locus-tag class description CU648_00005 ENOG4105FDR Membrane CU648_00065 ENOG4105MSI germination protein ypeb CU648_00090 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) CU648_00100 ENOG4107Z3H Transcriptional regulator, TetR family CU648_00135 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CU648_00150 ENOG4108MK9 spermidine N(1)-acetyltransferase CU648_00155 ENOG4105E98 transcriptional regulator DeoR family CU648_00190 ENOG4107QKR Dehydrogenase CU648_00200 ENOG4107RUY (E1 component), alpha subunit CU648_00210 ENOG4105E1F short-chain dehydrogenase reductase CU648_00215 ENOG4105RHY Pfam:UPF0157 CU648_00255 ENOG4107SQ8 Glycine betaine CU648_00260 ENOG4108IJ7 Glycine betaine CU648_00285 ENOG4105E66 phosphoriboisomerase A CU648_00290 ENOG41082BV acetyltransferase CU648_00295 ENOG4108M1A Chitin-binding protein CU648_00320 ENOG4105MSB protein, conserved in bacteria CU648_00330 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CU648_00360 ENOG4108Z7F N-acetyltransferase CU648_00380 ENOG4105EEM helicase CU648_00400 ENOG4105C9U ATP-dependent DNA helicase RecQ CU648_00455 ENOG4108M1A Chitin-binding protein CU648_00475 ENOG4105BZG amino acid carrier protein CU648_00480 ENOG4105C26 Dehydrogenase CU648_00485 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CU648_00490 ENOG4105CTU Proline racemase CU648_00495 ENOG4105CTU Proline racemase CU648_00500 ENOG41080HI glycine oxidase CU648_00510 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CU648_00540 ENOG4107T5V SNARE associated Golgi CU648_00555 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CU648_00560 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CU648_00575 ENOG4105DTQ mandelate racemase muconate lactonizing CU648_00620 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CU648_00625 ENOG4105BZU Histidine kinase CU648_00630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_00660 ENOG4105DPN Oligoendopeptidase f CU648_00665 ENOG4105DVH amino acid CU648_00675 ENOG4105EPR degv family CU648_00735 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CU648_00740 ENOG4106K7D Major facilitator family transporter CU648_00760 ENOG4107BMA Transglycosylase associated protein CU648_00775 ENOG41089UC methyltransferase, type 11 CU648_00815 ENOG4105CHM Aminotransferase CU648_00830 ENOG4108ZMI UPF0477 protein CU648_00850 ENOG4105DVE abc transporter atp-binding protein CU648_00910 ENOG4105C02 permease CU648_00925 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CU648_00930 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CU648_00935 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CU648_00960 ENOG4105E09 nadh pyrophosphatase CU648_00980 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CU648_01035 ENOG4107VC0 DNA alkylation repair enzyme CU648_01050 ENOG4107VMI polysaccharide deacetylase CU648_01060 ENOG4108ZCF integral membrane protein CU648_01065 ENOG4105E0M Sulfatase CU648_01075 ENOG4105C5H ABC transporter CU648_01085 ENOG4105EYF MMPL domain protein CU648_01090 ENOG41082JN Transcriptional regulator CU648_01110 ENOG4105CIH Imidazole acetol-phosphate transaminase CU648_01125 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CU648_01165 ENOG41069ER domain protein CU648_01180 ENOG4105EMN RNA polymerase sigma factor CU648_01205 ENOG4105D4B ABC, transporter CU648_01215 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CU648_01225 ENOG4105DKT Transcriptional regulator CU648_01230 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CU648_01240 ENOG41061GT Aldolase CU648_01265 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CU648_01295 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CU648_01305 ENOG4105II7 pyrroline-5-carboxylate reductase CU648_01315 ENOG4107258 Transcriptional regulator CU648_01345 ENOG4105E0Y RtcB Protein CU648_01350 ENOG4105ECK Fatty Acid Desaturase CU648_01355 ENOG4105G6Z alkaline phosphatase CU648_01365 ENOG4105VMP Transcriptional regulator CU648_01380 ENOG41090T1 Membrane CU648_01390 ENOG4108WCX response regulator CU648_01410 ENOG41068WN CU648_01440 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CU648_01465 ENOG4105CKK Glycosyl transferase, family 2 CU648_01485 ENOG4105CKK Glycosyl transferase, family 2 CU648_01495 ENOG4105C8Y Acetylornithine aminotransferase CU648_01500 ENOG4105CH6 catalase CU648_01535 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CU648_01545 ENOG4108TVJ Nitroreductase CU648_01550 ENOG4105FS7 Transcriptional regulator CU648_01570 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CU648_01590 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CU648_01605 ENOG4105CMR udp-glucose 4-epimerase CU648_01610 ENOG4105C19 ABC transporter CU648_01640 ENOG4108XET gCN5-related N-acetyltransferase CU648_01710 ENOG410635A Membrane CU648_01715 ENOG4105KNA -acetyltransferase CU648_01720 ENOG4108IQI permease CU648_01730 ENOG4105F1N DNA alkylation repair CU648_01760 ENOG4107RF6 penicillin-binding protein CU648_01770 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CU648_01800 ENOG4105P4J Allophanate hydrolase, subunit 1 CU648_01805 ENOG4107258 Transcriptional regulator CU648_01820 ENOG4106N3A copper homeostasis protein cutc CU648_01830 ENOG4108ZRV stage ii sporulation protein p CU648_01840 ENOG4108ZHR arsR family transcriptional regulator CU648_01850 ENOG4105FDT acyl-CoA dehydrogenase CU648_01865 ENOG4105DWD nucleoside recognition domain protein CU648_01895 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CU648_01975 ENOG4105E2A Dehydrogenase CU648_02000 ENOG4105ZX1 Transposase C CU648_02005 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CU648_02010 ENOG4108FPN Integrase CU648_02020 ENOG4105CHJ isochorismatase hydrolase CU648_02025 ENOG4107V0Z fmn reductase CU648_02070 ENOG4105ENA helicase CU648_02075 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CU648_02085 ENOG4105CGH 5'-nucleotidase CU648_02090 ENOG4105CH6 catalase CU648_02135 ENOG4108606 TspO/MBR family CU648_02140 ENOG4105CVP deoxyribo-dipyrimidine photolyase CU648_02155 ENOG4108TWJ NADH dehydrogenase subunit 5 CU648_02160 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CU648_02175 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CU648_02185 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CU648_02190 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CU648_02200 ENOG4105DSE periplasmic solute binding protein CU648_02205 ENOG4105CC5 ABC transporter CU648_02210 ENOG4105DIK (ABC) transporter CU648_02240 ENOG4105D6J arsenicaL-resistance protein CU648_02245 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CU648_02250 ENOG41085FC arsR family transcriptional regulator CU648_02265 ENOG4105F7F Chaperone CU648_02275 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CU648_02280 ENOG4108YXU transcriptional regulator AsnC family CU648_02330 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CU648_02340 ENOG4105C0R drug resistance transporter emrb qaca subfamily CU648_02355 ENOG4105IIP Membrane CU648_02370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_02375 ENOG41062D9 Histidine kinase CU648_02410 ENOG4105K6H D-cysteine desulfhydrase CU648_02435 ENOG4108NNI Beta-lactamase domain-containing protein CU648_02440 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CU648_02450 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CU648_02465 ENOG4105C88 aminopeptidase CU648_02480 ENOG4105W1Y Transcriptional regulator CU648_02485 ENOG4105JQZ Methyltransferase CU648_02505 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CU648_02520 ENOG4105BZU Histidine kinase CU648_02530 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CU648_02550 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CU648_02565 ENOG4108JQ1 Dehydrogenase CU648_02585 ENOG4108AEY RNA polymerase sigma factor CU648_02600 ENOG41082W1 Cupin 2, conserved barrel domain protein CU648_02610 ENOG410874W AraC family transcriptional regulator CU648_02625 ENOG4108IBT Inherit from COG: transposase CU648_02640 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CU648_02650 ENOG4108IG5 Transcriptional regulator CU648_02695 ENOG4108ISG Major Facilitator CU648_02705 ENOG4107MII Sugar-specific transcriptional regulator TrmB CU648_02710 ENOG4105CZM Major Facilitator CU648_02730 ENOG4105DA5 (ABC) transporter CU648_02735 ENOG41069JR CU648_02745 ENOG4105RXJ CU648_02750 ENOG4105KPY Small multidrug resistance protein CU648_02755 ENOG4105KBX Transcriptional regulator, TetR family CU648_02765 ENOG4105CRW Short chain fatty acid transporter CU648_02805 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CU648_02840 ENOG4105EQ0 Major Facilitator superfamily CU648_02845 ENOG4108IND Tetr family transcriptional regulator CU648_02850 ENOG4107TXC Transcriptional regulator CU648_02875 ENOG4108Z66 YbaK ebsC protein CU648_02900 ENOG4105KVH Transcriptional regulator CU648_02905 ENOG4108RCM Nitroreductase CU648_02930 ENOG4108PSK reductase CU648_02940 ENOG4105CJ1 ABC, transporter CU648_02995 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CU648_03000 ENOG4105DKQ ROK family CU648_03005 ENOG4106UW1 Major Facilitator superfamily CU648_03010 ENOG4108UW5 maltose o-acetyltransferase CU648_03015 ENOG4105C31 Tryptophanyl-tRNA synthetase CU648_03045 ENOG4105DMQ Methyltransferase CU648_03055 ENOG4105EV4 Multidrug resistance protein mdtH CU648_03085 ENOG4105C37 (CBS) domain CU648_03100 ENOG4105DDN Pentapeptide repeat-containing protein CU648_03105 ENOG4105XDF Protein of unknown function (DUF1272) CU648_03115 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CU648_03120 ENOG4105CMG Carbohydrate kinase CU648_03125 ENOG4105C6Z Gluconate CU648_03130 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CU648_03145 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CU648_03155 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CU648_03175 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CU648_03180 ENOG4105D4Y metalloprotease CU648_03190 ENOG4108UX3 '-nucleotidase CU648_03195 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CU648_03200 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CU648_03205 ENOG4105KVH Transcriptional regulator CU648_03240 ENOG4105C44 Serine transporter CU648_03280 ENOG4108TZY GntR Family Transcriptional Regulator CU648_03285 ENOG4105D9R oxidoreductase CU648_03290 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CU648_03295 ENOG4105KVH Transcriptional regulator CU648_03300 ENOG4105KVH Transcriptional regulator CU648_03340 ENOG4105JAB phenazine biosynthesis protein, phzf family CU648_03360 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CU648_03365 ENOG4105KVH Transcriptional regulator CU648_03375 ENOG4108ZJ4 polysaccharide deacetylase CU648_03435 ENOG4105KAF membrAne CU648_03465 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CU648_03485 ENOG4107YXZ hydrolase, family 25 CU648_03520 ENOG4105H3G oxidoreductase CU648_03610 ENOG4108TN2 lmbE family CU648_03620 ENOG4107R3E Citrate transporter CU648_03635 ENOG4108MES Periplasmic binding protein CU648_03640 ENOG4105EHG Permease protein CU648_03645 ENOG4105DQ5 transport system permease protein CU648_03650 ENOG4105NX3 Membrane CU648_03655 ENOG4107ZY0 Phenazine biosynthesis-like protein CU648_03675 ENOG4107V2S Transcriptional regulator CU648_03695 ENOG4105C98 muts2 protein CU648_03705 ENOG4105E5K Alpha-amylase CU648_03710 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CU648_03715 ENOG4105DPN Oligoendopeptidase f CU648_03720 ENOG4108A04 Beta-lactamase CU648_03750 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CU648_03775 ENOG41082BM Transcriptional regulator, arsr family CU648_03780 ENOG4105CIS alcohol dehydrogenase CU648_03810 ENOG4105C09 Bile acid CU648_03815 ENOG4105CQB FAD linked oxidase domain protein CU648_03845 ENOG4108UT6 Transferase hexapeptide repeat containing protein CU648_03855 ENOG4105K64 Glycosyl transferase, family 2 CU648_03860 ENOG4105E39 Enoyl-CoA hydratase CU648_03870 ENOG4105KT7 mgtC SapB transporter CU648_03885 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CU648_03890 ENOG41073R8 VanW family CU648_03900 ENOG4108R1P CU648_03920 ENOG4105VEQ Cold shock protein CU648_03940 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CU648_03960 ENOG410904N short-chain dehydrogenase reductase CU648_03970 ENOG4106IQC argininosuccinate lyase CU648_03985 ENOG4108IA2 Sodium pantothenate symporter CU648_03995 ENOG4105C26 Dehydrogenase CU648_04000 ENOG4105CHR reductase CU648_04015 ENOG4105EWU Squalene--hopene cyclase CU648_04025 ENOG4105FR1 rard protein CU648_04030 ENOG410696E