locus-tag class description C3Y97_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C3Y97_00015 ENOG410848D S4 domain protein YaaA C3Y97_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3Y97_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C3Y97_00100 ENOG4105ZMH deoxynucleoside kinase C3Y97_00110 ENOG4105GTG Isochorismatase C3Y97_00120 ENOG4108Z6B deaminase C3Y97_00130 ENOG4105C6E dna polymerase iii C3Y97_00150 ENOG41067KS pro-sigma K processing C3Y97_00185 ENOG4105CXN decarboxylase C3Y97_00195 ENOG4105FA2 dna polymerase iii C3Y97_00200 ENOG4105MA4 psp1 domain protein C3Y97_00210 ENOG41060K3 Methyltransferase C3Y97_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C3Y97_00225 ENOG4105KRN Transcriptional regulator, abrb family C3Y97_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C3Y97_00235 ENOG4105F8V Hydrolase, tatD family C3Y97_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) C3Y97_00250 ENOG4105XFA sporulation peptidase YabG C3Y97_00255 ENOG4105W42 Veg protein C3Y97_00270 ENOG4105DFT pur operon repressor C3Y97_00275 ENOG4105KME endoribonuclease L-psp C3Y97_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C3Y97_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C3Y97_00305 ENOG4108JA2 transcriptioN-repair coupling factor C3Y97_00310 ENOG4108M14 stage v sporulation protein t C3Y97_00320 ENOG4108IY2 MazG family C3Y97_00325 ENOG41082I2 s4 domain protein C3Y97_00330 ENOG4105VYY sporulation protein yabp C3Y97_00345 ENOG41060GV RNA binding s1 domain protein C3Y97_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C3Y97_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase C3Y97_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C3Y97_00390 ENOG4105C6T cysteine synthase C3Y97_00395 ENOG4105CRQ synthase (Component I) C3Y97_00400 ENOG4105DDQ anthranilate synthase C3Y97_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C3Y97_00410 ENOG4105EEI dihydropteroate synthase C3Y97_00415 ENOG4105KRF dihydroneopterin aldolase C3Y97_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C3Y97_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C3Y97_00520 ENOG4108Z0C Uvrb UvrC protein C3Y97_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C3Y97_00540 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C3Y97_00545 ENOG4105CTP PilT protein domain protein C3Y97_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C3Y97_00565 ENOG4105D7W serine acetyltransferase C3Y97_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 C3Y97_00585 ENOG4105M0M Tetracycline resistance protein C3Y97_00590 ENOG4105QIV RNA polymerase C3Y97_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C3Y97_00630 ENOG4107Y49 methyltransferase C3Y97_00645 ENOG4105XPM ribosomal protein C3Y97_00755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C3Y97_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C3Y97_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C3Y97_00800 ENOG41067V7 50S ribosomal protein L36 C3Y97_00825 ENOG4108JJB ABC transporter C3Y97_00830 ENOG4108JJB ABC transporter C3Y97_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C3Y97_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C3Y97_00865 ENOG4105D1F ATP-binding protein C3Y97_00880 ENOG4108NMV polysaccharide deacetylase C3Y97_00960 ENOG4105C8B TIGR00159 family C3Y97_00965 ENOG4107U5W ybbr family C3Y97_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C3Y97_01005 ENOG4108PSK reductase C3Y97_01010 ENOG4108UMI ABC transporter, permease C3Y97_01015 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C3Y97_01020 ENOG4105D01 (LipO)protein C3Y97_01025 ENOG4105EE1 crotonyl-CoA reductase C3Y97_01035 ENOG4105IQ5 FAD linked oxidase domain protein C3Y97_01050 ENOG4105C2C drug resistance transporter, Bcr CflA C3Y97_01070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3Y97_01075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3Y97_01080 ENOG4105C3U ABC transporter C3Y97_01085 ENOG4108JQ7 (ABC) transporter C3Y97_01115 ENOG4108J59 Extracellular solute-binding protein, family 5 C3Y97_01120 ENOG4108J59 Extracellular solute-binding protein, family 5 C3Y97_01140 ENOG4105E0C molybdate abc transporter C3Y97_01145 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C3Y97_01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C3Y97_01165 ENOG4105EGI Transcriptional regulator C3Y97_01185 ENOG4105F6E Acyl-transferase C3Y97_01210 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C3Y97_01230 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C3Y97_01255 ENOG4105C5H ABC transporter C3Y97_01270 ENOG4105DEF Extracellular solute-binding protein, family 5 C3Y97_01280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3Y97_01285 ENOG4105C3U ABC transporter C3Y97_01290 ENOG4108JQ7 (ABC) transporter C3Y97_01295 ENOG410667J hydrolase C3Y97_01325 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase C3Y97_01330 ENOG4105ERH Fumarylacetoacetate hydrolase C3Y97_01340 ENOG4105CUB amino acid C3Y97_01345 ENOG4108SC4 )-transporter C3Y97_01350 ENOG4105CPF Cell wall formation (By similarity) C3Y97_01355 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C3Y97_01380 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C3Y97_01385 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C3Y97_01395 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C3Y97_01500 ENOG4105K8N protein family UPF0079, ATPase C3Y97_01505 ENOG41072GX Peptidase M22 Glycoprotease C3Y97_01510 ENOG410801F ribosomal-protein-alanine acetyltransferase C3Y97_01515 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C3Y97_01520 ENOG4105C5H ABC transporter C3Y97_01535 ENOG4108TYN CAAX amino terminal protease family protein C3Y97_01550 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C3Y97_01555 ENOG4105C7N Xanthine uracil vitamin C permease C3Y97_01565 ENOG4105BZU Histidine kinase C3Y97_01595 ENOG4107ZXU DSBA oxidoreductase C3Y97_01645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3Y97_01675 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3Y97_01685 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C3Y97_01695 ENOG4108SHN Glycosyl transferase, family 2 C3Y97_01715 ENOG4105SX7 Transporter C3Y97_01745 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C3Y97_01750 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C3Y97_01755 ENOG4105C83 adenylosuccinate lyase C3Y97_01765 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C3Y97_01790 ENOG4108V3E phosphoribosylglycinamide formyltransferase C3Y97_01795 ENOG4105DC1 bifunctional purine biosynthesis protein purh C3Y97_01800 ENOG4105C12 Phosphoribosylglycinamide synthetase C3Y97_01830 ENOG4105C4R Atp-dependent dna helicase C3Y97_01835 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C3Y97_01855 ENOG4108W2Y isochorismatase C3Y97_01860 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C3Y97_01865 ENOG4108UMI ABC transporter, permease C3Y97_01870 ENOG4105D01 (LipO)protein C3Y97_01890 ENOG410834F Transcriptional regulator C3Y97_01895 ENOG4107I77 yiaA/B two helix domain C3Y97_01905 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3Y97_01915 ENOG4105CBD Diacylglycerol kinase C3Y97_01925 ENOG4108JPW Aminotransferase C3Y97_01935 ENOG4105C26 Dehydrogenase C3Y97_01940 ENOG4105KPY Small multidrug resistance protein C3Y97_01965 ENOG4105D9N nucleoside C3Y97_01970 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C3Y97_01980 ENOG4108W15 Protein of unknown function (DUF1456) C3Y97_01995 ENOG4105DTQ mandelate racemase muconate lactonizing C3Y97_02005 ENOG4105DFD Na H antiporter C3Y97_02025 ENOG4105D3R alkyl hydroperoxide reductase C3Y97_02030 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C3Y97_02035 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C3Y97_02040 ENOG4107W7X Aldolase C3Y97_02045 ENOG4105EHG Permease protein C3Y97_02050 ENOG4105DQ5 transport system permease protein C3Y97_02055 ENOG4108V5C ABC transporter C3Y97_02065 ENOG4105CAY ferredoxin--nadp reductase C3Y97_02085 ENOG4106UIA C3Y97_02090 ENOG4106UIA C3Y97_02105 ENOG4105BZU Histidine kinase C3Y97_02125 ENOG410756H nucleotidyltransferase C3Y97_02130 ENOG4105D2S major facilitator superfamily C3Y97_02145 ENOG4105E5Q amino acid AbC transporter C3Y97_02150 ENOG4105EAB amino acid AbC transporter C3Y97_02155 ENOG4105CDA abc transporter atp-binding protein C3Y97_02160 ENOG4105C8Q Methyl-accepting chemotaxis C3Y97_02175 ENOG4105DBV ornithine carbamoyltransferase C3Y97_02185 ENOG4105C5B carbamate kinase C3Y97_02190 ENOG4108W63 CRP FNR family transcriptional regulator C3Y97_02200 ENOG4105DNP FAD linked oxidase domain protein C3Y97_02210 ENOG4105CI1 PTS System C3Y97_02225 ENOG4105C9U ATP-dependent DNA helicase RecQ C3Y97_02230 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase C3Y97_02240 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C3Y97_02260 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C3Y97_02265 ENOG4105D2X ABC transporter substrate-binding protein C3Y97_02310 ENOG41062JF Transcriptional regulator C3Y97_02325 ENOG4105DEU major facilitator superfamily C3Y97_02340 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C3Y97_02355 ENOG4108N0M stress protein C3Y97_02360 ENOG4106FN3 tellurium resistance protein C3Y97_02365 ENOG4106FN3 tellurium resistance protein C3Y97_02370 ENOG4107TS3 membrane protein, TerC C3Y97_02375 ENOG4108TTB tellurium resistance protein C3Y97_02390 ENOG41068PA UPF0435 protein C3Y97_02395 ENOG4105KJF protein tyrosine phosphatase C3Y97_02405 ENOG4107U9T Pfam:Ribonuclease_BN C3Y97_02415 ENOG4105C59 p-type ATPase C3Y97_02420 ENOG4108IPJ Membrane C3Y97_02430 ENOG4105C3F Signal peptidase i C3Y97_02440 ENOG4107ZTW SNARE associated Golgi C3Y97_02455 ENOG410606W general stress protein C3Y97_02460 ENOG4105UPD Calcium Proton C3Y97_02495 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C3Y97_02510 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C3Y97_02520 ENOG4108JUB Transcriptional regulator C3Y97_02530 ENOG4108IQI permease C3Y97_02575 ENOG4108A04 Beta-lactamase C3Y97_02590 ENOG4105CKK Glycosyl transferase, family 2 C3Y97_02595 ENOG4107QQG Dehydrogenase C3Y97_02600 ENOG4105C3I Nad-dependent epimerase dehydratase C3Y97_02620 ENOG4105F1A Pyruvate formate-lyase C3Y97_02625 ENOG4108QBV Monogalactosyldiacylglycerol synthase C3Y97_02640 ENOG4105CI2 imidazolone-5-propionate hydrolase C3Y97_02645 ENOG4105ECP epimerase C3Y97_02675 ENOG41067AE Membrane-bound metal-dependent hydrolase C3Y97_02680 ENOG4105CEN a g-specific adenine glycosylase C3Y97_02685 ENOG4106BXE C3Y97_02705 ENOG4105BZ1 (ABC) transporter C3Y97_02710 ENOG4107NBY Membrane C3Y97_02715 ENOG4105CBC glutamate synthase C3Y97_02725 ENOG4108IUW ABC transporter C3Y97_02745 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3Y97_02750 ENOG4105G5W regulator Fur family C3Y97_02865 ENOG4105CDY transcriptional regulatory protein C3Y97_02875 ENOG4108JQC penicillin-binding protein 1A C3Y97_02880 ENOG4108R9S DSBA oxidoreductase C3Y97_02890 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C3Y97_02900 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C3Y97_02905 ENOG4105BZU Histidine kinase C3Y97_02915 ENOG4105CYN Serine protein kinase C3Y97_02930 ENOG4106AKX UPF0229 protein C3Y97_02945 ENOG4105C94 Transporter C3Y97_02960 ENOG4105DZ6 Band 7 protein C3Y97_02970 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C3Y97_02975 ENOG4108V9W transcriptional regulatory protein C3Y97_02980 ENOG4105D4T Citrate transporter C3Y97_03005 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C3Y97_03010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C3Y97_03015 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C3Y97_03020 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component C3Y97_03025 ENOG4105BZ7 extracellular solute-binding protein family 1 C3Y97_03030 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C3Y97_03035 ENOG4108STX response regulator C3Y97_03040 ENOG4105US7 Histidine kinase C3Y97_03065 ENOG4108MRH transcriptional regulatory protein C3Y97_03075 ENOG4105C6K Malic enzyme C3Y97_03085 ENOG4108UZ3 Transporter C3Y97_03090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3Y97_03100 ENOG4105BZU Histidine kinase C3Y97_03120 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C3Y97_03125 ENOG4108JB9 formate dehydrogenase C3Y97_03145 ENOG4105CUB amino acid C3Y97_03165 ENOG4105C59 p-type ATPase C3Y97_03170 ENOG4105DAP Nicotinate phosphoribosyltransferase C3Y97_03205 ENOG41073R8 VanW family C3Y97_03210 ENOG4108KGH TRANSCRIPTIONal C3Y97_03215 ENOG4105D9N nucleoside C3Y97_03220 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C3Y97_03225 ENOG4105C37 (CBS) domain C3Y97_03230 ENOG4108IJ0 Aspartate ammonia-lyase C3Y97_03235 ENOG4105DAA L-lactate C3Y97_03250 ENOG4105DUX Transporter C3Y97_03255 ENOG4108MES Periplasmic binding protein C3Y97_03260 ENOG4105DQ5 transport system permease protein C3Y97_03265 ENOG4108IHU transport system permease protein C3Y97_03270 ENOG4105E0A ABC, transporter C3Y97_03280 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C3Y97_03285 ENOG4105EXW epimerase dehydratase C3Y97_03295 ENOG4107T89 von Willebrand factor, type A C3Y97_03300 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C3Y97_03305 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3Y97_03315 ENOG4105BZU Histidine kinase C3Y97_03320 ENOG4105D5Q Arginine ornithine antiporter C3Y97_03325 ENOG4107414 GntR family transcriptional regulator C3Y97_03330 ENOG4105C5Y PTS System C3Y97_03335 ENOG4105CG3 alpha amylase, catalytic region