locus-tag class description DN399_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN399_00015 ENOG410848D S4 domain protein YaaA DN399_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN399_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DN399_00100 ENOG4105ZMH deoxynucleoside kinase DN399_00110 ENOG4105GTG Isochorismatase DN399_00120 ENOG4108Z6B deaminase DN399_00130 ENOG4105C6E dna polymerase iii DN399_00150 ENOG41067KS pro-sigma K processing DN399_00185 ENOG4105CXN decarboxylase DN399_00195 ENOG4105FA2 dna polymerase iii DN399_00200 ENOG4105MA4 psp1 domain protein DN399_00210 ENOG41060K3 Methyltransferase DN399_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DN399_00225 ENOG4105KRN Transcriptional regulator, abrb family DN399_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN399_00235 ENOG4105F8V Hydrolase, tatD family DN399_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DN399_00250 ENOG4105XFA sporulation peptidase YabG DN399_00255 ENOG4105W42 Veg protein DN399_00270 ENOG4105DFT pur operon repressor DN399_00275 ENOG4105KME endoribonuclease L-psp DN399_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DN399_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DN399_00305 ENOG4108JA2 transcriptioN-repair coupling factor DN399_00310 ENOG4108M14 stage v sporulation protein t DN399_00320 ENOG4108IY2 MazG family DN399_00325 ENOG41082I2 s4 domain protein DN399_00330 ENOG4105VYY sporulation protein yabp DN399_00345 ENOG41060GV RNA binding s1 domain protein DN399_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DN399_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN399_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DN399_00390 ENOG4105C6T cysteine synthase DN399_00395 ENOG4105CRQ synthase (Component I) DN399_00400 ENOG4105DDQ anthranilate synthase DN399_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DN399_00410 ENOG4105EEI dihydropteroate synthase DN399_00415 ENOG4105KRF dihydroneopterin aldolase DN399_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DN399_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DN399_00520 ENOG4108Z0C Uvrb UvrC protein DN399_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DN399_00545 ENOG4105CTP PilT protein domain protein DN399_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DN399_00565 ENOG4105D7W serine acetyltransferase DN399_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 DN399_00585 ENOG4105M0M Tetracycline resistance protein DN399_00590 ENOG4105QIV RNA polymerase DN399_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DN399_00630 ENOG4107Y49 methyltransferase DN399_00645 ENOG4105XPM ribosomal protein DN399_00755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DN399_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN399_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN399_00800 ENOG41067V7 50S ribosomal protein L36 DN399_00825 ENOG4108JJB ABC transporter DN399_00830 ENOG4108JJB ABC transporter DN399_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DN399_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN399_00865 ENOG4105D1F ATP-binding protein DN399_00880 ENOG4108NMV polysaccharide deacetylase DN399_00960 ENOG4105C8B TIGR00159 family DN399_00965 ENOG4107U5W ybbr family DN399_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DN399_01005 ENOG4108PSK reductase DN399_01010 ENOG4108UMI ABC transporter, permease DN399_01015 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DN399_01020 ENOG4105D01 (LipO)protein DN399_01025 ENOG4105CB2 alcohol dehydrogenase DN399_01035 ENOG4105IQ5 FAD linked oxidase domain protein DN399_01050 ENOG4105C2C drug resistance transporter, Bcr CflA DN399_01065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN399_01070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN399_01075 ENOG4105C3U ABC transporter DN399_01080 ENOG4108JQ7 (ABC) transporter DN399_01110 ENOG4108J59 Extracellular solute-binding protein, family 5 DN399_01115 ENOG4108J59 Extracellular solute-binding protein, family 5 DN399_01125 ENOG4105II7 pyrroline-5-carboxylate reductase DN399_01135 ENOG4105E0C molybdate abc transporter DN399_01140 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DN399_01145 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DN399_01155 ENOG4105EGI Transcriptional regulator DN399_01175 ENOG4105F6E Acyl-transferase DN399_01195 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN399_01210 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DN399_01230 ENOG4105C5H ABC transporter DN399_01245 ENOG4105DEF Extracellular solute-binding protein, family 5 DN399_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN399_01260 ENOG4105C3U ABC transporter DN399_01265 ENOG4108JQ7 (ABC) transporter DN399_01270 ENOG410667J hydrolase DN399_01300 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DN399_01305 ENOG4105ERH Fumarylacetoacetate hydrolase DN399_01315 ENOG4105CUB amino acid DN399_01320 ENOG4108SC4 )-transporter DN399_01325 ENOG4105CPF Cell wall formation (By similarity) DN399_01330 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DN399_01355 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DN399_01360 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN399_01370 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DN399_01475 ENOG4105K8N protein family UPF0079, ATPase DN399_01480 ENOG41072GX Peptidase M22 Glycoprotease DN399_01485 ENOG410801F ribosomal-protein-alanine acetyltransferase DN399_01490 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DN399_01495 ENOG4105C5H ABC transporter DN399_01510 ENOG4108TYN CAAX amino terminal protease family protein DN399_01530 ENOG4105C7N Xanthine uracil vitamin C permease DN399_01540 ENOG4105BZU Histidine kinase DN399_01570 ENOG4107ZXU DSBA oxidoreductase DN399_01620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN399_01650 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN399_01660 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DN399_01690 ENOG4105SX7 Transporter DN399_01720 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DN399_01725 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DN399_01730 ENOG4105C83 adenylosuccinate lyase DN399_01740 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DN399_01765 ENOG4108V3E phosphoribosylglycinamide formyltransferase DN399_01775 ENOG4105C12 Phosphoribosylglycinamide synthetase DN399_01805 ENOG4105C4R Atp-dependent dna helicase DN399_01810 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DN399_01830 ENOG4108W2Y isochorismatase DN399_01835 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DN399_01840 ENOG4108UMI ABC transporter, permease DN399_01845 ENOG4105D01 (LipO)protein DN399_01865 ENOG410834F Transcriptional regulator DN399_01870 ENOG4107I77 yiaA/B two helix domain DN399_01880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN399_01890 ENOG4105CBD Diacylglycerol kinase DN399_01900 ENOG4108JPW Aminotransferase DN399_01910 ENOG4105C26 Dehydrogenase DN399_01915 ENOG4105KPY Small multidrug resistance protein DN399_01940 ENOG4105D9N nucleoside DN399_01945 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DN399_01955 ENOG4108W15 Protein of unknown function (DUF1456) DN399_01975 ENOG4105DTQ mandelate racemase muconate lactonizing DN399_01985 ENOG4105DFD Na H antiporter DN399_02005 ENOG4105D3R alkyl hydroperoxide reductase DN399_02010 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DN399_02015 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DN399_02020 ENOG4107W7X Aldolase DN399_02025 ENOG4105EHG Permease protein DN399_02030 ENOG4105DQ5 transport system permease protein DN399_02035 ENOG4108V5C ABC transporter DN399_02045 ENOG4105CAY ferredoxin--nadp reductase DN399_02065 ENOG4106UIA DN399_02070 ENOG4106UIA DN399_02085 ENOG4105BZU Histidine kinase DN399_02105 ENOG410756H nucleotidyltransferase DN399_02110 ENOG4105D2S major facilitator superfamily DN399_02125 ENOG4105E5Q amino acid AbC transporter DN399_02130 ENOG4105EAB amino acid AbC transporter DN399_02140 ENOG4105C8Q Methyl-accepting chemotaxis DN399_02155 ENOG4105DBV ornithine carbamoyltransferase DN399_02165 ENOG4105C5B carbamate kinase DN399_02170 ENOG4108W63 CRP FNR family transcriptional regulator DN399_02180 ENOG4105DNP FAD linked oxidase domain protein DN399_02190 ENOG4105CI1 PTS System DN399_02205 ENOG4105C9U ATP-dependent DNA helicase RecQ DN399_02220 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DN399_02240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN399_02245 ENOG4105D2X ABC transporter substrate-binding protein DN399_02285 ENOG41062JF Transcriptional regulator DN399_02300 ENOG4105DEU major facilitator superfamily DN399_02315 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DN399_02330 ENOG4108N0M stress protein DN399_02335 ENOG4106FN3 tellurium resistance protein DN399_02340 ENOG4106FN3 tellurium resistance protein DN399_02345 ENOG4107TS3 membrane protein, TerC DN399_02350 ENOG4108TTB tellurium resistance protein DN399_02365 ENOG41068PA UPF0435 protein DN399_02370 ENOG4105KJF protein tyrosine phosphatase DN399_02380 ENOG4107U9T Pfam:Ribonuclease_BN DN399_02385 ENOG4105C59 p-type ATPase DN399_02390 ENOG4108IPJ Membrane DN399_02410 ENOG4107ZTW SNARE associated Golgi DN399_02425 ENOG410606W general stress protein DN399_02430 ENOG4105UPD Calcium Proton DN399_02465 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DN399_02470 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN399_02480 ENOG4108JUB Transcriptional regulator DN399_02490 ENOG4108IQI permease DN399_02530 ENOG4108A04 Beta-lactamase DN399_02545 ENOG4105CKK Glycosyl transferase, family 2 DN399_02550 ENOG4107QQG Dehydrogenase DN399_02555 ENOG4105C3I Nad-dependent epimerase dehydratase DN399_02575 ENOG4105F1A Pyruvate formate-lyase DN399_02595 ENOG4105CI2 imidazolone-5-propionate hydrolase DN399_02600 ENOG4105ECP epimerase DN399_02630 ENOG41067AE Membrane-bound metal-dependent hydrolase DN399_02635 ENOG4105CEN a g-specific adenine glycosylase DN399_02640 ENOG4106BXE DN399_02660 ENOG4105BZ1 (ABC) transporter DN399_02665 ENOG4107NBY Membrane DN399_02670 ENOG4105CBC glutamate synthase DN399_02680 ENOG4108IUW ABC transporter DN399_02700 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN399_02705 ENOG4105G5W regulator Fur family DN399_02815 ENOG4105CDY transcriptional regulatory protein DN399_02825 ENOG4108JQC penicillin-binding protein 1A DN399_02830 ENOG4108R9S DSBA oxidoreductase DN399_02840 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DN399_02850 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DN399_02855 ENOG4105BZU Histidine kinase DN399_02860 ENOG4105CYN Serine protein kinase DN399_02880 ENOG4105C94 Transporter DN399_02895 ENOG4105DZ6 Band 7 protein DN399_02905 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DN399_02910 ENOG4108V9W transcriptional regulatory protein DN399_02915 ENOG4105D4T Citrate transporter DN399_02940 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN399_02945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN399_02950 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DN399_02955 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DN399_02960 ENOG4105BZ7 extracellular solute-binding protein family 1 DN399_02965 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DN399_02970 ENOG4108STX response regulator DN399_02975 ENOG41062D9 Histidine kinase DN399_03000 ENOG4108MRH transcriptional regulatory protein DN399_03010 ENOG4105C6K Malic enzyme DN399_03020 ENOG4108UZ3 Transporter DN399_03025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN399_03035 ENOG4105BZU Histidine kinase DN399_03045 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN399_03050 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN399_03055 ENOG4108JB9 formate dehydrogenase DN399_03075 ENOG4105CUB amino acid DN399_03090 ENOG4105C59 p-type ATPase DN399_03095 ENOG4105DAP Nicotinate phosphoribosyltransferase DN399_03125 ENOG41073R8 VanW family DN399_03130 ENOG4108KGH TRANSCRIPTIONal DN399_03135 ENOG4105D9N nucleoside DN399_03140 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DN399_03145 ENOG4105C37 (CBS) domain DN399_03150 ENOG4108IJ0 Aspartate ammonia-lyase DN399_03155 ENOG4105DAA L-lactate DN399_03170 ENOG4105DUX Transporter DN399_03175 ENOG4108MES Periplasmic binding protein DN399_03180 ENOG4105DQ5 transport system permease protein DN399_03185 ENOG4108IHU transport system permease protein DN399_03190 ENOG4105E0A ABC, transporter DN399_03195 ENOG4105DMQ Methyltransferase DN399_03200 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DN399_03205 ENOG4105EXW epimerase dehydratase DN399_03215 ENOG4107T89 von Willebrand factor, type A DN399_03220 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DN399_03225 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN399_03235 ENOG4105BZU Histidine kinase DN399_03240 ENOG4105D5Q Arginine ornithine antiporter DN399_03245 ENOG4107414 GntR family transcriptional regulator DN399_03250 ENOG4105C5Y PTS System DN399_03255 ENOG4105CG3 alpha amylase, catalytic region DN399_03270 ENOG4105E1K spore germination protein DN399_03275 ENOG4105CRN Aminoglycoside phosphotransferase DN399_03280 