locus-tag	class	description
A6J74_00020	COG0772	Belongs to the SEDS family
A6J74_00025	COG0741	lytic transglycosylase activity
A6J74_00040	COG0577	efflux transmembrane transporter activity
A6J74_00045	COG1136	(ABC) transporter
A6J74_00080	COG2318	DinB family
A6J74_00085	COG2378	regulation of single-species biofilm formation
A6J74_00190	COG0791	NLP P60 protein
A6J74_00190	COG3883	PFAM NLP P60 protein
A6J74_00470	COG1923	regulation of RNA biosynthetic process
A6J74_00475	COG0640	Transcriptional regulator
A6J74_00480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6J74_00515	COG3227	Zinc metalloprotease (Elastase)
A6J74_00525	COG1957	nucleoside hydrolase
A6J74_00550	COG1131	(ABC) transporter
A6J74_00565	COG1999	signal sequence binding
A6J74_00570	COG0662	Cupin 2, conserved barrel domain protein
A6J74_00580	COG0010	Belongs to the arginase family
A6J74_00590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J74_00605	COG0456	acetyltransferase
A6J74_00630	COG3290	protein histidine kinase activity
A6J74_00635	COG4565	transcriptional regulatory protein
A6J74_00650	COG1136	(ABC) transporter
A6J74_00655	COG0577	efflux transmembrane transporter activity
A6J74_00665	COG0745	RESPONSE REGULATOR receiver
A6J74_00670	COG2205	protein histidine kinase activity
A6J74_00675	COG0753	catalase activity
A6J74_00695	COG0745	RESPONSE REGULATOR receiver
A6J74_00730	COG1136	(ABC) transporter
A6J74_00780	COG0640	Transcriptional regulator
A6J74_00785	COG0346	lactoylglutathione lyase activity
A6J74_00790	COG0798	PFAM Bile acid sodium symporter
A6J74_00830	COG2226	methyltransferase
A6J74_00840	COG4555	ABC transporter
A6J74_00860	COG0720	synthase
A6J74_00870	COG0302	gtp cyclohydrolase
A6J74_00940	COG4974	Belongs to the 'phage' integrase family
A6J74_00945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J74_00965	COG0583	DNA-binding transcription factor activity
A6J74_00995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J74_01010	COG5002	protein histidine kinase activity
A6J74_01020	COG3338	carbonate dehydratase activity
A6J74_01040	COG2755	lipolytic protein G-D-S-L family
A6J74_01040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J74_01050	COG0726	polysaccharide deacetylase
A6J74_01055	COG0686	Belongs to the AlaDH PNT family
A6J74_01060	COG2508	Transcriptional regulator
A6J74_01060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A6J74_01130	COG1329	Transcriptional regulator
A6J74_01230	COG0358	DNA primase activity
A6J74_01235	COG1132	(ABC) transporter
A6J74_01305	COG3011	Protein conserved in bacteria
A6J74_01455	COG1923	regulation of RNA biosynthetic process
A6J74_01535	COG0753	catalase activity
A6J74_01565	COG0714	Associated with various cellular activities
A6J74_01590	COG0346	lactoylglutathione lyase activity
A6J74_01595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_01620	COG3655	Transcriptional regulator
A6J74_01630	COG1349	DNA-binding transcription factor activity
A6J74_01635	COG1175	transmembrane transport
A6J74_01660	COG3842	ATPase activity
A6J74_01670	COG1785	Belongs to the alkaline phosphatase family
A6J74_01675	COG2720	vancomycin resistance protein
A6J74_01680	COG3239	Fatty acid desaturase
A6J74_01690	COG0833	amino acid
A6J74_01700	COG1414	Transcriptional regulator
A6J74_01705	COG4187	Peptidase family M20/M25/M40
A6J74_01710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J74_01730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J74_01735	COG2207	Transcriptional regulator
A6J74_01760	COG2329	Antibiotic biosynthesis monooxygenase
A6J74_01790	COG1070	Carbohydrate kinase
A6J74_01795	COG2390	Transcriptional regulator
A6J74_01805	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J74_01810	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J74_01835	COG0431	NADPH-dependent FMN reductase
A6J74_01840	COG0519	Catalyzes the synthesis of GMP from XMP
A6J74_01845	COG0346	lactoylglutathione lyase activity
A6J74_01855	COG1388	LysM domain
A6J74_01855	COG3584	3D domain protein
A6J74_01900	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6J74_01900	COG1605	Chorismate mutase
A6J74_01920	COG0287	Prephenate dehydrogenase
A6J74_01935	COG1051	belongs to the nudix hydrolase family
A6J74_01940	COG1309	transcriptional regulator
A6J74_01945	COG1033	growth of symbiont in host cell
A6J74_01945	COG2409	Drug exporters of the RND superfamily
A6J74_01950	COG0488	(ABC) transporter
A6J74_01955	COG1368	sulfuric ester hydrolase activity
A6J74_01960	COG0861	Integral membrane protein TerC family
A6J74_01965	COG2814	Major facilitator Superfamily
A6J74_01980	COG0726	polysaccharide deacetylase
A6J74_01990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_01995	COG0346	lactoylglutathione lyase activity
A6J74_02000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6J74_02030	COG2318	DinB family
A6J74_02035	COG0697	spore germination
A6J74_02070	COG2746	aminoglycoside 3-N-acetyltransferase activity
A6J74_02100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J74_02105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J74_02110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J74_02125	COG0628	permease
A6J74_02175	COG1131	(ABC) transporter
A6J74_02190	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6J74_02200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J74_02205	COG0436	Aminotransferase
A6J74_02245	COG2226	methyltransferase
A6J74_02260	COG2261	transglycosylase associated protein
A6J74_02285	COG2814	Major facilitator Superfamily
A6J74_02285	COG0477	Major facilitator Superfamily
A6J74_02290	COG4533	DNA binding
A6J74_02295	COG0789	Transcriptional regulator
A6J74_02300	COG1664	Polymer-forming cytoskeletal
A6J74_02310	COG2814	Major facilitator Superfamily
A6J74_02360	COG1307	EDD domain protein, DegV family
A6J74_02365	COG0456	acetyltransferase
A6J74_02370	COG1164	Oligoendopeptidase f
A6J74_02395	COG0745	RESPONSE REGULATOR receiver
A6J74_02400	COG3850	Histidine kinase
A6J74_02400	COG5002	protein histidine kinase activity
A6J74_02405	COG2936	dipeptidyl-peptidase activity
A6J74_02455	COG4948	Mandelate Racemase Muconate Lactonizing
A6J74_02465	COG4166	transmembrane transport
A6J74_02470	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6J74_02485	COG0586	Pfam SNARE associated Golgi protein
A6J74_02490	COG1078	dGTPase activity
A6J74_02540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J74_02545	COG3938	Belongs to the proline racemase family
A6J74_02550	COG3938	Belongs to the proline racemase family
A6J74_02555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J74_02560	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_02565	COG1115	amino acid carrier protein
A6J74_02570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J74_02575	COG1162	GTPase activity
A6J74_02590	COG2318	DinB family
A6J74_02595	COG3397	chitin binding
A6J74_02610	COG4637	Psort location Cytoplasmic, score
A6J74_02640	COG0514	ATP-dependent DNA helicase (RecQ)
A6J74_02650	COG3973	AAA domain
A6J74_02700	COG2315	Protein conserved in bacteria
A6J74_02705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J74_02710	COG2205	protein histidine kinase activity
A6J74_02720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J74_02730	COG1819	glycosyl
A6J74_02740	COG3397	chitin binding
A6J74_02755	COG2153	protein acetylation
A6J74_02785	COG0517	IMP dehydrogenase activity
A6J74_02785	COG4175	Glycine betaine
A6J74_02790	COG4176	ABC-type proline glycine betaine transport system permease component
A6J74_02820	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_02830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J74_02835	COG0022	dehydrogenase e1 component
A6J74_02840	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J74_02845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J74_02870	COG1349	DNA-binding transcription factor activity
A6J74_02890	COG3284	Transcriptional regulator
A6J74_02900	COG1309	transcriptional regulator
A6J74_02935	COG3409	Peptidoglycan-binding domain 1 protein
A6J74_02935	COG3773	Cell wall hydrolase
A6J74_02940	COG2959	enzyme of heme biosynthesis
A6J74_02955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_02990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_02995	COG0697	spore germination
A6J74_03000	COG0201	protein transport
A6J74_03010	COG0737	Belongs to the 5'-nucleotidase family
A6J74_03015	COG3227	Zinc metalloprotease (Elastase)
A6J74_03020	COG1523	belongs to the glycosyl hydrolase 13 family
A6J74_03040	COG0076	glutamate decarboxylase activity
A6J74_03065	COG0577	efflux transmembrane transporter activity
A6J74_03070	COG1136	(ABC) transporter
A6J74_03110	COG5002	protein histidine kinase activity
A6J74_03115	COG0745	RESPONSE REGULATOR receiver
A6J74_03145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J74_03175	COG0322	excinuclease ABC activity
A6J74_03215	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J74_03240	COG3878	Protein conserved in bacteria
A6J74_03265	COG0592	DNA-directed DNA polymerase activity
A6J74_03270	COG2816	NAD+ diphosphatase activity
A6J74_03280	COG2223	nitrite transmembrane transporter activity
A6J74_03320	COG0697	spore germination
A6J74_03325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_03345	COG0584	glycerophosphoryl diester phosphodiesterase
A6J74_03365	COG2814	Major facilitator Superfamily
A6J74_03435	COG0671	phosphoesterase, PA-phosphatase related
A6J74_03440	COG0604	alcohol dehydrogenase
A6J74_03455	COG2205	protein histidine kinase activity
A6J74_03480	COG1794	racemase activity, acting on amino acids and derivatives
A6J74_03485	COG1819	glycosyl
A6J74_03500	COG5002	protein histidine kinase activity
A6J74_03510	COG0561	phosphatase activity
A6J74_03545	COG2124	cytochrome p450
A6J74_03630	COG5632	N-Acetylmuramoyl-L-alanine amidase
A6J74_03705	COG0740	serine-type endopeptidase activity
A6J74_03715	COG4626	Terminase
A6J74_03715	COG1802	Transcriptional regulator
A6J74_03745	COG0582	viral genome integration into host DNA
A6J74_03750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6J74_03815	COG1484	DNA-dependent DNA replication
A6J74_03860	COG0582	viral genome integration into host DNA
A6J74_03915	COG0582	viral genome integration into host DNA
A6J74_04055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6J74_04065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_04095	COG0577	efflux transmembrane transporter activity
A6J74_04100	COG1136	(ABC) transporter
A6J74_04115	COG0667	Aldo Keto reductase
A6J74_04120	COG0583	DNA-binding transcription factor activity
A6J74_04130	COG2205	protein histidine kinase activity
A6J74_04135	COG0745	RESPONSE REGULATOR receiver
A6J74_04150	COG3773	Cell wall hydrolase
A6J74_04155	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A6J74_04165	COG3386	PFAM SMP-30 Gluconolaconase
A6J74_04175	COG0693	protein deglycase activity
A6J74_04185	COG2323	membrane
A6J74_04210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_04215	COG0697	spore germination
A6J74_04240	COG0583	DNA-binding transcription factor activity
A6J74_04245	COG1942	4-Oxalocrotonate Tautomerase
A6J74_04255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J74_04265	COG2226	methyltransferase
A6J74_04270	COG1733	regulation of RNA biosynthetic process
A6J74_04285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J74_04315	COG2207	Transcriptional regulator
A6J74_04320	COG3227	Zinc metalloprotease (Elastase)
A6J74_04345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J74_04375	COG1686	Belongs to the peptidase S11 family
A6J74_04380	COG2318	DinB family
A6J74_04440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J74_04445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A6J74_04450	COG1024	Enoyl-CoA hydratase
A6J74_04455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J74_04460	COG0511	ligase activity, forming carbon-carbon bonds
A6J74_04465	COG0439	Biotin carboxylase
A6J74_04470	COG1960	acyl-CoA dehydrogenase activity
A6J74_04480	COG1309	transcriptional regulator
A6J74_04490	COG1131	(ABC) transporter
A6J74_04515	COG0823	Involved in the tonB-independent uptake of proteins
A6J74_04520	COG3397	chitin binding
A6J74_04535	COG0697	spore germination
A6J74_04550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_04595	COG1595	DNA-templated transcription, initiation
A6J74_04600	COG0768	penicillin binding
A6J74_04620	COG1686	Belongs to the peptidase S11 family
A6J74_04625	COG0110	maltose O-acetyltransferase activity
A6J74_04630	COG0730	response to heat
A6J74_04640	COG2002	toxin-antitoxin pair type II binding
A6J74_04670	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J74_04710	COG3961	Belongs to the TPP enzyme family
A6J74_04715	COG2226	methyltransferase
A6J74_04745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_04785	COG2971	BadF BadG BcrA BcrD
A6J74_04810	COG1649	PFAM Uncharacterised BCR, COG1649
A6J74_04835	COG1595	DNA-templated transcription, initiation
A6J74_04875	COG1396	sequence-specific DNA binding
A6J74_04890	COG1132	(ABC) transporter
A6J74_04895	COG1132	(ABC) transporter
A6J74_04910	COG2258	MOSC domain
A6J74_04915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J74_04920	COG0583	DNA-binding transcription factor activity
A6J74_04925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J74_04930	COG0583	DNA-binding transcription factor activity
A6J74_04960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_04995	COG1247	-acetyltransferase
A6J74_05020	COG1309	transcriptional regulator
A6J74_05025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_05035	COG1846	Transcriptional regulator
A6J74_05055	COG0745	RESPONSE REGULATOR receiver
A6J74_05065	COG5002	protein histidine kinase activity
A6J74_05080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J74_05080	COG2755	lipolytic protein G-D-S-L family
A6J74_05105	COG2207	Transcriptional regulator
A6J74_05115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J74_05150	COG0028	Belongs to the TPP enzyme family
A6J74_05165	COG0596	Alpha beta hydrolase
A6J74_05175	COG1136	(ABC) transporter
A6J74_05180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6J74_05185	COG1187	pseudouridine synthase activity
A6J74_05190	COG2329	Antibiotic biosynthesis monooxygenase
A6J74_05205	COG1115	amino acid carrier protein
A6J74_05230	COG2318	DinB family
A6J74_05240	COG0776	regulation of translation
A6J74_05255	COG2814	Major facilitator Superfamily
A6J74_05260	COG3251	PFAM MbtH domain protein
A6J74_05265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6J74_05270	COG1535	isochorismatase
A6J74_05270	COG3433	isochorismatase activity
A6J74_05275	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6J74_05280	COG1169	isochorismate synthase
A6J74_05285	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_05290	COG2223	nitrite transmembrane transporter activity
A6J74_05325	COG0420	3'-5' exonuclease activity
A6J74_05340	COG1024	Enoyl-CoA hydratase
A6J74_05345	COG1280	lysine exporter protein (LysE YggA)
A6J74_05355	COG2084	Dehydrogenase
A6J74_05360	COG1960	acyl-CoA dehydrogenase activity
A6J74_05365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6J74_05370	COG2079	MmgE PrpD family protein
A6J74_05375	COG0372	Belongs to the citrate synthase family
A6J74_05385	COG2814	Major facilitator Superfamily
