locus-tag	class	description
K8M08_00005	COG1012	belongs to the aldehyde dehydrogenase family
K8M08_00010	COG1115	amino acid carrier protein
K8M08_00015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K8M08_00030	COG3397	chitin binding
K8M08_00055	COG4637	Psort location Cytoplasmic, score
K8M08_00085	COG0514	ATP-dependent DNA helicase (RecQ)
K8M08_00105	COG3973	AAA domain
K8M08_00155	COG0658	competence protein
K8M08_00155	COG2333	competence protein COMEC
K8M08_00165	COG2315	Protein conserved in bacteria
K8M08_00170	COG2226	methyltransferase
K8M08_00175	COG2205	protein histidine kinase activity
K8M08_00195	COG1819	glycosyl
K8M08_00200	COG3397	chitin binding
K8M08_00205	COG2153	protein acetylation
K8M08_00235	COG0517	IMP dehydrogenase activity
K8M08_00235	COG4175	Glycine betaine
K8M08_00240	COG4176	ABC-type proline glycine betaine transport system permease component
K8M08_00280	COG0456	acetyltransferase
K8M08_00280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K8M08_00285	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_00295	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8M08_00300	COG0022	dehydrogenase e1 component
K8M08_00305	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8M08_00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8M08_00330	COG1349	DNA-binding transcription factor activity
K8M08_00345	COG3284	Transcriptional regulator
K8M08_00365	COG1309	transcriptional regulator
K8M08_00405	COG2959	enzyme of heme biosynthesis
K8M08_00420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_00460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_00465	COG0697	spore germination
K8M08_00475	COG0201	protein transport
K8M08_00485	COG3227	Zinc metalloprotease (Elastase)
K8M08_00490	COG1523	belongs to the glycosyl hydrolase 13 family
K8M08_00510	COG1011	Hydrolase
K8M08_00535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8M08_00575	COG0322	excinuclease ABC activity
K8M08_00615	COG4667	esterase of the alpha-beta hydrolase superfamily
K8M08_00635	COG3878	Protein conserved in bacteria
K8M08_00670	COG0592	DNA-directed DNA polymerase activity
K8M08_00675	COG2816	NAD+ diphosphatase activity
K8M08_00690	COG2223	nitrite transmembrane transporter activity
K8M08_00700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8M08_00735	COG0697	spore germination
K8M08_00740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_00755	COG0584	glycerophosphoryl diester phosphodiesterase
K8M08_00770	COG2814	Major facilitator Superfamily
K8M08_00780	COG0693	protein deglycase activity
K8M08_00830	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_00840	COG0768	penicillin binding
K8M08_00845	COG0671	phosphoesterase, PA-phosphatase related
K8M08_00850	COG0604	alcohol dehydrogenase
K8M08_00855	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K8M08_00865	COG2205	protein histidine kinase activity
K8M08_00890	COG1794	racemase activity, acting on amino acids and derivatives
K8M08_00895	COG1819	glycosyl
K8M08_00905	COG5002	protein histidine kinase activity
K8M08_00910	COG0561	phosphatase activity
K8M08_00945	COG2124	cytochrome p450
K8M08_01065	COG0740	serine-type endopeptidase activity
K8M08_01075	COG4626	Terminase
K8M08_01075	COG1802	Transcriptional regulator
K8M08_01120	COG0582	viral genome integration into host DNA
K8M08_01140	COG0662	Cupin 2, conserved barrel domain protein
K8M08_01180	COG1484	DNA-dependent DNA replication
K8M08_01230	COG0582	viral genome integration into host DNA
K8M08_01260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K8M08_01270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_01275	COG0460	homoserine dehydrogenase
K8M08_01295	COG0577	efflux transmembrane transporter activity
K8M08_01300	COG1136	(ABC) transporter
K8M08_01315	COG0488	(ABC) transporter
K8M08_01325	COG2205	protein histidine kinase activity
K8M08_01330	COG0745	RESPONSE REGULATOR receiver
K8M08_01340	COG3773	Cell wall hydrolase
K8M08_01355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K8M08_01360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K8M08_01365	COG2323	membrane
K8M08_01385	COG2368	4-hydroxyphenylacetate
K8M08_01395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_01425	COG2226	methyltransferase
K8M08_01430	COG1733	regulation of RNA biosynthetic process
K8M08_01435	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_01460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K8M08_01475	COG3227	Zinc metalloprotease (Elastase)
K8M08_01495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K8M08_01520	COG1686	Belongs to the peptidase S11 family
K8M08_01525	COG2318	DinB family
K8M08_01535	COG0572	uridine kinase
K8M08_01555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8M08_01560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8M08_01565	COG1024	Enoyl-CoA hydratase
K8M08_01570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K8M08_01575	COG0511	ligase activity, forming carbon-carbon bonds
K8M08_01580	COG0439	Biotin carboxylase
K8M08_01585	COG1960	acyl-CoA dehydrogenase activity
K8M08_01600	COG1309	transcriptional regulator
K8M08_01610	COG1131	(ABC) transporter
K8M08_01635	COG0584	glycerophosphoryl diester phosphodiesterase
K8M08_01690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_01695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K8M08_01710	COG1131	(ABC) transporter
K8M08_01720	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K8M08_01765	COG1404	Belongs to the peptidase S8 family
K8M08_01770	COG2197	response regulator
K8M08_01775	COG4585	Histidine kinase
K8M08_01815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_01825	COG2755	lipolytic protein G-D-S-L family
K8M08_01825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K8M08_01835	COG3773	Cell wall hydrolase
K8M08_01850	COG3718	enzyme involved in inositol metabolism
K8M08_01880	COG0673	inositol 2-dehydrogenase activity
K8M08_01885	COG2814	Major facilitator Superfamily
K8M08_01890	COG1609	Transcriptional regulator
K8M08_01900	COG2367	Beta-lactamase
K8M08_01905	COG0768	penicillin binding
K8M08_01910	COG0768	penicillin binding
K8M08_01920	COG1595	DNA-templated transcription, initiation
K8M08_01925	COG0768	penicillin binding
K8M08_01935	COG0110	maltose O-acetyltransferase activity
K8M08_01945	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8M08_01975	COG1846	Transcriptional regulator
K8M08_01980	COG3961	Belongs to the TPP enzyme family
K8M08_01990	COG0500	methyltransferase
K8M08_01990	COG3615	Tellurite resistance protein tehB
K8M08_01995	COG0577	efflux transmembrane transporter activity
K8M08_01995	COG1136	(ABC) transporter
K8M08_02010	COG1309	transcriptional regulator
K8M08_02045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_02065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K8M08_02075	COG2971	BadF BadG BcrA BcrD
K8M08_02100	COG1649	PFAM Uncharacterised BCR, COG1649
K8M08_02125	COG1595	DNA-templated transcription, initiation
K8M08_02130	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
K8M08_02140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8M08_02170	COG1396	sequence-specific DNA binding
K8M08_02190	COG1132	(ABC) transporter
K8M08_02195	COG1132	(ABC) transporter
K8M08_02210	COG2258	MOSC domain
K8M08_02215	COG0583	DNA-binding transcription factor activity
K8M08_02230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8M08_02235	COG0583	DNA-binding transcription factor activity
K8M08_02245	COG0561	phosphatase activity
K8M08_02250	COG0010	Belongs to the arginase family
K8M08_02265	COG1278	Cold shock
K8M08_02275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_02285	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K8M08_02290	COG0596	Alpha beta hydrolase
K8M08_02315	COG1247	-acetyltransferase
K8M08_02345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_02360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8M08_02395	COG2226	methyltransferase
K8M08_02405	COG0028	Belongs to the TPP enzyme family
K8M08_02420	COG2814	Major facilitator Superfamily
K8M08_02425	COG0596	Alpha beta hydrolase
K8M08_02435	COG1136	(ABC) transporter
K8M08_02445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K8M08_02450	COG1187	pseudouridine synthase activity
K8M08_02455	COG2329	Antibiotic biosynthesis monooxygenase
K8M08_02480	COG1115	amino acid carrier protein
K8M08_02490	COG2318	DinB family
K8M08_02500	COG0776	regulation of translation
K8M08_02515	COG2814	Major facilitator Superfamily
K8M08_02520	COG3251	PFAM MbtH domain protein
K8M08_02525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8M08_02530	COG1535	isochorismatase
K8M08_02530	COG3433	isochorismatase activity
K8M08_02535	COG1021	2,3-dihydroxybenzoate-AMP ligase
K8M08_02540	COG1169	isochorismate synthase
K8M08_02545	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_02550	COG2223	nitrite transmembrane transporter activity
K8M08_02575	COG0420	3'-5' exonuclease activity
K8M08_02590	COG1024	Enoyl-CoA hydratase
K8M08_02595	COG1280	lysine exporter protein (LysE YggA)
K8M08_02605	COG2084	Dehydrogenase
K8M08_02610	COG1960	acyl-CoA dehydrogenase activity
K8M08_02615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K8M08_02620	COG2079	MmgE PrpD family protein
K8M08_02625	COG0372	Belongs to the citrate synthase family
K8M08_02630	COG4841	protein insertion into membrane
K8M08_02635	COG2814	Major facilitator Superfamily
K8M08_02645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8M08_02645	COG4499	WXG100 protein secretion system (Wss), protein YukC
K8M08_02665	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_02695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8M08_02730	COG1595	DNA-templated transcription, initiation
K8M08_02785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8M08_02790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8M08_02795	COG0671	phosphoesterase, PA-phosphatase related
K8M08_02800	COG4326	sporulation control protein
K8M08_02805	COG3064	Membrane
K8M08_02805	COG4991	sh3 domain protein
K8M08_02805	COG0515	serine threonine protein kinase
K8M08_02840	COG1509	lysine 2,3-aminomutase activity
K8M08_02845	COG3829	transcription factor binding
K8M08_02850	COG0456	acetyltransferase
K8M08_02855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8M08_02860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K8M08_02865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K8M08_02870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8M08_02885	COG5506	Protein of unknown function (DUF1694)
K8M08_02890	COG1012	belongs to the aldehyde dehydrogenase family
K8M08_02895	COG1253	flavin adenine dinucleotide binding
K8M08_02930	COG1174	glycine betaine transport
K8M08_02935	COG0517	IMP dehydrogenase activity
K8M08_02935	COG1125	glycine betaine transport
K8M08_03005	COG1064	alcohol dehydrogenase
K8M08_03015	COG2197	response regulator
K8M08_03020	COG2203	Gaf domain
K8M08_03020	COG4585	Histidine kinase
K8M08_03025	COG0668	transmembrane transport
K8M08_03030	COG0071	Belongs to the small heat shock protein (HSP20) family
K8M08_03035	COG1051	belongs to the nudix hydrolase family
K8M08_03040	COG1335	isochorismatase
K8M08_03055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8M08_03060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_03080	COG0367	asparagine synthase
K8M08_03085	COG0071	Belongs to the small heat shock protein (HSP20) family
K8M08_03090	COG1999	signal sequence binding
K8M08_03095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K8M08_03100	COG1307	EDD domain protein, DegV family
K8M08_03110	COG0805	protein transport
K8M08_03120	COG1272	protein, Hemolysin III
K8M08_03125	COG0204	Acyl-transferase
K8M08_03135	COG0768	penicillin binding
K8M08_03150	COG3250	beta-galactosidase activity
K8M08_03155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8M08_03170	COG0546	phosphoglycolate phosphatase activity
K8M08_03180	COG4473	ABC transporter
K8M08_03185	COG1131	(ABC) transporter
K8M08_03195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K8M08_03200	COG0456	acetyltransferase
K8M08_03210	COG1794	racemase activity, acting on amino acids and derivatives
K8M08_03215	COG1454	alcohol dehydrogenase
K8M08_03220	COG2610	gluconate transmembrane transporter activity
K8M08_03245	COG0733	neurotransmitter:sodium symporter activity
K8M08_03305	COG1674	ftsk spoiiie
K8M08_03325	COG0017	Asparaginyl-tRNA synthetase
K8M08_03330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K8M08_03375	COG2136	Putative SAM-dependent methyltransferase
K8M08_03375	COG2521	methyltransferase
K8M08_03390	COG1413	lyase activity
K8M08_03395	COG0629	single-stranded DNA binding
K8M08_03410	COG0488	(ABC) transporter
K8M08_03415	COG1418	mRNA catabolic process
K8M08_03440	COG2359	stage V sporulation protein S
K8M08_03465	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
K8M08_03470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8M08_03475	COG2146	nitrite reductase [NAD(P)H] activity
K8M08_03480	COG1587	Uroporphyrinogen-III synthase
K8M08_03480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K8M08_03490	COG1648	precorrin-2 dehydrogenase activity
K8M08_03505	COG2223	nitrite transmembrane transporter activity
K8M08_03515	COG0314	molybdopterin synthase activity
K8M08_03520	COG0303	'Molybdopterin
K8M08_03525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8M08_03530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K8M08_03535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8M08_03540	COG2181	nitrate reductase activity
K8M08_03545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K8M08_03550	COG1140	nitrate reductase beta subunit
K8M08_03555	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K8M08_03560	COG0714	Associated with various cellular activities
K8M08_03565	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K8M08_03570	COG1305	Transglutaminase-like
K8M08_03575	COG0386	Belongs to the glutathione peroxidase family
K8M08_03605	COG1595	DNA-templated transcription, initiation
K8M08_03610	COG0604	alcohol dehydrogenase
K8M08_03620	COG0346	lactoylglutathione lyase activity
K8M08_03640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K8M08_03665	COG3874	Sporulation protein YtfJ
K8M08_03705	COG0456	acetyltransferase
K8M08_03735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_03740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_03745	COG1819	glycosyl
K8M08_03760	COG4106	trans-aconitate 2-methyltransferase activity
K8M08_03765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8M08_03775	COG0561	phosphatase activity
K8M08_03800	COG0154	amidase activity
K8M08_03805	COG0494	nUDIX hydrolase
K8M08_03810	COG1876	peptidase activity
K8M08_03820	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8M08_03840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8M08_03845	COG1114	Component of the transport system for branched-chain amino acids
K8M08_03860	COG1253	flavin adenine dinucleotide binding
K8M08_03865	COG2839	Protein conserved in bacteria
K8M08_03870	COG0702	epimerase
K8M08_03885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8M08_03895	COG1607	acyl-coa hydrolase
K8M08_03900	COG3689	TIGRFAM TIGR03943 family protein
K8M08_03905	COG0701	Predicted permease
K8M08_03915	COG2244	polysaccharide biosynthetic process
K8M08_03920	COG0586	Pfam SNARE associated Golgi protein
K8M08_03925	COG1051	belongs to the nudix hydrolase family