Membrane CU648_04045 ENOG4105D1F ATP-binding protein CU648_04055 ENOG4108ZAF Molybdopterin CU648_04060 ENOG4105CVM Molybdenum cofactor synthesis domain protein CU648_04065 ENOG4105D06 uba thif-type nad fad binding protein CU648_04070 ENOG4105TMB Formate nitrite transporter CU648_04085 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CU648_04090 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CU648_04100 ENOG4108JB9 formate dehydrogenase CU648_04115 ENOG4105E1K spore germination protein CU648_04175 ENOG4107QJT sodium dicarboxylate symporter CU648_04180 ENOG4108KGH TRANSCRIPTIONal CU648_04190 ENOG4105EMN RNA polymerase sigma factor CU648_04215 ENOG4105CIG ABC transporter CU648_04225 ENOG4105ZX1 Transposase C CU648_04230 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CU648_04235 ENOG4108FPN Integrase CU648_04240 ENOG4105D9R oxidoreductase CU648_04250 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CU648_04260 ENOG4105K4P CoA-binding domain protein CU648_04265 ENOG4105C0H protease CU648_04270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_04280 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CU648_04285 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CU648_04290 ENOG4105W8X HesB YadR YfhF-family protein CU648_04320 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CU648_04330 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CU648_04345 ENOG4105BZ1 (ABC) transporter CU648_04350 ENOG4108I0Z Aconitate hydratase CU648_04390 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CU648_04410 ENOG4107F3J Amp-dependent synthetase and ligase CU648_04415 ENOG4107ZYJ bioY protein CU648_04420 ENOG4105CEY Amp-dependent synthetase and ligase CU648_04475 ENOG4107AYK membrAne CU648_04485 ENOG4105BZU Histidine kinase CU648_04490 ENOG4105FBA Phospholipase Carboxylesterase CU648_04495 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CU648_04500 ENOG4105CK7 Sodium proline symporter CU648_04505 ENOG4105CBC glutamate synthase CU648_04510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CU648_04515 ENOG4108VJ1 Transcriptional regulator (CarD family CU648_04520 ENOG4108903 Formimidoylglutamase CU648_04545 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CU648_04595 ENOG4107QIV Cytochrome c biogenesis protein CU648_04610 ENOG4105CH2 amidohydrolase CU648_04620 ENOG4105CJ1 ABC, transporter CU648_04630 ENOG4107RSM transcriptional regulator CU648_04640 ENOG41067MG lrgb family CU648_04670 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CU648_04685 ENOG4105BZ1 (ABC) transporter CU648_04690 ENOG4105BZ1 (ABC) transporter CU648_04730 ENOG4105CGH 5'-nucleotidase CU648_04740 ENOG4108SVB resolvase CU648_04760 ENOG4105K7K Transcriptional regulator CU648_04790 ENOG4105C5F glutamine synthetase CU648_04795 ENOG4105KV4 Transcriptional regulator CU648_04800 ENOG4105CXI aluminum resistance protein CU648_04805 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CU648_04810 ENOG4105EN6 Membrane CU648_04815 ENOG4106F1P AAA ATPase, central domain protein CU648_04845 ENOG41069ER domain protein CU648_04855 ENOG4105DM4 PTS System CU648_04860 ENOG4105DE4 1-phosphofructokinase CU648_04865 ENOG4105E98 transcriptional regulator DeoR family CU648_04870 ENOG4107QW4 alcohol dehydrogenase CU648_04875 ENOG4108SJC Membrane CU648_04890 ENOG4105C85 amino acid CU648_04915 ENOG4105TMB Formate nitrite transporter CU648_04920 ENOG4105K70 DNA-binding protein CU648_04930 ENOG4105C59 p-type ATPase CU648_04935 ENOG410681U heavy metal transport detoxification protein CU648_04940 ENOG4105VPX protein, conserved in bacteria CU648_04950 ENOG4105NIV Esterase CU648_04955 ENOG4105E0A ABC, transporter CU648_04975 ENOG4105CGK Exodeoxyribonuclease III CU648_04985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CU648_04990 ENOG4105D03 DNA-3-methyladenine glycosylase II CU648_05020 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CU648_05025 ENOG4105BZU Histidine kinase CU648_05045 ENOG41067MG lrgb family CU648_05060 ENOG4107TTQ Alpha beta hydrolase fold CU648_05065 ENOG4107YEI lmbE family CU648_05090 ENOG4105F0V Cell wall hydrolase CU648_05105 ENOG4105E0M Sulfatase CU648_05110 ENOG410890F Dynamin family CU648_05140 ENOG4105DA5 (ABC) transporter CU648_05170 ENOG4105DQU oxidoreductase, subunit beta CU648_05175 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CU648_05180 ENOG4108IGT Dipeptidase CU648_05185 ENOG4105MCT stage V sporulation protein S CU648_05190 ENOG4105D48 metallophosphoesterase CU648_05215 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CU648_05230 ENOG4105XZV Protein of unknown function (DUF3243) CU648_05235 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CU648_05255 ENOG4105UIB (ABC) transporter CU648_05260 ENOG4108JQ9 ABC transporter CU648_05265 ENOG4105DIH basic membrane CU648_05270 ENOG4105FDP GntR family transcriptional regulator CU648_05275 ENOG4107QZI cell division protein FtsK CU648_05285 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CU648_05300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CU648_05310 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CU648_05315 ENOG4108S0H Dipicolinic acid synthetase, b subunit CU648_05320 ENOG4105E35 Dipicolinate synthase subunit A CU648_05335 ENOG4105C1V Peptidase, M16 CU648_05355 ENOG4105DTN riboflavin biosynthesis protein ribF CU648_05360 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CU648_05370 ENOG4105W7A Protein of unknown function (DUF503) CU648_05380 ENOG4105VHM ribosomal protein CU648_05385 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CU648_05390 ENOG4105CHV Transcription elongation factor NusA CU648_05400 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CU648_05415 ENOG4105DZP Membrane-associated zinc metalloprotease CU648_05420 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CU648_05425 ENOG4105KNE Phosphatidate cytidylyltransferase CU648_05470 ENOG4108HE4 integrase family CU648_05480 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CU648_05485 ENOG4105C79 DNA protecting protein DprA CU648_05490 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CU648_05505 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CU648_05530 ENOG4105VB6 UPF0109 protein CU648_05550 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CU648_05555 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CU648_05570 ENOG4105CHR reductase CU648_05575 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CU648_05590 ENOG4105CB5 ATP-dependent DNA helicase recG CU648_05595 ENOG4105DP4 dak2 domain fusion protein ylov CU648_05600 ENOG4108ZAA Alkaline-shock protein CU648_05615 ENOG4105FJ0 thiamine CU648_05620 ENOG4105DJV ribulose-phosphate 3-epimerase CU648_05625 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CU648_05630 ENOG4105D9P serine threonine protein kinase CU648_05635 ENOG4108ZF3 Phosphatase CU648_05645 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CU648_05655 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CU648_05660 ENOG4105C25 Primosomal protein n' CU648_05665 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CU648_05685 ENOG4105DSJ YicC domain protein CU648_05695 ENOG4105F23 Fibronectin-binding protein CU648_05700 ENOG4105DC7 peptidase M24 CU648_05755 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CU648_05760 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CU648_05785 ENOG4105C34 Pseudouridine synthase CU648_05810 ENOG4105DBK s4 domain protein CU648_05815 ENOG41067XK integral membrane protein CU648_05825 ENOG4105DFA alanine racemase domain protein CU648_05830 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CU648_05835 ENOG4105WR5 sporulation protein, YlmC YmxH family CU648_05845 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CU648_05855 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CU648_05860 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CU648_05865 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CU648_05875 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CU648_05880 ENOG4105CNI cell division protein FtsW CU648_05895 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CU648_05900 ENOG4105CJN penicillin-binding protein CU648_05905 ENOG4105CJN penicillin-binding protein CU648_05910 ENOG41068DC Essential cell division protein (By similarity) CU648_05945 ENOG4105KNH Nucleic acid-binding protein CU648_05955 ENOG41063PX domain protein CU648_05960 ENOG4105D78 K07001 NTE family protein CU648_05965 ENOG4105H20 Sporulation integral membrane protein YlbJ CU648_05975 ENOG4106H78 methyltransferase CU648_05995 ENOG4107TB6 phosphoglycerate mutase CU648_06010 ENOG4106UY4 Inherit from COG: Scp-like extracellular CU648_06025 ENOG4105EKQ RNA-directed DNA polymerase CU648_06070 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CU648_06080 ENOG4105CNI cell division protein FtsW CU648_06095 ENOG4108IAB Phoh family CU648_06115 ENOG4105QA2 CU648_06120 ENOG4105CI3 gtp-binding protein typa CU648_06130 ENOG4105ECY inositol monophosphatase CU648_06150 ENOG4105CXN decarboxylase CU648_06200 ENOG4105CPP Dehydrogenase, E1 component CU648_06215 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CU648_06220 ENOG4108X4Q Hydrolase CU648_06235 ENOG4105CN5 Metallo-Beta-Lactamase CU648_06240 ENOG4107ZYR domain protein CU648_06275 ENOG4108XRC Protein of unknown function (DUF458) CU648_06290 ENOG4107IN1 Protein of unknown function (DUF1797) CU648_06305 ENOG4105EPM Diguanylate phosphodiesterase CU648_06310 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CU648_06330 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CU648_06340 ENOG4105UIN CU648_06410 ENOG4108HGU Histidine kinase CU648_06420 ENOG4105CHM Aminotransferase CU648_06425 ENOG4105FKQ transcriptional regulator CU648_06430 ENOG4105EG2 ABC transporter, permease CU648_06440 ENOG4107FKK extracellular solute-binding protein family 1 CU648_06450 ENOG4105CG3 alpha amylase, catalytic region CU648_06495 ENOG4105CHU acetyl-coa acetyltransferase CU648_06535 ENOG4105K7K Transcriptional regulator CU648_06540 ENOG4105DTD Dehydrogenase CU648_06560 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CU648_06600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CU648_06610 ENOG4106TD9 Diguanylate cyclase CU648_06630 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CU648_06645 ENOG4105CID antiterminator CU648_06655 ENOG4105FDP GntR family transcriptional regulator CU648_06665 ENOG4105CE4 GlcNAc 6-P deacetylase CU648_06710 ENOG4107ZE5 PPIases accelerate the folding of proteins CU648_06715 ENOG4105PTM secreted protein CU648_06720 ENOG4105J7I hydrolase CU648_06730 ENOG4105G6R Stage v sporulation protein ae CU648_06740 ENOG4105CZ3 stage V sporulation protein ad CU648_06745 ENOG41090VF Stage v sporulation protein ac CU648_06765 ENOG4105C8J )-transporter CU648_06770 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CU648_06780 ENOG41082AN stage II sporulation protein CU648_06785 ENOG4105DZ1 carboxypeptidase CU648_06795 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CU648_06800 ENOG4105DVE abc transporter atp-binding protein CU648_06835 ENOG4105D7N magnesium and cobalt transport protein CorA CU648_06860 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CU648_06870 ENOG4105I3K Ferric uptake regulator, Fur family CU648_06875 ENOG4105MZ9 stage II sporulation protein m CU648_06895 ENOG4105CPC Aldo Keto reductase CU648_06905 ENOG4105RHY Pfam:UPF0157 CU648_06925 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CU648_06935 ENOG4105ETE Transcriptional regulator (LacI family CU648_06940 ENOG4108YM7 Gcn5-related n-acetyltransferase CU648_06960 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CU648_06965 ENOG4108R6K riboflavin synthase, subunit alpha CU648_06985 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CU648_06990 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CU648_06995 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CU648_07010 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CU648_07025 ENOG4105DFD Na H antiporter CU648_07030 ENOG4105CGH 5'-nucleotidase CU648_07070 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CU648_07085 ENOG4108IXY short-chain dehydrogenase reductase CU648_07090 ENOG41069FQ Metallo-beta-lactamase superfamily CU648_07095 ENOG4105II7 pyrroline-5-carboxylate reductase CU648_07100 ENOG4105EJQ L-serine dehydratase CU648_07130 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CU648_07140 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CU648_07145 ENOG4105D9U N-acetyltransferase CU648_07160 