A6J74_05395	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J74_05395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J74_05415	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_05440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J74_05495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J74_05500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J74_05505	COG0671	phosphoesterase, PA-phosphatase related
A6J74_05515	COG4991	sh3 domain protein
A6J74_05515	COG0515	serine threonine protein kinase
A6J74_05515	COG3064	Membrane
A6J74_05550	COG1509	lysine 2,3-aminomutase activity
A6J74_05555	COG3829	transcription factor binding
A6J74_05560	COG0456	acetyltransferase
A6J74_05565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J74_05570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A6J74_05575	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6J74_05580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J74_05600	COG5506	Protein of unknown function (DUF1694)
A6J74_05605	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_05610	COG1253	flavin adenine dinucleotide binding
A6J74_05645	COG1174	glycine betaine transport
A6J74_05650	COG1125	glycine betaine transport
A6J74_05650	COG0517	IMP dehydrogenase activity
A6J74_05685	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A6J74_05695	COG1070	Carbohydrate kinase
A6J74_05725	COG1064	alcohol dehydrogenase
A6J74_05730	COG1737	Transcriptional regulator
A6J74_05735	COG2197	response regulator
A6J74_05740	COG4585	Histidine kinase
A6J74_05740	COG2203	Gaf domain
A6J74_05745	COG0668	transmembrane transport
A6J74_05750	COG1051	belongs to the nudix hydrolase family
A6J74_05755	COG1335	isochorismatase
A6J74_05775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J74_05780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J74_05785	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J74_05800	COG0367	asparagine synthase
A6J74_05805	COG0071	Belongs to the small heat shock protein (HSP20) family
A6J74_05810	COG1999	signal sequence binding
A6J74_05815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6J74_05820	COG1307	EDD domain protein, DegV family
A6J74_05830	COG0805	protein transport
A6J74_05840	COG1272	protein, Hemolysin III
A6J74_05845	COG0204	Acyl-transferase
A6J74_05855	COG0768	penicillin binding
A6J74_05870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J74_05885	COG0546	phosphoglycolate phosphatase activity
A6J74_05900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J74_05905	COG0456	acetyltransferase
A6J74_05915	COG1794	racemase activity, acting on amino acids and derivatives
A6J74_05925	COG2610	gluconate transmembrane transporter activity
A6J74_05950	COG0733	neurotransmitter:sodium symporter activity
A6J74_05955	COG0017	Asparaginyl-tRNA synthetase
A6J74_05990	COG0018	arginyl-trna synthetase
A6J74_05995	COG2136	Putative SAM-dependent methyltransferase
A6J74_05995	COG2521	methyltransferase
A6J74_06010	COG1413	lyase activity
A6J74_06025	COG0629	single-stranded DNA binding
A6J74_06040	COG0488	(ABC) transporter
A6J74_06045	COG1418	mRNA catabolic process
A6J74_06055	COG2359	stage V sporulation protein S
A6J74_06095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J74_06100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_06115	COG0582	viral genome integration into host DNA
A6J74_06145	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A6J74_06150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6J74_06155	COG2146	nitrite reductase [NAD(P)H] activity
A6J74_06160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J74_06160	COG1587	Uroporphyrinogen-III synthase
A6J74_06185	COG2223	nitrite transmembrane transporter activity
A6J74_06195	COG0314	molybdopterin synthase activity
A6J74_06200	COG0303	'Molybdopterin
A6J74_06205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J74_06210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6J74_06215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J74_06220	COG2181	nitrate reductase activity
A6J74_06225	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A6J74_06230	COG1140	nitrate reductase beta subunit
A6J74_06235	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A6J74_06240	COG0714	Associated with various cellular activities
A6J74_06245	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A6J74_06250	COG1305	Transglutaminase-like
A6J74_06255	COG0386	Belongs to the glutathione peroxidase family
A6J74_06265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6J74_06265	COG0426	domain, Protein
A6J74_06285	COG1595	DNA-templated transcription, initiation
A6J74_06300	COG0346	lactoylglutathione lyase activity
A6J74_06320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J74_06345	COG3874	Sporulation protein YtfJ
A6J74_06355	COG4974	Belongs to the 'phage' integrase family
A6J74_06510	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J74_06525	COG0842	Transport permease protein
A6J74_06525	COG1511	domain protein
A6J74_06545	COG0456	acetyltransferase
A6J74_06570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_06575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_06580	COG1819	glycosyl
A6J74_06595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J74_06605	COG2814	Major facilitator Superfamily
A6J74_06610	COG1846	Transcriptional regulator
A6J74_06615	COG0561	phosphatase activity
A6J74_06625	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J74_06640	COG2211	Major facilitator Superfamily
A6J74_06655	COG1876	peptidase activity
A6J74_06670	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J74_06690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J74_06695	COG1114	Component of the transport system for branched-chain amino acids
A6J74_06710	COG1253	flavin adenine dinucleotide binding
A6J74_06715	COG2839	Protein conserved in bacteria
A6J74_06720	COG0702	epimerase
A6J74_06735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J74_06745	COG1607	acyl-coa hydrolase
A6J74_06750	COG3689	TIGRFAM TIGR03943 family protein
A6J74_06755	COG0701	Predicted permease
A6J74_06765	COG2244	polysaccharide biosynthetic process
A6J74_06770	COG0586	Pfam SNARE associated Golgi protein
A6J74_06775	COG1051	belongs to the nudix hydrolase family
A6J74_06780	COG5337	Spore coat protein CotH
A6J74_06790	COG0406	alpha-ribazole phosphatase activity
A6J74_06805	COG4166	transmembrane transport
A6J74_06815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J74_06825	COG0702	epimerase
A6J74_06835	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J74_06845	COG0523	cobalamin synthesis protein
A6J74_06850	COG4989	oxidoreductase activity
A6J74_06855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_06860	COG1231	oxidoreductase activity
A6J74_06870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J74_06885	COG0783	Belongs to the Dps family
A6J74_06895	COG3949	Membrane
A6J74_06940	COG0667	Aldo Keto reductase
A6J74_06945	COG0640	Transcriptional regulator
A6J74_06950	COG1404	Belongs to the peptidase S8 family
A6J74_06955	COG2002	toxin-antitoxin pair type II binding
A6J74_06960	COG0577	efflux transmembrane transporter activity
A6J74_06995	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6J74_07005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_07010	COG1279	arginine transmembrane transporter activity
A6J74_07015	COG2814	Major facilitator Superfamily
A6J74_07025	COG1082	Xylose isomerase domain protein TIM barrel
A6J74_07040	COG0318	PFAM AMP-dependent synthetase and ligase
A6J74_07045	COG4264	IucA IucC family
A6J74_07055	COG1247	-acetyltransferase
A6J74_07060	COG1285	pathogenesis
A6J74_07070	COG0726	polysaccharide deacetylase
A6J74_07075	COG5002	protein histidine kinase activity
A6J74_07080	COG0745	RESPONSE REGULATOR receiver
A6J74_07090	COG1316	TRANSCRIPTIONal
A6J74_07115	COG0460	homoserine dehydrogenase
A6J74_07130	COG5658	integral membrane protein
A6J74_07135	COG0726	polysaccharide deacetylase
A6J74_07155	COG0300	oxidoreductase activity
A6J74_07160	COG5002	protein histidine kinase activity
A6J74_07165	COG0745	RESPONSE REGULATOR receiver
A6J74_07170	COG1132	(ABC) transporter
A6J74_07180	COG1388	LysM domain
A6J74_07180	COG0791	NLP P60 protein
A6J74_07195	COG1686	Belongs to the peptidase S11 family
A6J74_07215	COG1216	Glycosyl transferase, family 2
A6J74_07220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6J74_07225	COG4988	ABC transporter
A6J74_07230	COG1294	oxidase, subunit
A6J74_07235	COG1271	oxidase subunit
A6J74_07260	COG0583	DNA-binding transcription factor activity
A6J74_07280	COG0411	ABC transporter
A6J74_07290	COG0523	cobalamin synthesis protein
A6J74_07295	COG1231	oxidoreductase activity
A6J74_07310	COG0628	permease
A6J74_07325	COG0778	Nitroreductase
A6J74_07330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6J74_07335	COG1959	2 iron, 2 sulfur cluster binding
A6J74_07340	COG0583	DNA-binding transcription factor activity
A6J74_07345	COG0697	spore germination
A6J74_07350	COG4549	nuclear export factor GLE1
A6J74_07355	COG2372	response to copper ion
A6J74_07355	COG1276	copper resistance
A6J74_07365	COG1114	Component of the transport system for branched-chain amino acids
A6J74_07385	COG0583	DNA-binding transcription factor activity
A6J74_07425	COG1073	alpha beta
A6J74_07455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J74_07465	COG2239	Acts as a magnesium transporter
A6J74_07470	COG0772	Belongs to the SEDS family
A6J74_07500	COG2205	protein histidine kinase activity
A6J74_07505	COG0745	RESPONSE REGULATOR receiver
A6J74_07510	COG0577	efflux transmembrane transporter activity
A6J74_07515	COG1136	(ABC) transporter
A6J74_07535	COG0814	amino acid
A6J74_07540	COG1760	l-serine dehydratase
A6J74_07545	COG1760	l-serine dehydratase
A6J74_07595	COG1073	alpha beta
A6J74_07605	COG2132	Multicopper oxidase
A6J74_07610	COG0006	proline dipeptidase activity
A6J74_07625	COG0583	DNA-binding transcription factor activity
A6J74_07645	COG4846	Membrane protein involved in cytochrome C biogenesis
A6J74_07655	COG0295	cytidine deaminase activity
A6J74_07660	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6J74_07665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J74_07675	COG2390	Transcriptional regulator
A6J74_07680	COG1309	transcriptional regulator
A6J74_07685	COG1266	CAAX protease self-immunity
A6J74_07715	COG0531	amino acid
A6J74_07720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6J74_07735	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J74_07755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_07770	COG4166	transmembrane transport
A6J74_07790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J74_07800	COG3384	dioxygenase
A6J74_07805	COG2814	Major facilitator Superfamily
A6J74_07830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J74_07850	COG0028	Belongs to the TPP enzyme family
A6J74_07855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J74_07865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J74_07895	COG2323	membrane
A6J74_07900	COG5566	PFAM Mor transcription activator
A6J74_07910	COG0733	neurotransmitter:sodium symporter activity
A6J74_07915	COG2244	polysaccharide biosynthetic process
A6J74_07930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6J74_07935	COG2223	nitrite transmembrane transporter activity
A6J74_07940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J74_07950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J74_07955	COG0477	Major facilitator Superfamily
A6J74_07965	COG1695	Transcriptional regulator
A6J74_08020	COG3620	sequence-specific DNA binding
A6J74_08040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J74_08050	COG1846	Transcriptional regulator
A6J74_08055	COG0784	Response regulator, receiver
A6J74_08060	COG4191	Histidine kinase
A6J74_08065	COG0281	malic enzyme
A6J74_08070	COG1027	Aspartate ammonia-lyase
A6J74_08080	COG0528	UMP kinase activity
A6J74_08085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J74_08100	COG1131	(ABC) transporter
A6J74_08140	COG2733	membrane
A6J74_08160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J74_08165	COG0785	Cytochrome C biogenesis protein
A6J74_08185	COG3340	Belongs to the peptidase S51 family
A6J74_08190	COG0534	Mate efflux family protein
A6J74_08215	COG4221	oxidoreductase activity
A6J74_08220	COG0789	Transcriptional regulator
A6J74_08225	COG1757	Na H antiporter
A6J74_08230	COG1216	Glycosyl transferase, family 2
A6J74_08230	COG0438	transferase activity, transferring glycosyl groups
A6J74_08235	COG0523	cobalamin synthesis protein
A6J74_08245	COG0697	spore germination
A6J74_08250	COG1802	Transcriptional regulator
A6J74_08280	COG0367	asparagine synthase
A6J74_08290	COG1846	Transcriptional regulator
A6J74_08310	COG0406	alpha-ribazole phosphatase activity
A6J74_08345	COG1234	tRNA 3'-trailer cleavage
A6J74_08350	COG1177	transmembrane transport
A6J74_08355	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J74_08360	COG3842	ATPase activity
A6J74_08375	COG2814	Major facilitator Superfamily
A6J74_08390	COG2329	Antibiotic biosynthesis monooxygenase
A6J74_08430	COG4787	bacterial-type flagellum-dependent cell motility
A6J74_08435	COG1419	protein localization to endoplasmic reticulum
A6J74_08440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J74_08445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J74_08455	COG1987	bacterial-type flagellum assembly
A6J74_08460	COG1338	Plays a role in the flagellum-specific transport system
A6J74_08470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J74_08470	COG1776	CheC inhibitor of MCP methylation
A6J74_08475	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J74_08485	COG0741	lytic transglycosylase activity
A6J74_08490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J74_08490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J74_08495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J74_08505	COG0784	Response regulator, receiver
A6J74_08505	COG0835	chemotaxis
A6J74_08520	COG1749	Flagellar hook protein flgE
A6J74_08540	COG1157	protein secretion by the type III secretion system
A6J74_08550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J74_08555	COG1766	The M ring may be actively involved in energy transduction
A6J74_08560	COG1677	Flagellar hook-basal body complex protein FliE
A6J74_08565	COG1558	bacterial-type flagellum-dependent cell motility
A6J74_08570	COG1815	bacterial-type flagellum-dependent cell motility
A6J74_08585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6J74_08590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J74_08595	COG1256	bacterial-type flagellum assembly
A6J74_08615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J74_08630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J74_08630	COG1776	CheC inhibitor of MCP methylation
A6J74_08635	COG0643	Histidine kinase
A6J74_08635	COG2198	Histidine kinase
A6J74_08640	COG2201	protein-glutamate methylesterase activity
A6J74_08645	COG1360	Flagellar Motor Protein
A6J74_08650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6J74_08660	COG1923	regulation of RNA biosynthetic process
A6J74_08680	COG2814	Major facilitator Superfamily
A6J74_08710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6J74_08715	COG2323	membrane
