locus-tag	class	description
GNE05_00010	COG0592	DNA-directed DNA polymerase activity
GNE05_00015	COG2501	S4 domain
GNE05_00030	COG0187	DNA topoisomerase II activity
GNE05_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GNE05_00070	COG0516	GMP reductase activity
GNE05_00070	COG0517	IMP dehydrogenase activity
GNE05_00075	COG1686	Belongs to the peptidase S11 family
GNE05_00095	COG1929	Belongs to the glycerate kinase type-1 family
GNE05_00105	COG1428	Deoxynucleoside kinase
GNE05_00110	COG1428	Deoxynucleoside kinase
GNE05_00115	COG3858	chitin binding
GNE05_00115	COG1388	LysM domain
GNE05_00120	COG1335	isochorismatase
GNE05_00125	COG0590	tRNA wobble adenosine to inosine editing
GNE05_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GNE05_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GNE05_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GNE05_00195	COG3853	Toxic anion resistance protein (TelA)
GNE05_00200	COG1982	Orn Lys Arg decarboxylase major
GNE05_00210	COG3870	Protein conserved in bacteria
GNE05_00215	COG1728	Protein conserved in bacteria
GNE05_00220	COG0470	DNA polymerase III
GNE05_00225	COG1774	PSP1 C-terminal conserved region
GNE05_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GNE05_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GNE05_00250	COG2002	toxin-antitoxin pair type II binding
GNE05_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNE05_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNE05_00260	COG0084	hydrolase, TatD family'
GNE05_00265	COG3584	3D domain protein
GNE05_00265	COG3583	domain protein
GNE05_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GNE05_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GNE05_00285	COG4466	Protein conserved in bacteria
GNE05_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GNE05_00305	COG0251	oxidation-reduction process
GNE05_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GNE05_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GNE05_00345	COG2002	toxin-antitoxin pair type II binding
GNE05_00350	COG2244	polysaccharide biosynthetic process
GNE05_00355	COG3956	TIGRFAM MazG family protein
GNE05_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GNE05_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GNE05_00380	COG1098	S1 RNA binding domain
GNE05_00395	COG2208	phosphoserine phosphatase activity
GNE05_00400	COG2304	oxidoreductase activity
GNE05_00405	COG0515	serine threonine protein kinase
GNE05_00410	COG0037	tRNA processing
GNE05_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GNE05_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GNE05_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GNE05_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GNE05_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
GNE05_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GNE05_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GNE05_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GNE05_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GNE05_00475	COG1396	sequence-specific DNA binding
GNE05_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GNE05_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GNE05_00565	COG4463	regulation of RNA biosynthetic process
GNE05_00570	COG3880	PFAM UvrB UvrC protein
GNE05_00580	COG0542	response to heat
GNE05_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GNE05_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GNE05_00595	COG4956	integral membrane protein (PIN domain superfamily)
GNE05_00615	COG1045	serine acetyltransferase
GNE05_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GNE05_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GNE05_00635	COG3688	RNA-binding protein containing a PIN domain
GNE05_00640	COG1595	DNA-templated transcription, initiation
GNE05_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GNE05_00655	COG0250	Participates in transcription elongation, termination and antitermination
GNE05_00680	COG2813	Specifically methylates the guanine in position
GNE05_00695	COG1358	cellular component organization or biogenesis
GNE05_00720	COG0596	Alpha beta hydrolase
GNE05_00830	COG0201	protein transport
GNE05_00840	COG0024	Methionine aminopeptidase
GNE05_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GNE05_00880	COG1122	ATPase activity
GNE05_00885	COG1122	ATPase activity
GNE05_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GNE05_00910	COG2226	methyltransferase
GNE05_00915	COG2318	DinB family
GNE05_00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNE05_00930	COG0489	protein tyrosine kinase activity
GNE05_00940	COG2194	sulfuric ester hydrolase activity
GNE05_00945	COG0726	polysaccharide deacetylase
GNE05_00980	COG2856	Zn peptidase
GNE05_00990	COG1395	domain, Protein
GNE05_01055	COG0305	Participates in initiation and elongation during chromosome replication
GNE05_01065	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GNE05_01160	COG1783	phage Terminase large subunit
GNE05_01165	COG5518	Phage portal protein
GNE05_01170	COG2369	cell adhesion
GNE05_01180	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GNE05_01185	COG4653	Phage capsid family
GNE05_01240	COG5280	Phage tail tape measure protein TP901
GNE05_01240	COG3953	SLT domain
GNE05_01245	COG1652	LysM domain
GNE05_01250	COG4193	domain, Protein
GNE05_01260	COG3628	GPW Gp25 family protein
GNE05_01265	COG3299	homolog of phage Mu protein gp47
GNE05_01270	COG3778	Protein conserved in bacteria
GNE05_01320	COG0457	Tetratricopeptide repeat
GNE05_01325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GNE05_01360	COG0738	Major facilitator superfamily
GNE05_01365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GNE05_01380	COG0659	secondary active sulfate transmembrane transporter activity
GNE05_01385	COG0385	Bile acid
GNE05_01390	COG2819	hydrolase of the alpha beta superfamily
GNE05_01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_01400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_01405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNE05_01410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNE05_01410	COG2207	Transcriptional regulator
GNE05_01415	COG3876	Protein conserved in bacteria
GNE05_01420	COG1472	Belongs to the glycosyl hydrolase 3 family
GNE05_01425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GNE05_01430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNE05_01430	COG1263	PTS System
GNE05_01440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNE05_01445	COG1683	Conserved Protein
GNE05_01475	COG1595	DNA-templated transcription, initiation
GNE05_01480	COG5662	AntiSigma factor
GNE05_01485	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GNE05_01490	COG4856	YbbR-like protein
GNE05_01540	COG1346	cytolysis
GNE05_01545	COG1380	Effector of murein hydrolase LrgA
GNE05_01550	COG1846	Transcriptional regulator
GNE05_01555	COG1113	amino acid transport
GNE05_01560	COG1011	Hydrolase
GNE05_01565	COG4585	Histidine kinase
GNE05_01570	COG2197	response regulator
GNE05_01575	COG1131	(ABC) transporter
GNE05_01615	COG0531	amino acid
GNE05_01640	COG0584	glycerophosphoryl diester phosphodiesterase
GNE05_01645	COG2271	Major facilitator Superfamily
GNE05_01655	COG2368	4-hydroxyphenylacetate
GNE05_01665	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_01680	COG0371	Dehydrogenase
GNE05_01690	COG1183	phosphatidylcholine synthase activity
GNE05_01695	COG0586	Pfam SNARE associated Golgi protein
GNE05_01700	COG0688	phosphatidylethanolamine metabolic process
GNE05_01715	COG1301	dicarboxylic acid transport
GNE05_01720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GNE05_01725	COG0833	amino acid
GNE05_01730	COG2040	homocysteine
GNE05_01735	COG1115	amino acid carrier protein
GNE05_01740	COG2066	Belongs to the glutaminase family
GNE05_01745	COG4191	Histidine kinase
GNE05_01750	COG0784	Response regulator, receiver
GNE05_01755	COG3173	Aminoglycoside phosphotransferase
GNE05_01770	COG3773	Cell wall hydrolase
GNE05_01775	COG3540	Alkaline phosphatase
GNE05_01780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GNE05_01785	COG0805	protein transport
GNE05_01795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GNE05_01800	COG0477	Major facilitator Superfamily
GNE05_01805	COG1309	transcriptional regulator
GNE05_01810	COG0252	asparaginase activity
GNE05_01815	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GNE05_01820	COG3012	SEC-C Motif Domain Protein
GNE05_01820	COG1405	negative regulation of cell septum assembly
GNE05_01825	COG0667	Aldo Keto reductase
GNE05_01835	COG1595	DNA-templated transcription, initiation
GNE05_01840	COG1595	DNA-templated transcription, initiation
GNE05_01845	COG1876	peptidase activity
GNE05_01850	COG0457	Tetratricopeptide repeat
GNE05_01855	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_01860	COG0366	Alpha amylase catalytic
GNE05_01865	COG0803	Belongs to the bacterial solute-binding protein 9 family
GNE05_01870	COG1121	(ABC) transporter
GNE05_01875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GNE05_01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNE05_01885	COG2310	stress, protein
GNE05_01890	COG2310	stress, protein
GNE05_01895	COG2310	stress, protein
GNE05_01900	COG0861	Integral membrane protein TerC family
GNE05_01910	COG3853	Toxic anion resistance protein (TelA)
GNE05_01915	COG0477	Major facilitator Superfamily
GNE05_01920	COG4175	Glycine betaine
GNE05_01920	COG0517	IMP dehydrogenase activity
GNE05_01925	COG4176	ABC-type proline glycine betaine transport system permease component
GNE05_01930	COG2113	Glycine betaine
GNE05_01935	COG1473	amidohydrolase
GNE05_01940	COG1288	antiporter activity
GNE05_01950	COG0366	Alpha amylase catalytic
GNE05_01960	COG2814	Major facilitator Superfamily
GNE05_01965	COG1846	Transcriptional regulator
GNE05_01970	COG1280	lysine exporter protein (LysE YggA)
GNE05_01975	COG3403	YqcI/YcgG family
GNE05_01980	COG1113	amino acid transport
GNE05_01985	COG3665	Urea carboxylase-associated protein
GNE05_02000	COG1660	Displays ATPase and GTPase activities
GNE05_02005	COG1082	Xylose isomerase domain protein TIM barrel
GNE05_02010	COG2271	Major facilitator Superfamily
GNE05_02015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GNE05_02020	COG3458	cephalosporin-C deacetylase activity
GNE05_02025	COG3541	Predicted nucleotidyltransferase
GNE05_02030	COG0506	proline dehydrogenase activity
GNE05_02035	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_02040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNE05_02045	COG2508	Transcriptional regulator
GNE05_02055	COG1587	Uroporphyrinogen-III synthase
GNE05_02055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GNE05_02060	COG2146	nitrite reductase [NAD(P)H] activity
GNE05_02065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNE05_02070	COG0243	molybdopterin cofactor binding
GNE05_02075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GNE05_02080	COG2223	nitrite transmembrane transporter activity
GNE05_02085	COG0523	cobalamin synthesis protein
GNE05_02090	COG1063	alcohol dehydrogenase
GNE05_02095	COG1714	RDD family
GNE05_02105	COG2723	6-phospho-beta-galactosidase activity
GNE05_02115	COG3209	COG3209 Rhs family protein
GNE05_02120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GNE05_02125	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GNE05_02130	COG1733	regulation of RNA biosynthetic process
GNE05_02135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_02145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_02150	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GNE05_02165	COG2364	Membrane
GNE05_02170	COG1126	abc transporter atp-binding protein
GNE05_02175	COG0765	amino acid transport
GNE05_02180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNE05_02185	COG0583	DNA-binding transcription factor activity
GNE05_02190	COG0163	prenyltransferase activity
GNE05_02195	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GNE05_02210	COG3104	oligopeptide transport
GNE05_02215	COG5434	Belongs to the glycosyl hydrolase 28 family
GNE05_02225	COG0697	spore germination
GNE05_02235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GNE05_02240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNE05_02245	COG0456	acetyltransferase
GNE05_02250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNE05_02255	COG0765	amino acid transport
GNE05_02260	COG1126	abc transporter atp-binding protein
GNE05_02265	COG1473	amidohydrolase
GNE05_02270	COG2079	MmgE PrpD family protein
GNE05_02275	COG1136	(ABC) transporter
GNE05_02280	COG0577	efflux transmembrane transporter activity
GNE05_02285	COG0745	RESPONSE REGULATOR receiver
GNE05_02290	COG5002	protein histidine kinase activity
GNE05_02290	COG3850	Histidine kinase
GNE05_02295	COG0457	Tetratricopeptide repeat
GNE05_02310	COG0527	aspartate kinase activity
GNE05_02315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_02320	COG4605	iron ion homeostasis
GNE05_02325	COG4604	ABC transporter, ATP-binding protein
GNE05_02330	COG4607	ABC-type enterochelin transport system periplasmic component
GNE05_02335	COG2814	Major facilitator Superfamily
GNE05_02340	COG1309	transcriptional regulator
GNE05_02345	COG0778	Nitroreductase
GNE05_02350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GNE05_02355	COG0640	Transcriptional regulator
GNE05_02360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNE05_02365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GNE05_02370	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_02375	COG4975	Glucose uptake
GNE05_02380	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_02385	COG4549	nuclear export factor GLE1
GNE05_02390	COG1276	copper resistance
GNE05_02390	COG2372	response to copper ion
GNE05_02395	COG1349	DNA-binding transcription factor activity
GNE05_02405	COG2213	PTS system mannitol-specific
GNE05_02410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNE05_02420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GNE05_02430	COG0561	phosphatase activity
GNE05_02440	COG1914	H( )-stimulated, divalent metal cation uptake system
GNE05_02450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GNE05_02455	COG1984	allophanate hydrolase subunit 2
GNE05_02460	COG1414	Transcriptional regulator
GNE05_02465	COG2755	lipolytic protein G-D-S-L family
GNE05_02475	COG2329	Antibiotic biosynthesis monooxygenase
GNE05_02480	COG0768	penicillin binding
GNE05_02485	COG4989	oxidoreductase activity
GNE05_02490	COG3711	transcriptional antiterminator
GNE05_02495	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_02500	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_02505	COG1917	Cupin 2, conserved barrel domain protein
GNE05_02510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNE05_02515	COG3871	stress protein (general stress protein 26)
GNE05_02525	COG2814	Major facilitator Superfamily
GNE05_02530	COG1522	sequence-specific DNA binding
GNE05_02535	COG0551	DNA topoisomerase type I activity
GNE05_02535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GNE05_02540	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GNE05_02545	COG3706	GGDEF domain
GNE05_02550	COG5298	Protein conserved in bacteria
GNE05_02555	COG1215	transferase activity, transferring glycosyl groups
GNE05_02565	COG0531	amino acid
GNE05_02570	COG0494	nUDIX hydrolase
GNE05_02575	COG0028	Belongs to the TPP enzyme family
GNE05_02595	COG4282	regulation of fungal-type cell wall biogenesis
GNE05_02605	COG0457	Tetratricopeptide repeat
GNE05_02630	COG1914	H( )-stimulated, divalent metal cation uptake system
GNE05_02640	COG4876	unkown
GNE05_02650	COG2076	Multidrug Resistance protein
GNE05_02655	COG2217	Heavy metal translocating P-type atpase
GNE05_02665	COG0662	Cupin 2, conserved barrel domain protein
GNE05_02670	COG2329	Antibiotic biosynthesis monooxygenase
GNE05_02675	COG3546	catalase activity
GNE05_02680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GNE05_02685	COG3290	protein histidine kinase activity
GNE05_02690	COG4565	transcriptional regulatory protein
GNE05_02695	COG1301	dicarboxylic acid transport
GNE05_02700	COG0628	permease
GNE05_02705	COG1131	(ABC) transporter
GNE05_02710	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GNE05_02720	COG1960	acyl-CoA dehydrogenase activity
GNE05_02735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GNE05_02740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_02750	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GNE05_02755	COG0513	Belongs to the DEAD box helicase family
GNE05_02760	COG3402	PFAM membrane-flanked domain
GNE05_02765	COG3428	Bacterial PH domain
GNE05_02770	COG0705	Rhomboid family
GNE05_02780	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GNE05_02785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GNE05_02790	COG0864	Transcriptional regulator
GNE05_02795	COG2337	Toxic component of a toxin-antitoxin (TA) module
GNE05_02800	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_02805	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_02810	COG2172	sigma factor antagonist activity
GNE05_02815	COG2208	phosphoserine phosphatase activity