C3Y97_03350 ENOG4105E1K spore germination protein C3Y97_03360 ENOG4105CRN Aminoglycoside phosphotransferase C3Y97_03365 ENOG4105BZG amino acid carrier protein C3Y97_03375 ENOG4105CDA abc transporter atp-binding protein C3Y97_03380 ENOG4105CT1 (ABC) transporter C3Y97_03385 ENOG4105EAD ABC transporter C3Y97_03390 ENOG4105DRP amino acid AbC transporter C3Y97_03395 ENOG4108IQI permease C3Y97_03420 ENOG4105D29 Helix-turn-helix type 11 domain protein C3Y97_03425 ENOG4105NAE bifunctional deaminase-reductase domain protein C3Y97_03430 ENOG4105BZU Histidine kinase C3Y97_03455 ENOG4105CHH sulfate transporter C3Y97_03460 ENOG41068KF Universal stress protein C3Y97_03470 ENOG4105CXY transporter C3Y97_03475 ENOG41067TZ transcriptional regulator, MarR family C3Y97_03480 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3Y97_03485 ENOG4105ETE Transcriptional regulator (LacI family C3Y97_03490 ENOG4108RVA ribokinase C3Y97_03500 ENOG4105C2J ABC transporter C3Y97_03505 ENOG4105CNN ABC, transporter C3Y97_03510 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C3Y97_03515 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C3Y97_03550 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) C3Y97_03580 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C3Y97_03585 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C3Y97_03590 ENOG41069ER domain protein C3Y97_03595 ENOG4105VZ8 Transcriptional regulator C3Y97_03600 ENOG4107D63 C3Y97_03615 ENOG4105DUX Transporter C3Y97_03635 ENOG4105C85 amino acid C3Y97_03640 ENOG4105C7N Xanthine uracil vitamin C permease C3Y97_03655 ENOG4105MA6 gCN5-related N-acetyltransferase C3Y97_03680 ENOG4105BZ9 Cytochrome C oxidase, subunit I C3Y97_03685 ENOG4105E2S oxidase) subunit II C3Y97_03705 ENOG4106CAD Protein of unknown function (DUF3311) C3Y97_03710 ENOG4105E1V na solute symporter C3Y97_03725 ENOG4108NHD germination protein C3Y97_03735 ENOG4105CE1 Ferrous iron transport protein b C3Y97_03740 ENOG4105CE1 Ferrous iron transport protein b C3Y97_03745 ENOG4105CE1 Ferrous iron transport protein b C3Y97_03750 ENOG4105CVA phosphate C3Y97_03755 ENOG4105C8U phosphate abc transporter C3Y97_03760 ENOG4105E2Z phosphate ABC transporter (Permease C3Y97_03890 ENOG41080XQ Signal transduction protein with cbs domains C3Y97_03915 ENOG4105ETU transcriptional activator (TenA C3Y97_03925 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C3Y97_03935 ENOG4108VEU Thiamine monophosphate synthase C3Y97_03940 ENOG41080HI glycine oxidase C3Y97_03955 ENOG4105D06 uba thif-type nad fad binding protein C3Y97_03960 ENOG4105DWF phosphomethylpyrimidine kinase C3Y97_03990 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C3Y97_03995 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) C3Y97_04010 ENOG4108INS Transcriptional regulator C3Y97_04035 ENOG4105C19 ABC transporter C3Y97_04050 ENOG4105CNN ABC, transporter C3Y97_04065 ENOG4105C7N Xanthine uracil vitamin C permease C3Y97_04075 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C3Y97_04095 ENOG4105C5Y PTS System C3Y97_04110 ENOG4105K63 Thioredoxin C3Y97_04130 ENOG4108B31 Spore germination protein C3Y97_04150 ENOG4107Y03 Nitroreductase C3Y97_04155 ENOG4105ED1 spovr family C3Y97_04165 ENOG4105J4Q Transcriptional regulator C3Y97_04180 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C3Y97_04185 ENOG4105XTG Pfam:DUF156 C3Y97_04190 ENOG4105VFE sira family C3Y97_04195 ENOG4107TPS domain protein C3Y97_04200 ENOG4105VFE sira family C3Y97_04205 ENOG4105VFE sira family C3Y97_04210 ENOG41085GJ domain protein C3Y97_04215 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C3Y97_04220 ENOG41087NI Sulfite exporter TauE/SafE C3Y97_04230 ENOG4108KGH TRANSCRIPTIONal C3Y97_04260 ENOG4105EMD TRANSCRIPTIONal C3Y97_04265 ENOG4105VCP PTS System C3Y97_04270 ENOG4105VZJ PTS System C3Y97_04295 ENOG41069ER domain protein C3Y97_04300 ENOG4107RBB ABC transporter, permease C3Y97_04305 ENOG4105C19 ABC transporter C3Y97_04335 ENOG4105WEF catalase C3Y97_04370 ENOG4107T5V SNARE associated Golgi C3Y97_04405 ENOG4105CUB amino acid C3Y97_04410 ENOG4107RWR Sodium hydrogen exchanger C3Y97_04420 ENOG4106KNT transcriptional regulator C3Y97_04425 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C3Y97_04460 ENOG4108YXU transcriptional regulator AsnC family C3Y97_04465 ENOG4105CH7 arginosuccinase C3Y97_04470 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3Y97_04480 ENOG4105KPY Small multidrug resistance protein C3Y97_04540 ENOG4107RKG DJ-1/PfpI family C3Y97_04545 ENOG4105CH6 catalase C3Y97_04555 ENOG4105D5Q Arginine ornithine antiporter C3Y97_04560 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C3Y97_04570 ENOG4105C26 Dehydrogenase C3Y97_04590 ENOG4105BZ1 (ABC) transporter C3Y97_04595 ENOG4105BZ1 (ABC) transporter C3Y97_04610 ENOG4105DRP amino acid AbC transporter C3Y97_04615 ENOG4105CDA abc transporter atp-binding protein C3Y97_04630 ENOG410839P C3Y97_04640 ENOG4108UH6 UPF0754 membrane protein C3Y97_04665 ENOG4107FQX Alpha-acetolactate decarboxylase C3Y97_04670 ENOG4108VX5 3-methyladenine DNA glycosylase C3Y97_04685 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C3Y97_04690 ENOG4105D4P Coproporphyrinogen iii oxidase C3Y97_04700 ENOG4105CEY Amp-dependent synthetase and ligase C3Y97_04715 ENOG4105CHH sulfate transporter C3Y97_04740 ENOG4105CGU Enoyl-CoA hydratase C3Y97_04760 ENOG4105DER m42 family C3Y97_04780 ENOG4105CTU Proline racemase C3Y97_04785 ENOG4105CIF Ornithine Cyclodeaminase C3Y97_04805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3Y97_04815 ENOG4108JQ7 (ABC) transporter C3Y97_04880 ENOG4108IBT Inherit from COG: transposase C3Y97_04935 ENOG4105CSH Transporter C3Y97_04945 ENOG4108MRH transcriptional regulatory protein C3Y97_05000 ENOG4105CVR type I restriction-modification system C3Y97_05010 ENOG4105DZR Type I site-specific deoxyribonuclease C3Y97_05040 ENOG4105CDU Replicative dna helicase C3Y97_05070 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3Y97_05100 ENOG4105F6J Alpha beta hydrolase fold C3Y97_05150 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C3Y97_05165 ENOG4105CMT Dihydroxyacetone kinase C3Y97_05180 ENOG4105CMT Dihydroxyacetone kinase C3Y97_05280 ENOG4105WN5 stage II sporulation protein C3Y97_05290 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3Y97_05300 ENOG4108MJI response regulator C3Y97_05305 ENOG4105BZU Histidine kinase C3Y97_05310 ENOG4105BZU Histidine kinase C3Y97_05335 ENOG4105K8R UPF0145 protein C3Y97_05355 ENOG4107QHE Choloylglycine hydrolase C3Y97_05375 ENOG4107VRP DNA repair exonuclease C3Y97_05380 ENOG4106D4I domain protein C3Y97_05395 ENOG410829K Lysine exporter protein (Lyse ygga) C3Y97_05420 ENOG4108MUZ hydrolase C3Y97_05440 ENOG4105F0F Oxalate decarboxylase C3Y97_05445 ENOG41067QW Transcriptional regulator C3Y97_05450 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C3Y97_05465 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C3Y97_05490 ENOG4105EEM helicase C3Y97_05500 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3Y97_05530 ENOG4105K59 histidine triad (HIT) protein C3Y97_05570 ENOG410905X membrane-flanked domain protein C3Y97_05575 ENOG4105CKV Membrane C3Y97_05615 ENOG410905X membrane-flanked domain protein C3Y97_05620 ENOG4105CKV Membrane C3Y97_05625 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C3Y97_05630 ENOG4105BZ4 penicillin-binding protein C3Y97_05640 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C3Y97_05645 ENOG4105C1Q protoporphyrinogen oxidase C3Y97_05670 ENOG4105NA0 Transcriptional regulator C3Y97_05685 ENOG4105ECB domain protein C3Y97_05685 ENOG4105ECB domain protein C3Y97_05715 ENOG4108MK9 spermidine N(1)-acetyltransferase C3Y97_05725 ENOG4106AXD C3Y97_05730 ENOG4108RQ5 Beta-lactamase domain-containing protein C3Y97_05735 ENOG4105DF9 Lipoate-protein, ligase C3Y97_05745 ENOG4105CEY Amp-dependent synthetase and ligase C3Y97_05755 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C3Y97_05760 ENOG4108I5D sulfate abc transporter C3Y97_05765 ENOG4105ECW sulfate abc transporter C3Y97_05770 ENOG4108IJ6 ABC transporter C3Y97_05775 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) C3Y97_05785 ENOG4107RN3 metallophosphoesterase C3Y97_05790 ENOG4107TVP HD domain protein C3Y97_05800 ENOG4108AEY RNA polymerase sigma factor C3Y97_05805 ENOG41086D8 Transcriptional regulator C3Y97_05820 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3Y97_05840 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C3Y97_05845 ENOG4105C8Q Methyl-accepting chemotaxis C3Y97_05850 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) C3Y97_05860 ENOG4107QP3 malate synthase g C3Y97_05880 ENOG4105VEQ Cold shock protein C3Y97_05915 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C3Y97_05960 ENOG4105ERH Fumarylacetoacetate hydrolase C3Y97_05970 ENOG4105C8Y Acetylornithine aminotransferase C3Y97_05975 ENOG4106BKT UPF0344 protein C3Y97_05985 ENOG4105CAQ asparagine synthetase C3Y97_05990 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C3Y97_05995 ENOG4105CH6 catalase C3Y97_06000 ENOG4105BZU Histidine kinase C3Y97_06020 ENOG4108VPT UPF0234 protein C3Y97_06025 ENOG4105QNR S1 RNA binding domain protein C3Y97_06030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3Y97_06040 ENOG4107AYK membrAne C3Y97_06045 ENOG41073B9 C3Y97_06055 ENOG4108KP7 hydrolase C3Y97_06070 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C3Y97_06095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3Y97_06100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C3Y97_06115 ENOG4105C31 Tryptophanyl-tRNA synthetase C3Y97_06135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3Y97_06140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3Y97_06150 ENOG4108JQ7 (ABC) transporter C3Y97_06155 ENOG4105UQX Mate efflux family protein C3Y97_06180 ENOG4108ZCF integral membrane protein C3Y97_06190 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3Y97_06200 ENOG4105DPN Oligoendopeptidase f C3Y97_06215 ENOG4108Z18 K06886 hemoglobin C3Y97_06220 ENOG4105MIX Adenylate cyclase C3Y97_06225 ENOG4106EFP UPF0738 protein C3Y97_06235 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C3Y97_06240 ENOG4105EMS pseudouridine synthase C3Y97_06260 ENOG4105K64 Glycosyl transferase, family 2 C3Y97_06285 ENOG4107TVC Glycosyl transferase, family 2 C3Y97_06305 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C3Y97_06310 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C3Y97_06320 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C3Y97_06370 ENOG4108ZMI UPF0477 protein C3Y97_06395 ENOG4105CK7 Sodium proline symporter C3Y97_06405 ENOG4105CRQ synthase (Component I) C3Y97_06410 ENOG4105DDQ anthranilate synthase C3Y97_06420 ENOG4105DK0 Indole-3-glycerol phosphate synthase C3Y97_06430 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C3Y97_06435 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C3Y97_06505 ENOG4105C7S Dehydrogenase C3Y97_06565 ENOG4105DZ1 carboxypeptidase C3Y97_06570 ENOG4105VFR signal peptidase C3Y97_06605 ENOG4105C26 Dehydrogenase C3Y97_06610 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C3Y97_06615 ENOG4105F38 ABC transporter, permease C3Y97_06620 ENOG4105D38 putrescine abc transporter C3Y97_06625 ENOG4107RUE extracellular solute-binding protein family 1 C3Y97_06635 ENOG4105EYF MMPL domain protein C3Y97_06645 ENOG4108YBP pseudouridine synthase C3Y97_06655 ENOG4105K4I Scp-like extracellular C3Y97_06660 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C3Y97_06665 ENOG4105CQB FAD linked oxidase domain protein C3Y97_06680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_06685 ENOG4105BZU Histidine kinase C3Y97_06690 ENOG4105JXH GntR family transcriptional regulator C3Y97_06710 ENOG4106A3R peptidase C3Y97_06720 ENOG4108QTI )-transporter C3Y97_06725 ENOG4107TS3 membrane protein, TerC C3Y97_06730 ENOG4105CZN Potassium uptake protein C3Y97_06735 ENOG410681C small acid-soluble spore protein C3Y97_06740 ENOG4108Z7G MaoC domain protein dehydratase C3Y97_06760 ENOG4105CHR reductase C3Y97_06795 ENOG4105C4Y ABC transporter C3Y97_06800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C3Y97_06805 ENOG4107RCV ABC transporter, permease C3Y97_06825 ENOG4105E98 transcriptional regulator DeoR family C3Y97_06840 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C3Y97_06850 ENOG4105PXI polysaccharide deacetylase C3Y97_06860 ENOG4105BZU Histidine kinase C3Y97_06865 ENOG41090MY MarR family Transcriptional regulator C3Y97_06875 ENOG4106DF1 C3Y97_06885 ENOG4105BZU Histidine kinase C3Y97_06890 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C3Y97_06895 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase C3Y97_06900 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C3Y97_06945 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C3Y97_06950 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3Y97_06955 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3Y97_06960 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C3Y97_06965 ENOG4105CZV ABC transporter C3Y97_06975 ENOG4105CJ1 ABC, transporter C3Y97_07015 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C3Y97_07020 ENOG4105EA8 2-Nitropropane dioxygenase C3Y97_07025 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C3Y97_07035 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C3Y97_07060 ENOG4105NQC Flavodoxin C3Y97_07105 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C3Y97_07135 ENOG4105CZN Potassium uptake protein C3Y97_07140 ENOG41063Y9 C3Y97_07145 ENOG4105KBJ sporulation