locus-tag	class	description
MT476_00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MT476_00015	COG0594	ribonuclease P activity
MT476_00020	COG0706	membrane insertase activity
MT476_00025	COG1847	R3H domain protein
MT476_00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MT476_00035	COG0445	tRNA wobble uridine modification
MT476_00045	COG1475	DNA binding
MT476_00050	COG1192	Involved in chromosome partitioning
MT476_00055	COG1475	DNA binding
MT476_00065	COG3949	Membrane
MT476_00070	COG0668	transmembrane transport
MT476_00075	COG4481	Protein conserved in bacteria
MT476_00080	COG0012	GTP binding
MT476_00085	COG0360	Binds together with S18 to 16S ribosomal RNA
MT476_00095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MT476_00105	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MT476_00115	COG0305	Participates in initiation and elongation during chromosome replication
MT476_00120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MT476_00145	COG0745	RESPONSE REGULATOR receiver
MT476_00150	COG5002	protein histidine kinase activity
MT476_00160	COG4853	Protein conserved in bacteria
MT476_00165	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MT476_00170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MT476_00180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MT476_00185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MT476_00200	COG5002	protein histidine kinase activity
MT476_00200	COG3850	Histidine kinase
MT476_00215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MT476_00220	COG0471	metal ion transport
MT476_00235	COG5002	protein histidine kinase activity
MT476_00240	COG0753	catalase activity
MT476_00245	COG1966	Carbon starvation protein
MT476_00260	COG2814	Major facilitator Superfamily
MT476_00270	COG1609	Transcriptional regulator
MT476_00275	COG2966	Psort location CytoplasmicMembrane, score
MT476_00280	COG3610	response to peptide
MT476_00285	COG1271	oxidase subunit
MT476_00290	COG1294	oxidase, subunit
MT476_00295	COG4988	ABC transporter
MT476_00300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MT476_00315	COG0728	peptidoglycan biosynthetic process
MT476_00325	COG2076	Multidrug Resistance protein
MT476_00340	COG0438	transferase activity, transferring glycosyl groups
MT476_00350	COG1263	PTS System
MT476_00350	COG2190	(PTS) system
MT476_00350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_00355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MT476_00360	COG0561	phosphatase activity
MT476_00365	COG0351	phosphomethylpyrimidine kinase
MT476_00375	COG0686	Belongs to the AlaDH PNT family
MT476_00380	COG2508	Transcriptional regulator
MT476_00380	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MT476_00385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MT476_00390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MT476_00400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MT476_00410	COG2363	Small membrane protein
MT476_00420	COG3773	Cell wall hydrolase
MT476_00425	COG3253	May function as heme-dependent peroxidase
MT476_00430	COG0280	phosphate acetyltransferase
MT476_00435	COG0095	Lipoate-protein ligase
MT476_00445	COG4844	belongs to the
MT476_00450	COG1078	dGTPase activity
MT476_00455	COG3465	dGTPase activity
MT476_00460	COG1942	4-Oxalocrotonate Tautomerase
MT476_00465	COG1994	Peptidase M50
MT476_00475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MT476_00480	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MT476_00485	COG0010	Belongs to the arginase family
MT476_00490	COG4506	Protein conserved in bacteria
MT476_00495	COG0018	arginyl-trna synthetase
MT476_00500	COG4294	response to UV
MT476_00505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MT476_00510	COG0247	lactate metabolic process
MT476_00510	COG2181	nitrate reductase activity
MT476_00515	COG0183	Belongs to the thiolase family
MT476_00520	COG1250	3-hydroxyacyl-CoA dehydrogenase
MT476_00525	COG1960	acyl-CoA dehydrogenase activity
MT476_00530	COG1960	acyl-CoA dehydrogenase activity
MT476_00540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MT476_00540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MT476_00540	COG1703	isobutyryl-CoA mutase activity
MT476_00550	COG0504	CTP synthase activity
MT476_00555	COG4821	SIS domain
MT476_00560	COG2204	response regulator
MT476_00565	COG0191	fructose-bisphosphate aldolase activity
MT476_00570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MT476_00580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MT476_00595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MT476_00615	COG0009	L-threonylcarbamoyladenylate synthase
MT476_00620	COG1971	Probably functions as a manganese efflux pump
MT476_00630	COG0698	ribose 5-phosphate isomerase
MT476_00645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MT476_00650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MT476_00655	COG1404	Belongs to the peptidase S8 family
MT476_00670	COG0356	it plays a direct role in the translocation of protons across the membrane
MT476_00675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MT476_00680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MT476_00685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MT476_00690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MT476_00695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MT476_00700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MT476_00705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MT476_00710	COG4836	Membrane
MT476_00725	COG2385	sporulation resulting in formation of a cellular spore
MT476_00730	COG0739	heme binding
MT476_00735	COG1609	Transcriptional regulator
MT476_00740	COG1077	Cell shape determining protein MreB Mrl
MT476_00745	COG4786	Flagellar basal body rod
MT476_00750	COG4786	Flagellar basal body rod
MT476_00770	COG0629	single-stranded DNA binding
MT476_00775	COG1388	LysM domain
MT476_00775	COG0791	NLP P60 protein
MT476_00780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MT476_00790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MT476_00805	COG2268	Band 7 protein
MT476_00810	COG1585	Membrane protein implicated in regulation of membrane protease activity
MT476_00815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MT476_00820	COG1316	TRANSCRIPTIONal
MT476_00825	COG1739	Uncharacterized protein family UPF0029
MT476_00830	COG4585	Histidine kinase
MT476_00835	COG2197	response regulator
MT476_00845	COG1728	Protein conserved in bacteria
MT476_00850	COG1307	EDD domain protein, DegV family
MT476_00855	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MT476_00860	COG1040	competence protein
MT476_00880	COG4786	Flagellar basal body rod
MT476_00880	COG1256	bacterial-type flagellum assembly
MT476_00885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MT476_00890	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MT476_00895	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MT476_00900	COG1510	regulation of RNA biosynthetic process
MT476_00905	COG1454	alcohol dehydrogenase
MT476_00910	COG1012	belongs to the aldehyde dehydrogenase family
MT476_00920	COG1113	amino acid transport
MT476_00930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MT476_00935	COG1516	flagellar protein fliS
MT476_00945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MT476_00955	COG0653	protein targeting
MT476_00965	COG3540	Alkaline phosphatase
MT476_00970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MT476_00975	COG0805	protein transport
MT476_00985	COG0655	NAD(P)H dehydrogenase (quinone) activity
MT476_00990	COG2884	Cell division ATP-binding protein ftsE
MT476_00995	COG2177	Part of the ABC transporter FtsEX involved in
MT476_01000	COG0739	heme binding
MT476_01005	COG3409	Peptidoglycan-binding domain 1 protein
MT476_01005	COG0793	Belongs to the peptidase S41A family
MT476_01010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MT476_01015	COG4897	Protein conserved in bacteria
MT476_01020	COG0506	proline dehydrogenase activity
MT476_01025	COG2204	response regulator
MT476_01030	COG0556	nucleotide-excision repair
MT476_01035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MT476_01045	COG3595	metallopeptidase activity
MT476_01050	COG1983	PspC domain protein
MT476_01055	COG1950	PFAM Membrane protein of
MT476_01060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MT476_01065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MT476_01070	COG0546	phosphoglycolate phosphatase activity
MT476_01075	COG0110	maltose O-acetyltransferase activity
MT476_01080	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MT476_01085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MT476_01090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MT476_01095	COG0131	Imidazoleglycerol-phosphate dehydratase
MT476_01100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MT476_01105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MT476_01110	COG0107	imidazoleglycerol-phosphate synthase activity
MT476_01115	COG0140	phosphoribosyl-ATP diphosphatase activity
MT476_01115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MT476_01120	COG0457	Tetratricopeptide repeat
MT476_01125	COG0492	ferredoxin-NADP+ reductase activity
MT476_01130	COG1051	belongs to the nudix hydrolase family
MT476_01135	COG1660	Displays ATPase and GTPase activities
MT476_01140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MT476_01150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MT476_01170	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MT476_01210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MT476_01215	COG1647	Serine aminopeptidase, S33
MT476_01220	COG0557	exoribonuclease II activity
MT476_01225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MT476_01235	COG4149	molybdate abc transporter
MT476_01240	COG0725	ABC transporter, periplasmic molybdate-binding protein
MT476_01245	COG2427	Protein of unknown function (DUF1641)
MT476_01250	COG3383	formate dehydrogenase (NAD+) activity
MT476_01255	COG5609	conserved protein (DUF2294)
MT476_01260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MT476_01270	COG0746	molybdenum cofactor guanylyltransferase activity
MT476_01275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MT476_01280	COG0303	'Molybdopterin
MT476_01285	COG1763	Mo-molybdopterin cofactor biosynthetic process
MT476_01290	COG0314	molybdopterin synthase activity
MT476_01295	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MT476_01300	COG0778	Nitroreductase
MT476_01305	COG1846	Transcriptional regulator
MT476_01310	COG0671	phosphoesterase, PA-phosphatase related
MT476_01315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MT476_01320	COG0745	RESPONSE REGULATOR receiver
MT476_01325	COG5002	protein histidine kinase activity
MT476_01325	COG3850	Histidine kinase
MT476_01330	COG0672	)-iron permease
MT476_01340	COG0583	DNA-binding transcription factor activity
MT476_01345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MT476_01350	COG0477	Major facilitator Superfamily
MT476_01355	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_01365	COG1309	transcriptional regulator
MT476_01370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MT476_01385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MT476_01390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_01395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_01400	COG1120	ATPase activity
MT476_01425	COG1024	Enoyl-CoA hydratase
MT476_01425	COG1250	3-hydroxyacyl-CoA dehydrogenase
MT476_01430	COG0183	Belongs to the thiolase family
MT476_01435	COG1960	acyl-CoA dehydrogenase activity
MT476_01440	COG1393	Belongs to the ArsC family
MT476_01445	COG0509	glycine decarboxylation via glycine cleavage system
MT476_01455	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MT476_01460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MT476_01465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MT476_01470	COG2011	ABC-type metal ion transport system permease component
MT476_01475	COG1464	Belongs to the NlpA lipoprotein family
MT476_01480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MT476_01485	COG0396	ATPase activity
MT476_01490	COG0719	Fe-S assembly protein
MT476_01495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MT476_01500	COG0822	iron-sulfur transferase activity
MT476_01505	COG0719	Fe-S assembly protein
MT476_01510	COG1801	Protein of unknown function DUF72
MT476_01515	COG3377	Domain of unknown function (DUF1805)
MT476_01525	COG0733	neurotransmitter:sodium symporter activity
MT476_01535	COG0739	heme binding
MT476_01540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MT476_01550	COG4470	Protein conserved in bacteria
MT476_01560	COG2445	Protein of unknown function DUF86
MT476_01565	COG0647	UMP catabolic process
MT476_01570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MT476_01575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MT476_01580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MT476_01585	COG0460	homoserine dehydrogenase
MT476_01590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MT476_01595	COG0083	homoserine kinase activity
MT476_01600	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MT476_01605	COG4837	Protein of unknown function (DUF1462)
MT476_01610	COG1252	NADH dehydrogenase
MT476_01615	COG4844	belongs to the
MT476_01620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MT476_01625	COG0316	Belongs to the HesB IscA family
MT476_01635	COG0492	ferredoxin-NADP+ reductase activity
MT476_01640	COG1252	NADH dehydrogenase
MT476_01650	COG3584	3D domain protein
MT476_01655	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MT476_01660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MT476_01665	COG2056	Na+-H+ antiporter family
MT476_01675	COG1418	mRNA catabolic process
MT476_01685	COG2050	protein possibly involved in aromatic compounds catabolism
MT476_01690	COG5018	Exonuclease
MT476_01705	COG2032	superoxide dismutase activity
MT476_01710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MT476_01715	COG2267	carboxylic ester hydrolase activity
MT476_01720	COG1522	sequence-specific DNA binding
MT476_01725	COG0436	Aminotransferase
MT476_01730	COG1098	S1 RNA binding domain
MT476_01735	COG2155	Conserved Protein
MT476_01740	COG1979	alcohol dehydrogenase
MT476_01745	COG1320	monovalent cation:proton antiporter activity
MT476_01750	COG2212	antiporter activity
MT476_01755	COG1863	multisubunit Na H antiporter MnhE subunit
MT476_01760	COG0651	ATP synthesis coupled electron transport
MT476_01765	COG1006	Multisubunit Na H antiporter MnhC subunit
MT476_01770	COG2111	Na H antiporter
MT476_01775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MT476_01775	COG2111	Na H antiporter
MT476_01785	COG0166	Belongs to the GPI family
MT476_01795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MT476_01800	COG0346	lactoylglutathione lyase activity
MT476_01805	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MT476_01815	COG0306	phosphate transporter
MT476_01825	COG0529	Catalyzes the synthesis of activated sulfate
MT476_01845	COG1285	pathogenesis
MT476_01850	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_01980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MT476_01985	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MT476_01990	COG0297	glycogen (starch) synthase activity
MT476_01995	COG0058	SHG alpha-glucan phosphorylase activity
MT476_02005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MT476_02010	COG1169	isochorismate synthase
MT476_02015	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MT476_02020	COG0596	Alpha beta hydrolase
MT476_02025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MT476_02030	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_02035	COG4948	Mandelate Racemase Muconate Lactonizing
MT476_02040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MT476_02045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MT476_02070	COG0716	FMN binding
MT476_02075	COG1294	oxidase, subunit
MT476_02080	COG1271	oxidase subunit
MT476_02085	COG0254	rRNA binding
MT476_02095	COG0523	cobalamin synthesis protein
MT476_02100	COG0288	reversible hydration of carbon dioxide
MT476_02105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MT476_02115	COG0783	Belongs to the Dps family
MT476_02120	COG4824	toxin secretion phage lysis holin
MT476_02130	COG0494	nUDIX hydrolase
MT476_02135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MT476_02140	COG1116	anion transmembrane transporter activity
MT476_02145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MT476_02150	COG1506	peptidase
MT476_02160	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MT476_02165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MT476_02170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MT476_02170	COG0438	transferase activity, transferring glycosyl groups
MT476_02175	COG0671	phosphoesterase, PA-phosphatase related
MT476_02180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MT476_02185	COG2267	carboxylic ester hydrolase activity
MT476_02195	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MT476_02200	COG1242	4 iron, 4 sulfur cluster binding
MT476_02215	COG2814	Major facilitator Superfamily
MT476_02220	COG2610	gluconate transmembrane transporter activity
MT476_02225	COG0495	leucyl-tRNA aminoacylation
MT476_02230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MT476_02240	COG2081	HI0933 family
MT476_02245	COG2244	polysaccharide biosynthetic process
MT476_02250	COG1187	pseudouridine synthase activity
MT476_02255	COG1349	DNA-binding transcription factor activity
MT476_02260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MT476_02270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MT476_02275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MT476_02285	COG1523	belongs to the glycosyl hydrolase 13 family
MT476_02290	COG0510	thiamine kinase activity
MT476_02300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MT476_02305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_02310	COG5584	Small secreted protein
MT476_02315	COG1363	Peptidase, m42
MT476_02320	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MT476_02325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MT476_02330	COG4848	Belongs to the UPF0354 family
MT476_02335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MT476_02340	COG1674	ftsk spoiiie
MT476_02350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MT476_02365	COG4980	gas vesicle protein
MT476_02370	COG3118	belongs to the thioredoxin family
MT476_02375	COG1605	Chorismate mutase
MT476_02375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MT476_02395	COG0123	including yeast histone deacetylase and acetoin utilization protein
MT476_02400	COG0517	IMP dehydrogenase activity
MT476_02405	COG0454	-acetyltransferase
MT476_02410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MT476_02425	COG1956	GAF domain-containing protein
MT476_02430	COG1309	transcriptional regulator
MT476_02435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MT476_02440	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MT476_02445	COG1114	Component of the transport system for branched-chain amino acids
MT476_02450	COG1104	cysteine desulfurase activity
MT476_02455	COG0301	tRNA thio-modification
MT476_02465	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MT476_02470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MT476_02475	COG0616	signal peptide processing
MT476_02480	COG1714	RDD family
MT476_02490	COG3874	Sporulation protein YtfJ
MT476_02495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MT476_02500	COG0827	DNA restriction-modification system
