locus-tag class description F0362_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F0362_00015 ENOG410848D S4 domain protein YaaA F0362_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0362_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F0362_00100 ENOG4105ZMH deoxynucleoside kinase F0362_00110 ENOG4105GTG Isochorismatase F0362_00120 ENOG4108Z6B deaminase F0362_00130 ENOG4105C6E dna polymerase iii F0362_00150 ENOG41067KS pro-sigma K processing F0362_00185 ENOG4105CXN decarboxylase F0362_00195 ENOG4105FA2 dna polymerase iii F0362_00200 ENOG4105MA4 psp1 domain protein F0362_00210 ENOG41060K3 Methyltransferase F0362_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) F0362_00225 ENOG4105KRN Transcriptional regulator, abrb family F0362_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F0362_00235 ENOG4105F8V Hydrolase, tatD family F0362_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) F0362_00245 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) F0362_00250 ENOG4105XFA sporulation peptidase YabG F0362_00255 ENOG4105W42 Veg protein F0362_00270 ENOG4105DFT pur operon repressor F0362_00275 ENOG4105KME endoribonuclease L-psp F0362_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase F0362_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F0362_00305 ENOG4108JA2 transcriptioN-repair coupling factor F0362_00310 ENOG4108M14 stage v sporulation protein t F0362_00320 ENOG4108IY2 MazG family F0362_00325 ENOG41082I2 s4 domain protein F0362_00330 ENOG4105VYY sporulation protein yabp F0362_00345 ENOG41060GV RNA binding s1 domain protein F0362_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase F0362_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F0362_00390 ENOG4105C6T cysteine synthase F0362_00395 ENOG4105CRQ synthase (Component I) F0362_00400 ENOG4105DDQ anthranilate synthase F0362_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 F0362_00410 ENOG4105EEI dihydropteroate synthase F0362_00415 ENOG4105KRF dihydroneopterin aldolase F0362_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F0362_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F0362_00525 ENOG4108Z0C Uvrb UvrC protein F0362_00540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F0362_00550 ENOG4105CTP PilT protein domain protein F0362_00570 ENOG4105D7W serine acetyltransferase F0362_00585 ENOG4105C2N RNA methyltransferase TrmH family group 3 F0362_00590 ENOG4105M0M Tetracycline resistance protein F0362_00595 ENOG4105QIV RNA polymerase F0362_00610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F0362_00620 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) F0362_00630 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) F0362_00635 ENOG4107Y49 methyltransferase F0362_00650 ENOG4105XPM ribosomal protein F0362_00755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) F0362_00770 ENOG4105VPB 50S ribosomal protein L30 F0362_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F0362_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F0362_00800 ENOG41067V7 50S ribosomal protein L36 F0362_00830 ENOG4108JJB ABC transporter F0362_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) F0362_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F0362_00865 ENOG4105D1F ATP-binding protein F0362_00880 ENOG4108NMV polysaccharide deacetylase F0362_00960 ENOG4105C8B TIGR00159 family F0362_00965 ENOG4107U5W ybbr family F0362_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F0362_01005 ENOG4108PSK reductase F0362_01010 ENOG4108UMI ABC transporter, permease F0362_01020 ENOG4105D01 (LipO)protein F0362_01025 ENOG4105EE1 crotonyl-CoA reductase F0362_01035 ENOG4105IQ5 FAD linked oxidase domain protein F0362_01050 ENOG4105C2C drug resistance transporter, Bcr CflA F0362_01065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F0362_01070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0362_01075 ENOG4105C3U ABC transporter F0362_01080 ENOG4108JQ7 (ABC) transporter F0362_01110 ENOG4108J59 Extracellular solute-binding protein, family 5 F0362_01115 ENOG4108J59 Extracellular solute-binding protein, family 5 F0362_01130 ENOG4106Z1T Nicotinamide Mononucleotide Transporter F0362_01140 ENOG4105E0C molybdate abc transporter F0362_01145 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F0362_01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family F0362_01180 ENOG4105F6E Acyl-transferase F0362_01200 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) F0362_01215 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) F0362_01235 ENOG4105C5H ABC transporter F0362_01245 ENOG4105DEF Extracellular solute-binding protein, family 5 F0362_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0362_01260 ENOG4105C3U ABC transporter F0362_01265 ENOG4108JQ7 (ABC) transporter F0362_01270 ENOG410667J hydrolase F0362_01300 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase F0362_01305 ENOG4105ERH Fumarylacetoacetate hydrolase F0362_01315 ENOG4105CUB amino acid F0362_01320 ENOG4108SC4 )-transporter F0362_01325 ENOG4105CPF Cell wall formation (By similarity) F0362_01330 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) F0362_01355 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein F0362_01360 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F0362_01370 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) F0362_01475 ENOG4105K8N protein family UPF0079, ATPase F0362_01480 ENOG41072GX Peptidase M22 Glycoprotease F0362_01485 ENOG410801F ribosomal-protein-alanine acetyltransferase F0362_01490 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F0362_01495 ENOG4105C5H ABC transporter F0362_01510 ENOG4108TYN CAAX amino terminal protease family protein F0362_01520 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) F0362_01535 ENOG4105C7N Xanthine uracil vitamin C permease F0362_01545 ENOG4105BZU Histidine kinase F0362_01570 ENOG4107ZXU DSBA oxidoreductase F0362_01600 ENOG4107ZXU DSBA oxidoreductase F0362_01670 ENOG4105SX7 Transporter F0362_01725 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0362_01750 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F0362_01755 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F0362_01760 ENOG4105C83 adenylosuccinate lyase F0362_01770 ENOG4105VR9 phosphoribosylformylglycinamidine synthase F0362_01795 ENOG4108V3E phosphoribosylglycinamide formyltransferase F0362_01800 ENOG4105DC1 bifunctional purine biosynthesis protein purh F0362_01805 ENOG4105C12 Phosphoribosylglycinamide synthetase F0362_01830 ENOG4105C4R Atp-dependent dna helicase F0362_01855 ENOG4108W2Y isochorismatase F0362_01865 ENOG4108UMI ABC transporter, permease F0362_01870 ENOG4105D01 (LipO)protein F0362_01890 ENOG410834F Transcriptional regulator F0362_01895 ENOG4107I77 yiaA/B two helix domain F0362_01915 ENOG4105CBD Diacylglycerol kinase F0362_01920 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F0362_01925 ENOG4108JPW Aminotransferase F0362_01935 ENOG4105C26 Dehydrogenase F0362_01940 ENOG4105KPY Small multidrug resistance protein F0362_01965 ENOG4105D9N nucleoside F0362_01970 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F0362_01980 ENOG4105BZU Histidine kinase F0362_01990 ENOG4108W15 Protein of unknown function (DUF1456) F0362_02010 ENOG4105DTQ mandelate racemase muconate lactonizing F0362_02020 ENOG4105DFD Na H antiporter F0362_02040 ENOG4105D3R alkyl hydroperoxide reductase F0362_02045 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) F0362_02055 ENOG4107W7X Aldolase F0362_02060 ENOG4105EHG Permease protein F0362_02065 ENOG4105DQ5 transport system permease protein F0362_02070 ENOG4108V5C ABC transporter F0362_02080 ENOG4105CAY ferredoxin--nadp reductase F0362_02095 ENOG4106UIA F0362_02100 ENOG4106UIA F0362_02115 ENOG4105BZU Histidine kinase F0362_02135 ENOG410756H nucleotidyltransferase F0362_02140 ENOG4105D2S major facilitator superfamily F0362_02155 ENOG4105E5Q amino acid AbC transporter F0362_02160 ENOG4105EAB amino acid AbC transporter F0362_02170 ENOG4105C8Q Methyl-accepting chemotaxis F0362_02185 ENOG4105DBV ornithine carbamoyltransferase F0362_02195 ENOG4105C5B carbamate kinase F0362_02210 ENOG4105DNP FAD linked oxidase domain protein F0362_02220 ENOG4105CI1 PTS System F0362_02235 ENOG4105C9U ATP-dependent DNA helicase RecQ F0362_02250 ENOG4105C7B Threonine dehydratase F0362_02255 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F0362_02275 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F0362_02320 ENOG41062JF Transcriptional regulator F0362_02340 ENOG4105DEU major facilitator superfamily F0362_02375 ENOG4108N0M stress protein F0362_02380 ENOG4106FN3 tellurium resistance protein F0362_02385 ENOG4106FN3 tellurium resistance protein F0362_02390 ENOG4107TS3 membrane protein, TerC F0362_02395 ENOG4108TTB tellurium resistance protein F0362_02415 ENOG4105KJF protein tyrosine phosphatase F0362_02425 ENOG4107U9T Pfam:Ribonuclease_BN F0362_02430 ENOG4105C59 p-type ATPase F0362_02435 ENOG4108IPJ Membrane F0362_02455 ENOG4107ZTW SNARE associated Golgi F0362_02470 ENOG410606W general stress protein F0362_02475 ENOG4105UPD Calcium Proton F0362_02515 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F0362_02525 ENOG4108JUB Transcriptional regulator F0362_02535 ENOG4108IQI permease F0362_02560 ENOG4105CSV Glutaminase F0362_02575 ENOG4108A04 Beta-lactamase F0362_02595 ENOG4105CKK Glycosyl transferase, family 2 F0362_02600 ENOG4107QQG Dehydrogenase F0362_02605 ENOG4105C3I Nad-dependent epimerase dehydratase F0362_02610 ENOG4105CKK Glycosyl transferase, family 2 F0362_02620 ENOG4105C6N Formate acetyltransferase F0362_02625 ENOG4105F1A Pyruvate formate-lyase F0362_02645 ENOG4105CI2 imidazolone-5-propionate hydrolase F0362_02650 ENOG4105ECP epimerase F0362_02680 ENOG41067AE Membrane-bound metal-dependent hydrolase F0362_02685 ENOG4105CEN a g-specific adenine glycosylase F0362_02690 ENOG4106BXE F0362_02710 ENOG4105BZ1 (ABC) transporter F0362_02715 ENOG4107NBY Membrane F0362_02720 ENOG4105CBC glutamate synthase F0362_02730 ENOG4108IUW ABC transporter F0362_02750 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F0362_02755 ENOG4105G5W regulator Fur family F0362_02875 ENOG4108JQC penicillin-binding protein 1A F0362_02880 ENOG4108R9S DSBA oxidoreductase F0362_02890 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F0362_02900 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F0362_02910 ENOG4105CYN Serine protein kinase F0362_02915 ENOG4106AKX UPF0229 protein F0362_02935 ENOG4105DZ6 Band 7 protein F0362_02945 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F0362_02950 ENOG4108V9W transcriptional regulatory protein F0362_02955 ENOG4105D4T Citrate transporter F0362_02980 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator F0362_02985 ENOG4108IJ9 (ABC) transporter F0362_02990 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component F0362_02995 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component F0362_03000 ENOG4105BZ7 extracellular solute-binding protein family 1 F0362_03005 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F0362_03010 ENOG4108STX response regulator F0362_03015 ENOG4105US7 Histidine kinase F0362_03040 ENOG4108MRH transcriptional regulatory protein F0362_03050 ENOG4105C6K Malic enzyme F0362_03060 ENOG4108UZ3 Transporter F0362_03065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0362_03080 ENOG4105BZU Histidine kinase F0362_03085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_03090 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) F0362_03095 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F0362_03100 ENOG4108JB9 formate dehydrogenase F0362_03120 ENOG4105CUB amino acid F0362_03135 ENOG4105C59 p-type ATPase F0362_03140 ENOG4105DAP Nicotinate phosphoribosyltransferase F0362_03175 ENOG41073R8 VanW family F0362_03180 ENOG4108KGH TRANSCRIPTIONal F0362_03185 ENOG4105D9N nucleoside F0362_03190 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase F0362_03195 ENOG4105C37 (CBS) domain F0362_03200 ENOG4108IJ0 Aspartate ammonia-lyase F0362_03205 ENOG4105DAA L-lactate F0362_03220 ENOG4105DUX Transporter F0362_03225 ENOG4108MES Periplasmic binding protein F0362_03230 ENOG4105DQ5 transport system permease protein F0362_03235 ENOG4108IHU transport system permease protein F0362_03240 ENOG4105E0A ABC, transporter F0362_03245 ENOG4105DMQ Methyltransferase F0362_03250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F0362_03255 ENOG4105EXW epimerase dehydratase F0362_03265 ENOG4107T89 von Willebrand factor, type A F0362_03270 ENOG4105GMT ATPase associated with various cellular activities aaa_5 F0362_03275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F0362_03285 ENOG4105BZU Histidine kinase F0362_03290 ENOG4105D5Q Arginine ornithine antiporter F0362_03295 ENOG4107414 GntR family transcriptional regulator F0362_03300 ENOG4105C5Y PTS System F0362_03305 ENOG4105CG3 alpha amylase, catalytic region F0362_03320 ENOG4105E1K spore germination protein F0362_03325 ENOG4105BZU Histidine kinase F0362_03330 ENOG4105WH1 Two component transcriptional regulator luxr family F0362_03335 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F0362_03345 ENOG4105CRN Aminoglycoside phosphotransferase F0362_03350 ENOG4105BZG amino acid carrier protein F0362_03355 ENOG4105CDA abc transporter atp-binding protein F0362_03360 ENOG4105CT1 (ABC) transporter F0362_03365 ENOG4105EAD ABC transporter F0362_03370 ENOG4105DRP amino acid AbC transporter F0362_03375 ENOG4108IQI permease F0362_03390 ENOG4105GFR rna polymerase sigma factor F0362_03400 ENOG4105D29 Helix-turn-helix type 11 domain protein F0362_03405 ENOG4105NAE bifunctional deaminase-reductase domain protein F0362_03410 