protein ytfj C3Y97_07175 ENOG4105CM2 brancheD-chain amino acid aminotransferase C3Y97_07180 ENOG4105C7K acetolactate synthase C3Y97_07185 ENOG4108ZP8 Acetolactate synthase small subunit C3Y97_07190 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C3Y97_07205 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C3Y97_07210 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C3Y97_07220 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C3Y97_07225 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C3Y97_07230 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C3Y97_07235 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C3Y97_07240 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C3Y97_07245 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C3Y97_07250 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C3Y97_07255 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase C3Y97_07260 ENOG4107RVV histidinol phosphate phosphatase, hisj family C3Y97_07275 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C3Y97_07280 ENOG4105E0M Sulfatase C3Y97_07290 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C3Y97_07305 ENOG4107S4M Sulfate adenylate transferase C3Y97_07310 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C3Y97_07315 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C3Y97_07325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C3Y97_07330 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C3Y97_07335 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C3Y97_07345 ENOG4105C8J )-transporter C3Y97_07365 ENOG4105DFD Na H antiporter C3Y97_07385 ENOG4105ENE Histidine kinase C3Y97_07390 ENOG4105WH1 Two component transcriptional regulator luxr family C3Y97_07410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C3Y97_07435 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C3Y97_07460 ENOG4105CJ3 phosphate transporter C3Y97_07465 ENOG4107GRR phosphate transport regulator C3Y97_07470 ENOG4105BZ4 penicillin-binding protein C3Y97_07485 ENOG4105BZU Histidine kinase C3Y97_07490 ENOG4105I3N Conserved Protein C3Y97_07505 ENOG4105BZU Histidine kinase C3Y97_07510 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C3Y97_07535 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3Y97_07540 ENOG4105DZ1 carboxypeptidase C3Y97_07545 ENOG4108JIC nucleoside recognition domain protein C3Y97_07555 ENOG4105FE9 pseudouridine synthase C3Y97_07560 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3Y97_07565 ENOG4107TWT Cytochrome c biogenesis protein C3Y97_07570 ENOG4105CRE cytochrome C C3Y97_07575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_07580 ENOG4105BZU Histidine kinase C3Y97_07585 ENOG4108WBT adenosyltransferase C3Y97_07600 ENOG4108SAX Membrane C3Y97_07615 ENOG4105C9U ATP-dependent DNA helicase RecQ C3Y97_07620 ENOG4105I7S Abortive infection protein C3Y97_07630 ENOG4107RGJ metallophosphoesterase C3Y97_07635 ENOG4108XDN Transcriptional regulator C3Y97_07640 ENOG4108S6Z Negative regulator of genetic competence C3Y97_07665 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C3Y97_07670 ENOG4107RB3 L-asparaginase C3Y97_07690 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) C3Y97_07705 ENOG4105S2F C3Y97_07710 ENOG41065D1 C3Y97_07740 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C3Y97_07755 ENOG4105XXQ heptaprenyl diphosphate synthase component I C3Y97_07765 ENOG4105EAH synthase C3Y97_07770 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C3Y97_07775 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C3Y97_07780 ENOG4105D49 3-dehydroquinate synthase C3Y97_07790 ENOG41068YB TPR repeat-containing protein C3Y97_07805 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) C3Y97_07810 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C3Y97_07845 ENOG4108JYZ YitT family C3Y97_07855 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C3Y97_07860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C3Y97_07870 ENOG4105FJR Lmbe family C3Y97_07875 ENOG4105CPK Glycosyl transferase (Group 1 C3Y97_07900 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C3Y97_07915 ENOG4105DVT helicase C3Y97_07920 ENOG4105YAC C3Y97_07940 ENOG4105CSM endonuclease III C3Y97_07950 ENOG4105BZ4 penicillin-binding protein C3Y97_07995 ENOG4106F55 Protein of unknown function (DUF1273) C3Y97_08010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C3Y97_08020 ENOG4105DVT helicase C3Y97_08025 ENOG4105CTD carboxy-peptidase C3Y97_08035 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C3Y97_08040 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C3Y97_08045 ENOG4105C2W permease C3Y97_08050 ENOG4105DHF Membrane C3Y97_08060 ENOG410890F Dynamin family C3Y97_08070 ENOG4108W0I acetyltransferase C3Y97_08080 ENOG4105KHC sulfurtransferase C3Y97_08140 ENOG4105HTX biosynthesis protein C3Y97_08170 ENOG4105CPK Glycosyl transferase (Group 1 C3Y97_08185 ENOG4108SZE gCN5-related N-acetyltransferase C3Y97_08205 ENOG41081VK Ribonuclease C3Y97_08270 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3Y97_08280 ENOG4107RWR Sodium hydrogen exchanger C3Y97_08285 ENOG4105CN5 Metallo-Beta-Lactamase C3Y97_08290 ENOG4108Z5V transcriptional regulator, merr family C3Y97_08300 ENOG4105H67 Protein of unknown function (DUF421) C3Y97_08305 ENOG41080C8 DUF218 domain C3Y97_08340 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C3Y97_08350 ENOG4107R0U MotA TolQ exbB proton channel C3Y97_08355 ENOG4105ER2 Ompa motb domain protein C3Y97_08360 ENOG4107YTP response regulator receiver protein C3Y97_08365 ENOG4105CBS Chea signal transduction histidine kinase C3Y97_08370 ENOG4105DD5 Flagellar motor switch protein C3Y97_08385 ENOG4105BZU Histidine kinase C3Y97_08405 ENOG4105E1Q flagellar hook-associated protein C3Y97_08410 ENOG4105DTJ flagellar hook-associated protein C3Y97_08430 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C3Y97_08435 ENOG4108ZC9 flagellar basal-body rod protein flgc C3Y97_08440 ENOG41075Z6 flagellar hook-basal body complex protein fliE C3Y97_08445 ENOG4107U2N Flagellar M-ring protein C3Y97_08450 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C3Y97_08480 ENOG4105BZE flagellar hook protein, FlgE C3Y97_08495 ENOG4107R88 Chemotaxis protein (CheV) C3Y97_08510 ENOG4105I03 Flagellin C3Y97_08515 ENOG4105I03 Flagellin C3Y97_08520 ENOG4105E4C Lytic transglycosylase catalytic C3Y97_08530 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C3Y97_08535 ENOG4105DD5 Flagellar motor switch protein C3Y97_08545 ENOG4105CN7 Flagellar biosynthetic protein FliP C3Y97_08550 ENOG4105VS8 Flagellar biosynthetic protein fliq C3Y97_08560 ENOG4105D00 flagellar biosynthetic protein flhB C3Y97_08565 ENOG4105D7B Flagellar biosynthesis protein flha C3Y97_08570 ENOG4105FZW flagellar biosynthesis regulator FlhF C3Y97_08575 ENOG4105KTQ flagellar basal-body rod protein C3Y97_08580 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C3Y97_08615 ENOG4105KAC Antibiotic biosynthesis monooxygenase C3Y97_08640 ENOG4105DUM transcriptional regulator, lysR family C3Y97_08655 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component C3Y97_08690 ENOG4105CVJ phosphoglycerate mutase C3Y97_08700 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C3Y97_08720 ENOG4105CAQ asparagine synthetase C3Y97_08740 ENOG4105PGM cation diffusion facilitator family transporter C3Y97_08750 ENOG4105DRR Transcriptional regulator, GntR family C3Y97_08755 ENOG4108UZ3 Transporter C3Y97_08765 ENOG4105CKI cobalamin synthesis protein C3Y97_08770 ENOG4108PJD permease C3Y97_08785 ENOG4105DFD Na H antiporter C3Y97_08790 ENOG4105VUF Transcriptional regulator C3Y97_08800 ENOG4105C9Q fumarate hydratase class II C3Y97_08820 ENOG4107QJQ Mate efflux family protein C3Y97_08825 ENOG4105EC3 peptidase S51, dipeptidase E C3Y97_08845 ENOG4107QIV Cytochrome c biogenesis protein C3Y97_08850 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3Y97_08860 ENOG4107JM4 Tetratricopeptide repeat C3Y97_08875 ENOG4105BZC d-serine deaminase C3Y97_08880 ENOG4106BRA Membrane C3Y97_08920 ENOG4105CJ1 ABC, transporter C3Y97_08940 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C3Y97_08950 ENOG4108IJ0 Aspartate ammonia-lyase C3Y97_08955 ENOG4105C6K Malic enzyme C3Y97_09020 ENOG4105FVX C3Y97_09025 ENOG4105E09 nadh pyrophosphatase C3Y97_09045 ENOG4105CSR polyphosphate kinase 2 C3Y97_09050 ENOG4105U3E Transcriptional regulator C3Y97_09065 ENOG4105DXI Major Facilitator superfamily C3Y97_09080 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C3Y97_09085 ENOG4105EU0 Major facilitator Superfamily C3Y97_09090 ENOG4105C6T cysteine synthase C3Y97_09110 ENOG4105C8J )-transporter C3Y97_09120 ENOG4105X5K response regulator receiver protein C3Y97_09125 ENOG4105H67 Protein of unknown function (DUF421) C3Y97_09155 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C3Y97_09160 ENOG4105CHR reductase C3Y97_09165 ENOG4105CM2 brancheD-chain amino acid aminotransferase C3Y97_09170 ENOG4105C7K acetolactate synthase C3Y97_09180 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C3Y97_09185 ENOG4105C01 Dihydroxy-acid dehydratase C3Y97_09190 ENOG4105C7B Threonine dehydratase C3Y97_09215 ENOG4105C6X Major Facilitator C3Y97_09220 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C3Y97_09230 ENOG4105DY9 regulatoR C3Y97_09235 ENOG4105CYC Transferase C3Y97_09260 ENOG41068WN C3Y97_09265 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C3Y97_09270 ENOG4105C72 UPF0176 protein C3Y97_09280 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C3Y97_09285 ENOG4105C0X amino acid C3Y97_09325 ENOG410849A acetyltransferase, (GNAT) family C3Y97_09335 ENOG4105K8R UPF0145 protein C3Y97_09350 ENOG4107RHR regulatoR C3Y97_09360 ENOG4105D9N nucleoside C3Y97_09365 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C3Y97_09395 ENOG410811B TRANSCRIPTIONal C3Y97_09410 ENOG4107RAQ aminopeptidase C3Y97_09420 ENOG4107R16 Multicopper oxidase C3Y97_09465 ENOG4108T5E Copper resistance protein C3Y97_09470 ENOG4105KTB nuclear export factor GLE1 C3Y97_09475 ENOG4107RT3 EamA-like transporter family C3Y97_09480 ENOG4105GZI Transcriptional regulator C3Y97_09485 ENOG4108Z40 Transcriptional regulator C3Y97_09490 ENOG4107ZXU DSBA oxidoreductase C3Y97_09495 ENOG4108TVJ Nitroreductase C3Y97_09505 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3Y97_09510 ENOG4106F5Q Membrane C3Y97_09515 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3Y97_09530 ENOG4105CKI cobalamin synthesis protein C3Y97_09540 ENOG4105C0Z ABC transporter C3Y97_09545 ENOG4108IV0 ABC, transporter C3Y97_09550 ENOG4105C32 Amino acid ABC transporter (Permease) C3Y97_09560 ENOG4105SKE transcriptional Regulator LysR family C3Y97_09570 ENOG4105MDS 4-oxalocrotonate tautomerase C3Y97_09590 ENOG4105C4M (Ubiquinol oxidase) subunit I C3Y97_09595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C3Y97_09600 ENOG4108JJ9 ABC, transporter C3Y97_09605 ENOG4108JJ8 (ABC) transporter C3Y97_09615 ENOG4105K64 Glycosyl transferase, family 2 C3Y97_09625 ENOG4108UT6 Transferase hexapeptide repeat containing protein C3Y97_09680 ENOG4105BZ1 (ABC) transporter C3Y97_09685 ENOG4105EFI regulatoR C3Y97_09690 ENOG4105BZU Histidine kinase C3Y97_09700 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C3Y97_09705 ENOG4108ZJ4 polysaccharide deacetylase C3Y97_09725 ENOG4105D6E homoserine dehydrogenase C3Y97_09750 ENOG4108KGH TRANSCRIPTIONal C3Y97_09760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3Y97_09765 ENOG4105BZU Histidine kinase C3Y97_09770 ENOG4107VMI polysaccharide deacetylase C3Y97_09780 ENOG4105KT7 mgtC SapB transporter C3Y97_09795 ENOG4105VRR gCN5-related N-acetyltransferase C3Y97_09805 ENOG4105DUU IucA IucC family protein C3Y97_09810 ENOG4105CEY Amp-dependent synthetase and ligase C3Y97_09825 ENOG4108WBH protein TIM barrel C3Y97_09830 ENOG4105YWU small acid-soluble spore protein C3Y97_09840 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C3Y97_09845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3Y97_09895 ENOG4105KRN Transcriptional regulator, abrb family C3Y97_09905 ENOG4105YVS arsR family transcriptional regulator C3Y97_09910 ENOG4105CPC Aldo Keto reductase C3Y97_09915 ENOG4107XZQ multidrug resistance protein C3Y97_09925 ENOG4105KAF membrAne C3Y97_09950 ENOG4105C8Q Methyl-accepting chemotaxis C3Y97_09970 ENOG4108K88 Membrane C3Y97_09975 ENOG4108WPJ Ferritin-like domain C3Y97_09990 ENOG4105DEN Luciferase family C3Y97_10005 ENOG4105VMI -acetyltransferase C3Y97_10010 ENOG4107QM2 Aldo Keto reductase C3Y97_10015 ENOG4105CKI cobalamin synthesis protein C3Y97_10025 ENOG4105DSE periplasmic solute binding protein C3Y97_10030 ENOG4105K4T epimerase C3Y97_10040 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3Y97_10085 ENOG4107T5V SNARE associated Golgi C3Y97_10110 ENOG4108PJD permease C3Y97_10120 ENOG4108S4H thioesterase Superfamily protein C3Y97_10130 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3Y97_10150 ENOG4105SXS Protein of unknown function (DUF456) C3Y97_10155 ENOG4105C37 (CBS) domain C3Y97_10175 ENOG4108Z7R Chaperone CsaA C3Y97_10195 ENOG4108ZRV stage ii sporulation protein p C3Y97_10205 ENOG4108VXD carboxy-peptidase C3Y97_10215 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3Y97_10235 ENOG4108ZRV stage ii sporulation protein p C3Y97_10245 ENOG4108X4Q Hydrolase C3Y97_10260 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C3Y97_10280 ENOG41087PP glycosyltransferase MGT family C3Y97_10285 ENOG4108JYZ YitT family C3Y97_10290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3Y97_10340 