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CU648_07165 ENOG4108QEG Membrane CU648_07170 ENOG4105CDA abc transporter atp-binding protein CU648_07175 ENOG4105E5Q amino acid AbC transporter CU648_07180 ENOG4108HW3 (ABC) transporter CU648_07195 ENOG4105G7B Protein of unknown function (DUF2992) CU648_07200 ENOG4105E09 nadh pyrophosphatase CU648_07215 ENOG4105C7S Dehydrogenase CU648_07220 ENOG4105CPP Dehydrogenase, E1 component CU648_07240 ENOG4107RDP Dehydrogenase CU648_07255 ENOG4108JUB Transcriptional regulator CU648_07265 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CU648_07280 ENOG4107QQR Sporulation CU648_07290 ENOG4105S1Z Stage IV sporulation protein B CU648_07295 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CU648_07305 ENOG4105DX0 Hemolysin A CU648_07315 ENOG4105CTB Polyprenyl synthetase CU648_07340 ENOG4108ZSR alkaline shock protein CU648_07345 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CU648_07370 ENOG410644B Stage III sporulation protein af CU648_07380 ENOG4105KQ4 Stage iii sporulation protein ad CU648_07385 ENOG4108CQH stage III sporulation protein AC CU648_07390 ENOG4105KR5 Stage iii sporulation protein CU648_07395 ENOG4105CD2 stage iii sporulation protein aa CU648_07420 ENOG4105DC7 peptidase M24 CU648_07435 ENOG4105CBJ Metal-dependent enzyme CU648_07445 ENOG4107YBY Hydrolase CU648_07465 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CU648_07470 ENOG4105WZW rhodanese family CU648_07490 ENOG41080TC multidrug resistance protein CU648_07530 ENOG4105CJ1 ABC, transporter CU648_07535 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CU648_07570 ENOG4105C0D helicase CU648_07620 ENOG4105D03 DNA-3-methyladenine glycosylase II CU648_07650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CU648_07680 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CU648_07785 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CU648_07790 ENOG4105C3R Methionine synthase CU648_07800 ENOG4105C28 cystathionine CU648_07805 ENOG4105C28 cystathionine CU648_07825 ENOG4105C5X domain protein CU648_07835 ENOG4105DKQ ROK family CU648_07845 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CU648_07860 ENOG4108UTW Plays a role in the regulation of phosphate uptake CU648_07865 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CU648_07870 ENOG4105E2Z phosphate ABC transporter (Permease CU648_07875 ENOG4105C8U phosphate abc transporter CU648_07880 ENOG4105PWN phosphate abc transporter CU648_07885 ENOG4107RF6 penicillin-binding protein CU648_07895 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CU648_07920 ENOG4105N80 Ferric uptake regulator, Fur family CU648_07930 ENOG4105FDK ABC transporter CU648_07935 ENOG4108JYZ YitT family CU648_07940 ENOG41069ZM Protein of unknown function (DUF2624) CU648_07965 ENOG4105EGD dinuclear metal center protein, YbgI family CU648_07980 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CU648_07985 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CU648_08020 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CU648_08025 ENOG4105KG3 cytidine deaminase CU648_08030 ENOG4107YR5 Diacylglycerol kinase CU648_08040 ENOG4105CTJ Metal Dependent Phosphohydrolase CU648_08045 ENOG4105C9A Phoh family CU648_08060 ENOG41068P3 sporulation protein YqfC CU648_08065 ENOG4105KTH gatB Yqey CU648_08075 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CU648_08080 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CU648_08100 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CU648_08110 ENOG4105CSA Coproporphyrinogen iii oxidase CU648_08115 ENOG4105KVH Transcriptional regulator CU648_08140 ENOG4105TQK DNA polymerase iii, delta' subunit CU648_08150 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CU648_08155 ENOG4108UK2 deaminase CU648_08160 ENOG4105KQC Competence protein CU648_08170 ENOG4105DXX methyltransferase CU648_08180 ENOG4108WF2 Metal Dependent Phosphohydrolase CU648_08190 ENOG410812S Rna-binding protein CU648_08200 ENOG4105CQW ribosome biogenesis GTPase YqeH CU648_08205 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CU648_08220 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CU648_08240 ENOG4108TVJ Nitroreductase CU648_08255 ENOG4105G6Z alkaline phosphatase CU648_08265 ENOG4108MUZ hydrolase CU648_08300 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CU648_08305 ENOG4105MIR Phenylalanine 4-monooxygenase CU648_08315 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CU648_08355 ENOG4105S6R Iron-hydroxamate transporter permease subunit CU648_08360 ENOG4108V5C ABC transporter CU648_08370 ENOG4108EKI Dehydrogenase CU648_08375 ENOG4105C28 cystathionine CU648_08405 ENOG4107XRG penicillin-binding protein CU648_08420 ENOG4105CFP Peptidase U32 CU648_08425 ENOG4105XYU peptidase (U32 family) CU648_08430 ENOG4108VQJ O-methyltransferase CU648_08435 ENOG4105HHA aminodeoxychorismate lyase CU648_08465 ENOG4105C02 permease CU648_08480 ENOG41060CR CU648_08485 ENOG4105C7H Helicase, RecD TraA family CU648_08500 ENOG4105C3J Cysteine desulfurase CU648_08510 ENOG4105D1H recombination factor protein RarA CU648_08515 ENOG4108VCI transcription factor, rsfa family CU648_08525 ENOG4105CUZ uba thif-type nad fad binding protein CU648_08535 ENOG4105CUT histidyl-tRNA synthetase CU648_08555 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CU648_08565 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CU648_08570 ENOG41076HS cation diffusion facilitator family transporter CU648_08575 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CU648_08585 ENOG4105CKP Polysaccharide Biosynthesis Protein CU648_08590 ENOG4108QG2 Membrane CU648_08600 ENOG4105VIE preprotein translocase, subunit YajC CU648_08615 ENOG41061AI Protein of unknown function (DUF2905) CU648_08630 ENOG4108HUF Transporter CU648_08665 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CU648_08670 ENOG4108IYU L-aspartate oxidase CU648_08685 ENOG4108RPX mosc domain containing protein CU648_08690 ENOG4105CQC Prephenate dehydratase CU648_08710 ENOG4105EWM Histidine kinase CU648_08735 ENOG4105X36 (ribosomal) protein CU648_08745 ENOG4105C03 ribonuclease CU648_08760 ENOG4107QMS site-determining protein CU648_08775 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CU648_08780 ENOG4105DFF Rod shape-determining protein mreb CU648_08790 ENOG4105C0R drug resistance transporter emrb qaca subfamily CU648_08795 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CU648_08800 ENOG4105ZX1 Transposase C CU648_08805 ENOG4108KU9 integrase family CU648_08810 ENOG4108FPN Integrase CU648_08835 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CU648_08840 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CU648_08850 ENOG41068KH stage VI sporulation protein D CU648_08860 ENOG4105D52 delta-aminolevulinic acid dehydratase CU648_08885 ENOG4105K56 Transcriptional regulator CU648_08905 ENOG4108IUQ atp-dependent protease CU648_08935 ENOG4108QCI YvbH-like oligomerisation region CU648_08960 ENOG4105M59 Phosphodiesterase, mj0936 family CU648_08975 ENOG4108XJQ germination protein CU648_08985 ENOG4108PCX Major Facilitator CU648_08995 ENOG4105KBX Transcriptional regulator, TetR family CU648_09010 ENOG4105PFC Transcriptional regulator CU648_09025 ENOG4105DZC cytosine deaminase CU648_09030 ENOG4105DZC cytosine deaminase CU648_09035 ENOG4105DEF Extracellular solute-binding protein, family 5 CU648_09040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CU648_09055 ENOG4108JQ7 (ABC) transporter CU648_09060 ENOG4108HRK Histidine kinase CU648_09065 ENOG4105DY9 regulatoR CU648_09075 ENOG41067S9 phage shock protein C, PspC CU648_09080 ENOG4108JCI Transcriptional regulator CU648_09090 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CU648_09095 ENOG4108Z40 Transcriptional regulator CU648_09100 ENOG4105RHA ABC transporter, permease CU648_09105 ENOG4108IUX (ABC) transporter CU648_09110 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CU648_09115 ENOG4105ER2 Ompa motb domain protein CU648_09120 ENOG4105E14 MotA TolQ exbB proton channel CU648_09125 ENOG4108VXD carboxy-peptidase CU648_09135 ENOG4105E33 succinate dehydrogenase CU648_09145 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CU648_09160 ENOG4105K63 Thioredoxin CU648_09165 ENOG4105C10 Electron transfer flavoprotein CU648_09170 ENOG4105BZJ Electron transfer flavoprotein CU648_09175 ENOG41060WC Enoyl-CoA hydratase CU648_09180 ENOG4107Z3H Transcriptional regulator, TetR family CU648_09185 ENOG4105CEY Amp-dependent synthetase and ligase CU648_09200 ENOG4105J76 Periplasmic binding protein CU648_09205 ENOG4105S6R Iron-hydroxamate transporter permease subunit CU648_09245 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CU648_09260 ENOG4105DR4 Methyltransferase CU648_09275 ENOG4105KFN sortase, SrtB family CU648_09280 ENOG4105E0A ABC, transporter CU648_09295 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CU648_09300 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) CU648_09310 ENOG4105FE9 pseudouridine synthase CU648_09325 ENOG4105DCG PHP domain protein CU648_09360 ENOG4105C5S asparaginyl-tRNA synthetase CU648_09375 ENOG4108RWN rrna methyltransferase CU648_09415 ENOG4105C0R drug resistance transporter emrb qaca subfamily CU648_09420 ENOG4105CW7 secretion protein, HlyD family CU648_09425 ENOG4108JGH Tetr family transcriptional regulator CU648_09430 ENOG4105CN9 Peptidase m42 family protein CU648_09450 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CU648_09455 ENOG4105C22 threonyL-tRNA synthetase CU648_09460 ENOG4108TDW sporulation protein YtxC CU648_09480 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CU648_09490 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CU648_09495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CU648_09505 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CU648_09510 ENOG4105C2M dna polymerase I CU648_09515 ENOG4105BZU Histidine kinase CU648_09520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CU648_09545 ENOG4108HMX isocitrate dehydrogenase (NADP) CU648_09550 ENOG4105BZN citrate synthase CU648_09565 ENOG4108REF Sporulation integral membrane protein ytvi CU648_09570 ENOG4105FS0 cytoplasmic membrane protein CU648_09595 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CU648_09600 ENOG4105C6K Malic enzyme CU648_09605 ENOG4105C0B DNA polymerase III (alpha subunit) CU648_09610 ENOG4105VV2 CU648_09620 ENOG4105SFS phosphoesterase RecJ domain protein CU648_09665 ENOG4105DC7 peptidase M24 CU648_09705 ENOG41082W1 Cupin 2, conserved barrel domain protein CU648_09715 ENOG4105VZ8 Transcriptional regulator CU648_09735 ENOG4107YZX Universal stress protein CU648_09785 ENOG4108JYZ YitT family CU648_09805 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CU648_09815 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CU648_09820 ENOG4105KBJ sporulation protein ytfj CU648_09835 ENOG4105EFZ amidohydrolase CU648_09845 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CU648_09870 ENOG4106KR7 LysR family Transcriptional regulator CU648_09880 ENOG4105U5Y Transcriptional regulator CU648_09890 ENOG4105C28 cystathionine CU648_09940 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CU648_09950 ENOG4105EMN RNA polymerase sigma factor CU648_09970 ENOG4105F1V Acetoin utilization protein CU648_09975 ENOG4105W87 Cbs domain CU648_09980 ENOG4105DGU Histone deacetylase CU648_09990 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CU648_09995 ENOG4105BZU Histidine kinase CU648_10005 ENOG4107SNB ankyrin repeat protein YahD CU648_10010 ENOG4105EP9 oxidoreductase CU648_10040 ENOG4105ETE Transcriptional regulator (LacI family CU648_10070 ENOG4105C88 aminopeptidase CU648_10095 ENOG4105K7K Transcriptional regulator CU648_10125 ENOG4108VDD TRNA binding domain protein CU648_10155 ENOG4105C8F Beta-lactamase domain protein CU648_10170 ENOG4108V15 phosphotransferase enzyme family CU648_10175 ENOG4108IUM Glycogen debranching enzyme CU648_10190 ENOG4107QSE Dipeptidase CU648_10195 ENOG4105YW5 deoR family transcriptional regulator CU648_10210 ENOG4105CBX hi0933 family CU648_10250 ENOG4108VJ1 Transcriptional regulator (CarD family CU648_10255 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CU648_10275 ENOG4108ZAF Molybdopterin CU648_10280 ENOG4105D7V transposase CU648_10290 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CU648_10295 ENOG4105CVM Molybdenum cofactor synthesis domain protein CU648_10305 ENOG4105D06 uba thif-type nad fad binding protein CU648_10310 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CU648_10330 ENOG41085GJ domain protein CU648_10340 