locus-tag	class	description
DS740_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DS740_00010	COG0592	DNA-directed DNA polymerase activity
DS740_00015	COG2501	S4 domain
DS740_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DS740_00030	COG0187	DNA topoisomerase II activity
DS740_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DS740_00070	COG0517	IMP dehydrogenase activity
DS740_00070	COG0516	GMP reductase activity
DS740_00075	COG1686	Belongs to the peptidase S11 family
DS740_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DS740_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DS740_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DS740_00100	COG1428	Deoxynucleoside kinase
DS740_00105	COG1428	Deoxynucleoside kinase
DS740_00110	COG3858	chitin binding
DS740_00110	COG1388	LysM domain
DS740_00115	COG1335	isochorismatase
DS740_00120	COG0590	tRNA wobble adenosine to inosine editing
DS740_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DS740_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DS740_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DS740_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DS740_00190	COG3853	Toxic anion resistance protein (TelA)
DS740_00195	COG1982	Orn Lys Arg decarboxylase major
DS740_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DS740_00205	COG3870	Protein conserved in bacteria
DS740_00210	COG1728	Protein conserved in bacteria
DS740_00215	COG0470	DNA polymerase III
DS740_00220	COG1774	PSP1 C-terminal conserved region
DS740_00225	COG4467	Involved in initiation control of chromosome replication
DS740_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DS740_00235	COG2827	Endonuclease containing a URI domain
DS740_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DS740_00245	COG2002	toxin-antitoxin pair type II binding
DS740_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS740_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS740_00255	COG0084	hydrolase, TatD family'
DS740_00260	COG3584	3D domain protein
DS740_00260	COG3583	domain protein
DS740_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DS740_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DS740_00280	COG4466	Protein conserved in bacteria
DS740_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DS740_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DS740_00305	COG2088	sporulation resulting in formation of a cellular spore
DS740_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DS740_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DS740_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DS740_00325	COG0193	aminoacyl-tRNA hydrolase activity
DS740_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DS740_00340	COG2002	toxin-antitoxin pair type II binding
DS740_00345	COG2244	polysaccharide biosynthetic process
DS740_00350	COG3956	TIGRFAM MazG family protein
DS740_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DS740_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DS740_00375	COG1098	S1 RNA binding domain
DS740_00390	COG2208	phosphoserine phosphatase activity
DS740_00395	COG2304	oxidoreductase activity
DS740_00400	COG0515	serine threonine protein kinase
DS740_00405	COG0037	tRNA processing
DS740_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DS740_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DS740_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DS740_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS740_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS740_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DS740_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
DS740_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS740_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DS740_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DS740_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DS740_00470	COG1396	sequence-specific DNA binding
DS740_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS740_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DS740_00560	COG4463	regulation of RNA biosynthetic process
DS740_00565	COG3880	PFAM UvrB UvrC protein
DS740_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DS740_00575	COG0542	response to heat
DS740_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DS740_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DS740_00590	COG4956	integral membrane protein (PIN domain superfamily)
DS740_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DS740_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DS740_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DS740_00615	COG1045	serine acetyltransferase
DS740_00620	COG0215	cysteine-tRNA ligase activity
DS740_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DS740_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DS740_00635	COG3688	RNA-binding protein containing a PIN domain
DS740_00640	COG1595	DNA-templated transcription, initiation
DS740_00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DS740_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DS740_00655	COG0250	Participates in transcription elongation, termination and antitermination
DS740_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DS740_00665	COG0081	regulation of translation
DS740_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DS740_00675	COG0222	ribosome binding
DS740_00680	COG2813	Specifically methylates the guanine in position
DS740_00685	COG0085	RNA polymerase activity
DS740_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DS740_00695	COG1358	cellular component organization or biogenesis
DS740_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DS740_00705	COG0049	tRNA binding
DS740_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DS740_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DS740_00720	COG0596	Alpha beta hydrolase
DS740_00725	COG0051	transcription antitermination factor activity, RNA binding
DS740_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DS740_00735	COG0088	Forms part of the polypeptide exit tunnel
DS740_00740	COG0089	rRNA binding
DS740_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DS740_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DS740_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DS740_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DS740_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DS740_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
DS740_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DS740_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DS740_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DS740_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DS740_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DS740_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DS740_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DS740_00820	COG1841	ribosomal large subunit assembly
DS740_00825	COG0200	Binds to the 23S rRNA
DS740_00830	COG0201	protein transport
DS740_00835	COG0563	adenylate kinase activity
DS740_00840	COG0024	Methionine aminopeptidase
DS740_00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
DS740_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DS740_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DS740_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DS740_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DS740_00870	COG0202	RNA polymerase activity
DS740_00875	COG0203	ribosomal protein L17
DS740_00880	COG1122	ATPase activity
DS740_00885	COG1122	ATPase activity
DS740_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DS740_00895	COG0101	tRNA pseudouridine synthase activity
DS740_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DS740_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DS740_00910	COG2226	methyltransferase
DS740_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
DS740_00925	COG0489	protein tyrosine kinase activity
DS740_00935	COG2194	sulfuric ester hydrolase activity
DS740_00940	COG0726	polysaccharide deacetylase
DS740_01020	COG0659	secondary active sulfate transmembrane transporter activity
DS740_01025	COG0385	Bile acid
DS740_01030	COG2819	hydrolase of the alpha beta superfamily
DS740_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS740_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS740_01050	COG2207	Transcriptional regulator
DS740_01055	COG3876	Protein conserved in bacteria
DS740_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
DS740_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS740_01070	COG1263	PTS System
DS740_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_01075	COG1737	Transcriptional regulator
DS740_01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DS740_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_01090	COG1683	Conserved Protein
DS740_01120	COG1595	DNA-templated transcription, initiation
DS740_01125	COG5662	AntiSigma factor
DS740_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DS740_01135	COG4856	YbbR-like protein
DS740_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DS740_01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DS740_01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DS740_01160	COG2169	Transcriptional regulator
DS740_01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DS740_01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DS740_01175	COG3002	Belongs to the UPF0753 family
DS740_01180	COG0288	reversible hydration of carbon dioxide
DS740_01190	COG5609	conserved protein (DUF2294)
DS740_01195	COG0640	Transcriptional regulator
DS740_01200	COG2814	Major facilitator Superfamily
DS740_01215	COG0515	serine threonine protein kinase
DS740_01230	COG1113	amino acid transport
DS740_01245	COG2602	Beta-lactamase
DS740_01250	COG2124	cytochrome p450
DS740_01260	COG0531	amino acid
DS740_01265	COG0584	glycerophosphoryl diester phosphodiesterase
DS740_01270	COG2271	Major facilitator Superfamily
DS740_01285	COG0456	acetyltransferase
DS740_01285	COG1846	Transcriptional regulator
DS740_01290	COG2271	Major facilitator Superfamily
DS740_01300	COG3409	Peptidoglycan-binding domain 1 protein
DS740_01305	COG0697	spore germination
DS740_01310	COG1917	Cupin 2, conserved barrel domain protein
DS740_01310	COG2207	Transcriptional regulator
DS740_01315	COG1397	ADP-ribosylglycohydrolase
DS740_01320	COG5444	nuclease activity
DS740_01325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DS740_01330	COG3591	Belongs to the peptidase S1B family
DS740_01340	COG0596	Alpha beta hydrolase
DS740_01345	COG1183	phosphatidylcholine synthase activity
DS740_01350	COG0586	Pfam SNARE associated Golgi protein
DS740_01355	COG0688	phosphatidylethanolamine metabolic process
DS740_01365	COG2312	Erythromycin esterase
DS740_01375	COG1301	dicarboxylic acid transport
DS740_01380	COG2190	(PTS) system
DS740_01380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_01380	COG1263	PTS System
DS740_01385	COG0363	glucosamine-6-phosphate deaminase activity
DS740_01400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS740_01405	COG0833	amino acid
DS740_01410	COG2040	homocysteine
DS740_01420	COG1115	amino acid carrier protein
DS740_01425	COG2066	Belongs to the glutaminase family
DS740_01430	COG4191	Histidine kinase
DS740_01435	COG0784	Response regulator, receiver
DS740_01445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DS740_01450	COG1012	belongs to the aldehyde dehydrogenase family
DS740_01455	COG2271	Major facilitator Superfamily
DS740_01460	COG4948	Mandelate Racemase Muconate Lactonizing
DS740_01465	COG2186	Transcriptional regulator
DS740_01470	COG2721	sulfolactate sulfo-lyase activity
DS740_01475	COG3173	Aminoglycoside phosphotransferase
DS740_01485	COG0697	spore germination
DS740_01490	COG0745	RESPONSE REGULATOR receiver
DS740_01495	COG2205	protein histidine kinase activity
DS740_01500	COG1131	(ABC) transporter
DS740_01515	COG3773	Cell wall hydrolase
DS740_01520	COG2304	oxidoreductase activity
DS740_01530	COG3540	Alkaline phosphatase
DS740_01535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS740_01540	COG0805	protein transport
DS740_01545	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DS740_01550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DS740_01555	COG0477	Major facilitator Superfamily
DS740_01560	COG1309	transcriptional regulator
DS740_01565	COG0252	asparaginase activity
DS740_01570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DS740_01575	COG1714	RDD family
DS740_01580	COG3012	SEC-C Motif Domain Protein
DS740_01580	COG1405	negative regulation of cell septum assembly
DS740_01585	COG3290	protein histidine kinase activity
DS740_01590	COG3279	Response regulator of the LytR AlgR family
DS740_01595	COG4555	ABC transporter
DS740_01600	COG1668	transmembrane transport
DS740_01605	COG0667	Aldo Keto reductase
DS740_01615	COG1595	DNA-templated transcription, initiation
DS740_01625	COG1595	DNA-templated transcription, initiation
DS740_01630	COG1876	peptidase activity
DS740_01635	COG0457	Tetratricopeptide repeat
DS740_01640	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_01645	COG0366	Alpha amylase catalytic
DS740_01650	COG0803	Belongs to the bacterial solute-binding protein 9 family
DS740_01655	COG1121	(ABC) transporter
DS740_01660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DS740_01665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS740_01670	COG2310	stress, protein
DS740_01675	COG2310	stress, protein
DS740_01680	COG2310	stress, protein
DS740_01685	COG0861	Integral membrane protein TerC family
DS740_01695	COG3853	Toxic anion resistance protein (TelA)
DS740_01700	COG0477	Major facilitator Superfamily
DS740_01710	COG2814	Major facilitator Superfamily
DS740_01715	COG0640	Transcriptional regulator
DS740_01720	COG4175	Glycine betaine
DS740_01720	COG0517	IMP dehydrogenase activity
DS740_01725	COG4176	ABC-type proline glycine betaine transport system permease component
DS740_01730	COG2113	Glycine betaine
DS740_01735	COG1473	amidohydrolase
DS740_01740	COG1288	antiporter activity
DS740_01750	COG0366	Alpha amylase catalytic
DS740_01755	COG0039	L-malate dehydrogenase activity
DS740_01760	COG1620	l-lactate permease
DS740_01765	COG2814	Major facilitator Superfamily
DS740_01770	COG1846	Transcriptional regulator
DS740_01775	COG1280	lysine exporter protein (LysE YggA)
DS740_01780	COG3403	YqcI/YcgG family
DS740_01785	COG1113	amino acid transport
DS740_01790	COG3665	Urea carboxylase-associated protein
DS740_01795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DS740_01800	COG1660	Displays ATPase and GTPase activities
DS740_01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DS740_01810	COG2226	methyltransferase
DS740_01815	COG0583	DNA-binding transcription factor activity
DS740_01820	COG3458	cephalosporin-C deacetylase activity
DS740_01825	COG3541	Predicted nucleotidyltransferase
DS740_01830	COG0506	proline dehydrogenase activity
DS740_01835	COG1012	belongs to the aldehyde dehydrogenase family
DS740_01840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS740_01845	COG2508	Transcriptional regulator
DS740_01850	COG3689	TIGRFAM TIGR03943 family protein
DS740_01855	COG0701	Predicted permease
DS740_01860	COG2267	carboxylic ester hydrolase activity
DS740_01865	COG0492	ferredoxin-NADP+ reductase activity
DS740_01870	COG1587	Uroporphyrinogen-III synthase
DS740_01870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DS740_01875	COG2146	nitrite reductase [NAD(P)H] activity
DS740_01880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS740_01885	COG0243	molybdopterin cofactor binding
DS740_01890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS740_01895	COG2223	nitrite transmembrane transporter activity
DS740_01900	COG1469	GTP cyclohydrolase I activity
DS740_01905	COG1376	ErfK ybiS ycfS ynhG family protein
DS740_01915	COG0523	cobalamin synthesis protein
DS740_01920	COG0765	amino acid transport
DS740_01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS740_01935	COG1714	RDD family
DS740_01945	COG2723	6-phospho-beta-galactosidase activity
DS740_01955	COG3209	COG3209 Rhs family protein
DS740_01960	COG0840	transmembrane signaling receptor activity
DS740_01960	COG3290	protein histidine kinase activity
DS740_01965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DS740_01970	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DS740_01975	COG1733	regulation of RNA biosynthetic process
DS740_01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_01995	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DS740_02000	COG2814	Major facilitator Superfamily
DS740_02010	COG0697	spore germination
DS740_02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS740_02025	COG2364	Membrane
DS740_02030	COG1126	abc transporter atp-binding protein
DS740_02035	COG0765	amino acid transport
DS740_02040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS740_02045	COG0583	DNA-binding transcription factor activity
DS740_02050	COG0163	prenyltransferase activity
DS740_02055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DS740_02070	COG0596	Alpha beta hydrolase
DS740_02075	COG3104	oligopeptide transport
DS740_02080	COG5434	Belongs to the glycosyl hydrolase 28 family
DS740_02090	COG0697	spore germination
DS740_02100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DS740_02105	COG1136	(ABC) transporter
DS740_02110	COG0577	efflux transmembrane transporter activity
DS740_02115	COG0745	RESPONSE REGULATOR receiver
DS740_02120	COG5002	protein histidine kinase activity
DS740_02120	COG3850	Histidine kinase
DS740_02125	COG0457	Tetratricopeptide repeat
DS740_02145	COG0527	aspartate kinase activity
DS740_02150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_02155	COG4605	iron ion homeostasis
DS740_02160	COG4604	ABC transporter, ATP-binding protein
DS740_02165	COG4607	ABC-type enterochelin transport system periplasmic component
DS740_02170	COG2814	Major facilitator Superfamily
DS740_02175	COG1309	transcriptional regulator
DS740_02180	COG0778	Nitroreductase
DS740_02185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DS740_02190	COG0640	Transcriptional regulator
DS740_02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS740_02200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DS740_02205	COG1012	belongs to the aldehyde dehydrogenase family
DS740_02210	COG4975	Glucose uptake
DS740_02215	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_02220	COG4549	nuclear export factor GLE1
DS740_02225	COG2372	response to copper ion
DS740_02225	COG1276	copper resistance
DS740_02230	COG1349	DNA-binding transcription factor activity
DS740_02240	COG2213	PTS system mannitol-specific
DS740_02245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_02250	COG0246	Mannitol dehydrogenase
DS740_02255	COG0473	3-isopropylmalate dehydrogenase activity
DS740_02260	COG0681	Belongs to the peptidase S26 family
DS740_02265	COG0412	Dienelactone hydrolase
DS740_02270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DS740_02280	COG0561	phosphatase activity
DS740_02285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DS740_02290	COG1914	H( )-stimulated, divalent metal cation uptake system
DS740_02295	COG4336	lyase activity
DS740_02300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DS740_02305	COG1984	allophanate hydrolase subunit 2
DS740_02310	COG1414	Transcriptional regulator
DS740_02315	COG2755	lipolytic protein G-D-S-L family
DS740_02325	COG2329	Antibiotic biosynthesis monooxygenase
DS740_02330	COG0768	penicillin binding
DS740_02335	COG4989	oxidoreductase activity
DS740_02340	COG3711	transcriptional antiterminator
DS740_02345	COG0318	PFAM AMP-dependent synthetase and ligase
DS740_02350	COG2226	methyltransferase
DS740_02355	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_02360	COG1917	Cupin 2, conserved barrel domain protein
DS740_02365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_02370	COG3871	stress protein (general stress protein 26)
DS740_02380	COG2814	Major facilitator Superfamily
DS740_02385	COG1522	sequence-specific DNA binding
DS740_02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DS740_02390	COG0551	DNA topoisomerase type I activity
DS740_02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DS740_02400	COG3706	GGDEF domain
DS740_02405	COG5298	Protein conserved in bacteria
DS740_02410	COG1215	transferase activity, transferring glycosyl groups
DS740_02420	COG0531	amino acid
DS740_02425	COG0494	nUDIX hydrolase
DS740_02430	COG0028	Belongs to the TPP enzyme family
DS740_02440	COG1914	H( )-stimulated, divalent metal cation uptake system
DS740_02445	COG2261	transglycosylase associated protein
DS740_02450	COG4876	unkown
DS740_02455	COG2217	Heavy metal translocating P-type atpase
DS740_02460	COG3729	General stress protein
DS740_02465	COG0662	Cupin 2, conserved barrel domain protein
DS740_02470	COG2329	Antibiotic biosynthesis monooxygenase
DS740_02475	COG3546	catalase activity
DS740_02480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DS740_02485	COG3290	protein histidine kinase activity
DS740_02490	COG4565	transcriptional regulatory protein
DS740_02495	COG1301	dicarboxylic acid transport
DS740_02500	COG0628	permease
DS740_02505	COG1131	(ABC) transporter
DS740_02510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DS740_02520	COG1960	acyl-CoA dehydrogenase activity
DS740_02535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DS740_02540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_02545	COG1181	Belongs to the D-alanine--D-alanine ligase family
DS740_02550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DS740_02560	COG0513	Belongs to the DEAD box helicase family
DS740_02565	COG3402	PFAM membrane-flanked domain
DS740_02570	COG3428	Bacterial PH domain
DS740_02575	COG0705	Rhomboid family
DS740_02580	COG0736	holo-[acyl-carrier-protein] synthase activity
DS740_02585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DS740_02590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DS740_02595	COG0864	Transcriptional regulator