ENOG4105BZG amino acid carrier protein DN399_03290 ENOG4105CDA abc transporter atp-binding protein DN399_03295 ENOG4105CT1 (ABC) transporter DN399_03300 ENOG4105EAD ABC transporter DN399_03305 ENOG4105DRP amino acid AbC transporter DN399_03310 ENOG4108IQI permease DN399_03325 ENOG4105D29 Helix-turn-helix type 11 domain protein DN399_03330 ENOG4105NAE bifunctional deaminase-reductase domain protein DN399_03335 ENOG4105BZU Histidine kinase DN399_03360 ENOG4105CHH sulfate transporter DN399_03365 ENOG41068KF Universal stress protein DN399_03375 ENOG4105CXY transporter DN399_03380 ENOG41067TZ transcriptional regulator, MarR family DN399_03385 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN399_03390 ENOG4105ETE Transcriptional regulator (LacI family DN399_03395 ENOG4108RVA ribokinase DN399_03405 ENOG4105C2J ABC transporter DN399_03410 ENOG4105CNN ABC, transporter DN399_03415 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DN399_03420 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DN399_03455 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) DN399_03485 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN399_03490 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN399_03495 ENOG41069ER domain protein DN399_03500 ENOG4105VZ8 Transcriptional regulator DN399_03505 ENOG4107D63 DN399_03520 ENOG4105DUX Transporter DN399_03540 ENOG4105C85 amino acid DN399_03545 ENOG4105C7N Xanthine uracil vitamin C permease DN399_03560 ENOG4105MA6 gCN5-related N-acetyltransferase DN399_03580 ENOG4105CCU oxidase (Subunit III) DN399_03585 ENOG4105BZ9 Cytochrome C oxidase, subunit I DN399_03590 ENOG4105E2S oxidase) subunit II DN399_03610 ENOG4106CAD Protein of unknown function (DUF3311) DN399_03615 ENOG4105E1V na solute symporter DN399_03630 ENOG4108NHD germination protein DN399_03635 ENOG4105CE1 Ferrous iron transport protein b DN399_03640 ENOG4105CE1 Ferrous iron transport protein b DN399_03645 ENOG4105CE1 Ferrous iron transport protein b DN399_03650 ENOG4105CVA phosphate DN399_03655 ENOG4105C8U phosphate abc transporter DN399_03660 ENOG4105E2Z phosphate ABC transporter (Permease DN399_03790 ENOG41080XQ Signal transduction protein with cbs domains DN399_03810 ENOG4105ETU transcriptional activator (TenA DN399_03820 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN399_03830 ENOG4108VEU Thiamine monophosphate synthase DN399_03835 ENOG41080HI glycine oxidase DN399_03850 ENOG4105D06 uba thif-type nad fad binding protein DN399_03855 ENOG4105DWF phosphomethylpyrimidine kinase DN399_03905 ENOG4108INS Transcriptional regulator DN399_03915 ENOG4105C7N Xanthine uracil vitamin C permease DN399_03925 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN399_03945 ENOG4105C5Y PTS System DN399_03960 ENOG4105K63 Thioredoxin DN399_03980 ENOG4108B31 Spore germination protein DN399_04000 ENOG4107Y03 Nitroreductase DN399_04005 ENOG4105ED1 spovr family DN399_04015 ENOG4108TCS Glutamyl endopeptidase DN399_04040 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DN399_04045 ENOG4105XTG Pfam:DUF156 DN399_04050 ENOG4105VFE sira family DN399_04055 ENOG4107TPS domain protein DN399_04060 ENOG4105VFE sira family DN399_04065 ENOG4105VFE sira family DN399_04070 ENOG41085GJ domain protein DN399_04075 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DN399_04080 ENOG41087NI Sulfite exporter TauE/SafE DN399_04090 ENOG4108KGH TRANSCRIPTIONal DN399_04120 ENOG4105EMD TRANSCRIPTIONal DN399_04125 ENOG4105VCP PTS System DN399_04130 ENOG4105VZJ PTS System DN399_04155 ENOG41069ER domain protein DN399_04160 ENOG4107RBB ABC transporter, permease DN399_04165 ENOG4105C19 ABC transporter DN399_04195 ENOG4105WEF catalase DN399_04230 ENOG4107T5V SNARE associated Golgi DN399_04260 ENOG4105CUB amino acid DN399_04265 ENOG4107RWR Sodium hydrogen exchanger DN399_04275 ENOG4106KNT transcriptional regulator DN399_04315 ENOG4108YXU transcriptional regulator AsnC family DN399_04320 ENOG4105CH7 arginosuccinase DN399_04325 ENOG4108IXY short-chain dehydrogenase reductase DN399_04340 ENOG4105KPY Small multidrug resistance protein DN399_04375 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN399_04380 ENOG4105E5W Transporter DN399_04390 ENOG4105CH6 catalase DN399_04400 ENOG4105D5Q Arginine ornithine antiporter DN399_04415 ENOG4105C26 Dehydrogenase DN399_04430 ENOG4105BZ1 (ABC) transporter DN399_04435 ENOG4105BZ1 (ABC) transporter DN399_04450 ENOG4105DRP amino acid AbC transporter DN399_04455 ENOG4105CDA abc transporter atp-binding protein DN399_04470 ENOG410839P DN399_04480 ENOG4108UH6 UPF0754 membrane protein DN399_04505 ENOG4107FQX Alpha-acetolactate decarboxylase DN399_04530 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN399_04535 ENOG4105D4P Coproporphyrinogen iii oxidase DN399_04540 ENOG4105CEY Amp-dependent synthetase and ligase DN399_04555 ENOG4105CHH sulfate transporter DN399_04585 ENOG4105CGU Enoyl-CoA hydratase DN399_04605 ENOG4105DER m42 family DN399_04630 ENOG4105CIF Ornithine Cyclodeaminase DN399_04645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN399_04655 ENOG4108JQ7 (ABC) transporter DN399_04685 ENOG4105CSH Transporter DN399_04695 ENOG4108MRH transcriptional regulatory protein DN399_04750 ENOG4105CDU Replicative dna helicase DN399_04775 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN399_04790 ENOG4105D9U N-acetyltransferase DN399_04815 ENOG4105F6J Alpha beta hydrolase fold DN399_04855 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN399_04875 ENOG4105CMT Dihydroxyacetone kinase DN399_04890 ENOG4105CMT Dihydroxyacetone kinase DN399_04950 ENOG4108WC5 Alpha Beta Hydrolase Fold protein DN399_05010 ENOG4105WN5 stage II sporulation protein DN399_05020 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN399_05030 ENOG4108MJI response regulator DN399_05035 ENOG4105BZU Histidine kinase DN399_05040 ENOG4105BZU Histidine kinase DN399_05060 ENOG4105K8R UPF0145 protein DN399_05075 ENOG4107QHE Choloylglycine hydrolase DN399_05095 ENOG4107VRP DNA repair exonuclease DN399_05100 ENOG4106D4I domain protein DN399_05135 ENOG4108MUZ hydrolase DN399_05150 ENOG4105F0F Oxalate decarboxylase DN399_05155 ENOG41067QW Transcriptional regulator DN399_05160 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN399_05175 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DN399_05190 ENOG4105DU6 RNA polymerase DN399_05210 ENOG4105EYF MMPL domain protein DN399_05215 ENOG4105EEM helicase DN399_05225 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN399_05255 ENOG4105K59 histidine triad (HIT) protein DN399_05285 ENOG410905X membrane-flanked domain protein DN399_05290 ENOG4105CKV Membrane DN399_05335 ENOG410905X membrane-flanked domain protein DN399_05340 ENOG4105CKV Membrane DN399_05345 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DN399_05350 ENOG4105BZ4 penicillin-binding protein DN399_05360 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DN399_05365 ENOG4105C1Q protoporphyrinogen oxidase DN399_05395 ENOG4105ECB domain protein DN399_05425 ENOG4108MK9 spermidine N(1)-acetyltransferase DN399_05435 ENOG4106AXD DN399_05440 ENOG4108RQ5 Beta-lactamase domain-containing protein DN399_05445 ENOG4105DF9 Lipoate-protein, ligase DN399_05455 ENOG4105CEY Amp-dependent synthetase and ligase DN399_05465 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DN399_05470 ENOG4108I5D sulfate abc transporter DN399_05475 ENOG4105ECW sulfate abc transporter DN399_05480 ENOG4108IJ6 ABC transporter DN399_05545 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DN399_05555 ENOG4107RN3 metallophosphoesterase DN399_05560 ENOG4107TVP HD domain protein DN399_05570 ENOG4108AEY RNA polymerase sigma factor DN399_05575 ENOG41086D8 Transcriptional regulator DN399_05585 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN399_05605 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DN399_05610 ENOG4105C8Q Methyl-accepting chemotaxis DN399_05615 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) DN399_05625 ENOG4107QP3 malate synthase g DN399_05645 ENOG4105VEQ Cold shock protein DN399_05725 ENOG4105ERH Fumarylacetoacetate hydrolase DN399_05735 ENOG4105C8Y Acetylornithine aminotransferase DN399_05740 ENOG4106BKT UPF0344 protein DN399_05750 ENOG4105CAQ asparagine synthetase DN399_05755 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DN399_05760 ENOG4105CH6 catalase DN399_05765 ENOG4105BZU Histidine kinase DN399_05785 ENOG4108VPT UPF0234 protein DN399_05790 ENOG4105QNR S1 RNA binding domain protein DN399_05795 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN399_05805 ENOG4107AYK membrAne DN399_05810 ENOG41073B9 DN399_05820 ENOG4108KP7 hydrolase DN399_05830 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DN399_05855 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DN399_05860 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DN399_05880 ENOG4105C31 Tryptophanyl-tRNA synthetase DN399_05900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN399_05905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN399_05915 ENOG4108JQ7 (ABC) transporter DN399_05920 ENOG4105UQX Mate efflux family protein DN399_05940 ENOG4108ZCF integral membrane protein DN399_05950 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN399_05960 ENOG4105DPN Oligoendopeptidase f DN399_05970 ENOG4108Z18 K06886 hemoglobin DN399_05975 ENOG4105MIX Adenylate cyclase DN399_05980 ENOG4106EFP UPF0738 protein DN399_05990 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DN399_05995 ENOG4105EMS pseudouridine synthase DN399_06015 ENOG4105K64 Glycosyl transferase, family 2 DN399_06035 ENOG4107TVC Glycosyl transferase, family 2 DN399_06055 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DN399_06060 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DN399_06070 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DN399_06120 ENOG4108ZMI UPF0477 protein DN399_06150 ENOG4105CK7 Sodium proline symporter DN399_06160 ENOG4105CRQ synthase (Component I) DN399_06165 ENOG4105DDQ anthranilate synthase DN399_06175 ENOG4105DK0 Indole-3-glycerol phosphate synthase DN399_06190 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DN399_06255 ENOG4105C7S Dehydrogenase DN399_06260 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DN399_06265 ENOG4105VZ8 Transcriptional regulator DN399_06325 ENOG4105DZ1 carboxypeptidase DN399_06330 ENOG4105VFR signal peptidase DN399_06365 ENOG4105C26 Dehydrogenase DN399_06370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN399_06375 ENOG4105F38 ABC transporter, permease DN399_06380 ENOG4105D38 putrescine abc transporter DN399_06385 ENOG4107RUE extracellular solute-binding protein family 1 DN399_06395 ENOG4105EYF MMPL domain protein DN399_06405 ENOG4108YBP pseudouridine synthase DN399_06415 ENOG4105K4I Scp-like extracellular DN399_06420 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DN399_06425 ENOG4105CQB FAD linked oxidase domain protein DN399_06440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_06445 ENOG4105BZU Histidine kinase DN399_06450 ENOG4105JXH GntR family transcriptional regulator DN399_06470 ENOG4106A3R peptidase DN399_06480 ENOG4108QTI )-transporter DN399_06485 ENOG4107TS3 membrane protein, TerC DN399_06490 ENOG4105CZN Potassium uptake protein DN399_06495 ENOG410681C small acid-soluble spore protein DN399_06500 ENOG4108Z7G MaoC domain protein dehydratase DN399_06520 ENOG4105CHR reductase DN399_06550 ENOG4105C4Y ABC transporter DN399_06555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN399_06560 ENOG4107RCV ABC transporter, permease DN399_06580 ENOG4105E98 transcriptional regulator DeoR family DN399_06590 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DN399_06600 ENOG4105PXI polysaccharide deacetylase DN399_06610 ENOG4105BZU Histidine kinase DN399_06615 ENOG41090MY MarR family Transcriptional regulator DN399_06625 ENOG4106DF1 DN399_06630 ENOG4105BZU Histidine kinase DN399_06635 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DN399_06640 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DN399_06645 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DN399_06685 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DN399_06690 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DN399_06695 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DN399_06700 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN399_06705 ENOG4105CZV ABC transporter DN399_06715 ENOG4105CJ1 ABC, transporter DN399_06755 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DN399_06760 ENOG4105EA8 2-Nitropropane dioxygenase DN399_06765 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN399_06775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DN399_06795 ENOG4105NQC Flavodoxin DN399_06825 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN399_06855 ENOG4105CZN Potassium uptake protein DN399_06860 ENOG41063Y9 DN399_06865 ENOG4105KBJ sporulation protein ytfj DN399_06885 ENOG4105CM2 brancheD-chain amino acid aminotransferase DN399_06890 ENOG4105C7K acetolactate synthase DN399_06895 ENOG4108ZP8 Acetolactate synthase small subunit DN399_06900 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DN399_06915 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DN399_06935 