K8M08_03930	COG5337	Spore coat protein CotH
K8M08_03940	COG0406	alpha-ribazole phosphatase activity
K8M08_03955	COG4166	transmembrane transport
K8M08_03965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K8M08_03975	COG0702	epimerase
K8M08_03985	COG0803	Belongs to the bacterial solute-binding protein 9 family
K8M08_03985	COG3443	Belongs to the bacterial solute-binding protein 9 family
K8M08_04000	COG0456	acetyltransferase
K8M08_04005	COG0523	cobalamin synthesis protein
K8M08_04010	COG4989	oxidoreductase activity
K8M08_04015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_04020	COG1231	oxidoreductase activity
K8M08_04030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8M08_04045	COG0783	Belongs to the Dps family
K8M08_04050	COG3949	Membrane
K8M08_04090	COG2814	Major facilitator Superfamily
K8M08_04095	COG0667	Aldo Keto reductase
K8M08_04100	COG0640	Transcriptional regulator
K8M08_04105	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K8M08_04110	COG1404	Belongs to the peptidase S8 family
K8M08_04115	COG2002	toxin-antitoxin pair type II binding
K8M08_04120	COG0577	efflux transmembrane transporter activity
K8M08_04155	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8M08_04165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_04170	COG1279	arginine transmembrane transporter activity
K8M08_04175	COG2814	Major facilitator Superfamily
K8M08_04185	COG1082	Xylose isomerase domain protein TIM barrel
K8M08_04195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8M08_04215	COG1247	-acetyltransferase
K8M08_04220	COG1285	pathogenesis
K8M08_04235	COG5002	protein histidine kinase activity
K8M08_04240	COG0745	RESPONSE REGULATOR receiver
K8M08_04250	COG1316	TRANSCRIPTIONal
K8M08_04275	COG0460	homoserine dehydrogenase
K8M08_04305	COG4122	O-methyltransferase activity
K8M08_04310	COG0300	oxidoreductase activity
K8M08_04320	COG5002	protein histidine kinase activity
K8M08_04325	COG0745	RESPONSE REGULATOR receiver
K8M08_04330	COG1132	(ABC) transporter
K8M08_04340	COG1388	LysM domain
K8M08_04340	COG0791	NLP P60 protein
K8M08_04355	COG1686	Belongs to the peptidase S11 family
K8M08_04385	COG1216	Glycosyl transferase, family 2
K8M08_04395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K8M08_04400	COG4988	ABC transporter
K8M08_04405	COG1294	oxidase, subunit
K8M08_04410	COG1271	oxidase subunit
K8M08_04430	COG1942	4-Oxalocrotonate Tautomerase
K8M08_04440	COG0583	DNA-binding transcription factor activity
K8M08_04460	COG0411	ABC transporter
K8M08_04475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8M08_04480	COG2030	dehydratase
K8M08_04485	COG0318	PFAM AMP-dependent synthetase and ligase
K8M08_04495	COG0523	cobalamin synthesis protein
K8M08_04500	COG1231	oxidoreductase activity
K8M08_04510	COG0628	permease
K8M08_04520	COG0778	Nitroreductase
K8M08_04525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K8M08_04530	COG1959	2 iron, 2 sulfur cluster binding
K8M08_04535	COG0583	DNA-binding transcription factor activity
K8M08_04540	COG0697	spore germination
K8M08_04545	COG4549	nuclear export factor GLE1
K8M08_04550	COG1276	copper resistance
K8M08_04550	COG2372	response to copper ion
K8M08_04560	COG1114	Component of the transport system for branched-chain amino acids
K8M08_04585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8M08_04595	COG2132	Multicopper oxidase
K8M08_04600	COG0006	proline dipeptidase activity
K8M08_04610	COG4846	Membrane protein involved in cytochrome C biogenesis
K8M08_04625	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K8M08_04630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8M08_04640	COG2390	Transcriptional regulator
K8M08_04645	COG1309	transcriptional regulator
K8M08_04680	COG0531	amino acid
K8M08_04685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K8M08_04700	COG1914	H( )-stimulated, divalent metal cation uptake system
K8M08_04720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_04730	COG2226	methyltransferase
K8M08_04745	COG4166	transmembrane transport
K8M08_04750	COG1073	alpha beta
K8M08_04770	COG0427	acetyl-CoA hydrolase
K8M08_04775	COG3279	Response regulator of the LytR AlgR family
K8M08_04785	COG3384	dioxygenase
K8M08_04790	COG2814	Major facilitator Superfamily
K8M08_04815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K8M08_04835	COG0028	Belongs to the TPP enzyme family
K8M08_04840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8M08_04845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8M08_04865	COG2323	membrane
K8M08_04870	COG5566	PFAM Mor transcription activator
K8M08_04880	COG0733	neurotransmitter:sodium symporter activity
K8M08_04885	COG2244	polysaccharide biosynthetic process
K8M08_04900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8M08_04905	COG2223	nitrite transmembrane transporter activity
K8M08_04910	COG4166	transmembrane transport
K8M08_04915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K8M08_04925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8M08_04930	COG0477	Major facilitator Superfamily
K8M08_04975	COG1051	belongs to the nudix hydrolase family
K8M08_05005	COG3620	sequence-specific DNA binding
K8M08_05020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K8M08_05025	COG0784	Response regulator, receiver
K8M08_05030	COG4191	Histidine kinase
K8M08_05035	COG0281	malic enzyme
K8M08_05040	COG1027	Aspartate ammonia-lyase
K8M08_05050	COG0528	UMP kinase activity
K8M08_05055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8M08_05070	COG1131	(ABC) transporter
K8M08_05105	COG2733	membrane
K8M08_05145	COG3340	Belongs to the peptidase S51 family
K8M08_05150	COG0534	Mate efflux family protein
K8M08_05160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_05170	COG0114	fumarate hydratase activity
K8M08_05175	COG4221	oxidoreductase activity
K8M08_05180	COG0789	Transcriptional regulator
K8M08_05185	COG1757	Na H antiporter
K8M08_05190	COG0438	transferase activity, transferring glycosyl groups
K8M08_05190	COG1216	Glycosyl transferase, family 2
K8M08_05200	COG0701	Predicted permease
K8M08_05205	COG0523	cobalamin synthesis protein
K8M08_05210	COG0697	spore germination
K8M08_05215	COG1802	Transcriptional regulator
K8M08_05245	COG0367	asparagine synthase
K8M08_05255	COG1846	Transcriptional regulator
K8M08_05275	COG0406	alpha-ribazole phosphatase activity
K8M08_05285	COG1686	Belongs to the peptidase S11 family
K8M08_05315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K8M08_05330	COG3842	ATPase activity
K8M08_05335	COG0583	DNA-binding transcription factor activity
K8M08_05365	COG3764	Sortase (surface protein transpeptidase)
K8M08_05370	COG3764	Sortase (surface protein transpeptidase)
K8M08_05385	COG2329	Antibiotic biosynthesis monooxygenase
K8M08_05430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8M08_05435	COG4786	Flagellar basal body rod
K8M08_05440	COG1419	protein localization to endoplasmic reticulum
K8M08_05445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K8M08_05450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K8M08_05460	COG1987	bacterial-type flagellum assembly
K8M08_05465	COG1338	Plays a role in the flagellum-specific transport system
K8M08_05475	COG1776	CheC inhibitor of MCP methylation
K8M08_05475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8M08_05480	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8M08_05490	COG0741	lytic transglycosylase activity
K8M08_05495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8M08_05515	COG0784	Response regulator, receiver
K8M08_05515	COG0835	chemotaxis
K8M08_05550	COG1157	protein secretion by the type III secretion system
K8M08_05560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8M08_05565	COG1766	The M ring may be actively involved in energy transduction
K8M08_05575	COG1558	bacterial-type flagellum-dependent cell motility
K8M08_05580	COG1815	bacterial-type flagellum-dependent cell motility
K8M08_05595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K8M08_05600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8M08_05605	COG1256	bacterial-type flagellum assembly
K8M08_05625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K8M08_05640	COG1776	CheC inhibitor of MCP methylation
K8M08_05640	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8M08_05645	COG0643	Histidine kinase
K8M08_05645	COG2198	Histidine kinase
K8M08_05650	COG2201	protein-glutamate methylesterase activity
K8M08_05655	COG1360	Flagellar Motor Protein
K8M08_05660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8M08_05670	COG1923	regulation of RNA biosynthetic process
K8M08_05690	COG2814	Major facilitator Superfamily
K8M08_05700	COG2814	Major facilitator Superfamily
K8M08_05725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K8M08_05730	COG2323	membrane
K8M08_05740	COG0789	Transcriptional regulator
K8M08_05740	COG4978	Transcriptional regulator
K8M08_05745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K8M08_05750	COG0475	glutathione-regulated potassium exporter activity
K8M08_05760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8M08_05765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8M08_05770	COG3162	membrane
K8M08_05785	COG1280	lysine exporter protein (LysE YggA)
K8M08_05790	COG3403	YqcI/YcgG family
K8M08_05825	COG0328	RNA-DNA hybrid ribonuclease activity
K8M08_05845	COG0454	-acetyltransferase
K8M08_05860	COG0438	transferase activity, transferring glycosyl groups
K8M08_05865	COG1215	transferase activity, transferring glycosyl groups
K8M08_05880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8M08_05905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8M08_05920	COG0754	glutathionylspermidine amidase activity
K8M08_05955	COG0456	acetyltransferase
K8M08_05965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K8M08_05970	COG2311	Membrane
K8M08_05975	COG2233	PERMEase
K8M08_05985	COG0024	Methionine aminopeptidase
K8M08_05995	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K8M08_06000	COG1199	ATP-dependent helicase activity
K8M08_06010	COG0116	Belongs to the methyltransferase superfamily
K8M08_06070	COG4499	WXG100 protein secretion system (Wss), protein YukC
K8M08_06070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8M08_06080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K8M08_06085	COG3935	DnaD domain protein
K8M08_06105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K8M08_06105	COG1199	ATP-dependent helicase activity
K8M08_06140	COG0438	transferase activity, transferring glycosyl groups
K8M08_06145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K8M08_06160	COG1694	Mazg nucleotide pyrophosphohydrolase
K8M08_06165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_06175	COG2738	Putative neutral zinc metallopeptidase
K8M08_06190	COG4347	Protein of unknown function (DUF1405)
K8M08_06195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K8M08_06195	COG2010	Cytochrome c
K8M08_06200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K8M08_06220	COG0457	Tetratricopeptide repeat
K8M08_06245	COG0142	geranyltranstransferase activity
K8M08_06255	COG0142	geranyltranstransferase activity
K8M08_06270	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K8M08_06345	COG0492	ferredoxin-NADP+ reductase activity
K8M08_06365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K8M08_06370	COG4862	establishment of competence for transformation
K8M08_06380	COG1408	metallophosphoesterase
K8M08_06390	COG1266	CAAX protease self-immunity
K8M08_06395	COG0514	ATP-dependent DNA helicase (RecQ)
K8M08_06405	COG1141	Ferredoxin
K8M08_06410	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K8M08_06420	COG4942	peptidase
K8M08_06425	COG2096	Adenosyltransferase
K8M08_06430	COG5002	protein histidine kinase activity
K8M08_06435	COG0745	RESPONSE REGULATOR receiver
K8M08_06440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8M08_06445	COG1333	cytochrome c biogenesis protein
K8M08_06455	COG1187	pseudouridine synthase activity
K8M08_06460	COG0700	Nucleoside recognition
K8M08_06465	COG2715	membrane protein required for spore maturation
K8M08_06470	COG1686	Belongs to the peptidase S11 family
K8M08_06475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K8M08_06490	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K8M08_06490	COG0392	lysyltransferase activity
K8M08_06505	COG5002	protein histidine kinase activity
K8M08_06510	COG0582	viral genome integration into host DNA
K8M08_06520	COG1801	Protein of unknown function DUF72
K8M08_06525	COG3852	Histidine kinase
K8M08_06540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8M08_06545	COG1392	Phosphate transport regulator
K8M08_06550	COG0306	phosphate transporter
K8M08_06555	COG0730	response to heat
K8M08_06605	COG1114	Component of the transport system for branched-chain amino acids
K8M08_06615	COG2197	response regulator
K8M08_06620	COG4585	Histidine kinase
K8M08_06625	COG4758	membrane
K8M08_06640	COG1757	Na H antiporter
K8M08_06665	COG0733	neurotransmitter:sodium symporter activity
K8M08_06670	COG1648	precorrin-2 dehydrogenase activity
K8M08_06690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8M08_06695	COG0529	Catalyzes the synthesis of activated sulfate
K8M08_06715	COG0019	diaminopimelate decarboxylase activity
K8M08_06725	COG1368	sulfuric ester hydrolase activity
K8M08_06730	COG1183	phosphatidylcholine synthase activity
K8M08_06745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K8M08_06820	COG0440	acetolactate synthase activity
K8M08_06825	COG0028	Belongs to the TPP enzyme family
K8M08_06830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8M08_06850	COG3874	Sporulation protein YtfJ
K8M08_06855	COG4709	membrane
K8M08_06860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8M08_06865	COG1301	dicarboxylic acid transport
K8M08_06875	COG1846	Transcriptional regulator
K8M08_06895	COG0534	Mate efflux family protein
K8M08_06930	COG0716	FMN binding
K8M08_06965	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K8M08_06970	COG2070	2-Nitropropane dioxygenase
K8M08_06975	COG1619	proteins homologs of microcin C7 resistance protein MccF
K8M08_06985	COG1335	isochorismatase
K8M08_06995	COG1522	sequence-specific DNA binding
K8M08_07005	COG1266	CAAX protease self-immunity
K8M08_07010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K8M08_07015	COG1131	(ABC) transporter
K8M08_07025	COG1131	(ABC) transporter
K8M08_07030	COG1725	Transcriptional regulator
K8M08_07035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8M08_07050	COG1780	Probably involved in ribonucleotide reductase function
K8M08_07080	COG4873	Protein conserved in bacteria
K8M08_07095	COG0720	synthase
K8M08_07105	COG5002	protein histidine kinase activity
K8M08_07115	COG2318	DinB family
K8M08_07125	COG1846	Transcriptional regulator
K8M08_07130	COG3852	Histidine kinase
K8M08_07140	COG2861	carbohydrate metabolic process
K8M08_07150	COG0235	Class ii aldolase
K8M08_07160	COG1349	DNA-binding transcription factor activity
K8M08_07185	COG3842	ATPase activity
K8M08_07190	COG1840	ABC-type Fe3 transport system, periplasmic component
K8M08_07205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8M08_07215	COG3243	poly(R)-hydroxyalkanoic acid synthase
K8M08_07220	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_07240	COG2030	dehydratase
K8M08_07250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8M08_07255	COG0861	Integral membrane protein TerC family