DS740_02600	COG2337	Toxic component of a toxin-antitoxin (TA) module
DS740_02605	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_02610	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_02615	COG2172	sigma factor antagonist activity
DS740_02620	COG2208	phosphoserine phosphatase activity
DS740_02625	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_02630	COG2172	sigma factor antagonist activity
DS740_02635	COG1191	sigma factor activity
DS740_02640	COG2208	phosphoserine phosphatase activity
DS740_02645	COG2183	response to ionizing radiation
DS740_02655	COG3091	SprT-like family
DS740_02740	COG5444	nuclease activity
DS740_02750	COG1476	TRANSCRIPTIONal
DS740_02760	COG3239	Fatty acid desaturase
DS740_02765	COG1278	Cold shock
DS740_02770	COG1329	Transcriptional regulator
DS740_02780	COG0697	spore germination
DS740_02785	COG1917	Cupin 2, conserved barrel domain protein
DS740_02785	COG2207	Transcriptional regulator
DS740_02790	COG0697	spore germination
DS740_02795	COG2207	Transcriptional regulator
DS740_02795	COG3708	Transcriptional regulator
DS740_02800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS740_02805	COG0477	Major facilitator Superfamily
DS740_02815	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DS740_02835	COG1309	transcriptional regulator
DS740_02840	COG0697	spore germination
DS740_02845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS740_02850	COG2030	dehydratase
DS740_02855	COG3545	Serine hydrolase
DS740_02860	COG1733	regulation of RNA biosynthetic process
DS740_02865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DS740_02870	COG1733	regulation of RNA biosynthetic process
DS740_02875	COG2249	NAD(P)H dehydrogenase (quinone) activity
DS740_02880	COG2814	Major facilitator Superfamily
DS740_02885	COG1309	transcriptional regulator
DS740_02890	COG0640	Transcriptional regulator
DS740_02895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DS740_02905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_02910	COG0697	spore germination
DS740_02915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS740_02925	COG0640	Transcriptional regulator
DS740_02930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DS740_02945	COG4585	Histidine kinase
DS740_02950	COG2197	response regulator
DS740_02955	COG2409	Drug exporters of the RND superfamily
DS740_02960	COG0596	Alpha beta hydrolase
DS740_02965	COG1811	Na channel or pump
DS740_02970	COG0789	Transcriptional regulator
DS740_02970	COG4978	Transcriptional regulator
DS740_02975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DS740_02980	COG0778	Nitroreductase
DS740_02985	COG0346	lactoylglutathione lyase activity
DS740_02990	COG2259	Doxx family
DS740_02995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_03015	COG2323	membrane
DS740_03020	COG2323	membrane
DS740_03025	COG0071	Belongs to the small heat shock protein (HSP20) family
DS740_03040	COG1309	transcriptional regulator
DS740_03050	COG0456	acetyltransferase
DS740_03060	COG1113	amino acid transport
DS740_03065	COG2318	DinB family
DS740_03070	COG1846	Transcriptional regulator
DS740_03075	COG1033	growth of symbiont in host cell
DS740_03075	COG2409	Drug exporters of the RND superfamily
DS740_03080	COG0778	Nitroreductase
DS740_03085	COG1846	Transcriptional regulator
DS740_03090	COG2814	Major facilitator Superfamily
DS740_03095	COG0730	response to heat
DS740_03100	COG1802	Transcriptional regulator
DS740_03105	COG3858	chitin binding
DS740_03105	COG1388	LysM domain
DS740_03110	COG1819	glycosyl
DS740_03120	COG1785	Belongs to the alkaline phosphatase family
DS740_03125	COG5646	InterPro IPR014922
DS740_03135	COG0454	-acetyltransferase
DS740_03140	COG1078	dGTPase activity
DS740_03145	COG1388	LysM domain
DS740_03150	COG2814	Major facilitator Superfamily
DS740_03155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DS740_03160	COG1447	Phosphotransferase system cellobiose-specific component IIA
DS740_03165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DS740_03170	COG2723	6-phospho-beta-galactosidase activity
DS740_03175	COG2188	Transcriptional regulator
DS740_03180	COG1940	carbohydrate kinase activity
DS740_03185	COG1482	cell wall glycoprotein biosynthetic process
DS740_03190	COG4124	Belongs to the glycosyl hydrolase 26 family
DS740_03235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DS740_03240	COG0802	atpase or kinase
DS740_03245	COG1214	PFAM Peptidase M22, glycoprotease
DS740_03250	COG0456	acetyltransferase
DS740_03255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DS740_03260	COG0488	(ABC) transporter
DS740_03265	COG0315	cyclic pyranopterin monophosphate synthase activity
DS740_03270	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DS740_03275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS740_03280	COG0805	protein transport
DS740_03295	COG1266	CAAX protease self-immunity
DS740_03300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DS740_03305	COG0459	protein refolding
DS740_03315	COG1073	alpha beta
DS740_03320	COG0457	Tetratricopeptide repeat
DS740_03325	COG1063	alcohol dehydrogenase
DS740_03330	COG2211	Major facilitator Superfamily
DS740_03335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS740_03340	COG1842	Phage shock protein A
DS740_03345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DS740_03350	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DS740_03355	COG4260	virion core protein, lumpy skin disease virus
DS740_03365	COG2814	Major facilitator Superfamily
DS740_03370	COG1063	alcohol dehydrogenase
DS740_03375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DS740_03380	COG0823	Involved in the tonB-independent uptake of proteins
DS740_03395	COG2267	carboxylic ester hydrolase activity
DS740_03405	COG2132	Multicopper oxidase
DS740_03410	COG1113	amino acid transport
DS740_03420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DS740_03425	COG0714	Associated with various cellular activities
DS740_03430	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DS740_03435	COG1305	Transglutaminase-like
DS740_03440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DS740_03440	COG0519	Catalyzes the synthesis of GMP from XMP
DS740_03455	COG2252	PERMEase
DS740_03460	COG3064	Membrane
DS740_03470	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DS740_03480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DS740_03485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DS740_03490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DS740_03495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DS740_03500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DS740_03505	COG0047	phosphoribosylformylglycinamidine synthase activity
DS740_03510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DS740_03515	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DS740_03520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DS740_03525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DS740_03530	COG0138	bifunctional purine biosynthesis protein purh
DS740_03535	COG0151	Belongs to the GarS family
DS740_03540	COG1522	sequence-specific DNA binding
DS740_03545	COG0531	amino acid
DS740_03555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DS740_03560	COG1470	cell adhesion involved in biofilm formation
DS740_03565	COG4496	protein, YerC YecD
DS740_03570	COG0069	glutamate synthase activity
DS740_03575	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DS740_03580	COG0210	DNA helicase
DS740_03585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DS740_03590	COG4851	CamS sex pheromone cAM373 precursor
DS740_03595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS740_03600	COG1285	pathogenesis
DS740_03605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS740_03610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DS740_03615	COG0154	amidase activity
DS740_03620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DS740_03625	COG1309	transcriptional regulator
DS740_03630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DS740_03635	COG1597	lipid kinase activity
DS740_03640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DS740_03655	COG5444	nuclease activity
DS740_03660	COG3391	amine dehydrogenase activity
DS740_03665	COG0457	Tetratricopeptide repeat
DS740_03675	COG0217	transcriptional regulatory protein
DS740_03685	COG1309	transcriptional regulator
DS740_03690	COG3631	Ketosteroid isomerase-related protein
DS740_03695	COG0702	epimerase
DS740_03710	COG3546	catalase activity
DS740_03715	COG0454	-acetyltransferase
DS740_03725	COG5578	integral membrane protein
DS740_03730	COG2972	Histidine kinase
DS740_03735	COG2207	Transcriptional regulator
DS740_03735	COG4753	response regulator
DS740_03740	COG1653	transport
DS740_03745	COG1175	transmembrane transport
DS740_03750	COG0395	ABC-type sugar transport system, permease component
DS740_03755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DS740_03760	COG2207	Transcriptional regulator
DS740_03765	COG2755	lipolytic protein G-D-S-L family
DS740_03775	COG5578	integral membrane protein
DS740_03780	COG3401	FG-GAP repeat protein
DS740_03785	COG3401	FG-GAP repeat protein
DS740_03790	COG2755	lipolytic protein G-D-S-L family
DS740_03795	COG1874	Beta-galactosidase
DS740_03805	COG1653	transport
DS740_03810	COG4209	transmembrane transport
DS740_03815	COG0395	ABC-type sugar transport system, permease component
DS740_03820	COG1486	melibiose metabolic process
DS740_03825	COG2323	membrane
DS740_03830	COG2329	Antibiotic biosynthesis monooxygenase
DS740_03835	COG0346	lactoylglutathione lyase activity
DS740_03850	COG5583	Uncharacterized small protein (DUF2292)
DS740_03855	COG0670	Belongs to the BI1 family
DS740_03860	COG0697	spore germination
DS740_03865	COG1846	Transcriptional regulator
DS740_03870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS740_03885	COG2124	cytochrome p450
DS740_03885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS740_03890	COG1368	sulfuric ester hydrolase activity
DS740_03895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DS740_03900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS740_03905	COG1442	glycosyl transferase family 8
DS740_03910	COG1216	Glycosyl transferase, family 2
DS740_03915	COG1442	glycosyl transferase family 8
DS740_03920	COG2223	nitrite transmembrane transporter activity
DS740_03925	COG1011	Hydrolase
DS740_03930	COG0531	amino acid
DS740_03935	COG1012	belongs to the aldehyde dehydrogenase family
DS740_03940	COG0840	transmembrane signaling receptor activity
DS740_03945	COG0488	(ABC) transporter
DS740_03955	COG0789	Transcriptional regulator
DS740_03960	COG2814	Major facilitator Superfamily
DS740_03965	COG1404	Belongs to the peptidase S8 family
DS740_03980	COG0488	(ABC) transporter
DS740_03985	COG0513	Belongs to the DEAD box helicase family
DS740_03990	COG0456	acetyltransferase
DS740_03995	COG2130	NADP-dependent
DS740_04000	COG1120	ATPase activity
DS740_04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_04015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DS740_04035	COG3866	Pectate lyase
DS740_04040	COG0471	metal ion transport
DS740_04045	COG3290	protein histidine kinase activity
DS740_04050	COG4565	transcriptional regulatory protein
DS740_04055	COG3181	Tripartite tricarboxylate transporter family receptor
DS740_04060	COG2851	Citrate transporter
DS740_04065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_04070	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DS740_04075	COG1254	Belongs to the acylphosphatase family
DS740_04080	COG2258	MOSC domain
DS740_04100	COG0024	Methionine aminopeptidase
DS740_04105	COG1263	PTS System
DS740_04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_04110	COG1368	sulfuric ester hydrolase activity
DS740_04125	COG1115	amino acid carrier protein
DS740_04130	COG0531	amino acid
DS740_04145	COG0697	spore germination
DS740_04150	COG1263	PTS System
DS740_04150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_04155	COG0366	Alpha amylase catalytic
DS740_04160	COG2188	Transcriptional regulator
DS740_04165	COG0778	Nitroreductase
DS740_04170	COG0737	Belongs to the 5'-nucleotidase family
DS740_04175	COG0693	protein deglycase activity
DS740_04180	COG2814	Major facilitator Superfamily
DS740_04185	COG4840	Belongs to the UPF0435 family
DS740_04190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DS740_04195	COG4980	gas vesicle protein
DS740_04200	COG1295	ribonuclease BN
DS740_04205	COG0477	Major facilitator Superfamily
DS740_04210	COG0387	Pfam Sodium calcium exchanger
DS740_04220	COG0668	transmembrane transport
DS740_04225	COG0535	radical SAM domain protein
DS740_04235	COG0726	polysaccharide deacetylase
DS740_04240	COG2084	Dehydrogenase
DS740_04245	COG0598	Magnesium transport protein CorA
DS740_04250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DS740_04255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DS740_04265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DS740_04270	COG4637	Psort location Cytoplasmic, score
DS740_04275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DS740_04280	COG0022	dehydrogenase e1 component
DS740_04285	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS740_04290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS740_04295	COG3284	Transcriptional regulator
DS740_04305	COG1742	UPF0060 membrane protein
DS740_04330	COG4842	Belongs to the WXG100 family
DS740_04335	COG1486	melibiose metabolic process
DS740_04340	COG1737	Transcriptional regulator
DS740_04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_04345	COG1263	PTS System
DS740_04350	COG5434	Belongs to the glycosyl hydrolase 28 family
DS740_04355	COG1132	(ABC) transporter
DS740_04360	COG1132	(ABC) transporter
DS740_04365	COG2259	Doxx family
DS740_04370	COG2514	catechol 2,3-dioxygenase activity
DS740_04375	COG4585	Histidine kinase
DS740_04380	COG2197	response regulator
DS740_04390	COG1131	(ABC) transporter
DS740_04395	COG0842	Transport permease protein
DS740_04395	COG1511	domain protein
DS740_04400	COG0842	Transport permease protein
DS740_04405	COG1695	Transcriptional regulator
DS740_04410	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DS740_04415	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DS740_04420	COG2318	DinB family
DS740_04425	COG2814	Major facilitator Superfamily
DS740_04430	COG1846	Transcriptional regulator
DS740_04435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DS740_04435	COG0392	lysyltransferase activity
DS740_04440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS740_04445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_04450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_04455	COG0384	phenazine biosynthesis protein PhzF
DS740_04460	COG0778	Nitroreductase
DS740_04475	COG1090	epimerase
DS740_04480	COG2137	regulation of response to DNA damage stimulus
DS740_04490	COG2814	Major facilitator Superfamily
DS740_04505	COG3103	Sh3 type 3 domain protein
DS740_04510	COG5658	integral membrane protein
DS740_04515	COG0596	Alpha beta hydrolase
DS740_04520	COG0463	Glycosyl transferase, family 2
DS740_04525	COG4485	Bacterial membrane protein, YfhO
DS740_04530	COG1988	membrane-bound metal-dependent
DS740_04535	COG1194	a g-specific adenine glycosylase
DS740_04545	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_04560	COG3557	Belongs to the UPF0374 family
DS740_04565	COG1132	(ABC) transporter
DS740_04570	COG4129	membrane
DS740_04575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DS740_04580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DS740_04585	COG0735	belongs to the Fur family
DS740_04695	COG4326	sporulation control protein
DS740_04705	COG5577	PFAM Coat F domain
DS740_04715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DS740_04730	COG0753	catalase activity
DS740_04735	COG1116	anion transmembrane transporter activity
DS740_04740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS740_04745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS740_04750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS740_04760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DS740_04770	COG1476	TRANSCRIPTIONal
DS740_04780	COG3382	B3 4 domain protein
DS740_04785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DS740_04795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DS740_04800	COG0789	Transcriptional regulator
DS740_04805	COG1664	Polymer-forming cytoskeletal
DS740_04810	COG1664	Polymer-forming cytoskeletal
DS740_04815	COG2766	serine protein kinase
DS740_04820	COG2718	Belongs to the UPF0229 family
DS740_04825	COG1846	Transcriptional regulator
DS740_04830	COG1566	PFAM secretion protein HlyD family protein
DS740_04835	COG2814	Major facilitator Superfamily
DS740_04840	COG0655	NAD(P)H dehydrogenase (quinone) activity
DS740_04860	COG1725	Transcriptional regulator
DS740_04865	COG1131	(ABC) transporter
DS740_04870	COG1131	(ABC) transporter
DS740_04875	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DS740_04880	COG1278	Cold shock
DS740_04890	COG1464	Belongs to the NlpA lipoprotein family
DS740_04895	COG3706	GGDEF domain
DS740_04900	COG1823	symporter activity
DS740_04930	COG5577	PFAM Coat F domain
DS740_04935	COG4085	toxin activity
DS740_04935	COG0737	Belongs to the 5'-nucleotidase family
DS740_04935	COG1525	nuclease
DS740_04940	COG3764	Sortase (surface protein transpeptidase)
DS740_04945	COG0564	pseudouridine synthase activity
DS740_04955	COG0517	IMP dehydrogenase activity
DS740_04960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DS740_04965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS740_04965	COG3153	acetyltransferase
DS740_04975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DS740_04980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DS740_04985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DS740_04990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DS740_04995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DS740_05000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DS740_05005	COG4585	Histidine kinase
DS740_05005	COG2203	Gaf domain
DS740_05010	COG2197	response regulator
DS740_05015	COG0431	NADPH-dependent FMN reductase
DS740_05030	COG1388	LysM domain
DS740_05030	COG0791	NLP P60 protein
DS740_05035	COG1959	2 iron, 2 sulfur cluster binding
DS740_05040	COG0668	transmembrane transport
DS740_05045	COG2719	SpoVR family
DS740_05050	COG1785	Belongs to the alkaline phosphatase family
DS740_05055	COG1388	LysM domain
DS740_05055	COG0791	NLP P60 protein
DS740_05060	COG0583	DNA-binding transcription factor activity
DS740_05065	COG0372	Belongs to the citrate synthase family
DS740_05070	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_05075	COG0531	amino acid
DS740_05080	COG0733	neurotransmitter:sodium symporter activity
DS740_05085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS740_05090	COG0456	acetyltransferase
DS740_05105	COG1595	DNA-templated transcription, initiation
DS740_05110	COG0667	Aldo Keto reductase
DS740_05115	COG0204	Acyl-transferase
DS740_05120	COG1253	flavin adenine dinucleotide binding
DS740_05125	COG0789	Transcriptional regulator
DS740_05130	COG0436	Aminotransferase
DS740_05135	COG1253	flavin adenine dinucleotide binding
DS740_05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DS740_05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DS740_05150	COG0584	glycerophosphoryl diester phosphodiesterase
DS740_05160	COG0668	transmembrane transport
DS740_05165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DS740_05170	COG0726	polysaccharide deacetylase
DS740_05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS740_05180	COG1757	Na H antiporter
DS740_05185	COG0589	response to stress
DS740_05195	COG1132	(ABC) transporter
DS740_05200	COG1132	(ABC) transporter
DS740_05205	COG0702	epimerase
DS740_05225	COG0189	ligase activity
DS740_05230	COG0189	ligase activity
DS740_05235	COG4399	Belongs to the UPF0754 family
DS740_05240	COG3679	Belongs to the UPF0342 family
DS740_05245	COG4335	DNA alkylation repair
DS740_05250	COG0561	phosphatase activity
DS740_05255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DS740_05260	COG0475	glutathione-regulated potassium exporter activity
DS740_05265	COG0490	domain, Protein
DS740_05275	COG1024	Enoyl-CoA hydratase
DS740_05285	COG4152	abc transporter atp-binding protein
DS740_05290	COG1668	transmembrane transport
DS740_05295	COG0420	3'-5' exonuclease activity
DS740_05300	COG4717	serine-type aminopeptidase activity
DS740_05305	COG3481	metal-dependent phosphohydrolase, HD sub domain
DS740_05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DS740_05345	COG1846	Transcriptional regulator
DS740_05350	COG4980	gas vesicle protein
DS740_05365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DS740_05370	COG0537	adenosine 5'-monophosphoramidase activity
DS740_05375	COG1131	(ABC) transporter
DS740_05380	COG4473	ABC transporter
DS740_05390	COG1473	amidohydrolase
DS740_05395	COG3069	C4-dicarboxylate transmembrane transporter activity
DS740_05405	COG2329	Antibiotic biosynthesis monooxygenase
DS740_05410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DS740_05415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DS740_05430	COG1309	transcriptional regulator
DS740_05435	COG1511	domain protein
DS740_05440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DS740_05445	COG4377	Putative membrane peptidase family (DUF2324)
DS740_05455	COG1363	Peptidase, m42
DS740_05460	COG4405	Protein conserved in bacteria
DS740_05465	COG1301	dicarboxylic acid transport
DS740_05475	COG1234	tRNA 3'-trailer cleavage
DS740_05480	COG0095	Lipoate-protein ligase
DS740_05485	COG0702	epimerase
DS740_05490	COG0318	PFAM AMP-dependent synthetase and ligase
DS740_05500	COG0501	Belongs to the peptidase M48B family
DS740_05510	COG0456	acetyltransferase
DS740_05515	COG0604	alcohol dehydrogenase
DS740_05520	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DS740_05525	COG0406	alpha-ribazole phosphatase activity
DS740_05530	COG0183	Belongs to the thiolase family
DS740_05535	COG0318	PFAM AMP-dependent synthetase and ligase
DS740_05540	COG1268	BioY protein