MT476_02505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MT476_02520	COG0137	argininosuccinate synthase activity
MT476_02525	COG0165	Argininosuccinate lyase
MT476_02540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MT476_02550	COG4109	DRTGG domain
MT476_02560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MT476_02575	COG0587	DNA-directed DNA polymerase activity
MT476_02580	COG0281	malic enzyme
MT476_02585	COG2186	Transcriptional regulator
MT476_02590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MT476_02595	COG0825	malonyl-CoA metabolic process
MT476_02605	COG3030	protein affecting phage T7 exclusion by the F plasmid
MT476_02610	COG0628	permease
MT476_02615	COG2707	UPF0756 membrane protein
MT476_02620	COG0372	Belongs to the citrate synthase family
MT476_02625	COG0538	isocitrate dehydrogenase activity
MT476_02630	COG0039	L-malate dehydrogenase activity
MT476_02640	COG0745	RESPONSE REGULATOR receiver
MT476_02645	COG5002	protein histidine kinase activity
MT476_02650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MT476_02650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MT476_02655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MT476_02660	COG1971	Probably functions as a manganese efflux pump
MT476_02670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MT476_02675	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MT476_02685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MT476_02690	COG3611	Membrane attachment protein
MT476_02695	COG1484	DNA-dependent DNA replication
MT476_02705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MT476_02710	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MT476_02715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MT476_02720	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MT476_02740	COG1363	Peptidase, m42
MT476_02750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MT476_02755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MT476_02760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MT476_02760	COG0072	phenylalanine-tRNA ligase activity
MT476_02765	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MT476_02770	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MT476_02775	COG1286	toxin biosynthetic process
MT476_02780	COG1796	DNA polymerase
MT476_02780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MT476_02785	COG1193	negative regulation of DNA recombination
MT476_02790	COG3766	membrane
MT476_02795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MT476_02800	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_02805	COG1309	transcriptional regulator
MT476_02810	COG1024	Enoyl-CoA hydratase
MT476_02815	COG2086	electron transfer activity
MT476_02820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MT476_02825	COG3118	belongs to the thioredoxin family
MT476_02835	COG0527	aspartate kinase activity
MT476_02840	COG1719	4-vinyl reductase, 4VR
MT476_02845	COG2009	succinate dehydrogenase
MT476_02850	COG1053	succinate dehydrogenase
MT476_02855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MT476_02860	COG0824	Thioesterase
MT476_02865	COG2197	response regulator
MT476_02875	COG0490	domain, Protein
MT476_02880	COG0475	glutathione-regulated potassium exporter activity
MT476_02885	COG1116	anion transmembrane transporter activity
MT476_02890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MT476_02895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MT476_02900	COG0431	NADPH-dependent FMN reductase
MT476_02905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_02915	COG0768	penicillin binding
MT476_02920	COG1392	Phosphate transport regulator
MT476_02925	COG0306	phosphate transporter
MT476_02935	COG1846	Transcriptional regulator
MT476_02940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MT476_02945	COG5401	PFAM Sporulation and spore germination
MT476_02955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MT476_02960	COG0622	Phosphoesterase
MT476_02970	COG0028	Belongs to the TPP enzyme family
MT476_02975	COG0440	acetolactate synthase activity
MT476_02980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MT476_02985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MT476_02995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MT476_03000	COG0066	3-isopropylmalate dehydratase activity
MT476_03005	COG1477	protein flavinylation
MT476_03005	COG0457	Tetratricopeptide repeat
MT476_03010	COG0544	peptidyl-prolyl cis-trans isomerase activity
MT476_03015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MT476_03020	COG1067	ATP-dependent peptidase activity
MT476_03020	COG0470	DNA polymerase III
MT476_03025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MT476_03030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MT476_03045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MT476_03050	COG0181	hydroxymethylbilane synthase activity
MT476_03055	COG1587	Uroporphyrinogen-III synthase
MT476_03060	COG0113	porphobilinogen synthase activity
MT476_03065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MT476_03070	COG1388	LysM domain
MT476_03075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MT476_03085	COG0525	valine-tRNA ligase activity
MT476_03090	COG0285	dihydrofolate synthase activity
MT476_03095	COG2322	membrane
MT476_03105	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MT476_03120	COG2003	Belongs to the UPF0758 family
MT476_03125	COG1077	Cell shape determining protein MreB Mrl
MT476_03130	COG1792	Involved in formation and maintenance of cell shape
MT476_03135	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MT476_03140	COG0850	regulation of cytokinetic process
MT476_03145	COG2894	cell division
MT476_03150	COG0739	heme binding
MT476_03155	COG1994	Peptidase M50
MT476_03170	COG2868	ribosomal protein
MT476_03180	COG3290	protein histidine kinase activity
MT476_03185	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MT476_03190	COG4492	Belongs to the UPF0735 family
MT476_03195	COG0077	Prephenate dehydratase
MT476_03200	COG1827	regulation of RNA biosynthetic process
MT476_03205	COG1104	cysteine desulfurase activity
MT476_03210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MT476_03215	COG0157	Belongs to the NadC ModD family
MT476_03220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MT476_03225	COG1388	LysM domain
MT476_03250	COG0632	four-way junction helicase activity
MT476_03255	COG2255	four-way junction helicase activity
MT476_03265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MT476_03270	COG0343	queuine tRNA-ribosyltransferase activity
MT476_03275	COG1862	Preprotein translocase
MT476_03285	COG2323	membrane
MT476_03290	COG2244	polysaccharide biosynthetic process
MT476_03300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MT476_03300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MT476_03305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MT476_03305	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MT476_03310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MT476_03315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MT476_03320	COG1490	D-aminoacyl-tRNA deacylase activity
MT476_03325	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_03335	COG0124	histidyl-tRNA synthetase
MT476_03340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MT476_03350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MT476_03355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MT476_03360	COG0573	inorganic phosphate transmembrane transporter activity
MT476_03365	COG0581	inorganic phosphate transmembrane transporter activity
MT476_03370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MT476_03375	COG1959	2 iron, 2 sulfur cluster binding
MT476_03380	COG1104	cysteine desulfurase activity
MT476_03385	COG0482	sulfurtransferase activity
MT476_03395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MT476_03410	COG0628	permease
MT476_03420	COG4472	Bacterial protein of unknown function (DUF965)
MT476_03430	COG3906	Belongs to the UPF0473 family
MT476_03435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MT476_03440	COG4122	O-methyltransferase activity
MT476_03445	COG0826	peptidase U32
MT476_03450	COG0826	peptidase U32
MT476_03455	COG0572	uridine kinase
MT476_03460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MT476_03465	COG1335	isochorismatase
MT476_03470	COG0768	penicillin binding
MT476_03485	COG2226	methyltransferase
MT476_03490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MT476_03495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MT476_03500	COG0626	cystathionine gamma-synthase activity
MT476_03525	COG1183	phosphatidylcholine synthase activity
MT476_03530	COG0688	phosphatidylethanolamine metabolic process
MT476_03540	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MT476_03545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MT476_03550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MT476_03555	COG1534	Rna-binding protein
MT476_03560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MT476_03565	COG1713	HD superfamily hydrolase involved in NAD metabolism
MT476_03570	COG0799	negative regulation of ribosome biogenesis
MT476_03575	COG2226	methyltransferase
MT476_03580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MT476_03585	COG1555	photosystem II stabilization
MT476_03585	COG1596	polysaccharide export
MT476_03590	COG2131	deaminase
MT476_03595	COG2333	competence protein COMEC
MT476_03595	COG0658	competence protein
MT476_03605	COG1466	dna polymerase III delta subunit
MT476_03610	COG0268	Binds directly to 16S ribosomal RNA
MT476_03615	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MT476_03625	COG0481	GTPase activity
MT476_03630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MT476_03635	COG1420	regulation of RNA biosynthetic process
MT476_03640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MT476_03655	COG2264	protein methyltransferase activity
MT476_03660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MT476_03665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MT476_03675	COG1610	YqeY-like protein
MT476_03680	COG1030	water channel activity
MT476_03705	COG1702	phosphate starvation-inducible protein PhoH
MT476_03710	COG1480	7TM receptor with intracellular HD hydrolase
MT476_03720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MT476_03725	COG0295	cytidine deaminase activity
MT476_03730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MT476_03745	COG0517	IMP dehydrogenase activity
MT476_03750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MT476_03755	COG1671	Belongs to the UPF0178 family
MT476_03760	COG0358	DNA primase activity
MT476_03765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MT476_03770	COG1960	acyl-CoA dehydrogenase activity
MT476_03775	COG2010	Cytochrome c
MT476_03780	COG2384	SAM-dependent methyltransferase
MT476_03785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MT476_03790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MT476_03800	COG0513	Belongs to the DEAD box helicase family
MT476_03805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MT476_03815	COG1121	(ABC) transporter
MT476_03820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MT476_03825	COG0735	belongs to the Fur family
MT476_03830	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MT476_03835	COG4709	membrane
MT476_03840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MT476_03845	COG1388	LysM domain
MT476_03850	COG2814	Major facilitator Superfamily
MT476_03860	COG1283	sodium-dependent phosphate transmembrane transporter activity
MT476_03865	COG2839	Protein conserved in bacteria
MT476_03900	COG0477	Major facilitator Superfamily
MT476_03905	COG0768	penicillin binding
MT476_03915	COG0704	Plays a role in the regulation of phosphate uptake
MT476_03935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MT476_03945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MT476_03960	COG0705	Rhomboid family
MT476_03960	COG0457	Tetratricopeptide repeat
MT476_03965	COG4483	Protein conserved in bacteria
MT476_03970	COG1940	carbohydrate kinase activity
MT476_03975	COG2866	Carboxypeptidase
MT476_03985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_03995	COG1393	Belongs to the ArsC family
MT476_04000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MT476_04005	COG1459	type II secretion system
MT476_04010	COG4537	Required for transformation and DNA binding
MT476_04015	COG4970	Tfp pilus assembly protein FimT
MT476_04045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MT476_04050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MT476_04055	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MT476_04065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MT476_04070	COG0095	Lipoate-protein ligase
MT476_04075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MT476_04080	COG1321	iron dependent repressor
MT476_04085	COG1752	Esterase of the alpha-beta hydrolase superfamily
MT476_04095	COG3872	metal-dependent enzyme
MT476_04105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MT476_04110	COG0006	proline dipeptidase activity
MT476_04115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MT476_04125	COG3854	ATPases associated with a variety of cellular activities
MT476_04165	COG0511	ligase activity, forming carbon-carbon bonds
MT476_04170	COG0439	Biotin carboxylase
MT476_04175	COG1302	Protein conserved in bacteria
MT476_04180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MT476_04190	COG1722	exodeoxyribonuclease VII activity
MT476_04205	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MT476_04215	COG0497	DNA recombination
MT476_04220	COG0750	zinc metalloprotease
MT476_04225	COG0745	RESPONSE REGULATOR receiver
MT476_04230	COG3104	oligopeptide transport
MT476_04235	COG3093	addiction module antidote protein HigA
MT476_04240	COG0584	glycerophosphoryl diester phosphodiesterase
MT476_04250	COG3829	transcription factor binding
MT476_04250	COG3290	protein histidine kinase activity
MT476_04255	COG0280	phosphate acetyltransferase
MT476_04270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MT476_04275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MT476_04280	COG0022	dehydrogenase e1 component
MT476_04285	COG0508	dehydrogenase complex catalyzes the overall conversion of
MT476_04290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MT476_04290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MT476_04295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MT476_04295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MT476_04300	COG1703	isobutyryl-CoA mutase activity
MT476_04310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MT476_04315	COG0765	amino acid transport
MT476_04320	COG1126	abc transporter atp-binding protein
MT476_04325	COG4129	membrane
MT476_04330	COG1376	ErfK ybiS ycfS ynhG family protein
MT476_04345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MT476_04350	COG2195	Cleaves the N-terminal amino acid of tripeptides
MT476_04355	COG0493	'glutamate synthase
MT476_04360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MT476_04360	COG0167	dihydroorotate dehydrogenase activity
MT476_04380	COG2508	Transcriptional regulator
MT476_04385	COG1012	belongs to the aldehyde dehydrogenase family
MT476_04390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MT476_04400	COG1902	pentaerythritol trinitrate reductase activity
MT476_04405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MT476_04410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_04415	COG0300	oxidoreductase activity
MT476_04430	COG1073	alpha beta
MT476_04435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MT476_04445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MT476_04460	COG0667	Aldo Keto reductase
MT476_04470	COG0494	nUDIX hydrolase
MT476_04475	COG1300	Membrane
MT476_04480	COG0735	belongs to the Fur family
MT476_04490	COG4974	Belongs to the 'phage' integrase family
MT476_04505	COG1686	Belongs to the peptidase S11 family
MT476_04540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MT476_04555	COG0697	spore germination
MT476_04565	COG4086	secreted protein
MT476_04570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MT476_04580	COG1547	Domain of unknown function (DUF309)
MT476_04590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MT476_04595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MT476_04600	COG1686	Belongs to the peptidase S11 family
MT476_04605	COG2715	membrane protein required for spore maturation
MT476_04610	COG0700	Nucleoside recognition
MT476_04615	COG1187	pseudouridine synthase activity
MT476_04620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MT476_04625	COG1333	cytochrome c biogenesis protein
MT476_04630	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MT476_04635	COG0745	RESPONSE REGULATOR receiver
MT476_04640	COG5002	protein histidine kinase activity
MT476_04645	COG0739	heme binding
MT476_04650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MT476_04655	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MT476_04660	COG1141	Ferredoxin
MT476_04670	COG0514	ATP-dependent DNA helicase (RecQ)
MT476_04675	COG1266	CAAX protease self-immunity
MT476_04690	COG1408	metallophosphoesterase
MT476_04695	COG0789	Transcriptional regulator
MT476_04700	COG4862	establishment of competence for transformation
MT476_04705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MT476_04710	COG0492	ferredoxin-NADP+ reductase activity
MT476_04715	COG0252	asparaginase activity
MT476_04720	COG2339	peptidase activity
MT476_04725	COG3409	Peptidoglycan-binding domain 1 protein
MT476_04725	COG3773	Cell wall hydrolase
MT476_04730	COG2959	enzyme of heme biosynthesis
MT476_04745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MT476_04755	COG0539	negative regulation of cytoplasmic translation
MT476_04760	COG1304	FMN binding
MT476_04765	COG2271	Major facilitator Superfamily
MT476_04800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MT476_04805	COG0776	regulation of translation
MT476_04810	COG0302	gtp cyclohydrolase
MT476_04820	COG0142	geranyltranstransferase activity
MT476_04825	COG2226	methyltransferase
MT476_04830	COG0142	geranyltranstransferase activity
MT476_04835	COG0105	UTP biosynthetic process
MT476_04840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MT476_04845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MT476_04850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MT476_04860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MT476_04865	COG0134	indole-3-glycerol-phosphate synthase activity
MT476_04880	COG0159	tryptophan synthase activity
MT476_04885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MT476_04890	COG0287	Prephenate dehydrogenase
MT476_04895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MT476_04900	COG0457	Tetratricopeptide repeat
MT476_04905	COG5582	Belongs to the UPF0302 family
MT476_04920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MT476_04930	COG4347	Protein of unknown function (DUF1405)
MT476_04950	COG3679	Belongs to the UPF0342 family
MT476_04960	COG4471	UPF0298 protein
MT476_04970	COG0742	ribosomal rna small subunit methyltransferase
MT476_04975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MT476_04980	COG3314	Sporulation integral membrane protein YlbJ
MT476_04985	COG1752	Esterase of the alpha-beta hydrolase superfamily
MT476_04990	COG3480	Lon protease (S16) C-terminal proteolytic domain
MT476_04995	COG1323	Belongs to the UPF0348 family
MT476_05000	COG1399	metal-binding, possibly nucleic acid-binding protein
