locus-tag	class	description
LIT25_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LIT25_00010	COG0592	DNA-directed DNA polymerase activity
LIT25_00015	COG2501	S4 domain
LIT25_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LIT25_00030	COG0187	DNA topoisomerase II activity
LIT25_00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LIT25_00055	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LIT25_00090	COG0516	GMP reductase activity
LIT25_00090	COG0517	IMP dehydrogenase activity
LIT25_00095	COG1686	Belongs to the peptidase S11 family
LIT25_00105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LIT25_00110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LIT25_00120	COG1428	Deoxynucleoside kinase
LIT25_00125	COG1428	Deoxynucleoside kinase
LIT25_00130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LIT25_00135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LIT25_00140	COG0179	Fumarylacetoacetate (FAA) hydrolase
LIT25_00150	COG1388	LysM domain
LIT25_00150	COG3858	chitin binding
LIT25_00155	COG1335	isochorismatase
LIT25_00160	COG0590	tRNA wobble adenosine to inosine editing
LIT25_00170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LIT25_00175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LIT25_00180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LIT25_00225	COG1982	Orn Lys Arg decarboxylase major
LIT25_00230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LIT25_00235	COG3870	Protein conserved in bacteria
LIT25_00240	COG1728	Protein conserved in bacteria
LIT25_00245	COG0470	DNA polymerase III
LIT25_00250	COG1774	PSP1 C-terminal conserved region
LIT25_00255	COG4467	Involved in initiation control of chromosome replication
LIT25_00260	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LIT25_00265	COG2827	Endonuclease containing a URI domain
LIT25_00270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LIT25_00275	COG2002	toxin-antitoxin pair type II binding
LIT25_00285	COG0084	hydrolase, TatD family'
LIT25_00290	COG3583	domain protein
LIT25_00290	COG3584	3D domain protein
LIT25_00295	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LIT25_00300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LIT25_00310	COG4466	Protein conserved in bacteria
LIT25_00320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LIT25_00325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LIT25_00330	COG0251	oxidation-reduction process
LIT25_00340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LIT25_00350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LIT25_00355	COG0193	aminoacyl-tRNA hydrolase activity
LIT25_00365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LIT25_00370	COG2002	toxin-antitoxin pair type II binding
LIT25_00375	COG2244	polysaccharide biosynthetic process
LIT25_00380	COG3956	TIGRFAM MazG family protein
LIT25_00385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LIT25_00400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LIT25_00405	COG1098	S1 RNA binding domain
LIT25_00420	COG2208	phosphoserine phosphatase activity
LIT25_00425	COG2304	oxidoreductase activity
LIT25_00430	COG0515	serine threonine protein kinase
LIT25_00435	COG0037	tRNA processing
LIT25_00440	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LIT25_00445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LIT25_00450	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LIT25_00455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LIT25_00460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LIT25_00465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LIT25_00470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LIT25_00475	COG0512	Glutamine amidotransferase of anthranilate synthase
LIT25_00480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LIT25_00485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LIT25_00490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LIT25_00495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LIT25_00500	COG1396	sequence-specific DNA binding
LIT25_00505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LIT25_00595	COG3880	PFAM UvrB UvrC protein
LIT25_00600	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LIT25_00605	COG0542	response to heat
LIT25_00610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LIT25_00615	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
LIT25_00620	COG4956	integral membrane protein (PIN domain superfamily)
LIT25_00625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LIT25_00635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LIT25_00640	COG1045	serine acetyltransferase
LIT25_00645	COG0215	cysteine-tRNA ligase activity
LIT25_00650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LIT25_00655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LIT25_00660	COG3688	RNA-binding protein containing a PIN domain
LIT25_00670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LIT25_00675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LIT25_00680	COG0250	Participates in transcription elongation, termination and antitermination
LIT25_00685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LIT25_00690	COG0081	regulation of translation
LIT25_00695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LIT25_00700	COG0222	ribosome binding
LIT25_00705	COG2813	Specifically methylates the guanine in position
LIT25_00710	COG0085	RNA polymerase activity
LIT25_00715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LIT25_00720	COG1358	cellular component organization or biogenesis
LIT25_00730	COG0049	tRNA binding
LIT25_00735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LIT25_00740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LIT25_00745	COG0051	transcription antitermination factor activity, RNA binding
LIT25_00750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LIT25_00755	COG0088	Forms part of the polypeptide exit tunnel
LIT25_00760	COG0089	rRNA binding
LIT25_00765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LIT25_00770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LIT25_00775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LIT25_00780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LIT25_00785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LIT25_00790	COG0255	Belongs to the universal ribosomal protein uL29 family
LIT25_00795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LIT25_00800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LIT25_00815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LIT25_00820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LIT25_00835	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LIT25_00840	COG1841	ribosomal large subunit assembly
LIT25_00845	COG0200	Binds to the 23S rRNA
LIT25_00850	COG0201	protein transport
LIT25_00855	COG0563	adenylate kinase activity
LIT25_00860	COG0024	Methionine aminopeptidase
LIT25_00865	COG2163	COG2163 Ribosomal protein L14E L6E L27E
LIT25_00870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LIT25_00875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LIT25_00880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LIT25_00885	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LIT25_00890	COG0202	RNA polymerase activity
LIT25_00895	COG0203	ribosomal protein L17
LIT25_00900	COG1122	ATPase activity
LIT25_00905	COG1122	ATPase activity
LIT25_00910	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LIT25_00920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LIT25_00925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LIT25_00980	COG4842	Belongs to the WXG100 family
LIT25_00995	COG1659	Linocin_M18 bacteriocin protein
LIT25_01030	COG0860	N-Acetylmuramoyl-L-alanine amidase
LIT25_01035	COG0489	protein tyrosine kinase activity
LIT25_01045	COG2194	sulfuric ester hydrolase activity
LIT25_01050	COG0726	polysaccharide deacetylase
LIT25_01130	COG1595	DNA-templated transcription, initiation
LIT25_01135	COG5662	AntiSigma factor
LIT25_01140	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LIT25_01145	COG4856	YbbR-like protein
LIT25_01150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LIT25_01155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LIT25_01160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LIT25_01165	COG0697	spore germination
LIT25_01185	COG2340	Cysteine-rich secretory protein family
LIT25_01190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LIT25_01195	COG0628	permease
LIT25_01210	COG4175	Glycine betaine
LIT25_01210	COG0517	IMP dehydrogenase activity
LIT25_01215	COG1764	response to oxidative stress
LIT25_01240	COG1695	Transcriptional regulator
LIT25_01245	COG0346	lactoylglutathione lyase activity
LIT25_01250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LIT25_01255	COG1214	PFAM Peptidase M22, glycoprotease
LIT25_01255	COG0456	acetyltransferase
LIT25_01270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LIT25_01275	COG0346	lactoylglutathione lyase activity
LIT25_01280	COG1132	(ABC) transporter
LIT25_01285	COG3403	YqcI/YcgG family
LIT25_01300	COG2226	methyltransferase
LIT25_01315	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_01320	COG1131	(ABC) transporter
LIT25_01325	COG1511	domain protein
LIT25_01325	COG0842	Transport permease protein
LIT25_01345	COG1309	transcriptional regulator
LIT25_01360	COG2188	Transcriptional regulator
LIT25_01365	COG1131	(ABC) transporter
LIT25_01375	COG0628	permease
LIT25_01380	COG0586	Pfam SNARE associated Golgi protein
LIT25_01395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_01400	COG1181	Belongs to the D-alanine--D-alanine ligase family
LIT25_01405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LIT25_01425	COG3402	PFAM membrane-flanked domain
LIT25_01430	COG3428	Bacterial PH domain
LIT25_01435	COG0705	Rhomboid family
LIT25_01440	COG0736	holo-[acyl-carrier-protein] synthase activity
LIT25_01445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LIT25_01450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LIT25_01455	COG0864	Transcriptional regulator
LIT25_01460	COG2337	Toxic component of a toxin-antitoxin (TA) module
LIT25_01465	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_01470	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_01475	COG2172	sigma factor antagonist activity
LIT25_01480	COG2208	phosphoserine phosphatase activity
LIT25_01485	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_01490	COG2172	sigma factor antagonist activity
LIT25_01495	COG1191	sigma factor activity
LIT25_01500	COG2208	phosphoserine phosphatase activity
LIT25_01505	COG2183	response to ionizing radiation
LIT25_01515	COG3091	SprT-like family
LIT25_01605	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LIT25_01610	COG0802	atpase or kinase
LIT25_01615	COG1214	PFAM Peptidase M22, glycoprotease
LIT25_01620	COG0456	acetyltransferase
LIT25_01630	COG0488	(ABC) transporter
LIT25_01635	COG0315	cyclic pyranopterin monophosphate synthase activity
LIT25_01640	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LIT25_01645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_01650	COG0805	protein transport
LIT25_01660	COG1266	CAAX protease self-immunity
LIT25_01665	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LIT25_01670	COG0459	protein refolding
LIT25_01700	COG1396	sequence-specific DNA binding
LIT25_01710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_01745	COG1609	Transcriptional regulator
LIT25_01750	COG3459	Glycosyltransferase 36 associated
LIT25_01755	COG1472	Belongs to the glycosyl hydrolase 3 family
LIT25_01770	COG0395	ABC-type sugar transport system, permease component
LIT25_01785	COG2329	Antibiotic biosynthesis monooxygenase
LIT25_01800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LIT25_01805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LIT25_01810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LIT25_01815	COG1120	ATPase activity
LIT25_01820	COG0492	ferredoxin-NADP+ reductase activity
LIT25_01835	COG0714	Associated with various cellular activities
LIT25_01840	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
LIT25_01845	COG1305	Transglutaminase-like
LIT25_01850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LIT25_01850	COG0519	Catalyzes the synthesis of GMP from XMP
LIT25_01855	COG2252	PERMEase
LIT25_01915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LIT25_01920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LIT25_01925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LIT25_01930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LIT25_01935	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LIT25_01940	COG0047	phosphoribosylformylglycinamidine synthase activity
LIT25_01945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LIT25_01950	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LIT25_01955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LIT25_01960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LIT25_01965	COG0138	bifunctional purine biosynthesis protein purh
LIT25_01970	COG0151	Belongs to the GarS family
LIT25_01985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LIT25_01990	COG1470	cell adhesion involved in biofilm formation
LIT25_01995	COG4496	protein, YerC YecD
LIT25_02010	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LIT25_02015	COG0210	DNA helicase
LIT25_02025	COG4851	CamS sex pheromone cAM373 precursor
LIT25_02030	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_02035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LIT25_02045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LIT25_02050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LIT25_02055	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LIT25_02065	COG1609	Transcriptional regulator
LIT25_02085	COG0154	amidase activity
LIT25_02095	COG1597	lipid kinase activity
LIT25_02100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LIT25_02120	COG2814	Major facilitator Superfamily
LIT25_02145	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_02210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LIT25_02225	COG4807	Protein conserved in bacteria
LIT25_02235	COG2234	aminopeptidase activity
LIT25_02240	COG2234	aminopeptidase activity
LIT25_02250	COG1404	Belongs to the peptidase S8 family
LIT25_02265	COG1131	(ABC) transporter
LIT25_02275	COG4122	O-methyltransferase activity
LIT25_02305	COG0681	Belongs to the peptidase S26 family
LIT25_02320	COG0737	Belongs to the 5'-nucleotidase family
LIT25_02325	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LIT25_02330	COG1595	DNA-templated transcription, initiation
LIT25_02335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LIT25_02340	COG1279	arginine transmembrane transporter activity
LIT25_02345	COG3290	protein histidine kinase activity
LIT25_02350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LIT25_02470	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
LIT25_02475	COG3853	Toxic anion resistance protein (TelA)
LIT25_02485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LIT25_02495	COG0166	Belongs to the GPI family
LIT25_02510	COG5444	nuclease activity
LIT25_02570	COG0494	nUDIX hydrolase
LIT25_02575	COG1335	isochorismatase
LIT25_02580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LIT25_02590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LIT25_02595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LIT25_02620	COG4565	transcriptional regulatory protein
LIT25_02650	COG2966	Psort location CytoplasmicMembrane, score
LIT25_02655	COG3610	response to peptide
LIT25_02665	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_02670	COG1115	amino acid carrier protein
LIT25_02675	COG1132	(ABC) transporter
LIT25_02680	COG1132	(ABC) transporter
LIT25_02705	COG0411	ABC transporter
LIT25_02715	COG0477	Major facilitator Superfamily
LIT25_02720	COG3162	membrane
LIT25_02725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LIT25_02740	COG1966	Carbon starvation protein
LIT25_02760	COG2356	endonuclease I
LIT25_02775	COG0488	(ABC) transporter
LIT25_02780	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_02800	COG4585	Histidine kinase
LIT25_02805	COG2197	response regulator
LIT25_02810	COG0402	S-adenosylhomocysteine deaminase activity
LIT25_02815	COG0402	S-adenosylhomocysteine deaminase activity
LIT25_02830	COG3842	ATPase activity
LIT25_02835	COG1178	ABC-type Fe3 transport system permease component
LIT25_02840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LIT25_02845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LIT25_02855	COG1349	DNA-binding transcription factor activity
LIT25_02870	COG1113	amino acid transport
LIT25_02880	COG1295	ribonuclease BN
LIT25_02890	COG2190	(PTS) system
LIT25_02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_02890	COG1263	PTS System
LIT25_02895	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
LIT25_02900	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_02910	COG2204	response regulator
LIT25_02915	COG3829	transcription factor binding
LIT25_02920	COG1509	lysine 2,3-aminomutase activity
LIT25_02935	COG1141	Ferredoxin
LIT25_02940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LIT25_02945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LIT25_02950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LIT25_02955	COG0183	Belongs to the thiolase family
LIT25_02960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LIT25_02965	COG0833	amino acid
LIT25_02980	COG2197	response regulator
LIT25_03010	COG0415	Belongs to the DNA photolyase family
LIT25_03030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_03030	COG1263	PTS System
LIT25_03035	COG0366	Alpha amylase catalytic
LIT25_03040	COG2188	Transcriptional regulator
LIT25_03070	COG1073	alpha beta
LIT25_03075	COG0737	Belongs to the 5'-nucleotidase family
LIT25_03080	COG0693	protein deglycase activity
LIT25_03090	COG4840	Belongs to the UPF0435 family
LIT25_03095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LIT25_03105	COG1295	ribonuclease BN
LIT25_03115	COG0477	Major facilitator Superfamily
LIT25_03120	COG3871	stress protein (general stress protein 26)
LIT25_03125	COG0387	Pfam Sodium calcium exchanger
LIT25_03130	COG2364	Membrane
LIT25_03145	COG0535	radical SAM domain protein
LIT25_03165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LIT25_03170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LIT25_03175	COG0513	Belongs to the DEAD box helicase family
LIT25_03180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LIT25_03185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LIT25_03205	COG0402	S-adenosylhomocysteine deaminase activity
LIT25_03210	COG1090	epimerase
LIT25_03215	COG2137	regulation of response to DNA damage stimulus
LIT25_03220	COG4221	oxidoreductase activity
LIT25_03245	COG1988	membrane-bound metal-dependent
LIT25_03250	COG1194	a g-specific adenine glycosylase
LIT25_03260	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_03275	COG3557	Belongs to the UPF0374 family
LIT25_03280	COG1132	(ABC) transporter
LIT25_03285	COG0444	Belongs to the ABC transporter superfamily
LIT25_03290	COG4608	Belongs to the ABC transporter superfamily
LIT25_03295	COG0747	negative chemotaxis
LIT25_03300	COG0601	transmembrane transport
LIT25_03305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LIT25_03310	COG1388	LysM domain
LIT25_03320	COG4129	membrane