GNE05_02820	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_02830	COG1191	sigma factor activity
GNE05_02835	COG2208	phosphoserine phosphatase activity
GNE05_02840	COG2183	response to ionizing radiation
GNE05_02890	COG0457	Tetratricopeptide repeat
GNE05_02895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNE05_02900	COG0477	Major facilitator Superfamily
GNE05_02920	COG2030	dehydratase
GNE05_02935	COG1959	2 iron, 2 sulfur cluster binding
GNE05_02940	COG2910	NAD(P)H-binding
GNE05_02945	COG3239	Fatty acid desaturase
GNE05_02955	COG1278	Cold shock
GNE05_02960	COG1329	Transcriptional regulator
GNE05_02965	COG1937	Protein conserved in bacteria
GNE05_02970	COG2210	Belongs to the sulfur carrier protein TusA family
GNE05_02980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNE05_02980	COG0425	Belongs to the sulfur carrier protein TusA family
GNE05_02985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNE05_02985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNE05_02990	COG0425	Belongs to the sulfur carrier protein TusA family
GNE05_02995	COG0730	response to heat
GNE05_03000	COG1794	racemase activity, acting on amino acids and derivatives
GNE05_03015	COG3621	Patatin-like phospholipase
GNE05_03025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GNE05_03035	COG0251	oxidation-reduction process
GNE05_03040	COG0814	amino acid
GNE05_03045	COG1473	amidohydrolase
GNE05_03050	COG1917	Cupin 2, conserved barrel domain protein
GNE05_03050	COG2207	Transcriptional regulator
GNE05_03060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNE05_03065	COG0477	Major facilitator Superfamily
GNE05_03085	COG0277	FAD linked oxidase domain protein
GNE05_03135	COG0351	phosphomethylpyrimidine kinase
GNE05_03150	COG1064	alcohol dehydrogenase
GNE05_03155	COG0789	Transcriptional regulator
GNE05_03165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNE05_03180	COG2814	Major facilitator Superfamily
GNE05_03185	COG1309	transcriptional regulator
GNE05_03190	COG0697	spore germination
GNE05_03195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNE05_03200	COG5577	PFAM Coat F domain
GNE05_03210	COG1063	alcohol dehydrogenase
GNE05_03215	COG5577	PFAM Coat F domain
GNE05_03225	COG0738	Major facilitator superfamily
GNE05_03245	COG4585	Histidine kinase
GNE05_03250	COG2197	response regulator
GNE05_03255	COG2409	Drug exporters of the RND superfamily
GNE05_03260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GNE05_03270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNE05_03275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNE05_03285	COG2814	Major facilitator Superfamily
GNE05_03290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GNE05_03300	COG0730	response to heat
GNE05_03305	COG0456	acetyltransferase
GNE05_03310	COG0789	Transcriptional regulator
GNE05_03310	COG4978	Transcriptional regulator
GNE05_03315	COG0697	spore germination
GNE05_03320	COG1051	belongs to the nudix hydrolase family
GNE05_03325	COG2226	methyltransferase
GNE05_03330	COG0473	3-isopropylmalate dehydrogenase activity
GNE05_03335	COG1802	Transcriptional regulator
GNE05_03340	COG1819	glycosyl
GNE05_03355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GNE05_03360	COG1388	LysM domain
GNE05_03365	COG2814	Major facilitator Superfamily
GNE05_03370	COG2188	Transcriptional regulator
GNE05_03375	COG2186	Transcriptional regulator
GNE05_03380	COG2807	transmembrane transport
GNE05_03385	COG2076	Multidrug Resistance protein
GNE05_03390	COG2076	Multidrug Resistance protein
GNE05_03395	COG1309	transcriptional regulator
GNE05_03400	COG0531	amino acid
GNE05_03410	COG3832	glyoxalase III activity
GNE05_03415	COG0604	alcohol dehydrogenase
GNE05_03420	COG2814	Major facilitator Superfamily
GNE05_03460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GNE05_03465	COG0802	atpase or kinase
GNE05_03470	COG1214	PFAM Peptidase M22, glycoprotease
GNE05_03475	COG0456	acetyltransferase
GNE05_03480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GNE05_03485	COG0488	(ABC) transporter
GNE05_03500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GNE05_03505	COG0805	protein transport
GNE05_03515	COG1266	CAAX protease self-immunity
GNE05_03575	COG1131	(ABC) transporter
GNE05_03580	COG0842	Transport permease protein
GNE05_03585	COG0457	Tetratricopeptide repeat
GNE05_03590	COG1063	alcohol dehydrogenase
GNE05_03595	COG2211	Major facilitator Superfamily
GNE05_03600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GNE05_03610	COG1842	Phage shock protein A
GNE05_03615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GNE05_03620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GNE05_03625	COG4260	virion core protein, lumpy skin disease virus
GNE05_03630	COG2755	lipolytic protein G-D-S-L family
GNE05_03630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GNE05_03640	COG1595	DNA-templated transcription, initiation
GNE05_03645	COG1063	alcohol dehydrogenase
GNE05_03650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GNE05_03655	COG0823	Involved in the tonB-independent uptake of proteins
GNE05_03670	COG2132	Multicopper oxidase
GNE05_03675	COG1113	amino acid transport
GNE05_03680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GNE05_03685	COG0714	Associated with various cellular activities
GNE05_03690	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GNE05_03695	COG1305	Transglutaminase-like
GNE05_03705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GNE05_03725	COG2211	Major facilitator Superfamily
GNE05_03740	COG2252	PERMEase
GNE05_03745	COG3064	Membrane
GNE05_03765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GNE05_03770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GNE05_03775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GNE05_03780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GNE05_03785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GNE05_03800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GNE05_03810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GNE05_03815	COG0138	bifunctional purine biosynthesis protein purh
GNE05_03820	COG0151	Belongs to the GarS family
GNE05_03830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GNE05_03835	COG1470	cell adhesion involved in biofilm formation
GNE05_03840	COG4496	protein, YerC YecD
GNE05_03845	COG0069	glutamate synthase activity
GNE05_03855	COG0210	DNA helicase
GNE05_03865	COG4851	CamS sex pheromone cAM373 precursor
GNE05_03870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GNE05_03875	COG1285	pathogenesis
GNE05_03880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNE05_03900	COG1309	transcriptional regulator
GNE05_03905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GNE05_03910	COG1597	lipid kinase activity
GNE05_03915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GNE05_03955	COG5444	nuclease activity
GNE05_03965	COG5444	nuclease activity
GNE05_03990	COG3546	catalase activity
GNE05_03995	COG0454	-acetyltransferase
GNE05_04005	COG2323	membrane
GNE05_04010	COG2329	Antibiotic biosynthesis monooxygenase
GNE05_04015	COG0346	lactoylglutathione lyase activity
GNE05_04020	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_04025	COG5583	Uncharacterized small protein (DUF2292)
GNE05_04030	COG0196	riboflavin kinase activity
GNE05_04035	COG0670	Belongs to the BI1 family
GNE05_04040	COG1846	Transcriptional regulator
GNE05_04045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GNE05_04055	COG2124	cytochrome p450
GNE05_04055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GNE05_04060	COG1368	sulfuric ester hydrolase activity
GNE05_04065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GNE05_04070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNE05_04075	COG1442	glycosyl transferase family 8
GNE05_04080	COG1216	Glycosyl transferase, family 2
GNE05_04085	COG1442	glycosyl transferase family 8
GNE05_04090	COG2223	nitrite transmembrane transporter activity
GNE05_04095	COG0531	amino acid
GNE05_04100	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_04105	COG0840	transmembrane signaling receptor activity
GNE05_04110	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_04115	COG0463	Glycosyl transferase, family 2
GNE05_04115	COG0457	Tetratricopeptide repeat
GNE05_04120	COG0488	(ABC) transporter
GNE05_04125	COG0789	Transcriptional regulator
GNE05_04130	COG2814	Major facilitator Superfamily
GNE05_04135	COG0488	(ABC) transporter
GNE05_04140	COG0513	Belongs to the DEAD box helicase family
GNE05_04150	COG2130	NADP-dependent
GNE05_04165	COG3866	Pectate lyase
GNE05_04170	COG0471	metal ion transport
GNE05_04190	COG3290	protein histidine kinase activity
GNE05_04195	COG4565	transcriptional regulatory protein
GNE05_04200	COG3181	Tripartite tricarboxylate transporter family receptor
GNE05_04205	COG2851	Citrate transporter
GNE05_04210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNE05_04215	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GNE05_04225	COG2258	MOSC domain
GNE05_04245	COG0024	Methionine aminopeptidase
GNE05_04250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNE05_04250	COG1263	PTS System
GNE05_04260	COG1368	sulfuric ester hydrolase activity
GNE05_04270	COG0071	Belongs to the small heat shock protein (HSP20) family
GNE05_04285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNE05_04285	COG1263	PTS System
GNE05_04290	COG0366	Alpha amylase catalytic
GNE05_04295	COG2188	Transcriptional regulator
GNE05_04300	COG0778	Nitroreductase
GNE05_04315	COG0737	Belongs to the 5'-nucleotidase family
GNE05_04320	COG0693	protein deglycase activity
GNE05_04325	COG1609	Transcriptional regulator
GNE05_04340	COG2814	Major facilitator Superfamily
GNE05_04350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GNE05_04355	COG4980	gas vesicle protein
GNE05_04360	COG1295	ribonuclease BN
GNE05_04365	COG0477	Major facilitator Superfamily
GNE05_04370	COG0387	Pfam Sodium calcium exchanger
GNE05_04380	COG0668	transmembrane transport
GNE05_04385	COG0535	radical SAM domain protein
GNE05_04395	COG0726	polysaccharide deacetylase
GNE05_04400	COG2084	Dehydrogenase
GNE05_04410	COG0598	Magnesium transport protein CorA
GNE05_04415	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GNE05_04420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GNE05_04430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GNE05_04435	COG4637	Psort location Cytoplasmic, score
GNE05_04440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GNE05_04445	COG0022	dehydrogenase e1 component
GNE05_04450	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNE05_04455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GNE05_04460	COG3284	Transcriptional regulator
GNE05_04470	COG1486	melibiose metabolic process
GNE05_04475	COG1737	Transcriptional regulator
GNE05_04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNE05_04480	COG1263	PTS System
GNE05_04485	COG1132	(ABC) transporter
GNE05_04490	COG1132	(ABC) transporter
GNE05_04495	COG2259	Doxx family
GNE05_04500	COG2514	catechol 2,3-dioxygenase activity
GNE05_04505	COG1917	Cupin 2, conserved barrel domain protein
GNE05_04505	COG4977	sequence-specific DNA binding
GNE05_04510	COG2814	Major facilitator Superfamily
GNE05_04515	COG1082	Xylose isomerase domain protein TIM barrel
GNE05_04520	COG0673	inositol 2-dehydrogenase activity
GNE05_04530	COG1695	Transcriptional regulator
GNE05_04535	COG2249	NAD(P)H dehydrogenase (quinone) activity
GNE05_04540	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GNE05_04545	COG3848	Pyruvate phosphate dikinase
GNE05_04545	COG0574	Belongs to the PEP-utilizing enzyme family
GNE05_04550	COG2732	(Barnase) inhibitor
GNE05_04555	COG2318	DinB family
GNE05_04560	COG2814	Major facilitator Superfamily
GNE05_04565	COG1846	Transcriptional regulator
GNE05_04570	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GNE05_04570	COG0392	lysyltransferase activity
GNE05_04575	COG0384	phenazine biosynthesis protein PhzF
GNE05_04580	COG0778	Nitroreductase
GNE05_04595	COG1090	epimerase
GNE05_04610	COG2814	Major facilitator Superfamily
GNE05_04620	COG3591	Belongs to the peptidase S1B family
GNE05_04635	COG3103	Sh3 type 3 domain protein
GNE05_04640	COG5658	integral membrane protein
GNE05_04645	COG0596	Alpha beta hydrolase
GNE05_04650	COG0463	Glycosyl transferase, family 2
GNE05_04655	COG4485	Bacterial membrane protein, YfhO
GNE05_04660	COG1988	membrane-bound metal-dependent
GNE05_04665	COG1194	a g-specific adenine glycosylase
GNE05_04675	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_04695	COG1132	(ABC) transporter
GNE05_04700	COG4129	membrane
GNE05_04710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GNE05_04715	COG0735	belongs to the Fur family
GNE05_04825	COG1757	Na H antiporter
GNE05_04830	COG3340	Belongs to the peptidase S51 family
GNE05_04840	COG0277	FAD linked oxidase domain protein
GNE05_04850	COG0747	negative chemotaxis
GNE05_04855	COG0601	transmembrane transport
GNE05_04860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GNE05_04865	COG0444	Belongs to the ABC transporter superfamily
GNE05_04870	COG4608	Belongs to the ABC transporter superfamily
GNE05_04875	COG0753	catalase activity
GNE05_04885	COG1116	anion transmembrane transporter activity
GNE05_04890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GNE05_04895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GNE05_04915	COG1476	TRANSCRIPTIONal
GNE05_04925	COG3382	B3 4 domain protein
GNE05_04930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GNE05_04940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GNE05_04945	COG0789	Transcriptional regulator
GNE05_04950	COG1664	Polymer-forming cytoskeletal
GNE05_04955	COG1664	Polymer-forming cytoskeletal
GNE05_04960	COG2766	serine protein kinase
GNE05_04970	COG1846	Transcriptional regulator
GNE05_04975	COG1566	PFAM secretion protein HlyD family protein
GNE05_04980	COG2814	Major facilitator Superfamily
GNE05_04985	COG0655	NAD(P)H dehydrogenase (quinone) activity
GNE05_05000	COG1725	Transcriptional regulator
GNE05_05005	COG1131	(ABC) transporter
GNE05_05010	COG1131	(ABC) transporter
GNE05_05015	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GNE05_05020	COG1278	Cold shock
GNE05_05025	COG1464	Belongs to the NlpA lipoprotein family
GNE05_05030	COG3706	GGDEF domain
GNE05_05035	COG1823	symporter activity
GNE05_05055	COG5577	PFAM Coat F domain
GNE05_05060	COG4085	toxin activity
GNE05_05060	COG1525	nuclease
GNE05_05060	COG0737	Belongs to the 5'-nucleotidase family
GNE05_05065	COG3764	Sortase (surface protein transpeptidase)
GNE05_05070	COG0564	pseudouridine synthase activity
GNE05_05080	COG0517	IMP dehydrogenase activity
GNE05_05085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GNE05_05090	COG3153	acetyltransferase
GNE05_05090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GNE05_05095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GNE05_05100	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GNE05_05105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GNE05_05115	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GNE05_05120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GNE05_05125	COG4585	Histidine kinase
GNE05_05125	COG2203	Gaf domain
GNE05_05130	COG2197	response regulator
GNE05_05135	COG0431	NADPH-dependent FMN reductase
GNE05_05150	COG1388	LysM domain
GNE05_05150	COG0791	NLP P60 protein
GNE05_05155	COG1959	2 iron, 2 sulfur cluster binding
GNE05_05160	COG0668	transmembrane transport
GNE05_05165	COG2719	SpoVR family
GNE05_05170	COG1785	Belongs to the alkaline phosphatase family
GNE05_05175	COG0791	NLP P60 protein
GNE05_05175	COG1388	LysM domain
GNE05_05180	COG0583	DNA-binding transcription factor activity
GNE05_05185	COG0372	Belongs to the citrate synthase family
GNE05_05190	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_05195	COG0531	amino acid
GNE05_05200	COG0733	neurotransmitter:sodium symporter activity
GNE05_05215	COG1595	DNA-templated transcription, initiation
GNE05_05220	COG0204	Acyl-transferase
GNE05_05225	COG1253	flavin adenine dinucleotide binding
GNE05_05230	COG0789	Transcriptional regulator
GNE05_05235	COG0436	Aminotransferase
GNE05_05240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GNE05_05245	COG1253	flavin adenine dinucleotide binding
GNE05_05250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GNE05_05255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GNE05_05260	COG0584	glycerophosphoryl diester phosphodiesterase
GNE05_05270	COG0668	transmembrane transport
GNE05_05275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GNE05_05280	COG0726	polysaccharide deacetylase
GNE05_05285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GNE05_05290	COG3226	Transcriptional regulator
GNE05_05300	COG0589	response to stress
GNE05_05305	COG1132	(ABC) transporter
GNE05_05310	COG1132	(ABC) transporter
GNE05_05315	COG0702	epimerase
GNE05_05330	COG0189	ligase activity
GNE05_05335	COG0189	ligase activity
GNE05_05355	COG0561	phosphatase activity
GNE05_05360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GNE05_05370	COG0475	glutathione-regulated potassium exporter activity
GNE05_05375	COG0490	domain, Protein
GNE05_05385	COG1024	Enoyl-CoA hydratase
GNE05_05395	COG4152	abc transporter atp-binding protein