K8M08_07260	COG2116	formate transmembrane transporter activity
K8M08_07270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K8M08_07290	COG2186	Transcriptional regulator
K8M08_07295	COG5002	protein histidine kinase activity
K8M08_07300	COG0745	RESPONSE REGULATOR receiver
K8M08_07310	COG3835	regulator
K8M08_07315	COG0277	FAD linked oxidase domain protein
K8M08_07320	COG0247	lactate metabolic process
K8M08_07325	COG2340	Cysteine-rich secretory protein family
K8M08_07335	COG0564	pseudouridine synthase activity
K8M08_07345	COG2409	Drug exporters of the RND superfamily
K8M08_07355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K8M08_07360	COG1177	transmembrane transport
K8M08_07365	COG1176	ABC-type spermidine putrescine transport system, permease component I
K8M08_07375	COG1012	belongs to the aldehyde dehydrogenase family
K8M08_07390	COG1396	sequence-specific DNA binding
K8M08_07410	COG0681	Belongs to the peptidase S26 family
K8M08_07415	COG1686	Belongs to the peptidase S11 family
K8M08_07425	COG2226	methyltransferase
K8M08_07495	COG1476	TRANSCRIPTIONal
K8M08_07505	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8M08_07565	COG5634	Uncharacterized conserved protein (DUF2278)
K8M08_07570	COG1620	l-lactate permease
K8M08_07605	COG0512	Glutamine amidotransferase of anthranilate synthase
K8M08_07605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K8M08_07615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8M08_07620	COG5492	domain, Protein
K8M08_07635	COG2382	esterase
K8M08_07645	COG2153	protein acetylation
K8M08_07690	COG1091	dTDP-4-dehydrorhamnose reductase activity
K8M08_07705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K8M08_07725	COG0457	Tetratricopeptide repeat
K8M08_07725	COG0463	Glycosyl transferase, family 2
K8M08_07745	COG1216	Glycosyl transferase, family 2
K8M08_07750	COG0772	Belongs to the SEDS family
K8M08_07765	COG0564	pseudouridine synthase activity
K8M08_07775	COG2357	RelA SpoT domain protein
K8M08_07785	COG4116	CYTH
K8M08_07790	COG2346	COG2346, Truncated hemoglobins
K8M08_07805	COG1164	Oligoendopeptidase f
K8M08_07815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8M08_07820	COG4862	establishment of competence for transformation
K8M08_07825	COG0861	Integral membrane protein TerC family
K8M08_07840	COG4166	transmembrane transport
K8M08_07845	COG0534	Mate efflux family protein
K8M08_07850	COG4608	Belongs to the ABC transporter superfamily
K8M08_07855	COG0444	Belongs to the ABC transporter superfamily
K8M08_07860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8M08_07865	COG0601	transmembrane transport
K8M08_07870	COG4166	transmembrane transport
K8M08_07880	COG0180	Tryptophanyl-tRNA synthetase
K8M08_07890	COG5504	Zn-dependent protease
K8M08_07895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8M08_07900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8M08_07915	COG2267	carboxylic ester hydrolase activity
K8M08_07925	COG0542	response to heat
K8M08_07935	COG0561	phosphatase activity
K8M08_07950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_07960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8M08_07965	COG2996	Protein conserved in bacteria
K8M08_07990	COG0004	ammonium transporteR
K8M08_07995	COG0753	catalase activity
K8M08_08005	COG0367	asparagine synthase
K8M08_08030	COG0179	Fumarylacetoacetate (FAA) hydrolase
K8M08_08090	COG0398	Pfam SNARE associated Golgi protein
K8M08_08100	COG4903	ComK protein
K8M08_08125	COG2224	Isocitrate lyase
K8M08_08130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K8M08_08150	COG0697	spore germination
K8M08_08155	COG0840	transmembrane signaling receptor activity
K8M08_08160	COG0501	Belongs to the peptidase M48B family
K8M08_08185	COG0745	RESPONSE REGULATOR receiver
K8M08_08190	COG2205	protein histidine kinase activity
K8M08_08205	COG2207	Transcriptional regulator
K8M08_08205	COG3708	Transcriptional regulator
K8M08_08210	COG1595	DNA-templated transcription, initiation
K8M08_08220	COG0477	Major facilitator Superfamily
K8M08_08230	COG1078	dGTPase activity
K8M08_08235	COG1408	metallophosphoesterase
K8M08_08240	COG1073	alpha beta
K8M08_08265	COG0318	PFAM AMP-dependent synthetase and ligase
K8M08_08275	COG0095	Lipoate-protein ligase
K8M08_08280	COG1234	tRNA 3'-trailer cleavage
K8M08_08290	COG1609	Transcriptional regulator
K8M08_08295	COG2378	regulation of single-species biofilm formation
K8M08_08320	COG1511	domain protein
K8M08_08325	COG1309	transcriptional regulator
K8M08_08350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K8M08_08365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8M08_08370	COG2329	Antibiotic biosynthesis monooxygenase
K8M08_08375	COG3428	Bacterial PH domain
K8M08_08380	COG3402	PFAM membrane-flanked domain
K8M08_08420	COG3428	Bacterial PH domain
K8M08_08425	COG3402	PFAM membrane-flanked domain
K8M08_08435	COG1309	transcriptional regulator
K8M08_08450	COG4473	ABC transporter
K8M08_08455	COG1131	(ABC) transporter
K8M08_08460	COG0537	adenosine 5'-monophosphoramidase activity
K8M08_08465	COG4980	gas vesicle protein
K8M08_08485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8M08_08490	COG3973	AAA domain
K8M08_08500	COG0772	Belongs to the SEDS family
K8M08_08510	COG1595	DNA-templated transcription, initiation
K8M08_08525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K8M08_08535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K8M08_08540	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K8M08_08560	COG2267	carboxylic ester hydrolase activity
K8M08_08565	COG0457	Tetratricopeptide repeat
K8M08_08570	COG0346	lactoylglutathione lyase activity
K8M08_08575	COG0346	lactoylglutathione lyase activity
K8M08_08580	COG2814	Major facilitator Superfamily
K8M08_08585	COG1309	transcriptional regulator
K8M08_08595	COG4717	serine-type aminopeptidase activity
K8M08_08600	COG0420	3'-5' exonuclease activity
K8M08_08670	COG0784	Response regulator, receiver
K8M08_08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8M08_08670	COG2198	Histidine kinase
K8M08_08670	COG2205	protein histidine kinase activity
K8M08_08675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K8M08_08680	COG2208	phosphoserine phosphatase activity
K8M08_08690	COG1191	sigma factor activity
K8M08_08715	COG3237	CsbD-like
K8M08_08735	COG0596	Alpha beta hydrolase
K8M08_08740	COG0577	efflux transmembrane transporter activity
K8M08_08745	COG1136	(ABC) transporter
K8M08_08800	COG2770	Histidine kinase
K8M08_08800	COG3437	response regulator, receiver
K8M08_08825	COG1959	2 iron, 2 sulfur cluster binding
K8M08_08835	COG2376	Dihydroxyacetone kinase
K8M08_08845	COG2376	Dihydroxyacetone kinase
K8M08_08865	COG1183	phosphatidylcholine synthase activity
K8M08_08940	COG0477	Major facilitator Superfamily
K8M08_08980	COG0305	Participates in initiation and elongation during chromosome replication
K8M08_09000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K8M08_09035	COG0494	nUDIX hydrolase
K8M08_09040	COG3181	Tripartite tricarboxylate transporter family receptor
K8M08_09045	COG4565	transcriptional regulatory protein
K8M08_09050	COG3290	protein histidine kinase activity
K8M08_09055	COG0477	Major facilitator Superfamily
K8M08_09070	COG3409	Peptidoglycan-binding domain 1 protein
K8M08_09075	COG1396	sequence-specific DNA binding
K8M08_09095	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8M08_09125	COG3409	Peptidoglycan-binding domain 1 protein
K8M08_09150	COG0305	Participates in initiation and elongation during chromosome replication
K8M08_09205	COG1363	Peptidase, m42
K8M08_09225	COG1024	Enoyl-CoA hydratase
K8M08_09245	COG4196	transglutaminase domain protein
K8M08_09250	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8M08_09260	COG2244	polysaccharide biosynthetic process
K8M08_09265	COG0653	protein targeting
K8M08_09280	COG0659	secondary active sulfate transmembrane transporter activity
K8M08_09300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8M08_09305	COG3409	Peptidoglycan-binding domain 1 protein
K8M08_09305	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8M08_09315	COG0561	phosphatase activity
K8M08_09330	COG3527	Alpha-acetolactate decarboxylase
K8M08_09335	COG0028	Belongs to the TPP enzyme family
K8M08_09365	COG0189	ligase activity
K8M08_09380	COG1126	abc transporter atp-binding protein
K8M08_09385	COG0765	amino acid transport
K8M08_09390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8M08_09395	COG1132	(ABC) transporter
K8M08_09400	COG1132	(ABC) transporter
K8M08_09405	COG1012	belongs to the aldehyde dehydrogenase family
K8M08_09415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K8M08_09420	COG0531	amino acid
K8M08_09430	COG0753	catalase activity
K8M08_09435	COG0693	protein deglycase activity
K8M08_09445	COG2211	Major facilitator Superfamily
K8M08_09450	COG4533	DNA binding
K8M08_09455	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8M08_09465	COG1733	regulation of RNA biosynthetic process
K8M08_09470	COG2814	Major facilitator Superfamily
K8M08_09475	COG1309	transcriptional regulator
K8M08_09480	COG2076	Multidrug Resistance protein
K8M08_09495	COG0300	oxidoreductase activity
K8M08_09505	COG1522	sequence-specific DNA binding
K8M08_09525	COG2259	Doxx family
K8M08_09535	COG1263	PTS System
K8M08_09535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8M08_09545	COG1737	Transcriptional regulator
K8M08_09555	COG0475	glutathione-regulated potassium exporter activity
K8M08_09560	COG0531	amino acid
K8M08_09595	COG0586	Pfam SNARE associated Golgi protein
K8M08_09630	COG3546	catalase activity
K8M08_09635	COG1114	Component of the transport system for branched-chain amino acids
K8M08_09650	COG5522	Integral membrane protein (intg_mem_TP0381)
K8M08_09655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8M08_09660	COG1136	(ABC) transporter
K8M08_09665	COG0577	efflux transmembrane transporter activity
K8M08_09670	COG3584	3D domain protein
K8M08_09670	COG1388	LysM domain
K8M08_09695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8M08_09700	COG1447	Phosphotransferase system cellobiose-specific component IIA
K8M08_09705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8M08_09705	COG3711	transcriptional antiterminator
K8M08_09715	COG2814	Major facilitator Superfamily
K8M08_09720	COG1283	sodium-dependent phosphate transmembrane transporter activity
K8M08_09725	COG0604	alcohol dehydrogenase
K8M08_09730	COG1316	TRANSCRIPTIONal
K8M08_09740	COG0730	response to heat
K8M08_09745	COG2210	Belongs to the sulfur carrier protein TusA family
K8M08_09755	COG0425	Belongs to the sulfur carrier protein TusA family
K8M08_09755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8M08_09765	COG0425	Belongs to the sulfur carrier protein TusA family
K8M08_09770	COG0425	Belongs to the sulfur carrier protein TusA family
K8M08_09775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8M08_09775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_09780	COG0425	Belongs to the sulfur carrier protein TusA family
K8M08_09780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8M08_09785	COG1937	Protein conserved in bacteria
K8M08_09790	COG0446	pyridine nucleotide-disulphide oxidoreductase
K8M08_09800	COG2719	SpoVR family
K8M08_09805	COG0778	Nitroreductase
K8M08_09845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8M08_09865	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_09870	COG2252	PERMEase
K8M08_09885	COG1846	Transcriptional regulator
K8M08_09890	COG2814	Major facilitator Superfamily
K8M08_09895	COG2205	protein histidine kinase activity
K8M08_09935	COG0351	phosphomethylpyrimidine kinase
K8M08_09940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8M08_09950	COG2104	thiamine diphosphate biosynthetic process
K8M08_09955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8M08_09960	COG0352	thiamine-phosphate diphosphorylase activity
K8M08_09965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K8M08_09970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K8M08_09975	COG1116	anion transmembrane transporter activity
K8M08_09980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K8M08_10000	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K8M08_10120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8M08_10130	COG0581	inorganic phosphate transmembrane transporter activity
K8M08_10135	COG0573	inorganic phosphate transmembrane transporter activity
K8M08_10140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K8M08_10145	COG1918	ferrous iron import across plasma membrane
K8M08_10145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K8M08_10150	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K8M08_10155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K8M08_10170	COG0531	amino acid
K8M08_10175	COG0697	spore germination
K8M08_10180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8M08_10195	COG4990	cell redox homeostasis
K8M08_10200	COG0833	amino acid
K8M08_10205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K8M08_10210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K8M08_10225	COG0569	domain protein
K8M08_10225	COG0475	glutathione-regulated potassium exporter activity
K8M08_10235	COG2153	protein acetylation
K8M08_10250	COG2252	PERMEase
K8M08_10255	COG1113	amino acid transport
K8M08_10270	COG1114	Component of the transport system for branched-chain amino acids
K8M08_10275	COG3104	oligopeptide transport
K8M08_10290	COG1476	TRANSCRIPTIONal
K8M08_10295	COG3583	domain protein
K8M08_10295	COG3584	3D domain protein
K8M08_10300	COG0840	transmembrane signaling receptor activity
K8M08_10330	COG3568	Endonuclease Exonuclease Phosphatase
K8M08_10345	COG1063	alcohol dehydrogenase
K8M08_10365	COG1879	ABC-type sugar transport system periplasmic component
K8M08_10370	COG1172	Belongs to the binding-protein-dependent transport system permease family
K8M08_10385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8M08_10390	COG1609	Transcriptional regulator
K8M08_10395	COG0477	Major facilitator Superfamily
K8M08_10400	COG1846	Transcriptional regulator
K8M08_10405	COG2271	Major facilitator Superfamily
K8M08_10415	COG4608	Belongs to the ABC transporter superfamily
K8M08_10420	COG0601	transmembrane transport
K8M08_10445	COG0659	secondary active sulfate transmembrane transporter activity
K8M08_10460	COG5002	protein histidine kinase activity
K8M08_10465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K8M08_10470	COG2378	regulation of single-species biofilm formation
K8M08_10480	COG1595	DNA-templated transcription, initiation
K8M08_10495	COG0833	amino acid
K8M08_10500	COG0765	amino acid transport
K8M08_10505	COG0765	amino acid transport
K8M08_10510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8M08_10515	COG1126	abc transporter atp-binding protein
K8M08_10520	COG1115	amino acid carrier protein
K8M08_10525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8M08_10530	COG0697	spore germination
K8M08_10545	COG0366	Alpha amylase catalytic
K8M08_10550	COG1263	PTS System
K8M08_10550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8M08_10555	COG2188	Transcriptional regulator
K8M08_10560	COG0531	amino acid
K8M08_10580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8M08_10585	COG0714	Associated with various cellular activities
K8M08_10590	COG4548	von Willebrand factor, type A