DS740_05545	COG0840	transmembrane signaling receptor activity
DS740_05550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS740_05550	COG0723	plastoquinol--plastocyanin reductase activity
DS740_05555	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_05565	COG4903	ComK protein
DS740_05570	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_05580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS740_05595	COG0398	Pfam SNARE associated Golgi protein
DS740_05600	COG0681	Belongs to the peptidase S26 family
DS740_05605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DS740_05610	COG1846	Transcriptional regulator
DS740_05625	COG0738	Major facilitator superfamily
DS740_05630	COG0673	inositol 2-dehydrogenase activity
DS740_05635	COG0561	phosphatase activity
DS740_05640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DS740_05645	COG1609	Transcriptional regulator
DS740_05650	COG3180	Ammonia monooxygenase
DS740_05655	COG2814	Major facilitator Superfamily
DS740_05655	COG0477	Major facilitator Superfamily
DS740_05660	COG4533	DNA binding
DS740_05670	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DS740_05675	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DS740_05680	COG1074	ATP-dependent DNA helicase activity
DS740_05685	COG0420	3'-5' exonuclease activity
DS740_05690	COG0419	ATPase involved in DNA repair
DS740_05695	COG1403	HNH endonuclease
DS740_05735	COG5337	Spore coat protein CotH
DS740_05740	COG0179	Fumarylacetoacetate (FAA) hydrolase
DS740_05750	COG1404	Belongs to the peptidase S8 family
DS740_05760	COG0367	asparagine synthase
DS740_05765	COG2318	DinB family
DS740_05770	COG1562	ergosterol biosynthetic process
DS740_05775	COG0534	Mate efflux family protein
DS740_05780	COG2207	Transcriptional regulator
DS740_05780	COG1917	Cupin 2, conserved barrel domain protein
DS740_05785	COG1609	Transcriptional regulator
DS740_05790	COG0673	inositol 2-dehydrogenase activity
DS740_05795	COG2318	DinB family
DS740_05800	COG1279	arginine transmembrane transporter activity
DS740_05805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DS740_05810	COG1357	PFAM Pentapeptide repeats (8 copies)
DS740_05815	COG2267	carboxylic ester hydrolase activity
DS740_05820	COG0529	Catalyzes the synthesis of activated sulfate
DS740_05825	COG2046	Belongs to the sulfate adenylyltransferase family
DS740_05830	COG0175	sulfate reduction
DS740_05835	COG2045	Belongs to the ComB family
DS740_05840	COG1809	phosphosulfolactate synthase activity
DS740_05845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DS740_05850	COG4948	Mandelate Racemase Muconate Lactonizing
DS740_05855	COG2814	Major facilitator Superfamily
DS740_05860	COG0454	-acetyltransferase
DS740_05865	COG2153	protein acetylation
DS740_05870	COG0646	methionine synthase
DS740_05870	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DS740_05875	COG1666	GTP binding
DS740_05880	COG2996	Protein conserved in bacteria
DS740_05900	COG1695	Transcriptional regulator
DS740_05915	COG3227	Zinc metalloprotease (Elastase)
DS740_05920	COG1307	EDD domain protein, DegV family
DS740_05925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DS740_05940	COG0561	phosphatase activity
DS740_05945	COG1073	alpha beta
DS740_05950	COG2151	metal-sulfur cluster biosynthetic enzyme
DS740_05960	COG0277	FAD linked oxidase domain protein
DS740_05965	COG2271	Major facilitator Superfamily
DS740_05970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DS740_05985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DS740_05990	COG0505	Belongs to the CarA family
DS740_05995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DS740_06000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DS740_06015	COG2267	carboxylic ester hydrolase activity
DS740_06025	COG1744	ABC transporter substrate-binding protein PnrA-like
DS740_06040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DS740_06045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DS740_06050	COG5504	Zn-dependent protease
DS740_06055	COG0444	Belongs to the ABC transporter superfamily
DS740_06060	COG4608	Belongs to the ABC transporter superfamily
DS740_06070	COG0601	transmembrane transport
DS740_06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DS740_06085	COG0180	Tryptophanyl-tRNA synthetase
DS740_06090	COG4166	transmembrane transport
DS740_06095	COG0601	transmembrane transport
DS740_06100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DS740_06105	COG0444	Belongs to the ABC transporter superfamily
DS740_06110	COG4608	Belongs to the ABC transporter superfamily
DS740_06115	COG2814	Major facilitator Superfamily
DS740_06120	COG0456	acetyltransferase
DS740_06125	COG1393	Belongs to the ArsC family
DS740_06130	COG0861	Integral membrane protein TerC family
DS740_06135	COG4862	establishment of competence for transformation
DS740_06140	COG4469	Competence protein
DS740_06145	COG1164	Oligoendopeptidase f
DS740_06165	COG2346	COG2346, Truncated hemoglobins
DS740_06170	COG0741	lytic transglycosylase activity
DS740_06175	COG4116	CYTH
DS740_06185	COG2357	RelA SpoT domain protein
DS740_06190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DS740_06195	COG0564	pseudouridine synthase activity
DS740_06200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DS740_06205	COG0475	glutathione-regulated potassium exporter activity
DS740_06205	COG0569	domain protein
DS740_06210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DS740_06215	COG0352	thiamine-phosphate diphosphorylase activity
DS740_06220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS740_06225	COG2104	thiamine diphosphate biosynthetic process
DS740_06230	COG2022	thiamine diphosphate biosynthetic process
DS740_06235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DS740_06240	COG0351	phosphomethylpyrimidine kinase
DS740_06245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DS740_06300	COG0210	DNA helicase
DS740_06310	COG2153	protein acetylation
DS740_06315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DS740_06320	COG2382	esterase
DS740_06325	COG0626	cystathionine gamma-synthase activity
DS740_06330	COG0626	cystathionine gamma-synthase activity
DS740_06335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_06340	COG5505	Protein of unknown function (DUF819)
DS740_06355	COG2856	Zn peptidase
DS740_06365	COG1525	nuclease
DS740_06370	COG1396	sequence-specific DNA binding
DS740_06385	COG3646	Phage regulatory protein
DS740_06385	COG3645	SOS response
DS740_06430	COG3935	DnaD domain protein
DS740_06435	COG1484	DNA-dependent DNA replication
DS740_06485	COG1595	DNA-templated transcription, initiation
DS740_06520	COG5484	DNA packaging
DS740_06585	COG5280	Phage tail tape measure protein TP901
DS740_06585	COG3953	SLT domain
DS740_06590	COG1388	LysM domain
DS740_06590	COG0791	NLP P60 protein
DS740_06650	COG3409	Peptidoglycan-binding domain 1 protein
DS740_06650	COG5632	N-Acetylmuramoyl-L-alanine amidase
DS740_06670	COG5444	nuclease activity
DS740_06720	COG5444	nuclease activity
DS740_06745	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DS740_06750	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_06760	COG3711	transcriptional antiterminator
DS740_06760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_06765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_06765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DS740_06765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DS740_06770	COG1482	cell wall glycoprotein biosynthetic process
DS740_06780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_06790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DS740_06810	COG0109	protoheme IX farnesyltransferase activity
DS740_06820	COG0726	polysaccharide deacetylase
DS740_06840	COG2205	protein histidine kinase activity
DS740_06850	COG3383	formate dehydrogenase (NAD+) activity
DS740_06855	COG2427	Protein of unknown function (DUF1641)
DS740_06875	COG2124	cytochrome p450
DS740_06880	COG1819	glycosyl
DS740_06900	COG1587	Uroporphyrinogen-III synthase
DS740_06905	COG0390	transport system, permease component
DS740_06910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DS740_06915	COG0697	spore germination
DS740_06920	COG4297	protein containing double-stranded beta helix domain
DS740_06930	COG1252	NADH dehydrogenase
DS740_06935	COG1904	glucuronate isomerase
DS740_06940	COG2211	Major facilitator Superfamily
DS740_06945	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DS740_06950	COG1063	alcohol dehydrogenase
DS740_06955	COG1312	Catalyzes the dehydration of D-mannonate
DS740_06960	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_06965	COG2271	Major facilitator Superfamily
DS740_06970	COG1609	Transcriptional regulator
DS740_06975	COG0246	Mannitol dehydrogenase
DS740_06980	COG2721	sulfolactate sulfo-lyase activity
DS740_06985	COG0730	response to heat
DS740_06990	COG2318	DinB family
DS740_06995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DS740_07000	COG0457	Tetratricopeptide repeat
DS740_07010	COG2350	Protein conserved in bacteria
DS740_07015	COG5632	N-Acetylmuramoyl-L-alanine amidase
DS740_07015	COG3409	Peptidoglycan-binding domain 1 protein
DS740_07015	COG1388	LysM domain
DS740_07025	COG4195	phage-related replication protein
DS740_07030	COG3546	catalase activity
DS740_07035	COG2856	Zn peptidase
DS740_07040	COG1396	sequence-specific DNA binding
DS740_07050	COG1522	sequence-specific DNA binding
DS740_07055	COG1484	DNA-dependent DNA replication
DS740_07075	COG1595	DNA-templated transcription, initiation
DS740_07080	COG5484	DNA packaging
DS740_07080	COG3728	DNA packaging
DS740_07085	COG1783	phage Terminase large subunit
DS740_07090	COG5518	Phage portal protein
DS740_07095	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DS740_07100	COG4653	Phage capsid family
DS740_07150	COG5412	phage tail tape measure protein
DS740_07150	COG3953	SLT domain
DS740_07155	COG1652	LysM domain
DS740_07160	COG4193	domain, Protein
DS740_07170	COG3628	GPW Gp25 family protein
DS740_07175	COG3299	homolog of phage Mu protein gp47
DS740_07180	COG3778	Protein conserved in bacteria
DS740_07220	COG3409	Peptidoglycan-binding domain 1 protein
DS740_07220	COG5632	N-Acetylmuramoyl-L-alanine amidase
DS740_07235	COG0306	phosphate transporter
DS740_07240	COG1392	Phosphate transport regulator
DS740_07245	COG0531	amino acid
DS740_07250	COG0346	lactoylglutathione lyase activity
DS740_07255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DS740_07260	COG0463	Glycosyl transferase, family 2
DS740_07265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS740_07270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DS740_07275	COG2362	D-Aminopeptidase
DS740_07280	COG0601	transmembrane transport
DS740_07285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DS740_07290	COG0444	Belongs to the ABC transporter superfamily
DS740_07295	COG4166	transmembrane transport
DS740_07300	COG1619	proteins homologs of microcin C7 resistance protein MccF
DS740_07305	COG4948	Mandelate Racemase Muconate Lactonizing
DS740_07310	COG0791	NLP P60 protein
DS740_07315	COG4608	Belongs to the ABC transporter superfamily
DS740_07320	COG2706	6-phosphogluconolactonase activity
DS740_07325	COG1834	amidinotransferase
DS740_07330	COG1607	acyl-coa hydrolase
DS740_07335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DS740_07335	COG1017	nitric oxide dioxygenase activity
DS740_07345	COG2323	membrane
DS740_07350	COG2318	DinB family
DS740_07355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_07360	COG2076	Multidrug Resistance protein
DS740_07365	COG2076	Multidrug Resistance protein
DS740_07370	COG0788	formyltetrahydrofolate deformylase activity
DS740_07375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DS740_07380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DS740_07385	COG1764	response to oxidative stress
DS740_07390	COG1846	Transcriptional regulator
DS740_07395	COG1764	response to oxidative stress
DS740_07405	COG0590	tRNA wobble adenosine to inosine editing
DS740_07410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DS740_07415	COG1404	Belongs to the peptidase S8 family
DS740_07420	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_07425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DS740_07430	COG1122	ATPase activity
DS740_07435	COG4721	ABC-type cobalt transport system, permease component
DS740_07445	COG0745	RESPONSE REGULATOR receiver
DS740_07450	COG5002	protein histidine kinase activity
DS740_07450	COG3850	Histidine kinase
DS740_07455	COG3212	peptidase
DS740_07460	COG3212	peptidase
DS740_07475	COG2239	Acts as a magnesium transporter
DS740_07480	COG0789	Transcriptional regulator
DS740_07495	COG1846	Transcriptional regulator
DS740_07500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DS740_07505	COG0726	polysaccharide deacetylase
DS740_07510	COG1408	metallophosphoesterase
DS740_07520	COG0463	Glycosyl transferase, family 2
DS740_07525	COG1793	dna ligase
DS740_07525	COG3285	dna ligase
DS740_07530	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DS740_07535	COG5001	Diguanylate cyclase
DS740_07535	COG3300	MHYT domain
DS740_07540	COG0586	Pfam SNARE associated Golgi protein
DS740_07545	COG0861	Integral membrane protein TerC family
DS740_07550	COG1191	sigma factor activity
DS740_07570	COG0501	Belongs to the peptidase M48B family
DS740_07575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DS740_07590	COG3594	Acyltransferase
DS740_07595	COG5002	protein histidine kinase activity
DS740_07600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DS740_07605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DS740_07610	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DS740_07615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DS740_07620	COG0436	Aminotransferase
DS740_07625	COG1850	ribulose-bisphosphate carboxylase activity
DS740_07630	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DS740_07635	COG0235	Class ii aldolase
DS740_07640	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DS740_07645	COG3339	Conserved Protein
DS740_07660	COG3852	Histidine kinase
DS740_07665	COG1846	Transcriptional regulator
DS740_07670	COG1360	Flagellar Motor Protein
DS740_07675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DS740_07680	COG0542	response to heat
DS740_07685	COG3949	Membrane
DS740_07690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DS740_07695	COG0720	synthase
DS740_07700	COG0602	queuosine metabolic process
DS740_07705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DS740_07710	COG1733	regulation of RNA biosynthetic process
DS740_07715	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_07720	COG4641	Protein conserved in bacteria
DS740_07720	COG1388	LysM domain
DS740_07725	COG1388	LysM domain
DS740_07730	COG3858	chitin binding
DS740_07735	COG3858	chitin binding
DS740_07745	COG4873	Protein conserved in bacteria
DS740_07755	COG3773	Cell wall hydrolase
DS740_07760	COG2244	polysaccharide biosynthetic process
DS740_07765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_07770	COG2217	Heavy metal translocating P-type atpase
DS740_07780	COG0006	proline dipeptidase activity
DS740_07785	COG1609	Transcriptional regulator
DS740_07790	COG3711	transcriptional antiterminator
DS740_07795	COG1263	PTS System
DS740_07795	COG2190	(PTS) system
DS740_07795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_07800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_07805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DS740_07815	COG1533	DNA photolyase activity
DS740_07820	COG0456	acetyltransferase
DS740_07825	COG0840	transmembrane signaling receptor activity
DS740_07830	COG2084	Dehydrogenase
DS740_07835	COG4257	antibiotic catabolic process
DS740_07840	COG2340	Cysteine-rich secretory protein family
DS740_07845	COG0768	penicillin binding
DS740_07850	COG4191	Histidine kinase
DS740_07855	COG0436	Aminotransferase
DS740_07865	COG0784	Response regulator, receiver
DS740_07865	COG0835	chemotaxis
DS740_07875	COG2814	Major facilitator Superfamily
DS740_07880	COG1376	ErfK ybiS ycfS ynhG family protein
DS740_07885	COG1408	metallophosphoesterase
DS740_07890	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_07895	COG2200	EAL domain
DS740_07900	COG4703	Protein of unknown function (DUF1797)
DS740_07905	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DS740_07915	COG0517	IMP dehydrogenase activity
DS740_07920	COG0583	DNA-binding transcription factor activity
DS740_07925	COG0716	FMN binding
DS740_07935	COG0716	FMN binding
DS740_07940	COG2171	N-acyltransferase activity
DS740_07945	COG1473	amidohydrolase
DS740_07955	COG0668	transmembrane transport
DS740_07960	COG0450	alkyl hydroperoxide reductase
DS740_07965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_07980	COG0746	molybdenum cofactor guanylyltransferase activity
DS740_07985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DS740_07990	COG0303	'Molybdopterin
DS740_07995	COG1763	Mo-molybdopterin cofactor biosynthetic process
DS740_08000	COG0314	molybdopterin synthase activity
DS740_08005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DS740_08010	COG1132	(ABC) transporter
DS740_08015	COG1132	(ABC) transporter
DS740_08025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS740_08030	COG1136	(ABC) transporter
DS740_08035	COG0577	efflux transmembrane transporter activity
DS740_08040	COG1349	DNA-binding transcription factor activity
DS740_08045	COG1105	Belongs to the carbohydrate kinase PfkB family
DS740_08050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_08050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DS740_08050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DS740_08055	COG0681	Belongs to the peptidase S26 family
DS740_08065	COG0488	(ABC) transporter
DS740_08070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DS740_08075	COG2309	aminopeptidase activity
DS740_08085	COG1077	Cell shape determining protein MreB Mrl
DS740_08090	COG2002	toxin-antitoxin pair type II binding
DS740_08095	COG3852	Histidine kinase
DS740_08100	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DS740_08100	COG2105	PFAM AIG2 family protein
DS740_08105	COG0569	domain protein
DS740_08110	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DS740_08115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DS740_08125	COG0561	phosphatase activity
DS740_08130	COG0242	peptide deformylase activity
DS740_08140	COG0497	DNA recombination
DS740_08145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DS740_08150	COG0022	dehydrogenase e1 component
DS740_08155	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS740_08160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS740_08165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_08175	COG1982	Orn Lys Arg decarboxylase major
DS740_08180	COG4476	Belongs to the UPF0223 family
DS740_08185	COG4493	Belongs to the UPF0637 family
DS740_08195	COG0483	inositol monophosphate 1-phosphatase activity
DS740_08205	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DS740_08255	COG4896	Protein conserved in bacteria
DS740_08265	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DS740_08270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DS740_08275	COG2066	Belongs to the glutaminase family
DS740_08280	COG4838	Belongs to the UPF0358 family
DS740_08285	COG0772	Belongs to the SEDS family
DS740_08290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DS740_08295	COG1612	heme a metabolic process
DS740_08300	COG0109	protoheme IX farnesyltransferase activity
DS740_08305	COG2010	Cytochrome c
DS740_08305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DS740_08310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DS740_08315	COG1845	cytochrome c oxidase, subunit III
DS740_08320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DS740_08325	COG3336	cytochrome c oxidase
DS740_08335	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DS740_08340	COG2340	Cysteine-rich secretory protein family
DS740_08355	COG3679	Belongs to the UPF0342 family
DS740_08360	COG4471	UPF0298 protein
DS740_08365	COG0742	ribosomal rna small subunit methyltransferase
DS740_08370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DS740_08375	COG3314	Sporulation integral membrane protein YlbJ
DS740_08380	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS740_08385	COG3480	Lon protease (S16) C-terminal proteolytic domain
DS740_08390	COG1323	Belongs to the UPF0348 family
DS740_08400	COG1399	metal-binding, possibly nucleic acid-binding protein
DS740_08405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DS740_08415	COG0454	-acetyltransferase
DS740_08420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DS740_08425	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DS740_08430	COG2001	Belongs to the MraZ family
DS740_08435	COG0275	rRNA processing
DS740_08440	COG4839	cell division protein FtsL
DS740_08450	COG0768	penicillin binding
DS740_08455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DS740_08460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DS740_08465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DS740_08470	COG0772	Belongs to the SEDS family
DS740_08475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DS740_08480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DS740_08485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DS740_08490	COG3879	Bacterial protein of unknown function (DUF881)
DS740_08495	COG3879	Bacterial protein of unknown function (DUF881)
DS740_08500	COG3856	small basic protein
DS740_08505	COG0849	cell division
DS740_08510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DS740_08515	COG4412	M6 family metalloprotease domain protein
DS740_08515	COG1404	Belongs to the peptidase S8 family
DS740_08525	COG1191	sigma factor activity
DS740_08530	COG1191	sigma factor activity
DS740_08535	COG1119	ATPase activity
DS740_08540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DS740_08545	COG1873	PFAM PRC-barrel domain
DS740_08555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DS740_08560	COG1799	cell septum assembly
DS740_08565	COG0762	integral membrane protein