MT476_05005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MT476_05010	COG1024	Enoyl-CoA hydratase
MT476_05020	COG0454	-acetyltransferase
MT476_05025	COG0439	Biotin carboxylase
MT476_05030	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MT476_05035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MT476_05040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MT476_05050	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MT476_05060	COG4839	cell division protein FtsL
MT476_05065	COG0768	penicillin binding
MT476_05070	COG0768	penicillin binding
MT476_05075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MT476_05080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MT476_05085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MT476_05090	COG0772	Belongs to the SEDS family
MT476_05095	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MT476_05100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MT476_05105	COG0849	cell division
MT476_05110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MT476_05120	COG1191	sigma factor activity
MT476_05125	COG1191	sigma factor activity
MT476_05130	COG1873	PFAM PRC-barrel domain
MT476_05140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MT476_05145	COG1799	cell septum assembly
MT476_05150	COG0762	integral membrane protein
MT476_05155	COG2302	S4 RNA-binding domain
MT476_05160	COG3599	regulation of cell shape
MT476_05175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MT476_05180	COG0564	pseudouridine synthase activity
MT476_05185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MT476_05195	COG0540	Belongs to the ATCase OTCase family
MT476_05200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MT476_05215	COG0543	2 iron, 2 sulfur cluster binding
MT476_05230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MT476_05240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MT476_05245	COG1561	YicC-like family, N-terminal region
MT476_05250	COG2052	Domain of unknown function (DUF370)
MT476_05255	COG0194	GDP metabolic process
MT476_05260	COG1758	RNA polymerase activity
MT476_05265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MT476_05270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MT476_05280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MT476_05285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MT476_05285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MT476_05295	COG0631	protein serine/threonine phosphatase activity
MT476_05300	COG0515	serine threonine protein kinase
MT476_05300	COG2815	serine threonine protein kinase
MT476_05305	COG1162	GTPase activity
MT476_05310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MT476_05315	COG1564	THIamine pyrophosphokinase
MT476_05325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MT476_05330	COG1302	Protein conserved in bacteria
MT476_05335	COG1461	Dihydroxyacetone kinase
MT476_05345	COG1760	l-serine dehydratase
MT476_05350	COG1760	l-serine dehydratase
MT476_05355	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MT476_05360	COG1349	DNA-binding transcription factor activity
MT476_05365	COG0416	fatty acid biosynthetic process
MT476_05370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MT476_05375	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_05385	COG0571	ribonuclease III activity
MT476_05390	COG1196	nuclear chromosome segregation
MT476_05395	COG0552	protein localization to endoplasmic reticulum
MT476_05405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MT476_05410	COG0228	four-way junction DNA binding
MT476_05415	COG1837	Belongs to the UPF0109 family
MT476_05425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MT476_05435	COG0335	large ribosomal subunit rRNA binding
MT476_05455	COG0045	succinate-CoA ligase (ADP-forming) activity
MT476_05460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MT476_05465	COG0758	DNA mediated transformation
MT476_05470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MT476_05475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MT476_05480	COG4974	Belongs to the 'phage' integrase family
MT476_05490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MT476_05495	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MT476_05500	COG1815	bacterial-type flagellum-dependent cell motility
MT476_05505	COG1558	bacterial-type flagellum-dependent cell motility
MT476_05510	COG1677	Flagellar hook-basal body complex protein FliE
MT476_05515	COG1766	The M ring may be actively involved in energy transduction
MT476_05520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MT476_05525	COG1317	bacterial-type flagellum organization
MT476_05530	COG1157	protein secretion by the type III secretion system
MT476_05535	COG2882	bacterial-type flagellum organization
MT476_05550	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MT476_05555	COG4786	Flagellar basal body rod
MT476_05560	COG1582	Flagellar protein (FlbD)
MT476_05570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MT476_05575	COG1776	CheC inhibitor of MCP methylation
MT476_05575	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MT476_05580	COG2201	protein-glutamate methylesterase activity
MT476_05585	COG3190	flagellar
MT476_05590	COG1338	Plays a role in the flagellum-specific transport system
MT476_05595	COG1987	bacterial-type flagellum assembly
MT476_05600	COG1684	flagellar biosynthetic protein fliR
MT476_05605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MT476_05610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MT476_05615	COG1419	protein localization to endoplasmic reticulum
MT476_05620	COG0455	bacterial-type flagellum organization
MT476_05625	COG2201	protein-glutamate methylesterase activity
MT476_05630	COG0643	Histidine kinase
MT476_05630	COG2198	Histidine kinase
MT476_05635	COG0835	chemotaxis
MT476_05640	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MT476_05645	COG1191	sigma factor activity
MT476_05660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MT476_05670	COG0233	cytoplasmic translational termination
MT476_05675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MT476_05680	COG4589	Belongs to the CDS family
MT476_05690	COG0750	zinc metalloprotease
MT476_05695	COG0442	prolyl-tRNA aminoacylation
MT476_05700	COG2176	DNA-directed DNA polymerase activity
MT476_05705	COG0779	Required for maturation of 30S ribosomal subunits
MT476_05710	COG0195	Participates in both transcription termination and antitermination
MT476_05715	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MT476_05720	COG1358	cellular component organization or biogenesis
MT476_05730	COG1550	Protein conserved in bacteria
MT476_05735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MT476_05745	COG0196	riboflavin kinase activity
MT476_05750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MT476_05755	COG1185	polyribonucleotide nucleotidyltransferase activity
MT476_05760	COG0726	polysaccharide deacetylase
MT476_05765	COG0612	Peptidase, M16
MT476_05770	COG1873	PFAM PRC-barrel domain
MT476_05775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MT476_05780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MT476_05785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MT476_05790	COG0527	aspartate kinase activity
MT476_05800	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MT476_05805	COG0740	serine-type endopeptidase activity
MT476_05815	COG1674	ftsk spoiiie
MT476_05815	COG4980	gas vesicle protein
MT476_05825	COG2188	Transcriptional regulator
MT476_05830	COG1744	ABC transporter substrate-binding protein PnrA-like
MT476_05835	COG3845	ABC transporter
MT476_05840	COG4603	Belongs to the binding-protein-dependent transport system permease family
MT476_05845	COG1079	Belongs to the binding-protein-dependent transport system permease family
MT476_05850	COG0612	Peptidase, M16
MT476_05855	COG0612	Peptidase, M16
MT476_05860	COG0300	oxidoreductase activity
MT476_05875	COG1426	Protein conserved in bacteria
MT476_05880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MT476_05885	COG1058	Belongs to the CinA family
MT476_05885	COG1546	Belongs to the CinA family
MT476_05890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MT476_05900	COG1692	metallophosphoesterase
MT476_05905	COG2359	stage V sporulation protein S
MT476_05920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MT476_05920	COG0674	pyruvate-flavodoxin oxidoreductase activity
MT476_05925	COG1013	pyruvate-flavodoxin oxidoreductase activity
MT476_05930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MT476_05935	COG4550	Control of competence regulator ComK, YlbF/YmcA
MT476_05945	COG0531	amino acid
MT476_05950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MT476_05960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MT476_05970	COG0464	growth
MT476_05975	COG2860	membrane
MT476_05980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MT476_05985	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MT476_05990	COG0789	Transcriptional regulator
MT476_05995	COG0174	glutamine synthetase
MT476_06005	COG0531	amino acid
MT476_06010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MT476_06015	COG0463	Glycosyl transferase, family 2
MT476_06050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MT476_06055	COG4224	UPF0291 protein
MT476_06075	COG1132	(ABC) transporter
MT476_06080	COG1132	(ABC) transporter
MT476_06090	COG0785	Cytochrome C biogenesis protein
MT476_06095	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MT476_06100	COG4846	Membrane protein involved in cytochrome C biogenesis
MT476_06110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MT476_06120	COG1012	belongs to the aldehyde dehydrogenase family
MT476_06140	COG3852	Histidine kinase
MT476_06145	COG0415	Belongs to the DNA photolyase family
MT476_06165	COG0076	glutamate decarboxylase activity
MT476_06195	COG0788	formyltetrahydrofolate deformylase activity
MT476_06200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MT476_06205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MT476_06215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MT476_06225	COG1307	EDD domain protein, DegV family
MT476_06235	COG1999	signal sequence binding
MT476_06240	COG2755	lipolytic protein G-D-S-L family
MT476_06270	COG4191	Histidine kinase
MT476_06280	COG1301	dicarboxylic acid transport
MT476_06285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MT476_06290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MT476_06295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MT476_06300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MT476_06305	COG0456	acetyltransferase
MT476_06310	COG1509	lysine 2,3-aminomutase activity
MT476_06325	COG3594	Acyltransferase
MT476_06330	COG4479	Belongs to the UPF0346 family
MT476_06355	COG0515	serine threonine protein kinase
MT476_06360	COG4326	sporulation control protein
MT476_06365	COG0671	phosphoesterase, PA-phosphatase related
MT476_06380	COG0813	purine-nucleoside phosphorylase activity
MT476_06385	COG0659	secondary active sulfate transmembrane transporter activity
MT476_06390	COG0772	Belongs to the SEDS family
MT476_06405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MT476_06415	COG2190	(PTS) system
MT476_06420	COG3711	transcriptional antiterminator
MT476_06425	COG1263	PTS System
MT476_06425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_06430	COG0706	membrane insertase activity
MT476_06445	COG3842	ATPase activity
MT476_06455	COG0584	glycerophosphoryl diester phosphodiesterase
MT476_06470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_06485	COG1131	(ABC) transporter
MT476_06510	COG0814	amino acid
MT476_06515	COG0697	spore germination
MT476_06520	COG0432	Pfam Uncharacterised protein family UPF0047
MT476_06530	COG0791	NLP P60 protein
MT476_06530	COG1388	LysM domain
MT476_06535	COG0205	6-phosphofructokinase activity
MT476_06545	COG0589	response to stress
MT476_06550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MT476_06560	COG1253	flavin adenine dinucleotide binding
MT476_06565	COG2340	Cysteine-rich secretory protein family
MT476_06570	COG0668	transmembrane transport
MT476_06575	COG0385	Bile acid
MT476_06585	COG1115	amino acid carrier protein
MT476_06590	COG1280	lysine exporter protein (LysE YggA)
MT476_06610	COG2514	catechol 2,3-dioxygenase activity
MT476_06615	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MT476_06635	COG0463	Glycosyl transferase, family 2
MT476_06665	COG1113	amino acid transport
MT476_06680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MT476_06690	COG4195	phage-related replication protein
MT476_06695	COG2226	methyltransferase
MT476_06700	COG1285	pathogenesis
MT476_06710	COG2910	NAD(P)H-binding
MT476_06715	COG1247	-acetyltransferase
MT476_06720	COG0730	response to heat
MT476_06725	COG0583	DNA-binding transcription factor activity
MT476_06735	COG1309	transcriptional regulator
MT476_06740	COG5505	Protein of unknown function (DUF819)
MT476_06745	COG1113	amino acid transport
MT476_06760	COG1902	pentaerythritol trinitrate reductase activity
MT476_06765	COG0697	spore germination
MT476_06775	COG1368	sulfuric ester hydrolase activity
MT476_06800	COG0753	catalase activity
MT476_06815	COG1301	dicarboxylic acid transport
MT476_06820	COG0730	response to heat
MT476_06825	COG2205	protein histidine kinase activity
MT476_06830	COG1609	Transcriptional regulator
MT476_06840	COG1653	transport
MT476_06850	COG0395	ABC-type sugar transport system, permease component
MT476_06860	COG2814	Major facilitator Superfamily
MT476_06875	COG0517	IMP dehydrogenase activity
MT476_06875	COG1125	glycine betaine transport
MT476_06880	COG1174	glycine betaine transport
MT476_06885	COG5522	Integral membrane protein (intg_mem_TP0381)
MT476_06890	COG2249	NAD(P)H dehydrogenase (quinone) activity
MT476_06910	COG0006	proline dipeptidase activity
MT476_06920	COG0697	spore germination
MT476_06925	COG1802	Transcriptional regulator
MT476_06930	COG1607	acyl-coa hydrolase
MT476_06935	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MT476_06940	COG2770	Histidine kinase
MT476_06940	COG2205	protein histidine kinase activity
MT476_06945	COG0745	RESPONSE REGULATOR receiver
MT476_06950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MT476_06960	COG1522	sequence-specific DNA binding
MT476_06970	COG0569	domain protein
MT476_06975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MT476_06995	COG0405	Gamma-glutamyltransferase
MT476_07005	COG0833	amino acid
MT476_07020	COG0697	spore germination
MT476_07030	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MT476_07035	COG0726	polysaccharide deacetylase
MT476_07040	COG1595	DNA-templated transcription, initiation
MT476_07050	COG1846	Transcriptional regulator
MT476_07055	COG0840	transmembrane signaling receptor activity
MT476_07060	COG0791	NLP P60 protein
MT476_07060	COG1388	LysM domain
MT476_07075	COG0463	Glycosyl transferase, family 2
MT476_07085	COG0463	Glycosyl transferase, family 2
MT476_07090	COG2259	Doxx family
MT476_07095	COG2124	cytochrome p450
MT476_07100	COG1733	regulation of RNA biosynthetic process
MT476_07105	COG1024	Enoyl-CoA hydratase
MT476_07110	COG3973	AAA domain
MT476_07125	COG3209	COG3209 Rhs family protein
MT476_07130	COG1937	Protein conserved in bacteria
MT476_07135	COG1289	transmembrane transporter activity
MT476_07145	COG0745	RESPONSE REGULATOR receiver
MT476_07150	COG0642	Histidine kinase
MT476_07160	COG1136	(ABC) transporter
MT476_07165	COG0577	efflux transmembrane transporter activity
MT476_07170	COG1752	Esterase of the alpha-beta hydrolase superfamily
MT476_07195	COG4980	gas vesicle protein
MT476_07200	COG1621	beta-fructofuranosidase activity
MT476_07215	COG0789	Transcriptional regulator
MT476_07225	COG0667	Aldo Keto reductase
MT476_07230	COG0789	Transcriptional regulator
MT476_07255	COG1247	-acetyltransferase
MT476_07285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MT476_07290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MT476_07340	COG3300	MHYT domain
MT476_07340	COG5001	Diguanylate cyclase
MT476_07345	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_07365	COG3878	Protein conserved in bacteria
MT476_07370	COG0506	proline dehydrogenase activity
MT476_07375	COG1012	belongs to the aldehyde dehydrogenase family
MT476_07380	COG1113	amino acid transport
MT476_07385	COG1113	amino acid transport
MT476_07400	COG1278	Cold shock
MT476_07425	COG1846	Transcriptional regulator
MT476_07430	COG2814	Major facilitator Superfamily
MT476_07435	COG0791	NLP P60 protein
MT476_07455	COG0670	Belongs to the BI1 family
MT476_07475	COG2851	Citrate transporter
MT476_07480	COG0583	DNA-binding transcription factor activity
MT476_07485	COG2828	Protein conserved in bacteria
MT476_07505	COG2244	polysaccharide biosynthetic process
MT476_07525	COG3845	ABC transporter
MT476_07530	COG4603	Belongs to the binding-protein-dependent transport system permease family
MT476_07535	COG1079	Belongs to the binding-protein-dependent transport system permease family
MT476_07540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MT476_07545	COG0521	Mo-molybdopterin cofactor biosynthetic process
MT476_07555	COG0303	'Molybdopterin
MT476_07585	COG2207	Transcriptional regulator
MT476_07585	COG3708	Transcriptional regulator
MT476_07590	COG3339	Conserved Protein
MT476_07595	COG1971	Probably functions as a manganese efflux pump
MT476_07695	COG3620	sequence-specific DNA binding
MT476_07705	COG0110	maltose O-acetyltransferase activity
MT476_07710	COG1309	transcriptional regulator
MT476_07715	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MT476_07730	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_07735	COG2814	Major facilitator Superfamily
MT476_07745	COG0583	DNA-binding transcription factor activity
MT476_07765	COG0745	RESPONSE REGULATOR receiver
MT476_07770	COG0745	RESPONSE REGULATOR receiver
MT476_07775	COG5002	protein histidine kinase activity
MT476_07780	COG0671	phosphoesterase, PA-phosphatase related
MT476_07790	COG1695	Transcriptional regulator
MT476_07805	COG0686	Belongs to the AlaDH PNT family
MT476_07820	COG0252	asparaginase activity
MT476_07835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_07835	COG2190	(PTS) system
MT476_07835	COG1263	PTS System
MT476_07845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MT476_07850	COG0156	8-amino-7-oxononanoate synthase activity
MT476_07855	COG1266	CAAX protease self-immunity
MT476_07925	COG1609	Transcriptional regulator
MT476_07930	COG0366	Alpha amylase catalytic
MT476_07935	COG1621	beta-fructofuranosidase activity
MT476_07940	COG4572	Cation transport regulator
MT476_07950	COG1309	transcriptional regulator
MT476_07955	COG0477	Major facilitator Superfamily
MT476_07965	COG0477	Major facilitator Superfamily
MT476_08000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MT476_08005	COG1819	glycosyl
MT476_08015	COG2259	Doxx family
MT476_08020	COG0346	lactoylglutathione lyase activity
MT476_08030	COG1335	isochorismatase
MT476_08040	COG2267	carboxylic ester hydrolase activity
MT476_08045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MT476_08065	COG1522	sequence-specific DNA binding
MT476_08070	COG0047	phosphoribosylformylglycinamidine synthase activity
MT476_08130	COG2311	Membrane
MT476_08145	COG2211	Major facilitator Superfamily
MT476_08150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MT476_08160	COG1501	Belongs to the glycosyl hydrolase 31 family
MT476_08170	COG2188	Transcriptional regulator
MT476_08175	COG1012	belongs to the aldehyde dehydrogenase family
MT476_08195	COG2249	NAD(P)H dehydrogenase (quinone) activity