ENOG4105DWV Homoserine O-trans-acetylase CU648_10350 ENOG4108B31 Spore germination protein CU648_10385 ENOG410605W Major Facilitator CU648_10390 ENOG4107S91 Sodium hydrogen exchanger CU648_10395 ENOG4105NCW Trka-c domain protein CU648_10410 ENOG4105C19 ABC transporter CU648_10435 ENOG4105N5T Radical SAM Protein CU648_10445 ENOG4105CIG ABC transporter CU648_10480 ENOG4105E8V Alpha Beta Hydrolase Fold protein CU648_10485 ENOG4108Z0R Transferase CU648_10490 ENOG4105YVM Phosphoesterase, PA-phosphatase related CU648_10495 ENOG4105BZF Glycosyl transferase (Group 1 CU648_10505 ENOG4108RIR Molybdenum cofactor biosynthesis protein CU648_10570 ENOG4105EGD dinuclear metal center protein, YbgI family CU648_10575 ENOG4105BZU Histidine kinase CU648_10580 ENOG4105BZU Histidine kinase CU648_10585 ENOG4107S9D Alpha beta hydrolase CU648_10590 ENOG4107T7U Sulfatase CU648_10610 ENOG4105D2X ABC transporter substrate-binding protein CU648_10620 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CU648_10635 ENOG4107XGZ Hydrolase CU648_10685 ENOG4108V2W Carbonate dehydratase CU648_10690 ENOG4105C4M (Ubiquinol oxidase) subunit I CU648_10695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CU648_10770 ENOG41087YS Phage shock protein A CU648_10825 ENOG4105BZU Histidine kinase CU648_10830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_10855 ENOG4108UGV hypoxanthine phosphoribosyltransferase CU648_10860 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CU648_10880 ENOG4105C19 ABC transporter CU648_10895 ENOG4107ZTW SNARE associated Golgi CU648_10920 ENOG4105C19 ABC transporter CU648_10925 ENOG41086D8 Transcriptional regulator CU648_10965 ENOG4105C6Z Gluconate CU648_10970 ENOG4105FDP GntR family transcriptional regulator CU648_10990 ENOG41069H0 dihydroorotase EC 3.5.2.3 CU648_11010 ENOG4105DTQ mandelate racemase muconate lactonizing CU648_11025 ENOG4108IPT Naphthoate synthase CU648_11030 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CU648_11040 ENOG4105E4F Isochorismate synthase CU648_11045 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CU648_11055 ENOG4105VEQ Cold shock protein CU648_11090 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CU648_11105 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CU648_11110 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CU648_11210 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CU648_11250 ENOG4105KT7 mgtC SapB transporter CU648_11255 ENOG4107PBV potassium channel CU648_11275 ENOG4105WG9 Conserved Protein CU648_11285 ENOG4105CHM Aminotransferase CU648_11290 ENOG4108ZB6 transcriptional regulator AsnC family CU648_11295 ENOG4105C5I Dehydrogenase CU648_11300 ENOG4108MUZ hydrolase CU648_11310 ENOG4105C87 Aminotransferase class I and II CU648_11320 ENOG4105Y38 Kinase-associated protein B CU648_11330 ENOG4107R3E Citrate transporter CU648_11350 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CU648_11355 ENOG4105KA0 thioesterase Superfamily protein CU648_11370 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CU648_11390 ENOG41069ER domain protein CU648_11405 ENOG4105CEP NADH dehydrogenase CU648_11435 ENOG4105EWC Purine nucleoside phosphorylase CU648_11455 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CU648_11480 ENOG4108JJA ABC, transporter CU648_11485 ENOG4105C4B ABC transporter, permease CU648_11490 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CU648_11535 ENOG41083MR nifu domain-containing protein CU648_11555 ENOG4108W5N phosphatidylglycerophosphatase a CU648_11565 ENOG4105DYS nad(p)h dehydrogenase (quinone) CU648_11575 ENOG4105D4U had-superfamily hydrolase, subfamily iia CU648_11590 ENOG4105CBT Fructose-1,6-bisphosphatase CU648_11610 ENOG4105MMD transcriptional regulator CU648_11615 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CU648_11620 ENOG4107TXC Transcriptional regulator CU648_11625 ENOG41090T1 Membrane CU648_11650 ENOG4105FAA peptidase M23 CU648_11660 ENOG4105KZD Domain of unknown function (DUF1805) CU648_11665 ENOG4107R8B 5'-nucleotidase CU648_11680 ENOG4105DIW FeS assembly protein SUFB CU648_11685 ENOG4108UNV SUF system FeS assembly protein, NifU family CU648_11690 ENOG4105C9B Cysteine desulfurase CU648_11695 ENOG4105JRK feS assembly protein SufD CU648_11700 ENOG4105C3K feS assembly ATPase SufC CU648_11705 ENOG4105D01 (LipO)protein CU648_11710 ENOG4105D01 (LipO)protein CU648_11715 ENOG4108UMI ABC transporter, permease CU648_11745 ENOG41080E8 Transcriptional regulator, Spx MgsR family CU648_11800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CU648_11835 ENOG4108W8B Beta-lactamase domain protein CU648_11840 ENOG4105C1G acyl-Coa dehydrogenase CU648_11850 ENOG4105CHU acetyl-coa acetyltransferase CU648_11870 ENOG4105DZ1 carboxypeptidase CU648_11890 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CU648_11905 ENOG4108SUT Major Facilitator Superfamily CU648_11910 ENOG4107R7I amino acid CU648_11925 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CU648_11935 ENOG4107AYK membrAne CU648_11980 ENOG4107ZTW SNARE associated Golgi CU648_11990 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CU648_11995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_12000 ENOG4105BZU Histidine kinase CU648_12025 ENOG4105C8Q Methyl-accepting chemotaxis CU648_12030 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CU648_12035 ENOG4105VG1 fes assembly suf system protein CU648_12040 ENOG4105D4Y metalloprotease CU648_12060 ENOG4107S91 Sodium hydrogen exchanger CU648_12065 ENOG4105NCW Trka-c domain protein CU648_12080 ENOG4108RMU ferritin dps family protein CU648_12100 ENOG4108URH decarboxylase CU648_12120 ENOG4105D9N nucleoside CU648_12125 ENOG4105D9N nucleoside CU648_12140 ENOG4108RYK Nad-dependent epimerase dehydratase CU648_12165 ENOG4105CV8 reductase CU648_12170 ENOG4105F27 Major Facilitator CU648_12175 ENOG4105KVH Transcriptional regulator CU648_12190 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CU648_12195 ENOG4105D4A Cell wall formation (By similarity) CU648_12205 ENOG4105C8Q Methyl-accepting chemotaxis CU648_12235 ENOG4108MK9 spermidine N(1)-acetyltransferase CU648_12255 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CU648_12285 ENOG4108IPW abc transporter atp-binding protein CU648_12290 ENOG4105CM4 permease protein CU648_12365 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CU648_12375 ENOG4105XZU Preprotein translocase, subunit SecG CU648_12380 ENOG41067MG lrgb family CU648_12400 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CU648_12430 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CU648_12450 ENOG41090VF Stage v sporulation protein ac CU648_12455 ENOG4105CZ3 stage V sporulation protein ad CU648_12470 ENOG4105H67 Protein of unknown function (DUF421) CU648_12475 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CU648_12485 ENOG4105KRI phosphocarrier protein (HPr CU648_12495 ENOG4105CHW UPF0052 protein CU648_12505 ENOG4108Z4K mutator MutT protein CU648_12515 ENOG4105C3M thioredoxin reductase CU648_12525 ENOG4108S4C acetyltransferase CU648_12545 ENOG41086DT Membrane protein of unknown function CU648_12555 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CU648_12575 ENOG4107TXC Transcriptional regulator CU648_12615 ENOG4105DUM transcriptional regulator, lysR family CU648_12625 ENOG4108WS4 fmn reductase CU648_12640 ENOG4105BZ1 (ABC) transporter CU648_12655 ENOG4105CN1 protease CU648_12660 ENOG4105CRP Part of the ABC transporter FtsEX involved in CU648_12665 ENOG4105CAK Cell division ATP-binding protein ftsE CU648_12690 ENOG4105MS2 ribosomal subunit Interface protein CU648_12695 ENOG4105VEQ Cold shock protein CU648_12700 ENOG41081UC Inherit from COG: Competence protein CU648_12710 ENOG4105K4H Nlp p60 protein CU648_12715 ENOG4105KVH Transcriptional regulator CU648_12730 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CU648_12735 ENOG4108KGH TRANSCRIPTIONal CU648_12740 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CU648_12745 ENOG4105C6Y Udp-glucose 6-dehydrogenase CU648_12750 ENOG4105ESV Glycosyl transferase, family 4 CU648_12760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CU648_12775 ENOG4105ZX1 Transposase C CU648_12780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CU648_12785 ENOG4108FPN Integrase CU648_12790 ENOG410901P UPF0249 protein CU648_12795 ENOG4105F8D glycoside hydrolase family 4 CU648_12800 ENOG4105VCP PTS System CU648_12805 ENOG4105CK1 PTS System CU648_12815 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CU648_12825 ENOG4105VCP PTS System CU648_12835 ENOG4105VZJ PTS System CU648_12875 ENOG4105ECB domain protein CU648_12880 ENOG4107RSM transcriptional regulator CU648_12945 ENOG4105DAA L-lactate CU648_12955 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CU648_12970 ENOG4105E0M Sulfatase CU648_13000 ENOG4107R8N Glycosyl transferase, family 2 CU648_13010 ENOG4105C94 Transporter CU648_13020 ENOG41069ER domain protein CU648_13045 ENOG4105KBK Zinc finger, swim domain protein CU648_13050 ENOG4105C0D helicase CU648_13080 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CU648_13095 ENOG4107RBB ABC transporter, permease CU648_13100 ENOG4105C19 ABC transporter CU648_13110 ENOG4105CXY transporter CU648_13125 ENOG4105BZU Histidine kinase CU648_13130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_13135 ENOG4105CMR udp-glucose 4-epimerase CU648_13145 ENOG4108KGH TRANSCRIPTIONal CU648_13155 ENOG4105C6Y Udp-glucose 6-dehydrogenase CU648_13170 ENOG4107T8Q Glycosyl transferase (Group 1 CU648_13185 ENOG4107SBE Glycosyl transferase (Group 1 CU648_13190 ENOG4105D7W serine acetyltransferase CU648_13195 ENOG4105D3Q Sugar transferase CU648_13200 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CU648_13210 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CU648_13215 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CU648_13220 ENOG4107YJ4 chain length determinant protein CU648_13225 ENOG4105HTX biosynthesis protein CU648_13230 ENOG4107YJ4 chain length determinant protein CU648_13245 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CU648_13255 ENOG4105FRN stage II sporulation protein CU648_13270 ENOG4105DY9 regulatoR CU648_13290 ENOG4106778 Protein of unknown function (DUF1146) CU648_13295 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CU648_13300 ENOG4105C8S subunit m CU648_13305 ENOG4105D65 subunit l CU648_13330 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CU648_13335 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CU648_13345 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CU648_13350 ENOG4105BZU Histidine kinase CU648_13405 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CU648_13410 ENOG41062M3 atp synthase CU648_13440 ENOG4108YZG isomerase CU648_13460 ENOG4108VGI doxx family CU648_13465 ENOG4107XC4 flavin reductase domain protein, FMN-binding CU648_13485 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CU648_13495 ENOG4108ZXQ stage ii sporulation protein r CU648_13500 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CU648_13505 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CU648_13520 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CU648_13525 ENOG4105CBT Fructose-1,6-bisphosphatase CU648_13535 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CU648_13570 ENOG4105C1G acyl-Coa dehydrogenase CU648_13575 ENOG4105C1G acyl-Coa dehydrogenase CU648_13580 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CU648_13590 ENOG4105DF6 Fe-S oxidoreductase CU648_13605 ENOG4105BZU Histidine kinase CU648_13630 ENOG4105BZU Histidine kinase CU648_13635 ENOG4105KCT ABC transporter CU648_13640 ENOG4108M15 ABC transporter CU648_13645 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CU648_13660 ENOG4105IIU Aminopeptidase CU648_13680 ENOG4105EMN RNA polymerase sigma factor CU648_13690 ENOG410684U Domain of unknown function (DUF1934) CU648_13710 ENOG4105CYW agmatinase CU648_13720 ENOG4105DXB Major Facilitator superfamily CU648_13725 ENOG4107SWG transcriptional regulator MERR family CU648_13730 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CU648_13735 ENOG4105BZ4 penicillin-binding protein CU648_13740 ENOG4108XFG YwhD family CU648_13745 ENOG4108Z4T Peptidase M50 CU648_13750 ENOG41069HH 4-oxalocrotonate tautomerase CU648_13755 ENOG4105DCI Phosphohydrolase CU648_13760 ENOG4108V5C ABC transporter CU648_13765 ENOG4105E0A ABC, transporter CU648_13770 ENOG4105EHG Permease protein CU648_13775 ENOG4105DQ5 transport system permease protein CU648_13785 ENOG4108VCI transcription factor, rsfa family CU648_13800 ENOG4108IJ2 