A6J74_08725	COG0789	Transcriptional regulator
A6J74_08725	COG4978	Transcriptional regulator
A6J74_08730	COG0475	glutathione-regulated potassium exporter activity
A6J74_08740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J74_08745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J74_08750	COG3162	membrane
A6J74_08765	COG1280	lysine exporter protein (LysE YggA)
A6J74_08770	COG3403	YqcI/YcgG family
A6J74_08805	COG0328	RNA-DNA hybrid ribonuclease activity
A6J74_08825	COG0454	-acetyltransferase
A6J74_08840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J74_08855	COG0754	glutathionylspermidine amidase activity
A6J74_08900	COG0456	acetyltransferase
A6J74_08910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A6J74_08920	COG2311	Membrane
A6J74_08925	COG2233	PERMEase
A6J74_08935	COG0024	Methionine aminopeptidase
A6J74_08940	COG3173	Aminoglycoside phosphotransferase
A6J74_08950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6J74_08955	COG1199	ATP-dependent helicase activity
A6J74_08965	COG0116	Belongs to the methyltransferase superfamily
A6J74_09025	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J74_09025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J74_09035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J74_09040	COG3935	DnaD domain protein
A6J74_09060	COG1199	ATP-dependent helicase activity
A6J74_09060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J74_09100	COG0438	transferase activity, transferring glycosyl groups
A6J74_09105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6J74_09120	COG1694	Mazg nucleotide pyrophosphohydrolase
A6J74_09125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_09135	COG2738	Putative neutral zinc metallopeptidase
A6J74_09150	COG4347	Protein of unknown function (DUF1405)
A6J74_09160	COG2010	Cytochrome c
A6J74_09160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6J74_09165	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6J74_09185	COG0457	Tetratricopeptide repeat
A6J74_09210	COG0142	geranyltranstransferase activity
A6J74_09220	COG0142	geranyltranstransferase activity
A6J74_09235	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A6J74_09310	COG0492	ferredoxin-NADP+ reductase activity
A6J74_09330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J74_09335	COG4862	establishment of competence for transformation
A6J74_09340	COG0789	Transcriptional regulator
A6J74_09345	COG1408	metallophosphoesterase
A6J74_09355	COG1266	CAAX protease self-immunity
A6J74_09360	COG0514	ATP-dependent DNA helicase (RecQ)
A6J74_09365	COG4955	Helix-turn-helix domain
A6J74_09370	COG1141	Ferredoxin
A6J74_09375	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6J74_09385	COG4942	peptidase
A6J74_09390	COG2096	Adenosyltransferase
A6J74_09395	COG5002	protein histidine kinase activity
A6J74_09400	COG0745	RESPONSE REGULATOR receiver
A6J74_09405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J74_09410	COG1333	cytochrome c biogenesis protein
A6J74_09420	COG1187	pseudouridine synthase activity
A6J74_09425	COG0700	Nucleoside recognition
A6J74_09430	COG2715	membrane protein required for spore maturation
A6J74_09435	COG1686	Belongs to the peptidase S11 family
A6J74_09440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J74_09455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6J74_09455	COG0392	lysyltransferase activity
A6J74_09470	COG5002	protein histidine kinase activity
A6J74_09475	COG0582	viral genome integration into host DNA
A6J74_09485	COG1801	Protein of unknown function DUF72
A6J74_09490	COG3852	Histidine kinase
A6J74_09505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J74_09510	COG1392	Phosphate transport regulator
A6J74_09515	COG0306	phosphate transporter
A6J74_09520	COG0730	response to heat
A6J74_09560	COG2226	methyltransferase
A6J74_09570	COG1114	Component of the transport system for branched-chain amino acids
A6J74_09580	COG2197	response regulator
A6J74_09585	COG4585	Histidine kinase
A6J74_09590	COG4758	membrane
A6J74_09605	COG1757	Na H antiporter
A6J74_09625	COG0733	neurotransmitter:sodium symporter activity
A6J74_09635	COG1648	precorrin-2 dehydrogenase activity
A6J74_09655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6J74_09660	COG0529	Catalyzes the synthesis of activated sulfate
A6J74_09680	COG0019	diaminopimelate decarboxylase activity
A6J74_09690	COG1368	sulfuric ester hydrolase activity
A6J74_09695	COG1183	phosphatidylcholine synthase activity
A6J74_09700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J74_09710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6J74_09785	COG0440	acetolactate synthase activity
A6J74_09790	COG0028	Belongs to the TPP enzyme family
A6J74_09795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J74_09825	COG3874	Sporulation protein YtfJ
A6J74_09830	COG4709	membrane
A6J74_09835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J74_09840	COG1301	dicarboxylic acid transport
A6J74_09850	COG1846	Transcriptional regulator
A6J74_09870	COG1968	undecaprenyl-diphosphatase activity
A6J74_09875	COG0534	Mate efflux family protein
A6J74_09915	COG0716	FMN binding
A6J74_09940	COG1696	Membrane protein involved in D-alanine export
A6J74_09950	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6J74_09955	COG2070	2-Nitropropane dioxygenase
A6J74_09960	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J74_09970	COG1335	isochorismatase
A6J74_09980	COG1522	sequence-specific DNA binding
A6J74_09990	COG1266	CAAX protease self-immunity
A6J74_09995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A6J74_10000	COG1131	(ABC) transporter
A6J74_10010	COG1131	(ABC) transporter
A6J74_10015	COG1725	Transcriptional regulator
A6J74_10030	COG2204	response regulator
A6J74_10045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J74_10050	COG0531	amino acid
A6J74_10055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J74_10070	COG1780	Probably involved in ribonucleotide reductase function
A6J74_10090	COG0456	acetyltransferase
A6J74_10105	COG4873	Protein conserved in bacteria
A6J74_10120	COG0720	synthase
A6J74_10130	COG5002	protein histidine kinase activity
A6J74_10140	COG2318	DinB family
A6J74_10150	COG1846	Transcriptional regulator
A6J74_10155	COG3852	Histidine kinase
A6J74_10170	COG2861	carbohydrate metabolic process
A6J74_10180	COG0235	Class ii aldolase
A6J74_10200	COG1349	DNA-binding transcription factor activity
A6J74_10225	COG3842	ATPase activity
A6J74_10230	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J74_10250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J74_10260	COG3243	poly(R)-hydroxyalkanoic acid synthase
A6J74_10265	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_10285	COG2030	dehydratase
A6J74_10295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J74_10300	COG0861	Integral membrane protein TerC family
A6J74_10305	COG2116	formate transmembrane transporter activity
A6J74_10315	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A6J74_10335	COG2186	Transcriptional regulator
A6J74_10340	COG5002	protein histidine kinase activity
A6J74_10345	COG0745	RESPONSE REGULATOR receiver
A6J74_10355	COG3835	regulator
A6J74_10360	COG0277	FAD linked oxidase domain protein
A6J74_10365	COG0247	lactate metabolic process
A6J74_10370	COG2340	Cysteine-rich secretory protein family
A6J74_10380	COG0564	pseudouridine synthase activity
A6J74_10390	COG2409	Drug exporters of the RND superfamily
A6J74_10400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6J74_10405	COG1177	transmembrane transport
A6J74_10410	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J74_10420	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_10455	COG0681	Belongs to the peptidase S26 family
A6J74_10460	COG1686	Belongs to the peptidase S11 family
A6J74_10505	COG1668	transmembrane transport
A6J74_10510	COG4152	abc transporter atp-binding protein
A6J74_10550	COG1476	TRANSCRIPTIONal
A6J74_10560	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J74_10580	COG2226	methyltransferase
A6J74_10655	COG5634	Uncharacterized conserved protein (DUF2278)
A6J74_10660	COG1620	l-lactate permease
A6J74_10695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J74_10695	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J74_10710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J74_10715	COG5492	domain, Protein
A6J74_10725	COG0697	spore germination
A6J74_10730	COG2382	esterase
A6J74_10740	COG2153	protein acetylation
A6J74_10785	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J74_10800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6J74_10820	COG0463	Glycosyl transferase, family 2
A6J74_10820	COG0457	Tetratricopeptide repeat
A6J74_10840	COG1216	Glycosyl transferase, family 2
A6J74_10845	COG0772	Belongs to the SEDS family
A6J74_10870	COG0564	pseudouridine synthase activity
A6J74_10880	COG2357	RelA SpoT domain protein
A6J74_10890	COG4116	CYTH
A6J74_10895	COG2346	COG2346, Truncated hemoglobins
A6J74_10910	COG1164	Oligoendopeptidase f
A6J74_10920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J74_10930	COG0861	Integral membrane protein TerC family
A6J74_10935	COG1393	Belongs to the ArsC family
A6J74_10950	COG4166	transmembrane transport
A6J74_10955	COG0534	Mate efflux family protein
A6J74_10960	COG4608	Belongs to the ABC transporter superfamily
A6J74_10965	COG0444	Belongs to the ABC transporter superfamily
A6J74_10970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J74_10975	COG0601	transmembrane transport
A6J74_10980	COG4166	transmembrane transport
A6J74_10995	COG0180	Tryptophanyl-tRNA synthetase
A6J74_11010	COG5504	Zn-dependent protease
A6J74_11015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J74_11020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J74_11035	COG2267	carboxylic ester hydrolase activity
A6J74_11060	COG0561	phosphatase activity
A6J74_11075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_11100	COG2996	Protein conserved in bacteria
A6J74_11125	COG0004	ammonium transporteR
A6J74_11130	COG0753	catalase activity
A6J74_11140	COG0367	asparagine synthase
A6J74_11165	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J74_11225	COG0398	Pfam SNARE associated Golgi protein
A6J74_11235	COG4903	ComK protein
A6J74_11245	COG1278	Cold shock
A6J74_11265	COG2224	Isocitrate lyase
A6J74_11270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6J74_11275	COG0697	spore germination
A6J74_11280	COG0840	transmembrane signaling receptor activity
A6J74_11285	COG0501	Belongs to the peptidase M48B family
A6J74_11320	COG0745	RESPONSE REGULATOR receiver
A6J74_11325	COG2205	protein histidine kinase activity
A6J74_11340	COG2207	Transcriptional regulator
A6J74_11340	COG3708	Transcriptional regulator
A6J74_11345	COG1595	DNA-templated transcription, initiation
A6J74_11355	COG1078	dGTPase activity
A6J74_11365	COG1408	metallophosphoesterase
A6J74_11385	COG0318	PFAM AMP-dependent synthetase and ligase
A6J74_11395	COG0095	Lipoate-protein ligase
A6J74_11400	COG1234	tRNA 3'-trailer cleavage
A6J74_11410	COG1609	Transcriptional regulator
A6J74_11450	COG1511	domain protein
A6J74_11455	COG1309	transcriptional regulator
A6J74_11500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J74_11505	COG2329	Antibiotic biosynthesis monooxygenase
A6J74_11510	COG3428	Bacterial PH domain
A6J74_11515	COG3402	PFAM membrane-flanked domain
A6J74_11560	COG3428	Bacterial PH domain
A6J74_11565	COG3402	PFAM membrane-flanked domain
A6J74_11575	COG1309	transcriptional regulator
A6J74_11590	COG4473	ABC transporter
A6J74_11595	COG1131	(ABC) transporter
A6J74_11605	COG0537	adenosine 5'-monophosphoramidase activity
A6J74_11635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J74_11640	COG3973	AAA domain
A6J74_11655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J74_11665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J74_11670	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A6J74_11675	COG3620	sequence-specific DNA binding
A6J74_11695	COG0457	Tetratricopeptide repeat
A6J74_11700	COG0346	lactoylglutathione lyase activity
A6J74_11705	COG0346	lactoylglutathione lyase activity
A6J74_11715	COG0714	Associated with various cellular activities
A6J74_11735	COG4717	serine-type aminopeptidase activity
A6J74_11740	COG0420	3'-5' exonuclease activity
A6J74_11775	COG2186	Transcriptional regulator
A6J74_11780	COG2807	transmembrane transport
A6J74_11815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J74_11820	COG2208	phosphoserine phosphatase activity
A6J74_11830	COG1191	sigma factor activity
A6J74_11855	COG3237	CsbD-like
A6J74_11895	COG3850	Histidine kinase
A6J74_11895	COG5002	protein histidine kinase activity
A6J74_11900	COG0745	RESPONSE REGULATOR receiver
A6J74_11915	COG1959	2 iron, 2 sulfur cluster binding
A6J74_11925	COG2376	Dihydroxyacetone kinase
A6J74_11935	COG2376	Dihydroxyacetone kinase
A6J74_11950	COG0640	Transcriptional regulator
A6J74_11955	COG2814	Major facilitator Superfamily
A6J74_11985	COG1183	phosphatidylcholine synthase activity
A6J74_11995	COG2723	6-phospho-beta-galactosidase activity
A6J74_12000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J74_12000	COG2190	(PTS) system
A6J74_12000	COG1263	PTS System
A6J74_12005	COG3711	transcriptional antiterminator
A6J74_12015	COG5632	N-Acetylmuramoyl-L-alanine amidase
A6J74_12015	COG3409	Peptidoglycan-binding domain 1 protein
A6J74_12055	COG0477	Major facilitator Superfamily
A6J74_12075	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_12080	COG0305	Participates in initiation and elongation during chromosome replication
A6J74_12130	COG0582	viral genome integration into host DNA
A6J74_12140	COG3181	Tripartite tricarboxylate transporter family receptor
A6J74_12145	COG4565	transcriptional regulatory protein
A6J74_12150	COG3290	protein histidine kinase activity
A6J74_12155	COG0477	Major facilitator Superfamily
A6J74_12205	COG0582	viral genome integration into host DNA
A6J74_12280	COG0457	Tetratricopeptide repeat
A6J74_12300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_12310	COG4608	Belongs to the ABC transporter superfamily
A6J74_12315	COG0444	Belongs to the ABC transporter superfamily
A6J74_12320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J74_12325	COG0601	transmembrane transport
A6J74_12350	COG0579	oxidoreductase
A6J74_12380	COG1363	Peptidase, m42
A6J74_12405	COG1024	Enoyl-CoA hydratase
A6J74_12415	COG0659	secondary active sulfate transmembrane transporter activity
A6J74_12430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J74_12440	COG0561	phosphatase activity
A6J74_12450	COG3527	Alpha-acetolactate decarboxylase
A6J74_12455	COG0028	Belongs to the TPP enzyme family
A6J74_12475	COG0189	ligase activity
A6J74_12490	COG1126	abc transporter atp-binding protein
A6J74_12495	COG0765	amino acid transport
A6J74_12500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J74_12510	COG1132	(ABC) transporter
A6J74_12515	COG1132	(ABC) transporter
A6J74_12530	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_12535	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J74_12540	COG0531	amino acid
A6J74_12550	COG0693	protein deglycase activity
A6J74_12560	COG2211	Major facilitator Superfamily
A6J74_12565	COG4533	DNA binding