MT476_08200	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_08235	COG1414	Transcriptional regulator
MT476_08240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MT476_08250	COG4948	Mandelate Racemase Muconate Lactonizing
MT476_08255	COG2271	Major facilitator Superfamily
MT476_08265	COG0789	Transcriptional regulator
MT476_08265	COG4978	Transcriptional regulator
MT476_08290	COG1733	regulation of RNA biosynthetic process
MT476_08300	COG0604	alcohol dehydrogenase
MT476_08315	COG2807	transmembrane transport
MT476_08325	COG0583	DNA-binding transcription factor activity
MT476_08335	COG2814	Major facilitator Superfamily
MT476_08340	COG1278	Cold shock
MT476_08360	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MT476_08365	COG5646	InterPro IPR014922
MT476_08415	COG1414	Transcriptional regulator
MT476_08430	COG2271	Major facilitator Superfamily
MT476_08435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MT476_08440	COG0129	dihydroxy-acid dehydratase activity
MT476_08445	COG2610	gluconate transmembrane transporter activity
MT476_08455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MT476_08465	COG2258	MOSC domain
MT476_08470	COG1388	LysM domain
MT476_08470	COG0791	NLP P60 protein
MT476_08475	COG0697	spore germination
MT476_08510	COG1846	Transcriptional regulator
MT476_08545	COG1918	ferrous iron import across plasma membrane
MT476_08545	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MT476_08550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MT476_08555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MT476_08575	COG1078	dGTPase activity
MT476_08580	COG1609	Transcriptional regulator
MT476_08595	COG2160	L-arabinose isomerase activity
MT476_08625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MT476_08635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MT476_08635	COG3153	acetyltransferase
MT476_08670	COG1280	lysine exporter protein (LysE YggA)
MT476_08690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MT476_08700	COG0561	phosphatase activity
MT476_08705	COG1349	DNA-binding transcription factor activity
MT476_08715	COG3619	membrane
MT476_08735	COG2186	Transcriptional regulator
MT476_08755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MT476_08760	COG0454	-acetyltransferase
MT476_08765	COG4335	DNA alkylation repair
MT476_08790	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_08800	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_08805	COG0598	Magnesium transport protein CorA
MT476_08825	COG1876	peptidase activity
MT476_08830	COG5001	Diguanylate cyclase
MT476_08835	COG3290	protein histidine kinase activity
MT476_08835	COG0840	transmembrane signaling receptor activity
MT476_08850	COG1278	Cold shock
MT476_08855	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_08875	COG0662	Cupin 2, conserved barrel domain protein
MT476_08890	COG0789	Transcriptional regulator
MT476_08895	COG1064	alcohol dehydrogenase
MT476_08910	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_08915	COG0583	DNA-binding transcription factor activity
MT476_08935	COG2323	membrane
MT476_08950	COG0659	secondary active sulfate transmembrane transporter activity
MT476_08965	COG1131	(ABC) transporter
MT476_08980	COG0745	RESPONSE REGULATOR receiver
MT476_08995	COG1404	Belongs to the peptidase S8 family
MT476_09005	COG2329	Antibiotic biosynthesis monooxygenase
MT476_09020	COG2312	Erythromycin esterase
MT476_09030	COG0561	phosphatase activity
MT476_09070	COG0772	Belongs to the SEDS family
MT476_09120	COG1904	glucuronate isomerase
MT476_09130	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_09135	COG1606	tRNA processing
MT476_09140	COG1691	(AIR) carboxylase
MT476_09150	COG2211	Major facilitator Superfamily
MT476_09160	COG0659	secondary active sulfate transmembrane transporter activity
MT476_09210	COG2186	Transcriptional regulator
MT476_09215	COG2807	transmembrane transport
MT476_09220	COG2258	MOSC domain
MT476_09225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MT476_09235	COG1278	Cold shock
MT476_09245	COG1278	Cold shock
MT476_09250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_09255	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MT476_09265	COG4807	Protein conserved in bacteria
MT476_09300	COG2808	Putative FMN-binding domain
MT476_09305	COG0346	lactoylglutathione lyase activity
MT476_09315	COG2304	oxidoreductase activity
MT476_09330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_09335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MT476_09340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MT476_09345	COG1733	regulation of RNA biosynthetic process
MT476_09365	COG1704	LemA family
MT476_09380	COG1012	belongs to the aldehyde dehydrogenase family
MT476_09385	COG0778	Nitroreductase
MT476_09400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MT476_09420	COG0346	lactoylglutathione lyase activity
MT476_09435	COG2814	Major facilitator Superfamily
MT476_09440	COG0583	DNA-binding transcription factor activity
MT476_09450	COG3695	enzyme binding
MT476_09455	COG1280	lysine exporter protein (LysE YggA)
MT476_09485	COG2723	6-phospho-beta-galactosidase activity
MT476_09495	COG2188	Transcriptional regulator
MT476_09520	COG0583	DNA-binding transcription factor activity
MT476_09550	COG1937	Protein conserved in bacteria
MT476_09555	COG0425	Belongs to the sulfur carrier protein TusA family
MT476_09560	COG2210	Belongs to the sulfur carrier protein TusA family
MT476_09565	COG1054	Belongs to the UPF0176 family
MT476_09575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MT476_09575	COG0425	Belongs to the sulfur carrier protein TusA family
MT476_09580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MT476_09580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_09585	COG0425	Belongs to the sulfur carrier protein TusA family
MT476_09590	COG0730	response to heat
MT476_09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MT476_09615	COG0412	Dienelactone hydrolase
MT476_09625	COG0577	efflux transmembrane transporter activity
MT476_09630	COG1136	(ABC) transporter
MT476_09635	COG2205	protein histidine kinase activity
MT476_09640	COG0745	RESPONSE REGULATOR receiver
MT476_09645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_09660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_09665	COG0477	Major facilitator Superfamily
MT476_09680	COG1073	alpha beta
MT476_09685	COG0405	Gamma-glutamyltransferase
MT476_09715	COG2824	Alkylphosphonate utilization operon protein PhnA
MT476_09720	COG1301	dicarboxylic acid transport
MT476_09730	COG0583	DNA-binding transcription factor activity
MT476_09740	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MT476_09815	COG1917	Cupin 2, conserved barrel domain protein
MT476_09815	COG2207	Transcriptional regulator
MT476_09820	COG0697	spore germination
MT476_09830	COG4989	oxidoreductase activity
MT476_09855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_09860	COG5002	protein histidine kinase activity
MT476_09885	COG5002	protein histidine kinase activity
MT476_09885	COG3850	Histidine kinase
MT476_09890	COG0577	efflux transmembrane transporter activity
MT476_09895	COG1136	(ABC) transporter
MT476_09910	COG0346	lactoylglutathione lyase activity
MT476_09930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MT476_09940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MT476_09955	COG1819	glycosyl
MT476_09975	COG3209	COG3209 Rhs family protein
MT476_09995	COG4585	Histidine kinase
MT476_10000	COG1917	Cupin 2, conserved barrel domain protein
MT476_10000	COG2207	Transcriptional regulator
MT476_10005	COG1280	lysine exporter protein (LysE YggA)
MT476_10025	COG3546	catalase activity
MT476_10050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MT476_10055	COG3773	Cell wall hydrolase
MT476_10075	COG1959	2 iron, 2 sulfur cluster binding
MT476_10080	COG1609	Transcriptional regulator
MT476_10085	COG0861	Integral membrane protein TerC family
MT476_10090	COG1396	sequence-specific DNA binding
MT476_10095	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MT476_10125	COG0681	Belongs to the peptidase S26 family
MT476_10130	COG2249	NAD(P)H dehydrogenase (quinone) activity
MT476_10150	COG3773	Cell wall hydrolase
MT476_10155	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_10160	COG4605	iron ion homeostasis
MT476_10165	COG4604	ABC transporter, ATP-binding protein
MT476_10170	COG4607	ABC-type enterochelin transport system periplasmic component
MT476_10195	COG2910	NAD(P)H-binding
MT476_10205	COG2323	membrane
MT476_10210	COG1278	Cold shock
MT476_10215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MT476_10220	COG2076	Multidrug Resistance protein
MT476_10225	COG1309	transcriptional regulator
MT476_10235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MT476_10275	COG0501	Belongs to the peptidase M48B family
MT476_10285	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MT476_10300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_10325	COG2130	NADP-dependent
MT476_10335	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MT476_10345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_10350	COG0730	response to heat
MT476_10355	COG3764	Sortase (surface protein transpeptidase)
MT476_10370	COG0531	amino acid
MT476_10375	COG1280	lysine exporter protein (LysE YggA)
MT476_10380	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_10440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MT476_10450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MT476_10470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_10475	COG1316	TRANSCRIPTIONal
MT476_10485	COG1228	amidohydrolase
MT476_10495	COG2814	Major facilitator Superfamily
MT476_10510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MT476_10520	COG1902	pentaerythritol trinitrate reductase activity
MT476_10540	COG1819	glycosyl
MT476_10575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_10580	COG0789	Transcriptional regulator
MT476_10585	COG1846	Transcriptional regulator
MT476_10590	COG0477	Major facilitator Superfamily
MT476_10605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MT476_10610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MT476_10620	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_10625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_10635	COG2746	aminoglycoside 3-N-acetyltransferase activity
MT476_10640	COG0281	malic enzyme
MT476_10660	COG1959	2 iron, 2 sulfur cluster binding
MT476_10665	COG0531	amino acid
MT476_10685	COG0640	Transcriptional regulator
MT476_10705	COG1396	sequence-specific DNA binding
MT476_10710	COG0252	asparaginase activity
MT476_10715	COG1027	Aspartate ammonia-lyase
MT476_10730	COG0740	serine-type endopeptidase activity
MT476_10745	COG2261	transglycosylase associated protein
MT476_10750	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_10780	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_10785	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_10785	COG2202	Pas domain
MT476_10805	COG0583	DNA-binding transcription factor activity
MT476_10810	COG0372	Belongs to the citrate synthase family
MT476_10820	COG1597	lipid kinase activity
MT476_10825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_10830	COG2211	Major facilitator Superfamily
MT476_10845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_10850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MT476_10860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MT476_10865	COG2318	DinB family
MT476_10870	COG2002	toxin-antitoxin pair type II binding
MT476_10875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MT476_10880	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_10880	COG4991	sh3 domain protein
MT476_10880	COG3103	Sh3 type 3 domain protein
MT476_10885	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MT476_10900	COG0778	Nitroreductase
MT476_10910	COG0640	Transcriptional regulator
MT476_10935	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MT476_10945	COG2205	protein histidine kinase activity
MT476_10960	COG1902	pentaerythritol trinitrate reductase activity
MT476_10965	COG0730	response to heat
MT476_11010	COG0733	neurotransmitter:sodium symporter activity
MT476_11020	COG0753	catalase activity
MT476_11025	COG1388	LysM domain
MT476_11025	COG0791	NLP P60 protein
MT476_11030	COG0011	TIGRFAM Protein of
MT476_11035	COG2508	Transcriptional regulator
MT476_11040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MT476_11045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MT476_11055	COG2059	Chromate
MT476_11060	COG2059	Chromate
MT476_11070	COG1605	Chorismate mutase
MT476_11070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MT476_11080	COG0287	Prephenate dehydrogenase
MT476_11090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MT476_11090	COG0723	plastoquinol--plastocyanin reductase activity
MT476_11105	COG0516	GMP reductase activity
MT476_11105	COG0517	IMP dehydrogenase activity
MT476_11120	COG1253	flavin adenine dinucleotide binding
MT476_11125	COG5577	PFAM Coat F domain
MT476_11135	COG0783	Belongs to the Dps family
MT476_11150	COG4195	phage-related replication protein
MT476_11175	COG1132	(ABC) transporter
MT476_11195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MT476_11200	COG0697	spore germination
MT476_11205	COG2244	polysaccharide biosynthetic process
MT476_11210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MT476_11215	COG0400	carboxylic ester hydrolase activity
MT476_11225	COG0586	Pfam SNARE associated Golgi protein
MT476_11230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MT476_11235	COG0778	Nitroreductase
MT476_11240	COG1388	LysM domain
MT476_11240	COG3584	3D domain protein
MT476_11245	COG0791	NLP P60 protein
MT476_11245	COG1388	LysM domain
MT476_11250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MT476_11255	COG0831	urea catabolic process
MT476_11310	COG1215	transferase activity, transferring glycosyl groups
MT476_11315	COG1233	COG1233 Phytoene dehydrogenase and related
MT476_11330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MT476_11335	COG2271	Major facilitator Superfamily
MT476_11345	COG1609	Transcriptional regulator
MT476_11355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MT476_11360	COG2404	hydrolase activity, acting on ester bonds
MT476_11365	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_11375	COG0531	amino acid
MT476_11385	COG1492	cobalamin metabolic process
MT476_11390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_11395	COG4604	ABC transporter, ATP-binding protein
MT476_11435	COG1960	acyl-CoA dehydrogenase activity
MT476_11440	COG0456	acetyltransferase
MT476_11440	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MT476_11455	COG0596	Alpha beta hydrolase
MT476_11470	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MT476_11475	COG0004	ammonium transporteR
MT476_11480	COG0347	Belongs to the P(II) protein family
MT476_11535	COG2311	Membrane
MT476_11545	COG1764	response to oxidative stress
MT476_11550	COG2814	Major facilitator Superfamily
MT476_11565	COG0508	dehydrogenase complex catalyzes the overall conversion of
MT476_11590	COG0745	RESPONSE REGULATOR receiver
MT476_11595	COG5002	protein histidine kinase activity
MT476_11605	COG1876	peptidase activity
MT476_11610	COG2323	membrane
MT476_11620	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MT476_11625	COG0598	Magnesium transport protein CorA
MT476_11630	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_11635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_11650	COG4682	membrane
MT476_11675	COG1595	DNA-templated transcription, initiation
MT476_11695	COG1131	(ABC) transporter
MT476_11700	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MT476_11720	COG1620	l-lactate permease
MT476_11725	COG0277	FAD linked oxidase domain protein
MT476_11730	COG0247	lactate metabolic process
MT476_11735	COG0277	FAD linked oxidase domain protein
MT476_11740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MT476_11745	COG0179	Fumarylacetoacetate (FAA) hydrolase
MT476_11750	COG1414	Transcriptional regulator
MT476_11755	COG2309	aminopeptidase activity
MT476_11760	COG0582	viral genome integration into host DNA
MT476_11805	COG1715	Restriction endonuclease
MT476_11860	COG0668	transmembrane transport
MT476_11875	COG0561	phosphatase activity
MT476_11880	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MT476_11885	COG0579	oxidoreductase
MT476_11915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_11925	COG0747	negative chemotaxis
MT476_11930	COG0601	transmembrane transport
MT476_11935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MT476_11945	COG4608	Belongs to the ABC transporter superfamily
MT476_11970	COG1253	flavin adenine dinucleotide binding
MT476_11975	COG0025	NhaP-type Na H and K H
MT476_12000	COG1063	alcohol dehydrogenase
MT476_12005	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_12035	COG2211	Major facilitator Superfamily
MT476_12040	COG0456	acetyltransferase
MT476_12040	COG1214	PFAM Peptidase M22, glycoprotease
MT476_12060	COG0583	DNA-binding transcription factor activity
MT476_12065	COG1979	alcohol dehydrogenase
MT476_12080	COG2391	methyltransferase activity
MT476_12105	COG2031	fatty acid transporter
MT476_12125	COG2182	Extracellular solute-binding protein
MT476_12135	COG1742	UPF0060 membrane protein
MT476_12140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_12145	COG0501	Belongs to the peptidase M48B family
MT476_12150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MT476_12175	COG2390	Transcriptional regulator
MT476_12190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MT476_12200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MT476_12220	COG3152	Membrane
MT476_12225	COG3152	Membrane
MT476_12230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_12235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MT476_12245	COG0492	ferredoxin-NADP+ reductase activity
MT476_12260	COG3152	Membrane
MT476_12265	COG1454	alcohol dehydrogenase
MT476_12275	COG3290	protein histidine kinase activity
MT476_12275	COG3829	transcription factor binding
MT476_12280	COG3835	regulator
MT476_12285	COG2610	gluconate transmembrane transporter activity
MT476_12290	COG1929	Belongs to the glycerate kinase type-1 family
MT476_12295	COG0596	Alpha beta hydrolase
MT476_12315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MT476_12330	COG1609	Transcriptional regulator
MT476_12335	COG1653	transport
MT476_12340	COG1175	transmembrane transport
MT476_12345	COG0395	ABC-type sugar transport system, permease component
MT476_12350	COG1486	melibiose metabolic process
MT476_12355	COG0488	(ABC) transporter
MT476_12375	COG5444	nuclease activity
MT476_12465	COG0579	oxidoreductase
MT476_12475	COG2318	DinB family
MT476_12505	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MT476_12530	COG3340	Belongs to the peptidase S51 family
MT476_12555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MT476_12560	COG1388	LysM domain
MT476_12560	COG3584	3D domain protein
MT476_12565	COG2814	Major facilitator Superfamily
MT476_12570	COG2323	membrane
MT476_12575	COG3279	Response regulator of the LytR AlgR family
MT476_12580	COG0427	acetyl-CoA hydrolase
MT476_12590	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_12620	COG1278	Cold shock
MT476_12625	COG0028	Belongs to the TPP enzyme family
MT476_12635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MT476_12640	COG1278	Cold shock
MT476_12645	COG2084	Dehydrogenase
MT476_12655	COG1131	(ABC) transporter
MT476_12660	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MT476_12670	COG0737	Belongs to the 5'-nucleotidase family
