_16085 ENOG4105D9R oxidoreductase GD442_16090 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GD442_16095 ENOG4105KVH Transcriptional regulator GD442_16100 ENOG4105KVH Transcriptional regulator GD442_16145 ENOG4105JAB phenazine biosynthesis protein, phzf family GD442_16155 ENOG4108RU0 short-chain dehydrogenase reductase GD442_16170 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GD442_16175 ENOG4105KVH Transcriptional regulator GD442_16185 ENOG4108ZJ4 polysaccharide deacetylase GD442_16240 ENOG4105KAF membrAne GD442_16265 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GD442_16275 ENOG4107YXZ hydrolase, family 25 GD442_16310 ENOG4105H3G oxidoreductase GD442_16375 ENOG4108TN2 lmbE family GD442_16385 ENOG4107R3E Citrate transporter GD442_16400 ENOG4108MES Periplasmic binding protein GD442_16405 ENOG4105EHG Permease protein GD442_16410 ENOG4105DQ5 transport system permease protein GD442_16415 ENOG4105NX3 Membrane GD442_16435 ENOG41068WN GD442_16440 ENOG4107CUJ Protein of unknown function (DUF2690) GD442_16450 ENOG4107V2S Transcriptional regulator GD442_16470 ENOG4105C98 muts2 protein GD442_16480 ENOG4105E5K Alpha-amylase GD442_16485 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GD442_16490 ENOG4105DPN Oligoendopeptidase f GD442_16510 ENOG4105FFC UPF0187 protein GD442_16525 ENOG4108A04 Beta-lactamase GD442_16550 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GD442_16560 ENOG41082BM Transcriptional regulator, arsr family GD442_16565 ENOG4105CIS alcohol dehydrogenase GD442_16590 ENOG4105CQB FAD linked oxidase domain protein GD442_16615 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GD442_16620 ENOG4107TPS domain protein GD442_16625 ENOG4105CEP NADH dehydrogenase GD442_16635 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GD442_16645 ENOG4108IAJ Nad-dependent epimerase dehydratase GD442_16650 ENOG4105FAW cDP-glucose 4,6-dehydratase GD442_16695 ENOG4105BZU Histidine kinase GD442_16700 ENOG4105C5H ABC transporter GD442_16725 ENOG4105BZU Histidine kinase GD442_16735 ENOG4105KT7 mgtC SapB transporter GD442_16745 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_16750 ENOG41073R8 VanW family GD442_16760 ENOG4108R1P GD442_16775 ENOG4105VEQ Cold shock protein GD442_16815 ENOG410904N short-chain dehydrogenase reductase GD442_16825 ENOG4106IQC argininosuccinate lyase GD442_16840 ENOG4108IA2 Sodium pantothenate symporter GD442_16850 ENOG4105C26 Dehydrogenase GD442_16855 ENOG4105CHR reductase GD442_16865 ENOG4105EWU Squalene--hopene cyclase GD442_16875 ENOG4105FR1 rard protein GD442_16880 ENOG410696E Membrane GD442_16895 ENOG4105D1F ATP-binding protein GD442_16905 ENOG4108ZAF Molybdopterin GD442_16910 ENOG4105CVM Molybdenum cofactor synthesis domain protein GD442_16915 ENOG4105D06 uba thif-type nad fad binding protein GD442_16920 ENOG4105TMB Formate nitrite transporter GD442_16930 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GD442_16935 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GD442_16945 ENOG4108JB9 formate dehydrogenase GD442_16950 ENOG4105E1K spore germination protein GD442_16965 ENOG4105CUB amino acid GD442_17020 ENOG4107QJT sodium dicarboxylate symporter GD442_17025 ENOG4108KGH TRANSCRIPTIONal GD442_17035 ENOG4105EMN RNA polymerase sigma factor GD442_17045 ENOG4105CIG ABC transporter GD442_17065 ENOG4105D9R oxidoreductase GD442_17075 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GD442_17080 ENOG4105K4P CoA-binding domain protein GD442_17085 ENOG4105C0H protease GD442_17090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_17100 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GD442_17105 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GD442_17110 ENOG4105W8X HesB YadR YfhF-family protein GD442_17140 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GD442_17145 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GD442_17155 ENOG4108JJA ABC, transporter GD442_17160 ENOG4108I0Z Aconitate hydratase GD442_17190 ENOG4105E5W Transporter GD442_17200 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GD442_17220 ENOG4107F3J Amp-dependent synthetase and ligase GD442_17225 ENOG4107ZYJ bioY protein GD442_17230 ENOG4105CEY Amp-dependent synthetase and ligase GD442_17275 ENOG4107AYK membrAne GD442_17285 ENOG4105BZU Histidine kinase GD442_17290 ENOG4105FBA Phospholipase Carboxylesterase GD442_17295 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GD442_17300 ENOG4105CK7 Sodium proline symporter GD442_17310 ENOG4105CBC glutamate synthase GD442_17315 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GD442_17320 ENOG4108VJ1 Transcriptional regulator (CarD family GD442_17325 ENOG4108903 Formimidoylglutamase GD442_17380 ENOG4107QIV Cytochrome c biogenesis protein GD442_17390 ENOG4105CH2 amidohydrolase GD442_17400 ENOG4105CJ1 ABC, transporter GD442_17415 ENOG4107RSM transcriptional regulator GD442_17420 ENOG4105VAW lrga family GD442_17425 ENOG41067MG lrgb family GD442_17465 ENOG4105BZ1 (ABC) transporter GD442_17470 ENOG4105BZ1 (ABC) transporter GD442_17505 ENOG4108HW3 (ABC) transporter GD442_17510 ENOG4105CGH 5'-nucleotidase GD442_17520 ENOG4108SVB resolvase GD442_17540 ENOG4105K7K Transcriptional regulator GD442_17545 ENOG4105C5F glutamine synthetase GD442_17550 ENOG4105KV4 Transcriptional regulator GD442_17555 ENOG4105CXI aluminum resistance protein GD442_17560 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GD442_17565 ENOG4105EN6 Membrane GD442_17570 ENOG4106F1P AAA ATPase, central domain protein GD442_17600 ENOG41069ER domain protein GD442_17605 ENOG4105DM4 PTS System GD442_17610 ENOG4105DE4 1-phosphofructokinase GD442_17615 ENOG4105E98 transcriptional regulator DeoR family GD442_17620 ENOG4107QW4 alcohol dehydrogenase GD442_17625 ENOG4108SJC Membrane GD442_17635 ENOG4105C85 amino acid GD442_17650 