LIT25_03325	COG0067	glutamate synthase
LIT25_03325	COG0069	glutamate synthase activity
LIT25_03325	COG0070	glutamate synthase
LIT25_03330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LIT25_03335	COG0725	ABC transporter, periplasmic molybdate-binding protein
LIT25_03340	COG4149	molybdate abc transporter
LIT25_03350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LIT25_03355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LIT25_03360	COG0735	belongs to the Fur family
LIT25_03515	COG2972	Histidine kinase
LIT25_03520	COG2207	Transcriptional regulator
LIT25_03520	COG4753	response regulator
LIT25_03530	COG3382	B3 4 domain protein
LIT25_03545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LIT25_03550	COG2766	serine protein kinase
LIT25_03560	COG2718	Belongs to the UPF0229 family
LIT25_03565	COG0501	Belongs to the peptidase M48B family
LIT25_03595	COG2205	protein histidine kinase activity
LIT25_03600	COG0745	RESPONSE REGULATOR receiver
LIT25_03605	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LIT25_03645	COG1404	Belongs to the peptidase S8 family
LIT25_03660	COG1653	transport
LIT25_03665	COG1175	transmembrane transport
LIT25_03670	COG0395	ABC-type sugar transport system, permease component
LIT25_03685	COG3290	protein histidine kinase activity
LIT25_03690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LIT25_03695	COG1301	dicarboxylic acid transport
LIT25_03700	COG1392	Phosphate transport regulator
LIT25_03705	COG0306	phosphate transporter
LIT25_03710	COG0778	Nitroreductase
LIT25_03715	COG2249	NAD(P)H dehydrogenase (quinone) activity
LIT25_03725	COG2259	Doxx family
LIT25_03745	COG1131	(ABC) transporter
LIT25_03750	COG4989	oxidoreductase activity
LIT25_03755	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LIT25_03760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_03765	COG3540	Alkaline phosphatase
LIT25_03770	COG2217	Heavy metal translocating P-type atpase
LIT25_03775	COG0656	L-ascorbic acid biosynthetic process
LIT25_03780	COG3764	Sortase (surface protein transpeptidase)
LIT25_03785	COG0456	acetyltransferase
LIT25_03790	COG0564	pseudouridine synthase activity
LIT25_03810	COG0517	IMP dehydrogenase activity
LIT25_03815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LIT25_03820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LIT25_03820	COG3153	acetyltransferase
LIT25_03825	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LIT25_03830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LIT25_03840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LIT25_03845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LIT25_03855	COG4585	Histidine kinase
LIT25_03855	COG2203	Gaf domain
LIT25_03860	COG2197	response regulator
LIT25_03865	COG0431	NADPH-dependent FMN reductase
LIT25_03875	COG2323	membrane
LIT25_03890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LIT25_03895	COG4209	transmembrane transport
LIT25_03900	COG0395	ABC-type sugar transport system, permease component
LIT25_03915	COG1609	Transcriptional regulator
LIT25_03920	COG1397	ADP-ribosylglycohydrolase
LIT25_03925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LIT25_03930	COG2382	esterase
LIT25_03930	COG3507	Belongs to the glycosyl hydrolase 43 family
LIT25_03930	COG3693	PFAM glycoside hydrolase, family 10
LIT25_03935	COG1959	2 iron, 2 sulfur cluster binding
LIT25_03945	COG2719	SpoVR family
LIT25_03960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_04030	COG1793	dna ligase
LIT25_04035	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
LIT25_04045	COG1793	dna ligase
LIT25_04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_04055	COG1404	Belongs to the peptidase S8 family
LIT25_04065	COG1120	ATPase activity
LIT25_04070	COG2207	Transcriptional regulator
LIT25_04075	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LIT25_04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LIT25_04085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LIT25_04095	COG0640	Transcriptional regulator
LIT25_04100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LIT25_04115	COG1363	Peptidase, m42
LIT25_04125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LIT25_04130	COG0745	RESPONSE REGULATOR receiver
LIT25_04135	COG5002	protein histidine kinase activity
LIT25_04140	COG1999	signal sequence binding
LIT25_04160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LIT25_04170	COG0506	proline dehydrogenase activity
LIT25_04175	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_04180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LIT25_04185	COG2508	Transcriptional regulator
LIT25_04190	COG1742	UPF0060 membrane protein
LIT25_04195	COG3339	Conserved Protein
LIT25_04205	COG2738	Putative neutral zinc metallopeptidase
LIT25_04210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LIT25_04220	COG3829	transcription factor binding
LIT25_04225	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_04230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LIT25_04235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LIT25_04240	COG0671	phosphoesterase, PA-phosphatase related
LIT25_04245	COG1295	ribonuclease BN
LIT25_04250	COG1329	Transcriptional regulator
LIT25_04255	COG0640	Transcriptional regulator
LIT25_04260	COG2233	PERMEase
LIT25_04265	COG0583	DNA-binding transcription factor activity
LIT25_04270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_04290	COG2318	DinB family
LIT25_04305	COG0628	permease
LIT25_04340	COG1764	response to oxidative stress
LIT25_04355	COG0668	transmembrane transport
LIT25_04360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LIT25_04365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_04380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LIT25_04385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LIT25_04400	COG1757	Na H antiporter
LIT25_04410	COG0589	response to stress
LIT25_04415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LIT25_04430	COG1132	(ABC) transporter
LIT25_04435	COG1132	(ABC) transporter
LIT25_04440	COG0702	epimerase
LIT25_04445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LIT25_04450	COG0765	amino acid transport
LIT25_04455	COG1126	abc transporter atp-binding protein
LIT25_04475	COG3842	ATPase activity
LIT25_04480	COG2508	Transcriptional regulator
LIT25_04500	COG0189	ligase activity
LIT25_04505	COG0189	ligase activity
LIT25_04510	COG4399	Belongs to the UPF0754 family
LIT25_04515	COG3679	Belongs to the UPF0342 family
LIT25_04520	COG0561	phosphatase activity
LIT25_04535	COG0561	phosphatase activity
LIT25_04540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LIT25_04545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LIT25_04600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LIT25_04600	COG1605	Chorismate mutase
LIT25_04640	COG1960	acyl-CoA dehydrogenase activity
LIT25_04645	COG1250	3-hydroxyacyl-CoA dehydrogenase
LIT25_04650	COG0183	Belongs to the thiolase family
LIT25_04655	COG1024	Enoyl-CoA hydratase
LIT25_04665	COG4152	abc transporter atp-binding protein
LIT25_04670	COG1668	transmembrane transport
LIT25_04675	COG0420	3'-5' exonuclease activity
LIT25_04680	COG4717	serine-type aminopeptidase activity
LIT25_04690	COG3481	metal-dependent phosphohydrolase, HD sub domain
LIT25_04700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LIT25_04730	COG1846	Transcriptional regulator
LIT25_04735	COG4980	gas vesicle protein
LIT25_04750	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LIT25_04755	COG0537	adenosine 5'-monophosphoramidase activity
LIT25_04760	COG1131	(ABC) transporter
LIT25_04765	COG4473	ABC transporter
LIT25_04775	COG1473	amidohydrolase
LIT25_04785	COG3069	C4-dicarboxylate transmembrane transporter activity
LIT25_04790	COG2329	Antibiotic biosynthesis monooxygenase
LIT25_04795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LIT25_04800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LIT25_04805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LIT25_04810	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LIT25_04815	COG1309	transcriptional regulator
LIT25_04820	COG1511	domain protein
LIT25_04825	COG1609	Transcriptional regulator
LIT25_04840	COG1234	tRNA 3'-trailer cleavage
LIT25_04845	COG0095	Lipoate-protein ligase
LIT25_04850	COG0318	PFAM AMP-dependent synthetase and ligase
LIT25_04855	COG1024	Enoyl-CoA hydratase
LIT25_04865	COG1396	sequence-specific DNA binding
LIT25_04870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LIT25_04880	COG0501	Belongs to the peptidase M48B family
LIT25_04885	COG2224	Isocitrate lyase
LIT25_04895	COG0383	alpha-mannosidase activity
LIT25_04910	COG5578	integral membrane protein
LIT25_04920	COG2972	Histidine kinase
LIT25_04925	COG4753	response regulator
LIT25_04925	COG2207	Transcriptional regulator
LIT25_04930	COG4209	transmembrane transport
LIT25_04935	COG0395	ABC-type sugar transport system, permease component
LIT25_04940	COG1653	transport
LIT25_04945	COG2723	6-phospho-beta-galactosidase activity
LIT25_04950	COG1940	carbohydrate kinase activity
LIT25_04965	COG1609	Transcriptional regulator
LIT25_04970	COG0673	inositol 2-dehydrogenase activity
LIT25_04985	COG3962	Belongs to the TPP enzyme family
LIT25_04990	COG1082	Xylose isomerase domain protein TIM barrel
LIT25_04995	COG3718	enzyme involved in inositol metabolism
LIT25_05000	COG2814	Major facilitator Superfamily
LIT25_05065	COG0398	Pfam SNARE associated Golgi protein
LIT25_05070	COG0681	Belongs to the peptidase S26 family
LIT25_05080	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LIT25_05085	COG1074	ATP-dependent DNA helicase activity
LIT25_05090	COG0420	3'-5' exonuclease activity
LIT25_05095	COG0419	ATPase involved in DNA repair
LIT25_05100	COG1403	HNH endonuclease
LIT25_05145	COG2311	Membrane
LIT25_05155	COG0179	Fumarylacetoacetate (FAA) hydrolase
LIT25_05160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LIT25_05175	COG0367	asparagine synthase
LIT25_05180	COG1464	Belongs to the NlpA lipoprotein family
LIT25_05185	COG0004	ammonium transporteR
LIT25_05190	COG0534	Mate efflux family protein
LIT25_05195	COG2207	Transcriptional regulator
LIT25_05195	COG1917	Cupin 2, conserved barrel domain protein
LIT25_05205	COG1113	amino acid transport
LIT25_05215	COG2182	Extracellular solute-binding protein
LIT25_05220	COG1175	transmembrane transport
LIT25_05225	COG3833	ABC-type maltose transport systems, permease component
LIT25_05230	COG0366	Alpha amylase catalytic
LIT25_05230	COG1874	Beta-galactosidase
LIT25_05260	COG1227	inorganic diphosphatase activity
LIT25_05275	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_05280	COG0646	methionine synthase
LIT25_05280	COG1410	methionine synthase
LIT25_05285	COG0646	methionine synthase
LIT25_05285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LIT25_05290	COG1666	GTP binding
LIT25_05295	COG2996	Protein conserved in bacteria
LIT25_05305	COG1307	EDD domain protein, DegV family
LIT25_05310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_05330	COG0561	phosphatase activity
LIT25_05335	COG1073	alpha beta
LIT25_05340	COG2151	metal-sulfur cluster biosynthetic enzyme
LIT25_05345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LIT25_05350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LIT25_05355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LIT25_05360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LIT25_05365	COG0505	Belongs to the CarA family
LIT25_05370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LIT25_05375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LIT25_05390	COG2267	carboxylic ester hydrolase activity
LIT25_05400	COG1744	ABC transporter substrate-binding protein PnrA-like
LIT25_05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LIT25_05425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LIT25_05430	COG5504	Zn-dependent protease
LIT25_05435	COG0444	Belongs to the ABC transporter superfamily
LIT25_05440	COG4608	Belongs to the ABC transporter superfamily
LIT25_05450	COG0601	transmembrane transport
LIT25_05455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LIT25_05475	COG0180	Tryptophanyl-tRNA synthetase
LIT25_05490	COG0601	transmembrane transport
LIT25_05495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LIT25_05500	COG0444	Belongs to the ABC transporter superfamily
LIT25_05505	COG4608	Belongs to the ABC transporter superfamily
LIT25_05520	COG0456	acetyltransferase
LIT25_05525	COG1393	Belongs to the ArsC family
LIT25_05530	COG0861	Integral membrane protein TerC family
LIT25_05535	COG4862	establishment of competence for transformation
LIT25_05540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LIT25_05545	COG4469	Competence protein
LIT25_05555	COG1164	Oligoendopeptidase f
LIT25_05565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LIT25_05570	COG2346	COG2346, Truncated hemoglobins
LIT25_05575	COG0741	lytic transglycosylase activity
LIT25_05580	COG4116	CYTH
LIT25_05590	COG2357	RelA SpoT domain protein
LIT25_05595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LIT25_05600	COG0564	pseudouridine synthase activity
LIT25_05605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LIT25_05610	COG0772	Belongs to the SEDS family
LIT25_05615	COG2239	Acts as a magnesium transporter
LIT25_05620	COG0475	glutathione-regulated potassium exporter activity
LIT25_05620	COG0569	domain protein
LIT25_05625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LIT25_05630	COG0352	thiamine-phosphate diphosphorylase activity
LIT25_05645	COG2022	thiamine diphosphate biosynthetic process
LIT25_05650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LIT25_05655	COG2733	membrane
LIT25_05660	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LIT25_05685	COG3546	catalase activity
LIT25_05700	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LIT25_05705	COG0438	transferase activity, transferring glycosyl groups
LIT25_05710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LIT25_05720	COG0438	transferase activity, transferring glycosyl groups
LIT25_05725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LIT25_05730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LIT25_05735	COG0438	transferase activity, transferring glycosyl groups
LIT25_05790	COG0210	DNA helicase
LIT25_05805	COG2323	membrane
LIT25_05810	COG2153	protein acetylation
LIT25_05815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LIT25_05820	COG2382	esterase
LIT25_05835	COG0626	cystathionine gamma-synthase activity
LIT25_05840	COG0626	cystathionine gamma-synthase activity
LIT25_05875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LIT25_05880	COG4977	sequence-specific DNA binding
LIT25_05910	COG0588	phosphoglycerate mutase activity
LIT25_05915	COG2207	Transcriptional regulator
LIT25_05915	COG3708	Transcriptional regulator
LIT25_05925	COG2207	Transcriptional regulator
LIT25_05925	COG3708	Transcriptional regulator
LIT25_05930	COG0586	Pfam SNARE associated Golgi protein
LIT25_05955	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LIT25_05960	COG0772	Belongs to the SEDS family
LIT25_05965	COG0697	spore germination
LIT25_05990	COG3739	integral membrane protein
LIT25_05995	COG2514	catechol 2,3-dioxygenase activity
LIT25_06005	COG2318	DinB family
LIT25_06010	COG3239	Fatty acid desaturase
LIT25_06015	COG4585	Histidine kinase
LIT25_06020	COG2197	response regulator
LIT25_06065	COG2271	Major facilitator Superfamily
LIT25_06085	COG2211	Major facilitator Superfamily
LIT25_06105	COG1131	(ABC) transporter
LIT25_06125	COG1607	acyl-coa hydrolase
LIT25_06140	COG0531	amino acid
LIT25_06145	COG1846	Transcriptional regulator
LIT25_06150	COG1033	growth of symbiont in host cell
LIT25_06150	COG2409	Drug exporters of the RND superfamily
LIT25_06155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_06160	COG0640	Transcriptional regulator
LIT25_06165	COG0346	lactoylglutathione lyase activity
LIT25_06175	COG0604	alcohol dehydrogenase
LIT25_06215	COG0346	lactoylglutathione lyase activity
LIT25_06225	COG0640	Transcriptional regulator
LIT25_06235	COG5434	Belongs to the glycosyl hydrolase 28 family
LIT25_06235	COG4632	Exopolysaccharide biosynthesis protein
LIT25_06240	COG0346	lactoylglutathione lyase activity
LIT25_06245	COG1473	amidohydrolase
LIT25_06250	COG1757	Na H antiporter
LIT25_06285	COG0281	malic enzyme
LIT25_06290	COG1027	Aspartate ammonia-lyase
LIT25_06300	COG4191	Histidine kinase
LIT25_06305	COG0784	Response regulator, receiver
LIT25_06310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LIT25_06315	COG0745	RESPONSE REGULATOR receiver
LIT25_06350	COG0861	Integral membrane protein TerC family
LIT25_06365	COG1126	abc transporter atp-binding protein
LIT25_06370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LIT25_06375	COG0765	amino acid transport
LIT25_06380	COG0765	amino acid transport
LIT25_06405	COG5577	PFAM Coat F domain
LIT25_06425	COG3832	glyoxalase III activity
LIT25_06430	COG2358	TRAP transporter, solute receptor (TAXI family
LIT25_06475	COG1404	Belongs to the peptidase S8 family
LIT25_06495	COG2608	mercury ion transmembrane transporter activity
LIT25_06500	COG2217	Heavy metal translocating P-type atpase
LIT25_06550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LIT25_06560	COG0805	protein transport
LIT25_06565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_06575	COG1349	DNA-binding transcription factor activity
LIT25_06585	COG1609	Transcriptional regulator
LIT25_06590	COG1904	glucuronate isomerase
LIT25_06595	COG1312	Catalyzes the dehydration of D-mannonate
LIT25_06600	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_06605	COG1619	proteins homologs of microcin C7 resistance protein MccF
LIT25_06615	COG1587	Uroporphyrinogen-III synthase
LIT25_06620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LIT25_06625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LIT25_06640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LIT25_06645	COG1088	dTDP-glucose 4,6-dehydratase activity
LIT25_06650	COG1091	dTDP-4-dehydrorhamnose reductase activity
LIT25_06655	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LIT25_06660	COG1216	Glycosyl transferase, family 2
LIT25_06670	COG1086	Polysaccharide biosynthesis protein
LIT25_06675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LIT25_06680	COG2089	acid synthase
LIT25_06685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LIT25_06695	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_06705	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_06735	COG0463	Glycosyl transferase, family 2
LIT25_06755	COG1733	regulation of RNA biosynthetic process
LIT25_06760	COG2814	Major facilitator Superfamily
LIT25_06765	COG0656	L-ascorbic acid biosynthetic process
LIT25_06790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LIT25_06795	COG3813	Protein conserved in bacteria
LIT25_06815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LIT25_06860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_06890	COG5444	nuclease activity
LIT25_06900	COG5444	nuclease activity
LIT25_06915	COG2814	Major facilitator Superfamily
LIT25_06925	COG1113	amino acid transport
LIT25_06940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LIT25_06945	COG1834	amidinotransferase
LIT25_06955	COG3403	YqcI/YcgG family
LIT25_06960	COG1280	lysine exporter protein (LysE YggA)
LIT25_06970	COG0583	DNA-binding transcription factor activity