ENOG4106PAW secretion accessory protein EsaA YueB C3Y97_10350 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) C3Y97_10355 ENOG4108MGT Required for secretion of EsxA and EsxB C3Y97_10415 ENOG4105KBJ sporulation protein ytfj C3Y97_10440 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C3Y97_10460 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C3Y97_10465 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C3Y97_10475 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C3Y97_10480 ENOG4105EMN RNA polymerase sigma factor C3Y97_10490 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C3Y97_10500 ENOG4105CNW domain protein C3Y97_10510 ENOG4108V06 Glutathione peroxidase C3Y97_10525 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3Y97_10535 ENOG4108IUE nitrate reductase beta subunit C3Y97_10540 ENOG4105R3A Nitrate reductase C3Y97_10550 ENOG4107V6Q Cyclic nucleotide-binding domain C3Y97_10555 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3Y97_10560 ENOG4105D06 uba thif-type nad fad binding protein C3Y97_10565 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3Y97_10570 ENOG4108ZAF Molybdopterin C3Y97_10605 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C3Y97_10610 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C3Y97_10615 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C3Y97_10620 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C3Y97_10625 ENOG4108IFG nitrite reductase, (NAD(P)H) C3Y97_10630 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) C3Y97_10665 ENOG4105MCT stage V sporulation protein S C3Y97_10710 ENOG4105C5H ABC transporter C3Y97_10785 ENOG4107YX5 Pfam:DUF548 C3Y97_10790 ENOG4105C75 arginyL-tRNA synthetase C3Y97_10815 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C3Y97_10845 ENOG4105C5S asparaginyl-tRNA synthetase C3Y97_10850 ENOG4105C8J )-transporter C3Y97_10870 ENOG4107XGZ Hydrolase C3Y97_10875 ENOG4105CY2 Citrate transporter C3Y97_10895 ENOG4105KD7 acetyltransferase C3Y97_10905 ENOG4105VMP Transcriptional regulator C3Y97_10910 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C3Y97_10935 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 C3Y97_10950 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) C3Y97_10955 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C3Y97_10965 ENOG4107RVG penicillin-binding protein C3Y97_10970 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C3Y97_10975 ENOG4105E9Q Acyl-transferase C3Y97_10980 ENOG4108UT2 hemolysin iii C3Y97_10990 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C3Y97_11000 ENOG4108RCR degv family C3Y97_11010 ENOG4108KF3 Electron transport protein SCO1 SenC C3Y97_11015 ENOG4107Y70 Heat shock protein C3Y97_11020 ENOG4105CAQ asparagine synthetase C3Y97_11035 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C3Y97_11040 ENOG4108MES Periplasmic binding protein C3Y97_11045 ENOG4105F0I Aminotransferase C3Y97_11080 ENOG4105D8X mechanosensitive ion channel C3Y97_11085 ENOG4105BZU Histidine kinase C3Y97_11090 ENOG4105WH1 Two component transcriptional regulator luxr family C3Y97_11095 ENOG4106KNT transcriptional regulator C3Y97_11100 ENOG4107ZY0 Phenazine biosynthesis-like protein C3Y97_11120 ENOG4105CMG Carbohydrate kinase C3Y97_11125 ENOG4105C6Z Gluconate C3Y97_11135 ENOG4108YV3 Protein of unknown function (DUF2711) C3Y97_11165 ENOG4108IJ8 ABC transporter C3Y97_11170 ENOG4105E90 ABC transporter C3Y97_11205 ENOG4105C37 (CBS) domain C3Y97_11230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3Y97_11245 ENOG4107S4Y M20 DapE family protein YgeY C3Y97_11250 ENOG4108TSC N-acetyltransferase C3Y97_11255 ENOG4108JUB Transcriptional regulator C3Y97_11260 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C3Y97_11305 ENOG410841Q phosphoesterase PA-phosphatase related protein C3Y97_11315 ENOG4105SZ6 Thioredoxin C3Y97_11320 ENOG4105KNA -acetyltransferase C3Y97_11375 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3Y97_11430 ENOG4105BZ4 penicillin-binding protein C3Y97_11440 ENOG4105CZM Major Facilitator C3Y97_11445 ENOG4105W8X HesB YadR YfhF-family protein C3Y97_11455 ENOG4105DXD 2-methylcitrate dehydratase C3Y97_11460 ENOG4105CR4 methylisocitrate lyase C3Y97_11465 ENOG4105C1G acyl-Coa dehydrogenase C3Y97_11470 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C3Y97_11480 ENOG4105N14 lysine exporter protein LysE YggA C3Y97_11485 ENOG4105E39 Enoyl-CoA hydratase C3Y97_11500 ENOG4107RFY SbcCD D subunit C3Y97_11505 ENOG4105EYH Exonuclease C3Y97_11535 ENOG4105FCD Major Facilitator C3Y97_11545 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C3Y97_11550 ENOG4105E4F Isochorismate synthase C3Y97_11555 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C3Y97_11560 ENOG4105WQI isochorismatase C3Y97_11565 ENOG4105CEY Amp-dependent synthetase and ligase C3Y97_11570 ENOG4105WQT MbtH domain protein C3Y97_11575 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3Y97_11590 ENOG4105K70 DNA-binding protein C3Y97_11610 ENOG4105BZG amino acid carrier protein C3Y97_11630 ENOG4105FE9 pseudouridine synthase C3Y97_11635 ENOG4105C22 threonyL-tRNA synthetase C3Y97_11640 ENOG4105C19 ABC transporter C3Y97_11685 ENOG41081I9 integral membrane protein C3Y97_11695 ENOG4108Y4K DNA-binding transcriptional activator C3Y97_11720 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C3Y97_11730 ENOG4105EYF MMPL domain protein C3Y97_11770 ENOG4105WCN acetyltransferase C3Y97_11795 ENOG4105C1Q protoporphyrinogen oxidase C3Y97_11805 ENOG41068WN C3Y97_11835 ENOG4107V2S Transcriptional regulator C3Y97_11840 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C3Y97_11860 ENOG4105DND Transcriptional regulator C3Y97_11865 ENOG4108RPX mosc domain containing protein C3Y97_11880 ENOG4105BZ1 (ABC) transporter C3Y97_11885 ENOG4105BZ1 (ABC) transporter C3Y97_11920 ENOG4108JCI Transcriptional regulator C3Y97_11950 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) C3Y97_11955 ENOG4108KPJ rna polymerase sigma factor C3Y97_11985 ENOG4105F32 YngK protein C3Y97_12005 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) C3Y97_12010 ENOG4105RD7 BadF BadG BcrA BcrD C3Y97_12015 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C3Y97_12020 ENOG4107STF Involved in phosphonate degradation (By similarity) C3Y97_12025 ENOG4105C7B Threonine dehydratase C3Y97_12030 ENOG4108INS Transcriptional regulator C3Y97_12055 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C3Y97_12065 ENOG4105C1J atp-dependent rna helicase C3Y97_12075 ENOG4108RZE Tetr family transcriptional regulator C3Y97_12210 ENOG41088CC tellurite resistance protein tehB C3Y97_12220 ENOG4108I0C methyltransferase C3Y97_12225 ENOG4107RA9 decarboxylase C3Y97_12230 ENOG4105K56 Transcriptional regulator C3Y97_12235 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C3Y97_12265 ENOG4105CIN aminoacyl-histidine dipeptidase C3Y97_12290 ENOG4105KRN Transcriptional regulator, abrb family C3Y97_12305 ENOG4105EJ9 Membrane C3Y97_12310 ENOG4105EQK -acetyltransferase C3Y97_12445 ENOG4105ED2 Beta-lactamase C3Y97_12480 ENOG4105FQP Beta-lactamase C3Y97_12485 ENOG4107RVG penicillin-binding protein C3Y97_12500 ENOG4107RF6 penicillin-binding protein C3Y97_12505 ENOG4107RF6 penicillin-binding protein C3Y97_12515 ENOG4105DIN metallophosphoesterase C3Y97_12525 ENOG4105CJ1 ABC, transporter C3Y97_12535 ENOG4107Z3H Transcriptional regulator, TetR family C3Y97_12550 ENOG4105C1G acyl-Coa dehydrogenase C3Y97_12555 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C3Y97_12560 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C3Y97_12565 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C3Y97_12570 ENOG4105E39 Enoyl-CoA hydratase C3Y97_12575 ENOG4107QX3 carboxylase C3Y97_12580 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3Y97_12605 ENOG4105DBI uridine monophosphokinase C3Y97_12630 ENOG4105DZ1 carboxypeptidase C3Y97_12645 ENOG4105T9C HD domain C3Y97_12665 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C3Y97_12685 ENOG41075H3 AraC family transcriptional regulator C3Y97_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C3Y97_12720 ENOG4107Y80 Major Facilitator superfamily C3Y97_12725 ENOG4105CHR reductase C3Y97_12730 ENOG4105KVH Transcriptional regulator C3Y97_12735 ENOG41089UC methyltransferase, type 11 C3Y97_12785 ENOG4105EFA 4-hydroxyphenylacetate C3Y97_12800 ENOG4105CPQ Dehydrogenase C3Y97_12810 ENOG410900G Protein of unknown function (DUF421) C3Y97_12815 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C3Y97_12825 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C3Y97_12835 ENOG4105DK7 lysyl-tRNA synthetase C3Y97_12845 ENOG4108VQT Alpha beta hydrolase fold protein C3Y97_12885 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C3Y97_12920 ENOG4105D6E homoserine dehydrogenase C3Y97_12930 ENOG4105CPF Cell wall formation (By similarity) C3Y97_12935 ENOG4105ETU transcriptional activator (TenA C3Y97_13035 ENOG410667J hydrolase C3Y97_13040 ENOG4105BZU Histidine kinase C3Y97_13045 ENOG4107RF6 penicillin-binding protein C3Y97_13070 ENOG4108JJB ABC transporter C3Y97_13085 ENOG4108HGU Histidine kinase C3Y97_13175 ENOG4105CB2 alcohol dehydrogenase C3Y97_13180 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C3Y97_13185 ENOG4105CJN penicillin-binding protein C3Y97_13235 ENOG4107SFI Major Facilitator superfamily C3Y97_13240 ENOG4108Z5V transcriptional regulator, merr family C3Y97_13265 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C3Y97_13290 ENOG4107Y9U Membrane C3Y97_13335 ENOG4105FCD Major Facilitator C3Y97_13350 ENOG4105E09 nadh pyrophosphatase C3Y97_13355 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C3Y97_13375 ENOG4105KME endoribonuclease L-psp C3Y97_13380 ENOG4108XI2 Domain of unknown function (DUF1963) C3Y97_13405 ENOG4108NRW Phospholipase, patatin family C3Y97_13410 ENOG4105KWG Pfam:DUF1696 C3Y97_13420 ENOG4108YYS metal-dependent hydrolase (By similarity) C3Y97_13435 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C3Y97_13445 ENOG4105PKS Excinuclease abc c subunit domain protein C3Y97_13475 ENOG4105CJ1 ABC, transporter C3Y97_13495 ENOG4107VFR oxidoreductase C3Y97_13530 ENOG4105U0R haloacid dehalogenase-like hydrolase C3Y97_13535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_13540 ENOG4105BZU Histidine kinase C3Y97_13560 ENOG4107WD8 ABC transporter, permease C3Y97_13575 ENOG4105DY8 decarboxylase C3Y97_13590 ENOG4108IUM Glycogen debranching enzyme C3Y97_13600 ENOG4105CGH 5'-nucleotidase C3Y97_13620 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C3Y97_13625 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C3Y97_13630 ENOG4105FDR Membrane C3Y97_13640 ENOG4105CIS alcohol dehydrogenase C3Y97_13645 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) C3Y97_13690 ENOG4105MSI germination protein ypeb C3Y97_13720 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) C3Y97_13725 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) C3Y97_13730 ENOG4107Z3H Transcriptional regulator, TetR family C3Y97_13755 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C3Y97_13775 ENOG4105E98 transcriptional regulator DeoR family C3Y97_13790 ENOG41062ES Transcriptional regulator C3Y97_13810 ENOG4107QKR Dehydrogenase C3Y97_13820 ENOG4107RUY (E1 component), alpha subunit C3Y97_13830 ENOG4105E1F short-chain dehydrogenase reductase C3Y97_13860 ENOG4107SQ8 Glycine betaine C3Y97_13865 ENOG4108IJ7 Glycine betaine C3Y97_13890 ENOG4105E66 phosphoriboisomerase A C3Y97_13895 ENOG41082BV acetyltransferase C3Y97_13900 ENOG4108M1A Chitin-binding protein C3Y97_13930 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3Y97_13935 ENOG4105MSB protein, conserved in bacteria C3Y97_13960 ENOG4108Z7F N-acetyltransferase C3Y97_13980 ENOG4105KEG ribosomal-protein-alanine acetyltransferase C3Y97_13985 ENOG4105EEM helicase C3Y97_14000 ENOG4105C9U ATP-dependent DNA helicase RecQ C3Y97_14055 ENOG4108M1A Chitin-binding protein C3Y97_14075 ENOG4105BZG amino acid carrier protein C3Y97_14080 ENOG4105C26 Dehydrogenase C3Y97_14085 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C3Y97_14090 ENOG4105CTU Proline racemase C3Y97_14095 ENOG4105CTU Proline racemase C3Y97_14100 ENOG41080HI glycine oxidase C3Y97_14110 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein C3Y97_14145 ENOG4105DCI Phosphohydrolase C3Y97_14150 ENOG4107T5V SNARE associated Golgi C3Y97_14160 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C3Y97_14180 ENOG4105DTQ mandelate racemase muconate lactonizing C3Y97_14195 ENOG4107SET aldo keto reductase C3Y97_14230 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) C3Y97_14235 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3Y97_14240 ENOG4105BZU Histidine kinase C3Y97_14245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_14265 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 C3Y97_14280 ENOG4105DPN Oligoendopeptidase f C3Y97_14285 ENOG4105EPR degv family C3Y97_14350 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C3Y97_14355 ENOG4106K7D Major facilitator family transporter C3Y97_14375 ENOG4107BMA Transglycosylase associated protein C3Y97_14390 ENOG41089UC methyltransferase, type 11 C3Y97_14430 ENOG4105CHM Aminotransferase C3Y97_14460 ENOG4105DVE abc transporter atp-binding protein C3Y97_14515 ENOG4105C02 permease C3Y97_14530 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C3Y97_14535 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C3Y97_14540 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C3Y97_14545 ENOG4105D7T ABC transporter C3Y97_14580 ENOG4108AQF