locus-tag class description A6J74_00085 ENOG4105D29 Helix-turn-helix type 11 domain protein A6J74_00470 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A6J74_00475 ENOG4108ZHR arsR family transcriptional regulator A6J74_00480 ENOG4108SQ9 flavin reductase domain protein, FMN-binding A6J74_00515 ENOG4105D4Y metalloprotease A6J74_00525 ENOG4105DU0 nucleoside hydrolase A6J74_00550 ENOG4105CJ1 ABC, transporter A6J74_00565 ENOG4108KF3 Electron transport protein SCO1 SenC A6J74_00570 ENOG4106048 Cupin 2, conserved barrel domain protein A6J74_00580 ENOG4105CYW agmatinase A6J74_00585 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) A6J74_00590 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A6J74_00600 ENOG4105MWK D-amino acid dehydrogenase, small subunit A6J74_00605 ENOG4105KD7 acetyltransferase A6J74_00635 ENOG4108MRH transcriptional regulatory protein A6J74_00675 ENOG4105CH6 catalase A6J74_00695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_00705 ENOG4105D7V transposase A6J74_00730 ENOG4105C19 ABC transporter A6J74_00750 ENOG4108B31 Spore germination protein A6J74_00780 ENOG41085FC arsR family transcriptional regulator A6J74_00785 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_00790 ENOG4105D6J arsenicaL-resistance protein A6J74_00805 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A6J74_00830 ENOG4108D32 Methyltransferase A6J74_00840 ENOG4108IUW ABC transporter A6J74_00860 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase A6J74_00865 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) A6J74_00870 ENOG4105EUJ GTP cyclohydrolase i A6J74_00940 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) A6J74_00945 ENOG4105FQP Beta-lactamase A6J74_00960 ENOG4105ED2 Beta-lactamase A6J74_00965 ENOG4105GZI Transcriptional regulator A6J74_01010 ENOG4105BZU Histidine kinase A6J74_01020 ENOG4108UHE carbonic anhydrase A6J74_01040 ENOG4105EXC Acyl-transferase A6J74_01050 ENOG4107VMI polysaccharide deacetylase A6J74_01055 ENOG4105DCF alanine dehydrogenase A6J74_01060 ENOG4108K8K Transcriptional regulator A6J74_01130 ENOG4108VJ1 Transcriptional regulator (CarD family A6J74_01230 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A6J74_01235 ENOG4105BZ1 (ABC) transporter A6J74_01305 ENOG4105KIR Thiol-disulfide oxidoreductase dcc A6J74_01405 ENOG4105D7V transposase A6J74_01455 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A6J74_01480 ENOG4105D7V transposase A6J74_01565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A6J74_01595 ENOG41068WN A6J74_01620 ENOG4105VMP Transcriptional regulator A6J74_01630 ENOG4105E98 transcriptional regulator DeoR family A6J74_01635 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component A6J74_01670 ENOG4105G6Z alkaline phosphatase A6J74_01675 ENOG4107RBI VanW family A6J74_01680 ENOG4105ECK Fatty Acid Desaturase A6J74_01700 ENOG4107258 Transcriptional regulator A6J74_01710 ENOG4105II7 pyrroline-5-carboxylate reductase A6J74_01720 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A6J74_01725 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) A6J74_01735 ENOG41075H3 AraC family transcriptional regulator A6J74_01740 ENOG4107QK4 glycoside hydrolase, family 3 domain protein A6J74_01760 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) A6J74_01780 ENOG41061GT Aldolase A6J74_01790 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) A6J74_01795 ENOG4105DKT Transcriptional regulator A6J74_01805 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane A6J74_01810 ENOG4105F5R ABC transporter A6J74_01815 ENOG4105D4B ABC, transporter A6J74_01835 ENOG4108YYH Nadph-dependent fmn reductase A6J74_01840 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A6J74_01845 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_01855 ENOG41069ER domain protein A6J74_01900 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A6J74_01935 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) A6J74_01940 ENOG41082JN Transcriptional regulator A6J74_01945 ENOG4105EYF MMPL domain protein A6J74_01950 ENOG4105C5H ABC transporter A6J74_01960 ENOG4108ZCF integral membrane protein A6J74_01965 ENOG4105C0R drug resistance transporter emrb qaca subfamily A6J74_01980 ENOG4107VMI polysaccharide deacetylase A6J74_01995 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_02000 ENOG4105C6T cysteine synthase A6J74_02070 ENOG4108AQF aminoglycoside N(3)-acetyltransferase A6J74_02095 ENOG4105D7T ABC transporter A6J74_02100 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein A6J74_02105 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component A6J74_02110 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) A6J74_02125 ENOG4105C02 permease A6J74_02175 ENOG4105DVE abc transporter atp-binding protein A6J74_02190 ENOG4108ZMI UPF0477 protein A6J74_02205 ENOG4105CHM Aminotransferase A6J74_02245 ENOG41089UC methyltransferase, type 11 A6J74_02260 ENOG4107BMA Transglycosylase associated protein A6J74_02285 ENOG4106K7D Major facilitator family transporter A6J74_02290 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) A6J74_02360 ENOG4105EPR degv family A6J74_02365 ENOG4105KEG ribosomal-protein-alanine acetyltransferase A6J74_02370 ENOG4105DPN Oligoendopeptidase f A6J74_02375 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 A6J74_02395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_02400 ENOG4105BZU Histidine kinase A6J74_02405 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) A6J74_02455 ENOG4105DTQ mandelate racemase muconate lactonizing A6J74_02470 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A6J74_02485 ENOG4107T5V SNARE associated Golgi A6J74_02490 ENOG4105DCI Phosphohydrolase A6J74_02530 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein A6J74_02540 ENOG41080HI glycine oxidase A6J74_02545 ENOG4105CTU Proline racemase A6J74_02550 ENOG4105CTU Proline racemase A6J74_02555 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A6J74_02560 ENOG4105C26 Dehydrogenase A6J74_02565 ENOG4105BZG amino acid carrier protein A6J74_02575 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A6J74_02595 ENOG4108M1A Chitin-binding protein A6J74_02640 ENOG4105C9U ATP-dependent DNA helicase RecQ A6J74_02650 ENOG4105EEM helicase A6J74_02675 ENOG4108Z7F N-acetyltransferase A6J74_02700 ENOG4105MSB protein, conserved in bacteria A6J74_02705 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A6J74_02720 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A6J74_02730 ENOG41087PP glycosyltransferase MGT family A6J74_02740 ENOG4108M1A Chitin-binding protein A6J74_02755 ENOG41082BV acetyltransferase A6J74_02775 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A6J74_02785 ENOG4108IJ7 Glycine betaine A6J74_02790 ENOG4107SQ8 Glycine betaine A6J74_02820 ENOG4105E1F short-chain dehydrogenase reductase A6J74_02830 ENOG4107RUY (E1 component), alpha subunit A6J74_02840 ENOG4107QKR Dehydrogenase A6J74_02870 ENOG4105E98 transcriptional regulator DeoR family A6J74_02890 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family A6J74_02900 ENOG4107Z3H Transcriptional regulator, TetR family A6J74_02940 ENOG4105MSI germination protein ypeb A6J74_02990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A6J74_02995 ENOG4105FDR Membrane A6J74_03000 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A6J74_03010 ENOG4105CGH 5'-nucleotidase A6J74_03020 ENOG4108IUM Glycogen debranching enzyme A6J74_03040 ENOG4105DY8 decarboxylase A6J74_03065 ENOG4107WD8 ABC transporter, permease A6J74_03110 ENOG4105BZU Histidine kinase A6J74_03115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_03120 ENOG4105U0R haloacid dehalogenase-like hydrolase A6J74_03145 ENOG4107VFR oxidoreductase A6J74_03175 ENOG4105PKS Excinuclease abc c subunit domain protein A6J74_03200 ENOG4108YYS metal-dependent hydrolase (By similarity) A6J74_03210 ENOG4105KWG Pfam:DUF1696 A6J74_03215 ENOG4108NRW Phospholipase, patatin family A6J74_03240 ENOG4108XI2 Domain of unknown function (DUF1963) A6J74_03265 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A6J74_03270 ENOG4105E09 nadh pyrophosphatase A6J74_03280 ENOG4105FCD Major Facilitator A6J74_03320 ENOG4107Y9U Membrane A6J74_03345 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A6J74_03365 ENOG4107SFI Major Facilitator superfamily A6J74_03430 ENOG4105CJN penicillin-binding protein A6J74_03435 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase A6J74_03440 ENOG4105CB2 alcohol dehydrogenase A6J74_03455 ENOG4108HGU Histidine kinase A6J74_03470 ENOG4108JJB ABC transporter A6J74_03495 ENOG4107RF6 penicillin-binding protein A6J74_03500 ENOG4105BZU Histidine kinase A6J74_03510 ENOG410667J hydrolase A6J74_03610 ENOG4108IBT Inherit from COG: transposase A6J74_03630 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A6J74_03715 ENOG4105CAR Terminase, large subunit A6J74_03750 ENOG410682Q Phage transcriptional regulator, ArpU A6J74_03815 ENOG4106CVF DNA replication protein A6J74_03860 ENOG4105VTR Integrase A6J74_04055 ENOG4105ETU transcriptional activator (TenA A6J74_04070 ENOG4105D6E homoserine dehydrogenase A6J74_04115 ENOG4105CPC Aldo Keto reductase A6J74_04120 ENOG4106NZI LysR family Transcriptional regulator A6J74_04155 ENOG4105DK7 lysyl-tRNA synthetase A6J74_04165 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein A6J74_04175 ENOG4108V4B ThiJ pfpI A6J74_04185 ENOG410900G Protein of unknown function (DUF421) A6J74_04215 ENOG4105SX7 Transporter A6J74_04230 ENOG4105CUV Homoserine Kinase A6J74_04240 ENOG4105CR8 Transcriptional regulator A6J74_04245 ENOG4105MDS 4-oxalocrotonate tautomerase A6J74_04255 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) A6J74_04265 ENOG41089UC methyltransferase, type 11 A6J74_04270 ENOG4105KVH Transcriptional regulator A6J74_04275 ENOG4107EXU Short-chain dehydrogenase reductase Sdr A6J74_04285 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A6J74_04315 ENOG41075H3 AraC family transcriptional regulator A6J74_04345 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) A6J74_04355 ENOG4105T9C HD domain A6J74_04440 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A6J74_04445 ENOG4107QX3 carboxylase A6J74_04450 ENOG4105E39 Enoyl-CoA hydratase A6J74_04455 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A6J74_04460 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit A6J74_04465 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A6J74_04470 ENOG4105C1G acyl-Coa dehydrogenase A6J74_04480 ENOG4107Z3H Transcriptional regulator, TetR family A6J74_04490 ENOG4105CJ1 ABC, transporter A6J74_04515 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C A6J74_04520 ENOG4108M1A Chitin-binding protein A6J74_04580 ENOG4107RF6 penicillin-binding protein A6J74_04585 ENOG4107RF6 penicillin-binding protein A6J74_04600 ENOG4107RVG penicillin-binding protein A6J74_04625 ENOG4105EQK -acetyltransferase A6J74_04630 ENOG4105EJ9 Membrane A6J74_04640 ENOG4105KRN Transcriptional regulator, abrb family A6J74_04670 ENOG4105CIN aminoacyl-histidine dipeptidase A6J74_04700 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A6J74_04710 ENOG4107RA9 decarboxylase A6J74_04715 ENOG4108I0C methyltransferase A6J74_04730 ENOG4105C1J atp-dependent rna helicase A6J74_04745 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A6J74_04770 ENOG4107STF Involved in phosphonate degradation (By similarity) A6J74_04780 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A6J74_04785 ENOG4105RD7 BadF BadG BcrA BcrD A6J74_04790 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) A6J74_04810 ENOG4105F32 YngK protein A6J74_04835 ENOG4108KPJ rna polymerase sigma factor A6J74_04875 ENOG4108JCI Transcriptional regulator A6J74_04880 ENOG4108VP3 Lysine exporter protein (LysE YggA) A6J74_04890 ENOG4105BZ1 (ABC) transporter A6J74_04895 ENOG4105BZ1 (ABC) transporter A6J74_04910 ENOG4108RPX mosc domain containing protein A6J74_04915 ENOG4108JPW Aminotransferase A6J74_04920 ENOG4105DND Transcriptional regulator A6J74_04925 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A6J74_04930 ENOG4107V2S Transcriptional regulator A6J74_04960 ENOG41068WN A6J74_04970 ENOG4105C1Q protoporphyrinogen oxidase A6J74_04995 ENOG4105WCN acetyltransferase A6J74_05015 ENOG4105EYF MMPL domain protein A6J74_05020 ENOG41067SE Tetr family transcriptional regulator A6J74_05025 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) A6J74_05035 ENOG4107MII Sugar-specific transcriptional regulator TrmB A6J74_05055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_05065 ENOG4105BZU Histidine kinase A6J74_05080 ENOG4105EXC Acyl-transferase A6J74_05105 ENOG41075H3 AraC family transcriptional regulator A6J74_05115 ENOG4108Y4K DNA-binding transcriptional activator A6J74_05125 ENOG41081I9 integral membrane protein A6J74_05140 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) A6J74_05165 ENOG4107SKW Inherit from COG: Alpha beta hydrolase A6J74_05175 ENOG4105C19 ABC transporter A6J74_05180 ENOG4105C22 threonyL-tRNA synthetase A6J74_05185 ENOG4105FE9 pseudouridine synthase A6J74_05205 ENOG4105BZG amino acid carrier protein A6J74_05240 ENOG4105K70 DNA-binding protein A6J74_05255 ENOG4105C0R drug resistance transporter emrb qaca subfamily A6J74_05260 ENOG4105WQT MbtH domain protein A6J74_05265 ENOG4105CEY Amp-dependent synthetase and ligase A6J74_05270 ENOG4105WQI isochorismatase A6J74_05275 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase A6J74_05280 