MT476_12675	COG2310	stress, protein
MT476_12680	COG2310	stress, protein
MT476_12685	COG2310	stress, protein
MT476_12695	COG3853	Toxic anion resistance protein (TelA)
MT476_12700	COG1349	DNA-binding transcription factor activity
MT476_12705	COG0673	inositol 2-dehydrogenase activity
MT476_12720	COG0708	Exodeoxyribonuclease III
MT476_12725	COG1846	Transcriptional regulator
MT476_12735	COG1566	PFAM secretion protein HlyD family protein
MT476_12740	COG0534	Mate efflux family protein
MT476_12755	COG5444	nuclease activity
MT476_12870	COG0584	glycerophosphoryl diester phosphodiesterase
MT476_12875	COG1515	deoxyribonuclease V activity
MT476_12880	COG0586	Pfam SNARE associated Golgi protein
MT476_12890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_12925	COG2197	response regulator
MT476_12935	COG1131	(ABC) transporter
MT476_12955	COG2610	gluconate transmembrane transporter activity
MT476_12965	COG0693	protein deglycase activity
MT476_12970	COG3835	regulator
MT476_12975	COG0277	FAD linked oxidase domain protein
MT476_12980	COG0247	lactate metabolic process
MT476_12985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_13005	COG0679	Auxin Efflux Carrier
MT476_13010	COG0583	DNA-binding transcription factor activity
MT476_13015	COG0163	prenyltransferase activity
MT476_13020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MT476_13040	COG2271	Major facilitator Superfamily
MT476_13045	COG1473	amidohydrolase
MT476_13050	COG0281	malic enzyme
MT476_13055	COG0679	Auxin Efflux Carrier
MT476_13060	COG1252	NADH dehydrogenase
MT476_13075	COG0004	ammonium transporteR
MT476_13090	COG1114	Component of the transport system for branched-chain amino acids
MT476_13100	COG1363	Peptidase, m42
MT476_13175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MT476_13180	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_13190	COG0531	amino acid
MT476_13195	COG4282	regulation of fungal-type cell wall biogenesis
MT476_13210	COG0745	RESPONSE REGULATOR receiver
MT476_13215	COG0659	secondary active sulfate transmembrane transporter activity
MT476_13220	COG0288	reversible hydration of carbon dioxide
MT476_13230	COG0789	Transcriptional regulator
MT476_13245	COG2814	Major facilitator Superfamily
MT476_13250	COG1115	amino acid carrier protein
MT476_13260	COG1295	ribonuclease BN
MT476_13275	COG1302	Protein conserved in bacteria
MT476_13290	COG2814	Major facilitator Superfamily
MT476_13305	COG1183	phosphatidylcholine synthase activity
MT476_13365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MT476_13370	COG2068	MobA-Related Protein
MT476_13375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MT476_13410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MT476_13430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MT476_13435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MT476_13465	COG0824	Thioesterase
MT476_13470	COG4841	protein insertion into membrane
MT476_13475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MT476_13480	COG1832	CoA-binding protein
MT476_13485	COG0187	DNA topoisomerase II activity
MT476_13490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MT476_13495	COG2267	carboxylic ester hydrolase activity
MT476_13500	COG1280	lysine exporter protein (LysE YggA)
MT476_13505	COG3403	YqcI/YcgG family
MT476_13515	COG1335	isochorismatase
MT476_13520	COG1247	-acetyltransferase
MT476_13530	COG0833	amino acid
MT476_13540	COG4819	ethanolamine utilization protein
MT476_13545	COG4303	Ethanolamine ammonia lyase large subunit
MT476_13550	COG4302	ethanolamine ammonia-lyase activity
MT476_13555	COG0531	amino acid
MT476_13570	COG4974	Belongs to the 'phage' integrase family
MT476_13580	COG1846	Transcriptional regulator
MT476_13585	COG1011	Hydrolase
MT476_13600	COG1914	H( )-stimulated, divalent metal cation uptake system
MT476_13615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_13625	COG3648	Uricase
MT476_13625	COG3195	allantoin biosynthetic process
MT476_13630	COG2233	PERMEase
MT476_13635	COG0204	Acyl-transferase
MT476_13645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MT476_13665	COG1227	inorganic diphosphatase activity
MT476_13670	COG2267	carboxylic ester hydrolase activity
MT476_13675	COG0129	dihydroxy-acid dehydratase activity
MT476_13680	COG2153	protein acetylation
MT476_13690	COG0697	spore germination
MT476_13710	COG2203	Gaf domain
MT476_13710	COG4585	Histidine kinase
MT476_13715	COG2197	response regulator
MT476_13720	COG0431	NADPH-dependent FMN reductase
MT476_13740	COG0183	Belongs to the thiolase family
MT476_13745	COG1268	BioY protein
MT476_13750	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_13785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MT476_13785	COG0456	acetyltransferase
MT476_13815	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MT476_13825	COG0604	alcohol dehydrogenase
MT476_13835	COG0745	RESPONSE REGULATOR receiver
MT476_13845	COG0586	Pfam SNARE associated Golgi protein
MT476_13855	COG0693	protein deglycase activity
MT476_13870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MT476_13875	COG1914	H( )-stimulated, divalent metal cation uptake system
MT476_13880	COG4336	lyase activity
MT476_13885	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MT476_13890	COG1984	allophanate hydrolase subunit 2
MT476_13895	COG0511	ligase activity, forming carbon-carbon bonds
MT476_13900	COG0439	Biotin carboxylase
MT476_13905	COG1414	Transcriptional regulator
MT476_13910	COG1587	Uroporphyrinogen-III synthase
MT476_13915	COG0791	NLP P60 protein
MT476_13915	COG3883	PFAM NLP P60 protein
MT476_13920	COG3663	DNA glycosylase
MT476_13925	COG1408	metallophosphoesterase
MT476_13935	COG0622	Phosphoesterase
MT476_13945	COG0840	transmembrane signaling receptor activity
MT476_13955	COG0277	FAD linked oxidase domain protein
MT476_13960	COG2271	Major facilitator Superfamily
MT476_13975	COG5609	conserved protein (DUF2294)
MT476_13980	COG2116	formate transmembrane transporter activity
MT476_14005	COG0076	glutamate decarboxylase activity
MT476_14050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MT476_14055	COG2720	vancomycin resistance protein
MT476_14060	COG1846	Transcriptional regulator
MT476_14065	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_14070	COG0702	epimerase
MT476_14075	COG0494	nUDIX hydrolase
MT476_14090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MT476_14140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MT476_14150	COG2015	COG2015, Alkyl sulfatase and related hydrolases
MT476_14170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MT476_14175	COG0697	spore germination
MT476_14190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MT476_14215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MT476_14220	COG0326	Molecular chaperone. Has ATPase activity
MT476_14230	COG3739	integral membrane protein
MT476_14235	COG2368	4-hydroxyphenylacetate
MT476_14245	COG3386	PFAM SMP-30 Gluconolaconase
MT476_14255	COG2267	carboxylic ester hydrolase activity
MT476_14270	COG0640	Transcriptional regulator
MT476_14275	COG3832	glyoxalase III activity
MT476_14280	COG2202	Pas domain
MT476_14280	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_14290	COG2409	Drug exporters of the RND superfamily
MT476_14290	COG1033	growth of symbiont in host cell
MT476_14295	COG1846	Transcriptional regulator
MT476_14300	COG2814	Major facilitator Superfamily
MT476_14305	COG0531	amino acid
MT476_14315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MT476_14320	COG3119	arylsulfatase activity
MT476_14330	COG3773	Cell wall hydrolase
MT476_14335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MT476_14345	COG3977	Valine--pyruvate aminotransferase
MT476_14365	COG1181	Belongs to the D-alanine--D-alanine ligase family
MT476_14370	COG0738	Major facilitator superfamily
MT476_14375	COG1979	alcohol dehydrogenase
MT476_14390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_14395	COG0833	amino acid
MT476_14405	COG1509	lysine 2,3-aminomutase activity
MT476_14425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MT476_14430	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MT476_14435	COG0183	Belongs to the thiolase family
MT476_14440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MT476_14445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MT476_14455	COG1141	Ferredoxin
MT476_14465	COG3321	synthase
MT476_14465	COG0604	alcohol dehydrogenase
MT476_14465	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_14470	COG1024	Enoyl-CoA hydratase
MT476_14475	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_14480	COG1960	acyl-CoA dehydrogenase activity
MT476_14485	COG2045	Belongs to the ComB family
MT476_14500	COG1024	Enoyl-CoA hydratase
MT476_14505	COG1250	3-hydroxyacyl-CoA dehydrogenase
MT476_14515	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_14520	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_14535	COG4191	Histidine kinase
MT476_14545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MT476_14555	COG0019	diaminopimelate decarboxylase activity
MT476_14560	COG1301	dicarboxylic acid transport
MT476_14570	COG0583	DNA-binding transcription factor activity
MT476_14575	COG4122	O-methyltransferase activity
MT476_14590	COG2195	Cleaves the N-terminal amino acid of tripeptides
MT476_14595	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_14600	COG2610	gluconate transmembrane transporter activity
MT476_14610	COG2851	Citrate transporter
MT476_14615	COG4565	transcriptional regulatory protein
MT476_14620	COG3290	protein histidine kinase activity
MT476_14625	COG0300	oxidoreductase activity
MT476_14635	COG0778	Nitroreductase
MT476_14670	COG5002	protein histidine kinase activity
MT476_14680	COG3757	hydrolase, family 25
MT476_14680	COG3409	Peptidoglycan-binding domain 1 protein
MT476_14690	COG0114	fumarate hydratase activity
MT476_14705	COG2176	DNA-directed DNA polymerase activity
MT476_14715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MT476_14725	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_14735	COG0346	lactoylglutathione lyase activity
MT476_14775	COG1295	ribonuclease BN
MT476_14785	COG1834	amidinotransferase
MT476_14790	COG2409	Drug exporters of the RND superfamily
MT476_14805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MT476_14820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MT476_14825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MT476_14830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MT476_14835	COG5002	protein histidine kinase activity
MT476_14855	COG1388	LysM domain
MT476_14855	COG3584	3D domain protein
MT476_14865	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MT476_14880	COG1846	Transcriptional regulator
MT476_14885	COG1764	response to oxidative stress
MT476_14900	COG1595	DNA-templated transcription, initiation
MT476_14910	COG1131	(ABC) transporter
MT476_14915	COG1725	Transcriptional regulator
MT476_14920	COG0583	DNA-binding transcription factor activity
MT476_14930	COG2814	Major facilitator Superfamily
MT476_14950	COG1575	Belongs to the MenA family. Type 1 subfamily
MT476_14970	COG1012	belongs to the aldehyde dehydrogenase family
MT476_14985	COG0514	ATP-dependent DNA helicase (RecQ)
MT476_15025	COG2720	vancomycin resistance protein
MT476_15030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MT476_15035	COG1454	alcohol dehydrogenase
MT476_15045	COG1012	belongs to the aldehyde dehydrogenase family
MT476_15050	COG1027	Aspartate ammonia-lyase
MT476_15055	COG1012	belongs to the aldehyde dehydrogenase family
MT476_15060	COG4948	Mandelate Racemase Muconate Lactonizing
MT476_15075	COG2204	response regulator
MT476_15080	COG5002	protein histidine kinase activity
MT476_15090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_15100	COG0697	spore germination
MT476_15110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MT476_15115	COG1757	Na H antiporter
MT476_15135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MT476_15170	COG0446	pyridine nucleotide-disulphide oxidoreductase
MT476_15180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MT476_15180	COG0551	DNA topoisomerase type I activity
MT476_15200	COG1533	DNA photolyase activity
MT476_15210	COG1609	Transcriptional regulator
MT476_15215	COG1757	Na H antiporter
MT476_15220	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MT476_15225	COG1131	(ABC) transporter
MT476_15240	COG0531	amino acid
MT476_15245	COG0697	spore germination
MT476_15250	COG0488	(ABC) transporter
MT476_15255	COG0697	spore germination
MT476_15260	COG2207	Transcriptional regulator
MT476_15260	COG0662	Cupin 2, conserved barrel domain protein
MT476_15270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_15275	COG2223	nitrite transmembrane transporter activity
MT476_15280	COG1254	Belongs to the acylphosphatase family
MT476_15285	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_15290	COG1404	Belongs to the peptidase S8 family
MT476_15300	COG1098	S1 RNA binding domain
MT476_15305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MT476_15310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MT476_15315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MT476_15320	COG1335	isochorismatase
MT476_15325	COG0494	nUDIX hydrolase
MT476_15340	COG1408	metallophosphoesterase
MT476_15375	COG1132	(ABC) transporter
MT476_15435	COG0438	transferase activity, transferring glycosyl groups
MT476_15440	COG1216	Glycosyl transferase, family 2
MT476_15440	COG1442	glycosyl transferase family 8
MT476_15450	COG0438	transferase activity, transferring glycosyl groups
MT476_15455	COG1396	sequence-specific DNA binding
MT476_15460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MT476_15465	COG0110	maltose O-acetyltransferase activity
MT476_15470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MT476_15480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MT476_15490	COG1215	transferase activity, transferring glycosyl groups
MT476_15495	COG0438	transferase activity, transferring glycosyl groups
MT476_15500	COG0438	transferase activity, transferring glycosyl groups
MT476_15505	COG1086	Polysaccharide biosynthesis protein
MT476_15515	COG0489	protein tyrosine kinase activity
MT476_15520	COG3944	biosynthesis protein
MT476_15525	COG3420	alginic acid biosynthetic process
MT476_15525	COG5434	Belongs to the glycosyl hydrolase 28 family
MT476_15555	COG3541	Predicted nucleotidyltransferase
MT476_15585	COG1279	arginine transmembrane transporter activity
MT476_15590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MT476_15620	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MT476_15630	COG1378	Sugar-specific transcriptional regulator TrmB
MT476_15650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MT476_15650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MT476_15660	COG1657	PFAM Prenyltransferase squalene oxidase
MT476_15675	COG1119	ATPase activity
MT476_15680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_15685	COG1994	Peptidase M50
MT476_15690	COG2207	Transcriptional regulator
MT476_15700	COG0697	spore germination
MT476_15705	COG4548	von Willebrand factor, type A
MT476_15710	COG0714	Associated with various cellular activities
MT476_15715	COG4873	Protein conserved in bacteria
MT476_15720	COG1595	DNA-templated transcription, initiation
MT476_15745	COG3871	stress protein (general stress protein 26)
MT476_15760	COG2814	Major facilitator Superfamily
MT476_15770	COG0454	-acetyltransferase
MT476_15780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MT476_15785	COG2094	Belongs to the DNA glycosylase MPG family
MT476_15790	COG1082	Xylose isomerase domain protein TIM barrel
MT476_15795	COG0673	inositol 2-dehydrogenase activity
MT476_15815	COG3773	Cell wall hydrolase
MT476_15820	COG0733	neurotransmitter:sodium symporter activity
MT476_15835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MT476_15840	COG1012	belongs to the aldehyde dehydrogenase family
MT476_15845	COG0640	Transcriptional regulator
MT476_15850	COG0300	oxidoreductase activity
MT476_15860	COG1233	COG1233 Phytoene dehydrogenase and related
MT476_15865	COG2032	superoxide dismutase activity
MT476_15875	COG0527	aspartate kinase activity
MT476_15880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MT476_15880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MT476_15880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MT476_15885	COG1105	Belongs to the carbohydrate kinase PfkB family
MT476_15890	COG1349	DNA-binding transcription factor activity
MT476_15905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_15930	COG0745	RESPONSE REGULATOR receiver
MT476_15945	COG4208	sulfate ABC transporter
MT476_15955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
MT476_15965	COG5583	Uncharacterized small protein (DUF2292)
MT476_15975	COG0745	RESPONSE REGULATOR receiver
MT476_15980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MT476_15985	COG2246	polysaccharide biosynthetic process
MT476_15990	COG0463	Glycosyl transferase, family 2
MT476_15995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MT476_16005	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_16010	COG1346	cytolysis
MT476_16015	COG1380	Effector of murein hydrolase LrgA
MT476_16020	COG1846	Transcriptional regulator
MT476_16035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MT476_16050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MT476_16070	COG0493	'glutamate synthase
MT476_16075	COG0069	glutamate synthase activity
MT476_16075	COG0067	glutamate synthase
MT476_16075	COG0070	glutamate synthase
MT476_16080	COG0583	DNA-binding transcription factor activity
MT476_16115	COG0789	Transcriptional regulator
MT476_16130	COG4195	phage-related replication protein
MT476_16135	COG0109	protoheme IX farnesyltransferase activity
MT476_16140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MT476_16155	COG3428	Bacterial PH domain
MT476_16160	COG3402	PFAM membrane-flanked domain
MT476_16165	COG0281	malic enzyme
MT476_16170	COG1611	Belongs to the LOG family
MT476_16210	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_16220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_16225	COG0196	riboflavin kinase activity
MT476_16230	COG1126	abc transporter atp-binding protein
MT476_16235	COG0765	amino acid transport
MT476_16240	COG0765	amino acid transport
MT476_16245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MT476_16250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MT476_16255	COG0456	acetyltransferase
MT476_16265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_16270	COG0561	phosphatase activity
MT476_16275	COG3493	citrate carrier protein
MT476_16280	COG0281	malic enzyme
MT476_16290	COG3104	oligopeptide transport
MT476_16295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MT476_16300	COG5002	protein histidine kinase activity
MT476_16305	COG0745	RESPONSE REGULATOR receiver
MT476_16315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MT476_16320	COG3594	Acyltransferase
MT476_16325	COG0833	amino acid
MT476_16335	COG1757	Na H antiporter
MT476_16340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MT476_16345	COG3361	conserved protein (COG2071)
MT476_16360	COG1360	Flagellar Motor Protein
MT476_16365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MT476_16380	COG2112	serine threonine protein kinase
MT476_16385	COG2124	cytochrome p450
MT476_16390	COG1012	belongs to the aldehyde dehydrogenase family
MT476_16395	COG1523	belongs to the glycosyl hydrolase 13 family
MT476_16400	COG1823	symporter activity
MT476_16410	COG5002	protein histidine kinase activity
MT476_16415	COG2234	aminopeptidase activity