LIT25_06975	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
LIT25_07005	COG3622	Belongs to the hyi family
LIT25_07010	COG2188	Transcriptional regulator
LIT25_07020	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LIT25_07025	COG3639	organic phosphonate transmembrane transporter activity
LIT25_07030	COG3639	organic phosphonate transmembrane transporter activity
LIT25_07050	COG3627	carbon phosphorus lyase activity
LIT25_07055	COG4107	phosphonate C-P lyase system protein PhnK
LIT25_07060	COG3454	Phosphonate metabolism
LIT25_07070	COG4778	phosphonate C-P lyase system protein PhnL
LIT25_07075	COG0613	PHP domain protein
LIT25_07090	COG0477	Major facilitator Superfamily
LIT25_07120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_07135	COG2002	toxin-antitoxin pair type II binding
LIT25_07145	COG2801	Transposase and inactivated derivatives
LIT25_07150	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LIT25_07165	COG2124	cytochrome p450
LIT25_07210	COG1404	Belongs to the peptidase S8 family
LIT25_07235	COG1595	DNA-templated transcription, initiation
LIT25_07280	COG1131	(ABC) transporter
LIT25_07285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LIT25_07290	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_07310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LIT25_07315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LIT25_07320	COG2706	6-phosphogluconolactonase activity
LIT25_07330	COG0765	amino acid transport
LIT25_07335	COG1126	abc transporter atp-binding protein
LIT25_07340	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_07350	COG2322	membrane
LIT25_07360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LIT25_07365	COG1595	DNA-templated transcription, initiation
LIT25_07375	COG2362	D-Aminopeptidase
LIT25_07380	COG0601	transmembrane transport
LIT25_07385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LIT25_07390	COG0444	Belongs to the ABC transporter superfamily
LIT25_07395	COG4166	transmembrane transport
LIT25_07400	COG1619	proteins homologs of microcin C7 resistance protein MccF
LIT25_07405	COG4948	Mandelate Racemase Muconate Lactonizing
LIT25_07410	COG0791	NLP P60 protein
LIT25_07415	COG4608	Belongs to the ABC transporter superfamily
LIT25_07430	COG1388	LysM domain
LIT25_07445	COG0745	RESPONSE REGULATOR receiver
LIT25_07450	COG0666	response to abiotic stimulus
LIT25_07470	COG2002	toxin-antitoxin pair type II binding
LIT25_07480	COG1376	ErfK ybiS ycfS ynhG family protein
LIT25_07490	COG2801	Transposase and inactivated derivatives
LIT25_07525	COG2002	toxin-antitoxin pair type II binding
LIT25_07540	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_07555	COG3540	Alkaline phosphatase
LIT25_07565	COG1175	transmembrane transport
LIT25_07580	COG1796	DNA polymerase
LIT25_07580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LIT25_07590	COG1349	DNA-binding transcription factor activity
LIT25_07600	COG3540	Alkaline phosphatase
LIT25_07630	COG2801	Transposase and inactivated derivatives
LIT25_07660	COG1116	anion transmembrane transporter activity
LIT25_07665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LIT25_07740	COG1231	oxidoreductase activity
LIT25_07745	COG1404	Belongs to the peptidase S8 family
LIT25_07785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LIT25_07790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LIT25_07800	COG1136	(ABC) transporter
LIT25_07805	COG0577	efflux transmembrane transporter activity
LIT25_07810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LIT25_07835	COG0596	Alpha beta hydrolase
LIT25_07860	COG4191	Histidine kinase
LIT25_07865	COG1834	amidinotransferase
LIT25_07870	COG1609	Transcriptional regulator
LIT25_07880	COG1363	Peptidase, m42
LIT25_07885	COG1404	Belongs to the peptidase S8 family
LIT25_07900	COG1125	glycine betaine transport
LIT25_07900	COG0517	IMP dehydrogenase activity
LIT25_07905	COG1174	glycine betaine transport
LIT25_07910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_07910	COG3711	transcriptional antiterminator
LIT25_07915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LIT25_07915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LIT25_07915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_07920	COG1482	cell wall glycoprotein biosynthetic process
LIT25_07955	COG1752	Esterase of the alpha-beta hydrolase superfamily
LIT25_07965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LIT25_07975	COG1126	abc transporter atp-binding protein
LIT25_07980	COG0765	amino acid transport
LIT25_07985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LIT25_08000	COG3871	stress protein (general stress protein 26)
LIT25_08005	COG0277	FAD linked oxidase domain protein
LIT25_08010	COG2271	Major facilitator Superfamily
LIT25_08025	COG0405	Gamma-glutamyltransferase
LIT25_08030	COG1263	PTS System
LIT25_08030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_08035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LIT25_08040	COG0363	glucosamine-6-phosphate deaminase activity
LIT25_08045	COG2188	Transcriptional regulator
LIT25_08050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LIT25_08060	COG1278	Cold shock
LIT25_08065	COG2824	Alkylphosphonate utilization operon protein PhnA
LIT25_08070	COG0723	plastoquinol--plastocyanin reductase activity
LIT25_08070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LIT25_08075	COG0488	(ABC) transporter
LIT25_08085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LIT25_08090	COG4120	Belongs to the binding-protein-dependent transport system permease family
LIT25_08125	COG1404	Belongs to the peptidase S8 family
LIT25_08145	COG2310	stress, protein
LIT25_08150	COG2304	oxidoreductase activity
LIT25_08155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LIT25_08160	COG1737	Transcriptional regulator
LIT25_08165	COG1263	PTS System
LIT25_08165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_08175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LIT25_08180	COG1472	Belongs to the glycosyl hydrolase 3 family
LIT25_08195	COG0673	inositol 2-dehydrogenase activity
LIT25_08205	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_08210	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_08215	COG0745	RESPONSE REGULATOR receiver
LIT25_08220	COG3850	Histidine kinase
LIT25_08220	COG5002	protein histidine kinase activity
LIT25_08225	COG3212	peptidase
LIT25_08240	COG2268	Band 7 protein
LIT25_08245	COG1585	Membrane protein implicated in regulation of membrane protease activity
LIT25_08250	COG3835	regulator
LIT25_08270	COG1929	Belongs to the glycerate kinase type-1 family
LIT25_08280	COG0745	RESPONSE REGULATOR receiver
LIT25_08315	COG1595	DNA-templated transcription, initiation
LIT25_08320	COG0673	inositol 2-dehydrogenase activity
LIT25_08325	COG0673	inositol 2-dehydrogenase activity
LIT25_08330	COG1082	Xylose isomerase domain protein TIM barrel
LIT25_08365	COG1846	Transcriptional regulator
LIT25_08370	COG1764	response to oxidative stress
LIT25_08400	COG0789	Transcriptional regulator
LIT25_08420	COG0746	molybdenum cofactor guanylyltransferase activity
LIT25_08425	COG1846	Transcriptional regulator
LIT25_08435	COG1793	dna ligase
LIT25_08435	COG3285	dna ligase
LIT25_08440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LIT25_08445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LIT25_08460	COG0586	Pfam SNARE associated Golgi protein
LIT25_08465	COG0861	Integral membrane protein TerC family
LIT25_08470	COG1191	sigma factor activity
LIT25_08495	COG0501	Belongs to the peptidase M48B family
LIT25_08500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LIT25_08505	COG0768	penicillin binding
LIT25_08515	COG4085	toxin activity
LIT25_08515	COG0737	Belongs to the 5'-nucleotidase family
LIT25_08515	COG1525	nuclease
LIT25_08545	COG3594	Acyltransferase
LIT25_08550	COG5002	protein histidine kinase activity
LIT25_08555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LIT25_08580	COG1129	ABC transporter
LIT25_08585	COG1879	ABC-type sugar transport system periplasmic component
LIT25_08590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LIT25_08595	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LIT25_08605	COG0436	Aminotransferase
LIT25_08610	COG1850	ribulose-bisphosphate carboxylase activity
LIT25_08615	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
LIT25_08620	COG0235	Class ii aldolase
LIT25_08625	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LIT25_08650	COG0667	Aldo Keto reductase
LIT25_08655	COG3852	Histidine kinase
LIT25_08660	COG0737	Belongs to the 5'-nucleotidase family
LIT25_08665	COG1846	Transcriptional regulator
LIT25_08675	COG1360	Flagellar Motor Protein
LIT25_08680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LIT25_08695	COG0542	response to heat
LIT25_08700	COG3949	Membrane
LIT25_08705	COG1253	flavin adenine dinucleotide binding
LIT25_08725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LIT25_08730	COG0720	synthase
LIT25_08735	COG0602	queuosine metabolic process
LIT25_08740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LIT25_08745	COG1278	Cold shock
LIT25_08765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LIT25_08780	COG2323	membrane
LIT25_08785	COG0671	phosphoesterase, PA-phosphatase related
LIT25_08805	COG2135	peptidase activity
LIT25_08810	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LIT25_08815	COG3583	domain protein
LIT25_08815	COG3584	3D domain protein
LIT25_08820	COG1214	PFAM Peptidase M22, glycoprotease
LIT25_08820	COG0456	acetyltransferase
LIT25_08825	COG4873	Protein conserved in bacteria
LIT25_08830	COG4667	esterase of the alpha-beta hydrolase superfamily
LIT25_08850	COG3773	Cell wall hydrolase
LIT25_08870	COG2244	polysaccharide biosynthetic process
LIT25_08875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LIT25_08910	COG2217	Heavy metal translocating P-type atpase
LIT25_08930	COG0006	proline dipeptidase activity
LIT25_08935	COG1525	nuclease
LIT25_08965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LIT25_08990	COG0561	phosphatase activity
LIT25_09005	COG3711	transcriptional antiterminator
LIT25_09010	COG1263	PTS System
LIT25_09010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_09010	COG2190	(PTS) system
LIT25_09015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_09020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LIT25_09045	COG2084	Dehydrogenase
LIT25_09050	COG0456	acetyltransferase
LIT25_09055	COG2340	Cysteine-rich secretory protein family
LIT25_09060	COG0768	penicillin binding
LIT25_09075	COG4191	Histidine kinase
LIT25_09080	COG0436	Aminotransferase
LIT25_09085	COG0598	Magnesium transport protein CorA
LIT25_09110	COG2205	protein histidine kinase activity
LIT25_09125	COG2814	Major facilitator Superfamily
LIT25_09145	COG3437	response regulator, receiver
LIT25_09145	COG2770	Histidine kinase
LIT25_09155	COG2814	Major facilitator Superfamily
LIT25_09160	COG1376	ErfK ybiS ycfS ynhG family protein
LIT25_09175	COG2200	EAL domain
LIT25_09175	COG2199	diguanylate cyclase activity
LIT25_09175	COG2202	Pas domain
LIT25_09180	COG1408	metallophosphoesterase
LIT25_09185	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_09190	COG2200	EAL domain
LIT25_09220	COG4703	Protein of unknown function (DUF1797)
LIT25_09230	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
LIT25_09245	COG0517	IMP dehydrogenase activity
LIT25_09250	COG0477	Major facilitator Superfamily
LIT25_09265	COG0583	DNA-binding transcription factor activity
LIT25_09270	COG0716	FMN binding
LIT25_09280	COG0716	FMN binding
LIT25_09290	COG1473	amidohydrolase
LIT25_09305	COG0450	alkyl hydroperoxide reductase
LIT25_09310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_09315	COG0604	alcohol dehydrogenase
LIT25_09320	COG1278	Cold shock
LIT25_09345	COG0493	'glutamate synthase
LIT25_09350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LIT25_09350	COG0167	dihydroorotate dehydrogenase activity
LIT25_09370	COG3835	regulator
LIT25_09375	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_09380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LIT25_09385	COG1349	DNA-binding transcription factor activity
LIT25_09390	COG0110	maltose O-acetyltransferase activity
LIT25_09405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LIT25_09410	COG0655	NAD(P)H dehydrogenase (quinone) activity
LIT25_09415	COG1132	(ABC) transporter
LIT25_09420	COG1132	(ABC) transporter
LIT25_09430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIT25_09435	COG1136	(ABC) transporter
LIT25_09440	COG0577	efflux transmembrane transporter activity
LIT25_09455	COG0681	Belongs to the peptidase S26 family
LIT25_09475	COG0488	(ABC) transporter
LIT25_09480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LIT25_09490	COG1307	EDD domain protein, DegV family
LIT25_09495	COG2309	aminopeptidase activity
LIT25_09500	COG1960	acyl-CoA dehydrogenase activity
LIT25_09510	COG0488	(ABC) transporter
LIT25_09515	COG2720	vancomycin resistance protein
LIT25_09520	COG1077	Cell shape determining protein MreB Mrl
LIT25_09525	COG1607	acyl-coa hydrolase
LIT25_09530	COG4637	Psort location Cytoplasmic, score
LIT25_09535	COG3852	Histidine kinase
LIT25_09540	COG2105	PFAM AIG2 family protein
LIT25_09540	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LIT25_09545	COG1271	oxidase subunit
LIT25_09550	COG1294	oxidase, subunit
LIT25_09555	COG0569	domain protein
LIT25_09560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LIT25_09570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LIT25_09580	COG0561	phosphatase activity
LIT25_09585	COG0242	peptide deformylase activity
LIT25_09600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LIT25_09605	COG0022	dehydrogenase e1 component
LIT25_09610	COG0508	dehydrogenase complex catalyzes the overall conversion of
LIT25_09615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LIT25_09640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_09670	COG1982	Orn Lys Arg decarboxylase major
LIT25_09675	COG1960	acyl-CoA dehydrogenase activity
LIT25_09680	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_09690	COG1309	transcriptional regulator
LIT25_09700	COG1024	Enoyl-CoA hydratase
LIT25_09720	COG4221	oxidoreductase activity
LIT25_09725	COG1024	Enoyl-CoA hydratase
LIT25_09735	COG0318	PFAM AMP-dependent synthetase and ligase
LIT25_09750	COG4476	Belongs to the UPF0223 family
LIT25_09765	COG0483	inositol monophosphate 1-phosphatase activity
LIT25_09780	COG1217	gtp-binding protein TYPA
LIT25_09800	COG4896	Protein conserved in bacteria
LIT25_09815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LIT25_09820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LIT25_09825	COG2066	Belongs to the glutaminase family
LIT25_09830	COG4838	Belongs to the UPF0358 family
LIT25_09835	COG0772	Belongs to the SEDS family
LIT25_09840	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LIT25_09845	COG1612	heme a metabolic process
LIT25_09855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LIT25_09855	COG2010	Cytochrome c
LIT25_09860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LIT25_09865	COG1845	cytochrome c oxidase, subunit III
LIT25_09875	COG3336	cytochrome c oxidase
LIT25_09895	COG0628	permease
LIT25_09905	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
LIT25_09910	COG2340	Cysteine-rich secretory protein family
LIT25_09935	COG3679	Belongs to the UPF0342 family
LIT25_09955	COG0742	ribosomal rna small subunit methyltransferase
LIT25_09960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LIT25_09965	COG3314	Sporulation integral membrane protein YlbJ
LIT25_09970	COG1752	Esterase of the alpha-beta hydrolase superfamily
LIT25_09975	COG3480	Lon protease (S16) C-terminal proteolytic domain
LIT25_09980	COG1323	Belongs to the UPF0348 family
LIT25_09985	COG1399	metal-binding, possibly nucleic acid-binding protein
LIT25_09990	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LIT25_09995	COG1024	Enoyl-CoA hydratase
LIT25_10005	COG0454	-acetyltransferase
LIT25_10010	COG0439	Biotin carboxylase
LIT25_10015	COG0511	ligase activity, forming carbon-carbon bonds
LIT25_10020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LIT25_10025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LIT25_10035	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LIT25_10040	COG2001	Belongs to the MraZ family
LIT25_10045	COG0275	rRNA processing
LIT25_10050	COG4839	cell division protein FtsL
LIT25_10055	COG0768	penicillin binding
LIT25_10060	COG0768	penicillin binding
LIT25_10065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LIT25_10070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LIT25_10075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LIT25_10080	COG0772	Belongs to the SEDS family
LIT25_10090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LIT25_10095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LIT25_10100	COG3879	Bacterial protein of unknown function (DUF881)
LIT25_10105	COG3879	Bacterial protein of unknown function (DUF881)
LIT25_10110	COG3856	small basic protein
LIT25_10115	COG0849	cell division
LIT25_10120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LIT25_10125	COG1404	Belongs to the peptidase S8 family
LIT25_10125	COG4412	M6 family metalloprotease domain protein
LIT25_10135	COG1191	sigma factor activity
LIT25_10140	COG1191	sigma factor activity
LIT25_10145	COG3689	TIGRFAM TIGR03943 family protein
LIT25_10150	COG0701	Predicted permease
LIT25_10155	COG1873	PFAM PRC-barrel domain
LIT25_10160	COG1496	oxidoreductase activity
LIT25_10165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LIT25_10170	COG1799	cell septum assembly
LIT25_10175	COG0762	integral membrane protein
LIT25_10180	COG2302	S4 RNA-binding domain
LIT25_10185	COG3599	regulation of cell shape
LIT25_10190	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LIT25_10195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LIT25_10205	COG0564	pseudouridine synthase activity
LIT25_10210	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LIT25_10225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LIT25_10230	COG0505	Belongs to the CarA family
LIT25_10235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LIT25_10245	COG0167	dihydroorotate dehydrogenase activity
LIT25_10250	COG0284	orotidine-5'-phosphate decarboxylase activity
LIT25_10270	COG0306	phosphate transporter
LIT25_10280	COG0529	Catalyzes the synthesis of activated sulfate
LIT25_10290	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
LIT25_10295	COG1648	precorrin-2 dehydrogenase activity
LIT25_10305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LIT25_10310	COG1561	YicC-like family, N-terminal region
LIT25_10320	COG0194	GDP metabolic process
LIT25_10325	COG1758	RNA polymerase activity
LIT25_10330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LIT25_10335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LIT25_10345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LIT25_10350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LIT25_10350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LIT25_10360	COG0631	protein serine/threonine phosphatase activity
LIT25_10365	COG0515	serine threonine protein kinase
LIT25_10365	COG2815	serine threonine protein kinase
LIT25_10370	COG1162	GTPase activity
LIT25_10375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LIT25_10380	COG1564	THIamine pyrophosphokinase