A6J74_12575	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J74_12585	COG1733	regulation of RNA biosynthetic process
A6J74_12590	COG2814	Major facilitator Superfamily
A6J74_12595	COG1309	transcriptional regulator
A6J74_12600	COG2076	Multidrug Resistance protein
A6J74_12605	COG2076	Multidrug Resistance protein
A6J74_12635	COG1522	sequence-specific DNA binding
A6J74_12655	COG2259	Doxx family
A6J74_12665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J74_12665	COG1263	PTS System
A6J74_12675	COG1737	Transcriptional regulator
A6J74_12685	COG0475	glutathione-regulated potassium exporter activity
A6J74_12690	COG0531	amino acid
A6J74_12725	COG0586	Pfam SNARE associated Golgi protein
A6J74_12760	COG3546	catalase activity
A6J74_12765	COG1114	Component of the transport system for branched-chain amino acids
A6J74_12780	COG5522	Integral membrane protein (intg_mem_TP0381)
A6J74_12790	COG1136	(ABC) transporter
A6J74_12795	COG0577	efflux transmembrane transporter activity
A6J74_12800	COG1388	LysM domain
A6J74_12800	COG3584	3D domain protein
A6J74_12820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J74_12825	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J74_12830	COG3711	transcriptional antiterminator
A6J74_12830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J74_12845	COG2814	Major facilitator Superfamily
A6J74_12850	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6J74_12855	COG0604	alcohol dehydrogenase
A6J74_12860	COG1316	TRANSCRIPTIONal
A6J74_12870	COG0730	response to heat
A6J74_12875	COG2210	Belongs to the sulfur carrier protein TusA family
A6J74_12880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J74_12885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J74_12885	COG0425	Belongs to the sulfur carrier protein TusA family
A6J74_12890	COG0425	Belongs to the sulfur carrier protein TusA family
A6J74_12895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J74_12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_12900	COG0425	Belongs to the sulfur carrier protein TusA family
A6J74_12900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J74_12905	COG1937	Protein conserved in bacteria
A6J74_12910	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J74_12925	COG2719	SpoVR family
A6J74_12930	COG0778	Nitroreductase
A6J74_12990	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_12995	COG2252	PERMEase
A6J74_13005	COG1129	ABC transporter
A6J74_13010	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J74_13025	COG1846	Transcriptional regulator
A6J74_13030	COG2814	Major facilitator Superfamily
A6J74_13035	COG2205	protein histidine kinase activity
A6J74_13080	COG0351	phosphomethylpyrimidine kinase
A6J74_13085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J74_13095	COG2104	thiamine diphosphate biosynthetic process
A6J74_13100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J74_13105	COG0352	thiamine-phosphate diphosphorylase activity
A6J74_13110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J74_13115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J74_13120	COG1116	anion transmembrane transporter activity
A6J74_13125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6J74_13150	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A6J74_13270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J74_13280	COG0581	inorganic phosphate transmembrane transporter activity
A6J74_13285	COG0573	inorganic phosphate transmembrane transporter activity
A6J74_13290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J74_13295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A6J74_13295	COG1918	ferrous iron import across plasma membrane
A6J74_13300	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A6J74_13305	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A6J74_13320	COG0531	amino acid
A6J74_13325	COG0697	spore germination
A6J74_13330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J74_13345	COG4990	cell redox homeostasis
A6J74_13350	COG0833	amino acid
A6J74_13355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6J74_13360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6J74_13365	COG1845	cytochrome c oxidase, subunit III
A6J74_13375	COG0569	domain protein
A6J74_13375	COG0475	glutathione-regulated potassium exporter activity
A6J74_13400	COG2252	PERMEase
A6J74_13405	COG1113	amino acid transport
A6J74_13420	COG1114	Component of the transport system for branched-chain amino acids
A6J74_13425	COG3104	oligopeptide transport
A6J74_13445	COG1476	TRANSCRIPTIONal
A6J74_13450	COG3584	3D domain protein
A6J74_13450	COG1388	LysM domain
A6J74_13455	COG0840	transmembrane signaling receptor activity
A6J74_13505	COG1063	alcohol dehydrogenase
A6J74_13530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J74_13535	COG1879	ABC-type sugar transport system periplasmic component
A6J74_13540	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J74_13555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J74_13560	COG1609	Transcriptional regulator
A6J74_13565	COG0477	Major facilitator Superfamily
A6J74_13570	COG1846	Transcriptional regulator
A6J74_13575	COG2271	Major facilitator Superfamily
A6J74_13590	COG0659	secondary active sulfate transmembrane transporter activity
A6J74_13605	COG5002	protein histidine kinase activity
A6J74_13610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J74_13615	COG2378	regulation of single-species biofilm formation
A6J74_13625	COG1595	DNA-templated transcription, initiation
A6J74_13640	COG0833	amino acid
A6J74_13645	COG0765	amino acid transport
A6J74_13650	COG0765	amino acid transport
A6J74_13655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J74_13660	COG1126	abc transporter atp-binding protein
A6J74_13670	COG1115	amino acid carrier protein
A6J74_13675	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6J74_13685	COG1404	Belongs to the peptidase S8 family
A6J74_13690	COG2197	response regulator
A6J74_13695	COG4585	Histidine kinase
A6J74_13700	COG0697	spore germination
A6J74_13715	COG0366	Alpha amylase catalytic
A6J74_13720	COG1263	PTS System
A6J74_13720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J74_13725	COG2188	Transcriptional regulator
A6J74_13730	COG0531	amino acid
A6J74_13750	COG0714	Associated with various cellular activities
A6J74_13755	COG4548	von Willebrand factor, type A
A6J74_13765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J74_13775	COG2226	methyltransferase
A6J74_13785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_13790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_13795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J74_13800	COG3104	oligopeptide transport
A6J74_13815	COG1620	l-lactate permease
A6J74_13820	COG1027	Aspartate ammonia-lyase
A6J74_13825	COG1253	flavin adenine dinucleotide binding
A6J74_13830	COG0346	lactoylglutathione lyase activity
A6J74_13835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J74_13845	COG1316	TRANSCRIPTIONal
A6J74_13850	COG2720	vancomycin resistance protein
A6J74_13870	COG3227	Zinc metalloprotease (Elastase)
A6J74_13880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J74_13885	COG2217	Heavy metal translocating P-type atpase
A6J74_13890	COG0640	Transcriptional regulator
A6J74_13900	COG0531	amino acid
A6J74_13915	COG2427	Protein of unknown function (DUF1641)
A6J74_13920	COG3383	formate dehydrogenase (NAD+) activity
A6J74_13925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J74_13930	COG0454	-acetyltransferase
A6J74_13930	COG0456	acetyltransferase
A6J74_13940	COG0745	RESPONSE REGULATOR receiver
A6J74_13945	COG5002	protein histidine kinase activity
A6J74_13955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_13960	COG0697	spore germination
A6J74_13970	COG0281	malic enzyme
A6J74_13975	COG3493	citrate carrier protein
A6J74_13980	COG4565	transcriptional regulatory protein
A6J74_13985	COG3290	protein histidine kinase activity
A6J74_13995	COG4990	cell redox homeostasis
A6J74_14005	COG5002	protein histidine kinase activity
A6J74_14010	COG0745	RESPONSE REGULATOR receiver
A6J74_14015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6J74_14025	COG0395	ABC-type sugar transport system, permease component
A6J74_14030	COG1175	transmembrane transport
A6J74_14035	COG3842	ATPase activity
A6J74_14040	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A6J74_14065	COG2851	Citrate transporter
A6J74_14070	COG4565	transcriptional regulatory protein
A6J74_14075	COG3290	protein histidine kinase activity
A6J74_14085	COG2268	Band 7 protein
A6J74_14090	COG1585	Membrane protein implicated in regulation of membrane protease activity
A6J74_14115	COG2766	serine protein kinase
A6J74_14125	COG1716	ATPase activity
A6J74_14125	COG5001	Diguanylate cyclase
A6J74_14130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6J74_14155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6J74_14280	COG0735	belongs to the Fur family
A6J74_14285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J74_14305	COG4555	ABC transporter
A6J74_14315	COG0070	glutamate synthase
A6J74_14315	COG0069	glutamate synthase activity
A6J74_14315	COG0067	glutamate synthase
A6J74_14320	COG4129	membrane
A6J74_14325	COG1132	(ABC) transporter
A6J74_14350	COG1194	a g-specific adenine glycosylase
A6J74_14355	COG1988	membrane-bound metal-dependent
A6J74_14385	COG1090	epimerase
A6J74_14390	COG1228	amidohydrolase
A6J74_14410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J74_14415	COG1882	Formate acetyltransferase
A6J74_14425	COG0463	Glycosyl transferase, family 2
A6J74_14430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J74_14430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J74_14440	COG0463	Glycosyl transferase, family 2
A6J74_14460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J74_14465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J74_14465	COG1263	PTS System
A6J74_14475	COG2066	Belongs to the glutaminase family
A6J74_14500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J74_14505	COG0833	amino acid
A6J74_14515	COG3829	transcription factor binding
A6J74_14535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6J74_14555	COG0535	radical SAM domain protein
A6J74_14565	COG0387	Pfam Sodium calcium exchanger
A6J74_14570	COG3871	stress protein (general stress protein 26)
A6J74_14585	COG0586	Pfam SNARE associated Golgi protein
A6J74_14605	COG0697	spore germination
A6J74_14610	COG2217	Heavy metal translocating P-type atpase
A6J74_14620	COG1295	ribonuclease BN
A6J74_14630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J74_14645	COG3853	Toxic anion resistance protein (TelA)
A6J74_14655	COG0861	Integral membrane protein TerC family
A6J74_14660	COG2310	stress, protein
A6J74_14665	COG2310	stress, protein
A6J74_14670	COG2310	stress, protein
A6J74_14680	COG4193	domain, Protein
A6J74_14680	COG4193	domain, Protein
A6J74_14705	COG2270	Major facilitator Superfamily
A6J74_14755	COG1116	anion transmembrane transporter activity
A6J74_14765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J74_14785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J74_14790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J74_14820	COG2190	(PTS) system
A6J74_14820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J74_14820	COG1263	PTS System
A6J74_14825	COG0366	Alpha amylase catalytic
A6J74_14830	COG0277	FAD linked oxidase domain protein
A6J74_14845	COG0549	Belongs to the carbamate kinase family
A6J74_14870	COG0840	transmembrane signaling receptor activity
A6J74_14880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J74_14885	COG0765	amino acid transport
A6J74_14895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J74_14895	COG0723	plastoquinol--plastocyanin reductase activity
A6J74_14900	COG2814	Major facilitator Superfamily
A6J74_14905	COG3541	Predicted nucleotidyltransferase
A6J74_14925	COG5002	protein histidine kinase activity
A6J74_14950	COG0166	Belongs to the GPI family
A6J74_14975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J74_14980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_14985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_14990	COG0235	Class ii aldolase
A6J74_15000	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A6J74_15005	COG0450	alkyl hydroperoxide reductase
A6J74_15020	COG1473	amidohydrolase
A6J74_15050	COG4807	Protein conserved in bacteria
A6J74_15060	COG5002	protein histidine kinase activity
A6J74_15065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J74_15075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J74_15090	COG2309	aminopeptidase activity
A6J74_15100	COG2076	Multidrug Resistance protein
A6J74_15105	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_15115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6J74_15120	COG0546	phosphoglycolate phosphatase activity
A6J74_15125	COG1597	lipid kinase activity
A6J74_15145	COG4682	membrane
A6J74_15150	COG1846	Transcriptional regulator
A6J74_15155	COG0003	Pfam Anion-transporting ATPase
A6J74_15170	COG1464	Belongs to the NlpA lipoprotein family
A6J74_15175	COG2011	ABC-type metal ion transport system permease component
A6J74_15185	COG1335	isochorismatase
A6J74_15200	COG4851	CamS sex pheromone cAM373 precursor
A6J74_15210	COG0210	DNA helicase
A6J74_15235	COG0151	Belongs to the GarS family
A6J74_15245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J74_15255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J74_15270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J74_15280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J74_15285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J74_15290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J74_15315	COG0745	RESPONSE REGULATOR receiver
A6J74_15320	COG2205	protein histidine kinase activity
A6J74_15370	COG0697	spore germination
A6J74_15390	COG1215	transferase activity, transferring glycosyl groups
A6J74_15440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A6J74_15465	COG5002	protein histidine kinase activity
A6J74_15475	COG2252	PERMEase
A6J74_15500	COG1266	CAAX protease self-immunity
A6J74_15515	COG0488	(ABC) transporter
A6J74_15525	COG0456	acetyltransferase
A6J74_15530	COG1214	PFAM Peptidase M22, glycoprotease
A6J74_15535	COG0802	atpase or kinase
A6J74_15635	COG2183	response to ionizing radiation
A6J74_15640	COG2337	Toxic component of a toxin-antitoxin (TA) module
A6J74_15645	COG0864	Transcriptional regulator
A6J74_15650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J74_15655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6J74_15665	COG0705	Rhomboid family
A6J74_15670	COG4294	response to UV
A6J74_15680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J74_15690	COG2814	Major facilitator Superfamily
A6J74_15695	COG0531	amino acid
A6J74_15705	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J74_15710	COG3185	4-Hydroxyphenylpyruvate dioxygenase
A6J74_15740	COG0561	phosphatase activity
A6J74_15745	COG4608	Belongs to the ABC transporter superfamily
A6J74_15750	COG0444	Belongs to the ABC transporter superfamily
A6J74_15760	COG0601	transmembrane transport
A6J74_15765	COG0747	negative chemotaxis
A6J74_15775	COG0488	(ABC) transporter
A6J74_15800	COG5298	Protein conserved in bacteria