MT476_16445	COG3853	Toxic anion resistance protein (TelA)
MT476_16455	COG1368	sulfuric ester hydrolase activity
MT476_16485	COG0534	Mate efflux family protein
MT476_16490	COG2002	toxin-antitoxin pair type II binding
MT476_16510	COG1595	DNA-templated transcription, initiation
MT476_16515	COG3011	Protein conserved in bacteria
MT476_16525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MT476_16530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MT476_16535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MT476_16545	COG0322	excinuclease ABC activity
MT476_16550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MT476_16570	COG2962	Rard protein
MT476_16575	COG2096	Adenosyltransferase
MT476_16585	COG0406	alpha-ribazole phosphatase activity
MT476_16590	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MT476_16595	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
MT476_16605	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MT476_16615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MT476_16620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MT476_16630	COG2521	methyltransferase
MT476_16630	COG2136	Putative SAM-dependent methyltransferase
MT476_16640	COG0726	polysaccharide deacetylase
MT476_16645	COG1413	lyase activity
MT476_16650	COG0488	(ABC) transporter
MT476_16655	COG1418	mRNA catabolic process
MT476_16660	COG0386	Belongs to the glutathione peroxidase family
MT476_16675	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MT476_16725	COG1876	peptidase activity
MT476_16730	COG0561	phosphatase activity
MT476_16745	COG5566	PFAM Mor transcription activator
MT476_16755	COG2226	methyltransferase
MT476_16775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MT476_16775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MT476_16780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MT476_16780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MT476_16785	COG1733	regulation of RNA biosynthetic process
MT476_16790	COG2814	Major facilitator Superfamily
MT476_16795	COG0473	3-isopropylmalate dehydrogenase activity
MT476_16800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MT476_16820	COG2323	membrane
MT476_16825	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MT476_16830	COG2050	protein possibly involved in aromatic compounds catabolism
MT476_16835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MT476_16840	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MT476_16845	COG0640	Transcriptional regulator
MT476_16885	COG2271	Major facilitator Superfamily
MT476_16890	COG1388	LysM domain
MT476_16900	COG2217	Heavy metal translocating P-type atpase
MT476_16905	COG2608	mercury ion transmembrane transporter activity
MT476_16910	COG1937	Protein conserved in bacteria
MT476_16920	COG5002	protein histidine kinase activity
MT476_16925	COG0589	response to stress
MT476_16945	COG2211	Major facilitator Superfamily
MT476_16960	COG2721	sulfolactate sulfo-lyase activity
MT476_16965	COG0246	Mannitol dehydrogenase
MT476_16970	COG1609	Transcriptional regulator
MT476_16975	COG2211	Major facilitator Superfamily
MT476_16980	COG1904	glucuronate isomerase
MT476_16985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MT476_16990	COG0628	permease
MT476_17030	COG1846	Transcriptional regulator
MT476_17045	COG3284	Transcriptional regulator
MT476_17050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MT476_17055	COG0508	dehydrogenase complex catalyzes the overall conversion of
MT476_17060	COG0022	dehydrogenase e1 component
MT476_17065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MT476_17075	COG2252	PERMEase
MT476_17085	COG2072	flavoprotein involved in K transport
MT476_17090	COG1612	heme a metabolic process
MT476_17095	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_17100	COG0589	response to stress
MT476_17105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MT476_17110	COG1845	cytochrome c oxidase, subunit III
MT476_17115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MT476_17140	COG2851	Citrate transporter
MT476_17145	COG3290	protein histidine kinase activity
MT476_17145	COG3829	transcription factor binding
MT476_17155	COG0517	IMP dehydrogenase activity
MT476_17190	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_17205	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MT476_17215	COG1454	alcohol dehydrogenase
MT476_17220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MT476_17235	COG1012	belongs to the aldehyde dehydrogenase family
MT476_17255	COG0477	Major facilitator Superfamily
MT476_17270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MT476_17275	COG4608	Belongs to the ABC transporter superfamily
MT476_17280	COG0444	Belongs to the ABC transporter superfamily
MT476_17285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MT476_17290	COG0601	transmembrane transport
MT476_17300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MT476_17305	COG3848	Pyruvate phosphate dikinase
MT476_17305	COG0574	Belongs to the PEP-utilizing enzyme family
MT476_17335	COG4282	regulation of fungal-type cell wall biogenesis
MT476_17345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MT476_17460	COG1027	Aspartate ammonia-lyase
MT476_17480	COG1994	Peptidase M50
MT476_17500	COG1266	CAAX protease self-immunity
MT476_17570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MT476_17600	COG2376	Dihydroxyacetone kinase
MT476_17610	COG2207	Transcriptional regulator
MT476_17620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_17625	COG1733	regulation of RNA biosynthetic process
MT476_17630	COG0697	spore germination
MT476_17635	COG5553	Cysteine dioxygenase type I
MT476_17640	COG0346	lactoylglutathione lyase activity
MT476_17645	COG0640	Transcriptional regulator
MT476_17650	COG0640	Transcriptional regulator
MT476_17655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MT476_17670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_17680	COG2226	methyltransferase
MT476_17710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MT476_17715	COG1376	ErfK ybiS ycfS ynhG family protein
MT476_17720	COG1388	LysM domain
MT476_17720	COG3858	chitin binding
MT476_17725	COG2172	sigma factor antagonist activity
MT476_17775	COG0028	Belongs to the TPP enzyme family
MT476_17785	COG1278	Cold shock
MT476_17820	COG2076	Multidrug Resistance protein
MT476_17870	COG3813	Protein conserved in bacteria
MT476_17875	COG1522	sequence-specific DNA binding
MT476_17885	COG1940	carbohydrate kinase activity
MT476_17895	COG2723	6-phospho-beta-galactosidase activity
MT476_17905	COG1447	Phosphotransferase system cellobiose-specific component IIA
MT476_17910	COG2188	Transcriptional regulator
MT476_17915	COG0861	Integral membrane protein TerC family
MT476_17920	COG1309	transcriptional regulator
MT476_17950	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_17955	COG0387	Pfam Sodium calcium exchanger
MT476_17990	COG0697	spore germination
MT476_18000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MT476_18015	COG0586	Pfam SNARE associated Golgi protein
MT476_18035	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_18055	COG0596	Alpha beta hydrolase
MT476_18055	COG2945	thiolester hydrolase activity
MT476_18060	COG0583	DNA-binding transcription factor activity
MT476_18090	COG2318	DinB family
MT476_18115	COG1388	LysM domain
MT476_18115	COG0791	NLP P60 protein
MT476_18130	COG0494	nUDIX hydrolase
MT476_18135	COG0698	ribose 5-phosphate isomerase
MT476_18150	COG2186	Transcriptional regulator
MT476_18155	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_18160	COG3958	Transketolase
MT476_18165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MT476_18170	COG2814	Major facilitator Superfamily
MT476_18175	COG1309	transcriptional regulator
MT476_18180	COG0574	Belongs to the PEP-utilizing enzyme family
MT476_18180	COG3848	Pyruvate phosphate dikinase
MT476_18230	COG0640	Transcriptional regulator
MT476_18235	COG0456	acetyltransferase
MT476_18240	COG1846	Transcriptional regulator
MT476_18245	COG2364	Membrane
MT476_18260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_18290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MT476_18295	COG1288	antiporter activity
MT476_18310	COG1846	Transcriptional regulator
MT476_18315	COG0010	Belongs to the arginase family
MT476_18320	COG1228	amidohydrolase
MT476_18330	COG2986	histidine ammonia-lyase
MT476_18335	COG0656	L-ascorbic acid biosynthetic process
MT476_18345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MT476_18355	COG0024	Methionine aminopeptidase
MT476_18360	COG1621	beta-fructofuranosidase activity
MT476_18370	COG3716	PTS system mannose fructose sorbose family IID component
MT476_18375	COG3715	PTS system
MT476_18380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_18385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MT476_18390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MT476_18390	COG3933	PFAM sigma-54 factor interaction domain-containing protein
MT476_18395	COG1621	beta-fructofuranosidase activity
MT476_18400	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MT476_18415	COG1609	Transcriptional regulator
MT476_18430	COG1113	amino acid transport
MT476_18460	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MT476_18475	COG1113	amino acid transport
MT476_18480	COG1280	lysine exporter protein (LysE YggA)
MT476_18490	COG1012	belongs to the aldehyde dehydrogenase family
MT476_18505	COG2814	Major facilitator Superfamily
MT476_18515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MT476_18520	COG0156	8-amino-7-oxononanoate synthase activity
MT476_18525	COG0477	Major facilitator Superfamily
MT476_18530	COG2193	ferroxidase activity
MT476_18535	COG1621	beta-fructofuranosidase activity
MT476_18540	COG1621	beta-fructofuranosidase activity
MT476_18545	COG0405	Gamma-glutamyltransferase
MT476_18550	COG1011	Hydrolase
MT476_18560	COG0531	amino acid
MT476_18570	COG2208	phosphoserine phosphatase activity
MT476_18575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MT476_18580	COG0784	Response regulator, receiver
MT476_18580	COG2205	protein histidine kinase activity
MT476_18585	COG0469	pyruvate kinase activity
MT476_18600	COG3448	diguanylate cyclase activity
MT476_18600	COG4175	Glycine betaine
MT476_18610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MT476_18620	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MT476_18625	COG1733	regulation of RNA biosynthetic process
MT476_18630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MT476_18650	COG2814	Major facilitator Superfamily
MT476_18660	COG0492	ferredoxin-NADP+ reductase activity
MT476_18665	COG1120	ATPase activity
MT476_18670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MT476_18675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_18680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_18700	COG1846	Transcriptional regulator
MT476_18705	COG2814	Major facilitator Superfamily
MT476_18710	COG1566	PFAM secretion protein HlyD family protein
MT476_18715	COG1846	Transcriptional regulator
MT476_18725	COG1404	Belongs to the peptidase S8 family
MT476_18730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MT476_18740	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_18750	COG2814	Major facilitator Superfamily
MT476_18765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MT476_18770	COG1819	glycosyl
MT476_18775	COG1388	LysM domain
MT476_18775	COG0791	NLP P60 protein
MT476_18790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MT476_18800	COG2205	protein histidine kinase activity
MT476_18805	COG3239	Fatty acid desaturase
MT476_18810	COG4585	Histidine kinase
MT476_18815	COG2197	response regulator
MT476_18845	COG1120	ATPase activity
MT476_18850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_18855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_18860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MT476_18865	COG0701	Predicted permease
MT476_18870	COG3689	TIGRFAM TIGR03943 family protein
MT476_18875	COG3300	MHYT domain
MT476_18875	COG5001	Diguanylate cyclase
MT476_18880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_18895	COG4608	Belongs to the ABC transporter superfamily
MT476_18900	COG0791	NLP P60 protein
MT476_18905	COG1619	proteins homologs of microcin C7 resistance protein MccF
MT476_18910	COG4166	transmembrane transport
MT476_18915	COG0444	Belongs to the ABC transporter superfamily
MT476_18920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MT476_18925	COG0601	transmembrane transport
MT476_18930	COG2362	D-Aminopeptidase
MT476_18935	COG2233	PERMEase
MT476_18945	COG2814	Major facilitator Superfamily
MT476_18970	COG0328	RNA-DNA hybrid ribonuclease activity
MT476_18975	COG0328	RNA-DNA hybrid ribonuclease activity
MT476_19000	COG3541	Predicted nucleotidyltransferase
MT476_19005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MT476_19015	COG1755	Isoprenylcysteine carboxyl methyltransferase
MT476_19020	COG3424	synthase
MT476_19030	COG1012	belongs to the aldehyde dehydrogenase family
MT476_19035	COG0583	DNA-binding transcription factor activity
MT476_19040	COG2233	PERMEase
MT476_19045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MT476_19050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MT476_19055	COG1199	ATP-dependent helicase activity
MT476_19065	COG3842	ATPase activity
MT476_19075	COG1175	transmembrane transport
MT476_19090	COG0116	Belongs to the methyltransferase superfamily
MT476_19095	COG0366	Alpha amylase catalytic
MT476_19100	COG2197	response regulator
MT476_19130	COG3599	regulation of cell shape
MT476_19135	COG4474	Belongs to the UPF0398 family
MT476_19145	COG3359	exonuclease
MT476_19150	COG1205	dead DEAH box helicase
MT476_19150	COG1111	helicase
MT476_19160	COG3706	GGDEF domain
MT476_19190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MT476_19205	COG0626	cystathionine gamma-synthase activity
MT476_19210	COG0626	cystathionine gamma-synthase activity
MT476_19225	COG5337	Spore coat protein CotH
MT476_19270	COG3331	DNA recombination
MT476_19275	COG4499	WXG100 protein secretion system (Wss), protein YukC
MT476_19275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MT476_19285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MT476_19290	COG3935	DnaD domain protein
MT476_19295	COG0017	Asparaginyl-tRNA synthetase
MT476_19300	COG0436	Aminotransferase
MT476_19320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MT476_19320	COG1199	ATP-dependent helicase activity
MT476_19325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MT476_19330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MT476_19340	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MT476_19340	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MT476_19345	COG0617	tRNA 3'-terminal CCA addition
MT476_19350	COG0438	transferase activity, transferring glycosyl groups
MT476_19355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MT476_19360	COG1803	Methylglyoxal synthase
MT476_19365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MT476_19370	COG1694	Mazg nucleotide pyrophosphohydrolase
MT476_19375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_19380	COG2738	Putative neutral zinc metallopeptidase
MT476_19390	COG2340	Cysteine-rich secretory protein family
MT476_19395	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MT476_19405	COG3336	cytochrome c oxidase
MT476_19430	COG0109	protoheme IX farnesyltransferase activity
MT476_19435	COG1612	heme a metabolic process
MT476_19440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MT476_19445	COG0772	Belongs to the SEDS family
MT476_19450	COG4838	Belongs to the UPF0358 family
MT476_19455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MT476_19460	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MT476_19475	COG4896	Protein conserved in bacteria
MT476_19490	COG1217	gtp-binding protein TYPA
MT476_19500	COG0483	inositol monophosphate 1-phosphatase activity
MT476_19510	COG4493	Belongs to the UPF0637 family
MT476_19520	COG4476	Belongs to the UPF0223 family
MT476_19525	COG1982	Orn Lys Arg decarboxylase major
MT476_19535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MT476_19550	COG0508	dehydrogenase complex catalyzes the overall conversion of
MT476_19555	COG0022	dehydrogenase e1 component
MT476_19580	COG0561	phosphatase activity
MT476_19585	COG5503	Protein of unknown function (DUF1447)
MT476_19590	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MT476_19595	COG0569	domain protein
MT476_19600	COG1132	(ABC) transporter
MT476_19605	COG1132	(ABC) transporter
MT476_19610	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MT476_19615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MT476_19620	COG0450	alkyl hydroperoxide reductase
MT476_19625	COG0668	transmembrane transport
MT476_19635	COG1473	amidohydrolase
MT476_19640	COG2171	N-acyltransferase activity
MT476_19645	COG0583	DNA-binding transcription factor activity
MT476_19650	COG0517	IMP dehydrogenase activity
MT476_19655	COG4703	Protein of unknown function (DUF1797)
MT476_19670	COG2200	EAL domain
MT476_19675	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_19680	COG1408	metallophosphoesterase
MT476_19695	COG0248	Ppx GppA phosphatase
MT476_19700	COG1376	ErfK ybiS ycfS ynhG family protein
MT476_19710	COG0784	Response regulator, receiver
MT476_19710	COG0835	chemotaxis
MT476_19730	COG0436	Aminotransferase
MT476_19735	COG0778	Nitroreductase
MT476_19740	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_19745	COG0456	acetyltransferase
MT476_19755	COG0583	DNA-binding transcription factor activity
MT476_19765	COG1346	cytolysis
MT476_19780	COG2190	(PTS) system
MT476_19780	COG1263	PTS System
MT476_19780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_19785	COG3711	transcriptional antiterminator
MT476_19795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MT476_19805	COG0307	riboflavin synthase, alpha
MT476_19810	COG3949	Membrane
MT476_19815	COG0646	methionine synthase
MT476_19815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MT476_19820	COG0646	methionine synthase
MT476_19820	COG1410	methionine synthase
MT476_19860	COG3773	Cell wall hydrolase
MT476_19880	COG4873	Protein conserved in bacteria
MT476_19890	COG0702	epimerase
MT476_19895	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MT476_19905	COG0720	synthase
MT476_19910	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MT476_19930	COG0697	spore germination
MT476_19935	COG0300	oxidoreductase activity
MT476_19950	COG1757	Na H antiporter
MT476_19955	COG0542	response to heat
MT476_19965	COG4191	Histidine kinase
MT476_19975	COG1846	Transcriptional regulator
MT476_20005	COG1172	Belongs to the binding-protein-dependent transport system permease family
MT476_20010	COG1129	ABC transporter
MT476_20020	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MT476_20025	COG0235	Class ii aldolase
MT476_20030	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MT476_20035	COG1850	ribulose-bisphosphate carboxylase activity
MT476_20040	COG0436	Aminotransferase
MT476_20045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MT476_20050	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MT476_20055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MT476_20065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MT476_20070	COG5002	protein histidine kinase activity
MT476_20075	COG1556	Lactate utilization protein
MT476_20080	COG1139	Iron-sulfur cluster binding protein
MT476_20085	COG0247	lactate metabolic process
MT476_20095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MT476_20100	COG2186	Transcriptional regulator