ENOG4105E4F Isochorismate synthase A6J74_05285 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase A6J74_05290 ENOG4105FCD Major Facilitator A6J74_05325 ENOG4107RFY SbcCD D subunit A6J74_05340 ENOG4105E39 Enoyl-CoA hydratase A6J74_05345 ENOG4105N14 lysine exporter protein LysE YggA A6J74_05355 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A6J74_05360 ENOG4105C1G acyl-Coa dehydrogenase A6J74_05365 ENOG4105CR4 methylisocitrate lyase A6J74_05370 ENOG4105DXD 2-methylcitrate dehydratase A6J74_05385 ENOG4105CZM Major Facilitator A6J74_05395 ENOG4105BZ4 penicillin-binding protein A6J74_05415 ENOG4105CHR reductase A6J74_05440 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A6J74_05495 ENOG4105SZ6 Thioredoxin A6J74_05505 ENOG410841Q phosphoesterase PA-phosphatase related protein A6J74_05550 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein A6J74_05555 ENOG4108JUB Transcriptional regulator A6J74_05560 ENOG4108TSC N-acetyltransferase A6J74_05565 ENOG4107S4Y M20 DapE family protein YgeY A6J74_05580 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A6J74_05610 ENOG4105C37 (CBS) domain A6J74_05645 ENOG4105E90 ABC transporter A6J74_05650 ENOG4108IJ8 ABC transporter A6J74_05680 ENOG4108YV3 Protein of unknown function (DUF2711) A6J74_05690 ENOG4105C6Z Gluconate A6J74_05695 ENOG4105CMG Carbohydrate kinase A6J74_05730 ENOG4106KNT transcriptional regulator A6J74_05735 ENOG4105WH1 Two component transcriptional regulator luxr family A6J74_05740 ENOG4105BZU Histidine kinase A6J74_05745 ENOG4105D8X mechanosensitive ion channel A6J74_05775 ENOG4105F0I Aminotransferase A6J74_05780 ENOG4108MES Periplasmic binding protein A6J74_05785 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A6J74_05800 ENOG4105CAQ asparagine synthetase A6J74_05805 ENOG4107Y70 Heat shock protein A6J74_05810 ENOG4108KF3 Electron transport protein SCO1 SenC A6J74_05815 ENOG4105E8R UPF0173 metal-dependent hydrolase A6J74_05820 ENOG4108RCR degv family A6J74_05830 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A6J74_05840 ENOG4108UT2 hemolysin iii A6J74_05845 ENOG4105E9Q Acyl-transferase A6J74_05855 ENOG4107RVG penicillin-binding protein A6J74_05870 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) A6J74_05885 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 A6J74_05900 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase A6J74_05905 ENOG4105KD7 acetyltransferase A6J74_05925 ENOG4105CY2 Citrate transporter A6J74_05930 ENOG4107XGZ Hydrolase A6J74_05950 ENOG4105C8J )-transporter A6J74_05955 ENOG4105C5S asparaginyl-tRNA synthetase A6J74_05975 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A6J74_05990 ENOG4105C75 arginyL-tRNA synthetase A6J74_05995 ENOG4107YX5 Pfam:DUF548 A6J74_06025 ENOG4108UUM single-stranded DNA-binding protein A6J74_06040 ENOG4105C5H ABC transporter A6J74_06055 ENOG4105MCT stage V sporulation protein S A6J74_06095 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) A6J74_06100 ENOG4105D9U N-acetyltransferase A6J74_06145 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) A6J74_06150 ENOG4108IFG nitrite reductase, (NAD(P)H) A6J74_06155 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit A6J74_06160 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A6J74_06165 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A6J74_06195 ENOG4108ZAF Molybdopterin A6J74_06200 ENOG4105CVM Molybdenum cofactor synthesis domain protein A6J74_06205 ENOG4105D06 uba thif-type nad fad binding protein A6J74_06210 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A6J74_06215 ENOG4107V6Q Cyclic nucleotide-binding domain A6J74_06225 ENOG4105R3A Nitrate reductase A6J74_06230 ENOG4108IUE nitrate reductase beta subunit A6J74_06240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A6J74_06255 ENOG4108V06 Glutathione peroxidase A6J74_06265 ENOG4105CNW domain protein A6J74_06285 ENOG4105EMN RNA polymerase sigma factor A6J74_06290 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein A6J74_06300 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily A6J74_06320 ENOG4108KQJ Type 11 methyltransferase A6J74_06345 ENOG4105KBJ sporulation protein ytfj A6J74_06355 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A6J74_06510 ENOG4108MGT Required for secretion of EsxA and EsxB A6J74_06515 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) A6J74_06525 ENOG4106PAW secretion accessory protein EsaA YueB A6J74_06545 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A6J74_06570 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A6J74_06575 ENOG4108JYZ YitT family A6J74_06580 ENOG41087PP glycosyltransferase MGT family A6J74_06595 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A6J74_06605 ENOG4105D94 Major Facilitator Superfamily A6J74_06610 ENOG41082F9 transcriptional regulator A6J74_06615 ENOG4108X4Q Hydrolase A6J74_06625 ENOG4108ZRV stage ii sporulation protein p A6J74_06645 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A6J74_06655 ENOG4108VXD carboxy-peptidase A6J74_06670 ENOG4108ZRV stage ii sporulation protein p A6J74_06690 ENOG4108Z7R Chaperone CsaA A6J74_06710 ENOG4105C37 (CBS) domain A6J74_06715 ENOG4105SXS Protein of unknown function (DUF456) A6J74_06735 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A6J74_06745 ENOG4108S4H thioesterase Superfamily protein A6J74_06755 ENOG4108PJD permease A6J74_06770 ENOG4107T5V SNARE associated Golgi A6J74_06790 ENOG4107TB6 phosphoglycerate mutase A6J74_06805 ENOG4108J59 Extracellular solute-binding protein, family 5 A6J74_06815 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A6J74_06825 ENOG4105K4T epimerase A6J74_06835 ENOG4105DSE periplasmic solute binding protein A6J74_06845 ENOG4105CKI cobalamin synthesis protein A6J74_06850 ENOG4107QM2 Aldo Keto reductase A6J74_06855 ENOG4105VMI -acetyltransferase A6J74_06870 ENOG4105DEN Luciferase family A6J74_06885 ENOG4108WPJ Ferritin-like domain A6J74_06895 ENOG4108K88 Membrane A6J74_06940 ENOG4105CPC Aldo Keto reductase A6J74_06945 ENOG4105YVS arsR family transcriptional regulator A6J74_06955 ENOG4105KRN Transcriptional regulator, abrb family A6J74_07005 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A6J74_07010 ENOG4108ZUB Lysine exporter protein (Lyse ygga) A6J74_07020 ENOG4105YWU small acid-soluble spore protein A6J74_07025 ENOG4108WBH protein TIM barrel A6J74_07040 ENOG4105CEY Amp-dependent synthetase and ligase A6J74_07045 ENOG4105DUU IucA IucC family protein A6J74_07055 ENOG4105VRR gCN5-related N-acetyltransferase A6J74_07060 ENOG4105KT7 mgtC SapB transporter A6J74_07070 ENOG4107VMI polysaccharide deacetylase A6J74_07075 ENOG4105BZU Histidine kinase A6J74_07080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A6J74_07090 ENOG4108KGH TRANSCRIPTIONal A6J74_07105 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) A6J74_07115 ENOG4105D6E homoserine dehydrogenase A6J74_07130 ENOG4106AKJ A6J74_07135 ENOG4108ZJ4 polysaccharide deacetylase A6J74_07140 ENOG41075D4 Aminoglycoside 6-adenylyltransferase A6J74_07160 ENOG4105BZU Histidine kinase A6J74_07165 ENOG4105EFI regulatoR A6J74_07170 ENOG4105BZ1 (ABC) transporter A6J74_07215 ENOG4105K64 Glycosyl transferase, family 2 A6J74_07220 ENOG4108JJ8 (ABC) transporter A6J74_07225 ENOG4108JJ9 ABC, transporter A6J74_07230 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A6J74_07235 ENOG4105C4M (Ubiquinol oxidase) subunit I A6J74_07260 ENOG4105EGI Transcriptional regulator A6J74_07270 ENOG4105C32 Amino acid ABC transporter (Permease) A6J74_07275 ENOG4108IV0 ABC, transporter A6J74_07280 ENOG4105C0Z ABC transporter A6J74_07290 ENOG4105CKI cobalamin synthesis protein A6J74_07300 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A6J74_07310 ENOG4106F5Q Membrane A6J74_07315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A6J74_07325 ENOG4108TVJ Nitroreductase A6J74_07330 ENOG4107ZXU DSBA oxidoreductase A6J74_07335 ENOG4108Z40 Transcriptional regulator A6J74_07340 ENOG4105GZI Transcriptional regulator A6J74_07345 ENOG4107RT3 EamA-like transporter family A6J74_07350 ENOG4105KTB nuclear export factor GLE1 A6J74_07355 ENOG4108T5E Copper resistance protein A6J74_07385 ENOG4105C5Q Transcriptional regulator A6J74_07425 ENOG4105F6J Alpha beta hydrolase fold A6J74_07455 ENOG41076HS cation diffusion facilitator family transporter A6J74_07465 ENOG4105CJW magnesium transporter A6J74_07470 ENOG4105CNI cell division protein FtsW A6J74_07505 ENOG4105CJZ response regulator A6J74_07535 ENOG4105C44 Serine transporter A6J74_07540 ENOG4105EJQ L-serine dehydratase A6J74_07595 ENOG4105F6J Alpha beta hydrolase fold A6J74_07605 ENOG4107R16 Multicopper oxidase A6J74_07610 ENOG4107RAQ aminopeptidase A6J74_07625 ENOG410811B TRANSCRIPTIONal A6J74_07655 ENOG4105KG3 cytidine deaminase A6J74_07660 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) A6J74_07665 ENOG4105D9N nucleoside A6J74_07675 ENOG4107RHR regulatoR A6J74_07715 ENOG4105C0X amino acid A6J74_07720 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) A6J74_07735 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) A6J74_07755 ENOG41068WN A6J74_07785 ENOG4105K5X acetyltransferase A6J74_07790 ENOG4107X42 5-methylthioadenosine S-adenosylhomocysteine nucleosidase A6J74_07800 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b A6J74_07805 ENOG4105C6X Major Facilitator A6J74_07830 ENOG4105C7B Threonine dehydratase A6J74_07840 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A6J74_07850 ENOG4105C7K acetolactate synthase A6J74_07855 ENOG4105CM2 brancheD-chain amino acid aminotransferase A6J74_07860 ENOG4105CHR reductase A6J74_07865 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A6J74_07895 ENOG4105H67 Protein of unknown function (DUF421) A6J74_07900 ENOG4105X5K response regulator receiver protein A6J74_07910 ENOG4105C8J )-transporter A6J74_07930 ENOG4105C6T cysteine synthase A6J74_07935 ENOG4105EU0 Major facilitator Superfamily A6J74_07940 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A6J74_07955 ENOG4105DXI Major Facilitator superfamily A6J74_07965 ENOG4105U3E Transcriptional regulator A6J74_07970 ENOG4105CSR polyphosphate kinase 2 A6J74_07990 ENOG4105E09 nadh pyrophosphatase A6J74_07995 ENOG4105FVX A6J74_08020 ENOG41067QW Transcriptional regulator A6J74_08040 ENOG4105C0D helicase A6J74_08065 ENOG4105C6K Malic enzyme A6J74_08070 ENOG4108IJ0 Aspartate ammonia-lyase A6J74_08080 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A6J74_08100 ENOG4105CJ1 ABC, transporter A6J74_08140 ENOG4106BRA Membrane A6J74_08160 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A6J74_08165 ENOG4107QIV Cytochrome c biogenesis protein A6J74_08185 ENOG4105EC3 peptidase S51, dipeptidase E A6J74_08190 ENOG4107QJQ Mate efflux family protein A6J74_08210 ENOG4105C9Q fumarate hydratase class II A6J74_08215 ENOG4105EMU Dehydrogenase A6J74_08220 ENOG4105VUF Transcriptional regulator A6J74_08225 ENOG4105DFD Na H antiporter A6J74_08235 ENOG4105CKI cobalamin synthesis protein A6J74_08245 ENOG4108UZ3 Transporter A6J74_08250 ENOG4105DRR Transcriptional regulator, GntR family A6J74_08260 ENOG4105PGM cation diffusion facilitator family transporter A6J74_08280 ENOG4105CAQ asparagine synthetase A6J74_08290 ENOG4105K56 Transcriptional regulator A6J74_08310 ENOG4105CVJ phosphoglycerate mutase A6J74_08345 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) A6J74_08350 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component A6J74_08355 ENOG4105C4Y ABC transporter A6J74_08360 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A6J74_08365 ENOG4105DUM transcriptional regulator, lysR family A6J74_08390 ENOG4105KAC Antibiotic biosynthesis monooxygenase A6J74_08430 ENOG4108KPB Flagellar basal-body rod protein FlgF A6J74_08435 ENOG4105FZW flagellar biosynthesis regulator FlhF A6J74_08440 ENOG4105D7B Flagellar biosynthesis protein flha A6J74_08445 ENOG4105D00 flagellar biosynthetic protein flhB A6J74_08455 ENOG4105VS8 Flagellar biosynthetic protein fliq A6J74_08460 ENOG4105CN7 Flagellar biosynthetic protein FliP A6J74_08470 ENOG4105DD5 Flagellar motor switch protein A6J74_08475 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A6J74_08485 ENOG4105E4C Lytic transglycosylase catalytic A6J74_08490 ENOG4105I03 Flagellin A6J74_08490 ENOG4105I03 Flagellin A6J74_08495 ENOG4105I03 Flagellin A6J74_08505 ENOG4107R88 Chemotaxis protein (CheV) A6J74_08520 ENOG4105BZE flagellar hook protein, FlgE A6J74_08550 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A6J74_08555 ENOG4107U2N Flagellar M-ring protein A6J74_08560 ENOG41075Z6 flagellar hook-basal body complex protein fliE A6J74_08565 ENOG4108ZC9 flagellar basal-body rod protein flgc A6J74_08570 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) A6J74_08590 ENOG4105DTJ flagellar hook-associated protein A6J74_08595 ENOG4105E1Q flagellar hook-associated protein A6J74_08615 ENOG4105BZU Histidine kinase A6J74_08630 ENOG4105DD5 Flagellar motor switch protein A6J74_08635 ENOG4105CBS Chea signal transduction histidine kinase A6J74_08640 ENOG4107YTP response regulator receiver protein A6J74_08645 ENOG4105ER2 Ompa motb domain protein A6J74_08650 ENOG4107R0U MotA TolQ exbB proton channel A6J74_08660 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) A6J74_08710 ENOG41080C8 DUF218 domain A6J74_08715 ENOG4105H67 Protein of unknown function (DUF421) A6J74_08725 ENOG4108Z5V transcriptional regulator, merr family A6J74_08730 ENOG4107RWR Sodium hydrogen exchanger