LIT25_10395	COG1302	Protein conserved in bacteria
LIT25_10400	COG1461	Dihydroxyacetone kinase
LIT25_10405	COG1760	l-serine dehydratase
LIT25_10410	COG1760	l-serine dehydratase
LIT25_10415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LIT25_10420	COG1349	DNA-binding transcription factor activity
LIT25_10425	COG0416	fatty acid biosynthetic process
LIT25_10430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LIT25_10435	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_10440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LIT25_10450	COG1196	nuclear chromosome segregation
LIT25_10455	COG0552	protein localization to endoplasmic reticulum
LIT25_10465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LIT25_10475	COG1837	Belongs to the UPF0109 family
LIT25_10485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LIT25_10490	COG0336	Belongs to the RNA methyltransferase TrmD family
LIT25_10495	COG0335	large ribosomal subunit rRNA binding
LIT25_10530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LIT25_10535	COG0758	DNA mediated transformation
LIT25_10540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LIT25_10545	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LIT25_10550	COG4974	Belongs to the 'phage' integrase family
LIT25_10560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LIT25_10565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LIT25_10570	COG1815	bacterial-type flagellum-dependent cell motility
LIT25_10575	COG1558	bacterial-type flagellum-dependent cell motility
LIT25_10580	COG1677	Flagellar hook-basal body complex protein FliE
LIT25_10585	COG1766	The M ring may be actively involved in energy transduction
LIT25_10590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LIT25_10600	COG1157	protein secretion by the type III secretion system
LIT25_10605	COG2882	bacterial-type flagellum organization
LIT25_10615	COG3144	bacterial-type flagellum assembly
LIT25_10620	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LIT25_10625	COG4786	Flagellar basal body rod
LIT25_10630	COG1582	Flagellar protein (FlbD)
LIT25_10635	COG1580	Controls the rotational direction of flagella during chemotaxis
LIT25_10640	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LIT25_10645	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LIT25_10645	COG1776	CheC inhibitor of MCP methylation
LIT25_10650	COG2201	protein-glutamate methylesterase activity
LIT25_10655	COG3190	flagellar
LIT25_10660	COG1338	Plays a role in the flagellum-specific transport system
LIT25_10665	COG1987	bacterial-type flagellum assembly
LIT25_10670	COG1684	flagellar biosynthetic protein fliR
LIT25_10675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LIT25_10680	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LIT25_10685	COG1419	protein localization to endoplasmic reticulum
LIT25_10700	COG0052	Belongs to the universal ribosomal protein uS2 family
LIT25_10710	COG0528	UMP kinase activity
LIT25_10715	COG0233	cytoplasmic translational termination
LIT25_10720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LIT25_10725	COG4589	Belongs to the CDS family
LIT25_10730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LIT25_10735	COG0750	zinc metalloprotease
LIT25_10740	COG0442	prolyl-tRNA aminoacylation
LIT25_10745	COG2176	DNA-directed DNA polymerase activity
LIT25_10750	COG0779	Required for maturation of 30S ribosomal subunits
LIT25_10755	COG0195	Participates in both transcription termination and antitermination
LIT25_10760	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LIT25_10765	COG1358	cellular component organization or biogenesis
LIT25_10775	COG1550	Protein conserved in bacteria
LIT25_10780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LIT25_10785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LIT25_10790	COG0196	riboflavin kinase activity
LIT25_10800	COG1185	polyribonucleotide nucleotidyltransferase activity
LIT25_10805	COG0726	polysaccharide deacetylase
LIT25_10810	COG0612	Peptidase, M16
LIT25_10815	COG1873	PFAM PRC-barrel domain
LIT25_10820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LIT25_10825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LIT25_10830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LIT25_10835	COG0527	aspartate kinase activity
LIT25_10845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LIT25_10850	COG0740	serine-type endopeptidase activity
LIT25_10860	COG1674	ftsk spoiiie
LIT25_10860	COG4980	gas vesicle protein
LIT25_10865	COG2188	Transcriptional regulator
LIT25_10870	COG1744	ABC transporter substrate-binding protein PnrA-like
LIT25_10875	COG3845	ABC transporter
LIT25_10880	COG4603	Belongs to the binding-protein-dependent transport system permease family
LIT25_10885	COG1079	Belongs to the binding-protein-dependent transport system permease family
LIT25_10895	COG0612	Peptidase, M16
LIT25_10900	COG0612	Peptidase, M16
LIT25_10905	COG0300	oxidoreductase activity
LIT25_10920	COG1426	Protein conserved in bacteria
LIT25_10925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LIT25_10930	COG1058	Belongs to the CinA family
LIT25_10930	COG1546	Belongs to the CinA family
LIT25_10935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LIT25_10940	COG1418	mRNA catabolic process
LIT25_10945	COG1692	metallophosphoesterase
LIT25_10950	COG2359	stage V sporulation protein S
LIT25_10965	COG1013	pyruvate-flavodoxin oxidoreductase activity
LIT25_10970	COG1063	alcohol dehydrogenase
LIT25_10975	COG0156	8-amino-7-oxononanoate synthase activity
LIT25_10980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LIT25_10985	COG4550	Control of competence regulator ComK, YlbF/YmcA
LIT25_11000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LIT25_11005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LIT25_11030	COG0583	DNA-binding transcription factor activity
LIT25_11035	COG0318	PFAM AMP-dependent synthetase and ligase
LIT25_11045	COG2271	Major facilitator Superfamily
LIT25_11055	COG0657	acetylesterase activity
LIT25_11060	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_11070	COG2271	Major facilitator Superfamily
LIT25_11085	COG0583	DNA-binding transcription factor activity
LIT25_11090	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_11100	COG0300	oxidoreductase activity
LIT25_11105	COG1960	acyl-CoA dehydrogenase activity
LIT25_11115	COG2086	electron transfer activity
LIT25_11120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LIT25_11125	COG0439	Biotin carboxylase
LIT25_11130	COG0511	ligase activity, forming carbon-carbon bonds
LIT25_11135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LIT25_11145	COG2801	Transposase and inactivated derivatives
LIT25_11150	COG3655	Transcriptional regulator
LIT25_11180	COG1280	lysine exporter protein (LysE YggA)
LIT25_11190	COG1994	Peptidase M50
LIT25_11200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LIT25_11205	COG1923	regulation of RNA biosynthetic process
LIT25_11210	COG0464	growth
LIT25_11215	COG2860	membrane
LIT25_11220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LIT25_11225	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LIT25_11230	COG0789	Transcriptional regulator
LIT25_11235	COG0174	glutamine synthetase
LIT25_11240	COG0791	NLP P60 protein
LIT25_11240	COG0741	lytic transglycosylase activity
LIT25_11275	COG1793	dna ligase
LIT25_11290	COG1309	transcriptional regulator
LIT25_11310	COG2801	Transposase and inactivated derivatives
LIT25_11345	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_11350	COG0789	Transcriptional regulator
LIT25_11355	COG0702	epimerase
LIT25_11360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LIT25_11390	COG2832	Protein of unknown function (DUF454)
LIT25_11415	COG2207	Transcriptional regulator
LIT25_11485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LIT25_11500	COG2972	Histidine kinase
LIT25_11505	COG2207	Transcriptional regulator
LIT25_11505	COG4753	response regulator
LIT25_11515	COG1175	transmembrane transport
LIT25_11520	COG0395	ABC-type sugar transport system, permease component
LIT25_11530	COG3250	beta-galactosidase activity
LIT25_11540	COG2329	Antibiotic biosynthesis monooxygenase
LIT25_11585	COG1609	Transcriptional regulator
LIT25_11590	COG0561	phosphatase activity
LIT25_11595	COG1694	Mazg nucleotide pyrophosphohydrolase
LIT25_11610	COG2801	Transposase and inactivated derivatives
LIT25_11615	COG1802	Transcriptional regulator
LIT25_11620	COG1114	Component of the transport system for branched-chain amino acids
LIT25_11655	COG2329	Antibiotic biosynthesis monooxygenase
LIT25_11660	COG2188	Transcriptional regulator
LIT25_11670	COG1175	transmembrane transport
LIT25_11675	COG3833	ABC-type maltose transport systems, permease component
LIT25_11680	COG3842	ATPase activity
LIT25_11685	COG0561	phosphatase activity
LIT25_11695	COG0534	Mate efflux family protein
LIT25_11710	COG0183	Belongs to the thiolase family
LIT25_11720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIT25_11725	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIT25_11735	COG0318	PFAM AMP-dependent synthetase and ligase
LIT25_11740	COG0006	proline dipeptidase activity
LIT25_11745	COG1309	transcriptional regulator
LIT25_11765	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_11770	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LIT25_11785	COG1309	transcriptional regulator
LIT25_11815	COG2814	Major facilitator Superfamily
LIT25_11820	COG1809	phosphosulfolactate synthase activity
LIT25_11825	COG0406	alpha-ribazole phosphatase activity
LIT25_11830	COG0697	spore germination
LIT25_11835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_11850	COG1657	PFAM Prenyltransferase squalene oxidase
LIT25_11900	COG2132	Multicopper oxidase
LIT25_11910	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LIT25_11945	COG0640	Transcriptional regulator
LIT25_11990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LIT25_11995	COG1408	metallophosphoesterase
LIT25_12000	COG0726	polysaccharide deacetylase
LIT25_12005	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LIT25_12025	COG0582	viral genome integration into host DNA
LIT25_12040	COG3048	D-serine ammonia-lyase activity
LIT25_12050	COG2801	Transposase and inactivated derivatives
LIT25_12075	COG1309	transcriptional regulator
LIT25_12080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LIT25_12085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LIT25_12090	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_12095	COG0183	Belongs to the thiolase family
LIT25_12150	COG4221	oxidoreductase activity
LIT25_12185	COG0673	inositol 2-dehydrogenase activity
LIT25_12200	COG0673	inositol 2-dehydrogenase activity
LIT25_12215	COG1737	Transcriptional regulator
LIT25_12225	COG1175	transmembrane transport
LIT25_12230	COG0395	ABC-type sugar transport system, permease component
LIT25_12240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LIT25_12245	COG0673	inositol 2-dehydrogenase activity
LIT25_12250	COG1940	carbohydrate kinase activity
LIT25_12260	COG2188	Transcriptional regulator
LIT25_12285	COG3537	Alpha-1,2-mannosidase
LIT25_12310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_12325	COG1454	alcohol dehydrogenase
LIT25_12335	COG2072	flavoprotein involved in K transport
LIT25_12340	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_12345	COG2271	Major facilitator Superfamily
LIT25_12350	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_12365	COG1309	transcriptional regulator
LIT25_12375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LIT25_12380	COG1388	LysM domain
LIT25_12385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LIT25_12390	COG4224	UPF0291 protein
LIT25_12395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LIT25_12405	COG3763	UPF0154 protein
LIT25_12420	COG4974	Belongs to the 'phage' integrase family
LIT25_12450	COG0785	Cytochrome C biogenesis protein
LIT25_12460	COG4846	Membrane protein involved in cytochrome C biogenesis
LIT25_12485	COG0071	Belongs to the small heat shock protein (HSP20) family
LIT25_12505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LIT25_12510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_12530	COG0824	Thioesterase
LIT25_12540	COG4841	protein insertion into membrane
LIT25_12545	COG2843	Capsule synthesis protein
LIT25_12550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LIT25_12555	COG1832	CoA-binding protein
LIT25_12570	COG0187	DNA topoisomerase II activity
LIT25_12575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LIT25_12585	COG1115	amino acid carrier protein
LIT25_12600	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_12605	COG1268	BioY protein
LIT25_12610	COG0318	PFAM AMP-dependent synthetase and ligase
LIT25_12615	COG0183	Belongs to the thiolase family
LIT25_12625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LIT25_12640	COG1131	(ABC) transporter
LIT25_12685	COG3541	Predicted nucleotidyltransferase
LIT25_12695	COG0640	Transcriptional regulator
LIT25_12715	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LIT25_12725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LIT25_12730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LIT25_12735	COG1120	ATPase activity
LIT25_12740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LIT25_12745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LIT25_12750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LIT25_12755	COG1492	cobalamin metabolic process
LIT25_12760	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LIT25_12795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LIT25_12805	COG4589	Belongs to the CDS family
LIT25_12810	COG3906	Belongs to the UPF0473 family
LIT25_12820	COG0322	excinuclease ABC activity
LIT25_12830	COG5553	Cysteine dioxygenase type I
LIT25_12865	COG3764	Sortase (surface protein transpeptidase)
LIT25_12900	COG0463	Glycosyl transferase, family 2
LIT25_12920	COG2427	Protein of unknown function (DUF1641)
LIT25_12925	COG3383	formate dehydrogenase (NAD+) activity
LIT25_12930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LIT25_12935	COG0314	molybdopterin synthase activity
LIT25_12940	COG1763	Mo-molybdopterin cofactor biosynthetic process
LIT25_12945	COG0303	'Molybdopterin
LIT25_12955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LIT25_12960	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LIT25_12980	COG1193	negative regulation of DNA recombination
LIT25_12985	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LIT25_12990	COG1984	allophanate hydrolase subunit 2
LIT25_12995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LIT25_13000	COG1914	H( )-stimulated, divalent metal cation uptake system
LIT25_13005	COG1556	Lactate utilization protein
LIT25_13010	COG1139	Iron-sulfur cluster binding protein
LIT25_13015	COG0247	lactate metabolic process
LIT25_13020	COG0247	lactate metabolic process
LIT25_13025	COG0277	FAD linked oxidase domain protein
LIT25_13030	COG3835	regulator
LIT25_13035	COG0693	protein deglycase activity
LIT25_13060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LIT25_13065	COG2169	Transcriptional regulator
LIT25_13070	COG1620	l-lactate permease
LIT25_13075	COG1414	Transcriptional regulator
LIT25_13080	COG0179	Fumarylacetoacetate (FAA) hydrolase
LIT25_13085	COG0281	malic enzyme
LIT25_13090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LIT25_13095	COG0277	FAD linked oxidase domain protein
LIT25_13100	COG0247	lactate metabolic process
LIT25_13105	COG0277	FAD linked oxidase domain protein
LIT25_13110	COG2186	Transcriptional regulator
LIT25_13115	COG3173	Aminoglycoside phosphotransferase
LIT25_13125	COG0673	inositol 2-dehydrogenase activity
LIT25_13135	COG0673	inositol 2-dehydrogenase activity
LIT25_13140	COG0395	ABC-type sugar transport system, permease component
LIT25_13145	COG1175	transmembrane transport
LIT25_13150	COG1653	transport
LIT25_13160	COG0673	inositol 2-dehydrogenase activity
LIT25_13170	COG3773	Cell wall hydrolase
LIT25_13175	COG0456	acetyltransferase
LIT25_13180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LIT25_13180	COG3153	acetyltransferase
LIT25_13190	COG4191	Histidine kinase
LIT25_13240	COG2318	DinB family
LIT25_13245	COG3340	Belongs to the peptidase S51 family
LIT25_13280	COG1132	(ABC) transporter
LIT25_13290	COG1132	(ABC) transporter
LIT25_13320	COG0367	asparagine synthase
LIT25_13320	COG0367	asparagine synthase
LIT25_13325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LIT25_13335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LIT25_13345	COG1181	Belongs to the D-alanine--D-alanine ligase family
LIT25_13350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LIT25_13395	COG0463	Glycosyl transferase, family 2
LIT25_13400	COG0438	transferase activity, transferring glycosyl groups
LIT25_13405	COG1216	Glycosyl transferase, family 2
LIT25_13410	COG0438	transferase activity, transferring glycosyl groups
LIT25_13415	COG1086	Polysaccharide biosynthesis protein
LIT25_13425	COG0489	protein tyrosine kinase activity
LIT25_13430	COG3944	biosynthesis protein
LIT25_13460	COG1454	alcohol dehydrogenase
LIT25_13475	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_13480	COG1454	alcohol dehydrogenase
LIT25_13485	COG1250	3-hydroxyacyl-CoA dehydrogenase
LIT25_13490	COG0527	aspartate kinase activity
LIT25_13495	COG2223	nitrite transmembrane transporter activity
LIT25_13500	COG1388	LysM domain
LIT25_13500	COG3584	3D domain protein
LIT25_13505	COG1309	transcriptional regulator
LIT25_13510	COG3104	oligopeptide transport
LIT25_13525	COG2205	protein histidine kinase activity
LIT25_13535	COG0561	phosphatase activity
LIT25_13540	COG1349	DNA-binding transcription factor activity
LIT25_13565	COG0076	glutamate decarboxylase activity
LIT25_13575	COG0657	acetylesterase activity
LIT25_13595	COG0351	phosphomethylpyrimidine kinase
LIT25_13600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LIT25_13610	COG1280	lysine exporter protein (LysE YggA)
LIT25_13615	COG0733	neurotransmitter:sodium symporter activity
LIT25_13640	COG0778	Nitroreductase
LIT25_13715	COG0310	cobalt ion transport
LIT25_13735	COG2318	DinB family
LIT25_13750	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_13760	COG1164	Oligoendopeptidase f
LIT25_13765	COG0514	ATP-dependent DNA helicase (RecQ)
LIT25_13785	COG5002	protein histidine kinase activity
LIT25_13800	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_13830	COG4975	Glucose uptake
LIT25_13845	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_13875	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_13910	COG0508	dehydrogenase complex catalyzes the overall conversion of
LIT25_13915	COG0567	Dehydrogenase, E1 component
LIT25_13930	COG4548	von Willebrand factor, type A
LIT25_13935	COG0714	Associated with various cellular activities
LIT25_13975	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LIT25_13990	COG3546	catalase activity
LIT25_14035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LIT25_14040	COG0640	Transcriptional regulator
LIT25_14070	COG0492	ferredoxin-NADP+ reductase activity
LIT25_14100	COG0662	Cupin 2, conserved barrel domain protein
LIT25_14140	COG1533	DNA photolyase activity
LIT25_14160	COG3871	stress protein (general stress protein 26)
LIT25_14165	COG4294	response to UV