MT476_20120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MT476_20125	COG3243	poly(R)-hydroxyalkanoic acid synthase
MT476_20155	COG1191	sigma factor activity
MT476_20160	COG0861	Integral membrane protein TerC family
MT476_20165	COG2205	protein histidine kinase activity
MT476_20165	COG0784	Response regulator, receiver
MT476_20170	COG3279	Response regulator of the LytR AlgR family
MT476_20175	COG1785	Belongs to the alkaline phosphatase family
MT476_20195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MT476_20205	COG1846	Transcriptional regulator
MT476_20210	COG0789	Transcriptional regulator
MT476_20220	COG1668	transmembrane transport
MT476_20225	COG4555	ABC transporter
MT476_20230	COG3279	Response regulator of the LytR AlgR family
MT476_20240	COG2252	PERMEase
MT476_20255	COG0456	acetyltransferase
MT476_20255	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MT476_20270	COG4187	Peptidase family M20/M25/M40
MT476_20280	COG1473	amidohydrolase
MT476_20285	COG0456	acetyltransferase
MT476_20290	COG0840	transmembrane signaling receptor activity
MT476_20320	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MT476_20320	COG2105	PFAM AIG2 family protein
MT476_20325	COG0346	lactoylglutathione lyase activity
MT476_20335	COG0789	Transcriptional regulator
MT476_20340	COG1253	flavin adenine dinucleotide binding
MT476_20345	COG1131	(ABC) transporter
MT476_20380	COG1811	Na channel or pump
MT476_20385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_20385	COG1263	PTS System
MT476_20385	COG2190	(PTS) system
MT476_20390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MT476_20395	COG0363	glucosamine-6-phosphate deaminase activity
MT476_20400	COG2188	Transcriptional regulator
MT476_20405	COG4821	SIS domain
MT476_20425	COG1404	Belongs to the peptidase S8 family
MT476_20430	COG0598	Magnesium transport protein CorA
MT476_20440	COG1316	TRANSCRIPTIONal
MT476_20455	COG0534	Mate efflux family protein
MT476_20470	COG4975	Glucose uptake
MT476_20475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MT476_20485	COG2116	formate transmembrane transporter activity
MT476_20495	COG2146	nitrite reductase [NAD(P)H] activity
MT476_20500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MT476_20530	COG2084	Dehydrogenase
MT476_20540	COG0069	glutamate synthase activity
MT476_20545	COG0028	Belongs to the TPP enzyme family
MT476_20555	COG4464	protein tyrosine phosphatase activity
MT476_20575	COG1134	teichoic acid transport
MT476_20580	COG1682	transport, permease protein
MT476_20595	COG1442	glycosyl transferase family 8
MT476_20595	COG1216	Glycosyl transferase, family 2
MT476_20610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MT476_20615	COG0489	protein tyrosine kinase activity
MT476_20620	COG3944	biosynthesis protein
MT476_20630	COG4464	protein tyrosine phosphatase activity
MT476_20635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MT476_20640	COG0463	Glycosyl transferase, family 2
MT476_20640	COG1216	Glycosyl transferase, family 2
MT476_20665	COG1215	transferase activity, transferring glycosyl groups
MT476_20670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MT476_20680	COG2247	cell wall binding repeat
MT476_20680	COG2385	sporulation resulting in formation of a cellular spore
MT476_20685	COG1396	sequence-specific DNA binding
MT476_20695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MT476_20715	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MT476_20745	COG0531	amino acid
MT476_20750	COG3300	MHYT domain
MT476_20750	COG5001	Diguanylate cyclase
MT476_20760	COG3634	alkyl hydroperoxide reductase activity
MT476_20765	COG0302	gtp cyclohydrolase
MT476_20770	COG3300	MHYT domain
MT476_20770	COG5001	Diguanylate cyclase
MT476_20800	COG5658	integral membrane protein
MT476_20805	COG0640	Transcriptional regulator
MT476_20820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MT476_20825	COG0477	Major facilitator Superfamily
MT476_20835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MT476_20855	COG4948	Mandelate Racemase Muconate Lactonizing
MT476_20860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MT476_20880	COG0656	L-ascorbic acid biosynthetic process
MT476_20885	COG2385	sporulation resulting in formation of a cellular spore
MT476_20895	COG1388	LysM domain
MT476_20895	COG0791	NLP P60 protein
MT476_20910	COG0784	Response regulator, receiver
MT476_20915	COG4191	Histidine kinase
MT476_20925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MT476_20935	COG0385	Bile acid
MT476_20950	COG1733	regulation of RNA biosynthetic process
MT476_20960	COG2199	diguanylate cyclase activity
MT476_20960	COG2200	EAL domain
MT476_21010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MT476_21020	COG0154	amidase activity
MT476_21030	COG2323	membrane
MT476_21040	COG0667	Aldo Keto reductase
MT476_21050	COG0583	DNA-binding transcription factor activity
MT476_21065	COG3773	Cell wall hydrolase
MT476_21065	COG3409	Peptidoglycan-binding domain 1 protein
MT476_21080	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MT476_21090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MT476_21095	COG2971	BadF BadG BcrA BcrD
MT476_21105	COG1447	Phosphotransferase system cellobiose-specific component IIA
MT476_21115	COG1486	melibiose metabolic process
MT476_21135	COG1737	Transcriptional regulator
MT476_21140	COG1649	PFAM Uncharacterised BCR, COG1649
MT476_21225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MT476_21230	COG2203	Gaf domain
MT476_21230	COG3706	GGDEF domain
MT476_21230	COG4251	negative regulation of phosphorylation
MT476_21230	COG5001	Diguanylate cyclase
MT476_21250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MT476_21255	COG0450	alkyl hydroperoxide reductase
MT476_21260	COG0673	inositol 2-dehydrogenase activity
MT476_21265	COG2910	NAD(P)H-binding
MT476_21270	COG1278	Cold shock
MT476_21275	COG1131	(ABC) transporter
MT476_21285	COG0402	S-adenosylhomocysteine deaminase activity
MT476_21290	COG0531	amino acid
MT476_21305	COG0439	Biotin carboxylase
MT476_21330	COG0628	permease
MT476_21335	COG0778	Nitroreductase
MT476_21350	COG1272	protein, Hemolysin III
MT476_21355	COG1914	H( )-stimulated, divalent metal cation uptake system
MT476_21360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MT476_21365	COG1984	allophanate hydrolase subunit 2
MT476_21370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MT476_21375	COG2188	Transcriptional regulator
MT476_21380	COG0366	Alpha amylase catalytic
MT476_21385	COG1263	PTS System
MT476_21385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_21395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MT476_21400	COG2252	PERMEase
MT476_21405	COG0402	S-adenosylhomocysteine deaminase activity
MT476_21420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MT476_21430	COG2267	carboxylic ester hydrolase activity
MT476_21440	COG5002	protein histidine kinase activity
MT476_21445	COG0745	RESPONSE REGULATOR receiver
MT476_21490	COG1653	transport
MT476_21495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MT476_21500	COG1388	LysM domain
MT476_21500	COG3584	3D domain protein
MT476_21505	COG1879	ABC-type sugar transport system periplasmic component
MT476_21510	COG1172	Belongs to the binding-protein-dependent transport system permease family
MT476_21515	COG1129	ABC transporter
MT476_21525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MT476_21530	COG1609	Transcriptional regulator
MT476_21545	COG0655	NAD(P)H dehydrogenase (quinone) activity
MT476_21550	COG2814	Major facilitator Superfamily
MT476_21555	COG1566	PFAM secretion protein HlyD family protein
MT476_21560	COG1846	Transcriptional regulator
MT476_21565	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MT476_21570	COG0656	L-ascorbic acid biosynthetic process
MT476_21575	COG1414	Transcriptional regulator
MT476_21585	COG3162	membrane
MT476_21590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MT476_21600	COG1132	(ABC) transporter
MT476_21605	COG1132	(ABC) transporter
MT476_21610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MT476_21610	COG0604	alcohol dehydrogenase
MT476_21610	COG4221	oxidoreductase activity
MT476_21610	COG3321	synthase
MT476_21615	COG1733	regulation of RNA biosynthetic process
MT476_21620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MT476_21625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MT476_21630	COG1511	domain protein
MT476_21665	COG1733	regulation of RNA biosynthetic process
MT476_21670	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MT476_21675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MT476_21685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MT476_21690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MT476_21695	COG1116	anion transmembrane transporter activity
MT476_21700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MT476_21705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MT476_21715	COG1263	PTS System
MT476_21715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MT476_21720	COG1737	Transcriptional regulator
MT476_21750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_21755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MT476_21760	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MT476_21770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_21785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MT476_21790	COG0531	amino acid
MT476_21805	COG1012	belongs to the aldehyde dehydrogenase family
MT476_21810	COG1309	transcriptional regulator
MT476_21815	COG2113	Glycine betaine
MT476_21820	COG0517	IMP dehydrogenase activity
MT476_21820	COG4175	Glycine betaine
MT476_21825	COG4176	ABC-type proline glycine betaine transport system permease component
MT476_21830	COG2226	methyltransferase
MT476_21835	COG3180	Ammonia monooxygenase
MT476_21840	COG0583	DNA-binding transcription factor activity
MT476_21850	COG3181	Tripartite tricarboxylate transporter family receptor
MT476_21855	COG4565	transcriptional regulatory protein
MT476_21860	COG3290	protein histidine kinase activity
MT476_21865	COG2851	Citrate transporter
MT476_21880	COG0179	Fumarylacetoacetate (FAA) hydrolase
MT476_21885	COG2040	homocysteine
MT476_21890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MT476_21905	COG1368	sulfuric ester hydrolase activity
MT476_21915	COG1476	TRANSCRIPTIONal
MT476_21955	COG3290	protein histidine kinase activity
MT476_21960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MT476_21965	COG1301	dicarboxylic acid transport
MT476_21975	COG0861	Integral membrane protein TerC family
MT476_21985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MT476_21990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MT476_22000	COG0833	amino acid
MT476_22005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MT476_22020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MT476_22030	COG0577	efflux transmembrane transporter activity
MT476_22035	COG1136	(ABC) transporter
MT476_22040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MT476_22055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MT476_22060	COG0390	transport system, permease component
MT476_22075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MT476_22080	COG1607	acyl-coa hydrolase
MT476_22095	COG0531	amino acid
MT476_22100	COG4297	protein containing double-stranded beta helix domain
MT476_22110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MT476_22115	COG1115	amino acid carrier protein
MT476_22120	COG2066	Belongs to the glutaminase family
MT476_22125	COG4191	Histidine kinase
MT476_22130	COG0784	Response regulator, receiver
MT476_22145	COG3052	prosthetic group binding
MT476_22165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MT476_22170	COG2814	Major facilitator Superfamily
MT476_22175	COG1733	regulation of RNA biosynthetic process
MT476_22185	COG4895	conserved protein (DUF2196)
MT476_22195	COG0028	Belongs to the TPP enzyme family
MT476_22200	COG3527	Alpha-acetolactate decarboxylase
MT476_22205	COG2223	nitrite transmembrane transporter activity
MT476_22210	COG0243	molybdopterin cofactor binding
MT476_22215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MT476_22225	COG1346	cytolysis
MT476_22235	COG3279	Response regulator of the LytR AlgR family
MT476_22240	COG3275	phosphorelay sensor kinase activity
MT476_22255	COG2204	response regulator
MT476_22260	COG1486	melibiose metabolic process
MT476_22265	COG1447	Phosphotransferase system cellobiose-specific component IIA
MT476_22270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MT476_22275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MT476_22280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MT476_22280	COG3711	transcriptional antiterminator
MT476_22285	COG1309	transcriptional regulator
MT476_22290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MT476_22300	COG1113	amino acid transport
MT476_22305	COG3142	Participates in the control of copper homeostasis
MT476_22330	COG1522	sequence-specific DNA binding
MT476_22350	COG1953	Uracil, thiamine, allantoin
MT476_22355	COG1070	Carbohydrate kinase
MT476_22360	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MT476_22365	COG1737	Transcriptional regulator
MT476_22375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MT476_22390	COG2382	esterase
MT476_22400	COG2153	protein acetylation
MT476_22405	COG2323	membrane
MT476_22415	COG0210	DNA helicase
MT476_22470	COG0475	glutathione-regulated potassium exporter activity
MT476_22470	COG0569	domain protein
MT476_22475	COG2239	Acts as a magnesium transporter
MT476_22485	COG0564	pseudouridine synthase activity
MT476_22495	COG2357	RelA SpoT domain protein
MT476_22505	COG4116	CYTH
MT476_22510	COG0741	lytic transglycosylase activity
MT476_22515	COG2346	COG2346, Truncated hemoglobins
MT476_22520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MT476_22530	COG1164	Oligoendopeptidase f
MT476_22540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MT476_22550	COG0861	Integral membrane protein TerC family
MT476_22565	COG0583	DNA-binding transcription factor activity
MT476_22570	COG1393	Belongs to the ArsC family
MT476_22575	COG0531	amino acid
MT476_22580	COG1113	amino acid transport
MT476_22585	COG0456	acetyltransferase
MT476_22590	COG4608	Belongs to the ABC transporter superfamily
MT476_22595	COG0444	Belongs to the ABC transporter superfamily
MT476_22600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MT476_22605	COG0601	transmembrane transport
MT476_22610	COG4166	transmembrane transport
MT476_22615	COG0180	Tryptophanyl-tRNA synthetase
MT476_22635	COG0601	transmembrane transport
MT476_22645	COG4608	Belongs to the ABC transporter superfamily
MT476_22650	COG0444	Belongs to the ABC transporter superfamily
MT476_22655	COG5504	Zn-dependent protease
MT476_22660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MT476_22665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MT476_22685	COG2267	carboxylic ester hydrolase activity
MT476_22695	COG2084	Dehydrogenase
MT476_22700	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MT476_22705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MT476_22720	COG0542	response to heat
MT476_22735	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MT476_22755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MT476_22760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MT476_22765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MT476_22770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MT476_22775	COG2151	metal-sulfur cluster biosynthetic enzyme
MT476_22780	COG0561	phosphatase activity
MT476_22795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_22800	COG1307	EDD domain protein, DegV family
MT476_22810	COG2996	Protein conserved in bacteria
MT476_22815	COG1666	GTP binding
MT476_22820	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_22825	COG3829	transcription factor binding
MT476_22830	COG0833	amino acid
MT476_22835	COG4187	Peptidase family M20/M25/M40
MT476_22840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MT476_22845	COG1012	belongs to the aldehyde dehydrogenase family
MT476_22850	COG1609	Transcriptional regulator
MT476_22855	COG1874	Beta-galactosidase
MT476_22855	COG0366	Alpha amylase catalytic
MT476_22860	COG0004	ammonium transporteR
MT476_22865	COG0347	Belongs to the P(II) protein family
MT476_22870	COG1562	ergosterol biosynthetic process
MT476_22885	COG0367	asparagine synthase
MT476_22900	COG2311	Membrane
MT476_22935	COG1403	HNH endonuclease
MT476_22940	COG0419	ATPase involved in DNA repair
MT476_22945	COG0420	3'-5' exonuclease activity
MT476_22950	COG1074	ATP-dependent DNA helicase activity
MT476_22955	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MT476_22960	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_22965	COG0398	Pfam SNARE associated Golgi protein
MT476_22970	COG4946	Tricorn protease homolog
MT476_22970	COG1506	peptidase
MT476_22970	COG0823	Involved in the tonB-independent uptake of proteins
MT476_22980	COG2224	Isocitrate lyase
MT476_22985	COG0501	Belongs to the peptidase M48B family
MT476_23100	COG1024	Enoyl-CoA hydratase
MT476_23105	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_23110	COG0095	Lipoate-protein ligase
MT476_23115	COG1234	tRNA 3'-trailer cleavage
MT476_23130	COG2972	Histidine kinase
MT476_23140	COG0768	penicillin binding
MT476_23145	COG1309	transcriptional regulator
MT476_23150	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MT476_23155	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MT476_23160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MT476_23165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MT476_23170	COG2329	Antibiotic biosynthesis monooxygenase
MT476_23175	COG3069	C4-dicarboxylate transmembrane transporter activity
MT476_23180	COG0671	phosphoesterase, PA-phosphatase related
MT476_23185	COG1473	amidohydrolase
MT476_23195	COG4473	ABC transporter
MT476_23200	COG1131	(ABC) transporter
MT476_23205	COG0537	adenosine 5'-monophosphoramidase activity
MT476_23210	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MT476_23210	COG2755	lipolytic protein G-D-S-L family
MT476_23215	COG2153	protein acetylation
MT476_23220	COG1695	Transcriptional regulator
MT476_23225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MT476_23240	COG1846	Transcriptional regulator
MT476_23265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MT476_23275	COG3481	metal-dependent phosphohydrolase, HD sub domain
MT476_23280	COG1668	transmembrane transport
MT476_23285	COG4152	abc transporter atp-binding protein
MT476_23300	COG1024	Enoyl-CoA hydratase
MT476_23305	COG0318	PFAM AMP-dependent synthetase and ligase
MT476_23310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MT476_23315	COG0561	phosphatase activity
MT476_23320	COG3679	Belongs to the UPF0342 family
MT476_23330	COG0189	ligase activity
MT476_23335	COG0189	ligase activity
MT476_23350	COG2508	Transcriptional regulator
MT476_23355	COG3842	ATPase activity
MT476_23375	COG1253	flavin adenine dinucleotide binding
MT476_23380	COG0702	epimerase
MT476_23395	COG0351	phosphomethylpyrimidine kinase
MT476_23400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MT476_23415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MT476_23420	COG0352	thiamine-phosphate diphosphorylase activity
MT476_23430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MT476_23435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MT476_23440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MT476_23445	COG0765	amino acid transport
MT476_23450	COG1126	abc transporter atp-binding protein
MT476_23460	COG0604	alcohol dehydrogenase