DS740_08570	COG2302	S4 RNA-binding domain
DS740_08575	COG3599	regulation of cell shape
DS740_08580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DS740_08585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DS740_08590	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DS740_08595	COG0564	pseudouridine synthase activity
DS740_08600	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DS740_08605	COG2233	PERMEase
DS740_08610	COG0540	Belongs to the ATCase OTCase family
DS740_08615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DS740_08620	COG0505	Belongs to the CarA family
DS740_08625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DS740_08630	COG0543	2 iron, 2 sulfur cluster binding
DS740_08635	COG0167	dihydroorotate dehydrogenase activity
DS740_08640	COG0284	orotidine-5'-phosphate decarboxylase activity
DS740_08645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DS740_08650	COG0175	sulfate reduction
DS740_08655	COG0306	phosphate transporter
DS740_08660	COG2046	Belongs to the sulfate adenylyltransferase family
DS740_08665	COG0529	Catalyzes the synthesis of activated sulfate
DS740_08670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DS740_08675	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DS740_08680	COG1648	precorrin-2 dehydrogenase activity
DS740_08690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DS740_08695	COG1561	YicC-like family, N-terminal region
DS740_08700	COG2052	Domain of unknown function (DUF370)
DS740_08705	COG0194	GDP metabolic process
DS740_08710	COG1758	RNA polymerase activity
DS740_08715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DS740_08720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DS740_08725	COG0242	peptide deformylase activity
DS740_08730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DS740_08735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DS740_08735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DS740_08740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DS740_08745	COG0631	protein serine/threonine phosphatase activity
DS740_08750	COG0515	serine threonine protein kinase
DS740_08750	COG2815	serine threonine protein kinase
DS740_08755	COG1162	GTPase activity
DS740_08760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DS740_08765	COG1564	THIamine pyrophosphokinase
DS740_08775	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DS740_08780	COG1302	Protein conserved in bacteria
DS740_08785	COG1461	Dihydroxyacetone kinase
DS740_08790	COG1760	l-serine dehydratase
DS740_08795	COG1760	l-serine dehydratase
DS740_08800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DS740_08805	COG1349	DNA-binding transcription factor activity
DS740_08805	COG2050	protein possibly involved in aromatic compounds catabolism
DS740_08810	COG0416	fatty acid biosynthetic process
DS740_08815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DS740_08820	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_08825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS740_08830	COG0571	ribonuclease III activity
DS740_08835	COG1196	nuclear chromosome segregation
DS740_08840	COG0552	protein localization to endoplasmic reticulum
DS740_08850	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DS740_08855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DS740_08860	COG0228	four-way junction DNA binding
DS740_08865	COG1837	Belongs to the UPF0109 family
DS740_08875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DS740_08880	COG0336	Belongs to the RNA methyltransferase TrmD family
DS740_08885	COG0335	large ribosomal subunit rRNA binding
DS740_08890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DS740_08895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DS740_08905	COG2257	FlhB HrpN YscU SpaS Family
DS740_08910	COG0045	succinate-CoA ligase (ADP-forming) activity
DS740_08915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DS740_08920	COG0758	DNA mediated transformation
DS740_08925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DS740_08930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DS740_08935	COG4974	Belongs to the 'phage' integrase family
DS740_08940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DS740_08945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DS740_08950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DS740_08955	COG1815	bacterial-type flagellum-dependent cell motility
DS740_08960	COG1558	bacterial-type flagellum-dependent cell motility
DS740_08965	COG1677	Flagellar hook-basal body complex protein FliE
DS740_08970	COG1766	The M ring may be actively involved in energy transduction
DS740_08975	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DS740_08980	COG1317	bacterial-type flagellum organization
DS740_08985	COG1157	protein secretion by the type III secretion system
DS740_08990	COG2882	bacterial-type flagellum organization
DS740_08995	COG3334	PFAM MgtE intracellular
DS740_09000	COG3144	bacterial-type flagellum assembly
DS740_09005	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DS740_09010	COG4786	Flagellar basal body rod
DS740_09015	COG1582	Flagellar protein (FlbD)
DS740_09020	COG1580	Controls the rotational direction of flagella during chemotaxis
DS740_09025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DS740_09030	COG1776	CheC inhibitor of MCP methylation
DS740_09030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DS740_09035	COG2201	protein-glutamate methylesterase activity
DS740_09040	COG3190	flagellar
DS740_09045	COG1338	Plays a role in the flagellum-specific transport system
DS740_09050	COG1987	bacterial-type flagellum assembly
DS740_09055	COG1684	flagellar biosynthetic protein fliR
DS740_09060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DS740_09065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DS740_09070	COG1419	protein localization to endoplasmic reticulum
DS740_09075	COG0455	bacterial-type flagellum organization
DS740_09080	COG2201	protein-glutamate methylesterase activity
DS740_09085	COG0643	Histidine kinase
DS740_09085	COG2198	Histidine kinase
DS740_09090	COG0835	chemotaxis
DS740_09095	COG1776	CheC inhibitor of MCP methylation
DS740_09100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DS740_09105	COG1191	sigma factor activity
DS740_09115	COG0052	Belongs to the universal ribosomal protein uS2 family
DS740_09120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DS740_09125	COG0528	UMP kinase activity
DS740_09130	COG0233	cytoplasmic translational termination
DS740_09135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DS740_09140	COG4589	Belongs to the CDS family
DS740_09145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DS740_09150	COG0750	zinc metalloprotease
DS740_09155	COG0442	prolyl-tRNA aminoacylation
DS740_09160	COG2176	DNA-directed DNA polymerase activity
DS740_09185	COG0779	Required for maturation of 30S ribosomal subunits
DS740_09190	COG0195	Participates in both transcription termination and antitermination
DS740_09195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DS740_09200	COG1358	cellular component organization or biogenesis
DS740_09205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DS740_09210	COG1550	Protein conserved in bacteria
DS740_09215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DS740_09220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DS740_09225	COG0196	riboflavin kinase activity
DS740_09230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DS740_09235	COG1185	polyribonucleotide nucleotidyltransferase activity
DS740_09240	COG0726	polysaccharide deacetylase
DS740_09245	COG0612	Peptidase, M16
DS740_09250	COG1873	PFAM PRC-barrel domain
DS740_09255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DS740_09260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DS740_09265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DS740_09270	COG0527	aspartate kinase activity
DS740_09275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DS740_09280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DS740_09285	COG0740	serine-type endopeptidase activity
DS740_09295	COG4980	gas vesicle protein
DS740_09295	COG1674	ftsk spoiiie
DS740_09300	COG2188	Transcriptional regulator
DS740_09305	COG2814	Major facilitator Superfamily
DS740_09310	COG0612	Peptidase, M16
DS740_09315	COG0612	Peptidase, M16
DS740_09320	COG0300	oxidoreductase activity
DS740_09335	COG1426	Protein conserved in bacteria
DS740_09340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DS740_09345	COG1546	Belongs to the CinA family
DS740_09345	COG1058	Belongs to the CinA family
DS740_09350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DS740_09355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS740_09360	COG1418	mRNA catabolic process
DS740_09365	COG1692	metallophosphoesterase
DS740_09370	COG2359	stage V sporulation protein S
DS740_09375	COG1063	alcohol dehydrogenase
DS740_09380	COG0156	8-amino-7-oxononanoate synthase activity
DS740_09385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DS740_09390	COG4550	Control of competence regulator ComK, YlbF/YmcA
DS740_09400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DS740_09405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DS740_09420	COG3226	Transcriptional regulator
DS740_09425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_09435	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DS740_09440	COG3321	synthase
DS740_09445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DS740_09445	COG2070	2-Nitropropane dioxygenase
DS740_09450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS740_09455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DS740_09460	COG3425	synthase
DS740_09465	COG1024	Enoyl-CoA hydratase
DS740_09470	COG1024	Enoyl-CoA hydratase
DS740_09475	COG0318	PFAM AMP-dependent synthetase and ligase
DS740_09475	COG0300	oxidoreductase activity
DS740_09475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_09475	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_09475	COG3321	synthase
DS740_09480	COG3321	synthase
DS740_09480	COG0300	oxidoreductase activity
DS740_09480	COG4221	oxidoreductase activity
DS740_09480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS740_09485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_09485	COG3321	synthase
DS740_09485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS740_09485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS740_09485	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_09490	COG4221	oxidoreductase activity
DS740_09490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_09490	COG3321	synthase
DS740_09490	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_09495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS740_09495	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DS740_09495	COG3321	synthase
DS740_09495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DS740_09500	COG2124	cytochrome p450
DS740_09510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_09515	COG1404	Belongs to the peptidase S8 family
DS740_09525	COG4195	phage-related replication protein
DS740_09530	COG1764	response to oxidative stress
DS740_09535	COG2076	Multidrug Resistance protein
DS740_09540	COG2076	Multidrug Resistance protein
DS740_09555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DS740_09560	COG1923	regulation of RNA biosynthetic process
DS740_09575	COG1780	Probably involved in ribonucleotide reductase function
DS740_09580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS740_09585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS740_09590	COG4112	unkown
DS740_09595	COG0860	N-Acetylmuramoyl-L-alanine amidase
DS740_09605	COG0464	growth
DS740_09610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DS740_09615	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DS740_09620	COG0789	Transcriptional regulator
DS740_09625	COG0174	glutamine synthetase
DS740_09650	COG4282	regulation of fungal-type cell wall biogenesis
DS740_09660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_09690	COG0135	phosphoribosylanthranilate isomerase activity
DS740_09695	COG2211	Major facilitator Superfamily
DS740_09700	COG3507	Belongs to the glycosyl hydrolase 43 family
DS740_09705	COG1940	carbohydrate kinase activity
DS740_09710	COG2115	Belongs to the xylose isomerase family
DS740_09715	COG1070	Carbohydrate kinase
DS740_09730	COG2814	Major facilitator Superfamily
DS740_09735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DS740_09750	COG0756	dUTP diphosphatase activity
DS740_09785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DS740_09795	COG3832	glyoxalase III activity
DS740_09805	COG0697	spore germination
DS740_09810	COG0531	amino acid
DS740_09840	COG4195	phage-related replication protein
DS740_09850	COG0346	lactoylglutathione lyase activity
DS740_09860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DS740_09865	COG1388	LysM domain
DS740_09870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DS740_09875	COG4224	UPF0291 protein
DS740_09880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DS740_09890	COG3763	UPF0154 protein
DS740_09900	COG0785	Cytochrome C biogenesis protein
DS740_09905	COG2201	protein-glutamate methylesterase activity
DS740_09910	COG4846	Membrane protein involved in cytochrome C biogenesis
DS740_09920	COG0071	Belongs to the small heat shock protein (HSP20) family
DS740_09935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DS740_09940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_09960	COG0824	Thioesterase
DS740_09970	COG4841	protein insertion into membrane
DS740_09975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DS740_09980	COG1832	CoA-binding protein
DS740_09985	COG0187	DNA topoisomerase II activity
DS740_09990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DS740_10000	COG1115	amino acid carrier protein
DS740_10005	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DS740_10015	COG5520	Belongs to the glycosyl hydrolase 30 family
DS740_10020	COG3507	Belongs to the glycosyl hydrolase 43 family
DS740_10025	COG2246	polysaccharide biosynthetic process
DS740_10030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DS740_10035	COG0586	Pfam SNARE associated Golgi protein
DS740_10040	COG2404	hydrolase activity, acting on ester bonds
DS740_10045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DS740_10050	COG1024	Enoyl-CoA hydratase
DS740_10055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DS740_10060	COG0511	ligase activity, forming carbon-carbon bonds
DS740_10065	COG0439	Biotin carboxylase
DS740_10070	COG0318	PFAM AMP-dependent synthetase and ligase
DS740_10075	COG1960	acyl-CoA dehydrogenase activity
DS740_10085	COG1649	PFAM Uncharacterised BCR, COG1649
DS740_10095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_10095	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DS740_10100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_10105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_10110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_10115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_10120	COG2027	D-alanyl-D-alanine carboxypeptidase
DS740_10125	COG2017	converts alpha-aldose to the beta-anomer
DS740_10130	COG0534	Mate efflux family protein
DS740_10145	COG0582	viral genome integration into host DNA
DS740_10150	COG0166	Belongs to the GPI family
DS740_10155	COG0405	Gamma-glutamyltransferase
DS740_10160	COG0583	DNA-binding transcription factor activity
DS740_10170	COG0493	'glutamate synthase
DS740_10175	COG0069	glutamate synthase activity
DS740_10175	COG0067	glutamate synthase
DS740_10175	COG0070	glutamate synthase
DS740_10180	COG0583	DNA-binding transcription factor activity
DS740_10185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DS740_10190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DS740_10200	COG0300	oxidoreductase activity
DS740_10205	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DS740_10215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DS740_10230	COG1131	(ABC) transporter
DS740_10240	COG2814	Major facilitator Superfamily
DS740_10245	COG1070	Carbohydrate kinase
DS740_10250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS740_10255	COG0243	molybdopterin cofactor binding
DS740_10265	COG2814	Major facilitator Superfamily
DS740_10270	COG0673	inositol 2-dehydrogenase activity
DS740_10275	COG1082	Xylose isomerase domain protein TIM barrel
DS740_10280	COG1609	Transcriptional regulator
DS740_10300	COG5278	phosphoserine phosphatase activity
DS740_10300	COG0840	transmembrane signaling receptor activity
DS740_10305	COG2368	4-hydroxyphenylacetate
DS740_10310	COG4305	rare lipoprotein A
DS740_10315	COG3619	membrane
DS740_10320	COG3866	Pectate lyase
DS740_10325	COG2135	peptidase activity
DS740_10335	COG2140	Oxalate decarboxylase
DS740_10355	COG2720	vancomycin resistance protein
DS740_10370	COG3739	integral membrane protein
DS740_10375	COG0583	DNA-binding transcription factor activity
DS740_10380	COG0697	spore germination
DS740_10390	COG0693	protein deglycase activity
DS740_10395	COG2367	Beta-lactamase
DS740_10415	COG0574	Belongs to the PEP-utilizing enzyme family
DS740_10415	COG3848	Pyruvate phosphate dikinase
DS740_10420	COG0726	polysaccharide deacetylase
DS740_10430	COG2314	TM2 domain
DS740_10460	COG3655	Transcriptional regulator
DS740_10495	COG0457	Tetratricopeptide repeat
DS740_10505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS740_10515	COG4282	regulation of fungal-type cell wall biogenesis
DS740_10520	COG1231	oxidoreductase activity
DS740_10525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS740_10530	COG2207	Transcriptional regulator
DS740_10530	COG0662	Cupin 2, conserved barrel domain protein
DS740_10535	COG0456	acetyltransferase
DS740_10540	COG1309	transcriptional regulator
DS740_10545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_10550	COG3708	Transcriptional regulator
DS740_10555	COG2378	regulation of single-species biofilm formation
DS740_10565	COG0640	Transcriptional regulator
DS740_10570	COG0741	lytic transglycosylase activity
DS740_10575	COG2322	membrane
DS740_10590	COG1619	proteins homologs of microcin C7 resistance protein MccF
DS740_10595	COG3239	Fatty acid desaturase
DS740_10600	COG4585	Histidine kinase
DS740_10605	COG2197	response regulator
DS740_10610	COG1388	LysM domain
DS740_10610	COG3584	3D domain protein
DS740_10615	COG0514	ATP-dependent DNA helicase (RecQ)
DS740_10630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DS740_10635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DS740_10650	COG0071	Belongs to the small heat shock protein (HSP20) family
DS740_10675	COG1012	belongs to the aldehyde dehydrogenase family
DS740_10680	COG1657	PFAM Prenyltransferase squalene oxidase
DS740_10685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DS740_10690	COG0733	neurotransmitter:sodium symporter activity
DS740_10695	COG0385	Bile acid
DS740_10700	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS740_10705	COG0567	Dehydrogenase, E1 component
DS740_10710	COG4548	von Willebrand factor, type A
DS740_10715	COG0714	Associated with various cellular activities
DS740_10720	COG2032	superoxide dismutase activity
DS740_10725	COG1388	LysM domain
DS740_10725	COG0791	NLP P60 protein
DS740_10730	COG1819	glycosyl
DS740_10735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DS740_10740	COG0534	Mate efflux family protein
DS740_10745	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_10750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DS740_10755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DS740_10765	COG2962	Rard protein
DS740_10780	COG2610	gluconate transmembrane transporter activity
DS740_10785	COG1942	4-Oxalocrotonate Tautomerase
DS740_10790	COG1733	regulation of RNA biosynthetic process
DS740_10795	COG0778	Nitroreductase
DS740_10800	COG0400	carboxylic ester hydrolase activity
DS740_10805	COG0346	lactoylglutathione lyase activity
DS740_10815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS740_10820	COG3409	Peptidoglycan-binding domain 1 protein
DS740_10820	COG0793	Belongs to the peptidase S41A family
DS740_10825	COG2226	methyltransferase
DS740_10835	COG1876	peptidase activity
DS740_10840	COG0813	purine-nucleoside phosphorylase activity
DS740_10855	COG0671	phosphoesterase, PA-phosphatase related
DS740_10875	COG4479	Belongs to the UPF0346 family
DS740_10885	COG1509	lysine 2,3-aminomutase activity
DS740_10890	COG0456	acetyltransferase
DS740_10895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DS740_10900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DS740_10905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DS740_10910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DS740_10920	COG0456	acetyltransferase
DS740_10925	COG0463	Glycosyl transferase, family 2
DS740_10940	COG4641	Protein conserved in bacteria
DS740_10945	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
DS740_10950	COG1086	Polysaccharide biosynthesis protein
DS740_10955	COG3331	DNA recombination
DS740_11010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DS740_11045	COG0756	dUTP diphosphatase activity
DS740_11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_11055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS740_11065	COG1372	Participates in initiation and elongation during chromosome replication
DS740_11065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS740_11070	COG1780	Probably involved in ribonucleotide reductase function
DS740_11145	COG0270	DNA (cytosine-5-)-methyltransferase activity
DS740_11160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DS740_11185	COG3584	3D domain protein
DS740_11190	COG0587	DNA-directed DNA polymerase activity
DS740_11195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DS740_11200	COG0358	DNA primase activity
DS740_11205	COG0305	Participates in initiation and elongation during chromosome replication
DS740_11215	COG2887	Belongs to the helicase family. UvrD subfamily
DS740_11255	COG2135	peptidase activity