K8M08_10600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K8M08_10605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8M08_10610	COG0156	8-amino-7-oxononanoate synthase activity
K8M08_10615	COG2226	methyltransferase
K8M08_10625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_10630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_10635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_10640	COG3104	oligopeptide transport
K8M08_10655	COG1620	l-lactate permease
K8M08_10660	COG1027	Aspartate ammonia-lyase
K8M08_10665	COG1253	flavin adenine dinucleotide binding
K8M08_10670	COG0346	lactoylglutathione lyase activity
K8M08_10675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8M08_10680	COG1316	TRANSCRIPTIONal
K8M08_10685	COG2720	vancomycin resistance protein
K8M08_10705	COG3227	Zinc metalloprotease (Elastase)
K8M08_10720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K8M08_10725	COG2217	Heavy metal translocating P-type atpase
K8M08_10730	COG0640	Transcriptional regulator
K8M08_10735	COG0531	amino acid
K8M08_10750	COG2427	Protein of unknown function (DUF1641)
K8M08_10755	COG3383	formate dehydrogenase (NAD+) activity
K8M08_10760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K8M08_10765	COG0456	acetyltransferase
K8M08_10765	COG0454	-acetyltransferase
K8M08_10770	COG0745	RESPONSE REGULATOR receiver
K8M08_10775	COG5002	protein histidine kinase activity
K8M08_10785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_10790	COG0697	spore germination
K8M08_10800	COG0281	malic enzyme
K8M08_10805	COG3493	citrate carrier protein
K8M08_10810	COG4565	transcriptional regulatory protein
K8M08_10815	COG3290	protein histidine kinase activity
K8M08_10825	COG4990	cell redox homeostasis
K8M08_10835	COG5002	protein histidine kinase activity
K8M08_10840	COG0745	RESPONSE REGULATOR receiver
K8M08_10865	COG2851	Citrate transporter
K8M08_10870	COG4565	transcriptional regulatory protein
K8M08_10875	COG3290	protein histidine kinase activity
K8M08_10885	COG2268	Band 7 protein
K8M08_10890	COG1585	Membrane protein implicated in regulation of membrane protease activity
K8M08_10900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K8M08_10920	COG2766	serine protein kinase
K8M08_10930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K8M08_10940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K8M08_10955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K8M08_10960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K8M08_11075	COG0735	belongs to the Fur family
K8M08_11080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K8M08_11100	COG4555	ABC transporter
K8M08_11110	COG0070	glutamate synthase
K8M08_11110	COG0069	glutamate synthase activity
K8M08_11110	COG0067	glutamate synthase
K8M08_11115	COG4129	membrane
K8M08_11120	COG1132	(ABC) transporter
K8M08_11145	COG1194	a g-specific adenine glycosylase
K8M08_11150	COG1988	membrane-bound metal-dependent
K8M08_11180	COG1090	epimerase
K8M08_11185	COG0402	S-adenosylhomocysteine deaminase activity
K8M08_11205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K8M08_11220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K8M08_11220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8M08_11230	COG0463	Glycosyl transferase, family 2
K8M08_11250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8M08_11255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8M08_11255	COG1263	PTS System
K8M08_11285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8M08_11290	COG0833	amino acid
K8M08_11300	COG3829	transcription factor binding
K8M08_11320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K8M08_11340	COG0535	radical SAM domain protein
K8M08_11350	COG0387	Pfam Sodium calcium exchanger
K8M08_11355	COG3871	stress protein (general stress protein 26)
K8M08_11370	COG0586	Pfam SNARE associated Golgi protein
K8M08_11380	COG0681	Belongs to the peptidase S26 family
K8M08_11390	COG0697	spore germination
K8M08_11395	COG2217	Heavy metal translocating P-type atpase
K8M08_11400	COG1295	ribonuclease BN
K8M08_11410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K8M08_11425	COG3853	Toxic anion resistance protein (TelA)
K8M08_11435	COG0861	Integral membrane protein TerC family
K8M08_11440	COG2310	stress, protein
K8M08_11445	COG2310	stress, protein
K8M08_11450	COG2310	stress, protein
K8M08_11480	COG2270	Major facilitator Superfamily
K8M08_11525	COG0488	(ABC) transporter
K8M08_11535	COG1116	anion transmembrane transporter activity
K8M08_11545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K8M08_11560	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K8M08_11590	COG1263	PTS System
K8M08_11590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8M08_11590	COG2190	(PTS) system
K8M08_11595	COG0366	Alpha amylase catalytic
K8M08_11600	COG0277	FAD linked oxidase domain protein
K8M08_11610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8M08_11615	COG0549	Belongs to the carbamate kinase family
K8M08_11640	COG0840	transmembrane signaling receptor activity
K8M08_11650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8M08_11655	COG0765	amino acid transport
K8M08_11665	COG0723	plastoquinol--plastocyanin reductase activity
K8M08_11665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8M08_11670	COG2814	Major facilitator Superfamily
K8M08_11675	COG3541	Predicted nucleotidyltransferase
K8M08_11720	COG0166	Belongs to the GPI family
K8M08_11735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_11740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_11745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_11755	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K8M08_11765	COG0450	alkyl hydroperoxide reductase
K8M08_11780	COG1473	amidohydrolase
K8M08_11785	COG1757	Na H antiporter
K8M08_11810	COG4807	Protein conserved in bacteria
K8M08_11815	COG5002	protein histidine kinase activity
K8M08_11820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8M08_11825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8M08_11830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8M08_11845	COG2309	aminopeptidase activity
K8M08_11850	COG2076	Multidrug Resistance protein
K8M08_11855	COG1012	belongs to the aldehyde dehydrogenase family
K8M08_11865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K8M08_11870	COG0546	phosphoglycolate phosphatase activity
K8M08_11875	COG1597	lipid kinase activity
K8M08_11895	COG4682	membrane
K8M08_11900	COG1846	Transcriptional regulator
K8M08_11905	COG0003	Pfam Anion-transporting ATPase
K8M08_11920	COG1464	Belongs to the NlpA lipoprotein family
K8M08_11925	COG2011	ABC-type metal ion transport system permease component
K8M08_11935	COG1335	isochorismatase
K8M08_11955	COG4851	CamS sex pheromone cAM373 precursor
K8M08_11965	COG0210	DNA helicase
K8M08_11990	COG0151	Belongs to the GarS family
K8M08_12000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K8M08_12010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K8M08_12025	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K8M08_12035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K8M08_12040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K8M08_12045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K8M08_12070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K8M08_12095	COG5002	protein histidine kinase activity
K8M08_12105	COG2252	PERMEase
K8M08_12115	COG0459	protein refolding
K8M08_12125	COG1266	CAAX protease self-immunity
K8M08_12140	COG0488	(ABC) transporter
K8M08_12150	COG0456	acetyltransferase
K8M08_12155	COG1214	PFAM Peptidase M22, glycoprotease
K8M08_12160	COG0802	atpase or kinase
K8M08_12255	COG2183	response to ionizing radiation
K8M08_12260	COG2337	Toxic component of a toxin-antitoxin (TA) module
K8M08_12265	COG0864	Transcriptional regulator
K8M08_12270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8M08_12275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K8M08_12285	COG0705	Rhomboid family
K8M08_12290	COG4294	response to UV
K8M08_12300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K8M08_12310	COG2814	Major facilitator Superfamily
K8M08_12315	COG0531	amino acid
K8M08_12325	COG0179	Fumarylacetoacetate (FAA) hydrolase
K8M08_12330	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K8M08_12360	COG0561	phosphatase activity
K8M08_12365	COG4608	Belongs to the ABC transporter superfamily
K8M08_12370	COG0444	Belongs to the ABC transporter superfamily
K8M08_12375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8M08_12380	COG0601	transmembrane transport
K8M08_12385	COG0747	negative chemotaxis
K8M08_12390	COG0747	negative chemotaxis
K8M08_12400	COG0842	Transport permease protein
K8M08_12405	COG0842	Transport permease protein
K8M08_12405	COG1511	domain protein
K8M08_12410	COG1131	(ABC) transporter
K8M08_12415	COG2197	response regulator
K8M08_12420	COG4585	Histidine kinase
K8M08_12425	COG0488	(ABC) transporter
K8M08_12450	COG5298	Protein conserved in bacteria
K8M08_12460	COG0084	hydrolase, TatD family'
K8M08_12470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_12480	COG1609	Transcriptional regulator
K8M08_12490	COG0204	Acyl-transferase
K8M08_12505	COG0697	spore germination
K8M08_12520	COG1910	domain protein
K8M08_12525	COG0725	ABC transporter, periplasmic molybdate-binding protein
K8M08_12530	COG4149	molybdate abc transporter
K8M08_12545	COG0656	L-ascorbic acid biosynthetic process
K8M08_12550	COG4166	transmembrane transport
K8M08_12555	COG4166	transmembrane transport
K8M08_12570	COG4166	transmembrane transport
K8M08_12575	COG4608	Belongs to the ABC transporter superfamily
K8M08_12580	COG0444	Belongs to the ABC transporter superfamily
K8M08_12585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8M08_12590	COG0601	transmembrane transport
K8M08_12610	COG2814	Major facilitator Superfamily
K8M08_12620	COG2271	Major facilitator Superfamily
K8M08_12625	COG0277	FAD linked oxidase domain protein
K8M08_12640	COG1464	Belongs to the NlpA lipoprotein family
K8M08_12645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K8M08_12650	COG2011	ABC-type metal ion transport system permease component
K8M08_12655	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_12680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K8M08_12700	COG0596	Alpha beta hydrolase
K8M08_12705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K8M08_12720	COG4856	YbbR-like protein
K8M08_12725	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K8M08_12805	COG0726	polysaccharide deacetylase
K8M08_12810	COG2194	sulfuric ester hydrolase activity
K8M08_12820	COG0489	protein tyrosine kinase activity
K8M08_12825	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8M08_12850	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K8M08_12885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K8M08_12895	COG0024	Methionine aminopeptidase
K8M08_12905	COG0201	protein transport
K8M08_12965	COG0255	Belongs to the universal ribosomal protein uL29 family
K8M08_13035	COG1358	cellular component organization or biogenesis
K8M08_13050	COG2813	Specifically methylates the guanine in position
K8M08_13070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K8M08_13075	COG0250	Participates in transcription elongation, termination and antitermination
K8M08_13080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K8M08_13095	COG3688	RNA-binding protein containing a PIN domain
K8M08_13100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8M08_13115	COG1045	serine acetyltransferase
K8M08_13125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K8M08_13135	COG4956	integral membrane protein (PIN domain superfamily)
K8M08_13145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K8M08_13150	COG0542	response to heat
K8M08_13160	COG3880	PFAM UvrB UvrC protein
K8M08_13250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8M08_13255	COG1396	sequence-specific DNA binding
K8M08_13260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K8M08_13265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K8M08_13270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K8M08_13275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8M08_13280	COG0512	Glutamine amidotransferase of anthranilate synthase
K8M08_13285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K8M08_13290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8M08_13305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K8M08_13310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K8M08_13320	COG2208	phosphoserine phosphatase activity
K8M08_13335	COG1098	S1 RNA binding domain
K8M08_13355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K8M08_13360	COG3956	TIGRFAM MazG family protein
K8M08_13365	COG2244	polysaccharide biosynthetic process
K8M08_13370	COG2002	toxin-antitoxin pair type II binding
K8M08_13375	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K8M08_13405	COG0251	oxidation-reduction process
K8M08_13410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8M08_13425	COG4466	Protein conserved in bacteria
K8M08_13440	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K8M08_13445	COG0084	hydrolase, TatD family'
K8M08_13455	COG2002	toxin-antitoxin pair type II binding
K8M08_13460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K8M08_13470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K8M08_13480	COG1774	PSP1 C-terminal conserved region
K8M08_13495	COG1982	Orn Lys Arg decarboxylase major
K8M08_13550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K8M08_13560	COG0590	tRNA wobble adenosine to inosine editing
K8M08_13565	COG1335	isochorismatase
K8M08_13570	COG1428	Deoxynucleoside kinase
K8M08_13575	COG1428	Deoxynucleoside kinase
K8M08_13605	COG1686	Belongs to the peptidase S11 family
K8M08_13610	COG0516	GMP reductase activity
K8M08_13610	COG0517	IMP dehydrogenase activity
K8M08_13645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K8M08_13650	COG0187	DNA topoisomerase II activity
K8M08_13660	COG2501	S4 domain
K8M08_13665	COG0592	DNA-directed DNA polymerase activity
K8M08_13675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K8M08_13685	COG0706	membrane insertase activity
K8M08_13690	COG1847	R3H domain protein
K8M08_13715	COG1192	Involved in chromosome partitioning
K8M08_13720	COG1475	DNA binding
K8M08_13730	COG0668	transmembrane transport
K8M08_13735	COG4481	Protein conserved in bacteria
K8M08_13740	COG0012	GTP binding
K8M08_13750	COG0629	single-stranded DNA binding
K8M08_13760	COG4241	membrane
K8M08_13765	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K8M08_13775	COG0305	Participates in initiation and elongation during chromosome replication
K8M08_13805	COG0745	RESPONSE REGULATOR receiver
K8M08_13810	COG5002	protein histidine kinase activity
K8M08_13815	COG4863	YycH protein
K8M08_13820	COG4853	Protein conserved in bacteria
K8M08_13825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K8M08_13830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8M08_13850	COG1164	Oligoendopeptidase f
K8M08_13875	COG1272	protein, Hemolysin III
K8M08_13880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K8M08_13900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K8M08_13905	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K8M08_13910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K8M08_13915	COG2814	Major facilitator Superfamily