GNE05_05400	COG1668	transmembrane transport
GNE05_05405	COG0420	3'-5' exonuclease activity
GNE05_05410	COG4717	serine-type aminopeptidase activity
GNE05_05425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GNE05_05460	COG4980	gas vesicle protein
GNE05_05475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GNE05_05480	COG0537	adenosine 5'-monophosphoramidase activity
GNE05_05485	COG1131	(ABC) transporter
GNE05_05490	COG4473	ABC transporter
GNE05_05500	COG1473	amidohydrolase
GNE05_05505	COG3069	C4-dicarboxylate transmembrane transporter activity
GNE05_05510	COG2329	Antibiotic biosynthesis monooxygenase
GNE05_05515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNE05_05535	COG1309	transcriptional regulator
GNE05_05540	COG1511	domain protein
GNE05_05545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GNE05_05555	COG1363	Peptidase, m42
GNE05_05560	COG1301	dicarboxylic acid transport
GNE05_05570	COG1234	tRNA 3'-trailer cleavage
GNE05_05575	COG0095	Lipoate-protein ligase
GNE05_05580	COG0702	epimerase
GNE05_05585	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_05595	COG0501	Belongs to the peptidase M48B family
GNE05_05600	COG1404	Belongs to the peptidase S8 family
GNE05_05610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GNE05_05615	COG0406	alpha-ribazole phosphatase activity
GNE05_05620	COG0183	Belongs to the thiolase family
GNE05_05625	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_05630	COG1268	BioY protein
GNE05_05635	COG0840	transmembrane signaling receptor activity
GNE05_05640	COG0723	plastoquinol--plastocyanin reductase activity
GNE05_05640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNE05_05645	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_05655	COG4903	ComK protein
GNE05_05665	COG5646	InterPro IPR014922
GNE05_05690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNE05_05705	COG0398	Pfam SNARE associated Golgi protein
GNE05_05710	COG0681	Belongs to the peptidase S26 family
GNE05_05715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GNE05_05720	COG1846	Transcriptional regulator
GNE05_05725	COG3180	Ammonia monooxygenase
GNE05_05730	COG2814	Major facilitator Superfamily
GNE05_05740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GNE05_05745	COG2323	membrane
GNE05_05760	COG0420	3'-5' exonuclease activity
GNE05_05765	COG0419	ATPase involved in DNA repair
GNE05_05770	COG1403	HNH endonuclease
GNE05_05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
GNE05_05825	COG0367	asparagine synthase
GNE05_05830	COG1562	ergosterol biosynthetic process
GNE05_05835	COG0534	Mate efflux family protein
GNE05_05840	COG1917	Cupin 2, conserved barrel domain protein
GNE05_05840	COG2207	Transcriptional regulator
GNE05_05845	COG2318	DinB family
GNE05_05850	COG1279	arginine transmembrane transporter activity
GNE05_05855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNE05_05860	COG1357	PFAM Pentapeptide repeats (8 copies)
GNE05_05865	COG2153	protein acetylation
GNE05_05870	COG0646	methionine synthase
GNE05_05870	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GNE05_05880	COG2996	Protein conserved in bacteria
GNE05_05890	COG0840	transmembrane signaling receptor activity
GNE05_05895	COG2124	cytochrome p450
GNE05_05905	COG1307	EDD domain protein, DegV family
GNE05_05910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNE05_05925	COG0561	phosphatase activity
GNE05_05930	COG1073	alpha beta
GNE05_05935	COG2151	metal-sulfur cluster biosynthetic enzyme
GNE05_05945	COG0277	FAD linked oxidase domain protein
GNE05_05950	COG2271	Major facilitator Superfamily
GNE05_05960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GNE05_05970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GNE05_05975	COG0505	Belongs to the CarA family
GNE05_05980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GNE05_05985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GNE05_06000	COG2267	carboxylic ester hydrolase activity
GNE05_06010	COG1744	ABC transporter substrate-binding protein PnrA-like
GNE05_06025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GNE05_06030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GNE05_06035	COG5504	Zn-dependent protease
GNE05_06040	COG0444	Belongs to the ABC transporter superfamily
GNE05_06045	COG4608	Belongs to the ABC transporter superfamily
GNE05_06055	COG0601	transmembrane transport
GNE05_06060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GNE05_06070	COG2814	Major facilitator Superfamily
GNE05_06080	COG0180	Tryptophanyl-tRNA synthetase
GNE05_06085	COG4166	transmembrane transport
GNE05_06090	COG0601	transmembrane transport
GNE05_06095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GNE05_06100	COG0444	Belongs to the ABC transporter superfamily
GNE05_06105	COG4608	Belongs to the ABC transporter superfamily
GNE05_06115	COG0456	acetyltransferase
GNE05_06120	COG1393	Belongs to the ArsC family
GNE05_06125	COG0861	Integral membrane protein TerC family
GNE05_06130	COG4862	establishment of competence for transformation
GNE05_06135	COG4469	Competence protein
GNE05_06140	COG1164	Oligoendopeptidase f
GNE05_06150	COG2346	COG2346, Truncated hemoglobins
GNE05_06155	COG0741	lytic transglycosylase activity
GNE05_06160	COG4116	CYTH
GNE05_06170	COG2357	RelA SpoT domain protein
GNE05_06175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GNE05_06180	COG0564	pseudouridine synthase activity
GNE05_06190	COG0569	domain protein
GNE05_06190	COG0475	glutathione-regulated potassium exporter activity
GNE05_06195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GNE05_06200	COG0352	thiamine-phosphate diphosphorylase activity
GNE05_06205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNE05_06210	COG2104	thiamine diphosphate biosynthetic process
GNE05_06220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GNE05_06225	COG0351	phosphomethylpyrimidine kinase
GNE05_06230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GNE05_06285	COG0210	DNA helicase
GNE05_06305	COG1131	(ABC) transporter
GNE05_06315	COG2153	protein acetylation
GNE05_06325	COG2382	esterase
GNE05_06330	COG0626	cystathionine gamma-synthase activity
GNE05_06335	COG0626	cystathionine gamma-synthase activity
GNE05_06400	COG3655	Transcriptional regulator
GNE05_06460	COG2367	Beta-lactamase
GNE05_06465	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GNE05_06470	COG0477	Major facilitator Superfamily
GNE05_06475	COG1846	Transcriptional regulator
GNE05_06485	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GNE05_06490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GNE05_06495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GNE05_06500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GNE05_06500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GNE05_06505	COG1447	Phosphotransferase system cellobiose-specific component IIA
GNE05_06530	COG1285	pathogenesis
GNE05_06545	COG2205	protein histidine kinase activity
GNE05_06555	COG3383	formate dehydrogenase (NAD+) activity
GNE05_06560	COG2427	Protein of unknown function (DUF1641)
GNE05_06565	COG2124	cytochrome p450
GNE05_06570	COG1819	glycosyl
GNE05_06580	COG1587	Uroporphyrinogen-III synthase
GNE05_06585	COG0390	transport system, permease component
GNE05_06590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GNE05_06595	COG0697	spore germination
GNE05_06600	COG4297	protein containing double-stranded beta helix domain
GNE05_06610	COG1252	NADH dehydrogenase
GNE05_06620	COG2211	Major facilitator Superfamily
GNE05_06625	COG1609	Transcriptional regulator
GNE05_06630	COG0246	Mannitol dehydrogenase
GNE05_06635	COG2721	sulfolactate sulfo-lyase activity
GNE05_06640	COG0730	response to heat
GNE05_06645	COG2318	DinB family
GNE05_06650	COG0457	Tetratricopeptide repeat
GNE05_06660	COG1388	LysM domain
GNE05_06660	COG5632	N-Acetylmuramoyl-L-alanine amidase
GNE05_06660	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_06670	COG4195	phage-related replication protein
GNE05_06675	COG3546	catalase activity
GNE05_06680	COG2856	Zn peptidase
GNE05_06685	COG1396	sequence-specific DNA binding
GNE05_06695	COG1522	sequence-specific DNA binding
GNE05_06700	COG1484	DNA-dependent DNA replication
GNE05_06715	COG1595	DNA-templated transcription, initiation
GNE05_06720	COG3728	DNA packaging
GNE05_06720	COG5484	DNA packaging
GNE05_06725	COG1783	phage Terminase large subunit
GNE05_06730	COG5518	Phage portal protein
GNE05_06735	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GNE05_06740	COG4653	Phage capsid family
GNE05_06790	COG5412	phage tail tape measure protein
GNE05_06790	COG3953	SLT domain
GNE05_06790	COG5412	phage tail tape measure protein
GNE05_06790	COG3953	SLT domain
GNE05_06790	COG3953	SLT domain
GNE05_06790	COG5412	phage tail tape measure protein
GNE05_06795	COG1652	LysM domain
GNE05_06800	COG4193	domain, Protein
GNE05_06810	COG3628	GPW Gp25 family protein
GNE05_06815	COG3299	homolog of phage Mu protein gp47
GNE05_06820	COG3778	Protein conserved in bacteria
GNE05_06860	COG5632	N-Acetylmuramoyl-L-alanine amidase
GNE05_06860	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_06875	COG0306	phosphate transporter
GNE05_06880	COG1392	Phosphate transport regulator
GNE05_06885	COG0531	amino acid
GNE05_06890	COG0346	lactoylglutathione lyase activity
GNE05_06895	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GNE05_06900	COG0463	Glycosyl transferase, family 2
GNE05_06905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNE05_06910	COG0477	Major facilitator Superfamily
GNE05_06915	COG2362	D-Aminopeptidase
GNE05_06920	COG0601	transmembrane transport
GNE05_06925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GNE05_06930	COG0444	Belongs to the ABC transporter superfamily
GNE05_06935	COG4166	transmembrane transport
GNE05_06940	COG1619	proteins homologs of microcin C7 resistance protein MccF
GNE05_06945	COG4948	Mandelate Racemase Muconate Lactonizing
GNE05_06950	COG0791	NLP P60 protein
GNE05_06955	COG4608	Belongs to the ABC transporter superfamily
GNE05_06960	COG2706	6-phosphogluconolactonase activity
GNE05_06965	COG1834	amidinotransferase
GNE05_06970	COG1607	acyl-coa hydrolase
GNE05_06975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNE05_06980	COG2076	Multidrug Resistance protein
GNE05_06985	COG2076	Multidrug Resistance protein
GNE05_06990	COG0788	formyltetrahydrofolate deformylase activity
GNE05_06995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GNE05_07005	COG1764	response to oxidative stress
GNE05_07010	COG1846	Transcriptional regulator
GNE05_07015	COG1764	response to oxidative stress
GNE05_07030	COG0463	Glycosyl transferase, family 2
GNE05_07030	COG0457	Tetratricopeptide repeat
GNE05_07040	COG2814	Major facilitator Superfamily
GNE05_07045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNE05_07055	COG1404	Belongs to the peptidase S8 family
GNE05_07060	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_07065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GNE05_07070	COG1122	ATPase activity
GNE05_07075	COG4721	ABC-type cobalt transport system, permease component
GNE05_07080	COG1388	LysM domain
GNE05_07080	COG3858	chitin binding
GNE05_07095	COG2239	Acts as a magnesium transporter
GNE05_07100	COG0789	Transcriptional regulator
GNE05_07115	COG1846	Transcriptional regulator
GNE05_07120	COG0726	polysaccharide deacetylase
GNE05_07125	COG3285	dna ligase
GNE05_07125	COG1793	dna ligase
GNE05_07130	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GNE05_07135	COG0586	Pfam SNARE associated Golgi protein
GNE05_07140	COG0861	Integral membrane protein TerC family
GNE05_07145	COG1191	sigma factor activity
GNE05_07170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GNE05_07175	COG2323	membrane
GNE05_07185	COG3594	Acyltransferase
GNE05_07190	COG5002	protein histidine kinase activity
GNE05_07195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GNE05_07210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GNE05_07215	COG0436	Aminotransferase
GNE05_07245	COG3852	Histidine kinase
GNE05_07250	COG1846	Transcriptional regulator
GNE05_07255	COG1360	Flagellar Motor Protein
GNE05_07260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GNE05_07265	COG0542	response to heat
GNE05_07270	COG3949	Membrane
GNE05_07285	COG0720	synthase
GNE05_07290	COG0602	queuosine metabolic process
GNE05_07305	COG1733	regulation of RNA biosynthetic process
GNE05_07310	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_07320	COG1388	LysM domain
GNE05_07320	COG4641	Protein conserved in bacteria
GNE05_07325	COG1388	LysM domain
GNE05_07330	COG3858	chitin binding
GNE05_07340	COG4873	Protein conserved in bacteria
GNE05_07350	COG3773	Cell wall hydrolase
GNE05_07355	COG2244	polysaccharide biosynthetic process
GNE05_07360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_07365	COG2217	Heavy metal translocating P-type atpase
GNE05_07370	COG0006	proline dipeptidase activity
GNE05_07375	COG1609	Transcriptional regulator
GNE05_07380	COG3711	transcriptional antiterminator
GNE05_07385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNE05_07385	COG2190	(PTS) system
GNE05_07385	COG1263	PTS System
GNE05_07390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNE05_07395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GNE05_07405	COG1533	DNA photolyase activity
GNE05_07410	COG0840	transmembrane signaling receptor activity
GNE05_07415	COG2084	Dehydrogenase
GNE05_07420	COG2340	Cysteine-rich secretory protein family
GNE05_07425	COG0768	penicillin binding
GNE05_07430	COG4191	Histidine kinase
GNE05_07435	COG0436	Aminotransferase
GNE05_07440	COG0784	Response regulator, receiver
GNE05_07440	COG0835	chemotaxis
GNE05_07450	COG2814	Major facilitator Superfamily
GNE05_07455	COG1376	ErfK ybiS ycfS ynhG family protein
GNE05_07460	COG1408	metallophosphoesterase
GNE05_07465	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_07475	COG2200	EAL domain
GNE05_07480	COG4703	Protein of unknown function (DUF1797)
GNE05_07485	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GNE05_07495	COG0517	IMP dehydrogenase activity
GNE05_07500	COG0583	DNA-binding transcription factor activity
GNE05_07505	COG0716	FMN binding
GNE05_07515	COG0716	FMN binding
GNE05_07535	COG0668	transmembrane transport
GNE05_07540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_07560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GNE05_07565	COG0303	'Molybdopterin
GNE05_07570	COG1763	Mo-molybdopterin cofactor biosynthetic process
GNE05_07575	COG0314	molybdopterin synthase activity
GNE05_07580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GNE05_07590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GNE05_07595	COG1136	(ABC) transporter
GNE05_07600	COG0577	efflux transmembrane transporter activity
GNE05_07605	COG1349	DNA-binding transcription factor activity
GNE05_07610	COG1105	Belongs to the carbohydrate kinase PfkB family
GNE05_07615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNE05_07615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNE05_07615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNE05_07620	COG0681	Belongs to the peptidase S26 family
GNE05_07630	COG0488	(ABC) transporter
GNE05_07635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GNE05_07640	COG2309	aminopeptidase activity
GNE05_07650	COG1077	Cell shape determining protein MreB Mrl
GNE05_07655	COG2002	toxin-antitoxin pair type II binding
GNE05_07660	COG3852	Histidine kinase
GNE05_07665	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GNE05_07665	COG2105	PFAM AIG2 family protein
GNE05_07670	COG0569	domain protein
GNE05_07680	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GNE05_07690	COG0561	phosphatase activity
GNE05_07695	COG0242	peptide deformylase activity
GNE05_07705	COG0497	DNA recombination
GNE05_07715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_07715	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_07715	COG3321	synthase
GNE05_07715	COG4221	oxidoreductase activity
GNE05_07720	COG3321	synthase
GNE05_07720	COG4221	oxidoreductase activity
GNE05_07720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_07720	COG0300	oxidoreductase activity
GNE05_07725	COG3321	synthase
GNE05_07725	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_07725	COG4221	oxidoreductase activity
GNE05_07725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_07730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_07730	COG4221	oxidoreductase activity
GNE05_07730	COG3321	synthase
GNE05_07730	COG0300	oxidoreductase activity
GNE05_07735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_07735	COG0300	oxidoreductase activity
GNE05_07735	COG3321	synthase
GNE05_07735	COG4221	oxidoreductase activity
GNE05_07740	COG0300	oxidoreductase activity
GNE05_07740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_07740	COG3321	synthase
GNE05_07740	COG4221	oxidoreductase activity
GNE05_07745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_07745	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_07745	COG3321	synthase
GNE05_07745	COG4221	oxidoreductase activity
GNE05_07750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GNE05_07755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GNE05_07760	COG0022	dehydrogenase e1 component