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DN399_06940 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DN399_06965 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase DN399_06970 ENOG4107RVV histidinol phosphate phosphatase, hisj family DN399_06985 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN399_06990 ENOG4105E0M Sulfatase DN399_07000 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DN399_07015 ENOG4107S4M Sulfate adenylate transferase DN399_07020 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DN399_07025 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DN399_07035 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN399_07040 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN399_07045 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN399_07050 ENOG4105C8J )-transporter DN399_07070 ENOG4105DFD Na H antiporter DN399_07090 ENOG4105ENE Histidine kinase DN399_07095 ENOG4105WH1 Two component transcriptional regulator luxr family DN399_07115 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN399_07140 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DN399_07160 ENOG4105CJ3 phosphate transporter DN399_07165 ENOG4107GRR phosphate transport regulator DN399_07170 ENOG4105BZ4 penicillin-binding protein DN399_07185 ENOG4105BZU Histidine kinase DN399_07190 ENOG4105I3N Conserved Protein DN399_07205 ENOG4105BZU Histidine kinase DN399_07240 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN399_07245 ENOG4105DZ1 carboxypeptidase DN399_07250 ENOG4108JIC nucleoside recognition domain protein DN399_07260 ENOG4105FE9 pseudouridine synthase DN399_07265 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN399_07270 ENOG4107TWT Cytochrome c biogenesis protein DN399_07275 ENOG4105CRE cytochrome C DN399_07280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_07285 ENOG4105BZU Histidine kinase DN399_07290 ENOG4108WBT adenosyltransferase DN399_07305 ENOG4108SAX Membrane DN399_07320 ENOG4105C9U ATP-dependent DNA helicase RecQ DN399_07325 ENOG4105I7S Abortive infection protein DN399_07335 ENOG4107RGJ metallophosphoesterase DN399_07340 ENOG4108XDN Transcriptional regulator DN399_07345 ENOG4108S6Z Negative regulator of genetic competence DN399_07370 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DN399_07375 ENOG4107RB3 L-asparaginase DN399_07390 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DN399_07405 ENOG4105S2F DN399_07410 ENOG41065D1 DN399_07440 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DN399_07455 ENOG4105XXQ heptaprenyl diphosphate synthase component I DN399_07465 ENOG4105EAH synthase DN399_07470 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DN399_07475 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN399_07490 ENOG41068YB TPR repeat-containing protein DN399_07505 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DN399_07510 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DN399_07545 ENOG4108JYZ YitT family DN399_07555 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DN399_07570 ENOG4105FJR Lmbe family DN399_07575 ENOG4105CPK Glycosyl transferase (Group 1 DN399_07595 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DN399_07610 ENOG4105DVT helicase DN399_07615 ENOG4105YAC DN399_07635 ENOG4105CSM endonuclease III DN399_07645 ENOG4105BZ4 penicillin-binding protein DN399_07685 ENOG4106F55 Protein of unknown function (DUF1273) DN399_07700 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DN399_07710 ENOG4105DVT helicase DN399_07715 ENOG4105CTD carboxy-peptidase DN399_07725 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN399_07730 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DN399_07735 ENOG4105C2W permease DN399_07740 ENOG4105DHF Membrane DN399_07745 ENOG410890F Dynamin family DN399_07755 ENOG4108W0I acetyltransferase DN399_07765 ENOG4105KHC sulfurtransferase DN399_07790 ENOG4106032 Glutathionylspermidine synthase DN399_07825 ENOG4105HTX biosynthesis protein DN399_07855 ENOG4105CPK Glycosyl transferase (Group 1 DN399_07870 ENOG4108SZE gCN5-related N-acetyltransferase DN399_07890 ENOG41081VK Ribonuclease DN399_07955 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN399_07965 ENOG4107RWR Sodium hydrogen exchanger DN399_07970 ENOG4105CN5 Metallo-Beta-Lactamase DN399_07975 ENOG4108Z5V transcriptional regulator, merr family DN399_07985 ENOG4105H67 Protein of unknown function (DUF421) DN399_07990 ENOG41080C8 DUF218 domain DN399_08025 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DN399_08035 ENOG4107R0U MotA TolQ exbB proton channel DN399_08040 ENOG4105ER2 Ompa motb domain protein DN399_08045 ENOG4107YTP response regulator receiver protein DN399_08050 ENOG4105CBS Chea signal transduction histidine kinase DN399_08055 ENOG4105DD5 Flagellar motor switch protein DN399_08070 ENOG4105BZU Histidine kinase DN399_08090 ENOG4105E1Q flagellar hook-associated protein DN399_08095 ENOG4105DTJ flagellar hook-associated protein DN399_08115 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DN399_08120 ENOG4108ZC9 flagellar basal-body rod protein flgc DN399_08125 ENOG41075Z6 flagellar hook-basal body complex protein fliE DN399_08130 ENOG4107U2N Flagellar M-ring protein DN399_08135 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN399_08165 ENOG4105BZE flagellar hook protein, FlgE DN399_08180 ENOG4107R88 Chemotaxis protein (CheV) DN399_08190 ENOG4105I03 Flagellin DN399_08195 ENOG4105I03 Flagellin DN399_08200 ENOG4105E4C Lytic transglycosylase catalytic DN399_08210 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN399_08215 ENOG4105DD5 Flagellar motor switch protein DN399_08225 ENOG4105CN7 Flagellar biosynthetic protein FliP DN399_08230 ENOG4105VS8 Flagellar biosynthetic protein fliq DN399_08240 ENOG4105D00 flagellar biosynthetic protein flhB DN399_08245 ENOG4105D7B Flagellar biosynthesis protein flha DN399_08250 ENOG4105FZW flagellar biosynthesis regulator FlhF DN399_08255 ENOG4105KTQ flagellar basal-body rod protein DN399_08260 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN399_08295 ENOG4105KAC Antibiotic biosynthesis monooxygenase DN399_08320 ENOG4105DUM transcriptional regulator, lysR family DN399_08335 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DN399_08340 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DN399_08370 ENOG4105CVJ phosphoglycerate mutase DN399_08380 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DN399_08400 ENOG4105CAQ asparagine synthetase DN399_08420 ENOG4105PGM cation diffusion facilitator family transporter DN399_08430 ENOG4105DRR Transcriptional regulator, GntR family DN399_08435 ENOG4108UZ3 Transporter DN399_08445 ENOG4105CKI cobalamin synthesis protein DN399_08455 ENOG4108PJD permease DN399_08470 ENOG4105DFD Na H antiporter DN399_08475 ENOG4105VUF Transcriptional regulator DN399_08485 ENOG4105C9Q fumarate hydratase class II DN399_08500 ENOG4107QJQ Mate efflux family protein DN399_08505 ENOG4105EC3 peptidase S51, dipeptidase E DN399_08525 ENOG4107QIV Cytochrome c biogenesis protein DN399_08530 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN399_08550 ENOG4106BRA Membrane DN399_08580 ENOG4105WH1 Two component transcriptional regulator luxr family DN399_08590 ENOG4105CJ1 ABC, transporter DN399_08615 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DN399_08625 ENOG4108IJ0 Aspartate ammonia-lyase DN399_08630 ENOG4105C6K Malic enzyme DN399_08690 ENOG4105FVX DN399_08695 ENOG4105E09 nadh pyrophosphatase DN399_08710 ENOG4105CSR polyphosphate kinase 2 DN399_08715 ENOG4105U3E Transcriptional regulator DN399_08730 ENOG4105DXI Major Facilitator superfamily DN399_08740 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN399_08745 ENOG4105EU0 Major facilitator Superfamily DN399_08750 ENOG4105C6T cysteine synthase DN399_08770 ENOG4105C8J )-transporter DN399_08780 ENOG4105X5K response regulator receiver protein DN399_08785 ENOG4105H67 Protein of unknown function (DUF421) DN399_08800 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DN399_08805 ENOG4105CHR reductase DN399_08810 ENOG4105CM2 brancheD-chain amino acid aminotransferase DN399_08815 ENOG4105C7K acetolactate synthase DN399_08825 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DN399_08835 ENOG4105C7B Threonine dehydratase DN399_08860 ENOG4105C6X Major Facilitator DN399_08865 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DN399_08875 ENOG4105DY9 regulatoR DN399_08880 ENOG4105CYC Transferase DN399_08885 ENOG4105K5X acetyltransferase DN399_08905 ENOG41068WN DN399_08925 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DN399_08930 ENOG4105C72 UPF0176 protein DN399_08940 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DN399_08945 ENOG4105C0X amino acid DN399_08990 ENOG410849A acetyltransferase, (GNAT) family DN399_09015 ENOG4107RHR regulatoR DN399_09025 ENOG4105D9N nucleoside DN399_09030 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DN399_09085 ENOG410811B TRANSCRIPTIONal DN399_09100 ENOG4107RAQ aminopeptidase DN399_09110 ENOG4107R16 Multicopper oxidase DN399_09165 ENOG4108T5E Copper resistance protein DN399_09170 ENOG4105KTB nuclear export factor GLE1 DN399_09175 ENOG4107RT3 EamA-like transporter family DN399_09180 ENOG4105GZI Transcriptional regulator DN399_09185 ENOG4108Z40 Transcriptional regulator DN399_09190 ENOG4107ZXU DSBA oxidoreductase DN399_09195 ENOG4108TVJ Nitroreductase DN399_09200 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN399_09205 ENOG4106F5Q Membrane DN399_09210 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN399_09225 ENOG4105CKI cobalamin synthesis protein DN399_09235 ENOG4105C0Z ABC transporter DN399_09240 ENOG4108IV0 ABC, transporter DN399_09245 ENOG4105C32 Amino acid ABC transporter (Permease) DN399_09255 ENOG4105SKE transcriptional Regulator LysR family DN399_09265 ENOG4105MDS 4-oxalocrotonate tautomerase DN399_09280 ENOG4105C4M (Ubiquinol oxidase) subunit I DN399_09285 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN399_09290 ENOG4108JJ9 ABC, transporter DN399_09295 ENOG4108JJ8 (ABC) transporter DN399_09305 ENOG4105K64 Glycosyl transferase, family 2 DN399_09315 ENOG4108UT6 Transferase hexapeptide repeat containing protein DN399_09370 ENOG4105BZ1 (ABC) transporter DN399_09375 ENOG4105EFI regulatoR DN399_09380 ENOG4105BZU Histidine kinase DN399_09390 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DN399_09395 ENOG4108ZJ4 polysaccharide deacetylase DN399_09415 ENOG4105D6E homoserine dehydrogenase DN399_09425 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DN399_09440 ENOG4108KGH TRANSCRIPTIONal DN399_09450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN399_09455 ENOG4105BZU Histidine kinase DN399_09460 ENOG4107VMI polysaccharide deacetylase DN399_09470 ENOG4105KT7 mgtC SapB transporter DN399_09475 ENOG4105VRR gCN5-related N-acetyltransferase DN399_09485 ENOG4105DUU IucA IucC family protein DN399_09490 ENOG4105CEY Amp-dependent synthetase and ligase DN399_09505 ENOG4108WBH protein TIM barrel DN399_09510 ENOG4105YWU small acid-soluble spore protein DN399_09520 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DN399_09525 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN399_09575 ENOG4105KRN Transcriptional regulator, abrb family DN399_09595 ENOG4105KAF membrAne DN399_09620 ENOG4105C8Q Methyl-accepting chemotaxis DN399_09635 ENOG4108K88 Membrane DN399_09640 ENOG4108WPJ Ferritin-like domain DN399_09655 ENOG4105DEN Luciferase family DN399_09670 ENOG4105VMI -acetyltransferase DN399_09675 ENOG4107QM2 Aldo Keto reductase DN399_09685 ENOG4105CKI cobalamin synthesis protein DN399_09695 ENOG4105DSE periplasmic solute binding protein DN399_09700 ENOG4105K4T epimerase DN399_09710 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN399_09755 ENOG4107T5V SNARE associated Golgi DN399_09770 ENOG4108PJD permease DN399_09780 ENOG4108S4H thioesterase Superfamily protein DN399_09790 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN399_09810 ENOG4105SXS Protein of unknown function (DUF456) DN399_09815 ENOG4105C37 (CBS) domain DN399_09835 ENOG4108Z7R Chaperone CsaA DN399_09855 ENOG4108ZRV stage ii sporulation protein p DN399_09865 ENOG4108VXD carboxy-peptidase DN399_09875 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN399_09895 ENOG4108ZRV stage ii sporulation protein p DN399_09905 ENOG4108X4Q Hydrolase DN399_09920 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN399_09940 ENOG41087PP glycosyltransferase MGT family DN399_09945 ENOG4108JYZ YitT family DN399_09950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN399_09980 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN399_10000 ENOG4106PAW secretion accessory protein EsaA YueB DN399_10010 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) DN399_10015 ENOG4108MGT Required for secretion of EsxA and EsxB DN399_10070 ENOG4105KBJ sporulation protein ytfj DN399_10095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN399_10115 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DN399_10120 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DN399_10130 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DN399_10135 ENOG4105EMN RNA polymerase sigma factor DN399_10160 ENOG4108V06 Glutathione peroxidase DN399_10175 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN399_10185 