phosphate acetyltransferase CU648_13815 ENOG4108VKI Cell wall hydrolase CU648_13835 ENOG4107SVH Potassium channel protein CU648_13845 ENOG410667J hydrolase CU648_13850 ENOG4105VCH membrane CU648_13875 ENOG4105VZ8 Transcriptional regulator CU648_13880 ENOG4105K63 Thioredoxin CU648_13890 ENOG4108TU7 Inherit from COG: (ABC) transporter CU648_13895 ENOG4105CJ1 ABC, transporter CU648_13900 ENOG41090WU lipolytic protein G-D-S-L family CU648_13915 ENOG4105D6E homoserine dehydrogenase CU648_13940 ENOG4108Y4K DNA-binding transcriptional activator CU648_13950 ENOG4105WH1 Two component transcriptional regulator luxr family CU648_13955 ENOG4105BZU Histidine kinase CU648_13960 ENOG4105DWF phosphomethylpyrimidine kinase CU648_13965 ENOG4105BZU Histidine kinase CU648_13970 ENOG4105VCD cytoplasmic protein CU648_13975 ENOG4105D22 carbon starvation protein CU648_13980 ENOG4105DY9 regulatoR CU648_13985 ENOG41079KZ Major Facilitator Superfamily CU648_14005 ENOG4105EN6 Membrane CU648_14010 ENOG4106YBV Methyl-accepting chemotaxis CU648_14020 ENOG4108S4H thioesterase Superfamily protein CU648_14030 ENOG4105JEU Glycosyl transferase, family 2 CU648_14035 ENOG4105C5H ABC transporter CU648_14055 ENOG4105CKK Glycosyl transferase, family 2 CU648_14060 ENOG41067SE Tetr family transcriptional regulator CU648_14070 ENOG4105E0X reductase CU648_14075 ENOG4106F5Q Membrane CU648_14090 ENOG4105DY9 regulatoR CU648_14095 ENOG4108HRK Histidine kinase CU648_14100 ENOG4107RGD Major Facilitator superfamily CU648_14120 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CU648_14130 ENOG4105IW1 AmiS UreI transporter CU648_14140 ENOG4105CMR udp-glucose 4-epimerase CU648_14145 ENOG4108UT2 hemolysin iii CU648_14155 ENOG4105C1J atp-dependent rna helicase CU648_14170 ENOG4105DPN Oligoendopeptidase f CU648_14190 ENOG4105C0H protease CU648_14195 ENOG4105Q2H domain protein CU648_14210 ENOG4105BZU Histidine kinase CU648_14215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_14245 ENOG4105CDU Replicative dna helicase CU648_14255 ENOG4105BZR domain protein CU648_14260 ENOG4108XMW Membrane CU648_14270 ENOG4108UUM single-stranded DNA-binding protein CU648_14280 ENOG4105C3G gtp-binding protein CU648_14285 ENOG4105VDK protein, conserved in bacteria CU648_14290 ENOG4105D8X mechanosensitive ion channel CU648_14295 ENOG4108ZDA Sporulation protein YyaC CU648_14300 ENOG4105FA0 parb-like partition protein CU648_14305 ENOG4107QJE Chromosome Partitioning Protein CU648_14335 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CU648_14355 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CU648_14360 ENOG410848D S4 domain protein YaaA CU648_14375 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CU648_14410 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CU648_14445 ENOG4105ZMH deoxynucleoside kinase CU648_14455 ENOG4105GTG Isochorismatase CU648_14465 ENOG4108Z6B deaminase CU648_14475 ENOG4105C6E dna polymerase iii CU648_14495 ENOG41067KS pro-sigma K processing CU648_14530 ENOG4105CXN decarboxylase CU648_14540 ENOG4105FA2 dna polymerase iii CU648_14545 ENOG4105MA4 psp1 domain protein CU648_14555 ENOG41060K3 Methyltransferase CU648_14565 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CU648_14570 ENOG4105KRN Transcriptional regulator, abrb family CU648_14580 ENOG4105F8V Hydrolase, tatD family CU648_14585 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CU648_14595 ENOG4105XFA sporulation peptidase YabG CU648_14600 ENOG4105W42 Veg protein CU648_14615 ENOG4105DFT pur operon repressor CU648_14625 ENOG4105KME endoribonuclease L-psp CU648_14640 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CU648_14645 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CU648_14655 ENOG4108JA2 transcriptioN-repair coupling factor CU648_14660 ENOG4108M14 stage v sporulation protein t CU648_14670 ENOG4108IY2 MazG family CU648_14675 ENOG41082I2 s4 domain protein CU648_14680 ENOG4105VYY sporulation protein yabp CU648_14695 ENOG41060GV RNA binding s1 domain protein CU648_14720 ENOG4108UGV hypoxanthine phosphoribosyltransferase CU648_14725 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CU648_14740 ENOG4105C6T cysteine synthase CU648_14745 ENOG4105CRQ synthase (Component I) CU648_14750 ENOG4105DDQ anthranilate synthase CU648_14755 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CU648_14760 ENOG4105EEI dihydropteroate synthase CU648_14765 ENOG4105KRF dihydroneopterin aldolase CU648_14770 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CU648_14780 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CU648_14870 ENOG4108Z0C Uvrb UvrC protein CU648_14885 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CU648_14895 ENOG4105CTP PilT protein domain protein CU648_14915 ENOG4105D7W serine acetyltransferase CU648_14930 ENOG4105C2N RNA methyltransferase TrmH family group 3 CU648_14935 ENOG4105M0M Tetracycline resistance protein CU648_14940 ENOG4105QIV RNA polymerase CU648_14955 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CU648_14980 ENOG4107Y49 methyltransferase CU648_14995 ENOG4105XPM ribosomal protein CU648_15100 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CU648_15125 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CU648_15135 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CU648_15145 ENOG41067V7 50S ribosomal protein L36 CU648_15175 ENOG4108JJB ABC transporter CU648_15180 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CU648_15185 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CU648_15210 ENOG4105D1F ATP-binding protein CU648_15225 ENOG4108NMV polysaccharide deacetylase CU648_15305 ENOG4105C8B TIGR00159 family CU648_15310 ENOG4107U5W ybbr family CU648_15350 ENOG4105CMG Carbohydrate kinase CU648_15360 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CU648_15385 ENOG4108PSK reductase CU648_15390 ENOG4108UMI ABC transporter, permease CU648_15400 ENOG4105D01 (LipO)protein CU648_15405 ENOG4105EE1 crotonyl-CoA reductase CU648_15415 ENOG4105IQ5 FAD linked oxidase domain protein CU648_15430 ENOG4105C2C drug resistance transporter, Bcr CflA CU648_15445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CU648_15450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CU648_15455 ENOG4105C3U ABC transporter CU648_15460 ENOG4108JQ7 (ABC) transporter CU648_15485 ENOG4105U5Y Transcriptional regulator CU648_15495 ENOG4108J59 Extracellular solute-binding protein, family 5 CU648_15500 ENOG4108J59 Extracellular solute-binding protein, family 5 CU648_15510 ENOG4105II7 pyrroline-5-carboxylate reductase CU648_15520 ENOG4107XDY Nicotinamide Mononucleotide Transporter CU648_15535 ENOG4105E0C molybdate abc transporter CU648_15540 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CU648_15545 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CU648_15580 ENOG4105F6E Acyl-transferase CU648_15605 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CU648_15630 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CU648_15655 ENOG4105C5H ABC transporter CU648_15665 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CU648_15670 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CU648_15680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CU648_15685 ENOG4105C3U ABC transporter CU648_15690 ENOG4108JQ7 (ABC) transporter CU648_15695 ENOG410667J hydrolase CU648_15730 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CU648_15735 ENOG4105ERH Fumarylacetoacetate hydrolase CU648_15750 ENOG4105CUB amino acid CU648_15755 ENOG4108SC4 )-transporter CU648_15760 ENOG4105CPF Cell wall formation (By similarity) CU648_15765 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CU648_15780 ENOG4107ZXI Rhomboid family CU648_15790 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CU648_15795 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CU648_15805 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CU648_15905 ENOG4105K8N protein family UPF0079, ATPase CU648_15910 ENOG41072GX Peptidase M22 Glycoprotease CU648_15915 ENOG410801F ribosomal-protein-alanine acetyltransferase CU648_15925 ENOG4105C5H ABC transporter CU648_15940 ENOG4108TYN CAAX amino terminal protease family protein CU648_15955 ENOG4107QJE Chromosome Partitioning Protein CU648_15975 ENOG4105C7N Xanthine uracil vitamin C permease CU648_15985 ENOG4105BZU Histidine kinase CU648_16010 ENOG4107ZXU DSBA oxidoreductase CU648_16055 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CU648_16075 ENOG4105SX7 Transporter CU648_16105 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CU648_16110 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CU648_16115 ENOG4105C83 adenylosuccinate lyase CU648_16125 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CU648_16150 ENOG4108V3E phosphoribosylglycinamide formyltransferase CU648_16160 ENOG4105C12 Phosphoribosylglycinamide synthetase CU648_16190 ENOG4105C4R Atp-dependent dna helicase CU648_16220 ENOG4108W2Y isochorismatase CU648_16230 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CU648_16235 ENOG4108UMI ABC transporter, permease CU648_16240 ENOG4105D01 (LipO)protein CU648_16260 ENOG410834F Transcriptional regulator CU648_16265 ENOG4107I77 yiaA/B two helix domain CU648_16285 ENOG4105CBD Diacylglycerol kinase CU648_16290 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CU648_16295 ENOG4108JPW Aminotransferase CU648_16305 ENOG4105C26 Dehydrogenase CU648_16310 ENOG4105KPY Small multidrug resistance protein CU648_16330 ENOG4105D9N nucleoside CU648_16335 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CU648_16345 ENOG4105BZU Histidine kinase CU648_16350 ENOG4108W15 Protein of unknown function (DUF1456) CU648_16365 ENOG4105DTQ mandelate racemase muconate lactonizing CU648_16375 ENOG4105DFD Na H antiporter CU648_16395 ENOG4105D3R alkyl hydroperoxide reductase CU648_16400 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CU648_16410 ENOG4107W7X Aldolase CU648_16415 ENOG4105EHG Permease protein CU648_16420 ENOG4105DQ5 transport system permease protein CU648_16425 ENOG4108V5C ABC transporter CU648_16455 ENOG4106UIA CU648_16460 ENOG4106UIA CU648_16490 ENOG4105BZU Histidine kinase CU648_16510 ENOG410756H nucleotidyltransferase CU648_16515 ENOG4105D2S major facilitator superfamily CU648_16530 ENOG4107QJZ Glycosyl transferase, family 2 CU648_16540 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CU648_16545 ENOG4105E5Q amino acid AbC transporter CU648_16550 ENOG4105EAB amino acid AbC transporter CU648_16565 ENOG4105C8Q Methyl-accepting chemotaxis CU648_16570 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CU648_16580 ENOG4105CI1 PTS System CU648_16610 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CU648_16625 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CU648_16645 ENOG4105C5H ABC transporter CU648_16675 ENOG41062JF Transcriptional regulator CU648_16695 ENOG4105DEU major facilitator superfamily CU648_16725 ENOG4108N0M stress protein CU648_16730 ENOG4106FN3 tellurium resistance protein CU648_16735 ENOG4106FN3 tellurium resistance protein CU648_16740 ENOG4107TS3 membrane protein, TerC CU648_16745 ENOG4108TTB tellurium resistance protein CU648_16765 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CU648_16775 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CU648_16800 ENOG4105KJF protein tyrosine phosphatase CU648_16810 ENOG4107U9T Pfam:Ribonuclease_BN CU648_16820 ENOG4105C59 p-type ATPase CU648_16825 ENOG4108IPJ Membrane CU648_16835 ENOG4105C3F Signal peptidase i CU648_16845 ENOG4107ZTW SNARE associated Golgi CU648_16860 ENOG410606W general stress protein CU648_16865 ENOG4105UPD Calcium Proton CU648_16900 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CU648_16905 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CU648_16915 ENOG4108JUB Transcriptional regulator CU648_16925 ENOG4108IQI permease CU648_16960 ENOG4105CSV Glutaminase CU648_16975 ENOG4108A04 Beta-lactamase CU648_16995 ENOG4105CKK Glycosyl transferase, family 2 CU648_17000 ENOG4107QQG Dehydrogenase CU648_17005 ENOG4105C3I Nad-dependent epimerase dehydratase CU648_17025 ENOG4105F1A Pyruvate formate-lyase CU648_17045 ENOG4105CI2 imidazolone-5-propionate hydrolase CU648_17050 ENOG4105ECP epimerase CU648_17080 ENOG41067AE Membrane-bound metal-dependent hydrolase CU648_17085 ENOG4105CEN a g-specific adenine glycosylase CU648_17090 ENOG4106BXE CU648_17110 ENOG4105BZ1 (ABC) transporter CU648_17115 ENOG4107NBY Membrane CU648_17120 ENOG4105CBC glutamate synthase CU648_17130 ENOG4108IUW ABC transporter CU648_17150 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CU648_17155 