ENOG4105TMB Formate nitrite transporter GD442_17655 ENOG4105K70 DNA-binding protein GD442_17665 ENOG4105C59 p-type ATPase GD442_17670 ENOG410681U heavy metal transport detoxification protein GD442_17675 ENOG4105VPX protein, conserved in bacteria GD442_17685 ENOG4105NIV Esterase GD442_17690 ENOG4105E0A ABC, transporter GD442_17710 ENOG4105CGK Exodeoxyribonuclease III GD442_17720 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GD442_17725 ENOG4105D03 DNA-3-methyladenine glycosylase II GD442_17730 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GD442_17750 ENOG4105BZU Histidine kinase GD442_17790 ENOG41067MG lrgb family GD442_17810 ENOG4108S3Y transcriptional regulator GD442_17815 ENOG4105CS2 ec 3.2.1.21 GD442_17830 ENOG4105F0V Cell wall hydrolase GD442_17840 ENOG4105E0M Sulfatase GD442_17845 ENOG410890F Dynamin family GD442_17880 ENOG4105DQU oxidoreductase, subunit beta GD442_17885 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GD442_17890 ENOG4108IGT Dipeptidase GD442_17895 ENOG4105MCT stage V sporulation protein S GD442_17900 ENOG4105D48 metallophosphoesterase GD442_17915 ENOG4105CEV competence damage-inducible protein GD442_17920 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GD442_17935 ENOG4105XZV Protein of unknown function (DUF3243) GD442_17940 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GD442_17960 ENOG4105UIB (ABC) transporter GD442_17965 ENOG4108JQ9 ABC transporter GD442_17970 ENOG4105DIH basic membrane GD442_17975 ENOG4105FDP GntR family transcriptional regulator GD442_17980 ENOG4105CNU cell division protein FtsK GD442_17990 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GD442_18000 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GD442_18010 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GD442_18015 ENOG4108S0H Dipicolinic acid synthetase, b subunit GD442_18035 ENOG4108IBT Inherit from COG: transposase GD442_18210 ENOG4105CDU Replicative dna helicase GD442_18250 ENOG4108IMY Transcriptional regulator GD442_18280 ENOG4105E35 Dipicolinate synthase subunit A GD442_18290 ENOG4105C1V Peptidase, M16 GD442_18310 ENOG4105DTN riboflavin biosynthesis protein ribF GD442_18325 ENOG4105W7A Protein of unknown function (DUF503) GD442_18335 ENOG4105VHM ribosomal protein GD442_18340 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GD442_18345 ENOG4105CHV Transcription elongation factor NusA GD442_18355 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GD442_18365 ENOG4105DZP Membrane-associated zinc metalloprotease GD442_18370 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GD442_18375 ENOG4105KNE Phosphatidate cytidylyltransferase GD442_18380 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GD442_18390 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GD442_18420 ENOG4108HE4 integrase family GD442_18425 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GD442_18430 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GD442_18435 ENOG4105C79 DNA protecting protein DprA GD442_18440 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GD442_18455 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GD442_18480 ENOG4105VB6 UPF0109 protein GD442_18500 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GD442_18505 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GD442_18520 ENOG4105CHR reductase GD442_18525 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GD442_18540 ENOG4105CB5 ATP-dependent DNA helicase recG GD442_18545 ENOG4105DP4 dak2 domain fusion protein ylov GD442_18550 ENOG4108ZAA Alkaline-shock protein GD442_18565 ENOG4105FJ0 thiamine GD442_18570 ENOG4105DJV ribulose-phosphate 3-epimerase GD442_18575 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GD442_18580 ENOG4105D9P serine threonine protein kinase GD442_18585 ENOG4108ZF3 Phosphatase GD442_18590 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GD442_18595 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GD442_18610 ENOG4105C25 Primosomal protein n' GD442_18615 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GD442_18635 ENOG4105DSJ YicC domain protein GD442_18645 ENOG4105F23 Fibronectin-binding protein GD442_18650 ENOG4105DC7 peptidase M24 GD442_18670 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GD442_18685 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GD442_18690 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GD442_18700 ENOG4105CD3 dihydroorotase GD442_18720 ENOG4105C34 Pseudouridine synthase GD442_18735 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GD442_18745 ENOG4105DBK s4 domain protein GD442_18750 ENOG41067XK integral membrane protein GD442_18760 ENOG4105DFA alanine racemase domain protein GD442_18765 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GD442_18770 ENOG4105WR5 sporulation protein, YlmC YmxH family GD442_18780 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_18790 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GD442_18795 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GD442_18805 ENOG4105D4A Cell wall formation (By similarity) GD442_18810 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GD442_18815 ENOG4105CNI cell division protein FtsW GD442_18820 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GD442_18830 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GD442_18835 ENOG4105CJN penicillin-binding protein GD442_18840 ENOG4105CJN penicillin-binding protein GD442_18855 ENOG41074B2 UPF0747 protein GD442_18880 ENOG4105KNH Nucleic acid-binding protein GD442_18890 ENOG41063PX domain protein GD442_18895 ENOG4105D78 K07001 NTE family protein GD442_18900 ENOG4105H20 Sporulation integral membrane protein YlbJ GD442_18910 ENOG4106H78 methyltransferase GD442_18935 ENOG4107TB6 phosphoglycerate mutase GD442_18950 ENOG4106UY4 Inherit from COG: Scp-like