K8M08_13920	COG3275	phosphorelay sensor kinase activity
K8M08_13925	COG3279	Response regulator of the LytR AlgR family
K8M08_13940	COG0628	permease
K8M08_13945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8M08_13945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8M08_13950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8M08_13955	COG1309	transcriptional regulator
K8M08_13960	COG0463	Glycosyl transferase, family 2
K8M08_13980	COG0488	(ABC) transporter
K8M08_13995	COG1607	acyl-coa hydrolase
K8M08_14005	COG0840	transmembrane signaling receptor activity
K8M08_14030	COG0477	Major facilitator Superfamily
K8M08_14035	COG3279	Response regulator of the LytR AlgR family
K8M08_14040	COG1966	Carbon starvation protein
K8M08_14045	COG2879	small protein
K8M08_14050	COG3706	GGDEF domain
K8M08_14055	COG0351	phosphomethylpyrimidine kinase
K8M08_14060	COG4585	Histidine kinase
K8M08_14060	COG2203	Gaf domain
K8M08_14065	COG2197	response regulator
K8M08_14075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8M08_14080	COG1011	Hydrolase
K8M08_14090	COG2873	o-acetylhomoserine
K8M08_14100	COG0460	homoserine dehydrogenase
K8M08_14110	COG1609	Transcriptional regulator
K8M08_14115	COG2755	lipolytic protein G-D-S-L family
K8M08_14120	COG1131	(ABC) transporter
K8M08_14125	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K8M08_14135	COG2814	Major facilitator Superfamily
K8M08_14140	COG0561	phosphatase activity
K8M08_14145	COG2233	PERMEase
K8M08_14150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8M08_14160	COG2363	Small membrane protein
K8M08_14170	COG3773	Cell wall hydrolase
K8M08_14185	COG0280	phosphate acetyltransferase
K8M08_14210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_14215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_14220	COG1120	ATPase activity
K8M08_14225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_14230	COG1078	dGTPase activity
K8M08_14240	COG1994	Peptidase M50
K8M08_14250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8M08_14255	COG0584	glycerophosphoryl diester phosphodiesterase
K8M08_14260	COG0789	Transcriptional regulator
K8M08_14265	COG2814	Major facilitator Superfamily
K8M08_14290	COG1619	proteins homologs of microcin C7 resistance protein MccF
K8M08_14295	COG4506	Protein conserved in bacteria
K8M08_14305	COG1595	DNA-templated transcription, initiation
K8M08_14330	COG2234	aminopeptidase activity
K8M08_14335	COG0024	Methionine aminopeptidase
K8M08_14340	COG1131	(ABC) transporter
K8M08_14345	COG0842	Transport permease protein
K8M08_14350	COG4585	Histidine kinase
K8M08_14355	COG2197	response regulator
K8M08_14375	COG5001	Diguanylate cyclase
K8M08_14375	COG3300	MHYT domain
K8M08_14385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8M08_14390	COG0247	lactate metabolic process
K8M08_14390	COG2181	nitrate reductase activity
K8M08_14395	COG0183	Belongs to the thiolase family
K8M08_14400	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8M08_14405	COG1960	acyl-CoA dehydrogenase activity
K8M08_14410	COG1960	acyl-CoA dehydrogenase activity
K8M08_14430	COG4821	SIS domain
K8M08_14450	COG1494	fructose-1,6-bisphosphatase
K8M08_14455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K8M08_14475	COG2890	protein-(glutamine-N5) methyltransferase activity
K8M08_14490	COG0009	L-threonylcarbamoyladenylate synthase
K8M08_14505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K8M08_14510	COG2259	Doxx family
K8M08_14515	COG2190	(PTS) system
K8M08_14525	COG0698	ribose 5-phosphate isomerase
K8M08_14560	COG0356	it plays a direct role in the translocation of protons across the membrane
K8M08_14610	COG3300	MHYT domain
K8M08_14610	COG5001	Diguanylate cyclase
K8M08_14625	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8M08_14645	COG0839	Belongs to the complex I subunit 6 family
K8M08_14655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K8M08_14660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K8M08_14665	COG1007	ATP synthesis coupled electron transport
K8M08_14670	COG4836	Membrane
K8M08_14685	COG2385	sporulation resulting in formation of a cellular spore
K8M08_14690	COG3279	Response regulator of the LytR AlgR family
K8M08_14705	COG0739	heme binding
K8M08_14715	COG1609	Transcriptional regulator
K8M08_14725	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K8M08_14730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8M08_14735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8M08_14750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8M08_14755	COG1682	transport, permease protein
K8M08_14760	COG1134	teichoic acid transport
K8M08_14765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8M08_14790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K8M08_14795	COG0745	RESPONSE REGULATOR receiver
K8M08_14800	COG5002	protein histidine kinase activity
K8M08_14825	COG1136	(ABC) transporter
K8M08_14830	COG0577	efflux transmembrane transporter activity
K8M08_14870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K8M08_14875	COG4715	Zinc finger, swim domain protein
K8M08_14900	COG1388	LysM domain
K8M08_14900	COG3584	3D domain protein
K8M08_14905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K8M08_14910	COG1215	transferase activity, transferring glycosyl groups
K8M08_14920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8M08_14925	COG0791	NLP P60 protein
K8M08_14925	COG1388	LysM domain
K8M08_14935	COG1368	sulfuric ester hydrolase activity
K8M08_14945	COG2389	metal-binding protein
K8M08_14955	COG1620	l-lactate permease
K8M08_14965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K8M08_14970	COG1294	oxidase, subunit
K8M08_14975	COG1271	oxidase subunit
K8M08_14985	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K8M08_14990	COG0583	DNA-binding transcription factor activity
K8M08_14995	COG1511	domain protein
K8M08_15000	COG0346	lactoylglutathione lyase activity
K8M08_15010	COG1301	dicarboxylic acid transport
K8M08_15015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8M08_15025	COG1447	Phosphotransferase system cellobiose-specific component IIA
K8M08_15045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8M08_15050	COG1447	Phosphotransferase system cellobiose-specific component IIA
K8M08_15055	COG1486	melibiose metabolic process
K8M08_15075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K8M08_15075	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K8M08_15085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8M08_15090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K8M08_15095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8M08_15100	COG1316	TRANSCRIPTIONal
K8M08_15105	COG1739	Uncharacterized protein family UPF0029
K8M08_15110	COG1307	EDD domain protein, DegV family
K8M08_15115	COG1733	regulation of RNA biosynthetic process
K8M08_15120	COG1388	LysM domain
K8M08_15120	COG0791	NLP P60 protein
K8M08_15125	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K8M08_15130	COG1040	competence protein
K8M08_15135	COG1278	Cold shock
K8M08_15140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K8M08_15160	COG2884	Cell division ATP-binding protein ftsE
K8M08_15165	COG2177	Part of the ABC transporter FtsEX involved in
K8M08_15170	COG0793	Belongs to the peptidase S41A family
K8M08_15170	COG3409	Peptidoglycan-binding domain 1 protein
K8M08_15175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8M08_15180	COG1132	(ABC) transporter
K8M08_15190	COG0488	(ABC) transporter
K8M08_15195	COG0655	NAD(P)H dehydrogenase (quinone) activity
K8M08_15205	COG0583	DNA-binding transcription factor activity
K8M08_15225	COG0789	Transcriptional regulator
K8M08_15240	COG0556	nucleotide-excision repair
K8M08_15245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K8M08_15255	COG1950	PFAM Membrane protein of
K8M08_15275	COG0110	maltose O-acetyltransferase activity
K8M08_15280	COG0457	Tetratricopeptide repeat
K8M08_15285	COG0492	ferredoxin-NADP+ reductase activity
K8M08_15295	COG1051	belongs to the nudix hydrolase family
K8M08_15305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K8M08_15315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8M08_15325	COG2323	membrane
K8M08_15340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8M08_15365	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K8M08_15380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K8M08_15415	COG1346	cytolysis
K8M08_15420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K8M08_15425	COG1647	Serine aminopeptidase, S33
K8M08_15430	COG0557	exoribonuclease II activity
K8M08_15475	COG1136	(ABC) transporter
K8M08_15495	COG1136	(ABC) transporter
K8M08_15500	COG0745	RESPONSE REGULATOR receiver
K8M08_15505	COG5002	protein histidine kinase activity
K8M08_15570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_15590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K8M08_15600	COG3290	protein histidine kinase activity
K8M08_15600	COG0840	transmembrane signaling receptor activity
K8M08_15615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8M08_15620	COG1252	NADH dehydrogenase
K8M08_15630	COG1733	regulation of RNA biosynthetic process
K8M08_15635	COG2814	Major facilitator Superfamily
K8M08_15640	COG0656	L-ascorbic acid biosynthetic process
K8M08_15655	COG2910	NAD(P)H-binding
K8M08_15660	COG1115	amino acid carrier protein
K8M08_15665	COG1115	amino acid carrier protein
K8M08_15670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8M08_15675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8M08_15695	COG1611	Belongs to the LOG family
K8M08_15710	COG0783	Belongs to the Dps family
K8M08_15715	COG1115	amino acid carrier protein
K8M08_15720	COG0490	domain, Protein
K8M08_15725	COG0475	glutathione-regulated potassium exporter activity
K8M08_15730	COG0586	Pfam SNARE associated Golgi protein
K8M08_15745	COG1741	Belongs to the pirin family
K8M08_15750	COG3227	Zinc metalloprotease (Elastase)
K8M08_15755	COG2151	metal-sulfur cluster biosynthetic enzyme
K8M08_15760	COG0840	transmembrane signaling receptor activity
K8M08_15785	COG5002	protein histidine kinase activity
K8M08_15790	COG0745	RESPONSE REGULATOR receiver
K8M08_15795	COG1376	ErfK ybiS ycfS ynhG family protein
K8M08_15805	COG0586	Pfam SNARE associated Golgi protein
K8M08_15840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_15865	COG0531	amino acid
K8M08_15870	COG2814	Major facilitator Superfamily
K8M08_15890	COG0840	transmembrane signaling receptor activity
K8M08_15895	COG0011	TIGRFAM Protein of
K8M08_15910	COG1686	Belongs to the peptidase S11 family
K8M08_15920	COG1024	Enoyl-CoA hydratase
K8M08_15920	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8M08_15925	COG0183	Belongs to the thiolase family
K8M08_15930	COG1960	acyl-CoA dehydrogenase activity
K8M08_15935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_15940	COG1309	transcriptional regulator
K8M08_16015	COG1393	Belongs to the ArsC family
K8M08_16030	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K8M08_16035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8M08_16045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K8M08_16050	COG2011	ABC-type metal ion transport system permease component
K8M08_16055	COG1464	Belongs to the NlpA lipoprotein family
K8M08_16060	COG1464	Belongs to the NlpA lipoprotein family
K8M08_16065	COG0396	ATPase activity
K8M08_16070	COG0719	Fe-S assembly protein
K8M08_16075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K8M08_16080	COG0822	iron-sulfur transferase activity
K8M08_16085	COG0719	Fe-S assembly protein
K8M08_16095	COG1695	Transcriptional regulator
K8M08_16100	COG0737	Belongs to the 5'-nucleotidase family
K8M08_16105	COG3377	Domain of unknown function (DUF1805)
K8M08_16115	COG0739	heme binding
K8M08_16140	COG4377	Putative membrane peptidase family (DUF2324)
K8M08_16145	COG0789	Transcriptional regulator
K8M08_16155	COG4470	Protein conserved in bacteria
K8M08_16170	COG1494	fructose-1,6-bisphosphatase
K8M08_16175	COG2445	Protein of unknown function DUF86
K8M08_16185	COG0647	UMP catabolic process
K8M08_16190	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8M08_16200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K8M08_16205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8M08_16215	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K8M08_16220	COG4837	Protein of unknown function (DUF1462)
K8M08_16240	COG2824	Alkylphosphonate utilization operon protein PhnA
K8M08_16245	COG0390	transport system, permease component
K8M08_16260	COG1252	NADH dehydrogenase
K8M08_16275	COG0316	Belongs to the HesB IscA family
K8M08_16300	COG1683	Conserved Protein
K8M08_16315	COG3708	Transcriptional regulator
K8M08_16325	COG1252	NADH dehydrogenase
K8M08_16340	COG3584	3D domain protein
K8M08_16355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8M08_16360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8M08_16365	COG1268	BioY protein
K8M08_16375	COG2050	protein possibly involved in aromatic compounds catabolism
K8M08_16395	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K8M08_16400	COG5018	Exonuclease
K8M08_16420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K8M08_16430	COG2267	carboxylic ester hydrolase activity
K8M08_16435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8M08_16440	COG1522	sequence-specific DNA binding
K8M08_16445	COG0436	Aminotransferase
K8M08_16450	COG1098	S1 RNA binding domain
K8M08_16455	COG2155	Conserved Protein
K8M08_16470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8M08_16475	COG1285	pathogenesis
K8M08_16510	COG0544	peptidyl-prolyl cis-trans isomerase activity
K8M08_16605	COG1595	DNA-templated transcription, initiation
K8M08_16620	COG1404	Belongs to the peptidase S8 family
K8M08_16640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K8M08_16650	COG0058	SHG alpha-glucan phosphorylase activity
K8M08_16675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K8M08_16680	COG1575	Belongs to the MenA family. Type 1 subfamily
K8M08_16685	COG1169	isochorismate synthase
K8M08_16695	COG0596	Alpha beta hydrolase
K8M08_16700	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K8M08_16710	COG4948	Mandelate Racemase Muconate Lactonizing
K8M08_16730	COG3964	amidohydrolase
K8M08_16750	COG2188	Transcriptional regulator
K8M08_16775	COG0577	efflux transmembrane transporter activity
K8M08_16780	COG1136	(ABC) transporter
K8M08_16785	COG0577	efflux transmembrane transporter activity
K8M08_16790	COG0577	efflux transmembrane transporter activity
K8M08_16795	COG2205	protein histidine kinase activity
K8M08_16800	COG0745	RESPONSE REGULATOR receiver
K8M08_16805	COG0640	Transcriptional regulator
K8M08_16810	COG5658	integral membrane protein
K8M08_16815	COG3708	Transcriptional regulator
K8M08_16815	COG2207	Transcriptional regulator
K8M08_16820	COG1136	(ABC) transporter
K8M08_16825	COG0577	efflux transmembrane transporter activity
K8M08_16835	COG4977	sequence-specific DNA binding
K8M08_16845	COG0586	Pfam SNARE associated Golgi protein
K8M08_16885	COG1597	lipid kinase activity
K8M08_16890	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K8M08_16915	COG0745	RESPONSE REGULATOR receiver
K8M08_16920	COG5002	protein histidine kinase activity
K8M08_16965	COG1842	Phage shock protein A
K8M08_16990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_17015	COG1294	oxidase, subunit
K8M08_17020	COG1271	oxidase subunit