ENOG4105BZU Histidine kinase F0362_03425 ENOG4105CHH sulfate transporter F0362_03430 ENOG41068KF Universal stress protein F0362_03440 ENOG4105CXY transporter F0362_03445 ENOG41067TZ transcriptional regulator, MarR family F0362_03450 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0362_03455 ENOG4105ETE Transcriptional regulator (LacI family F0362_03460 ENOG4108RVA ribokinase F0362_03470 ENOG4105C2J ABC transporter F0362_03475 ENOG4105CNN ABC, transporter F0362_03480 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F0362_03485 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F0362_03525 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) F0362_03560 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer F0362_03565 ENOG41069ER domain protein F0362_03570 ENOG4105VZ8 Transcriptional regulator F0362_03575 ENOG4107D63 F0362_03590 ENOG4105DUX Transporter F0362_03610 ENOG4105C85 amino acid F0362_03615 ENOG4105C7N Xanthine uracil vitamin C permease F0362_03650 ENOG4105CCU oxidase (Subunit III) F0362_03655 ENOG4105BZ9 Cytochrome C oxidase, subunit I F0362_03660 ENOG4105E2S oxidase) subunit II F0362_03680 ENOG4106CAD Protein of unknown function (DUF3311) F0362_03685 ENOG4105E1V na solute symporter F0362_03700 ENOG4108NHD germination protein F0362_03705 ENOG4105CE1 Ferrous iron transport protein b F0362_03710 ENOG4105CE1 Ferrous iron transport protein b F0362_03715 ENOG4105CE1 Ferrous iron transport protein b F0362_03720 ENOG4105CVA phosphate F0362_03725 ENOG4105C8U phosphate abc transporter F0362_03730 ENOG4105E2Z phosphate ABC transporter (Permease F0362_03860 ENOG41080XQ Signal transduction protein with cbs domains F0362_03880 ENOG4105ETU transcriptional activator (TenA F0362_03890 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F0362_03900 ENOG4108VEU Thiamine monophosphate synthase F0362_03905 ENOG41080HI glycine oxidase F0362_03920 ENOG4105D06 uba thif-type nad fad binding protein F0362_03925 ENOG4105DWF phosphomethylpyrimidine kinase F0362_03950 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F0362_03955 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) F0362_03960 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) F0362_03975 ENOG4108INS Transcriptional regulator F0362_03990 ENOG4105CNN ABC, transporter F0362_04005 ENOG4105C7N Xanthine uracil vitamin C permease F0362_04015 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F0362_04030 ENOG4105K63 Thioredoxin F0362_04050 ENOG4108B31 Spore germination protein F0362_04070 ENOG4107Y03 Nitroreductase F0362_04075 ENOG4105ED1 spovr family F0362_04090 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase F0362_04095 ENOG4105XTG Pfam:DUF156 F0362_04100 ENOG4105VFE sira family F0362_04105 ENOG4107TPS domain protein F0362_04110 ENOG4105VFE sira family F0362_04115 ENOG4105VFE sira family F0362_04120 ENOG41085GJ domain protein F0362_04125 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase F0362_04130 ENOG41087NI Sulfite exporter TauE/SafE F0362_04140 ENOG4108KGH TRANSCRIPTIONal F0362_04155 ENOG4105CZM Major Facilitator F0362_04170 ENOG4105EMD TRANSCRIPTIONal F0362_04175 ENOG4105VCP PTS System F0362_04180 ENOG4105VZJ PTS System F0362_04200 ENOG41069ER domain protein F0362_04205 ENOG4107RBB ABC transporter, permease F0362_04210 ENOG4105C19 ABC transporter F0362_04240 ENOG4105WEF catalase F0362_04255 ENOG4108UYE Lactoylglutathione lyase F0362_04275 ENOG4107T5V SNARE associated Golgi F0362_04310 ENOG4105CUB amino acid F0362_04315 ENOG4107RWR Sodium hydrogen exchanger F0362_04325 ENOG4106KNT transcriptional regulator F0362_04365 ENOG4108YXU transcriptional regulator AsnC family F0362_04395 ENOG4105KPY Small multidrug resistance protein F0362_04400 ENOG4105KPY Small multidrug resistance protein F0362_04425 ENOG4105NF4 modulator of drug activity F0362_04435 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) F0362_04440 ENOG4105E5W Transporter F0362_04450 ENOG4107RKG DJ-1/PfpI family F0362_04460 ENOG4105D5Q Arginine ornithine antiporter F0362_04465 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) F0362_04470 ENOG4105C26 Dehydrogenase F0362_04485 ENOG4105BZ1 (ABC) transporter F0362_04490 ENOG4105BZ1 (ABC) transporter F0362_04505 ENOG4105DRP amino acid AbC transporter F0362_04510 ENOG4105CDA abc transporter atp-binding protein F0362_04525 ENOG410839P F0362_04550 ENOG4107FQX Alpha-acetolactate decarboxylase F0362_04570 ENOG4105D4P Coproporphyrinogen iii oxidase F0362_04585 ENOG4105CHH sulfate transporter F0362_04595 ENOG4105CGU Enoyl-CoA hydratase F0362_04620 ENOG4105DER m42 family F0362_04645 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) F0362_04650 ENOG4105D5U fad dependent oxidoreductase F0362_04665 ENOG4105PFC Transcriptional regulator F0362_04690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0362_04700 ENOG4108JQ7 (ABC) transporter F0362_04740 ENOG4108IBT Inherit from COG: transposase F0362_04870 ENOG4105CSH Transporter F0362_04880 ENOG4108MRH transcriptional regulatory protein F0362_04915 ENOG4107RRE RNA-directed DNA polymerase F0362_04935 ENOG4105CDU Replicative dna helicase F0362_04940 ENOG4105C26 Dehydrogenase F0362_04960 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0362_05000 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase F0362_05010 ENOG4105CID antiterminator F0362_05015 ENOG4105C5Y PTS System F0362_05020 ENOG4105CS2 ec 3.2.1.21 F0362_05030 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F0362_05055 ENOG4105F27 Major Facilitator F0362_05060 ENOG4105WAB arsR family transcriptional regulator F0362_05075 ENOG4105CMT Dihydroxyacetone kinase F0362_05090 ENOG4105CMT Dihydroxyacetone kinase F0362_05100 ENOG410847I Transcriptional regulator, BadM Rrf2 family F0362_05115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_05120 ENOG41062D9 Histidine kinase F0362_05175 ENOG4105WN5 stage II sporulation protein F0362_05185 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0362_05195 ENOG4108MJI response regulator F0362_05200 ENOG4105BZU Histidine kinase F0362_05205 ENOG4105BZU Histidine kinase F0362_05230 ENOG4105DJ2 Major Facilitator Superfamily F0362_05235 ENOG4105C6F GntR Family Transcriptional Regulator F0362_05270 ENOG4107VRP DNA repair exonuclease F0362_05275 ENOG4106D4I domain protein F0362_05295 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F0362_05325 ENOG4108MUZ hydrolase F0362_05335 ENOG41067QW Transcriptional regulator F0362_05340 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator F0362_05355 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F0362_05370 ENOG4105EEM helicase F0362_05375 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F0362_05405 ENOG4105K59 histidine triad (HIT) protein F0362_05435 ENOG410905X membrane-flanked domain protein F0362_05440 ENOG4105CKV Membrane F0362_05485 ENOG410905X membrane-flanked domain protein F0362_05490 ENOG4105CKV Membrane F0362_05495 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation F0362_05500 ENOG4105BZ4 penicillin-binding protein F0362_05510 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F0362_05515 ENOG4105C1Q protoporphyrinogen oxidase F0362_05550 ENOG4105ECB domain protein F0362_05600 ENOG4106AXD F0362_05605 ENOG4108RQ5 Beta-lactamase domain-containing protein F0362_05610 ENOG4105DF9 Lipoate-protein, ligase F0362_05620 ENOG4105CEY Amp-dependent synthetase and ligase F0362_05640 ENOG4107RN3 metallophosphoesterase F0362_05650 ENOG4107TVP HD domain protein F0362_05660 ENOG4108AEY RNA polymerase sigma factor F0362_05665 ENOG41086D8 Transcriptional regulator F0362_05685 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0362_05710 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 F0362_05715 ENOG4105C8Q Methyl-accepting chemotaxis F0362_05725 ENOG4107QP3 malate synthase g F0362_05750 ENOG4105VEQ Cold shock protein F0362_05760 ENOG4105XVF Competence transcription factor F0362_05785 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation F0362_05830 ENOG4105ERH Fumarylacetoacetate hydrolase F0362_05855 ENOG4105CAQ asparagine synthetase F0362_05865 ENOG4105CH6 catalase F0362_05870 ENOG4105BZU Histidine kinase F0362_05885 ENOG4107A6P F0362_05895 ENOG4105QNR S1 RNA binding domain protein F0362_05910 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F0362_05920 ENOG4107AYK membrAne F0362_05925 ENOG41073B9 F0362_05935 ENOG4108KP7 hydrolase F0362_05945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F0362_05970 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F0362_05975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F0362_05995 ENOG4105C31 Tryptophanyl-tRNA synthetase F0362_06015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F0362_06020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F0362_06030 ENOG4108JQ7 (ABC) transporter F0362_06035 ENOG4105UQX Mate efflux family protein F0362_06055 ENOG4108ZCF integral membrane protein F0362_06065 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F0362_06075 ENOG4105DPN Oligoendopeptidase f F0362_06090 ENOG4108Z18 K06886 hemoglobin F0362_06095 ENOG4105MIX Adenylate cyclase F0362_06110 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F0362_06115 ENOG4105EMS pseudouridine synthase F0362_06135 ENOG4105K64 Glycosyl transferase, family 2 F0362_06155 ENOG4107TVC Glycosyl transferase, family 2 F0362_06175 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) F0362_06180 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase F0362_06190 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase F0362_06250 ENOG4108RNG Permease of the drug metabolite transporter F0362_06265 ENOG4105CK7 Sodium proline symporter F0362_06270 ENOG4105CRQ synthase (Component I) F0362_06275 ENOG4105DDQ anthranilate synthase F0362_06280 ENOG4108I0Q anthranilate phosphoribosyltransferase F0362_06295 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) F0362_06385 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F0362_06405 ENOG4105C7S Dehydrogenase F0362_06410 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 F0362_06415 ENOG4105VZ8 Transcriptional regulator F0362_06455 ENOG4108IUX (ABC) transporter F0362_06460 ENOG4105RHA ABC transporter, permease F0362_06560 ENOG4108NE4 F0362_06565 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F0362_06585 ENOG4105DZ1 carboxypeptidase F0362_06590 ENOG4105VFR signal peptidase F0362_06625 ENOG4105C26 Dehydrogenase F0362_06635 ENOG4105F38 ABC transporter, permease F0362_06640 ENOG4105D38 putrescine abc transporter F0362_06645 ENOG4107RUE extracellular solute-binding protein family 1 F0362_06655 ENOG4105EYF MMPL domain protein F0362_06665 ENOG4108YBP pseudouridine synthase F0362_06675 ENOG4105K4I Scp-like extracellular F0362_06680 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F0362_06685 ENOG4105CQB FAD linked oxidase domain protein F0362_06700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_06705 ENOG4105BZU Histidine kinase F0362_06710 ENOG4105JXH GntR family transcriptional regulator F0362_06730 ENOG4106A3R peptidase F0362_06740 ENOG4108QTI )-transporter F0362_06745 ENOG4107TS3 membrane protein, TerC F0362_06750 ENOG4105CZN Potassium uptake protein F0362_06755 ENOG410681C small acid-soluble spore protein F0362_06760 ENOG4108Z7G MaoC domain protein dehydratase F0362_06780 ENOG4105CHR reductase F0362_06810 ENOG4105C4Y ABC transporter F0362_06815 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0362_06820 ENOG4107RCV ABC transporter, permease F0362_06840 ENOG4105E98 transcriptional regulator DeoR family F0362_06850 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) F0362_06860 ENOG4105PXI polysaccharide deacetylase F0362_06870 ENOG4105BZU Histidine kinase F0362_06875 ENOG41090MY MarR family Transcriptional regulator F0362_06885 ENOG4106DF1 F0362_06895 ENOG4105BZU Histidine kinase F0362_06900 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) F0362_06905 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F0362_06910 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F0362_06930 ENOG4108R6G acetyltransferase F0362_06950 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) F0362_06965 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F0362_06970 ENOG4105CUB amino acid F0362_06975 ENOG4105D82 Glutamate dehydrogenase F0362_06990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0362_06995 ENOG4105C26 Dehydrogenase F0362_07000 ENOG4105C8Y Acetylornithine aminotransferase F0362_07005 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family F0362_07010 ENOG4105CZV ABC transporter F0362_07020 ENOG4105CJ1 ABC, transporter F0362_07065 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F0362_07070 ENOG4105EA8 2-Nitropropane dioxygenase F0362_07075 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD F0362_07085 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein F0362_07105 ENOG4105NQC Flavodoxin F0362_07130 ENOG4107QMU Mate efflux family protein F0362_07135 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F0362_07170 ENOG4105CZN Potassium uptake protein F0362_07175 ENOG41063Y9 F0362_07180 ENOG4105KBJ sporulation protein ytfj F0362_07205 ENOG4105CM2 brancheD-chain amino acid aminotransferase F0362_07210 ENOG4105C7K acetolactate synthase F0362_07215 ENOG4108ZP8 Acetolactate synthase small subunit F0362_07235 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F0362_07265 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F0362_07285 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase F0362_07290 ENOG4107RVV histidinol phosphate phosphatase, hisj family F0362_07300 ENOG4105C5I Dehydrogenase F0362_07305 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F0362_07310 ENOG4105E0M Sulfatase F0362_07320 