A6J74_08740 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A6J74_08805 ENOG41081VK Ribonuclease A6J74_08825 ENOG4108SZE gCN5-related N-acetyltransferase A6J74_08855 ENOG4106032 Glutathionylspermidine synthase A6J74_08870 ENOG4105D7V transposase A6J74_08890 ENOG4105KHC sulfurtransferase A6J74_08900 ENOG4108W0I acetyltransferase A6J74_08910 ENOG410890F Dynamin family A6J74_08920 ENOG4105DHF Membrane A6J74_08925 ENOG4105C2W permease A6J74_08930 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) A6J74_08935 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A6J74_08950 ENOG4105CTD carboxy-peptidase A6J74_08955 ENOG4105DVT helicase A6J74_08965 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) A6J74_08975 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) A6J74_09025 ENOG4105BZ4 penicillin-binding protein A6J74_09035 ENOG4105CSM endonuclease III A6J74_09055 ENOG4105YAC A6J74_09060 ENOG4105DVT helicase A6J74_09100 ENOG4105CPK Glycosyl transferase (Group 1 A6J74_09105 ENOG4105FJR Lmbe family A6J74_09120 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase A6J74_09125 ENOG4108JYZ YitT family A6J74_09165 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A6J74_09170 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) A6J74_09185 ENOG41068YB TPR repeat-containing protein A6J74_09205 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A6J74_09210 ENOG4105EAH synthase A6J74_09220 ENOG4105XXQ heptaprenyl diphosphate synthase component I A6J74_09235 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) A6J74_09265 ENOG41065D1 A6J74_09270 ENOG4105S2F A6J74_09285 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) A6J74_09305 ENOG4105HDK L-asparaginase A6J74_09310 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase A6J74_09335 ENOG4108S6Z Negative regulator of genetic competence A6J74_09340 ENOG4108XDN Transcriptional regulator A6J74_09345 ENOG4107RGJ metallophosphoesterase A6J74_09355 ENOG4105I7S Abortive infection protein A6J74_09360 ENOG4105C9U ATP-dependent DNA helicase RecQ A6J74_09365 ENOG4105T7X A6J74_09375 ENOG4108SAX Membrane A6J74_09385 ENOG41063SB peptidase A6J74_09390 ENOG4108WBT adenosyltransferase A6J74_09395 ENOG4105BZU Histidine kinase A6J74_09400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_09405 ENOG4105CRE cytochrome C A6J74_09410 ENOG4107TWT Cytochrome c biogenesis protein A6J74_09420 ENOG4105FE9 pseudouridine synthase A6J74_09430 ENOG4108JIC nucleoside recognition domain protein A6J74_09435 ENOG4105DZ1 carboxypeptidase A6J74_09440 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A6J74_09470 ENOG4105BZU Histidine kinase A6J74_09485 ENOG4105I3N Conserved Protein A6J74_09490 ENOG4105BZU Histidine kinase A6J74_09505 ENOG4105BZ4 penicillin-binding protein A6J74_09510 ENOG4107GRR phosphate transport regulator A6J74_09515 ENOG4105CJ3 phosphate transporter A6J74_09560 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A6J74_09580 ENOG4105WH1 Two component transcriptional regulator luxr family A6J74_09585 ENOG4105ENE Histidine kinase A6J74_09605 ENOG4105DFD Na H antiporter A6J74_09625 ENOG4105C8J )-transporter A6J74_09635 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein A6J74_09640 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A6J74_09645 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A6J74_09655 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A6J74_09660 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) A6J74_09665 ENOG4107S4M Sulfate adenylate transferase A6J74_09680 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A6J74_09690 ENOG4105E0M Sulfatase A6J74_09695 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A6J74_09700 ENOG4105C5I Dehydrogenase A6J74_09710 ENOG4107RVV histidinol phosphate phosphatase, hisj family A6J74_09715 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase A6J74_09735 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) A6J74_09765 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A6J74_09785 ENOG4108ZP8 Acetolactate synthase small subunit A6J74_09790 ENOG4105C7K acetolactate synthase A6J74_09795 ENOG4105CM2 brancheD-chain amino acid aminotransferase A6J74_09825 ENOG4105KBJ sporulation protein ytfj A6J74_09830 ENOG41063Y9 A6J74_09835 ENOG4105CZN Potassium uptake protein A6J74_09870 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A6J74_09875 ENOG4107QMU Mate efflux family protein A6J74_09915 ENOG4105NQC Flavodoxin A6J74_09940 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A6J74_09950 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A6J74_09955 ENOG4105EA8 2-Nitropropane dioxygenase A6J74_09960 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A6J74_10000 ENOG4105CJ1 ABC, transporter A6J74_10010 ENOG4105CZV ABC transporter A6J74_10015 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A6J74_10020 ENOG4105C8Y Acetylornithine aminotransferase A6J74_10025 ENOG4105C26 Dehydrogenase A6J74_10030 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A6J74_10045 ENOG4105D82 Glutamate dehydrogenase A6J74_10050 ENOG4105CUB amino acid A6J74_10055 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A6J74_10070 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) A6J74_10090 ENOG4108R6G acetyltransferase A6J74_10115 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) A6J74_10120 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase A6J74_10125 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) A6J74_10130 ENOG4105BZU Histidine kinase A6J74_10140 ENOG4106DF1 A6J74_10150 ENOG41090MY MarR family Transcriptional regulator A6J74_10155 ENOG4105BZU Histidine kinase A6J74_10170 ENOG4105PXI polysaccharide deacetylase A6J74_10180 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) A6J74_10200 ENOG4105E98 transcriptional regulator DeoR family A6J74_10220 ENOG4107RCV ABC transporter, permease A6J74_10225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) A6J74_10230 ENOG4105C4Y ABC transporter A6J74_10265 ENOG4105CHR reductase A6J74_10285 ENOG4108Z7G MaoC domain protein dehydratase A6J74_10290 ENOG410681C small acid-soluble spore protein A6J74_10295 ENOG4105CZN Potassium uptake protein A6J74_10300 ENOG4107TS3 membrane protein, TerC A6J74_10305 ENOG4108QTI )-transporter A6J74_10315 ENOG4106A3R peptidase A6J74_10335 ENOG4105JXH GntR family transcriptional regulator A6J74_10340 ENOG4105BZU Histidine kinase A6J74_10345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_10360 ENOG4105CQB FAD linked oxidase domain protein A6J74_10365 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A6J74_10370 ENOG4105K4I Scp-like extracellular A6J74_10380 ENOG4108YBP pseudouridine synthase A6J74_10390 ENOG4105EYF MMPL domain protein A6J74_10400 ENOG4107RUE extracellular solute-binding protein family 1 A6J74_10405 ENOG4105D38 putrescine abc transporter A6J74_10410 ENOG4105F38 ABC transporter, permease A6J74_10420 ENOG4105C26 Dehydrogenase A6J74_10455 ENOG4105VFR signal peptidase A6J74_10460 ENOG4105DZ1 carboxypeptidase A6J74_10505 ENOG4105RHA ABC transporter, permease A6J74_10510 ENOG4108IUX (ABC) transporter A6J74_10550 ENOG4105VZ8 Transcriptional regulator A6J74_10555 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 A6J74_10560 ENOG4105C7S Dehydrogenase A6J74_10580 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A6J74_10675 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A6J74_10690 ENOG4108I0Q anthranilate phosphoribosyltransferase A6J74_10695 ENOG4105DDQ anthranilate synthase A6J74_10700 ENOG4105CRQ synthase (Component I) A6J74_10710 ENOG4105CK7 Sodium proline symporter A6J74_10725 ENOG4108RNG Permease of the drug metabolite transporter A6J74_10785 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A6J74_10795 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase A6J74_10800 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) A6J74_10820 ENOG4107TVC Glycosyl transferase, family 2 A6J74_10840 ENOG4105K64 Glycosyl transferase, family 2 A6J74_10870 ENOG4105EMS pseudouridine synthase A6J74_10875 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A6J74_10890 ENOG4105MIX Adenylate cyclase A6J74_10895 ENOG4108Z18 K06886 hemoglobin A6J74_10910 ENOG4105DPN Oligoendopeptidase f A6J74_10920 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A6J74_10930 ENOG4108ZCF integral membrane protein A6J74_10955 ENOG4105UQX Mate efflux family protein A6J74_10960 ENOG4108JQ7 (ABC) transporter A6J74_10970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A6J74_10975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A6J74_10995 ENOG4105C31 Tryptophanyl-tRNA synthetase A6J74_11015 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A6J74_11020 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A6J74_11045 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit A6J74_11060 ENOG4108KP7 hydrolase A6J74_11070 ENOG41073B9 A6J74_11075 ENOG4107AYK membrAne A6J74_11085 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A6J74_11100 ENOG4105QNR S1 RNA binding domain protein A6J74_11110 ENOG4107A6P A6J74_11125 ENOG4105BZU Histidine kinase A6J74_11130 ENOG4105CH6 catalase A6J74_11140 ENOG4105CAQ asparagine synthetase A6J74_11165 ENOG4105ERH Fumarylacetoacetate hydrolase A6J74_11210 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation A6J74_11235 ENOG4105XVF Competence transcription factor A6J74_11245 ENOG4105VEQ Cold shock protein A6J74_11270 ENOG4107QP3 malate synthase g A6J74_11280 ENOG4105C8Q Methyl-accepting chemotaxis A6J74_11285 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 A6J74_11320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A6J74_11340 ENOG41086D8 Transcriptional regulator A6J74_11345 ENOG4108AEY RNA polymerase sigma factor A6J74_11355 ENOG4107TVP HD domain protein A6J74_11365 ENOG4107RN3 metallophosphoesterase A6J74_11385 ENOG4105CEY Amp-dependent synthetase and ligase A6J74_11395 ENOG4105DF9 Lipoate-protein, ligase A6J74_11400 ENOG4108RQ5 Beta-lactamase domain-containing protein A6J74_11405 ENOG4106AXD A6J74_11450 ENOG4105ECB domain protein A6J74_11485 ENOG4105C1Q protoporphyrinogen oxidase A6J74_11490 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A6J74_11500 ENOG4105BZ4 penicillin-binding protein A6J74_11505 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation A6J74_11510 ENOG4105CKV Membrane A6J74_11515 ENOG410905X membrane-flanked domain protein A6J74_11560 ENOG4105CKV Membrane A6J74_11565 ENOG410905X membrane-flanked domain protein A6J74_11605 ENOG4105K59 histidine triad (HIT) protein A6J74_11635 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A6J74_11640 ENOG4105EEM helicase A6J74_11655 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A6J74_11670 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A6J74_11675 ENOG41067QW Transcriptional regulator A6J74_11715 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A6J74_11735 ENOG4106D4I domain protein A6J74_11740 ENOG4107VRP DNA repair exonuclease A6J74_11775 ENOG4105C6F GntR Family Transcriptional Regulator A6J74_11780 ENOG4105DJ2 Major Facilitator Superfamily A6J74_11810 ENOG4105BZU Histidine kinase A6J74_11815 ENOG4105BZU Histidine kinase A6J74_11820 ENOG4108MJI response regulator A6J74_11830 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6J74_11840 ENOG4105WN5 stage II sporulation protein A6J74_11895 ENOG41062D9 Histidine kinase A6J74_11900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_11915 ENOG410847I Transcriptional regulator, BadM Rrf2 family A6J74_11925 ENOG4105CMT Dihydroxyacetone kinase A6J74_11935 ENOG4105CMT Dihydroxyacetone kinase A6J74_11950 ENOG4105WAB arsR family transcriptional regulator A6J74_11955 ENOG4105F27 Major Facilitator A6J74_11985 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A6J74_11995 ENOG4105CS2 ec 3.2.1.21 A6J74_12000 ENOG4105C5Y PTS System A6J74_12005 ENOG4105CID antiterminator A6J74_12015 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A6J74_12055 ENOG4105C0R drug resistance transporter emrb qaca subfamily A6J74_12075 ENOG4105C26 Dehydrogenase A6J74_12080 ENOG4105CDU Replicative dna helicase A6J74_12145 ENOG4108MRH transcriptional regulatory protein A6J74_12155 ENOG4105CSH Transporter A6J74_12280 ENOG410780I phosphoprotein phosphatase activity A6J74_12310 ENOG4108JQ7 (ABC) transporter A6J74_12320 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A6J74_12350 ENOG4105D5U fad dependent oxidoreductase A6J74_12355 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) A6J74_12380 ENOG4105DER m42 family A6J74_12405 ENOG4105CGU Enoyl-CoA hydratase A6J74_12415 ENOG4105CHH sulfate transporter A6J74_12430 ENOG4105D4P Coproporphyrinogen iii oxidase A6J74_12450 ENOG4107FQX Alpha-acetolactate decarboxylase A6J74_12475 ENOG410839P A6J74_12490 ENOG4105CDA abc transporter atp-binding protein A6J74_12495 ENOG4105DRP amino acid AbC transporter A6J74_12510 ENOG4105BZ1 (ABC) transporter A6J74_12515 ENOG4105BZ1 (ABC) transporter A6J74_12530 ENOG4105C26 Dehydrogenase A6J74_12535 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A6J74_12540 ENOG4105D5Q Arginine ornithine antiporter A6J74_12550 ENOG4107RKG DJ-1/PfpI family A6J74_12560 ENOG4105E5W Transporter A6J74_12565 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) A6J74_12575 ENOG4105NF4 modulator of drug activity A6J74_12600 ENOG4105KPY Small multidrug resistance protein A6J74_12605 ENOG4105KPY Small multidrug resistance protein A6J74_12635 ENOG4108YXU