A6J74_15820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_15830	COG1609	Transcriptional regulator
A6J74_15845	COG0204	Acyl-transferase
A6J74_15865	COG0697	spore germination
A6J74_15885	COG1910	domain protein
A6J74_15890	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6J74_15895	COG4149	molybdate abc transporter
A6J74_15920	COG0656	L-ascorbic acid biosynthetic process
A6J74_15925	COG4166	transmembrane transport
A6J74_15930	COG4166	transmembrane transport
A6J74_15945	COG2207	Transcriptional regulator
A6J74_15955	COG4166	transmembrane transport
A6J74_15960	COG4608	Belongs to the ABC transporter superfamily
A6J74_15965	COG0444	Belongs to the ABC transporter superfamily
A6J74_15970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J74_15975	COG0601	transmembrane transport
A6J74_15990	COG2814	Major facilitator Superfamily
A6J74_16000	COG2271	Major facilitator Superfamily
A6J74_16005	COG0277	FAD linked oxidase domain protein
A6J74_16020	COG1464	Belongs to the NlpA lipoprotein family
A6J74_16030	COG2011	ABC-type metal ion transport system permease component
A6J74_16035	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_16070	COG4856	YbbR-like protein
A6J74_16075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6J74_16160	COG0726	polysaccharide deacetylase
A6J74_16165	COG2194	sulfuric ester hydrolase activity
A6J74_16175	COG0489	protein tyrosine kinase activity
A6J74_16180	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J74_16200	COG0101	tRNA pseudouridine synthase activity
A6J74_16205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6J74_16210	COG1122	ATPase activity
A6J74_16240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J74_16250	COG0024	Methionine aminopeptidase
A6J74_16260	COG0201	protein transport
A6J74_16285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J74_16390	COG1358	cellular component organization or biogenesis
A6J74_16405	COG2813	Specifically methylates the guanine in position
A6J74_16430	COG0250	Participates in transcription elongation, termination and antitermination
A6J74_16435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J74_16450	COG3688	RNA-binding protein containing a PIN domain
A6J74_16455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J74_16470	COG1045	serine acetyltransferase
A6J74_16490	COG4956	integral membrane protein (PIN domain superfamily)
A6J74_16500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6J74_16505	COG0542	response to heat
A6J74_16515	COG3880	PFAM UvrB UvrC protein
A6J74_16610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J74_16615	COG1396	sequence-specific DNA binding
A6J74_16620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J74_16625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6J74_16630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J74_16635	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J74_16640	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J74_16645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J74_16650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6J74_16665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J74_16680	COG2208	phosphoserine phosphatase activity
A6J74_16695	COG1098	S1 RNA binding domain
A6J74_16715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J74_16720	COG3956	TIGRFAM MazG family protein
A6J74_16725	COG2244	polysaccharide biosynthetic process
A6J74_16730	COG2002	toxin-antitoxin pair type II binding
A6J74_16735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J74_16750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J74_16760	COG2088	sporulation resulting in formation of a cellular spore
A6J74_16765	COG0251	oxidation-reduction process
A6J74_16775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J74_16790	COG4466	Protein conserved in bacteria
A6J74_16810	COG0084	hydrolase, TatD family'
A6J74_16820	COG2002	toxin-antitoxin pair type II binding
A6J74_16825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J74_16835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J74_16845	COG1774	PSP1 C-terminal conserved region
A6J74_16850	COG0470	DNA polymerase III
A6J74_16860	COG1982	Orn Lys Arg decarboxylase major
A6J74_16915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J74_16925	COG0590	tRNA wobble adenosine to inosine editing
A6J74_16935	COG1335	isochorismatase
A6J74_16940	COG1428	Deoxynucleoside kinase
A6J74_16945	COG1428	Deoxynucleoside kinase
A6J74_16975	COG1686	Belongs to the peptidase S11 family
A6J74_16980	COG0516	GMP reductase activity
A6J74_16980	COG0517	IMP dehydrogenase activity
A6J74_17015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J74_17020	COG0187	DNA topoisomerase II activity
A6J74_17030	COG2501	S4 domain
A6J74_17035	COG0592	DNA-directed DNA polymerase activity
A6J74_17055	COG0706	membrane insertase activity
A6J74_17060	COG1847	R3H domain protein
A6J74_17085	COG1192	Involved in chromosome partitioning
A6J74_17090	COG1475	DNA binding
A6J74_17100	COG0668	transmembrane transport
A6J74_17105	COG4481	Protein conserved in bacteria
A6J74_17110	COG0012	GTP binding
A6J74_17120	COG0629	single-stranded DNA binding
A6J74_17130	COG4241	membrane
A6J74_17135	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A6J74_17145	COG0305	Participates in initiation and elongation during chromosome replication
A6J74_17175	COG0745	RESPONSE REGULATOR receiver
A6J74_17180	COG5002	protein histidine kinase activity
A6J74_17190	COG4853	Protein conserved in bacteria
A6J74_17195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J74_17200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J74_17220	COG1164	Oligoendopeptidase f
A6J74_17245	COG1272	protein, Hemolysin III
A6J74_17250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J74_17285	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A6J74_17290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J74_17295	COG2814	Major facilitator Superfamily
A6J74_17300	COG3275	phosphorelay sensor kinase activity
A6J74_17320	COG0628	permease
A6J74_17325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J74_17325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J74_17330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J74_17335	COG1309	transcriptional regulator
A6J74_17340	COG0463	Glycosyl transferase, family 2
A6J74_17360	COG0488	(ABC) transporter
A6J74_17365	COG1309	transcriptional regulator
A6J74_17375	COG1215	transferase activity, transferring glycosyl groups
A6J74_17385	COG1607	acyl-coa hydrolase
A6J74_17395	COG0840	transmembrane signaling receptor activity
A6J74_17410	COG0438	transferase activity, transferring glycosyl groups
A6J74_17425	COG0477	Major facilitator Superfamily
A6J74_17430	COG3279	Response regulator of the LytR AlgR family
A6J74_17435	COG1966	Carbon starvation protein
A6J74_17440	COG2879	small protein
A6J74_17445	COG3706	GGDEF domain
A6J74_17450	COG0351	phosphomethylpyrimidine kinase
A6J74_17455	COG2203	Gaf domain
A6J74_17455	COG4585	Histidine kinase
A6J74_17460	COG2197	response regulator
A6J74_17470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J74_17475	COG1011	Hydrolase
A6J74_17495	COG0460	homoserine dehydrogenase
A6J74_17505	COG1609	Transcriptional regulator
A6J74_17510	COG2755	lipolytic protein G-D-S-L family
A6J74_17515	COG1131	(ABC) transporter
A6J74_17520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A6J74_17530	COG2814	Major facilitator Superfamily
A6J74_17535	COG0561	phosphatase activity
A6J74_17540	COG2233	PERMEase
A6J74_17545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J74_17555	COG2363	Small membrane protein
A6J74_17565	COG3773	Cell wall hydrolase
A6J74_17585	COG0280	phosphate acetyltransferase
A6J74_17605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_17610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_17615	COG1120	ATPase activity
A6J74_17620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J74_17625	COG1078	dGTPase activity
A6J74_17635	COG1994	Peptidase M50
A6J74_17645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J74_17650	COG0584	glycerophosphoryl diester phosphodiesterase
A6J74_17655	COG0789	Transcriptional regulator
A6J74_17660	COG2814	Major facilitator Superfamily
A6J74_17695	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J74_17700	COG4506	Protein conserved in bacteria
A6J74_17715	COG2234	aminopeptidase activity
A6J74_17720	COG0024	Methionine aminopeptidase
A6J74_17725	COG1131	(ABC) transporter
A6J74_17730	COG0842	Transport permease protein
A6J74_17735	COG4585	Histidine kinase
A6J74_17740	COG2197	response regulator
A6J74_17745	COG3227	Zinc metalloprotease (Elastase)
A6J74_17760	COG3300	MHYT domain
A6J74_17760	COG5001	Diguanylate cyclase
A6J74_17770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J74_17775	COG0247	lactate metabolic process
A6J74_17775	COG2181	nitrate reductase activity
A6J74_17780	COG0183	Belongs to the thiolase family
A6J74_17785	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J74_17790	COG1960	acyl-CoA dehydrogenase activity
A6J74_17795	COG1960	acyl-CoA dehydrogenase activity
A6J74_17815	COG4821	SIS domain
A6J74_17840	COG1494	fructose-1,6-bisphosphatase
A6J74_17845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6J74_17880	COG0009	L-threonylcarbamoyladenylate synthase
A6J74_17895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6J74_17900	COG2259	Doxx family
A6J74_17905	COG2190	(PTS) system
A6J74_17915	COG0698	ribose 5-phosphate isomerase
A6J74_17950	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J74_18020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J74_18040	COG0839	Belongs to the complex I subunit 6 family
A6J74_18050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J74_18055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J74_18060	COG1007	ATP synthesis coupled electron transport
A6J74_18065	COG4836	Membrane
A6J74_18075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J74_18080	COG2385	sporulation resulting in formation of a cellular spore
A6J74_18085	COG3279	Response regulator of the LytR AlgR family
A6J74_18100	COG0739	heme binding
A6J74_18110	COG1609	Transcriptional regulator
A6J74_18125	COG0489	protein tyrosine kinase activity
A6J74_18130	COG3944	biosynthesis protein
A6J74_18135	COG0489	protein tyrosine kinase activity
A6J74_18140	COG4464	protein tyrosine phosphatase activity
A6J74_18145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J74_18150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J74_18205	COG0438	transferase activity, transferring glycosyl groups
A6J74_18210	COG0438	transferase activity, transferring glycosyl groups
A6J74_18220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6J74_18235	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J74_18250	COG3475	LICD family
A6J74_18260	COG0697	spore germination
A6J74_18265	COG4750	Nucleotidyl transferase
A6J74_18270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J74_18275	COG0745	RESPONSE REGULATOR receiver
A6J74_18280	COG5002	protein histidine kinase activity
A6J74_18280	COG3850	Histidine kinase
A6J74_18295	COG2271	Major facilitator Superfamily
A6J74_18305	COG1136	(ABC) transporter
A6J74_18310	COG0577	efflux transmembrane transporter activity
A6J74_18350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J74_18355	COG4715	Zinc finger, swim domain protein
A6J74_18365	COG3584	3D domain protein
A6J74_18365	COG1388	LysM domain
A6J74_18375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6J74_18385	COG1215	transferase activity, transferring glycosyl groups
A6J74_18395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J74_18400	COG1388	LysM domain
A6J74_18400	COG0791	NLP P60 protein
A6J74_18410	COG1368	sulfuric ester hydrolase activity
A6J74_18425	COG2389	metal-binding protein
A6J74_18435	COG1620	l-lactate permease
A6J74_18445	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6J74_18450	COG1294	oxidase, subunit
A6J74_18455	COG1271	oxidase subunit
A6J74_18465	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A6J74_18470	COG0583	DNA-binding transcription factor activity
A6J74_18475	COG1511	domain protein
A6J74_18480	COG0346	lactoylglutathione lyase activity
A6J74_18495	COG1301	dicarboxylic acid transport
A6J74_18500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J74_18510	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J74_18520	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6J74_18520	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6J74_18530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J74_18535	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J74_18540	COG1486	melibiose metabolic process
A6J74_18560	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A6J74_18560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6J74_18570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J74_18575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A6J74_18580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6J74_18585	COG1316	TRANSCRIPTIONal
A6J74_18590	COG1739	Uncharacterized protein family UPF0029
A6J74_18595	COG1307	EDD domain protein, DegV family
A6J74_18605	COG1733	regulation of RNA biosynthetic process
A6J74_18610	COG0791	NLP P60 protein
A6J74_18610	COG1388	LysM domain
A6J74_18615	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6J74_18620	COG1040	competence protein
A6J74_18625	COG1278	Cold shock
A6J74_18630	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6J74_18650	COG2884	Cell division ATP-binding protein ftsE
A6J74_18655	COG2177	Part of the ABC transporter FtsEX involved in
A6J74_18660	COG0793	Belongs to the peptidase S41A family
A6J74_18660	COG3409	Peptidoglycan-binding domain 1 protein
A6J74_18665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J74_18670	COG1132	(ABC) transporter
A6J74_18685	COG0655	NAD(P)H dehydrogenase (quinone) activity
A6J74_18695	COG0583	DNA-binding transcription factor activity
A6J74_18715	COG0789	Transcriptional regulator
A6J74_18725	COG0556	nucleotide-excision repair
A6J74_18730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J74_18740	COG1950	PFAM Membrane protein of
A6J74_18760	COG0110	maltose O-acetyltransferase activity
A6J74_18765	COG0457	Tetratricopeptide repeat
A6J74_18770	COG0492	ferredoxin-NADP+ reductase activity
A6J74_18780	COG1051	belongs to the nudix hydrolase family
A6J74_18790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6J74_18800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J74_18810	COG2323	membrane
A6J74_18825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J74_18860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6J74_18875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J74_18910	COG1346	cytolysis
A6J74_18915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J74_18920	COG1647	Serine aminopeptidase, S33
A6J74_18925	COG0557	exoribonuclease II activity
A6J74_18975	COG2233	PERMEase
A6J74_18980	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
A6J74_18985	COG0288	reversible hydration of carbon dioxide
A6J74_18990	COG1522	sequence-specific DNA binding
A6J74_19005	COG1335	isochorismatase
A6J74_19020	COG3223	Belongs to the PsiE family
A6J74_19025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_19030	COG0488	(ABC) transporter