extracellular GD442_18995 ENOG4107VFP cytochrome oxidase assembly GD442_19000 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GD442_19005 ENOG4105CNI cell division protein FtsW GD442_19020 ENOG4108IAB Phoh family GD442_19040 ENOG4105QA2 GD442_19045 ENOG4105CI3 gtp-binding protein typa GD442_19055 ENOG4105ECY inositol monophosphatase GD442_19075 ENOG4105CXN decarboxylase GD442_19125 ENOG4105CPP Dehydrogenase, E1 component GD442_19140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GD442_19145 ENOG4108X4Q Hydrolase GD442_19155 ENOG4105CN5 Metallo-Beta-Lactamase GD442_19160 ENOG4107ZYR domain protein GD442_19195 ENOG4108XRC Protein of unknown function (DUF458) GD442_19200 ENOG4107IN1 Protein of unknown function (DUF1797) GD442_19215 ENOG4105EPM Diguanylate phosphodiesterase GD442_19220 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GD442_19235 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GD442_19250 ENOG4105UIN GD442_19285 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GD442_19305 ENOG4108HGU Histidine kinase GD442_19315 ENOG4105CHM Aminotransferase GD442_19320 ENOG4105FKQ transcriptional regulator GD442_19325 ENOG4105EG2 ABC transporter, permease GD442_19335 ENOG4107FKK extracellular solute-binding protein family 1 GD442_19345 ENOG4105CG3 alpha amylase, catalytic region GD442_19390 ENOG4105CHU acetyl-coa acetyltransferase GD442_19425 ENOG4105K7K Transcriptional regulator GD442_19430 ENOG4105DTD Dehydrogenase GD442_19450 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GD442_19460 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate GD442_19475 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GD442_19490 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GD442_19500 ENOG4105BZU Histidine kinase GD442_19520 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GD442_19535 ENOG4105CID antiterminator GD442_19545 ENOG4105FDP GntR family transcriptional regulator GD442_19555 ENOG4105CE4 GlcNAc 6-P deacetylase GD442_19590 ENOG4107ZE5 PPIases accelerate the folding of proteins GD442_19595 ENOG4105PTM secreted protein GD442_19600 ENOG4105J7I hydrolase GD442_19610 ENOG4105G6R Stage v sporulation protein ae GD442_19620 ENOG4105CZ3 stage V sporulation protein ad GD442_19625 ENOG41090VF Stage v sporulation protein ac GD442_19645 ENOG4105C8J )-transporter GD442_19650 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_19660 ENOG41082AN stage II sporulation protein GD442_19665 ENOG4105DZ1 carboxypeptidase GD442_19670 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GD442_19675 ENOG4105DVE abc transporter atp-binding protein GD442_19710 ENOG4105D7N magnesium and cobalt transport protein CorA GD442_19735 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GD442_19745 ENOG4105I3K Ferric uptake regulator, Fur family GD442_19750 ENOG4105MZ9 stage II sporulation protein m GD442_19770 ENOG4105CPC Aldo Keto reductase GD442_19780 ENOG4105RHY Pfam:UPF0157 GD442_19800 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GD442_19810 ENOG4105ETE Transcriptional regulator (LacI family GD442_19815 ENOG4108YM7 Gcn5-related n-acetyltransferase GD442_19835 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GD442_19840 ENOG4108R6K riboflavin synthase, subunit alpha GD442_19865 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_19870 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GD442_19880 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GD442_19885 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GD442_19895 ENOG4105DFD Na H antiporter GD442_19900 ENOG4105CGH 5'-nucleotidase GD442_19925 ENOG4105DBV ornithine carbamoyltransferase GD442_19940 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GD442_19955 ENOG4108IXY short-chain dehydrogenase reductase GD442_19960 ENOG41069FQ Metallo-beta-lactamase superfamily GD442_19965 ENOG4105II7 pyrroline-5-carboxylate reductase GD442_19970 ENOG4105EJQ L-serine dehydratase GD442_19985 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GD442_20000 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GD442_20015 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GD442_20020 ENOG4105D9U N-acetyltransferase GD442_20035 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GD442_20040 ENOG4108QEG Membrane GD442_20045 ENOG4105CDA abc transporter atp-binding protein GD442_20050 ENOG4105E5Q amino acid AbC transporter GD442_20055 ENOG4108HW3 (ABC) transporter GD442_20065 ENOG4105G7B Protein of unknown function (DUF2992) GD442_20075 ENOG4108QY0 Membrane GD442_20085 ENOG4105C7S Dehydrogenase GD442_20090 ENOG4105CPP Dehydrogenase, E1 component GD442_20105 ENOG4105CKM Branched-chain carboxylic acid kinase GD442_20110 ENOG4107RDP Dehydrogenase GD442_20120 ENOG4108JUB Transcriptional regulator GD442_20130 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GD442_20145 ENOG4107QQR Sporulation GD442_20150 ENOG4105S1Z Stage IV sporulation protein B GD442_20155 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GD442_20160 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GD442_20165 ENOG4105DX0 Hemolysin A GD442_20175 ENOG4105CTB Polyprenyl synthetase GD442_20190 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GD442_20200 ENOG4108ZSR alkaline shock protein GD442_20205 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GD442_20230 ENOG410644B Stage III sporulation protein af GD442_20240 ENOG4105KQ4 Stage iii sporulation protein ad GD442_20245 ENOG4108CQH stage III sporulation protein AC GD442_20250 ENOG4105KR5 Stage iii sporulation protein GD442_20255 ENOG4105CD2 stage iii sporulation protein aa GD442_20280 ENOG4105DC7 peptidase M24 GD442_20285 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GD442_20295 ENOG4105CBJ Metal-dependent enzyme GD442_20305 ENOG4107YBY Hydrolase GD442_20335 ENOG41082GG