ENOG4108IUE nitrate reductase beta subunit DN399_10190 ENOG4105R3A Nitrate reductase DN399_10200 ENOG4107V6Q Cyclic nucleotide-binding domain DN399_10205 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN399_10210 ENOG4105D06 uba thif-type nad fad binding protein DN399_10215 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN399_10220 ENOG4108ZAF Molybdopterin DN399_10255 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN399_10260 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN399_10265 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN399_10270 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DN399_10275 ENOG4108IFG nitrite reductase, (NAD(P)H) DN399_10280 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DN399_10315 ENOG4105MCT stage V sporulation protein S DN399_10360 ENOG4105C5H ABC transporter DN399_10375 ENOG4108UUM single-stranded DNA-binding protein DN399_10400 ENOG4107YX5 Pfam:DUF548 DN399_10405 ENOG4105C75 arginyL-tRNA synthetase DN399_10430 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN399_10460 ENOG4105C5S asparaginyl-tRNA synthetase DN399_10465 ENOG4105C8J )-transporter DN399_10485 ENOG4107XGZ Hydrolase DN399_10490 ENOG4105CY2 Citrate transporter DN399_10510 ENOG4105KD7 acetyltransferase DN399_10520 ENOG4105VMP Transcriptional regulator DN399_10525 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DN399_10550 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DN399_10565 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DN399_10570 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DN399_10580 ENOG4107RVG penicillin-binding protein DN399_10585 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DN399_10590 ENOG4105E9Q Acyl-transferase DN399_10595 ENOG4108UT2 hemolysin iii DN399_10605 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DN399_10615 ENOG4108RCR degv family DN399_10625 ENOG4108KF3 Electron transport protein SCO1 SenC DN399_10630 ENOG4107Y70 Heat shock protein DN399_10635 ENOG4105CAQ asparagine synthetase DN399_10650 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN399_10655 ENOG4108MES Periplasmic binding protein DN399_10660 ENOG4105F0I Aminotransferase DN399_10695 ENOG4105D8X mechanosensitive ion channel DN399_10700 ENOG4105BZU Histidine kinase DN399_10705 ENOG4105WH1 Two component transcriptional regulator luxr family DN399_10710 ENOG4106KNT transcriptional regulator DN399_10715 ENOG4107ZY0 Phenazine biosynthesis-like protein DN399_10735 ENOG4105CMG Carbohydrate kinase DN399_10740 ENOG4105C6Z Gluconate DN399_10750 ENOG4108YV3 Protein of unknown function (DUF2711) DN399_10780 ENOG4108IJ8 ABC transporter DN399_10785 ENOG4105E90 ABC transporter DN399_10820 ENOG4105C37 (CBS) domain DN399_10845 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN399_10860 ENOG4107S4Y M20 DapE family protein YgeY DN399_10865 ENOG4108TSC N-acetyltransferase DN399_10870 ENOG4108JUB Transcriptional regulator DN399_10875 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DN399_10920 ENOG410841Q phosphoesterase PA-phosphatase related protein DN399_10930 ENOG4105SZ6 Thioredoxin DN399_10975 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN399_11030 ENOG4105BZ4 penicillin-binding protein DN399_11040 ENOG4105CZM Major Facilitator DN399_11045 ENOG4105W8X HesB YadR YfhF-family protein DN399_11055 ENOG4105DXD 2-methylcitrate dehydratase DN399_11060 ENOG4105CR4 methylisocitrate lyase DN399_11065 ENOG4105C1G acyl-Coa dehydrogenase DN399_11070 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN399_11080 ENOG4105N14 lysine exporter protein LysE YggA DN399_11085 ENOG4105E39 Enoyl-CoA hydratase DN399_11100 ENOG4107RFY SbcCD D subunit DN399_11105 ENOG4105EYH Exonuclease DN399_11130 ENOG4105FCD Major Facilitator DN399_11135 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DN399_11140 ENOG4105E4F Isochorismate synthase DN399_11145 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DN399_11150 ENOG4105WQI isochorismatase DN399_11155 ENOG4105CEY Amp-dependent synthetase and ligase DN399_11160 ENOG4105WQT MbtH domain protein DN399_11165 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN399_11180 ENOG4105K70 DNA-binding protein DN399_11200 ENOG4105BZG amino acid carrier protein DN399_11220 ENOG4105FE9 pseudouridine synthase DN399_11225 ENOG4105C22 threonyL-tRNA synthetase DN399_11230 ENOG4105C19 ABC transporter DN399_11285 ENOG41081I9 integral membrane protein DN399_11295 ENOG4108Y4K DNA-binding transcriptional activator DN399_11305 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) DN399_11315 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DN399_11325 ENOG4105EYF MMPL domain protein DN399_11345 ENOG4105WCN acetyltransferase DN399_11365 ENOG4105C1Q protoporphyrinogen oxidase DN399_11375 ENOG41068WN DN399_11400 ENOG4108KP7 hydrolase DN399_11410 ENOG4107V2S Transcriptional regulator DN399_11415 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN399_11435 ENOG4105DND Transcriptional regulator DN399_11440 ENOG4108RPX mosc domain containing protein DN399_11455 ENOG4105BZ1 (ABC) transporter DN399_11460 ENOG4105BZ1 (ABC) transporter DN399_11490 ENOG4108JCI Transcriptional regulator DN399_11525 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DN399_11530 ENOG4108KPJ rna polymerase sigma factor DN399_11550 ENOG4105F32 YngK protein DN399_11570 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DN399_11575 ENOG4105RD7 BadF BadG BcrA BcrD DN399_11580 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DN399_11590 ENOG4105C7B Threonine dehydratase DN399_11595 ENOG4108INS Transcriptional regulator DN399_11610 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DN399_11620 ENOG4105C1J atp-dependent rna helicase DN399_11710 ENOG4105XSJ toxin secretion phage lysis holin DN399_11715 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DN399_11730 ENOG41088CC tellurite resistance protein tehB DN399_11745 ENOG4107RA9 decarboxylase DN399_11750 ENOG41090HR transcriptional regulator DN399_11755 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DN399_11775 ENOG4105CIN aminoacyl-histidine dipeptidase DN399_11800 ENOG4105KRN Transcriptional regulator, abrb family DN399_11810 ENOG4105EJ9 Membrane DN399_11815 ENOG4105EQK -acetyltransferase DN399_11965 ENOG4105EJQ L-serine dehydratase DN399_11970 ENOG4105C44 Serine transporter DN399_11980 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN399_12005 ENOG4108IG5 Transcriptional regulator DN399_12015 ENOG4105FQP Beta-lactamase DN399_12020 ENOG4107RVG penicillin-binding protein DN399_12035 ENOG4107RF6 penicillin-binding protein DN399_12040 ENOG4107RF6 penicillin-binding protein DN399_12050 ENOG4105DIN metallophosphoesterase DN399_12060 ENOG4105CJ1 ABC, transporter DN399_12070 ENOG4107Z3H Transcriptional regulator, TetR family DN399_12085 ENOG4105C1G acyl-Coa dehydrogenase DN399_12090 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN399_12095 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DN399_12100 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DN399_12105 ENOG4105E39 Enoyl-CoA hydratase DN399_12110 ENOG4107QX3 carboxylase DN399_12115 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN399_12145 ENOG4105DBI uridine monophosphokinase DN399_12170 ENOG4105DZ1 carboxypeptidase DN399_12185 ENOG4105T9C HD domain DN399_12195 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DN399_12215 ENOG41075H3 AraC family transcriptional regulator DN399_12245 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DN399_12255 ENOG4107Y80 Major Facilitator superfamily DN399_12260 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DN399_12270 ENOG4105KVH Transcriptional regulator DN399_12275 ENOG41089UC methyltransferase, type 11 DN399_12325 ENOG4105EFA 4-hydroxyphenylacetate DN399_12340 ENOG4105CPQ Dehydrogenase DN399_12350 ENOG410900G Protein of unknown function (DUF421) DN399_12365 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DN399_12440 ENOG4105D6E homoserine dehydrogenase DN399_12450 ENOG4105CPF Cell wall formation (By similarity) DN399_12455 ENOG4105ETU transcriptional activator (TenA DN399_12485 ENOG4105VTR Integrase DN399_12565 ENOG4105KNA -acetyltransferase DN399_12660 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN399_12740 ENOG4105XSJ toxin secretion phage lysis holin DN399_12835 ENOG410667J hydrolase DN399_12840 ENOG4105BZU Histidine kinase DN399_12845 ENOG4107RF6 penicillin-binding protein DN399_12870 ENOG4108JJB ABC transporter DN399_12885 ENOG4108HGU Histidine kinase DN399_13010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_13015 ENOG4105GR3 Histidine kinase DN399_13020 ENOG4105CB2 alcohol dehydrogenase DN399_13025 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DN399_13030 ENOG4105CJN penicillin-binding protein DN399_13070 ENOG4108V4B ThiJ pfpI DN399_13085 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DN399_13110 ENOG4107Y9U Membrane DN399_13150 ENOG4105FCD Major Facilitator DN399_13160 ENOG4105E09 nadh pyrophosphatase DN399_13165 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN399_13185 ENOG4108XI2 Domain of unknown function (DUF1963) DN399_13210 ENOG4108NRW Phospholipase, patatin family DN399_13215 ENOG4105KWG Pfam:DUF1696 DN399_13225 ENOG4108YYS metal-dependent hydrolase (By similarity) DN399_13240 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN399_13250 ENOG4105PKS Excinuclease abc c subunit domain protein DN399_13290 ENOG4107VFR oxidoreductase DN399_13325 ENOG4105PAD Hydrolase DN399_13330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_13335 ENOG4105BZU Histidine kinase DN399_13355 ENOG4107WD8 ABC transporter, permease DN399_13370 ENOG4105DY8 decarboxylase DN399_13385 ENOG4108IUM Glycogen debranching enzyme DN399_13395 ENOG4105CGH 5'-nucleotidase DN399_13415 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN399_13420 ENOG4105FDR Membrane DN399_13425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN399_13430 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DN399_13475 ENOG4105MSI germination protein ypeb DN399_13505 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DN399_13510 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DN399_13515 ENOG4107Z3H Transcriptional regulator, TetR family DN399_13540 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DN399_13555 ENOG4105E98 transcriptional regulator DeoR family DN399_13570 ENOG41062ES Transcriptional regulator DN399_13590 ENOG4107QKR Dehydrogenase DN399_13600 ENOG4107RUY (E1 component), alpha subunit DN399_13610 ENOG4105E1F short-chain dehydrogenase reductase DN399_13640 ENOG4107SQ8 Glycine betaine DN399_13645 ENOG4108IJ7 Glycine betaine DN399_13655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN399_13670 ENOG4105E66 phosphoriboisomerase A DN399_13675 ENOG41082BV acetyltransferase DN399_13680 ENOG4108M1A Chitin-binding protein DN399_13710 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN399_13715 ENOG4105MSB protein, conserved in bacteria DN399_13740 ENOG4108Z7F N-acetyltransferase DN399_13760 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DN399_13765 ENOG4105EEM helicase DN399_13780 ENOG4105C9U ATP-dependent DNA helicase RecQ DN399_13835 ENOG4108M1A Chitin-binding protein DN399_13850 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DN399_13860 ENOG4105BZG amino acid carrier protein DN399_13865 ENOG4105C26 Dehydrogenase DN399_13870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN399_13875 ENOG4105CTU Proline racemase DN399_13880 ENOG4105CTU Proline racemase DN399_13885 ENOG41080HI glycine oxidase DN399_13895 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DN399_13925 ENOG4107T5V SNARE associated Golgi DN399_13935 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN399_13955 ENOG4105DTQ mandelate racemase muconate lactonizing DN399_13970 ENOG4107SET aldo keto reductase DN399_14005 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DN399_14010 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN399_14015 ENOG4105BZU Histidine kinase DN399_14020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_14040 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 DN399_14055 ENOG4105DPN Oligoendopeptidase f DN399_14060 ENOG4105EPR degv family DN399_14120 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN399_14125 ENOG4106K7D Major facilitator family transporter DN399_14145 ENOG4107BMA Transglycosylase associated protein DN399_14160 ENOG41089UC methyltransferase, type 11 DN399_14195 ENOG4105CHM Aminotransferase DN399_14210 ENOG4108ZMI UPF0477 protein DN399_14250 ENOG4105C02 permease DN399_14260 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DN399_14265 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DN399_14270 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DN399_14275 ENOG4105D7T ABC transporter DN399_14310 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DN399_14360 ENOG4107VC0 DNA alkylation repair enzyme DN399_14365 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DN399_14375 ENOG4107VMI polysaccharide deacetylase DN399_14385 ENOG4108ZCF integral membrane protein DN399_14390 ENOG4105E0M Sulfatase DN399_14395 ENOG4105C5H ABC transporter DN399_14400 