aminoglycoside N(3)-acetyltransferase C3Y97_14620 ENOG4107VC0 DNA alkylation repair enzyme C3Y97_14625 ENOG4105C6T cysteine synthase C3Y97_14630 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C3Y97_14640 ENOG4107VMI polysaccharide deacetylase C3Y97_14650 ENOG4108ZCF integral membrane protein C3Y97_14655 ENOG4105E0M Sulfatase C3Y97_14660 ENOG4105C5H ABC transporter C3Y97_14665 ENOG4105EYF MMPL domain protein C3Y97_14670 ENOG41082JN Transcriptional regulator C3Y97_14690 ENOG4105CIH Imidazole acetol-phosphate transaminase C3Y97_14695 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C3Y97_14705 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C3Y97_14755 ENOG41069ER domain protein C3Y97_14765 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C3Y97_14795 ENOG4105D4B ABC, transporter C3Y97_14800 ENOG4105F5R ABC transporter C3Y97_14805 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane C3Y97_14815 ENOG4105DKT Transcriptional regulator C3Y97_14820 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) C3Y97_14830 ENOG41061GT Aldolase C3Y97_14840 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C3Y97_14880 ENOG4105II7 pyrroline-5-carboxylate reductase C3Y97_14890 ENOG4107258 Transcriptional regulator C3Y97_14915 ENOG4105ECK Fatty Acid Desaturase C3Y97_14925 ENOG4107RBI VanW family C3Y97_14930 ENOG4105G6Z alkaline phosphatase C3Y97_14940 ENOG4105VMP Transcriptional regulator C3Y97_14960 ENOG41068WN C3Y97_14990 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3Y97_15015 ENOG4105CKK Glycosyl transferase, family 2 C3Y97_15045 ENOG4105C8Y Acetylornithine aminotransferase C3Y97_15095 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3Y97_15145 ENOG4108IBT Inherit from COG: transposase C3Y97_15165 ENOG4108TVJ Nitroreductase C3Y97_15170 ENOG4105FS7 Transcriptional regulator C3Y97_15190 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C3Y97_15205 ENOG4105CMR udp-glucose 4-epimerase C3Y97_15215 ENOG4108DMH HTH_ARAC C3Y97_15220 ENOG4108XET gCN5-related N-acetyltransferase C3Y97_15235 ENOG4108PCN EamA-like transporter family C3Y97_15255 ENOG4107XJU UPF0178 protein C3Y97_15310 ENOG410635A Membrane C3Y97_15320 ENOG4108IQI permease C3Y97_15330 ENOG4105F1N DNA alkylation repair C3Y97_15340 ENOG4105BZU Histidine kinase C3Y97_15345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_15355 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3Y97_15390 ENOG4107RF6 penicillin-binding protein C3Y97_15395 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C3Y97_15415 ENOG4105E7W lamb ycsf family protein C3Y97_15425 ENOG4105P4J Allophanate hydrolase, subunit 1 C3Y97_15430 ENOG4107258 Transcriptional regulator C3Y97_15440 ENOG4106N3A copper homeostasis protein cutc C3Y97_15445 ENOG4108ZHR arsR family transcriptional regulator C3Y97_15455 ENOG4105FDT acyl-CoA dehydrogenase C3Y97_15470 ENOG4105DWD nucleoside recognition domain protein C3Y97_15515 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C3Y97_15580 ENOG4105E2A Dehydrogenase C3Y97_15590 ENOG4108IJ0 Aspartate ammonia-lyase C3Y97_15595 ENOG4105HDK L-asparaginase C3Y97_15600 ENOG4108IMY Transcriptional regulator C3Y97_15625 ENOG4108B31 Spore germination protein C3Y97_15635 ENOG4105BZU Histidine kinase C3Y97_15660 ENOG41075H3 AraC family transcriptional regulator C3Y97_15675 ENOG4105YWU small acid-soluble spore protein C3Y97_15680 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C3Y97_15685 ENOG4105CUB amino acid C3Y97_15690 ENOG4105II7 pyrroline-5-carboxylate reductase C3Y97_15695 ENOG4108NHD germination protein C3Y97_15700 ENOG4108Q8B Spore germination protein C3Y97_15740 ENOG4106A3M Cytochrome p-450 C3Y97_15755 ENOG4105CGH 5'-nucleotidase C3Y97_15765 ENOG4105CHJ isochorismatase hydrolase C3Y97_15790 ENOG41090MY MarR family Transcriptional regulator C3Y97_15815 ENOG4105F6J Alpha beta hydrolase fold C3Y97_15830 ENOG4108606 TspO/MBR family C3Y97_15835 ENOG4105CVP deoxyribo-dipyrimidine photolyase C3Y97_15860 ENOG4108TWJ NADH dehydrogenase subunit 5 C3Y97_15865 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C3Y97_15880 ENOG4105E1K spore germination protein C3Y97_15885 ENOG4107VMI polysaccharide deacetylase C3Y97_15890 ENOG4105KY5 gCN5-related N-acetyltransferase C3Y97_15895 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C3Y97_15905 ENOG4105Z7P Acetyltransferase (GNAT) family C3Y97_15915 ENOG4105D6J arsenicaL-resistance protein C3Y97_15920 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase C3Y97_15925 ENOG41085FC arsR family transcriptional regulator C3Y97_15940 ENOG4105NAE bifunctional deaminase-reductase domain protein C3Y97_15945 ENOG4107P5I polyketide synthase C3Y97_15950 ENOG4108IG5 Transcriptional regulator C3Y97_15965 ENOG4105EQ0 Major Facilitator superfamily C3Y97_15970 ENOG4108JGH Tetr family transcriptional regulator C3Y97_15980 ENOG4105XRQ Xanthine dehydrogenase accessory factor C3Y97_15995 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C3Y97_16025 ENOG4105CHR reductase C3Y97_16030 ENOG4108YXU transcriptional regulator AsnC family C3Y97_16105 ENOG4105C44 Serine transporter C3Y97_16110 ENOG4105DUM transcriptional regulator, lysR family C3Y97_16115 ENOG4105DWP Membrane C3Y97_16125 ENOG4105N0V mono-oxygenase ydhR C3Y97_16170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_16175 ENOG41062D9 Histidine kinase C3Y97_16225 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C3Y97_16230 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3Y97_16255 ENOG4105K6H D-cysteine desulfhydrase C3Y97_16265 ENOG4105E0Y RtcB Protein C3Y97_16275 ENOG4105JQZ Methyltransferase C3Y97_16290 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) C3Y97_16310 ENOG4105BZU Histidine kinase C3Y97_16320 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C3Y97_16330 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C3Y97_16375 ENOG4105C44 Serine transporter C3Y97_16400 ENOG4108JPW Aminotransferase C3Y97_16415 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) C3Y97_16425 ENOG4105DVH amino acid C3Y97_16445 ENOG4108JQ1 Dehydrogenase C3Y97_16450 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C3Y97_16465 ENOG41082W1 Cupin 2, conserved barrel domain protein C3Y97_16475 ENOG410874W AraC family transcriptional regulator C3Y97_16500 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C3Y97_16620 ENOG4108VXD carboxy-peptidase C3Y97_16625 ENOG4105PNM synthesis protein C3Y97_16635 ENOG4108ISG Major Facilitator C3Y97_16650 ENOG4107MII Sugar-specific transcriptional regulator TrmB C3Y97_16655 ENOG4105CZM Major Facilitator C3Y97_16670 ENOG4105DA5 (ABC) transporter C3Y97_16675 ENOG41069JR C3Y97_16690 ENOG4105CRW Short chain fatty acid transporter C3Y97_16700 ENOG4105DYS nad(p)h dehydrogenase (quinone) C3Y97_16760 ENOG4108K8S endonuclease I C3Y97_16785 ENOG4108Z66 YbaK ebsC protein C3Y97_16790 ENOG4105CUT histidyl-tRNA synthetase C3Y97_16805 ENOG4105KVH Transcriptional regulator C3Y97_16810 ENOG4108RCM Nitroreductase C3Y97_16845 ENOG4108PSK reductase C3Y97_16920 ENOG4105C31 Tryptophanyl-tRNA synthetase C3Y97_16925 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C3Y97_16955 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) C3Y97_16965 ENOG4105EV4 Multidrug resistance protein mdtH C3Y97_16995 ENOG4105C37 (CBS) domain C3Y97_17010 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C3Y97_17015 ENOG4105FAW cDP-glucose 4,6-dehydratase C3Y97_17050 ENOG4105DDN Pentapeptide repeat-containing protein C3Y97_17055 ENOG4105XDF Protein of unknown function (DUF1272) C3Y97_17060 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C3Y97_17065 ENOG4105CMG Carbohydrate kinase C3Y97_17070 ENOG4105C6Z Gluconate C3Y97_17085 ENOG4105CV1 Transketolase (EC 2.2.1.1) C3Y97_17090 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C3Y97_17105 ENOG4105CIS alcohol dehydrogenase C3Y97_17110 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone C3Y97_17130 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C3Y97_17145 ENOG4105C8Q Methyl-accepting chemotaxis C3Y97_17150 ENOG4108UX3 '-nucleotidase C3Y97_17155 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C3Y97_17160 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C3Y97_17165 ENOG4105KVH Transcriptional regulator C3Y97_17185 ENOG4105CV8 reductase C3Y97_17190 ENOG4105F27 Major Facilitator C3Y97_17200 ENOG41090KN UPF0303 protein C3Y97_17220 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C3Y97_17225 ENOG4105CHH sulfate transporter C3Y97_17240 ENOG4105C44 Serine transporter C3Y97_17275 ENOG4105KVH Transcriptional regulator C3Y97_17280 ENOG4108TZY GntR Family Transcriptional Regulator C3Y97_17285 ENOG4105D9R oxidoreductase C3Y97_17290 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C3Y97_17295 ENOG4105KVH Transcriptional regulator C3Y97_17300 ENOG4105KVH Transcriptional regulator C3Y97_17345 ENOG4105JAB phenazine biosynthesis protein, phzf family C3Y97_17355 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C3Y97_17360 ENOG4105KVH Transcriptional regulator C3Y97_17385 ENOG4108ZJ4 polysaccharide deacetylase C3Y97_17465 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) C3Y97_17480 ENOG4107YXZ hydrolase, family 25 C3Y97_17510 ENOG4105H3G oxidoreductase C3Y97_17585 ENOG4108TN2 lmbE family C3Y97_17595 ENOG4107R3E Citrate transporter C3Y97_17610 ENOG4108MES Periplasmic binding protein C3Y97_17615 ENOG4105EHG Permease protein C3Y97_17620 ENOG4105DQ5 transport system permease protein C3Y97_17625 ENOG4105NX3 Membrane C3Y97_17645 ENOG41068WN C3Y97_17650 ENOG4107CUJ Protein of unknown function (DUF2690) C3Y97_17660 ENOG4107V2S Transcriptional regulator C3Y97_17680 ENOG4105C98 muts2 protein C3Y97_17685 ENOG4105E5K Alpha-amylase C3Y97_17690 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C3Y97_17695 ENOG4105DPN Oligoendopeptidase f C3Y97_17730 ENOG4108A04 Beta-lactamase C3Y97_17755 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C3Y97_17765 ENOG41082BM Transcriptional regulator, arsr family C3Y97_17770 ENOG4105CIS alcohol dehydrogenase C3Y97_17810 ENOG4105CQB FAD linked oxidase domain protein C3Y97_17835 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C3Y97_17850 ENOG4107TPS domain protein C3Y97_17855 ENOG4105CEP NADH dehydrogenase C3Y97_17865 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C3Y97_17875 ENOG4108IAJ Nad-dependent epimerase dehydratase C3Y97_17880 ENOG4105FAW cDP-glucose 4,6-dehydratase C3Y97_18075 ENOG4105DR5 peptidase C3Y97_18220 ENOG4105GR3 Histidine kinase C3Y97_18225 ENOG4105BZU Histidine kinase C3Y97_18235 ENOG41069ER domain protein C3Y97_18285 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C3Y97_18305 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C3Y97_18350 ENOG4105BZU Histidine kinase C3Y97_18355 ENOG4105C5H ABC transporter C3Y97_18380 ENOG4105BZU Histidine kinase C3Y97_18390 ENOG4105KT7 mgtC SapB transporter C3Y97_18400 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C3Y97_18405 ENOG41073R8 VanW family C3Y97_18415 ENOG4108R1P C3Y97_18435 ENOG4105VEQ Cold shock protein C3Y97_18475 ENOG410904N short-chain dehydrogenase reductase C3Y97_18485 ENOG4106IQC argininosuccinate lyase C3Y97_18500 ENOG4108IA2 Sodium pantothenate symporter C3Y97_18510 ENOG4105C26 Dehydrogenase C3Y97_18515 ENOG4105CHR reductase C3Y97_18525 ENOG4105EWU Squalene--hopene cyclase C3Y97_18535 ENOG4105FR1 rard protein C3Y97_18540 ENOG410696E Membrane C3Y97_18555 ENOG4105D1F ATP-binding protein C3Y97_18565 ENOG4108ZAF Molybdopterin C3Y97_18570 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3Y97_18575 ENOG4105D06 uba thif-type nad fad binding protein C3Y97_18580 ENOG4105TMB Formate nitrite transporter C3Y97_18595 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C3Y97_18600 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C3Y97_18610 ENOG4108JB9 formate dehydrogenase C3Y97_18615 ENOG4105E1K spore germination protein C3Y97_18630 ENOG4105CUB amino acid C3Y97_18685 ENOG4108KGH TRANSCRIPTIONal C3Y97_18695 ENOG4105EMN RNA polymerase sigma factor C3Y97_18705 ENOG4105CIG ABC transporter C3Y97_18725 ENOG4105D9R oxidoreductase C3Y97_18735 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3Y97_18745 ENOG4105K4P CoA-binding domain protein C3Y97_18750 ENOG4105C0H protease C3Y97_18755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_18765 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C3Y97_18770 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C3Y97_18805 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C3Y97_18810 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3Y97_18825 ENOG4105BZ1 (ABC) transporter C3Y97_18830 ENOG4108I0Z Aconitate hydratase C3Y97_18860 ENOG4105E5W Transporter C3Y97_18870 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C3Y97_18895 ENOG4107ZYJ bioY protein C3Y97_18900 ENOG4105CEY Amp-dependent synthetase and ligase C3Y97_18945 ENOG4107AYK membrAne C3Y97_18960 ENOG4105BZU Histidine kinase C3Y97_18965 ENOG4105FBA Phospholipase Carboxylesterase C3Y97_18970 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C3Y97_18975 ENOG4105CK7 Sodium proline symporter C3Y97_18980 ENOG4105CBC glutamate synthase C3Y97_18985 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C3Y97_18990 ENOG4108VJ1 Transcriptional regulator (CarD family C3Y97_18995 ENOG4108903 Formimidoylglutamase C3Y97_19005 ENOG4105CGP Urocanate hydratase C3Y97_19060 ENOG4107QIV Cytochrome c biogenesis protein C3Y97_19075 ENOG4105CH2 amidohydrolase C3Y97_19085 ENOG4105CJ1 ABC, transporter C3Y97_19100 