transcriptional regulator AsnC family A6J74_12675 ENOG4106KNT transcriptional regulator A6J74_12685 ENOG4107RWR Sodium hydrogen exchanger A6J74_12690 ENOG4105CUB amino acid A6J74_12725 ENOG4107T5V SNARE associated Golgi A6J74_12760 ENOG4105WEF catalase A6J74_12790 ENOG4105C19 ABC transporter A6J74_12795 ENOG4107RBB ABC transporter, permease A6J74_12800 ENOG41069ER domain protein A6J74_12820 ENOG4105VZJ PTS System A6J74_12825 ENOG4105VCP PTS System A6J74_12830 ENOG4105EMD TRANSCRIPTIONal A6J74_12845 ENOG4105CZM Major Facilitator A6J74_12860 ENOG4108KGH TRANSCRIPTIONal A6J74_12870 ENOG41087NI Sulfite exporter TauE/SafE A6J74_12875 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase A6J74_12880 ENOG41085GJ domain protein A6J74_12885 ENOG4105VFE sira family A6J74_12890 ENOG4105VFE sira family A6J74_12895 ENOG4107TPS domain protein A6J74_12900 ENOG4105VFE sira family A6J74_12905 ENOG4105XTG Pfam:DUF156 A6J74_12910 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase A6J74_12925 ENOG4105ED1 spovr family A6J74_12930 ENOG4107Y03 Nitroreductase A6J74_12950 ENOG4108B31 Spore germination protein A6J74_12970 ENOG4105K63 Thioredoxin A6J74_12985 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein A6J74_12995 ENOG4105C7N Xanthine uracil vitamin C permease A6J74_13010 ENOG4105CNN ABC, transporter A6J74_13025 ENOG4108INS Transcriptional regulator A6J74_13040 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) A6J74_13045 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A6J74_13050 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) A6J74_13080 ENOG4105DWF phosphomethylpyrimidine kinase A6J74_13085 ENOG4105D06 uba thif-type nad fad binding protein A6J74_13100 ENOG41080HI glycine oxidase A6J74_13105 ENOG4108VEU Thiamine monophosphate synthase A6J74_13115 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A6J74_13125 ENOG4105ETU transcriptional activator (TenA A6J74_13150 ENOG41080XQ Signal transduction protein with cbs domains A6J74_13280 ENOG4105E2Z phosphate ABC transporter (Permease A6J74_13285 ENOG4105C8U phosphate abc transporter A6J74_13290 ENOG4105CVA phosphate A6J74_13295 ENOG4105CE1 Ferrous iron transport protein b A6J74_13300 ENOG4105CE1 Ferrous iron transport protein b A6J74_13305 ENOG4105CE1 Ferrous iron transport protein b A6J74_13315 ENOG4108NHD germination protein A6J74_13330 ENOG4105E1V na solute symporter A6J74_13335 ENOG4106CAD Protein of unknown function (DUF3311) A6J74_13355 ENOG4105E2S oxidase) subunit II A6J74_13360 ENOG4105BZ9 Cytochrome C oxidase, subunit I A6J74_13365 ENOG4105CCU oxidase (Subunit III) A6J74_13400 ENOG4105C7N Xanthine uracil vitamin C permease A6J74_13405 ENOG4105C85 amino acid A6J74_13425 ENOG4105DUX Transporter A6J74_13440 ENOG4107D63 A6J74_13445 ENOG4105VZ8 Transcriptional regulator A6J74_13450 ENOG41069ER domain protein A6J74_13455 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A6J74_13490 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) A6J74_13530 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) A6J74_13535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A6J74_13540 ENOG4105CNN ABC, transporter A6J74_13545 ENOG4105C2J ABC transporter A6J74_13555 ENOG4108RVA ribokinase A6J74_13560 ENOG4105ETE Transcriptional regulator (LacI family A6J74_13565 ENOG4105C0R drug resistance transporter emrb qaca subfamily A6J74_13570 ENOG41067TZ transcriptional regulator, MarR family A6J74_13575 ENOG4105CXY transporter A6J74_13585 ENOG41068KF Universal stress protein A6J74_13590 ENOG4105CHH sulfate transporter A6J74_13605 ENOG4105BZU Histidine kinase A6J74_13610 ENOG4105NAE bifunctional deaminase-reductase domain protein A6J74_13615 ENOG4105D29 Helix-turn-helix type 11 domain protein A6J74_13625 ENOG4105GFR rna polymerase sigma factor A6J74_13640 ENOG4108IQI permease A6J74_13645 ENOG4105DRP amino acid AbC transporter A6J74_13650 ENOG4105EAD ABC transporter A6J74_13655 ENOG4105CT1 (ABC) transporter A6J74_13660 ENOG4105CDA abc transporter atp-binding protein A6J74_13670 ENOG4105BZG amino acid carrier protein A6J74_13675 ENOG4105CRN Aminoglycoside phosphotransferase A6J74_13685 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin A6J74_13690 ENOG4105WH1 Two component transcriptional regulator luxr family A6J74_13695 ENOG4105BZU Histidine kinase A6J74_13700 ENOG4105E1K spore germination protein A6J74_13715 ENOG4105CG3 alpha amylase, catalytic region A6J74_13720 ENOG4105C5Y PTS System A6J74_13725 ENOG4107414 GntR family transcriptional regulator A6J74_13730 ENOG4105D5Q Arginine ornithine antiporter A6J74_13735 ENOG4105BZU Histidine kinase A6J74_13745 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A6J74_13750 ENOG4105GMT ATPase associated with various cellular activities aaa_5 A6J74_13755 ENOG4107T89 von Willebrand factor, type A A6J74_13765 ENOG4105EXW epimerase dehydratase A6J74_13770 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A6J74_13775 ENOG4105DMQ Methyltransferase A6J74_13780 ENOG4105E0A ABC, transporter A6J74_13785 ENOG4108IHU transport system permease protein A6J74_13790 ENOG4105DQ5 transport system permease protein A6J74_13795 ENOG4108MES Periplasmic binding protein A6J74_13800 ENOG4105DUX Transporter A6J74_13815 ENOG4105DAA L-lactate A6J74_13820 ENOG4108IJ0 Aspartate ammonia-lyase A6J74_13825 ENOG4105C37 (CBS) domain A6J74_13830 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase A6J74_13835 ENOG4105D9N nucleoside A6J74_13845 ENOG4108KGH TRANSCRIPTIONal A6J74_13850 ENOG41073R8 VanW family A6J74_13880 ENOG4105DAP Nicotinate phosphoribosyltransferase A6J74_13885 ENOG4105C59 p-type ATPase A6J74_13900 ENOG4105CUB amino acid A6J74_13920 ENOG4108JB9 formate dehydrogenase A6J74_13925 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A6J74_13930 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A6J74_13940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_13945 ENOG4105BZU Histidine kinase A6J74_13955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A6J74_13960 ENOG4108UZ3 Transporter A6J74_13970 ENOG4105C6K Malic enzyme A6J74_13980 ENOG4108MRH transcriptional regulatory protein A6J74_14005 ENOG4105US7 Histidine kinase A6J74_14010 ENOG4108STX response regulator A6J74_14015 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) A6J74_14020 ENOG4105BZ7 extracellular solute-binding protein family 1 A6J74_14025 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component A6J74_14030 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component A6J74_14035 ENOG4108IJ9 (ABC) transporter A6J74_14040 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A6J74_14065 ENOG4105D4T Citrate transporter A6J74_14070 ENOG4108V9W transcriptional regulatory protein A6J74_14075 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism A6J74_14085 ENOG4105DZ6 Band 7 protein A6J74_14105 ENOG4106AKX UPF0229 protein A6J74_14115 ENOG4105CYN Serine protein kinase A6J74_14130 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A6J74_14140 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A6J74_14150 ENOG4108R9S DSBA oxidoreductase A6J74_14155 ENOG4108JQC penicillin-binding protein 1A A6J74_14280 ENOG4105G5W regulator Fur family A6J74_14285 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A6J74_14305 ENOG4108IUW ABC transporter A6J74_14315 ENOG4105CBC glutamate synthase A6J74_14320 ENOG4107NBY Membrane A6J74_14325 ENOG4105BZ1 (ABC) transporter A6J74_14345 ENOG4106BXE A6J74_14350 ENOG4105CEN a g-specific adenine glycosylase A6J74_14355 ENOG41067AE Membrane-bound metal-dependent hydrolase A6J74_14385 ENOG4105ECP epimerase A6J74_14390 ENOG4105CI2 imidazolone-5-propionate hydrolase A6J74_14410 ENOG4105F1A Pyruvate formate-lyase A6J74_14415 ENOG4105C6N Formate acetyltransferase A6J74_14425 ENOG4105CKK Glycosyl transferase, family 2 A6J74_14430 ENOG4105C3I Nad-dependent epimerase dehydratase A6J74_14435 ENOG4107QQG Dehydrogenase A6J74_14440 ENOG4105CKK Glycosyl transferase, family 2 A6J74_14460 ENOG4108A04 Beta-lactamase A6J74_14475 ENOG4105CSV Glutaminase A6J74_14505 ENOG4108IQI permease A6J74_14515 ENOG4108JUB Transcriptional regulator A6J74_14525 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A6J74_14565 ENOG4105UPD Calcium Proton A6J74_14570 ENOG410606W general stress protein A6J74_14585 ENOG4107ZTW SNARE associated Golgi A6J74_14605 ENOG4108IPJ Membrane A6J74_14610 ENOG4105C59 p-type ATPase A6J74_14620 ENOG4107U9T Pfam:Ribonuclease_BN A6J74_14630 ENOG4105KJF protein tyrosine phosphatase A6J74_14650 ENOG4108TTB tellurium resistance protein A6J74_14655 ENOG4107TS3 membrane protein, TerC A6J74_14660 ENOG4106FN3 tellurium resistance protein A6J74_14665 ENOG4106FN3 tellurium resistance protein A6J74_14670 ENOG4108N0M stress protein A6J74_14705 ENOG4105DEU major facilitator superfamily A6J74_14725 ENOG41062JF Transcriptional regulator A6J74_14765 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component A6J74_14785 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter A6J74_14790 ENOG4105C7B Threonine dehydratase A6J74_14805 ENOG4105C9U ATP-dependent DNA helicase RecQ A6J74_14820 ENOG4105CI1 PTS System A6J74_14830 ENOG4105DNP FAD linked oxidase domain protein A6J74_14845 ENOG4105C5B carbamate kinase A6J74_14855 ENOG4105DBV ornithine carbamoyltransferase A6J74_14870 ENOG4105C8Q Methyl-accepting chemotaxis A6J74_14880 ENOG4105EAB amino acid AbC transporter A6J74_14885 ENOG4105E5Q amino acid AbC transporter A6J74_14900 ENOG4105D2S major facilitator superfamily A6J74_14905 ENOG410756H nucleotidyltransferase A6J74_14925 ENOG4105BZU Histidine kinase A6J74_14940 ENOG4106UIA A6J74_14945 ENOG4106UIA A6J74_14965 ENOG4105CAY ferredoxin--nadp reductase A6J74_14975 ENOG4108V5C ABC transporter A6J74_14980 ENOG4105DQ5 transport system permease protein A6J74_14985 ENOG4105EHG Permease protein A6J74_14990 ENOG4107W7X Aldolase A6J74_15000 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) A6J74_15005 ENOG4105D3R alkyl hydroperoxide reductase A6J74_15025 ENOG4105DFD Na H antiporter A6J74_15035 ENOG4105DTQ mandelate racemase muconate lactonizing A6J74_15050 ENOG4108W15 Protein of unknown function (DUF1456) A6J74_15060 ENOG4105BZU Histidine kinase A6J74_15070 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A6J74_15075 ENOG4105D9N nucleoside A6J74_15100 ENOG4105KPY Small multidrug resistance protein A6J74_15105 ENOG4105C26 Dehydrogenase A6J74_15115 ENOG4108JPW Aminotransferase A6J74_15120 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A6J74_15125 ENOG4105CBD Diacylglycerol kinase A6J74_15145 ENOG4107I77 yiaA/B two helix domain A6J74_15150 ENOG410834F Transcriptional regulator A6J74_15170 ENOG4105D01 (LipO)protein A6J74_15175 ENOG4108UMI ABC transporter, permease A6J74_15185 ENOG4108W2Y isochorismatase A6J74_15210 ENOG4105C4R Atp-dependent dna helicase A6J74_15235 ENOG4105C12 Phosphoribosylglycinamide synthetase A6J74_15240 ENOG4105DC1 bifunctional purine biosynthesis protein purh A6J74_15245 ENOG4108V3E phosphoribosylglycinamide formyltransferase A6J74_15270 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A6J74_15280 ENOG4105C83 adenylosuccinate lyase A6J74_15285 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A6J74_15290 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A6J74_15315 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A6J74_15370 ENOG4105SX7 Transporter A6J74_15440 ENOG4107ZXU DSBA oxidoreductase A6J74_15465 ENOG4105BZU Histidine kinase A6J74_15475 ENOG4105C7N Xanthine uracil vitamin C permease A6J74_15490 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A6J74_15500 ENOG4108TYN CAAX amino terminal protease family protein A6J74_15515 ENOG4105C5H ABC transporter A6J74_15520 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A6J74_15525 ENOG410801F ribosomal-protein-alanine acetyltransferase A6J74_15530 ENOG41072GX Peptidase M22 Glycoprotease A6J74_15535 ENOG4105K8N protein family UPF0079, ATPase A6J74_15640 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) A6J74_15650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A6J74_15655 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein A6J74_15680 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A6J74_15685 ENOG4105CPF Cell wall formation (By similarity) A6J74_15690 ENOG4108SC4 )-transporter A6J74_15695 ENOG4105CUB amino acid A6J74_15705 ENOG4105ERH Fumarylacetoacetate hydrolase A6J74_15710 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase A6J74_15740 ENOG410667J hydrolase A6J74_15745 ENOG4108JQ7 (ABC) transporter A6J74_15750 ENOG4105C3U ABC transporter A6J74_15755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A6J74_15765 ENOG4105DEF Extracellular solute-binding protein, family 5 A6J74_15775 ENOG4105C5H ABC transporter A6J74_15800 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) A6J74_15820 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A6J74_15845 ENOG4105F6E Acyl-transferase A6J74_15885 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family A6J74_15890 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A6J74_15895 ENOG4105E0C molybdate abc transporter A6J74_15905 ENOG4106Z1T Nicotinamide Mononucleotide Transporter A6J74_15925 ENOG4108J59 Extracellular solute-binding protein, family 5 A6J74_15930 ENOG4108J59 Extracellular solute-binding protein, family 5 A6J74_15960 ENOG4108JQ7 (ABC) transporter A6J74_15965 ENOG4105C3U ABC transporter