LIT25_14190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LIT25_14200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LIT25_14210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_14215	COG2720	vancomycin resistance protein
LIT25_14220	COG1368	sulfuric ester hydrolase activity
LIT25_14225	COG2032	superoxide dismutase activity
LIT25_14240	COG0791	NLP P60 protein
LIT25_14240	COG1388	LysM domain
LIT25_14260	COG2252	PERMEase
LIT25_14265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LIT25_14270	COG0534	Mate efflux family protein
LIT25_14275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LIT25_14280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LIT25_14290	COG2962	Rard protein
LIT25_14305	COG4876	unkown
LIT25_14310	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_14315	COG1733	regulation of RNA biosynthetic process
LIT25_14320	COG0778	Nitroreductase
LIT25_14330	COG0400	carboxylic ester hydrolase activity
LIT25_14335	COG0655	NAD(P)H dehydrogenase (quinone) activity
LIT25_14340	COG0793	Belongs to the peptidase S41A family
LIT25_14340	COG3409	Peptidoglycan-binding domain 1 protein
LIT25_14345	COG2226	methyltransferase
LIT25_14360	COG1876	peptidase activity
LIT25_14365	COG0813	purine-nucleoside phosphorylase activity
LIT25_14380	COG0671	phosphoesterase, PA-phosphatase related
LIT25_14390	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_14395	COG0730	response to heat
LIT25_14430	COG4326	sporulation control protein
LIT25_14435	COG0515	serine threonine protein kinase
LIT25_14435	COG4991	sh3 domain protein
LIT25_14435	COG3064	Membrane
LIT25_14470	COG5522	Integral membrane protein (intg_mem_TP0381)
LIT25_14485	COG1131	(ABC) transporter
LIT25_14515	COG1368	sulfuric ester hydrolase activity
LIT25_14525	COG2814	Major facilitator Superfamily
LIT25_14535	COG3858	chitin binding
LIT25_14540	COG2602	Beta-lactamase
LIT25_14545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LIT25_14550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_14565	COG2814	Major facilitator Superfamily
LIT25_14570	COG2318	DinB family
LIT25_14575	COG0477	Major facilitator Superfamily
LIT25_14580	COG1846	Transcriptional regulator
LIT25_14585	COG4479	Belongs to the UPF0346 family
LIT25_14595	COG1509	lysine 2,3-aminomutase activity
LIT25_14600	COG3829	transcription factor binding
LIT25_14605	COG0456	acetyltransferase
LIT25_14610	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_14615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LIT25_14620	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LIT25_14625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LIT25_14630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LIT25_14650	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LIT25_14660	COG2357	RelA SpoT domain protein
LIT25_14665	COG1393	Belongs to the ArsC family
LIT25_14680	COG0640	Transcriptional regulator
LIT25_14685	COG3290	protein histidine kinase activity
LIT25_14685	COG3829	transcription factor binding
LIT25_14690	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_14695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LIT25_14700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LIT25_14705	COG2610	gluconate transmembrane transporter activity
LIT25_14725	COG0596	Alpha beta hydrolase
LIT25_14740	COG0346	lactoylglutathione lyase activity
LIT25_14745	COG0765	amino acid transport
LIT25_14750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LIT25_14765	COG0697	spore germination
LIT25_14780	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LIT25_14785	COG1131	(ABC) transporter
LIT25_14805	COG0596	Alpha beta hydrolase
LIT25_14845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LIT25_14860	COG4335	DNA alkylation repair
LIT25_14865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LIT25_14870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LIT25_14875	COG0583	DNA-binding transcription factor activity
LIT25_14895	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LIT25_14905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LIT25_14910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LIT25_14920	COG0598	Magnesium transport protein CorA
LIT25_14930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LIT25_14940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LIT25_14945	COG1114	Component of the transport system for branched-chain amino acids
LIT25_14955	COG1785	Belongs to the alkaline phosphatase family
LIT25_14970	COG2226	methyltransferase
LIT25_14980	COG1595	DNA-templated transcription, initiation
LIT25_15010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_15035	COG2814	Major facilitator Superfamily
LIT25_15045	COG3973	AAA domain
LIT25_15055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LIT25_15060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LIT25_15070	COG1131	(ABC) transporter
LIT25_15075	COG2205	protein histidine kinase activity
LIT25_15080	COG0745	RESPONSE REGULATOR receiver
LIT25_15090	COG0596	Alpha beta hydrolase
LIT25_15100	COG3850	Histidine kinase
LIT25_15100	COG5002	protein histidine kinase activity
LIT25_15110	COG1136	(ABC) transporter
LIT25_15115	COG0577	efflux transmembrane transporter activity
LIT25_15125	COG0300	oxidoreductase activity
LIT25_15135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LIT25_15140	COG3191	aminopeptidase activity
LIT25_15145	COG4684	Psort location CytoplasmicMembrane, score
LIT25_15150	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LIT25_15160	COG1122	ATPase activity
LIT25_15170	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_15175	COG0473	3-isopropylmalate dehydrogenase activity
LIT25_15180	COG3829	transcription factor binding
LIT25_15180	COG3290	protein histidine kinase activity
LIT25_15190	COG0583	DNA-binding transcription factor activity
LIT25_15195	COG0372	Belongs to the citrate synthase family
LIT25_15220	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_15225	COG0531	amino acid
LIT25_15230	COG0789	Transcriptional regulator
LIT25_15230	COG4978	Transcriptional regulator
LIT25_15235	COG1404	Belongs to the peptidase S8 family
LIT25_15250	COG2197	response regulator
LIT25_15255	COG4585	Histidine kinase
LIT25_15265	COG2186	Transcriptional regulator
LIT25_15285	COG0384	phenazine biosynthesis protein PhzF
LIT25_15295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LIT25_15325	COG1595	DNA-templated transcription, initiation
LIT25_15340	COG1105	Belongs to the carbohydrate kinase PfkB family
LIT25_15350	COG2222	sugar isomerase
LIT25_15355	COG2188	Transcriptional regulator
LIT25_15360	COG2318	DinB family
LIT25_15375	COG1132	(ABC) transporter
LIT25_15390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LIT25_15395	COG2226	methyltransferase
LIT25_15410	COG1113	amino acid transport
LIT25_15415	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIT25_15430	COG0494	nUDIX hydrolase
LIT25_15435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LIT25_15450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LIT25_15460	COG1609	Transcriptional regulator
LIT25_15475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LIT25_15485	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LIT25_15495	COG1846	Transcriptional regulator
LIT25_15540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LIT25_15560	COG0697	spore germination
LIT25_15565	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LIT25_15570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LIT25_15585	COG1357	PFAM Pentapeptide repeats (8 copies)
LIT25_15605	COG0579	oxidoreductase
LIT25_15610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_15625	COG1131	(ABC) transporter
LIT25_15630	COG1309	transcriptional regulator
LIT25_15640	COG1619	proteins homologs of microcin C7 resistance protein MccF
LIT25_15645	COG2801	Transposase and inactivated derivatives
LIT25_15655	COG3773	Cell wall hydrolase
LIT25_15665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LIT25_15680	COG2188	Transcriptional regulator
LIT25_15695	COG0456	acetyltransferase
LIT25_15745	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LIT25_15775	COG0693	protein deglycase activity
LIT25_15810	COG0640	Transcriptional regulator
LIT25_15840	COG0444	Belongs to the ABC transporter superfamily
LIT25_15845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LIT25_15850	COG0601	transmembrane transport
LIT25_15890	COG2318	DinB family
LIT25_15905	COG2329	Antibiotic biosynthesis monooxygenase
LIT25_15940	COG0662	Cupin 2, conserved barrel domain protein
LIT25_15955	COG3716	PTS system mannose fructose sorbose family IID component
LIT25_15960	COG3715	PTS system
LIT25_15965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_15965	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_15980	COG1940	carbohydrate kinase activity
LIT25_15985	COG0531	amino acid
LIT25_15990	COG2188	Transcriptional regulator
LIT25_16000	COG4821	SIS domain
LIT25_16045	COG2801	Transposase and inactivated derivatives
LIT25_16060	COG2249	NAD(P)H dehydrogenase (quinone) activity
LIT25_16065	COG1733	regulation of RNA biosynthetic process
LIT25_16090	COG0494	nUDIX hydrolase
LIT25_16095	COG2211	Major facilitator Superfamily
LIT25_16105	COG0785	Cytochrome C biogenesis protein
LIT25_16120	COG4974	Belongs to the 'phage' integrase family
LIT25_16140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LIT25_16145	COG0697	spore germination
LIT25_16165	COG0823	Involved in the tonB-independent uptake of proteins
LIT25_16175	COG2329	Antibiotic biosynthesis monooxygenase
LIT25_16240	COG2801	Transposase and inactivated derivatives
LIT25_16275	COG2112	serine threonine protein kinase
LIT25_16340	COG0515	serine threonine protein kinase
LIT25_16360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LIT25_16370	COG2267	carboxylic ester hydrolase activity
LIT25_16395	COG2808	Putative FMN-binding domain
LIT25_16405	COG1278	Cold shock
LIT25_16420	COG0456	acetyltransferase
LIT25_16425	COG0346	lactoylglutathione lyase activity
LIT25_16430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LIT25_16430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LIT25_16435	COG1846	Transcriptional regulator
LIT25_16465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LIT25_16475	COG4698	Protein conserved in bacteria
LIT25_16490	COG1999	signal sequence binding
LIT25_16510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LIT25_16515	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LIT25_16520	COG1272	protein, Hemolysin III
LIT25_16525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LIT25_16545	COG0861	Integral membrane protein TerC family
LIT25_16550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LIT25_16565	COG2136	Putative SAM-dependent methyltransferase
LIT25_16565	COG2521	methyltransferase
LIT25_16575	COG0129	dihydroxy-acid dehydratase activity
LIT25_16580	COG0024	Methionine aminopeptidase
LIT25_16585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LIT25_16590	COG1413	lyase activity
LIT25_16595	COG1418	mRNA catabolic process
LIT25_16610	COG0386	Belongs to the glutathione peroxidase family
LIT25_16630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LIT25_16635	COG1988	membrane-bound metal-dependent
LIT25_16650	COG2226	methyltransferase
LIT25_16680	COG1278	Cold shock
LIT25_16705	COG0328	RNA-DNA hybrid ribonuclease activity
LIT25_16720	COG0702	epimerase
LIT25_16725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LIT25_16745	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LIT25_16765	COG0490	domain, Protein
LIT25_16775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LIT25_16790	COG1755	Isoprenylcysteine carboxyl methyltransferase
LIT25_16795	COG3424	synthase
LIT25_16810	COG1376	ErfK ybiS ycfS ynhG family protein
LIT25_16820	COG2233	PERMEase
LIT25_16835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LIT25_16840	COG1199	ATP-dependent helicase activity
LIT25_16850	COG0116	Belongs to the methyltransferase superfamily
LIT25_16880	COG3359	exonuclease
LIT25_16900	COG1205	dead DEAH box helicase
LIT25_16900	COG1111	helicase
LIT25_16915	COG2190	(PTS) system
LIT25_16980	COG3331	DNA recombination
LIT25_16985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LIT25_16985	COG4499	WXG100 protein secretion system (Wss), protein YukC
LIT25_16995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LIT25_17000	COG3935	DnaD domain protein
LIT25_17005	COG0017	Asparaginyl-tRNA synthetase
LIT25_17010	COG0436	Aminotransferase
LIT25_17025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LIT25_17025	COG1199	ATP-dependent helicase activity
LIT25_17030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LIT25_17035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LIT25_17040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LIT25_17050	COG0617	tRNA 3'-terminal CCA addition
LIT25_17055	COG0438	transferase activity, transferring glycosyl groups
LIT25_17060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LIT25_17065	COG1803	Methylglyoxal synthase
LIT25_17070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LIT25_17075	COG1694	Mazg nucleotide pyrophosphohydrolase
LIT25_17080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_17090	COG4347	Protein of unknown function (DUF1405)
LIT25_17095	COG2010	Cytochrome c
LIT25_17095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LIT25_17100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LIT25_17105	COG0723	plastoquinol--plastocyanin reductase activity
LIT25_17120	COG1874	Beta-galactosidase
LIT25_17120	COG0366	Alpha amylase catalytic
LIT25_17125	COG5582	Belongs to the UPF0302 family
LIT25_17130	COG0457	Tetratricopeptide repeat
LIT25_17145	COG0287	Prephenate dehydrogenase
LIT25_17155	COG0159	tryptophan synthase activity
LIT25_17160	COG0133	tryptophan synthase activity
LIT25_17165	COG0135	phosphoribosylanthranilate isomerase activity
LIT25_17170	COG0134	indole-3-glycerol-phosphate synthase activity
LIT25_17175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LIT25_17180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LIT25_17185	COG4401	Chorismate mutase type I
LIT25_17190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LIT25_17195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LIT25_17205	COG0105	UTP biosynthetic process
LIT25_17210	COG0142	geranyltranstransferase activity
LIT25_17215	COG2226	methyltransferase
LIT25_17220	COG0142	geranyltranstransferase activity
LIT25_17235	COG0776	regulation of translation
LIT25_17240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LIT25_17260	COG1160	GTP binding
LIT25_17285	COG1304	FMN binding
LIT25_17290	COG0539	negative regulation of cytoplasmic translation
LIT25_17300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LIT25_17320	COG2959	enzyme of heme biosynthesis
LIT25_17325	COG3773	Cell wall hydrolase
LIT25_17325	COG3409	Peptidoglycan-binding domain 1 protein
LIT25_17330	COG2339	peptidase activity
LIT25_17350	COG0492	ferredoxin-NADP+ reductase activity
LIT25_17355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LIT25_17360	COG4862	establishment of competence for transformation
LIT25_17365	COG0789	Transcriptional regulator
LIT25_17390	COG1266	CAAX protease self-immunity
LIT25_17395	COG0514	ATP-dependent DNA helicase (RecQ)
LIT25_17400	COG4955	Helix-turn-helix domain
LIT25_17405	COG1141	Ferredoxin
LIT25_17410	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LIT25_17415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LIT25_17420	COG5002	protein histidine kinase activity
LIT25_17425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LIT25_17430	COG1705	Flagellar rod assembly protein muramidase FlgJ
LIT25_17430	COG1388	LysM domain
LIT25_17440	COG1595	DNA-templated transcription, initiation
LIT25_17445	COG2096	Adenosyltransferase
LIT25_17460	COG5002	protein histidine kinase activity
LIT25_17465	COG0745	RESPONSE REGULATOR receiver
LIT25_17470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LIT25_17475	COG1333	cytochrome c biogenesis protein
LIT25_17480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_17485	COG1187	pseudouridine synthase activity
LIT25_17490	COG0700	Nucleoside recognition
LIT25_17495	COG2715	membrane protein required for spore maturation
LIT25_17500	COG1686	Belongs to the peptidase S11 family
LIT25_17515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LIT25_17530	COG1547	Domain of unknown function (DUF309)
LIT25_17540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LIT25_17545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LIT25_17545	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LIT25_17550	COG0307	riboflavin synthase, alpha
LIT25_17555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LIT25_17555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LIT25_17565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LIT25_17570	COG4086	secreted protein
LIT25_17575	COG0019	diaminopimelate decarboxylase activity
LIT25_17580	COG0697	spore germination
LIT25_17595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LIT25_17625	COG1366	Belongs to the anti-sigma-factor antagonist family
LIT25_17630	COG1686	Belongs to the peptidase S11 family
LIT25_17645	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LIT25_17650	COG4974	Belongs to the 'phage' integrase family
LIT25_17660	COG0735	belongs to the Fur family
LIT25_17665	COG1300	Membrane
LIT25_17680	COG1379	DNA repair
LIT25_17685	COG0494	nUDIX hydrolase
LIT25_17695	COG0667	Aldo Keto reductase
LIT25_17710	COG1388	LysM domain
LIT25_17710	COG0791	NLP P60 protein
LIT25_17715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LIT25_17725	COG0523	cobalamin synthesis protein
LIT25_17740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LIT25_17745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LIT25_17750	COG0183	Belongs to the thiolase family
LIT25_17755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LIT25_17765	COG1073	alpha beta
LIT25_17790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LIT25_17800	COG0300	oxidoreductase activity
LIT25_17805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_17810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LIT25_17830	COG4187	Peptidase family M20/M25/M40
LIT25_17835	COG1902	pentaerythritol trinitrate reductase activity
LIT25_17865	COG4977	sequence-specific DNA binding
LIT25_17865	COG1917	Cupin 2, conserved barrel domain protein
LIT25_17875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LIT25_17880	COG2814	Major facilitator Superfamily
LIT25_17890	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LIT25_17895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LIT25_17900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LIT25_17905	COG2195	Cleaves the N-terminal amino acid of tripeptides
LIT25_17910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LIT25_17915	COG0346	lactoylglutathione lyase activity
LIT25_17925	COG1376	ErfK ybiS ycfS ynhG family protein
LIT25_17930	COG4129	membrane
LIT25_17935	COG1126	abc transporter atp-binding protein
LIT25_17940	COG0765	amino acid transport
LIT25_17945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LIT25_17955	COG1703	isobutyryl-CoA mutase activity
LIT25_17960	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIT25_17960	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIT25_17965	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIT25_17970	COG1597	lipid kinase activity