biotin lipoate A B protein ligase GD442_20340 ENOG4105WZW rhodanese family GD442_20365 ENOG41080TC multidrug resistance protein GD442_20395 ENOG4105CJ1 ABC, transporter GD442_20400 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GD442_20430 ENOG4105C0D helicase GD442_20510 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GD442_20515 ENOG4105XSJ toxin secretion phage lysis holin GD442_20670 ENOG4105DVF Cytosine-specific methyltransferase GD442_20720 ENOG4105KRN Transcriptional regulator, abrb family GD442_20825 ENOG4107R6U sodium dicarboxylate symporter GD442_20860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GD442_20865 ENOG4105C3R Methionine synthase GD442_20875 ENOG4105C28 cystathionine GD442_20880 ENOG4105C28 cystathionine GD442_20900 ENOG4105C5X domain protein GD442_20910 ENOG4105DKQ ROK family GD442_20920 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GD442_20940 ENOG4108UTW Plays a role in the regulation of phosphate uptake GD442_20945 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GD442_20950 ENOG4105C8U phosphate abc transporter GD442_20955 ENOG4105C8U phosphate abc transporter GD442_20960 ENOG4105EXS phosphate abc transporter GD442_20965 ENOG4107RF6 penicillin-binding protein GD442_20975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD442_21000 ENOG4105N80 Ferric uptake regulator, Fur family GD442_21010 ENOG4105FDK ABC transporter GD442_21015 ENOG4108JYZ YitT family GD442_21020 ENOG41069ZM Protein of unknown function (DUF2624) GD442_21045 ENOG4105EGD dinuclear metal center protein, YbgI family GD442_21060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_21065 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GD442_21090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GD442_21095 ENOG4105KG3 cytidine deaminase GD442_21100 ENOG4107YR5 Diacylglycerol kinase GD442_21105 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GD442_21110 ENOG4105CTJ Metal Dependent Phosphohydrolase GD442_21115 ENOG4105C9A Phoh family GD442_21125 ENOG41068P3 sporulation protein YqfC GD442_21130 ENOG4105KTH gatB Yqey GD442_21140 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GD442_21145 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GD442_21175 ENOG4105CSA Coproporphyrinogen iii oxidase GD442_21180 ENOG4105KVH Transcriptional regulator GD442_21205 ENOG4105TQK DNA polymerase iii, delta' subunit GD442_21215 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GD442_21220 ENOG4108UK2 deaminase GD442_21225 ENOG4105KQC Competence protein GD442_21235 ENOG4105DXX methyltransferase GD442_21245 ENOG4108WF2 Metal Dependent Phosphohydrolase GD442_21255 ENOG410812S Rna-binding protein GD442_21265 ENOG4105CQW ribosome biogenesis GTPase YqeH GD442_21270 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GD442_21285 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_21305 ENOG4108TVJ Nitroreductase GD442_21320 ENOG4105G6Z alkaline phosphatase GD442_21325 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GD442_21330 ENOG4108MUZ hydrolase GD442_21370 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GD442_21375 ENOG4105MIR Phenylalanine 4-monooxygenase GD442_21385 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_21425 ENOG4105S6R Iron-hydroxamate transporter permease subunit GD442_21430 ENOG4108V5C ABC transporter GD442_21440 ENOG4108EKI Dehydrogenase GD442_21445 ENOG4105C28 cystathionine GD442_21475 ENOG4107XRG penicillin-binding protein GD442_21485 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GD442_21495 ENOG4105CFP Peptidase U32 GD442_21500 ENOG4105XYU peptidase (U32 family) GD442_21505 ENOG4108VQJ O-methyltransferase GD442_21510 ENOG4105HHA aminodeoxychorismate lyase GD442_21530 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GD442_21540 ENOG4105C02 permease GD442_21555 ENOG41060CR GD442_21560 ENOG4105C7H Helicase, RecD TraA family GD442_21570 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GD442_21575 ENOG4105C3J Cysteine desulfurase GD442_21585 ENOG4105D1H recombination factor protein RarA GD442_21590 ENOG4108VCI transcription factor, rsfa family GD442_21595 ENOG4105CUZ uba thif-type nad fad binding protein GD442_21605 ENOG4105CUT histidyl-tRNA synthetase GD442_21610 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GD442_21615 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GD442_21625 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GD442_21630 ENOG41076HS cation diffusion facilitator family transporter GD442_21635 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GD442_21645 ENOG4105CKP Polysaccharide Biosynthesis Protein GD442_21650 ENOG4108QG2 Membrane GD442_21660 ENOG4105VIE preprotein translocase, subunit YajC GD442_21675 ENOG41061AI Protein of unknown function (DUF2905) GD442_21690 ENOG4108HUF Transporter GD442_21715 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GD442_21720 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GD442_21725 ENOG4108IYU L-aspartate oxidase GD442_21740 ENOG4108RPX mosc domain containing protein GD442_21745 ENOG4105CQC Prephenate dehydratase GD442_21760 ENOG4105C19 ABC transporter GD442_21765 ENOG4105EWM Histidine kinase GD442_21775 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GD442_21795 ENOG4105C03 ribonuclease GD442_21810 ENOG4107QMS site-determining protein GD442_21825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GD442_21830 ENOG4105DFF Rod shape-determining protein mreb GD442_21850 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GD442_21855 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GD442_21865 ENOG41068KH stage VI sporulation protein D GD442_21875 ENOG4105D52 delta-aminolevulinic acid dehydratase GD442_21900 ENOG4105K56 Transcriptional regulator GD442_21920 ENOG4108IUQ atp-dependent protease GD442_21945 ENOG4108QCI