DS740_11260	COG1793	dna ligase
DS740_11305	COG1388	LysM domain
DS740_11320	COG3645	SOS response
DS740_11320	COG3646	Phage regulatory protein
DS740_11365	COG3655	Transcriptional regulator
DS740_11380	COG0582	viral genome integration into host DNA
DS740_11465	COG3655	Transcriptional regulator
DS740_11535	COG0776	regulation of translation
DS740_11570	COG4373	Mu-like prophage FluMu protein gp28
DS740_11670	COG0582	viral genome integration into host DNA
DS740_11695	COG1196	nuclear chromosome segregation
DS740_11695	COG0739	heme binding
DS740_11695	COG0741	lytic transglycosylase activity
DS740_11705	COG2433	Pfam Transposase IS66
DS740_11715	COG5434	Belongs to the glycosyl hydrolase 28 family
DS740_11715	COG4632	Exopolysaccharide biosynthesis protein
DS740_11725	COG5632	N-Acetylmuramoyl-L-alanine amidase
DS740_11740	COG0457	Tetratricopeptide repeat
DS740_11750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS740_11775	COG5444	nuclease activity
DS740_11780	COG4282	regulation of fungal-type cell wall biogenesis
DS740_11790	COG1525	nuclease
DS740_11810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DS740_11815	COG1086	Polysaccharide biosynthesis protein
DS740_11820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DS740_11825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DS740_11830	COG1846	Transcriptional regulator
DS740_11835	COG0534	Mate efflux family protein
DS740_11845	COG4698	Protein conserved in bacteria
DS740_11850	COG2755	lipolytic protein G-D-S-L family
DS740_11855	COG1999	signal sequence binding
DS740_11865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DS740_11870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DS740_11875	COG1272	protein, Hemolysin III
DS740_11880	COG0204	Acyl-transferase
DS740_11885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DS740_11890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DS740_11900	COG2136	Putative SAM-dependent methyltransferase
DS740_11900	COG2521	methyltransferase
DS740_11910	COG0129	dihydroxy-acid dehydratase activity
DS740_11915	COG1413	lyase activity
DS740_11920	COG1418	mRNA catabolic process
DS740_11925	COG0386	Belongs to the glutathione peroxidase family
DS740_11930	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DS740_11935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DS740_11940	COG1278	Cold shock
DS740_11960	COG0328	RNA-DNA hybrid ribonuclease activity
DS740_11965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DS740_11970	COG0328	RNA-DNA hybrid ribonuclease activity
DS740_11980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS740_11995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DS740_12005	COG1755	Isoprenylcysteine carboxyl methyltransferase
DS740_12010	COG3424	synthase
DS740_12015	COG2233	PERMEase
DS740_12020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DS740_12025	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DS740_12035	COG0800	Aldolase
DS740_12040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS740_12045	COG1609	Transcriptional regulator
DS740_12050	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DS740_12055	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_12060	COG1199	ATP-dependent helicase activity
DS740_12075	COG0116	Belongs to the methyltransferase superfamily
DS740_12090	COG4474	Belongs to the UPF0398 family
DS740_12100	COG3359	exonuclease
DS740_12105	COG1205	dead DEAH box helicase
DS740_12105	COG1111	helicase
DS740_12110	COG2190	(PTS) system
DS740_12115	COG0071	Belongs to the small heat shock protein (HSP20) family
DS740_12150	COG3331	DNA recombination
DS740_12155	COG4499	WXG100 protein secretion system (Wss), protein YukC
DS740_12155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DS740_12165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DS740_12170	COG3935	DnaD domain protein
DS740_12175	COG0017	Asparaginyl-tRNA synthetase
DS740_12180	COG0436	Aminotransferase
DS740_12185	COG5353	protein conserved in bacteria
DS740_12195	COG1199	ATP-dependent helicase activity
DS740_12195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DS740_12200	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DS740_12205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DS740_12210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DS740_12215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DS740_12215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DS740_12220	COG0617	tRNA 3'-terminal CCA addition
DS740_12225	COG0438	transferase activity, transferring glycosyl groups
DS740_12230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DS740_12235	COG1803	Methylglyoxal synthase
DS740_12240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DS740_12245	COG1694	Mazg nucleotide pyrophosphohydrolase
DS740_12250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DS740_12260	COG4347	Protein of unknown function (DUF1405)
DS740_12265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DS740_12265	COG2010	Cytochrome c
DS740_12270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DS740_12275	COG0723	plastoquinol--plastocyanin reductase activity
DS740_12285	COG5582	Belongs to the UPF0302 family
DS740_12290	COG0457	Tetratricopeptide repeat
DS740_12295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DS740_12300	COG0287	Prephenate dehydrogenase
DS740_12305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DS740_12315	COG0133	tryptophan synthase activity
DS740_12320	COG0135	phosphoribosylanthranilate isomerase activity
DS740_12330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DS740_12335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DS740_12340	COG4401	Chorismate mutase type I
DS740_12345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DS740_12350	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DS740_12355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DS740_12360	COG0105	UTP biosynthetic process
DS740_12365	COG0142	geranyltranstransferase activity
DS740_12370	COG2226	methyltransferase
DS740_12375	COG0142	geranyltranstransferase activity
DS740_12385	COG0302	gtp cyclohydrolase
DS740_12390	COG0776	regulation of translation
DS740_12395	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DS740_12410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DS740_12415	COG1160	GTP binding
DS740_12440	COG1304	FMN binding
DS740_12445	COG0539	negative regulation of cytoplasmic translation
DS740_12450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DS740_12460	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DS740_12465	COG2959	enzyme of heme biosynthesis
DS740_12470	COG3409	Peptidoglycan-binding domain 1 protein
DS740_12470	COG3773	Cell wall hydrolase
DS740_12475	COG2339	peptidase activity
DS740_12480	COG0492	ferredoxin-NADP+ reductase activity
DS740_12485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS740_12490	COG4862	establishment of competence for transformation
DS740_12495	COG1408	metallophosphoesterase
DS740_12505	COG1388	LysM domain
DS740_12510	COG1266	CAAX protease self-immunity
DS740_12515	COG0514	ATP-dependent DNA helicase (RecQ)
DS740_12520	COG4955	Helix-turn-helix domain
DS740_12525	COG1141	Ferredoxin
DS740_12530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DS740_12535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DS740_12540	COG0710	3-dehydroquinate dehydratase activity
DS740_12550	COG1595	DNA-templated transcription, initiation
DS740_12555	COG5002	protein histidine kinase activity
DS740_12560	COG0745	RESPONSE REGULATOR receiver
DS740_12565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS740_12570	COG1333	cytochrome c biogenesis protein
DS740_12575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_12580	COG1187	pseudouridine synthase activity
DS740_12585	COG0700	Nucleoside recognition
DS740_12590	COG2715	membrane protein required for spore maturation
DS740_12595	COG1686	Belongs to the peptidase S11 family
DS740_12605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DS740_12610	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DS740_12615	COG1547	Domain of unknown function (DUF309)
DS740_12620	COG0456	acetyltransferase
DS740_12625	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DS740_12630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DS740_12630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DS740_12635	COG0307	riboflavin synthase, alpha
DS740_12640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS740_12640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DS740_12650	COG0681	Belongs to the peptidase S26 family
DS740_12665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DS740_12675	COG4086	secreted protein
DS740_12680	COG0019	diaminopimelate decarboxylase activity
DS740_12685	COG0697	spore germination
DS740_12700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DS740_12720	COG1191	sigma factor activity
DS740_12725	COG2172	sigma factor antagonist activity
DS740_12730	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_12735	COG1686	Belongs to the peptidase S11 family
DS740_12740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DS740_12745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DS740_12750	COG4974	Belongs to the 'phage' integrase family
DS740_12760	COG0735	belongs to the Fur family
DS740_12765	COG1300	Membrane
DS740_12775	COG0281	malic enzyme
DS740_12780	COG1757	Na H antiporter
DS740_12785	COG1027	Aspartate ammonia-lyase
DS740_12790	COG0252	asparaginase activity
DS740_12795	COG1396	sequence-specific DNA binding
DS740_12800	COG1379	DNA repair
DS740_12805	COG0494	nUDIX hydrolase
DS740_12815	COG0667	Aldo Keto reductase
DS740_12825	COG1073	alpha beta
DS740_12835	COG4918	Iron-sulphur cluster biosynthesis
DS740_12840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DS740_12840	COG0456	acetyltransferase
DS740_12845	COG2329	Antibiotic biosynthesis monooxygenase
DS740_12850	COG0456	acetyltransferase
DS740_12860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS740_12870	COG2211	Major facilitator Superfamily
DS740_12880	COG0346	lactoylglutathione lyase activity
DS740_12885	COG1072	(Pantothenic acid kinase))
DS740_12890	COG3048	D-serine ammonia-lyase activity
DS740_12895	COG0300	oxidoreductase activity
DS740_12900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_12905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DS740_12910	COG4187	Peptidase family M20/M25/M40
DS740_12915	COG1902	pentaerythritol trinitrate reductase activity
DS740_12920	COG0596	Alpha beta hydrolase
DS740_12930	COG1234	tRNA 3'-trailer cleavage
DS740_12935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DS740_12940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DS740_12945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DS740_12955	COG0706	membrane insertase activity
DS740_12960	COG3361	conserved protein (COG2071)
DS740_12965	COG2195	Cleaves the N-terminal amino acid of tripeptides
DS740_12970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DS740_12975	COG0346	lactoylglutathione lyase activity
DS740_12980	COG1376	ErfK ybiS ycfS ynhG family protein
DS740_12985	COG4129	membrane
DS740_12990	COG1126	abc transporter atp-binding protein
DS740_12995	COG0765	amino acid transport
DS740_13000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS740_13010	COG1597	lipid kinase activity
DS740_13015	COG2814	Major facilitator Superfamily
DS740_13020	COG4978	Transcriptional regulator
DS740_13020	COG0789	Transcriptional regulator
DS740_13025	COG0508	dehydrogenase complex catalyzes the overall conversion of
DS740_13030	COG0022	dehydrogenase e1 component
DS740_13035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DS740_13040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DS740_13045	COG3426	butyrate kinase activity
DS740_13050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS740_13055	COG0280	phosphate acetyltransferase
DS740_13060	COG3290	protein histidine kinase activity
DS740_13060	COG3829	transcription factor binding
DS740_13070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DS740_13075	COG2079	MmgE PrpD family protein
DS740_13080	COG0372	Belongs to the citrate synthase family
DS740_13085	COG1960	acyl-CoA dehydrogenase activity
DS740_13090	COG1250	3-hydroxyacyl-CoA dehydrogenase
DS740_13095	COG0183	Belongs to the thiolase family
DS740_13100	COG0584	glycerophosphoryl diester phosphodiesterase
DS740_13105	COG0860	N-Acetylmuramoyl-L-alanine amidase
DS740_13115	COG1902	pentaerythritol trinitrate reductase activity
DS740_13120	COG0745	RESPONSE REGULATOR receiver
DS740_13125	COG0750	zinc metalloprotease
DS740_13130	COG0497	DNA recombination
DS740_13135	COG1438	arginine binding
DS740_13140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DS740_13145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DS740_13150	COG0142	geranyltranstransferase activity
DS740_13155	COG1722	exodeoxyribonuclease VII activity
DS740_13160	COG1570	exodeoxyribonuclease VII activity
DS740_13165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DS740_13170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DS740_13175	COG1302	Protein conserved in bacteria
DS740_13180	COG0439	Biotin carboxylase
DS740_13185	COG0511	ligase activity, forming carbon-carbon bonds
DS740_13225	COG3854	ATPases associated with a variety of cellular activities
DS740_13235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DS740_13240	COG0006	proline dipeptidase activity
DS740_13245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DS740_13255	COG3872	metal-dependent enzyme
DS740_13265	COG1752	Esterase of the alpha-beta hydrolase superfamily
DS740_13270	COG1321	iron dependent repressor
DS740_13275	COG0095	Lipoate-protein ligase
DS740_13280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS740_13285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DS740_13290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DS740_13295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DS740_13300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DS740_13315	COG1396	sequence-specific DNA binding
DS740_13325	COG0681	Belongs to the peptidase S26 family
DS740_13350	COG4940	Competence protein ComGF
DS740_13360	COG4970	Tfp pilus assembly protein FimT
DS740_13365	COG4537	Required for transformation and DNA binding
DS740_13370	COG1459	type II secretion system
DS740_13375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DS740_13385	COG0598	Magnesium transport protein CorA
DS740_13390	COG1253	flavin adenine dinucleotide binding
DS740_13395	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_13405	COG1393	Belongs to the ArsC family
DS740_13415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_13425	COG0011	TIGRFAM Protein of
DS740_13435	COG2866	Carboxypeptidase
DS740_13440	COG1368	sulfuric ester hydrolase activity
DS740_13445	COG1940	carbohydrate kinase activity
DS740_13450	COG4483	Protein conserved in bacteria
DS740_13455	COG0457	Tetratricopeptide repeat
DS740_13455	COG0705	Rhomboid family
DS740_13465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DS740_13470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DS740_13475	COG0438	transferase activity, transferring glycosyl groups
DS740_13490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DS740_13495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DS740_13500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DS740_13505	COG0581	inorganic phosphate transmembrane transporter activity
DS740_13510	COG0573	inorganic phosphate transmembrane transporter activity
DS740_13515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DS740_13525	COG0477	Major facilitator Superfamily
DS740_13530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DS740_13535	COG2839	Protein conserved in bacteria
DS740_13540	COG5521	maltodextrose utilization protein MalA
DS740_13545	COG1388	LysM domain
DS740_13550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DS740_13555	COG4709	membrane
DS740_13560	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DS740_13565	COG0735	belongs to the Fur family
DS740_13570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DS740_13580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DS740_13585	COG0513	Belongs to the DEAD box helicase family
DS740_13595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DS740_13600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DS740_13605	COG2384	SAM-dependent methyltransferase
DS740_13610	COG2010	Cytochrome c
DS740_13620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DS740_13625	COG0358	DNA primase activity
DS740_13630	COG1671	Belongs to the UPF0178 family
DS740_13635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DS740_13640	COG0517	IMP dehydrogenase activity
DS740_13645	COG0751	glycine-tRNA ligase activity
DS740_13650	COG0752	glycyl-tRNA synthetase alpha subunit
DS740_13655	COG1381	Involved in DNA repair and RecF pathway recombination
DS740_13665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DS740_13670	COG0295	cytidine deaminase activity
DS740_13675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DS740_13680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DS740_13685	COG1480	7TM receptor with intracellular HD hydrolase
DS740_13690	COG1702	phosphate starvation-inducible protein PhoH
DS740_13695	COG0561	phosphatase activity
DS740_13710	COG4864	UPF0365 protein
DS740_13715	COG1030	water channel activity
DS740_13720	COG1610	YqeY-like protein
DS740_13725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DS740_13730	COG1283	sodium-dependent phosphate transmembrane transporter activity
DS740_13735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DS740_13740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DS740_13745	COG2264	protein methyltransferase activity
DS740_13750	COG0484	heat shock protein binding
DS740_13755	COG0443	Heat shock 70 kDa protein
DS740_13760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DS740_13765	COG1420	regulation of RNA biosynthetic process
DS740_13770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DS740_13775	COG0481	GTPase activity
DS740_13785	COG0860	N-Acetylmuramoyl-L-alanine amidase
DS740_13790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DS740_13795	COG0268	Binds directly to 16S ribosomal RNA
DS740_13800	COG1466	dna polymerase III delta subunit
DS740_13810	COG2333	competence protein COMEC
DS740_13810	COG0658	competence protein
DS740_13815	COG2131	deaminase
DS740_13820	COG1596	polysaccharide export
DS740_13820	COG1555	photosystem II stabilization
DS740_13825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DS740_13830	COG2226	methyltransferase
DS740_13835	COG0799	negative regulation of ribosome biogenesis
DS740_13840	COG1713	HD superfamily hydrolase involved in NAD metabolism
DS740_13845	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DS740_13850	COG1534	Rna-binding protein
DS740_13855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DS740_13860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DS740_13865	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DS740_13875	COG2755	lipolytic protein G-D-S-L family
DS740_13880	COG5632	N-Acetylmuramoyl-L-alanine amidase
DS740_13880	COG3409	Peptidoglycan-binding domain 1 protein
DS740_13885	COG0398	Pfam SNARE associated Golgi protein
DS740_13900	COG3209	COG3209 Rhs family protein
DS740_13910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DS740_13920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DS740_13925	COG0798	PFAM Bile acid sodium symporter
DS740_13930	COG0346	lactoylglutathione lyase activity
DS740_13935	COG0640	Transcriptional regulator
DS740_13940	COG3403	YqcI/YcgG family
DS740_13945	COG0457	Tetratricopeptide repeat
DS740_13960	COG5444	nuclease activity
DS740_13980	COG3409	Peptidoglycan-binding domain 1 protein
DS740_13980	COG5632	N-Acetylmuramoyl-L-alanine amidase
DS740_13985	COG4824	toxin secretion phage lysis holin
DS740_14015	COG3778	Protein conserved in bacteria
DS740_14020	COG3299	homolog of phage Mu protein gp47
DS740_14025	COG3628	GPW Gp25 family protein
DS740_14035	COG4193	domain, Protein
DS740_14040	COG1652	LysM domain
DS740_14045	COG3953	SLT domain
DS740_14045	COG5280	Phage tail tape measure protein TP901
DS740_14110	COG4653	Phage capsid family
DS740_14115	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DS740_14125	COG2369	cell adhesion
DS740_14130	COG5518	Phage portal protein
DS740_14135	COG1783	phage Terminase large subunit
DS740_14140	COG5484	DNA packaging
DS740_14150	COG3677	Transposase
DS740_14165	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
DS740_14175	COG1484	DNA-dependent DNA replication
DS740_14180	COG3935	DnaD domain protein
DS740_14185	COG3723	Recombinational DNA repair protein, rece pathway
DS740_14190	COG5377	YqaJ viral recombinase family
DS740_14215	COG1476	TRANSCRIPTIONal
DS740_14220	COG3620	sequence-specific DNA binding
DS740_14230	COG0563	adenylate kinase activity
DS740_14235	COG2856	Zn peptidase
DS740_14245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DS740_14255	COG3223	Belongs to the PsiE family
DS740_14260	COG5002	protein histidine kinase activity
DS740_14260	COG0642	Histidine kinase
DS740_14265	COG0745	RESPONSE REGULATOR receiver
DS740_14270	COG2311	Membrane
DS740_14275	COG0454	-acetyltransferase
DS740_14280	COG2249	NAD(P)H dehydrogenase (quinone) activity
DS740_14290	COG0730	response to heat
DS740_14295	COG0425	Belongs to the sulfur carrier protein TusA family
DS740_14300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS740_14300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_14310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS740_14310	COG0425	Belongs to the sulfur carrier protein TusA family
DS740_14320	COG2210	Belongs to the sulfur carrier protein TusA family
DS740_14325	COG1937	Protein conserved in bacteria
DS740_14340	COG0662	Cupin 2, conserved barrel domain protein
DS740_14355	COG4978	Transcriptional regulator
DS740_14355	COG0789	Transcriptional regulator
DS740_14360	COG2814	Major facilitator Superfamily