A6J74_19050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J74_19055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J74_19065	COG3290	protein histidine kinase activity
A6J74_19065	COG0840	transmembrane signaling receptor activity
A6J74_19080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J74_19085	COG1252	NADH dehydrogenase
A6J74_19095	COG1733	regulation of RNA biosynthetic process
A6J74_19100	COG2814	Major facilitator Superfamily
A6J74_19105	COG0656	L-ascorbic acid biosynthetic process
A6J74_19120	COG2910	NAD(P)H-binding
A6J74_19125	COG1115	amino acid carrier protein
A6J74_19130	COG1115	amino acid carrier protein
A6J74_19135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J74_19140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J74_19145	COG2311	Membrane
A6J74_19155	COG1528	Iron-storage protein
A6J74_19165	COG1611	Belongs to the LOG family
A6J74_19190	COG0783	Belongs to the Dps family
A6J74_19195	COG1115	amino acid carrier protein
A6J74_19205	COG0490	domain, Protein
A6J74_19210	COG0475	glutathione-regulated potassium exporter activity
A6J74_19215	COG0586	Pfam SNARE associated Golgi protein
A6J74_19235	COG3227	Zinc metalloprotease (Elastase)
A6J74_19240	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J74_19245	COG0840	transmembrane signaling receptor activity
A6J74_19250	COG0840	transmembrane signaling receptor activity
A6J74_19270	COG5002	protein histidine kinase activity
A6J74_19275	COG0745	RESPONSE REGULATOR receiver
A6J74_19280	COG1376	ErfK ybiS ycfS ynhG family protein
A6J74_19290	COG0586	Pfam SNARE associated Golgi protein
A6J74_19330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_19355	COG0531	amino acid
A6J74_19360	COG2814	Major facilitator Superfamily
A6J74_19375	COG0840	transmembrane signaling receptor activity
A6J74_19380	COG0011	TIGRFAM Protein of
A6J74_19390	COG0506	proline dehydrogenase activity
A6J74_19395	COG1686	Belongs to the peptidase S11 family
A6J74_19410	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6J74_19410	COG1024	Enoyl-CoA hydratase
A6J74_19415	COG0183	Belongs to the thiolase family
A6J74_19420	COG1960	acyl-CoA dehydrogenase activity
A6J74_19425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_19450	COG0039	L-malate dehydrogenase activity
A6J74_19470	COG1393	Belongs to the ArsC family
A6J74_19480	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A6J74_19485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J74_19505	COG2011	ABC-type metal ion transport system permease component
A6J74_19510	COG1464	Belongs to the NlpA lipoprotein family
A6J74_19515	COG1464	Belongs to the NlpA lipoprotein family
A6J74_19520	COG0396	ATPase activity
A6J74_19525	COG0719	Fe-S assembly protein
A6J74_19530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J74_19535	COG0822	iron-sulfur transferase activity
A6J74_19540	COG0719	Fe-S assembly protein
A6J74_19545	COG0737	Belongs to the 5'-nucleotidase family
A6J74_19550	COG3377	Domain of unknown function (DUF1805)
A6J74_19560	COG0739	heme binding
A6J74_19585	COG4377	Putative membrane peptidase family (DUF2324)
A6J74_19590	COG0789	Transcriptional regulator
A6J74_19600	COG4470	Protein conserved in bacteria
A6J74_19625	COG1494	fructose-1,6-bisphosphatase
A6J74_19630	COG2445	Protein of unknown function DUF86
A6J74_19640	COG0647	UMP catabolic process
A6J74_19650	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J74_19675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6J74_19680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6J74_19690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6J74_19695	COG4837	Protein of unknown function (DUF1462)
A6J74_19730	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J74_19735	COG0390	transport system, permease component
A6J74_19740	COG2274	protein secretion by the type I secretion system
A6J74_19750	COG1252	NADH dehydrogenase
A6J74_19765	COG0316	Belongs to the HesB IscA family
A6J74_19790	COG1683	Conserved Protein
A6J74_19805	COG3708	Transcriptional regulator
A6J74_19815	COG1252	NADH dehydrogenase
A6J74_19830	COG3584	3D domain protein
A6J74_19845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J74_19850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J74_19855	COG1268	BioY protein
A6J74_19865	COG2050	protein possibly involved in aromatic compounds catabolism
A6J74_19870	COG0423	glycine-tRNA ligase activity
A6J74_19890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6J74_19895	COG5018	Exonuclease
A6J74_19915	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6J74_19925	COG2267	carboxylic ester hydrolase activity
A6J74_19930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J74_19935	COG1522	sequence-specific DNA binding
A6J74_19940	COG0436	Aminotransferase
A6J74_19945	COG1098	S1 RNA binding domain
A6J74_19950	COG2155	Conserved Protein
A6J74_19970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J74_19975	COG1285	pathogenesis
A6J74_20015	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J74_20120	COG0039	L-malate dehydrogenase activity
A6J74_20150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J74_20160	COG0058	SHG alpha-glucan phosphorylase activity
A6J74_20185	COG1278	Cold shock
A6J74_20190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6J74_20195	COG1575	Belongs to the MenA family. Type 1 subfamily
A6J74_20200	COG1169	isochorismate synthase
A6J74_20210	COG0596	Alpha beta hydrolase
A6J74_20215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6J74_20225	COG4948	Mandelate Racemase Muconate Lactonizing
A6J74_20230	COG0745	RESPONSE REGULATOR receiver
A6J74_20245	COG3964	amidohydrolase
A6J74_20280	COG0577	efflux transmembrane transporter activity
A6J74_20285	COG1136	(ABC) transporter
A6J74_20290	COG0577	efflux transmembrane transporter activity
A6J74_20295	COG0577	efflux transmembrane transporter activity
A6J74_20300	COG2205	protein histidine kinase activity
A6J74_20305	COG0745	RESPONSE REGULATOR receiver
A6J74_20310	COG1595	DNA-templated transcription, initiation
A6J74_20325	COG0640	Transcriptional regulator
A6J74_20330	COG5658	integral membrane protein
A6J74_20335	COG1131	(ABC) transporter
A6J74_20345	COG2207	Transcriptional regulator
A6J74_20345	COG3708	Transcriptional regulator
A6J74_20350	COG1136	(ABC) transporter
A6J74_20355	COG0577	efflux transmembrane transporter activity
A6J74_20360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J74_20365	COG0586	Pfam SNARE associated Golgi protein
A6J74_20380	COG1136	(ABC) transporter
A6J74_20385	COG0577	efflux transmembrane transporter activity
A6J74_20410	COG1597	lipid kinase activity
A6J74_20440	COG0745	RESPONSE REGULATOR receiver
A6J74_20445	COG5002	protein histidine kinase activity
A6J74_20475	COG1842	Phage shock protein A
A6J74_20500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_20515	COG1294	oxidase, subunit
A6J74_20520	COG1271	oxidase subunit
A6J74_20525	COG0288	reversible hydration of carbon dioxide
A6J74_20565	COG0494	nUDIX hydrolase
A6J74_20590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J74_20595	COG1116	anion transmembrane transporter activity
A6J74_20600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J74_20615	COG1368	sulfuric ester hydrolase activity
A6J74_20620	COG2267	carboxylic ester hydrolase activity
A6J74_20630	COG3852	Histidine kinase
A6J74_20635	COG3852	Histidine kinase
A6J74_20705	COG0438	transferase activity, transferring glycosyl groups
A6J74_20710	COG0671	phosphoesterase, PA-phosphatase related
A6J74_20715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6J74_20720	COG2267	carboxylic ester hydrolase activity
A6J74_20735	COG1794	racemase activity, acting on amino acids and derivatives
A6J74_20740	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6J74_20745	COG1242	4 iron, 4 sulfur cluster binding
A6J74_20765	COG1136	(ABC) transporter
A6J74_20780	COG0582	viral genome integration into host DNA
A6J74_20785	COG0490	domain, Protein
A6J74_20790	COG0475	glutathione-regulated potassium exporter activity
A6J74_20795	COG2814	Major facilitator Superfamily
A6J74_20840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A6J74_20850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J74_20870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6J74_20875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J74_20885	COG0303	'Molybdopterin
A6J74_20890	COG1763	Mo-molybdopterin cofactor biosynthetic process
A6J74_20895	COG0314	molybdopterin synthase activity
A6J74_20920	COG1329	Transcriptional regulator
A6J74_20945	COG3832	glyoxalase III activity
A6J74_20955	COG2814	Major facilitator Superfamily
A6J74_20965	COG2081	HI0933 family
A6J74_20970	COG2244	polysaccharide biosynthetic process
A6J74_20975	COG1187	pseudouridine synthase activity
A6J74_20980	COG1349	DNA-binding transcription factor activity
A6J74_20985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J74_21000	COG1523	belongs to the glycosyl hydrolase 13 family
A6J74_21005	COG0510	thiamine kinase activity
A6J74_21020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_21030	COG1363	Peptidase, m42
A6J74_21035	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A6J74_21040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J74_21050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J74_21060	COG1388	LysM domain
A6J74_21060	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J74_21065	COG1674	ftsk spoiiie
A6J74_21080	COG0789	Transcriptional regulator
A6J74_21085	COG0697	spore germination
A6J74_21110	COG2309	aminopeptidase activity
A6J74_21120	COG3118	belongs to the thioredoxin family
A6J74_21125	COG4851	CamS sex pheromone cAM373 precursor
A6J74_21140	COG1609	Transcriptional regulator
A6J74_21170	COG0666	response to abiotic stimulus
A6J74_21175	COG5002	protein histidine kinase activity
A6J74_21180	COG0745	RESPONSE REGULATOR receiver
A6J74_21195	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6J74_21200	COG0517	IMP dehydrogenase activity
A6J74_21205	COG0454	-acetyltransferase
A6J74_21210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J74_21215	COG0110	maltose O-acetyltransferase activity
A6J74_21225	COG1595	DNA-templated transcription, initiation
A6J74_21235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J74_21265	COG0626	cystathionine gamma-synthase activity
A6J74_21270	COG1956	GAF domain-containing protein
A6J74_21275	COG1309	transcriptional regulator
A6J74_21280	COG0697	spore germination
A6J74_21285	COG0583	DNA-binding transcription factor activity
A6J74_21295	COG1104	cysteine desulfurase activity
A6J74_21310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J74_21320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A6J74_21335	COG3874	Sporulation protein YtfJ
A6J74_21340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6J74_21345	COG0827	DNA restriction-modification system
A6J74_21370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_21415	COG0346	lactoylglutathione lyase activity
A6J74_21420	COG0589	response to stress
A6J74_21425	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_21440	COG0662	Cupin 2, conserved barrel domain protein
A6J74_21475	COG0006	proline dipeptidase activity
A6J74_21490	COG4109	DRTGG domain
A6J74_21505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J74_21520	COG0587	DNA-directed DNA polymerase activity
A6J74_21525	COG0281	malic enzyme
A6J74_21530	COG1725	Transcriptional regulator
A6J74_21555	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6J74_21560	COG0628	permease
A6J74_21575	COG0372	Belongs to the citrate synthase family
A6J74_21580	COG0538	isocitrate dehydrogenase activity
A6J74_21605	COG0745	RESPONSE REGULATOR receiver
A6J74_21610	COG5002	protein histidine kinase activity
A6J74_21615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J74_21615	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J74_21625	COG1971	Probably functions as a manganese efflux pump
A6J74_21630	COG0237	dephospho-CoA kinase activity
A6J74_21635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J74_21645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A6J74_21660	COG3611	Membrane attachment protein
A6J74_21665	COG1484	DNA-dependent DNA replication
A6J74_21675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6J74_21680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6J74_21700	COG1363	Peptidase, m42
A6J74_21705	COG1309	transcriptional regulator
A6J74_21710	COG1566	PFAM secretion protein HlyD family protein
A6J74_21715	COG2814	Major facilitator Superfamily
A6J74_21735	COG1418	mRNA catabolic process
A6J74_21745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J74_21785	COG1286	toxin biosynthetic process
A6J74_21790	COG1796	DNA polymerase
A6J74_21790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6J74_21805	COG1187	pseudouridine synthase activity
A6J74_21810	COG1114	Component of the transport system for branched-chain amino acids
A6J74_21815	COG5386	Cell surface protein
A6J74_21825	COG5386	Cell surface protein
A6J74_21840	COG1120	ATPase activity
A6J74_21845	COG4509	Sortase family
A6J74_21855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J74_21860	COG4895	conserved protein (DUF2196)
A6J74_21870	COG0745	RESPONSE REGULATOR receiver
A6J74_21875	COG2205	protein histidine kinase activity
A6J74_21880	COG1131	(ABC) transporter
A6J74_21910	COG2318	DinB family
A6J74_21940	COG0318	PFAM AMP-dependent synthetase and ligase
A6J74_21945	COG1309	transcriptional regulator
A6J74_21950	COG1024	Enoyl-CoA hydratase
A6J74_21955	COG2086	electron transfer activity
A6J74_21960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A6J74_21965	COG3118	belongs to the thioredoxin family
A6J74_21975	COG1719	4-vinyl reductase, 4VR
A6J74_21980	COG2009	succinate dehydrogenase
A6J74_21985	COG1053	succinate dehydrogenase
A6J74_21990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J74_21995	COG0824	Thioesterase
A6J74_22000	COG1876	peptidase activity
A6J74_22005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6J74_22010	COG1360	Flagellar Motor Protein
A6J74_22015	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6J74_22020	COG4152	abc transporter atp-binding protein
A6J74_22025	COG1668	transmembrane transport
A6J74_22030	COG1959	2 iron, 2 sulfur cluster binding
A6J74_22040	COG0697	spore germination
A6J74_22045	COG1396	sequence-specific DNA binding
A6J74_22050	COG1983	PspC domain protein
A6J74_22055	COG0402	S-adenosylhomocysteine deaminase activity
A6J74_22060	COG2233	PERMEase
A6J74_22065	COG2197	response regulator
A6J74_22080	COG5401	PFAM Sporulation and spore germination
A6J74_22095	COG0622	Phosphoesterase
A6J74_22150	COG0470	DNA polymerase III
A6J74_22150	COG1067	ATP-dependent peptidase activity
A6J74_22165	COG1764	response to oxidative stress
A6J74_22170	COG1846	Transcriptional regulator
A6J74_22180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J74_22190	COG1587	Uroporphyrinogen-III synthase
A6J74_22195	COG0113	porphobilinogen synthase activity
A6J74_22205	COG1388	LysM domain
A6J74_22220	COG0285	dihydrofolate synthase activity
A6J74_22245	COG1077	Cell shape determining protein MreB Mrl
A6J74_22250	COG1792	Involved in formation and maintenance of cell shape
A6J74_22265	COG2894	cell division
A6J74_22270	COG0739	heme binding