GNE05_07765	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNE05_07770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GNE05_07775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_07790	COG1982	Orn Lys Arg decarboxylase major
GNE05_07810	COG0483	inositol monophosphate 1-phosphatase activity
GNE05_07820	COG3227	Zinc metalloprotease (Elastase)
GNE05_07855	COG4896	Protein conserved in bacteria
GNE05_07865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GNE05_07870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GNE05_07875	COG2066	Belongs to the glutaminase family
GNE05_07885	COG0772	Belongs to the SEDS family
GNE05_07890	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GNE05_07905	COG2010	Cytochrome c
GNE05_07905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GNE05_07910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GNE05_07915	COG1845	cytochrome c oxidase, subunit III
GNE05_07920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GNE05_07925	COG3336	cytochrome c oxidase
GNE05_07940	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GNE05_07945	COG2340	Cysteine-rich secretory protein family
GNE05_07960	COG3679	Belongs to the UPF0342 family
GNE05_07970	COG0742	ribosomal rna small subunit methyltransferase
GNE05_07980	COG3314	Sporulation integral membrane protein YlbJ
GNE05_07985	COG1752	Esterase of the alpha-beta hydrolase superfamily
GNE05_07990	COG3480	Lon protease (S16) C-terminal proteolytic domain
GNE05_08005	COG1399	metal-binding, possibly nucleic acid-binding protein
GNE05_08025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GNE05_08045	COG4839	cell division protein FtsL
GNE05_08055	COG0768	penicillin binding
GNE05_08075	COG0772	Belongs to the SEDS family
GNE05_08090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GNE05_08095	COG0849	cell division
GNE05_08100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GNE05_08105	COG1404	Belongs to the peptidase S8 family
GNE05_08105	COG4412	M6 family metalloprotease domain protein
GNE05_08115	COG1191	sigma factor activity
GNE05_08120	COG1191	sigma factor activity
GNE05_08125	COG1119	ATPase activity
GNE05_08130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNE05_08135	COG1873	PFAM PRC-barrel domain
GNE05_08145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GNE05_08155	COG0762	integral membrane protein
GNE05_08160	COG2302	S4 RNA-binding domain
GNE05_08165	COG3599	regulation of cell shape
GNE05_08170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GNE05_08175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GNE05_08185	COG0564	pseudouridine synthase activity
GNE05_08195	COG2233	PERMEase
GNE05_08205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GNE05_08210	COG0505	Belongs to the CarA family
GNE05_08215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GNE05_08230	COG0284	orotidine-5'-phosphate decarboxylase activity
GNE05_08235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GNE05_08245	COG0306	phosphate transporter
GNE05_08260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GNE05_08265	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GNE05_08270	COG1648	precorrin-2 dehydrogenase activity
GNE05_08280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GNE05_08285	COG1561	YicC-like family, N-terminal region
GNE05_08295	COG0194	GDP metabolic process
GNE05_08305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GNE05_08310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GNE05_08315	COG0242	peptide deformylase activity
GNE05_08325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GNE05_08325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GNE05_08335	COG0631	protein serine/threonine phosphatase activity
GNE05_08340	COG2815	serine threonine protein kinase
GNE05_08340	COG0515	serine threonine protein kinase
GNE05_08350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GNE05_08355	COG1564	THIamine pyrophosphokinase
GNE05_08370	COG1302	Protein conserved in bacteria
GNE05_08375	COG1461	Dihydroxyacetone kinase
GNE05_08380	COG1760	l-serine dehydratase
GNE05_08385	COG1760	l-serine dehydratase
GNE05_08390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GNE05_08405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GNE05_08410	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_08425	COG1196	nuclear chromosome segregation
GNE05_08430	COG0552	protein localization to endoplasmic reticulum
GNE05_08445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GNE05_08455	COG1837	Belongs to the UPF0109 family
GNE05_08480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GNE05_08495	COG2257	FlhB HrpN YscU SpaS Family
GNE05_08505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GNE05_08510	COG0758	DNA mediated transformation
GNE05_08515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GNE05_08525	COG4974	Belongs to the 'phage' integrase family
GNE05_08545	COG1815	bacterial-type flagellum-dependent cell motility
GNE05_08550	COG1558	bacterial-type flagellum-dependent cell motility
GNE05_08555	COG1677	Flagellar hook-basal body complex protein FliE
GNE05_08560	COG1766	The M ring may be actively involved in energy transduction
GNE05_08565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GNE05_08570	COG1317	bacterial-type flagellum organization
GNE05_08575	COG1157	protein secretion by the type III secretion system
GNE05_08580	COG2882	bacterial-type flagellum organization
GNE05_08585	COG3334	PFAM MgtE intracellular
GNE05_08590	COG3144	bacterial-type flagellum assembly
GNE05_08595	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GNE05_08600	COG4786	Flagellar basal body rod
GNE05_08605	COG1582	Flagellar protein (FlbD)
GNE05_08610	COG1580	Controls the rotational direction of flagella during chemotaxis
GNE05_08615	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GNE05_08620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GNE05_08620	COG1776	CheC inhibitor of MCP methylation
GNE05_08625	COG2201	protein-glutamate methylesterase activity
GNE05_08630	COG3190	flagellar
GNE05_08635	COG1338	Plays a role in the flagellum-specific transport system
GNE05_08640	COG1987	bacterial-type flagellum assembly
GNE05_08645	COG1684	flagellar biosynthetic protein fliR
GNE05_08650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GNE05_08655	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GNE05_08660	COG1419	protein localization to endoplasmic reticulum
GNE05_08665	COG0455	bacterial-type flagellum organization
GNE05_08670	COG2201	protein-glutamate methylesterase activity
GNE05_08675	COG2198	Histidine kinase
GNE05_08675	COG0643	Histidine kinase
GNE05_08680	COG0835	chemotaxis
GNE05_08685	COG1776	CheC inhibitor of MCP methylation
GNE05_08695	COG1191	sigma factor activity
GNE05_08725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GNE05_08730	COG4589	Belongs to the CDS family
GNE05_08740	COG0750	zinc metalloprotease
GNE05_08750	COG2176	DNA-directed DNA polymerase activity
GNE05_08760	COG0195	Participates in both transcription termination and antitermination
GNE05_08765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GNE05_08770	COG1358	cellular component organization or biogenesis
GNE05_08780	COG1550	Protein conserved in bacteria
GNE05_08795	COG0196	riboflavin kinase activity
GNE05_08810	COG0726	polysaccharide deacetylase
GNE05_08815	COG0612	Peptidase, M16
GNE05_08820	COG1873	PFAM PRC-barrel domain
GNE05_08825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GNE05_08830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GNE05_08835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GNE05_08840	COG0527	aspartate kinase activity
GNE05_08850	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GNE05_08855	COG0740	serine-type endopeptidase activity
GNE05_08865	COG4980	gas vesicle protein
GNE05_08865	COG1674	ftsk spoiiie
GNE05_08870	COG2188	Transcriptional regulator
GNE05_08875	COG2814	Major facilitator Superfamily
GNE05_08880	COG1846	Transcriptional regulator
GNE05_08885	COG1033	growth of symbiont in host cell
GNE05_08885	COG2409	Drug exporters of the RND superfamily
GNE05_08890	COG0612	Peptidase, M16
GNE05_08895	COG0612	Peptidase, M16
GNE05_08900	COG0300	oxidoreductase activity
GNE05_08915	COG1426	Protein conserved in bacteria
GNE05_08920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GNE05_08935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GNE05_08945	COG1692	metallophosphoesterase
GNE05_08950	COG2359	stage V sporulation protein S
GNE05_08970	COG4550	Control of competence regulator ComK, YlbF/YmcA
GNE05_09055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_09060	COG3425	synthase
GNE05_09065	COG1024	Enoyl-CoA hydratase
GNE05_09070	COG1024	Enoyl-CoA hydratase
GNE05_09075	COG0300	oxidoreductase activity
GNE05_09075	COG3321	synthase
GNE05_09075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09075	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_09075	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_09080	COG0300	oxidoreductase activity
GNE05_09080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_09080	COG4221	oxidoreductase activity
GNE05_09080	COG3321	synthase
GNE05_09085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNE05_09085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09085	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_09085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNE05_09085	COG3321	synthase
GNE05_09085	COG3321	synthase
GNE05_09085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_09085	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_09085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_09090	COG4221	oxidoreductase activity
GNE05_09090	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_09090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09090	COG3321	synthase
GNE05_09095	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GNE05_09095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GNE05_09095	COG3321	synthase
GNE05_09095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_09100	COG2124	cytochrome p450
GNE05_09105	COG3209	COG3209 Rhs family protein
GNE05_09110	COG3619	membrane
GNE05_09120	COG1404	Belongs to the peptidase S8 family
GNE05_09130	COG4195	phage-related replication protein
GNE05_09135	COG1764	response to oxidative stress
GNE05_09145	COG2076	Multidrug Resistance protein
GNE05_09185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNE05_09190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNE05_09195	COG4112	unkown
GNE05_09200	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNE05_09210	COG0464	growth
GNE05_09215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GNE05_09220	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GNE05_09225	COG0789	Transcriptional regulator
GNE05_09230	COG0174	glutamine synthetase
GNE05_09240	COG2211	Major facilitator Superfamily
GNE05_09245	COG3507	Belongs to the glycosyl hydrolase 43 family
GNE05_09260	COG1070	Carbohydrate kinase
GNE05_09265	COG3848	Pyruvate phosphate dikinase
GNE05_09265	COG0574	Belongs to the PEP-utilizing enzyme family
GNE05_09285	COG2378	regulation of single-species biofilm formation
GNE05_09290	COG2318	DinB family
GNE05_09295	COG1064	alcohol dehydrogenase
GNE05_09310	COG0456	acetyltransferase
GNE05_09315	COG5444	nuclease activity
GNE05_09360	COG3397	chitin binding
GNE05_09370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNE05_09380	COG5434	Belongs to the glycosyl hydrolase 28 family
GNE05_09385	COG0756	dUTP diphosphatase activity
GNE05_09390	COG4195	phage-related replication protein
GNE05_09420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GNE05_09430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GNE05_09450	COG0785	Cytochrome C biogenesis protein
GNE05_09455	COG2201	protein-glutamate methylesterase activity
GNE05_09460	COG4846	Membrane protein involved in cytochrome C biogenesis
GNE05_09470	COG0071	Belongs to the small heat shock protein (HSP20) family
GNE05_09485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GNE05_09490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_09510	COG0824	Thioesterase
GNE05_09520	COG4841	protein insertion into membrane
GNE05_09530	COG1832	CoA-binding protein
GNE05_09535	COG0187	DNA topoisomerase II activity
GNE05_09540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GNE05_09550	COG1115	amino acid carrier protein
GNE05_09560	COG1063	alcohol dehydrogenase
GNE05_09565	COG0800	Aldolase
GNE05_09570	COG1312	Catalyzes the dehydration of D-mannonate
GNE05_09575	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_09580	COG1609	Transcriptional regulator
GNE05_09585	COG2271	Major facilitator Superfamily
GNE05_09625	COG2205	protein histidine kinase activity
GNE05_09630	COG0745	RESPONSE REGULATOR receiver
GNE05_09640	COG3507	Belongs to the glycosyl hydrolase 43 family
GNE05_09665	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_09670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GNE05_09675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GNE05_09680	COG2610	gluconate transmembrane transporter activity
GNE05_09685	COG2124	cytochrome p450
GNE05_09705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GNE05_09715	COG2246	polysaccharide biosynthetic process
GNE05_09720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GNE05_09725	COG0586	Pfam SNARE associated Golgi protein
GNE05_09730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GNE05_09735	COG1024	Enoyl-CoA hydratase
GNE05_09740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GNE05_09745	COG0511	ligase activity, forming carbon-carbon bonds
GNE05_09750	COG0439	Biotin carboxylase
GNE05_09755	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_09760	COG1960	acyl-CoA dehydrogenase activity
GNE05_09765	COG1649	PFAM Uncharacterised BCR, COG1649
GNE05_09775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09775	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GNE05_09780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_09800	COG2027	D-alanyl-D-alanine carboxypeptidase
GNE05_09805	COG2017	converts alpha-aldose to the beta-anomer
GNE05_09825	COG0582	viral genome integration into host DNA
GNE05_09830	COG0166	Belongs to the GPI family
GNE05_09835	COG0405	Gamma-glutamyltransferase
GNE05_09840	COG2814	Major facilitator Superfamily
GNE05_09845	COG0640	Transcriptional regulator
GNE05_09850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GNE05_09860	COG0604	alcohol dehydrogenase
GNE05_09865	COG0493	'glutamate synthase
GNE05_09870	COG0067	glutamate synthase
GNE05_09870	COG0070	glutamate synthase
GNE05_09870	COG0069	glutamate synthase activity
GNE05_09875	COG0583	DNA-binding transcription factor activity
GNE05_09880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GNE05_09895	COG0300	oxidoreductase activity
GNE05_09900	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GNE05_09910	COG2814	Major facilitator Superfamily
GNE05_09915	COG1070	Carbohydrate kinase
GNE05_09920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GNE05_09925	COG0243	molybdopterin cofactor binding
GNE05_09955	COG5444	nuclease activity
GNE05_09960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNE05_09965	COG0662	Cupin 2, conserved barrel domain protein
GNE05_09965	COG2207	Transcriptional regulator
GNE05_09970	COG1309	transcriptional regulator
GNE05_09975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNE05_09985	COG0640	Transcriptional regulator
GNE05_09990	COG0741	lytic transglycosylase activity
GNE05_09995	COG2322	membrane
GNE05_10010	COG1619	proteins homologs of microcin C7 resistance protein MccF
GNE05_10020	COG1388	LysM domain
GNE05_10020	COG3584	3D domain protein
GNE05_10025	COG0514	ATP-dependent DNA helicase (RecQ)
GNE05_10035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GNE05_10040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GNE05_10055	COG0071	Belongs to the small heat shock protein (HSP20) family
GNE05_10085	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_10090	COG1657	PFAM Prenyltransferase squalene oxidase
GNE05_10095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GNE05_10100	COG0733	neurotransmitter:sodium symporter activity
GNE05_10105	COG0385	Bile acid
GNE05_10110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNE05_10115	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNE05_10125	COG4548	von Willebrand factor, type A
GNE05_10130	COG0714	Associated with various cellular activities
GNE05_10135	COG2032	superoxide dismutase activity
GNE05_10140	COG0791	NLP P60 protein
GNE05_10140	COG1388	LysM domain
GNE05_10145	COG1819	glycosyl
GNE05_10150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GNE05_10155	COG0534	Mate efflux family protein
GNE05_10160	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_10165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GNE05_10170	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GNE05_10180	COG2962	Rard protein
GNE05_10195	COG1942	4-Oxalocrotonate Tautomerase
GNE05_10205	COG1733	regulation of RNA biosynthetic process
GNE05_10210	COG0778	Nitroreductase