DS740_14365	COG0456	acetyltransferase
DS740_14370	COG1253	flavin adenine dinucleotide binding
DS740_14380	COG0697	spore germination
DS740_14385	COG0583	DNA-binding transcription factor activity
DS740_14390	COG2072	flavoprotein involved in K transport
DS740_14395	COG1230	cation diffusion facilitator family transporter
DS740_14400	COG1942	4-Oxalocrotonate Tautomerase
DS740_14405	COG0583	DNA-binding transcription factor activity
DS740_14415	COG1114	Component of the transport system for branched-chain amino acids
DS740_14420	COG1687	branched-chain amino acid
DS740_14425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DS740_14430	COG1522	sequence-specific DNA binding
DS740_14435	COG2732	(Barnase) inhibitor
DS740_14440	COG2124	cytochrome p450
DS740_14450	COG1335	isochorismatase
DS740_14465	COG2318	DinB family
DS740_14475	COG2070	2-Nitropropane dioxygenase
DS740_14490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DS740_14500	COG2186	Transcriptional regulator
DS740_14515	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_14520	COG3958	Transketolase
DS740_14525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DS740_14530	COG0477	Major facilitator Superfamily
DS740_14535	COG1846	Transcriptional regulator
DS740_14540	COG3443	Belongs to the bacterial solute-binding protein 9 family
DS740_14545	COG1595	DNA-templated transcription, initiation
DS740_14550	COG0667	Aldo Keto reductase
DS740_14555	COG2851	Citrate transporter
DS740_14560	COG0583	DNA-binding transcription factor activity
DS740_14565	COG2828	Protein conserved in bacteria
DS740_14570	COG3409	Peptidoglycan-binding domain 1 protein
DS740_14575	COG5566	PFAM Mor transcription activator
DS740_14580	COG0596	Alpha beta hydrolase
DS740_14585	COG4991	sh3 domain protein
DS740_14590	COG4991	sh3 domain protein
DS740_14595	COG0346	lactoylglutathione lyase activity
DS740_14605	COG5577	PFAM Coat F domain
DS740_14610	COG1063	alcohol dehydrogenase
DS740_14620	COG5577	PFAM Coat F domain
DS740_14625	COG0789	Transcriptional regulator
DS740_14635	COG1064	alcohol dehydrogenase
DS740_14640	COG0693	protein deglycase activity
DS740_14645	COG1621	beta-fructofuranosidase activity
DS740_14650	COG3716	PTS system mannose fructose sorbose family IID component
DS740_14655	COG3715	PTS system
DS740_14660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_14665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_14670	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DS740_14670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DS740_14675	COG1113	amino acid transport
DS740_14680	COG1280	lysine exporter protein (LysE YggA)
DS740_14685	COG1378	Sugar-specific transcriptional regulator TrmB
DS740_14690	COG1595	DNA-templated transcription, initiation
DS740_14700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DS740_14700	COG2755	lipolytic protein G-D-S-L family
DS740_14710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS740_14710	COG2124	cytochrome p450
DS740_14715	COG1309	transcriptional regulator
DS740_14720	COG2226	methyltransferase
DS740_14730	COG2116	formate transmembrane transporter activity
DS740_14735	COG5609	conserved protein (DUF2294)
DS740_14740	COG3383	formate dehydrogenase (NAD+) activity
DS740_14745	COG2427	Protein of unknown function (DUF1641)
DS740_14755	COG0626	cystathionine gamma-synthase activity
DS740_14760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS740_14765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DS740_14770	COG2226	methyltransferase
DS740_14785	COG0768	penicillin binding
DS740_14790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DS740_14795	COG0572	uridine kinase
DS740_14815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DS740_14820	COG3906	Belongs to the UPF0473 family
DS740_14825	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DS740_14830	COG4472	Bacterial protein of unknown function (DUF965)
DS740_14835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DS740_14840	COG0628	permease
DS740_14845	COG1126	abc transporter atp-binding protein
DS740_14850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS740_14855	COG0765	amino acid transport
DS740_14860	COG0765	amino acid transport
DS740_14875	COG3881	PFAM PRC-barrel domain
DS740_14880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DS740_14885	COG0457	Tetratricopeptide repeat
DS740_14890	COG0482	sulfurtransferase activity
DS740_14895	COG1104	cysteine desulfurase activity
DS740_14900	COG1959	2 iron, 2 sulfur cluster binding
DS740_14905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DS740_14910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DS740_14920	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DS740_14925	COG0124	histidyl-tRNA synthetase
DS740_14935	COG3103	Sh3 type 3 domain protein
DS740_14935	COG0860	N-Acetylmuramoyl-L-alanine amidase
DS740_14935	COG4991	sh3 domain protein
DS740_14940	COG1490	D-aminoacyl-tRNA deacylase activity
DS740_14945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DS740_14950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DS740_14955	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DS740_14955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DS740_14960	COG5416	Lipopolysaccharide assembly protein A domain
DS740_14965	COG0490	domain, Protein
DS740_14970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS740_14970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DS740_14980	COG2244	polysaccharide biosynthetic process
DS740_14985	COG2323	membrane
DS740_14995	COG1862	Preprotein translocase
DS740_15000	COG0343	queuine tRNA-ribosyltransferase activity
DS740_15005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DS740_15015	COG2255	four-way junction helicase activity
DS740_15020	COG0632	four-way junction helicase activity
DS740_15030	COG2814	Major facilitator Superfamily
DS740_15035	COG0673	inositol 2-dehydrogenase activity
DS740_15040	COG2112	serine threonine protein kinase
DS740_15055	COG1115	amino acid carrier protein
DS740_15060	COG0217	transcriptional regulatory protein
DS740_15070	COG1388	LysM domain
DS740_15075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DS740_15080	COG0157	Belongs to the NadC ModD family
DS740_15085	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DS740_15090	COG1104	cysteine desulfurase activity
DS740_15095	COG1827	regulation of RNA biosynthetic process
DS740_15100	COG0077	Prephenate dehydratase
DS740_15105	COG4492	Belongs to the UPF0735 family
DS740_15110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DS740_15115	COG3290	protein histidine kinase activity
DS740_15120	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DS740_15125	COG2868	ribosomal protein
DS740_15130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DS740_15135	COG1994	Peptidase M50
DS740_15140	COG0739	heme binding
DS740_15145	COG2894	cell division
DS740_15150	COG0850	regulation of cytokinetic process
DS740_15155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DS740_15160	COG1792	Involved in formation and maintenance of cell shape
DS740_15165	COG1077	Cell shape determining protein MreB Mrl
DS740_15170	COG2003	Belongs to the UPF0758 family
DS740_15175	COG0424	maF-like protein
DS740_15185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DS740_15190	COG0285	dihydrofolate synthase activity
DS740_15195	COG0525	valine-tRNA ligase activity
DS740_15205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS740_15210	COG1388	LysM domain
DS740_15215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DS740_15220	COG0113	porphobilinogen synthase activity
DS740_15225	COG1587	Uroporphyrinogen-III synthase
DS740_15230	COG0181	hydroxymethylbilane synthase activity
DS740_15235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DS740_15240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DS740_15250	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DS740_15255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DS740_15260	COG0470	DNA polymerase III
DS740_15260	COG1067	ATP-dependent peptidase activity
DS740_15265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DS740_15270	COG0544	peptidyl-prolyl cis-trans isomerase activity
DS740_15275	COG1477	protein flavinylation
DS740_15275	COG0457	Tetratricopeptide repeat
DS740_15280	COG0066	3-isopropylmalate dehydratase activity
DS740_15285	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DS740_15290	COG0473	3-isopropylmalate dehydrogenase activity
DS740_15295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DS740_15300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DS740_15305	COG0440	acetolactate synthase activity
DS740_15310	COG0028	Belongs to the TPP enzyme family
DS740_15320	COG0454	-acetyltransferase
DS740_15325	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
DS740_15335	COG0622	Phosphoesterase
DS740_15340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DS740_15345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DS740_15350	COG5401	PFAM Sporulation and spore germination
DS740_15355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DS740_15360	COG1846	Transcriptional regulator
DS740_15365	COG2197	response regulator
DS740_15370	COG0824	Thioesterase
DS740_15375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DS740_15380	COG1053	succinate dehydrogenase
DS740_15385	COG2009	succinate dehydrogenase
DS740_15390	COG1719	4-vinyl reductase, 4VR
DS740_15395	COG0527	aspartate kinase activity
DS740_15405	COG0322	excinuclease ABC activity
DS740_15410	COG3118	belongs to the thioredoxin family
DS740_15420	COG3534	alpha-L-arabinofuranosidase
DS740_15425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DS740_15430	COG2086	electron transfer activity
DS740_15435	COG1024	Enoyl-CoA hydratase
DS740_15440	COG1309	transcriptional regulator
DS740_15445	COG0318	PFAM AMP-dependent synthetase and ligase
DS740_15450	COG3766	membrane
DS740_15455	COG1193	negative regulation of DNA recombination
DS740_15460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DS740_15460	COG1796	DNA polymerase
DS740_15465	COG1286	toxin biosynthetic process
DS740_15470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DS740_15475	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DS740_15480	COG0072	phenylalanine-tRNA ligase activity
DS740_15480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS740_15485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DS740_15495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DS740_15505	COG3835	regulator
DS740_15510	COG0277	FAD linked oxidase domain protein
DS740_15515	COG0247	lactate metabolic process
DS740_15520	COG0346	lactoylglutathione lyase activity
DS740_15530	COG1966	Carbon starvation protein
DS740_15535	COG3534	alpha-L-arabinofuranosidase
DS740_15540	COG0395	ABC-type sugar transport system, permease component
DS740_15545	COG1175	transmembrane transport
DS740_15550	COG1653	transport
DS740_15555	COG0371	Dehydrogenase
DS740_15560	COG0647	UMP catabolic process
DS740_15565	COG0235	Class ii aldolase
DS740_15570	COG1069	ribulokinase activity
DS740_15575	COG2160	L-arabinose isomerase activity
DS740_15580	COG3507	Belongs to the glycosyl hydrolase 43 family
DS740_15585	COG1363	Peptidase, m42
DS740_15595	COG3326	Membrane
DS740_15600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DS740_15605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DS740_15610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DS740_15620	COG1346	cytolysis
DS740_15625	COG1380	Effector of murein hydrolase LrgA
DS740_15630	COG3279	Response regulator of the LytR AlgR family
DS740_15635	COG3275	phosphorelay sensor kinase activity
DS740_15645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DS740_15655	COG0398	Pfam SNARE associated Golgi protein
DS740_15660	COG1484	DNA-dependent DNA replication
DS740_15665	COG3611	Membrane attachment protein
DS740_15670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DS740_15675	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DS740_15680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DS740_15685	COG1733	regulation of RNA biosynthetic process
DS740_15690	COG2814	Major facilitator Superfamily
DS740_15695	COG0656	L-ascorbic acid biosynthetic process
DS740_15700	COG0237	dephospho-CoA kinase activity
DS740_15705	COG1971	Probably functions as a manganese efflux pump
DS740_15710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DS740_15715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS740_15715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DS740_15720	COG5002	protein histidine kinase activity
DS740_15725	COG0745	RESPONSE REGULATOR receiver
DS740_15730	COG0039	L-malate dehydrogenase activity
DS740_15735	COG0538	isocitrate dehydrogenase activity
DS740_15740	COG0372	Belongs to the citrate synthase family
DS740_15745	COG2707	UPF0756 membrane protein
DS740_15750	COG0628	permease
DS740_15755	COG3030	protein affecting phage T7 exclusion by the F plasmid
DS740_15760	COG0469	pyruvate kinase activity
DS740_15765	COG0205	6-phosphofructokinase activity
DS740_15770	COG0825	malonyl-CoA metabolic process
DS740_15775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DS740_15780	COG0281	malic enzyme
DS740_15805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DS740_15815	COG4109	DRTGG domain
DS740_15820	COG0730	response to heat
DS740_15825	COG1473	amidohydrolase
DS740_15830	COG0196	riboflavin kinase activity
DS740_15835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS740_15840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DS740_15845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS740_15850	COG1126	abc transporter atp-binding protein
DS740_15855	COG0765	amino acid transport
DS740_15860	COG0765	amino acid transport
DS740_15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS740_15870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS740_15875	COG0454	-acetyltransferase
DS740_15880	COG0583	DNA-binding transcription factor activity
DS740_15885	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DS740_15890	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_15900	COG0165	Argininosuccinate lyase
DS740_15905	COG0137	argininosuccinate synthase activity
DS740_15910	COG0521	Mo-molybdopterin cofactor biosynthetic process
DS740_15915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DS740_15925	COG0827	DNA restriction-modification system
DS740_15930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DS740_15935	COG3874	Sporulation protein YtfJ
DS740_15945	COG1714	RDD family
DS740_15950	COG0616	signal peptide processing
DS740_15955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DS740_15960	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DS740_15965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DS740_15975	COG0301	tRNA thio-modification
DS740_15980	COG1104	cysteine desulfurase activity
DS740_15985	COG1114	Component of the transport system for branched-chain amino acids
DS740_15990	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DS740_15995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DS740_16000	COG1309	transcriptional regulator
DS740_16005	COG1956	GAF domain-containing protein
DS740_16010	COG2203	Gaf domain
DS740_16010	COG2199	diguanylate cyclase activity
DS740_16020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DS740_16025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DS740_16035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DS740_16040	COG0454	-acetyltransferase
DS740_16045	COG0517	IMP dehydrogenase activity
DS740_16050	COG0123	including yeast histone deacetylase and acetoin utilization protein
DS740_16055	COG1360	Flagellar Motor Protein
DS740_16060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DS740_16065	COG1609	Transcriptional regulator
DS740_16070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DS740_16070	COG1605	Chorismate mutase
DS740_16075	COG3118	belongs to the thioredoxin family
DS740_16080	COG4980	gas vesicle protein
DS740_16085	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DS740_16090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DS740_16095	COG1674	ftsk spoiiie
DS740_16100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DS740_16105	COG4848	Belongs to the UPF0354 family
DS740_16110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_16120	COG1363	Peptidase, m42
DS740_16125	COG5584	Small secreted protein
DS740_16130	COG0281	malic enzyme
DS740_16135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_16140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DS740_16150	COG0510	thiamine kinase activity
DS740_16155	COG1523	belongs to the glycosyl hydrolase 13 family
DS740_16160	COG1597	lipid kinase activity
DS740_16170	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DS740_16175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DS740_16180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DS740_16185	COG2252	PERMEase
DS740_16190	COG4473	ABC transporter
DS740_16195	COG1131	(ABC) transporter
DS740_16200	COG1349	DNA-binding transcription factor activity
DS740_16205	COG1187	pseudouridine synthase activity
DS740_16210	COG2244	polysaccharide biosynthetic process
DS740_16215	COG2081	HI0933 family
DS740_16220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DS740_16230	COG5578	integral membrane protein
DS740_16235	COG0673	inositol 2-dehydrogenase activity
DS740_16240	COG1653	transport
DS740_16245	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DS740_16250	COG4209	transmembrane transport
DS740_16255	COG2207	Transcriptional regulator
DS740_16260	COG1653	transport
DS740_16265	COG0395	ABC-type sugar transport system, permease component
DS740_16270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS740_16275	COG2124	cytochrome p450
DS740_16280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DS740_16290	COG0156	8-amino-7-oxononanoate synthase activity
DS740_16295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DS740_16305	COG1073	alpha beta
DS740_16330	COG1486	melibiose metabolic process
DS740_16335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DS740_16340	COG0495	leucyl-tRNA aminoacylation
DS740_16350	COG1366	Belongs to the anti-sigma-factor antagonist family
DS740_16350	COG2202	Pas domain
DS740_16355	COG2814	Major facilitator Superfamily
DS740_16360	COG2433	Pfam Transposase IS66
DS740_16365	COG0577	efflux transmembrane transporter activity
DS740_16370	COG1136	(ABC) transporter
DS740_16375	COG2205	protein histidine kinase activity
DS740_16380	COG0745	RESPONSE REGULATOR receiver
DS740_16385	COG0577	efflux transmembrane transporter activity
DS740_16390	COG1136	(ABC) transporter
DS740_16405	COG1131	(ABC) transporter
DS740_16410	COG1725	Transcriptional regulator
DS740_16420	COG1242	4 iron, 4 sulfur cluster binding
DS740_16425	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DS740_16435	COG2267	carboxylic ester hydrolase activity
DS740_16440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DS740_16445	COG1113	amino acid transport
DS740_16450	COG0367	asparagine synthase
DS740_16455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DS740_16460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DS740_16470	COG1506	peptidase
DS740_16475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DS740_16480	COG1116	anion transmembrane transporter activity
DS740_16485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DS740_16490	COG0494	nUDIX hydrolase
DS740_16495	COG4824	toxin secretion phage lysis holin
DS740_16500	COG0783	Belongs to the Dps family
DS740_16515	COG1854	S-ribosylhomocysteine lyase activity
DS740_16520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DS740_16525	COG0288	reversible hydration of carbon dioxide
DS740_16530	COG0254	rRNA binding
DS740_16535	COG1271	oxidase subunit
DS740_16540	COG1294	oxidase, subunit
DS740_16550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DS740_16555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DS740_16555	COG1321	iron dependent repressor
DS740_16560	COG1121	(ABC) transporter
DS740_16565	COG0803	Belongs to the bacterial solute-binding protein 9 family
DS740_16570	COG4948	Mandelate Racemase Muconate Lactonizing
DS740_16575	COG0318	PFAM AMP-dependent synthetase and ligase
DS740_16580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DS740_16585	COG0596	Alpha beta hydrolase
DS740_16590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DS740_16595	COG1169	isochorismate synthase
DS740_16605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DS740_16610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DS740_16615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DS740_16620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DS740_16625	COG0438	transferase activity, transferring glycosyl groups
DS740_16635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS740_16640	COG0438	transferase activity, transferring glycosyl groups
DS740_16645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS740_16650	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DS740_16655	COG0058	SHG alpha-glucan phosphorylase activity
DS740_16660	COG0297	glycogen (starch) synthase activity
DS740_16665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DS740_16670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DS740_16675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DS740_16800	COG3859	Proton-coupled thiamine transporter YuaJ
DS740_16805	COG1247	-acetyltransferase
DS740_16810	COG2268	Band 7 protein
DS740_16815	COG1585	Membrane protein implicated in regulation of membrane protease activity
DS740_16820	COG2318	DinB family
DS740_16830	COG1454	alcohol dehydrogenase
DS740_16840	COG1510	regulation of RNA biosynthetic process
DS740_16850	COG0569	domain protein
DS740_16855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DS740_16860	COG4682	membrane
DS740_16865	COG1705	Flagellar rod assembly protein muramidase FlgJ
DS740_16870	COG0477	Major facilitator Superfamily
DS740_16875	COG5553	Cysteine dioxygenase type I
DS740_16885	COG1968	undecaprenyl-diphosphatase activity