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) F0362_07335 ENOG4107S4M Sulfate adenylate transferase F0362_07340 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) F0362_07345 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) F0362_07355 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F0362_07360 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein F0362_07365 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein F0362_07370 ENOG4105C8J )-transporter F0362_07390 ENOG4105DFD Na H antiporter F0362_07410 ENOG4105ENE Histidine kinase F0362_07415 ENOG4105WH1 Two component transcriptional regulator luxr family F0362_07435 ENOG41089UC methyltransferase, type 11 F0362_07460 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F0362_07480 ENOG4105CJ3 phosphate transporter F0362_07485 ENOG4107GRR phosphate transport regulator F0362_07490 ENOG4105BZ4 penicillin-binding protein F0362_07510 ENOG4105BZU Histidine kinase F0362_07515 ENOG4105I3N Conserved Protein F0362_07530 ENOG4105BZU Histidine kinase F0362_07560 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0362_07565 ENOG4105DZ1 carboxypeptidase F0362_07570 ENOG4108JIC nucleoside recognition domain protein F0362_07580 ENOG4105FE9 pseudouridine synthase F0362_07590 ENOG4107TWT Cytochrome c biogenesis protein F0362_07595 ENOG4105CRE cytochrome C F0362_07600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_07605 ENOG4105BZU Histidine kinase F0362_07610 ENOG4108WBT adenosyltransferase F0362_07615 ENOG41063SB peptidase F0362_07625 ENOG4108SAX Membrane F0362_07635 ENOG4105T7X F0362_07640 ENOG4105C9U ATP-dependent DNA helicase RecQ F0362_07645 ENOG4105I7S Abortive infection protein F0362_07655 ENOG4107RGJ metallophosphoesterase F0362_07660 ENOG4108XDN Transcriptional regulator F0362_07665 ENOG4108S6Z Negative regulator of genetic competence F0362_07690 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase F0362_07695 ENOG4105HDK L-asparaginase F0362_07710 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) F0362_07725 ENOG4105S2F F0362_07730 ENOG41065D1 F0362_07760 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) F0362_07775 ENOG4105XXQ heptaprenyl diphosphate synthase component I F0362_07785 ENOG4105EAH synthase F0362_07790 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) F0362_07810 ENOG41068YB TPR repeat-containing protein F0362_07825 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) F0362_07830 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) F0362_07865 ENOG4108JYZ YitT family F0362_07870 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase F0362_07885 ENOG4105FJR Lmbe family F0362_07890 ENOG4105CPK Glycosyl transferase (Group 1 F0362_07925 ENOG4105DVT helicase F0362_07930 ENOG4105YAC F0362_07950 ENOG4105CSM endonuclease III F0362_07960 ENOG4105BZ4 penicillin-binding protein F0362_08005 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) F0362_08015 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) F0362_08025 ENOG4105DVT helicase F0362_08030 ENOG4105CTD carboxy-peptidase F0362_08045 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F0362_08055 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) F0362_08060 ENOG4105C2W permease F0362_08065 ENOG4105DHF Membrane F0362_08075 ENOG410890F Dynamin family F0362_08085 ENOG4108W0I acetyltransferase F0362_08095 ENOG4105KHC sulfurtransferase F0362_08115 ENOG4105D7V transposase F0362_08125 ENOG4106032 Glutathionylspermidine synthase F0362_08155 ENOG4108SZE gCN5-related N-acetyltransferase F0362_08175 ENOG41081VK Ribonuclease F0362_08245 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F0362_08255 ENOG4107RWR Sodium hydrogen exchanger F0362_08260 ENOG4108Z5V transcriptional regulator, merr family F0362_08270 ENOG4105H67 Protein of unknown function (DUF421) F0362_08275 ENOG41080C8 DUF218 domain F0362_08325 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F0362_08335 ENOG4107R0U MotA TolQ exbB proton channel F0362_08340 ENOG4105ER2 Ompa motb domain protein F0362_08345 ENOG4107YTP response regulator receiver protein F0362_08350 ENOG4105CBS Chea signal transduction histidine kinase F0362_08355 ENOG4105DD5 Flagellar motor switch protein F0362_08370 ENOG4105BZU Histidine kinase F0362_08390 ENOG4105E1Q flagellar hook-associated protein F0362_08395 ENOG4105DTJ flagellar hook-associated protein F0362_08415 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) F0362_08420 ENOG4108ZC9 flagellar basal-body rod protein flgc F0362_08425 ENOG41075Z6 flagellar hook-basal body complex protein fliE F0362_08430 ENOG4107U2N Flagellar M-ring protein F0362_08435 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F0362_08465 ENOG4105BZE flagellar hook protein, FlgE F0362_08480 ENOG4107R88 Chemotaxis protein (CheV) F0362_08490 ENOG4105I03 Flagellin F0362_08495 ENOG4105I03 Flagellin F0362_08500 ENOG4105E4C Lytic transglycosylase catalytic F0362_08510 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F0362_08515 ENOG4105DD5 Flagellar motor switch protein F0362_08525 ENOG4105CN7 Flagellar biosynthetic protein FliP F0362_08530 ENOG4105VS8 Flagellar biosynthetic protein fliq F0362_08540 ENOG4105D00 flagellar biosynthetic protein flhB F0362_08545 ENOG4105D7B Flagellar biosynthesis protein flha F0362_08550 ENOG4105FZW flagellar biosynthesis regulator FlhF F0362_08555 ENOG4105KTQ flagellar basal-body rod protein F0362_08560 ENOG4105CPU Monooxygenase F0362_08595 ENOG4105KAC Antibiotic biosynthesis monooxygenase F0362_08620 ENOG4105DUM transcriptional regulator, lysR family F0362_08625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F0362_08630 ENOG4105C4Y ABC transporter F0362_08635 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component F0362_08640 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) F0362_08675 ENOG4105CVJ phosphoglycerate mutase F0362_08695 ENOG4105K56 Transcriptional regulator F0362_08705 ENOG4105CAQ asparagine synthetase F0362_08725 ENOG4105PGM cation diffusion facilitator family transporter F0362_08735 ENOG4105DRR Transcriptional regulator, GntR family F0362_08740 ENOG4108UZ3 Transporter F0362_08750 ENOG4105CKI cobalamin synthesis protein F0362_08760 ENOG4105DFD Na H antiporter F0362_08765 ENOG4105VUF Transcriptional regulator F0362_08770 ENOG4105EMU Dehydrogenase F0362_08775 ENOG4105C9Q fumarate hydratase class II F0362_08790 ENOG4107QJQ Mate efflux family protein F0362_08795 ENOG4105EC3 peptidase S51, dipeptidase E F0362_08815 ENOG4107QIV Cytochrome c biogenesis protein F0362_08820 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F0362_08840 ENOG4106BRA Membrane F0362_08880 ENOG4105CJ1 ABC, transporter F0362_08900 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F0362_08910 ENOG4108IJ0 Aspartate ammonia-lyase F0362_08915 ENOG4105C6K Malic enzyme F0362_08940 ENOG4105C0D helicase F0362_08955 ENOG41067QW Transcriptional regulator F0362_08980 ENOG4105FVX F0362_08985 ENOG4105E09 nadh pyrophosphatase F0362_09010 ENOG4105CSR polyphosphate kinase 2 F0362_09015 ENOG4105U3E Transcriptional regulator F0362_09025 ENOG4105DXI Major Facilitator superfamily F0362_09040 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F0362_09045 ENOG4105EU0 Major facilitator Superfamily F0362_09050 ENOG4105C6T cysteine synthase F0362_09070 ENOG4105C8J )-transporter F0362_09080 ENOG4105X5K response regulator receiver protein F0362_09085 ENOG4105H67 Protein of unknown function (DUF421) F0362_09105 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) F0362_09110 ENOG4105CHR reductase F0362_09115 ENOG4105CM2 brancheD-chain amino acid aminotransferase F0362_09120 ENOG4105C7K acetolactate synthase F0362_09130 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F0362_09140 ENOG4105C7B Threonine dehydratase F0362_09165 ENOG4105C6X Major Facilitator F0362_09170 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F0362_09180 ENOG4107X42 5-methylthioadenosine S-adenosylhomocysteine nucleosidase F0362_09185 ENOG4105K5X acetyltransferase F0362_09220 ENOG41068WN F0362_09240 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) F0362_09255 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) F0362_09260 ENOG4105C0X amino acid F0362_09295 ENOG4107RHR regulatoR F0362_09305 ENOG4105D9N nucleoside F0362_09310 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) F0362_09315 ENOG4105KG3 cytidine deaminase F0362_09345 ENOG410811B TRANSCRIPTIONal F0362_09360 ENOG4107RAQ aminopeptidase F0362_09365 ENOG4107R16 Multicopper oxidase F0362_09375 ENOG4105F6J Alpha beta hydrolase fold F0362_09435 ENOG4105EJQ L-serine dehydratase F0362_09440 ENOG4105C44 Serine transporter F0362_09475 ENOG4105CJZ response regulator F0362_09515 ENOG4105CNI cell division protein FtsW F0362_09520 ENOG4105CJW magnesium transporter F0362_09530 ENOG41076HS cation diffusion facilitator family transporter F0362_09555 ENOG4105F6J Alpha beta hydrolase fold F0362_09595 ENOG4105C5Q Transcriptional regulator F0362_09625 ENOG4108T5E Copper resistance protein F0362_09630 ENOG4105KTB nuclear export factor GLE1 F0362_09635 ENOG4107RT3 EamA-like transporter family F0362_09640 ENOG4105GZI Transcriptional regulator F0362_09645 ENOG4108Z40 Transcriptional regulator F0362_09650 ENOG4107ZXU DSBA oxidoreductase F0362_09655 ENOG4108TVJ Nitroreductase F0362_09660 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F0362_09665 ENOG4106F5Q Membrane F0362_09675 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F0362_09685 ENOG4105CKI cobalamin synthesis protein F0362_09695 ENOG4105C0Z ABC transporter F0362_09700 ENOG4108IV0 ABC, transporter F0362_09705 ENOG4105C32 Amino acid ABC transporter (Permease) F0362_09715 ENOG4105EGI Transcriptional regulator F0362_09745 ENOG4105C4M (Ubiquinol oxidase) subunit I F0362_09750 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F0362_09755 ENOG4108JJ9 ABC, transporter F0362_09760 ENOG4108JJ8 (ABC) transporter F0362_09765 ENOG4105K64 Glycosyl transferase, family 2 F0362_09810 ENOG4105BZ1 (ABC) transporter F0362_09815 ENOG4105EFI regulatoR F0362_09820 ENOG4105BZU Histidine kinase F0362_09830 ENOG4108VQJ O-methyltransferase F0362_09840 ENOG41075D4 Aminoglycoside 6-adenylyltransferase F0362_09845 ENOG4108ZJ4 polysaccharide deacetylase F0362_09850 ENOG4106AKJ F0362_09865 ENOG4105D6E homoserine dehydrogenase F0362_09875 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) F0362_09890 ENOG4108KGH TRANSCRIPTIONal F0362_09900 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0362_09905 ENOG4105BZU Histidine kinase F0362_09910 ENOG4107VMI polysaccharide deacetylase F0362_09920 ENOG4105KT7 mgtC SapB transporter F0362_09925 ENOG4105VRR gCN5-related N-acetyltransferase F0362_09935 ENOG4105DUU IucA IucC family protein F0362_09940 ENOG4105CEY Amp-dependent synthetase and ligase F0362_09955 ENOG4108WBH protein TIM barrel F0362_09960 ENOG4105YWU small acid-soluble spore protein F0362_09970 ENOG4108ZUB Lysine exporter protein (Lyse ygga) F0362_09975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0362_10025 ENOG4105KRN Transcriptional regulator, abrb family F0362_10035 ENOG4105YVS arsR family transcriptional regulator F0362_10040 ENOG4105CPC Aldo Keto reductase F0362_10085 ENOG4108K88 Membrane F0362_10090 ENOG4108WPJ Ferritin-like domain F0362_10105 ENOG4105DEN Luciferase family F0362_10125 ENOG4105VMI -acetyltransferase F0362_10130 ENOG4107QM2 Aldo Keto reductase F0362_10135 ENOG4105CKI cobalamin synthesis protein F0362_10145 ENOG4105DSE periplasmic solute binding protein F0362_10150 ENOG4105K4T epimerase F0362_10160 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F0362_10170 ENOG4108J59 Extracellular solute-binding protein, family 5 F0362_10185 ENOG4107TB6 phosphoglycerate mutase F0362_10205 ENOG4107T5V SNARE associated Golgi F0362_10220 ENOG4108PJD permease F0362_10230 ENOG4108S4H thioesterase Superfamily protein F0362_10240 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F0362_10260 ENOG4105SXS Protein of unknown function (DUF456) F0362_10265 ENOG4105C37 (CBS) domain F0362_10285 ENOG4108Z7R Chaperone CsaA F0362_10305 ENOG4108ZRV stage ii sporulation protein p F0362_10320 ENOG4108VXD carboxy-peptidase F0362_10350 ENOG4108ZRV stage ii sporulation protein p F0362_10360 ENOG4108X4Q Hydrolase F0362_10365 ENOG41082F9 transcriptional regulator F0362_10370 ENOG4105D94 Major Facilitator Superfamily F0362_10380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F0362_10395 ENOG41087PP glycosyltransferase MGT family F0362_10400 ENOG4108JYZ YitT family F0362_10405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0362_10430 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) F0362_10450 ENOG4106PAW secretion accessory protein EsaA YueB F0362_10460 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) F0362_10535 ENOG4105KBJ sporulation protein ytfj F0362_10565 ENOG4108KQJ Type 11 methyltransferase F0362_10585 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily F0362_10595 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F0362_10600 ENOG4105EMN RNA polymerase sigma factor F0362_10620 ENOG4105CNW domain protein F0362_10630 ENOG4108V06 Glutathione peroxidase F0362_10645 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F0362_10655 ENOG4108IUE nitrate reductase beta subunit F0362_10660 ENOG4105R3A Nitrate reductase F0362_10670 ENOG4107V6Q Cyclic nucleotide-binding domain F0362_10675 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F0362_10680 ENOG4105D06 uba thif-type nad fad binding protein F0362_10685 ENOG4105CVM Molybdenum cofactor synthesis domain protein F0362_10690 ENOG4108ZAF Molybdopterin F0362_10715 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein F0362_10720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F0362_10725 