MT476_23465	COG1959	2 iron, 2 sulfur cluster binding
MT476_23475	COG2719	SpoVR family
MT476_23485	COG1268	BioY protein
MT476_23490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MT476_23495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MT476_23500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MT476_23505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MT476_23510	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MT476_23515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MT476_23515	COG3153	acetyltransferase
MT476_23525	COG1376	ErfK ybiS ycfS ynhG family protein
MT476_23530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MT476_23535	COG0673	inositol 2-dehydrogenase activity
MT476_23545	COG0564	pseudouridine synthase activity
MT476_23550	COG0840	transmembrane signaling receptor activity
MT476_23555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MT476_23565	COG1620	l-lactate permease
MT476_23570	COG0604	alcohol dehydrogenase
MT476_23585	COG0628	permease
MT476_23595	COG2962	Rard protein
MT476_23600	COG0084	hydrolase, TatD family'
MT476_23620	COG0747	negative chemotaxis
MT476_23625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MT476_23630	COG1942	4-Oxalocrotonate Tautomerase
MT476_23645	COG1187	pseudouridine synthase activity
MT476_23650	COG0477	Major facilitator Superfamily
MT476_23675	COG1522	sequence-specific DNA binding
MT476_23680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_23690	COG3718	enzyme involved in inositol metabolism
MT476_23695	COG1609	Transcriptional regulator
MT476_23720	COG0673	inositol 2-dehydrogenase activity
MT476_23725	COG2814	Major facilitator Superfamily
MT476_23730	COG1609	Transcriptional regulator
MT476_23755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MT476_23760	COG0456	acetyltransferase
MT476_23760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MT476_23770	COG3103	Sh3 type 3 domain protein
MT476_23780	COG1876	peptidase activity
MT476_23835	COG4948	Mandelate Racemase Muconate Lactonizing
MT476_23850	COG0584	glycerophosphoryl diester phosphodiesterase
MT476_23855	COG1653	transport
MT476_23860	COG0395	ABC-type sugar transport system, permease component
MT476_23865	COG1175	transmembrane transport
MT476_23870	COG3842	ATPase activity
MT476_23875	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MT476_23880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MT476_23895	COG0531	amino acid
MT476_23900	COG2217	Heavy metal translocating P-type atpase
MT476_23905	COG0586	Pfam SNARE associated Golgi protein
MT476_23910	COG0628	permease
MT476_23915	COG1301	dicarboxylic acid transport
MT476_23920	COG1968	undecaprenyl-diphosphatase activity
MT476_23930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MT476_23950	COG0697	spore germination
MT476_23955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MT476_23970	COG2766	serine protein kinase
MT476_23975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MT476_23990	COG3382	B3 4 domain protein
MT476_24105	COG0735	belongs to the Fur family
MT476_24110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MT476_24130	COG4555	ABC transporter
MT476_24135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MT476_24140	COG4129	membrane
MT476_24145	COG1132	(ABC) transporter
MT476_24150	COG3557	Belongs to the UPF0374 family
MT476_24165	COG1028	Short-chain dehydrogenase reductase Sdr
MT476_24175	COG1194	a g-specific adenine glycosylase
MT476_24180	COG1988	membrane-bound metal-dependent
MT476_24200	COG4221	oxidoreductase activity
MT476_24210	COG1090	epimerase
MT476_24230	COG5002	protein histidine kinase activity
MT476_24235	COG1113	amino acid transport
MT476_24245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MT476_24265	COG0535	radical SAM domain protein
MT476_24275	COG0387	Pfam Sodium calcium exchanger
MT476_24280	COG3871	stress protein (general stress protein 26)
MT476_24290	COG3479	Phenolic acid decarboxylase
MT476_24300	COG0477	Major facilitator Superfamily
MT476_24310	COG0640	Transcriptional regulator
MT476_24320	COG2217	Heavy metal translocating P-type atpase
MT476_24325	COG1295	ribonuclease BN
MT476_24330	COG4980	gas vesicle protein
MT476_24335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MT476_24340	COG4840	Belongs to the UPF0435 family
MT476_24345	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MT476_24350	COG2340	Cysteine-rich secretory protein family
MT476_24355	COG0693	protein deglycase activity
MT476_24365	COG1017	nitric oxide dioxygenase activity
MT476_24365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MT476_24370	COG1959	2 iron, 2 sulfur cluster binding
MT476_24380	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MT476_24390	COG0488	(ABC) transporter
MT476_24405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MT476_24415	COG2356	endonuclease I
MT476_24430	COG1511	domain protein
MT476_24435	COG0433	COG0433 Predicted ATPase
MT476_24435	COG1674	ftsk spoiiie
MT476_24440	COG4499	WXG100 protein secretion system (Wss), protein YukC
MT476_24445	COG5417	Belongs to the EsaB family
MT476_24450	COG4842	Belongs to the WXG100 family
MT476_24470	COG0513	Belongs to the DEAD box helicase family
MT476_24475	COG4191	Histidine kinase
MT476_24490	COG4565	transcriptional regulatory protein
MT476_24495	COG3290	protein histidine kinase activity
MT476_24500	COG0598	Magnesium transport protein CorA
MT476_24505	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MT476_24520	COG1115	amino acid carrier protein
MT476_24530	COG2318	DinB family
MT476_24540	COG0693	protein deglycase activity
MT476_24545	COG2259	Doxx family
MT476_24555	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
MT476_24560	COG1764	response to oxidative stress
MT476_24565	COG0671	phosphoesterase, PA-phosphatase related
MT476_24580	COG2311	Membrane
MT476_24585	COG0745	RESPONSE REGULATOR receiver
MT476_24590	COG2205	protein histidine kinase activity
MT476_24595	COG0745	RESPONSE REGULATOR receiver
MT476_24600	COG5002	protein histidine kinase activity
MT476_24600	COG3850	Histidine kinase
MT476_24605	COG3212	peptidase
MT476_24610	COG3212	peptidase
MT476_24615	COG2733	membrane
MT476_24620	COG1113	amino acid transport
MT476_24625	COG0765	amino acid transport
MT476_24630	COG0765	amino acid transport
MT476_24635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MT476_24640	COG1126	abc transporter atp-binding protein
MT476_24645	COG1876	peptidase activity
MT476_24655	COG2814	Major facilitator Superfamily
MT476_24660	COG4978	Transcriptional regulator
MT476_24660	COG0789	Transcriptional regulator
MT476_24670	COG2706	6-phosphogluconolactonase activity
MT476_24675	COG0024	Methionine aminopeptidase
MT476_24680	COG3852	Histidine kinase
MT476_24685	COG1744	ABC transporter substrate-binding protein PnrA-like
MT476_24690	COG0166	Belongs to the GPI family
MT476_24700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MT476_24720	COG1597	lipid kinase activity
MT476_24730	COG0154	amidase activity
MT476_24735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MT476_24745	COG4851	CamS sex pheromone cAM373 precursor
MT476_24755	COG0210	DNA helicase
MT476_24765	COG0423	glycine-tRNA ligase activity
MT476_24770	COG4496	protein, YerC YecD
MT476_24775	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MT476_24785	COG0151	Belongs to the GarS family
MT476_24790	COG0138	bifunctional purine biosynthesis protein purh
MT476_24795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MT476_24800	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MT476_24805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MT476_24810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MT476_24815	COG0047	phosphoribosylformylglycinamidine synthase activity
MT476_24820	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MT476_24825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MT476_24830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MT476_24835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MT476_24840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MT476_24880	COG2252	PERMEase
MT476_24885	COG0519	Catalyzes the synthesis of GMP from XMP
MT476_24885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MT476_24890	COG1305	Transglutaminase-like
MT476_24895	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MT476_24900	COG0714	Associated with various cellular activities
MT476_24905	COG0459	protein refolding
MT476_24910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MT476_24915	COG1266	CAAX protease self-immunity
MT476_24925	COG0805	protein transport
MT476_24930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MT476_24935	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MT476_24940	COG0488	(ABC) transporter
MT476_24950	COG0456	acetyltransferase
MT476_24955	COG1214	PFAM Peptidase M22, glycoprotease
MT476_24960	COG0802	atpase or kinase
MT476_25055	COG2183	response to ionizing radiation
MT476_25060	COG2208	phosphoserine phosphatase activity
MT476_25065	COG1191	sigma factor activity
MT476_25075	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_25080	COG2208	phosphoserine phosphatase activity
MT476_25085	COG2172	sigma factor antagonist activity
MT476_25090	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_25095	COG1366	Belongs to the anti-sigma-factor antagonist family
MT476_25100	COG2337	Toxic component of a toxin-antitoxin (TA) module
MT476_25105	COG0864	Transcriptional regulator
MT476_25110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MT476_25115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MT476_25120	COG0736	holo-[acyl-carrier-protein] synthase activity
MT476_25125	COG0705	Rhomboid family
MT476_25130	COG4294	response to UV
MT476_25135	COG0513	Belongs to the DEAD box helicase family
MT476_25140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MT476_25145	COG1181	Belongs to the D-alanine--D-alanine ligase family
MT476_25165	COG5002	protein histidine kinase activity
MT476_25170	COG0745	RESPONSE REGULATOR receiver
MT476_25180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MT476_25185	COG1177	transmembrane transport
MT476_25205	COG1368	sulfuric ester hydrolase activity
MT476_25210	COG1970	mechanosensitive ion channel activity
MT476_25215	COG1376	ErfK ybiS ycfS ynhG family protein
MT476_25225	COG0246	Mannitol dehydrogenase
MT476_25230	COG3711	transcriptional antiterminator
MT476_25235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MT476_25235	COG2213	PTS system mannitol-specific
MT476_25240	COG4991	sh3 domain protein
MT476_25240	COG3103	Sh3 type 3 domain protein
MT476_25240	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_25250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MT476_25255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MT476_25265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MT476_25270	COG5662	AntiSigma factor
MT476_25275	COG1595	DNA-templated transcription, initiation
MT476_25350	COG0726	polysaccharide deacetylase
MT476_25355	COG2194	sulfuric ester hydrolase activity
MT476_25365	COG0583	DNA-binding transcription factor activity
MT476_25370	COG0489	protein tyrosine kinase activity
MT476_25375	COG0860	N-Acetylmuramoyl-L-alanine amidase
MT476_25390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MT476_25395	COG0101	tRNA pseudouridine synthase activity
MT476_25400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MT476_25405	COG1122	ATPase activity
MT476_25410	COG1122	ATPase activity
MT476_25415	COG0203	ribosomal protein L17
MT476_25420	COG0202	RNA polymerase activity
MT476_25430	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MT476_25435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MT476_25440	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MT476_25445	COG0024	Methionine aminopeptidase
MT476_25450	COG0563	adenylate kinase activity
MT476_25455	COG0201	protein transport
MT476_25465	COG1841	ribosomal large subunit assembly
MT476_25470	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MT476_25475	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MT476_25490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MT476_25505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MT476_25510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MT476_25515	COG0255	Belongs to the universal ribosomal protein uL29 family
MT476_25520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MT476_25530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MT476_25535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MT476_25540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MT476_25545	COG0089	rRNA binding
MT476_25550	COG0088	Forms part of the polypeptide exit tunnel
MT476_25555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MT476_25560	COG0051	transcription antitermination factor activity, RNA binding
MT476_25565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MT476_25575	COG0049	tRNA binding
MT476_25580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MT476_25585	COG1358	cellular component organization or biogenesis
MT476_25590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MT476_25595	COG0085	RNA polymerase activity
MT476_25600	COG2813	Specifically methylates the guanine in position
MT476_25605	COG0222	ribosome binding
MT476_25610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MT476_25615	COG0081	regulation of translation
MT476_25620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MT476_25625	COG0250	Participates in transcription elongation, termination and antitermination
MT476_25630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MT476_25635	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MT476_25645	COG3688	RNA-binding protein containing a PIN domain
MT476_25650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MT476_25660	COG0215	cysteine-tRNA ligase activity
MT476_25665	COG1045	serine acetyltransferase
MT476_25670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MT476_25680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MT476_25685	COG4956	integral membrane protein (PIN domain superfamily)
MT476_25690	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MT476_25695	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MT476_25700	COG0542	response to heat
MT476_25705	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MT476_25710	COG3880	PFAM UvrB UvrC protein
MT476_25735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MT476_25740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MT476_25745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MT476_25750	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MT476_25755	COG0512	Glutamine amidotransferase of anthranilate synthase
MT476_25760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MT476_25765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MT476_25770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MT476_25775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MT476_25780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MT476_25785	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MT476_25790	COG0037	tRNA processing
MT476_25795	COG0515	serine threonine protein kinase
MT476_25800	COG2304	oxidoreductase activity
MT476_25820	COG1098	S1 RNA binding domain
MT476_25825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MT476_25840	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MT476_25845	COG3956	TIGRFAM MazG family protein
MT476_25850	COG2244	polysaccharide biosynthetic process
MT476_25855	COG2002	toxin-antitoxin pair type II binding
MT476_25860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MT476_25870	COG0193	aminoacyl-tRNA hydrolase activity
MT476_25875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MT476_25885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MT476_25890	COG2088	sporulation resulting in formation of a cellular spore
MT476_25895	COG0251	oxidation-reduction process
MT476_25900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MT476_25915	COG4466	Protein conserved in bacteria
MT476_25925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MT476_25935	COG0084	hydrolase, TatD family'
MT476_25945	COG2002	toxin-antitoxin pair type II binding
MT476_25950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MT476_25955	COG2827	Endonuclease containing a URI domain
MT476_25960	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MT476_25965	COG4467	Involved in initiation control of chromosome replication
MT476_25970	COG1774	PSP1 C-terminal conserved region
MT476_25975	COG0470	DNA polymerase III
MT476_25980	COG3870	Protein conserved in bacteria
MT476_25985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MT476_25990	COG1982	Orn Lys Arg decarboxylase major
MT476_26095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MT476_26100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MT476_26105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MT476_26115	COG0590	tRNA wobble adenosine to inosine editing
MT476_26120	COG1335	isochorismatase
MT476_26125	COG1388	LysM domain
MT476_26125	COG3858	chitin binding
MT476_26130	COG1428	Deoxynucleoside kinase
MT476_26135	COG1428	Deoxynucleoside kinase
MT476_26150	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MT476_26165	COG0516	GMP reductase activity
MT476_26165	COG0517	IMP dehydrogenase activity
MT476_26200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MT476_26205	COG0187	DNA topoisomerase II activity
MT476_26210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MT476_26215	COG2501	S4 domain
MT476_26220	COG0592	DNA-directed DNA polymerase activity
MT476_26255	COG3279	Response regulator of the LytR AlgR family
MT476_26260	COG1695	Transcriptional regulator
MT476_26285	COG0515	serine threonine protein kinase
MT476_26300	COG1132	(ABC) transporter
MT476_26315	COG4191	Histidine kinase
MT476_26410	COG1063	alcohol dehydrogenase
MT476_26420	COG4977	sequence-specific DNA binding
MT476_26420	COG1917	Cupin 2, conserved barrel domain protein
MT476_26425	COG1070	Carbohydrate kinase
MT476_26445	COG0728	peptidoglycan biosynthetic process
MT476_26505	COG0825	malonyl-CoA metabolic process
MT476_26520	COG2318	DinB family
MT476_26535	COG0658	competence protein
MT476_26535	COG2333	competence protein COMEC
MT476_26560	COG1714	RDD family
MT476_26600	COG1073	alpha beta
MT476_26605	COG3852	Histidine kinase
MT476_26610	COG2197	response regulator
MT476_26715	COG0791	NLP P60 protein
MT476_26715	COG0741	lytic transglycosylase activity
MT476_26775	COG1376	ErfK ybiS ycfS ynhG family protein
MT476_26780	COG2002	toxin-antitoxin pair type II binding
MT476_26785	COG0776	regulation of translation
MT476_26800	COG0596	Alpha beta hydrolase
MT476_26850	COG0772	Belongs to the SEDS family
MT476_26865	COG0772	Belongs to the SEDS family
MT476_26905	COG1388	LysM domain
MT476_26940	COG1595	DNA-templated transcription, initiation
MT476_26950	COG0640	Transcriptional regulator
MT476_26965	COG1253	flavin adenine dinucleotide binding
MT476_26985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MT476_26990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MT476_27015	COG2002	toxin-antitoxin pair type II binding
MT476_27050	COG0277	FAD linked oxidase domain protein
MT476_27095	COG1086	Polysaccharide biosynthesis protein
MT476_27130	COG1216	Glycosyl transferase, family 2
MT476_27145	COG1216	Glycosyl transferase, family 2
MT476_27160	COG1216	Glycosyl transferase, family 2
MT476_27205	COG0438	transferase activity, transferring glycosyl groups
MT476_27280	COG4974	Belongs to the 'phage' integrase family
MT476_27320	COG0328	RNA-DNA hybrid ribonuclease activity