DS740_16890	COG0628	permease
DS740_16895	COG0673	inositol 2-dehydrogenase activity
DS740_16900	COG4806	L-rhamnose isomerase
DS740_16905	COG3254	rhamnose metabolic process
DS740_16910	COG1070	Carbohydrate kinase
DS740_16915	COG1349	DNA-binding transcription factor activity
DS740_16920	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_16920	COG3347	Dehydrogenase
DS740_16930	COG0840	transmembrane signaling receptor activity
DS740_16935	COG0840	transmembrane signaling receptor activity
DS740_16940	COG0840	transmembrane signaling receptor activity
DS740_16945	COG0840	transmembrane signaling receptor activity
DS740_16960	COG0432	Pfam Uncharacterised protein family UPF0047
DS740_16965	COG0366	Alpha amylase catalytic
DS740_16970	COG1253	flavin adenine dinucleotide binding
DS740_16975	COG2738	Putative neutral zinc metallopeptidase
DS740_16990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DS740_17005	COG0166	Belongs to the GPI family
DS740_17010	COG1979	alcohol dehydrogenase
DS740_17015	COG1979	alcohol dehydrogenase
DS740_17020	COG2155	Conserved Protein
DS740_17025	COG1098	S1 RNA binding domain
DS740_17030	COG0436	Aminotransferase
DS740_17035	COG1522	sequence-specific DNA binding
DS740_17040	COG2267	carboxylic ester hydrolase activity
DS740_17050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DS740_17055	COG2205	protein histidine kinase activity
DS740_17065	COG5018	Exonuclease
DS740_17075	COG2814	Major facilitator Superfamily
DS740_17080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DS740_17085	COG3011	Protein conserved in bacteria
DS740_17095	COG3290	protein histidine kinase activity
DS740_17100	COG4565	transcriptional regulatory protein
DS740_17125	COG3493	citrate carrier protein
DS740_17135	COG2111	Na H antiporter
DS740_17135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DS740_17140	COG2111	Na H antiporter
DS740_17145	COG1006	Multisubunit Na H antiporter MnhC subunit
DS740_17150	COG0651	ATP synthesis coupled electron transport
DS740_17155	COG1863	multisubunit Na H antiporter MnhE subunit
DS740_17160	COG2212	antiporter activity
DS740_17165	COG1320	monovalent cation:proton antiporter activity
DS740_17170	COG2050	protein possibly involved in aromatic compounds catabolism
DS740_17175	COG2197	response regulator
DS740_17180	COG4585	Histidine kinase
DS740_17190	COG0142	geranyltranstransferase activity
DS740_17205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DS740_17210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DS740_17215	COG1335	isochorismatase
DS740_17220	COG5506	Protein of unknown function (DUF1694)
DS740_17235	COG0628	permease
DS740_17250	COG1418	mRNA catabolic process
DS740_17255	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_17265	COG1511	domain protein
DS740_17270	COG0433	COG0433 Predicted ATPase
DS740_17270	COG1674	ftsk spoiiie
DS740_17275	COG4499	WXG100 protein secretion system (Wss), protein YukC
DS740_17280	COG5417	Belongs to the EsaB family
DS740_17285	COG4842	Belongs to the WXG100 family
DS740_17290	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DS740_17290	COG2508	Transcriptional regulator
DS740_17295	COG0686	Belongs to the AlaDH PNT family
DS740_17300	COG5634	Uncharacterized conserved protein (DUF2278)
DS740_17305	COG3251	PFAM MbtH domain protein
DS740_17310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_17315	COG1535	isochorismatase
DS740_17315	COG3433	isochorismatase activity
DS740_17320	COG1021	2,3-dihydroxybenzoate-AMP ligase
DS740_17325	COG1169	isochorismate synthase
DS740_17330	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_17335	COG2819	hydrolase of the alpha beta superfamily
DS740_17340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DS740_17345	COG1268	BioY protein
DS740_17350	COG2056	Na+-H+ antiporter family
DS740_17355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DS740_17360	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DS740_17365	COG3584	3D domain protein
DS740_17380	COG1252	NADH dehydrogenase
DS740_17385	COG0492	ferredoxin-NADP+ reductase activity
DS740_17395	COG0516	GMP reductase activity
DS740_17400	COG2808	Putative FMN-binding domain
DS740_17405	COG0456	acetyltransferase
DS740_17410	COG0316	Belongs to the HesB IscA family
DS740_17415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DS740_17420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DS740_17425	COG4844	belongs to the
DS740_17430	COG1252	NADH dehydrogenase
DS740_17435	COG4837	Protein of unknown function (DUF1462)
DS740_17440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DS740_17445	COG4946	Tricorn protease homolog
DS740_17445	COG1506	peptidase
DS740_17445	COG0823	Involved in the tonB-independent uptake of proteins
DS740_17450	COG0083	homoserine kinase activity
DS740_17455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DS740_17460	COG0460	homoserine dehydrogenase
DS740_17465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DS740_17470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DS740_17475	COG0647	UMP catabolic process
DS740_17480	COG2445	Protein of unknown function DUF86
DS740_17485	COG4470	Protein conserved in bacteria
DS740_17495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DS740_17500	COG0739	heme binding
DS740_17510	COG3377	Domain of unknown function (DUF1805)
DS740_17515	COG0737	Belongs to the 5'-nucleotidase family
DS740_17520	COG0730	response to heat
DS740_17525	COG1801	Protein of unknown function DUF72
DS740_17535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DS740_17540	COG2508	Transcriptional regulator
DS740_17545	COG2233	PERMEase
DS740_17550	COG2233	PERMEase
DS740_17555	COG3195	allantoin biosynthetic process
DS740_17555	COG3648	Uricase
DS740_17560	COG2351	hydroxyisourate hydrolase activity
DS740_17570	COG2080	2 iron, 2 sulfur cluster binding
DS740_17575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DS740_17580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DS740_17585	COG2068	MobA-Related Protein
DS740_17590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DS740_17595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DS740_17600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DS740_17605	COG2356	endonuclease I
DS740_17610	COG3842	ATPase activity
DS740_17615	COG2188	Transcriptional regulator
DS740_17620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS740_17625	COG0395	ABC-type sugar transport system, permease component
DS740_17630	COG1175	transmembrane transport
DS740_17635	COG1653	transport
DS740_17640	COG2222	sugar isomerase
DS740_17645	COG0322	excinuclease ABC activity
DS740_17650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DS740_17665	COG0346	lactoylglutathione lyase activity
DS740_17670	COG0640	Transcriptional regulator
DS740_17675	COG0719	Fe-S assembly protein
DS740_17680	COG0822	iron-sulfur transferase activity
DS740_17685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DS740_17690	COG0719	Fe-S assembly protein
DS740_17695	COG0396	ATPase activity
DS740_17710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DS740_17715	COG1464	Belongs to the NlpA lipoprotein family
DS740_17720	COG2011	ABC-type metal ion transport system permease component
DS740_17725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DS740_17735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DS740_17740	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DS740_17750	COG0509	glycine decarboxylation via glycine cleavage system
DS740_17755	COG1393	Belongs to the ArsC family
DS740_17760	COG1960	acyl-CoA dehydrogenase activity
DS740_17765	COG0183	Belongs to the thiolase family
DS740_17770	COG1250	3-hydroxyacyl-CoA dehydrogenase
DS740_17770	COG1024	Enoyl-CoA hydratase
DS740_17780	COG0506	proline dehydrogenase activity
DS740_17790	COG5577	PFAM Coat F domain
DS740_17795	COG1846	Transcriptional regulator
DS740_17800	COG0477	Major facilitator Superfamily
DS740_17805	COG1942	4-Oxalocrotonate Tautomerase
DS740_17815	COG0583	DNA-binding transcription factor activity
DS740_17825	COG1120	ATPase activity
DS740_17840	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_17845	COG0783	Belongs to the Dps family
DS740_17850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS740_17855	COG0745	RESPONSE REGULATOR receiver
DS740_17860	COG2205	protein histidine kinase activity
DS740_17860	COG2770	Histidine kinase
DS740_17870	COG1309	transcriptional regulator
DS740_17875	COG0114	fumarate hydratase activity
DS740_17885	COG0697	spore germination
DS740_17890	COG0814	amino acid
DS740_17900	COG2197	response regulator
DS740_17905	COG4585	Histidine kinase
DS740_17910	COG4758	membrane
DS740_17915	COG3595	metallopeptidase activity
DS740_17920	COG1842	Phage shock protein A
DS740_17925	COG4758	membrane
DS740_17930	COG2814	Major facilitator Superfamily
DS740_17935	COG2096	Adenosyltransferase
DS740_17940	COG1120	ATPase activity
DS740_17945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_17950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS740_17955	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_17960	COG3386	PFAM SMP-30 Gluconolaconase
DS740_17965	COG2205	protein histidine kinase activity
DS740_17970	COG0745	RESPONSE REGULATOR receiver
DS740_17980	COG1191	sigma factor activity
DS740_17990	COG2140	Oxalate decarboxylase
DS740_18000	COG0577	efflux transmembrane transporter activity
DS740_18005	COG1136	(ABC) transporter
DS740_18010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DS740_18015	COG1120	ATPase activity
DS740_18020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_18025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DS740_18030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS740_18040	COG0531	amino acid
DS740_18055	COG1988	membrane-bound metal-dependent
DS740_18060	COG1368	sulfuric ester hydrolase activity
DS740_18065	COG1910	domain protein
DS740_18070	COG0725	ABC transporter, periplasmic molybdate-binding protein
DS740_18075	COG4149	molybdate abc transporter
DS740_18080	COG0656	L-ascorbic acid biosynthetic process
DS740_18090	COG0025	NhaP-type Na H and K H
DS740_18095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DS740_18100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DS740_18105	COG3973	AAA domain
DS740_18115	COG2860	membrane
DS740_18120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DS740_18125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DS740_18130	COG2217	Heavy metal translocating P-type atpase
DS740_18135	COG2217	Heavy metal translocating P-type atpase
DS740_18140	COG2608	mercury ion transmembrane transporter activity
DS740_18145	COG1937	Protein conserved in bacteria
DS740_18150	COG0673	inositol 2-dehydrogenase activity
DS740_18155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DS740_18160	COG1289	transmembrane transporter activity
DS740_18170	COG2076	Multidrug Resistance protein
DS740_18175	COG1309	transcriptional regulator
DS740_18180	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_18205	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DS740_18210	COG0557	exoribonuclease II activity
DS740_18215	COG1647	Serine aminopeptidase, S33
DS740_18220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DS740_18225	COG0596	Alpha beta hydrolase
DS740_18230	COG1476	TRANSCRIPTIONal
DS740_18235	COG1396	sequence-specific DNA binding
DS740_18240	COG1396	sequence-specific DNA binding
DS740_18245	COG1733	regulation of RNA biosynthetic process
DS740_18250	COG0840	transmembrane signaling receptor activity
DS740_18305	COG1174	glycine betaine transport
DS740_18310	COG1732	Glycine betaine
DS740_18315	COG1174	glycine betaine transport
DS740_18320	COG1125	glycine betaine transport
DS740_18320	COG0517	IMP dehydrogenase activity
DS740_18325	COG1510	regulation of RNA biosynthetic process
DS740_18330	COG1174	glycine betaine transport
DS740_18335	COG1732	Glycine betaine
DS740_18340	COG1174	glycine betaine transport
DS740_18345	COG0517	IMP dehydrogenase activity
DS740_18345	COG1125	glycine betaine transport
DS740_18350	COG1510	regulation of RNA biosynthetic process
DS740_18355	COG2095	MarC family integral membrane protein
DS740_18365	COG3064	Membrane
DS740_18370	COG4640	response to antibiotic
DS740_18375	COG0456	acetyltransferase
DS740_18380	COG0148	phosphopyruvate hydratase activity
DS740_18385	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DS740_18390	COG0149	triose-phosphate isomerase activity
DS740_18395	COG0126	phosphoglycerate kinase activity
DS740_18400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DS740_18405	COG2390	Transcriptional regulator
DS740_18410	COG2814	Major facilitator Superfamily
DS740_18415	COG1609	Transcriptional regulator
DS740_18420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS740_18430	COG0583	DNA-binding transcription factor activity
DS740_18435	COG0697	spore germination
DS740_18440	COG1113	amino acid transport
DS740_18445	COG3858	chitin binding
DS740_18450	COG1556	Lactate utilization protein
DS740_18455	COG1139	Iron-sulfur cluster binding protein
DS740_18460	COG0247	lactate metabolic process
DS740_18465	COG2197	response regulator
DS740_18470	COG4585	Histidine kinase
DS740_18475	COG0842	Transport permease protein
DS740_18480	COG1131	(ABC) transporter
DS740_18485	COG0596	Alpha beta hydrolase
DS740_18490	COG2208	phosphoserine phosphatase activity
DS740_18495	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DS740_18500	COG1874	Beta-galactosidase
DS740_18505	COG3833	ABC-type maltose transport systems, permease component
DS740_18510	COG1175	transmembrane transport
DS740_18515	COG2182	Extracellular solute-binding protein
DS740_18520	COG1609	Transcriptional regulator
DS740_18525	COG2186	Transcriptional regulator
DS740_18530	COG1620	l-lactate permease
DS740_18535	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DS740_18545	COG5039	Polysaccharide pyruvyl transferase
DS740_18550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DS740_18555	COG0110	maltose O-acetyltransferase activity
DS740_18560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DS740_18565	COG2244	polysaccharide biosynthetic process
DS740_18570	COG1216	Glycosyl transferase, family 2
DS740_18575	COG5039	Polysaccharide pyruvyl transferase
DS740_18580	COG1216	Glycosyl transferase, family 2
DS740_18590	COG0438	transferase activity, transferring glycosyl groups
DS740_18595	COG1215	transferase activity, transferring glycosyl groups
DS740_18600	COG0438	transferase activity, transferring glycosyl groups
DS740_18605	COG1086	Polysaccharide biosynthesis protein
DS740_18610	COG0489	protein tyrosine kinase activity
DS740_18615	COG3944	biosynthesis protein
DS740_18620	COG1396	sequence-specific DNA binding
DS740_18625	COG2272	Belongs to the type-B carboxylesterase lipase family
DS740_18635	COG3479	Phenolic acid decarboxylase
DS740_18645	COG1794	racemase activity, acting on amino acids and derivatives
DS740_18650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DS740_18655	COG1621	beta-fructofuranosidase activity
DS740_18660	COG1621	beta-fructofuranosidase activity
DS740_18665	COG0531	amino acid
DS740_18670	COG1309	transcriptional regulator
DS740_18675	COG2076	Multidrug Resistance protein
DS740_18680	COG2076	Multidrug Resistance protein
DS740_18695	COG0740	serine-type endopeptidase activity
DS740_18700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DS740_18705	COG0366	Alpha amylase catalytic
DS740_18710	COG1554	hydrolase, family 65, central catalytic
DS740_18715	COG5521	maltodextrose utilization protein MalA
DS740_18720	COG3833	ABC-type maltose transport systems, permease component
DS740_18725	COG1175	transmembrane transport
DS740_18730	COG2182	Extracellular solute-binding protein
DS740_18740	COG1609	Transcriptional regulator
DS740_18745	COG1611	Belongs to the LOG family
DS740_18750	COG1694	Mazg nucleotide pyrophosphohydrolase
DS740_18755	COG0659	secondary active sulfate transmembrane transporter activity
DS740_18760	COG0288	reversible hydration of carbon dioxide
DS740_18765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DS740_18770	COG0577	efflux transmembrane transporter activity
DS740_18775	COG1136	(ABC) transporter
DS740_18780	COG5002	protein histidine kinase activity
DS740_18785	COG0745	RESPONSE REGULATOR receiver
DS740_18800	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DS740_18805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_18810	COG1481	regulation of sporulation
DS740_18815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DS740_18820	COG1660	Displays ATPase and GTPase activities
DS740_18825	COG1051	belongs to the nudix hydrolase family
DS740_18830	COG0492	ferredoxin-NADP+ reductase activity
DS740_18835	COG3883	PFAM NLP P60 protein
DS740_18835	COG0791	NLP P60 protein
DS740_18840	COG0457	Tetratricopeptide repeat
DS740_18845	COG1132	(ABC) transporter
DS740_18865	COG0140	phosphoribosyl-ATP diphosphatase activity
DS740_18865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DS740_18870	COG0107	imidazoleglycerol-phosphate synthase activity
DS740_18875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DS740_18880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DS740_18885	COG0131	Imidazoleglycerol-phosphate dehydratase
DS740_18890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DS740_18895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DS740_18900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DS740_18905	COG4990	cell redox homeostasis
DS740_18910	COG5297	Belongs to the glycosyl hydrolase family 6
DS740_18915	COG0110	maltose O-acetyltransferase activity
DS740_18920	COG0546	phosphoglycolate phosphatase activity
DS740_18925	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DS740_18930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DS740_18935	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DS740_18940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DS740_18945	COG0363	glucosamine-6-phosphate deaminase activity
DS740_18955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DS740_18960	COG1846	Transcriptional regulator
DS740_18975	COG1846	Transcriptional regulator
DS740_18980	COG2814	Major facilitator Superfamily
DS740_18985	COG1950	PFAM Membrane protein of
DS740_18990	COG1983	PspC domain protein
DS740_18995	COG3595	metallopeptidase activity
DS740_19015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DS740_19020	COG0556	nucleotide-excision repair
DS740_19025	COG4897	Protein conserved in bacteria
DS740_19030	COG3848	Pyruvate phosphate dikinase
DS740_19030	COG0574	Belongs to the PEP-utilizing enzyme family
DS740_19035	COG1309	transcriptional regulator
DS740_19040	COG2814	Major facilitator Superfamily
DS740_19045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS740_19055	COG3409	Peptidoglycan-binding domain 1 protein
DS740_19055	COG0793	Belongs to the peptidase S41A family
DS740_19060	COG2177	Part of the ABC transporter FtsEX involved in
DS740_19065	COG2884	Cell division ATP-binding protein ftsE
DS740_19070	COG2010	Cytochrome c
DS740_19075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DS740_19085	COG0653	protein targeting
DS740_19090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DS740_19105	COG1516	flagellar protein fliS
DS740_19110	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DS740_19115	COG1334	flagellar protein FlaG
DS740_19120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DS740_19125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DS740_19130	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DS740_19140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DS740_19145	COG1256	bacterial-type flagellum assembly
DS740_19145	COG4786	Flagellar basal body rod
DS740_19150	COG3418	PFAM FlgN family protein
DS740_19155	COG2747	anti-sigma28 factor FlgM
DS740_19165	COG1040	competence protein
DS740_19175	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DS740_19180	COG1307	EDD domain protein, DegV family
DS740_19185	COG2197	response regulator
DS740_19190	COG4585	Histidine kinase
DS740_19195	COG1739	Uncharacterized protein family UPF0029
DS740_19200	COG1316	TRANSCRIPTIONal
DS740_19205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DS740_19210	COG0438	transferase activity, transferring glycosyl groups
DS740_19215	COG1215	transferase activity, transferring glycosyl groups
DS740_19220	COG3206	protein involved in exopolysaccharide biosynthesis
DS740_19225	COG3307	-O-antigen
DS740_19230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DS740_19235	COG0297	glycogen (starch) synthase activity
DS740_19235	COG0438	transferase activity, transferring glycosyl groups
DS740_19240	COG2244	polysaccharide biosynthetic process
DS740_19255	COG2247	cell wall binding repeat
DS740_19255	COG0860	N-Acetylmuramoyl-L-alanine amidase
DS740_19260	COG2247	cell wall binding repeat
DS740_19260	COG2385	sporulation resulting in formation of a cellular spore
DS740_19270	COG1316	TRANSCRIPTIONal
DS740_19275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DS740_19295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DS740_19300	COG1134	teichoic acid transport
DS740_19305	COG1682	transport, permease protein
DS740_19310	COG1215	transferase activity, transferring glycosyl groups
DS740_19310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DS740_19315	COG0463	Glycosyl transferase, family 2
DS740_19360	COG4193	domain, Protein
DS740_19365	COG1482	cell wall glycoprotein biosynthetic process
DS740_19370	COG0697	spore germination
DS740_19375	COG0814	amino acid
DS740_19385	COG2814	Major facilitator Superfamily
DS740_19390	COG1316	TRANSCRIPTIONal
DS740_19395	COG0561	phosphatase activity
DS740_19400	COG0791	NLP P60 protein
DS740_19410	COG2843	Capsule synthesis protein
DS740_19420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DS740_19425	COG1609	Transcriptional regulator
DS740_19430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS740_19435	COG1869	D-ribose catabolic process
DS740_19440	COG1129	ABC transporter
DS740_19445	COG1172	Belongs to the binding-protein-dependent transport system permease family