A6J74_22275	COG1994	Peptidase M50
A6J74_22280	COG1530	ribonuclease E activity
A6J74_22290	COG2868	ribosomal protein
A6J74_22300	COG3290	protein histidine kinase activity
A6J74_22310	COG0745	RESPONSE REGULATOR receiver
A6J74_22315	COG5002	protein histidine kinase activity
A6J74_22320	COG1136	(ABC) transporter
A6J74_22325	COG0577	efflux transmembrane transporter activity
A6J74_22330	COG0577	efflux transmembrane transporter activity
A6J74_22335	COG0077	Prephenate dehydratase
A6J74_22340	COG2258	MOSC domain
A6J74_22345	COG1827	regulation of RNA biosynthetic process
A6J74_22350	COG1104	cysteine desulfurase activity
A6J74_22355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6J74_22360	COG0157	Belongs to the NadC ModD family
A6J74_22390	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A6J74_22420	COG1862	Preprotein translocase
A6J74_22430	COG2323	membrane
A6J74_22435	COG2244	polysaccharide biosynthetic process
A6J74_22445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J74_22445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J74_22450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J74_22455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J74_22455	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6J74_22465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J74_22505	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J74_22525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J74_22530	COG1959	2 iron, 2 sulfur cluster binding
A6J74_22535	COG1104	cysteine desulfurase activity
A6J74_22550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J74_22570	COG0628	permease
A6J74_22600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J74_22630	COG0768	penicillin binding
A6J74_22655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6J74_22660	COG0626	cystathionine gamma-synthase activity
A6J74_22665	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_22665	COG1454	alcohol dehydrogenase
A6J74_22680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A6J74_22720	COG2259	Doxx family
A6J74_22725	COG2514	catechol 2,3-dioxygenase activity
A6J74_22735	COG3186	Phenylalanine-4-hydroxylase
A6J74_22745	COG1404	Belongs to the peptidase S8 family
A6J74_22780	COG2267	carboxylic ester hydrolase activity
A6J74_22790	COG1785	Belongs to the alkaline phosphatase family
A6J74_22800	COG2357	RelA SpoT domain protein
A6J74_22805	COG0778	Nitroreductase
A6J74_22825	COG1191	sigma factor activity
A6J74_22840	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A6J74_22845	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J74_22855	COG1534	Rna-binding protein
A6J74_22865	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6J74_22870	COG0799	negative regulation of ribosome biogenesis
A6J74_22875	COG2226	methyltransferase
A6J74_22880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J74_22885	COG1555	photosystem II stabilization
A6J74_22885	COG1596	polysaccharide export
A6J74_22890	COG2131	deaminase
A6J74_22895	COG2333	competence protein COMEC
A6J74_22895	COG0658	competence protein
A6J74_22905	COG1466	dna polymerase III delta subunit
A6J74_22930	COG1733	regulation of RNA biosynthetic process
A6J74_22935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J74_22965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J74_22970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J74_22980	COG1610	YqeY-like protein
A6J74_23000	COG1702	phosphate starvation-inducible protein PhoH
A6J74_23005	COG1480	7TM receptor with intracellular HD hydrolase
A6J74_23015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J74_23020	COG0295	cytidine deaminase activity
A6J74_23025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J74_23040	COG0517	IMP dehydrogenase activity
A6J74_23050	COG1671	Belongs to the UPF0178 family
A6J74_23055	COG0358	DNA primase activity
A6J74_23060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J74_23065	COG2010	Cytochrome c
A6J74_23070	COG2384	SAM-dependent methyltransferase
A6J74_23075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J74_23105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_23110	COG1121	(ABC) transporter
A6J74_23115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J74_23120	COG0735	belongs to the Fur family
A6J74_23145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J74_23150	COG0477	Major facilitator Superfamily
A6J74_23160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J74_23165	COG0573	inorganic phosphate transmembrane transporter activity
A6J74_23170	COG0581	inorganic phosphate transmembrane transporter activity
A6J74_23180	COG0704	Plays a role in the regulation of phosphate uptake
A6J74_23185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6J74_23195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J74_23200	COG4483	Protein conserved in bacteria
A6J74_23205	COG1940	carbohydrate kinase activity
A6J74_23215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_23240	COG0626	cystathionine gamma-synthase activity
A6J74_23245	COG0626	cystathionine gamma-synthase activity
A6J74_23250	COG0646	methionine synthase
A6J74_23250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6J74_23255	COG1410	methionine synthase
A6J74_23255	COG0646	methionine synthase
A6J74_23310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J74_23315	COG1459	type II secretion system
A6J74_23325	COG4970	Tfp pilus assembly protein FimT
A6J74_23385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J74_23415	COG1725	Transcriptional regulator
A6J74_23420	COG1131	(ABC) transporter
A6J74_23455	COG2076	Multidrug Resistance protein
A6J74_23460	COG2076	Multidrug Resistance protein
A6J74_23470	COG1609	Transcriptional regulator
A6J74_23480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J74_23485	COG0095	Lipoate-protein ligase
A6J74_23515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J74_23525	COG3872	metal-dependent enzyme
A6J74_23540	COG0006	proline dipeptidase activity
A6J74_23565	COG3854	ATPases associated with a variety of cellular activities
A6J74_23610	COG0511	ligase activity, forming carbon-carbon bonds
A6J74_23615	COG0439	Biotin carboxylase
A6J74_23620	COG1302	Protein conserved in bacteria
A6J74_23645	COG0142	geranyltranstransferase activity
A6J74_23655	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6J74_23665	COG0497	DNA recombination
A6J74_23670	COG0750	zinc metalloprotease
A6J74_23680	COG0745	RESPONSE REGULATOR receiver
A6J74_23690	COG1215	transferase activity, transferring glycosyl groups
A6J74_23695	COG3093	addiction module antidote protein HigA
A6J74_23700	COG0584	glycerophosphoryl diester phosphodiesterase
A6J74_23710	COG3290	protein histidine kinase activity
A6J74_23710	COG3829	transcription factor binding
A6J74_23720	COG0280	phosphate acetyltransferase
A6J74_23725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J74_23735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J74_23740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J74_23745	COG0022	dehydrogenase e1 component
A6J74_23750	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J74_23760	COG0772	Belongs to the SEDS family
A6J74_23765	COG2323	membrane
A6J74_23790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J74_23795	COG0765	amino acid transport
A6J74_23800	COG1126	abc transporter atp-binding protein
A6J74_23805	COG4129	membrane
A6J74_23810	COG1376	ErfK ybiS ycfS ynhG family protein
A6J74_23825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J74_23830	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J74_23840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J74_23845	COG1285	pathogenesis
A6J74_23870	COG1760	l-serine dehydratase
A6J74_23875	COG1760	l-serine dehydratase
A6J74_23880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J74_23885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_23890	COG0300	oxidoreductase activity
A6J74_23935	COG1522	sequence-specific DNA binding
A6J74_23945	COG0737	Belongs to the 5'-nucleotidase family
A6J74_23965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J74_23980	COG2226	methyltransferase
A6J74_23980	COG1073	alpha beta
A6J74_23985	COG4106	trans-aconitate 2-methyltransferase activity
A6J74_24010	COG0307	riboflavin synthase, alpha
A6J74_24015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J74_24015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J74_24030	COG1073	alpha beta
A6J74_24035	COG0454	-acetyltransferase
A6J74_24040	COG1609	Transcriptional regulator
A6J74_24045	COG2056	Na+-H+ antiporter family
A6J74_24050	COG0596	Alpha beta hydrolase
A6J74_24060	COG0737	Belongs to the 5'-nucleotidase family
A6J74_24060	COG4085	toxin activity
A6J74_24060	COG1525	nuclease
A6J74_24070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A6J74_24070	COG0456	acetyltransferase
A6J74_24075	COG0656	L-ascorbic acid biosynthetic process
A6J74_24080	COG0667	Aldo Keto reductase
A6J74_24100	COG1300	Membrane
A6J74_24105	COG0735	belongs to the Fur family
A6J74_24115	COG4974	Belongs to the 'phage' integrase family
A6J74_24140	COG0598	Magnesium transport protein CorA
A6J74_24155	COG1846	Transcriptional regulator
A6J74_24180	COG1131	(ABC) transporter
A6J74_24185	COG1725	Transcriptional regulator
A6J74_24195	COG1686	Belongs to the peptidase S11 family
A6J74_24215	COG0733	neurotransmitter:sodium symporter activity
A6J74_24240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J74_24255	COG0697	spore germination
A6J74_24260	COG0561	phosphatase activity
A6J74_24265	COG4086	secreted protein
A6J74_24270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J74_24275	COG0456	acetyltransferase
A6J74_24280	COG1547	Domain of unknown function (DUF309)
A6J74_24310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6J74_24330	COG3711	transcriptional antiterminator
A6J74_24335	COG1263	PTS System
A6J74_24335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J74_24335	COG2190	(PTS) system
A6J74_24360	COG0778	Nitroreductase
A6J74_24365	COG2199	diguanylate cyclase activity
A6J74_24365	COG2203	Gaf domain
A6J74_24375	COG2084	Dehydrogenase
A6J74_24410	COG0436	Aminotransferase
A6J74_24415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J74_24435	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_24440	COG1695	Transcriptional regulator
A6J74_24475	COG0183	Belongs to the thiolase family
A6J74_24520	COG3842	ATPase activity
A6J74_24525	COG0366	Alpha amylase catalytic
A6J74_24535	COG2182	Extracellular solute-binding protein
A6J74_24540	COG1175	transmembrane transport
A6J74_24545	COG3833	ABC-type maltose transport systems, permease component
A6J74_24550	COG1609	Transcriptional regulator
A6J74_24555	COG0436	Aminotransferase
A6J74_24565	COG2205	protein histidine kinase activity
A6J74_24580	COG3209	COG3209 Rhs family protein
A6J74_24600	COG2814	Major facilitator Superfamily
A6J74_24635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6J74_24645	COG1408	metallophosphoesterase
A6J74_24650	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_24655	COG2200	EAL domain
A6J74_24670	COG4703	Protein of unknown function (DUF1797)
A6J74_24680	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A6J74_24690	COG0517	IMP dehydrogenase activity
A6J74_24695	COG0583	DNA-binding transcription factor activity
A6J74_24715	COG0569	domain protein
A6J74_24720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6J74_24735	COG0561	phosphatase activity
A6J74_24750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J74_24755	COG0022	dehydrogenase e1 component
A6J74_24815	COG1982	Orn Lys Arg decarboxylase major
A6J74_24840	COG0483	inositol monophosphate 1-phosphatase activity
A6J74_24865	COG4896	Protein conserved in bacteria
A6J74_24875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6J74_24880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6J74_24890	COG0772	Belongs to the SEDS family
A6J74_24900	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A6J74_24935	COG3336	cytochrome c oxidase
A6J74_24950	COG2340	Cysteine-rich secretory protein family
A6J74_24965	COG0406	alpha-ribazole phosphatase activity
A6J74_24970	COG3679	Belongs to the UPF0342 family
A6J74_24985	COG0742	ribosomal rna small subunit methyltransferase
A6J74_24995	COG3314	Sporulation integral membrane protein YlbJ
A6J74_25000	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6J74_25005	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6J74_25015	COG1399	metal-binding, possibly nucleic acid-binding protein
A6J74_25035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6J74_25060	COG0768	penicillin binding
A6J74_25080	COG0772	Belongs to the SEDS family
A6J74_25095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6J74_25100	COG0849	cell division
A6J74_25105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6J74_25115	COG1191	sigma factor activity
A6J74_25120	COG1191	sigma factor activity
A6J74_25125	COG1873	PFAM PRC-barrel domain
A6J74_25135	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J74_25140	COG1799	cell septum assembly
A6J74_25145	COG0762	integral membrane protein
A6J74_25150	COG2302	S4 RNA-binding domain
A6J74_25155	COG3599	regulation of cell shape
A6J74_25175	COG0564	pseudouridine synthase activity
A6J74_25235	COG3069	C4-dicarboxylate transmembrane transporter activity
A6J74_25255	COG0006	proline dipeptidase activity
A6J74_25265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J74_25270	COG1561	YicC-like family, N-terminal region
A6J74_25280	COG0194	GDP metabolic process
A6J74_25290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J74_25295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J74_25310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J74_25310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J74_25320	COG0631	protein serine/threonine phosphatase activity
A6J74_25325	COG2815	serine threonine protein kinase
A6J74_25325	COG0515	serine threonine protein kinase
A6J74_25330	COG1162	GTPase activity
A6J74_25335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J74_25340	COG1564	THIamine pyrophosphokinase
A6J74_25355	COG1302	Protein conserved in bacteria
A6J74_25360	COG1461	Dihydroxyacetone kinase
A6J74_25365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J74_25380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J74_25385	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_25400	COG1196	nuclear chromosome segregation
A6J74_25405	COG0552	protein localization to endoplasmic reticulum
A6J74_25415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J74_25425	COG1837	Belongs to the UPF0109 family
A6J74_25465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6J74_25470	COG0758	DNA mediated transformation
A6J74_25475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J74_25485	COG4974	Belongs to the 'phage' integrase family
A6J74_25515	COG0528	UMP kinase activity
A6J74_25530	COG4589	Belongs to the CDS family
A6J74_25540	COG0750	zinc metalloprotease
A6J74_25565	COG0195	Participates in both transcription termination and antitermination
A6J74_25570	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6J74_25575	COG1358	cellular component organization or biogenesis
A6J74_25585	COG1550	Protein conserved in bacteria
A6J74_25600	COG0196	riboflavin kinase activity