A6J74_15970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A6J74_15975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A6J74_15990 ENOG4105C2C drug resistance transporter, Bcr CflA A6J74_16005 ENOG4105IQ5 FAD linked oxidase domain protein A6J74_16015 ENOG4105EE1 crotonyl-CoA reductase A6J74_16020 ENOG4105D01 (LipO)protein A6J74_16030 ENOG4108UMI ABC transporter, permease A6J74_16035 ENOG4108PSK reductase A6J74_16055 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) A6J74_16070 ENOG4107U5W ybbr family A6J74_16075 ENOG4105C8B TIGR00159 family A6J74_16160 ENOG4108NMV polysaccharide deacetylase A6J74_16175 ENOG4105D1F ATP-binding protein A6J74_16200 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A6J74_16205 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) A6J74_16210 ENOG4108JJB ABC transporter A6J74_16240 ENOG41067V7 50S ribosomal protein L36 A6J74_16250 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A6J74_16260 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A6J74_16270 ENOG4105VPB 50S ribosomal protein L30 A6J74_16285 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A6J74_16390 ENOG4105XPM ribosomal protein A6J74_16405 ENOG4107Y49 methyltransferase A6J74_16410 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A6J74_16420 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) A6J74_16430 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A6J74_16445 ENOG4105QIV RNA polymerase A6J74_16450 ENOG4105M0M Tetracycline resistance protein A6J74_16455 ENOG4105C2N RNA methyltransferase TrmH family group 3 A6J74_16470 ENOG4105D7W serine acetyltransferase A6J74_16490 ENOG4105CTP PilT protein domain protein A6J74_16500 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) A6J74_16515 ENOG4108Z0C Uvrb UvrC protein A6J74_16610 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A6J74_16620 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase A6J74_16625 ENOG4105KRF dihydroneopterin aldolase A6J74_16630 ENOG4105EEI dihydropteroate synthase A6J74_16635 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 A6J74_16640 ENOG4105DDQ anthranilate synthase A6J74_16645 ENOG4105CRQ synthase (Component I) A6J74_16650 ENOG4105C6T cysteine synthase A6J74_16665 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A6J74_16670 ENOG4108UGV hypoxanthine phosphoribosyltransferase A6J74_16695 ENOG41060GV RNA binding s1 domain protein A6J74_16710 ENOG4105VYY sporulation protein yabp A6J74_16715 ENOG41082I2 s4 domain protein A6J74_16720 ENOG4108IY2 MazG family A6J74_16730 ENOG4108M14 stage v sporulation protein t A6J74_16735 ENOG4108JA2 transcriptioN-repair coupling factor A6J74_16745 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) A6J74_16750 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A6J74_16765 ENOG4105KME endoribonuclease L-psp A6J74_16775 ENOG4105DFT pur operon repressor A6J74_16790 ENOG4105W42 Veg protein A6J74_16795 ENOG4105XFA sporulation peptidase YabG A6J74_16800 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A6J74_16805 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) A6J74_16810 ENOG4105F8V Hydrolase, tatD family A6J74_16815 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A6J74_16820 ENOG4105KRN Transcriptional regulator, abrb family A6J74_16825 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A6J74_16835 ENOG41060K3 Methyltransferase A6J74_16845 ENOG4105MA4 psp1 domain protein A6J74_16850 ENOG4105FA2 dna polymerase iii A6J74_16860 ENOG4105CXN decarboxylase A6J74_16895 ENOG41067KS pro-sigma K processing A6J74_16915 ENOG4105C6E dna polymerase iii A6J74_16925 ENOG4108Z6B deaminase A6J74_16935 ENOG4105GTG Isochorismatase A6J74_16945 ENOG4105ZMH deoxynucleoside kinase A6J74_16980 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A6J74_17015 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A6J74_17030 ENOG410848D S4 domain protein YaaA A6J74_17035 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A6J74_17055 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A6J74_17085 ENOG4107QJE Chromosome Partitioning Protein A6J74_17090 ENOG4105FA0 parb-like partition protein A6J74_17095 ENOG4108ZDA Sporulation protein YyaC A6J74_17100 ENOG4105D8X mechanosensitive ion channel A6J74_17105 ENOG4105VDK protein, conserved in bacteria A6J74_17110 ENOG4105C3G gtp-binding protein A6J74_17120 ENOG4108UUM single-stranded DNA-binding protein A6J74_17130 ENOG4108XMW Membrane A6J74_17135 ENOG4105BZR domain protein A6J74_17145 ENOG4105CDU Replicative dna helicase A6J74_17150 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A6J74_17175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_17180 ENOG4105BZU Histidine kinase A6J74_17195 ENOG4105Q2H domain protein A6J74_17200 ENOG4105C0H protease A6J74_17220 ENOG4105DPN Oligoendopeptidase f A6J74_17225 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) A6J74_17235 ENOG4105C1J atp-dependent rna helicase A6J74_17245 ENOG4108UT2 hemolysin iii A6J74_17250 ENOG4105CMR udp-glucose 4-epimerase A6J74_17265 ENOG4105IW1 AmiS UreI transporter A6J74_17275 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A6J74_17295 ENOG4107RGD Major Facilitator superfamily A6J74_17300 ENOG4108HRK Histidine kinase A6J74_17305 ENOG4108NEV two component transcriptional regulator, LytTR family A6J74_17320 ENOG4106F5Q Membrane A6J74_17325 ENOG4105E0X reductase A6J74_17335 ENOG41067SE Tetr family transcriptional regulator A6J74_17340 ENOG4105CKK Glycosyl transferase, family 2 A6J74_17360 ENOG4105C5H ABC transporter A6J74_17365 ENOG4108IG5 Transcriptional regulator A6J74_17385 ENOG4108S4H thioesterase Superfamily protein A6J74_17395 ENOG4106YBV Methyl-accepting chemotaxis A6J74_17400 ENOG4105EN6 Membrane A6J74_17410 ENOG4105CG5 Glycosyl transferase (Group 1 A6J74_17425 ENOG41079KZ Major Facilitator Superfamily A6J74_17430 ENOG4105DY9 regulatoR A6J74_17435 ENOG4105D22 carbon starvation protein A6J74_17440 ENOG4105VCD cytoplasmic protein A6J74_17445 ENOG4105BZU Histidine kinase A6J74_17450 ENOG4105DWF phosphomethylpyrimidine kinase A6J74_17455 ENOG4105BZU Histidine kinase A6J74_17460 ENOG4105WH1 Two component transcriptional regulator luxr family A6J74_17470 ENOG4108Y4K DNA-binding transcriptional activator A6J74_17495 ENOG4105D6E homoserine dehydrogenase A6J74_17510 ENOG41090WU lipolytic protein G-D-S-L family A6J74_17515 ENOG4105CJ1 ABC, transporter A6J74_17520 ENOG4108TU7 Inherit from COG: (ABC) transporter A6J74_17530 ENOG4105VCH membrane A6J74_17535 ENOG410667J hydrolase A6J74_17545 ENOG4107SVH Potassium channel protein A6J74_17565 ENOG4108VKI Cell wall hydrolase A6J74_17580 ENOG4107UEZ chlorite dismutase A6J74_17585 ENOG4108IJ2 phosphate acetyltransferase A6J74_17590 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) A6J74_17595 ENOG4108VCI transcription factor, rsfa family A6J74_17605 ENOG4105DQ5 transport system permease protein A6J74_17610 ENOG4105EHG Permease protein A6J74_17615 ENOG4105E0A ABC, transporter A6J74_17620 ENOG4108MES Periplasmic binding protein A6J74_17625 ENOG4105DCI Phosphohydrolase A6J74_17630 ENOG41069HH 4-oxalocrotonate tautomerase A6J74_17635 ENOG4108Z4T Peptidase M50 A6J74_17640 ENOG4108XFG YwhD family A6J74_17645 ENOG4105BZ4 penicillin-binding protein A6J74_17650 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A6J74_17655 ENOG4107SWG transcriptional regulator MERR family A6J74_17660 ENOG4105DXB Major Facilitator superfamily A6J74_17665 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A6J74_17670 ENOG4105CYW agmatinase A6J74_17700 ENOG410684U Domain of unknown function (DUF1934) A6J74_17715 ENOG4105IIU Aminopeptidase A6J74_17720 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) A6J74_17725 ENOG4108M15 ABC transporter A6J74_17730 ENOG4105KCT ABC transporter A6J74_17735 ENOG4105BZU Histidine kinase A6J74_17745 ENOG4105D4Y metalloprotease A6J74_17760 ENOG4105BZU Histidine kinase A6J74_17775 ENOG4105DF6 Fe-S oxidoreductase A6J74_17785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A6J74_17790 ENOG4105C1G acyl-Coa dehydrogenase A6J74_17795 ENOG4105C1G acyl-Coa dehydrogenase A6J74_17830 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A6J74_17840 ENOG4105CBT Fructose-1,6-bisphosphatase A6J74_17845 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A6J74_17855 ENOG4107104 thymidine kinase A6J74_17865 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A6J74_17870 ENOG4108ZXQ stage ii sporulation protein r A6J74_17880 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A6J74_17895 ENOG4107XC4 flavin reductase domain protein, FMN-binding A6J74_17900 ENOG4108VGI doxx family A6J74_17915 ENOG4108YZG isomerase A6J74_17920 ENOG4108UIC UPF0340 protein A6J74_17945 ENOG41062M3 atp synthase A6J74_17950 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) A6J74_17970 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A6J74_18005 ENOG4105BZU Histidine kinase A6J74_18010 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A6J74_18020 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain A6J74_18025 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A6J74_18050 ENOG4105D65 subunit l A6J74_18055 ENOG4105C8S subunit m A6J74_18060 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) A6J74_18065 ENOG4106778 Protein of unknown function (DUF1146) A6J74_18085 ENOG4105DY9 regulatoR A6J74_18100 ENOG4105FRN stage II sporulation protein A6J74_18110 ENOG4105MT0 Sporulation transcriptional regulator spoiiid A6J74_18125 ENOG4108QV3 biosynthesis protein A6J74_18130 ENOG4105HTX biosynthesis protein A6J74_18135 ENOG4107YJ4 chain length determinant protein A6J74_18140 ENOG4108RB3 Capsular polysaccharide biosynthesis protein A6J74_18145 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A6J74_18150 ENOG4105D3Q Sugar transferase A6J74_18160 ENOG4108PTS heparinase ii A6J74_18205 ENOG4107EF8 Glycosyl transferase (Group 1 A6J74_18210 ENOG4105CPK Glycosyl transferase (Group 1 A6J74_18220 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) A6J74_18225 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase A6J74_18235 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A6J74_18240 ENOG4108KGH TRANSCRIPTIONal A6J74_18250 ENOG4105KPE licD family A6J74_18255 ENOG4108KN0 Choline kinase A6J74_18260 ENOG4106MCE EamA-like transporter family A6J74_18270 ENOG4105CMR udp-glucose 4-epimerase A6J74_18275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_18280 ENOG41062D9 Histidine kinase A6J74_18295 ENOG4105CXY transporter A6J74_18305 ENOG4105C19 ABC transporter A6J74_18310 ENOG4107RBB ABC transporter, permease A6J74_18350 ENOG4105C0D helicase A6J74_18355 ENOG4105KBK Zinc finger, swim domain protein A6J74_18365 ENOG41069ER domain protein A6J74_18375 ENOG4105C94 Transporter A6J74_18385 ENOG4107R8N Glycosyl transferase, family 2 A6J74_18410 ENOG4105E0M Sulfatase A6J74_18425 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) A6J74_18435 ENOG4105DAA L-lactate A6J74_18470 ENOG4107RSM transcriptional regulator A6J74_18475 ENOG4105ECB domain protein A6J74_18480 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_18500 ENOG4105VZJ PTS System A6J74_18510 ENOG4105VCP PTS System A6J74_18515 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A6J74_18520 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A6J74_18520 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A6J74_18530 ENOG4105CK1 PTS System A6J74_18535 ENOG4105VCP PTS System A6J74_18540 ENOG4105F8D glycoside hydrolase family 4 A6J74_18560 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family A6J74_18570 ENOG4105ESV Glycosyl transferase, family 4 A6J74_18575 ENOG4105C6Y Udp-glucose 6-dehydrogenase A6J74_18580 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase A6J74_18585 ENOG4108KGH TRANSCRIPTIONal A6J74_18590 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein A6J74_18605 ENOG4105KVH Transcriptional regulator A6J74_18620 ENOG41081UC Inherit from COG: Competence protein A6J74_18625 ENOG4105VEQ Cold shock protein A6J74_18630 ENOG4105MS2 ribosomal subunit Interface protein A6J74_18650 ENOG4105CAK Cell division ATP-binding protein ftsE A6J74_18655 ENOG4105CRP Part of the ABC transporter FtsEX involved in A6J74_18660 ENOG4105CN1 protease A6J74_18670 ENOG4105BZ1 (ABC) transporter A6J74_18685 ENOG4108WS4 fmn reductase A6J74_18695 ENOG4105DUM transcriptional regulator, lysR family A6J74_18715 ENOG4107TXC Transcriptional regulator A6J74_18725 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A6J74_18730 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A6J74_18740 ENOG41086DT Membrane protein of unknown function A6J74_18760 ENOG4108S4C acetyltransferase A6J74_18770 ENOG4105C3M thioredoxin reductase A6J74_18780 ENOG4108Z4K mutator MutT protein A6J74_18785 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A6J74_18790 ENOG4105CHW UPF0052 protein A6J74_18800 ENOG4105KRI phosphocarrier protein (HPr A6J74_18805 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A6J74_18810 ENOG4108QY0 Membrane A6J74_18825 ENOG4105CZ3 stage V sporulation protein ad A6J74_18830 ENOG41090VF Stage v sporulation protein ac A6J74_18860 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6J74_18910 ENOG41067MG lrgb family A6J74_18915 ENOG4105XZU Preprotein translocase, subunit SecG A6J74_18925 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A6J74_18960 ENOG4105CM4 permease protein A6J74_18965 ENOG4108IPW abc transporter atp-binding protein A6J74_18980 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) A6J74_18985 