GNE05_10215	COG0400	carboxylic ester hydrolase activity
GNE05_10220	COG0346	lactoylglutathione lyase activity
GNE05_10230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GNE05_10240	COG2723	6-phospho-beta-galactosidase activity
GNE05_10245	COG2188	Transcriptional regulator
GNE05_10250	COG0793	Belongs to the peptidase S41A family
GNE05_10250	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_10255	COG2226	methyltransferase
GNE05_10265	COG1876	peptidase activity
GNE05_10285	COG0671	phosphoesterase, PA-phosphatase related
GNE05_10310	COG1509	lysine 2,3-aminomutase activity
GNE05_10315	COG0456	acetyltransferase
GNE05_10320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNE05_10325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GNE05_10330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GNE05_10335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GNE05_10340	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GNE05_10350	COG0456	acetyltransferase
GNE05_10355	COG0463	Glycosyl transferase, family 2
GNE05_10370	COG4641	Protein conserved in bacteria
GNE05_10380	COG1086	Polysaccharide biosynthesis protein
GNE05_10405	COG1388	LysM domain
GNE05_10410	COG0457	Tetratricopeptide repeat
GNE05_10420	COG3391	amine dehydrogenase activity
GNE05_10455	COG5444	nuclease activity
GNE05_10460	COG4282	regulation of fungal-type cell wall biogenesis
GNE05_10465	COG1525	nuclease
GNE05_10480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GNE05_10500	COG1846	Transcriptional regulator
GNE05_10505	COG4698	Protein conserved in bacteria
GNE05_10510	COG2755	lipolytic protein G-D-S-L family
GNE05_10515	COG1999	signal sequence binding
GNE05_10525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GNE05_10530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GNE05_10535	COG1272	protein, Hemolysin III
GNE05_10545	COG0204	Acyl-transferase
GNE05_10550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GNE05_10565	COG2136	Putative SAM-dependent methyltransferase
GNE05_10565	COG2521	methyltransferase
GNE05_10580	COG1413	lyase activity
GNE05_10585	COG1418	mRNA catabolic process
GNE05_10590	COG0386	Belongs to the glutathione peroxidase family
GNE05_10600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GNE05_10610	COG1278	Cold shock
GNE05_10630	COG0328	RNA-DNA hybrid ribonuclease activity
GNE05_10635	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GNE05_10640	COG0328	RNA-DNA hybrid ribonuclease activity
GNE05_10650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNE05_10665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GNE05_10675	COG1755	Isoprenylcysteine carboxyl methyltransferase
GNE05_10680	COG3424	synthase
GNE05_10700	COG1335	isochorismatase
GNE05_10715	COG3331	DNA recombination
GNE05_10760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GNE05_10795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GNE05_10820	COG0756	dUTP diphosphatase activity
GNE05_10830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_10865	COG1372	Participates in initiation and elongation during chromosome replication
GNE05_10865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GNE05_10870	COG1780	Probably involved in ribonucleotide reductase function
GNE05_10970	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
GNE05_10975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GNE05_10985	COG3584	3D domain protein
GNE05_10990	COG0587	DNA-directed DNA polymerase activity
GNE05_10995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GNE05_11000	COG0358	DNA primase activity
GNE05_11005	COG0305	Participates in initiation and elongation during chromosome replication
GNE05_11015	COG2887	Belongs to the helicase family. UvrD subfamily
GNE05_11035	COG3420	alginic acid biosynthetic process
GNE05_11035	COG5434	Belongs to the glycosyl hydrolase 28 family
GNE05_11040	COG4195	phage-related replication protein
GNE05_11055	COG2135	peptidase activity
GNE05_11060	COG1793	dna ligase
GNE05_11135	COG3655	Transcriptional regulator
GNE05_11220	COG3655	Transcriptional regulator
GNE05_11295	COG0776	regulation of translation
GNE05_11435	COG0582	viral genome integration into host DNA
GNE05_11455	COG0739	heme binding
GNE05_11455	COG0741	lytic transglycosylase activity
GNE05_11455	COG1196	nuclear chromosome segregation
GNE05_11475	COG5434	Belongs to the glycosyl hydrolase 28 family
GNE05_11480	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_11480	COG5632	N-Acetylmuramoyl-L-alanine amidase
GNE05_11500	COG0457	Tetratricopeptide repeat
GNE05_11505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GNE05_11540	COG5444	nuclease activity
GNE05_11545	COG1525	nuclease
GNE05_11565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GNE05_11570	COG1199	ATP-dependent helicase activity
GNE05_11585	COG0116	Belongs to the methyltransferase superfamily
GNE05_11615	COG3359	exonuclease
GNE05_11620	COG1205	dead DEAH box helicase
GNE05_11620	COG1111	helicase
GNE05_11625	COG2190	(PTS) system
GNE05_11630	COG0071	Belongs to the small heat shock protein (HSP20) family
GNE05_11670	COG4499	WXG100 protein secretion system (Wss), protein YukC
GNE05_11670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNE05_11680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GNE05_11685	COG3935	DnaD domain protein
GNE05_11695	COG0436	Aminotransferase
GNE05_11700	COG5353	protein conserved in bacteria
GNE05_11710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GNE05_11710	COG1199	ATP-dependent helicase activity
GNE05_11740	COG0438	transferase activity, transferring glycosyl groups
GNE05_11745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GNE05_11760	COG1694	Mazg nucleotide pyrophosphohydrolase
GNE05_11765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNE05_11770	COG2140	Oxalate decarboxylase
GNE05_11780	COG4347	Protein of unknown function (DUF1405)
GNE05_11785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GNE05_11785	COG2010	Cytochrome c
GNE05_11790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GNE05_11795	COG0723	plastoquinol--plastocyanin reductase activity
GNE05_11810	COG0457	Tetratricopeptide repeat
GNE05_11820	COG0287	Prephenate dehydrogenase
GNE05_11855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GNE05_11860	COG4401	Chorismate mutase type I
GNE05_11875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GNE05_11880	COG0105	UTP biosynthetic process
GNE05_11885	COG0142	geranyltranstransferase activity
GNE05_11895	COG0142	geranyltranstransferase activity
GNE05_11910	COG0776	regulation of translation
GNE05_11915	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GNE05_11955	COG0539	negative regulation of cytoplasmic translation
GNE05_11970	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GNE05_11975	COG2959	enzyme of heme biosynthesis
GNE05_11980	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_11980	COG3773	Cell wall hydrolase
GNE05_11985	COG2339	peptidase activity
GNE05_11990	COG0492	ferredoxin-NADP+ reductase activity
GNE05_11995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GNE05_12000	COG4862	establishment of competence for transformation
GNE05_12005	COG1408	metallophosphoesterase
GNE05_12015	COG1388	LysM domain
GNE05_12020	COG1266	CAAX protease self-immunity
GNE05_12025	COG0514	ATP-dependent DNA helicase (RecQ)
GNE05_12030	COG4955	Helix-turn-helix domain
GNE05_12035	COG1141	Ferredoxin
GNE05_12040	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GNE05_12045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GNE05_12055	COG1595	DNA-templated transcription, initiation
GNE05_12060	COG5002	protein histidine kinase activity
GNE05_12065	COG0745	RESPONSE REGULATOR receiver
GNE05_12070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GNE05_12075	COG1333	cytochrome c biogenesis protein
GNE05_12080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_12085	COG1187	pseudouridine synthase activity
GNE05_12090	COG0700	Nucleoside recognition
GNE05_12095	COG2715	membrane protein required for spore maturation
GNE05_12100	COG1686	Belongs to the peptidase S11 family
GNE05_12125	COG1547	Domain of unknown function (DUF309)
GNE05_12130	COG0456	acetyltransferase
GNE05_12145	COG0307	riboflavin synthase, alpha
GNE05_12150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GNE05_12150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GNE05_12160	COG0681	Belongs to the peptidase S26 family
GNE05_12170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GNE05_12175	COG4086	secreted protein
GNE05_12180	COG0019	diaminopimelate decarboxylase activity
GNE05_12185	COG0697	spore germination
GNE05_12200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GNE05_12220	COG1191	sigma factor activity
GNE05_12230	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_12235	COG1686	Belongs to the peptidase S11 family
GNE05_12240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GNE05_12245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GNE05_12250	COG4974	Belongs to the 'phage' integrase family
GNE05_12260	COG0735	belongs to the Fur family
GNE05_12265	COG1300	Membrane
GNE05_12280	COG0281	malic enzyme
GNE05_12285	COG1757	Na H antiporter
GNE05_12290	COG1027	Aspartate ammonia-lyase
GNE05_12295	COG0252	asparaginase activity
GNE05_12300	COG1396	sequence-specific DNA binding
GNE05_12305	COG1379	DNA repair
GNE05_12310	COG0494	nUDIX hydrolase
GNE05_12320	COG0667	Aldo Keto reductase
GNE05_12330	COG1073	alpha beta
GNE05_12340	COG4918	Iron-sulphur cluster biosynthesis
GNE05_12345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GNE05_12345	COG0456	acetyltransferase
GNE05_12350	COG2329	Antibiotic biosynthesis monooxygenase
GNE05_12355	COG0456	acetyltransferase
GNE05_12360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GNE05_12375	COG0628	permease
GNE05_12385	COG0346	lactoylglutathione lyase activity
GNE05_12395	COG3048	D-serine ammonia-lyase activity
GNE05_12400	COG0300	oxidoreductase activity
GNE05_12405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNE05_12410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GNE05_12415	COG1024	Enoyl-CoA hydratase
GNE05_12420	COG3425	synthase
GNE05_12425	COG2124	cytochrome p450
GNE05_12430	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12430	COG3321	synthase
GNE05_12430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_12430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_12430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNE05_12435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNE05_12435	COG3321	synthase
GNE05_12435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_12435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_12435	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12440	COG3321	synthase
GNE05_12440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_12440	COG0300	oxidoreductase activity
GNE05_12440	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_12440	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12445	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_12445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_12445	COG0300	oxidoreductase activity
GNE05_12445	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12445	COG3321	synthase
GNE05_12450	COG3321	synthase
GNE05_12450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_12450	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNE05_12450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_12455	COG3321	synthase
GNE05_12455	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_12455	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_12455	COG0300	oxidoreductase activity
GNE05_12460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GNE05_12460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_12460	COG3321	synthase
GNE05_12460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GNE05_12460	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12465	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_12470	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_12485	COG2070	2-Nitropropane dioxygenase
GNE05_12485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GNE05_12490	COG0250	Participates in transcription elongation, termination and antitermination
GNE05_12515	COG0596	Alpha beta hydrolase
GNE05_12530	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GNE05_12535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GNE05_12550	COG0706	membrane insertase activity
GNE05_12555	COG2195	Cleaves the N-terminal amino acid of tripeptides
GNE05_12560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GNE05_12565	COG0346	lactoylglutathione lyase activity
GNE05_12575	COG1376	ErfK ybiS ycfS ynhG family protein
GNE05_12580	COG4129	membrane
GNE05_12585	COG1126	abc transporter atp-binding protein
GNE05_12590	COG0765	amino acid transport
GNE05_12595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNE05_12605	COG1597	lipid kinase activity
GNE05_12610	COG0508	dehydrogenase complex catalyzes the overall conversion of
GNE05_12615	COG0022	dehydrogenase e1 component
GNE05_12620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GNE05_12625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GNE05_12630	COG3426	butyrate kinase activity
GNE05_12635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GNE05_12640	COG0280	phosphate acetyltransferase
GNE05_12645	COG3829	transcription factor binding
GNE05_12645	COG3290	protein histidine kinase activity
GNE05_12655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GNE05_12660	COG2079	MmgE PrpD family protein
GNE05_12665	COG0372	Belongs to the citrate synthase family
GNE05_12670	COG1960	acyl-CoA dehydrogenase activity
GNE05_12675	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNE05_12680	COG0183	Belongs to the thiolase family
GNE05_12685	COG0584	glycerophosphoryl diester phosphodiesterase
GNE05_12690	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNE05_12710	COG1902	pentaerythritol trinitrate reductase activity
GNE05_12725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GNE05_12730	COG0745	RESPONSE REGULATOR receiver
GNE05_12735	COG0750	zinc metalloprotease
GNE05_12740	COG0497	DNA recombination
GNE05_12750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GNE05_12760	COG0142	geranyltranstransferase activity
GNE05_12770	COG1570	exodeoxyribonuclease VII activity
GNE05_12785	COG1302	Protein conserved in bacteria
GNE05_12790	COG0439	Biotin carboxylase
GNE05_12795	COG0511	ligase activity, forming carbon-carbon bonds
GNE05_12835	COG3854	ATPases associated with a variety of cellular activities
GNE05_12850	COG0006	proline dipeptidase activity
GNE05_12860	COG3872	metal-dependent enzyme
GNE05_12870	COG1752	Esterase of the alpha-beta hydrolase superfamily
GNE05_12885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNE05_12905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GNE05_12920	COG1396	sequence-specific DNA binding
GNE05_12930	COG0681	Belongs to the peptidase S26 family
GNE05_12955	COG4940	Competence protein ComGF
GNE05_12965	COG4970	Tfp pilus assembly protein FimT
GNE05_12970	COG4537	Required for transformation and DNA binding
GNE05_12975	COG1459	type II secretion system
GNE05_12980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GNE05_12985	COG0598	Magnesium transport protein CorA
GNE05_12990	COG1253	flavin adenine dinucleotide binding
GNE05_12995	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_13005	COG1393	Belongs to the ArsC family
GNE05_13015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNE05_13025	COG0011	TIGRFAM Protein of
GNE05_13035	COG2866	Carboxypeptidase
GNE05_13040	COG1940	carbohydrate kinase activity
GNE05_13045	COG4483	Protein conserved in bacteria
GNE05_13050	COG1757	Na H antiporter
GNE05_13060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GNE05_13075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GNE05_13080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GNE05_13085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GNE05_13090	COG0581	inorganic phosphate transmembrane transporter activity
GNE05_13095	COG0573	inorganic phosphate transmembrane transporter activity
GNE05_13100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GNE05_13110	COG0477	Major facilitator Superfamily
GNE05_13115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GNE05_13120	COG2839	Protein conserved in bacteria
GNE05_13125	COG5521	maltodextrose utilization protein MalA
GNE05_13130	COG1388	LysM domain
GNE05_13140	COG4709	membrane
GNE05_13145	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GNE05_13150	COG0735	belongs to the Fur family
GNE05_13155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNE05_13170	COG0513	Belongs to the DEAD box helicase family
GNE05_13185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GNE05_13190	COG2384	SAM-dependent methyltransferase
GNE05_13195	COG2010	Cytochrome c
GNE05_13200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GNE05_13205	COG0358	DNA primase activity
GNE05_13220	COG0517	IMP dehydrogenase activity
GNE05_13225	COG0751	glycine-tRNA ligase activity
GNE05_13245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GNE05_13250	COG0295	cytidine deaminase activity