ENOG4107RSM transcriptional regulator C3Y97_19105 ENOG4105VAW lrga family C3Y97_19110 ENOG41067MG lrgb family C3Y97_19150 ENOG4105BZ1 (ABC) transporter C3Y97_19155 ENOG4105BZ1 (ABC) transporter C3Y97_19190 ENOG4108HW3 (ABC) transporter C3Y97_19195 ENOG4105CGH 5'-nucleotidase C3Y97_19205 ENOG4108SVB resolvase C3Y97_19225 ENOG4105K7K Transcriptional regulator C3Y97_19230 ENOG4105C5F glutamine synthetase C3Y97_19235 ENOG4105KV4 Transcriptional regulator C3Y97_19240 ENOG4105CXI aluminum resistance protein C3Y97_19245 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C3Y97_19250 ENOG4105EN6 Membrane C3Y97_19255 ENOG4106F1P AAA ATPase, central domain protein C3Y97_19285 ENOG41069ER domain protein C3Y97_19295 ENOG4105DM4 PTS System C3Y97_19300 ENOG4105DE4 1-phosphofructokinase C3Y97_19305 ENOG4105E98 transcriptional regulator DeoR family C3Y97_19310 ENOG4107QW4 alcohol dehydrogenase C3Y97_19315 ENOG4108SJC Membrane C3Y97_19330 ENOG4105C85 amino acid C3Y97_19350 ENOG4105TMB Formate nitrite transporter C3Y97_19355 ENOG4105K70 DNA-binding protein C3Y97_19365 ENOG4105C59 p-type ATPase C3Y97_19370 ENOG410681U heavy metal transport detoxification protein C3Y97_19375 ENOG4105VPX protein, conserved in bacteria C3Y97_19385 ENOG4105NIV Esterase C3Y97_19390 ENOG4105E0A ABC, transporter C3Y97_19415 ENOG4105CGK Exodeoxyribonuclease III C3Y97_19425 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3Y97_19430 ENOG4105D03 DNA-3-methyladenine glycosylase II C3Y97_19435 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C3Y97_19455 ENOG4105BZU Histidine kinase C3Y97_19470 ENOG4108DMA Nad-dependent epimerase dehydratase C3Y97_19495 ENOG41067MG lrgb family C3Y97_19515 ENOG4108S3Y transcriptional regulator C3Y97_19520 ENOG4105CS2 ec 3.2.1.21 C3Y97_19535 ENOG4105F0V Cell wall hydrolase C3Y97_19550 ENOG4105E0M Sulfatase C3Y97_19555 ENOG410890F Dynamin family C3Y97_19585 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C3Y97_19590 ENOG4105DQU oxidoreductase, subunit beta C3Y97_19595 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein C3Y97_19600 ENOG4108IGT Dipeptidase C3Y97_19605 ENOG4105MCT stage V sporulation protein S C3Y97_19610 ENOG4105D48 metallophosphoesterase C3Y97_19625 ENOG4105CEV competence damage-inducible protein C3Y97_19630 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C3Y97_19645 ENOG4105XZV Protein of unknown function (DUF3243) C3Y97_19650 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C3Y97_19670 ENOG4105UIB (ABC) transporter C3Y97_19675 ENOG4108JQ9 ABC transporter C3Y97_19680 ENOG4105DIH basic membrane C3Y97_19685 ENOG4105FDP GntR family transcriptional regulator C3Y97_19695 ENOG4105CNU cell division protein FtsK C3Y97_19705 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C3Y97_19715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C3Y97_19725 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C3Y97_19730 ENOG4108S0H Dipicolinic acid synthetase, b subunit C3Y97_19735 ENOG4105E35 Dipicolinate synthase subunit A C3Y97_19745 ENOG4105C1V Peptidase, M16 C3Y97_19765 ENOG4105DTN riboflavin biosynthesis protein ribF C3Y97_19780 ENOG4105W7A Protein of unknown function (DUF503) C3Y97_19790 ENOG4105VHM ribosomal protein C3Y97_19795 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C3Y97_19800 ENOG4105CHV Transcription elongation factor NusA C3Y97_19810 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C3Y97_19825 ENOG4105DZP Membrane-associated zinc metalloprotease C3Y97_19830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C3Y97_19835 ENOG4105KNE Phosphatidate cytidylyltransferase C3Y97_19840 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C3Y97_19850 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C3Y97_19880 ENOG4108HE4 integrase family C3Y97_19885 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C3Y97_19890 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C3Y97_19895 ENOG4105C79 DNA protecting protein DprA C3Y97_19900 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C3Y97_19915 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C3Y97_19940 ENOG4105VB6 UPF0109 protein C3Y97_19960 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C3Y97_19965 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C3Y97_19980 ENOG4105CHR reductase C3Y97_19985 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C3Y97_20000 ENOG4105CB5 ATP-dependent DNA helicase recG C3Y97_20005 ENOG4105DP4 dak2 domain fusion protein ylov C3Y97_20010 ENOG4108ZAA Alkaline-shock protein C3Y97_20025 ENOG4105FJ0 thiamine C3Y97_20030 ENOG4105DJV ribulose-phosphate 3-epimerase C3Y97_20035 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C3Y97_20040 ENOG4105D9P serine threonine protein kinase C3Y97_20045 ENOG4108ZF3 Phosphatase C3Y97_20050 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C3Y97_20055 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C3Y97_20070 ENOG4105C25 Primosomal protein n' C3Y97_20075 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C3Y97_20095 ENOG4105DSJ YicC domain protein C3Y97_20105 ENOG4105F23 Fibronectin-binding protein C3Y97_20110 ENOG4105DC7 peptidase M24 C3Y97_20135 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C3Y97_20150 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C3Y97_20155 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C3Y97_20165 ENOG4105CD3 dihydroorotase C3Y97_20185 ENOG4105C34 Pseudouridine synthase C3Y97_20200 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C3Y97_20210 ENOG4105DBK s4 domain protein C3Y97_20215 ENOG41067XK integral membrane protein C3Y97_20225 ENOG4105DFA alanine racemase domain protein C3Y97_20230 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C3Y97_20235 ENOG4105WR5 sporulation protein, YlmC YmxH family C3Y97_20245 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3Y97_20255 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C3Y97_20260 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C3Y97_20270 ENOG4105D4A Cell wall formation (By similarity) C3Y97_20275 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C3Y97_20280 ENOG4105CNI cell division protein FtsW C3Y97_20285 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C3Y97_20295 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C3Y97_20300 ENOG4105CJN penicillin-binding protein C3Y97_20305 ENOG4105CJN penicillin-binding protein C3Y97_20320 ENOG41074B2 UPF0747 protein C3Y97_20345 ENOG4105KNH Nucleic acid-binding protein C3Y97_20355 ENOG41063PX domain protein C3Y97_20360 ENOG4105D78 K07001 NTE family protein C3Y97_20365 ENOG4105H20 Sporulation integral membrane protein YlbJ C3Y97_20375 ENOG4106H78 methyltransferase C3Y97_20395 ENOG4107TB6 phosphoglycerate mutase C3Y97_20410 ENOG4106UY4 Inherit from COG: Scp-like extracellular C3Y97_20455 ENOG4107VFP cytochrome oxidase assembly C3Y97_20460 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C3Y97_20470 ENOG4105CNI cell division protein FtsW C3Y97_20485 ENOG4108IAB Phoh family C3Y97_20505 ENOG4105QA2 C3Y97_20510 ENOG4105CI3 gtp-binding protein typa C3Y97_20520 ENOG4105ECY inositol monophosphatase C3Y97_20540 ENOG4105CXN decarboxylase C3Y97_20590 ENOG4105CPP Dehydrogenase, E1 component C3Y97_20605 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C3Y97_20610 ENOG4108X4Q Hydrolase C3Y97_20625 ENOG4105CN5 Metallo-Beta-Lactamase C3Y97_20630 ENOG4107ZYR domain protein C3Y97_20665 ENOG4108XRC Protein of unknown function (DUF458) C3Y97_20675 ENOG4107IN1 Protein of unknown function (DUF1797) C3Y97_20690 ENOG4105EPM Diguanylate phosphodiesterase C3Y97_20695 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C3Y97_20710 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C3Y97_20720 ENOG4105UIN C3Y97_20755 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C3Y97_20780 ENOG4108HGU Histidine kinase C3Y97_20790 ENOG4105CHM Aminotransferase C3Y97_20795 ENOG4105FKQ transcriptional regulator C3Y97_20800 ENOG4105EG2 ABC transporter, permease C3Y97_20810 ENOG4107FKK extracellular solute-binding protein family 1 C3Y97_20820 ENOG4105CG3 alpha amylase, catalytic region C3Y97_20865 ENOG4105CHU acetyl-coa acetyltransferase C3Y97_20900 ENOG4105K7K Transcriptional regulator C3Y97_20905 ENOG4105DTD Dehydrogenase C3Y97_20925 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C3Y97_20935 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate C3Y97_20950 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C3Y97_20965 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C3Y97_20975 ENOG4105BZU Histidine kinase C3Y97_20995 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C3Y97_21010 ENOG4105CID antiterminator C3Y97_21020 ENOG4105FDP GntR family transcriptional regulator C3Y97_21030 ENOG4105CE4 GlcNAc 6-P deacetylase C3Y97_21070 ENOG4107ZE5 PPIases accelerate the folding of proteins C3Y97_21075 ENOG4105PTM secreted protein C3Y97_21080 ENOG4105J7I hydrolase C3Y97_21090 ENOG4105G6R Stage v sporulation protein ae C3Y97_21100 ENOG4105CZ3 stage V sporulation protein ad C3Y97_21105 ENOG41090VF Stage v sporulation protein ac C3Y97_21125 ENOG4105C8J )-transporter C3Y97_21130 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3Y97_21140 ENOG41082AN stage II sporulation protein C3Y97_21145 ENOG4105DZ1 carboxypeptidase C3Y97_21155 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C3Y97_21160 ENOG4105DVE abc transporter atp-binding protein C3Y97_21195 ENOG4105D7N magnesium and cobalt transport protein CorA C3Y97_21220 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C3Y97_21230 ENOG4105I3K Ferric uptake regulator, Fur family C3Y97_21235 ENOG4105MZ9 stage II sporulation protein m C3Y97_21255 ENOG4105CPC Aldo Keto reductase C3Y97_21265 ENOG4105RHY Pfam:UPF0157 C3Y97_21285 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C3Y97_21295 ENOG4105ETE Transcriptional regulator (LacI family C3Y97_21300 ENOG4108YM7 Gcn5-related n-acetyltransferase C3Y97_21320 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C3Y97_21325 ENOG4108R6K riboflavin synthase, subunit alpha C3Y97_21350 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3Y97_21355 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3Y97_21365 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C3Y97_21370 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3Y97_21385 ENOG4105DFD Na H antiporter C3Y97_21390 ENOG4105CGH 5'-nucleotidase C3Y97_21415 ENOG4105DBV ornithine carbamoyltransferase C3Y97_21430 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C3Y97_21445 ENOG4108IXY short-chain dehydrogenase reductase C3Y97_21450 ENOG41069FQ Metallo-beta-lactamase superfamily C3Y97_21455 ENOG4105II7 pyrroline-5-carboxylate reductase C3Y97_21460 ENOG4105EJQ L-serine dehydratase C3Y97_21475 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C3Y97_21490 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C3Y97_21505 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C3Y97_21510 ENOG4105D9U N-acetyltransferase C3Y97_21525 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C3Y97_21530 ENOG4108QEG Membrane C3Y97_21535 ENOG4105CDA abc transporter atp-binding protein C3Y97_21540 ENOG4105E5Q amino acid AbC transporter C3Y97_21545 ENOG4108HW3 (ABC) transporter C3Y97_21555 ENOG4105G7B Protein of unknown function (DUF2992) C3Y97_21565 ENOG4108QY0 Membrane C3Y97_21580 ENOG4105C7S Dehydrogenase C3Y97_21585 ENOG4105CPP Dehydrogenase, E1 component C3Y97_21600 ENOG4105CKM Branched-chain carboxylic acid kinase C3Y97_21605 ENOG4107RDP Dehydrogenase C3Y97_21620 ENOG4108JUB Transcriptional regulator C3Y97_21630 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3Y97_21645 ENOG4107QQR Sporulation C3Y97_21655 ENOG4105S1Z Stage IV sporulation protein B C3Y97_21660 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C3Y97_21665 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C3Y97_21670 ENOG4105DX0 Hemolysin A C3Y97_21680 ENOG4105CTB Polyprenyl synthetase C3Y97_21695 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C3Y97_21705 ENOG4108ZSR alkaline shock protein C3Y97_21710 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C3Y97_21735 ENOG410644B Stage III sporulation protein af C3Y97_21745 ENOG4105KQ4 Stage iii sporulation protein ad C3Y97_21750 ENOG4108CQH stage III sporulation protein AC C3Y97_21755 ENOG4105KR5 Stage iii sporulation protein C3Y97_21760 ENOG4105CD2 stage iii sporulation protein aa C3Y97_21785 ENOG4105DC7 peptidase M24 C3Y97_21790 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C3Y97_21800 ENOG4105CBJ Metal-dependent enzyme C3Y97_21810 ENOG4107YBY Hydrolase C3Y97_21840 ENOG41082GG biotin lipoate A B protein ligase C3Y97_21845 ENOG4105WZW rhodanese family C3Y97_21870 ENOG41080TC multidrug resistance protein C3Y97_21905 ENOG4105CJ1 ABC, transporter C3Y97_21910 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C3Y97_21925 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C3Y97_21945 ENOG4105C0D helicase C3Y97_22035 ENOG4107R6U sodium dicarboxylate symporter C3Y97_22070 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C3Y97_22075 ENOG4105C3R Methionine synthase C3Y97_22085 ENOG4105C28 cystathionine C3Y97_22090 ENOG4105C28 cystathionine C3Y97_22110 ENOG4105C5X domain protein C3Y97_22120 ENOG4105DKQ ROK family C3Y97_22130 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C3Y97_22145 ENOG4108UTW Plays a role in the regulation of phosphate uptake C3Y97_22150 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C3Y97_22155 ENOG4105C8U phosphate abc transporter C3Y97_22160 