locus-tag	class	description
CU648_00005	COG0697	spore germination
CU648_00010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_00050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_00065	COG2959	enzyme of heme biosynthesis
CU648_00070	COG3773	Cell wall hydrolase
CU648_00070	COG3409	Peptidoglycan-binding domain 1 protein
CU648_00090	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CU648_00100	COG1309	transcriptional regulator
CU648_00135	COG3284	Transcriptional regulator
CU648_00150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_00155	COG1349	DNA-binding transcription factor activity
CU648_00175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU648_00185	COG3328	transposase activity
CU648_00190	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_00195	COG0022	dehydrogenase e1 component
CU648_00200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU648_00210	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_00215	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU648_00215	COG0456	acetyltransferase
CU648_00255	COG4176	ABC-type proline glycine betaine transport system permease component
CU648_00260	COG0517	IMP dehydrogenase activity
CU648_00260	COG4175	Glycine betaine
CU648_00270	COG0740	serine-type endopeptidase activity
CU648_00285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CU648_00290	COG2153	protein acetylation
CU648_00295	COG3397	chitin binding
CU648_00310	COG2205	protein histidine kinase activity
CU648_00320	COG2315	Protein conserved in bacteria
CU648_00330	COG2333	competence protein COMEC
CU648_00330	COG0658	competence protein
CU648_00380	COG3973	AAA domain
CU648_00400	COG0514	ATP-dependent DNA helicase (RecQ)
CU648_00435	COG4637	Psort location Cytoplasmic, score
CU648_00455	COG3397	chitin binding
CU648_00470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CU648_00475	COG1115	amino acid carrier protein
CU648_00480	COG1012	belongs to the aldehyde dehydrogenase family
CU648_00485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CU648_00495	COG3938	Belongs to the proline racemase family
CU648_00500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_00540	COG0586	Pfam SNARE associated Golgi protein
CU648_00555	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CU648_00560	COG0519	Catalyzes the synthesis of GMP from XMP
CU648_00565	COG4166	transmembrane transport
CU648_00575	COG4948	Mandelate Racemase Muconate Lactonizing
CU648_00620	COG2936	dipeptidyl-peptidase activity
CU648_00625	COG5002	protein histidine kinase activity
CU648_00630	COG0745	RESPONSE REGULATOR receiver
CU648_00660	COG1164	Oligoendopeptidase f
CU648_00665	COG0531	amino acid
CU648_00670	COG1522	sequence-specific DNA binding
CU648_00675	COG1307	EDD domain protein, DegV family
CU648_00715	COG2814	Major facilitator Superfamily
CU648_00725	COG1664	Polymer-forming cytoskeletal
CU648_00730	COG0789	Transcriptional regulator
CU648_00735	COG4533	DNA binding
CU648_00740	COG0477	Major facilitator Superfamily
CU648_00740	COG2814	Major facilitator Superfamily
CU648_00760	COG2261	transglycosylase associated protein
CU648_00775	COG2226	methyltransferase
CU648_00815	COG0436	Aminotransferase
CU648_00820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CU648_00825	COG5146	pantothenate kinase activity
CU648_00830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CU648_00850	COG1131	(ABC) transporter
CU648_00910	COG0628	permease
CU648_00925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_00930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_00935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU648_00980	COG2746	aminoglycoside 3-N-acetyltransferase activity
CU648_01010	COG0697	spore germination
CU648_01015	COG2318	DinB family
CU648_01035	COG4912	Dna alkylation repair
CU648_01050	COG0726	polysaccharide deacetylase
CU648_01060	COG0861	Integral membrane protein TerC family
CU648_01065	COG1368	sulfuric ester hydrolase activity
CU648_01075	COG0488	(ABC) transporter
CU648_01085	COG1033	growth of symbiont in host cell
CU648_01085	COG2409	Drug exporters of the RND superfamily
CU648_01090	COG1309	transcriptional regulator
CU648_01105	COG0287	Prephenate dehydrogenase
CU648_01110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CU648_01125	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CU648_01125	COG1605	Chorismate mutase
CU648_01165	COG3584	3D domain protein
CU648_01165	COG1388	LysM domain
CU648_01180	COG1595	DNA-templated transcription, initiation
CU648_01205	COG1879	ABC-type sugar transport system periplasmic component
CU648_01215	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU648_01225	COG2390	Transcriptional regulator
CU648_01230	COG1070	Carbohydrate kinase
CU648_01265	COG2329	Antibiotic biosynthesis monooxygenase
CU648_01285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_01295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CU648_01305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_01310	COG4187	Peptidase family M20/M25/M40
CU648_01315	COG1414	Transcriptional regulator
CU648_01325	COG0833	amino acid
CU648_01345	COG1690	Belongs to the RtcB family
CU648_01350	COG3239	Fatty acid desaturase
CU648_01355	COG1785	Belongs to the alkaline phosphatase family
CU648_01365	COG3655	Transcriptional regulator
CU648_01380	COG4377	Putative membrane peptidase family (DUF2324)
CU648_01390	COG3279	Response regulator of the LytR AlgR family
CU648_01410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_01415	COG0346	lactoylglutathione lyase activity
CU648_01440	COG0714	Associated with various cellular activities
CU648_01465	COG0463	Glycosyl transferase, family 2
CU648_01485	COG0463	Glycosyl transferase, family 2
CU648_01495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU648_01500	COG0753	catalase activity
CU648_01510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CU648_01535	COG0714	Associated with various cellular activities
CU648_01545	COG0778	Nitroreductase
CU648_01550	COG1846	Transcriptional regulator
CU648_01590	COG1725	Transcriptional regulator
CU648_01610	COG1136	(ABC) transporter
CU648_01635	COG2207	Transcriptional regulator
CU648_01640	COG0456	acetyltransferase
CU648_01660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_01710	COG0730	response to heat
CU648_01720	COG0833	amino acid
CU648_01730	COG4335	DNA alkylation repair
CU648_01795	COG1984	allophanate hydrolase subunit 2
CU648_01800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CU648_01805	COG1414	Transcriptional regulator
CU648_01830	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_01840	COG0640	Transcriptional regulator
CU648_01850	COG1960	acyl-CoA dehydrogenase activity
CU648_01895	COG0574	Belongs to the PEP-utilizing enzyme family
CU648_01895	COG3848	Pyruvate phosphate dikinase
CU648_01905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_01920	COG5577	PFAM Coat F domain
CU648_01930	COG3403	YqcI/YcgG family
CU648_01935	COG1280	lysine exporter protein (LysE YggA)
CU648_01940	COG1113	amino acid transport
CU648_01975	COG1063	alcohol dehydrogenase
CU648_02005	COG4974	Belongs to the 'phage' integrase family
CU648_02020	COG1335	isochorismatase
CU648_02025	COG0431	NADPH-dependent FMN reductase
CU648_02070	COG0210	DNA helicase
CU648_02075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CU648_02085	COG0737	Belongs to the 5'-nucleotidase family
CU648_02090	COG0753	catalase activity
CU648_02095	COG0598	Magnesium transport protein CorA
CU648_02140	COG0415	Belongs to the DNA photolyase family
CU648_02145	COG0288	reversible hydration of carbon dioxide
CU648_02155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CU648_02160	COG5609	conserved protein (DUF2294)
CU648_02175	COG0714	Associated with various cellular activities
CU648_02185	COG1575	Belongs to the MenA family. Type 1 subfamily
CU648_02190	COG2267	carboxylic ester hydrolase activity
CU648_02200	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU648_02205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU648_02210	COG1121	(ABC) transporter
CU648_02240	COG0798	PFAM Bile acid sodium symporter
CU648_02245	COG0346	lactoylglutathione lyase activity
CU648_02250	COG0640	Transcriptional regulator
CU648_02265	COG0443	Heat shock 70 kDa protein
CU648_02275	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_02280	COG1522	sequence-specific DNA binding
CU648_02295	COG0346	lactoylglutathione lyase activity
CU648_02340	COG2814	Major facilitator Superfamily
CU648_02370	COG0745	RESPONSE REGULATOR receiver
CU648_02375	COG3850	Histidine kinase
CU648_02375	COG5002	protein histidine kinase activity
CU648_02410	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CU648_02435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_02440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU648_02450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_02465	COG2309	aminopeptidase activity
CU648_02480	COG0789	Transcriptional regulator
CU648_02485	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CU648_02505	COG0577	efflux transmembrane transporter activity
CU648_02520	COG3850	Histidine kinase
CU648_02520	COG5002	protein histidine kinase activity
CU648_02530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_02550	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU648_02565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CU648_02585	COG1595	DNA-templated transcription, initiation
CU648_02600	COG0662	Cupin 2, conserved barrel domain protein
CU648_02610	COG2207	Transcriptional regulator
CU648_02610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_02640	COG3409	Peptidoglycan-binding domain 1 protein
CU648_02640	COG5632	N-Acetylmuramoyl-L-alanine amidase
CU648_02655	COG2814	Major facilitator Superfamily
CU648_02695	COG0477	Major facilitator Superfamily
CU648_02705	COG1846	Transcriptional regulator
CU648_02710	COG2814	Major facilitator Superfamily
CU648_02725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CU648_02730	COG1131	(ABC) transporter
CU648_02750	COG2076	Multidrug Resistance protein
CU648_02755	COG1309	transcriptional regulator
CU648_02765	COG2031	fatty acid transporter
CU648_02805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CU648_02820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CU648_02825	COG1288	antiporter activity
CU648_02840	COG2814	Major facilitator Superfamily
CU648_02845	COG1309	transcriptional regulator
CU648_02850	COG0789	Transcriptional regulator
CU648_02875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CU648_02900	COG1733	regulation of RNA biosynthetic process
CU648_02905	COG0778	Nitroreductase
CU648_02930	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_02940	COG1131	(ABC) transporter
CU648_02965	COG1011	Hydrolase
CU648_02995	COG0346	lactoylglutathione lyase activity
CU648_03000	COG1940	carbohydrate kinase activity
CU648_03005	COG0738	Major facilitator superfamily
CU648_03010	COG0110	maltose O-acetyltransferase activity
CU648_03015	COG0180	Tryptophanyl-tRNA synthetase
CU648_03025	COG0628	permease
CU648_03045	COG2226	methyltransferase
CU648_03055	COG0477	Major facilitator Superfamily
CU648_03085	COG1253	flavin adenine dinucleotide binding
CU648_03090	COG0789	Transcriptional regulator
CU648_03095	COG0697	spore germination
CU648_03100	COG1357	PFAM Pentapeptide repeats (8 copies)
CU648_03105	COG3813	Protein conserved in bacteria
CU648_03115	COG2706	6-phosphogluconolactonase activity
CU648_03120	COG1070	Carbohydrate kinase
CU648_03130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU648_03135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CU648_03145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CU648_03155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_03175	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_03195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_03195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_03205	COG1733	regulation of RNA biosynthetic process
CU648_03240	COG0814	amino acid
CU648_03270	COG1393	Belongs to the ArsC family
CU648_03280	COG2188	Transcriptional regulator
CU648_03285	COG0673	inositol 2-dehydrogenase activity
CU648_03290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CU648_03295	COG1733	regulation of RNA biosynthetic process
CU648_03300	COG1733	regulation of RNA biosynthetic process
CU648_03320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_03340	COG0384	phenazine biosynthesis protein PhzF
CU648_03355	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_03360	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU648_03365	COG1733	regulation of RNA biosynthetic process
CU648_03375	COG0726	polysaccharide deacetylase
CU648_03385	COG1191	sigma factor activity
CU648_03405	COG1309	transcriptional regulator
CU648_03435	COG3152	Membrane
CU648_03465	COG1151	hydroxylamine reductase activity
CU648_03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_03485	COG3409	Peptidoglycan-binding domain 1 protein
CU648_03485	COG3757	hydrolase, family 25
CU648_03520	COG2072	flavoprotein involved in K transport
CU648_03560	COG1113	amino acid transport
CU648_03580	COG2814	Major facilitator Superfamily
CU648_03615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU648_03620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU648_03635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_03640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_03645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_03650	COG3739	integral membrane protein
CU648_03655	COG0384	phenazine biosynthesis protein PhzF
CU648_03675	COG0583	DNA-binding transcription factor activity
CU648_03695	COG1193	negative regulation of DNA recombination
CU648_03710	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CU648_03715	COG1164	Oligoendopeptidase f
CU648_03720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_03750	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_03775	COG0640	Transcriptional regulator
CU648_03780	COG0604	alcohol dehydrogenase
CU648_03800	COG0457	Tetratricopeptide repeat
CU648_03810	COG0385	Bile acid
CU648_03815	COG0277	FAD linked oxidase domain protein
CU648_03855	COG1216	Glycosyl transferase, family 2
CU648_03860	COG1024	Enoyl-CoA hydratase
CU648_03870	COG1285	pathogenesis
CU648_03885	COG2514	catechol 2,3-dioxygenase activity
CU648_03890	COG2720	vancomycin resistance protein
CU648_03920	COG1278	Cold shock
CU648_03930	COG0716	FMN binding
CU648_03960	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_03970	COG0165	Argininosuccinate lyase
CU648_03985	COG4145	pantothenate transmembrane transporter activity
CU648_03995	COG1012	belongs to the aldehyde dehydrogenase family
CU648_04000	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_04015	COG1657	PFAM Prenyltransferase squalene oxidase
CU648_04020	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CU648_04025	COG2962	Rard protein
CU648_04030	COG3326	Membrane
CU648_04045	COG0489	protein tyrosine kinase activity
CU648_04055	COG0314	molybdopterin synthase activity
CU648_04060	COG0303	'Molybdopterin
CU648_04065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_04070	COG2116	formate transmembrane transporter activity
CU648_04085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU648_04090	COG5609	conserved protein (DUF2294)
CU648_04095	COG2427	Protein of unknown function (DUF1641)