GNE05_13255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GNE05_13265	COG1480	7TM receptor with intracellular HD hydrolase
GNE05_13270	COG1702	phosphate starvation-inducible protein PhoH
GNE05_13275	COG0561	phosphatase activity
GNE05_13290	COG4864	UPF0365 protein
GNE05_13295	COG1030	water channel activity
GNE05_13300	COG1610	YqeY-like protein
GNE05_13310	COG1283	sodium-dependent phosphate transmembrane transporter activity
GNE05_13315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GNE05_13320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GNE05_13350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GNE05_13365	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNE05_13380	COG1466	dna polymerase III delta subunit
GNE05_13395	COG0658	competence protein
GNE05_13395	COG2333	competence protein COMEC
GNE05_13400	COG2131	deaminase
GNE05_13405	COG1555	photosystem II stabilization
GNE05_13405	COG1596	polysaccharide export
GNE05_13410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GNE05_13415	COG2226	methyltransferase
GNE05_13420	COG0799	negative regulation of ribosome biogenesis
GNE05_13425	COG1713	HD superfamily hydrolase involved in NAD metabolism
GNE05_13435	COG1534	Rna-binding protein
GNE05_13440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GNE05_13445	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GNE05_13450	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GNE05_13460	COG2755	lipolytic protein G-D-S-L family
GNE05_13470	COG0398	Pfam SNARE associated Golgi protein
GNE05_13495	COG2207	Transcriptional regulator
GNE05_13495	COG3708	Transcriptional regulator
GNE05_13500	COG0583	DNA-binding transcription factor activity
GNE05_13515	COG0642	Histidine kinase
GNE05_13515	COG5002	protein histidine kinase activity
GNE05_13520	COG0745	RESPONSE REGULATOR receiver
GNE05_13525	COG2311	Membrane
GNE05_13535	COG0454	-acetyltransferase
GNE05_13540	COG0563	adenylate kinase activity
GNE05_13550	COG2814	Major facilitator Superfamily
GNE05_13560	COG0456	acetyltransferase
GNE05_13565	COG2318	DinB family
GNE05_13575	COG0561	phosphatase activity
GNE05_13580	COG0561	phosphatase activity
GNE05_13590	COG1482	cell wall glycoprotein biosynthetic process
GNE05_13595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNE05_13595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNE05_13595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GNE05_13600	COG3711	transcriptional antiterminator
GNE05_13600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNE05_13610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GNE05_13615	COG0583	DNA-binding transcription factor activity
GNE05_13620	COG2814	Major facilitator Superfamily
GNE05_13625	COG2124	cytochrome p450
GNE05_13625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GNE05_13630	COG1309	transcriptional regulator
GNE05_13635	COG2226	methyltransferase
GNE05_13645	COG2116	formate transmembrane transporter activity
GNE05_13650	COG5609	conserved protein (DUF2294)
GNE05_13655	COG3383	formate dehydrogenase (NAD+) activity
GNE05_13660	COG2427	Protein of unknown function (DUF1641)
GNE05_13670	COG0626	cystathionine gamma-synthase activity
GNE05_13675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GNE05_13700	COG0768	penicillin binding
GNE05_13725	COG4122	O-methyltransferase activity
GNE05_13730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GNE05_13745	COG4472	Bacterial protein of unknown function (DUF965)
GNE05_13755	COG0628	permease
GNE05_13760	COG1126	abc transporter atp-binding protein
GNE05_13765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNE05_13770	COG0765	amino acid transport
GNE05_13775	COG0765	amino acid transport
GNE05_13790	COG3881	PFAM PRC-barrel domain
GNE05_13795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GNE05_13800	COG0457	Tetratricopeptide repeat
GNE05_13810	COG1104	cysteine desulfurase activity
GNE05_13815	COG1959	2 iron, 2 sulfur cluster binding
GNE05_13820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GNE05_13825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GNE05_13850	COG3103	Sh3 type 3 domain protein
GNE05_13850	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNE05_13850	COG4991	sh3 domain protein
GNE05_13860	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GNE05_13870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GNE05_13870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GNE05_13875	COG5416	Lipopolysaccharide assembly protein A domain
GNE05_13880	COG0490	domain, Protein
GNE05_13885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GNE05_13885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GNE05_13895	COG2244	polysaccharide biosynthetic process
GNE05_13900	COG2323	membrane
GNE05_13910	COG1862	Preprotein translocase
GNE05_13955	COG1388	LysM domain
GNE05_13965	COG0157	Belongs to the NadC ModD family
GNE05_13970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GNE05_13975	COG1104	cysteine desulfurase activity
GNE05_13980	COG1827	regulation of RNA biosynthetic process
GNE05_13985	COG0077	Prephenate dehydratase
GNE05_14000	COG3290	protein histidine kinase activity
GNE05_14005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GNE05_14010	COG2868	ribosomal protein
GNE05_14020	COG1994	Peptidase M50
GNE05_14025	COG0739	heme binding
GNE05_14030	COG2894	cell division
GNE05_14040	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GNE05_14050	COG1077	Cell shape determining protein MreB Mrl
GNE05_14070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GNE05_14075	COG0285	dihydrofolate synthase activity
GNE05_14080	COG0525	valine-tRNA ligase activity
GNE05_14090	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GNE05_14095	COG1388	LysM domain
GNE05_14105	COG0113	porphobilinogen synthase activity
GNE05_14110	COG1587	Uroporphyrinogen-III synthase
GNE05_14120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GNE05_14140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GNE05_14145	COG0470	DNA polymerase III
GNE05_14145	COG1067	ATP-dependent peptidase activity
GNE05_14160	COG1477	protein flavinylation
GNE05_14160	COG0457	Tetratricopeptide repeat
GNE05_14175	COG0473	3-isopropylmalate dehydrogenase activity
GNE05_14190	COG0440	acetolactate synthase activity
GNE05_14195	COG0028	Belongs to the TPP enzyme family
GNE05_14215	COG0732	type I restriction modification DNA specificity domain
GNE05_14225	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GNE05_14250	COG0622	Phosphoesterase
GNE05_14255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GNE05_14265	COG5401	PFAM Sporulation and spore germination
GNE05_14275	COG1846	Transcriptional regulator
GNE05_14280	COG2197	response regulator
GNE05_14285	COG0824	Thioesterase
GNE05_14290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GNE05_14295	COG1053	succinate dehydrogenase
GNE05_14300	COG2009	succinate dehydrogenase
GNE05_14305	COG1719	4-vinyl reductase, 4VR
GNE05_14310	COG0527	aspartate kinase activity
GNE05_14320	COG3118	belongs to the thioredoxin family
GNE05_14325	COG3534	alpha-L-arabinofuranosidase
GNE05_14330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GNE05_14335	COG2086	electron transfer activity
GNE05_14340	COG1024	Enoyl-CoA hydratase
GNE05_14345	COG1309	transcriptional regulator
GNE05_14350	COG0318	PFAM AMP-dependent synthetase and ligase
GNE05_14360	COG3766	membrane
GNE05_14370	COG1796	DNA polymerase
GNE05_14370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GNE05_14375	COG1286	toxin biosynthetic process
GNE05_14395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNE05_14395	COG0072	phenylalanine-tRNA ligase activity
GNE05_14400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GNE05_14405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GNE05_14415	COG3835	regulator
GNE05_14420	COG0277	FAD linked oxidase domain protein
GNE05_14425	COG0247	lactate metabolic process
GNE05_14430	COG1966	Carbon starvation protein
GNE05_14435	COG3534	alpha-L-arabinofuranosidase
GNE05_14440	COG0395	ABC-type sugar transport system, permease component
GNE05_14445	COG1175	transmembrane transport
GNE05_14450	COG1653	transport
GNE05_14460	COG0647	UMP catabolic process
GNE05_14465	COG0235	Class ii aldolase
GNE05_14470	COG1069	ribulokinase activity
GNE05_14475	COG2160	L-arabinose isomerase activity
GNE05_14480	COG3507	Belongs to the glycosyl hydrolase 43 family
GNE05_14485	COG1363	Peptidase, m42
GNE05_14495	COG3326	Membrane
GNE05_14510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GNE05_14515	COG1346	cytolysis
GNE05_14520	COG1380	Effector of murein hydrolase LrgA
GNE05_14525	COG3279	Response regulator of the LytR AlgR family
GNE05_14530	COG3275	phosphorelay sensor kinase activity
GNE05_14535	COG1011	Hydrolase
GNE05_14550	COG0398	Pfam SNARE associated Golgi protein
GNE05_14555	COG1484	DNA-dependent DNA replication
GNE05_14560	COG3611	Membrane attachment protein
GNE05_14575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GNE05_14580	COG1733	regulation of RNA biosynthetic process
GNE05_14585	COG2814	Major facilitator Superfamily
GNE05_14590	COG0656	L-ascorbic acid biosynthetic process
GNE05_14595	COG0237	dephospho-CoA kinase activity
GNE05_14600	COG1971	Probably functions as a manganese efflux pump
GNE05_14605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GNE05_14610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNE05_14610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GNE05_14615	COG5002	protein histidine kinase activity
GNE05_14620	COG0745	RESPONSE REGULATOR receiver
GNE05_14630	COG0538	isocitrate dehydrogenase activity
GNE05_14635	COG0372	Belongs to the citrate synthase family
GNE05_14640	COG0457	Tetratricopeptide repeat
GNE05_14665	COG5632	N-Acetylmuramoyl-L-alanine amidase
GNE05_14675	COG0628	permease
GNE05_14680	COG3030	protein affecting phage T7 exclusion by the F plasmid
GNE05_14685	COG0469	pyruvate kinase activity
GNE05_14705	COG0281	malic enzyme
GNE05_14710	COG0587	DNA-directed DNA polymerase activity
GNE05_14730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GNE05_14740	COG4109	DRTGG domain
GNE05_14750	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_14765	COG0521	Mo-molybdopterin cofactor biosynthetic process
GNE05_14775	COG0827	DNA restriction-modification system
GNE05_14780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GNE05_14785	COG3874	Sporulation protein YtfJ
GNE05_14795	COG1714	RDD family
GNE05_14800	COG0616	signal peptide processing
GNE05_14805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GNE05_14810	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GNE05_14815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNE05_14830	COG1104	cysteine desulfurase activity
GNE05_14835	COG1114	Component of the transport system for branched-chain amino acids
GNE05_14845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GNE05_14850	COG1309	transcriptional regulator
GNE05_14855	COG1956	GAF domain-containing protein
GNE05_14860	COG2203	Gaf domain
GNE05_14860	COG2199	diguanylate cyclase activity
GNE05_14875	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_14895	COG1017	nitric oxide dioxygenase activity
GNE05_14895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GNE05_14905	COG0693	protein deglycase activity
GNE05_14920	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GNE05_14925	COG1378	Sugar-specific transcriptional regulator TrmB
GNE05_14945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GNE05_14950	COG0454	-acetyltransferase
GNE05_14955	COG0517	IMP dehydrogenase activity
GNE05_14960	COG0123	including yeast histone deacetylase and acetoin utilization protein
GNE05_14965	COG1360	Flagellar Motor Protein
GNE05_14970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GNE05_14975	COG1609	Transcriptional regulator
GNE05_14980	COG1605	Chorismate mutase
GNE05_14980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GNE05_14985	COG3118	belongs to the thioredoxin family
GNE05_14990	COG4980	gas vesicle protein
GNE05_14995	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GNE05_15005	COG1674	ftsk spoiiie
GNE05_15010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GNE05_15020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_15030	COG1363	Peptidase, m42
GNE05_15035	COG5584	Small secreted protein
GNE05_15040	COG0281	malic enzyme
GNE05_15045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GNE05_15060	COG0510	thiamine kinase activity
GNE05_15065	COG1597	lipid kinase activity
GNE05_15075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GNE05_15080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GNE05_15085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNE05_15090	COG2252	PERMEase
GNE05_15095	COG4473	ABC transporter
GNE05_15100	COG1131	(ABC) transporter
GNE05_15105	COG1349	DNA-binding transcription factor activity
GNE05_15110	COG1187	pseudouridine synthase activity
GNE05_15115	COG2244	polysaccharide biosynthetic process
GNE05_15120	COG2081	HI0933 family
GNE05_15125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GNE05_15140	COG1609	Transcriptional regulator
GNE05_15145	COG1653	transport
GNE05_15150	COG1175	transmembrane transport
GNE05_15155	COG0395	ABC-type sugar transport system, permease component
GNE05_15160	COG1486	melibiose metabolic process
GNE05_15170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GNE05_15185	COG1366	Belongs to the anti-sigma-factor antagonist family
GNE05_15185	COG2202	Pas domain
GNE05_15195	COG2814	Major facilitator Superfamily
GNE05_15200	COG5522	Integral membrane protein (intg_mem_TP0381)
GNE05_15205	COG0577	efflux transmembrane transporter activity
GNE05_15210	COG1136	(ABC) transporter
GNE05_15215	COG2205	protein histidine kinase activity
GNE05_15220	COG0745	RESPONSE REGULATOR receiver
GNE05_15225	COG0577	efflux transmembrane transporter activity
GNE05_15230	COG1136	(ABC) transporter
GNE05_15250	COG1131	(ABC) transporter
GNE05_15255	COG1725	Transcriptional regulator
GNE05_15265	COG0640	Transcriptional regulator
GNE05_15270	COG0477	Major facilitator Superfamily
GNE05_15275	COG1242	4 iron, 4 sulfur cluster binding
GNE05_15280	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GNE05_15290	COG0584	glycerophosphoryl diester phosphodiesterase
GNE05_15300	COG2267	carboxylic ester hydrolase activity
GNE05_15305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GNE05_15310	COG1113	amino acid transport
GNE05_15315	COG0367	asparagine synthase
GNE05_15335	COG1506	peptidase
GNE05_15340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GNE05_15345	COG1116	anion transmembrane transporter activity
GNE05_15350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GNE05_15355	COG0494	nUDIX hydrolase
GNE05_15360	COG4824	toxin secretion phage lysis holin
GNE05_15365	COG0783	Belongs to the Dps family
GNE05_15390	COG0288	reversible hydration of carbon dioxide
GNE05_15400	COG1271	oxidase subunit
GNE05_15405	COG1294	oxidase, subunit
GNE05_15415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GNE05_15420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GNE05_15420	COG1321	iron dependent repressor
GNE05_15425	COG1121	(ABC) transporter
GNE05_15430	COG0803	Belongs to the bacterial solute-binding protein 9 family
GNE05_15435	COG4948	Mandelate Racemase Muconate Lactonizing
GNE05_15445	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GNE05_15450	COG0596	Alpha beta hydrolase
GNE05_15460	COG1169	isochorismate synthase
GNE05_15465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GNE05_15470	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GNE05_15595	COG3859	Proton-coupled thiamine transporter YuaJ
GNE05_15655	COG0739	heme binding
GNE05_15655	COG0741	lytic transglycosylase activity
GNE05_15655	COG1196	nuclear chromosome segregation
GNE05_15810	COG1585	Membrane protein implicated in regulation of membrane protease activity
GNE05_15815	COG2318	DinB family
GNE05_15825	COG1454	alcohol dehydrogenase
GNE05_15830	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_15835	COG1510	regulation of RNA biosynthetic process
GNE05_15845	COG0569	domain protein
GNE05_15850	COG1705	Flagellar rod assembly protein muramidase FlgJ
GNE05_15855	COG1017	nitric oxide dioxygenase activity
GNE05_15855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GNE05_15880	COG0628	permease
GNE05_15885	COG0673	inositol 2-dehydrogenase activity
GNE05_15890	COG0693	protein deglycase activity
GNE05_15895	COG0840	transmembrane signaling receptor activity
GNE05_15900	COG0840	transmembrane signaling receptor activity
GNE05_15905	COG0840	transmembrane signaling receptor activity
GNE05_15910	COG0840	transmembrane signaling receptor activity
GNE05_15925	COG2070	2-Nitropropane dioxygenase
GNE05_15930	COG0432	Pfam Uncharacterised protein family UPF0047
GNE05_15935	COG0366	Alpha amylase catalytic
GNE05_15940	COG1253	flavin adenine dinucleotide binding
GNE05_15945	COG2738	Putative neutral zinc metallopeptidase
GNE05_15960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GNE05_15985	COG1335	isochorismatase
GNE05_15990	COG1979	alcohol dehydrogenase
GNE05_15995	COG1979	alcohol dehydrogenase