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit F0362_10730 ENOG4108IFG nitrite reductase, (NAD(P)H) F0362_10735 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) F0362_10775 ENOG4105D9U N-acetyltransferase F0362_10780 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F0362_10820 ENOG4105MCT stage V sporulation protein S F0362_10835 ENOG4105C5H ABC transporter F0362_10850 ENOG4108UUM single-stranded DNA-binding protein F0362_10880 ENOG4107YX5 Pfam:DUF548 F0362_10885 ENOG4105C75 arginyL-tRNA synthetase F0362_10900 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F0362_10915 ENOG4105C5S asparaginyl-tRNA synthetase F0362_10920 ENOG4105C8J )-transporter F0362_10940 ENOG4107XGZ Hydrolase F0362_10945 ENOG4105CY2 Citrate transporter F0362_10965 ENOG4105KD7 acetyltransferase F0362_10970 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase F0362_10985 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 F0362_11000 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) F0362_11015 ENOG4107RVG penicillin-binding protein F0362_11025 ENOG4105E9Q Acyl-transferase F0362_11030 ENOG4108UT2 hemolysin iii F0362_11040 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F0362_11050 ENOG4108RCR degv family F0362_11055 ENOG4105E8R UPF0173 metal-dependent hydrolase F0362_11060 ENOG4108KF3 Electron transport protein SCO1 SenC F0362_11065 ENOG4107Y70 Heat shock protein F0362_11070 ENOG4105CAQ asparagine synthetase F0362_11085 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F0362_11090 ENOG4108MES Periplasmic binding protein F0362_11095 ENOG4105F0I Aminotransferase F0362_11125 ENOG4105D8X mechanosensitive ion channel F0362_11130 ENOG4105BZU Histidine kinase F0362_11135 ENOG4105WH1 Two component transcriptional regulator luxr family F0362_11140 ENOG4106KNT transcriptional regulator F0362_11170 ENOG4105CMG Carbohydrate kinase F0362_11175 ENOG4105C6Z Gluconate F0362_11185 ENOG4108YV3 Protein of unknown function (DUF2711) F0362_11215 ENOG4108IJ8 ABC transporter F0362_11220 ENOG4105E90 ABC transporter F0362_11255 ENOG4105C37 (CBS) domain F0362_11280 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F0362_11295 ENOG4107S4Y M20 DapE family protein YgeY F0362_11300 ENOG4108TSC N-acetyltransferase F0362_11305 ENOG4108JUB Transcriptional regulator F0362_11310 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F0362_11355 ENOG410841Q phosphoesterase PA-phosphatase related protein F0362_11365 ENOG4105SZ6 Thioredoxin F0362_11415 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F0362_11440 ENOG4105CHR reductase F0362_11460 ENOG4105BZ4 penicillin-binding protein F0362_11470 ENOG4105CZM Major Facilitator F0362_11485 ENOG4105DXD 2-methylcitrate dehydratase F0362_11490 ENOG4105CR4 methylisocitrate lyase F0362_11495 ENOG4105C1G acyl-Coa dehydrogenase F0362_11500 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F0362_11510 ENOG4105N14 lysine exporter protein LysE YggA F0362_11515 ENOG4105E39 Enoyl-CoA hydratase F0362_11530 ENOG4107RFY SbcCD D subunit F0362_11555 ENOG4105FCD Major Facilitator F0362_11560 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F0362_11565 ENOG4105E4F Isochorismate synthase F0362_11570 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F0362_11575 ENOG4105WQI isochorismatase F0362_11580 ENOG4105CEY Amp-dependent synthetase and ligase F0362_11585 ENOG4105WQT MbtH domain protein F0362_11590 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0362_11605 ENOG4105K70 DNA-binding protein F0362_11640 ENOG4105BZG amino acid carrier protein F0362_11660 ENOG4105FE9 pseudouridine synthase F0362_11665 ENOG4105C22 threonyL-tRNA synthetase F0362_11670 ENOG4105C19 ABC transporter F0362_11680 ENOG4107SKW Inherit from COG: Alpha beta hydrolase F0362_11705 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) F0362_11720 ENOG41081I9 integral membrane protein F0362_11730 ENOG4108Y4K DNA-binding transcriptional activator F0362_11740 ENOG41075H3 AraC family transcriptional regulator F0362_11765 ENOG4105EXC Acyl-transferase F0362_11780 ENOG4105BZU Histidine kinase F0362_11790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_11810 ENOG4107MII Sugar-specific transcriptional regulator TrmB F0362_11820 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F0362_11825 ENOG41067SE Tetr family transcriptional regulator F0362_11830 ENOG4105EYF MMPL domain protein F0362_11850 ENOG4105WCN acetyltransferase F0362_11875 ENOG4105C1Q protoporphyrinogen oxidase F0362_11885 ENOG41068WN F0362_11915 ENOG4107V2S Transcriptional regulator F0362_11920 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F0362_11925 ENOG4105DND Transcriptional regulator F0362_11930 ENOG4108JPW Aminotransferase F0362_11935 ENOG4108RPX mosc domain containing protein F0362_11950 ENOG4105BZ1 (ABC) transporter F0362_11955 ENOG4105BZ1 (ABC) transporter F0362_11965 ENOG4108VP3 Lysine exporter protein (LysE YggA) F0362_11970 ENOG4108JCI Transcriptional regulator F0362_12025 ENOG4108KPJ rna polymerase sigma factor F0362_12045 ENOG4105F32 YngK protein F0362_12065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) F0362_12070 ENOG4105RD7 BadF BadG BcrA BcrD F0362_12075 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) F0362_12080 ENOG4107STF Involved in phosphonate degradation (By similarity) F0362_12105 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F0362_12120 ENOG4105C1J atp-dependent rna helicase F0362_12135 ENOG4108I0C methyltransferase F0362_12140 ENOG4107RA9 decarboxylase F0362_12150 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F0362_12175 ENOG4105CIN aminoacyl-histidine dipeptidase F0362_12205 ENOG4105KRN Transcriptional regulator, abrb family F0362_12215 ENOG4105EJ9 Membrane F0362_12220 ENOG4105EQK -acetyltransferase F0362_12245 ENOG4107RVG penicillin-binding protein F0362_12260 ENOG4107RF6 penicillin-binding protein F0362_12265 ENOG4107RF6 penicillin-binding protein F0362_12325 ENOG4108M1A Chitin-binding protein F0362_12330 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C F0362_12355 ENOG4105CJ1 ABC, transporter F0362_12365 ENOG4107Z3H Transcriptional regulator, TetR family F0362_12375 ENOG4105C1G acyl-Coa dehydrogenase F0362_12380 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F0362_12385 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit F0362_12390 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase F0362_12395 ENOG4105E39 Enoyl-CoA hydratase F0362_12400 ENOG4107QX3 carboxylase F0362_12405 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F0362_12485 ENOG4105T9C HD domain F0362_12495 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F0362_12520 ENOG41075H3 AraC family transcriptional regulator F0362_12555 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F0362_12565 ENOG4107EXU Short-chain dehydrogenase reductase Sdr F0362_12570 ENOG4105KVH Transcriptional regulator F0362_12575 ENOG41089UC methyltransferase, type 11 F0362_12585 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) F0362_12595 ENOG4105MDS 4-oxalocrotonate tautomerase F0362_12600 ENOG4105CR8 Transcriptional regulator F0362_12610 ENOG4105CUV Homoserine Kinase F0362_12625 ENOG4105SX7 Transporter F0362_12655 ENOG410900G Protein of unknown function (DUF421) F0362_12665 ENOG4108V4B ThiJ pfpI F0362_12675 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein F0362_12685 ENOG4105DK7 lysyl-tRNA synthetase F0362_12715 ENOG4106NZI LysR family Transcriptional regulator F0362_12720 ENOG4105CPC Aldo Keto reductase F0362_12760 ENOG4105D6E homoserine dehydrogenase F0362_12775 ENOG4105ETU transcriptional activator (TenA F0362_13030 ENOG410667J hydrolase F0362_13035 ENOG4105BZU Histidine kinase F0362_13040 ENOG4107RF6 penicillin-binding protein F0362_13065 ENOG4108JJB ABC transporter F0362_13080 ENOG4108HGU Histidine kinase F0362_13095 ENOG4105CB2 alcohol dehydrogenase F0362_13100 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F0362_13105 ENOG4105CJN penicillin-binding protein F0362_13160 ENOG4107TXC Transcriptional regulator F0362_13170 ENOG4107SFI Major Facilitator superfamily F0362_13185 ENOG4107VXM glycerophosphoryl diester phosphodiesterase F0362_13210 ENOG4107Y9U Membrane F0362_13245 ENOG4105FCD Major Facilitator F0362_13255 ENOG4105E09 nadh pyrophosphatase F0362_13260 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F0362_13285 ENOG4108XI2 Domain of unknown function (DUF1963) F0362_13305 ENOG4108NRW Phospholipase, patatin family F0362_13310 ENOG4105KWG Pfam:DUF1696 F0362_13320 ENOG4108YYS metal-dependent hydrolase (By similarity) F0362_13345 ENOG4105PKS Excinuclease abc c subunit domain protein F0362_13370 ENOG4107VFR oxidoreductase F0362_13400 ENOG4105U0R haloacid dehalogenase-like hydrolase F0362_13405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_13410 ENOG4105BZU Histidine kinase F0362_13460 ENOG4107WD8 ABC transporter, permease F0362_13485 ENOG4105DY8 decarboxylase F0362_13505 ENOG4108IUM Glycogen debranching enzyme F0362_13515 ENOG4105CGH 5'-nucleotidase F0362_13525 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F0362_13530 ENOG4105FDR Membrane F0362_13535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F0362_13585 ENOG4105MSI germination protein ypeb F0362_13630 ENOG4107Z3H Transcriptional regulator, TetR family F0362_13640 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family F0362_13655 ENOG4105E98 transcriptional regulator DeoR family F0362_13680 ENOG4107QKR Dehydrogenase F0362_13690 ENOG4107RUY (E1 component), alpha subunit F0362_13700 ENOG4105E1F short-chain dehydrogenase reductase F0362_13730 ENOG4107SQ8 Glycine betaine F0362_13735 ENOG4108IJ7 Glycine betaine F0362_13745 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F0362_13765 ENOG41082BV acetyltransferase F0362_13780 ENOG4108M1A Chitin-binding protein F0362_13790 ENOG41087PP glycosyltransferase MGT family F0362_13800 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) F0362_13815 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F0362_13820 ENOG4105MSB protein, conserved in bacteria F0362_13845 ENOG4108Z7F N-acetyltransferase F0362_13870 ENOG4105EEM helicase F0362_13880 ENOG4105C9U ATP-dependent DNA helicase RecQ F0362_13920 ENOG4108M1A Chitin-binding protein F0362_13940 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F0362_13950 ENOG4105BZG amino acid carrier protein F0362_13955 ENOG4105C26 Dehydrogenase F0362_13960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F0362_13965 ENOG4105CTU Proline racemase F0362_13970 ENOG4105CTU Proline racemase F0362_13975 ENOG41080HI glycine oxidase F0362_13985 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein F0362_14025 ENOG4105DCI Phosphohydrolase F0362_14030 ENOG4107T5V SNARE associated Golgi F0362_14045 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD F0362_14060 ENOG4105DTQ mandelate racemase muconate lactonizing F0362_14110 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) F0362_14115 ENOG4105BZU Histidine kinase F0362_14120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_14140 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 F0362_14145 ENOG4105DPN Oligoendopeptidase f F0362_14150 ENOG4105KEG ribosomal-protein-alanine acetyltransferase F0362_14155 ENOG4105EPR degv family F0362_14225 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) F0362_14230 ENOG4106K7D Major facilitator family transporter F0362_14255 ENOG4107BMA Transglycosylase associated protein F0362_14270 ENOG41089UC methyltransferase, type 11 F0362_14305 ENOG4105CHM Aminotransferase F0362_14320 ENOG4108ZMI UPF0477 protein F0362_14335 ENOG4105DVE abc transporter atp-binding protein F0362_14380 ENOG4105C02 permease F0362_14390 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F0362_14395 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F0362_14400 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein F0362_14405 ENOG4105D7T ABC transporter F0362_14430 ENOG4108AQF aminoglycoside N(3)-acetyltransferase F0362_14495 ENOG4105C6T cysteine synthase F0362_14500 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_14515 ENOG4107VMI polysaccharide deacetylase F0362_14530 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0362_14535 ENOG4108ZCF integral membrane protein F0362_14545 ENOG4105C5H ABC transporter F0362_14550 ENOG4105EYF MMPL domain protein F0362_14555 ENOG41082JN Transcriptional regulator F0362_14560 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F0362_14590 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F0362_14635 ENOG41069ER domain protein F0362_14645 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_14650 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F0362_14655 ENOG4108YYH Nadph-dependent fmn reductase F0362_14675 ENOG4105D4B ABC, transporter F0362_14680 ENOG4105F5R ABC transporter F0362_14685 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane F0362_14695 ENOG4105DKT Transcriptional regulator F0362_14700 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) F0362_14710 ENOG41061GT Aldolase F0362_14730 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) F0362_14750 ENOG4107QK4 glycoside hydrolase, family 3 domain protein F0362_14755 ENOG41075H3 AraC family transcriptional regulator F0362_14765 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) F0362_14770 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) F0362_14775 ENOG4105II7 pyrroline-5-carboxylate reductase F0362_14785 ENOG4107258 Transcriptional regulator F0362_14805 ENOG4105ECK Fatty Acid Desaturase F0362_14815 ENOG4105G6Z alkaline phosphatase F0362_14825 ENOG4105VMP Transcriptional regulator F0362_14855 ENOG41068WN F0362_14885 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F0362_14955 