YvbH-like oligomerisation region GD442_21965 ENOG4105M59 Phosphodiesterase, mj0936 family GD442_21970 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GD442_21980 ENOG4108XJQ germination protein GD442_21990 ENOG4108PCX Major Facilitator GD442_22000 ENOG4105KBX Transcriptional regulator, TetR family GD442_22010 ENOG4105PFC Transcriptional regulator GD442_22085 ENOG4105PFC Transcriptional regulator GD442_22095 ENOG4105DZC cytosine deaminase GD442_22100 ENOG41067S9 phage shock protein C, PspC GD442_22105 ENOG4108JCI Transcriptional regulator GD442_22115 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GD442_22120 ENOG4108Z40 Transcriptional regulator GD442_22125 ENOG4105RHA ABC transporter, permease GD442_22130 ENOG4108IUX (ABC) transporter GD442_22135 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family GD442_22140 ENOG4105ER2 Ompa motb domain protein GD442_22145 ENOG4105E14 MotA TolQ exbB proton channel GD442_22150 ENOG4108VXD carboxy-peptidase GD442_22160 ENOG4105E33 succinate dehydrogenase GD442_22170 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GD442_22180 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GD442_22185 ENOG4105K63 Thioredoxin GD442_22190 ENOG4105C10 Electron transfer flavoprotein GD442_22195 ENOG4105BZJ Electron transfer flavoprotein GD442_22200 ENOG41060WC Enoyl-CoA hydratase GD442_22205 ENOG4107Z3H Transcriptional regulator, TetR family GD442_22210 ENOG4105CEY Amp-dependent synthetase and ligase GD442_22220 ENOG4105J76 Periplasmic binding protein GD442_22225 ENOG4105S6R Iron-hydroxamate transporter permease subunit GD442_22270 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_22280 ENOG4105DR4 Methyltransferase GD442_22290 ENOG4105KFN sortase, SrtB family GD442_22295 ENOG4105E0A ABC, transporter GD442_22310 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) GD442_22320 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) GD442_22330 ENOG4105FE9 pseudouridine synthase GD442_22340 ENOG4105DCG PHP domain protein GD442_22355 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GD442_22375 ENOG4105C5S asparaginyl-tRNA synthetase GD442_22380 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GD442_22390 ENOG4108RWN rrna methyltransferase GD442_22420 ENOG4105C0R drug resistance transporter emrb qaca subfamily GD442_22425 ENOG4105CW7 secretion protein, HlyD family GD442_22430 ENOG4108JGH Tetr family transcriptional regulator GD442_22435 ENOG4105CN9 Peptidase m42 family protein GD442_22455 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GD442_22460 ENOG4105C22 threonyL-tRNA synthetase GD442_22465 ENOG4108TDW sporulation protein YtxC GD442_22490 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GD442_22495 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GD442_22500 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GD442_22510 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GD442_22515 ENOG4105C2M dna polymerase I GD442_22520 ENOG4105BZU Histidine kinase GD442_22525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_22535 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_22540 ENOG4108HMX isocitrate dehydrogenase (NADP) GD442_22545 ENOG4105BZN citrate synthase GD442_22555 ENOG4108REF Sporulation integral membrane protein ytvi GD442_22560 ENOG4105FS0 cytoplasmic membrane protein GD442_22585 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GD442_22590 ENOG4105C6K Malic enzyme GD442_22595 ENOG4105C0B DNA polymerase III (alpha subunit) GD442_22600 ENOG4105VV2 GD442_22610 ENOG4105SFS phosphoesterase RecJ domain protein GD442_22630 ENOG4105E8R UPF0173 metal-dependent hydrolase GD442_22635 ENOG4105DC7 peptidase M24 GD442_22675 ENOG4105Z7P Acetyltransferase (GNAT) family GD442_22680 ENOG41082W1 Cupin 2, conserved barrel domain protein GD442_22700 ENOG4107YZX Universal stress protein GD442_22705 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GD442_22725 ENOG4105CH7 arginosuccinase GD442_22745 ENOG4108JYZ YitT family GD442_22765 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GD442_22775 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GD442_22780 ENOG4105KBJ sporulation protein ytfj GD442_22795 ENOG4105EFZ amidohydrolase GD442_22805 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GD442_22830 ENOG4106KR7 LysR family Transcriptional regulator GD442_22840 ENOG4105U5Y Transcriptional regulator GD442_22850 ENOG4105C28 cystathionine GD442_22870 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GD442_22875 ENOG4108UW5 maltose o-acetyltransferase GD442_22885 ENOG4105F1V Acetoin utilization protein GD442_22890 ENOG4105W87 Cbs domain GD442_22895 ENOG4105DGU Histone deacetylase GD442_22910 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GD442_22920 ENOG4107SNB ankyrin repeat protein YahD GD442_22925 ENOG4105EP9 oxidoreductase GD442_22955 ENOG4105ETE Transcriptional regulator (LacI family GD442_22960 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GD442_22980 ENOG4105C88 aminopeptidase GD442_23025 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GD442_23035 ENOG4108VDD TRNA binding domain protein GD442_23065 ENOG4105C8F Beta-lactamase domain protein GD442_23080 ENOG4108V15 phosphotransferase enzyme family GD442_23085 ENOG4108IUM Glycogen debranching enzyme GD442_23095 ENOG4107QSE Dipeptidase GD442_23100 ENOG4105YW5 deoR family transcriptional regulator GD442_23115 ENOG4105CBX hi0933 family GD442_23150 ENOG4108VJ1 Transcriptional regulator (CarD family GD442_23155 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GD442_23160 ENOG4105CSC Glucose uptake protein GD442_23175 ENOG4108ZAF Molybdopterin GD442_23180 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GD442_23185 ENOG4105CVM Molybdenum cofactor synthesis domain protein GD442_23195 ENOG4105D06 uba thif-type nad fad