CU648_04100	COG3383	formate dehydrogenase (NAD+) activity
CU648_04115	COG0697	spore germination
CU648_04155	COG2226	methyltransferase
CU648_04160	COG4166	transmembrane transport
CU648_04165	COG4166	transmembrane transport
CU648_04170	COG4166	transmembrane transport
CU648_04175	COG1301	dicarboxylic acid transport
CU648_04180	COG1316	TRANSCRIPTIONal
CU648_04190	COG1595	DNA-templated transcription, initiation
CU648_04215	COG1131	(ABC) transporter
CU648_04240	COG0673	inositol 2-dehydrogenase activity
CU648_04245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU648_04250	COG0187	DNA topoisomerase II activity
CU648_04260	COG1832	CoA-binding protein
CU648_04265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU648_04270	COG0745	RESPONSE REGULATOR receiver
CU648_04290	COG4841	protein insertion into membrane
CU648_04295	COG0824	Thioesterase
CU648_04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_04345	COG1132	(ABC) transporter
CU648_04350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CU648_04360	COG0726	polysaccharide deacetylase
CU648_04390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CU648_04405	COG0183	Belongs to the thiolase family
CU648_04410	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_04415	COG1268	BioY protein
CU648_04420	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_04475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_04485	COG5002	protein histidine kinase activity
CU648_04490	COG0400	carboxylic ester hydrolase activity
CU648_04495	COG0346	lactoylglutathione lyase activity
CU648_04500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_04505	COG0069	glutamate synthase activity
CU648_04510	COG1902	pentaerythritol trinitrate reductase activity
CU648_04515	COG1329	Transcriptional regulator
CU648_04520	COG0010	Belongs to the arginase family
CU648_04545	COG2226	methyltransferase
CU648_04590	COG4846	Membrane protein involved in cytochrome C biogenesis
CU648_04595	COG0785	Cytochrome C biogenesis protein
CU648_04620	COG1131	(ABC) transporter
CU648_04630	COG0583	DNA-binding transcription factor activity
CU648_04640	COG1346	cytolysis
CU648_04655	COG0730	response to heat
CU648_04670	COG3409	Peptidoglycan-binding domain 1 protein
CU648_04670	COG5632	N-Acetylmuramoyl-L-alanine amidase
CU648_04685	COG1132	(ABC) transporter
CU648_04690	COG1132	(ABC) transporter
CU648_04715	COG3639	organic phosphonate transmembrane transporter activity
CU648_04730	COG0737	Belongs to the 5'-nucleotidase family
CU648_04740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CU648_04760	COG1695	Transcriptional regulator
CU648_04775	COG5444	nuclease activity
CU648_04790	COG0174	glutamine synthetase
CU648_04795	COG0789	Transcriptional regulator
CU648_04800	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CU648_04805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU648_04810	COG2860	membrane
CU648_04815	COG0464	growth
CU648_04845	COG1388	LysM domain
CU648_04845	COG3584	3D domain protein
CU648_04855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU648_04855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU648_04855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CU648_04860	COG1105	Belongs to the carbohydrate kinase PfkB family
CU648_04865	COG1349	DNA-binding transcription factor activity
CU648_04870	COG1979	alcohol dehydrogenase
CU648_04875	COG2322	membrane
CU648_04890	COG1113	amino acid transport
CU648_04910	COG1408	metallophosphoesterase
CU648_04915	COG2116	formate transmembrane transporter activity
CU648_04930	COG2217	Heavy metal translocating P-type atpase
CU648_04935	COG2608	mercury ion transmembrane transporter activity
CU648_04940	COG1937	Protein conserved in bacteria
CU648_04950	COG2819	hydrolase of the alpha beta superfamily
CU648_04955	COG1120	ATPase activity
CU648_04960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_04965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_04970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_04975	COG0708	Exodeoxyribonuclease III
CU648_04980	COG2169	Transcriptional regulator
CU648_04985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU648_04990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CU648_05000	COG2364	Membrane
CU648_05015	COG2267	carboxylic ester hydrolase activity
CU648_05020	COG0346	lactoylglutathione lyase activity
CU648_05025	COG3300	MHYT domain
CU648_05025	COG5001	Diguanylate cyclase
CU648_05045	COG1346	cytolysis
CU648_05050	COG1380	Effector of murein hydrolase LrgA
CU648_05055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_05060	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_05060	COG0596	Alpha beta hydrolase
CU648_05065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU648_05085	COG1404	Belongs to the peptidase S8 family
CU648_05090	COG3773	Cell wall hydrolase
CU648_05105	COG1368	sulfuric ester hydrolase activity
CU648_05110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CU648_05160	COG4550	Control of competence regulator ComK, YlbF/YmcA
CU648_05170	COG1013	pyruvate-flavodoxin oxidoreductase activity
CU648_05175	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CU648_05175	COG0674	pyruvate-flavodoxin oxidoreductase activity
CU648_05185	COG2359	stage V sporulation protein S
CU648_05190	COG1692	metallophosphoesterase
CU648_05215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CU648_05220	COG1426	Protein conserved in bacteria
CU648_05235	COG0300	oxidoreductase activity
CU648_05240	COG0612	Peptidase, M16
CU648_05245	COG0612	Peptidase, M16
CU648_05270	COG2188	Transcriptional regulator
CU648_05275	COG1674	ftsk spoiiie
CU648_05285	COG0740	serine-type endopeptidase activity
CU648_05290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_05305	COG0527	aspartate kinase activity
CU648_05310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CU648_05315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU648_05320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CU648_05330	COG1873	PFAM PRC-barrel domain
CU648_05335	COG0612	Peptidase, M16
CU648_05340	COG0726	polysaccharide deacetylase
CU648_05355	COG0196	riboflavin kinase activity
CU648_05360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CU648_05370	COG1550	Protein conserved in bacteria
CU648_05380	COG1358	cellular component organization or biogenesis
CU648_05385	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CU648_05390	COG0195	Participates in both transcription termination and antitermination
CU648_05415	COG0750	zinc metalloprotease
CU648_05420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CU648_05425	COG4589	Belongs to the CDS family
CU648_05440	COG0528	UMP kinase activity
CU648_05470	COG4974	Belongs to the 'phage' integrase family
CU648_05480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CU648_05485	COG0758	DNA mediated transformation
CU648_05490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CU648_05530	COG1837	Belongs to the UPF0109 family
CU648_05540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CU648_05550	COG0552	protein localization to endoplasmic reticulum
CU648_05555	COG1196	nuclear chromosome segregation
CU648_05570	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_05575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CU648_05590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CU648_05595	COG1461	Dihydroxyacetone kinase
CU648_05600	COG1302	Protein conserved in bacteria
CU648_05615	COG1564	THIamine pyrophosphokinase
CU648_05620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CU648_05625	COG1162	GTPase activity
CU648_05630	COG0515	serine threonine protein kinase
CU648_05630	COG2815	serine threonine protein kinase
CU648_05635	COG0631	protein serine/threonine phosphatase activity
CU648_05645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CU648_05645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CU648_05655	COG0242	peptide deformylase activity
CU648_05660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CU648_05665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CU648_05675	COG0194	GDP metabolic process
CU648_05685	COG1561	YicC-like family, N-terminal region
CU648_05690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CU648_05700	COG0006	proline dipeptidase activity
CU648_05720	COG3069	C4-dicarboxylate transmembrane transporter activity
CU648_05760	COG0505	Belongs to the CarA family
CU648_05785	COG0564	pseudouridine synthase activity
CU648_05805	COG3599	regulation of cell shape
CU648_05810	COG2302	S4 RNA-binding domain
CU648_05815	COG0762	integral membrane protein
CU648_05825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CU648_05835	COG1873	PFAM PRC-barrel domain
CU648_05840	COG1191	sigma factor activity
CU648_05845	COG1191	sigma factor activity
CU648_05855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CU648_05860	COG0849	cell division
CU648_05865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CU648_05875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU648_05880	COG0772	Belongs to the SEDS family
CU648_05895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CU648_05900	COG0768	penicillin binding
CU648_05910	COG4839	cell division protein FtsL
CU648_05925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CU648_05945	COG1399	metal-binding, possibly nucleic acid-binding protein
CU648_05955	COG3480	Lon protease (S16) C-terminal proteolytic domain
CU648_05960	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU648_05965	COG3314	Sporulation integral membrane protein YlbJ
CU648_05975	COG0742	ribosomal rna small subunit methyltransferase
CU648_05990	COG3679	Belongs to the UPF0342 family
CU648_05995	COG0406	alpha-ribazole phosphatase activity
CU648_06010	COG2340	Cysteine-rich secretory protein family
CU648_06025	COG3344	reverse transcriptase
CU648_06035	COG3336	cytochrome c oxidase
CU648_06070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CU648_06080	COG0772	Belongs to the SEDS family
CU648_06090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CU648_06095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CU648_06105	COG4896	Protein conserved in bacteria
CU648_06130	COG0483	inositol monophosphate 1-phosphatase activity
CU648_06150	COG1982	Orn Lys Arg decarboxylase major
CU648_06200	COG0022	dehydrogenase e1 component
CU648_06205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU648_06215	COG0242	peptide deformylase activity
CU648_06220	COG0561	phosphatase activity
CU648_06235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_06240	COG0569	domain protein
CU648_06260	COG0583	DNA-binding transcription factor activity
CU648_06265	COG0517	IMP dehydrogenase activity
CU648_06275	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CU648_06290	COG4703	Protein of unknown function (DUF1797)
CU648_06305	COG2200	EAL domain
CU648_06310	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_06315	COG1408	metallophosphoesterase
CU648_06330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CU648_06370	COG2814	Major facilitator Superfamily
CU648_06395	COG3209	COG3209 Rhs family protein
CU648_06410	COG2205	protein histidine kinase activity
CU648_06420	COG0436	Aminotransferase
CU648_06425	COG1609	Transcriptional regulator
CU648_06430	COG3833	ABC-type maltose transport systems, permease component
CU648_06435	COG1175	transmembrane transport
CU648_06440	COG2182	Extracellular solute-binding protein
CU648_06450	COG0366	Alpha amylase catalytic
CU648_06455	COG3842	ATPase activity
CU648_06495	COG0183	Belongs to the thiolase family
CU648_06535	COG1695	Transcriptional regulator
CU648_06540	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_06560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CU648_06565	COG0436	Aminotransferase
CU648_06600	COG2084	Dehydrogenase
CU648_06610	COG3706	GGDEF domain
CU648_06615	COG0778	Nitroreductase
CU648_06640	COG1263	PTS System
CU648_06640	COG2190	(PTS) system
CU648_06640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_06645	COG3711	transcriptional antiterminator
CU648_06665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CU648_06695	COG1547	Domain of unknown function (DUF309)
CU648_06700	COG0456	acetyltransferase
CU648_06710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CU648_06715	COG4086	secreted protein
CU648_06720	COG0561	phosphatase activity
CU648_06725	COG0697	spore germination
CU648_06740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_06765	COG0733	neurotransmitter:sodium symporter activity
CU648_06785	COG1686	Belongs to the peptidase S11 family
CU648_06795	COG1725	Transcriptional regulator
CU648_06800	COG1131	(ABC) transporter
CU648_06820	COG1846	Transcriptional regulator
CU648_06835	COG0598	Magnesium transport protein CorA
CU648_06860	COG4974	Belongs to the 'phage' integrase family
CU648_06870	COG0735	belongs to the Fur family
CU648_06875	COG1300	Membrane
CU648_06895	COG0667	Aldo Keto reductase
CU648_06900	COG0656	L-ascorbic acid biosynthetic process
CU648_06905	COG0456	acetyltransferase
CU648_06905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU648_06915	COG0737	Belongs to the 5'-nucleotidase family
CU648_06915	COG1525	nuclease
CU648_06915	COG4085	toxin activity
CU648_06925	COG0596	Alpha beta hydrolase
CU648_06930	COG2056	Na+-H+ antiporter family
CU648_06935	COG1609	Transcriptional regulator
CU648_06940	COG0456	acetyltransferase
CU648_06945	COG1073	alpha beta
CU648_06960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_06960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CU648_06965	COG0307	riboflavin synthase, alpha
CU648_06985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CU648_06990	COG4106	trans-aconitate 2-methyltransferase activity
CU648_06995	COG2267	carboxylic ester hydrolase activity
CU648_07010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU648_07030	COG0737	Belongs to the 5'-nucleotidase family
CU648_07040	COG1522	sequence-specific DNA binding
CU648_07060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CU648_07070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CU648_07085	COG0300	oxidoreductase activity
CU648_07090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_07095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_07100	COG1760	l-serine dehydratase
CU648_07105	COG1760	l-serine dehydratase
CU648_07130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CU648_07140	COG2195	Cleaves the N-terminal amino acid of tripeptides
CU648_07145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_07160	COG1376	ErfK ybiS ycfS ynhG family protein
CU648_07165	COG4129	membrane
CU648_07170	COG1126	abc transporter atp-binding protein
CU648_07175	COG0765	amino acid transport
CU648_07180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_07200	COG2816	NAD+ diphosphatase activity
CU648_07205	COG0772	Belongs to the SEDS family
CU648_07215	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_07220	COG0022	dehydrogenase e1 component
CU648_07225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CU648_07230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CU648_07240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU648_07245	COG0280	phosphate acetyltransferase
CU648_07255	COG3290	protein histidine kinase activity
CU648_07255	COG3829	transcription factor binding
CU648_07265	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_07270	COG3093	addiction module antidote protein HigA