ENOG4108V2W Carbonate dehydratase A6J74_19005 ENOG4108W2Y isochorismatase A6J74_19020 ENOG4108VY7 phosphate-starvation-inducible protein PsiE A6J74_19025 ENOG4108MK9 spermidine N(1)-acetyltransferase A6J74_19030 ENOG4105C5H ABC transporter A6J74_19050 ENOG4105WMR Protein CrcB homolog A6J74_19055 ENOG4105WMR Protein CrcB homolog A6J74_19065 ENOG4105C8Q Methyl-accepting chemotaxis A6J74_19075 ENOG4105D4A Cell wall formation (By similarity) A6J74_19080 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A6J74_19095 ENOG4105KVH Transcriptional regulator A6J74_19100 ENOG4105F27 Major Facilitator A6J74_19105 ENOG4105CV8 reductase A6J74_19120 ENOG4108RYK Nad-dependent epimerase dehydratase A6J74_19135 ENOG4105D9N nucleoside A6J74_19140 ENOG4105D9N nucleoside A6J74_19145 ENOG4105DHF Membrane A6J74_19155 ENOG41090A1 ferritin A6J74_19165 ENOG4108URH decarboxylase A6J74_19190 ENOG4108RMU ferritin dps family protein A6J74_19205 ENOG4105NCW Trka-c domain protein A6J74_19210 ENOG4107S91 Sodium hydrogen exchanger A6J74_19215 ENOG4107T5V SNARE associated Golgi A6J74_19230 ENOG4105C2I pirin domain protein A6J74_19235 ENOG4105D4Y metalloprotease A6J74_19240 ENOG4105VG1 fes assembly suf system protein A6J74_19245 ENOG4105C8Q Methyl-accepting chemotaxis A6J74_19250 ENOG4105C8Q Methyl-accepting chemotaxis A6J74_19260 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A6J74_19270 ENOG4105BZU Histidine kinase A6J74_19275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_19280 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein A6J74_19290 ENOG4107ZTW SNARE associated Golgi A6J74_19330 ENOG4107AYK membrAne A6J74_19340 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins A6J74_19355 ENOG4107R7I amino acid A6J74_19360 ENOG4105F27 Major Facilitator A6J74_19375 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A6J74_19395 ENOG4105DZ1 carboxypeptidase A6J74_19415 ENOG4105CHU acetyl-coa acetyltransferase A6J74_19420 ENOG4105C1G acyl-Coa dehydrogenase A6J74_19425 ENOG4108W8B Beta-lactamase domain protein A6J74_19450 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A6J74_19470 ENOG41080E8 Transcriptional regulator, Spx MgsR family A6J74_19505 ENOG4108UMI ABC transporter, permease A6J74_19510 ENOG4105D01 (LipO)protein A6J74_19515 ENOG4105D01 (LipO)protein A6J74_19520 ENOG4105C3K feS assembly ATPase SufC A6J74_19525 ENOG4105JRK feS assembly protein SufD A6J74_19530 ENOG4105C9B Cysteine desulfurase A6J74_19535 ENOG4108UNV SUF system FeS assembly protein, NifU family A6J74_19540 ENOG4105DIW FeS assembly protein SUFB A6J74_19545 ENOG4107R8B 5'-nucleotidase A6J74_19550 ENOG4105KZD Domain of unknown function (DUF1805) A6J74_19555 ENOG4108YTE sporulation protein YunB A6J74_19560 ENOG4105FAA peptidase M23 A6J74_19585 ENOG41090T1 Membrane A6J74_19590 ENOG4107TXC Transcriptional regulator A6J74_19595 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) A6J74_19600 ENOG4105MMD transcriptional regulator A6J74_19625 ENOG4105CBT Fructose-1,6-bisphosphatase A6J74_19640 ENOG4105D4U had-superfamily hydrolase, subfamily iia A6J74_19650 ENOG4105DYS nad(p)h dehydrogenase (quinone) A6J74_19675 ENOG4108W5N phosphatidylglycerophosphatase a A6J74_19690 ENOG41083MR nifu domain-containing protein A6J74_19730 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA A6J74_19735 ENOG4105C4B ABC transporter, permease A6J74_19740 ENOG4108JJA ABC, transporter A6J74_19765 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A6J74_19790 ENOG4105EWC Purine nucleoside phosphorylase A6J74_19815 ENOG4105CEP NADH dehydrogenase A6J74_19830 ENOG41069ER domain protein A6J74_19850 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A6J74_19865 ENOG4105KA0 thioesterase Superfamily protein A6J74_19870 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) A6J74_19890 ENOG4107R3E Citrate transporter A6J74_19900 ENOG4105Y38 Kinase-associated protein B A6J74_19915 ENOG4105C87 Aminotransferase class I and II A6J74_19925 ENOG4108MUZ hydrolase A6J74_19930 ENOG4105C5I Dehydrogenase A6J74_19935 ENOG4108ZB6 transcriptional regulator AsnC family A6J74_19940 ENOG4105CHM Aminotransferase A6J74_19950 ENOG4105WG9 Conserved Protein A6J74_19970 ENOG4107PBV potassium channel A6J74_19975 ENOG4105KT7 mgtC SapB transporter A6J74_20015 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A6J74_20120 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A6J74_20145 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) A6J74_20185 ENOG4105VEQ Cold shock protein A6J74_20195 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A6J74_20200 ENOG4105E4F Isochorismate synthase A6J74_20210 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) A6J74_20215 ENOG4108IPT Naphthoate synthase A6J74_20225 ENOG4105DTQ mandelate racemase muconate lactonizing A6J74_20230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_20245 ENOG41069H0 dihydroorotase EC 3.5.2.3 A6J74_20265 ENOG4105FDP GntR family transcriptional regulator A6J74_20270 ENOG4105C6Z Gluconate A6J74_20310 ENOG4105EMN RNA polymerase sigma factor A6J74_20325 ENOG41082BM Transcriptional regulator, arsr family A6J74_20335 ENOG4105CJ1 ABC, transporter A6J74_20345 ENOG41086D8 Transcriptional regulator A6J74_20350 ENOG4105C19 ABC transporter A6J74_20360 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A6J74_20365 ENOG4107ZTW SNARE associated Golgi A6J74_20380 ENOG4105C19 ABC transporter A6J74_20410 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) A6J74_20415 ENOG4108UGV hypoxanthine phosphoribosyltransferase A6J74_20440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_20445 ENOG4105BZU Histidine kinase A6J74_20475 ENOG41087YS Phage shock protein A A6J74_20515 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A6J74_20520 ENOG4105C4M (Ubiquinol oxidase) subunit I A6J74_20525 ENOG4108V2W Carbonate dehydratase A6J74_20575 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A6J74_20590 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component A6J74_20600 ENOG4105D2X ABC transporter substrate-binding protein A6J74_20615 ENOG4107T7U Sulfatase A6J74_20620 ENOG4107S9D Alpha beta hydrolase A6J74_20630 ENOG4105BZU Histidine kinase A6J74_20635 ENOG4105BZU Histidine kinase A6J74_20695 ENOG4105EPU Molybdenum cofactor synthesis domain protein A6J74_20705 ENOG4105BZF Glycosyl transferase (Group 1 A6J74_20710 ENOG4105YVM Phosphoesterase, PA-phosphatase related A6J74_20715 ENOG4108Z0R Transferase A6J74_20720 ENOG4105E8V Alpha Beta Hydrolase Fold protein A6J74_20745 ENOG4105N5T Radical SAM Protein A6J74_20765 ENOG4105C19 ABC transporter A6J74_20785 ENOG4105NCW Trka-c domain protein A6J74_20790 ENOG4107S91 Sodium hydrogen exchanger A6J74_20795 ENOG410605W Major Facilitator A6J74_20830 ENOG4108B31 Spore germination protein A6J74_20840 ENOG4105DWV Homoserine O-trans-acetylase A6J74_20850 ENOG41085GJ domain protein A6J74_20870 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A6J74_20875 ENOG4105D06 uba thif-type nad fad binding protein A6J74_20885 ENOG4105CVM Molybdenum cofactor synthesis domain protein A6J74_20890 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein A6J74_20895 ENOG4108ZAF Molybdopterin A6J74_20915 ENOG4107EXU Short-chain dehydrogenase reductase Sdr A6J74_20920 ENOG4108VJ1 Transcriptional regulator (CarD family A6J74_20965 ENOG4105CBX hi0933 family A6J74_20980 ENOG4105YW5 deoR family transcriptional regulator A6J74_20985 ENOG4107QSE Dipeptidase A6J74_21000 ENOG4108IUM Glycogen debranching enzyme A6J74_21005 ENOG4108V15 phosphotransferase enzyme family A6J74_21020 ENOG4105C8F Beta-lactamase domain protein A6J74_21035 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A6J74_21050 ENOG4108VDD TRNA binding domain protein A6J74_21060 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A6J74_21085 ENOG4108IPJ Membrane A6J74_21110 ENOG4105C88 aminopeptidase A6J74_21140 ENOG4105ETE Transcriptional regulator (LacI family A6J74_21165 ENOG4105EP9 oxidoreductase A6J74_21170 ENOG4107SNB ankyrin repeat protein YahD A6J74_21175 ENOG4105BZU Histidine kinase A6J74_21180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A6J74_21195 ENOG4105DGU Histone deacetylase A6J74_21200 ENOG4105W87 Cbs domain A6J74_21205 ENOG4105F1V Acetoin utilization protein A6J74_21215 ENOG4108UW5 maltose o-acetyltransferase A6J74_21225 ENOG4105EMN RNA polymerase sigma factor A6J74_21235 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A6J74_21265 ENOG4105C28 cystathionine A6J74_21275 ENOG4105U5Y Transcriptional regulator A6J74_21285 ENOG4106KR7 LysR family Transcriptional regulator A6J74_21310 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A6J74_21320 ENOG4105EFZ amidohydrolase A6J74_21335 ENOG4105KBJ sporulation protein ytfj A6J74_21340 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) A6J74_21350 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A6J74_21370 ENOG4108JYZ YitT family A6J74_21415 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_21420 ENOG4107YZX Universal stress protein A6J74_21440 ENOG41082W1 Cupin 2, conserved barrel domain protein A6J74_21475 ENOG4105DC7 peptidase M24 A6J74_21505 ENOG4105SFS phosphoesterase RecJ domain protein A6J74_21515 ENOG4105VV2 A6J74_21520 ENOG4105C0B DNA polymerase III (alpha subunit) A6J74_21525 ENOG4105C6K Malic enzyme A6J74_21530 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A6J74_21550 ENOG4105CA9 Pyruvate kinase A6J74_21555 ENOG4105FS0 cytoplasmic membrane protein A6J74_21560 ENOG4108REF Sporulation integral membrane protein ytvi A6J74_21575 ENOG4105BZN citrate synthase A6J74_21580 ENOG4108HMX isocitrate dehydrogenase (NADP) A6J74_21605 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A6J74_21610 ENOG4105BZU Histidine kinase A6J74_21615 ENOG4105C2M dna polymerase I A6J74_21620 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A6J74_21630 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A6J74_21635 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A6J74_21645 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A6J74_21670 ENOG4108TDW sporulation protein YtxC A6J74_21675 ENOG4105C22 threonyL-tRNA synthetase A6J74_21680 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A6J74_21700 ENOG4105CN9 Peptidase m42 family protein A6J74_21705 ENOG4108JGH Tetr family transcriptional regulator A6J74_21710 ENOG4105CW7 secretion protein, HlyD family A6J74_21715 ENOG4105C0R drug resistance transporter emrb qaca subfamily A6J74_21745 ENOG4108RWN rrna methyltransferase A6J74_21755 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A6J74_21760 ENOG4105C5S asparaginyl-tRNA synthetase A6J74_21775 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A6J74_21780 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) A6J74_21790 ENOG4105DCG PHP domain protein A6J74_21805 ENOG4105FE9 pseudouridine synthase A6J74_21815 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) A6J74_21825 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) A6J74_21840 ENOG4105E0A ABC, transporter A6J74_21845 ENOG4105KFN sortase, SrtB family A6J74_21855 ENOG4105DR4 Methyltransferase A6J74_21870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A6J74_21925 ENOG4105S6R Iron-hydroxamate transporter permease subunit A6J74_21930 ENOG4105J76 Periplasmic binding protein A6J74_21940 ENOG4105CEY Amp-dependent synthetase and ligase A6J74_21945 ENOG4107Z3H Transcriptional regulator, TetR family A6J74_21950 ENOG41060WC Enoyl-CoA hydratase A6J74_21955 ENOG4105BZJ Electron transfer flavoprotein A6J74_21960 ENOG4105C10 Electron transfer flavoprotein A6J74_21965 ENOG4105K63 Thioredoxin A6J74_21970 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A6J74_21980 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit A6J74_21990 ENOG4105E33 succinate dehydrogenase A6J74_22000 ENOG4108VXD carboxy-peptidase A6J74_22005 ENOG4105E14 MotA TolQ exbB proton channel A6J74_22010 ENOG4105ER2 Ompa motb domain protein A6J74_22015 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family A6J74_22020 ENOG4108IUX (ABC) transporter A6J74_22025 ENOG4105RHA ABC transporter, permease A6J74_22030 ENOG4108Z40 Transcriptional regulator A6J74_22035 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) A6J74_22045 ENOG4108JCI Transcriptional regulator A6J74_22050 ENOG41067S9 phage shock protein C, PspC A6J74_22055 ENOG4105DZC cytosine deaminase A6J74_22065 ENOG4105PFC Transcriptional regulator A6J74_22080 ENOG4108XJQ germination protein A6J74_22095 ENOG4105M59 Phosphodiesterase, mj0936 family A6J74_22120 ENOG4108QCI YvbH-like oligomerisation region A6J74_22150 ENOG4108IUQ atp-dependent protease A6J74_22170 ENOG4105K56 Transcriptional regulator A6J74_22195 ENOG4105D52 delta-aminolevulinic acid dehydratase A6J74_22205 ENOG41068KH stage VI sporulation protein D A6J74_22220 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A6J74_22245 ENOG4105DFF Rod shape-determining protein mreb A6J74_22250 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) A6J74_22265 ENOG4107QMS site-determining protein A6J74_22280 ENOG4105C03 ribonuclease A6J74_22290 ENOG4105X36 (ribosomal) protein A6J74_22315 ENOG4105EWM Histidine kinase A6J74_22335 ENOG4105CQC Prephenate dehydratase A6J74_22340 ENOG4108RPX mosc domain containing protein A6J74_22355 ENOG4108IYU L-aspartate oxidase A6J74_22360 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase A6J74_22390 ENOG4108HUF Transporter A6J74_22395 