ENOG4105G5W regulator Fur family CU648_17260 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CU648_17280 ENOG4105EFC phage portal protein HK97 family CU648_17305 ENOG4108NE4 CU648_17380 ENOG4108JQC penicillin-binding protein 1A CU648_17385 ENOG4107ZQN disulfide bond CU648_17395 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CU648_17405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CU648_17410 ENOG4105BZU Histidine kinase CU648_17420 ENOG4105CYN Serine protein kinase CU648_17450 ENOG4105CT1 (ABC) transporter CU648_17455 ENOG4105CDA abc transporter atp-binding protein CU648_17460 ENOG4105DRP amino acid AbC transporter CU648_17465 ENOG4105DRP amino acid AbC transporter CU648_17470 ENOG4105C94 Transporter CU648_17485 ENOG4105DZ6 Band 7 protein CU648_17495 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CU648_17500 ENOG4108V9W transcriptional regulatory protein CU648_17505 ENOG4105D4T Citrate transporter CU648_17525 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CU648_17530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CU648_17535 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CU648_17540 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CU648_17545 ENOG4105BZ7 extracellular solute-binding protein family 1 CU648_17550 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CU648_17555 ENOG4108STX response regulator CU648_17560 ENOG4105US7 Histidine kinase CU648_17585 ENOG4108MRH transcriptional regulatory protein CU648_17595 ENOG4105C6K Malic enzyme CU648_17605 ENOG4108UZ3 Transporter CU648_17610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CU648_17620 ENOG4105BZU Histidine kinase CU648_17625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_17635 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CU648_17640 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CU648_17645 ENOG4108JB9 formate dehydrogenase CU648_17665 ENOG4105CUB amino acid CU648_17680 ENOG4105C59 p-type ATPase CU648_17685 ENOG4105DAP Nicotinate phosphoribosyltransferase CU648_17715 ENOG41073R8 VanW family CU648_17720 ENOG4108KGH TRANSCRIPTIONal CU648_17725 ENOG4105D9N nucleoside CU648_17730 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CU648_17735 ENOG4105C37 (CBS) domain CU648_17740 ENOG4108IJ0 Aspartate ammonia-lyase CU648_17745 ENOG4105DAA L-lactate CU648_17760 ENOG4105DUX Transporter CU648_17765 ENOG4108MES Periplasmic binding protein CU648_17770 ENOG4105DQ5 transport system permease protein CU648_17775 ENOG4108IHU transport system permease protein CU648_17780 ENOG4105E0A ABC, transporter CU648_17795 ENOG4105EXW epimerase dehydratase CU648_17805 ENOG4107T89 von Willebrand factor, type A CU648_17810 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CU648_17815 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CU648_17830 ENOG4105BZU Histidine kinase CU648_17835 ENOG4105D5Q Arginine ornithine antiporter CU648_17840 ENOG4107414 GntR family transcriptional regulator CU648_17845 ENOG4105C5Y PTS System CU648_17850 ENOG4105CG3 alpha amylase, catalytic region CU648_17865 ENOG4105E1K spore germination protein CU648_17875 ENOG4105CRN Aminoglycoside phosphotransferase CU648_17880 ENOG4105BZG amino acid carrier protein CU648_17885 ENOG4105CDA abc transporter atp-binding protein CU648_17890 ENOG4105CT1 (ABC) transporter CU648_17895 ENOG4105EAD ABC transporter CU648_17900 ENOG4105DRP amino acid AbC transporter CU648_17905 ENOG4108IQI permease CU648_17930 ENOG4105D29 Helix-turn-helix type 11 domain protein CU648_17935 ENOG4105NAE bifunctional deaminase-reductase domain protein CU648_17940 ENOG4105BZU Histidine kinase CU648_17955 ENOG4105CHH sulfate transporter CU648_17960 ENOG41068KF Universal stress protein CU648_17970 ENOG4105DEF Extracellular solute-binding protein, family 5 CU648_17980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CU648_17985 ENOG4108JQ7 (ABC) transporter CU648_17995 ENOG4105CXY transporter CU648_18000 ENOG41067TZ transcriptional regulator, MarR family CU648_18005 ENOG4105C0R drug resistance transporter emrb qaca subfamily CU648_18010 ENOG4105ETE Transcriptional regulator (LacI family CU648_18015 ENOG4108RVA ribokinase CU648_18025 ENOG4105C2J ABC transporter CU648_18030 ENOG4105CNN ABC, transporter CU648_18035 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CU648_18040 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CU648_18105 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CU648_18110 ENOG41069ER domain protein CU648_18115 ENOG4105VZ8 Transcriptional regulator CU648_18120 ENOG4107D63 CU648_18130 ENOG4105DUX Transporter CU648_18150 ENOG4105C85 amino acid CU648_18155 ENOG4105C7N Xanthine uracil vitamin C permease CU648_18170 ENOG4105MA6 gCN5-related N-acetyltransferase CU648_18195 ENOG4105BZ9 Cytochrome C oxidase, subunit I CU648_18200 ENOG4105E2S oxidase) subunit II CU648_18205 ENOG4108IQI permease CU648_18220 ENOG4106CAD Protein of unknown function (DUF3311) CU648_18225 ENOG4105E1V na solute symporter CU648_18240 ENOG4108NHD germination protein CU648_18250 ENOG4105CE1 Ferrous iron transport protein b CU648_18255 ENOG4105CE1 Ferrous iron transport protein b CU648_18260 ENOG4105CE1 Ferrous iron transport protein b CU648_18265 ENOG4105CVA phosphate CU648_18270 ENOG4105C8U phosphate abc transporter CU648_18275 ENOG4105E2Z phosphate ABC transporter (Permease CU648_18405 ENOG41080XQ Signal transduction protein with cbs domains CU648_18430 ENOG4105ETU transcriptional activator (TenA CU648_18440 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CU648_18450 ENOG4108VEU Thiamine monophosphate synthase CU648_18455 ENOG41080HI glycine oxidase CU648_18470 ENOG4105D06 uba thif-type nad fad binding protein CU648_18475 ENOG4105DWF phosphomethylpyrimidine kinase CU648_18530 ENOG4108INS Transcriptional regulator CU648_18555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CU648_18565 ENOG4105CNN ABC, transporter CU648_18570 ENOG4105C2J ABC transporter CU648_18575 ENOG4108QGH periplasmic CU648_18580 ENOG4105C7N Xanthine uracil vitamin C permease CU648_18590 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CU648_18625 ENOG4108B31 Spore germination protein CU648_18645 ENOG4107Y03 Nitroreductase CU648_18650 ENOG4105ED1 spovr family CU648_18655 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CU648_18660 ENOG4105XTG Pfam:DUF156 CU648_18665 ENOG4105VFE sira family CU648_18670 ENOG4107TPS domain protein CU648_18675 ENOG4105VFE sira family CU648_18685 ENOG4105VFE sira family CU648_18695 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CU648_18700 ENOG41087NI Sulfite exporter TauE/SafE CU648_18710 ENOG4108KGH TRANSCRIPTIONal CU648_18735 ENOG4105EMD TRANSCRIPTIONal CU648_18740 ENOG4105VCP PTS System CU648_18745 ENOG4105VZJ PTS System CU648_18770 ENOG41069ER domain protein CU648_18775 ENOG4107RBB ABC transporter, permease CU648_18780 ENOG4105C19 ABC transporter CU648_18815 ENOG4105WEF catalase CU648_18850 ENOG4107T5V SNARE associated Golgi CU648_18885 ENOG4105CUB amino acid CU648_18890 ENOG4107RWR Sodium hydrogen exchanger CU648_18900 ENOG4106KNT transcriptional regulator CU648_18940 ENOG4108YXU transcriptional regulator AsnC family CU648_18950 ENOG4105KPY Small multidrug resistance protein CU648_18955 ENOG4105KPY Small multidrug resistance protein CU648_18970 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CU648_18975 ENOG4105E5W Transporter CU648_18985 ENOG4107RKG DJ-1/PfpI family CU648_18990 ENOG4105CH6 catalase CU648_19000 ENOG4105D5Q Arginine ornithine antiporter CU648_19005 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CU648_19015 ENOG4105C26 Dehydrogenase CU648_19035 ENOG4105BZ1 (ABC) transporter CU648_19040 ENOG4105BZ1 (ABC) transporter CU648_19055 ENOG4105DRP amino acid AbC transporter CU648_19060 ENOG4105CDA abc transporter atp-binding protein CU648_19075 ENOG410839P CU648_19100 ENOG4105BZU Histidine kinase CU648_19150 ENOG4107FQX Alpha-acetolactate decarboxylase CU648_19175 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CU648_19185 ENOG4105D4P Coproporphyrinogen iii oxidase CU648_19205 ENOG4105CHH sulfate transporter CU648_19245 ENOG4106AKK s-layer domain-containing protein CU648_19255 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CU648_19265 ENOG4105CGU Enoyl-CoA hydratase CU648_19285 ENOG4105DER m42 family CU648_19305 ENOG4105CTU Proline racemase CU648_19315 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CU648_19320 ENOG41066A3 ATP guanido phosphotransferase CU648_19345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CU648_19355 ENOG4108JQ7 (ABC) transporter CU648_19365 ENOG4105CSH Transporter CU648_19375 ENOG4108MRH transcriptional regulatory protein CU648_19425 ENOG4105C4R Atp-dependent dna helicase CU648_19485 ENOG4105CDU Replicative dna helicase CU648_19585 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CU648_19620 ENOG4105CMT Dihydroxyacetone kinase CU648_19635 ENOG4105CMT Dihydroxyacetone kinase CU648_19640 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CU648_19645 ENOG410847I Transcriptional regulator, BadM Rrf2 family CU648_19695 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CU648_19710 ENOG4105FBW Monooxygenase CU648_19850 ENOG4105WN5 stage II sporulation protein CU648_19860 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CU648_19870 ENOG4108MJI response regulator CU648_19875 ENOG4105BZU Histidine kinase CU648_19880 ENOG4105BZU Histidine kinase CU648_19905 ENOG4105K8R UPF0145 protein CU648_19940 ENOG4107VRP DNA repair exonuclease CU648_19945 ENOG4106D4I domain protein CU648_19995 ENOG4108MUZ hydrolase CU648_20025 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CU648_20040 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CU648_20060 ENOG4105EMN RNA polymerase sigma factor CU648_20085 ENOG4105C57 major facilitator superfamily CU648_20090 ENOG4105C0R drug resistance transporter emrb qaca subfamily CU648_20100 ENOG4105EEM helicase CU648_20105 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CU648_20135 ENOG4105K59 histidine triad (HIT) protein CU648_20220 ENOG410905X membrane-flanked domain protein CU648_20225 ENOG4105CKV Membrane CU648_20265 ENOG410905X membrane-flanked domain protein CU648_20270 ENOG4105CKV Membrane CU648_20275 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CU648_20280 ENOG4105BZ4 penicillin-binding protein CU648_20295 ENOG4105C1Q protoporphyrinogen oxidase CU648_20330 ENOG4105ECB domain protein CU648_20350 ENOG4108MK9 spermidine N(1)-acetyltransferase CU648_20360 ENOG4106AXD CU648_20365 ENOG4108RQ5 Beta-lactamase domain-containing protein CU648_20370 ENOG4105DF9 Lipoate-protein, ligase CU648_20380 ENOG4105CEY Amp-dependent synthetase and ligase CU648_20410 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CU648_20415 ENOG4107RN3 metallophosphoesterase CU648_20425 ENOG4107TVP HD domain protein CU648_20430 ENOG4108JJB ABC transporter CU648_20450 ENOG4107YPT transcriptional regulator CU648_20455 ENOG4105C57 major facilitator superfamily CU648_20465 ENOG4108AEY RNA polymerase sigma factor CU648_20470 ENOG41086D8 Transcriptional regulator CU648_20490 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CU648_20515 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CU648_20535 ENOG4105ZU5 s-layer protein CU648_20540 ENOG4107QP3 malate synthase g CU648_20555 ENOG4105VEQ Cold shock protein CU648_20570 ENOG4105XVF Competence transcription factor CU648_20635 ENOG4105ERH Fumarylacetoacetate hydrolase CU648_20660 ENOG4105CAQ asparagine synthetase CU648_20670 ENOG4105CH6 catalase CU648_20675 ENOG4105BZU Histidine kinase CU648_20695 ENOG4105QNR S1 RNA binding domain protein CU648_20700 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CU648_20710 ENOG4107AYK membrAne CU648_20715 ENOG41073B9 CU648_20725 ENOG4108KP7 hydrolase CU648_20740 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CU648_20770 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CU648_20775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CU648_20795 ENOG4105C31 Tryptophanyl-tRNA synthetase CU648_20815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CU648_20820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CU648_20830 ENOG4108JQ7 (ABC) transporter CU648_20835 ENOG4105UQX Mate efflux family protein CU648_20870 ENOG4108ZCF integral membrane protein CU648_20880 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CU648_20890 ENOG4105DPN Oligoendopeptidase f CU648_20905 ENOG4108Z18 K06886 hemoglobin CU648_20910 ENOG4105MIX Adenylate cyclase CU648_20925 