LIT25_17975	COG0508	dehydrogenase complex catalyzes the overall conversion of
LIT25_17980	COG0022	dehydrogenase e1 component
LIT25_17985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LIT25_17990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LIT25_17995	COG3426	butyrate kinase activity
LIT25_18005	COG0280	phosphate acetyltransferase
LIT25_18010	COG3829	transcription factor binding
LIT25_18010	COG3290	protein histidine kinase activity
LIT25_18020	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_18025	COG3093	addiction module antidote protein HigA
LIT25_18030	COG0745	RESPONSE REGULATOR receiver
LIT25_18035	COG0750	zinc metalloprotease
LIT25_18040	COG0497	DNA recombination
LIT25_18045	COG1438	arginine binding
LIT25_18050	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LIT25_18055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LIT25_18060	COG0142	geranyltranstransferase activity
LIT25_18065	COG1722	exodeoxyribonuclease VII activity
LIT25_18070	COG1570	exodeoxyribonuclease VII activity
LIT25_18075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LIT25_18080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LIT25_18085	COG1302	Protein conserved in bacteria
LIT25_18090	COG0439	Biotin carboxylase
LIT25_18095	COG0511	ligase activity, forming carbon-carbon bonds
LIT25_18135	COG3854	ATPases associated with a variety of cellular activities
LIT25_18150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LIT25_18155	COG0006	proline dipeptidase activity
LIT25_18160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LIT25_18170	COG3872	metal-dependent enzyme
LIT25_18180	COG1752	Esterase of the alpha-beta hydrolase superfamily
LIT25_18195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LIT25_18200	COG0095	Lipoate-protein ligase
LIT25_18205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LIT25_18210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LIT25_18215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LIT25_18220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LIT25_18225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LIT25_18285	COG4940	Competence protein ComGF
LIT25_18295	COG4970	Tfp pilus assembly protein FimT
LIT25_18300	COG4537	Required for transformation and DNA binding
LIT25_18305	COG1459	type II secretion system
LIT25_18310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LIT25_18355	COG1204	response to ionizing radiation
LIT25_18390	COG2385	sporulation resulting in formation of a cellular spore
LIT25_18400	COG0860	N-Acetylmuramoyl-L-alanine amidase
LIT25_18525	COG1388	LysM domain
LIT25_18575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LIT25_18665	COG1393	Belongs to the ArsC family
LIT25_18680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_18695	COG0011	TIGRFAM Protein of
LIT25_18710	COG1368	sulfuric ester hydrolase activity
LIT25_18715	COG1940	carbohydrate kinase activity
LIT25_18720	COG4483	Protein conserved in bacteria
LIT25_18725	COG0457	Tetratricopeptide repeat
LIT25_18725	COG0705	Rhomboid family
LIT25_18740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LIT25_18750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LIT25_18770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LIT25_18775	COG0704	Plays a role in the regulation of phosphate uptake
LIT25_18780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LIT25_18785	COG0581	inorganic phosphate transmembrane transporter activity
LIT25_18790	COG0573	inorganic phosphate transmembrane transporter activity
LIT25_18800	COG0768	penicillin binding
LIT25_18805	COG0477	Major facilitator Superfamily
LIT25_18815	COG2839	Protein conserved in bacteria
LIT25_18820	COG1283	sodium-dependent phosphate transmembrane transporter activity
LIT25_18825	COG5521	maltodextrose utilization protein MalA
LIT25_18835	COG1388	LysM domain
LIT25_18845	COG4709	membrane
LIT25_18850	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
LIT25_18855	COG0735	belongs to the Fur family
LIT25_18860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LIT25_18865	COG1121	(ABC) transporter
LIT25_18870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_18880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LIT25_18885	COG0513	Belongs to the DEAD box helicase family
LIT25_18895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LIT25_18900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LIT25_18905	COG2384	SAM-dependent methyltransferase
LIT25_18910	COG2010	Cytochrome c
LIT25_18915	COG1960	acyl-CoA dehydrogenase activity
LIT25_18920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LIT25_18925	COG0358	DNA primase activity
LIT25_18930	COG1671	Belongs to the UPF0178 family
LIT25_18940	COG0517	IMP dehydrogenase activity
LIT25_18945	COG0751	glycine-tRNA ligase activity
LIT25_18950	COG0752	glycyl-tRNA synthetase alpha subunit
LIT25_18955	COG1381	Involved in DNA repair and RecF pathway recombination
LIT25_18965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LIT25_18970	COG0295	cytidine deaminase activity
LIT25_18975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LIT25_18985	COG1480	7TM receptor with intracellular HD hydrolase
LIT25_18990	COG1702	phosphate starvation-inducible protein PhoH
LIT25_19010	COG4864	UPF0365 protein
LIT25_19015	COG1030	water channel activity
LIT25_19020	COG1610	YqeY-like protein
LIT25_19025	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LIT25_19030	COG1283	sodium-dependent phosphate transmembrane transporter activity
LIT25_19035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LIT25_19040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LIT25_19045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LIT25_19050	COG2264	protein methyltransferase activity
LIT25_19055	COG0484	heat shock protein binding
LIT25_19060	COG0443	Heat shock 70 kDa protein
LIT25_19065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LIT25_19075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LIT25_19080	COG0481	GTPase activity
LIT25_19090	COG0860	N-Acetylmuramoyl-L-alanine amidase
LIT25_19100	COG0268	Binds directly to 16S ribosomal RNA
LIT25_19105	COG1466	dna polymerase III delta subunit
LIT25_19115	COG2333	competence protein COMEC
LIT25_19115	COG0658	competence protein
LIT25_19120	COG2131	deaminase
LIT25_19125	COG1555	photosystem II stabilization
LIT25_19125	COG1596	polysaccharide export
LIT25_19130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LIT25_19135	COG2226	methyltransferase
LIT25_19140	COG0799	negative regulation of ribosome biogenesis
LIT25_19145	COG1713	HD superfamily hydrolase involved in NAD metabolism
LIT25_19150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LIT25_19155	COG1534	Rna-binding protein
LIT25_19165	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LIT25_19170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LIT25_19180	COG0688	phosphatidylethanolamine metabolic process
LIT25_19185	COG1183	phosphatidylcholine synthase activity
LIT25_19205	COG2755	lipolytic protein G-D-S-L family
LIT25_19215	COG0626	cystathionine gamma-synthase activity
LIT25_19220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LIT25_19230	COG2226	methyltransferase
LIT25_19245	COG0768	penicillin binding
LIT25_19250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LIT25_19255	COG0572	uridine kinase
LIT25_19260	COG0826	peptidase U32
LIT25_19265	COG0826	peptidase U32
LIT25_19270	COG4122	O-methyltransferase activity
LIT25_19275	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LIT25_19280	COG3906	Belongs to the UPF0473 family
LIT25_19285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LIT25_19290	COG4472	Bacterial protein of unknown function (DUF965)
LIT25_19295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LIT25_19300	COG0628	permease
LIT25_19320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LIT25_19335	COG1104	cysteine desulfurase activity
LIT25_19340	COG1959	2 iron, 2 sulfur cluster binding
LIT25_19345	COG2364	Membrane
LIT25_19350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LIT25_19355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LIT25_19365	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LIT25_19380	COG0860	N-Acetylmuramoyl-L-alanine amidase
LIT25_19380	COG3103	Sh3 type 3 domain protein
LIT25_19380	COG4991	sh3 domain protein
LIT25_19385	COG1490	D-aminoacyl-tRNA deacylase activity
LIT25_19390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LIT25_19400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LIT25_19400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LIT25_19405	COG5416	Lipopolysaccharide assembly protein A domain
LIT25_19410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LIT25_19410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LIT25_19420	COG2244	polysaccharide biosynthetic process
LIT25_19425	COG2323	membrane
LIT25_19435	COG1862	Preprotein translocase
LIT25_19445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LIT25_19455	COG2255	four-way junction helicase activity
LIT25_19460	COG0632	four-way junction helicase activity
LIT25_19480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LIT25_19485	COG0157	Belongs to the NadC ModD family
LIT25_19490	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LIT25_19495	COG1104	cysteine desulfurase activity
LIT25_19500	COG1827	regulation of RNA biosynthetic process
LIT25_19505	COG0077	Prephenate dehydratase
LIT25_19510	COG4492	Belongs to the UPF0735 family
LIT25_19520	COG3290	protein histidine kinase activity
LIT25_19530	COG2868	ribosomal protein
LIT25_19535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LIT25_19540	COG1530	ribonuclease E activity
LIT25_19545	COG1994	Peptidase M50
LIT25_19550	COG0739	heme binding
LIT25_19555	COG2894	cell division
LIT25_19560	COG0850	regulation of cytokinetic process
LIT25_19565	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LIT25_19575	COG1077	Cell shape determining protein MreB Mrl
LIT25_19580	COG2003	Belongs to the UPF0758 family
LIT25_19615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LIT25_19635	COG0243	molybdopterin cofactor binding
LIT25_19665	COG2223	nitrite transmembrane transporter activity
LIT25_19675	COG2197	response regulator
LIT25_19690	COG3706	GGDEF domain
LIT25_19695	COG0285	dihydrofolate synthase activity
LIT25_19700	COG0525	valine-tRNA ligase activity
LIT25_19710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LIT25_19715	COG1388	LysM domain
LIT25_19725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LIT25_19730	COG0113	porphobilinogen synthase activity
LIT25_19740	COG0181	hydroxymethylbilane synthase activity
LIT25_19745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LIT25_19765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LIT25_19770	COG1067	ATP-dependent peptidase activity
LIT25_19770	COG0470	DNA polymerase III
LIT25_19775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LIT25_19780	COG0544	peptidyl-prolyl cis-trans isomerase activity
LIT25_19785	COG0457	Tetratricopeptide repeat
LIT25_19785	COG1477	protein flavinylation
LIT25_19790	COG0066	3-isopropylmalate dehydratase activity
LIT25_19795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LIT25_19800	COG0473	3-isopropylmalate dehydrogenase activity
LIT25_19805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LIT25_19810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LIT25_19815	COG0440	acetolactate synthase activity
LIT25_19820	COG0028	Belongs to the TPP enzyme family
LIT25_19825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LIT25_19835	COG0622	Phosphoesterase
LIT25_19840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LIT25_19845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LIT25_19850	COG5401	PFAM Sporulation and spore germination
LIT25_19860	COG1846	Transcriptional regulator
LIT25_19865	COG2197	response regulator
LIT25_19870	COG0824	Thioesterase
LIT25_19875	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LIT25_19880	COG1053	succinate dehydrogenase
LIT25_19885	COG2009	succinate dehydrogenase
LIT25_19890	COG1719	4-vinyl reductase, 4VR
LIT25_19895	COG0527	aspartate kinase activity
LIT25_19900	COG0322	excinuclease ABC activity
LIT25_19905	COG3118	belongs to the thioredoxin family
LIT25_19910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LIT25_19915	COG2086	electron transfer activity
LIT25_19920	COG1024	Enoyl-CoA hydratase
LIT25_19925	COG1309	transcriptional regulator
LIT25_19930	COG0318	PFAM AMP-dependent synthetase and ligase
LIT25_19935	COG3766	membrane
LIT25_19940	COG1193	negative regulation of DNA recombination
LIT25_19945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LIT25_19945	COG1796	DNA polymerase
LIT25_19950	COG1286	toxin biosynthetic process
LIT25_19955	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LIT25_19960	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LIT25_19965	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LIT25_19975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LIT25_19980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LIT25_19980	COG0072	phenylalanine-tRNA ligase activity
LIT25_19985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LIT25_19990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LIT25_20000	COG1363	Peptidase, m42
LIT25_20020	COG3326	Membrane
LIT25_20025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LIT25_20035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LIT25_20040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LIT25_20050	COG1484	DNA-dependent DNA replication
LIT25_20055	COG3611	Membrane attachment protein
LIT25_20060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LIT25_20070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LIT25_20075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LIT25_20080	COG0237	dephospho-CoA kinase activity
LIT25_20085	COG1971	Probably functions as a manganese efflux pump
LIT25_20090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LIT25_20095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LIT25_20095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LIT25_20100	COG0330	HflC and HflK could
LIT25_20105	COG0330	HflC and HflK could
LIT25_20110	COG5002	protein histidine kinase activity
LIT25_20115	COG0745	RESPONSE REGULATOR receiver
LIT25_20125	COG0039	L-malate dehydrogenase activity
LIT25_20130	COG0538	isocitrate dehydrogenase activity
LIT25_20135	COG0372	Belongs to the citrate synthase family
LIT25_20140	COG2707	UPF0756 membrane protein
LIT25_20145	COG0628	permease
LIT25_20150	COG3030	protein affecting phage T7 exclusion by the F plasmid
LIT25_20165	COG0825	malonyl-CoA metabolic process
LIT25_20170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LIT25_20175	COG1725	Transcriptional regulator
LIT25_20180	COG0281	malic enzyme
LIT25_20185	COG0587	DNA-directed DNA polymerase activity
LIT25_20205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LIT25_20215	COG4109	DRTGG domain
LIT25_20225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LIT25_20240	COG3547	Transposase (IS116 IS110 IS902 family)
LIT25_20260	COG4585	Histidine kinase
LIT25_20265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LIT25_20285	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_20300	COG0165	Argininosuccinate lyase
LIT25_20305	COG0137	argininosuccinate synthase activity
LIT25_20325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LIT25_20330	COG0827	DNA restriction-modification system
LIT25_20335	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LIT25_20340	COG3874	Sporulation protein YtfJ
LIT25_20350	COG1714	RDD family
LIT25_20355	COG0616	signal peptide processing
LIT25_20360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LIT25_20365	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LIT25_20370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LIT25_20385	COG0301	tRNA thio-modification
LIT25_20390	COG1104	cysteine desulfurase activity
LIT25_20395	COG1114	Component of the transport system for branched-chain amino acids
LIT25_20400	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LIT25_20405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LIT25_20410	COG1309	transcriptional regulator
LIT25_20415	COG1956	GAF domain-containing protein
LIT25_20420	COG0626	cystathionine gamma-synthase activity
LIT25_20430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LIT25_20455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LIT25_20460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LIT25_20465	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LIT25_20470	COG3457	Alanine racemase
LIT25_20475	COG0626	cystathionine gamma-synthase activity
LIT25_20480	COG1735	metal-dependent hydrolase with the TIM-barrel fold
LIT25_20500	COG2188	Transcriptional regulator
LIT25_20505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LIT25_20515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LIT25_20520	COG0454	-acetyltransferase
LIT25_20525	COG0517	IMP dehydrogenase activity
LIT25_20530	COG0123	including yeast histone deacetylase and acetoin utilization protein
LIT25_20535	COG1609	Transcriptional regulator
LIT25_20540	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LIT25_20540	COG1605	Chorismate mutase
LIT25_20555	COG3118	belongs to the thioredoxin family
LIT25_20565	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
LIT25_20570	COG2309	aminopeptidase activity
LIT25_20580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LIT25_20585	COG1674	ftsk spoiiie
LIT25_20590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LIT25_20595	COG4848	Belongs to the UPF0354 family
LIT25_20600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_20615	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LIT25_20620	COG1363	Peptidase, m42
LIT25_20625	COG5584	Small secreted protein
LIT25_20630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_20635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LIT25_20645	COG0510	thiamine kinase activity
LIT25_20650	COG1523	belongs to the glycosyl hydrolase 13 family
LIT25_20665	COG1346	cytolysis
LIT25_20670	COG1380	Effector of murein hydrolase LrgA
LIT25_20675	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LIT25_20680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LIT25_20690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LIT25_20695	COG2252	PERMEase
LIT25_20700	COG1349	DNA-binding transcription factor activity
LIT25_20705	COG1187	pseudouridine synthase activity
LIT25_20710	COG2244	polysaccharide biosynthetic process
LIT25_20715	COG2081	HI0933 family
LIT25_20730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LIT25_20735	COG0495	leucyl-tRNA aminoacylation
LIT25_20745	COG2814	Major facilitator Superfamily
LIT25_20755	COG0577	efflux transmembrane transporter activity
LIT25_20760	COG1136	(ABC) transporter
LIT25_20770	COG1131	(ABC) transporter
LIT25_20775	COG1725	Transcriptional regulator
LIT25_20790	COG1242	4 iron, 4 sulfur cluster binding
LIT25_20795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LIT25_20810	COG2267	carboxylic ester hydrolase activity
LIT25_20815	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LIT25_20820	COG0671	phosphoesterase, PA-phosphatase related
LIT25_20825	COG0438	transferase activity, transferring glycosyl groups
LIT25_20830	COG0367	asparagine synthase