ENOG4105EYF MMPL domain protein DN399_14405 ENOG41082JN Transcriptional regulator DN399_14425 ENOG4105CIH Imidazole acetol-phosphate transaminase DN399_14430 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN399_14435 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN399_14485 ENOG41069ER domain protein DN399_14495 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DN399_14500 ENOG4105DNP FAD linked oxidase domain protein DN399_14525 ENOG4105D4B ABC, transporter DN399_14530 ENOG4105F5R ABC transporter DN399_14535 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DN399_14545 ENOG4105DKT Transcriptional regulator DN399_14550 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DN399_14560 ENOG41061GT Aldolase DN399_14570 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DN399_14605 ENOG4105II7 pyrroline-5-carboxylate reductase DN399_14615 ENOG4107258 Transcriptional regulator DN399_14635 ENOG4105ECK Fatty Acid Desaturase DN399_14645 ENOG4107RBI VanW family DN399_14650 ENOG4105G6Z alkaline phosphatase DN399_14660 ENOG4105VMP Transcriptional regulator DN399_14675 ENOG41090T1 Membrane DN399_14685 ENOG4108WCX response regulator DN399_14695 ENOG41068WN DN399_14730 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN399_14755 ENOG4105CKK Glycosyl transferase, family 2 DN399_14785 ENOG4105C8Y Acetylornithine aminotransferase DN399_14830 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN399_14855 ENOG4108IBT Inherit from COG: transposase DN399_14875 ENOG4108TVJ Nitroreductase DN399_14880 ENOG4105FS7 Transcriptional regulator DN399_14905 ENOG4105WEC Molybdate metabolism regulator DN399_14925 ENOG4108DMH HTH_ARAC DN399_14930 ENOG4108XET gCN5-related N-acetyltransferase DN399_14945 ENOG4108PCN EamA-like transporter family DN399_14955 ENOG4107XJU UPF0178 protein DN399_14990 ENOG410635A Membrane DN399_15000 ENOG4108IQI permease DN399_15010 ENOG4105F1N DNA alkylation repair DN399_15070 ENOG4107RF6 penicillin-binding protein DN399_15075 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DN399_15095 ENOG4105E7W lamb ycsf family protein DN399_15105 ENOG4105P4J Allophanate hydrolase, subunit 1 DN399_15110 ENOG4107258 Transcriptional regulator DN399_15120 ENOG4106N3A copper homeostasis protein cutc DN399_15125 ENOG4108ZHR arsR family transcriptional regulator DN399_15135 ENOG4105FDT acyl-CoA dehydrogenase DN399_15150 ENOG4105DWD nucleoside recognition domain protein DN399_15195 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DN399_15220 ENOG4105E2A Dehydrogenase DN399_15225 ENOG4108IJ0 Aspartate ammonia-lyase DN399_15230 ENOG4105HDK L-asparaginase DN399_15235 ENOG4108IMY Transcriptional regulator DN399_15260 ENOG4108B31 Spore germination protein DN399_15270 ENOG4105BZU Histidine kinase DN399_15295 ENOG41075H3 AraC family transcriptional regulator DN399_15320 ENOG4105CUB amino acid DN399_15325 ENOG4105II7 pyrroline-5-carboxylate reductase DN399_15330 ENOG4108NHD germination protein DN399_15335 ENOG4108Q8B Spore germination protein DN399_15355 ENOG4105CSV Glutaminase DN399_15390 ENOG4105CGH 5'-nucleotidase DN399_15400 ENOG4105CHJ isochorismatase hydrolase DN399_15425 ENOG41090MY MarR family Transcriptional regulator DN399_15450 ENOG4105F6J Alpha beta hydrolase fold DN399_15465 ENOG4108606 TspO/MBR family DN399_15470 ENOG4105CVP deoxyribo-dipyrimidine photolyase DN399_15495 ENOG4108TWJ NADH dehydrogenase subunit 5 DN399_15500 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DN399_15505 ENOG4107VMI polysaccharide deacetylase DN399_15510 ENOG4105KY5 gCN5-related N-acetyltransferase DN399_15515 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN399_15530 ENOG4105NAE bifunctional deaminase-reductase domain protein DN399_15555 ENOG4107P5I polyketide synthase DN399_15560 ENOG4108IG5 Transcriptional regulator DN399_15565 ENOG4105F27 Major Facilitator DN399_15570 ENOG4105M4P Tetr family transcriptional regulator DN399_15575 ENOG4105CHR reductase DN399_15580 ENOG4108YXU transcriptional regulator AsnC family DN399_15610 ENOG4105N0V mono-oxygenase ydhR DN399_15645 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DN399_15650 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN399_15665 ENOG4105K6H D-cysteine desulfhydrase DN399_15675 ENOG4105E0Y RtcB Protein DN399_15685 ENOG4105JQZ Methyltransferase DN399_15705 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DN399_15725 ENOG4105BZU Histidine kinase DN399_15735 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN399_15745 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DN399_15770 ENOG4108JQ1 Dehydrogenase DN399_15775 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DN399_15815 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN399_15920 ENOG4108VXD carboxy-peptidase DN399_15925 ENOG4105PNM synthesis protein DN399_15935 ENOG4108ISG Major Facilitator DN399_15950 ENOG4107MII Sugar-specific transcriptional regulator TrmB DN399_15955 ENOG4105CZM Major Facilitator DN399_15965 ENOG4105CRW Short chain fatty acid transporter DN399_15975 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN399_16035 ENOG4108K8S endonuclease I DN399_16060 ENOG4108Z66 YbaK ebsC protein DN399_16065 ENOG4105CUT histidyl-tRNA synthetase DN399_16080 ENOG4105KVH Transcriptional regulator DN399_16085 ENOG4108RCM Nitroreductase DN399_16115 ENOG4108PSK reductase DN399_16190 ENOG4105C31 Tryptophanyl-tRNA synthetase DN399_16225 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) DN399_16265 ENOG4105C37 (CBS) domain DN399_16280 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DN399_16285 ENOG4105FAW cDP-glucose 4,6-dehydratase DN399_16320 ENOG4105DDN Pentapeptide repeat-containing protein DN399_16325 ENOG4105XDF Protein of unknown function (DUF1272) DN399_16330 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DN399_16335 ENOG4105CMG Carbohydrate kinase DN399_16340 ENOG4105C6Z Gluconate DN399_16345 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DN399_16360 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DN399_16365 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DN399_16375 ENOG4105CIS alcohol dehydrogenase DN399_16380 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DN399_16390 ENOG4105PDP Short chain dehydrogenase DN399_16400 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DN399_16415 ENOG4105C8Q Methyl-accepting chemotaxis DN399_16420 ENOG4108UX3 '-nucleotidase DN399_16425 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DN399_16430 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DN399_16435 ENOG4105KVH Transcriptional regulator DN399_16450 ENOG4105CV8 reductase DN399_16455 ENOG4105F27 Major Facilitator DN399_16465 ENOG41090KN UPF0303 protein DN399_16480 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DN399_16485 ENOG4105CHH sulfate transporter DN399_16500 ENOG4105C44 Serine transporter DN399_16535 ENOG4105KVH Transcriptional regulator DN399_16540 ENOG4108TZY GntR Family Transcriptional Regulator DN399_16545 ENOG4105D9R oxidoreductase DN399_16550 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DN399_16555 ENOG4105KVH Transcriptional regulator DN399_16560 ENOG4105KVH Transcriptional regulator DN399_16605 ENOG4105JAB phenazine biosynthesis protein, phzf family DN399_16615 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DN399_16620 ENOG4105KVH Transcriptional regulator DN399_16630 ENOG4108ZJ4 polysaccharide deacetylase DN399_16655 ENOG4105W1N transcriptional regulator DN399_16660 ENOG4105CVK Glutamate decarboxylase DN399_16730 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DN399_16760 ENOG4105H3G oxidoreductase DN399_16840 ENOG4108TN2 lmbE family DN399_16850 ENOG4107R3E Citrate transporter DN399_16860 ENOG4105WCN acetyltransferase DN399_16865 ENOG4108MES Periplasmic binding protein DN399_16870 ENOG4105EHG Permease protein DN399_16875 ENOG4105DQ5 transport system permease protein DN399_16880 ENOG4105NX3 Membrane DN399_16900 ENOG41068WN DN399_16905 ENOG4107CUJ Protein of unknown function (DUF2690) DN399_16915 ENOG4107V2S Transcriptional regulator DN399_16935 ENOG4105C98 muts2 protein DN399_16940 ENOG4105E5K Alpha-amylase DN399_16945 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DN399_16950 ENOG4105DPN Oligoendopeptidase f DN399_16975 ENOG4105FFC UPF0187 protein DN399_16995 ENOG4108A04 Beta-lactamase DN399_17020 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DN399_17030 ENOG41082BM Transcriptional regulator, arsr family DN399_17035 ENOG4105CB2 alcohol dehydrogenase DN399_17040 ENOG4105CNG UPF0061 protein DN399_17060 ENOG4105CQB FAD linked oxidase domain protein DN399_17085 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN399_17095 ENOG4107TPS domain protein DN399_17100 ENOG4105CEP NADH dehydrogenase DN399_17110 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DN399_17120 ENOG4108IAJ Nad-dependent epimerase dehydratase DN399_17125 ENOG4105FAW cDP-glucose 4,6-dehydratase DN399_17130 ENOG4105D7V transposase DN399_17165 ENOG41067SE Tetr family transcriptional regulator DN399_17170 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity DN399_17180 ENOG4107DUR UPF0457 protein DN399_17200 ENOG4105BZU Histidine kinase DN399_17210 ENOG4105KT7 mgtC SapB transporter DN399_17220 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN399_17225 ENOG41073R8 VanW family DN399_17235 ENOG4108R1P DN399_17250 ENOG4105VEQ Cold shock protein DN399_17270 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DN399_17290 ENOG410904N short-chain dehydrogenase reductase DN399_17300 ENOG4106IQC argininosuccinate lyase DN399_17315 ENOG4108IA2 Sodium pantothenate symporter DN399_17325 ENOG4105C26 Dehydrogenase DN399_17330 ENOG4105CHR reductase DN399_17340 ENOG4105EWU Squalene--hopene cyclase DN399_17350 ENOG4105FR1 rard protein DN399_17355 ENOG410696E Membrane DN399_17370 ENOG4105D1F ATP-binding protein DN399_17380 ENOG4108ZAF Molybdopterin DN399_17385 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN399_17390 ENOG4105D06 uba thif-type nad fad binding protein DN399_17395 ENOG4105TMB Formate nitrite transporter DN399_17405 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN399_17410 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DN399_17420 ENOG4108JB9 formate dehydrogenase DN399_17425 ENOG4105E1K spore germination protein DN399_17440 ENOG4105CUB amino acid DN399_17495 ENOG4107QJT sodium dicarboxylate symporter DN399_17500 ENOG4108KGH TRANSCRIPTIONal DN399_17510 ENOG4105EMN RNA polymerase sigma factor DN399_17520 ENOG4105CIG ABC transporter DN399_17530 ENOG4105D9R oxidoreductase DN399_17540 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN399_17545 ENOG4105K4P CoA-binding domain protein DN399_17550 ENOG4105C0H protease DN399_17555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_17565 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DN399_17570 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DN399_17575 ENOG4105W8X HesB YadR YfhF-family protein DN399_17605 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN399_17610 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN399_17620 ENOG4108JJA ABC, transporter DN399_17625 ENOG4108I0Z Aconitate hydratase DN399_17655 ENOG4105E5W Transporter DN399_17665 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN399_17685 ENOG4107F3J Amp-dependent synthetase and ligase DN399_17690 ENOG4107ZYJ bioY protein DN399_17695 ENOG4105CEY Amp-dependent synthetase and ligase DN399_17725 ENOG4105D9G High-affinity DN399_17730 ENOG4105IW1 AmiS UreI transporter DN399_17745 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DN399_17785 ENOG4107AYK membrAne DN399_17800 ENOG4105BZU Histidine kinase DN399_17805 ENOG4105FBA Phospholipase Carboxylesterase DN399_17810 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DN399_17815 ENOG4105CK7 Sodium proline symporter DN399_17825 ENOG4105CBC glutamate synthase DN399_17830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DN399_17835 ENOG4108VJ1 Transcriptional regulator (CarD family DN399_17840 ENOG4108903 Formimidoylglutamase DN399_17900 ENOG4107QIV Cytochrome c biogenesis protein DN399_17915 ENOG4105CH2 amidohydrolase DN399_17925 ENOG4105CJ1 ABC, transporter DN399_17940 ENOG4107RSM transcriptional regulator DN399_17945 ENOG4105VAW lrga family DN399_17950 ENOG41067MG lrgb family DN399_17990 ENOG4105BZ1 (ABC) transporter DN399_17995 ENOG4105BZ1 (ABC) transporter DN399_18030 ENOG4108HW3 (ABC) transporter DN399_18035 ENOG4105CGH 5'-nucleotidase DN399_18045 ENOG4108SVB resolvase DN399_18065 ENOG4105K7K Transcriptional regulator DN399_18075 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DN399_18080 ENOG4105DR5 peptidase DN399_18085 ENOG41065S2 pneumococcal vaccine antigen DN399_18115 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DN399_18120 ENOG4105C5F glutamine synthetase DN399_18125 ENOG4105KV4 Transcriptional regulator DN399_18130 ENOG4105CXI aluminum resistance protein DN399_18135 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN399_18140 ENOG4105EN6 Membrane DN399_18145 ENOG4106F1P AAA ATPase, central domain protein DN399_18175 ENOG41069ER domain protein DN399_18180 ENOG4105DM4 PTS System DN399_18185 ENOG4105DE4 1-phosphofructokinase DN399_18190 ENOG4105E98 