binding protein GD442_23200 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GD442_23220 ENOG41085GJ domain protein GD442_23230 ENOG4105DWV Homoserine O-trans-acetylase GD442_23240 ENOG4108B31 Spore germination protein GD442_23265 ENOG4105C8T Leucyl-tRNA synthetase GD442_23270 ENOG410605W Major Facilitator GD442_23275 ENOG4107S91 Sodium hydrogen exchanger GD442_23280 ENOG4105NCW Trka-c domain protein GD442_23295 ENOG4105C19 ABC transporter GD442_23315 ENOG4105N5T Radical SAM Protein GD442_23345 ENOG4105E8V Alpha Beta Hydrolase Fold protein GD442_23350 ENOG4108Z0R Transferase GD442_23355 ENOG4105YVM Phosphoesterase, PA-phosphatase related GD442_23360 ENOG4105BZF Glycosyl transferase (Group 1 GD442_23370 ENOG4105EPU Molybdenum cofactor synthesis domain protein GD442_23380 ENOG4108MK9 spermidine N(1)-acetyltransferase GD442_23430 ENOG4105BZU Histidine kinase GD442_23435 ENOG4105BZU Histidine kinase GD442_23450 ENOG4107S9D Alpha beta hydrolase GD442_23455 ENOG4107T7U Sulfatase GD442_23475 ENOG4105D2X ABC transporter substrate-binding protein GD442_23485 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GD442_23550 ENOG4108V2W Carbonate dehydratase GD442_23555 ENOG4105C4M (Ubiquinol oxidase) subunit I GD442_23560 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GD442_23595 ENOG41087YS Phage shock protein A GD442_23625 ENOG4105BZU Histidine kinase GD442_23630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_23655 ENOG4108UGV hypoxanthine phosphoribosyltransferase GD442_23660 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GD442_23685 ENOG4105C19 ABC transporter GD442_23700 ENOG4107ZTW SNARE associated Golgi GD442_23705 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GD442_23715 ENOG4105C19 ABC transporter GD442_23720 ENOG41086D8 Transcriptional regulator GD442_23735 ENOG41082BM Transcriptional regulator, arsr family GD442_23785 ENOG4105C6Z Gluconate GD442_23790 ENOG4105FDP GntR family transcriptional regulator GD442_23810 ENOG41069H0 dihydroorotase EC 3.5.2.3 GD442_23830 ENOG4105DTQ mandelate racemase muconate lactonizing GD442_23835 ENOG4105CEY Amp-dependent synthetase and ligase GD442_23840 ENOG4108IPT Naphthoate synthase GD442_23845 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GD442_23850 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GD442_23855 ENOG4105E4F Isochorismate synthase GD442_23860 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GD442_23870 ENOG4105VEQ Cold shock protein GD442_23900 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GD442_23905 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GD442_23915 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GD442_23920 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_24015 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GD442_24050 ENOG4105KT7 mgtC SapB transporter GD442_24055 ENOG4107PBV potassium channel GD442_24070 ENOG4105WG9 Conserved Protein GD442_24080 ENOG4105CHM Aminotransferase GD442_24085 ENOG4108ZB6 transcriptional regulator AsnC family GD442_24090 ENOG4105C5I Dehydrogenase GD442_24095 ENOG4108MUZ hydrolase GD442_24105 ENOG4105C87 Aminotransferase class I and II GD442_24115 ENOG4105Y38 Kinase-associated protein B GD442_24125 ENOG4107R3E Citrate transporter GD442_24140 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GD442_24145 ENOG4105KA0 thioesterase Superfamily protein GD442_24160 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GD442_24180 ENOG41069ER domain protein GD442_24195 ENOG4105CEP NADH dehydrogenase GD442_24225 ENOG4105EWC Purine nucleoside phosphorylase GD442_24245 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GD442_24270 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GD442_24275 ENOG4105C4B ABC transporter, permease GD442_24280 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GD442_24310 ENOG41083MR nifu domain-containing protein GD442_24325 ENOG4108W5N phosphatidylglycerophosphatase a GD442_24345 ENOG4105DAX Pfam:DUF2983 GD442_24355 ENOG4105DYS nad(p)h dehydrogenase (quinone) GD442_24360 ENOG4105D4U had-superfamily hydrolase, subfamily iia GD442_24375 ENOG4105CBT Fructose-1,6-bisphosphatase GD442_24390 ENOG4105MMD transcriptional regulator GD442_24395 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GD442_24400 ENOG4107TXC Transcriptional regulator GD442_24405 ENOG41090T1 Membrane GD442_24430 ENOG4105FAA peptidase M23 GD442_24435 ENOG4108YTE sporulation protein YunB GD442_24440 ENOG4105KZD Domain of unknown function (DUF1805) GD442_24445 ENOG4107R8B 5'-nucleotidase GD442_24450 ENOG4105DIW FeS assembly protein SUFB GD442_24455 ENOG4108UNV SUF system FeS assembly protein, NifU family GD442_24460 ENOG4105C9B Cysteine desulfurase GD442_24465 ENOG4105JRK feS assembly protein SufD GD442_24470 ENOG4105C3K feS assembly ATPase SufC GD442_24475 ENOG4105D01 (LipO)protein GD442_24480 ENOG4105D01 (LipO)protein GD442_24485 ENOG4108UMI ABC transporter, permease GD442_24515 ENOG41080E8 Transcriptional regulator, Spx MgsR family GD442_24535 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GD442_24560 ENOG4108W8B Beta-lactamase domain protein GD442_24565 ENOG4105C1G acyl-Coa dehydrogenase GD442_24570 ENOG4105CHU acetyl-coa acetyltransferase GD442_24585 ENOG4105DZ1 carboxypeptidase GD442_24605 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GD442_24610 ENOG4105D7V transposase GD442_24625 ENOG4108SUT Major Facilitator Superfamily GD442_24630 ENOG4107R7I amino acid GD442_24645 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GD442_24655 ENOG4107AYK membrAne GD442_24690 ENOG4107ZTW SNARE associated Golgi GD442_24700 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GD442_24705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_24710 ENOG4105BZU Histidine kinase GD442_24725 