LIT25_20835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LIT25_20840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LIT25_20860	COG1506	peptidase
LIT25_20865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LIT25_20870	COG1116	anion transmembrane transporter activity
LIT25_20875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LIT25_20880	COG1404	Belongs to the peptidase S8 family
LIT25_20890	COG0494	nUDIX hydrolase
LIT25_20910	COG0783	Belongs to the Dps family
LIT25_20920	COG1404	Belongs to the peptidase S8 family
LIT25_20930	COG0701	Predicted permease
LIT25_20935	COG1469	GTP cyclohydrolase I activity
LIT25_20940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LIT25_20955	COG0788	formyltetrahydrofolate deformylase activity
LIT25_20965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LIT25_20970	COG0288	reversible hydration of carbon dioxide
LIT25_20975	COG0523	cobalamin synthesis protein
LIT25_20995	COG1271	oxidase subunit
LIT25_21000	COG1294	oxidase, subunit
LIT25_21010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LIT25_21015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LIT25_21015	COG1321	iron dependent repressor
LIT25_21020	COG1121	(ABC) transporter
LIT25_21025	COG0803	Belongs to the bacterial solute-binding protein 9 family
LIT25_21030	COG4948	Mandelate Racemase Muconate Lactonizing
LIT25_21040	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LIT25_21045	COG0596	Alpha beta hydrolase
LIT25_21050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LIT25_21055	COG1169	isochorismate synthase
LIT25_21060	COG1575	Belongs to the MenA family. Type 1 subfamily
LIT25_21065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LIT25_21080	COG0058	SHG alpha-glucan phosphorylase activity
LIT25_21085	COG0297	glycogen (starch) synthase activity
LIT25_21090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LIT25_21095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LIT25_21225	COG1116	anion transmembrane transporter activity
LIT25_21230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LIT25_21235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LIT25_21245	COG3859	Proton-coupled thiamine transporter YuaJ
LIT25_21260	COG1247	-acetyltransferase
LIT25_21280	COG0318	PFAM AMP-dependent synthetase and ligase
LIT25_21285	COG2318	DinB family
LIT25_21295	COG4974	Belongs to the 'phage' integrase family
LIT25_21485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LIT25_21490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LIT25_21495	COG4172	Belongs to the ABC transporter superfamily
LIT25_21500	COG4721	ABC-type cobalt transport system, permease component
LIT25_21505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LIT25_21520	COG2814	Major facilitator Superfamily
LIT25_21555	COG0673	inositol 2-dehydrogenase activity
LIT25_21565	COG0395	ABC-type sugar transport system, permease component
LIT25_21570	COG1175	transmembrane transport
LIT25_21575	COG1653	transport
LIT25_21580	COG0673	inositol 2-dehydrogenase activity
LIT25_21585	COG0673	inositol 2-dehydrogenase activity
LIT25_21590	COG0673	inositol 2-dehydrogenase activity
LIT25_21600	COG1940	carbohydrate kinase activity
LIT25_21605	COG1216	Glycosyl transferase, family 2
LIT25_21635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_21660	COG4948	Mandelate Racemase Muconate Lactonizing
LIT25_21670	COG1473	amidohydrolase
LIT25_21675	COG1737	Transcriptional regulator
LIT25_21680	COG3584	3D domain protein
LIT25_21680	COG1388	LysM domain
LIT25_21700	COG0730	response to heat
LIT25_21705	COG4129	membrane
LIT25_21710	COG5002	protein histidine kinase activity
LIT25_21760	COG1522	sequence-specific DNA binding
LIT25_21800	COG0822	iron-sulfur transferase activity
LIT25_21805	COG0523	cobalamin synthesis protein
LIT25_21815	COG0523	cobalamin synthesis protein
LIT25_21820	COG0803	Belongs to the bacterial solute-binding protein 9 family
LIT25_21825	COG1121	(ABC) transporter
LIT25_21830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LIT25_21835	COG0717	Belongs to the dCTP deaminase family
LIT25_21845	COG0640	Transcriptional regulator
LIT25_21850	COG2814	Major facilitator Superfamily
LIT25_21855	COG1376	ErfK ybiS ycfS ynhG family protein
LIT25_21860	COG1231	oxidoreductase activity
LIT25_21880	COG1609	Transcriptional regulator
LIT25_21885	COG3540	Alkaline phosphatase
LIT25_21890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_21905	COG2124	cytochrome p450
LIT25_21925	COG4284	Utp--glucose-1-phosphate uridylyltransferase
LIT25_21935	COG0492	ferredoxin-NADP+ reductase activity
LIT25_21940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LIT25_21960	COG0402	S-adenosylhomocysteine deaminase activity
LIT25_21970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LIT25_21975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LIT25_21980	COG1447	Phosphotransferase system cellobiose-specific component IIA
LIT25_21985	COG1486	melibiose metabolic process
LIT25_21995	COG2259	Doxx family
LIT25_22000	COG0501	Belongs to the peptidase M48B family
LIT25_22010	COG2176	DNA-directed DNA polymerase activity
LIT25_22020	COG3708	Transcriptional regulator
LIT25_22020	COG2207	Transcriptional regulator
LIT25_22025	COG1247	-acetyltransferase
LIT25_22040	COG0833	amino acid
LIT25_22050	COG0604	alcohol dehydrogenase
LIT25_22065	COG1785	Belongs to the alkaline phosphatase family
LIT25_22085	COG1113	amino acid transport
LIT25_22090	COG3540	Alkaline phosphatase
LIT25_22110	COG0805	protein transport
LIT25_22115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_22125	COG1733	regulation of RNA biosynthetic process
LIT25_22130	COG0673	inositol 2-dehydrogenase activity
LIT25_22135	COG1285	pathogenesis
LIT25_22140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LIT25_22145	COG1309	transcriptional regulator
LIT25_22150	COG2112	serine threonine protein kinase
LIT25_22165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LIT25_22165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LIT25_22165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_22170	COG1105	Belongs to the carbohydrate kinase PfkB family
LIT25_22175	COG1349	DNA-binding transcription factor activity
LIT25_22180	COG1132	(ABC) transporter
LIT25_22195	COG1823	symporter activity
LIT25_22215	COG3844	kynureninase activity
LIT25_22220	COG2070	2-Nitropropane dioxygenase
LIT25_22230	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
LIT25_22240	COG0432	Pfam Uncharacterised protein family UPF0047
LIT25_22245	COG0366	Alpha amylase catalytic
LIT25_22250	COG1253	flavin adenine dinucleotide binding
LIT25_22265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LIT25_22275	COG1683	Conserved Protein
LIT25_22300	COG1979	alcohol dehydrogenase
LIT25_22305	COG2155	Conserved Protein
LIT25_22310	COG1098	S1 RNA binding domain
LIT25_22325	COG0436	Aminotransferase
LIT25_22330	COG1522	sequence-specific DNA binding
LIT25_22335	COG2267	carboxylic ester hydrolase activity
LIT25_22345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LIT25_22360	COG2032	superoxide dismutase activity
LIT25_22375	COG5018	Exonuclease
LIT25_22380	COG2814	Major facilitator Superfamily
LIT25_22385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LIT25_22390	COG3011	Protein conserved in bacteria
LIT25_22405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LIT25_22405	COG2111	Na H antiporter
LIT25_22410	COG2111	Na H antiporter
LIT25_22415	COG1006	Multisubunit Na H antiporter MnhC subunit
LIT25_22420	COG0651	ATP synthesis coupled electron transport
LIT25_22425	COG1863	multisubunit Na H antiporter MnhE subunit
LIT25_22430	COG2212	antiporter activity
LIT25_22435	COG1320	monovalent cation:proton antiporter activity
LIT25_22445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_22450	COG2050	protein possibly involved in aromatic compounds catabolism
LIT25_22455	COG2133	pyrroloquinoline quinone binding
LIT25_22465	COG2197	response regulator
LIT25_22470	COG4585	Histidine kinase
LIT25_22480	COG0142	geranyltranstransferase activity
LIT25_22500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LIT25_22505	COG2910	NAD(P)H-binding
LIT25_22510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LIT25_22515	COG1959	2 iron, 2 sulfur cluster binding
LIT25_22520	COG4989	oxidoreductase activity
LIT25_22540	COG5506	Protein of unknown function (DUF1694)
LIT25_22550	COG2368	4-hydroxyphenylacetate
LIT25_22555	COG0243	molybdopterin cofactor binding
LIT25_22565	COG1609	Transcriptional regulator
LIT25_22575	COG0628	permease
LIT25_22585	COG1253	flavin adenine dinucleotide binding
LIT25_22590	COG0789	Transcriptional regulator
LIT25_22595	COG0398	Pfam SNARE associated Golgi protein
LIT25_22605	COG1418	mRNA catabolic process
LIT25_22625	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_22630	COG0737	Belongs to the 5'-nucleotidase family
LIT25_22635	COG2508	Transcriptional regulator
LIT25_22635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LIT25_22640	COG0686	Belongs to the AlaDH PNT family
LIT25_22645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LIT25_22650	COG0697	spore germination
LIT25_22655	COG4191	Histidine kinase
LIT25_22660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LIT25_22665	COG1268	BioY protein
LIT25_22685	COG2056	Na+-H+ antiporter family
LIT25_22690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LIT25_22700	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
LIT25_22710	COG3584	3D domain protein
LIT25_22730	COG1252	NADH dehydrogenase
LIT25_22735	COG0492	ferredoxin-NADP+ reductase activity
LIT25_22750	COG0316	Belongs to the HesB IscA family
LIT25_22755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LIT25_22770	COG1252	NADH dehydrogenase
LIT25_22775	COG3547	Transposase (IS116 IS110 IS902 family)
LIT25_22810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LIT25_22815	COG4837	Protein of unknown function (DUF1462)
LIT25_22825	COG0823	Involved in the tonB-independent uptake of proteins
LIT25_22825	COG1506	peptidase
LIT25_22825	COG4946	Tricorn protease homolog
LIT25_22830	COG0083	homoserine kinase activity
LIT25_22835	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LIT25_22840	COG0460	homoserine dehydrogenase
LIT25_22850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LIT25_22855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LIT25_22860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LIT25_22865	COG0647	UMP catabolic process
LIT25_22870	COG2445	Protein of unknown function DUF86
LIT25_22885	COG4470	Protein conserved in bacteria
LIT25_22900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LIT25_22905	COG0739	heme binding
LIT25_22915	COG3377	Domain of unknown function (DUF1805)
LIT25_22920	COG0737	Belongs to the 5'-nucleotidase family
LIT25_22925	COG0730	response to heat
LIT25_22930	COG1801	Protein of unknown function DUF72
LIT25_22935	COG4412	M6 family metalloprotease domain protein
LIT25_22935	COG1404	Belongs to the peptidase S8 family
LIT25_22940	COG4412	M6 family metalloprotease domain protein
LIT25_22940	COG1404	Belongs to the peptidase S8 family
LIT25_22975	COG0719	Fe-S assembly protein
LIT25_22980	COG0822	iron-sulfur transferase activity
LIT25_22985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LIT25_22990	COG0719	Fe-S assembly protein
LIT25_22995	COG0396	ATPase activity
LIT25_23000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LIT25_23005	COG1464	Belongs to the NlpA lipoprotein family
LIT25_23010	COG2011	ABC-type metal ion transport system permease component
LIT25_23015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LIT25_23020	COG2873	o-acetylhomoserine
LIT25_23030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_23035	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LIT25_23045	COG0509	glycine decarboxylation via glycine cleavage system
LIT25_23050	COG1393	Belongs to the ArsC family
LIT25_23055	COG1960	acyl-CoA dehydrogenase activity
LIT25_23060	COG0183	Belongs to the thiolase family
LIT25_23065	COG1024	Enoyl-CoA hydratase
LIT25_23065	COG1250	3-hydroxyacyl-CoA dehydrogenase
LIT25_23085	COG5577	PFAM Coat F domain
LIT25_23090	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LIT25_23115	COG1120	ATPase activity
LIT25_23120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LIT25_23125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LIT25_23130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LIT25_23135	COG1960	acyl-CoA dehydrogenase activity
LIT25_23145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LIT25_23150	COG0569	domain protein
LIT25_23155	COG0745	RESPONSE REGULATOR receiver
LIT25_23160	COG5002	protein histidine kinase activity
LIT25_23180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_23185	COG0531	amino acid
LIT25_23195	COG2205	protein histidine kinase activity
LIT25_23205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LIT25_23260	COG1686	Belongs to the peptidase S11 family
LIT25_23270	COG2076	Multidrug Resistance protein
LIT25_23275	COG2076	Multidrug Resistance protein
LIT25_23290	COG1595	DNA-templated transcription, initiation
LIT25_23295	COG1609	Transcriptional regulator
LIT25_23305	COG4209	transmembrane transport
LIT25_23310	COG0395	ABC-type sugar transport system, permease component
LIT25_23315	COG1653	transport
LIT25_23320	COG5578	integral membrane protein
LIT25_23330	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_23340	COG1464	Belongs to the NlpA lipoprotein family
LIT25_23345	COG2011	ABC-type metal ion transport system permease component
LIT25_23350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LIT25_23375	COG0561	phosphatase activity
LIT25_23385	COG3842	ATPase activity
LIT25_23420	COG2890	protein-(glutamine-N5) methyltransferase activity
LIT25_23460	COG0010	Belongs to the arginase family
LIT25_23465	COG1228	amidohydrolase
LIT25_23470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LIT25_23475	COG2986	histidine ammonia-lyase
LIT25_23485	COG3275	phosphorelay sensor kinase activity
LIT25_23490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LIT25_23495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LIT25_23500	COG0745	RESPONSE REGULATOR receiver
LIT25_23505	COG2770	Histidine kinase
LIT25_23505	COG2205	protein histidine kinase activity
LIT25_23535	COG1349	DNA-binding transcription factor activity
LIT25_23540	COG0805	protein transport
LIT25_23545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_23565	COG0114	fumarate hydratase activity
LIT25_23590	COG5002	protein histidine kinase activity
LIT25_23595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LIT25_23600	COG0446	pyridine nucleotide-disulphide oxidoreductase
LIT25_23615	COG0598	Magnesium transport protein CorA
LIT25_23620	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LIT25_23625	COG1131	(ABC) transporter
LIT25_23635	COG0741	lytic transglycosylase activity
LIT25_23655	COG1070	Carbohydrate kinase
LIT25_23660	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
LIT25_23680	COG1846	Transcriptional regulator
LIT25_23685	COG2814	Major facilitator Superfamily
LIT25_23695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIT25_23715	COG2176	DNA-directed DNA polymerase activity
LIT25_23725	COG0004	ammonium transporteR
LIT25_23730	COG0640	Transcriptional regulator
LIT25_23740	COG0753	catalase activity
LIT25_23750	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LIT25_23755	COG1131	(ABC) transporter
LIT25_23765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LIT25_23770	COG1309	transcriptional regulator
LIT25_23790	COG0730	response to heat
LIT25_23795	COG0425	Belongs to the sulfur carrier protein TusA family
LIT25_23800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_23800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LIT25_23805	COG0425	Belongs to the sulfur carrier protein TusA family
LIT25_23805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LIT25_23810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LIT25_23815	COG1054	Belongs to the UPF0176 family
LIT25_23820	COG2210	Belongs to the sulfur carrier protein TusA family
LIT25_23825	COG1937	Protein conserved in bacteria
LIT25_23840	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LIT25_23845	COG0557	exoribonuclease II activity
LIT25_23850	COG1647	Serine aminopeptidase, S33
LIT25_23855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LIT25_23860	COG0697	spore germination
LIT25_23970	COG4695	Portal protein
LIT25_23995	COG4974	Belongs to the 'phage' integrase family
LIT25_24000	COG0148	phosphopyruvate hydratase activity
LIT25_24020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LIT25_24025	COG2390	Transcriptional regulator
LIT25_24035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LIT25_24060	COG0740	serine-type endopeptidase activity
LIT25_24065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_24070	COG1481	regulation of sporulation
LIT25_24075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LIT25_24080	COG1660	Displays ATPase and GTPase activities
LIT25_24085	COG1051	belongs to the nudix hydrolase family
LIT25_24090	COG0492	ferredoxin-NADP+ reductase activity
LIT25_24095	COG0457	Tetratricopeptide repeat
LIT25_24105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LIT25_24105	COG0140	phosphoribosyl-ATP diphosphatase activity
LIT25_24110	COG0107	imidazoleglycerol-phosphate synthase activity
LIT25_24115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LIT25_24120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LIT25_24125	COG0131	Imidazoleglycerol-phosphate dehydratase
LIT25_24130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LIT25_24135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LIT25_24140	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LIT25_24145	COG0110	maltose O-acetyltransferase activity
LIT25_24150	COG0546	phosphoglycolate phosphatase activity
LIT25_24155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LIT25_24160	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LIT25_24175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LIT25_24180	COG1970	mechanosensitive ion channel activity
LIT25_24185	COG1950	PFAM Membrane protein of
LIT25_24195	COG3595	metallopeptidase activity
LIT25_24205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LIT25_24210	COG0556	nucleotide-excision repair
LIT25_24215	COG4897	Protein conserved in bacteria
LIT25_24220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LIT25_24225	COG3850	Histidine kinase
LIT25_24225	COG5002	protein histidine kinase activity
LIT25_24230	COG0745	RESPONSE REGULATOR receiver
LIT25_24235	COG0577	efflux transmembrane transporter activity
LIT25_24240	COG1136	(ABC) transporter
LIT25_24250	COG0109	protoheme IX farnesyltransferase activity
LIT25_24265	COG0789	Transcriptional regulator
LIT25_24270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LIT25_24280	COG0793	Belongs to the peptidase S41A family
LIT25_24280	COG3409	Peptidoglycan-binding domain 1 protein
LIT25_24285	COG0739	heme binding
LIT25_24290	COG2177	Part of the ABC transporter FtsEX involved in
LIT25_24295	COG2884	Cell division ATP-binding protein ftsE
LIT25_24300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LIT25_24300	COG2010	Cytochrome c
LIT25_24305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LIT25_24315	COG0653	protein targeting