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CU648_20930 ENOG4105EMS pseudouridine synthase CU648_20950 ENOG4105K64 Glycosyl transferase, family 2 CU648_20970 ENOG4107TVC Glycosyl transferase, family 2 CU648_20990 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CU648_20995 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CU648_21005 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CU648_21080 ENOG4105CK7 Sodium proline symporter CU648_21090 ENOG4105CRQ synthase (Component I) CU648_21095 ENOG4105DDQ anthranilate synthase CU648_21195 ENOG4105C7S Dehydrogenase CU648_21205 ENOG4105VZ8 Transcriptional regulator CU648_21295 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CU648_21310 ENOG4105DZ1 carboxypeptidase CU648_21315 ENOG4105VFR signal peptidase CU648_21350 ENOG4105C26 Dehydrogenase CU648_21360 ENOG4105F38 ABC transporter, permease CU648_21365 ENOG4105D38 putrescine abc transporter CU648_21370 ENOG4107RUE extracellular solute-binding protein family 1 CU648_21380 ENOG4105EYF MMPL domain protein CU648_21390 ENOG4108YBP pseudouridine synthase CU648_21400 ENOG4105K4I Scp-like extracellular CU648_21405 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CU648_21410 ENOG4105CQB FAD linked oxidase domain protein CU648_21425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_21430 ENOG4105BZU Histidine kinase CU648_21435 ENOG4105JXH GntR family transcriptional regulator CU648_21455 ENOG4106A3R peptidase CU648_21465 ENOG4108QTI )-transporter CU648_21470 ENOG4107TS3 membrane protein, TerC CU648_21475 ENOG4105CZN Potassium uptake protein CU648_21480 ENOG410681C small acid-soluble spore protein CU648_21485 ENOG4108Z7G MaoC domain protein dehydratase CU648_21505 ENOG4105CHR reductase CU648_21515 ENOG4105MWK D-amino acid dehydrogenase, small subunit CU648_21540 ENOG4105C4Y ABC transporter CU648_21545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CU648_21550 ENOG4107RCV ABC transporter, permease CU648_21570 ENOG4105E98 transcriptional regulator DeoR family CU648_21585 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CU648_21595 ENOG4105PXI polysaccharide deacetylase CU648_21605 ENOG4105BZU Histidine kinase CU648_21610 ENOG41090MY MarR family Transcriptional regulator CU648_21620 ENOG4106DF1 CU648_21630 ENOG4105BZU Histidine kinase CU648_21640 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CU648_21645 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CU648_21690 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CU648_21700 ENOG41079K6 HNH endonuclease CU648_21710 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CU648_21715 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CU648_21720 ENOG4105CZV ABC transporter CU648_21730 ENOG4105CJ1 ABC, transporter CU648_21770 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CU648_21775 ENOG4105EA8 2-Nitropropane dioxygenase CU648_21780 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CU648_21790 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CU648_21815 ENOG4105NQC Flavodoxin CU648_21855 ENOG4107QMU Mate efflux family protein CU648_21860 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CU648_21890 ENOG4105CZN Potassium uptake protein CU648_21895 ENOG41063Y9 CU648_21900 ENOG4105KBJ sporulation protein ytfj CU648_21930 ENOG4105CM2 brancheD-chain amino acid aminotransferase CU648_21935 ENOG4105C7K acetolactate synthase CU648_21940 ENOG4108ZP8 Acetolactate synthase small subunit CU648_21980 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CU648_22015 ENOG4107RVV histidinol phosphate phosphatase, hisj family CU648_22030 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CU648_22035 ENOG4105E0M Sulfatase CU648_22045 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CU648_22065 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CU648_22070 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CU648_22080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CU648_22085 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CU648_22090 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CU648_22100 ENOG4105C8J )-transporter CU648_22120 ENOG4105DFD Na H antiporter CU648_22140 ENOG4105ENE Histidine kinase CU648_22145 ENOG4105WH1 Two component transcriptional regulator luxr family CU648_22165 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CU648_22215 ENOG4105CJ3 phosphate transporter CU648_22220 ENOG4107GRR phosphate transport regulator CU648_22225 ENOG4105BZ4 penicillin-binding protein CU648_22240 ENOG4105BZU Histidine kinase CU648_22245 ENOG4105I3N Conserved Protein CU648_22260 ENOG4105BZU Histidine kinase CU648_22290 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CU648_22295 ENOG4105DZ1 carboxypeptidase CU648_22300 ENOG4108JIC nucleoside recognition domain protein CU648_22310 ENOG4105FE9 pseudouridine synthase CU648_22320 ENOG4107TWT Cytochrome c biogenesis protein CU648_22325 ENOG4105CRE cytochrome C CU648_22330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_22335 ENOG4105BZU Histidine kinase CU648_22340 ENOG4108WBT adenosyltransferase CU648_22345 ENOG41063SB peptidase CU648_22355 ENOG4108SAX Membrane CU648_22370 ENOG4105C9U ATP-dependent DNA helicase RecQ CU648_22375 ENOG4105I7S Abortive infection protein CU648_22385 ENOG4107RGJ metallophosphoesterase CU648_22390 ENOG4107X2D transcriptional regulator, merr family CU648_22395 ENOG4108S6Z Negative regulator of genetic competence CU648_22420 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CU648_22425 ENOG4105HDK L-asparaginase CU648_22460 ENOG4105S2F CU648_22465 ENOG41065D1 CU648_22495 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CU648_22510 ENOG4105XXQ heptaprenyl diphosphate synthase component I CU648_22520 ENOG4105EAH synthase CU648_22545 ENOG41068YB TPR repeat-containing protein CU648_22560 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CU648_22565 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CU648_22570 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit CU648_22605 ENOG4108JYZ YitT family CU648_22615 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CU648_22630 ENOG4105FJR Lmbe family CU648_22635 ENOG4105CPK Glycosyl transferase (Group 1 CU648_22675 ENOG4105DVT helicase CU648_22680 ENOG4105YAC CU648_22700 ENOG4105CSM endonuclease III CU648_22710 ENOG4105BZ4 penicillin-binding protein CU648_22770 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CU648_22780 ENOG4105DVT helicase CU648_22785 ENOG4105CTD carboxy-peptidase CU648_22800 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CU648_22810 ENOG4105C2W permease CU648_22815 ENOG4105DHF Membrane CU648_22825 ENOG410890F Dynamin family CU648_22835 ENOG4108W0I acetyltransferase CU648_22845 ENOG4105KHC sulfurtransferase CU648_22880 ENOG4106032 Glutathionylspermidine synthase CU648_22910 ENOG4108SZE gCN5-related N-acetyltransferase CU648_22930 ENOG41081VK Ribonuclease CU648_22995 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CU648_23010 ENOG4107RWR Sodium hydrogen exchanger CU648_23015 ENOG4105CN5 Metallo-Beta-Lactamase CU648_23030 ENOG4105ESI atpase involved in dna repair CU648_23065 ENOG41085FC arsR family transcriptional regulator CU648_23070 ENOG4105CAY ferredoxin--nadp reductase CU648_23090 ENOG41082YX Transcriptional regulator, arsr family CU648_23095 ENOG4105D6J arsenicaL-resistance protein CU648_23125 ENOG4108Z5V transcriptional regulator, merr family CU648_23135 ENOG4105H67 Protein of unknown function (DUF421) CU648_23140 ENOG41080C8 DUF218 domain CU648_23195 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CU648_23205 ENOG4107R0U MotA TolQ exbB proton channel CU648_23210 ENOG4105ER2 Ompa motb domain protein CU648_23215 ENOG4107YTP response regulator receiver protein CU648_23220 ENOG4105CBS Chea signal transduction histidine kinase CU648_23225 ENOG4105DD5 Flagellar motor switch protein CU648_23240 ENOG4105BZU Histidine kinase CU648_23260 ENOG4105E1Q flagellar hook-associated protein CU648_23265 ENOG4105DTJ flagellar hook-associated protein CU648_23270 ENOG4105DTS flagellar hook-associated CU648_23285 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CU648_23290 ENOG4108ZC9 flagellar basal-body rod protein flgc CU648_23295 ENOG41075Z6 flagellar hook-basal body complex protein fliE CU648_23300 ENOG4107U2N Flagellar M-ring protein CU648_23305 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CU648_23335 ENOG4105BZE flagellar hook protein, FlgE CU648_23350 ENOG4107R88 Chemotaxis protein (CheV) CU648_23360 ENOG4105I03 Flagellin CU648_23365 ENOG4105I03 Flagellin CU648_23365 ENOG4105I03 Flagellin CU648_23370 ENOG4105E4C Lytic transglycosylase catalytic CU648_23380 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CU648_23385 ENOG4105DD5 Flagellar motor switch protein CU648_23395 ENOG4105CN7 Flagellar biosynthetic protein FliP CU648_23400 ENOG4105VS8 Flagellar biosynthetic protein fliq CU648_23410 ENOG4105D00 flagellar biosynthetic protein flhB CU648_23415 ENOG4105D7B Flagellar biosynthesis protein flha CU648_23420 ENOG4105FZW flagellar biosynthesis regulator FlhF CU648_23425 ENOG4105KTQ flagellar basal-body rod protein CU648_23430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CU648_23455 ENOG4108RZE Tetr family transcriptional regulator CU648_23485 ENOG4105KAC Antibiotic biosynthesis monooxygenase CU648_23510 ENOG4105DUM transcriptional regulator, lysR family CU648_23515 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CU648_23520 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CU648_23525 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component CU648_23530 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CU648_23565 ENOG4105CVJ phosphoglycerate mutase CU648_23580 ENOG4105K56 Transcriptional regulator CU648_23590 ENOG4105CAQ asparagine synthetase CU648_23610 ENOG4105PGM cation diffusion facilitator family transporter CU648_23620 ENOG4105DRR Transcriptional regulator, GntR family CU648_23625 ENOG4108UZ3 Transporter CU648_23630 ENOG4105CKI cobalamin synthesis protein CU648_23640 ENOG4108PJD permease CU648_23655 ENOG4105DFD Na H antiporter CU648_23660 ENOG4105C9Q fumarate hydratase class II CU648_23675 ENOG4105C5X domain protein CU648_23685 ENOG4107QJQ Mate efflux family protein CU648_23695 ENOG4105EC3 peptidase S51, dipeptidase E CU648_23715 ENOG4107QIV Cytochrome c biogenesis protein CU648_23745 ENOG4106BRA Membrane CU648_23785 ENOG4105CJ1 ABC, transporter CU648_23805 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CU648_23815 ENOG4108IJ0 Aspartate ammonia-lyase CU648_23820 ENOG4105C6K Malic enzyme CU648_23860 ENOG41067QW Transcriptional regulator CU648_23890 ENOG4105FVX CU648_23930 ENOG4105CSR polyphosphate kinase 2 CU648_23935 ENOG4105U3E Transcriptional regulator CU648_23945 ENOG4105DXI Major Facilitator superfamily CU648_23960 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CU648_23970 ENOG4105EU0 Major facilitator Superfamily CU648_23975 ENOG4105C6T cysteine synthase CU648_23995 ENOG4105C8J )-transporter CU648_24005 ENOG4105X5K response regulator receiver protein CU648_24010 ENOG4105H67 Protein of unknown function (DUF421) CU648_24035 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CU648_24040 ENOG4105E3B Multicopper oxidase CU648_24050 ENOG4105BZU Histidine kinase CU648_24055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_24060 ENOG4105CHR reductase CU648_24065 ENOG4105CM2 brancheD-chain amino acid aminotransferase CU648_24070 ENOG4105C7K acetolactate synthase CU648_24075 ENOG4108ZP8 Acetolactate synthase small subunit CU648_24080 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CU648_24090 ENOG4105C7B Threonine dehydratase CU648_24115 ENOG4105C6X Major Facilitator CU648_24120 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CU648_24130 ENOG4105DY9 regulatoR CU648_24135 ENOG4105CYC Transferase CU648_24155 ENOG4108IBT Inherit from COG: transposase CU648_24220 ENOG41068WN CU648_24240 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CU648_24245 ENOG4105C72 UPF0176 protein CU648_24275 ENOG4105C0X amino acid CU648_24310 ENOG4107RHR regulatoR CU648_24320 ENOG4105D9N nucleoside CU648_24325 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CU648_24360 ENOG4107RAQ aminopeptidase CU648_24365 ENOG4107R16 Multicopper oxidase CU648_24430 ENOG4108T5E Copper resistance protein CU648_24435 ENOG4105KTB nuclear export factor GLE1 CU648_24445 ENOG4107RT3 EamA-like transporter family CU648_24450 ENOG4105GZI Transcriptional regulator CU648_24455 ENOG4108Z40 Transcriptional regulator CU648_24460 ENOG4107ZXU DSBA oxidoreductase CU648_24465 