DS740_19450	COG1879	ABC-type sugar transport system periplasmic component
DS740_19455	COG3103	Sh3 type 3 domain protein
DS740_19465	COG2249	NAD(P)H dehydrogenase (quinone) activity
DS740_19470	COG3527	Alpha-acetolactate decarboxylase
DS740_19475	COG0028	Belongs to the TPP enzyme family
DS740_19480	COG0583	DNA-binding transcription factor activity
DS740_19485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DS740_19500	COG5337	Spore coat protein CotH
DS740_19510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DS740_19520	COG0405	Gamma-glutamyltransferase
DS740_19525	COG1522	sequence-specific DNA binding
DS740_19530	COG2059	Chromate
DS740_19535	COG2059	Chromate
DS740_19550	COG5444	nuclease activity
DS740_19570	COG3878	Protein conserved in bacteria
DS740_19575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DS740_19580	COG4464	protein tyrosine phosphatase activity
DS740_19585	COG0489	protein tyrosine kinase activity
DS740_19590	COG3944	biosynthesis protein
DS740_19600	COG4715	Zinc finger, swim domain protein
DS740_19605	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DS740_19620	COG1349	DNA-binding transcription factor activity
DS740_19625	COG0629	single-stranded DNA binding
DS740_19640	COG3764	Sortase (surface protein transpeptidase)
DS740_19650	COG3279	Response regulator of the LytR AlgR family
DS740_19655	COG0745	RESPONSE REGULATOR receiver
DS740_19655	COG2972	Histidine kinase
DS740_19660	COG1970	mechanosensitive ion channel activity
DS740_19665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DS740_19670	COG0457	Tetratricopeptide repeat
DS740_19675	COG4786	Flagellar basal body rod
DS740_19680	COG4786	Flagellar basal body rod
DS740_19685	COG1077	Cell shape determining protein MreB Mrl
DS740_19690	COG1609	Transcriptional regulator
DS740_19700	COG1846	Transcriptional regulator
DS740_19705	COG2814	Major facilitator Superfamily
DS740_19710	COG3420	alginic acid biosynthetic process
DS740_19715	COG1953	Uracil, thiamine, allantoin
DS740_19720	COG0477	Major facilitator Superfamily
DS740_19725	COG1335	isochorismatase
DS740_19735	COG0004	ammonium transporteR
DS740_19740	COG0347	Belongs to the P(II) protein family
DS740_19745	COG0671	phosphoesterase, PA-phosphatase related
DS740_19755	COG0739	heme binding
DS740_19760	COG1247	-acetyltransferase
DS740_19775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DS740_19780	COG0789	Transcriptional regulator
DS740_19790	COG2910	NAD(P)H-binding
DS740_19795	COG1959	2 iron, 2 sulfur cluster binding
DS740_19800	COG0804	urea catabolic process
DS740_19805	COG0832	Belongs to the urease beta subunit family
DS740_19810	COG0831	urea catabolic process
DS740_19825	COG3237	CsbD-like
DS740_19830	COG1994	Peptidase M50
DS740_19835	COG0457	Tetratricopeptide repeat
DS740_19845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DS740_19850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DS740_19860	COG2304	oxidoreductase activity
DS740_19870	COG2304	oxidoreductase activity
DS740_19875	COG2385	sporulation resulting in formation of a cellular spore
DS740_19880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DS740_19890	COG4836	Membrane
DS740_19900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DS740_19905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DS740_19910	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DS740_19915	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DS740_19920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DS740_19925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DS740_19930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DS740_19935	COG0356	it plays a direct role in the translocation of protons across the membrane
DS740_19945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DS740_19950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DS740_19955	COG4475	Protein of unknown function (DUF436)
DS740_19960	COG0698	ribose 5-phosphate isomerase
DS740_19965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DS740_19970	COG1971	Probably functions as a manganese efflux pump
DS740_19975	COG0009	L-threonylcarbamoyladenylate synthase
DS740_19980	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DS740_20000	COG2890	protein-(glutamine-N5) methyltransferase activity
DS740_20005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DS740_20010	COG0346	lactoylglutathione lyase activity
DS740_20015	COG0789	Transcriptional regulator
DS740_20020	COG0679	Auxin Efflux Carrier
DS740_20025	COG0281	malic enzyme
DS740_20030	COG1435	thymidine kinase activity
DS740_20035	COG0254	rRNA binding
DS740_20040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DS740_20045	COG1494	fructose-1,6-bisphosphatase
DS740_20050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DS740_20055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DS740_20060	COG0191	fructose-bisphosphate aldolase activity
DS740_20065	COG2204	response regulator
DS740_20070	COG4821	SIS domain
DS740_20075	COG0504	CTP synthase activity
DS740_20080	COG3343	RNA polymerase activity
DS740_20085	COG1960	acyl-CoA dehydrogenase activity
DS740_20090	COG2181	nitrate reductase activity
DS740_20090	COG0247	lactate metabolic process
DS740_20095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DS740_20100	COG4294	response to UV
DS740_20110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DS740_20115	COG1132	(ABC) transporter
DS740_20120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DS740_20130	COG2181	nitrate reductase activity
DS740_20135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DS740_20140	COG1140	nitrate reductase beta subunit
DS740_20145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DS740_20150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DS740_20160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DS740_20165	COG2223	nitrite transmembrane transporter activity
DS740_20170	COG0018	arginyl-trna synthetase
DS740_20175	COG4506	Protein conserved in bacteria
DS740_20190	COG0535	radical SAM domain protein
DS740_20200	COG1131	(ABC) transporter
DS740_20205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DS740_20210	COG0612	Peptidase, M16
DS740_20215	COG0612	Peptidase, M16
DS740_20225	COG3391	amine dehydrogenase activity
DS740_20230	COG3391	amine dehydrogenase activity
DS740_20240	COG0457	Tetratricopeptide repeat
DS740_20270	COG1131	(ABC) transporter
DS740_20280	COG0010	Belongs to the arginase family
DS740_20285	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DS740_20290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DS740_20305	COG1994	Peptidase M50
DS740_20310	COG1942	4-Oxalocrotonate Tautomerase
DS740_20315	COG1846	Transcriptional regulator
DS740_20320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DS740_20325	COG0477	Major facilitator Superfamily
DS740_20330	COG1959	2 iron, 2 sulfur cluster binding
DS740_20335	COG3465	dGTPase activity
DS740_20340	COG1078	dGTPase activity
DS740_20345	COG4844	belongs to the
DS740_20355	COG0697	spore germination
DS740_20360	COG0095	Lipoate-protein ligase
DS740_20365	COG0583	DNA-binding transcription factor activity
DS740_20370	COG0280	phosphate acetyltransferase
DS740_20380	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_20385	COG0436	Aminotransferase
DS740_20390	COG2814	Major facilitator Superfamily
DS740_20395	COG0151	Belongs to the GarS family
DS740_20400	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_20405	COG1917	Cupin 2, conserved barrel domain protein
DS740_20410	COG0077	Prephenate dehydratase
DS740_20415	COG2814	Major facilitator Superfamily
DS740_20420	COG0833	amino acid
DS740_20425	COG4187	Peptidase family M20/M25/M40
DS740_20430	COG1012	belongs to the aldehyde dehydrogenase family
DS740_20435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DS740_20445	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DS740_20450	COG1091	dTDP-4-dehydrorhamnose reductase activity
DS740_20455	COG1088	dTDP-glucose 4,6-dehydratase activity
DS740_20460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DS740_20465	COG3980	spore coat polysaccharide biosynthesis protein
DS740_20470	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DS740_20475	COG2089	acid synthase
DS740_20480	COG0456	acetyltransferase
DS740_20485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DS740_20490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DS740_20495	COG0463	Glycosyl transferase, family 2
DS740_20510	COG2363	Small membrane protein
DS740_20515	COG2233	PERMEase
DS740_20525	COG1012	belongs to the aldehyde dehydrogenase family
DS740_20530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DS740_20535	COG1216	Glycosyl transferase, family 2
DS740_20550	COG1695	Transcriptional regulator
DS740_20555	COG0351	phosphomethylpyrimidine kinase
DS740_20565	COG1621	beta-fructofuranosidase activity
DS740_20570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_20570	COG1263	PTS System
DS740_20575	COG2116	formate transmembrane transporter activity
DS740_20580	COG3711	transcriptional antiterminator
DS740_20590	COG1404	Belongs to the peptidase S8 family
DS740_20595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DS740_20600	COG0778	Nitroreductase
DS740_20605	COG0772	Belongs to the SEDS family
DS740_20615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DS740_20620	COG1845	cytochrome c oxidase, subunit III
DS740_20625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DS740_20630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DS740_20635	COG2261	transglycosylase associated protein
DS740_20640	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DS740_20645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DS740_20650	COG2246	polysaccharide biosynthetic process
DS740_20655	COG1309	transcriptional regulator
DS740_20665	COG3162	membrane
DS740_20670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DS740_20675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DS740_20680	COG2837	iron assimilation
DS740_20685	COG2822	iron ion transport
DS740_20690	COG0672	)-iron permease
DS740_20695	COG0352	thiamine-phosphate diphosphorylase activity
DS740_20700	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DS740_20705	COG0583	DNA-binding transcription factor activity
DS740_20710	COG1380	Effector of murein hydrolase LrgA
DS740_20715	COG1346	cytolysis
DS740_20720	COG2814	Major facilitator Superfamily
DS740_20725	COG4895	conserved protein (DUF2196)
DS740_20730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DS740_20735	COG0346	lactoylglutathione lyase activity
DS740_20740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DS740_20745	COG1404	Belongs to the peptidase S8 family
DS740_20750	COG1263	PTS System
DS740_20750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_20755	COG3711	transcriptional antiterminator
DS740_20760	COG1442	glycosyl transferase family 8
DS740_20765	COG5522	Integral membrane protein (intg_mem_TP0381)
DS740_20770	COG1846	Transcriptional regulator
DS740_20775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DS740_20780	COG2234	aminopeptidase activity
DS740_20795	COG2814	Major facilitator Superfamily
DS740_20800	COG2357	RelA SpoT domain protein
DS740_20805	COG1575	Belongs to the MenA family. Type 1 subfamily
DS740_20820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DS740_20825	COG1696	Membrane protein involved in D-alanine export
DS740_20830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DS740_20835	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DS740_20840	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DS740_20845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DS740_20850	COG1486	melibiose metabolic process
DS740_20855	COG1447	Phosphotransferase system cellobiose-specific component IIA
DS740_20860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DS740_20865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DS740_20870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DS740_20870	COG3711	transcriptional antiterminator
DS740_20880	COG2094	Belongs to the DNA glycosylase MPG family
DS740_20885	COG0753	catalase activity
DS740_20890	COG2814	Major facilitator Superfamily
DS740_20895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DS740_20900	COG1131	(ABC) transporter
DS740_20920	COG1595	DNA-templated transcription, initiation
DS740_20925	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DS740_20930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DS740_20935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DS740_20940	COG4988	ABC transporter
DS740_20945	COG1294	oxidase, subunit
DS740_20950	COG1271	oxidase subunit
DS740_20955	COG3493	citrate carrier protein
DS740_20960	COG0501	Belongs to the peptidase M48B family
DS740_20970	COG0726	polysaccharide deacetylase
DS740_20985	COG3842	ATPase activity
DS740_20990	COG2508	Transcriptional regulator
DS740_20995	COG1012	belongs to the aldehyde dehydrogenase family
DS740_21000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DS740_21015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DS740_21020	COG1881	PFAM PEBP family protein
DS740_21025	COG0583	DNA-binding transcription factor activity
DS740_21035	COG4585	Histidine kinase
DS740_21040	COG2197	response regulator
DS740_21045	COG2195	Cleaves the N-terminal amino acid of tripeptides
DS740_21055	COG4894	glucomannan catabolic process
DS740_21060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DS740_21065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DS740_21070	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_21075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DS740_21080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DS740_21085	COG2610	gluconate transmembrane transporter activity
DS740_21090	COG0500	methyltransferase
DS740_21095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DS740_21110	COG0693	protein deglycase activity
DS740_21110	COG0753	catalase activity
DS740_21115	COG2851	Citrate transporter
DS740_21120	COG2273	Hydrolase Family 16
DS740_21125	COG3711	transcriptional antiterminator
DS740_21135	COG2270	Major facilitator Superfamily
DS740_21140	COG0513	Belongs to the DEAD box helicase family
DS740_21145	COG3401	FG-GAP repeat protein
DS740_21145	COG2755	lipolytic protein G-D-S-L family
DS740_21190	COG3209	COG3209 Rhs family protein
DS740_21195	COG0697	spore germination
DS740_21200	COG0589	response to stress
DS740_21205	COG2723	6-phospho-beta-galactosidase activity
DS740_21210	COG1263	PTS System
DS740_21210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_21210	COG2190	(PTS) system
DS740_21255	COG3507	Belongs to the glycosyl hydrolase 43 family
DS740_21270	COG2986	histidine ammonia-lyase
DS740_21275	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DS740_21280	COG1228	amidohydrolase
DS740_21285	COG0010	Belongs to the arginase family
DS740_21290	COG0833	amino acid
DS740_21295	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DS740_21300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DS740_21305	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DS740_21310	COG2390	Transcriptional regulator
DS740_21320	COG3192	ethanolamine utilization protein
DS740_21325	COG2079	MmgE PrpD family protein
DS740_21335	COG1126	abc transporter atp-binding protein
DS740_21340	COG0765	amino acid transport
DS740_21345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DS740_21360	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DS740_21365	COG0561	phosphatase activity
DS740_21395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DS740_21400	COG5294	Protein conserved in bacteria
DS740_21405	COG0577	efflux transmembrane transporter activity
DS740_21410	COG1136	(ABC) transporter
DS740_21415	COG2205	protein histidine kinase activity
DS740_21420	COG0745	RESPONSE REGULATOR receiver
DS740_21425	COG0191	fructose-bisphosphate aldolase activity
DS740_21430	COG1082	Xylose isomerase domain protein TIM barrel
DS740_21435	COG1082	Xylose isomerase domain protein TIM barrel
DS740_21440	COG0673	inositol 2-dehydrogenase activity
DS740_21445	COG2814	Major facilitator Superfamily
DS740_21450	COG1082	Xylose isomerase domain protein TIM barrel
DS740_21455	COG3962	Belongs to the TPP enzyme family
DS740_21460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DS740_21470	COG1012	belongs to the aldehyde dehydrogenase family
DS740_21475	COG1349	DNA-binding transcription factor activity
DS740_21480	COG0667	Aldo Keto reductase
DS740_21495	COG2814	Major facilitator Superfamily
DS740_21500	COG0326	Molecular chaperone. Has ATPase activity
DS740_21510	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_21540	COG1309	transcriptional regulator
DS740_21545	COG1012	belongs to the aldehyde dehydrogenase family
DS740_21550	COG1714	RDD family
DS740_21555	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DS740_21565	COG1714	RDD family
DS740_21570	COG2311	Membrane
DS740_21575	COG1917	Cupin 2, conserved barrel domain protein
DS740_21580	COG1309	transcriptional regulator
DS740_21585	COG1028	Short-chain dehydrogenase reductase Sdr
DS740_21590	COG1846	Transcriptional regulator
DS740_21595	COG1380	Effector of murein hydrolase LrgA
DS740_21600	COG1346	cytolysis
DS740_21605	COG5039	Polysaccharide pyruvyl transferase
DS740_21610	COG1929	Belongs to the glycerate kinase type-1 family
DS740_21615	COG1802	Transcriptional regulator
DS740_21620	COG1070	Carbohydrate kinase
DS740_21625	COG2610	gluconate transmembrane transporter activity
DS740_21630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DS740_21635	COG0450	alkyl hydroperoxide reductase
DS740_21640	COG3634	alkyl hydroperoxide reductase activity
DS740_21660	COG1263	PTS System
DS740_21660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DS740_21665	COG2188	Transcriptional regulator
DS740_21680	COG1131	(ABC) transporter
DS740_21685	COG1994	Peptidase M50
DS740_21690	COG0535	radical SAM domain protein
DS740_21700	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DS740_21710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DS740_21725	COG1063	alcohol dehydrogenase
DS740_21745	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DS740_21750	COG0456	acetyltransferase
DS740_21755	COG0457	Tetratricopeptide repeat
DS740_21765	COG0010	Belongs to the arginase family
DS740_21770	COG0833	amino acid
DS740_21775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DS740_21780	COG3829	transcription factor binding
DS740_21790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DS740_21795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DS740_21800	COG4853	Protein conserved in bacteria
DS740_21805	COG4863	YycH protein
DS740_21810	COG5002	protein histidine kinase activity
DS740_21815	COG0745	RESPONSE REGULATOR receiver
DS740_21845	COG0346	lactoylglutathione lyase activity
DS740_21850	COG0305	Participates in initiation and elongation during chromosome replication
DS740_21865	COG3093	addiction module antidote protein HigA
DS740_21870	COG2807	transmembrane transport
DS740_21875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DS740_21880	COG0359	binds to the 23S rRNA
DS740_21885	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DS740_21890	COG4241	membrane
DS740_21900	COG5577	PFAM Coat F domain
DS740_21905	COG1733	regulation of RNA biosynthetic process
DS740_21910	COG1227	inorganic diphosphatase activity
DS740_21925	COG2271	Major facilitator Superfamily
DS740_21930	COG0789	Transcriptional regulator
DS740_21930	COG4978	Transcriptional regulator
DS740_21940	COG4319	ketosteroid isomerase
DS740_21950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DS740_21955	COG1846	Transcriptional regulator
DS740_21960	COG2153	protein acetylation
DS740_21965	COG2364	Membrane
DS740_21970	COG0456	acetyltransferase
DS740_21975	COG2315	Protein conserved in bacteria
DS740_21980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DS740_22000	COG0789	Transcriptional regulator
DS740_22005	COG0697	spore germination
DS740_22010	COG1331	Highly conserved protein containing a thioredoxin domain
DS740_22015	COG1266	CAAX protease self-immunity
DS740_22020	COG2814	Major facilitator Superfamily
DS740_22020	COG0477	Major facilitator Superfamily
DS740_22025	COG0110	maltose O-acetyltransferase activity
DS740_22030	COG0346	lactoylglutathione lyase activity
DS740_22035	COG1609	Transcriptional regulator
DS740_22040	COG0708	Exodeoxyribonuclease III
DS740_22045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DS740_22050	COG0629	single-stranded DNA binding
DS740_22055	COG0360	Binds together with S18 to 16S ribosomal RNA
DS740_22060	COG0012	GTP binding
DS740_22065	COG0243	molybdopterin cofactor binding
DS740_22070	COG4481	Protein conserved in bacteria
DS740_22075	COG3949	Membrane
DS740_22085	COG1475	DNA binding
DS740_22090	COG1192	Involved in chromosome partitioning
DS740_22100	COG1475	DNA binding
DS740_22105	COG0357	Ribosomal RNA small subunit methyltransferase G
DS740_22110	COG0445	tRNA wobble uridine modification
DS740_22115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DS740_22120	COG1847	R3H domain protein
DS740_22125	COG0706	membrane insertase activity
DS740_22130	COG0594	ribonuclease P activity
DS740_22135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DS740_22145	COG0587	DNA-directed DNA polymerase activity
DS740_22165	COG0328	RNA-DNA hybrid ribonuclease activity
DS740_22200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DS740_22240	COG0716	FMN binding
DS740_22245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS740_22250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DS740_22255	COG2887	Belongs to the helicase family. UvrD subfamily
DS740_22325	COG0582	viral genome integration into host DNA
DS740_22340	COG1388	LysM domain
DS740_22340	COG3584	3D domain protein
DS740_22360	COG0457	Tetratricopeptide repeat
DS740_22450	COG5280	Phage tail tape measure protein TP901
DS740_22450	COG3953	SLT domain
DS740_22505	COG5444	nuclease activity
DS740_22570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DS740_22575	COG0187	DNA topoisomerase II activity
DS740_22620	COG0194	GDP metabolic process