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F0362_14975 ENOG4108IBT Inherit from COG: transposase F0362_14995 ENOG4108TVJ Nitroreductase F0362_15000 ENOG4105FS7 Transcriptional regulator F0362_15025 ENOG4105WEC Molybdate metabolism regulator F0362_15055 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) F0362_15060 ENOG4108XET gCN5-related N-acetyltransferase F0362_15085 ENOG4107XJU UPF0178 protein F0362_15135 ENOG410635A Membrane F0362_15145 ENOG4108IQI permease F0362_15155 ENOG4105F1N DNA alkylation repair F0362_15190 ENOG4107RF6 penicillin-binding protein F0362_15195 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) F0362_15215 ENOG4105E7W lamb ycsf family protein F0362_15225 ENOG4105P4J Allophanate hydrolase, subunit 1 F0362_15230 ENOG4107258 Transcriptional regulator F0362_15250 ENOG4106N3A copper homeostasis protein cutc F0362_15260 ENOG4105FDT acyl-CoA dehydrogenase F0362_15275 ENOG4105DWD nucleoside recognition domain protein F0362_15325 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) F0362_15340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F0362_15355 ENOG4105CGH 5'-nucleotidase F0362_15370 ENOG4105CHJ isochorismatase hydrolase F0362_15395 ENOG41090MY MarR family Transcriptional regulator F0362_15435 ENOG4108606 TspO/MBR family F0362_15440 ENOG4105CVP deoxyribo-dipyrimidine photolyase F0362_15455 ENOG4108TWJ NADH dehydrogenase subunit 5 F0362_15460 ENOG4105GPN Uncharacterized conserved protein (DUF2294) F0362_15470 ENOG4108U7W acetyltransferase F0362_15475 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F0362_15480 ENOG4105DSE periplasmic solute binding protein F0362_15485 ENOG4105CC5 ABC transporter F0362_15490 ENOG4105DIK (ABC) transporter F0362_15505 ENOG4108KF3 Electron transport protein SCO1 SenC F0362_15510 ENOG4107ZQN disulfide bond F0362_15545 ENOG4105D6J arsenicaL-resistance protein F0362_15550 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_15555 ENOG41085FC arsR family transcriptional regulator F0362_15570 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) F0362_15580 ENOG4107P5I polyketide synthase F0362_15585 ENOG4108IG5 Transcriptional regulator F0362_15590 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) F0362_15610 ENOG4105E1K spore germination protein F0362_15620 ENOG4105CHR reductase F0362_15625 ENOG4108YXU transcriptional regulator AsnC family F0362_15660 ENOG4105N0V mono-oxygenase ydhR F0362_15710 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F0362_15715 ENOG4107ZY0 Phenazine biosynthesis-like protein F0362_15720 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0362_15725 ENOG4105K6H D-cysteine desulfhydrase F0362_15740 ENOG4105JQZ Methyltransferase F0362_15760 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) F0362_15780 ENOG4105BZU Histidine kinase F0362_15790 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) F0362_15805 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F0362_15825 ENOG4108JQ1 Dehydrogenase F0362_15965 ENOG4108VXD carboxy-peptidase F0362_15970 ENOG4105PNM synthesis protein F0362_15985 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F0362_16000 ENOG4105C3S Mate efflux family protein F0362_16005 ENOG4105C26 Dehydrogenase F0362_16010 ENOG4105MWK D-amino acid dehydrogenase, small subunit F0362_16025 ENOG4108ISG Major Facilitator F0362_16040 ENOG4107MII Sugar-specific transcriptional regulator TrmB F0362_16045 ENOG4105CZM Major Facilitator F0362_16075 ENOG4105CRW Short chain fatty acid transporter F0362_16085 ENOG4105DYS nad(p)h dehydrogenase (quinone) F0362_16145 ENOG4108K8S endonuclease I F0362_16155 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F0362_16160 ENOG4108Z66 YbaK ebsC protein F0362_16180 ENOG4105KVH Transcriptional regulator F0362_16185 ENOG4108RCM Nitroreductase F0362_16220 ENOG4108PSK reductase F0362_16290 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_16295 ENOG4105DKQ ROK family F0362_16305 ENOG4108UW5 maltose o-acetyltransferase F0362_16310 ENOG4105C31 Tryptophanyl-tRNA synthetase F0362_16345 ENOG4105EV4 Multidrug resistance protein mdtH F0362_16375 ENOG4105C37 (CBS) domain F0362_16390 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase F0362_16395 ENOG4105FAW cDP-glucose 4,6-dehydratase F0362_16420 ENOG4105DDN Pentapeptide repeat-containing protein F0362_16425 ENOG4105XDF Protein of unknown function (DUF1272) F0362_16430 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) F0362_16435 ENOG4105CMG Carbohydrate kinase F0362_16440 ENOG4105C6Z Gluconate F0362_16460 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F0362_16490 ENOG41090KN UPF0303 protein F0362_16505 ENOG4105C44 Serine transporter F0362_16510 ENOG4105VMP Transcriptional regulator F0362_16545 ENOG4105KVH Transcriptional regulator F0362_16550 ENOG4108TZY GntR Family Transcriptional Regulator F0362_16555 ENOG4105D9R oxidoreductase F0362_16610 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F0362_16615 ENOG4105KVH Transcriptional regulator F0362_16635 ENOG4108ZJ4 polysaccharide deacetylase F0362_16710 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) F0362_16720 ENOG4107YXZ hydrolase, family 25 F0362_16755 ENOG4105H3G oxidoreductase F0362_16790 ENOG4105CIS alcohol dehydrogenase F0362_16855 ENOG4108TN2 lmbE family F0362_16865 ENOG4107R3E Citrate transporter F0362_16875 ENOG4105WCN acetyltransferase F0362_16880 ENOG4108MES Periplasmic binding protein F0362_16885 ENOG4105EHG Permease protein F0362_16890 ENOG4105DQ5 transport system permease protein F0362_16895 ENOG4105NX3 Membrane F0362_16915 ENOG4107CUJ Protein of unknown function (DUF2690) F0362_16925 ENOG4107V2S Transcriptional regulator F0362_16945 ENOG4105C98 muts2 protein F0362_16950 ENOG4105E5K Alpha-amylase F0362_16955 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase F0362_16960 ENOG4105DPN Oligoendopeptidase f F0362_16990 ENOG4105FFC UPF0187 protein F0362_17005 ENOG4108A04 Beta-lactamase F0362_17020 ENOG4105EGI Transcriptional regulator F0362_17030 ENOG4107VXM glycerophosphoryl diester phosphodiesterase F0362_17040 ENOG41082BM Transcriptional regulator, arsr family F0362_17045 ENOG4105CIS alcohol dehydrogenase F0362_17085 ENOG4105CQB FAD linked oxidase domain protein F0362_17100 ENOG4105VRS hydrolase family 18 F0362_17110 ENOG4105BZU Histidine kinase F0362_17125 ENOG4108VXD carboxy-peptidase F0362_17155 ENOG4105BZU Histidine kinase F0362_17165 ENOG4105KT7 mgtC SapB transporter F0362_17175 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_17180 ENOG41073R8 VanW family F0362_17190 ENOG4108R1P F0362_17205 ENOG4105VEQ Cold shock protein F0362_17245 ENOG410904N short-chain dehydrogenase reductase F0362_17255 ENOG4106IQC argininosuccinate lyase F0362_17270 ENOG4108IA2 Sodium pantothenate symporter F0362_17280 ENOG4105C26 Dehydrogenase F0362_17285 ENOG4105CHR reductase F0362_17295 ENOG4105EWU Squalene--hopene cyclase F0362_17305 ENOG4105FR1 rard protein F0362_17310 ENOG410696E Membrane F0362_17325 ENOG4105D1F ATP-binding protein F0362_17335 ENOG4108ZAF Molybdopterin F0362_17340 ENOG4105CVM Molybdenum cofactor synthesis domain protein F0362_17345 ENOG4105D06 uba thif-type nad fad binding protein F0362_17350 ENOG4105TMB Formate nitrite transporter F0362_17360 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F0362_17365 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) F0362_17375 ENOG4108JB9 formate dehydrogenase F0362_17385 ENOG4108NHD germination protein F0362_17390 ENOG4105CUB amino acid F0362_17445 ENOG4107QJT sodium dicarboxylate symporter F0362_17450 ENOG4108KGH TRANSCRIPTIONal F0362_17460 ENOG4105EMN RNA polymerase sigma factor F0362_17470 ENOG4105CIG ABC transporter F0362_17480 ENOG4105D9R oxidoreductase F0362_17490 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F0362_17495 ENOG4105K4P CoA-binding domain protein F0362_17500 ENOG4105C0H protease F0362_17505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_17510 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) F0362_17515 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase F0362_17520 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) F0362_17525 ENOG4105W8X HesB YadR YfhF-family protein F0362_17550 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) F0362_17555 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F0362_17570 ENOG4108I0Z Aconitate hydratase F0362_17600 ENOG4105E5W Transporter F0362_17610 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F0362_17630 ENOG4107F3J Amp-dependent synthetase and ligase F0362_17635 ENOG4107ZYJ bioY protein F0362_17640 ENOG4105CEY Amp-dependent synthetase and ligase F0362_17645 ENOG4108IMY Transcriptional regulator F0362_17685 ENOG4107AYK membrAne F0362_17695 ENOG4105BZU Histidine kinase F0362_17700 ENOG4105FBA Phospholipase Carboxylesterase F0362_17705 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase F0362_17710 ENOG4105CBC glutamate synthase F0362_17715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F0362_17720 ENOG4108VJ1 Transcriptional regulator (CarD family F0362_17725 ENOG4108903 Formimidoylglutamase F0362_17750 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F0362_17785 ENOG4107QIV Cytochrome c biogenesis protein F0362_17800 ENOG4105CH2 amidohydrolase F0362_17810 ENOG4105CJ1 ABC, transporter F0362_17825 ENOG4107RSM transcriptional regulator F0362_17835 ENOG41067MG lrgb family F0362_17875 ENOG4105BZ1 (ABC) transporter F0362_17880 ENOG4105BZ1 (ABC) transporter F0362_17920 ENOG4105CGH 5'-nucleotidase F0362_17930 ENOG4108SVB resolvase F0362_17950 ENOG4105K7K Transcriptional regulator F0362_17955 ENOG4105BZ1 (ABC) transporter F0362_17985 ENOG4105CAQ asparagine synthetase F0362_17990 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F0362_18000 ENOG4105CPF Cell wall formation (By similarity) F0362_18005 ENOG4105D3Q Sugar transferase F0362_18035 ENOG4108KMV Glycosyl transferase (Group 1 F0362_18040 ENOG41068W6 Capsular polysaccharide biosynthesis protein F0362_18045 ENOG4107SJB teichoic acid biosynthesis F0362_18050 ENOG4108KMV Glycosyl transferase (Group 1 F0362_18055 ENOG4108PQP glycosyl transferase group 1 F0362_18065 ENOG4107YJ4 chain length determinant protein F0362_18085 ENOG4105E4C Lytic transglycosylase catalytic F0362_18090 ENOG41065S2 pneumococcal vaccine antigen F0362_18125 ENOG4105C5F glutamine synthetase F0362_18130 ENOG4105KV4 Transcriptional regulator F0362_18135 ENOG4105CXI aluminum resistance protein F0362_18140 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F0362_18145 ENOG4105EN6 Membrane F0362_18150 ENOG4106F1P AAA ATPase, central domain protein F0362_18180 ENOG41069ER domain protein F0362_18185 ENOG4105DM4 PTS System F0362_18190 ENOG4105DE4 1-phosphofructokinase F0362_18195 ENOG4105E98 transcriptional regulator DeoR family F0362_18200 ENOG4107QW4 alcohol dehydrogenase F0362_18205 ENOG4108SJC Membrane F0362_18215 ENOG4105C85 amino acid F0362_18255 ENOG4105C59 p-type ATPase F0362_18260 ENOG410681U heavy metal transport detoxification protein F0362_18265 ENOG4105VPX protein, conserved in bacteria F0362_18285 ENOG4105NIV Esterase F0362_18290 ENOG4105E0A ABC, transporter F0362_18310 ENOG4105CGK Exodeoxyribonuclease III F0362_18320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F0362_18325 ENOG4105D03 DNA-3-methyladenine glycosylase II F0362_18355 ENOG4105BZU Histidine kinase F0362_18375 ENOG4105C5E polysaccharide biosynthesis protein F0362_18395 ENOG41067MG lrgb family F0362_18410 ENOG4107TTQ Alpha beta hydrolase fold F0362_18415 ENOG4107YEI lmbE family F0362_18440 ENOG4105F0V Cell wall hydrolase F0362_18450 ENOG4105E0M Sulfatase F0362_18465 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) F0362_18490 ENOG4105DQU oxidoreductase, subunit beta F0362_18495 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein F0362_18500 ENOG4108IGT Dipeptidase F0362_18505 ENOG4105MCT stage V sporulation protein S F0362_18510 ENOG4105D48 metallophosphoesterase F0362_18540 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase F0362_18555 ENOG4105XZV Protein of unknown function (DUF3243) F0362_18560 ENOG4108RKS Short-chain dehydrogenase reductase Sdr F0362_18580 ENOG4105UIB (ABC) transporter F0362_18585 ENOG4108JQ9 ABC transporter F0362_18590 ENOG4105DIH basic membrane F0362_18595 ENOG4105FDP GntR family transcriptional regulator F0362_18605 ENOG4107QZI cell division protein FtsK F0362_18615 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit F0362_18625 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F0362_18635 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F0362_18640 ENOG4108S0H Dipicolinic acid synthetase, b subunit F0362_18645 ENOG4105E35 Dipicolinate synthase subunit A F0362_18655 ENOG4105C1V Peptidase, M16 F0362_18675 ENOG4105DTN riboflavin biosynthesis protein ribF F0362_18690 ENOG4105W7A Protein of unknown function (DUF503) F0362_18700 ENOG4105VHM ribosomal protein F0362_18705 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination F0362_18710 ENOG4105CHV Transcription elongation factor NusA F0362_18720 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) F0362_18730 ENOG4105DZP Membrane-associated zinc metalloprotease F0362_18740 ENOG4105KNE Phosphatidate cytidylyltransferase F0362_18745 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F0362_18760 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) F0362_18785 ENOG4108HE4 integrase family F0362_18795 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F0362_18800 ENOG4105C79 DNA protecting protein DprA F0362_18805 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F0362_18820 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) F0362_18845 ENOG4105VB6 UPF0109 