K8M08_17025	COG0288	reversible hydration of carbon dioxide
K8M08_17055	COG0494	nUDIX hydrolase
K8M08_17080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K8M08_17085	COG1116	anion transmembrane transporter activity
K8M08_17090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K8M08_17105	COG1368	sulfuric ester hydrolase activity
K8M08_17110	COG2267	carboxylic ester hydrolase activity
K8M08_17115	COG4191	Histidine kinase
K8M08_17120	COG5002	protein histidine kinase activity
K8M08_17190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_17205	COG0521	Mo-molybdopterin cofactor biosynthetic process
K8M08_17215	COG0438	transferase activity, transferring glycosyl groups
K8M08_17220	COG0671	phosphoesterase, PA-phosphatase related
K8M08_17225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K8M08_17230	COG2267	carboxylic ester hydrolase activity
K8M08_17255	COG1794	racemase activity, acting on amino acids and derivatives
K8M08_17270	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K8M08_17275	COG1242	4 iron, 4 sulfur cluster binding
K8M08_17295	COG1136	(ABC) transporter
K8M08_17305	COG0582	viral genome integration into host DNA
K8M08_17310	COG0490	domain, Protein
K8M08_17315	COG0475	glutathione-regulated potassium exporter activity
K8M08_17320	COG2814	Major facilitator Superfamily
K8M08_17360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K8M08_17370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8M08_17390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K8M08_17395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8M08_17405	COG0303	'Molybdopterin
K8M08_17410	COG1763	Mo-molybdopterin cofactor biosynthetic process
K8M08_17415	COG0314	molybdopterin synthase activity
K8M08_17440	COG1329	Transcriptional regulator
K8M08_17460	COG3832	glyoxalase III activity
K8M08_17470	COG2814	Major facilitator Superfamily
K8M08_17475	COG2081	HI0933 family
K8M08_17480	COG2244	polysaccharide biosynthetic process
K8M08_17485	COG1187	pseudouridine synthase activity
K8M08_17490	COG1349	DNA-binding transcription factor activity
K8M08_17495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8M08_17505	COG1523	belongs to the glycosyl hydrolase 13 family
K8M08_17510	COG0510	thiamine kinase activity
K8M08_17525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_17535	COG1363	Peptidase, m42
K8M08_17540	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K8M08_17545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8M08_17555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8M08_17570	COG1674	ftsk spoiiie
K8M08_17590	COG1695	Transcriptional regulator
K8M08_17595	COG0789	Transcriptional regulator
K8M08_17600	COG0697	spore germination
K8M08_17605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_17620	COG2309	aminopeptidase activity
K8M08_17630	COG3118	belongs to the thioredoxin family
K8M08_17635	COG4851	CamS sex pheromone cAM373 precursor
K8M08_17640	COG1609	Transcriptional regulator
K8M08_17675	COG0666	response to abiotic stimulus
K8M08_17680	COG5002	protein histidine kinase activity
K8M08_17685	COG0745	RESPONSE REGULATOR receiver
K8M08_17695	COG2267	carboxylic ester hydrolase activity
K8M08_17700	COG0123	including yeast histone deacetylase and acetoin utilization protein
K8M08_17705	COG0517	IMP dehydrogenase activity
K8M08_17710	COG0454	-acetyltransferase
K8M08_17715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8M08_17730	COG1595	DNA-templated transcription, initiation
K8M08_17760	COG0626	cystathionine gamma-synthase activity
K8M08_17765	COG1956	GAF domain-containing protein
K8M08_17770	COG1309	transcriptional regulator
K8M08_17775	COG0697	spore germination
K8M08_17780	COG0583	DNA-binding transcription factor activity
K8M08_17790	COG1104	cysteine desulfurase activity
K8M08_17805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8M08_17815	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K8M08_17830	COG3874	Sporulation protein YtfJ
K8M08_17835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K8M08_17840	COG0827	DNA restriction-modification system
K8M08_17865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_17900	COG0589	response to stress
K8M08_17905	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_17920	COG1476	TRANSCRIPTIONal
K8M08_17930	COG0662	Cupin 2, conserved barrel domain protein
K8M08_17935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_17975	COG0006	proline dipeptidase activity
K8M08_17990	COG4109	DRTGG domain
K8M08_18000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8M08_18015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K8M08_18030	COG0587	DNA-directed DNA polymerase activity
K8M08_18035	COG0281	malic enzyme
K8M08_18040	COG1725	Transcriptional regulator
K8M08_18065	COG3030	protein affecting phage T7 exclusion by the F plasmid
K8M08_18070	COG0628	permease
K8M08_18080	COG0372	Belongs to the citrate synthase family
K8M08_18085	COG0538	isocitrate dehydrogenase activity
K8M08_18105	COG0745	RESPONSE REGULATOR receiver
K8M08_18110	COG5002	protein histidine kinase activity
K8M08_18115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8M08_18115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8M08_18125	COG1971	Probably functions as a manganese efflux pump
K8M08_18130	COG0237	dephospho-CoA kinase activity
K8M08_18135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K8M08_18140	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K8M08_18150	COG3611	Membrane attachment protein
K8M08_18155	COG1484	DNA-dependent DNA replication
K8M08_18165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K8M08_18190	COG1363	Peptidase, m42
K8M08_18195	COG1309	transcriptional regulator
K8M08_18200	COG1566	PFAM secretion protein HlyD family protein
K8M08_18205	COG2814	Major facilitator Superfamily
K8M08_18215	COG1418	mRNA catabolic process
K8M08_18225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8M08_18270	COG1286	toxin biosynthetic process
K8M08_18275	COG1796	DNA polymerase
K8M08_18275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K8M08_18285	COG1187	pseudouridine synthase activity
K8M08_18290	COG1114	Component of the transport system for branched-chain amino acids
K8M08_18295	COG5386	Cell surface protein
K8M08_18305	COG5386	Cell surface protein
K8M08_18320	COG1120	ATPase activity
K8M08_18325	COG4509	Sortase family
K8M08_18335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8M08_18340	COG4895	conserved protein (DUF2196)
K8M08_18350	COG0745	RESPONSE REGULATOR receiver
K8M08_18355	COG2205	protein histidine kinase activity
K8M08_18360	COG1131	(ABC) transporter
K8M08_18390	COG2318	DinB family
K8M08_18405	COG0318	PFAM AMP-dependent synthetase and ligase
K8M08_18410	COG1309	transcriptional regulator
K8M08_18415	COG1024	Enoyl-CoA hydratase
K8M08_18420	COG2086	electron transfer activity
K8M08_18425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K8M08_18430	COG3118	belongs to the thioredoxin family
K8M08_18440	COG1719	4-vinyl reductase, 4VR
K8M08_18445	COG2009	succinate dehydrogenase
K8M08_18450	COG1053	succinate dehydrogenase
K8M08_18455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K8M08_18460	COG0824	Thioesterase
K8M08_18465	COG1876	peptidase activity
K8M08_18470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8M08_18475	COG1360	Flagellar Motor Protein
K8M08_18480	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K8M08_18485	COG4152	abc transporter atp-binding protein
K8M08_18490	COG1668	transmembrane transport
K8M08_18495	COG1959	2 iron, 2 sulfur cluster binding
K8M08_18505	COG0697	spore germination
K8M08_18510	COG1396	sequence-specific DNA binding
K8M08_18515	COG1983	PspC domain protein
K8M08_18525	COG3279	Response regulator of the LytR AlgR family
K8M08_18530	COG3275	phosphorelay sensor kinase activity
K8M08_18535	COG4608	Belongs to the ABC transporter superfamily
K8M08_18540	COG0444	Belongs to the ABC transporter superfamily
K8M08_18550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8M08_18560	COG0402	S-adenosylhomocysteine deaminase activity
K8M08_18565	COG0402	S-adenosylhomocysteine deaminase activity
K8M08_18575	COG2233	PERMEase
K8M08_18580	COG2197	response regulator
K8M08_18595	COG1309	transcriptional regulator
K8M08_18615	COG5401	PFAM Sporulation and spore germination
K8M08_18630	COG0622	Phosphoesterase
K8M08_18675	COG1067	ATP-dependent peptidase activity
K8M08_18675	COG0470	DNA polymerase III
K8M08_18690	COG1764	response to oxidative stress
K8M08_18695	COG1846	Transcriptional regulator
K8M08_18705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8M08_18715	COG1587	Uroporphyrinogen-III synthase
K8M08_18720	COG0113	porphobilinogen synthase activity
K8M08_18730	COG1388	LysM domain
K8M08_18745	COG0285	dihydrofolate synthase activity
K8M08_18765	COG1077	Cell shape determining protein MreB Mrl
K8M08_18785	COG2894	cell division
K8M08_18790	COG0739	heme binding
K8M08_18795	COG1994	Peptidase M50
K8M08_18800	COG1530	ribonuclease E activity
K8M08_18810	COG2868	ribosomal protein
K8M08_18820	COG3290	protein histidine kinase activity
K8M08_18830	COG0745	RESPONSE REGULATOR receiver
K8M08_18835	COG5002	protein histidine kinase activity
K8M08_18840	COG1136	(ABC) transporter
K8M08_18845	COG0577	efflux transmembrane transporter activity
K8M08_18850	COG0577	efflux transmembrane transporter activity
K8M08_18855	COG0077	Prephenate dehydratase
K8M08_18860	COG2258	MOSC domain
K8M08_18865	COG1827	regulation of RNA biosynthetic process
K8M08_18870	COG1104	cysteine desulfurase activity
K8M08_18875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K8M08_18880	COG0157	Belongs to the NadC ModD family
K8M08_18905	COG0640	Transcriptional regulator
K8M08_18910	COG0697	spore germination
K8M08_18920	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K8M08_18950	COG1862	Preprotein translocase
K8M08_18960	COG2323	membrane
K8M08_18965	COG2244	polysaccharide biosynthetic process
K8M08_18975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8M08_18975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8M08_18980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8M08_18985	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K8M08_18985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K8M08_18995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8M08_19020	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K8M08_19030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K8M08_19035	COG1959	2 iron, 2 sulfur cluster binding
K8M08_19040	COG1104	cysteine desulfurase activity
K8M08_19055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K8M08_19075	COG0628	permease
K8M08_19105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K8M08_19110	COG4122	O-methyltransferase activity
K8M08_19115	COG0826	peptidase U32
K8M08_19120	COG0826	peptidase U32
K8M08_19135	COG0768	penicillin binding
K8M08_19160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8M08_19165	COG0626	cystathionine gamma-synthase activity
K8M08_19170	COG1454	alcohol dehydrogenase
K8M08_19170	COG1012	belongs to the aldehyde dehydrogenase family
K8M08_19180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_19220	COG2259	Doxx family
K8M08_19225	COG2514	catechol 2,3-dioxygenase activity
K8M08_19235	COG3186	Phenylalanine-4-hydroxylase
K8M08_19240	COG1404	Belongs to the peptidase S8 family
K8M08_19275	COG2267	carboxylic ester hydrolase activity
K8M08_19285	COG1785	Belongs to the alkaline phosphatase family
K8M08_19295	COG2357	RelA SpoT domain protein
K8M08_19300	COG0778	Nitroreductase
K8M08_19330	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K8M08_19335	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K8M08_19345	COG1534	Rna-binding protein
K8M08_19360	COG0799	negative regulation of ribosome biogenesis
K8M08_19365	COG2226	methyltransferase
K8M08_19370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8M08_19375	COG1555	photosystem II stabilization
K8M08_19375	COG1596	polysaccharide export
K8M08_19380	COG2131	deaminase
K8M08_19385	COG0658	competence protein
K8M08_19385	COG2333	competence protein COMEC
K8M08_19395	COG1466	dna polymerase III delta subunit
K8M08_19420	COG1733	regulation of RNA biosynthetic process
K8M08_19425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8M08_19455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K8M08_19460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8M08_19465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K8M08_19470	COG1610	YqeY-like protein
K8M08_19485	COG1702	phosphate starvation-inducible protein PhoH
K8M08_19490	COG1480	7TM receptor with intracellular HD hydrolase
K8M08_19500	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K8M08_19505	COG0295	cytidine deaminase activity
K8M08_19510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K8M08_19525	COG0517	IMP dehydrogenase activity
K8M08_19535	COG0358	DNA primase activity
K8M08_19540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8M08_19545	COG2010	Cytochrome c
K8M08_19550	COG2384	SAM-dependent methyltransferase
K8M08_19555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K8M08_19585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_19590	COG1121	(ABC) transporter
K8M08_19595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8M08_19600	COG0735	belongs to the Fur family
K8M08_19630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K8M08_19635	COG0477	Major facilitator Superfamily
K8M08_19640	COG0768	penicillin binding
K8M08_19645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K8M08_19650	COG0573	inorganic phosphate transmembrane transporter activity
K8M08_19655	COG0581	inorganic phosphate transmembrane transporter activity
K8M08_19665	COG0704	Plays a role in the regulation of phosphate uptake
K8M08_19670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K8M08_19675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K8M08_19680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K8M08_19685	COG4483	Protein conserved in bacteria
K8M08_19690	COG1940	carbohydrate kinase activity
K8M08_19700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_19720	COG0626	cystathionine gamma-synthase activity
K8M08_19725	COG0626	cystathionine gamma-synthase activity
K8M08_19730	COG0646	methionine synthase
K8M08_19730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K8M08_19735	COG1410	methionine synthase
K8M08_19735	COG0646	methionine synthase
K8M08_19785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K8M08_19790	COG1459	type II secretion system
K8M08_19800	COG4970	Tfp pilus assembly protein FimT
K8M08_19865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K8M08_19895	COG1725	Transcriptional regulator
K8M08_19935	COG2076	Multidrug Resistance protein
K8M08_19940	COG2076	Multidrug Resistance protein
K8M08_19950	COG1609	Transcriptional regulator
K8M08_19960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8M08_19965	COG0095	Lipoate-protein ligase
K8M08_20000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8M08_20010	COG3872	metal-dependent enzyme
K8M08_20025	COG0006	proline dipeptidase activity
K8M08_20050	COG3854	ATPases associated with a variety of cellular activities
K8M08_20095	COG0511	ligase activity, forming carbon-carbon bonds
K8M08_20100	COG0439	Biotin carboxylase
K8M08_20105	COG1302	Protein conserved in bacteria
K8M08_20130	COG0142	geranyltranstransferase activity