ENOG4105C8U phosphate abc transporter C3Y97_22165 ENOG4105EXS phosphate abc transporter C3Y97_22170 ENOG4107RF6 penicillin-binding protein C3Y97_22180 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3Y97_22205 ENOG4105N80 Ferric uptake regulator, Fur family C3Y97_22215 ENOG4105FDK ABC transporter C3Y97_22220 ENOG4108JYZ YitT family C3Y97_22225 ENOG41069ZM Protein of unknown function (DUF2624) C3Y97_22250 ENOG4105EGD dinuclear metal center protein, YbgI family C3Y97_22265 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3Y97_22270 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C3Y97_22285 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C3Y97_22305 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C3Y97_22310 ENOG4105KG3 cytidine deaminase C3Y97_22315 ENOG4107YR5 Diacylglycerol kinase C3Y97_22320 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C3Y97_22325 ENOG4105CTJ Metal Dependent Phosphohydrolase C3Y97_22330 ENOG4105C9A Phoh family C3Y97_22340 ENOG41068P3 sporulation protein YqfC C3Y97_22350 ENOG4105KTH gatB Yqey C3Y97_22365 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C3Y97_22370 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C3Y97_22400 ENOG4105CSA Coproporphyrinogen iii oxidase C3Y97_22405 ENOG4105KVH Transcriptional regulator C3Y97_22430 ENOG4105TQK DNA polymerase iii, delta' subunit C3Y97_22440 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C3Y97_22445 ENOG4108UK2 deaminase C3Y97_22450 ENOG4105KQC Competence protein C3Y97_22460 ENOG4105DXX methyltransferase C3Y97_22470 ENOG4108WF2 Metal Dependent Phosphohydrolase C3Y97_22480 ENOG410812S Rna-binding protein C3Y97_22490 ENOG4105CQW ribosome biogenesis GTPase YqeH C3Y97_22495 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C3Y97_22510 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3Y97_22530 ENOG4108TVJ Nitroreductase C3Y97_22545 ENOG4105G6Z alkaline phosphatase C3Y97_22550 ENOG4105KEG ribosomal-protein-alanine acetyltransferase C3Y97_22555 ENOG4108MUZ hydrolase C3Y97_22590 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C3Y97_22595 ENOG4105MIR Phenylalanine 4-monooxygenase C3Y97_22605 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C3Y97_22650 ENOG4105S6R Iron-hydroxamate transporter permease subunit C3Y97_22655 ENOG4108V5C ABC transporter C3Y97_22670 ENOG4108EKI Dehydrogenase C3Y97_22675 ENOG4105C28 cystathionine C3Y97_22705 ENOG4107XRG penicillin-binding protein C3Y97_22715 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C3Y97_22725 ENOG4105CFP Peptidase U32 C3Y97_22730 ENOG4105XYU peptidase (U32 family) C3Y97_22735 ENOG4108VQJ O-methyltransferase C3Y97_22740 ENOG4105HHA aminodeoxychorismate lyase C3Y97_22760 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C3Y97_22770 ENOG4105C02 permease C3Y97_22785 ENOG41060CR C3Y97_22790 ENOG4105C7H Helicase, RecD TraA family C3Y97_22800 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C3Y97_22805 ENOG4105C3J Cysteine desulfurase C3Y97_22815 ENOG4105D1H recombination factor protein RarA C3Y97_22820 ENOG4108VCI transcription factor, rsfa family C3Y97_22830 ENOG4105CUZ uba thif-type nad fad binding protein C3Y97_22840 ENOG4105CUT histidyl-tRNA synthetase C3Y97_22850 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C3Y97_22855 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C3Y97_22865 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C3Y97_22870 ENOG41076HS cation diffusion facilitator family transporter C3Y97_22875 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C3Y97_22885 ENOG4105CKP Polysaccharide Biosynthesis Protein C3Y97_22890 ENOG4108QG2 Membrane C3Y97_22900 ENOG4105VIE preprotein translocase, subunit YajC C3Y97_22915 ENOG41061AI Protein of unknown function (DUF2905) C3Y97_22930 ENOG4108HUF Transporter C3Y97_22955 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C3Y97_22960 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C3Y97_22965 ENOG4108IYU L-aspartate oxidase C3Y97_22980 ENOG4108RPX mosc domain containing protein C3Y97_22985 ENOG4105CQC Prephenate dehydratase C3Y97_23000 ENOG4105C19 ABC transporter C3Y97_23005 ENOG4105EWM Histidine kinase C3Y97_23015 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C3Y97_23030 ENOG4105X36 (ribosomal) protein C3Y97_23040 ENOG4105C03 ribonuclease C3Y97_23055 ENOG4107QMS site-determining protein C3Y97_23070 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C3Y97_23075 ENOG4105DFF Rod shape-determining protein mreb C3Y97_23095 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C3Y97_23100 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C3Y97_23110 ENOG41068KH stage VI sporulation protein D C3Y97_23120 ENOG4105D52 delta-aminolevulinic acid dehydratase C3Y97_23145 ENOG4105K56 Transcriptional regulator C3Y97_23165 ENOG4108IUQ atp-dependent protease C3Y97_23195 ENOG4108QCI YvbH-like oligomerisation region C3Y97_23245 ENOG4105MN3 Resolvase C3Y97_23295 ENOG4105M59 Phosphodiesterase, mj0936 family C3Y97_23300 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C3Y97_23310 ENOG4108XJQ germination protein C3Y97_23320 ENOG4108PCX Major Facilitator C3Y97_23330 ENOG4105KBX Transcriptional regulator, TetR family C3Y97_23340 ENOG4105PFC Transcriptional regulator C3Y97_23350 ENOG4105DZC cytosine deaminase C3Y97_23355 ENOG41067S9 phage shock protein C, PspC C3Y97_23360 ENOG4108JCI Transcriptional regulator C3Y97_23370 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C3Y97_23375 ENOG4108Z40 Transcriptional regulator C3Y97_23380 ENOG4105RHA ABC transporter, permease C3Y97_23385 ENOG4108IUX (ABC) transporter C3Y97_23390 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family C3Y97_23395 ENOG4105ER2 Ompa motb domain protein C3Y97_23400 ENOG4105E14 MotA TolQ exbB proton channel C3Y97_23410 ENOG4108VXD carboxy-peptidase C3Y97_23420 ENOG4105E33 succinate dehydrogenase C3Y97_23430 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C3Y97_23440 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C3Y97_23445 ENOG4105K63 Thioredoxin C3Y97_23450 ENOG4105C10 Electron transfer flavoprotein C3Y97_23455 ENOG4105BZJ Electron transfer flavoprotein C3Y97_23460 ENOG41060WC Enoyl-CoA hydratase C3Y97_23465 ENOG4107Z3H Transcriptional regulator, TetR family C3Y97_23470 ENOG4105CEY Amp-dependent synthetase and ligase C3Y97_23480 ENOG4105J76 Periplasmic binding protein C3Y97_23485 ENOG4105S6R Iron-hydroxamate transporter permease subunit C3Y97_23535 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3Y97_23550 ENOG4105DR4 Methyltransferase C3Y97_23565 ENOG4105KFN sortase, SrtB family C3Y97_23570 ENOG4105E0A ABC, transporter C3Y97_23585 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) C3Y97_23595 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) C3Y97_23605 ENOG4105FE9 pseudouridine synthase C3Y97_23620 ENOG4105DCG PHP domain protein C3Y97_23635 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C3Y97_23655 ENOG4105C5S asparaginyl-tRNA synthetase C3Y97_23660 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C3Y97_23670 ENOG4108RWN rrna methyltransferase C3Y97_23700 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3Y97_23705 ENOG4105CW7 secretion protein, HlyD family C3Y97_23710 ENOG4108JGH Tetr family transcriptional regulator C3Y97_23715 ENOG4105CN9 Peptidase m42 family protein C3Y97_23735 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C3Y97_23740 ENOG4105C22 threonyL-tRNA synthetase C3Y97_23745 ENOG4108TDW sporulation protein YtxC C3Y97_23770 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C3Y97_23780 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C3Y97_23785 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C3Y97_23795 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C3Y97_23800 ENOG4105C2M dna polymerase I C3Y97_23805 ENOG4105BZU Histidine kinase C3Y97_23810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3Y97_23830 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3Y97_23835 ENOG4108HMX isocitrate dehydrogenase (NADP) C3Y97_23840 ENOG4105BZN citrate synthase C3Y97_23855 ENOG4108REF Sporulation integral membrane protein ytvi C3Y97_23860 ENOG4105FS0 cytoplasmic membrane protein C3Y97_23885 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C3Y97_23890 ENOG4105C6K Malic enzyme C3Y97_23895 ENOG4105C0B DNA polymerase III (alpha subunit) C3Y97_23900 ENOG4105VV2 C3Y97_23910 ENOG4105SFS phosphoesterase RecJ domain protein C3Y97_23935 ENOG4105E8R UPF0173 metal-dependent hydrolase C3Y97_23940 ENOG4105DC7 peptidase M24 C3Y97_23980 ENOG4105Z7P Acetyltransferase (GNAT) family C3Y97_23985 ENOG41082W1 Cupin 2, conserved barrel domain protein C3Y97_24005 ENOG4107YZX Universal stress protein C3Y97_24025 ENOG4105CH7 arginosuccinase C3Y97_24055 ENOG4108JYZ YitT family C3Y97_24075 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C3Y97_24085 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C3Y97_24090 ENOG4105KBJ sporulation protein ytfj C3Y97_24105 ENOG4105EFZ amidohydrolase C3Y97_24115 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3Y97_24140 ENOG4106KR7 LysR family Transcriptional regulator C3Y97_24150 ENOG4105U5Y Transcriptional regulator C3Y97_24160 ENOG4105C28 cystathionine C3Y97_24195 ENOG4105EMN RNA polymerase sigma factor C3Y97_24205 ENOG4108UW5 maltose o-acetyltransferase C3Y97_24215 ENOG4105F1V Acetoin utilization protein C3Y97_24220 ENOG4105W87 Cbs domain C3Y97_24225 ENOG4105DGU Histone deacetylase C3Y97_24240 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3Y97_24250 ENOG4107SNB ankyrin repeat protein YahD C3Y97_24255 ENOG4105EP9 oxidoreductase C3Y97_24285 ENOG4105ETE Transcriptional regulator (LacI family C3Y97_24295 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C3Y97_24315 ENOG4105C88 aminopeptidase C3Y97_24360 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C3Y97_24370 ENOG4108VDD TRNA binding domain protein C3Y97_24400 ENOG4105C8F Beta-lactamase domain protein C3Y97_24415 ENOG4108V15 phosphotransferase enzyme family C3Y97_24420 ENOG4108IUM Glycogen debranching enzyme C3Y97_24430 ENOG4107QSE Dipeptidase C3Y97_24435 ENOG4105YW5 deoR family transcriptional regulator C3Y97_24450 ENOG4105CBX hi0933 family C3Y97_24490 ENOG4108VJ1 Transcriptional regulator (CarD family C3Y97_24495 ENOG4107EXU Short-chain dehydrogenase reductase Sdr C3Y97_24500 ENOG4105CSC Glucose uptake protein C3Y97_24515 ENOG4108ZAF Molybdopterin C3Y97_24520 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C3Y97_24525 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3Y97_24535 ENOG4105D06 uba thif-type nad fad binding protein C3Y97_24540 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3Y97_24565 ENOG41085GJ domain protein C3Y97_24575 ENOG4105DWV Homoserine O-trans-acetylase C3Y97_24585 ENOG4108B31 Spore germination protein C3Y97_24610 ENOG4105C8T Leucyl-tRNA synthetase C3Y97_24615 ENOG410605W Major Facilitator C3Y97_24625 ENOG4105NCW Trka-c domain protein C3Y97_24640 ENOG4105C19 ABC transporter C3Y97_24660 ENOG4105N5T Radical SAM Protein C3Y97_24695 ENOG4105E8V Alpha Beta Hydrolase Fold protein C3Y97_24700 ENOG4108Z0R Transferase C3Y97_24705 ENOG4105YVM Phosphoesterase, PA-phosphatase related C3Y97_24710 ENOG4105BZF Glycosyl transferase (Group 1 C3Y97_24720 ENOG4105EPU Molybdenum cofactor synthesis domain protein C3Y97_24730 ENOG4108MK9 spermidine N(1)-acetyltransferase C3Y97_24790 ENOG4105BZU Histidine kinase C3Y97_24795 ENOG4105BZU Histidine kinase C3Y97_24800 ENOG4105CH6 catalase C3Y97_24810 ENOG4107S9D Alpha beta hydrolase C3Y97_24815 ENOG4107T7U Sulfatase C3Y97_24830 ENOG4105D2X ABC transporter substrate-binding protein C3Y97_24840 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C3Y97_24905 ENOG4108V2W Carbonate dehydratase C3Y97_24910 ENOG4105C4M (Ubiquinol oxidase) subunit I C3Y97_24915 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C3Y97_24955 ENOG41087YS Phage shock protein A C3Y97_24985 ENOG4105BZU Histidine kinase C3Y97_24990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_25015 ENOG4108UGV hypoxanthine phosphoribosyltransferase C3Y97_25020 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C3Y97_25045 ENOG4105C19 ABC transporter C3Y97_25060 ENOG4107ZTW SNARE associated Golgi C3Y97_25065 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C3Y97_25075 ENOG4105C19 ABC transporter C3Y97_25080 ENOG41086D8 Transcriptional regulator C3Y97_25095 ENOG41082BM Transcriptional regulator, arsr family C3Y97_25145 ENOG4105C6Z Gluconate C3Y97_25150 ENOG4105FDP GntR family transcriptional regulator C3Y97_25170 ENOG41069H0 dihydroorotase EC 3.5.2.3 C3Y97_25205 ENOG4105DTQ mandelate racemase muconate lactonizing C3Y97_25210 ENOG4105CEY Amp-dependent synthetase and ligase C3Y97_25215 ENOG4108IPT Naphthoate synthase C3Y97_25220 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C3Y97_25225 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C3Y97_25230 ENOG4105E4F Isochorismate synthase C3Y97_25235 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C3Y97_25245 ENOG4105VEQ Cold shock protein C3Y97_25290 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C3Y97_25305 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C3Y97_25410 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C3Y97_25450 ENOG4105KT7 mgtC SapB transporter C3Y97_25455 ENOG4107PBV potassium channel C3Y97_25475 ENOG4105WG9 Conserved Protein C3Y97_25485 ENOG4105CHM Aminotransferase C3Y97_25490 ENOG4108ZB6 transcriptional regulator AsnC family C3Y97_25495 ENOG4105C5I Dehydrogenase C3Y97_25500 