GNE05_16000	COG2155	Conserved Protein
GNE05_16005	COG1098	S1 RNA binding domain
GNE05_16010	COG0436	Aminotransferase
GNE05_16015	COG1522	sequence-specific DNA binding
GNE05_16020	COG2267	carboxylic ester hydrolase activity
GNE05_16030	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GNE05_16035	COG2205	protein histidine kinase activity
GNE05_16045	COG5018	Exonuclease
GNE05_16050	COG2814	Major facilitator Superfamily
GNE05_16055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNE05_16060	COG3011	Protein conserved in bacteria
GNE05_16070	COG3290	protein histidine kinase activity
GNE05_16075	COG4565	transcriptional regulatory protein
GNE05_16105	COG2111	Na H antiporter
GNE05_16105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GNE05_16110	COG2111	Na H antiporter
GNE05_16115	COG1006	Multisubunit Na H antiporter MnhC subunit
GNE05_16120	COG0651	ATP synthesis coupled electron transport
GNE05_16125	COG1863	multisubunit Na H antiporter MnhE subunit
GNE05_16130	COG2212	antiporter activity
GNE05_16135	COG1320	monovalent cation:proton antiporter activity
GNE05_16140	COG2050	protein possibly involved in aromatic compounds catabolism
GNE05_16145	COG2197	response regulator
GNE05_16150	COG4585	Histidine kinase
GNE05_16160	COG0142	geranyltranstransferase activity
GNE05_16175	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GNE05_16180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GNE05_16185	COG1335	isochorismatase
GNE05_16190	COG5506	Protein of unknown function (DUF1694)
GNE05_16205	COG0628	permease
GNE05_16215	COG1418	mRNA catabolic process
GNE05_16220	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_16230	COG1511	domain protein
GNE05_16235	COG0433	COG0433 Predicted ATPase
GNE05_16235	COG1674	ftsk spoiiie
GNE05_16240	COG4499	WXG100 protein secretion system (Wss), protein YukC
GNE05_16245	COG5417	Belongs to the EsaB family
GNE05_16250	COG4842	Belongs to the WXG100 family
GNE05_16255	COG2508	Transcriptional regulator
GNE05_16255	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GNE05_16260	COG0686	Belongs to the AlaDH PNT family
GNE05_16265	COG5634	Uncharacterized conserved protein (DUF2278)
GNE05_16270	COG3251	PFAM MbtH domain protein
GNE05_16275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GNE05_16280	COG1535	isochorismatase
GNE05_16280	COG3433	isochorismatase activity
GNE05_16285	COG1021	2,3-dihydroxybenzoate-AMP ligase
GNE05_16290	COG1169	isochorismate synthase
GNE05_16295	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_16300	COG2819	hydrolase of the alpha beta superfamily
GNE05_16305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GNE05_16310	COG1268	BioY protein
GNE05_16315	COG2056	Na+-H+ antiporter family
GNE05_16325	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GNE05_16330	COG3584	3D domain protein
GNE05_16345	COG1252	NADH dehydrogenase
GNE05_16370	COG1131	(ABC) transporter
GNE05_16390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GNE05_16395	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GNE05_16400	COG0316	Belongs to the HesB IscA family
GNE05_16410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GNE05_16420	COG1252	NADH dehydrogenase
GNE05_16425	COG4837	Protein of unknown function (DUF1462)
GNE05_16430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GNE05_16435	COG4946	Tricorn protease homolog
GNE05_16435	COG1506	peptidase
GNE05_16435	COG0823	Involved in the tonB-independent uptake of proteins
GNE05_16445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GNE05_16450	COG0460	homoserine dehydrogenase
GNE05_16455	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GNE05_16460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GNE05_16465	COG0647	UMP catabolic process
GNE05_16470	COG2445	Protein of unknown function DUF86
GNE05_16475	COG4470	Protein conserved in bacteria
GNE05_16485	COG0739	heme binding
GNE05_16495	COG0737	Belongs to the 5'-nucleotidase family
GNE05_16500	COG0730	response to heat
GNE05_16505	COG1801	Protein of unknown function DUF72
GNE05_16520	COG2508	Transcriptional regulator
GNE05_16545	COG2814	Major facilitator Superfamily
GNE05_16550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GNE05_16555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GNE05_16560	COG2356	endonuclease I
GNE05_16565	COG3842	ATPase activity
GNE05_16570	COG2188	Transcriptional regulator
GNE05_16575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GNE05_16580	COG0395	ABC-type sugar transport system, permease component
GNE05_16585	COG1175	transmembrane transport
GNE05_16590	COG1653	transport
GNE05_16595	COG2222	sugar isomerase
GNE05_16600	COG0789	Transcriptional regulator
GNE05_16625	COG0322	excinuclease ABC activity
GNE05_16630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GNE05_16635	COG2226	methyltransferase
GNE05_16645	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_16650	COG0719	Fe-S assembly protein
GNE05_16655	COG0822	iron-sulfur transferase activity
GNE05_16660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GNE05_16665	COG0719	Fe-S assembly protein
GNE05_16670	COG0396	ATPase activity
GNE05_16680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GNE05_16685	COG1464	Belongs to the NlpA lipoprotein family
GNE05_16690	COG2011	ABC-type metal ion transport system permease component
GNE05_16695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GNE05_16705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GNE05_16710	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GNE05_16725	COG1393	Belongs to the ArsC family
GNE05_16730	COG1960	acyl-CoA dehydrogenase activity
GNE05_16735	COG0183	Belongs to the thiolase family
GNE05_16740	COG1250	3-hydroxyacyl-CoA dehydrogenase
GNE05_16740	COG1024	Enoyl-CoA hydratase
GNE05_16760	COG5577	PFAM Coat F domain
GNE05_16765	COG1846	Transcriptional regulator
GNE05_16770	COG0477	Major facilitator Superfamily
GNE05_16775	COG0583	DNA-binding transcription factor activity
GNE05_16795	COG1120	ATPase activity
GNE05_16810	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_16815	COG0783	Belongs to the Dps family
GNE05_16820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNE05_16825	COG0745	RESPONSE REGULATOR receiver
GNE05_16830	COG2205	protein histidine kinase activity
GNE05_16830	COG2770	Histidine kinase
GNE05_16840	COG1309	transcriptional regulator
GNE05_16845	COG0114	fumarate hydratase activity
GNE05_16855	COG0697	spore germination
GNE05_16860	COG0814	amino acid
GNE05_16870	COG2197	response regulator
GNE05_16875	COG4585	Histidine kinase
GNE05_16880	COG4758	membrane
GNE05_16885	COG3595	metallopeptidase activity
GNE05_16890	COG1842	Phage shock protein A
GNE05_16895	COG4758	membrane
GNE05_16900	COG2814	Major facilitator Superfamily
GNE05_16905	COG2096	Adenosyltransferase
GNE05_16910	COG1120	ATPase activity
GNE05_16915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_16920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNE05_16925	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_16930	COG3386	PFAM SMP-30 Gluconolaconase
GNE05_16935	COG2205	protein histidine kinase activity
GNE05_16940	COG0745	RESPONSE REGULATOR receiver
GNE05_16950	COG1191	sigma factor activity
GNE05_16960	COG2140	Oxalate decarboxylase
GNE05_16970	COG1120	ATPase activity
GNE05_16975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_16980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_16985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNE05_16990	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GNE05_16995	COG0531	amino acid
GNE05_17005	COG1988	membrane-bound metal-dependent
GNE05_17010	COG1368	sulfuric ester hydrolase activity
GNE05_17015	COG1910	domain protein
GNE05_17020	COG0725	ABC transporter, periplasmic molybdate-binding protein
GNE05_17025	COG4149	molybdate abc transporter
GNE05_17030	COG2197	response regulator
GNE05_17035	COG3850	Histidine kinase
GNE05_17040	COG1131	(ABC) transporter
GNE05_17050	COG0842	Transport permease protein
GNE05_17055	COG0656	L-ascorbic acid biosynthetic process
GNE05_17075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GNE05_17080	COG3973	AAA domain
GNE05_17085	COG2860	membrane
GNE05_17095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GNE05_17100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GNE05_17105	COG2217	Heavy metal translocating P-type atpase
GNE05_17110	COG2217	Heavy metal translocating P-type atpase
GNE05_17115	COG2608	mercury ion transmembrane transporter activity
GNE05_17120	COG1937	Protein conserved in bacteria
GNE05_17125	COG0673	inositol 2-dehydrogenase activity
GNE05_17135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNE05_17140	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GNE05_17145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNE05_17150	COG1126	abc transporter atp-binding protein
GNE05_17155	COG0765	amino acid transport
GNE05_17160	COG0765	amino acid transport
GNE05_17165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNE05_17170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GNE05_17175	COG0454	-acetyltransferase
GNE05_17180	COG0583	DNA-binding transcription factor activity
GNE05_17185	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_17190	COG2732	(Barnase) inhibitor
GNE05_17195	COG2732	(Barnase) inhibitor
GNE05_17210	COG0557	exoribonuclease II activity
GNE05_17215	COG1647	Serine aminopeptidase, S33
GNE05_17220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GNE05_17225	COG1476	TRANSCRIPTIONal
GNE05_17230	COG1396	sequence-specific DNA binding
GNE05_17235	COG1396	sequence-specific DNA binding
GNE05_17240	COG1733	regulation of RNA biosynthetic process
GNE05_17265	COG1131	(ABC) transporter
GNE05_17305	COG1174	glycine betaine transport
GNE05_17310	COG1732	Glycine betaine
GNE05_17315	COG1174	glycine betaine transport
GNE05_17320	COG1125	glycine betaine transport
GNE05_17320	COG0517	IMP dehydrogenase activity
GNE05_17325	COG1510	regulation of RNA biosynthetic process
GNE05_17330	COG1174	glycine betaine transport
GNE05_17335	COG1732	Glycine betaine
GNE05_17340	COG1174	glycine betaine transport
GNE05_17345	COG1125	glycine betaine transport
GNE05_17345	COG0517	IMP dehydrogenase activity
GNE05_17350	COG1510	regulation of RNA biosynthetic process
GNE05_17355	COG2095	MarC family integral membrane protein
GNE05_17360	COG3064	Membrane
GNE05_17365	COG4640	response to antibiotic
GNE05_17370	COG0456	acetyltransferase
GNE05_17390	COG0126	phosphoglycerate kinase activity
GNE05_17395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GNE05_17400	COG2390	Transcriptional regulator
GNE05_17405	COG2814	Major facilitator Superfamily
GNE05_17410	COG1609	Transcriptional regulator
GNE05_17415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNE05_17420	COG0583	DNA-binding transcription factor activity
GNE05_17425	COG0697	spore germination
GNE05_17430	COG1113	amino acid transport
GNE05_17435	COG1737	Transcriptional regulator
GNE05_17440	COG1070	Carbohydrate kinase
GNE05_17465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNE05_17470	COG2186	Transcriptional regulator
GNE05_17475	COG1620	l-lactate permease
GNE05_17480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GNE05_17490	COG5039	Polysaccharide pyruvyl transferase
GNE05_17495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GNE05_17500	COG0110	maltose O-acetyltransferase activity
GNE05_17505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GNE05_17510	COG2244	polysaccharide biosynthetic process
GNE05_17515	COG1216	Glycosyl transferase, family 2
GNE05_17520	COG5039	Polysaccharide pyruvyl transferase
GNE05_17525	COG1216	Glycosyl transferase, family 2
GNE05_17535	COG0438	transferase activity, transferring glycosyl groups
GNE05_17540	COG1215	transferase activity, transferring glycosyl groups
GNE05_17545	COG0438	transferase activity, transferring glycosyl groups
GNE05_17550	COG1086	Polysaccharide biosynthesis protein
GNE05_17555	COG0489	protein tyrosine kinase activity
GNE05_17560	COG3944	biosynthesis protein
GNE05_17565	COG1396	sequence-specific DNA binding
GNE05_17570	COG2272	Belongs to the type-B carboxylesterase lipase family
GNE05_17580	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GNE05_17585	COG2364	Membrane
GNE05_17590	COG0456	acetyltransferase
GNE05_17595	COG3479	Phenolic acid decarboxylase
GNE05_17635	COG2223	nitrite transmembrane transporter activity
GNE05_17640	COG1609	Transcriptional regulator
GNE05_17650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GNE05_17655	COG0366	Alpha amylase catalytic
GNE05_17660	COG1554	hydrolase, family 65, central catalytic
GNE05_17665	COG5521	maltodextrose utilization protein MalA
GNE05_17670	COG3833	ABC-type maltose transport systems, permease component
GNE05_17675	COG1175	transmembrane transport
GNE05_17680	COG2182	Extracellular solute-binding protein
GNE05_17685	COG0366	Alpha amylase catalytic
GNE05_17690	COG1609	Transcriptional regulator
GNE05_17695	COG1611	Belongs to the LOG family
GNE05_17700	COG1694	Mazg nucleotide pyrophosphohydrolase
GNE05_17705	COG0659	secondary active sulfate transmembrane transporter activity
GNE05_17710	COG0288	reversible hydration of carbon dioxide
GNE05_17715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GNE05_17720	COG4290	ribonuclease
GNE05_17725	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GNE05_17730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNE05_17740	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GNE05_17750	COG1051	belongs to the nudix hydrolase family
GNE05_17755	COG0492	ferredoxin-NADP+ reductase activity
GNE05_17760	COG3883	PFAM NLP P60 protein
GNE05_17760	COG0791	NLP P60 protein
GNE05_17765	COG0457	Tetratricopeptide repeat
GNE05_17770	COG5002	protein histidine kinase activity
GNE05_17775	COG0745	RESPONSE REGULATOR receiver
GNE05_17780	COG1132	(ABC) transporter
GNE05_17785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GNE05_17785	COG0140	phosphoribosyl-ATP diphosphatase activity
GNE05_17810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GNE05_17825	COG4990	cell redox homeostasis
GNE05_17830	COG0110	maltose O-acetyltransferase activity
GNE05_17850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GNE05_17860	COG2188	Transcriptional regulator
GNE05_17865	COG1309	transcriptional regulator
GNE05_17870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GNE05_17875	COG1950	PFAM Membrane protein of
GNE05_17880	COG1983	PspC domain protein
GNE05_17885	COG3595	metallopeptidase activity
GNE05_17900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GNE05_17910	COG4897	Protein conserved in bacteria
GNE05_17915	COG0574	Belongs to the PEP-utilizing enzyme family
GNE05_17915	COG3848	Pyruvate phosphate dikinase
GNE05_17920	COG1309	transcriptional regulator
GNE05_17925	COG2814	Major facilitator Superfamily
GNE05_17940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNE05_17950	COG3409	Peptidoglycan-binding domain 1 protein
GNE05_17950	COG0793	Belongs to the peptidase S41A family
GNE05_17955	COG3420	alginic acid biosynthetic process
GNE05_17960	COG2177	Part of the ABC transporter FtsEX involved in
GNE05_17965	COG2884	Cell division ATP-binding protein ftsE
GNE05_17970	COG2010	Cytochrome c
GNE05_17975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNE05_17990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GNE05_18005	COG1516	flagellar protein fliS
GNE05_18010	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GNE05_18015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GNE05_18035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GNE05_18040	COG4786	Flagellar basal body rod
GNE05_18040	COG1256	bacterial-type flagellum assembly
GNE05_18045	COG3418	PFAM FlgN family protein
GNE05_18050	COG2747	anti-sigma28 factor FlgM
GNE05_18060	COG1040	competence protein
GNE05_18070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GNE05_18075	COG1307	EDD domain protein, DegV family
GNE05_18080	COG2197	response regulator
GNE05_18085	COG4585	Histidine kinase
GNE05_18090	COG1739	Uncharacterized protein family UPF0029
GNE05_18095	COG1316	TRANSCRIPTIONal
GNE05_18100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GNE05_18105	COG0438	transferase activity, transferring glycosyl groups
GNE05_18110	COG1215	transferase activity, transferring glycosyl groups
GNE05_18115	COG3206	protein involved in exopolysaccharide biosynthesis
GNE05_18120	COG3307	-O-antigen
GNE05_18125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GNE05_18130	COG0438	transferase activity, transferring glycosyl groups
GNE05_18130	COG0297	glycogen (starch) synthase activity
GNE05_18135	COG2244	polysaccharide biosynthetic process
GNE05_18145	COG0860	N-Acetylmuramoyl-L-alanine amidase
GNE05_18145	COG2247	cell wall binding repeat
GNE05_18150	COG2247	cell wall binding repeat
GNE05_18150	COG2385	sporulation resulting in formation of a cellular spore
GNE05_18160	COG1316	TRANSCRIPTIONal
GNE05_18165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GNE05_18170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GNE05_18175	COG1134	teichoic acid transport
GNE05_18180	COG1682	transport, permease protein