K8M08_20140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K8M08_20150	COG0497	DNA recombination
K8M08_20155	COG0750	zinc metalloprotease
K8M08_20160	COG0745	RESPONSE REGULATOR receiver
K8M08_20170	COG3093	addiction module antidote protein HigA
K8M08_20175	COG0584	glycerophosphoryl diester phosphodiesterase
K8M08_20185	COG3290	protein histidine kinase activity
K8M08_20185	COG3829	transcription factor binding
K8M08_20190	COG0280	phosphate acetyltransferase
K8M08_20205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8M08_20210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8M08_20215	COG0022	dehydrogenase e1 component
K8M08_20220	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8M08_20225	COG0772	Belongs to the SEDS family
K8M08_20230	COG2323	membrane
K8M08_20250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8M08_20255	COG0765	amino acid transport
K8M08_20260	COG1126	abc transporter atp-binding protein
K8M08_20265	COG4129	membrane
K8M08_20270	COG1376	ErfK ybiS ycfS ynhG family protein
K8M08_20285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_20290	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8M08_20315	COG1760	l-serine dehydratase
K8M08_20320	COG1760	l-serine dehydratase
K8M08_20325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8M08_20330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_20335	COG0300	oxidoreductase activity
K8M08_20360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8M08_20380	COG1522	sequence-specific DNA binding
K8M08_20390	COG0737	Belongs to the 5'-nucleotidase family
K8M08_20395	COG1757	Na H antiporter
K8M08_20405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8M08_20420	COG1073	alpha beta
K8M08_20420	COG2226	methyltransferase
K8M08_20425	COG4106	trans-aconitate 2-methyltransferase activity
K8M08_20450	COG0307	riboflavin synthase, alpha
K8M08_20455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8M08_20455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8M08_20470	COG1073	alpha beta
K8M08_20475	COG0456	acetyltransferase
K8M08_20480	COG1609	Transcriptional regulator
K8M08_20485	COG2056	Na+-H+ antiporter family
K8M08_20490	COG0596	Alpha beta hydrolase
K8M08_20500	COG4085	toxin activity
K8M08_20500	COG1525	nuclease
K8M08_20500	COG0737	Belongs to the 5'-nucleotidase family
K8M08_20510	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K8M08_20510	COG0456	acetyltransferase
K8M08_20515	COG0656	L-ascorbic acid biosynthetic process
K8M08_20520	COG0667	Aldo Keto reductase
K8M08_20540	COG1300	Membrane
K8M08_20545	COG0735	belongs to the Fur family
K8M08_20555	COG4974	Belongs to the 'phage' integrase family
K8M08_20580	COG0598	Magnesium transport protein CorA
K8M08_20595	COG1846	Transcriptional regulator
K8M08_20615	COG1131	(ABC) transporter
K8M08_20620	COG1725	Transcriptional regulator
K8M08_20625	COG1686	Belongs to the peptidase S11 family
K8M08_20645	COG0733	neurotransmitter:sodium symporter activity
K8M08_20670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8M08_20685	COG0697	spore germination
K8M08_20690	COG0561	phosphatase activity
K8M08_20695	COG4086	secreted protein
K8M08_20700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K8M08_20710	COG0456	acetyltransferase
K8M08_20715	COG1547	Domain of unknown function (DUF309)
K8M08_20740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K8M08_20750	COG2188	Transcriptional regulator
K8M08_20760	COG3711	transcriptional antiterminator
K8M08_20765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8M08_20765	COG2190	(PTS) system
K8M08_20765	COG1263	PTS System
K8M08_20790	COG0778	Nitroreductase
K8M08_20795	COG2199	diguanylate cyclase activity
K8M08_20805	COG2084	Dehydrogenase
K8M08_20840	COG0436	Aminotransferase
K8M08_20845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8M08_20865	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_20870	COG1695	Transcriptional regulator
K8M08_20905	COG0183	Belongs to the thiolase family
K8M08_20910	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K8M08_20945	COG3842	ATPase activity
K8M08_20950	COG0366	Alpha amylase catalytic
K8M08_20960	COG2182	Extracellular solute-binding protein
K8M08_20965	COG1175	transmembrane transport
K8M08_20970	COG3833	ABC-type maltose transport systems, permease component
K8M08_20975	COG1609	Transcriptional regulator
K8M08_20980	COG0436	Aminotransferase
K8M08_20990	COG2205	protein histidine kinase activity
K8M08_21000	COG3209	COG3209 Rhs family protein
K8M08_21020	COG2814	Major facilitator Superfamily
K8M08_21055	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K8M08_21065	COG1408	metallophosphoesterase
K8M08_21070	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_21075	COG2200	EAL domain
K8M08_21090	COG4703	Protein of unknown function (DUF1797)
K8M08_21100	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K8M08_21110	COG0517	IMP dehydrogenase activity
K8M08_21115	COG0583	DNA-binding transcription factor activity
K8M08_21135	COG0569	domain protein
K8M08_21140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K8M08_21150	COG0561	phosphatase activity
K8M08_21155	COG0242	peptide deformylase activity
K8M08_21165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8M08_21170	COG0022	dehydrogenase e1 component
K8M08_21220	COG1982	Orn Lys Arg decarboxylase major
K8M08_21240	COG0483	inositol monophosphate 1-phosphatase activity
K8M08_21250	COG1217	gtp-binding protein TYPA
K8M08_21265	COG4896	Protein conserved in bacteria
K8M08_21275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K8M08_21280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K8M08_21290	COG0772	Belongs to the SEDS family
K8M08_21295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K8M08_21330	COG3336	cytochrome c oxidase
K8M08_21340	COG2340	Cysteine-rich secretory protein family
K8M08_21355	COG0406	alpha-ribazole phosphatase activity
K8M08_21360	COG3679	Belongs to the UPF0342 family
K8M08_21375	COG0742	ribosomal rna small subunit methyltransferase
K8M08_21385	COG3314	Sporulation integral membrane protein YlbJ
K8M08_21390	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8M08_21395	COG3480	Lon protease (S16) C-terminal proteolytic domain
K8M08_21405	COG1399	metal-binding, possibly nucleic acid-binding protein
K8M08_21410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K8M08_21425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K8M08_21440	COG4839	cell division protein FtsL
K8M08_21445	COG0768	penicillin binding
K8M08_21450	COG0768	penicillin binding
K8M08_21455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K8M08_21470	COG0772	Belongs to the SEDS family
K8M08_21485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K8M08_21490	COG0849	cell division
K8M08_21495	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K8M08_21505	COG1191	sigma factor activity
K8M08_21510	COG1191	sigma factor activity
K8M08_21515	COG1873	PFAM PRC-barrel domain
K8M08_21525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K8M08_21535	COG0762	integral membrane protein
K8M08_21540	COG2302	S4 RNA-binding domain
K8M08_21545	COG3599	regulation of cell shape
K8M08_21565	COG0564	pseudouridine synthase activity
K8M08_21630	COG3069	C4-dicarboxylate transmembrane transporter activity
K8M08_21645	COG0006	proline dipeptidase activity
K8M08_21660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K8M08_21665	COG1561	YicC-like family, N-terminal region
K8M08_21685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K8M08_21690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K8M08_21695	COG0242	peptide deformylase activity
K8M08_21705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K8M08_21705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8M08_21715	COG0631	protein serine/threonine phosphatase activity
K8M08_21720	COG0515	serine threonine protein kinase
K8M08_21720	COG2815	serine threonine protein kinase
K8M08_21730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K8M08_21735	COG1564	THIamine pyrophosphokinase
K8M08_21750	COG1302	Protein conserved in bacteria
K8M08_21755	COG1461	Dihydroxyacetone kinase
K8M08_21760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K8M08_21775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K8M08_21780	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_21785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8M08_21795	COG1196	nuclear chromosome segregation
K8M08_21800	COG0552	protein localization to endoplasmic reticulum
K8M08_21810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K8M08_21820	COG1837	Belongs to the UPF0109 family
K8M08_21860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K8M08_21865	COG0758	DNA mediated transformation
K8M08_21870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8M08_21880	COG4974	Belongs to the 'phage' integrase family
K8M08_21910	COG0528	UMP kinase activity
K8M08_21925	COG4589	Belongs to the CDS family
K8M08_21935	COG0750	zinc metalloprotease
K8M08_21955	COG0195	Participates in both transcription termination and antitermination
K8M08_21960	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K8M08_21965	COG1358	cellular component organization or biogenesis
K8M08_21975	COG1550	Protein conserved in bacteria
K8M08_21990	COG0196	riboflavin kinase activity
K8M08_22005	COG0726	polysaccharide deacetylase
K8M08_22010	COG0612	Peptidase, M16
K8M08_22015	COG1873	PFAM PRC-barrel domain
K8M08_22020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8M08_22025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K8M08_22030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8M08_22035	COG0527	aspartate kinase activity
K8M08_22045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K8M08_22050	COG0740	serine-type endopeptidase activity
K8M08_22060	COG1674	ftsk spoiiie
K8M08_22065	COG2188	Transcriptional regulator
K8M08_22070	COG1744	ABC transporter substrate-binding protein PnrA-like
K8M08_22075	COG3845	ABC transporter
K8M08_22080	COG4603	Belongs to the binding-protein-dependent transport system permease family
K8M08_22085	COG1079	Belongs to the binding-protein-dependent transport system permease family
K8M08_22090	COG0612	Peptidase, M16
K8M08_22095	COG0612	Peptidase, M16
K8M08_22100	COG0300	oxidoreductase activity
K8M08_22115	COG1426	Protein conserved in bacteria
K8M08_22120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K8M08_22145	COG1692	metallophosphoesterase
K8M08_22150	COG2359	stage V sporulation protein S
K8M08_22160	COG0674	pyruvate-flavodoxin oxidoreductase activity
K8M08_22160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K8M08_22165	COG1013	pyruvate-flavodoxin oxidoreductase activity
K8M08_22175	COG4550	Control of competence regulator ComK, YlbF/YmcA
K8M08_22195	COG1131	(ABC) transporter
K8M08_22220	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K8M08_22230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K8M08_22235	COG1368	sulfuric ester hydrolase activity
K8M08_22245	COG3773	Cell wall hydrolase
K8M08_22250	COG1404	Belongs to the peptidase S8 family
K8M08_22270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_22275	COG1380	Effector of murein hydrolase LrgA
K8M08_22280	COG1346	cytolysis
K8M08_22290	COG0384	phenazine biosynthesis protein PhzF
K8M08_22325	COG3300	MHYT domain
K8M08_22325	COG5001	Diguanylate cyclase
K8M08_22345	COG2364	Membrane
K8M08_22355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K8M08_22360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K8M08_22365	COG2169	Transcriptional regulator
K8M08_22370	COG0708	Exodeoxyribonuclease III
K8M08_22375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_22380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_22385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_22390	COG1120	ATPase activity
K8M08_22395	COG2819	hydrolase of the alpha beta superfamily
K8M08_22405	COG1937	Protein conserved in bacteria
K8M08_22410	COG2608	mercury ion transmembrane transporter activity
K8M08_22415	COG2217	Heavy metal translocating P-type atpase
K8M08_22430	COG2116	formate transmembrane transporter activity
K8M08_22435	COG1408	metallophosphoesterase
K8M08_22445	COG1113	amino acid transport
K8M08_22455	COG2322	membrane
K8M08_22460	COG1979	alcohol dehydrogenase
K8M08_22465	COG1349	DNA-binding transcription factor activity
K8M08_22470	COG1105	Belongs to the carbohydrate kinase PfkB family
K8M08_22475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8M08_22475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8M08_22475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8M08_22480	COG3584	3D domain protein
K8M08_22480	COG1388	LysM domain
K8M08_22510	COG0464	growth
K8M08_22515	COG2860	membrane
K8M08_22520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K8M08_22525	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K8M08_22530	COG0789	Transcriptional regulator
K8M08_22535	COG0174	glutamine synthetase
K8M08_22545	COG2815	serine threonine protein kinase
K8M08_22545	COG0515	serine threonine protein kinase
K8M08_22560	COG1396	sequence-specific DNA binding
K8M08_22590	COG1484	DNA-dependent DNA replication
K8M08_22660	COG0582	viral genome integration into host DNA
K8M08_22780	COG4824	toxin secretion phage lysis holin
K8M08_22840	COG1695	Transcriptional regulator
K8M08_22860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K8M08_22870	COG0737	Belongs to the 5'-nucleotidase family
K8M08_22875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8M08_22885	COG3639	organic phosphonate transmembrane transporter activity
K8M08_22910	COG1132	(ABC) transporter
K8M08_22915	COG1132	(ABC) transporter
K8M08_22930	COG3409	Peptidoglycan-binding domain 1 protein
K8M08_22930	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8M08_22940	COG0730	response to heat
K8M08_22955	COG1346	cytolysis
K8M08_22965	COG0583	DNA-binding transcription factor activity
K8M08_22975	COG1131	(ABC) transporter
K8M08_22985	COG1473	amidohydrolase
K8M08_22995	COG0785	Cytochrome C biogenesis protein
K8M08_23000	COG4846	Membrane protein involved in cytochrome C biogenesis
K8M08_23025	COG2226	methyltransferase
K8M08_23050	COG0010	Belongs to the arginase family
K8M08_23055	COG1329	Transcriptional regulator
K8M08_23060	COG1902	pentaerythritol trinitrate reductase activity
K8M08_23065	COG0069	glutamate synthase activity
K8M08_23075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8M08_23080	COG0346	lactoylglutathione lyase activity
K8M08_23085	COG0400	carboxylic ester hydrolase activity
K8M08_23090	COG5002	protein histidine kinase activity
K8M08_23100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_23150	COG1396	sequence-specific DNA binding
K8M08_23165	COG0318	PFAM AMP-dependent synthetase and ligase
K8M08_23170	COG1268	BioY protein
K8M08_23175	COG0318	PFAM AMP-dependent synthetase and ligase
K8M08_23180	COG0183	Belongs to the thiolase family
K8M08_23195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8M08_23205	COG2211	Major facilitator Superfamily
K8M08_23235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K8M08_23240	COG2274	protein secretion by the type I secretion system
K8M08_23250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8M08_23280	COG0824	Thioesterase
K8M08_23285	COG4841	protein insertion into membrane
K8M08_23305	COG0745	RESPONSE REGULATOR receiver
K8M08_23310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8M08_23315	COG1832	CoA-binding protein