LIT25_24320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LIT25_24335	COG1516	flagellar protein fliS
LIT25_24340	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LIT25_24345	COG1334	flagellar protein FlaG
LIT25_24350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LIT25_24355	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LIT25_24360	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
LIT25_24370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LIT25_24375	COG1256	bacterial-type flagellum assembly
LIT25_24375	COG4786	Flagellar basal body rod
LIT25_24380	COG3418	PFAM FlgN family protein
LIT25_24385	COG2747	anti-sigma28 factor FlgM
LIT25_24395	COG1040	competence protein
LIT25_24405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LIT25_24415	COG1307	EDD domain protein, DegV family
LIT25_24420	COG2197	response regulator
LIT25_24425	COG4585	Histidine kinase
LIT25_24430	COG1739	Uncharacterized protein family UPF0029
LIT25_24435	COG1316	TRANSCRIPTIONal
LIT25_24440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LIT25_24445	COG0297	glycogen (starch) synthase activity
LIT25_24455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LIT25_24460	COG0438	transferase activity, transferring glycosyl groups
LIT25_24465	COG1134	teichoic acid transport
LIT25_24465	COG1388	LysM domain
LIT25_24470	COG1682	transport, permease protein
LIT25_24475	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LIT25_24490	COG1216	Glycosyl transferase, family 2
LIT25_24500	COG1316	TRANSCRIPTIONal
LIT25_24505	COG1216	Glycosyl transferase, family 2
LIT25_24505	COG0463	Glycosyl transferase, family 2
LIT25_24525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LIT25_24530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LIT25_24535	COG2247	cell wall binding repeat
LIT25_24535	COG2385	sporulation resulting in formation of a cellular spore
LIT25_24545	COG0860	N-Acetylmuramoyl-L-alanine amidase
LIT25_24555	COG2247	cell wall binding repeat
LIT25_24555	COG2385	sporulation resulting in formation of a cellular spore
LIT25_24565	COG0791	NLP P60 protein
LIT25_24565	COG1388	LysM domain
LIT25_24575	COG1316	TRANSCRIPTIONal
LIT25_24580	COG0653	protein targeting
LIT25_24600	COG3618	amidohydrolase
LIT25_24615	COG0673	inositol 2-dehydrogenase activity
LIT25_24630	COG0395	ABC-type sugar transport system, permease component
LIT25_24635	COG4209	transmembrane transport
LIT25_24640	COG5578	integral membrane protein
LIT25_24645	COG2207	Transcriptional regulator
LIT25_24645	COG1917	Cupin 2, conserved barrel domain protein
LIT25_24675	COG3693	PFAM glycoside hydrolase, family 10
LIT25_24685	COG1349	DNA-binding transcription factor activity
LIT25_24695	COG1940	carbohydrate kinase activity
LIT25_24720	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_24725	COG1796	DNA polymerase
LIT25_24725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LIT25_24730	COG0395	ABC-type sugar transport system, permease component
LIT25_24735	COG1175	transmembrane transport
LIT25_24745	COG1609	Transcriptional regulator
LIT25_24750	COG1482	cell wall glycoprotein biosynthetic process
LIT25_24765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LIT25_24780	COG0438	transferase activity, transferring glycosyl groups
LIT25_24795	COG0728	peptidoglycan biosynthetic process
LIT25_24800	COG0438	transferase activity, transferring glycosyl groups
LIT25_24805	COG0438	transferase activity, transferring glycosyl groups
LIT25_24825	COG4464	protein tyrosine phosphatase activity
LIT25_24830	COG0489	protein tyrosine kinase activity
LIT25_24835	COG3944	biosynthesis protein
LIT25_24845	COG4715	Zinc finger, swim domain protein
LIT25_24850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LIT25_24855	COG0629	single-stranded DNA binding
LIT25_24890	COG4786	Flagellar basal body rod
LIT25_24895	COG4786	Flagellar basal body rod
LIT25_24900	COG1077	Cell shape determining protein MreB Mrl
LIT25_24905	COG1609	Transcriptional regulator
LIT25_24910	COG0739	heme binding
LIT25_24920	COG1247	-acetyltransferase
LIT25_24925	COG2385	sporulation resulting in formation of a cellular spore
LIT25_24935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LIT25_24945	COG4836	Membrane
LIT25_24950	COG1007	ATP synthesis coupled electron transport
LIT25_24955	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LIT25_24960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LIT25_24965	COG0713	ATP synthesis coupled electron transport
LIT25_24985	COG0649	NAD binding
LIT25_24990	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LIT25_24995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LIT25_25015	COG0673	inositol 2-dehydrogenase activity
LIT25_25020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LIT25_25045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LIT25_25050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LIT25_25055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LIT25_25060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LIT25_25065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LIT25_25070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LIT25_25080	COG0356	it plays a direct role in the translocation of protons across the membrane
LIT25_25095	COG1404	Belongs to the peptidase S8 family
LIT25_25100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LIT25_25110	COG1968	undecaprenyl-diphosphatase activity
LIT25_25115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LIT25_25125	COG0698	ribose 5-phosphate isomerase
LIT25_25135	COG1971	Probably functions as a manganese efflux pump
LIT25_25140	COG0009	L-threonylcarbamoyladenylate synthase
LIT25_25165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LIT25_25170	COG0346	lactoylglutathione lyase activity
LIT25_25175	COG0789	Transcriptional regulator
LIT25_25185	COG1435	thymidine kinase activity
LIT25_25190	COG0254	rRNA binding
LIT25_25195	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LIT25_25200	COG1494	fructose-1,6-bisphosphatase
LIT25_25205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LIT25_25210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LIT25_25215	COG0191	fructose-bisphosphate aldolase activity
LIT25_25220	COG2204	response regulator
LIT25_25225	COG4821	SIS domain
LIT25_25230	COG0504	CTP synthase activity
LIT25_25240	COG3853	Toxic anion resistance protein (TelA)
LIT25_25280	COG2310	stress, protein
LIT25_25285	COG2310	stress, protein
LIT25_25295	COG1703	isobutyryl-CoA mutase activity
LIT25_25295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIT25_25295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIT25_25305	COG1960	acyl-CoA dehydrogenase activity
LIT25_25310	COG1960	acyl-CoA dehydrogenase activity
LIT25_25315	COG1250	3-hydroxyacyl-CoA dehydrogenase
LIT25_25320	COG0183	Belongs to the thiolase family
LIT25_25325	COG2181	nitrate reductase activity
LIT25_25325	COG0247	lactate metabolic process
LIT25_25330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LIT25_25335	COG4294	response to UV
LIT25_25340	COG0018	arginyl-trna synthetase
LIT25_25345	COG4506	Protein conserved in bacteria
LIT25_25350	COG0010	Belongs to the arginase family
LIT25_25355	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LIT25_25360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LIT25_25370	COG1994	Peptidase M50
LIT25_25380	COG3465	dGTPase activity
LIT25_25385	COG1078	dGTPase activity
LIT25_25390	COG4844	belongs to the
LIT25_25405	COG0280	phosphate acetyltransferase
LIT25_25410	COG3253	May function as heme-dependent peroxidase
LIT25_25430	COG2363	Small membrane protein
LIT25_25460	COG0300	oxidoreductase activity
LIT25_25465	COG1216	Glycosyl transferase, family 2
LIT25_25490	COG0351	phosphomethylpyrimidine kinase
LIT25_25495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LIT25_25500	COG2059	Chromate
LIT25_25505	COG2059	Chromate
LIT25_25515	COG1522	sequence-specific DNA binding
LIT25_25525	COG0778	Nitroreductase
LIT25_25530	COG3314	Sporulation integral membrane protein YlbJ
LIT25_25545	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LIT25_25550	COG1845	cytochrome c oxidase, subunit III
LIT25_25555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LIT25_25595	COG0488	(ABC) transporter
LIT25_25605	COG0789	Transcriptional regulator
LIT25_25620	COG2124	cytochrome p450
LIT25_25630	COG4895	conserved protein (DUF2196)
LIT25_25650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_25655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LIT25_25695	COG1511	domain protein
LIT25_25700	COG1674	ftsk spoiiie
LIT25_25700	COG0433	COG0433 Predicted ATPase
LIT25_25705	COG4499	WXG100 protein secretion system (Wss), protein YukC
LIT25_25710	COG5417	Belongs to the EsaB family
LIT25_25715	COG4842	Belongs to the WXG100 family
LIT25_25755	COG2094	Belongs to the DNA glycosylase MPG family
LIT25_25760	COG2207	Transcriptional regulator
LIT25_25765	COG0673	inositol 2-dehydrogenase activity
LIT25_25775	COG2195	Cleaves the N-terminal amino acid of tripeptides
LIT25_25780	COG3842	ATPase activity
LIT25_25785	COG1176	ABC-type spermidine putrescine transport system, permease component I
LIT25_25795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LIT25_25800	COG0326	Molecular chaperone. Has ATPase activity
LIT25_25805	COG1846	Transcriptional regulator
LIT25_25815	COG0745	RESPONSE REGULATOR receiver
LIT25_25820	COG2205	protein histidine kinase activity
LIT25_25825	COG1136	(ABC) transporter
LIT25_25830	COG0577	efflux transmembrane transporter activity
LIT25_25855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LIT25_25860	COG0697	spore germination
LIT25_25865	COG0662	Cupin 2, conserved barrel domain protein
LIT25_25865	COG2207	Transcriptional regulator
LIT25_25870	COG1404	Belongs to the peptidase S8 family
LIT25_25875	COG2814	Major facilitator Superfamily
LIT25_25895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LIT25_25900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LIT25_25905	COG4853	Protein conserved in bacteria
LIT25_25915	COG5002	protein histidine kinase activity
LIT25_25920	COG0745	RESPONSE REGULATOR receiver
LIT25_25925	COG0739	heme binding
LIT25_25935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LIT25_25940	COG0305	Participates in initiation and elongation during chromosome replication
LIT25_25945	COG0359	binds to the 23S rRNA
LIT25_25950	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LIT25_25955	COG4241	membrane
LIT25_25960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LIT25_25965	COG0629	single-stranded DNA binding
LIT25_25970	COG0360	Binds together with S18 to 16S ribosomal RNA
LIT25_25975	COG0012	GTP binding
LIT25_25980	COG4481	Protein conserved in bacteria
LIT25_25985	COG0668	transmembrane transport
LIT25_26000	COG1475	DNA binding
LIT25_26005	COG1192	Involved in chromosome partitioning
LIT25_26020	COG0445	tRNA wobble uridine modification
LIT25_26025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LIT25_26030	COG1847	R3H domain protein
LIT25_26035	COG0706	membrane insertase activity
LIT25_26040	COG0594	ribonuclease P activity
LIT25_26055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LIT25_26055	COG2755	lipolytic protein G-D-S-L family
LIT25_26060	COG1595	DNA-templated transcription, initiation
LIT25_26070	COG0574	Belongs to the PEP-utilizing enzyme family
LIT25_26070	COG3848	Pyruvate phosphate dikinase
LIT25_26075	COG0574	Belongs to the PEP-utilizing enzyme family
LIT25_26075	COG3848	Pyruvate phosphate dikinase
LIT25_26120	COG2226	methyltransferase
LIT25_26130	COG2309	aminopeptidase activity
LIT25_26150	COG0028	Belongs to the TPP enzyme family
LIT25_26165	COG3547	Transposase (IS116 IS110 IS902 family)
LIT25_26185	COG0531	amino acid
LIT25_26200	COG2323	membrane
LIT25_26240	COG1404	Belongs to the peptidase S8 family
LIT25_26245	COG2003	Belongs to the UPF0758 family
LIT25_26260	COG2972	Histidine kinase
LIT25_26265	COG4753	response regulator
LIT25_26265	COG2207	Transcriptional regulator
LIT25_26275	COG1175	transmembrane transport
LIT25_26285	COG3537	Alpha-1,2-mannosidase
LIT25_26290	COG1609	Transcriptional regulator
LIT25_26300	COG5434	Belongs to the glycosyl hydrolase 28 family
LIT25_26305	COG1129	ABC transporter
LIT25_26310	COG1172	Belongs to the binding-protein-dependent transport system permease family
LIT25_26325	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_26340	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_26350	COG4154	Belongs to the RbsD FucU family
LIT25_26385	COG4412	M6 family metalloprotease domain protein
LIT25_26385	COG1404	Belongs to the peptidase S8 family
LIT25_26390	COG0156	8-amino-7-oxononanoate synthase activity
LIT25_26410	COG3540	Alkaline phosphatase
LIT25_26430	COG1349	DNA-binding transcription factor activity
LIT25_26445	COG0039	L-malate dehydrogenase activity
LIT25_26450	COG1620	l-lactate permease
LIT25_26460	COG0584	glycerophosphoryl diester phosphodiesterase
LIT25_26465	COG2188	Transcriptional regulator
LIT25_26490	COG1349	DNA-binding transcription factor activity
LIT25_26555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_26590	COG1404	Belongs to the peptidase S8 family
LIT25_26610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIT25_26610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_26615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_26625	COG3716	PTS system mannose fructose sorbose family IID component
LIT25_26630	COG2188	Transcriptional regulator
LIT25_26675	COG0601	transmembrane transport
LIT25_26680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LIT25_26730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_26740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LIT25_26745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_26750	COG0346	lactoylglutathione lyase activity
LIT25_26760	COG2207	Transcriptional regulator
LIT25_26765	COG4209	transmembrane transport
LIT25_26770	COG0395	ABC-type sugar transport system, permease component
LIT25_26775	COG1653	transport
LIT25_26785	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LIT25_26795	COG5578	integral membrane protein
LIT25_26800	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LIT25_26805	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_26820	COG2964	Protein conserved in bacteria
LIT25_26825	COG0251	oxidation-reduction process
LIT25_26830	COG2271	Major facilitator Superfamily
LIT25_26875	COG1733	regulation of RNA biosynthetic process
LIT25_26885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIT25_26890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LIT25_26915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LIT25_26915	COG2207	Transcriptional regulator
LIT25_26920	COG4209	transmembrane transport
LIT25_26925	COG0395	ABC-type sugar transport system, permease component
LIT25_26940	COG3507	Belongs to the glycosyl hydrolase 43 family
LIT25_26945	COG0366	Alpha amylase catalytic
LIT25_26945	COG1470	cell adhesion involved in biofilm formation
LIT25_26970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_27015	COG2801	Transposase and inactivated derivatives
LIT25_27025	COG1404	Belongs to the peptidase S8 family
LIT25_27075	COG1609	Transcriptional regulator
LIT25_27085	COG1840	ABC-type Fe3 transport system, periplasmic component
LIT25_27090	COG3842	ATPase activity
LIT25_27095	COG1178	ABC-type Fe3 transport system permease component
LIT25_27130	COG3540	Alkaline phosphatase
LIT25_27145	COG0589	response to stress
LIT25_27165	COG2205	protein histidine kinase activity
LIT25_27170	COG0745	RESPONSE REGULATOR receiver
LIT25_27205	COG2201	protein-glutamate methylesterase activity
LIT25_27215	COG1131	(ABC) transporter
LIT25_27245	COG1252	NADH dehydrogenase
LIT25_27285	COG3177	Filamentation induced by cAMP protein fic
LIT25_27290	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
LIT25_27295	COG0385	Bile acid
LIT25_27345	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_27350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LIT25_27355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LIT25_27360	COG1028	Short-chain dehydrogenase reductase Sdr
LIT25_27365	COG4187	Peptidase family M20/M25/M40
LIT25_27370	COG0436	Aminotransferase
LIT25_27390	COG0765	amino acid transport
LIT25_27395	COG1126	abc transporter atp-binding protein
LIT25_27405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LIT25_27410	COG0477	Major facilitator Superfamily
LIT25_27435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LIT25_27440	COG0444	Belongs to the ABC transporter superfamily
LIT25_27445	COG4608	Belongs to the ABC transporter superfamily
LIT25_27450	COG4948	Mandelate Racemase Muconate Lactonizing
LIT25_27460	COG1473	amidohydrolase
LIT25_27465	COG1506	peptidase
LIT25_27465	COG4946	Tricorn protease homolog
LIT25_27465	COG0823	Involved in the tonB-independent uptake of proteins
LIT25_27470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LIT25_27485	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LIT25_27495	COG1609	Transcriptional regulator
LIT25_27500	COG1653	transport
LIT25_27505	COG1175	transmembrane transport
LIT25_27510	COG0395	ABC-type sugar transport system, permease component
LIT25_27515	COG0366	Alpha amylase catalytic
LIT25_27525	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
LIT25_27535	COG1063	alcohol dehydrogenase
LIT25_27545	COG1940	carbohydrate kinase activity
LIT25_27550	COG1482	cell wall glycoprotein biosynthetic process
LIT25_27615	COG3192	ethanolamine utilization protein
LIT25_27620	COG0006	proline dipeptidase activity
LIT25_27625	COG0006	proline dipeptidase activity
LIT25_27630	COG2204	response regulator
LIT25_27650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LIT25_27655	COG0569	domain protein
LIT25_27660	COG0598	Magnesium transport protein CorA
LIT25_27670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIT25_27755	COG1940	carbohydrate kinase activity
LIT25_27760	COG2971	BadF BadG BcrA BcrD
LIT25_27765	COG0165	Argininosuccinate lyase
LIT25_27780	COG3842	ATPase activity
LIT25_27790	COG1940	carbohydrate kinase activity
LIT25_27790	COG1846	Transcriptional regulator
LIT25_27800	COG3483	tryptophan 2,3-dioxygenase activity
LIT25_27805	COG1113	amino acid transport
LIT25_27810	COG3844	kynureninase activity
LIT25_27825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LIT25_27830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LIT25_27835	COG1012	belongs to the aldehyde dehydrogenase family
LIT25_27845	COG1414	Transcriptional regulator
LIT25_27870	COG1309	transcriptional regulator
LIT25_27890	COG3971	2-oxopent-4-enoate hydratase activity
LIT25_27900	COG0251	oxidation-reduction process
LIT25_27920	COG0431	NADPH-dependent FMN reductase
LIT25_27925	COG0196	riboflavin kinase activity
LIT25_27930	COG2368	4-hydroxyphenylacetate
LIT25_27935	COG2814	Major facilitator Superfamily
LIT25_28010	COG3711	transcriptional antiterminator
LIT25_28015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LIT25_28015	COG1263	PTS System
LIT25_28025	COG1937	Protein conserved in bacteria
LIT25_28030	COG0534	Mate efflux family protein
LIT25_28050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LIT25_28055	COG1122	ATPase activity
LIT25_28060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LIT25_28070	COG1288	antiporter activity
LIT25_28075	COG1473	amidohydrolase
LIT25_28100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family