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GD442_24740 ENOG4105C8Q Methyl-accepting chemotaxis GD442_24745 ENOG4105VG1 fes assembly suf system protein GD442_24750 ENOG4105D4Y metalloprotease GD442_24770 ENOG4107T5V SNARE associated Golgi GD442_24775 ENOG4107S91 Sodium hydrogen exchanger GD442_24780 ENOG4105NCW Trka-c domain protein GD442_24790 ENOG4108RMU ferritin dps family protein GD442_24805 ENOG4108URH decarboxylase GD442_24815 ENOG41090A1 ferritin GD442_24825 ENOG4105D9N nucleoside GD442_24830 ENOG4105D9N nucleoside GD442_24845 ENOG4108RYK Nad-dependent epimerase dehydratase GD442_24860 ENOG4105CV8 reductase GD442_24865 ENOG4105F27 Major Facilitator GD442_24870 ENOG4105KVH Transcriptional regulator GD442_24885 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GD442_24890 ENOG4105D4A Cell wall formation (By similarity) GD442_24910 ENOG4105WMR Protein CrcB homolog GD442_24915 ENOG4105WMR Protein CrcB homolog GD442_24935 ENOG4105C5H ABC transporter GD442_24940 ENOG4108MK9 spermidine N(1)-acetyltransferase GD442_24945 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GD442_24980 ENOG4108IPW abc transporter atp-binding protein GD442_24985 ENOG4105CM4 permease protein GD442_25015 ENOG4105ST3 Transcriptional regulator GD442_25030 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GD442_25040 ENOG4105XZU Preprotein translocase, subunit SecG GD442_25045 ENOG41067MG lrgb family GD442_25065 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GD442_25095 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_25115 ENOG41090VF Stage v sporulation protein ac GD442_25120 ENOG4105CZ3 stage V sporulation protein ad GD442_25135 ENOG4108QY0 Membrane GD442_25140 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GD442_25145 ENOG4105KRI phosphocarrier protein (HPr GD442_25155 ENOG4105CHW UPF0052 protein GD442_25160 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GD442_25165 ENOG4108Z4K mutator MutT protein GD442_25175 ENOG4105C3M thioredoxin reductase GD442_25185 ENOG4108S4C acetyltransferase GD442_25195 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GD442_25205 ENOG41086DT Membrane protein of unknown function GD442_25210 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GD442_25215 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GD442_25230 ENOG4107TXC Transcriptional regulator GD442_25245 ENOG4105HMI Membrane GD442_25250 ENOG4105DUM transcriptional regulator, lysR family GD442_25260 ENOG4108WS4 fmn reductase GD442_25265 ENOG4105C5H ABC transporter GD442_25275 ENOG4105BZ1 (ABC) transporter GD442_25285 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GD442_25290 ENOG4107RSM transcriptional regulator GD442_25300 ENOG4105CN1 protease GD442_25305 ENOG4105CRP Part of the ABC transporter FtsEX involved in GD442_25310 ENOG4105CAK Cell division ATP-binding protein ftsE GD442_25335 ENOG4105MS2 ribosomal subunit Interface protein GD442_25340 ENOG4105VEQ Cold shock protein GD442_25345 ENOG41081UC Inherit from COG: Competence protein GD442_25355 ENOG4105K4H Nlp p60 protein GD442_25360 ENOG4105KVH Transcriptional regulator GD442_25370 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GD442_25375 ENOG4108KGH TRANSCRIPTIONal GD442_25380 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GD442_25385 ENOG4105C6Y Udp-glucose 6-dehydrogenase GD442_25390 ENOG4105ESV Glycosyl transferase, family 4 GD442_25400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GD442_25420 ENOG4105F8D glycoside hydrolase family 4 GD442_25425 ENOG4105VCP PTS System GD442_25430 ENOG4105CK1 PTS System GD442_25440 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GD442_25445 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GD442_25450 ENOG4105VCP PTS System GD442_25460 ENOG4105VZJ PTS System GD442_25480 ENOG4105ECB domain protein GD442_25485 ENOG4107RSM transcriptional regulator GD442_25515 ENOG4105DAA L-lactate GD442_25525 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) GD442_25535 ENOG4105E0M Sulfatase GD442_25560 ENOG4107R8N Glycosyl transferase, family 2 GD442_25565 ENOG4105C94 Transporter GD442_25570 ENOG41069ER domain protein GD442_25595 ENOG4105KBK Zinc finger, swim domain protein GD442_25600 ENOG4105C0D helicase GD442_25630 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GD442_25640 ENOG4107RBB ABC transporter, permease GD442_25645 ENOG4105C19 ABC transporter GD442_25655 ENOG4105CXY transporter GD442_25670 ENOG4105BZU Histidine kinase GD442_25675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_25680 ENOG4105CMR udp-glucose 4-epimerase GD442_25690 ENOG4108KGH TRANSCRIPTIONal GD442_25695 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GD442_25710 ENOG4108PTS heparinase ii GD442_25715 ENOG4105CJR Integral membrane protein (MviN GD442_25720 ENOG4107T8Q Glycosyl transferase (Group 1 GD442_25740 ENOG4105D3Q Sugar transferase GD442_25745 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GD442_25750 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GD442_25755 ENOG4107YJ4 chain length determinant protein GD442_25760 ENOG4105HTX biosynthesis protein GD442_25765 ENOG4107YJ4 chain length determinant protein GD442_25780 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GD442_25790 ENOG4105FRN stage II sporulation protein GD442_25805 ENOG4105DY9 regulatoR GD442_25825 ENOG4106778 Protein of unknown function (DUF1146) GD442_25830 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GD442_25835 ENOG4105C8S subunit m GD442_25840 ENOG4105D65 subunit l GD442_25865 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GD442_25870 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GD442_25880 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GD442_25885 ENOG4105BZU Histidine kinase GD442_25935 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GD442_25940 ENOG41062M3 atp