K8M08_23320	COG0187	DNA topoisomerase II activity
K8M08_23325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K8M08_23330	COG0673	inositol 2-dehydrogenase activity
K8M08_23350	COG1131	(ABC) transporter
K8M08_23365	COG1595	DNA-templated transcription, initiation
K8M08_23375	COG1316	TRANSCRIPTIONal
K8M08_23385	COG4166	transmembrane transport
K8M08_23390	COG4166	transmembrane transport
K8M08_23395	COG4166	transmembrane transport
K8M08_23400	COG2226	methyltransferase
K8M08_23435	COG0531	amino acid
K8M08_23450	COG0697	spore germination
K8M08_23455	COG3383	formate dehydrogenase (NAD+) activity
K8M08_23460	COG2427	Protein of unknown function (DUF1641)
K8M08_23465	COG5609	conserved protein (DUF2294)
K8M08_23470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K8M08_23480	COG2116	formate transmembrane transporter activity
K8M08_23485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8M08_23490	COG0303	'Molybdopterin
K8M08_23495	COG0314	molybdopterin synthase activity
K8M08_23505	COG0489	protein tyrosine kinase activity
K8M08_23520	COG3326	Membrane
K8M08_23525	COG2962	Rard protein
K8M08_23530	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K8M08_23535	COG1657	PFAM Prenyltransferase squalene oxidase
K8M08_23545	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_23550	COG1012	belongs to the aldehyde dehydrogenase family
K8M08_23560	COG4145	pantothenate transmembrane transporter activity
K8M08_23575	COG0165	Argininosuccinate lyase
K8M08_23585	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_23605	COG0494	nUDIX hydrolase
K8M08_23615	COG0716	FMN binding
K8M08_23655	COG2720	vancomycin resistance protein
K8M08_23660	COG2514	catechol 2,3-dioxygenase activity
K8M08_23675	COG1285	pathogenesis
K8M08_23685	COG3852	Histidine kinase
K8M08_23715	COG1309	transcriptional regulator
K8M08_23730	COG0825	malonyl-CoA metabolic process
K8M08_23740	COG0277	FAD linked oxidase domain protein
K8M08_23745	COG0385	Bile acid
K8M08_23755	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K8M08_23760	COG2808	Putative FMN-binding domain
K8M08_23770	COG0457	Tetratricopeptide repeat
K8M08_23780	COG0604	alcohol dehydrogenase
K8M08_23785	COG0640	Transcriptional regulator
K8M08_23795	COG0584	glycerophosphoryl diester phosphodiesterase
K8M08_23825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8M08_23840	COG3781	membrane
K8M08_23865	COG1164	Oligoendopeptidase f
K8M08_23870	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K8M08_23885	COG1193	negative regulation of DNA recombination
K8M08_23905	COG0583	DNA-binding transcription factor activity
K8M08_23920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8M08_23940	COG3739	integral membrane protein
K8M08_23945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_23950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8M08_23955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_23970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K8M08_23975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K8M08_24005	COG2814	Major facilitator Superfamily
K8M08_24010	COG1113	amino acid transport
K8M08_24050	COG2072	flavoprotein involved in K transport
K8M08_24085	COG3757	hydrolase, family 25
K8M08_24085	COG3409	Peptidoglycan-binding domain 1 protein
K8M08_24100	COG1151	hydroxylamine reductase activity
K8M08_24130	COG3152	Membrane
K8M08_24150	COG1280	lysine exporter protein (LysE YggA)
K8M08_24160	COG1191	sigma factor activity
K8M08_24195	COG1733	regulation of RNA biosynthetic process
K8M08_24200	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8M08_24205	COG0318	PFAM AMP-dependent synthetase and ligase
K8M08_24230	COG0384	phenazine biosynthesis protein PhzF
K8M08_24250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_24270	COG1733	regulation of RNA biosynthetic process
K8M08_24275	COG1733	regulation of RNA biosynthetic process
K8M08_24280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K8M08_24285	COG0673	inositol 2-dehydrogenase activity
K8M08_24290	COG2188	Transcriptional regulator
K8M08_24295	COG1733	regulation of RNA biosynthetic process
K8M08_24300	COG1393	Belongs to the ArsC family
K8M08_24325	COG0814	amino acid
K8M08_24330	COG0346	lactoylglutathione lyase activity
K8M08_24345	COG2814	Major facilitator Superfamily
K8M08_24350	COG0656	L-ascorbic acid biosynthetic process
K8M08_24365	COG1733	regulation of RNA biosynthetic process
K8M08_24370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8M08_24370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8M08_24375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8M08_24375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8M08_24385	COG0840	transmembrane signaling receptor activity
K8M08_24400	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_24415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8M08_24420	COG0604	alcohol dehydrogenase
K8M08_24425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K8M08_24430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K8M08_24440	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K8M08_24445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K8M08_24455	COG1070	Carbohydrate kinase
K8M08_24460	COG2706	6-phosphogluconolactonase activity
K8M08_24465	COG3813	Protein conserved in bacteria
K8M08_24470	COG1357	PFAM Pentapeptide repeats (8 copies)
K8M08_24475	COG0697	spore germination
K8M08_24500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K8M08_24510	COG0789	Transcriptional regulator
K8M08_24515	COG1253	flavin adenine dinucleotide binding
K8M08_24545	COG0477	Major facilitator Superfamily
K8M08_24555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K8M08_24585	COG0628	permease
K8M08_24605	COG0577	efflux transmembrane transporter activity
K8M08_24605	COG1136	(ABC) transporter
K8M08_24615	COG0110	maltose O-acetyltransferase activity
K8M08_24625	COG1940	carbohydrate kinase activity
K8M08_24630	COG0346	lactoylglutathione lyase activity
K8M08_24650	COG2365	Tyrosine phosphatase family
K8M08_24660	COG1011	Hydrolase
K8M08_24685	COG1131	(ABC) transporter
K8M08_24695	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_24715	COG0778	Nitroreductase
K8M08_24720	COG1733	regulation of RNA biosynthetic process
K8M08_24740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K8M08_24755	COG3620	sequence-specific DNA binding
K8M08_24770	COG2356	endonuclease I
K8M08_24775	COG1288	antiporter activity
K8M08_24780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K8M08_24795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K8M08_24835	COG2031	fatty acid transporter
K8M08_24850	COG1309	transcriptional regulator
K8M08_24855	COG2076	Multidrug Resistance protein
K8M08_24875	COG1131	(ABC) transporter
K8M08_24880	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K8M08_24890	COG2814	Major facilitator Superfamily
K8M08_24895	COG1846	Transcriptional regulator
K8M08_24910	COG0477	Major facilitator Superfamily
K8M08_24920	COG2843	Capsule synthesis protein
K8M08_24925	COG1876	peptidase activity
K8M08_24955	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8M08_24955	COG3409	Peptidoglycan-binding domain 1 protein
K8M08_24975	COG2207	Transcriptional regulator
K8M08_24975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8M08_24980	COG0662	Cupin 2, conserved barrel domain protein
K8M08_25000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8M08_25020	COG0531	amino acid
K8M08_25025	COG1522	sequence-specific DNA binding
K8M08_25030	COG1335	isochorismatase
K8M08_25040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
K8M08_25045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K8M08_25055	COG1760	l-serine dehydratase
K8M08_25060	COG1760	l-serine dehydratase
K8M08_25065	COG0814	amino acid
K8M08_25110	COG1619	proteins homologs of microcin C7 resistance protein MccF
K8M08_25135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8M08_25145	COG3850	Histidine kinase
K8M08_25145	COG5002	protein histidine kinase activity
K8M08_25165	COG0577	efflux transmembrane transporter activity
K8M08_25185	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K8M08_25205	COG1476	TRANSCRIPTIONal
K8M08_25225	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K8M08_25270	COG2814	Major facilitator Superfamily
K8M08_25295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8M08_25305	COG2169	Transcriptional regulator
K8M08_25325	COG0346	lactoylglutathione lyase activity
K8M08_25340	COG1522	sequence-specific DNA binding
K8M08_25345	COG1028	Short-chain dehydrogenase reductase Sdr
K8M08_25385	COG1309	transcriptional regulator
K8M08_25390	COG2814	Major facilitator Superfamily
K8M08_25400	COG1309	transcriptional regulator
K8M08_25405	COG3320	Male sterility
K8M08_25405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8M08_25440	COG0519	Catalyzes the synthesis of GMP from XMP
K8M08_25450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K8M08_25460	COG0640	Transcriptional regulator
K8M08_25465	COG0346	lactoylglutathione lyase activity
K8M08_25470	COG0798	PFAM Bile acid sodium symporter
K8M08_25500	COG0577	efflux transmembrane transporter activity
K8M08_25505	COG1136	(ABC) transporter
K8M08_25510	COG4641	Protein conserved in bacteria
K8M08_25515	COG1575	Belongs to the MenA family. Type 1 subfamily
K8M08_25525	COG0697	spore germination
K8M08_25540	COG5609	conserved protein (DUF2294)
K8M08_25545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K8M08_25555	COG0288	reversible hydration of carbon dioxide
K8M08_25570	COG0415	Belongs to the DNA photolyase family
K8M08_25595	COG0697	spore germination
K8M08_25600	COG0814	amino acid
K8M08_25640	COG0598	Magnesium transport protein CorA
K8M08_25650	COG0583	DNA-binding transcription factor activity
K8M08_25670	COG1335	isochorismatase
K8M08_25675	COG2267	carboxylic ester hydrolase activity
K8M08_25680	COG0753	catalase activity
K8M08_25685	COG0737	Belongs to the 5'-nucleotidase family
K8M08_25715	COG1115	amino acid carrier protein
K8M08_25720	COG2066	Belongs to the glutaminase family
K8M08_25725	COG4191	Histidine kinase
K8M08_25730	COG0784	Response regulator, receiver
K8M08_25735	COG0697	spore germination
K8M08_25740	COG0531	amino acid
K8M08_25750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8M08_25755	COG0531	amino acid
K8M08_25760	COG0322	excinuclease ABC activity
K8M08_25775	COG2207	Transcriptional regulator
K8M08_25805	COG5002	protein histidine kinase activity
K8M08_25815	COG1396	sequence-specific DNA binding
K8M08_25820	COG0252	asparaginase activity
K8M08_25825	COG1027	Aspartate ammonia-lyase
K8M08_25830	COG1063	alcohol dehydrogenase
K8M08_25850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8M08_25860	COG0574	Belongs to the PEP-utilizing enzyme family
K8M08_25860	COG3848	Pyruvate phosphate dikinase
K8M08_25875	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K8M08_25890	COG3314	Sporulation integral membrane protein YlbJ
K8M08_25905	COG1960	acyl-CoA dehydrogenase activity
K8M08_25910	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8M08_25915	COG3142	Participates in the control of copper homeostasis
K8M08_25925	COG1414	Transcriptional regulator
K8M08_25930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K8M08_25935	COG1984	allophanate hydrolase subunit 2
K8M08_25970	COG0768	penicillin binding
K8M08_26005	COG4335	DNA alkylation repair
K8M08_26015	COG0833	amino acid
K8M08_26025	COG0730	response to heat
K8M08_26065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8M08_26085	COG0456	acetyltransferase
K8M08_26090	COG2207	Transcriptional regulator
K8M08_26115	COG1136	(ABC) transporter
K8M08_26125	COG4884	unkown
K8M08_26125	COG3831	ATPase activity
K8M08_26145	COG1846	Transcriptional regulator
K8M08_26150	COG0778	Nitroreductase
K8M08_26170	COG0659	secondary active sulfate transmembrane transporter activity
K8M08_26175	COG2824	Alkylphosphonate utilization operon protein PhnA
K8M08_26180	COG0714	Associated with various cellular activities
K8M08_26205	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K8M08_26220	COG0753	catalase activity
K8M08_26225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8M08_26245	COG0714	Associated with various cellular activities
K8M08_26270	COG0346	lactoylglutathione lyase activity
K8M08_26285	COG3279	Response regulator of the LytR AlgR family
K8M08_26295	COG4377	Putative membrane peptidase family (DUF2324)
K8M08_26310	COG3655	Transcriptional regulator
K8M08_26320	COG1785	Belongs to the alkaline phosphatase family
K8M08_26330	COG3239	Fatty acid desaturase
K8M08_26345	COG0833	amino acid
K8M08_26350	COG1414	Transcriptional regulator
K8M08_26355	COG4187	Peptidase family M20/M25/M40
K8M08_26360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8M08_26375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8M08_26395	COG2329	Antibiotic biosynthesis monooxygenase
K8M08_26430	COG1070	Carbohydrate kinase
K8M08_26435	COG2390	Transcriptional regulator
K8M08_26450	COG1172	Belongs to the binding-protein-dependent transport system permease family
K8M08_26470	COG1388	LysM domain
K8M08_26470	COG3584	3D domain protein
K8M08_26500	COG1605	Chorismate mutase
K8M08_26500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K8M08_26510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K8M08_26515	COG0287	Prephenate dehydrogenase
K8M08_26530	COG1309	transcriptional regulator
K8M08_26535	COG2409	Drug exporters of the RND superfamily
K8M08_26535	COG1033	growth of symbiont in host cell
K8M08_26545	COG0488	(ABC) transporter
K8M08_26550	COG1368	sulfuric ester hydrolase activity
K8M08_26555	COG0861	Integral membrane protein TerC family
K8M08_26560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8M08_26585	COG0346	lactoylglutathione lyase activity
K8M08_26615	COG2318	DinB family
K8M08_26620	COG0697	spore germination
K8M08_26640	COG2746	aminoglycoside 3-N-acetyltransferase activity
K8M08_26685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K8M08_26690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K8M08_26695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8M08_26710	COG0628	permease
K8M08_26750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K8M08_26760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8M08_26765	COG0436	Aminotransferase
K8M08_26805	COG2226	methyltransferase
K8M08_26820	COG2261	transglycosylase associated protein
K8M08_26845	COG2814	Major facilitator Superfamily
K8M08_26845	COG0477	Major facilitator Superfamily
K8M08_26850	COG4533	DNA binding
K8M08_26855	COG0789	Transcriptional regulator
K8M08_26860	COG1664	Polymer-forming cytoskeletal
K8M08_26870	COG2814	Major facilitator Superfamily
K8M08_26920	COG1307	EDD domain protein, DegV family
K8M08_26930	COG1164	Oligoendopeptidase f
K8M08_26965	COG0745	RESPONSE REGULATOR receiver
K8M08_26970	COG5002	protein histidine kinase activity
K8M08_26970	COG3850	Histidine kinase
K8M08_26975	COG2936	dipeptidyl-peptidase activity
K8M08_27025	COG4948	Mandelate Racemase Muconate Lactonizing
K8M08_27035	COG4166	transmembrane transport
K8M08_27055	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K8M08_27070	COG0586	Pfam SNARE associated Golgi protein
K8M08_27110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8M08_27115	COG3938	Belongs to the proline racemase family
K8M08_27125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)