protein F0362_18865 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F0362_18870 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) F0362_18885 ENOG4105CHR reductase F0362_18890 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F0362_18905 ENOG4105CB5 ATP-dependent DNA helicase recG F0362_18910 ENOG4105DP4 dak2 domain fusion protein ylov F0362_18915 ENOG4108ZAA Alkaline-shock protein F0362_18930 ENOG4105FJ0 thiamine F0362_18935 ENOG4105DJV ribulose-phosphate 3-epimerase F0362_18940 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F0362_18945 ENOG4105D9P serine threonine protein kinase F0362_18950 ENOG4108ZF3 Phosphatase F0362_18960 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F0362_18965 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F0362_18975 ENOG4105C25 Primosomal protein n' F0362_18980 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F0362_19000 ENOG4105DSJ YicC domain protein F0362_19010 ENOG4105F23 Fibronectin-binding protein F0362_19015 ENOG4105DC7 peptidase M24 F0362_19060 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) F0362_19095 ENOG4105C34 Pseudouridine synthase F0362_19120 ENOG4105DBK s4 domain protein F0362_19125 ENOG41067XK integral membrane protein F0362_19135 ENOG4105DFA alanine racemase domain protein F0362_19140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F0362_19145 ENOG4105WR5 sporulation protein, YlmC YmxH family F0362_19155 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0362_19165 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F0362_19170 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F0362_19175 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) F0362_19190 ENOG4105CNI cell division protein FtsW F0362_19205 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F0362_19210 ENOG4105CJN penicillin-binding protein F0362_19215 ENOG4105CJN penicillin-binding protein F0362_19255 ENOG4105KNH Nucleic acid-binding protein F0362_19265 ENOG41063PX domain protein F0362_19270 ENOG4105D78 K07001 NTE family protein F0362_19275 ENOG4105H20 Sporulation integral membrane protein YlbJ F0362_19285 ENOG4106H78 methyltransferase F0362_19305 ENOG4107TB6 phosphoglycerate mutase F0362_19320 ENOG4106UY4 Inherit from COG: Scp-like extracellular F0362_19370 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) F0362_19380 ENOG4105CNI cell division protein FtsW F0362_19395 ENOG4108IAB Phoh family F0362_19415 ENOG4105QA2 F0362_19420 ENOG4105CI3 gtp-binding protein typa F0362_19430 ENOG4105ECY inositol monophosphatase F0362_19450 ENOG4105CXN decarboxylase F0362_19490 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein F0362_19510 ENOG4105CPP Dehydrogenase, E1 component F0362_19525 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F0362_19530 ENOG4108X4Q Hydrolase F0362_19545 ENOG4105CN5 Metallo-Beta-Lactamase F0362_19550 ENOG4107ZYR domain protein F0362_19565 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) F0362_19585 ENOG4108XRC Protein of unknown function (DUF458) F0362_19590 ENOG4107IN1 Protein of unknown function (DUF1797) F0362_19605 ENOG4105EPM Diguanylate phosphodiesterase F0362_19610 ENOG4105K6S Short-chain dehydrogenase reductase Sdr F0362_19625 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F0362_19635 ENOG4105UIN F0362_19690 ENOG4108HGU Histidine kinase F0362_19700 ENOG4105CHM Aminotransferase F0362_19705 ENOG4105FKQ transcriptional regulator F0362_19710 ENOG4105EG2 ABC transporter, permease F0362_19720 ENOG4107FKK extracellular solute-binding protein family 1 F0362_19730 ENOG4105CG3 alpha amylase, catalytic region F0362_19780 ENOG4105CHU acetyl-coa acetyltransferase F0362_19815 ENOG4105K7K Transcriptional regulator F0362_19820 ENOG4105DTD Dehydrogenase F0362_19840 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F0362_19865 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) F0362_19880 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F0362_19890 ENOG4105BZU Histidine kinase F0362_19910 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F0362_19925 ENOG4105CID antiterminator F0362_19935 ENOG4105FDP GntR family transcriptional regulator F0362_19945 ENOG4105CE4 GlcNAc 6-P deacetylase F0362_19985 ENOG4107ZE5 PPIases accelerate the folding of proteins F0362_19990 ENOG4105PTM secreted protein F0362_19995 ENOG4105J7I hydrolase F0362_20005 ENOG4105G6R Stage v sporulation protein ae F0362_20015 ENOG4105CZ3 stage V sporulation protein ad F0362_20020 ENOG41090VF Stage v sporulation protein ac F0362_20040 ENOG4105C8J )-transporter F0362_20045 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0362_20055 ENOG41082AN stage II sporulation protein F0362_20060 ENOG4105DZ1 carboxypeptidase F0362_20070 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family F0362_20075 ENOG4105DVE abc transporter atp-binding protein F0362_20115 ENOG4105D7N magnesium and cobalt transport protein CorA F0362_20140 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F0362_20150 ENOG4105I3K Ferric uptake regulator, Fur family F0362_20155 ENOG4105MZ9 stage II sporulation protein m F0362_20175 ENOG4105CPC Aldo Keto reductase F0362_20180 ENOG4105CV8 reductase F0362_20185 ENOG4105RHY Pfam:UPF0157 F0362_20205 ENOG4107SKW Inherit from COG: Alpha beta hydrolase F0362_20215 ENOG4105ETE Transcriptional regulator (LacI family F0362_20220 ENOG4108YM7 Gcn5-related n-acetyltransferase F0362_20245 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F0362_20250 ENOG4108R6K riboflavin synthase, subunit alpha F0362_20275 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F0362_20280 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F0362_20295 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F0362_20305 ENOG4105DFD Na H antiporter F0362_20310 ENOG4105CGH 5'-nucleotidase F0362_20355 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase F0362_20365 ENOG4108IXY short-chain dehydrogenase reductase F0362_20370 ENOG41069FQ Metallo-beta-lactamase superfamily F0362_20375 ENOG4105II7 pyrroline-5-carboxylate reductase F0362_20380 ENOG4105EJQ L-serine dehydratase F0362_20405 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic F0362_20415 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F0362_20425 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F0362_20430 ENOG4105D9U N-acetyltransferase F0362_20445 ENOG4108VZI ErfK ybiS ycfS ynhG family protein F0362_20450 ENOG4108QEG Membrane F0362_20455 ENOG4105CDA abc transporter atp-binding protein F0362_20460 ENOG4105E5Q amino acid AbC transporter F0362_20465 ENOG4108HW3 (ABC) transporter F0362_20475 ENOG4105E09 nadh pyrophosphatase F0362_20480 ENOG4108QY0 Membrane F0362_20495 ENOG4105C7S Dehydrogenase F0362_20500 ENOG4105CPP Dehydrogenase, E1 component F0362_20520 ENOG4107RDP Dehydrogenase F0362_20535 ENOG4108JUB Transcriptional regulator F0362_20545 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F0362_20565 ENOG4107QQR Sporulation F0362_20575 ENOG4105S1Z Stage IV sporulation protein B F0362_20580 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F0362_20590 ENOG4105DX0 Hemolysin A F0362_20600 ENOG4105CTB Polyprenyl synthetase F0362_20615 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F0362_20620 ENOG4105M7K Involved in the transcription termination process (By similarity) F0362_20625 ENOG4108ZSR alkaline shock protein F0362_20630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F0362_20655 ENOG410644B Stage III sporulation protein af F0362_20665 ENOG4105KQ4 Stage iii sporulation protein ad F0362_20670 ENOG4108CQH stage III sporulation protein AC F0362_20675 ENOG4105KR5 Stage iii sporulation protein F0362_20680 ENOG4105CD2 stage iii sporulation protein aa F0362_20705 ENOG4105DC7 peptidase M24 F0362_20720 ENOG4105CBJ Metal-dependent enzyme F0362_20730 ENOG4107YBY Hydrolase F0362_20760 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) F0362_20765 ENOG4105WZW rhodanese family F0362_20790 ENOG41080TC multidrug resistance protein F0362_20820 ENOG4105CJ1 ABC, transporter F0362_20825 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family F0362_20840 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor F0362_20850 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) F0362_20855 ENOG4105C0D helicase F0362_20940 ENOG4107R6U sodium dicarboxylate symporter F0362_20980 ENOG4105C3R Methionine synthase F0362_20990 ENOG4105C28 cystathionine F0362_20995 ENOG4105C28 cystathionine F0362_21015 ENOG4105C5X domain protein F0362_21025 ENOG4105DKQ ROK family F0362_21035 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F0362_21055 ENOG4108UTW Plays a role in the regulation of phosphate uptake F0362_21060 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F0362_21065 ENOG4105E2Z phosphate ABC transporter (Permease F0362_21070 ENOG4105C8U phosphate abc transporter F0362_21075 ENOG4105PWN phosphate abc transporter F0362_21080 ENOG4107RF6 penicillin-binding protein F0362_21090 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0362_21115 ENOG4105N80 Ferric uptake regulator, Fur family F0362_21125 ENOG4105FDK ABC transporter F0362_21130 ENOG4108JYZ YitT family F0362_21135 ENOG41069ZM Protein of unknown function (DUF2624) F0362_21160 ENOG4105EGD dinuclear metal center protein, YbgI family F0362_21175 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0362_21180 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F0362_21185 ENOG4107XJU UPF0178 protein F0362_21210 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F0362_21215 ENOG4105KG3 cytidine deaminase F0362_21220 ENOG4107YR5 Diacylglycerol kinase F0362_21225 ENOG4107YVF Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) F0362_21230 ENOG4105CTJ Metal Dependent Phosphohydrolase F0362_21235 ENOG4105C9A Phoh family F0362_21245 ENOG41068P3 sporulation protein YqfC F0362_21250 ENOG4105KTH gatB Yqey F0362_21260 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F0362_21265 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F0362_21275 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F0362_21295 ENOG4105CSA Coproporphyrinogen iii oxidase F0362_21300 ENOG4105KVH Transcriptional regulator F0362_21325 ENOG4105TQK DNA polymerase iii, delta' subunit F0362_21335 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 F0362_21340 ENOG4108UK2 deaminase F0362_21345 ENOG4105KQC Competence protein F0362_21355 ENOG4105DXX methyltransferase F0362_21365 ENOG4108WF2 Metal Dependent Phosphohydrolase F0362_21370 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) F0362_21375 ENOG410812S Rna-binding protein F0362_21385 ENOG4105CQW ribosome biogenesis GTPase YqeH F0362_21390 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase F0362_21405 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0362_21425 ENOG4108TVJ Nitroreductase F0362_21440 ENOG4105G6Z alkaline phosphatase F0362_21450 ENOG4108MUZ hydrolase F0362_21485 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F0362_21490 ENOG4105MIR Phenylalanine 4-monooxygenase F0362_21500 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_21540 ENOG4105S6R Iron-hydroxamate transporter permease subunit F0362_21545 ENOG4108V5C ABC transporter F0362_21560 ENOG4108EKI Dehydrogenase F0362_21565 ENOG4105C28 cystathionine F0362_21595 ENOG4107XRG penicillin-binding protein F0362_21610 ENOG4105CFP Peptidase U32 F0362_21615 ENOG4105XYU peptidase (U32 family) F0362_21620 ENOG4108VQJ O-methyltransferase F0362_21625 ENOG4105HHA aminodeoxychorismate lyase F0362_21655 ENOG4105C02 permease F0362_21670 ENOG41060CR F0362_21675 ENOG4105C7H Helicase, RecD TraA family F0362_21685 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) F0362_21690 ENOG4105C3J Cysteine desulfurase F0362_21700 ENOG4105D1H recombination factor protein RarA F0362_21705 ENOG4108VCI transcription factor, rsfa family F0362_21720 ENOG4105CUZ uba thif-type nad fad binding protein F0362_21730 ENOG4105CUT histidyl-tRNA synthetase F0362_21755 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F0362_21765 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F0362_21770 ENOG41076HS cation diffusion facilitator family transporter F0362_21775 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F0362_21785 ENOG4105CKP Polysaccharide Biosynthesis Protein F0362_21790 ENOG4108QG2 Membrane F0362_21800 ENOG4105VIE preprotein translocase, subunit YajC F0362_21805 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) F0362_21815 ENOG41061AI Protein of unknown function (DUF2905) F0362_21820 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) F0362_21825 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) F0362_21830 ENOG4108HUF Transporter F0362_21860 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F0362_21865 ENOG4108IYU L-aspartate oxidase F0362_21880 ENOG4108RPX mosc domain containing protein F0362_21885 ENOG4105CQC Prephenate dehydratase F0362_21900 ENOG4105C19 ABC transporter F0362_21905 ENOG4105EWM Histidine kinase F0362_21930 ENOG4105X36 (ribosomal) protein F0362_21940 ENOG4105C03 ribonuclease F0362_21955 ENOG4107QMS site-determining protein F0362_21970 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) F0362_21975 ENOG4105DFF Rod shape-determining protein mreb F0362_22000 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F0362_22015 ENOG41068KH stage VI sporulation protein D F0362_22025 ENOG4105D52 delta-aminolevulinic acid dehydratase F0362_22050 ENOG4105K56 Transcriptional regulator F0362_22070 ENOG4108IUQ atp-dependent protease F0362_22095 ENOG4108QCI YvbH-like oligomerisation region F0362_22115 ENOG4105M59 Phosphodiesterase, mj0936 family F0362_22130 ENOG4108XJQ germination protein F0362_22145 ENOG4105PFC Transcriptional regulator F0362_22155 ENOG4105DZC cytosine