synthase GD442_25960 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GD442_25965 ENOG4108UIC UPF0340 protein GD442_25970 ENOG4108YZG isomerase GD442_25985 ENOG4108VGI doxx family GD442_25990 ENOG4107XC4 flavin reductase domain protein, FMN-binding GD442_26005 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GD442_26015 ENOG4108ZXQ stage ii sporulation protein r GD442_26020 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GD442_26025 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GD442_26030 ENOG4107104 thymidine kinase GD442_26040 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GD442_26045 ENOG4105CBT Fructose-1,6-bisphosphatase GD442_26050 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GD442_26070 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GD442_26085 ENOG4105C1G acyl-Coa dehydrogenase GD442_26090 ENOG4105C1G acyl-Coa dehydrogenase GD442_26095 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GD442_26105 ENOG4105DF6 Fe-S oxidoreductase GD442_26120 ENOG4105BZU Histidine kinase GD442_26135 ENOG4105D4Y metalloprotease GD442_26145 ENOG4105BZU Histidine kinase GD442_26150 ENOG4105KCT ABC transporter GD442_26155 ENOG4108M15 ABC transporter GD442_26160 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GD442_26170 ENOG4105IIU Aminopeptidase GD442_26195 ENOG410684U Domain of unknown function (DUF1934) GD442_26215 ENOG4105CYW agmatinase GD442_26225 ENOG4105DXB Major Facilitator superfamily GD442_26230 ENOG4107SWG transcriptional regulator MERR family GD442_26235 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GD442_26240 ENOG4105BZ4 penicillin-binding protein GD442_26245 ENOG4108XFG YwhD family GD442_26250 ENOG4108Z4T Peptidase M50 GD442_26255 ENOG41069HH 4-oxalocrotonate tautomerase GD442_26260 ENOG4105DCI Phosphohydrolase GD442_26265 ENOG4108MES Periplasmic binding protein GD442_26270 ENOG4105E0A ABC, transporter GD442_26275 ENOG4105EHG Permease protein GD442_26280 ENOG4105DQ5 transport system permease protein GD442_26290 ENOG4108VCI transcription factor, rsfa family GD442_26295 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GD442_26300 ENOG4108IJ2 phosphate acetyltransferase GD442_26305 ENOG4107UEZ chlorite dismutase GD442_26315 ENOG4108VKI Cell wall hydrolase GD442_26335 ENOG4107SVH Potassium channel protein GD442_26345 ENOG410667J hydrolase GD442_26350 ENOG4105VCH membrane GD442_26360 ENOG4108TU7 Inherit from COG: (ABC) transporter GD442_26365 ENOG4105CJ1 ABC, transporter GD442_26370 ENOG41090WU lipolytic protein G-D-S-L family GD442_26385 ENOG4105D6E homoserine dehydrogenase GD442_26410 ENOG4108Y4K DNA-binding transcriptional activator GD442_26420 ENOG4105WH1 Two component transcriptional regulator luxr family GD442_26425 ENOG4105BZU Histidine kinase GD442_26430 ENOG4105DWF phosphomethylpyrimidine kinase GD442_26435 ENOG4105BZU Histidine kinase GD442_26440 ENOG4105VCD cytoplasmic protein GD442_26445 ENOG4105D22 carbon starvation protein GD442_26450 ENOG4105DY9 regulatoR GD442_26455 ENOG41079KZ Major Facilitator Superfamily GD442_26465 ENOG4105CG5 Glycosyl transferase (Group 1 GD442_26475 ENOG4105EN6 Membrane GD442_26480 ENOG4106YBV Methyl-accepting chemotaxis GD442_26490 ENOG4108S4H thioesterase Superfamily protein GD442_26495 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GD442_26510 ENOG4105K64 Glycosyl transferase, family 2 GD442_26520 ENOG4105EJV Membrane GD442_26525 ENOG4105CKK Glycosyl transferase, family 2 GD442_26530 ENOG4105C5H ABC transporter GD442_26535 ENOG41067SE Tetr family transcriptional regulator GD442_26545 ENOG4105E0X reductase GD442_26550 ENOG4106F5Q Membrane GD442_26565 ENOG4108NEV two component transcriptional regulator, LytTR family GD442_26570 ENOG4108HRK Histidine kinase GD442_26575 ENOG4107RGD Major Facilitator superfamily GD442_26590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GD442_26600 ENOG4105IW1 AmiS UreI transporter GD442_26605 ENOG4105CMR udp-glucose 4-epimerase GD442_26610 ENOG4108UT2 hemolysin iii GD442_26620 ENOG4105C1J atp-dependent rna helicase GD442_26625 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) GD442_26630 ENOG4105DPN Oligoendopeptidase f GD442_26640 ENOG4105BZU Histidine kinase GD442_26645 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GD442_26655 ENOG4105C0H protease GD442_26660 ENOG4105Q2H domain protein GD442_26675 ENOG4105BZU Histidine kinase GD442_26680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GD442_26705 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GD442_26710 ENOG4105CDU Replicative dna helicase GD442_26720 ENOG4105BZR domain protein GD442_26725 ENOG4108XMW Membrane GD442_26735 ENOG4108UUM single-stranded DNA-binding protein GD442_26745 ENOG4105C3G gtp-binding protein GD442_26750 ENOG4105VDK protein, conserved in bacteria GD442_26755 ENOG4105D8X mechanosensitive ion channel GD442_26760 ENOG4108ZDA Sporulation protein YyaC GD442_26765 ENOG4105FA0 parb-like partition protein GD442_26770 ENOG4107QJE Chromosome Partitioning Protein GD442_26785 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GD442_26790 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GD442_26800 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GD442_26905 ENOG4107JM4 Tetratricopeptide repeat GD442_26940 ENOG4107QJE Chromosome Partitioning Protein GD442_26960 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_26990 ENOG4105K4H Nlp p60 protein GD442_27110 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GD442_27295 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GD442_27310 ENOG4105K4H Nlp p60 protein GD442_27330 ENOG4108J59 Extracellular solute-binding protein, family 5 GD442_27355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GD442_27465 ENOG4105C9U ATP-dependent DNA helicase RecQ GD442_27525 ENOG4105K4H Nlp p60 protein