ENOG4108TVJ Nitroreductase CU648_24475 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CU648_24480 ENOG4106F5Q Membrane CU648_24485 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CU648_24495 ENOG4105CKI cobalamin synthesis protein CU648_24515 ENOG4108Z7G MaoC domain protein dehydratase CU648_24520 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CU648_24535 ENOG4105C0Z ABC transporter CU648_24540 ENOG4108IV0 ABC, transporter CU648_24545 ENOG4105C32 Amino acid ABC transporter (Permease) CU648_24555 ENOG4105SKE transcriptional Regulator LysR family CU648_24565 ENOG4105MDS 4-oxalocrotonate tautomerase CU648_24585 ENOG4105C4M (Ubiquinol oxidase) subunit I CU648_24590 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CU648_24595 ENOG4108JJ9 ABC, transporter CU648_24600 ENOG4108JJ8 (ABC) transporter CU648_24645 ENOG4105BZ1 (ABC) transporter CU648_24650 ENOG4105EFI regulatoR CU648_24655 ENOG4105BZU Histidine kinase CU648_24675 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CU648_24680 ENOG4108ZJ4 polysaccharide deacetylase CU648_24685 ENOG4106AKJ CU648_24705 ENOG4105D6E homoserine dehydrogenase CU648_24730 ENOG4108KGH TRANSCRIPTIONal CU648_24740 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CU648_24745 ENOG4105BZU Histidine kinase CU648_24750 ENOG4107VMI polysaccharide deacetylase CU648_24760 ENOG4105KT7 mgtC SapB transporter CU648_24765 ENOG4105VRR gCN5-related N-acetyltransferase CU648_24775 ENOG4105DUU IucA IucC family protein CU648_24780 ENOG4105CEY Amp-dependent synthetase and ligase CU648_24795 ENOG4108WBH protein TIM barrel CU648_24800 ENOG4105YWU small acid-soluble spore protein CU648_24810 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CU648_24865 ENOG4105KRN Transcriptional regulator, abrb family CU648_24875 ENOG4105YVS arsR family transcriptional regulator CU648_24880 ENOG4107SET aldo keto reductase CU648_24885 ENOG4107XZQ multidrug resistance protein CU648_24910 ENOG4105C8Q Methyl-accepting chemotaxis CU648_24930 ENOG4108K88 Membrane CU648_24935 ENOG4108WPJ Ferritin-like domain CU648_24950 ENOG4105DEN Luciferase family CU648_24970 ENOG4107QM2 Aldo Keto reductase CU648_24975 ENOG4105CKI cobalamin synthesis protein CU648_24990 ENOG4108IBT Inherit from COG: transposase CU648_24995 ENOG4105DSE periplasmic solute binding protein CU648_25005 ENOG4105K4T epimerase CU648_25015 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CU648_25040 ENOG4107TB6 phosphoglycerate mutase CU648_25060 ENOG4107T5V SNARE associated Golgi CU648_25075 ENOG4108PJD permease CU648_25085 ENOG4108S4H thioesterase Superfamily protein CU648_25095 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CU648_25115 ENOG4105SXS Protein of unknown function (DUF456) CU648_25120 ENOG4105C37 (CBS) domain CU648_25140 ENOG4108Z7R Chaperone CsaA CU648_25160 ENOG4108ZRV stage ii sporulation protein p CU648_25170 ENOG4108VXD carboxy-peptidase CU648_25180 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CU648_25205 ENOG4108X4Q Hydrolase CU648_25215 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CU648_25220 ENOG4107UWY Methyltransferase CU648_25235 ENOG41087PP glycosyltransferase MGT family CU648_25240 ENOG4108JYZ YitT family CU648_25245 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CU648_25275 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CU648_25310 ENOG4105KBJ sporulation protein ytfj CU648_25335 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CU648_25355 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CU648_25360 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CU648_25370 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CU648_25375 ENOG4105EMN RNA polymerase sigma factor CU648_25410 ENOG4108V06 Glutathione peroxidase CU648_25425 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CU648_25445 ENOG4108IUE nitrate reductase beta subunit CU648_25450 ENOG4105R3A Nitrate reductase CU648_25460 ENOG4107V6Q Cyclic nucleotide-binding domain CU648_25465 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CU648_25470 ENOG4105D06 uba thif-type nad fad binding protein CU648_25475 ENOG4105CVM Molybdenum cofactor synthesis domain protein CU648_25480 ENOG4108ZAF Molybdopterin CU648_25500 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CU648_25505 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CU648_25510 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CU648_25515 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CU648_25520 ENOG4108IFG nitrite reductase, (NAD(P)H) CU648_25525 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CU648_25550 ENOG4105MCT stage V sporulation protein S CU648_25600 ENOG4105C5H ABC transporter CU648_25615 ENOG4108UUM single-stranded DNA-binding protein CU648_25635 ENOG4107YX5 Pfam:DUF548 CU648_25675 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CU648_25685 ENOG4105C5S asparaginyl-tRNA synthetase CU648_25705 ENOG4105EC2 ftsk spoIIIe CU648_25760 ENOG4105BZW Glycerate kinase CU648_25765 ENOG4107QPK )-transporter CU648_25770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CU648_25775 ENOG41062D9 Histidine kinase CU648_25790 ENOG4105C8J )-transporter CU648_25810 ENOG4107XGZ Hydrolase CU648_25815 ENOG4105CY2 Citrate transporter CU648_25820 ENOG4105C0A alcohol dehydrogenase CU648_25835 ENOG4105KD7 acetyltransferase CU648_25840 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CU648_25865 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 CU648_25885 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CU648_25895 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CU648_25905 ENOG4107RVG penicillin-binding protein CU648_25915 ENOG4105E9Q Acyl-transferase CU648_25920 ENOG4108UT2 hemolysin iii CU648_25930 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CU648_25945 ENOG4108RCR degv family CU648_25950 ENOG4107T8T UPF0173 metal-dependent hydrolase CU648_25955 ENOG4108KF3 Electron transport protein SCO1 SenC CU648_25960 ENOG4107Y70 Heat shock protein CU648_25965 ENOG4105CAQ asparagine synthetase CU648_25990 ENOG4108MES Periplasmic binding protein CU648_25995 ENOG4105F0I Aminotransferase CU648_26025 ENOG4107Y70 Heat shock protein CU648_26030 ENOG4105D8X mechanosensitive ion channel CU648_26035 ENOG4105BZU Histidine kinase CU648_26040 ENOG4105WH1 Two component transcriptional regulator luxr family CU648_26075 ENOG4105CMG Carbohydrate kinase CU648_26080 ENOG4105CMG Carbohydrate kinase CU648_26110 ENOG4108IJ8 ABC transporter CU648_26115 ENOG4105E90 ABC transporter CU648_26150 ENOG4105C37 (CBS) domain CU648_26180 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CU648_26195 ENOG4107S4Y M20 DapE family protein YgeY CU648_26200 ENOG4108TSC N-acetyltransferase CU648_26205 ENOG4108JUB Transcriptional regulator CU648_26215 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CU648_26255 ENOG4108N23 SpoOM-related protein CU648_26260 ENOG410841Q phosphoesterase PA-phosphatase related protein CU648_26270 ENOG4105SZ6 Thioredoxin CU648_26350 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CU648_26405 ENOG4105BZ4 penicillin-binding protein CU648_26410 ENOG4105CZM Major Facilitator CU648_26415 ENOG4105W8X HesB YadR YfhF-family protein CU648_26425 ENOG4105DXD 2-methylcitrate dehydratase CU648_26430 ENOG4105CR4 methylisocitrate lyase CU648_26435 ENOG4105C1G acyl-Coa dehydrogenase CU648_26440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CU648_26450 ENOG4105N14 lysine exporter protein LysE YggA CU648_26455 ENOG4105E39 Enoyl-CoA hydratase CU648_26470 ENOG4107RFY SbcCD D subunit CU648_26475 ENOG4105EYH Exonuclease CU648_26505 ENOG4105FCD Major Facilitator CU648_26515 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CU648_26520 ENOG4105E4F Isochorismate synthase CU648_26525 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CU648_26530 ENOG4105WQI isochorismatase CU648_26535 ENOG4105CEY Amp-dependent synthetase and ligase CU648_26540 ENOG4105WQT MbtH domain protein CU648_26545 ENOG4105C0R drug resistance transporter emrb qaca subfamily CU648_26560 ENOG4105K70 DNA-binding protein CU648_26580 ENOG4105BZG amino acid carrier protein CU648_26600 ENOG4105FE9 pseudouridine synthase CU648_26605 ENOG4105C22 threonyL-tRNA synthetase CU648_26610 ENOG4105C19 ABC transporter CU648_26625 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CU648_26650 ENOG4108D32 Methyltransferase CU648_26670 ENOG41081I9 integral membrane protein CU648_26685 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CU648_26695 ENOG4105EYF MMPL domain protein CU648_26720 ENOG4105WCN acetyltransferase CU648_26730 ENOG41085FC arsR family transcriptional regulator CU648_26735 ENOG4105CAY ferredoxin--nadp reductase CU648_26750 ENOG4105CN5 Metallo-Beta-Lactamase CU648_26755 ENOG4107YZX Universal stress protein CU648_26760 ENOG4105CHH sulfate transporter CU648_26770 ENOG4105VUN Transcriptional regulator CU648_26780 ENOG41082YX Transcriptional regulator, arsr family CU648_26785 ENOG4105D6J arsenicaL-resistance protein CU648_26855 ENOG4105C1Q protoporphyrinogen oxidase CU648_26865 ENOG41089UC methyltransferase, type 11 CU648_26870 ENOG41068WN CU648_26880 ENOG4105VEQ Cold shock protein CU648_26905 ENOG4107V2S Transcriptional regulator CU648_26910 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CU648_26925 ENOG4105DND Transcriptional regulator CU648_26930 ENOG4108RPX mosc domain containing protein CU648_26945 ENOG4105BZ1 (ABC) transporter CU648_26950 ENOG4105BZ1 (ABC) transporter CU648_26970 ENOG4108JCI Transcriptional regulator CU648_27000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CU648_27015 ENOG4108KPJ rna polymerase sigma factor CU648_27045 ENOG4105F32 YngK protein CU648_27075 ENOG4105RD7 BadF BadG BcrA BcrD CU648_27085 ENOG4107STF Involved in phosphonate degradation (By similarity) CU648_27150 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CU648_27165 ENOG4105C1J atp-dependent rna helicase CU648_27180 ENOG4108RZE Tetr family transcriptional regulator CU648_27200 ENOG41088CC tellurite resistance protein tehB CU648_27210 ENOG4107RA9 decarboxylase CU648_27215 ENOG41090HR transcriptional regulator CU648_27250 ENOG4105CIN aminoacyl-histidine dipeptidase CU648_27275 ENOG4107RF6 penicillin-binding protein CU648_27280 ENOG4107RF6 penicillin-binding protein CU648_27290 ENOG4105DIN metallophosphoesterase CU648_27325 ENOG4105C1G acyl-Coa dehydrogenase CU648_27330 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CU648_27335 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CU648_27340 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CU648_27345 ENOG4105E39 Enoyl-CoA hydratase CU648_27350 ENOG4107QX3 carboxylase CU648_27355 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CU648_27365 ENOG4105WCN acetyltransferase CU648_27370 ENOG4105DBI uridine monophosphokinase CU648_27380 ENOG4105DZ1 carboxypeptidase CU648_27395 ENOG4105T9C HD domain CU648_27405 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CU648_27445 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CU648_27445 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CU648_27460 ENOG4105FQP Beta-lactamase CU648_27490 ENOG4105CUV Homoserine Kinase CU648_27530 ENOG4105CPQ Dehydrogenase CU648_27555 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CU648_27645 ENOG4105ETU transcriptional activator (TenA CU648_27780 ENOG410667J hydrolase CU648_27815 ENOG4105BZU Histidine kinase CU648_27820 ENOG4107RF6 penicillin-binding protein CU648_27855 ENOG4108HGU Histidine kinase CU648_27865 ENOG4105RHY Pfam:UPF0157 CU648_27870 ENOG4105CB2 alcohol dehydrogenase CU648_27875 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CU648_27880 ENOG4105CJN penicillin-binding protein CU648_27895 ENOG4105FQP Beta-lactamase CU648_27930 ENOG4108V4B ThiJ pfpI CU648_27960 ENOG4107Y80 Major Facilitator superfamily CU648_27980 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CU648_28005 ENOG4107Y9U Membrane CU648_28035 ENOG4105FCD Major Facilitator CU648_28040 ENOG4105E09 nadh pyrophosphatase CU648_28045 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CU648_28050 ENOG4105E09 nadh pyrophosphatase CU648_28080 ENOG4108XI2 Domain of unknown function (DUF1963) CU648_28100 ENOG4108NRW Phospholipase, patatin family CU648_28105 ENOG4105KWG Pfam:DUF1696 CU648_28140 ENOG4105PKS Excinuclease abc c subunit domain protein CU648_28185 ENOG4107VFR oxidoreductase CU648_28210 ENOG4105U0R haloacid dehalogenase-like hydrolase CU648_28235 ENOG4108IUM Glycogen debranching enzyme CU648_28260 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)