deaminase F0362_22160 ENOG41067S9 phage shock protein C, PspC F0362_22165 ENOG4108JCI Transcriptional regulator F0362_22175 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F0362_22180 ENOG4108Z40 Transcriptional regulator F0362_22185 ENOG4105RHA ABC transporter, permease F0362_22190 ENOG4108IUX (ABC) transporter F0362_22195 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family F0362_22200 ENOG4105ER2 Ompa motb domain protein F0362_22205 ENOG4105E14 MotA TolQ exbB proton channel F0362_22210 ENOG4108VXD carboxy-peptidase F0362_22220 ENOG4105E33 succinate dehydrogenase F0362_22230 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit F0362_22245 ENOG4105K63 Thioredoxin F0362_22250 ENOG4105C10 Electron transfer flavoprotein F0362_22255 ENOG4105BZJ Electron transfer flavoprotein F0362_22260 ENOG41060WC Enoyl-CoA hydratase F0362_22265 ENOG4107Z3H Transcriptional regulator, TetR family F0362_22270 ENOG4105CEY Amp-dependent synthetase and ligase F0362_22280 ENOG4105J76 Periplasmic binding protein F0362_22285 ENOG4105S6R Iron-hydroxamate transporter permease subunit F0362_22335 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0362_22345 ENOG4105DR4 Methyltransferase F0362_22355 ENOG4105KFN sortase, SrtB family F0362_22360 ENOG4105E0A ABC, transporter F0362_22375 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) F0362_22385 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) F0362_22395 ENOG4105FE9 pseudouridine synthase F0362_22405 ENOG4105DCG PHP domain protein F0362_22415 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) F0362_22420 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F0362_22435 ENOG4105C5S asparaginyl-tRNA synthetase F0362_22440 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) F0362_22450 ENOG4108RWN rrna methyltransferase F0362_22485 ENOG4105C0R drug resistance transporter emrb qaca subfamily F0362_22490 ENOG4105CW7 secretion protein, HlyD family F0362_22495 ENOG4108JGH Tetr family transcriptional regulator F0362_22500 ENOG4105CN9 Peptidase m42 family protein F0362_22520 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) F0362_22525 ENOG4105C22 threonyL-tRNA synthetase F0362_22530 ENOG4108TDW sporulation protein YtxC F0362_22555 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) F0362_22560 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F0362_22565 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F0362_22575 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) F0362_22580 ENOG4105C2M dna polymerase I F0362_22585 ENOG4105BZU Histidine kinase F0362_22590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0362_22610 ENOG4108HMX isocitrate dehydrogenase (NADP) F0362_22615 ENOG4105BZN citrate synthase F0362_22630 ENOG4108REF Sporulation integral membrane protein ytvi F0362_22635 ENOG4105FS0 cytoplasmic membrane protein F0362_22640 ENOG4105CA9 Pyruvate kinase F0362_22660 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family F0362_22665 ENOG4105C6K Malic enzyme F0362_22670 ENOG4105C0B DNA polymerase III (alpha subunit) F0362_22675 ENOG4105VV2 F0362_22685 ENOG4105SFS phosphoesterase RecJ domain protein F0362_22710 ENOG4105DC7 peptidase M24 F0362_22745 ENOG41082W1 Cupin 2, conserved barrel domain protein F0362_22765 ENOG4107YZX Universal stress protein F0362_22770 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_22810 ENOG4108JYZ YitT family F0362_22830 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F0362_22840 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) F0362_22845 ENOG4105KBJ sporulation protein ytfj F0362_22860 ENOG4105EFZ amidohydrolase F0362_22870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F0362_22895 ENOG4106KR7 LysR family Transcriptional regulator F0362_22905 ENOG4105U5Y Transcriptional regulator F0362_22915 ENOG4105C28 cystathionine F0362_22940 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F0362_22950 ENOG4105EMN RNA polymerase sigma factor F0362_22960 ENOG4108UW5 maltose o-acetyltransferase F0362_22970 ENOG4105F1V Acetoin utilization protein F0362_22975 ENOG4105W87 Cbs domain F0362_22980 ENOG4105DGU Histone deacetylase F0362_22995 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F0362_23000 ENOG4105BZU Histidine kinase F0362_23005 ENOG4107SNB ankyrin repeat protein YahD F0362_23010 ENOG4105EP9 oxidoreductase F0362_23035 ENOG4105ETE Transcriptional regulator (LacI family F0362_23065 ENOG4105C88 aminopeptidase F0362_23090 ENOG4108IPJ Membrane F0362_23115 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F0362_23125 ENOG4108VDD TRNA binding domain protein F0362_23140 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F0362_23155 ENOG4105C8F Beta-lactamase domain protein F0362_23170 ENOG4108V15 phosphotransferase enzyme family F0362_23175 ENOG4108IUM Glycogen debranching enzyme F0362_23185 ENOG4107QSE Dipeptidase F0362_23190 ENOG4105YW5 deoR family transcriptional regulator F0362_23205 ENOG4105CBX hi0933 family F0362_23240 ENOG4108VJ1 Transcriptional regulator (CarD family F0362_23245 ENOG4107EXU Short-chain dehydrogenase reductase Sdr F0362_23265 ENOG4108ZAF Molybdopterin F0362_23270 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein F0362_23275 ENOG4105CVM Molybdenum cofactor synthesis domain protein F0362_23285 ENOG4105D06 uba thif-type nad fad binding protein F0362_23290 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F0362_23310 ENOG41085GJ domain protein F0362_23320 ENOG4105DWV Homoserine O-trans-acetylase F0362_23330 ENOG4108B31 Spore germination protein F0362_23365 ENOG410605W Major Facilitator F0362_23370 ENOG4107S91 Sodium hydrogen exchanger F0362_23375 ENOG4105NCW Trka-c domain protein F0362_23395 ENOG4105C19 ABC transporter F0362_23415 ENOG4105N5T Radical SAM Protein F0362_23445 ENOG4105E8V Alpha Beta Hydrolase Fold protein F0362_23450 ENOG4108Z0R Transferase F0362_23455 ENOG4105YVM Phosphoesterase, PA-phosphatase related F0362_23460 ENOG4105BZF Glycosyl transferase (Group 1 F0362_23470 ENOG4105EPU Molybdenum cofactor synthesis domain protein F0362_23520 ENOG4105BZU Histidine kinase F0362_23525 ENOG4105BZU Histidine kinase F0362_23535 ENOG4107S9D Alpha beta hydrolase F0362_23540 ENOG4107T7U Sulfatase F0362_23555 ENOG4105D2X ABC transporter substrate-binding protein F0362_23565 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component F0362_23580 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F0362_23630 ENOG4108V2W Carbonate dehydratase F0362_23635 ENOG4105C4M (Ubiquinol oxidase) subunit I F0362_23640 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F0362_23685 ENOG41087YS Phage shock protein A F0362_23715 ENOG4105BZU Histidine kinase F0362_23720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_23745 ENOG4108UGV hypoxanthine phosphoribosyltransferase F0362_23750 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) F0362_23780 ENOG4105C19 ABC transporter F0362_23795 ENOG4107ZTW SNARE associated Golgi F0362_23800 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) F0362_23810 ENOG4105C19 ABC transporter F0362_23815 ENOG41086D8 Transcriptional regulator F0362_23825 ENOG4105CJ1 ABC, transporter F0362_23835 ENOG41082BM Transcriptional regulator, arsr family F0362_23850 ENOG4105EMN RNA polymerase sigma factor F0362_23890 ENOG4105C6Z Gluconate F0362_23895 ENOG4105FDP GntR family transcriptional regulator F0362_23915 ENOG41069H0 dihydroorotase EC 3.5.2.3 F0362_23930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_23935 ENOG4105DTQ mandelate racemase muconate lactonizing F0362_23945 ENOG4108IPT Naphthoate synthase F0362_23950 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) F0362_23960 ENOG4105E4F Isochorismate synthase F0362_23965 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F0362_23975 ENOG4105VEQ Cold shock protein F0362_24010 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) F0362_24040 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F0362_24145 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation F0362_24180 ENOG4105KT7 mgtC SapB transporter F0362_24185 ENOG4107PBV potassium channel F0362_24205 ENOG4105WG9 Conserved Protein F0362_24215 ENOG4105CHM Aminotransferase F0362_24220 ENOG4108ZB6 transcriptional regulator AsnC family F0362_24225 ENOG4105C5I Dehydrogenase F0362_24230 ENOG4108MUZ hydrolase F0362_24240 ENOG4105C87 Aminotransferase class I and II F0362_24250 ENOG4105Y38 Kinase-associated protein B F0362_24260 ENOG4107R3E Citrate transporter F0362_24280 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) F0362_24285 ENOG4105KA0 thioesterase Superfamily protein F0362_24300 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F0362_24320 ENOG41069ER domain protein F0362_24335 ENOG4105CEP NADH dehydrogenase F0362_24365 ENOG4105EWC Purine nucleoside phosphorylase F0362_24390 ENOG4108YX9 iron--sulfur cluster insertion protein erpA F0362_24420 ENOG4105C4B ABC transporter, permease F0362_24425 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F0362_24465 ENOG41083MR nifu domain-containing protein F0362_24480 ENOG4108W5N phosphatidylglycerophosphatase a F0362_24505 ENOG4105DYS nad(p)h dehydrogenase (quinone) F0362_24515 ENOG4105D4U had-superfamily hydrolase, subfamily iia F0362_24530 ENOG4105CBT Fructose-1,6-bisphosphatase F0362_24550 ENOG4105MMD transcriptional regulator F0362_24555 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) F0362_24560 ENOG4107TXC Transcriptional regulator F0362_24565 ENOG41090T1 Membrane F0362_24590 ENOG4105FAA peptidase M23 F0362_24595 ENOG4108YTE sporulation protein YunB F0362_24600 ENOG4105KZD Domain of unknown function (DUF1805) F0362_24605 ENOG4107R8B 5'-nucleotidase F0362_24615 ENOG4105DIW FeS assembly protein SUFB F0362_24620 ENOG4108UNV SUF system FeS assembly protein, NifU family F0362_24625 ENOG4105C9B Cysteine desulfurase F0362_24630 ENOG4105JRK feS assembly protein SufD F0362_24635 ENOG4105C3K feS assembly ATPase SufC F0362_24640 ENOG4105D01 (LipO)protein F0362_24645 ENOG4105D01 (LipO)protein F0362_24650 ENOG4108UMI ABC transporter, permease F0362_24680 ENOG41080E8 Transcriptional regulator, Spx MgsR family F0362_24700 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F0362_24720 ENOG4108W8B Beta-lactamase domain protein F0362_24725 ENOG4105C1G acyl-Coa dehydrogenase F0362_24730 ENOG4105CHU acetyl-coa acetyltransferase F0362_24745 ENOG4105DZ1 carboxypeptidase F0362_24765 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer F0362_24780 ENOG4105F27 Major Facilitator F0362_24785 ENOG4107R7I amino acid F0362_24800 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F0362_24810 ENOG4107AYK membrAne F0362_24850 ENOG4107ZTW SNARE associated Golgi F0362_24860 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F0362_24865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_24870 ENOG4105BZU Histidine kinase F0362_24880 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F0362_24890 ENOG4105C8Q Methyl-accepting chemotaxis F0362_24895 ENOG4105C8Q Methyl-accepting chemotaxis F0362_24900 ENOG4105VG1 fes assembly suf system protein F0362_24905 ENOG4105D4Y metalloprotease F0362_24910 ENOG4105C2I pirin domain protein F0362_24925 ENOG4107T5V SNARE associated Golgi F0362_24930 ENOG4107S91 Sodium hydrogen exchanger F0362_24935 ENOG4105NCW Trka-c domain protein F0362_24945 ENOG4108RMU ferritin dps family protein F0362_24960 ENOG4108URH decarboxylase F0362_24970 ENOG41090A1 ferritin F0362_24975 ENOG4105DHF Membrane F0362_24980 ENOG4105D9N nucleoside F0362_24985 ENOG4105D9N nucleoside F0362_25000 ENOG4108RYK Nad-dependent epimerase dehydratase F0362_25015 ENOG4105CV8 reductase F0362_25025 ENOG4105F27 Major Facilitator F0362_25030 ENOG4105KVH Transcriptional regulator F0362_25045 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F0362_25050 ENOG4105D4A Cell wall formation (By similarity) F0362_25060 ENOG4105C8Q Methyl-accepting chemotaxis F0362_25070 ENOG4105WMR Protein CrcB homolog F0362_25075 ENOG4105WMR Protein CrcB homolog F0362_25095 ENOG4105C5H ABC transporter F0362_25100 ENOG4108MK9 spermidine N(1)-acetyltransferase F0362_25105 ENOG4108VY7 phosphate-starvation-inducible protein PsiE F0362_25115 ENOG4108W2Y isochorismatase F0362_25135 ENOG4108V2W Carbonate dehydratase F0362_25140 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) F0362_25155 ENOG4108IPW abc transporter atp-binding protein F0362_25160 ENOG4105CM4 permease protein F0362_25250 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F0362_25260 ENOG4105XZU Preprotein translocase, subunit SecG F0362_25265 ENOG41067MG lrgb family F0362_25315 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0362_25345 ENOG41090VF Stage v sporulation protein ac F0362_25350 ENOG4105CZ3 stage V sporulation protein ad F0362_25365 ENOG4108QY0 Membrane F0362_25370 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F0362_25375 ENOG4105KRI phosphocarrier protein (HPr F0362_25385 ENOG4105CHW UPF0052 protein F0362_25390 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) F0362_25395 ENOG4108Z4K mutator MutT protein F0362_25405 ENOG4105C3M thioredoxin reductase F0362_25415 ENOG4108S4C acetyltransferase F0362_25435 ENOG41086DT Membrane protein of unknown function F0362_25445 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F0362_25450 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) F0362_25460 ENOG4107TXC Transcriptional regulator F0362_25475 ENOG4105HMI Membrane F0362_25480 ENOG4105DUM transcriptional regulator, lysR family F0362_25490 ENOG4108WS4 fmn reductase F0362_25505 ENOG4105BZ1 (ABC) transporter F0362_25515 ENOG4105CN1 protease F0362_25520 ENOG4105CRP Part of the ABC transporter FtsEX involved in F0362_25525 ENOG4105CAK Cell division ATP-binding