A6J74_25615	COG0726	polysaccharide deacetylase
A6J74_25620	COG0612	Peptidase, M16
A6J74_25625	COG1873	PFAM PRC-barrel domain
A6J74_25630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J74_25635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J74_25640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J74_25645	COG0527	aspartate kinase activity
A6J74_25655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6J74_25660	COG0740	serine-type endopeptidase activity
A6J74_25670	COG1674	ftsk spoiiie
A6J74_25680	COG2188	Transcriptional regulator
A6J74_25705	COG0612	Peptidase, M16
A6J74_25710	COG0612	Peptidase, M16
A6J74_25715	COG0300	oxidoreductase activity
A6J74_25730	COG1426	Protein conserved in bacteria
A6J74_25735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J74_25770	COG1692	metallophosphoesterase
A6J74_25775	COG2359	stage V sporulation protein S
A6J74_25785	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6J74_25785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6J74_25790	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6J74_25800	COG4550	Control of competence regulator ComK, YlbF/YmcA
A6J74_25830	COG1368	sulfuric ester hydrolase activity
A6J74_25845	COG3773	Cell wall hydrolase
A6J74_25850	COG1404	Belongs to the peptidase S8 family
A6J74_25870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6J74_25875	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J74_25875	COG0596	Alpha beta hydrolase
A6J74_25880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_25890	COG1346	cytolysis
A6J74_25930	COG5001	Diguanylate cyclase
A6J74_25930	COG3300	MHYT domain
A6J74_25950	COG2364	Membrane
A6J74_25960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6J74_25965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J74_25970	COG2169	Transcriptional regulator
A6J74_25975	COG0708	Exodeoxyribonuclease III
A6J74_25980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J74_25985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_25990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_25995	COG1120	ATPase activity
A6J74_26000	COG2819	hydrolase of the alpha beta superfamily
A6J74_26020	COG1937	Protein conserved in bacteria
A6J74_26025	COG2608	mercury ion transmembrane transporter activity
A6J74_26030	COG2217	Heavy metal translocating P-type atpase
A6J74_26050	COG1408	metallophosphoesterase
A6J74_26055	COG1473	amidohydrolase
A6J74_26070	COG1113	amino acid transport
A6J74_26085	COG2322	membrane
A6J74_26090	COG1979	alcohol dehydrogenase
A6J74_26095	COG1349	DNA-binding transcription factor activity
A6J74_26100	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J74_26105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J74_26105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J74_26105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J74_26110	COG1388	LysM domain
A6J74_26110	COG3584	3D domain protein
A6J74_26150	COG2860	membrane
A6J74_26155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J74_26160	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A6J74_26165	COG0789	Transcriptional regulator
A6J74_26170	COG0174	glutamine synthetase
A6J74_26190	COG1396	sequence-specific DNA binding
A6J74_26295	COG1595	DNA-templated transcription, initiation
A6J74_26300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J74_26450	COG5632	N-Acetylmuramoyl-L-alanine amidase
A6J74_26515	COG0741	lytic transglycosylase activity
A6J74_26515	COG0739	heme binding
A6J74_26515	COG1196	nuclear chromosome segregation
A6J74_26535	COG0489	protein tyrosine kinase activity
A6J74_26540	COG1086	Polysaccharide biosynthesis protein
A6J74_26545	COG0438	transferase activity, transferring glycosyl groups
A6J74_26550	COG0438	transferase activity, transferring glycosyl groups
A6J74_26555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A6J74_26555	COG0463	Glycosyl transferase, family 2
A6J74_26565	COG0438	transferase activity, transferring glycosyl groups
A6J74_26590	COG5434	Belongs to the glycosyl hydrolase 28 family
A6J74_26590	COG3420	alginic acid biosynthetic process
A6J74_26605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J74_26610	COG0367	asparagine synthase
A6J74_26635	COG1132	(ABC) transporter
A6J74_26640	COG1695	Transcriptional regulator
A6J74_26660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6J74_26670	COG0737	Belongs to the 5'-nucleotidase family
A6J74_26685	COG3639	organic phosphonate transmembrane transporter activity
A6J74_26710	COG1132	(ABC) transporter
A6J74_26715	COG1132	(ABC) transporter
A6J74_26745	COG0730	response to heat
A6J74_26755	COG1051	belongs to the nudix hydrolase family
A6J74_26760	COG1346	cytolysis
A6J74_26770	COG0583	DNA-binding transcription factor activity
A6J74_26785	COG1131	(ABC) transporter
A6J74_26810	COG0785	Cytochrome C biogenesis protein
A6J74_26815	COG4846	Membrane protein involved in cytochrome C biogenesis
A6J74_26845	COG2226	methyltransferase
A6J74_26870	COG0010	Belongs to the arginase family
A6J74_26875	COG1329	Transcriptional regulator
A6J74_26880	COG1902	pentaerythritol trinitrate reductase activity
A6J74_26885	COG0069	glutamate synthase activity
A6J74_26890	COG0346	lactoylglutathione lyase activity
A6J74_26895	COG0400	carboxylic ester hydrolase activity
A6J74_26900	COG5002	protein histidine kinase activity
A6J74_26910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_26950	COG1396	sequence-specific DNA binding
A6J74_26955	COG0318	PFAM AMP-dependent synthetase and ligase
A6J74_26960	COG1268	BioY protein
A6J74_26965	COG0318	PFAM AMP-dependent synthetase and ligase
A6J74_26970	COG0183	Belongs to the thiolase family
A6J74_26985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J74_26995	COG2211	Major facilitator Superfamily
A6J74_27015	COG0726	polysaccharide deacetylase
A6J74_27025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6J74_27040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J74_27065	COG0824	Thioesterase
A6J74_27070	COG4841	protein insertion into membrane
A6J74_27090	COG0745	RESPONSE REGULATOR receiver
A6J74_27095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J74_27100	COG1832	CoA-binding protein
A6J74_27110	COG0187	DNA topoisomerase II activity
A6J74_27115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J74_27120	COG0673	inositol 2-dehydrogenase activity
A6J74_27130	COG1131	(ABC) transporter
A6J74_27140	COG1595	DNA-templated transcription, initiation
A6J74_27150	COG1316	TRANSCRIPTIONal
A6J74_27155	COG1301	dicarboxylic acid transport
A6J74_27160	COG4166	transmembrane transport
A6J74_27165	COG4166	transmembrane transport
A6J74_27170	COG4166	transmembrane transport
A6J74_27175	COG2226	methyltransferase
A6J74_27210	COG0531	amino acid
A6J74_27230	COG3383	formate dehydrogenase (NAD+) activity
A6J74_27235	COG2427	Protein of unknown function (DUF1641)
A6J74_27240	COG5609	conserved protein (DUF2294)
A6J74_27245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J74_27260	COG2116	formate transmembrane transporter activity
A6J74_27265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J74_27270	COG0303	'Molybdopterin
A6J74_27275	COG0314	molybdopterin synthase activity
A6J74_27285	COG0489	protein tyrosine kinase activity
A6J74_27300	COG3326	Membrane
A6J74_27305	COG2962	Rard protein
A6J74_27310	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A6J74_27315	COG1657	PFAM Prenyltransferase squalene oxidase
A6J74_27325	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_27330	COG1012	belongs to the aldehyde dehydrogenase family
A6J74_27340	COG4145	pantothenate transmembrane transporter activity
A6J74_27355	COG0165	Argininosuccinate lyase
A6J74_27365	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_27395	COG0716	FMN binding
A6J74_27405	COG1278	Cold shock
A6J74_27430	COG2720	vancomycin resistance protein
A6J74_27435	COG2514	catechol 2,3-dioxygenase activity
A6J74_27445	COG1285	pathogenesis
A6J74_27455	COG3852	Histidine kinase
A6J74_27485	COG1876	peptidase activity
A6J74_27500	COG3300	MHYT domain
A6J74_27500	COG5001	Diguanylate cyclase
A6J74_27510	COG3858	chitin binding
A6J74_27525	COG0277	FAD linked oxidase domain protein
A6J74_27545	COG2808	Putative FMN-binding domain
A6J74_27555	COG0457	Tetratricopeptide repeat
A6J74_27565	COG0604	alcohol dehydrogenase
A6J74_27570	COG0640	Transcriptional regulator
A6J74_27580	COG0584	glycerophosphoryl diester phosphodiesterase
A6J74_27590	COG0583	DNA-binding transcription factor activity
A6J74_27605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J74_27620	COG3781	membrane
A6J74_27650	COG1164	Oligoendopeptidase f
A6J74_27655	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A6J74_27665	COG1193	negative regulation of DNA recombination
A6J74_27685	COG0583	DNA-binding transcription factor activity
A6J74_27715	COG3739	integral membrane protein
A6J74_27720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_27725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J74_27730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J74_27735	COG1247	-acetyltransferase
A6J74_27745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6J74_27750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A6J74_27805	COG2814	Major facilitator Superfamily
A6J74_27810	COG0456	acetyltransferase
A6J74_27815	COG1113	amino acid transport
A6J74_27820	COG0604	alcohol dehydrogenase
A6J74_27855	COG2072	flavoprotein involved in K transport
A6J74_27890	COG3409	Peptidoglycan-binding domain 1 protein
A6J74_27890	COG3757	hydrolase, family 25
A6J74_27905	COG1151	hydroxylamine reductase activity
A6J74_27965	COG1280	lysine exporter protein (LysE YggA)
A6J74_27975	COG1191	sigma factor activity
A6J74_27985	COG0726	polysaccharide deacetylase
A6J74_28015	COG1733	regulation of RNA biosynthetic process
A6J74_28020	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J74_28025	COG0318	PFAM AMP-dependent synthetase and ligase
A6J74_28055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J74_28080	COG0673	inositol 2-dehydrogenase activity
A6J74_28085	COG2188	Transcriptional regulator
A6J74_28090	COG1733	regulation of RNA biosynthetic process
A6J74_28100	COG1393	Belongs to the ArsC family
A6J74_28130	COG3655	Transcriptional regulator
A6J74_28135	COG0814	amino acid
A6J74_28190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J74_28200	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A6J74_28220	COG2706	6-phosphogluconolactonase activity
A6J74_28225	COG3813	Protein conserved in bacteria
A6J74_28230	COG1357	PFAM Pentapeptide repeats (8 copies)
A6J74_28235	COG0697	spore germination
A6J74_28260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6J74_28270	COG0789	Transcriptional regulator
A6J74_28275	COG1253	flavin adenine dinucleotide binding
A6J74_28310	COG0477	Major facilitator Superfamily
A6J74_28340	COG0628	permease
A6J74_28350	COG0180	Tryptophanyl-tRNA synthetase
A6J74_28355	COG0110	maltose O-acetyltransferase activity
A6J74_28365	COG1940	carbohydrate kinase activity
A6J74_28370	COG0346	lactoylglutathione lyase activity
A6J74_28405	COG1011	Hydrolase
A6J74_28435	COG1131	(ABC) transporter
A6J74_28445	COG1028	Short-chain dehydrogenase reductase Sdr
A6J74_28485	COG0778	Nitroreductase
A6J74_28490	COG1733	regulation of RNA biosynthetic process
A6J74_28510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J74_28515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J74_28525	COG2356	endonuclease I
A6J74_28530	COG1288	antiporter activity
A6J74_28585	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J74_28595	COG2031	fatty acid transporter
A6J74_28635	COG2814	Major facilitator Superfamily
A6J74_28640	COG1846	Transcriptional regulator
A6J74_28655	COG0477	Major facilitator Superfamily
A6J74_28680	COG0534	Mate efflux family protein
A6J74_28695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J74_28705	COG2843	Capsule synthesis protein
A6J74_28710	COG1876	peptidase activity
A6J74_28775	COG2814	Major facilitator Superfamily
A6J74_28830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J74_28850	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J74_28865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J74_28875	COG5002	protein histidine kinase activity
A6J74_28875	COG3850	Histidine kinase
A6J74_28895	COG0577	efflux transmembrane transporter activity
A6J74_28915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A6J74_28935	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A6J74_28940	COG2814	Major facilitator Superfamily
A6J74_28945	COG0384	phenazine biosynthesis protein PhzF
A6J74_29015	COG0346	lactoylglutathione lyase activity
A6J74_29030	COG1522	sequence-specific DNA binding
A6J74_29045	COG0697	spore germination
A6J74_29050	COG0814	amino acid
A6J74_29065	COG2186	Transcriptional regulator
A6J74_29090	COG0825	malonyl-CoA metabolic process
A6J74_29110	COG0640	Transcriptional regulator
A6J74_29115	COG0346	lactoylglutathione lyase activity
A6J74_29120	COG0798	PFAM Bile acid sodium symporter
A6J74_29150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6J74_29155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J74_29160	COG1999	signal sequence binding
A6J74_29175	COG1121	(ABC) transporter
A6J74_29180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J74_29185	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J74_29190	COG1575	Belongs to the MenA family. Type 1 subfamily
A6J74_29195	COG0456	acetyltransferase
A6J74_29205	COG0745	RESPONSE REGULATOR receiver
A6J74_29210	COG5002	protein histidine kinase activity
A6J74_29220	COG0726	polysaccharide deacetylase
A6J74_29240	COG0583	DNA-binding transcription factor activity
A6J74_29245	COG2814	Major facilitator Superfamily
A6J74_29250	COG5609	conserved protein (DUF2294)
A6J74_29255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J74_29265	COG0288	reversible hydration of carbon dioxide
A6J74_29270	COG0415	Belongs to the DNA photolyase family
A6J74_29315	COG1846	Transcriptional regulator
A6J74_29320	COG0583	DNA-binding transcription factor activity
A6J74_29340	COG1335	isochorismatase
A6J74_29345	COG2267	carboxylic ester hydrolase activity
A6J74_29355	COG0737	Belongs to the 5'-nucleotidase family
A6J74_29360	COG1876	peptidase activity
A6J74_29375	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J74_29390	COG3848	Pyruvate phosphate dikinase
A6J74_29390	COG0574	Belongs to the PEP-utilizing enzyme family
A6J74_29410	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A6J74_29460	COG1960	acyl-CoA dehydrogenase activity
A6J74_29490	COG1414	Transcriptional regulator
A6J74_29495	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6J74_29500	COG1984	allophanate hydrolase subunit 2
A6J74_29565	COG4335	DNA alkylation repair
A6J74_29575	COG0833	amino acid
A6J74_29585	COG0730	response to heat
A6J74_29630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J74_29650	COG0456	acetyltransferase
A6J74_29655	COG4977	sequence-specific DNA binding
A6J74_29685	COG3831	ATPase activity
A6J74_29685	COG4884	unkown
A6J74_29715	COG1846	Transcriptional regulator
A6J74_29720	COG0778	Nitroreductase
A6J74_30125	COG0464	growth
A6J74_30140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J74_30145	COG1181	Belongs to the D-alanine--D-alanine ligase family