transcriptional regulator DeoR family DN399_18195 ENOG4107QW4 alcohol dehydrogenase DN399_18200 ENOG4108SJC Membrane DN399_18210 ENOG4105C85 amino acid DN399_18230 ENOG4105TMB Formate nitrite transporter DN399_18235 ENOG4105K70 DNA-binding protein DN399_18245 ENOG4105C59 p-type ATPase DN399_18250 ENOG410681U heavy metal transport detoxification protein DN399_18255 ENOG4105VPX protein, conserved in bacteria DN399_18265 ENOG4105NIV Esterase DN399_18270 ENOG4105E0A ABC, transporter DN399_18305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN399_18310 ENOG4105D03 DNA-3-methyladenine glycosylase II DN399_18340 ENOG4105BZU Histidine kinase DN399_18380 ENOG41067MG lrgb family DN399_18400 ENOG4107YEI lmbE family DN399_18420 ENOG4105F0V Cell wall hydrolase DN399_18435 ENOG4105E0M Sulfatase DN399_18440 ENOG410890F Dynamin family DN399_18475 ENOG4105DQU oxidoreductase, subunit beta DN399_18480 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DN399_18485 ENOG4108IGT Dipeptidase DN399_18490 ENOG4105MCT stage V sporulation protein S DN399_18495 ENOG4105D48 metallophosphoesterase DN399_18515 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DN399_18530 ENOG4105XZV Protein of unknown function (DUF3243) DN399_18535 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DN399_18555 ENOG4105UIB (ABC) transporter DN399_18560 ENOG4108JQ9 ABC transporter DN399_18565 ENOG4105DIH basic membrane DN399_18570 ENOG4105FDP GntR family transcriptional regulator DN399_18580 ENOG4105CNU cell division protein FtsK DN399_18590 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DN399_18600 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN399_18610 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN399_18615 ENOG4108S0H Dipicolinic acid synthetase, b subunit DN399_18620 ENOG4105E35 Dipicolinate synthase subunit A DN399_18630 ENOG4105C1V Peptidase, M16 DN399_18650 ENOG4105DTN riboflavin biosynthesis protein ribF DN399_18665 ENOG4105W7A Protein of unknown function (DUF503) DN399_18675 ENOG4105VHM ribosomal protein DN399_18680 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DN399_18685 ENOG4105CHV Transcription elongation factor NusA DN399_18695 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN399_18705 ENOG4105DZP Membrane-associated zinc metalloprotease DN399_18710 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DN399_18715 ENOG4105KNE Phosphatidate cytidylyltransferase DN399_18720 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DN399_18730 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DN399_18760 ENOG4108HE4 integrase family DN399_18770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DN399_18775 ENOG4105C79 DNA protecting protein DprA DN399_18780 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DN399_18795 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DN399_18820 ENOG4105VB6 UPF0109 protein DN399_18840 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DN399_18845 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DN399_18860 ENOG4105CHR reductase DN399_18865 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DN399_18880 ENOG4105CB5 ATP-dependent DNA helicase recG DN399_18885 ENOG4105DP4 dak2 domain fusion protein ylov DN399_18890 ENOG4108ZAA Alkaline-shock protein DN399_18905 ENOG4105FJ0 thiamine DN399_18910 ENOG4105DJV ribulose-phosphate 3-epimerase DN399_18915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DN399_18920 ENOG4105D9P serine threonine protein kinase DN399_18925 ENOG4108ZF3 Phosphatase DN399_18935 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DN399_18950 ENOG4105C25 Primosomal protein n' DN399_18955 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DN399_18975 ENOG4105DSJ YicC domain protein DN399_18985 ENOG4105F23 Fibronectin-binding protein DN399_18990 ENOG4105DC7 peptidase M24 DN399_19015 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DN399_19030 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DN399_19035 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DN399_19045 ENOG4105CD3 dihydroorotase DN399_19065 ENOG4105C34 Pseudouridine synthase DN399_19080 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN399_19090 ENOG4105DBK s4 domain protein DN399_19095 ENOG41067XK integral membrane protein DN399_19105 ENOG4105DFA alanine racemase domain protein DN399_19110 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DN399_19115 ENOG4105WR5 sporulation protein, YlmC YmxH family DN399_19125 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN399_19135 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DN399_19140 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DN399_19150 ENOG4105D4A Cell wall formation (By similarity) DN399_19155 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN399_19160 ENOG4105CNI cell division protein FtsW DN399_19175 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DN399_19180 ENOG4105CJN penicillin-binding protein DN399_19185 ENOG4105CJN penicillin-binding protein DN399_19200 ENOG41074B2 UPF0747 protein DN399_19225 ENOG4105KNH Nucleic acid-binding protein DN399_19235 ENOG41063PX domain protein DN399_19240 ENOG4105D78 K07001 NTE family protein DN399_19245 ENOG4105H20 Sporulation integral membrane protein YlbJ DN399_19255 ENOG4106H78 methyltransferase DN399_19275 ENOG4107TB6 phosphoglycerate mutase DN399_19290 ENOG4106UY4 Inherit from COG: Scp-like extracellular DN399_19340 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DN399_19350 ENOG4105CNI cell division protein FtsW DN399_19365 ENOG4108IAB Phoh family DN399_19385 ENOG4105QA2 DN399_19390 ENOG4105CI3 gtp-binding protein typa DN399_19400 ENOG4105ECY inositol monophosphatase DN399_19420 ENOG4105CXN decarboxylase DN399_19470 ENOG4105CPP Dehydrogenase, E1 component DN399_19485 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DN399_19490 ENOG4108X4Q Hydrolase DN399_19505 ENOG4105CN5 Metallo-Beta-Lactamase DN399_19510 ENOG4107ZYR domain protein DN399_19545 ENOG4108XRC Protein of unknown function (DUF458) DN399_19550 ENOG4107IN1 Protein of unknown function (DUF1797) DN399_19565 ENOG4105EPM Diguanylate phosphodiesterase DN399_19570 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DN399_19585 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DN399_19595 ENOG4105UIN DN399_19630 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DN399_19650 ENOG4108HGU Histidine kinase DN399_19660 ENOG4105CHM Aminotransferase DN399_19665 ENOG4105FKQ transcriptional regulator DN399_19670 ENOG4105EG2 ABC transporter, permease DN399_19680 ENOG4107FKK extracellular solute-binding protein family 1 DN399_19690 ENOG4105CG3 alpha amylase, catalytic region DN399_19735 ENOG4105CHU acetyl-coa acetyltransferase DN399_19770 ENOG4105K7K Transcriptional regulator DN399_19775 ENOG4105DTD Dehydrogenase DN399_19795 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DN399_19820 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DN399_19835 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN399_19845 ENOG4105BZU Histidine kinase DN399_19865 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DN399_19880 ENOG4105CID antiterminator DN399_19890 ENOG4105FDP GntR family transcriptional regulator DN399_19900 ENOG4105CE4 GlcNAc 6-P deacetylase DN399_19940 ENOG4107ZE5 PPIases accelerate the folding of proteins DN399_19945 ENOG4105PTM secreted protein DN399_19950 ENOG4105J7I hydrolase DN399_19960 ENOG4105G6R Stage v sporulation protein ae DN399_19970 ENOG4105CZ3 stage V sporulation protein ad DN399_19975 ENOG41090VF Stage v sporulation protein ac DN399_19995 ENOG4105C8J )-transporter DN399_20000 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN399_20010 ENOG41082AN stage II sporulation protein DN399_20015 ENOG4105DZ1 carboxypeptidase DN399_20025 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN399_20030 ENOG4105DVE abc transporter atp-binding protein DN399_20065 ENOG4105D7N magnesium and cobalt transport protein CorA DN399_20090 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DN399_20100 ENOG4105I3K Ferric uptake regulator, Fur family DN399_20105 ENOG4105MZ9 stage II sporulation protein m DN399_20125 ENOG4105CPC Aldo Keto reductase DN399_20135 ENOG4105RHY Pfam:UPF0157 DN399_20155 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DN399_20165 ENOG4105ETE Transcriptional regulator (LacI family DN399_20170 ENOG4108YM7 Gcn5-related n-acetyltransferase DN399_20190 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DN399_20195 ENOG4108R6K riboflavin synthase, subunit alpha DN399_20220 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN399_20225 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN399_20240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN399_20250 ENOG4105DFD Na H antiporter DN399_20255 ENOG4105CGH 5'-nucleotidase DN399_20280 ENOG4105DBV ornithine carbamoyltransferase DN399_20295 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DN399_20310 ENOG4108IXY short-chain dehydrogenase reductase DN399_20315 ENOG41069FQ Metallo-beta-lactamase superfamily DN399_20320 ENOG4105II7 pyrroline-5-carboxylate reductase DN399_20325 ENOG4105EJQ L-serine dehydratase DN399_20340 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DN399_20355 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DN399_20370 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DN399_20375 ENOG4105D9U N-acetyltransferase DN399_20385 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DN399_20390 ENOG4108QEG Membrane DN399_20395 ENOG4105CDA abc transporter atp-binding protein DN399_20400 ENOG4105E5Q amino acid AbC transporter DN399_20405 ENOG4108HW3 (ABC) transporter DN399_20415 ENOG4105G7B Protein of unknown function (DUF2992) DN399_20425 ENOG4108QY0 Membrane DN399_20435 ENOG4105C7S Dehydrogenase DN399_20440 ENOG4105CPP Dehydrogenase, E1 component DN399_20455 ENOG4105CKM Branched-chain carboxylic acid kinase DN399_20460 ENOG4107RDP Dehydrogenase DN399_20475 ENOG4108JUB Transcriptional regulator DN399_20485 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN399_20500 ENOG4107QQR Sporulation DN399_20510 ENOG4105S1Z Stage IV sporulation protein B DN399_20515 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DN399_20520 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DN399_20525 ENOG4105DX0 Hemolysin A DN399_20535 ENOG4105CTB Polyprenyl synthetase DN399_20550 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DN399_20560 ENOG4108ZSR alkaline shock protein DN399_20565 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN399_20590 ENOG410644B Stage III sporulation protein af DN399_20600 ENOG4105KQ4 Stage iii sporulation protein ad DN399_20605 ENOG4108CQH stage III sporulation protein AC DN399_20610 ENOG4105KR5 Stage iii sporulation protein DN399_20615 ENOG4105CD2 stage iii sporulation protein aa DN399_20640 ENOG4105DC7 peptidase M24 DN399_20645 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DN399_20655 ENOG4105CBJ Metal-dependent enzyme DN399_20665 ENOG4107YBY Hydrolase DN399_20680 ENOG4105K7K Transcriptional regulator DN399_20695 ENOG41082GG biotin lipoate A B protein ligase DN399_20700 ENOG4105WZW rhodanese family DN399_20725 ENOG41080TC multidrug resistance protein DN399_20755 ENOG4105CJ1 ABC, transporter DN399_20760 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN399_20775 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DN399_20795 ENOG4105C0D helicase DN399_20845 ENOG4107UNZ domain protein DN399_20880 ENOG41063R6 DN399_20940 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN399_20945 ENOG4105C3R Methionine synthase DN399_20955 ENOG4105C28 cystathionine DN399_20960 ENOG4105C28 cystathionine DN399_20980 ENOG4105C5X domain protein DN399_20990 ENOG4105DKQ ROK family DN399_21000 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DN399_21015 ENOG4108UTW Plays a role in the regulation of phosphate uptake DN399_21020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DN399_21025 ENOG4105C8U phosphate abc transporter DN399_21030 ENOG4105C8U phosphate abc transporter DN399_21035 ENOG4105EXS phosphate abc transporter DN399_21040 ENOG4107RF6 penicillin-binding protein DN399_21050 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN399_21075 ENOG4105N80 Ferric uptake regulator, Fur family DN399_21085 ENOG4105FDK ABC transporter DN399_21090 ENOG4108JYZ YitT family DN399_21095 ENOG41069ZM Protein of unknown function (DUF2624) DN399_21120 ENOG4105EGD dinuclear metal center protein, YbgI family DN399_21135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN399_21140 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DN399_21165 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DN399_21170 ENOG4105KG3 cytidine deaminase DN399_21175 ENOG4107YR5 Diacylglycerol kinase DN399_21180 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DN399_21185 ENOG4105CTJ Metal Dependent Phosphohydrolase DN399_21190 ENOG4105C9A Phoh family DN399_21200 ENOG41068P3 sporulation protein YqfC DN399_21210 ENOG4105KTH gatB Yqey DN399_21225 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DN399_21230 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DN399_21260 ENOG4105CSA Coproporphyrinogen iii oxidase DN399_21265 ENOG4105KVH Transcriptional