protein ftsE F0362_25545 ENOG4105MS2 ribosomal subunit Interface protein F0362_25550 ENOG4105VEQ Cold shock protein F0362_25555 ENOG41081UC Inherit from COG: Competence protein F0362_25570 ENOG4105KVH Transcriptional regulator F0362_25580 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein F0362_25585 ENOG4108KGH TRANSCRIPTIONal F0362_25590 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F0362_25595 ENOG4105C6Y Udp-glucose 6-dehydrogenase F0362_25600 ENOG4105ESV Glycosyl transferase, family 4 F0362_25610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F0362_25630 ENOG4105F8D glycoside hydrolase family 4 F0362_25635 ENOG4105VCP PTS System F0362_25640 ENOG4105CK1 PTS System F0362_25660 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) F0362_25665 ENOG4105VCP PTS System F0362_25675 ENOG4105VZJ PTS System F0362_25690 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_25695 ENOG4105ECB domain protein F0362_25700 ENOG4107RSM transcriptional regulator F0362_25730 ENOG4105DAA L-lactate F0362_25740 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) F0362_25755 ENOG4105E0M Sulfatase F0362_25780 ENOG4107R8N Glycosyl transferase, family 2 F0362_25785 ENOG4105C94 Transporter F0362_25795 ENOG41069ER domain protein F0362_25805 ENOG4105KBK Zinc finger, swim domain protein F0362_25810 ENOG4105C0D helicase F0362_25850 ENOG4107RBB ABC transporter, permease F0362_25855 ENOG4105C19 ABC transporter F0362_25865 ENOG4105CXY transporter F0362_25880 ENOG41062D9 Histidine kinase F0362_25885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_25890 ENOG4105CMR udp-glucose 4-epimerase F0362_25900 ENOG4106MCE EamA-like transporter family F0362_25905 ENOG4108KN0 Choline kinase F0362_25910 ENOG4105KPE licD family F0362_25920 ENOG4108KGH TRANSCRIPTIONal F0362_25925 ENOG4105D5D udp-galactopyranose mutase F0362_25940 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) F0362_25945 ENOG4108KMV Glycosyl transferase (Group 1 F0362_25960 ENOG4105C6Y Udp-glucose 6-dehydrogenase F0362_25975 ENOG4105D3Q Sugar transferase F0362_25985 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F0362_25990 ENOG4108RB3 Capsular polysaccharide biosynthesis protein F0362_25995 ENOG4107YJ4 chain length determinant protein F0362_26000 ENOG4105HTX biosynthesis protein F0362_26005 ENOG4107YJ4 chain length determinant protein F0362_26020 ENOG4105MT0 Sporulation transcriptional regulator spoiiid F0362_26030 ENOG4105FRN stage II sporulation protein F0362_26045 ENOG4105DY9 regulatoR F0362_26065 ENOG4106778 Protein of unknown function (DUF1146) F0362_26070 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0362_26075 ENOG4105C8S subunit m F0362_26080 ENOG4105D65 subunit l F0362_26105 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F0362_26110 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F0362_26120 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F0362_26125 ENOG4105BZU Histidine kinase F0362_26160 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) F0362_26180 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) F0362_26185 ENOG41062M3 atp synthase F0362_26215 ENOG4108YZG isomerase F0362_26230 ENOG4108VGI doxx family F0362_26235 ENOG4107XC4 flavin reductase domain protein, FMN-binding F0362_26250 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F0362_26260 ENOG4108ZXQ stage ii sporulation protein r F0362_26265 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F0362_26275 ENOG4107104 thymidine kinase F0362_26285 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F0362_26290 ENOG4105CBT Fructose-1,6-bisphosphatase F0362_26295 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F0362_26335 ENOG4105C1G acyl-Coa dehydrogenase F0362_26340 ENOG4105C1G acyl-Coa dehydrogenase F0362_26345 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F0362_26355 ENOG4105DF6 Fe-S oxidoreductase F0362_26375 ENOG4105BZU Histidine kinase F0362_26390 ENOG4105D4Y metalloprotease F0362_26400 ENOG4105BZU Histidine kinase F0362_26405 ENOG4105KCT ABC transporter F0362_26410 ENOG4108M15 ABC transporter F0362_26415 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) F0362_26420 ENOG4105IIU Aminopeptidase F0362_26435 ENOG410684U Domain of unknown function (DUF1934) F0362_26455 ENOG4105CYW agmatinase F0362_26460 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) F0362_26465 ENOG4105DXB Major Facilitator superfamily F0362_26470 ENOG4107SWG transcriptional regulator MERR family F0362_26475 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F0362_26480 ENOG4105BZ4 penicillin-binding protein F0362_26485 ENOG4108XFG YwhD family F0362_26490 ENOG4108Z4T Peptidase M50 F0362_26495 ENOG41069HH 4-oxalocrotonate tautomerase F0362_26500 ENOG4105DCI Phosphohydrolase F0362_26505 ENOG4108MES Periplasmic binding protein F0362_26510 ENOG4105E0A ABC, transporter F0362_26515 ENOG4105EHG Permease protein F0362_26520 ENOG4105DQ5 transport system permease protein F0362_26530 ENOG4108VCI transcription factor, rsfa family F0362_26535 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) F0362_26540 ENOG4108IJ2 phosphate acetyltransferase F0362_26545 ENOG4107UEZ chlorite dismutase F0362_26560 ENOG4108VKI Cell wall hydrolase F0362_26580 ENOG4107SVH Potassium channel protein F0362_26590 ENOG410667J hydrolase F0362_26595 ENOG4105VCH membrane F0362_26605 ENOG4108TU7 Inherit from COG: (ABC) transporter F0362_26610 ENOG4105CJ1 ABC, transporter F0362_26615 ENOG41090WU lipolytic protein G-D-S-L family F0362_26630 ENOG4105D6E homoserine dehydrogenase F0362_26655 ENOG4108Y4K DNA-binding transcriptional activator F0362_26665 ENOG4105WH1 Two component transcriptional regulator luxr family F0362_26670 ENOG4105BZU Histidine kinase F0362_26675 ENOG4105DWF phosphomethylpyrimidine kinase F0362_26680 ENOG4105BZU Histidine kinase F0362_26685 ENOG4105VCD cytoplasmic protein F0362_26690 ENOG4105D22 carbon starvation protein F0362_26695 ENOG4105DY9 regulatoR F0362_26700 ENOG41079KZ Major Facilitator Superfamily F0362_26715 ENOG4105CG5 Glycosyl transferase (Group 1 F0362_26725 ENOG4105EN6 Membrane F0362_26730 ENOG4106YBV Methyl-accepting chemotaxis F0362_26740 ENOG4108S4H thioesterase Superfamily protein F0362_26760 ENOG4108IG5 Transcriptional regulator F0362_26765 ENOG4105C5H ABC transporter F0362_26780 ENOG4105CKK Glycosyl transferase, family 2 F0362_26785 ENOG41067SE Tetr family transcriptional regulator F0362_26795 ENOG4105E0X reductase F0362_26800 ENOG4106F5Q Membrane F0362_26815 ENOG4108NEV two component transcriptional regulator, LytTR family F0362_26820 ENOG4108HRK Histidine kinase F0362_26825 ENOG4107RGD Major Facilitator superfamily F0362_26845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F0362_26855 ENOG4105IW1 AmiS UreI transporter F0362_26870 ENOG4105CMR udp-glucose 4-epimerase F0362_26875 ENOG4108UT2 hemolysin iii F0362_26885 ENOG4105C1J atp-dependent rna helicase F0362_26895 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) F0362_26900 ENOG4105DPN Oligoendopeptidase f F0362_26920 ENOG4105C0H protease F0362_26925 ENOG4105Q2H domain protein F0362_26940 ENOG4105BZU Histidine kinase F0362_26945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_26970 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis F0362_26975 ENOG4105CDU Replicative dna helicase F0362_26985 ENOG4105BZR domain protein F0362_26990 ENOG4108XMW Membrane F0362_27000 ENOG4108UUM single-stranded DNA-binding protein F0362_27010 ENOG4105C3G gtp-binding protein F0362_27015 ENOG4105VDK protein, conserved in bacteria F0362_27020 ENOG4105D8X mechanosensitive ion channel F0362_27025 ENOG4108ZDA Sporulation protein YyaC F0362_27030 ENOG4105FA0 parb-like partition protein F0362_27035 ENOG4107QJE Chromosome Partitioning Protein F0362_27065 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F0362_27125 ENOG4108IND Tetr family transcriptional regulator F0362_27225 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F0362_27265 ENOG4105W5Q DNA repair protein (RadC F0362_27270 ENOG4105ETE Transcriptional regulator (LacI family F0362_27275 ENOG4105IE8 Alpha-ketoglutarate permease F0362_27285 ENOG4105CK5 oxidoreductase F0362_27310 ENOG4105D2N Aldolase F0362_27315 ENOG4105DH8 myo-inositol catabolism F0362_27335 ENOG4107JM4 Tetratricopeptide repeat F0362_27360 ENOG4105D7V transposase F0362_27375 ENOG4105KRN Transcriptional regulator, abrb family F0362_27405 ENOG410780I phosphoprotein phosphatase activity F0362_27460 ENOG4108VXD carboxy-peptidase F0362_27530 ENOG4107XGZ Hydrolase F0362_27560 ENOG4105YWU small acid-soluble spore protein F0362_27590 ENOG4107QQG Dehydrogenase F0362_27600 ENOG4105BZN citrate synthase F0362_27620 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) F0362_27625 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase F0362_27655 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) F0362_27665 ENOG410609C Acyl carrier protein F0362_27690 ENOG4105DQ6 Transposase F0362_27695 ENOG4105BZ1 (ABC) transporter F0362_27710 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F0362_27715 ENOG4105E4F Isochorismate synthase F0362_27720 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F0362_27725 ENOG4105W8Z 4'-phosphopantetheinyl transferase F0362_27760 ENOG4105WQI isochorismatase F0362_27765 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F0362_27770 ENOG4105CEY Amp-dependent synthetase and ligase F0362_27815 ENOG4105VZ8 Transcriptional regulator F0362_27835 ENOG4105D7V transposase F0362_27960 ENOG4105K70 DNA-binding protein F0362_27980 ENOG4105EQ0 Major Facilitator superfamily F0362_27985 ENOG4108JGH Tetr family transcriptional regulator F0362_28040 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F0362_28045 ENOG4105D7V transposase F0362_28110 ENOG4108VQT Alpha beta hydrolase fold protein F0362_28130 ENOG4105CMG Carbohydrate kinase F0362_28140 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) F0362_28195 ENOG4105K4H Nlp p60 protein F0362_28370 ENOG4105D7V transposase F0362_28450 ENOG4105IIP Membrane F0362_28480 ENOG4105BZU Histidine kinase F0362_28485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_28490 ENOG4105C0H protease F0362_28495 ENOG4107WD8 ABC transporter, permease F0362_28520 ENOG4105D7V transposase F0362_28530 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin F0362_28570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_28580 ENOG4105D7V transposase F0362_28605 ENOG4105C19 ABC transporter F0362_28625 ENOG4108B31 Spore germination protein F0362_28660 ENOG41085FC arsR family transcriptional regulator F0362_28665 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase F0362_28670 ENOG4105D6J arsenicaL-resistance protein F0362_28685 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F0362_28710 ENOG4108D32 Methyltransferase F0362_28720 ENOG4108IUW ABC transporter F0362_28740 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F0362_28745 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F0362_28750 ENOG4105EUJ GTP cyclohydrolase i F0362_28765 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid F0362_28770 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) F0362_28780 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F0362_28795 ENOG4105GZI Transcriptional regulator F0362_28800 ENOG4105F27 Major Facilitator F0362_28890 ENOG4105BZU Histidine kinase F0362_28900 ENOG4108UHE carbonic anhydrase F0362_28920 ENOG4105EXC Acyl-transferase F0362_28930 ENOG4107VMI polysaccharide deacetylase F0362_28935 ENOG4105DCF alanine dehydrogenase F0362_28940 ENOG4108K8K Transcriptional regulator F0362_28975 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) F0362_28980 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase F0362_28985 ENOG4105CUB amino acid F0362_28995 ENOG4105II7 pyrroline-5-carboxylate reductase F0362_29000 ENOG4105C6K Malic enzyme F0362_29010 ENOG4108NHD germination protein F0362_29015 ENOG4108Q8B Spore germination protein F0362_29035 ENOG4105CSV Glutaminase F0362_29055 ENOG4105CS2 ec 3.2.1.21 F0362_29060 ENOG4105C5Y PTS System F0362_29065 ENOG4105CID antiterminator F0362_29075 ENOG41067TZ transcriptional regulator, MarR family F0362_29095 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF F0362_29105 ENOG41067TZ transcriptional regulator, MarR family F0362_29120 ENOG4107ZXU DSBA oxidoreductase F0362_29160 ENOG4108VJ1 Transcriptional regulator (CarD family F0362_29185 ENOG4105DPN Oligoendopeptidase f F0362_29275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F0362_29295 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein F0362_29310 ENOG4108IBT Inherit from COG: transposase F0362_29345 ENOG4105VZ8 Transcriptional regulator F0362_29715 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F0362_29785 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F0362_29790 ENOG4108ZHR arsR family transcriptional regulator F0362_29795 ENOG4108SQ9 flavin reductase domain protein, FMN-binding F0362_29835 ENOG4105D4Y metalloprotease F0362_29845 ENOG4105DU0 nucleoside hydrolase F0362_29870 ENOG4105CJ1 ABC, transporter F0362_29890 ENOG4108KF3 Electron transport protein SCO1 SenC F0362_29895 ENOG4106048 Cupin 2, conserved barrel domain protein F0362_29905 ENOG4105CYW agmatinase F0362_29910 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) F0362_29915 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F0362_29925 ENOG4105MWK D-amino acid dehydrogenase, small subunit F0362_29930 ENOG4105KD7 acetyltransferase F0362_29955 ENOG4105D7V transposase F0362_29970 ENOG4108MRH transcriptional regulatory protein F0362_30165 ENOG4105KIR Thiol-disulfide oxidoreductase dcc F0362_30285 ENOG4105D7V transposase F0362_30330 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)