CU648_07280	COG0745	RESPONSE REGULATOR receiver
CU648_07290	COG0750	zinc metalloprotease
CU648_07295	COG0497	DNA recombination
CU648_07305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CU648_07315	COG0142	geranyltranstransferase activity
CU648_07340	COG1302	Protein conserved in bacteria
CU648_07345	COG0439	Biotin carboxylase
CU648_07350	COG0511	ligase activity, forming carbon-carbon bonds
CU648_07395	COG3854	ATPases associated with a variety of cellular activities
CU648_07420	COG0006	proline dipeptidase activity
CU648_07435	COG3872	metal-dependent enzyme
CU648_07445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CU648_07465	COG0095	Lipoate-protein ligase
CU648_07470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_07475	COG1609	Transcriptional regulator
CU648_07485	COG2076	Multidrug Resistance protein
CU648_07490	COG2076	Multidrug Resistance protein
CU648_07530	COG1131	(ABC) transporter
CU648_07535	COG1725	Transcriptional regulator
CU648_07570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU648_07615	COG2169	Transcriptional regulator
CU648_07620	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CU648_07650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU648_07655	COG2169	Transcriptional regulator
CU648_07680	COG2264	protein methyltransferase activity
CU648_07720	COG4970	Tfp pilus assembly protein FimT
CU648_07730	COG1459	type II secretion system
CU648_07735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CU648_07785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CU648_07790	COG0646	methionine synthase
CU648_07790	COG1410	methionine synthase
CU648_07795	COG0646	methionine synthase
CU648_07795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CU648_07800	COG0626	cystathionine gamma-synthase activity
CU648_07805	COG0626	cystathionine gamma-synthase activity
CU648_07825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_07835	COG1940	carbohydrate kinase activity
CU648_07840	COG4483	Protein conserved in bacteria
CU648_07845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CU648_07855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CU648_07860	COG0704	Plays a role in the regulation of phosphate uptake
CU648_07865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CU648_07870	COG0581	inorganic phosphate transmembrane transporter activity
CU648_07875	COG0573	inorganic phosphate transmembrane transporter activity
CU648_07880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU648_07890	COG0477	Major facilitator Superfamily
CU648_07895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU648_07920	COG0735	belongs to the Fur family
CU648_07925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CU648_07930	COG1121	(ABC) transporter
CU648_07935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_07965	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CU648_07970	COG2384	SAM-dependent methyltransferase
CU648_07975	COG2010	Cytochrome c
CU648_07980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CU648_07985	COG0358	DNA primase activity
CU648_08005	COG0517	IMP dehydrogenase activity
CU648_08020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CU648_08025	COG0295	cytidine deaminase activity
CU648_08030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CU648_08040	COG1480	7TM receptor with intracellular HD hydrolase
CU648_08045	COG1702	phosphate starvation-inducible protein PhoH
CU648_08065	COG1610	YqeY-like protein
CU648_08075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CU648_08080	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CU648_08100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CU648_08110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CU648_08115	COG1733	regulation of RNA biosynthetic process
CU648_08140	COG1466	dna polymerase III delta subunit
CU648_08150	COG0658	competence protein
CU648_08150	COG2333	competence protein COMEC
CU648_08155	COG2131	deaminase
CU648_08160	COG1555	photosystem II stabilization
CU648_08160	COG1596	polysaccharide export
CU648_08165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_08170	COG2226	methyltransferase
CU648_08175	COG0799	negative regulation of ribosome biogenesis
CU648_08180	COG1713	HD superfamily hydrolase involved in NAD metabolism
CU648_08190	COG1534	Rna-binding protein
CU648_08200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CU648_08205	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CU648_08220	COG1191	sigma factor activity
CU648_08230	COG1595	DNA-templated transcription, initiation
CU648_08240	COG0778	Nitroreductase
CU648_08245	COG2357	RelA SpoT domain protein
CU648_08255	COG1785	Belongs to the alkaline phosphatase family
CU648_08265	COG2267	carboxylic ester hydrolase activity
CU648_08300	COG1404	Belongs to the peptidase S8 family
CU648_08305	COG3186	Phenylalanine-4-hydroxylase
CU648_08315	COG2514	catechol 2,3-dioxygenase activity
CU648_08320	COG2259	Doxx family
CU648_08360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_08370	COG1012	belongs to the aldehyde dehydrogenase family
CU648_08370	COG1454	alcohol dehydrogenase
CU648_08375	COG0626	cystathionine gamma-synthase activity
CU648_08380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU648_08405	COG0768	penicillin binding
CU648_08435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CU648_08465	COG0628	permease
CU648_08485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CU648_08500	COG1104	cysteine desulfurase activity
CU648_08505	COG1959	2 iron, 2 sulfur cluster binding
CU648_08510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CU648_08525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CU648_08535	COG0124	histidyl-tRNA synthetase
CU648_08555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU648_08565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CU648_08565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CU648_08570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CU648_08575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU648_08575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CU648_08585	COG2244	polysaccharide biosynthetic process
CU648_08590	COG2323	membrane
CU648_08600	COG1862	Preprotein translocase
CU648_08630	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CU648_08665	COG0157	Belongs to the NadC ModD family
CU648_08670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CU648_08675	COG1104	cysteine desulfurase activity
CU648_08680	COG1827	regulation of RNA biosynthetic process
CU648_08685	COG2258	MOSC domain
CU648_08690	COG0077	Prephenate dehydratase
CU648_08695	COG0577	efflux transmembrane transporter activity
CU648_08700	COG0577	efflux transmembrane transporter activity
CU648_08705	COG1136	(ABC) transporter
CU648_08710	COG5002	protein histidine kinase activity
CU648_08715	COG0745	RESPONSE REGULATOR receiver
CU648_08725	COG3290	protein histidine kinase activity
CU648_08735	COG2868	ribosomal protein
CU648_08745	COG1530	ribonuclease E activity
CU648_08750	COG1994	Peptidase M50
CU648_08755	COG0739	heme binding
CU648_08760	COG2894	cell division
CU648_08775	COG1792	Involved in formation and maintenance of cell shape
CU648_08780	COG1077	Cell shape determining protein MreB Mrl
CU648_08790	COG0477	Major facilitator Superfamily
CU648_08795	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU648_08835	COG0285	dihydrofolate synthase activity
CU648_08840	COG0525	valine-tRNA ligase activity
CU648_08850	COG1388	LysM domain
CU648_08860	COG0113	porphobilinogen synthase activity
CU648_08865	COG1587	Uroporphyrinogen-III synthase
CU648_08875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU648_08885	COG1846	Transcriptional regulator
CU648_08890	COG1764	response to oxidative stress
CU648_08905	COG1067	ATP-dependent peptidase activity
CU648_08905	COG0470	DNA polymerase III
CU648_08960	COG0622	Phosphoesterase
CU648_08975	COG5401	PFAM Sporulation and spore germination
CU648_08995	COG1309	transcriptional regulator
CU648_09010	COG2197	response regulator
CU648_09015	COG2233	PERMEase
CU648_09025	COG0402	S-adenosylhomocysteine deaminase activity
CU648_09030	COG0402	S-adenosylhomocysteine deaminase activity
CU648_09050	COG0444	Belongs to the ABC transporter superfamily
CU648_09055	COG4608	Belongs to the ABC transporter superfamily
CU648_09060	COG3275	phosphorelay sensor kinase activity
CU648_09065	COG3279	Response regulator of the LytR AlgR family
CU648_09075	COG1983	PspC domain protein
CU648_09080	COG1396	sequence-specific DNA binding
CU648_09085	COG0697	spore germination
CU648_09095	COG1959	2 iron, 2 sulfur cluster binding
CU648_09100	COG1668	transmembrane transport
CU648_09105	COG4152	abc transporter atp-binding protein
CU648_09110	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CU648_09115	COG1360	Flagellar Motor Protein
CU648_09120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CU648_09125	COG1876	peptidase activity
CU648_09130	COG0824	Thioesterase
CU648_09135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CU648_09140	COG1053	succinate dehydrogenase
CU648_09145	COG2009	succinate dehydrogenase
CU648_09150	COG1719	4-vinyl reductase, 4VR
CU648_09160	COG3118	belongs to the thioredoxin family
CU648_09165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CU648_09170	COG2086	electron transfer activity
CU648_09175	COG1024	Enoyl-CoA hydratase
CU648_09180	COG1309	transcriptional regulator
CU648_09185	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_09210	COG2318	DinB family
CU648_09235	COG1131	(ABC) transporter
CU648_09240	COG2205	protein histidine kinase activity
CU648_09245	COG0745	RESPONSE REGULATOR receiver
CU648_09255	COG4895	conserved protein (DUF2196)
CU648_09260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CU648_09275	COG4509	Sortase family
CU648_09280	COG1120	ATPase activity
CU648_09295	COG5386	Cell surface protein
CU648_09300	COG5386	Cell surface protein
CU648_09305	COG1114	Component of the transport system for branched-chain amino acids
CU648_09310	COG1187	pseudouridine synthase activity
CU648_09325	COG1796	DNA polymerase
CU648_09325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CU648_09330	COG1286	toxin biosynthetic process
CU648_09360	COG0017	Asparaginyl-tRNA synthetase
CU648_09375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU648_09385	COG1418	mRNA catabolic process
CU648_09415	COG2814	Major facilitator Superfamily
CU648_09420	COG1566	PFAM secretion protein HlyD family protein
CU648_09425	COG1309	transcriptional regulator
CU648_09430	COG1363	Peptidase, m42
CU648_09450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CU648_09455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU648_09465	COG1484	DNA-dependent DNA replication
CU648_09470	COG3611	Membrane attachment protein
CU648_09480	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CU648_09490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU648_09495	COG0237	dephospho-CoA kinase activity
CU648_09500	COG1971	Probably functions as a manganese efflux pump
CU648_09505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CU648_09510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU648_09510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU648_09515	COG5002	protein histidine kinase activity
CU648_09520	COG0745	RESPONSE REGULATOR receiver
CU648_09545	COG0538	isocitrate dehydrogenase activity
CU648_09550	COG0372	Belongs to the citrate synthase family
CU648_09565	COG0628	permease
CU648_09570	COG3030	protein affecting phage T7 exclusion by the F plasmid
CU648_09595	COG1725	Transcriptional regulator
CU648_09600	COG0281	malic enzyme
CU648_09605	COG0587	DNA-directed DNA polymerase activity
CU648_09620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CU648_09640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU648_09650	COG4109	DRTGG domain
CU648_09665	COG0006	proline dipeptidase activity
CU648_09705	COG0662	Cupin 2, conserved barrel domain protein
CU648_09715	COG1476	TRANSCRIPTIONal
CU648_09730	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_09735	COG0589	response to stress
CU648_09785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_09805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CU648_09810	COG0827	DNA restriction-modification system
CU648_09815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CU648_09820	COG3874	Sporulation protein YtfJ
CU648_09830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CU648_09835	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CU648_09845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU648_09860	COG1104	cysteine desulfurase activity
CU648_09870	COG0583	DNA-binding transcription factor activity
CU648_09875	COG0697	spore germination
CU648_09880	COG1309	transcriptional regulator
CU648_09885	COG1956	GAF domain-containing protein
CU648_09890	COG0626	cystathionine gamma-synthase activity
CU648_09940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CU648_09950	COG1595	DNA-templated transcription, initiation
CU648_09965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU648_09970	COG0454	-acetyltransferase
CU648_09975	COG0517	IMP dehydrogenase activity
CU648_09980	COG0123	including yeast histone deacetylase and acetoin utilization protein
CU648_09990	COG0745	RESPONSE REGULATOR receiver
CU648_09995	COG5002	protein histidine kinase activity
CU648_10005	COG0666	response to abiotic stimulus
CU648_10040	COG1609	Transcriptional regulator
CU648_10055	COG4851	CamS sex pheromone cAM373 precursor
CU648_10060	COG3118	belongs to the thioredoxin family
CU648_10070	COG2309	aminopeptidase activity
CU648_10090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_10095	COG1695	Transcriptional regulator
CU648_10115	COG1674	ftsk spoiiie
CU648_10125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_10135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_10140	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CU648_10145	COG1363	Peptidase, m42
CU648_10155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_10170	COG0510	thiamine kinase activity
CU648_10175	COG1523	belongs to the glycosyl hydrolase 13 family
CU648_10190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU648_10195	COG1349	DNA-binding transcription factor activity
CU648_10200	COG1187	pseudouridine synthase activity
CU648_10205	COG2244	polysaccharide biosynthetic process
CU648_10210	COG2081	HI0933 family
CU648_10215	COG2814	Major facilitator Superfamily
CU648_10225	COG3832	glyoxalase III activity
CU648_10250	COG1329	Transcriptional regulator
CU648_10275	COG0314	molybdopterin synthase activity
CU648_10290	COG1763	Mo-molybdopterin cofactor biosynthetic process
CU648_10295	COG0303	'Molybdopterin
CU648_10305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_10310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CU648_10330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_10340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CU648_10385	COG2814	Major facilitator Superfamily
CU648_10390	COG0475	glutathione-regulated potassium exporter activity
CU648_10395	COG0490	domain, Protein
CU648_10400	COG0582	viral genome integration into host DNA
CU648_10410	COG1136	(ABC) transporter
CU648_10435	COG1242	4 iron, 4 sulfur cluster binding
CU648_10440	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CU648_10455	COG1794	racemase activity, acting on amino acids and derivatives
CU648_10480	COG2267	carboxylic ester hydrolase activity
CU648_10485	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CU648_10490	COG0671	phosphoesterase, PA-phosphatase related
CU648_10495	COG0438	transferase activity, transferring glycosyl groups
CU648_10505	COG0521	Mo-molybdopterin cofactor biosynthetic process
CU648_10570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CU648_10575	COG5002	protein histidine kinase activity
CU648_10580	COG4191	Histidine kinase
CU648_10585	COG2267	carboxylic ester hydrolase activity
CU648_10590	COG1368	sulfuric ester hydrolase activity
CU648_10610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU648_10615	COG1116	anion transmembrane transporter activity
CU648_10620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_10635	COG0546	phosphoglycolate phosphatase activity
CU648_10645	COG0494	nUDIX hydrolase
CU648_10685	COG0288	reversible hydration of carbon dioxide
CU648_10690	COG1271	oxidase subunit
CU648_10695	COG1294	oxidase, subunit
CU648_10745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_10770	COG1842	Phage shock protein A
CU648_10825	COG5002	protein histidine kinase activity
CU648_10830	COG0745	RESPONSE REGULATOR receiver
CU648_10860	COG1597	lipid kinase activity
CU648_10875	COG0577	efflux transmembrane transporter activity
CU648_10880	COG1136	(ABC) transporter
CU648_10895	COG0586	Pfam SNARE associated Golgi protein
CU648_10915	COG0577	efflux transmembrane transporter activity
CU648_10920	COG1136	(ABC) transporter
CU648_10925	COG2207	Transcriptional regulator
CU648_10925	COG3708	Transcriptional regulator
CU648_10930	COG0745	RESPONSE REGULATOR receiver
CU648_10935	COG2205	protein histidine kinase activity
CU648_10940	COG0577	efflux transmembrane transporter activity
CU648_10945	COG0577	efflux transmembrane transporter activity
CU648_10950	COG1136	(ABC) transporter
CU648_10955	COG0577	efflux transmembrane transporter activity
CU648_10990	COG3964	amidohydrolase
CU648_11010	COG4948	Mandelate Racemase Muconate Lactonizing
CU648_11025	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CU648_11030	COG0596	Alpha beta hydrolase
CU648_11040	COG1169	isochorismate synthase
CU648_11045	COG1575	Belongs to the MenA family. Type 1 subfamily
CU648_11050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CU648_11055	COG1278	Cold shock
CU648_11075	COG0058	SHG alpha-glucan phosphorylase activity
CU648_11085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU648_11090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CU648_11105	COG1404	Belongs to the peptidase S8 family
CU648_11110	COG0039	L-malate dehydrogenase activity
CU648_11210	COG0544	peptidyl-prolyl cis-trans isomerase activity
CU648_11250	COG1285	pathogenesis
CU648_11255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CU648_11275	COG2155	Conserved Protein
CU648_11280	COG1098	S1 RNA binding domain
CU648_11285	COG0436	Aminotransferase
CU648_11290	COG1522	sequence-specific DNA binding
CU648_11295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CU648_11300	COG2267	carboxylic ester hydrolase activity
CU648_11310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CU648_11325	COG5018	Exonuclease
CU648_11330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU648_11350	COG0423	glycine-tRNA ligase activity
CU648_11355	COG2050	protein possibly involved in aromatic compounds catabolism
CU648_11365	COG1268	BioY protein
CU648_11370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CU648_11375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CU648_11390	COG3584	3D domain protein
CU648_11405	COG1252	NADH dehydrogenase
CU648_11420	COG3708	Transcriptional regulator
CU648_11435	COG1683	Conserved Protein
CU648_11455	COG0316	Belongs to the HesB IscA family
CU648_11470	COG1252	NADH dehydrogenase
CU648_11480	COG2274	protein secretion by the type I secretion system
CU648_11485	COG0390	transport system, permease component
CU648_11490	COG2824	Alkylphosphonate utilization operon protein PhnA
CU648_11530	COG4837	Protein of unknown function (DUF1462)
CU648_11535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CU648_11550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU648_11555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CU648_11565	COG2249	NAD(P)H dehydrogenase (quinone) activity
CU648_11575	COG0647	UMP catabolic process
CU648_11585	COG2445	Protein of unknown function DUF86
CU648_11590	COG1494	fructose-1,6-bisphosphatase
CU648_11610	COG4470	Protein conserved in bacteria
CU648_11620	COG0789	Transcriptional regulator
CU648_11625	COG4377	Putative membrane peptidase family (DUF2324)
CU648_11650	COG0739	heme binding
CU648_11660	COG3377	Domain of unknown function (DUF1805)
CU648_11665	COG0737	Belongs to the 5'-nucleotidase family
CU648_11680	COG0719	Fe-S assembly protein
CU648_11685	COG0822	iron-sulfur transferase activity
CU648_11690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CU648_11695	COG0719	Fe-S assembly protein
CU648_11700	COG0396	ATPase activity
CU648_11705	COG1464	Belongs to the NlpA lipoprotein family
CU648_11710	COG1464	Belongs to the NlpA lipoprotein family
CU648_11715	COG2011	ABC-type metal ion transport system permease component
CU648_11720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CU648_11730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_11735	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CU648_11745	COG1393	Belongs to the ArsC family
CU648_11800	COG0039	L-malate dehydrogenase activity
CU648_11830	COG1309	transcriptional regulator
CU648_11835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_11840	COG1960	acyl-CoA dehydrogenase activity
CU648_11850	COG0183	Belongs to the thiolase family
CU648_11855	COG1024	Enoyl-CoA hydratase
CU648_11855	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU648_11870	COG1686	Belongs to the peptidase S11 family
CU648_11885	COG0011	TIGRFAM Protein of
CU648_11890	COG0840	transmembrane signaling receptor activity
CU648_11905	COG2814	Major facilitator Superfamily
CU648_11910	COG0531	amino acid
CU648_11925	COG0706	membrane insertase activity
CU648_11935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_11980	COG0586	Pfam SNARE associated Golgi protein
CU648_11990	COG1376	ErfK ybiS ycfS ynhG family protein
CU648_11995	COG0745	RESPONSE REGULATOR receiver
CU648_12000	COG5002	protein histidine kinase activity
CU648_12030	COG0840	transmembrane signaling receptor activity
CU648_12035	COG2151	metal-sulfur cluster biosynthetic enzyme
CU648_12040	COG3227	Zinc metalloprotease (Elastase)
CU648_12045	COG1741	Belongs to the pirin family
CU648_12060	COG0475	glutathione-regulated potassium exporter activity
CU648_12065	COG0490	domain, Protein
CU648_12075	COG1115	amino acid carrier protein
CU648_12080	COG0783	Belongs to the Dps family
CU648_12100	COG1611	Belongs to the LOG family
CU648_12120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_12125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_12130	COG1115	amino acid carrier protein
CU648_12135	COG1115	amino acid carrier protein
CU648_12140	COG2910	NAD(P)H-binding
CU648_12165	COG0656	L-ascorbic acid biosynthetic process
CU648_12170	COG2814	Major facilitator Superfamily
CU648_12175	COG1733	regulation of RNA biosynthetic process
CU648_12185	COG1252	NADH dehydrogenase
CU648_12190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CU648_12205	COG3290	protein histidine kinase activity
CU648_12205	COG0840	transmembrane signaling receptor activity
CU648_12235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_12245	COG2814	Major facilitator Superfamily
CU648_12255	COG3223	Belongs to the PsiE family
CU648_12365	COG0557	exoribonuclease II activity
CU648_12370	COG1647	Serine aminopeptidase, S33
CU648_12375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CU648_12380	COG1346	cytolysis
CU648_12415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CU648_12430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CU648_12455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_12470	COG2323	membrane
CU648_12485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU648_12495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CU648_12505	COG1051	belongs to the nudix hydrolase family
CU648_12515	COG0492	ferredoxin-NADP+ reductase activity
CU648_12520	COG0457	Tetratricopeptide repeat
CU648_12525	COG0110	maltose O-acetyltransferase activity
CU648_12545	COG1950	PFAM Membrane protein of
CU648_12555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU648_12575	COG0789	Transcriptional regulator
CU648_12615	COG0583	DNA-binding transcription factor activity
CU648_12625	COG0655	NAD(P)H dehydrogenase (quinone) activity
CU648_12640	COG1132	(ABC) transporter
CU648_12650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU648_12655	COG3409	Peptidoglycan-binding domain 1 protein
CU648_12655	COG0793	Belongs to the peptidase S41A family
CU648_12660	COG2177	Part of the ABC transporter FtsEX involved in
CU648_12665	COG2884	Cell division ATP-binding protein ftsE
CU648_12690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CU648_12695	COG1278	Cold shock
CU648_12700	COG1040	competence protein
CU648_12705	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CU648_12710	COG1388	LysM domain
CU648_12710	COG0791	NLP P60 protein
CU648_12715	COG1733	regulation of RNA biosynthetic process
CU648_12725	COG1307	EDD domain protein, DegV family
CU648_12730	COG1739	Uncharacterized protein family UPF0029
CU648_12735	COG1316	TRANSCRIPTIONal
CU648_12740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CU648_12745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU648_12750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CU648_12760	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CU648_12760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CU648_12790	COG3394	polysaccharide catabolic process
CU648_12795	COG1486	melibiose metabolic process
CU648_12800	COG1447	Phosphotransferase system cellobiose-specific component IIA
CU648_12805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU648_12815	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CU648_12825	COG1447	Phosphotransferase system cellobiose-specific component IIA
CU648_12835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU648_12840	COG1301	dicarboxylic acid transport
CU648_12875	COG1511	domain protein
CU648_12880	COG0583	DNA-binding transcription factor activity
CU648_12885	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CU648_12900	COG1271	oxidase subunit
CU648_12905	COG1294	oxidase, subunit
CU648_12910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CU648_12945	COG1620	l-lactate permease
CU648_12955	COG2389	metal-binding protein
CU648_12970	COG1368	sulfuric ester hydrolase activity
CU648_12985	COG0791	NLP P60 protein
CU648_12985	COG1388	LysM domain
CU648_12990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_13000	COG1215	transferase activity, transferring glycosyl groups
CU648_13010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU648_13020	COG3584	3D domain protein
CU648_13020	COG1388	LysM domain
CU648_13045	COG4715	Zinc finger, swim domain protein
CU648_13050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU648_13080	COG1191	sigma factor activity
CU648_13095	COG0577	efflux transmembrane transporter activity
CU648_13100	COG1136	(ABC) transporter
CU648_13125	COG5002	protein histidine kinase activity
CU648_13130	COG0745	RESPONSE REGULATOR receiver
CU648_13135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU648_13155	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CU648_13165	COG1215	transferase activity, transferring glycosyl groups
CU648_13185	COG0438	transferase activity, transferring glycosyl groups
CU648_13190	COG1045	serine acetyltransferase
CU648_13195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CU648_13200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CU648_13205	COG1086	Polysaccharide biosynthesis protein
CU648_13210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CU648_13215	COG4464	protein tyrosine phosphatase activity
CU648_13220	COG0489	protein tyrosine kinase activity
CU648_13225	COG3944	biosynthesis protein
CU648_13230	COG0489	protein tyrosine kinase activity
CU648_13245	COG1609	Transcriptional regulator
CU648_13255	COG0739	heme binding
CU648_13270	COG3279	Response regulator of the LytR AlgR family
CU648_13275	COG2385	sporulation resulting in formation of a cellular spore
CU648_13280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CU648_13290	COG4836	Membrane
CU648_13295	COG1007	ATP synthesis coupled electron transport
CU648_13300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU648_13305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CU648_13315	COG0839	Belongs to the complex I subunit 6 family
CU648_13330	COG0649	NAD binding
CU648_13335	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU648_13345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CU648_13350	COG5001	Diguanylate cyclase
CU648_13350	COG3300	MHYT domain
CU648_13405	COG0356	it plays a direct role in the translocation of protons across the membrane
CU648_13440	COG0698	ribose 5-phosphate isomerase
CU648_13455	COG2190	(PTS) system
CU648_13460	COG2259	Doxx family
CU648_13465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CU648_13485	COG0009	L-threonylcarbamoyladenylate synthase
CU648_13500	COG2890	protein-(glutamine-N5) methyltransferase activity
CU648_13505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CU648_13520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CU648_13525	COG1494	fructose-1,6-bisphosphatase
CU648_13535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CU648_13550	COG4821	SIS domain
CU648_13570	COG1960	acyl-CoA dehydrogenase activity
CU648_13575	COG1960	acyl-CoA dehydrogenase activity
CU648_13580	COG1250	3-hydroxyacyl-CoA dehydrogenase
CU648_13585	COG0183	Belongs to the thiolase family
CU648_13590	COG2181	nitrate reductase activity
CU648_13590	COG0247	lactate metabolic process
CU648_13595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_13605	COG3300	MHYT domain
CU648_13605	COG5001	Diguanylate cyclase
CU648_13625	COG2197	response regulator
CU648_13630	COG4585	Histidine kinase
CU648_13635	COG0842	Transport permease protein
CU648_13640	COG1131	(ABC) transporter
CU648_13645	COG0024	Methionine aminopeptidase
CU648_13660	COG2234	aminopeptidase activity
CU648_13680	COG1595	DNA-templated transcription, initiation
CU648_13690	COG4506	Protein conserved in bacteria
CU648_13695	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU648_13710	COG0010	Belongs to the arginase family
CU648_13715	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CU648_13720	COG2814	Major facilitator Superfamily
CU648_13725	COG0789	Transcriptional regulator
CU648_13730	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_13735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_13745	COG1994	Peptidase M50
CU648_13755	COG1078	dGTPase activity
CU648_13760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_13765	COG1120	ATPase activity
CU648_13770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_13775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_13795	COG0095	Lipoate-protein ligase
CU648_13800	COG0280	phosphate acetyltransferase
CU648_13815	COG3773	Cell wall hydrolase
CU648_13825	COG2363	Small membrane protein
CU648_13835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CU648_13840	COG2233	PERMEase
CU648_13845	COG0561	phosphatase activity
CU648_13850	COG2814	Major facilitator Superfamily
CU648_13875	COG1476	TRANSCRIPTIONal
CU648_13880	COG3118	belongs to the thioredoxin family
CU648_13890	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CU648_13895	COG1131	(ABC) transporter
CU648_13900	COG2755	lipolytic protein G-D-S-L family
CU648_13905	COG1609	Transcriptional regulator
CU648_13915	COG0460	homoserine dehydrogenase
CU648_13935	COG1011	Hydrolase
CU648_13940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU648_13950	COG2197	response regulator
CU648_13955	COG2203	Gaf domain
CU648_13955	COG4585	Histidine kinase
CU648_13960	COG0351	phosphomethylpyrimidine kinase
CU648_13965	COG3706	GGDEF domain
CU648_13970	COG2879	small protein
CU648_13975	COG1966	Carbon starvation protein
CU648_13980	COG3279	Response regulator of the LytR AlgR family
CU648_13985	COG0477	Major facilitator Superfamily
CU648_14010	COG0840	transmembrane signaling receptor activity
CU648_14020	COG1607	acyl-coa hydrolase
CU648_14035	COG0488	(ABC) transporter
CU648_14055	COG0463	Glycosyl transferase, family 2
CU648_14060	COG1309	transcriptional regulator
CU648_14065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU648_14070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU648_14070	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU648_14075	COG0628	permease
CU648_14090	COG3279	Response regulator of the LytR AlgR family
CU648_14095	COG3275	phosphorelay sensor kinase activity
CU648_14100	COG2814	Major facilitator Superfamily
CU648_14105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU648_14110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CU648_14120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU648_14140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CU648_14145	COG1272	protein, Hemolysin III
CU648_14170	COG1164	Oligoendopeptidase f
CU648_14190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CU648_14195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CU648_14200	COG4853	Protein conserved in bacteria
CU648_14205	COG4863	YycH protein
CU648_14210	COG5002	protein histidine kinase activity
CU648_14215	COG0745	RESPONSE REGULATOR receiver
CU648_14245	COG0305	Participates in initiation and elongation during chromosome replication
CU648_14255	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CU648_14260	COG4241	membrane
CU648_14270	COG0629	single-stranded DNA binding
CU648_14280	COG0012	GTP binding
CU648_14285	COG4481	Protein conserved in bacteria
CU648_14290	COG0668	transmembrane transport
CU648_14300	COG1475	DNA binding
CU648_14305	COG1192	Involved in chromosome partitioning
CU648_14330	COG1847	R3H domain protein
CU648_14335	COG0706	membrane insertase activity
CU648_14355	COG0592	DNA-directed DNA polymerase activity
CU648_14360	COG2501	S4 domain
CU648_14370	COG0187	DNA topoisomerase II activity
CU648_14375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CU648_14410	COG0517	IMP dehydrogenase activity
CU648_14410	COG0516	GMP reductase activity
CU648_14415	COG1686	Belongs to the peptidase S11 family
CU648_14445	COG1428	Deoxynucleoside kinase
CU648_14450	COG1428	Deoxynucleoside kinase
CU648_14455	COG1335	isochorismatase
CU648_14465	COG0590	tRNA wobble adenosine to inosine editing
CU648_14475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CU648_14530	COG1982	Orn Lys Arg decarboxylase major
CU648_14540	COG0470	DNA polymerase III
CU648_14545	COG1774	PSP1 C-terminal conserved region
CU648_14555	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CU648_14565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CU648_14570	COG2002	toxin-antitoxin pair type II binding
CU648_14575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_14575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_14580	COG0084	hydrolase, TatD family'
CU648_14585	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CU648_14600	COG4466	Protein conserved in bacteria
CU648_14615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CU648_14625	COG0251	oxidation-reduction process
CU648_14640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CU648_14645	COG0193	aminoacyl-tRNA hydrolase activity
CU648_14655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CU648_14660	COG2002	toxin-antitoxin pair type II binding
CU648_14665	COG2244	polysaccharide biosynthetic process
CU648_14670	COG3956	TIGRFAM MazG family protein
CU648_14675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CU648_14695	COG1098	S1 RNA binding domain
CU648_14710	COG2208	phosphoserine phosphatase activity
CU648_14725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CU648_14740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU648_14745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CU648_14750	COG0512	Glutamine amidotransferase of anthranilate synthase
CU648_14755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_14760	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CU648_14765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CU648_14770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CU648_14775	COG1396	sequence-specific DNA binding
CU648_14780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU648_14870	COG3880	PFAM UvrB UvrC protein
CU648_14880	COG0542	response to heat
CU648_14885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CU648_14895	COG4956	integral membrane protein (PIN domain superfamily)
CU648_14915	COG1045	serine acetyltransferase
CU648_14930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CU648_14935	COG3688	RNA-binding protein containing a PIN domain
CU648_14945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CU648_14950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CU648_14955	COG0250	Participates in transcription elongation, termination and antitermination
CU648_14980	COG2813	Specifically methylates the guanine in position
CU648_14995	COG1358	cellular component organization or biogenesis
CU648_15100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CU648_15125	COG0201	protein transport
CU648_15135	COG0024	Methionine aminopeptidase
CU648_15145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CU648_15175	COG1122	ATPase activity
CU648_15180	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CU648_15185	COG0101	tRNA pseudouridine synthase activity
CU648_15205	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_15210	COG0489	protein tyrosine kinase activity
CU648_15220	COG2194	sulfuric ester hydrolase activity
CU648_15225	COG0726	polysaccharide deacetylase
CU648_15305	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CU648_15310	COG4856	YbbR-like protein
CU648_15360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CU648_15385	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_15390	COG2011	ABC-type metal ion transport system permease component
CU648_15400	COG1464	Belongs to the NlpA lipoprotein family
CU648_15415	COG0277	FAD linked oxidase domain protein
CU648_15420	COG2271	Major facilitator Superfamily
CU648_15430	COG2814	Major facilitator Superfamily
CU648_15445	COG0601	transmembrane transport
CU648_15450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_15455	COG0444	Belongs to the ABC transporter superfamily
CU648_15460	COG4608	Belongs to the ABC transporter superfamily
CU648_15465	COG4166	transmembrane transport
CU648_15475	COG2207	Transcriptional regulator
CU648_15485	COG1309	transcriptional regulator
CU648_15495	COG4166	transmembrane transport
CU648_15500	COG4166	transmembrane transport
CU648_15505	COG0656	L-ascorbic acid biosynthetic process
CU648_15510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CU648_15535	COG4149	molybdate abc transporter
CU648_15540	COG0725	ABC transporter, periplasmic molybdate-binding protein
CU648_15545	COG1910	domain protein
CU648_15565	COG0697	spore germination
CU648_15580	COG0204	Acyl-transferase
CU648_15595	COG1609	Transcriptional regulator
CU648_15605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_15630	COG5298	Protein conserved in bacteria
CU648_15655	COG0488	(ABC) transporter
CU648_15665	COG0747	negative chemotaxis
CU648_15670	COG0747	negative chemotaxis
CU648_15675	COG0601	transmembrane transport
CU648_15685	COG0444	Belongs to the ABC transporter superfamily
CU648_15690	COG4608	Belongs to the ABC transporter superfamily
CU648_15695	COG0561	phosphatase activity
CU648_15730	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CU648_15735	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU648_15750	COG0531	amino acid
CU648_15755	COG2814	Major facilitator Superfamily
CU648_15765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CU648_15775	COG4294	response to UV
CU648_15780	COG0705	Rhomboid family
CU648_15780	COG0457	Tetratricopeptide repeat
CU648_15790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CU648_15795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CU648_15800	COG0864	Transcriptional regulator
CU648_15805	COG2337	Toxic component of a toxin-antitoxin (TA) module
CU648_15810	COG2183	response to ionizing radiation
CU648_15905	COG0802	atpase or kinase
CU648_15910	COG1214	PFAM Peptidase M22, glycoprotease
CU648_15915	COG0456	acetyltransferase
CU648_15925	COG0488	(ABC) transporter
CU648_15940	COG1266	CAAX protease self-immunity
CU648_15955	COG1192	Involved in chromosome partitioning
CU648_15975	COG2252	PERMEase
CU648_15985	COG5002	protein histidine kinase activity
CU648_16010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU648_16050	COG2205	protein histidine kinase activity
CU648_16055	COG0745	RESPONSE REGULATOR receiver
CU648_16075	COG0697	spore germination
CU648_16105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CU648_16110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CU648_16115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CU648_16125	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CU648_16140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CU648_16150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CU648_16160	COG0151	Belongs to the GarS family
CU648_16190	COG0210	DNA helicase
CU648_16200	COG4851	CamS sex pheromone cAM373 precursor
CU648_16220	COG1335	isochorismatase
CU648_16230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CU648_16235	COG2011	ABC-type metal ion transport system permease component
CU648_16240	COG1464	Belongs to the NlpA lipoprotein family
CU648_16255	COG0003	Pfam Anion-transporting ATPase
CU648_16260	COG1846	Transcriptional regulator
CU648_16265	COG4682	membrane
CU648_16285	COG1597	lipid kinase activity
CU648_16290	COG0546	phosphoglycolate phosphatase activity
CU648_16295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CU648_16305	COG1012	belongs to the aldehyde dehydrogenase family
CU648_16310	COG2076	Multidrug Resistance protein
CU648_16315	COG2309	aminopeptidase activity
CU648_16330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_16335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CU648_16340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CU648_16345	COG5002	protein histidine kinase activity
CU648_16350	COG4807	Protein conserved in bacteria
CU648_16380	COG1473	amidohydrolase
CU648_16395	COG0450	alkyl hydroperoxide reductase
CU648_16400	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CU648_16410	COG0235	Class ii aldolase
CU648_16415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_16420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_16425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_16450	COG0166	Belongs to the GPI family
CU648_16490	COG5002	protein histidine kinase activity
CU648_16510	COG3541	Predicted nucleotidyltransferase
CU648_16515	COG2814	Major facilitator Superfamily
CU648_16520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_16520	COG0723	plastoquinol--plastocyanin reductase activity
CU648_16545	COG0765	amino acid transport
CU648_16550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_16565	COG0840	transmembrane signaling receptor activity
CU648_16570	COG0840	transmembrane signaling receptor activity
CU648_16575	COG0366	Alpha amylase catalytic
CU648_16580	COG2190	(PTS) system
CU648_16580	COG1263	PTS System
CU648_16580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_16610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CU648_16625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_16635	COG1116	anion transmembrane transporter activity
CU648_16645	COG0488	(ABC) transporter
CU648_16695	COG2270	Major facilitator Superfamily
CU648_16725	COG2310	stress, protein
CU648_16730	COG2310	stress, protein
CU648_16735	COG2310	stress, protein
CU648_16740	COG0861	Integral membrane protein TerC family
CU648_16750	COG3853	Toxic anion resistance protein (TelA)
CU648_16760	COG3328	transposase activity
CU648_16765	COG0456	acetyltransferase
CU648_16775	COG0456	acetyltransferase
CU648_16785	COG3328	transposase activity
CU648_16800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CU648_16810	COG1295	ribonuclease BN
CU648_16820	COG2217	Heavy metal translocating P-type atpase
CU648_16825	COG0697	spore germination
CU648_16835	COG0681	Belongs to the peptidase S26 family
CU648_16845	COG0586	Pfam SNARE associated Golgi protein
CU648_16860	COG3871	stress protein (general stress protein 26)
CU648_16865	COG0387	Pfam Sodium calcium exchanger
CU648_16875	COG0535	radical SAM domain protein
CU648_16895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CU648_16900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CU648_16905	COG0101	tRNA pseudouridine synthase activity
CU648_16915	COG3829	transcription factor binding
CU648_16925	COG0833	amino acid
CU648_16930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU648_16960	COG2066	Belongs to the glutaminase family
CU648_16970	COG1263	PTS System
CU648_16970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_16975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_16995	COG0463	Glycosyl transferase, family 2
CU648_17005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU648_17005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CU648_17025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CU648_17045	COG1228	amidohydrolase
CU648_17050	COG1090	epimerase
CU648_17080	COG1988	membrane-bound metal-dependent
CU648_17085	COG1194	a g-specific adenine glycosylase
CU648_17110	COG1132	(ABC) transporter
CU648_17115	COG4129	membrane
CU648_17120	COG0069	glutamate synthase activity
CU648_17120	COG0067	glutamate synthase
CU648_17120	COG0070	glutamate synthase
CU648_17130	COG4555	ABC transporter
CU648_17150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CU648_17155	COG0735	belongs to the Fur family
CU648_17260	COG4974	Belongs to the 'phage' integrase family
CU648_17280	COG4695	Portal protein
CU648_17380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CU648_17385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CU648_17395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CU648_17405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CU648_17420	COG2766	serine protein kinase
CU648_17450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_17455	COG1126	abc transporter atp-binding protein
CU648_17460	COG0765	amino acid transport
CU648_17465	COG0765	amino acid transport
CU648_17470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CU648_17480	COG1585	Membrane protein implicated in regulation of membrane protease activity
CU648_17485	COG2268	Band 7 protein
CU648_17495	COG3290	protein histidine kinase activity
CU648_17500	COG4565	transcriptional regulatory protein
CU648_17505	COG2851	Citrate transporter
CU648_17525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CU648_17530	COG3842	ATPase activity
CU648_17535	COG1175	transmembrane transport
CU648_17540	COG0395	ABC-type sugar transport system, permease component
CU648_17550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CU648_17555	COG0745	RESPONSE REGULATOR receiver
CU648_17560	COG5002	protein histidine kinase activity
CU648_17570	COG4990	cell redox homeostasis
CU648_17580	COG3290	protein histidine kinase activity
CU648_17585	COG4565	transcriptional regulatory protein
CU648_17590	COG3493	citrate carrier protein
CU648_17595	COG0281	malic enzyme
CU648_17610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_17620	COG5002	protein histidine kinase activity
CU648_17625	COG0745	RESPONSE REGULATOR receiver
CU648_17635	COG0454	-acetyltransferase
CU648_17635	COG0456	acetyltransferase
CU648_17640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CU648_17645	COG3383	formate dehydrogenase (NAD+) activity
CU648_17650	COG2427	Protein of unknown function (DUF1641)
CU648_17665	COG0531	amino acid
CU648_17675	COG0640	Transcriptional regulator
CU648_17680	COG2217	Heavy metal translocating P-type atpase
CU648_17685	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CU648_17695	COG3227	Zinc metalloprotease (Elastase)
CU648_17715	COG2720	vancomycin resistance protein
CU648_17720	COG1316	TRANSCRIPTIONal
CU648_17725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_17730	COG0346	lactoylglutathione lyase activity
CU648_17735	COG1253	flavin adenine dinucleotide binding
CU648_17740	COG1027	Aspartate ammonia-lyase
CU648_17745	COG1620	l-lactate permease
CU648_17760	COG3104	oligopeptide transport
CU648_17765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_17770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_17775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CU648_17790	COG0156	8-amino-7-oxononanoate synthase activity
CU648_17795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CU648_17805	COG4548	von Willebrand factor, type A
CU648_17810	COG0714	Associated with various cellular activities
CU648_17815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_17835	COG0531	amino acid
CU648_17840	COG2188	Transcriptional regulator
CU648_17845	COG1263	PTS System
CU648_17845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_17850	COG0366	Alpha amylase catalytic
CU648_17865	COG0697	spore germination
CU648_17875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CU648_17880	COG1115	amino acid carrier protein
CU648_17885	COG1126	abc transporter atp-binding protein
CU648_17890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_17895	COG0765	amino acid transport
CU648_17900	COG0765	amino acid transport
CU648_17905	COG0833	amino acid
CU648_17930	COG2378	regulation of single-species biofilm formation
CU648_17935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CU648_17940	COG5002	protein histidine kinase activity
CU648_17955	COG0659	secondary active sulfate transmembrane transporter activity
CU648_17970	COG0747	negative chemotaxis
CU648_17980	COG0601	transmembrane transport
CU648_17985	COG4608	Belongs to the ABC transporter superfamily
CU648_17995	COG2271	Major facilitator Superfamily
CU648_18000	COG1846	Transcriptional regulator
CU648_18005	COG0477	Major facilitator Superfamily
CU648_18010	COG1609	Transcriptional regulator
CU648_18015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CU648_18025	COG1129	ABC transporter
CU648_18030	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU648_18035	COG1879	ABC-type sugar transport system periplasmic component
CU648_18040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CU648_18060	COG1063	alcohol dehydrogenase
CU648_18075	COG3568	Endonuclease Exonuclease Phosphatase
CU648_18105	COG0840	transmembrane signaling receptor activity
CU648_18110	COG1388	LysM domain
CU648_18110	COG3584	3D domain protein
CU648_18115	COG1476	TRANSCRIPTIONal
CU648_18130	COG3104	oligopeptide transport
CU648_18135	COG1114	Component of the transport system for branched-chain amino acids
CU648_18150	COG1113	amino acid transport
CU648_18155	COG2252	PERMEase
CU648_18170	COG2153	protein acetylation
CU648_18180	COG0475	glutathione-regulated potassium exporter activity
CU648_18180	COG0569	domain protein
CU648_18195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CU648_18200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CU648_18205	COG0833	amino acid
CU648_18210	COG4990	cell redox homeostasis
CU648_18225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_18230	COG0697	spore germination
CU648_18235	COG0531	amino acid
CU648_18250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CU648_18255	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CU648_18260	COG1918	ferrous iron import across plasma membrane
CU648_18260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CU648_18265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CU648_18270	COG0573	inorganic phosphate transmembrane transporter activity
CU648_18275	COG0581	inorganic phosphate transmembrane transporter activity
CU648_18285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CU648_18405	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CU648_18430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CU648_18435	COG1116	anion transmembrane transporter activity
CU648_18440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CU648_18445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CU648_18450	COG0352	thiamine-phosphate diphosphorylase activity
CU648_18455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_18460	COG2104	thiamine diphosphate biosynthetic process
CU648_18470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_18475	COG0351	phosphomethylpyrimidine kinase
CU648_18520	COG2205	protein histidine kinase activity
CU648_18525	COG2814	Major facilitator Superfamily
CU648_18530	COG1846	Transcriptional regulator
CU648_18555	COG1136	(ABC) transporter
CU648_18555	COG0577	efflux transmembrane transporter activity
CU648_18565	COG1172	Belongs to the binding-protein-dependent transport system permease family
CU648_18580	COG2252	PERMEase
CU648_18585	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_18605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_18610	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CU648_18645	COG0778	Nitroreductase
CU648_18650	COG2719	SpoVR family
CU648_18655	COG0446	pyridine nucleotide-disulphide oxidoreductase
CU648_18660	COG1937	Protein conserved in bacteria
CU648_18665	COG0425	Belongs to the sulfur carrier protein TusA family
CU648_18665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_18670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_18670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_18675	COG0425	Belongs to the sulfur carrier protein TusA family
CU648_18685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CU648_18685	COG0425	Belongs to the sulfur carrier protein TusA family
CU648_18695	COG2210	Belongs to the sulfur carrier protein TusA family
CU648_18700	COG0730	response to heat
CU648_18710	COG1316	TRANSCRIPTIONal
CU648_18715	COG0604	alcohol dehydrogenase
CU648_18720	COG1283	sodium-dependent phosphate transmembrane transporter activity
CU648_18735	COG3711	transcriptional antiterminator
CU648_18735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CU648_18740	COG1447	Phosphotransferase system cellobiose-specific component IIA
CU648_18745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CU648_18770	COG1388	LysM domain
CU648_18770	COG3584	3D domain protein
CU648_18775	COG0577	efflux transmembrane transporter activity
CU648_18780	COG1136	(ABC) transporter
CU648_18790	COG5522	Integral membrane protein (intg_mem_TP0381)
CU648_18805	COG0577	efflux transmembrane transporter activity
CU648_18810	COG1114	Component of the transport system for branched-chain amino acids
CU648_18815	COG3546	catalase activity
CU648_18850	COG0586	Pfam SNARE associated Golgi protein
CU648_18885	COG0531	amino acid
CU648_18890	COG0475	glutathione-regulated potassium exporter activity
CU648_18900	COG1737	Transcriptional regulator
CU648_18910	COG1263	PTS System
CU648_18910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CU648_18920	COG2259	Doxx family
CU648_18940	COG1522	sequence-specific DNA binding
CU648_18950	COG2076	Multidrug Resistance protein
CU648_18955	COG2076	Multidrug Resistance protein
CU648_18960	COG1309	transcriptional regulator
CU648_18965	COG2814	Major facilitator Superfamily
CU648_18970	COG4533	DNA binding
CU648_18975	COG2211	Major facilitator Superfamily
CU648_18985	COG0693	protein deglycase activity
CU648_18990	COG0693	protein deglycase activity
CU648_18990	COG0753	catalase activity
CU648_19000	COG0531	amino acid
CU648_19015	COG1012	belongs to the aldehyde dehydrogenase family
CU648_19035	COG1132	(ABC) transporter
CU648_19040	COG1132	(ABC) transporter
CU648_19050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_19055	COG0765	amino acid transport
CU648_19060	COG1126	abc transporter atp-binding protein
CU648_19075	COG0189	ligase activity
CU648_19100	COG4585	Histidine kinase
CU648_19145	COG0028	Belongs to the TPP enzyme family
CU648_19150	COG3527	Alpha-acetolactate decarboxylase
CU648_19165	COG0561	phosphatase activity
CU648_19175	COG3409	Peptidoglycan-binding domain 1 protein
CU648_19175	COG5632	N-Acetylmuramoyl-L-alanine amidase
CU648_19185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CU648_19205	COG0659	secondary active sulfate transmembrane transporter activity
CU648_19225	COG0653	protein targeting
CU648_19230	COG2244	polysaccharide biosynthetic process
CU648_19240	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_19245	COG4196	transglutaminase domain protein
CU648_19265	COG1024	Enoyl-CoA hydratase
CU648_19285	COG1363	Peptidase, m42
CU648_19305	COG3938	Belongs to the proline racemase family
CU648_19320	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CU648_19340	COG0601	transmembrane transport
CU648_19345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_19350	COG0444	Belongs to the ABC transporter superfamily
CU648_19355	COG4608	Belongs to the ABC transporter superfamily
CU648_19365	COG0477	Major facilitator Superfamily
CU648_19370	COG3290	protein histidine kinase activity
CU648_19375	COG4565	transcriptional regulatory protein
CU648_19380	COG3181	Tripartite tricarboxylate transporter family receptor
CU648_19425	COG0210	DNA helicase
CU648_19470	COG0789	Transcriptional regulator
CU648_19470	COG4978	Transcriptional regulator
CU648_19485	COG0305	Participates in initiation and elongation during chromosome replication
CU648_19585	COG1183	phosphatidylcholine synthase activity
CU648_19620	COG2376	Dihydroxyacetone kinase
CU648_19635	COG2376	Dihydroxyacetone kinase
CU648_19640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU648_19645	COG1959	2 iron, 2 sulfur cluster binding
CU648_19680	COG0457	Tetratricopeptide repeat
CU648_19695	COG2770	Histidine kinase
CU648_19695	COG3437	response regulator, receiver
CU648_19710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_19795	COG1136	(ABC) transporter
CU648_19860	COG1191	sigma factor activity
CU648_19870	COG2208	phosphoserine phosphatase activity
CU648_19875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CU648_19880	COG2205	protein histidine kinase activity
CU648_19880	COG0784	Response regulator, receiver
CU648_19880	COG2198	Histidine kinase
CU648_19880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CU648_19905	COG0393	Putative heavy-metal-binding
CU648_19940	COG0420	3'-5' exonuclease activity
CU648_19945	COG4717	serine-type aminopeptidase activity
CU648_19975	COG0346	lactoylglutathione lyase activity
CU648_19980	COG0346	lactoylglutathione lyase activity
CU648_19985	COG0457	Tetratricopeptide repeat
CU648_19995	COG2267	carboxylic ester hydrolase activity
CU648_20025	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CU648_20030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CU648_20040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CU648_20085	COG0477	Major facilitator Superfamily
CU648_20090	COG0477	Major facilitator Superfamily
CU648_20100	COG3973	AAA domain
CU648_20105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU648_20130	COG4980	gas vesicle protein
CU648_20135	COG0537	adenosine 5'-monophosphoramidase activity
CU648_20145	COG1131	(ABC) transporter
CU648_20150	COG4473	ABC transporter
CU648_20210	COG1309	transcriptional regulator
CU648_20220	COG3402	PFAM membrane-flanked domain
CU648_20225	COG3428	Bacterial PH domain
CU648_20265	COG3402	PFAM membrane-flanked domain
CU648_20270	COG3428	Bacterial PH domain
CU648_20275	COG2329	Antibiotic biosynthesis monooxygenase
CU648_20280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_20325	COG1309	transcriptional regulator
CU648_20330	COG1511	domain protein
CU648_20350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_20355	COG1609	Transcriptional regulator
CU648_20365	COG1234	tRNA 3'-trailer cleavage
CU648_20370	COG0095	Lipoate-protein ligase
CU648_20380	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_20415	COG1408	metallophosphoesterase
CU648_20425	COG1078	dGTPase activity
CU648_20430	COG1129	ABC transporter
CU648_20450	COG1733	regulation of RNA biosynthetic process
CU648_20455	COG0477	Major facilitator Superfamily
CU648_20465	COG1595	DNA-templated transcription, initiation
CU648_20470	COG2207	Transcriptional regulator
CU648_20470	COG3708	Transcriptional regulator
CU648_20485	COG2205	protein histidine kinase activity
CU648_20490	COG0745	RESPONSE REGULATOR receiver
CU648_20515	COG0501	Belongs to the peptidase M48B family
CU648_20520	COG0697	spore germination
CU648_20535	COG0497	DNA recombination
CU648_20540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CU648_20545	COG2224	Isocitrate lyase
CU648_20555	COG1278	Cold shock
CU648_20570	COG4903	ComK protein
CU648_20575	COG0398	Pfam SNARE associated Golgi protein
CU648_20635	COG0179	Fumarylacetoacetate (FAA) hydrolase
CU648_20660	COG0367	asparagine synthase
CU648_20670	COG0753	catalase activity
CU648_20675	COG0004	ammonium transporteR
CU648_20695	COG2996	Protein conserved in bacteria
CU648_20700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU648_20710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_20725	COG0561	phosphatase activity
CU648_20740	COG0542	response to heat
CU648_20750	COG2267	carboxylic ester hydrolase activity
CU648_20770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_20775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CU648_20780	COG5504	Zn-dependent protease
CU648_20795	COG0180	Tryptophanyl-tRNA synthetase
CU648_20810	COG4166	transmembrane transport
CU648_20815	COG0601	transmembrane transport
CU648_20820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CU648_20825	COG0444	Belongs to the ABC transporter superfamily
CU648_20830	COG4608	Belongs to the ABC transporter superfamily
CU648_20835	COG0534	Mate efflux family protein
CU648_20840	COG4166	transmembrane transport
CU648_20860	COG1393	Belongs to the ArsC family
CU648_20870	COG0861	Integral membrane protein TerC family
CU648_20875	COG4862	establishment of competence for transformation
CU648_20880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_20890	COG1164	Oligoendopeptidase f
CU648_20905	COG2346	COG2346, Truncated hemoglobins
CU648_20910	COG4116	CYTH
CU648_20920	COG2357	RelA SpoT domain protein
CU648_20925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CU648_20930	COG0564	pseudouridine synthase activity
CU648_20945	COG0772	Belongs to the SEDS family
CU648_20950	COG1216	Glycosyl transferase, family 2
CU648_20970	COG0463	Glycosyl transferase, family 2
CU648_20970	COG0457	Tetratricopeptide repeat
CU648_20990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CU648_21005	COG1091	dTDP-4-dehydrorhamnose reductase activity
CU648_21050	COG2153	protein acetylation
CU648_21060	COG2382	esterase
CU648_21075	COG5492	domain, Protein
CU648_21080	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_21095	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CU648_21095	COG0512	Glutamine amidotransferase of anthranilate synthase
CU648_21130	COG1620	l-lactate permease
CU648_21135	COG5634	Uncharacterized conserved protein (DUF2278)
CU648_21195	COG0508	dehydrogenase complex catalyzes the overall conversion of
CU648_21205	COG1476	TRANSCRIPTIONal
CU648_21295	COG2226	methyltransferase
CU648_21310	COG1686	Belongs to the peptidase S11 family
CU648_21315	COG0681	Belongs to the peptidase S26 family
CU648_21350	COG1012	belongs to the aldehyde dehydrogenase family
CU648_21360	COG1176	ABC-type spermidine putrescine transport system, permease component I
CU648_21365	COG1177	transmembrane transport
CU648_21370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CU648_21380	COG2409	Drug exporters of the RND superfamily
CU648_21390	COG0564	pseudouridine synthase activity
CU648_21400	COG2340	Cysteine-rich secretory protein family
CU648_21405	COG0247	lactate metabolic process
CU648_21410	COG0277	FAD linked oxidase domain protein
CU648_21415	COG3835	regulator
CU648_21425	COG0745	RESPONSE REGULATOR receiver
CU648_21430	COG5002	protein histidine kinase activity
CU648_21435	COG2186	Transcriptional regulator
CU648_21455	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CU648_21465	COG2116	formate transmembrane transporter activity
CU648_21470	COG0861	Integral membrane protein TerC family
CU648_21475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU648_21485	COG2030	dehydratase
CU648_21505	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_21510	COG3243	poly(R)-hydroxyalkanoic acid synthase
CU648_21520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU648_21540	COG1840	ABC-type Fe3 transport system, periplasmic component
CU648_21545	COG3842	ATPase activity
CU648_21570	COG1349	DNA-binding transcription factor activity
CU648_21585	COG0235	Class ii aldolase
CU648_21595	COG2861	carbohydrate metabolic process
CU648_21605	COG3852	Histidine kinase
CU648_21610	COG1846	Transcriptional regulator
CU648_21620	COG2318	DinB family
CU648_21630	COG5002	protein histidine kinase activity
CU648_21640	COG0720	synthase
CU648_21655	COG4873	Protein conserved in bacteria
CU648_21690	COG1780	Probably involved in ribonucleotide reductase function
CU648_21700	COG1403	HNH endonuclease
CU648_21710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CU648_21715	COG1725	Transcriptional regulator
CU648_21720	COG1131	(ABC) transporter
CU648_21730	COG1131	(ABC) transporter
CU648_21735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CU648_21750	COG1522	sequence-specific DNA binding
CU648_21760	COG1335	isochorismatase
CU648_21770	COG1619	proteins homologs of microcin C7 resistance protein MccF
CU648_21775	COG2070	2-Nitropropane dioxygenase
CU648_21780	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CU648_21790	COG1696	Membrane protein involved in D-alanine export
CU648_21815	COG0716	FMN binding
CU648_21830	COG3173	Aminoglycoside phosphotransferase
CU648_21855	COG0534	Mate efflux family protein
CU648_21860	COG1968	undecaprenyl-diphosphatase activity
CU648_21875	COG1846	Transcriptional regulator
CU648_21885	COG1301	dicarboxylic acid transport
CU648_21890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CU648_21895	COG4709	membrane
CU648_21900	COG3874	Sporulation protein YtfJ
CU648_21930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_21935	COG0028	Belongs to the TPP enzyme family
CU648_21940	COG0440	acetolactate synthase activity
CU648_21980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CU648_22015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CU648_22030	COG1183	phosphatidylcholine synthase activity
CU648_22035	COG1368	sulfuric ester hydrolase activity
CU648_22045	COG0019	diaminopimelate decarboxylase activity
CU648_22065	COG0529	Catalyzes the synthesis of activated sulfate
CU648_22070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU648_22090	COG1648	precorrin-2 dehydrogenase activity
CU648_22100	COG0733	neurotransmitter:sodium symporter activity
CU648_22120	COG1757	Na H antiporter
CU648_22135	COG4758	membrane
CU648_22140	COG4585	Histidine kinase
CU648_22145	COG2197	response regulator
CU648_22155	COG1114	Component of the transport system for branched-chain amino acids
CU648_22165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CU648_22210	COG0730	response to heat
CU648_22215	COG0306	phosphate transporter
CU648_22220	COG1392	Phosphate transport regulator
CU648_22225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_22240	COG3852	Histidine kinase
CU648_22245	COG1801	Protein of unknown function DUF72
CU648_22255	COG0582	viral genome integration into host DNA
CU648_22260	COG5002	protein histidine kinase activity
CU648_22275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CU648_22275	COG0392	lysyltransferase activity
CU648_22290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CU648_22295	COG1686	Belongs to the peptidase S11 family
CU648_22300	COG2715	membrane protein required for spore maturation
CU648_22305	COG0700	Nucleoside recognition
CU648_22310	COG1187	pseudouridine synthase activity
CU648_22320	COG1333	cytochrome c biogenesis protein
CU648_22325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CU648_22330	COG0745	RESPONSE REGULATOR receiver
CU648_22335	COG5002	protein histidine kinase activity
CU648_22340	COG2096	Adenosyltransferase
CU648_22345	COG4942	peptidase
CU648_22355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CU648_22360	COG1141	Ferredoxin
CU648_22370	COG0514	ATP-dependent DNA helicase (RecQ)
CU648_22375	COG1266	CAAX protease self-immunity
CU648_22385	COG1408	metallophosphoesterase
CU648_22395	COG4862	establishment of competence for transformation
CU648_22400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CU648_22420	COG0492	ferredoxin-NADP+ reductase activity
CU648_22495	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CU648_22510	COG0142	geranyltranstransferase activity
CU648_22520	COG0142	geranyltranstransferase activity
CU648_22525	COG0105	UTP biosynthetic process
CU648_22545	COG0457	Tetratricopeptide repeat
CU648_22565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CU648_22580	COG4347	Protein of unknown function (DUF1405)
CU648_22595	COG2738	Putative neutral zinc metallopeptidase
CU648_22605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_22615	COG1694	Mazg nucleotide pyrophosphohydrolase
CU648_22630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CU648_22635	COG0438	transferase activity, transferring glycosyl groups
CU648_22675	COG1199	ATP-dependent helicase activity
CU648_22675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CU648_22695	COG3935	DnaD domain protein
CU648_22700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CU648_22710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_22710	COG4499	WXG100 protein secretion system (Wss), protein YukC
CU648_22770	COG0116	Belongs to the methyltransferase superfamily
CU648_22780	COG1199	ATP-dependent helicase activity
CU648_22785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CU648_22795	COG3173	Aminoglycoside phosphotransferase
CU648_22800	COG0024	Methionine aminopeptidase
CU648_22810	COG2233	PERMEase
CU648_22815	COG2311	Membrane
CU648_22825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CU648_22835	COG0456	acetyltransferase
CU648_22880	COG0754	glutathionylspermidine amidase activity
CU648_22895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CU648_22910	COG0454	-acetyltransferase
CU648_22930	COG0328	RNA-DNA hybrid ribonuclease activity
CU648_22970	COG1280	lysine exporter protein (LysE YggA)
CU648_22985	COG3162	membrane
CU648_22990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CU648_22995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU648_23010	COG0475	glutathione-regulated potassium exporter activity
CU648_23015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_23030	COG1196	nuclear chromosome segregation
CU648_23065	COG0640	Transcriptional regulator
CU648_23090	COG0640	Transcriptional regulator
CU648_23095	COG0798	PFAM Bile acid sodium symporter
CU648_23125	COG0789	Transcriptional regulator
CU648_23125	COG4978	Transcriptional regulator
CU648_23135	COG2323	membrane
CU648_23140	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CU648_23195	COG1923	regulation of RNA biosynthetic process
CU648_23205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CU648_23210	COG1360	Flagellar Motor Protein
CU648_23215	COG2201	protein-glutamate methylesterase activity
CU648_23220	COG0643	Histidine kinase
CU648_23220	COG2198	Histidine kinase
CU648_23225	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_23225	COG1776	CheC inhibitor of MCP methylation
CU648_23240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CU648_23260	COG1256	bacterial-type flagellum assembly
CU648_23265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_23285	COG1815	bacterial-type flagellum-dependent cell motility
CU648_23290	COG1558	bacterial-type flagellum-dependent cell motility
CU648_23295	COG1677	Flagellar hook-basal body complex protein FliE
CU648_23300	COG1766	The M ring may be actively involved in energy transduction
CU648_23305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_23315	COG1157	protein secretion by the type III secretion system
CU648_23335	COG1749	Flagellar hook protein flgE
CU648_23350	COG0835	chemotaxis
CU648_23350	COG0784	Response regulator, receiver
CU648_23360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_23365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_23365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CU648_23370	COG0741	lytic transglycosylase activity
CU648_23380	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_23385	COG1776	CheC inhibitor of MCP methylation
CU648_23385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CU648_23395	COG1338	Plays a role in the flagellum-specific transport system
CU648_23400	COG1987	bacterial-type flagellum assembly
CU648_23410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CU648_23415	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CU648_23420	COG1419	protein localization to endoplasmic reticulum
CU648_23425	COG4786	Flagellar basal body rod
CU648_23430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CU648_23455	COG1309	transcriptional regulator
CU648_23485	COG2329	Antibiotic biosynthesis monooxygenase
CU648_23515	COG3842	ATPase activity
CU648_23520	COG0725	ABC transporter, periplasmic molybdate-binding protein
CU648_23525	COG1177	transmembrane transport
CU648_23530	COG1234	tRNA 3'-trailer cleavage
CU648_23560	COG1686	Belongs to the peptidase S11 family
CU648_23565	COG0406	alpha-ribazole phosphatase activity
CU648_23580	COG1846	Transcriptional regulator
CU648_23590	COG0367	asparagine synthase
CU648_23620	COG1802	Transcriptional regulator
CU648_23625	COG0697	spore germination
CU648_23630	COG0523	cobalamin synthesis protein
CU648_23640	COG0701	Predicted permease
CU648_23655	COG1757	Na H antiporter
CU648_23660	COG0114	fumarate hydratase activity
CU648_23675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_23685	COG0534	Mate efflux family protein
CU648_23695	COG3340	Belongs to the peptidase S51 family
CU648_23715	COG0785	Cytochrome C biogenesis protein
CU648_23745	COG2733	membrane
CU648_23785	COG1131	(ABC) transporter
CU648_23800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_23805	COG0528	UMP kinase activity
CU648_23815	COG1027	Aspartate ammonia-lyase
CU648_23820	COG0281	malic enzyme
CU648_23825	COG4191	Histidine kinase
CU648_23830	COG0784	Response regulator, receiver
CU648_23835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CU648_23860	COG3620	sequence-specific DNA binding
CU648_23895	COG1051	belongs to the nudix hydrolase family
CU648_23925	COG1966	Carbon starvation protein
CU648_23935	COG1695	Transcriptional regulator
CU648_23945	COG0477	Major facilitator Superfamily
CU648_23950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_23960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CU648_23965	COG4166	transmembrane transport
CU648_23970	COG2223	nitrite transmembrane transporter activity
CU648_23975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CU648_23990	COG2244	polysaccharide biosynthetic process
CU648_23995	COG0733	neurotransmitter:sodium symporter activity
CU648_24005	COG5566	PFAM Mor transcription activator
CU648_24010	COG2323	membrane
CU648_24035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CU648_24040	COG2132	Multicopper oxidase
CU648_24050	COG5002	protein histidine kinase activity
CU648_24055	COG0745	RESPONSE REGULATOR receiver
CU648_24065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_24070	COG0028	Belongs to the TPP enzyme family
CU648_24075	COG0440	acetolactate synthase activity
CU648_24080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CU648_24090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CU648_24115	COG2814	Major facilitator Superfamily
CU648_24120	COG3384	dioxygenase
CU648_24130	COG3279	Response regulator of the LytR AlgR family
CU648_24135	COG0427	acetyl-CoA hydrolase
CU648_24170	COG4166	transmembrane transport
CU648_24220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_24240	COG1914	H( )-stimulated, divalent metal cation uptake system
CU648_24275	COG0531	amino acid
CU648_24310	COG2390	Transcriptional regulator
CU648_24320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CU648_24325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CU648_24335	COG4846	Membrane protein involved in cytochrome C biogenesis
CU648_24360	COG0006	proline dipeptidase activity
CU648_24365	COG2132	Multicopper oxidase
CU648_24415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CU648_24420	COG1114	Component of the transport system for branched-chain amino acids
CU648_24430	COG2372	response to copper ion
CU648_24430	COG1276	copper resistance
CU648_24435	COG4549	nuclear export factor GLE1
CU648_24445	COG0697	spore germination
CU648_24450	COG0583	DNA-binding transcription factor activity
CU648_24455	COG1959	2 iron, 2 sulfur cluster binding
CU648_24460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CU648_24465	COG0778	Nitroreductase
CU648_24480	COG0628	permease
CU648_24485	COG0039	L-malate dehydrogenase activity
CU648_24490	COG1231	oxidoreductase activity
CU648_24495	COG0523	cobalamin synthesis protein
CU648_24510	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_24515	COG2030	dehydratase
CU648_24520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CU648_24535	COG0411	ABC transporter
CU648_24545	COG0559	Belongs to the binding-protein-dependent transport system permease family
CU648_24555	COG0583	DNA-binding transcription factor activity
CU648_24565	COG1942	4-Oxalocrotonate Tautomerase
CU648_24585	COG1271	oxidase subunit
CU648_24590	COG1294	oxidase, subunit
CU648_24595	COG4988	ABC transporter
CU648_24600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CU648_24620	COG1686	Belongs to the peptidase S11 family
CU648_24635	COG1388	LysM domain
CU648_24635	COG0791	NLP P60 protein
CU648_24645	COG1132	(ABC) transporter
CU648_24650	COG0745	RESPONSE REGULATOR receiver
CU648_24655	COG5002	protein histidine kinase activity
CU648_24665	COG0300	oxidoreductase activity
CU648_24680	COG0726	polysaccharide deacetylase
CU648_24685	COG5658	integral membrane protein
CU648_24705	COG0460	homoserine dehydrogenase
CU648_24730	COG1316	TRANSCRIPTIONal
CU648_24740	COG0745	RESPONSE REGULATOR receiver
CU648_24745	COG5002	protein histidine kinase activity
CU648_24750	COG0726	polysaccharide deacetylase
CU648_24760	COG1285	pathogenesis
CU648_24765	COG1247	-acetyltransferase
CU648_24775	COG4264	IucA IucC family
CU648_24780	COG0318	PFAM AMP-dependent synthetase and ligase
CU648_24795	COG1082	Xylose isomerase domain protein TIM barrel
CU648_24805	COG2814	Major facilitator Superfamily
CU648_24810	COG1279	arginine transmembrane transporter activity
CU648_24825	COG1752	Esterase of the alpha-beta hydrolase superfamily
CU648_24860	COG0577	efflux transmembrane transporter activity
CU648_24865	COG2002	toxin-antitoxin pair type II binding
CU648_24870	COG1404	Belongs to the peptidase S8 family
CU648_24875	COG0640	Transcriptional regulator
CU648_24880	COG0667	Aldo Keto reductase
CU648_24885	COG2814	Major facilitator Superfamily
CU648_24910	COG0840	transmembrane signaling receptor activity
CU648_24930	COG3949	Membrane
CU648_24935	COG0783	Belongs to the Dps family
CU648_24950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CU648_24960	COG1231	oxidoreductase activity
CU648_24970	COG4989	oxidoreductase activity
CU648_24975	COG0523	cobalamin synthesis protein
CU648_24980	COG0456	acetyltransferase
CU648_24995	COG3443	Belongs to the bacterial solute-binding protein 9 family
CU648_24995	COG0803	Belongs to the bacterial solute-binding protein 9 family
CU648_25005	COG0702	epimerase
CU648_25015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CU648_25025	COG4166	transmembrane transport
CU648_25040	COG0406	alpha-ribazole phosphatase activity
CU648_25050	COG5337	Spore coat protein CotH
CU648_25055	COG1051	belongs to the nudix hydrolase family
CU648_25060	COG0586	Pfam SNARE associated Golgi protein
CU648_25065	COG2244	polysaccharide biosynthetic process
CU648_25075	COG0701	Predicted permease
CU648_25080	COG3689	TIGRFAM TIGR03943 family protein
CU648_25085	COG1607	acyl-coa hydrolase
CU648_25095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CU648_25110	COG0702	epimerase
CU648_25115	COG2839	Protein conserved in bacteria
CU648_25120	COG1253	flavin adenine dinucleotide binding
CU648_25135	COG1114	Component of the transport system for branched-chain amino acids
CU648_25140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CU648_25160	COG0860	N-Acetylmuramoyl-L-alanine amidase
CU648_25170	COG1876	peptidase activity
CU648_25180	COG0154	amidase activity
CU648_25185	COG2211	Major facilitator Superfamily
CU648_25205	COG0561	phosphatase activity
CU648_25215	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CU648_25235	COG1819	glycosyl
CU648_25240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CU648_25245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_25275	COG0456	acetyltransferase
CU648_25310	COG3874	Sporulation protein YtfJ
CU648_25335	COG2226	methyltransferase
CU648_25355	COG1082	Xylose isomerase domain protein TIM barrel
CU648_25360	COG0346	lactoylglutathione lyase activity
CU648_25370	COG0604	alcohol dehydrogenase
CU648_25375	COG1595	DNA-templated transcription, initiation
CU648_25410	COG0386	Belongs to the glutathione peroxidase family
CU648_25415	COG1305	Transglutaminase-like
CU648_25420	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CU648_25425	COG0714	Associated with various cellular activities
CU648_25440	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CU648_25445	COG1140	nitrate reductase beta subunit
CU648_25450	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CU648_25455	COG2181	nitrate reductase activity
CU648_25460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CU648_25465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CU648_25470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CU648_25475	COG0303	'Molybdopterin
CU648_25480	COG0314	molybdopterin synthase activity
CU648_25490	COG2223	nitrite transmembrane transporter activity
CU648_25500	COG1648	precorrin-2 dehydrogenase activity
CU648_25510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CU648_25510	COG1587	Uroporphyrinogen-III synthase
CU648_25515	COG2146	nitrite reductase [NAD(P)H] activity
CU648_25520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CU648_25525	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CU648_25550	COG2359	stage V sporulation protein S
CU648_25595	COG1418	mRNA catabolic process
CU648_25600	COG0488	(ABC) transporter
CU648_25615	COG0629	single-stranded DNA binding
CU648_25620	COG1413	lyase activity
CU648_25635	COG2136	Putative SAM-dependent methyltransferase
CU648_25635	COG2521	methyltransferase
CU648_25675	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CU648_25685	COG0017	Asparaginyl-tRNA synthetase
CU648_25705	COG1674	ftsk spoiiie
CU648_25760	COG1929	Belongs to the glycerate kinase type-1 family
CU648_25765	COG0471	metal ion transport
CU648_25770	COG0745	RESPONSE REGULATOR receiver
CU648_25775	COG5002	protein histidine kinase activity
CU648_25775	COG3850	Histidine kinase
CU648_25790	COG0733	neurotransmitter:sodium symporter activity
CU648_25815	COG2610	gluconate transmembrane transporter activity
CU648_25820	COG1454	alcohol dehydrogenase
CU648_25825	COG1794	racemase activity, acting on amino acids and derivatives
CU648_25835	COG0456	acetyltransferase
CU648_25840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CU648_25850	COG1131	(ABC) transporter
CU648_25855	COG4473	ABC transporter
CU648_25865	COG0546	phosphoglycolate phosphatase activity
CU648_25885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_25905	COG0768	penicillin binding
CU648_25915	COG0204	Acyl-transferase
CU648_25920	COG1272	protein, Hemolysin III
CU648_25930	COG0805	protein transport
CU648_25945	COG1307	EDD domain protein, DegV family
CU648_25950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CU648_25955	COG1999	signal sequence binding
CU648_25960	COG0071	Belongs to the small heat shock protein (HSP20) family
CU648_25965	COG0367	asparagine synthase
CU648_25990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CU648_25995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CU648_26015	COG1335	isochorismatase
CU648_26020	COG1051	belongs to the nudix hydrolase family
CU648_26025	COG0071	Belongs to the small heat shock protein (HSP20) family
CU648_26030	COG0668	transmembrane transport
CU648_26035	COG2203	Gaf domain
CU648_26035	COG4585	Histidine kinase
CU648_26040	COG2197	response regulator
CU648_26050	COG1064	alcohol dehydrogenase
CU648_26075	COG1070	Carbohydrate kinase
CU648_26110	COG1125	glycine betaine transport
CU648_26110	COG0517	IMP dehydrogenase activity
CU648_26115	COG1174	glycine betaine transport
CU648_26150	COG1253	flavin adenine dinucleotide binding
CU648_26155	COG1012	belongs to the aldehyde dehydrogenase family
CU648_26160	COG5506	Protein of unknown function (DUF1694)
CU648_26180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CU648_26185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CU648_26190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CU648_26195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CU648_26200	COG0456	acetyltransferase
CU648_26205	COG3829	transcription factor binding
CU648_26215	COG1509	lysine 2,3-aminomutase activity
CU648_26255	COG4326	sporulation control protein
CU648_26260	COG0671	phosphoesterase, PA-phosphatase related
CU648_26265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CU648_26270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CU648_26350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CU648_26385	COG0300	oxidoreductase activity
CU648_26405	COG4499	WXG100 protein secretion system (Wss), protein YukC
CU648_26405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CU648_26410	COG2814	Major facilitator Superfamily
CU648_26415	COG4841	protein insertion into membrane
CU648_26420	COG0372	Belongs to the citrate synthase family
CU648_26425	COG2079	MmgE PrpD family protein
CU648_26430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CU648_26435	COG1960	acyl-CoA dehydrogenase activity
CU648_26440	COG2084	Dehydrogenase
CU648_26445	COG1012	belongs to the aldehyde dehydrogenase family
CU648_26450	COG1280	lysine exporter protein (LysE YggA)
CU648_26455	COG1024	Enoyl-CoA hydratase
CU648_26470	COG0420	3'-5' exonuclease activity
CU648_26475	COG0419	ATPase involved in DNA repair
CU648_26505	COG2223	nitrite transmembrane transporter activity
CU648_26515	COG1028	Short-chain dehydrogenase reductase Sdr
CU648_26520	COG1169	isochorismate synthase
CU648_26525	COG1021	2,3-dihydroxybenzoate-AMP ligase
CU648_26530	COG1535	isochorismatase
CU648_26530	COG3433	isochorismatase activity
CU648_26535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CU648_26540	COG3251	PFAM MbtH domain protein
CU648_26545	COG2814	Major facilitator Superfamily
CU648_26560	COG0776	regulation of translation
CU648_26570	COG2318	DinB family
CU648_26580	COG1115	amino acid carrier protein
CU648_26595	COG2329	Antibiotic biosynthesis monooxygenase
CU648_26600	COG1187	pseudouridine synthase activity
CU648_26605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CU648_26610	COG1136	(ABC) transporter
CU648_26625	COG0596	Alpha beta hydrolase
CU648_26630	COG2814	Major facilitator Superfamily
CU648_26650	COG2226	methyltransferase
CU648_26685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_26720	COG1247	-acetyltransferase
CU648_26730	COG0640	Transcriptional regulator
CU648_26750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CU648_26755	COG0589	response to stress
CU648_26760	COG0659	secondary active sulfate transmembrane transporter activity
CU648_26770	COG1695	Transcriptional regulator
CU648_26780	COG0640	Transcriptional regulator
CU648_26785	COG0798	PFAM Bile acid sodium symporter
CU648_26865	COG2226	methyltransferase
CU648_26870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CU648_26880	COG1278	Cold shock
CU648_26895	COG0010	Belongs to the arginase family
CU648_26905	COG0583	DNA-binding transcription factor activity
CU648_26910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CU648_26925	COG0583	DNA-binding transcription factor activity
CU648_26930	COG2258	MOSC domain
CU648_26945	COG1132	(ABC) transporter
CU648_26950	COG1132	(ABC) transporter
CU648_26970	COG1396	sequence-specific DNA binding
CU648_27000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CU648_27015	COG1595	DNA-templated transcription, initiation
CU648_27045	COG1649	PFAM Uncharacterised BCR, COG1649
CU648_27075	COG2971	BadF BadG BcrA BcrD
CU648_27085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CU648_27150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CU648_27180	COG1309	transcriptional regulator
CU648_27195	COG0577	efflux transmembrane transporter activity
CU648_27195	COG1136	(ABC) transporter
CU648_27200	COG0500	methyltransferase
CU648_27200	COG3615	Tellurite resistance protein tehB
CU648_27210	COG3961	Belongs to the TPP enzyme family
CU648_27215	COG1846	Transcriptional regulator
CU648_27250	COG2195	Cleaves the N-terminal amino acid of tripeptides
CU648_27265	COG1595	DNA-templated transcription, initiation
CU648_27275	COG0768	penicillin binding
CU648_27285	COG2367	Beta-lactamase
CU648_27290	COG1408	metallophosphoesterase
CU648_27325	COG1960	acyl-CoA dehydrogenase activity
CU648_27330	COG0439	Biotin carboxylase
CU648_27335	COG0511	ligase activity, forming carbon-carbon bonds
CU648_27340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CU648_27345	COG1024	Enoyl-CoA hydratase
CU648_27350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CU648_27355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CU648_27365	COG1247	-acetyltransferase
CU648_27370	COG0572	uridine kinase
CU648_27375	COG2318	DinB family
CU648_27380	COG1686	Belongs to the peptidase S11 family
CU648_27405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CU648_27425	COG3227	Zinc metalloprotease (Elastase)
CU648_27445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU648_27445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CU648_27460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_27510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_27530	COG1063	alcohol dehydrogenase
CU648_27555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CU648_27570	COG3773	Cell wall hydrolase
CU648_27580	COG0745	RESPONSE REGULATOR receiver
CU648_27585	COG2205	protein histidine kinase activity
CU648_27605	COG1136	(ABC) transporter
CU648_27610	COG0577	efflux transmembrane transporter activity
CU648_27630	COG0460	homoserine dehydrogenase
CU648_27635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_27645	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CU648_27745	COG2124	cytochrome p450
CU648_27780	COG0561	phosphatase activity
CU648_27815	COG5002	protein histidine kinase activity
CU648_27825	COG1819	glycosyl
CU648_27830	COG1794	racemase activity, acting on amino acids and derivatives
CU648_27855	COG2205	protein histidine kinase activity
CU648_27865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CU648_27870	COG0604	alcohol dehydrogenase
CU648_27875	COG0671	phosphoesterase, PA-phosphatase related
CU648_27895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CU648_27930	COG0693	protein deglycase activity
CU648_27960	COG2814	Major facilitator Superfamily
CU648_27980	COG0584	glycerophosphoryl diester phosphodiesterase
CU648_28000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CU648_28005	COG0697	spore germination
CU648_28035	COG2223	nitrite transmembrane transporter activity
CU648_28040	COG2816	NAD+ diphosphatase activity
CU648_28045	COG0592	DNA-directed DNA polymerase activity
CU648_28050	COG2816	NAD+ diphosphatase activity
CU648_28080	COG3878	Protein conserved in bacteria
CU648_28100	COG4667	esterase of the alpha-beta hydrolase superfamily
CU648_28125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CU648_28140	COG0322	excinuclease ABC activity
CU648_28185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CU648_28235	COG1523	belongs to the glycosyl hydrolase 13 family
CU648_28240	COG3227	Zinc metalloprotease (Elastase)
CU648_28260	COG0201	protein transport