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A6J74_22400 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) A6J74_22405 ENOG41061AI Protein of unknown function (DUF2905) A6J74_22415 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A6J74_22420 ENOG4105VIE preprotein translocase, subunit YajC A6J74_22430 ENOG4108QG2 Membrane A6J74_22435 ENOG4105CKP Polysaccharide Biosynthesis Protein A6J74_22445 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A6J74_22450 ENOG41076HS cation diffusion facilitator family transporter A6J74_22455 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A6J74_22465 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A6J74_22495 ENOG4105CUT histidyl-tRNA synthetase A6J74_22505 ENOG4105CUZ uba thif-type nad fad binding protein A6J74_22520 ENOG4108VCI transcription factor, rsfa family A6J74_22525 ENOG4105D1H recombination factor protein RarA A6J74_22535 ENOG4105C3J Cysteine desulfurase A6J74_22540 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A6J74_22550 ENOG4105C7H Helicase, RecD TraA family A6J74_22555 ENOG41060CR A6J74_22570 ENOG4105C02 permease A6J74_22600 ENOG4105HHA aminodeoxychorismate lyase A6J74_22605 ENOG4108VQJ O-methyltransferase A6J74_22610 ENOG4105XYU peptidase (U32 family) A6J74_22615 ENOG4105CFP Peptidase U32 A6J74_22630 ENOG4107XRG penicillin-binding protein A6J74_22660 ENOG4105C28 cystathionine A6J74_22665 ENOG4108EKI Dehydrogenase A6J74_22680 ENOG4108HUF Transporter A6J74_22685 ENOG4105S6R Iron-hydroxamate transporter permease subunit A6J74_22725 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_22735 ENOG4105MIR Phenylalanine 4-monooxygenase A6J74_22745 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin A6J74_22780 ENOG4108MUZ hydrolase A6J74_22790 ENOG4105G6Z alkaline phosphatase A6J74_22805 ENOG4108TVJ Nitroreductase A6J74_22825 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6J74_22840 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase A6J74_22845 ENOG4105CQW ribosome biogenesis GTPase YqeH A6J74_22855 ENOG410812S Rna-binding protein A6J74_22860 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) A6J74_22865 ENOG4108WF2 Metal Dependent Phosphohydrolase A6J74_22875 ENOG4105DXX methyltransferase A6J74_22885 ENOG4105KQC Competence protein A6J74_22890 ENOG4108UK2 deaminase A6J74_22895 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A6J74_22905 ENOG4105TQK DNA polymerase iii, delta' subunit A6J74_22930 ENOG4105KVH Transcriptional regulator A6J74_22935 ENOG4105CSA Coproporphyrinogen iii oxidase A6J74_22955 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A6J74_22965 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) A6J74_22970 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A6J74_22980 ENOG4105KTH gatB Yqey A6J74_22985 ENOG41068P3 sporulation protein YqfC A6J74_23000 ENOG4105C9A Phoh family A6J74_23005 ENOG4105CTJ Metal Dependent Phosphohydrolase A6J74_23010 ENOG4107YVF Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A6J74_23015 ENOG4107YR5 Diacylglycerol kinase A6J74_23020 ENOG4105KG3 cytidine deaminase A6J74_23025 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A6J74_23050 ENOG4107XJU UPF0178 protein A6J74_23055 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A6J74_23060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6J74_23075 ENOG4105EGD dinuclear metal center protein, YbgI family A6J74_23100 ENOG41069ZM Protein of unknown function (DUF2624) A6J74_23105 ENOG4108JYZ YitT family A6J74_23110 ENOG4105FDK ABC transporter A6J74_23120 ENOG4105N80 Ferric uptake regulator, Fur family A6J74_23145 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A6J74_23155 ENOG4107RF6 penicillin-binding protein A6J74_23160 ENOG4105PWN phosphate abc transporter A6J74_23165 ENOG4105C8U phosphate abc transporter A6J74_23170 ENOG4105E2Z phosphate ABC transporter (Permease A6J74_23175 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A6J74_23180 ENOG4108UTW Plays a role in the regulation of phosphate uptake A6J74_23195 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A6J74_23205 ENOG4105DKQ ROK family A6J74_23215 ENOG4105C5X domain protein A6J74_23240 ENOG4105C28 cystathionine A6J74_23245 ENOG4105C28 cystathionine A6J74_23255 ENOG4105C3R Methionine synthase A6J74_23295 ENOG4107R6U sodium dicarboxylate symporter A6J74_23385 ENOG4105C0D helicase A6J74_23390 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A6J74_23400 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A6J74_23415 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A6J74_23420 ENOG4105CJ1 ABC, transporter A6J74_23455 ENOG41080TC multidrug resistance protein A6J74_23480 ENOG4105WZW rhodanese family A6J74_23485 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) A6J74_23515 ENOG4107YBY Hydrolase A6J74_23525 ENOG4105CBJ Metal-dependent enzyme A6J74_23540 ENOG4105DC7 peptidase M24 A6J74_23565 ENOG4105CD2 stage iii sporulation protein aa A6J74_23570 ENOG4105KR5 Stage iii sporulation protein A6J74_23575 ENOG4108CQH stage III sporulation protein AC A6J74_23580 ENOG4105KQ4 Stage iii sporulation protein ad A6J74_23590 ENOG410644B Stage III sporulation protein af A6J74_23615 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A6J74_23620 ENOG4108ZSR alkaline shock protein A6J74_23625 ENOG4105M7K Involved in the transcription termination process (By similarity) A6J74_23630 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) A6J74_23645 ENOG4105CTB Polyprenyl synthetase A6J74_23655 ENOG4105DX0 Hemolysin A A6J74_23665 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A6J74_23670 ENOG4105S1Z Stage IV sporulation protein B A6J74_23680 ENOG4107QQR Sporulation A6J74_23700 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A6J74_23710 ENOG4108JUB Transcriptional regulator A6J74_23725 ENOG4107RDP Dehydrogenase A6J74_23745 ENOG4105CPP Dehydrogenase, E1 component A6J74_23750 ENOG4105C7S Dehydrogenase A6J74_23765 ENOG4108QY0 Membrane A6J74_23770 ENOG4105E09 nadh pyrophosphatase A6J74_23775 ENOG4105G7B Protein of unknown function (DUF2992) A6J74_23790 ENOG4108HW3 (ABC) transporter A6J74_23795 ENOG4105E5Q amino acid AbC transporter A6J74_23800 ENOG4105CDA abc transporter atp-binding protein A6J74_23805 ENOG4108QEG Membrane A6J74_23810 ENOG4108VZI ErfK ybiS ycfS ynhG family protein A6J74_23825 ENOG4105D9U N-acetyltransferase A6J74_23830 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A6J74_23840 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A6J74_23850 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic A6J74_23875 ENOG4105EJQ L-serine dehydratase A6J74_23880 ENOG4105II7 pyrroline-5-carboxylate reductase A6J74_23885 ENOG41069FQ Metallo-beta-lactamase superfamily A6J74_23890 ENOG4108IXY short-chain dehydrogenase reductase A6J74_23900 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase A6J74_23945 ENOG4105CGH 5'-nucleotidase A6J74_23950 ENOG4105DFD Na H antiporter A6J74_23965 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A6J74_23980 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A6J74_23985 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) A6J74_24010 ENOG4108R6K riboflavin synthase, subunit alpha A6J74_24015 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) A6J74_24035 ENOG4108YM7 Gcn5-related n-acetyltransferase A6J74_24040 ENOG4105ETE Transcriptional regulator (LacI family A6J74_24050 ENOG4107SKW Inherit from COG: Alpha beta hydrolase A6J74_24070 ENOG4105RHY Pfam:UPF0157 A6J74_24075 ENOG4105CV8 reductase A6J74_24080 ENOG4105CPC Aldo Keto reductase A6J74_24100 ENOG4105MZ9 stage II sporulation protein m A6J74_24105 ENOG4105I3K Ferric uptake regulator, Fur family A6J74_24115 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A6J74_24140 ENOG4105D7N magnesium and cobalt transport protein CorA A6J74_24180 ENOG4105DVE abc transporter atp-binding protein A6J74_24185 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A6J74_24195 ENOG4105DZ1 carboxypeptidase A6J74_24200 ENOG41082AN stage II sporulation protein A6J74_24210 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6J74_24215 ENOG4105C8J )-transporter A6J74_24235 ENOG41090VF Stage v sporulation protein ac A6J74_24240 ENOG4105CZ3 stage V sporulation protein ad A6J74_24250 ENOG4105G6R Stage v sporulation protein ae A6J74_24260 ENOG4105J7I hydrolase A6J74_24265 ENOG4105PTM secreted protein A6J74_24270 ENOG4107ZE5 PPIases accelerate the folding of proteins A6J74_24310 ENOG4105CE4 GlcNAc 6-P deacetylase A6J74_24320 ENOG4105FDP GntR family transcriptional regulator A6J74_24330 ENOG4105CID antiterminator A6J74_24345 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A6J74_24365 ENOG4105BZU Histidine kinase A6J74_24375 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A6J74_24390 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) A6J74_24415 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A6J74_24435 ENOG4105DTD Dehydrogenase A6J74_24440 ENOG4105K7K Transcriptional regulator A6J74_24475 ENOG4105CHU acetyl-coa acetyltransferase A6J74_24525 ENOG4105CG3 alpha amylase, catalytic region A6J74_24535 ENOG4107FKK extracellular solute-binding protein family 1 A6J74_24545 ENOG4105EG2 ABC transporter, permease A6J74_24550 ENOG4105FKQ transcriptional regulator A6J74_24555 ENOG4105CHM Aminotransferase A6J74_24565 ENOG4108HGU Histidine kinase A6J74_24625 ENOG4105UIN A6J74_24635 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) A6J74_24650 ENOG4105K6S Short-chain dehydrogenase reductase Sdr A6J74_24655 ENOG4105EPM Diguanylate phosphodiesterase A6J74_24670 ENOG4107IN1 Protein of unknown function (DUF1797) A6J74_24680 ENOG4108XRC Protein of unknown function (DUF458) A6J74_24700 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) A6J74_24715 ENOG4107ZYR domain protein A6J74_24720 ENOG4105CN5 Metallo-Beta-Lactamase A6J74_24735 ENOG4108X4Q Hydrolase A6J74_24740 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A6J74_24755 ENOG4105CPP Dehydrogenase, E1 component A6J74_24775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A6J74_24815 ENOG4105CXN decarboxylase A6J74_24840 ENOG4105ECY inositol monophosphatase A6J74_24850 ENOG4105CI3 gtp-binding protein typa A6J74_24855 ENOG4105QA2 A6J74_24875 ENOG4108IAB Phoh family A6J74_24890 ENOG4105CNI cell division protein FtsW A6J74_24900 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) A6J74_24950 ENOG4106UY4 Inherit from COG: Scp-like extracellular A6J74_24965 ENOG4107TB6 phosphoglycerate mutase A6J74_24985 ENOG4106H78 methyltransferase A6J74_24995 ENOG4105H20 Sporulation integral membrane protein YlbJ A6J74_25000 ENOG4105D78 K07001 NTE family protein A6J74_25005 ENOG41063PX domain protein A6J74_25015 ENOG4105KNH Nucleic acid-binding protein A6J74_25055 ENOG4105CJN penicillin-binding protein A6J74_25060 ENOG4105CJN penicillin-binding protein A6J74_25065 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A6J74_25080 ENOG4105CNI cell division protein FtsW A6J74_25095 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) A6J74_25100 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A6J74_25105 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A6J74_25115 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A6J74_25125 ENOG4105WR5 sporulation protein, YlmC YmxH family A6J74_25130 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A6J74_25135 ENOG4105DFA alanine racemase domain protein A6J74_25140 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) A6J74_25145 ENOG41067XK integral membrane protein A6J74_25150 ENOG4105DBK s4 domain protein A6J74_25175 ENOG4105C34 Pseudouridine synthase A6J74_25210 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) A6J74_25255 ENOG4105DC7 peptidase M24 A6J74_25260 ENOG4105F23 Fibronectin-binding protein A6J74_25270 ENOG4105DSJ YicC domain protein A6J74_25290 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A6J74_25295 ENOG4105C25 Primosomal protein n' A6J74_25305 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A6J74_25310 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A6J74_25320 ENOG4108ZF3 Phosphatase A6J74_25325 ENOG4105D9P serine threonine protein kinase A6J74_25330 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A6J74_25335 ENOG4105DJV ribulose-phosphate 3-epimerase A6J74_25340 ENOG4105FJ0 thiamine A6J74_25355 ENOG4108ZAA Alkaline-shock protein A6J74_25360 ENOG4105DP4 dak2 domain fusion protein ylov A6J74_25365 ENOG4105CB5 ATP-dependent DNA helicase recG A6J74_25380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A6J74_25385 ENOG4105CHR reductase A6J74_25400 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) A6J74_25405 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A6J74_25425 ENOG4105VB6 UPF0109 protein A6J74_25450 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) A6J74_25465 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha A6J74_25470 ENOG4105C79 DNA protecting protein DprA A6J74_25475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A6J74_25485 ENOG4108HE4 integrase family A6J74_25510 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) A6J74_25525 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A6J74_25530 ENOG4105KNE Phosphatidate cytidylyltransferase A6J74_25540 ENOG4105DZP Membrane-associated zinc metalloprotease A6J74_25555 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A6J74_25565 ENOG4105CHV Transcription elongation factor NusA A6J74_25570 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination A6J74_25575 ENOG4105VHM ribosomal protein A6J74_25585 ENOG4105W7A Protein of unknown function (DUF503) A6J74_25600 ENOG4105DTN riboflavin biosynthesis protein ribF A6J74_25620 ENOG4105C1V Peptidase, M16 A6J74_25630 ENOG4105E35 Dipicolinate synthase subunit A A6J74_25635 ENOG4108S0H Dipicolinic acid synthetase, b subunit A6J74_25640 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A6J74_25650 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A6J74_25660 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit A6J74_25670 ENOG4107QZI cell division protein FtsK A6J74_25680 ENOG4105FDP GntR family transcriptional regulator A6J74_25685 ENOG4105DIH basic membrane A6J74_25690 ENOG4108JQ9 ABC transporter A6J74_25695 ENOG4105UIB (ABC) transporter A6J74_25715 ENOG4108RKS Short-chain dehydrogenase reductase Sdr A6J74_25720 ENOG4105XZV Protein of unknown function (DUF3243) A6J74_25735 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A6J74_25770 ENOG4105D48 metallophosphoesterase A6J74_25775 ENOG4105MCT stage V sporulation protein S A6J74_25780 ENOG4108IGT Dipeptidase A6J74_25785 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein A6J74_25790 ENOG4105DQU oxidoreductase, subunit beta A6J74_25815 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) A6J74_25830 ENOG4105E0M Sulfatase A6J74_25845 ENOG4105F0V Cell wall hydrolase A6J74_25870 ENOG4107YEI lmbE family A6J74_25875 ENOG4107TTQ Alpha beta hydrolase fold A6J74_25890 ENOG41067MG lrgb family A6J74_25910 ENOG4105C5E polysaccharide biosynthesis protein A6J74_25930 ENOG4105BZU Histidine kinase A6J74_25960 ENOG4105D03 DNA-3-methyladenine glycosylase II A6J74_25965 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A6J74_25975 ENOG4105CGK Exodeoxyribonuclease III A6J74_25995 ENOG4105E0A ABC, transporter A6J74_26000 ENOG4105NIV Esterase A6J74_26020 ENOG4105VPX protein, conserved in bacteria A6J74_26025 ENOG410681U heavy metal transport detoxification protein A6J74_26030 ENOG4105C59 p-type ATPase A6J74_26070 ENOG4105C85 amino acid A6J74_26085 ENOG4108SJC Membrane A6J74_26090 ENOG4107QW4 alcohol dehydrogenase A6J74_26095 ENOG4105E98 transcriptional regulator DeoR family A6J74_26100 ENOG4105DE4 1-phosphofructokinase A6J74_26105 ENOG4105DM4 PTS System A6J74_26110 ENOG41069ER domain protein A6J74_26150 ENOG4105EN6 Membrane A6J74_26155 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A6J74_26160 ENOG4105CXI aluminum resistance protein A6J74_26165 ENOG4105KV4 Transcriptional regulator A6J74_26170 ENOG4105C5F glutamine synthetase A6J74_26300 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A6J74_26450 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A6J74_26515 ENOG4105E4C Lytic transglycosylase catalytic A6J74_26535 ENOG4107YJ4 chain length determinant protein A6J74_26545 ENOG4108PQP glycosyl transferase group 1 A6J74_26550 ENOG4108KMV Glycosyl transferase (Group 1 A6J74_26555 ENOG4107SJB teichoic acid biosynthesis A6J74_26560 ENOG41068W6 Capsular polysaccharide biosynthesis protein A6J74_26565 ENOG4108KMV Glycosyl transferase (Group 1 A6J74_26605 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A6J74_26610 ENOG4105CAQ asparagine synthetase A6J74_26635 ENOG4105BZ1 (ABC) transporter A6J74_26640 ENOG4105K7K Transcriptional regulator A6J74_26660 ENOG4108SVB resolvase A6J74_26670 ENOG4105CGH 5'-nucleotidase A6J74_26710 ENOG4105BZ1 (ABC) transporter A6J74_26715 ENOG4105BZ1 (ABC) transporter A6J74_26755 ENOG4108Z4K mutator MutT protein A6J74_26760 ENOG41067MG lrgb family A6J74_26770 ENOG4107RSM transcriptional regulator A6J74_26785 ENOG4105CJ1 ABC, transporter A6J74_26795 ENOG4105CH2 amidohydrolase A6J74_26810 ENOG4107QIV Cytochrome c biogenesis protein A6J74_26845 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A6J74_26870 ENOG4108903 Formimidoylglutamase A6J74_26875 ENOG4108VJ1 Transcriptional regulator (CarD family A6J74_26880 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A6J74_26885 ENOG4105CBC glutamate synthase A6J74_26890 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase A6J74_26895 ENOG4105FBA Phospholipase Carboxylesterase A6J74_26900 ENOG4105BZU Histidine kinase A6J74_26910 ENOG4107AYK membrAne A6J74_26950 ENOG4108IMY Transcriptional regulator A6J74_26955 ENOG4105CEY Amp-dependent synthetase and ligase A6J74_26960 ENOG4107ZYJ bioY protein A6J74_26965 ENOG4107F3J Amp-dependent synthetase and ligase A6J74_26985 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A6J74_26995 ENOG4105E5W Transporter A6J74_27025 ENOG4108I0Z Aconitate hydratase A6J74_27030 ENOG4105BZ1 (ABC) transporter A6J74_27040 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A6J74_27045 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A6J74_27070 ENOG4105W8X HesB YadR YfhF-family protein A6J74_27075 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A6J74_27080 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase A6J74_27085 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) A6J74_27090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_27095 ENOG4105C0H protease A6J74_27100 ENOG4105K4P CoA-binding domain protein A6J74_27110 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A6J74_27120 ENOG4105D9R oxidoreductase A6J74_27130 ENOG4105CIG ABC transporter A6J74_27140 ENOG4105EMN RNA polymerase sigma factor A6J74_27150 ENOG4108KGH TRANSCRIPTIONal A6J74_27155 ENOG4107QJT sodium dicarboxylate symporter A6J74_27210 ENOG4105CUB amino acid A6J74_27215 ENOG4108NHD germination protein A6J74_27230 ENOG4108JB9 formate dehydrogenase A6J74_27240 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) A6J74_27245 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A6J74_27260 ENOG4105TMB Formate nitrite transporter A6J74_27265 ENOG4105D06 uba thif-type nad fad binding protein A6J74_27270 ENOG4105CVM Molybdenum cofactor synthesis domain protein A6J74_27275 ENOG4108ZAF Molybdopterin A6J74_27285 ENOG4105D1F ATP-binding protein A6J74_27300 ENOG410696E Membrane A6J74_27305 ENOG4105FR1 rard protein A6J74_27315 ENOG4105EWU Squalene--hopene cyclase A6J74_27325 ENOG4105CHR reductase A6J74_27330 ENOG4105C26 Dehydrogenase A6J74_27340 ENOG4108IA2 Sodium pantothenate symporter A6J74_27355 ENOG4106IQC argininosuccinate lyase A6J74_27365 ENOG410904N short-chain dehydrogenase reductase A6J74_27405 ENOG4105VEQ Cold shock protein A6J74_27420 ENOG4108R1P A6J74_27430 ENOG41073R8 VanW family A6J74_27435 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_27445 ENOG4105KT7 mgtC SapB transporter A6J74_27455 ENOG4105BZU Histidine kinase A6J74_27485 ENOG4108VXD carboxy-peptidase A6J74_27500 ENOG4105BZU Histidine kinase A6J74_27510 ENOG4105VRS hydrolase family 18 A6J74_27525 ENOG4105CQB FAD linked oxidase domain protein A6J74_27565 ENOG4105CIS alcohol dehydrogenase A6J74_27570 ENOG41082BM Transcriptional regulator, arsr family A6J74_27580 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A6J74_27590 ENOG4105EGI Transcriptional regulator A6J74_27605 ENOG4108A04 Beta-lactamase A6J74_27620 ENOG4105FFC UPF0187 protein A6J74_27650 ENOG4105DPN Oligoendopeptidase f A6J74_27655 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase A6J74_27660 ENOG4105E5K Alpha-amylase A6J74_27665 ENOG4105C98 muts2 protein A6J74_27685 ENOG4107V2S Transcriptional regulator A6J74_27695 ENOG4107CUJ Protein of unknown function (DUF2690) A6J74_27715 ENOG4105NX3 Membrane A6J74_27720 ENOG4105DQ5 transport system permease protein A6J74_27725 ENOG4105EHG Permease protein A6J74_27730 ENOG4108MES Periplasmic binding protein A6J74_27735 ENOG4105WCN acetyltransferase A6J74_27745 ENOG4107R3E Citrate transporter A6J74_27755 ENOG4108TN2 lmbE family A6J74_27810 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) A6J74_27820 ENOG4105CIS alcohol dehydrogenase A6J74_27855 ENOG4105H3G oxidoreductase A6J74_27890 ENOG4107YXZ hydrolase, family 25 A6J74_27905 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) A6J74_27985 ENOG4108ZJ4 polysaccharide deacetylase A6J74_28015 ENOG4105KVH Transcriptional regulator A6J74_28020 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A6J74_28080 ENOG4105D9R oxidoreductase A6J74_28085 ENOG4108TZY GntR Family Transcriptional Regulator A6J74_28090 ENOG4105KVH Transcriptional regulator A6J74_28130 ENOG4105VMP Transcriptional regulator A6J74_28135 ENOG4105C44 Serine transporter A6J74_28155 ENOG41090KN UPF0303 protein A6J74_28190 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A6J74_28210 ENOG4105C6Z Gluconate A6J74_28220 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) A6J74_28225 ENOG4105XDF Protein of unknown function (DUF1272) A6J74_28230 ENOG4105DDN Pentapeptide repeat-containing protein A6J74_28255 ENOG4105FAW cDP-glucose 4,6-dehydratase A6J74_28260 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase A6J74_28275 ENOG4105C37 (CBS) domain A6J74_28310 ENOG4105EV4 Multidrug resistance protein mdtH A6J74_28350 ENOG4105C31 Tryptophanyl-tRNA synthetase A6J74_28355 ENOG4108UW5 maltose o-acetyltransferase A6J74_28365 ENOG4105DKQ ROK family A6J74_28370 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_28445 ENOG4108PSK reductase A6J74_28485 ENOG4108RCM Nitroreductase A6J74_28490 ENOG4105KVH Transcriptional regulator A6J74_28510 ENOG4108Z66 YbaK ebsC protein A6J74_28515 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) A6J74_28525 ENOG4108K8S endonuclease I A6J74_28585 ENOG4105DYS nad(p)h dehydrogenase (quinone) A6J74_28595 ENOG4105CRW Short chain fatty acid transporter A6J74_28635 ENOG4105CZM Major Facilitator A6J74_28640 ENOG4107MII Sugar-specific transcriptional regulator TrmB A6J74_28655 ENOG4108ISG Major Facilitator A6J74_28670 ENOG4105MWK D-amino acid dehydrogenase, small subunit A6J74_28675 ENOG4105C26 Dehydrogenase A6J74_28680 ENOG4105C3S Mate efflux family protein A6J74_28695 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A6J74_28705 ENOG4105PNM synthesis protein A6J74_28710 ENOG4108VXD carboxy-peptidase A6J74_28780 ENOG4108IG5 Transcriptional regulator A6J74_28825 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A6J74_28830 ENOG4108JQ1 Dehydrogenase A6J74_28850 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A6J74_28865 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A6J74_28875 ENOG4105BZU Histidine kinase A6J74_28895 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) A6J74_28915 ENOG4105JQZ Methyltransferase A6J74_28935 ENOG4105K6H D-cysteine desulfhydrase A6J74_28940 ENOG4105C0R drug resistance transporter emrb qaca subfamily A6J74_28945 ENOG4107ZY0 Phenazine biosynthesis-like protein A6J74_28950 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A6J74_29000 ENOG4105N0V mono-oxygenase ydhR A6J74_29030 ENOG4108YXU transcriptional regulator AsnC family A6J74_29035 ENOG4105CHR reductase A6J74_29045 ENOG4105E1K spore germination protein A6J74_29065 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) A6J74_29075 ENOG4108IG5 Transcriptional regulator A6J74_29090 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) A6J74_29110 ENOG41085FC arsR family transcriptional regulator A6J74_29115 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase A6J74_29120 ENOG4105D6J arsenicaL-resistance protein A6J74_29155 ENOG4107ZQN disulfide bond A6J74_29160 ENOG4108KF3 Electron transport protein SCO1 SenC A6J74_29175 ENOG4105DIK (ABC) transporter A6J74_29180 ENOG4105CC5 ABC transporter A6J74_29185 ENOG4105DSE periplasmic solute binding protein A6J74_29190 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A6J74_29195 ENOG4108U7W acetyltransferase A6J74_29205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A6J74_29210 ENOG4105BZU Histidine kinase A6J74_29220 ENOG4107VMI polysaccharide deacetylase A6J74_29240 ENOG4106P55 Transcriptional regulator A6J74_29245 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) A6J74_29250 ENOG4105GPN Uncharacterized conserved protein (DUF2294) A6J74_29255 ENOG4108TWJ NADH dehydrogenase subunit 5 A6J74_29270 ENOG4105CVP deoxyribo-dipyrimidine photolyase A6J74_29275 ENOG4108606 TspO/MBR family A6J74_29315 ENOG41090MY MarR family Transcriptional regulator A6J74_29340 ENOG4105CHJ isochorismatase hydrolase A6J74_29355 ENOG4105CGH 5'-nucleotidase A6J74_29360 ENOG4108VXD carboxy-peptidase A6J74_29375 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A6J74_29390 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A6J74_29440 ENOG4105DWD nucleoside recognition domain protein A6J74_29460 ENOG4105FDT acyl-CoA dehydrogenase A6J74_29470 ENOG4106N3A copper homeostasis protein cutc A6J74_29490 ENOG4107258 Transcriptional regulator A6J74_29495 ENOG4105P4J Allophanate hydrolase, subunit 1 A6J74_29505 ENOG4105E7W lamb ycsf family protein A6J74_29525 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A6J74_29530 ENOG4107RF6 penicillin-binding protein A6J74_29565 ENOG4105F1N DNA alkylation repair A6J74_29575 ENOG4108IQI permease A6J74_29585 ENOG410635A Membrane A6J74_29620 ENOG4107XJU UPF0178 protein A6J74_29650 ENOG4108XET gCN5-related N-acetyltransferase A6J74_29655 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) A6J74_29685 ENOG4105WEC Molybdate metabolism regulator A6J74_29715 ENOG4105FS7 Transcriptional regulator A6J74_29720 ENOG4108TVJ Nitroreductase A6J74_29740 ENOG4108IBT Inherit from COG: transposase A6J74_30125 ENOG4106F1P AAA ATPase, central domain protein A6J74_30140 ENOG4105D3Q Sugar transferase A6J74_30145 ENOG4105CPF Cell wall formation (By similarity)