regulator DN399_21290 ENOG4105TQK DNA polymerase iii, delta' subunit DN399_21300 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DN399_21305 ENOG4108UK2 deaminase DN399_21310 ENOG4105KQC Competence protein DN399_21320 ENOG4105DXX methyltransferase DN399_21330 ENOG4108WF2 Metal Dependent Phosphohydrolase DN399_21340 ENOG410812S Rna-binding protein DN399_21350 ENOG4105CQW ribosome biogenesis GTPase YqeH DN399_21355 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DN399_21370 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN399_21390 ENOG4108TVJ Nitroreductase DN399_21405 ENOG4105G6Z alkaline phosphatase DN399_21410 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DN399_21415 ENOG4108MUZ hydrolase DN399_21450 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DN399_21455 ENOG4105MIR Phenylalanine 4-monooxygenase DN399_21465 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN399_21505 ENOG4105S6R Iron-hydroxamate transporter permease subunit DN399_21510 ENOG4108V5C ABC transporter DN399_21525 ENOG4108EKI Dehydrogenase DN399_21530 ENOG4105C28 cystathionine DN399_21560 ENOG4107XRG penicillin-binding protein DN399_21570 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DN399_21580 ENOG4105CFP Peptidase U32 DN399_21585 ENOG4105XYU peptidase (U32 family) DN399_21590 ENOG4108VQJ O-methyltransferase DN399_21595 ENOG4105HHA aminodeoxychorismate lyase DN399_21615 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN399_21625 ENOG4105C02 permease DN399_21640 ENOG41060CR DN399_21645 ENOG4105C7H Helicase, RecD TraA family DN399_21655 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DN399_21660 ENOG4105C3J Cysteine desulfurase DN399_21670 ENOG4105D1H recombination factor protein RarA DN399_21675 ENOG4108VCI transcription factor, rsfa family DN399_21690 ENOG4105CUZ uba thif-type nad fad binding protein DN399_21700 ENOG4105CUT histidyl-tRNA synthetase DN399_21705 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DN399_21710 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DN399_21720 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DN399_21725 ENOG41076HS cation diffusion facilitator family transporter DN399_21730 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DN399_21740 ENOG4105CKP Polysaccharide Biosynthesis Protein DN399_21745 ENOG4108QG2 Membrane DN399_21755 ENOG4105VIE preprotein translocase, subunit YajC DN399_21770 ENOG41061AI Protein of unknown function (DUF2905) DN399_21785 ENOG4108HUF Transporter DN399_21815 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DN399_21820 ENOG4108IYU L-aspartate oxidase DN399_21835 ENOG4108RPX mosc domain containing protein DN399_21840 ENOG4105CQC Prephenate dehydratase DN399_21855 ENOG4105C19 ABC transporter DN399_21860 ENOG4105EWM Histidine kinase DN399_21870 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DN399_21885 ENOG4105X36 (ribosomal) protein DN399_21895 ENOG4105C03 ribonuclease DN399_21910 ENOG4107QMS site-determining protein DN399_21925 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DN399_21930 ENOG4105DFF Rod shape-determining protein mreb DN399_21950 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DN399_21955 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DN399_21965 ENOG41068KH stage VI sporulation protein D DN399_21975 ENOG4105D52 delta-aminolevulinic acid dehydratase DN399_22000 ENOG4105K56 Transcriptional regulator DN399_22020 ENOG4108IUQ atp-dependent protease DN399_22045 ENOG4108QCI YvbH-like oligomerisation region DN399_22065 ENOG4105M59 Phosphodiesterase, mj0936 family DN399_22070 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DN399_22080 ENOG4108XJQ germination protein DN399_22095 ENOG4105PFC Transcriptional regulator DN399_22105 ENOG4105DZC cytosine deaminase DN399_22110 ENOG41067S9 phage shock protein C, PspC DN399_22115 ENOG4108JCI Transcriptional regulator DN399_22125 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DN399_22130 ENOG4108Z40 Transcriptional regulator DN399_22135 ENOG4105RHA ABC transporter, permease DN399_22140 ENOG4108IUX (ABC) transporter DN399_22145 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DN399_22150 ENOG4105ER2 Ompa motb domain protein DN399_22155 ENOG4105E14 MotA TolQ exbB proton channel DN399_22165 ENOG4108VXD carboxy-peptidase DN399_22175 ENOG4105E33 succinate dehydrogenase DN399_22185 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DN399_22195 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DN399_22200 ENOG4105K63 Thioredoxin DN399_22205 ENOG4105C10 Electron transfer flavoprotein DN399_22210 ENOG4105BZJ Electron transfer flavoprotein DN399_22215 ENOG41060WC Enoyl-CoA hydratase DN399_22220 ENOG4107Z3H Transcriptional regulator, TetR family DN399_22225 ENOG4105CEY Amp-dependent synthetase and ligase DN399_22235 ENOG4105J76 Periplasmic binding protein DN399_22240 ENOG4105S6R Iron-hydroxamate transporter permease subunit DN399_22290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN399_22300 ENOG4105DR4 Methyltransferase DN399_22310 ENOG4105KFN sortase, SrtB family DN399_22315 ENOG4105E0A ABC, transporter DN399_22330 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DN399_22340 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DN399_22350 ENOG4105FE9 pseudouridine synthase DN399_22360 ENOG4105DCG PHP domain protein DN399_22375 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DN399_22390 ENOG4105C5S asparaginyl-tRNA synthetase DN399_22395 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DN399_22405 ENOG4108RWN rrna methyltransferase DN399_22425 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN399_22430 ENOG4105CW7 secretion protein, HlyD family DN399_22435 ENOG4108JGH Tetr family transcriptional regulator DN399_22440 ENOG4105CN9 Peptidase m42 family protein DN399_22460 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DN399_22465 ENOG4105C22 threonyL-tRNA synthetase DN399_22470 ENOG4108TDW sporulation protein YtxC DN399_22495 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DN399_22500 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DN399_22505 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DN399_22515 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DN399_22520 ENOG4105C2M dna polymerase I DN399_22525 ENOG4105BZU Histidine kinase DN399_22530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN399_22545 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN399_22550 ENOG4108HMX isocitrate dehydrogenase (NADP) DN399_22555 ENOG4105BZN citrate synthase DN399_22570 ENOG4108REF Sporulation integral membrane protein ytvi DN399_22575 ENOG4105FS0 cytoplasmic membrane protein DN399_22600 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN399_22605 ENOG4105C6K Malic enzyme DN399_22610 ENOG4105C0B DNA polymerase III (alpha subunit) DN399_22615 ENOG4105VV2 DN399_22625 ENOG4105SFS phosphoesterase RecJ domain protein DN399_22645 ENOG4105E8R UPF0173 metal-dependent hydrolase DN399_22650 ENOG4105DC7 peptidase M24 DN399_22685 ENOG4105Z7P Acetyltransferase (GNAT) family DN399_22690 ENOG41082W1 Cupin 2, conserved barrel domain protein DN399_22710 ENOG4107YZX Universal stress protein DN399_22750 ENOG4108JYZ YitT family DN399_22770 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DN399_22780 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DN399_22785 ENOG4105KBJ sporulation protein ytfj DN399_22800 ENOG4105EFZ amidohydrolase DN399_22810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN399_22835 ENOG4105RQF LysR family Transcriptional regulator DN399_22845 ENOG4105U5Y Transcriptional regulator DN399_22855 ENOG4105C28 cystathionine DN399_22885 ENOG4108UW5 maltose o-acetyltransferase DN399_22895 ENOG4105F1V Acetoin utilization protein DN399_22900 ENOG4105W87 Cbs domain DN399_22905 ENOG4105DGU Histone deacetylase DN399_22920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN399_22930 ENOG4107SNB ankyrin repeat protein YahD DN399_22935 ENOG4105EP9 oxidoreductase DN399_22965 ENOG4105ETE Transcriptional regulator (LacI family DN399_22970 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN399_22990 ENOG4105C88 aminopeptidase DN399_23025 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN399_23035 ENOG4108VDD TRNA binding domain protein DN399_23065 ENOG4105C8F Beta-lactamase domain protein DN399_23080 ENOG4108V15 phosphotransferase enzyme family DN399_23085 ENOG4108IUM Glycogen debranching enzyme DN399_23095 ENOG4107QSE Dipeptidase DN399_23100 ENOG4105YW5 deoR family transcriptional regulator DN399_23115 ENOG4105CBX hi0933 family DN399_23155 ENOG4108VJ1 Transcriptional regulator (CarD family DN399_23160 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DN399_23165 ENOG4105CSC Glucose uptake protein DN399_23180 ENOG4108ZAF Molybdopterin DN399_23185 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DN399_23190 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN399_23200 ENOG4105D06 uba thif-type nad fad binding protein DN399_23205 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN399_23230 ENOG41085GJ domain protein DN399_23240 ENOG4105DWV Homoserine O-trans-acetylase DN399_23250 ENOG4108B31 Spore germination protein DN399_23275 ENOG4105C8T Leucyl-tRNA synthetase DN399_23280 ENOG410605W Major Facilitator DN399_23285 ENOG4107S91 Sodium hydrogen exchanger DN399_23290 ENOG4105NCW Trka-c domain protein DN399_23305 ENOG4105C19 ABC transporter DN399_23325 ENOG4105N5T Radical SAM Protein DN399_23355 ENOG4105E8V Alpha Beta Hydrolase Fold protein DN399_23360 ENOG4108Z0R Transferase DN399_23365 ENOG4105YVM Phosphoesterase, PA-phosphatase related DN399_23370 ENOG4105BZF Glycosyl transferase (Group 1 DN399_23380 ENOG4105EPU Molybdenum cofactor synthesis domain protein DN399_23390 ENOG4108MK9 spermidine N(1)-acetyltransferase DN399_23465 ENOG4105BZU Histidine kinase DN399_23470 ENOG4105BZU Histidine kinase DN399_23475 ENOG4105CH6 catalase DN399_23485 ENOG4107S9D Alpha beta hydrolase DN399_23490 ENOG4107T7U Sulfatase DN399_23505 ENOG4105D2X ABC transporter substrate-binding protein DN399_23515 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DN399_23585 ENOG4108V2W Carbonate dehydratase DN399_23590 ENOG4105C4M (Ubiquinol oxidase) subunit I DN399_23595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN399_23635 ENOG41087YS Phage shock protein A DN399_23665 ENOG4105BZU Histidine kinase DN399_23670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_23695 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN399_23700 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DN399_23765 ENOG4107ZTW SNARE associated Golgi DN399_23780 ENOG4105C19 ABC transporter DN399_23785 ENOG41086D8 Transcriptional regulator DN399_23800 ENOG41082BM Transcriptional regulator, arsr family DN399_23850 ENOG4105C6Z Gluconate DN399_23855 ENOG4105FDP GntR family transcriptional regulator DN399_23875 ENOG41069H0 dihydroorotase EC 3.5.2.3 DN399_23895 ENOG4105DTQ mandelate racemase muconate lactonizing DN399_23900 ENOG4105CEY Amp-dependent synthetase and ligase DN399_23905 ENOG4108IPT Naphthoate synthase DN399_23910 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DN399_23915 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DN399_23920 ENOG4105E4F Isochorismate synthase DN399_23925 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN399_23935 ENOG4105VEQ Cold shock protein DN399_23965 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DN399_23980 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DN399_23990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN399_23995 ENOG4108Q5F Tetr family transcriptional regulator DN399_24095 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DN399_24130 ENOG4105KT7 mgtC SapB transporter DN399_24135 ENOG4107PBV potassium channel DN399_24155 ENOG4105WG9 Conserved Protein DN399_24165 ENOG4105CHM Aminotransferase DN399_24170 ENOG4108ZB6 transcriptional regulator AsnC family DN399_24175 ENOG4105C5I Dehydrogenase DN399_24180 ENOG4108MUZ hydrolase DN399_24190 ENOG4105C87 Aminotransferase class I and II DN399_24200 ENOG4105Y38 Kinase-associated protein B DN399_24210 ENOG4107R3E Citrate transporter DN399_24225 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DN399_24230 ENOG4105KA0 thioesterase Superfamily protein DN399_24245 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN399_24270 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) DN399_24275 ENOG4106YN8 Prenyltransferase DN399_24285 ENOG41069ER domain protein DN399_24300 ENOG4105CEP NADH dehydrogenase DN399_24330 ENOG4105EWC Purine nucleoside phosphorylase DN399_24350 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DN399_24375 ENOG4108JJA ABC, transporter DN399_24380 ENOG4105C4B ABC transporter, permease DN399_24385 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DN399_24440 ENOG41083MR nifu domain-containing protein DN399_24455 ENOG4108W5N phosphatidylglycerophosphatase a DN399_24475 ENOG4105DAX Pfam:DUF2983 DN399_24490 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN399_24495 ENOG4105D4U had-superfamily hydrolase, subfamily iia DN399_24510 ENOG4105CBT Fructose-1,6-bisphosphatase DN399_24535 ENOG4105MMD transcriptional regulator DN399_24540 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DN399_24545 ENOG4107TXC Transcriptional regulator DN399_24550 ENOG41090T1 Membrane DN399_24575 ENOG4105FAA peptidase M23 DN399_24580 ENOG4108YTE sporulation protein YunB DN399_24585 ENOG4105KZD Domain of unknown function (DUF1805) DN399_24590 ENOG4107R8B 5'-nucleotidase DN399_24600 ENOG4105DIW FeS assembly protein SUFB DN399_24605 ENOG4108UNV SUF system FeS assembly protein, NifU family DN399_24610 ENOG4105C9B Cysteine desulfurase DN399_24615 ENOG4105JRK feS assembly protein SufD DN399_24620 ENOG4105C3K feS assembly ATPase SufC DN399_24625 ENOG4105D01 (LipO)protein DN399_24630 ENOG4105D01 (LipO)protein DN399_24635 ENOG4108UMI ABC transporter, permease DN399_24665 ENOG41080E8 Transcriptional regulator, Spx MgsR family DN399_24685 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN399_24710 ENOG4108W8B Beta-lactamase domain protein DN399_24715 ENOG4105C1G acyl-Coa dehydrogenase DN399_24720 ENOG4105CHU acetyl-coa acetyltransferase DN399_24735 ENOG4105DZ1 carboxypeptidase DN399_24755 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN399_24765 ENOG4108SUT Major Facilitator Superfamily DN399_24770 ENOG4107R7I amino acid DN399_24785 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN399_24795 ENOG4107AYK membrAne DN399_24835 ENOG4107ZTW SNARE associated Golgi DN399_24845 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN399_24850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_24855 ENOG4105BZU Histidine kinase DN399_24870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN399_24885 ENOG4105C8Q Methyl-accepting chemotaxis DN399_24890 ENOG4105VG1 fes assembly suf system protein DN399_24895 ENOG4105D4Y metalloprotease DN399_24900 ENOG4105C2I pirin domain protein DN399_24915 ENOG4107T5V SNARE associated Golgi DN399_24920 ENOG4107S91 Sodium hydrogen exchanger DN399_24925 ENOG4105NCW Trka-c domain protein DN399_24935 ENOG4108RMU ferritin dps family protein DN399_24960 ENOG4108URH decarboxylase DN399_24970 ENOG41090A1 ferritin DN399_24980 ENOG4105D9N nucleoside DN399_24985 ENOG4105D9N nucleoside DN399_25000 ENOG4108RYK Nad-dependent epimerase dehydratase DN399_25015 ENOG4105CV8 reductase DN399_25020 ENOG4105F27 Major Facilitator DN399_25025 ENOG4105KVH Transcriptional regulator DN399_25040 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DN399_25045 ENOG4105D4A Cell wall formation (By similarity) DN399_25055 ENOG4105C8Q Methyl-accepting chemotaxis DN399_25065 ENOG4105WMR Protein CrcB homolog DN399_25070 ENOG4105WMR Protein CrcB homolog DN399_25085 ENOG4108MK9 spermidine N(1)-acetyltransferase DN399_25090 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DN399_25120 ENOG4108IPW abc transporter atp-binding protein DN399_25125 ENOG4105CM4 permease protein DN399_25175 ENOG4105EWM Histidine kinase DN399_25180 ENOG4105CJZ response regulator DN399_25185 ENOG4105C19 ABC transporter DN399_25205 ENOG4105C19 ABC transporter DN399_25240 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DN399_25250 ENOG4105XZU Preprotein translocase, subunit SecG DN399_25255 ENOG41067MG lrgb family DN399_25305 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN399_25325 ENOG41090VF Stage v sporulation protein ac DN399_25330 ENOG4105CZ3 stage V sporulation protein ad DN399_25345 ENOG4108QY0 Membrane DN399_25350 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN399_25355 ENOG4105KRI phosphocarrier protein (HPr DN399_25365 ENOG4105CHW UPF0052 protein DN399_25370 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DN399_25375 ENOG4108Z4K mutator MutT protein DN399_25385 ENOG4105C3M thioredoxin reductase DN399_25395 ENOG4108S4C acetyltransferase DN399_25415 ENOG41086DT Membrane protein of unknown function DN399_25425 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DN399_25430 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DN399_25445 ENOG4107TXC Transcriptional regulator DN399_25460 ENOG4105HMI Membrane DN399_25465 ENOG4105DUM transcriptional regulator, lysR family DN399_25475 ENOG4108WS4 fmn reductase DN399_25490 ENOG4105BZ1 (ABC) transporter DN399_25500 ENOG4105CN1 protease DN399_25505 ENOG4105CRP Part of the ABC transporter FtsEX involved in DN399_25510 ENOG4105CAK Cell division ATP-binding protein ftsE DN399_25535 ENOG4105MS2 ribosomal subunit Interface protein DN399_25540 ENOG4105VEQ Cold shock protein DN399_25545 ENOG41081UC Inherit from COG: Competence protein DN399_25560 ENOG4105KVH Transcriptional regulator DN399_25570 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DN399_25575 ENOG4108KGH TRANSCRIPTIONal DN399_25580 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DN399_25585 ENOG4105C6Y Udp-glucose 6-dehydrogenase DN399_25590 ENOG4105ESV Glycosyl transferase, family 4 DN399_25600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DN399_25620 ENOG4105F8D glycoside hydrolase family 4 DN399_25625 ENOG4105VCP PTS System DN399_25630 ENOG4105CK1 PTS System DN399_25640 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DN399_25645 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DN399_25650 ENOG4105VCP PTS System DN399_25660 ENOG4105VZJ PTS System DN399_25680 ENOG4105ECB domain protein DN399_25685 ENOG4107RSM transcriptional regulator DN399_25735 ENOG4105DAA L-lactate DN399_25745 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DN399_25760 ENOG4105E0M Sulfatase DN399_25785 ENOG4107R8N Glycosyl transferase, family 2 DN399_25790 ENOG4105C94 Transporter DN399_25800 ENOG41069ER domain protein DN399_25830 ENOG4105KBK Zinc finger, swim domain protein DN399_25835 ENOG4105C0D helicase DN399_25865 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN399_25875 ENOG4107RBB ABC transporter, permease DN399_25880 ENOG4105C19 ABC transporter DN399_25900 ENOG4105CXY transporter DN399_25915 ENOG4105BZU Histidine kinase DN399_25920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_25930 ENOG4108KGH TRANSCRIPTIONal DN399_25940 ENOG4105C6Y Udp-glucose 6-dehydrogenase DN399_25945 ENOG4108SHN Glycosyl transferase, family 2 DN399_25965 ENOG4105E2K Glycosyl transferase (Group 1 DN399_25970 ENOG4107SBE Glycosyl transferase (Group 1 DN399_25975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DN399_25985 ENOG4105C5E polysaccharide biosynthesis protein DN399_25995 ENOG4105D7W serine acetyltransferase DN399_26000 ENOG4105D3Q Sugar transferase DN399_26005 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DN399_26015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN399_26020 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DN399_26025 ENOG4107YJ4 chain length determinant protein DN399_26030 ENOG4105HTX biosynthesis protein DN399_26035 ENOG4108QV3 biosynthesis protein DN399_26050 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DN399_26060 ENOG4105FRN stage II sporulation protein DN399_26075 ENOG4105DY9 regulatoR DN399_26095 ENOG4106778 Protein of unknown function (DUF1146) DN399_26100 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN399_26105 ENOG4105C8S subunit m DN399_26110 ENOG4105D65 subunit l DN399_26135 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN399_26140 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN399_26150 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN399_26155 ENOG4105BZU Histidine kinase DN399_26205 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DN399_26210 ENOG41062M3 atp synthase DN399_26230 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DN399_26235 ENOG4108UIC UPF0340 protein DN399_26240 ENOG4108YZG isomerase DN399_26255 ENOG4108VGI doxx family DN399_26260 ENOG4107XC4 flavin reductase domain protein, FMN-binding DN399_26275 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DN399_26285 ENOG4108ZXQ stage ii sporulation protein r DN399_26290 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DN399_26295 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DN399_26300 ENOG4107104 thymidine kinase DN399_26315 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DN399_26320 ENOG4105CBT Fructose-1,6-bisphosphatase DN399_26325 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DN399_26345 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DN399_26360 ENOG4105C1G acyl-Coa dehydrogenase DN399_26365 ENOG4105C1G acyl-Coa dehydrogenase DN399_26370 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DN399_26380 ENOG4105DF6 Fe-S oxidoreductase DN399_26395 ENOG4105BZU Histidine kinase DN399_26410 ENOG4105D4Y metalloprotease DN399_26420 ENOG4105BZU Histidine kinase DN399_26425 ENOG4105KCT ABC transporter DN399_26430 ENOG4108M15 ABC transporter DN399_26435 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DN399_26445 ENOG4105IIU Aminopeptidase DN399_26470 ENOG410684U Domain of unknown function (DUF1934) DN399_26490 ENOG4105CYW agmatinase DN399_26500 ENOG4105DXB Major Facilitator superfamily DN399_26505 ENOG4107SWG transcriptional regulator MERR family DN399_26510 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN399_26515 ENOG4105BZ4 penicillin-binding protein DN399_26520 ENOG4108XFG YwhD family DN399_26525 ENOG4108Z4T Peptidase M50 DN399_26530 ENOG41069HH 4-oxalocrotonate tautomerase DN399_26535 ENOG4105DCI Phosphohydrolase DN399_26540 ENOG4108MES Periplasmic binding protein DN399_26545 ENOG4105E0A ABC, transporter DN399_26550 ENOG4105EHG Permease protein DN399_26555 ENOG4105DQ5 transport system permease protein DN399_26565 ENOG4108VCI transcription factor, rsfa family DN399_26570 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DN399_26575 ENOG4108IJ2 phosphate acetyltransferase DN399_26580 ENOG4107UEZ chlorite dismutase DN399_26590 ENOG4108VKI Cell wall hydrolase DN399_26610 ENOG4107SVH Potassium channel protein DN399_26620 ENOG410667J hydrolase DN399_26625 ENOG4105VCH membrane DN399_26635 ENOG4108TU7 Inherit from COG: (ABC) transporter DN399_26640 ENOG4105CJ1 ABC, transporter DN399_26645 ENOG41090WU lipolytic protein G-D-S-L family DN399_26660 ENOG4105D6E homoserine dehydrogenase DN399_26685 ENOG4108Y4K DNA-binding transcriptional activator DN399_26695 ENOG4105WH1 Two component transcriptional regulator luxr family DN399_26700 ENOG4105BZU Histidine kinase DN399_26705 ENOG4105DWF phosphomethylpyrimidine kinase DN399_26710 ENOG4105BZU Histidine kinase DN399_26715 ENOG4105VCD cytoplasmic protein DN399_26720 ENOG4105D22 carbon starvation protein DN399_26725 ENOG4105DY9 regulatoR DN399_26730 ENOG41079KZ Major Facilitator Superfamily DN399_26745 ENOG4105CG5 Glycosyl transferase (Group 1 DN399_26755 ENOG4105EN6 Membrane DN399_26760 ENOG4106YBV Methyl-accepting chemotaxis DN399_26770 ENOG4108S4H thioesterase Superfamily protein DN399_26780 ENOG4105K64 Glycosyl transferase, family 2 DN399_26795 ENOG4105CKK Glycosyl transferase, family 2 DN399_26800 ENOG4105C5H ABC transporter DN399_26805 ENOG41067SE Tetr family transcriptional regulator DN399_26815 ENOG4105E0X reductase DN399_26820 ENOG4106F5Q Membrane DN399_26835 ENOG4108NEV two component transcriptional regulator, LytTR family DN399_26840 ENOG4108HRK Histidine kinase DN399_26845 ENOG4107RGD Major Facilitator superfamily DN399_26865 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN399_26875 ENOG4105IW1 AmiS UreI transporter DN399_26885 ENOG4105CMR udp-glucose 4-epimerase DN399_26890 ENOG4108UT2 hemolysin iii DN399_26900 ENOG4105C1J atp-dependent rna helicase DN399_26905 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DN399_26910 ENOG4105DPN Oligoendopeptidase f DN399_26920 ENOG4105BZU Histidine kinase DN399_26925 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DN399_26935 ENOG4105C0H protease DN399_26940 ENOG4105Q2H domain protein DN399_26955 ENOG4105BZU Histidine kinase DN399_26960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN399_26985 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DN399_26990 ENOG4105CDU Replicative dna helicase DN399_27000 ENOG4105BZR domain protein DN399_27005 ENOG4108XMW Membrane DN399_27015 ENOG4108UUM single-stranded DNA-binding protein DN399_27025 ENOG4105C3G gtp-binding protein DN399_27030 ENOG4105VDK protein, conserved in bacteria DN399_27035 ENOG4105D8X mechanosensitive ion channel DN399_27040 ENOG4108ZDA Sporulation protein YyaC DN399_27045 ENOG4105FA0 parb-like partition protein DN399_27050 ENOG4107QJE Chromosome Partitioning Protein DN399_27065 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DN399_27070 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DN399_27080 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN399_27125 ENOG4107JM4 Tetratricopeptide repeat DN399_27310 ENOG4105K4H Nlp p60 protein DN399_27380 ENOG4105C9U ATP-dependent DNA helicase RecQ DN399_27410 ENOG4107QI6 Cysteine desulfurase DN399_27465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DN399_27520 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DN399_27535 ENOG4108J59 Extracellular solute-binding protein, family 5 DN399_27565 ENOG4105K4H Nlp p60 protein DN399_27580 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN399_27740 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DN399_27865 ENOG4105K4H Nlp p60 protein DN399_27895 ENOG4105C9U ATP-dependent DNA helicase RecQ DN399_27905 ENOG4105BZU Histidine kinase DN399_27935 ENOG4107QJE Chromosome Partitioning Protein