GNE05_18190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GNE05_18195	COG0438	transferase activity, transferring glycosyl groups
GNE05_18200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GNE05_18205	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GNE05_18210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GNE05_18215	COG4193	domain, Protein
GNE05_18220	COG1482	cell wall glycoprotein biosynthetic process
GNE05_18225	COG0697	spore germination
GNE05_18230	COG0814	amino acid
GNE05_18240	COG1215	transferase activity, transferring glycosyl groups
GNE05_18245	COG2814	Major facilitator Superfamily
GNE05_18250	COG1316	TRANSCRIPTIONal
GNE05_18255	COG0561	phosphatase activity
GNE05_18260	COG2433	Pfam Transposase IS66
GNE05_18265	COG0791	NLP P60 protein
GNE05_18275	COG2843	Capsule synthesis protein
GNE05_18285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GNE05_18290	COG0697	spore germination
GNE05_18295	COG0814	amino acid
GNE05_18305	COG1609	Transcriptional regulator
GNE05_18310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GNE05_18320	COG1129	ABC transporter
GNE05_18325	COG1172	Belongs to the binding-protein-dependent transport system permease family
GNE05_18330	COG1879	ABC-type sugar transport system periplasmic component
GNE05_18335	COG3103	Sh3 type 3 domain protein
GNE05_18340	COG2249	NAD(P)H dehydrogenase (quinone) activity
GNE05_18345	COG3527	Alpha-acetolactate decarboxylase
GNE05_18350	COG0028	Belongs to the TPP enzyme family
GNE05_18355	COG0583	DNA-binding transcription factor activity
GNE05_18360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GNE05_18375	COG5337	Spore coat protein CotH
GNE05_18385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GNE05_18395	COG0405	Gamma-glutamyltransferase
GNE05_18400	COG1522	sequence-specific DNA binding
GNE05_18405	COG2059	Chromate
GNE05_18410	COG2059	Chromate
GNE05_18420	COG0655	NAD(P)H dehydrogenase (quinone) activity
GNE05_18425	COG0583	DNA-binding transcription factor activity
GNE05_18475	COG5444	nuclease activity
GNE05_18490	COG3878	Protein conserved in bacteria
GNE05_18495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GNE05_18500	COG4464	protein tyrosine phosphatase activity
GNE05_18505	COG0489	protein tyrosine kinase activity
GNE05_18510	COG3944	biosynthesis protein
GNE05_18520	COG4715	Zinc finger, swim domain protein
GNE05_18525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GNE05_18530	COG0561	phosphatase activity
GNE05_18535	COG1349	DNA-binding transcription factor activity
GNE05_18540	COG0629	single-stranded DNA binding
GNE05_18565	COG0457	Tetratricopeptide repeat
GNE05_18570	COG4786	Flagellar basal body rod
GNE05_18575	COG4786	Flagellar basal body rod
GNE05_18580	COG1077	Cell shape determining protein MreB Mrl
GNE05_18585	COG1609	Transcriptional regulator
GNE05_18590	COG1846	Transcriptional regulator
GNE05_18595	COG2814	Major facilitator Superfamily
GNE05_18600	COG1953	Uracil, thiamine, allantoin
GNE05_18605	COG0477	Major facilitator Superfamily
GNE05_18610	COG1335	isochorismatase
GNE05_18615	COG0004	ammonium transporteR
GNE05_18620	COG0347	Belongs to the P(II) protein family
GNE05_18625	COG0772	Belongs to the SEDS family
GNE05_18630	COG0671	phosphoesterase, PA-phosphatase related
GNE05_18640	COG0739	heme binding
GNE05_18645	COG1247	-acetyltransferase
GNE05_18660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GNE05_18670	COG0726	polysaccharide deacetylase
GNE05_18675	COG1959	2 iron, 2 sulfur cluster binding
GNE05_18690	COG0831	urea catabolic process
GNE05_18700	COG1994	Peptidase M50
GNE05_18705	COG0457	Tetratricopeptide repeat
GNE05_18715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GNE05_18720	COG2304	oxidoreductase activity
GNE05_18725	COG2304	oxidoreductase activity
GNE05_18730	COG2385	sporulation resulting in formation of a cellular spore
GNE05_18735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GNE05_18745	COG4836	Membrane
GNE05_18815	COG0698	ribose 5-phosphate isomerase
GNE05_18820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GNE05_18830	COG0009	L-threonylcarbamoyladenylate synthase
GNE05_18835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GNE05_18855	COG2890	protein-(glutamine-N5) methyltransferase activity
GNE05_18860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GNE05_18865	COG0346	lactoylglutathione lyase activity
GNE05_18870	COG0789	Transcriptional regulator
GNE05_18875	COG0679	Auxin Efflux Carrier
GNE05_18880	COG0281	malic enzyme
GNE05_18895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GNE05_18900	COG1494	fructose-1,6-bisphosphatase
GNE05_18905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GNE05_18915	COG0191	fructose-bisphosphate aldolase activity
GNE05_18920	COG2204	response regulator
GNE05_18925	COG4821	SIS domain
GNE05_18940	COG0247	lactate metabolic process
GNE05_18940	COG2181	nitrate reductase activity
GNE05_18945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GNE05_18960	COG1132	(ABC) transporter
GNE05_18965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GNE05_18975	COG2181	nitrate reductase activity
GNE05_18980	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GNE05_18985	COG1140	nitrate reductase beta subunit
GNE05_18990	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GNE05_18995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNE05_19005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GNE05_19010	COG2223	nitrite transmembrane transporter activity
GNE05_19020	COG4506	Protein conserved in bacteria
GNE05_19025	COG0457	Tetratricopeptide repeat
GNE05_19070	COG0010	Belongs to the arginase family
GNE05_19075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GNE05_19080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GNE05_19095	COG1994	Peptidase M50
GNE05_19100	COG1942	4-Oxalocrotonate Tautomerase
GNE05_19105	COG1846	Transcriptional regulator
GNE05_19115	COG0531	amino acid
GNE05_19120	COG3465	dGTPase activity
GNE05_19125	COG1078	dGTPase activity
GNE05_19140	COG1695	Transcriptional regulator
GNE05_19150	COG1131	(ABC) transporter
GNE05_19155	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GNE05_19185	COG0583	DNA-binding transcription factor activity
GNE05_19190	COG2855	membrane
GNE05_19195	COG0280	phosphate acetyltransferase
GNE05_19225	COG3118	belongs to the thioredoxin family
GNE05_19230	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_19235	COG0436	Aminotransferase
GNE05_19265	COG2814	Major facilitator Superfamily
GNE05_19270	COG2814	Major facilitator Superfamily
GNE05_19275	COG0833	amino acid
GNE05_19280	COG4187	Peptidase family M20/M25/M40
GNE05_19285	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_19290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GNE05_19295	COG2205	protein histidine kinase activity
GNE05_19300	COG0745	RESPONSE REGULATOR receiver
GNE05_19315	COG1131	(ABC) transporter
GNE05_19320	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GNE05_19325	COG1091	dTDP-4-dehydrorhamnose reductase activity
GNE05_19330	COG1088	dTDP-glucose 4,6-dehydratase activity
GNE05_19335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GNE05_19340	COG3980	spore coat polysaccharide biosynthesis protein
GNE05_19345	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GNE05_19350	COG2089	acid synthase
GNE05_19355	COG0456	acetyltransferase
GNE05_19360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GNE05_19365	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GNE05_19370	COG0463	Glycosyl transferase, family 2
GNE05_19380	COG2363	Small membrane protein
GNE05_19385	COG2233	PERMEase
GNE05_19400	COG1216	Glycosyl transferase, family 2
GNE05_19415	COG1695	Transcriptional regulator
GNE05_19420	COG0351	phosphomethylpyrimidine kinase
GNE05_19430	COG1621	beta-fructofuranosidase activity
GNE05_19435	COG1263	PTS System
GNE05_19435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GNE05_19440	COG3711	transcriptional antiterminator
GNE05_19450	COG1404	Belongs to the peptidase S8 family
GNE05_19455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GNE05_19460	COG0778	Nitroreductase
GNE05_19465	COG0772	Belongs to the SEDS family
GNE05_19470	COG0454	-acetyltransferase
GNE05_19490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GNE05_19495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GNE05_19500	COG2261	transglycosylase associated protein
GNE05_19510	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GNE05_19515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GNE05_19520	COG2246	polysaccharide biosynthetic process
GNE05_19525	COG1309	transcriptional regulator
GNE05_19545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GNE05_19550	COG2837	iron assimilation
GNE05_19555	COG2822	iron ion transport
GNE05_19570	COG0583	DNA-binding transcription factor activity
GNE05_19580	COG1346	cytolysis
GNE05_19585	COG4895	conserved protein (DUF2196)
GNE05_19590	COG0789	Transcriptional regulator
GNE05_19595	COG5504	Zn-dependent protease
GNE05_19600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GNE05_19605	COG0346	lactoylglutathione lyase activity
GNE05_19610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GNE05_19615	COG1404	Belongs to the peptidase S8 family
GNE05_19620	COG1442	glycosyl transferase family 8
GNE05_19625	COG1846	Transcriptional regulator
GNE05_19630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GNE05_19635	COG2357	RelA SpoT domain protein
GNE05_19640	COG1575	Belongs to the MenA family. Type 1 subfamily
GNE05_19655	COG1696	Membrane protein involved in D-alanine export
GNE05_19665	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GNE05_19670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GNE05_19675	COG1486	melibiose metabolic process
GNE05_19680	COG1447	Phosphotransferase system cellobiose-specific component IIA
GNE05_19685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GNE05_19690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GNE05_19695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GNE05_19695	COG3711	transcriptional antiterminator
GNE05_19705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_19710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GNE05_19720	COG0640	Transcriptional regulator
GNE05_19725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GNE05_19730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GNE05_19735	COG1447	Phosphotransferase system cellobiose-specific component IIA
GNE05_19740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GNE05_19745	COG2723	6-phospho-beta-galactosidase activity
GNE05_19750	COG1940	carbohydrate kinase activity
GNE05_19755	COG1482	cell wall glycoprotein biosynthetic process
GNE05_19765	COG0753	catalase activity
GNE05_19770	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GNE05_19775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GNE05_19780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GNE05_19785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GNE05_19790	COG4988	ABC transporter
GNE05_19795	COG1294	oxidase, subunit
GNE05_19800	COG1271	oxidase subunit
GNE05_19805	COG3493	citrate carrier protein
GNE05_19810	COG0726	polysaccharide deacetylase
GNE05_19815	COG3842	ATPase activity
GNE05_19820	COG2508	Transcriptional regulator
GNE05_19825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNE05_19835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GNE05_19845	COG4894	glucomannan catabolic process
GNE05_19850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GNE05_19855	COG0500	methyltransferase
GNE05_19860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GNE05_19875	COG0753	catalase activity
GNE05_19875	COG0693	protein deglycase activity
GNE05_19880	COG2851	Citrate transporter
GNE05_19885	COG2273	Hydrolase Family 16
GNE05_19890	COG3711	transcriptional antiterminator
GNE05_19895	COG2270	Major facilitator Superfamily
GNE05_19900	COG0513	Belongs to the DEAD box helicase family
GNE05_19965	COG0697	spore germination
GNE05_19970	COG0589	response to stress
GNE05_20030	COG3507	Belongs to the glycosyl hydrolase 43 family
GNE05_20055	COG0010	Belongs to the arginase family
GNE05_20060	COG0833	amino acid
GNE05_20065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GNE05_20070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GNE05_20080	COG2390	Transcriptional regulator
GNE05_20085	COG0561	phosphatase activity
GNE05_20115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GNE05_20120	COG5294	Protein conserved in bacteria
GNE05_20125	COG0577	efflux transmembrane transporter activity
GNE05_20130	COG1136	(ABC) transporter
GNE05_20135	COG2205	protein histidine kinase activity
GNE05_20140	COG0745	RESPONSE REGULATOR receiver
GNE05_20145	COG2205	protein histidine kinase activity
GNE05_20150	COG0745	RESPONSE REGULATOR receiver
GNE05_20180	COG1082	Xylose isomerase domain protein TIM barrel
GNE05_20190	COG2814	Major facilitator Superfamily
GNE05_20220	COG1349	DNA-binding transcription factor activity
GNE05_20225	COG0667	Aldo Keto reductase
GNE05_20230	COG2814	Major facilitator Superfamily
GNE05_20245	COG1028	Short-chain dehydrogenase reductase Sdr
GNE05_20250	COG2197	response regulator
GNE05_20255	COG4585	Histidine kinase
GNE05_20260	COG3239	Fatty acid desaturase
GNE05_20270	COG1309	transcriptional regulator
GNE05_20275	COG1012	belongs to the aldehyde dehydrogenase family
GNE05_20280	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GNE05_20290	COG0640	Transcriptional regulator
GNE05_20295	COG2814	Major facilitator Superfamily
GNE05_20300	COG1714	RDD family
GNE05_20310	COG0501	Belongs to the peptidase M48B family
GNE05_20315	COG1715	Restriction endonuclease
GNE05_20320	COG0450	alkyl hydroperoxide reductase
GNE05_20325	COG3634	alkyl hydroperoxide reductase activity
GNE05_20330	COG3177	Filamentation induced by cAMP protein fic
GNE05_20335	COG1113	amino acid transport
GNE05_20345	COG2080	2 iron, 2 sulfur cluster binding
GNE05_20360	COG2068	MobA-Related Protein
GNE05_20365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GNE05_20420	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GNE05_20425	COG0667	Aldo Keto reductase
GNE05_20430	COG0456	acetyltransferase
GNE05_20435	COG0457	Tetratricopeptide repeat
GNE05_20440	COG0010	Belongs to the arginase family
GNE05_20445	COG0833	amino acid
GNE05_20450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GNE05_20455	COG5658	integral membrane protein
GNE05_20460	COG0640	Transcriptional regulator
GNE05_20465	COG3829	transcription factor binding
GNE05_20475	COG0488	(ABC) transporter
GNE05_20490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GNE05_20495	COG3850	Histidine kinase
GNE05_20495	COG5002	protein histidine kinase activity
GNE05_20510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GNE05_20515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GNE05_20520	COG4853	Protein conserved in bacteria
GNE05_20525	COG4863	YycH protein
GNE05_20530	COG5002	protein histidine kinase activity
GNE05_20535	COG0745	RESPONSE REGULATOR receiver
GNE05_20565	COG0346	lactoylglutathione lyase activity
GNE05_20570	COG0305	Participates in initiation and elongation during chromosome replication
GNE05_20585	COG3093	addiction module antidote protein HigA
GNE05_20590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GNE05_20605	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GNE05_20610	COG0438	transferase activity, transferring glycosyl groups
GNE05_20620	COG2112	serine threonine protein kinase
GNE05_20630	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GNE05_20635	COG4241	membrane
GNE05_20645	COG5577	PFAM Coat F domain
GNE05_20650	COG1733	regulation of RNA biosynthetic process
GNE05_20660	COG0697	spore germination
GNE05_20665	COG1621	beta-fructofuranosidase activity
GNE05_20670	COG1621	beta-fructofuranosidase activity
GNE05_20680	COG2318	DinB family
GNE05_20685	COG2211	Major facilitator Superfamily
GNE05_20690	COG0697	spore germination
GNE05_20700	COG0778	Nitroreductase
GNE05_20705	COG1846	Transcriptional regulator
GNE05_20710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GNE05_20715	COG1846	Transcriptional regulator
GNE05_20720	COG2153	protein acetylation
GNE05_20730	COG0546	phosphoglycolate phosphatase activity
GNE05_20760	COG1404	Belongs to the peptidase S8 family
GNE05_20770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GNE05_20775	COG0697	spore germination
GNE05_20780	COG1331	Highly conserved protein containing a thioredoxin domain
GNE05_20785	COG1266	CAAX protease self-immunity
GNE05_20790	COG0477	Major facilitator Superfamily
GNE05_20790	COG2814	Major facilitator Superfamily
GNE05_20795	COG0346	lactoylglutathione lyase activity
GNE05_20800	COG1609	Transcriptional regulator
GNE05_20810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GNE05_20815	COG2169	Transcriptional regulator
GNE05_20825	COG0629	single-stranded DNA binding
GNE05_20835	COG0012	GTP binding
GNE05_20840	COG0243	molybdopterin cofactor binding
GNE05_20845	COG4481	Protein conserved in bacteria
GNE05_20850	COG3949	Membrane
GNE05_20865	COG1475	DNA binding
GNE05_20870	COG1192	Involved in chromosome partitioning
GNE05_20895	COG1847	R3H domain protein
GNE05_20900	COG0706	membrane insertase activity