ENOG4108MUZ hydrolase C3Y97_25510 ENOG4105C87 Aminotransferase class I and II C3Y97_25520 ENOG4105Y38 Kinase-associated protein B C3Y97_25530 ENOG4107R3E Citrate transporter C3Y97_25550 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) C3Y97_25555 ENOG4105KA0 thioesterase Superfamily protein C3Y97_25570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C3Y97_25595 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) C3Y97_25600 ENOG4106YN8 Prenyltransferase C3Y97_25620 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) C3Y97_25625 ENOG4106YN8 Prenyltransferase C3Y97_25630 ENOG41069ER domain protein C3Y97_25645 ENOG4105CEP NADH dehydrogenase C3Y97_25675 ENOG4105EWC Purine nucleoside phosphorylase C3Y97_25695 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C3Y97_25720 ENOG4108JJA ABC, transporter C3Y97_25725 ENOG4105C4B ABC transporter, permease C3Y97_25730 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C3Y97_25760 ENOG41083MR nifu domain-containing protein C3Y97_25775 ENOG4108W5N phosphatidylglycerophosphatase a C3Y97_25795 ENOG4105DAX Pfam:DUF2983 C3Y97_25805 ENOG4105DYS nad(p)h dehydrogenase (quinone) C3Y97_25810 ENOG4105D4U had-superfamily hydrolase, subfamily iia C3Y97_25825 ENOG4105CBT Fructose-1,6-bisphosphatase C3Y97_25845 ENOG4105MMD transcriptional regulator C3Y97_25850 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C3Y97_25855 ENOG4107TXC Transcriptional regulator C3Y97_25860 ENOG41090T1 Membrane C3Y97_25885 ENOG4105FAA peptidase M23 C3Y97_25890 ENOG4108YTE sporulation protein YunB C3Y97_25895 ENOG4105KZD Domain of unknown function (DUF1805) C3Y97_25900 ENOG4107R8B 5'-nucleotidase C3Y97_25915 ENOG4105DIW FeS assembly protein SUFB C3Y97_25920 ENOG4108UNV SUF system FeS assembly protein, NifU family C3Y97_25925 ENOG4105C9B Cysteine desulfurase C3Y97_25930 ENOG4105JRK feS assembly protein SufD C3Y97_25935 ENOG4105C3K feS assembly ATPase SufC C3Y97_25940 ENOG4105D01 (LipO)protein C3Y97_25945 ENOG4105D01 (LipO)protein C3Y97_25950 ENOG4108UMI ABC transporter, permease C3Y97_25980 ENOG41080E8 Transcriptional regulator, Spx MgsR family C3Y97_26000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3Y97_26030 ENOG4108W8B Beta-lactamase domain protein C3Y97_26035 ENOG4105C1G acyl-Coa dehydrogenase C3Y97_26040 ENOG4105CHU acetyl-coa acetyltransferase C3Y97_26060 ENOG4105DZ1 carboxypeptidase C3Y97_26080 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C3Y97_26095 ENOG4108SUT Major Facilitator Superfamily C3Y97_26100 ENOG4107R7I amino acid C3Y97_26115 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C3Y97_26125 ENOG4107AYK membrAne C3Y97_26165 ENOG4107ZTW SNARE associated Golgi C3Y97_26175 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C3Y97_26180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_26185 ENOG4105BZU Histidine kinase C3Y97_26200 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C3Y97_26215 ENOG4105C8Q Methyl-accepting chemotaxis C3Y97_26220 ENOG4105VG1 fes assembly suf system protein C3Y97_26225 ENOG4105D4Y metalloprotease C3Y97_26245 ENOG4107T5V SNARE associated Golgi C3Y97_26250 ENOG4107S91 Sodium hydrogen exchanger C3Y97_26255 ENOG4105NCW Trka-c domain protein C3Y97_26275 ENOG4108RMU ferritin dps family protein C3Y97_26290 ENOG4108URH decarboxylase C3Y97_26300 ENOG41090A1 ferritin C3Y97_26310 ENOG4105D9N nucleoside C3Y97_26315 ENOG4105D9N nucleoside C3Y97_26330 ENOG4108RYK Nad-dependent epimerase dehydratase C3Y97_26350 ENOG4105CV8 reductase C3Y97_26355 ENOG4105F27 Major Facilitator C3Y97_26360 ENOG4105KVH Transcriptional regulator C3Y97_26375 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C3Y97_26380 ENOG4105D4A Cell wall formation (By similarity) C3Y97_26390 ENOG4105C8Q Methyl-accepting chemotaxis C3Y97_26400 ENOG4105WMR Protein CrcB homolog C3Y97_26405 ENOG4105WMR Protein CrcB homolog C3Y97_26425 ENOG4105C5H ABC transporter C3Y97_26430 ENOG4108MK9 spermidine N(1)-acetyltransferase C3Y97_26435 ENOG4108VY7 phosphate-starvation-inducible protein PsiE C3Y97_26475 ENOG4108IPW abc transporter atp-binding protein C3Y97_26480 ENOG4105CM4 permease protein C3Y97_26520 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C3Y97_26530 ENOG4105XZU Preprotein translocase, subunit SecG C3Y97_26535 ENOG41067MG lrgb family C3Y97_26555 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C3Y97_26585 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3Y97_26605 ENOG41090VF Stage v sporulation protein ac C3Y97_26610 ENOG4105CZ3 stage V sporulation protein ad C3Y97_26625 ENOG4108QY0 Membrane C3Y97_26630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C3Y97_26635 ENOG4105KRI phosphocarrier protein (HPr C3Y97_26645 ENOG4105CHW UPF0052 protein C3Y97_26650 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C3Y97_26655 ENOG4108Z4K mutator MutT protein C3Y97_26665 ENOG4105C3M thioredoxin reductase C3Y97_26675 ENOG4108S4C acetyltransferase C3Y97_26685 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C3Y97_26695 ENOG41086DT Membrane protein of unknown function C3Y97_26705 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C3Y97_26725 ENOG4107TXC Transcriptional regulator C3Y97_26745 ENOG4105DUM transcriptional regulator, lysR family C3Y97_26755 ENOG4108WS4 fmn reductase C3Y97_26770 ENOG4105BZ1 (ABC) transporter C3Y97_26780 ENOG4105CN1 protease C3Y97_26785 ENOG4105CRP Part of the ABC transporter FtsEX involved in C3Y97_26790 ENOG4105CAK Cell division ATP-binding protein ftsE C3Y97_26820 ENOG4105MS2 ribosomal subunit Interface protein C3Y97_26825 ENOG4105VEQ Cold shock protein C3Y97_26830 ENOG41081UC Inherit from COG: Competence protein C3Y97_26845 ENOG4105KVH Transcriptional regulator C3Y97_26860 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C3Y97_26865 ENOG4108KGH TRANSCRIPTIONal C3Y97_26870 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C3Y97_26875 ENOG4105C6Y Udp-glucose 6-dehydrogenase C3Y97_26880 ENOG4105ESV Glycosyl transferase, family 4 C3Y97_26890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C3Y97_26910 ENOG4105F8D glycoside hydrolase family 4 C3Y97_26915 ENOG4105VCP PTS System C3Y97_26920 ENOG4105CK1 PTS System C3Y97_26930 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C3Y97_26935 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C3Y97_26940 ENOG4105VCP PTS System C3Y97_26950 ENOG4105VZJ PTS System C3Y97_26970 ENOG4105ECB domain protein C3Y97_26975 ENOG4107RSM transcriptional regulator C3Y97_27025 ENOG4105DAA L-lactate C3Y97_27035 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) C3Y97_27050 ENOG4105E0M Sulfatase C3Y97_27080 ENOG4107R8N Glycosyl transferase, family 2 C3Y97_27090 ENOG4105C94 Transporter C3Y97_27100 ENOG41069ER domain protein C3Y97_27130 ENOG4105KBK Zinc finger, swim domain protein C3Y97_27135 ENOG4105C0D helicase C3Y97_27165 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3Y97_27175 ENOG4107RBB ABC transporter, permease C3Y97_27180 ENOG4105C19 ABC transporter C3Y97_27200 ENOG4105CXY transporter C3Y97_27215 ENOG4105BZU Histidine kinase C3Y97_27220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_27225 ENOG4105CMR udp-glucose 4-epimerase C3Y97_27235 ENOG4108KGH TRANSCRIPTIONal C3Y97_27245 ENOG4107TAE Glycosyl transferase (Group 1 C3Y97_27250 ENOG4105K64 Glycosyl transferase, family 2 C3Y97_27280 ENOG4105D3Q Sugar transferase C3Y97_27285 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C3Y97_27290 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C3Y97_27295 ENOG4107YJ4 chain length determinant protein C3Y97_27300 ENOG4105HTX biosynthesis protein C3Y97_27305 ENOG4108QV3 biosynthesis protein C3Y97_27320 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C3Y97_27335 ENOG4105FRN stage II sporulation protein C3Y97_27350 ENOG4105DY9 regulatoR C3Y97_27370 ENOG4106778 Protein of unknown function (DUF1146) C3Y97_27375 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3Y97_27380 ENOG4105C8S subunit m C3Y97_27385 ENOG4105D65 subunit l C3Y97_27410 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3Y97_27415 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3Y97_27425 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3Y97_27430 ENOG4105BZU Histidine kinase C3Y97_27480 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) C3Y97_27485 ENOG41062M3 atp synthase C3Y97_27505 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C3Y97_27510 ENOG4108UIC UPF0340 protein C3Y97_27515 ENOG4108YZG isomerase C3Y97_27535 ENOG4108VGI doxx family C3Y97_27540 ENOG4107XC4 flavin reductase domain protein, FMN-binding C3Y97_27560 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C3Y97_27570 ENOG4108ZXQ stage ii sporulation protein r C3Y97_27575 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3Y97_27580 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C3Y97_27585 ENOG4107104 thymidine kinase C3Y97_27600 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C3Y97_27605 ENOG4105CBT Fructose-1,6-bisphosphatase C3Y97_27610 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C3Y97_27630 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C3Y97_27645 ENOG4105C1G acyl-Coa dehydrogenase C3Y97_27650 ENOG4105C1G acyl-Coa dehydrogenase C3Y97_27655 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3Y97_27665 ENOG4105DF6 Fe-S oxidoreductase C3Y97_27680 ENOG4105BZU Histidine kinase C3Y97_27695 ENOG4105D4Y metalloprotease C3Y97_27705 ENOG4105BZU Histidine kinase C3Y97_27710 ENOG4105KCT ABC transporter C3Y97_27715 ENOG4108M15 ABC transporter C3Y97_27720 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C3Y97_27730 ENOG4105IIU Aminopeptidase C3Y97_27750 ENOG410904A RNA polymerase C3Y97_27755 ENOG4105DU6 RNA polymerase C3Y97_27765 ENOG410684U Domain of unknown function (DUF1934) C3Y97_27785 ENOG4105CYW agmatinase C3Y97_27795 ENOG4105DXB Major Facilitator superfamily C3Y97_27800 ENOG4107SWG transcriptional regulator MERR family C3Y97_27805 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3Y97_27810 ENOG4105BZ4 penicillin-binding protein C3Y97_27815 ENOG4108XFG YwhD family C3Y97_27820 ENOG4108Z4T Peptidase M50 C3Y97_27825 ENOG41069HH 4-oxalocrotonate tautomerase C3Y97_27830 ENOG4105DCI Phosphohydrolase C3Y97_27835 ENOG4108MES Periplasmic binding protein C3Y97_27840 ENOG4105E0A ABC, transporter C3Y97_27845 ENOG4105EHG Permease protein C3Y97_27850 ENOG4105DQ5 transport system permease protein C3Y97_27860 ENOG4108VCI transcription factor, rsfa family C3Y97_27865 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C3Y97_27870 ENOG4108IJ2 phosphate acetyltransferase C3Y97_27875 ENOG4107UEZ chlorite dismutase C3Y97_27885 ENOG4108VKI Cell wall hydrolase C3Y97_27905 ENOG4107SVH Potassium channel protein C3Y97_27915 ENOG410667J hydrolase C3Y97_27920 ENOG4105VCH membrane C3Y97_27930 ENOG4108TU7 Inherit from COG: (ABC) transporter C3Y97_27935 ENOG4105CJ1 ABC, transporter C3Y97_27940 ENOG41090WU lipolytic protein G-D-S-L family C3Y97_27955 ENOG4105D6E homoserine dehydrogenase C3Y97_27980 ENOG4108Y4K DNA-binding transcriptional activator C3Y97_27990 ENOG4105WH1 Two component transcriptional regulator luxr family C3Y97_27995 ENOG4105BZU Histidine kinase C3Y97_28000 ENOG4105DWF phosphomethylpyrimidine kinase C3Y97_28005 ENOG4105BZU Histidine kinase C3Y97_28010 ENOG4105VCD cytoplasmic protein C3Y97_28015 ENOG4105D22 carbon starvation protein C3Y97_28020 ENOG4105DY9 regulatoR C3Y97_28025 ENOG41079KZ Major Facilitator Superfamily C3Y97_28040 ENOG4105CG5 Glycosyl transferase (Group 1 C3Y97_28050 ENOG4105EN6 Membrane C3Y97_28055 ENOG4106YBV Methyl-accepting chemotaxis C3Y97_28065 ENOG4108S4H thioesterase Superfamily protein C3Y97_28075 ENOG4105K64 Glycosyl transferase, family 2 C3Y97_28090 ENOG4105CKK Glycosyl transferase, family 2 C3Y97_28095 ENOG4105C5H ABC transporter C3Y97_28100 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C3Y97_28110 ENOG41067SE Tetr family transcriptional regulator C3Y97_28120 ENOG4105E0X reductase C3Y97_28125 ENOG4106F5Q Membrane C3Y97_28140 ENOG4108NEV two component transcriptional regulator, LytTR family C3Y97_28150 ENOG4107RGD Major Facilitator superfamily C3Y97_28170 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3Y97_28180 ENOG4105IW1 AmiS UreI transporter C3Y97_28190 ENOG4105CMR udp-glucose 4-epimerase C3Y97_28195 ENOG4108UT2 hemolysin iii C3Y97_28205 ENOG4105C1J atp-dependent rna helicase C3Y97_28210 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) C3Y97_28215 ENOG4105DPN Oligoendopeptidase f C3Y97_28225 ENOG4105BZU Histidine kinase C3Y97_28230 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C3Y97_28240 ENOG4105C0H protease C3Y97_28245 ENOG4105Q2H domain protein C3Y97_28260 ENOG4105BZU Histidine kinase C3Y97_28265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3Y97_28290 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C3Y97_28295 ENOG4105CDU Replicative dna helicase C3Y97_28305 ENOG4105BZR domain protein C3Y97_28310 ENOG4108XMW Membrane C3Y97_28320 ENOG4108UUM single-stranded DNA-binding protein C3Y97_28330 ENOG4105C3G gtp-binding protein C3Y97_28335 ENOG4105VDK protein, conserved in bacteria C3Y97_28340 ENOG4105D8X mechanosensitive ion channel C3Y97_28345 ENOG4108ZDA Sporulation protein YyaC C3Y97_28350 ENOG4105FA0 parb-like partition protein C3Y97_28355 ENOG4107QJE Chromosome Partitioning Protein C3Y97_28370 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C3Y97_28375 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C3Y97_28385 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins