locus-tag	class	description
IM538_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IM538_00010	COG0592	DNA-directed DNA polymerase activity
IM538_00015	COG2501	S4 domain
IM538_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IM538_00030	COG0187	DNA topoisomerase II activity
IM538_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IM538_00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IM538_00080	COG0516	GMP reductase activity
IM538_00080	COG0517	IMP dehydrogenase activity
IM538_00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IM538_00100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IM538_00110	COG1428	Deoxynucleoside kinase
IM538_00115	COG1428	Deoxynucleoside kinase
IM538_00120	COG1388	LysM domain
IM538_00120	COG3858	chitin binding
IM538_00125	COG1335	isochorismatase
IM538_00130	COG0590	tRNA wobble adenosine to inosine editing
IM538_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IM538_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IM538_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IM538_00205	COG1982	Orn Lys Arg decarboxylase major
IM538_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IM538_00215	COG3870	Protein conserved in bacteria
IM538_00220	COG1728	Protein conserved in bacteria
IM538_00225	COG0470	DNA polymerase III
IM538_00230	COG1774	PSP1 C-terminal conserved region
IM538_00235	COG4467	Involved in initiation control of chromosome replication
IM538_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IM538_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IM538_00250	COG2002	toxin-antitoxin pair type II binding
IM538_00260	COG0084	hydrolase, TatD family'
IM538_00265	COG3583	domain protein
IM538_00265	COG3584	3D domain protein
IM538_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IM538_00285	COG4466	Protein conserved in bacteria
IM538_00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IM538_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IM538_00305	COG0251	oxidation-reduction process
IM538_00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IM538_00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IM538_00330	COG0193	aminoacyl-tRNA hydrolase activity
IM538_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IM538_00345	COG2002	toxin-antitoxin pair type II binding
IM538_00350	COG2244	polysaccharide biosynthetic process
IM538_00355	COG3956	TIGRFAM MazG family protein
IM538_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IM538_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IM538_00380	COG1098	S1 RNA binding domain
IM538_00395	COG2208	phosphoserine phosphatase activity
IM538_00400	COG2304	oxidoreductase activity
IM538_00405	COG0515	serine threonine protein kinase
IM538_00410	COG0037	tRNA processing
IM538_00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IM538_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IM538_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IM538_00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IM538_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IM538_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IM538_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IM538_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
IM538_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IM538_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IM538_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IM538_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IM538_00475	COG1396	sequence-specific DNA binding
IM538_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IM538_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IM538_00565	COG1285	pathogenesis
IM538_00575	COG3880	PFAM UvrB UvrC protein
IM538_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IM538_00585	COG0542	response to heat
IM538_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IM538_00600	COG4956	integral membrane protein (PIN domain superfamily)
IM538_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IM538_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IM538_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IM538_00620	COG1045	serine acetyltransferase
IM538_00625	COG0215	cysteine-tRNA ligase activity
IM538_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM538_00640	COG3688	RNA-binding protein containing a PIN domain
IM538_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM538_00660	COG0250	Participates in transcription elongation, termination and antitermination
IM538_00665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IM538_00670	COG0081	regulation of translation
IM538_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IM538_00680	COG0222	ribosome binding
IM538_00685	COG2813	Specifically methylates the guanine in position
IM538_00690	COG0085	RNA polymerase activity
IM538_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IM538_00700	COG1358	cellular component organization or biogenesis
IM538_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IM538_00710	COG0049	tRNA binding
IM538_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IM538_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IM538_00735	COG0088	Forms part of the polypeptide exit tunnel
IM538_00740	COG0089	rRNA binding
IM538_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IM538_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IM538_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IM538_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
IM538_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IM538_00785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IM538_00795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IM538_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IM538_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IM538_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IM538_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IM538_00820	COG1841	ribosomal large subunit assembly
IM538_00830	COG0201	protein transport
IM538_00835	COG0563	adenylate kinase activity
IM538_00840	COG0024	Methionine aminopeptidase
IM538_00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
IM538_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IM538_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IM538_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IM538_00870	COG0202	RNA polymerase activity
IM538_00880	COG1122	ATPase activity
IM538_00885	COG1122	ATPase activity
IM538_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IM538_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IM538_00910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM538_00915	COG0765	amino acid transport
IM538_00920	COG1126	abc transporter atp-binding protein
IM538_00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
IM538_00940	COG0489	protein tyrosine kinase activity
IM538_00950	COG2194	sulfuric ester hydrolase activity
IM538_00955	COG0726	polysaccharide deacetylase
IM538_01040	COG1595	DNA-templated transcription, initiation
IM538_01045	COG5662	AntiSigma factor
IM538_01050	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IM538_01055	COG4856	YbbR-like protein
IM538_01060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IM538_01065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IM538_01070	COG1309	transcriptional regulator
IM538_01075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IM538_01090	COG0601	transmembrane transport
IM538_01095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_01125	COG1253	flavin adenine dinucleotide binding
IM538_01130	COG1181	Belongs to the D-alanine--D-alanine ligase family
IM538_01135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IM538_01145	COG0513	Belongs to the DEAD box helicase family
IM538_01150	COG1970	mechanosensitive ion channel activity
IM538_01155	COG4294	response to UV
IM538_01160	COG3402	PFAM membrane-flanked domain
IM538_01165	COG3428	Bacterial PH domain
IM538_01170	COG0705	Rhomboid family
IM538_01175	COG0736	holo-[acyl-carrier-protein] synthase activity
IM538_01180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IM538_01185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IM538_01190	COG0864	Transcriptional regulator
IM538_01195	COG2337	Toxic component of a toxin-antitoxin (TA) module
IM538_01205	COG1191	sigma factor activity
IM538_01210	COG2183	response to ionizing radiation
IM538_01220	COG3091	SprT-like family
IM538_01310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IM538_01315	COG0802	atpase or kinase
IM538_01320	COG1214	PFAM Peptidase M22, glycoprotease
IM538_01325	COG0456	acetyltransferase
IM538_01335	COG0488	(ABC) transporter
IM538_01345	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IM538_01350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IM538_01355	COG0805	protein transport
IM538_01365	COG1266	CAAX protease self-immunity
IM538_01370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IM538_01375	COG0459	protein refolding
IM538_01380	COG0840	transmembrane signaling receptor activity
IM538_01385	COG0017	Asparaginyl-tRNA synthetase
IM538_01400	COG0473	3-isopropylmalate dehydrogenase activity
IM538_01405	COG0714	Associated with various cellular activities
IM538_01410	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
IM538_01415	COG1305	Transglutaminase-like
IM538_01420	COG0519	Catalyzes the synthesis of GMP from XMP
IM538_01420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IM538_01425	COG2252	PERMEase
IM538_01455	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IM538_01465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IM538_01470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IM538_01475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IM538_01480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IM538_01485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IM538_01490	COG0047	phosphoribosylformylglycinamidine synthase activity
IM538_01495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IM538_01500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IM538_01505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IM538_01510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IM538_01520	COG0151	Belongs to the GarS family
IM538_01535	COG1470	cell adhesion involved in biofilm formation
IM538_01540	COG4496	protein, YerC YecD
IM538_01545	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IM538_01550	COG0210	DNA helicase
IM538_01555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IM538_01560	COG4851	CamS sex pheromone cAM373 precursor
IM538_01565	COG1012	belongs to the aldehyde dehydrogenase family
IM538_01570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IM538_01580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IM538_01585	COG0154	amidase activity
IM538_01605	COG1597	lipid kinase activity
IM538_01625	COG5002	protein histidine kinase activity
IM538_01625	COG0784	Response regulator, receiver
IM538_01630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IM538_01635	COG4191	Histidine kinase
IM538_01640	COG1191	sigma factor activity
IM538_01650	COG2814	Major facilitator Superfamily
IM538_01655	COG0346	lactoylglutathione lyase activity
IM538_01660	COG4213	ABC transporter substrate-binding protein
IM538_01670	COG4214	carbohydrate transport
IM538_01680	COG2972	Histidine kinase
IM538_01685	COG2197	response regulator
IM538_01690	COG4213	ABC transporter substrate-binding protein
IM538_01695	COG0673	inositol 2-dehydrogenase activity
IM538_01705	COG0477	Major facilitator Superfamily
IM538_01710	COG2910	NAD(P)H-binding
IM538_01715	COG0697	spore germination
IM538_01740	COG2814	Major facilitator Superfamily
IM538_01745	COG2861	carbohydrate metabolic process
IM538_01750	COG1376	ErfK ybiS ycfS ynhG family protein
IM538_01760	COG1263	PTS System
IM538_01760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IM538_01765	COG0366	Alpha amylase catalytic
IM538_01770	COG2190	(PTS) system
IM538_01780	COG2267	carboxylic ester hydrolase activity
IM538_01785	COG0577	efflux transmembrane transporter activity
IM538_01790	COG1136	(ABC) transporter
IM538_01795	COG2205	protein histidine kinase activity
IM538_01800	COG0745	RESPONSE REGULATOR receiver
IM538_01805	COG1078	dGTPase activity
IM538_01810	COG1309	transcriptional regulator
IM538_01815	COG2814	Major facilitator Superfamily
IM538_01830	COG0456	acetyltransferase
IM538_01840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IM538_01850	COG2814	Major facilitator Superfamily
IM538_01875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IM538_01880	COG1309	transcriptional regulator
IM538_01885	COG1131	(ABC) transporter
IM538_01900	COG4585	Histidine kinase
IM538_01905	COG2197	response regulator
IM538_01925	COG2832	Protein of unknown function (DUF454)
IM538_01940	COG5002	protein histidine kinase activity
IM538_01945	COG2270	Major facilitator Superfamily
IM538_01955	COG4187	Peptidase family M20/M25/M40
IM538_01975	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
IM538_01980	COG3853	Toxic anion resistance protein (TelA)
IM538_01985	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_01990	COG0166	Belongs to the GPI family
IM538_02000	COG2195	Cleaves the N-terminal amino acid of tripeptides
IM538_02020	COG4187	Peptidase family M20/M25/M40
IM538_02035	COG2094	Belongs to the DNA glycosylase MPG family
IM538_02045	COG1842	Phage shock protein A
IM538_02055	COG4585	Histidine kinase
IM538_02060	COG2197	response regulator
IM538_02095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IM538_02100	COG2146	nitrite reductase [NAD(P)H] activity
IM538_02105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IM538_02105	COG1587	Uroporphyrinogen-III synthase
IM538_02115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IM538_02115	COG1648	precorrin-2 dehydrogenase activity
IM538_02120	COG0513	Belongs to the DEAD box helicase family
IM538_02125	COG0702	epimerase
IM538_02130	COG4895	conserved protein (DUF2196)
IM538_02140	COG0584	glycerophosphoryl diester phosphodiesterase
IM538_02145	COG2124	cytochrome p450
IM538_02150	COG3973	AAA domain
IM538_02160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IM538_02165	COG0805	protein transport
IM538_02170	COG0488	(ABC) transporter
IM538_02190	COG0860	N-Acetylmuramoyl-L-alanine amidase
IM538_02200	COG2244	polysaccharide biosynthetic process
IM538_02205	COG0488	(ABC) transporter
IM538_02215	COG1077	Cell shape determining protein MreB Mrl
IM538_02240	COG1131	(ABC) transporter
IM538_02255	COG4840	Belongs to the UPF0435 family
IM538_02260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM538_02270	COG1295	ribonuclease BN
IM538_02275	COG2217	Heavy metal translocating P-type atpase
IM538_02285	COG0477	Major facilitator Superfamily
IM538_02295	COG2364	Membrane
IM538_02305	COG0535	radical SAM domain protein
IM538_02330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IM538_02340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IM538_02345	COG0840	transmembrane signaling receptor activity
IM538_02350	COG2971	BadF BadG BcrA BcrD
IM538_02355	COG3876	Protein conserved in bacteria
IM538_02360	COG2385	sporulation resulting in formation of a cellular spore
IM538_02365	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IM538_02380	COG0395	ABC-type sugar transport system, permease component
IM538_02385	COG1472	Belongs to the glycosyl hydrolase 3 family
IM538_02390	COG1737	Transcriptional regulator
IM538_02395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IM538_02400	COG1472	Belongs to the glycosyl hydrolase 3 family
IM538_02410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IM538_02415	COG0363	glucosamine-6-phosphate deaminase activity
IM538_02430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IM538_02440	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IM538_02470	COG3842	ATPase activity
IM538_02475	COG0395	ABC-type sugar transport system, permease component
IM538_02480	COG1840	ABC-type Fe3 transport system, periplasmic component
IM538_02490	COG1164	Oligoendopeptidase f
IM538_02495	COG1525	nuclease
IM538_02505	COG1012	belongs to the aldehyde dehydrogenase family
IM538_02510	COG1454	alcohol dehydrogenase
IM538_02515	COG1846	Transcriptional regulator
IM538_02520	COG0386	Belongs to the glutathione peroxidase family
IM538_02525	COG2066	Belongs to the glutaminase family
IM538_02535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IM538_02540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM538_02560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM538_02565	COG1845	cytochrome c oxidase, subunit III
IM538_02570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IM538_02590	COG1388	LysM domain
IM538_02590	COG3409	Peptidoglycan-binding domain 1 protein
IM538_02590	COG5632	N-Acetylmuramoyl-L-alanine amidase
IM538_02615	COG1090	epimerase
IM538_02620	COG2137	regulation of response to DNA damage stimulus
IM538_02625	COG0300	oxidoreductase activity
IM538_02650	COG1988	membrane-bound metal-dependent
IM538_02660	COG1194	a g-specific adenine glycosylase
IM538_02670	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_02685	COG3557	Belongs to the UPF0374 family
IM538_02690	COG1132	(ABC) transporter
IM538_02695	COG4608	Belongs to the ABC transporter superfamily
IM538_02700	COG0444	Belongs to the ABC transporter superfamily
IM538_02705	COG0601	transmembrane transport
IM538_02710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_02720	COG4129	membrane
IM538_02725	COG0070	glutamate synthase
IM538_02725	COG0069	glutamate synthase activity
IM538_02725	COG0067	glutamate synthase
IM538_02730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IM538_02740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IM538_02745	COG2096	Adenosyltransferase
IM538_02750	COG0735	belongs to the Fur family
IM538_02860	COG1073	alpha beta
IM538_02870	COG0668	transmembrane transport
IM538_02875	COG4451	ribulose bisphosphate carboxylase, small
IM538_02875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IM538_02900	COG1131	(ABC) transporter
IM538_02930	COG1396	sequence-specific DNA binding
IM538_02960	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM538_03000	COG0791	NLP P60 protein
IM538_03045	COG1595	DNA-templated transcription, initiation
IM538_03055	COG3708	Transcriptional regulator
IM538_03055	COG2207	Transcriptional regulator
IM538_03090	COG1733	regulation of RNA biosynthetic process
IM538_03095	COG2514	catechol 2,3-dioxygenase activity
IM538_03130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IM538_03135	COG1408	metallophosphoesterase
IM538_03160	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_03175	COG0657	acetylesterase activity
IM538_03185	COG3339	Conserved Protein
IM538_03260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IM538_03265	COG1335	isochorismatase
IM538_03295	COG1522	sequence-specific DNA binding
IM538_03300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IM538_03315	COG0737	Belongs to the 5'-nucleotidase family
IM538_03315	COG4085	toxin activity
IM538_03315	COG1525	nuclease
IM538_03335	COG2972	Histidine kinase
IM538_03350	COG0673	inositol 2-dehydrogenase activity
IM538_03355	COG0673	inositol 2-dehydrogenase activity
IM538_03375	COG0697	spore germination
IM538_03400	COG3382	B3 4 domain protein
IM538_03430	COG2766	serine protein kinase
IM538_03435	COG2718	Belongs to the UPF0229 family
IM538_03445	COG0833	amino acid
IM538_03455	COG0823	Involved in the tonB-independent uptake of proteins
IM538_03455	COG1506	peptidase
IM538_03455	COG4946	Tricorn protease homolog
IM538_03460	COG1329	Transcriptional regulator
IM538_03465	COG1278	Cold shock
IM538_03480	COG1476	TRANSCRIPTIONal
IM538_03490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IM538_03505	COG0659	secondary active sulfate transmembrane transporter activity
IM538_03510	COG0589	response to stress
IM538_03525	COG0659	secondary active sulfate transmembrane transporter activity
IM538_03530	COG0589	response to stress
IM538_03535	COG0589	response to stress
IM538_03540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IM538_03545	COG3311	Transcriptional regulator
IM538_03550	COG0517	IMP dehydrogenase activity
IM538_03555	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_03560	COG0655	NAD(P)H dehydrogenase (quinone) activity
IM538_03565	COG1285	pathogenesis
IM538_03570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IM538_03575	COG1070	Carbohydrate kinase
IM538_03580	COG1737	Transcriptional regulator
IM538_03585	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IM538_03590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IM538_03595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IM538_03595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IM538_03600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IM538_03600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IM538_03605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IM538_03610	COG0800	Aldolase
IM538_03615	COG4948	Mandelate Racemase Muconate Lactonizing
IM538_03625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IM538_03630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IM538_03635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IM538_03655	COG3852	Histidine kinase
IM538_03665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IM538_03675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IM538_03680	COG2720	vancomycin resistance protein
IM538_03685	COG0372	Belongs to the citrate synthase family
IM538_03690	COG0583	DNA-binding transcription factor activity
IM538_03705	COG1368	sulfuric ester hydrolase activity
IM538_03715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM538_03720	COG0730	response to heat
IM538_03730	COG0561	phosphatase activity
IM538_03735	COG0564	pseudouridine synthase activity
IM538_03750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IM538_03755	COG0366	Alpha amylase catalytic
IM538_03760	COG0517	IMP dehydrogenase activity
IM538_03765	COG3153	acetyltransferase
IM538_03765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IM538_03780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IM538_03785	COG4221	oxidoreductase activity
IM538_03790	COG4585	Histidine kinase
IM538_03790	COG2203	Gaf domain
IM538_03795	COG2197	response regulator
IM538_03800	COG0431	NADPH-dependent FMN reductase
IM538_03870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IM538_04150	COG1686	Belongs to the peptidase S11 family
IM538_04155	COG0753	catalase activity
IM538_04160	COG1846	Transcriptional regulator
IM538_04165	COG0400	carboxylic ester hydrolase activity
IM538_04170	COG0640	Transcriptional regulator
IM538_04180	COG0765	amino acid transport
IM538_04185	COG1126	abc transporter atp-binding protein
IM538_04190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IM538_04200	COG4758	membrane
IM538_04205	COG4585	Histidine kinase
IM538_04210	COG2197	response regulator
IM538_04225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM538_04230	COG1585	Membrane protein implicated in regulation of membrane protease activity
IM538_04235	COG2268	Band 7 protein
IM538_04245	COG1595	DNA-templated transcription, initiation
IM538_04265	COG0393	Putative heavy-metal-binding
IM538_04270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IM538_04275	COG4721	ABC-type cobalt transport system, permease component
IM538_04280	COG1122	ATPase activity
IM538_04285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IM538_04290	COG0352	thiamine-phosphate diphosphorylase activity
IM538_04295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IM538_04300	COG2104	thiamine diphosphate biosynthetic process
IM538_04305	COG2022	thiamine diphosphate biosynthetic process
IM538_04310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IM538_04315	COG0351	phosphomethylpyrimidine kinase
IM538_04325	COG1132	(ABC) transporter
IM538_04330	COG1132	(ABC) transporter
IM538_04335	COG2346	COG2346, Truncated hemoglobins
IM538_04340	COG1253	flavin adenine dinucleotide binding
IM538_04370	COG3842	ATPase activity
IM538_04375	COG2508	Transcriptional regulator
IM538_04390	COG0189	ligase activity
IM538_04395	COG0189	ligase activity
IM538_04400	COG0189	ligase activity
IM538_04410	COG4399	Belongs to the UPF0754 family
IM538_04420	COG0561	phosphatase activity
IM538_04425	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IM538_04440	COG1960	acyl-CoA dehydrogenase activity
IM538_04445	COG0318	PFAM AMP-dependent synthetase and ligase
IM538_04450	COG1250	3-hydroxyacyl-CoA dehydrogenase
IM538_04455	COG0183	Belongs to the thiolase family
IM538_04460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_04465	COG1024	Enoyl-CoA hydratase
IM538_04475	COG4152	abc transporter atp-binding protein
IM538_04480	COG1668	transmembrane transport
IM538_04500	COG0071	Belongs to the small heat shock protein (HSP20) family
IM538_04510	COG0420	3'-5' exonuclease activity
IM538_04515	COG4717	serine-type aminopeptidase activity
IM538_04520	COG3481	metal-dependent phosphohydrolase, HD sub domain
IM538_04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IM538_04560	COG1846	Transcriptional regulator
IM538_04565	COG4980	gas vesicle protein
IM538_04580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IM538_04585	COG0537	adenosine 5'-monophosphoramidase activity
IM538_04590	COG1131	(ABC) transporter
IM538_04595	COG4473	ABC transporter
IM538_04605	COG1473	amidohydrolase
IM538_04610	COG0671	phosphoesterase, PA-phosphatase related
IM538_04625	COG0673	inositol 2-dehydrogenase activity
IM538_04640	COG1113	amino acid transport
IM538_04645	COG1280	lysine exporter protein (LysE YggA)
IM538_04655	COG3706	GGDEF domain
IM538_04660	COG5577	PFAM Coat F domain
IM538_04670	COG1063	alcohol dehydrogenase
IM538_04675	COG5577	PFAM Coat F domain
IM538_04685	COG1115	amino acid carrier protein
IM538_04695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM538_04700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IM538_04705	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IM538_04710	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IM538_04715	COG1609	Transcriptional regulator
IM538_04725	COG1234	tRNA 3'-trailer cleavage
IM538_04730	COG0318	PFAM AMP-dependent synthetase and ligase
IM538_04735	COG2226	methyltransferase
IM538_04740	COG1024	Enoyl-CoA hydratase
IM538_04745	COG3546	catalase activity
IM538_04750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IM538_04765	COG0501	Belongs to the peptidase M48B family
IM538_04770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IM538_04775	COG2224	Isocitrate lyase
IM538_04805	COG4903	ComK protein
IM538_04815	COG0823	Involved in the tonB-independent uptake of proteins
IM538_04815	COG1506	peptidase
IM538_04815	COG4946	Tricorn protease homolog
IM538_04835	COG0398	Pfam SNARE associated Golgi protein
IM538_04855	COG0411	ABC transporter
IM538_04880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IM538_04890	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_04895	COG0183	Belongs to the thiolase family
IM538_04900	COG0318	PFAM AMP-dependent synthetase and ligase
IM538_04930	COG2368	4-hydroxyphenylacetate
IM538_04940	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IM538_04985	COG2311	Membrane
IM538_05025	COG0455	bacterial-type flagellum organization
IM538_05045	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM538_05050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IM538_05060	COG5001	Diguanylate cyclase
IM538_05060	COG3300	MHYT domain
IM538_05070	COG0367	asparagine synthase
IM538_05075	COG0534	Mate efflux family protein
IM538_05085	COG2182	Extracellular solute-binding protein
IM538_05090	COG1175	transmembrane transport
IM538_05095	COG3833	ABC-type maltose transport systems, permease component
IM538_05100	COG0366	Alpha amylase catalytic
IM538_05100	COG1874	Beta-galactosidase
IM538_05110	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_05120	COG0646	methionine synthase
IM538_05120	COG1410	methionine synthase
IM538_05125	COG0646	methionine synthase
IM538_05125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IM538_05130	COG1666	GTP binding
IM538_05135	COG2996	Protein conserved in bacteria
IM538_05145	COG1307	EDD domain protein, DegV family
IM538_05150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IM538_05170	COG0561	phosphatase activity
IM538_05175	COG1073	alpha beta
IM538_05180	COG2151	metal-sulfur cluster biosynthetic enzyme
IM538_05185	COG2151	metal-sulfur cluster biosynthetic enzyme
IM538_05215	COG0746	molybdenum cofactor guanylyltransferase activity
IM538_05220	COG0535	radical SAM domain protein
IM538_05225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IM538_05230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IM538_05235	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IM538_05240	COG0303	'Molybdopterin
IM538_05245	COG1763	Mo-molybdopterin cofactor biosynthetic process
IM538_05250	COG0314	molybdopterin synthase activity
IM538_05255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IM538_05270	COG1968	undecaprenyl-diphosphatase activity
IM538_05280	COG0542	response to heat
IM538_05290	COG2267	carboxylic ester hydrolase activity
IM538_05300	COG1744	ABC transporter substrate-binding protein PnrA-like
IM538_05315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IM538_05320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IM538_05335	COG5504	Zn-dependent protease
IM538_05345	COG0444	Belongs to the ABC transporter superfamily
IM538_05350	COG4608	Belongs to the ABC transporter superfamily
IM538_05355	COG0747	negative chemotaxis
IM538_05360	COG0601	transmembrane transport
IM538_05365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_05370	COG0444	Belongs to the ABC transporter superfamily
IM538_05375	COG4608	Belongs to the ABC transporter superfamily
IM538_05385	COG0601	transmembrane transport
IM538_05390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_05400	COG0840	transmembrane signaling receptor activity
IM538_05405	COG0180	Tryptophanyl-tRNA synthetase
IM538_05415	COG4166	transmembrane transport
IM538_05420	COG0601	transmembrane transport
IM538_05425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_05430	COG0444	Belongs to the ABC transporter superfamily
IM538_05435	COG4608	Belongs to the ABC transporter superfamily
IM538_05450	COG0456	acetyltransferase
IM538_05455	COG1393	Belongs to the ArsC family
IM538_05460	COG0861	Integral membrane protein TerC family
IM538_05465	COG4862	establishment of competence for transformation
IM538_05470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IM538_05475	COG4469	Competence protein
IM538_05485	COG1164	Oligoendopeptidase f
IM538_05490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IM538_05495	COG2346	COG2346, Truncated hemoglobins
IM538_05500	COG3706	GGDEF domain
IM538_05505	COG0741	lytic transglycosylase activity
IM538_05510	COG4116	CYTH
IM538_05520	COG2357	RelA SpoT domain protein
IM538_05530	COG0564	pseudouridine synthase activity
IM538_05540	COG0772	Belongs to the SEDS family
IM538_05545	COG2239	Acts as a magnesium transporter
IM538_05550	COG0569	domain protein
IM538_05550	COG0475	glutathione-regulated potassium exporter activity
IM538_05560	COG2200	EAL domain
IM538_05730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IM538_05745	COG2323	membrane
IM538_05760	COG0210	DNA helicase
IM538_05770	COG3852	Histidine kinase
IM538_05785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM538_05790	COG2323	membrane
IM538_05795	COG2153	protein acetylation
IM538_05800	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IM538_05805	COG2382	esterase
IM538_05820	COG1464	Belongs to the NlpA lipoprotein family
IM538_05825	COG1999	signal sequence binding
IM538_05835	COG2358	TRAP transporter, solute receptor (TAXI family
IM538_05855	COG4191	Histidine kinase
IM538_05870	COG1937	Protein conserved in bacteria
IM538_05875	COG0425	Belongs to the sulfur carrier protein TusA family
IM538_05880	COG2210	Belongs to the sulfur carrier protein TusA family
IM538_05885	COG1054	Belongs to the UPF0176 family
IM538_05890	COG0425	Belongs to the sulfur carrier protein TusA family
IM538_05890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM538_05895	COG0425	Belongs to the sulfur carrier protein TusA family
IM538_05895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM538_05900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM538_05900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM538_05905	COG0425	Belongs to the sulfur carrier protein TusA family
IM538_05910	COG0730	response to heat
IM538_05915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM538_05975	COG3285	dna ligase
IM538_05975	COG1793	dna ligase
IM538_05980	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IM538_05985	COG0586	Pfam SNARE associated Golgi protein
IM538_05990	COG0861	Integral membrane protein TerC family
IM538_06000	COG1191	sigma factor activity
IM538_06020	COG0501	Belongs to the peptidase M48B family
IM538_06030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IM538_06035	COG2814	Major facilitator Superfamily
IM538_06070	COG0840	transmembrane signaling receptor activity
IM538_06075	COG5002	protein histidine kinase activity
IM538_06080	COG0586	Pfam SNARE associated Golgi protein
IM538_06085	COG2258	MOSC domain
IM538_06090	COG0640	Transcriptional regulator
IM538_06095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IM538_06100	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IM538_06105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IM538_06110	COG0436	Aminotransferase
IM538_06115	COG1850	ribulose-bisphosphate carboxylase activity
IM538_06120	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IM538_06125	COG0235	Class ii aldolase
IM538_06130	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IM538_06135	COG0346	lactoylglutathione lyase activity
IM538_06160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IM538_06165	COG0644	oxidoreductase
IM538_06180	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IM538_06185	COG2223	nitrite transmembrane transporter activity
IM538_06190	COG0667	Aldo Keto reductase
IM538_06195	COG3852	Histidine kinase
IM538_06200	COG0483	inositol monophosphate 1-phosphatase activity
IM538_06210	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IM538_06215	COG3639	organic phosphonate transmembrane transporter activity
IM538_06220	COG3639	organic phosphonate transmembrane transporter activity
IM538_06225	COG0737	Belongs to the 5'-nucleotidase family
IM538_06230	COG0697	spore germination
IM538_06260	COG1360	Flagellar Motor Protein
IM538_06265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IM538_06290	COG4585	Histidine kinase
IM538_06295	COG2197	response regulator
IM538_06305	COG1376	ErfK ybiS ycfS ynhG family protein
IM538_06320	COG1309	transcriptional regulator
IM538_06355	COG0697	spore germination
IM538_06365	COG0582	viral genome integration into host DNA
IM538_06370	COG0542	response to heat
IM538_06380	COG3949	Membrane
IM538_06395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IM538_06400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IM538_06405	COG2223	nitrite transmembrane transporter activity
IM538_06415	COG3383	formate dehydrogenase (NAD+) activity
IM538_06430	COG2962	Rard protein
IM538_06435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IM538_06440	COG4873	Protein conserved in bacteria
IM538_06445	COG4667	esterase of the alpha-beta hydrolase superfamily
IM538_06460	COG3773	Cell wall hydrolase
IM538_06470	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_06485	COG0488	(ABC) transporter
IM538_06500	COG0523	cobalamin synthesis protein
IM538_06510	COG0569	domain protein
IM538_06525	COG1253	flavin adenine dinucleotide binding
IM538_06540	COG0673	inositol 2-dehydrogenase activity
IM538_06550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IM538_06560	COG0488	(ABC) transporter
IM538_06580	COG3850	Histidine kinase
IM538_06580	COG5002	protein histidine kinase activity
IM538_06595	COG2309	aminopeptidase activity
IM538_06610	COG1725	Transcriptional regulator
IM538_06615	COG1131	(ABC) transporter
IM538_06625	COG1136	(ABC) transporter
IM538_06630	COG0577	efflux transmembrane transporter activity
IM538_06640	COG0840	transmembrane signaling receptor activity
IM538_06645	COG2814	Major facilitator Superfamily
IM538_06675	COG2814	Major facilitator Superfamily
IM538_06705	COG4533	DNA binding
IM538_06720	COG0697	spore germination
IM538_06750	COG2197	response regulator
IM538_06755	COG4585	Histidine kinase
IM538_06760	COG0842	Transport permease protein
IM538_06765	COG1131	(ABC) transporter
IM538_06780	COG1595	DNA-templated transcription, initiation
IM538_06800	COG0531	amino acid
IM538_06805	COG0697	spore germination
IM538_06820	COG0726	polysaccharide deacetylase
IM538_06860	COG0515	serine threonine protein kinase
IM538_06885	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM538_06890	COG4605	iron ion homeostasis
IM538_06895	COG4604	ABC transporter, ATP-binding protein
IM538_06900	COG4607	ABC-type enterochelin transport system periplasmic component
IM538_06905	COG2329	Antibiotic biosynthesis monooxygenase
IM538_06910	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IM538_06920	COG3152	Membrane
IM538_06935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM538_06940	COG2323	membrane
IM538_06950	COG2323	membrane
IM538_06960	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IM538_06975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM538_06980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM538_06985	COG0716	FMN binding
IM538_07005	COG0789	Transcriptional regulator
IM538_07010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IM538_07015	COG1472	Belongs to the glycosyl hydrolase 3 family
IM538_07020	COG2031	fatty acid transporter
IM538_07025	COG0598	Magnesium transport protein CorA
IM538_07045	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM538_07050	COG2814	Major facilitator Superfamily
IM538_07075	COG0346	lactoylglutathione lyase activity
IM538_07085	COG0671	phosphoesterase, PA-phosphatase related
IM538_07090	COG0438	transferase activity, transferring glycosyl groups
IM538_07090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM538_07095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IM538_07115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IM538_07145	COG0523	cobalamin synthesis protein
IM538_07150	COG0444	Belongs to the ABC transporter superfamily
IM538_07155	COG4608	Belongs to the ABC transporter superfamily
IM538_07165	COG0601	transmembrane transport
IM538_07170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_07190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IM538_07195	COG1278	Cold shock
IM538_07200	COG2076	Multidrug Resistance protein
IM538_07205	COG2076	Multidrug Resistance protein
IM538_07210	COG2197	response regulator
IM538_07215	COG4585	Histidine kinase
IM538_07230	COG4989	oxidoreductase activity
IM538_07235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IM538_07245	COG0789	Transcriptional regulator
IM538_07250	COG0004	ammonium transporteR
IM538_07275	COG2211	Major facilitator Superfamily
IM538_07280	COG0367	asparagine synthase
IM538_07300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IM538_07305	COG4807	Protein conserved in bacteria
IM538_07310	COG4589	Belongs to the CDS family
IM538_07320	COG0840	transmembrane signaling receptor activity
IM538_07360	COG2340	Cysteine-rich secretory protein family
IM538_07395	COG1131	(ABC) transporter
IM538_07405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IM538_07415	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IM538_07435	COG3264	Mechanosensitive ion channel
IM538_07435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IM538_07470	COG0778	Nitroreductase
IM538_07505	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IM538_07510	COG1061	Type III restriction enzyme res subunit
IM538_07520	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IM538_07550	COG1061	Type III restriction enzyme res subunit
IM538_07565	COG0720	synthase
IM538_07585	COG2322	membrane
IM538_07595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IM538_07600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IM538_07615	COG0640	Transcriptional regulator
IM538_07625	COG2226	methyltransferase
IM538_07645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IM538_07645	COG2111	Na H antiporter
IM538_07650	COG0651	ATP synthesis coupled electron transport
IM538_07655	COG1006	Multisubunit Na H antiporter MnhC subunit
IM538_07660	COG2111	Na H antiporter
IM538_07670	COG1320	monovalent cation:proton antiporter activity
IM538_07675	COG2212	antiporter activity
IM538_07690	COG0640	Transcriptional regulator
IM538_07695	COG0346	lactoylglutathione lyase activity
IM538_07740	COG2116	formate transmembrane transporter activity
IM538_07780	COG1725	Transcriptional regulator
IM538_07785	COG1131	(ABC) transporter
IM538_07800	COG1595	DNA-templated transcription, initiation
IM538_07810	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IM538_07825	COG1823	symporter activity
IM538_07855	COG1136	(ABC) transporter
IM538_07870	COG0745	RESPONSE REGULATOR receiver
IM538_07875	COG2814	Major facilitator Superfamily
IM538_07895	COG0572	uridine kinase
IM538_07925	COG4191	Histidine kinase
IM538_07930	COG1744	ABC transporter substrate-binding protein PnrA-like
IM538_07935	COG0840	transmembrane signaling receptor activity
IM538_07950	COG0492	ferredoxin-NADP+ reductase activity
IM538_07955	COG1120	ATPase activity
IM538_07960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IM538_07965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM538_07970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM538_07980	COG3655	Transcriptional regulator
IM538_08005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM538_08010	COG0596	Alpha beta hydrolase
IM538_08075	COG5001	Diguanylate cyclase
IM538_08075	COG3706	GGDEF domain
IM538_08075	COG4251	negative regulation of phosphorylation
IM538_08075	COG2203	Gaf domain
IM538_08090	COG2814	Major facilitator Superfamily
IM538_08235	COG3546	catalase activity
IM538_08250	COG1247	-acetyltransferase
IM538_08260	COG0791	NLP P60 protein
IM538_08260	COG1388	LysM domain
IM538_08270	COG3706	GGDEF domain
IM538_08280	COG2816	NAD+ diphosphatase activity
IM538_08315	COG0745	RESPONSE REGULATOR receiver
IM538_08320	COG0642	Histidine kinase
IM538_08340	COG3706	GGDEF domain
IM538_08365	COG2323	membrane
IM538_08370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IM538_08385	COG0456	acetyltransferase
IM538_08385	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IM538_08395	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IM538_08425	COG1131	(ABC) transporter
IM538_08450	COG0701	Predicted permease
IM538_08455	COG3689	TIGRFAM TIGR03943 family protein
IM538_08465	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IM538_08495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IM538_08520	COG0456	acetyltransferase
IM538_08525	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_08565	COG0702	epimerase
IM538_08575	COG4149	molybdate abc transporter
IM538_08580	COG0725	ABC transporter, periplasmic molybdate-binding protein
IM538_08625	COG3279	Response regulator of the LytR AlgR family
IM538_08660	COG0569	domain protein
IM538_08665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IM538_08670	COG0489	protein tyrosine kinase activity
IM538_08680	COG2318	DinB family
IM538_08685	COG2207	Transcriptional regulator
IM538_08685	COG3708	Transcriptional regulator
IM538_08690	COG0697	spore germination
IM538_08710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IM538_08730	COG0167	dihydroorotate dehydrogenase activity
IM538_08740	COG0154	amidase activity
IM538_08745	COG1609	Transcriptional regulator
IM538_08760	COG3852	Histidine kinase
IM538_08780	COG2135	peptidase activity
IM538_08785	COG1846	Transcriptional regulator
IM538_08790	COG5001	Diguanylate cyclase
IM538_08790	COG3300	MHYT domain
IM538_08795	COG1187	pseudouridine synthase activity
IM538_08825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM538_08840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IM538_08850	COG1126	abc transporter atp-binding protein
IM538_08855	COG0765	amino acid transport
IM538_08860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM538_08865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IM538_08915	COG3852	Histidine kinase
IM538_08920	COG0384	phenazine biosynthesis protein PhzF
IM538_08930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IM538_08945	COG0640	Transcriptional regulator
IM538_08955	COG2318	DinB family
IM538_08965	COG1595	DNA-templated transcription, initiation
IM538_08990	COG1733	regulation of RNA biosynthetic process
IM538_08995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM538_08995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM538_09020	COG1231	oxidoreductase activity
IM538_09025	COG0628	permease
IM538_09030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IM538_09050	COG1403	HNH endonuclease
IM538_09070	COG2816	NAD+ diphosphatase activity
IM538_09075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IM538_09080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IM538_09110	COG0735	belongs to the Fur family
IM538_09120	COG0385	Bile acid
IM538_09130	COG1129	ABC transporter
IM538_09135	COG1172	Belongs to the binding-protein-dependent transport system permease family
IM538_09145	COG3832	glyoxalase III activity
IM538_09155	COG1253	flavin adenine dinucleotide binding
IM538_09180	COG1227	inorganic diphosphatase activity
IM538_09185	COG0494	nUDIX hydrolase
IM538_09270	COG2112	serine threonine protein kinase
IM538_09275	COG2323	membrane
IM538_09280	COG2720	vancomycin resistance protein
IM538_09330	COG3481	metal-dependent phosphohydrolase, HD sub domain
IM538_09365	COG1072	(Pantothenic acid kinase))
IM538_09405	COG0697	spore germination
IM538_09420	COG2378	regulation of single-species biofilm formation
IM538_09435	COG5002	protein histidine kinase activity
IM538_09450	COG1823	symporter activity
IM538_09455	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IM538_09455	COG0392	lysyltransferase activity
IM538_09465	COG3852	Histidine kinase
IM538_09470	COG3180	Ammonia monooxygenase
IM538_09475	COG0697	spore germination
IM538_09480	COG0697	spore germination
IM538_09485	COG0514	ATP-dependent DNA helicase (RecQ)
IM538_09490	COG0584	glycerophosphoryl diester phosphodiesterase
IM538_09495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IM538_09500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IM538_09505	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IM538_09515	COG1793	dna ligase
IM538_09520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IM538_09525	COG2267	carboxylic ester hydrolase activity
IM538_09530	COG1363	Peptidase, m42
IM538_09550	COG5001	Diguanylate cyclase
IM538_09550	COG4251	negative regulation of phosphorylation
IM538_09550	COG3706	GGDEF domain
IM538_09550	COG2203	Gaf domain
IM538_09560	COG4191	Histidine kinase
IM538_09565	COG0714	Associated with various cellular activities
IM538_09580	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_09590	COG0596	Alpha beta hydrolase
IM538_09600	COG3711	transcriptional antiterminator
IM538_09610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IM538_09615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM538_09635	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_09650	COG2084	Dehydrogenase
IM538_09665	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_09670	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_09675	COG0318	PFAM AMP-dependent synthetase and ligase
IM538_09700	COG1960	acyl-CoA dehydrogenase activity
IM538_09715	COG0657	acetylesterase activity
IM538_09720	COG4191	Histidine kinase
IM538_09725	COG0436	Aminotransferase
IM538_09740	COG5582	Belongs to the UPF0302 family
IM538_09750	COG0346	lactoylglutathione lyase activity
IM538_09760	COG2205	protein histidine kinase activity
IM538_09775	COG0784	Response regulator, receiver
IM538_09775	COG0835	chemotaxis
IM538_09800	COG0745	RESPONSE REGULATOR receiver
IM538_09805	COG5002	protein histidine kinase activity
IM538_09815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IM538_09820	COG5001	Diguanylate cyclase
IM538_09820	COG3300	MHYT domain
IM538_09825	COG1408	metallophosphoesterase
IM538_09830	COG4191	Histidine kinase
IM538_09835	COG2172	sigma factor antagonist activity
IM538_09840	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_09845	COG2200	EAL domain
IM538_09860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IM538_09860	COG0426	domain, Protein
IM538_09865	COG4703	Protein of unknown function (DUF1797)
IM538_09870	COG5506	Protein of unknown function (DUF1694)
IM538_09880	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
IM538_09890	COG0517	IMP dehydrogenase activity
IM538_09895	COG0477	Major facilitator Superfamily
IM538_09910	COG0583	DNA-binding transcription factor activity
IM538_09915	COG2171	N-acyltransferase activity
IM538_09920	COG1473	amidohydrolase
IM538_09930	COG0668	transmembrane transport
IM538_09935	COG0450	alkyl hydroperoxide reductase
IM538_09940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM538_09945	COG1132	(ABC) transporter
IM538_09950	COG1132	(ABC) transporter
IM538_09960	COG0569	domain protein
IM538_09965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IM538_09970	COG5503	Protein of unknown function (DUF1447)
IM538_09975	COG0561	phosphatase activity
IM538_09980	COG0242	peptide deformylase activity
IM538_09985	COG0497	DNA recombination
IM538_09995	COG0022	dehydrogenase e1 component
IM538_10040	COG1982	Orn Lys Arg decarboxylase major
IM538_10055	COG4493	Belongs to the UPF0637 family
IM538_10065	COG0483	inositol monophosphate 1-phosphatase activity
IM538_10080	COG1217	gtp-binding protein TYPA
IM538_10095	COG4896	Protein conserved in bacteria
IM538_10110	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IM538_10115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IM538_10120	COG4838	Belongs to the UPF0358 family
IM538_10125	COG0772	Belongs to the SEDS family
IM538_10130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IM538_10135	COG1612	heme a metabolic process
IM538_10140	COG0109	protoheme IX farnesyltransferase activity
IM538_10150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM538_10165	COG3336	cytochrome c oxidase
IM538_10180	COG0628	permease
IM538_10195	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IM538_10200	COG2340	Cysteine-rich secretory protein family
IM538_10230	COG3679	Belongs to the UPF0342 family
IM538_10235	COG4471	UPF0298 protein
IM538_10245	COG0742	ribosomal rna small subunit methyltransferase
IM538_10250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IM538_10255	COG3314	Sporulation integral membrane protein YlbJ
IM538_10260	COG1752	Esterase of the alpha-beta hydrolase superfamily
IM538_10265	COG3480	Lon protease (S16) C-terminal proteolytic domain
IM538_10270	COG1323	Belongs to the UPF0348 family
IM538_10275	COG1399	metal-binding, possibly nucleic acid-binding protein
IM538_10280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IM538_10285	COG1024	Enoyl-CoA hydratase
IM538_10295	COG0454	-acetyltransferase
IM538_10300	COG0439	Biotin carboxylase
IM538_10305	COG0511	ligase activity, forming carbon-carbon bonds
IM538_10310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IM538_10315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IM538_10325	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IM538_10330	COG2001	Belongs to the MraZ family
IM538_10335	COG0275	rRNA processing
IM538_10340	COG4839	cell division protein FtsL
IM538_10345	COG0768	penicillin binding
IM538_10350	COG0768	penicillin binding
IM538_10355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IM538_10365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM538_10370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IM538_10375	COG0772	Belongs to the SEDS family
IM538_10385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IM538_10390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IM538_10395	COG3879	Bacterial protein of unknown function (DUF881)
IM538_10400	COG3879	Bacterial protein of unknown function (DUF881)
IM538_10405	COG3856	small basic protein
IM538_10410	COG0849	cell division
IM538_10415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IM538_10425	COG1191	sigma factor activity
IM538_10430	COG1191	sigma factor activity
IM538_10435	COG1873	PFAM PRC-barrel domain
IM538_10445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IM538_10450	COG1799	cell septum assembly
IM538_10455	COG0762	integral membrane protein
IM538_10460	COG2302	S4 RNA-binding domain
IM538_10465	COG3599	regulation of cell shape
IM538_10470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IM538_10475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IM538_10480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IM538_10485	COG0564	pseudouridine synthase activity
IM538_10490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IM538_10505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IM538_10515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IM538_10520	COG0543	2 iron, 2 sulfur cluster binding
IM538_10525	COG0167	dihydroorotate dehydrogenase activity
IM538_10530	COG0284	orotidine-5'-phosphate decarboxylase activity
IM538_10535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IM538_10545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IM538_10550	COG1561	YicC-like family, N-terminal region
IM538_10555	COG2052	Domain of unknown function (DUF370)
IM538_10560	COG0194	GDP metabolic process
IM538_10565	COG1758	RNA polymerase activity
IM538_10570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IM538_10575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IM538_10585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IM538_10590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IM538_10590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IM538_10595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IM538_10600	COG0631	protein serine/threonine phosphatase activity
IM538_10605	COG2815	serine threonine protein kinase
IM538_10605	COG0515	serine threonine protein kinase
IM538_10610	COG1162	GTPase activity
IM538_10615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IM538_10630	COG1302	Protein conserved in bacteria
IM538_10635	COG1461	Dihydroxyacetone kinase
IM538_10640	COG1760	l-serine dehydratase
IM538_10645	COG1760	l-serine dehydratase
IM538_10650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IM538_10655	COG1349	DNA-binding transcription factor activity
IM538_10660	COG0416	fatty acid biosynthetic process
IM538_10665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IM538_10670	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_10675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IM538_10680	COG0571	ribonuclease III activity
IM538_10685	COG1196	nuclear chromosome segregation
IM538_10690	COG0552	protein localization to endoplasmic reticulum
IM538_10700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IM538_10710	COG1837	Belongs to the UPF0109 family
IM538_10720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IM538_10730	COG0335	large ribosomal subunit rRNA binding
IM538_10745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IM538_10755	COG2257	FlhB HrpN YscU SpaS Family
IM538_10765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IM538_10770	COG0758	DNA mediated transformation
IM538_10775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IM538_10780	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IM538_10790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IM538_10795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IM538_10800	COG1815	bacterial-type flagellum-dependent cell motility
IM538_10805	COG1558	bacterial-type flagellum-dependent cell motility
IM538_10810	COG1677	Flagellar hook-basal body complex protein FliE
IM538_10815	COG1766	The M ring may be actively involved in energy transduction
IM538_10820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IM538_10825	COG1317	bacterial-type flagellum organization
IM538_10830	COG1157	protein secretion by the type III secretion system
IM538_10835	COG2882	bacterial-type flagellum organization
IM538_10850	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IM538_10860	COG4786	Flagellar basal body rod
IM538_10865	COG1582	Flagellar protein (FlbD)
IM538_10875	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IM538_10880	COG1776	CheC inhibitor of MCP methylation
IM538_10880	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IM538_10885	COG2201	protein-glutamate methylesterase activity
IM538_10890	COG3190	flagellar
IM538_10895	COG1338	Plays a role in the flagellum-specific transport system
IM538_10900	COG1987	bacterial-type flagellum assembly
IM538_10905	COG1684	flagellar biosynthetic protein fliR
IM538_10910	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IM538_10915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IM538_10920	COG1419	protein localization to endoplasmic reticulum
IM538_10925	COG0455	bacterial-type flagellum organization
IM538_10930	COG2201	protein-glutamate methylesterase activity
IM538_10935	COG2198	Histidine kinase
IM538_10935	COG0643	Histidine kinase
IM538_10940	COG0835	chemotaxis
IM538_10945	COG1776	CheC inhibitor of MCP methylation
IM538_10950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IM538_10955	COG1191	sigma factor activity
IM538_10975	COG0052	Belongs to the universal ribosomal protein uS2 family
IM538_10980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IM538_10990	COG0233	cytoplasmic translational termination
IM538_10995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IM538_11000	COG4589	Belongs to the CDS family
IM538_11005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IM538_11010	COG0750	zinc metalloprotease
IM538_11015	COG0442	prolyl-tRNA aminoacylation
IM538_11020	COG2176	DNA-directed DNA polymerase activity
IM538_11025	COG0779	Required for maturation of 30S ribosomal subunits
IM538_11030	COG0195	Participates in both transcription termination and antitermination
IM538_11035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IM538_11040	COG1358	cellular component organization or biogenesis
IM538_11045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IM538_11050	COG1550	Protein conserved in bacteria
IM538_11055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IM538_11060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IM538_11065	COG0196	riboflavin kinase activity
IM538_11075	COG1185	polyribonucleotide nucleotidyltransferase activity
IM538_11080	COG0726	polysaccharide deacetylase
IM538_11085	COG0612	Peptidase, M16
IM538_11090	COG1873	PFAM PRC-barrel domain
IM538_11095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IM538_11100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IM538_11105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IM538_11110	COG0527	aspartate kinase activity
IM538_11120	COG0740	serine-type endopeptidase activity
IM538_11130	COG1674	ftsk spoiiie
IM538_11130	COG4980	gas vesicle protein
IM538_11135	COG2188	Transcriptional regulator
IM538_11140	COG1744	ABC transporter substrate-binding protein PnrA-like
IM538_11145	COG3845	ABC transporter
IM538_11150	COG4603	Belongs to the binding-protein-dependent transport system permease family
IM538_11155	COG1079	Belongs to the binding-protein-dependent transport system permease family
IM538_11160	COG0612	Peptidase, M16
IM538_11165	COG0612	Peptidase, M16
IM538_11170	COG0300	oxidoreductase activity
IM538_11185	COG1426	Protein conserved in bacteria
IM538_11190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IM538_11195	COG1058	Belongs to the CinA family
IM538_11195	COG1546	Belongs to the CinA family
IM538_11200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IM538_11205	COG1418	mRNA catabolic process
IM538_11210	COG1692	metallophosphoesterase
IM538_11215	COG2359	stage V sporulation protein S
IM538_11225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IM538_11225	COG0674	pyruvate-flavodoxin oxidoreductase activity
IM538_11230	COG1013	pyruvate-flavodoxin oxidoreductase activity
IM538_11235	COG1063	alcohol dehydrogenase
IM538_11240	COG0156	8-amino-7-oxononanoate synthase activity
IM538_11250	COG4550	Control of competence regulator ComK, YlbF/YmcA
IM538_11260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IM538_11265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IM538_11280	COG0464	growth
IM538_11285	COG2860	membrane
IM538_11290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IM538_11295	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IM538_11300	COG0789	Transcriptional regulator
IM538_11305	COG0174	glutamine synthetase
IM538_11310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IM538_11320	COG4224	UPF0291 protein
IM538_11335	COG3763	UPF0154 protein
IM538_11340	COG1132	(ABC) transporter
IM538_11345	COG1132	(ABC) transporter
IM538_11355	COG0785	Cytochrome C biogenesis protein
IM538_11360	COG2201	protein-glutamate methylesterase activity
IM538_11365	COG4846	Membrane protein involved in cytochrome C biogenesis
IM538_11375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IM538_11380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IM538_11385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IM538_11395	COG2205	protein histidine kinase activity
IM538_11440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IM538_11450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM538_11470	COG0824	Thioesterase
IM538_11480	COG4841	protein insertion into membrane
IM538_11485	COG2843	Capsule synthesis protein
IM538_11500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IM538_11510	COG2211	Major facilitator Superfamily
IM538_11515	COG3706	GGDEF domain
IM538_11520	COG1832	CoA-binding protein
IM538_11525	COG0187	DNA topoisomerase II activity
IM538_11530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IM538_11540	COG0598	Magnesium transport protein CorA
IM538_11545	COG0084	hydrolase, TatD family'
IM538_11565	COG4974	Belongs to the 'phage' integrase family
IM538_11585	COG2720	vancomycin resistance protein
IM538_11615	COG1280	lysine exporter protein (LysE YggA)
IM538_11620	COG0789	Transcriptional regulator
IM538_11625	COG2200	EAL domain
IM538_11630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IM538_11640	COG2318	DinB family
IM538_11645	COG0432	Pfam Uncharacterised protein family UPF0047
IM538_11660	COG2271	Major facilitator Superfamily
IM538_11665	COG0300	oxidoreductase activity
IM538_11670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM538_11690	COG3639	organic phosphonate transmembrane transporter activity
IM538_11695	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IM538_11700	COG0726	polysaccharide deacetylase
IM538_11705	COG0494	nUDIX hydrolase
IM538_11725	COG1473	amidohydrolase
IM538_11730	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IM538_11730	COG2105	PFAM AIG2 family protein
IM538_11740	COG0194	GDP metabolic process
IM538_11745	COG0861	Integral membrane protein TerC family
IM538_11785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IM538_11790	COG1309	transcriptional regulator
IM538_11795	COG1027	Aspartate ammonia-lyase
IM538_11800	COG1752	Esterase of the alpha-beta hydrolase superfamily
IM538_11810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM538_11815	COG5002	protein histidine kinase activity
IM538_11835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM538_11845	COG2153	protein acetylation
IM538_11850	COG2814	Major facilitator Superfamily
IM538_11855	COG2746	aminoglycoside 3-N-acetyltransferase activity
IM538_11860	COG2814	Major facilitator Superfamily
IM538_11865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IM538_11875	COG1733	regulation of RNA biosynthetic process
IM538_11900	COG1595	DNA-templated transcription, initiation
IM538_11915	COG4912	Dna alkylation repair
IM538_11920	COG3069	C4-dicarboxylate transmembrane transporter activity
IM538_11925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IM538_11930	COG2608	mercury ion transmembrane transporter activity
IM538_11945	COG0444	Belongs to the ABC transporter superfamily
IM538_11950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_11955	COG0601	transmembrane transport
IM538_11960	COG0747	negative chemotaxis
IM538_11965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IM538_11975	COG0534	Mate efflux family protein
IM538_12005	COG4555	ABC transporter
IM538_12050	COG2267	carboxylic ester hydrolase activity
IM538_12065	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IM538_12080	COG1309	transcriptional regulator
IM538_12085	COG0483	inositol monophosphate 1-phosphatase activity
IM538_12100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IM538_12130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IM538_12140	COG0395	ABC-type sugar transport system, permease component
IM538_12160	COG1609	Transcriptional regulator
IM538_12170	COG0697	spore germination
IM538_12185	COG1595	DNA-templated transcription, initiation
IM538_12200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_12215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IM538_12220	COG1012	belongs to the aldehyde dehydrogenase family
IM538_12225	COG2508	Transcriptional regulator
IM538_12250	COG0167	dihydroorotate dehydrogenase activity
IM538_12270	COG0435	Glutathione S-transferase
IM538_12280	COG0673	inositol 2-dehydrogenase activity
IM538_12290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IM538_12300	COG0326	Molecular chaperone. Has ATPase activity
IM538_12335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM538_12350	COG2031	fatty acid transporter
IM538_12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IM538_12365	COG0656	L-ascorbic acid biosynthetic process
IM538_12385	COG0683	leucine binding
IM538_12395	COG0559	Belongs to the binding-protein-dependent transport system permease family
IM538_12400	COG1022	Amp-dependent synthetase and ligase
IM538_12425	COG0708	Exodeoxyribonuclease III
IM538_12430	COG2197	response regulator
IM538_12435	COG4585	Histidine kinase
IM538_12440	COG3239	Fatty acid desaturase
IM538_12450	COG4191	Histidine kinase
IM538_12470	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM538_12475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IM538_12480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IM538_12485	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IM538_12495	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM538_12525	COG4120	Belongs to the binding-protein-dependent transport system permease family
IM538_12535	COG2070	2-Nitropropane dioxygenase
IM538_12540	COG3327	negative regulation of DNA-templated transcription, initiation
IM538_12545	COG0183	Belongs to the thiolase family
IM538_12550	COG1250	3-hydroxyacyl-CoA dehydrogenase
IM538_12555	COG1012	belongs to the aldehyde dehydrogenase family
IM538_12560	COG1024	Enoyl-CoA hydratase
IM538_12565	COG1024	Enoyl-CoA hydratase
IM538_12575	COG2151	metal-sulfur cluster biosynthetic enzyme
IM538_12590	COG3396	Phenylacetate-CoA oxygenase
IM538_12615	COG5609	conserved protein (DUF2294)
IM538_12680	COG2027	D-alanyl-D-alanine carboxypeptidase
IM538_12685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IM538_12700	COG2340	Cysteine-rich secretory protein family
IM538_12705	COG0488	(ABC) transporter
IM538_12745	COG3314	Sporulation integral membrane protein YlbJ
IM538_12750	COG0010	Belongs to the arginase family
IM538_12755	COG1228	amidohydrolase
IM538_12760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IM538_12780	COG3403	YqcI/YcgG family
IM538_12785	COG2720	vancomycin resistance protein
IM538_12790	COG1917	Cupin 2, conserved barrel domain protein
IM538_12790	COG4977	sequence-specific DNA binding
IM538_12795	COG3663	DNA glycosylase
IM538_12800	COG3483	tryptophan 2,3-dioxygenase activity
IM538_12820	COG3739	integral membrane protein
IM538_12825	COG1247	-acetyltransferase
IM538_12835	COG3973	AAA domain
IM538_12840	COG1307	EDD domain protein, DegV family
IM538_12845	COG2385	sporulation resulting in formation of a cellular spore
IM538_12845	COG2247	cell wall binding repeat
IM538_12850	COG0346	lactoylglutathione lyase activity
IM538_12865	COG0456	acetyltransferase
IM538_12870	COG3153	acetyltransferase
IM538_12870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IM538_12880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IM538_12885	COG5002	protein histidine kinase activity
IM538_12955	COG1132	(ABC) transporter
IM538_12960	COG1132	(ABC) transporter
IM538_12965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IM538_13010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IM538_13055	COG3695	enzyme binding
IM538_13090	COG2312	Erythromycin esterase
IM538_13120	COG2814	Major facilitator Superfamily
IM538_13135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IM538_13185	COG1695	Transcriptional regulator
IM538_13190	COG0772	Belongs to the SEDS family
IM538_13245	COG0693	protein deglycase activity
IM538_13270	COG0402	S-adenosylhomocysteine deaminase activity
IM538_13275	COG1280	lysine exporter protein (LysE YggA)
IM538_13280	COG1335	isochorismatase
IM538_13285	COG0583	DNA-binding transcription factor activity
IM538_13290	COG0640	Transcriptional regulator
IM538_13365	COG5002	protein histidine kinase activity
IM538_13415	COG0662	Cupin 2, conserved barrel domain protein
IM538_13430	COG4555	ABC transporter
IM538_13575	COG1714	RDD family
IM538_13630	COG1233	COG1233 Phytoene dehydrogenase and related
IM538_13655	COG1304	FMN binding
IM538_13660	COG1562	ergosterol biosynthetic process
IM538_13865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IM538_13895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IM538_13900	COG0640	Transcriptional regulator
IM538_13930	COG1363	Peptidase, m42
IM538_13985	COG1011	Hydrolase
IM538_14000	COG2176	DNA-directed DNA polymerase activity
IM538_14010	COG2340	Cysteine-rich secretory protein family
IM538_14090	COG2816	NAD+ diphosphatase activity
IM538_14110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IM538_14115	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IM538_14120	COG1131	(ABC) transporter
IM538_14125	COG0456	acetyltransferase
IM538_14125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IM538_14130	COG0371	Dehydrogenase
IM538_14150	COG0577	efflux transmembrane transporter activity
IM538_14150	COG1136	(ABC) transporter
IM538_14155	COG1595	DNA-templated transcription, initiation
IM538_14165	COG3773	Cell wall hydrolase
IM538_14185	COG1505	serine-type exopeptidase activity
IM538_14190	COG2223	nitrite transmembrane transporter activity
IM538_14250	COG3858	chitin binding
IM538_14270	COG0436	Aminotransferase
IM538_14280	COG1193	negative regulation of DNA recombination
IM538_14310	COG0028	Belongs to the TPP enzyme family
IM538_14325	COG1309	transcriptional regulator
IM538_14330	COG2814	Major facilitator Superfamily
IM538_14345	COG2814	Major facilitator Superfamily
IM538_14350	COG4548	von Willebrand factor, type A
IM538_14355	COG0714	Associated with various cellular activities
IM538_14360	COG2404	hydrolase activity, acting on ester bonds
IM538_14370	COG1164	Oligoendopeptidase f
IM538_14390	COG0534	Mate efflux family protein
IM538_14395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IM538_14410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM538_14425	COG0398	Pfam SNARE associated Golgi protein
IM538_14450	COG0861	Integral membrane protein TerC family
IM538_14460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IM538_14480	COG5577	PFAM Coat F domain
IM538_14485	COG2217	Heavy metal translocating P-type atpase
IM538_14515	COG0437	4 iron, 4 sulfur cluster binding
IM538_14520	COG0243	molybdopterin cofactor binding
IM538_14535	COG1876	peptidase activity
IM538_14560	COG4326	sporulation control protein
IM538_14580	COG4479	Belongs to the UPF0346 family
IM538_14590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IM538_14605	COG3773	Cell wall hydrolase
IM538_14610	COG0473	3-isopropylmalate dehydrogenase activity
IM538_14615	COG2113	Glycine betaine
IM538_14620	COG4176	ABC-type proline glycine betaine transport system permease component
IM538_14625	COG0517	IMP dehydrogenase activity
IM538_14625	COG4175	Glycine betaine
IM538_14630	COG1510	regulation of RNA biosynthetic process
IM538_14650	COG1660	Displays ATPase and GTPase activities
IM538_14655	COG2169	Transcriptional regulator
IM538_14655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IM538_14665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IM538_14670	COG1131	(ABC) transporter
IM538_14685	COG0745	RESPONSE REGULATOR receiver
IM538_14690	COG5002	protein histidine kinase activity
IM538_14695	COG1136	(ABC) transporter
IM538_14700	COG0577	efflux transmembrane transporter activity
IM538_14725	COG0789	Transcriptional regulator
IM538_14765	COG1509	lysine 2,3-aminomutase activity
IM538_14840	COG1509	lysine 2,3-aminomutase activity
IM538_14845	COG3829	transcription factor binding
IM538_14850	COG0456	acetyltransferase
IM538_14855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM538_14860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IM538_14865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IM538_14870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IM538_14875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IM538_14890	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IM538_14900	COG1279	arginine transmembrane transporter activity
IM538_14920	COG1473	amidohydrolase
IM538_14930	COG1012	belongs to the aldehyde dehydrogenase family
IM538_14940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IM538_14940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IM538_14945	COG0584	glycerophosphoryl diester phosphodiesterase
IM538_14995	COG2755	lipolytic protein G-D-S-L family
IM538_15000	COG1408	metallophosphoesterase
IM538_15005	COG0726	polysaccharide deacetylase
IM538_15010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM538_15020	COG1999	signal sequence binding
IM538_15025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IM538_15030	COG0529	Catalyzes the synthesis of activated sulfate
IM538_15035	COG2046	Belongs to the sulfate adenylyltransferase family
IM538_15040	COG0175	sulfate reduction
IM538_15050	COG1809	phosphosulfolactate synthase activity
IM538_15055	COG2814	Major facilitator Superfamily
IM538_15065	COG5002	protein histidine kinase activity
IM538_15090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IM538_15095	COG1272	protein, Hemolysin III
IM538_15100	COG0204	Acyl-transferase
IM538_15105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IM538_15110	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IM538_15120	COG0861	Integral membrane protein TerC family
IM538_15135	COG2521	methyltransferase
IM538_15135	COG2136	Putative SAM-dependent methyltransferase
IM538_15145	COG0726	polysaccharide deacetylase
IM538_15150	COG1413	lyase activity
IM538_15155	COG1388	LysM domain
IM538_15155	COG0791	NLP P60 protein
IM538_15160	COG0488	(ABC) transporter
IM538_15165	COG1418	mRNA catabolic process
IM538_15180	COG1307	EDD domain protein, DegV family
IM538_15200	COG1525	nuclease
IM538_15210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IM538_15220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IM538_15220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IM538_15220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IM538_15225	COG1105	Belongs to the carbohydrate kinase PfkB family
IM538_15230	COG1349	DNA-binding transcription factor activity
IM538_15235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IM538_15265	COG0328	RNA-DNA hybrid ribonuclease activity
IM538_15290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IM538_15310	COG3541	Predicted nucleotidyltransferase
IM538_15315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IM538_15320	COG1755	Isoprenylcysteine carboxyl methyltransferase
IM538_15325	COG3424	synthase
IM538_15355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IM538_15360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM538_15365	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IM538_15370	COG1199	ATP-dependent helicase activity
IM538_15380	COG0116	Belongs to the methyltransferase superfamily
IM538_15405	COG3359	exonuclease
IM538_15410	COG1205	dead DEAH box helicase
IM538_15410	COG1111	helicase
IM538_15415	COG3011	Protein conserved in bacteria
IM538_15425	COG0583	DNA-binding transcription factor activity
IM538_15435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IM538_15450	COG4608	Belongs to the ABC transporter superfamily
IM538_15455	COG0444	Belongs to the ABC transporter superfamily
IM538_15460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM538_15465	COG0601	transmembrane transport
IM538_15470	COG4166	transmembrane transport
IM538_15480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IM538_15545	COG3331	DNA recombination
IM538_15550	COG4499	WXG100 protein secretion system (Wss), protein YukC
IM538_15550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM538_15565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IM538_15570	COG3935	DnaD domain protein
IM538_15575	COG0436	Aminotransferase
IM538_15595	COG1199	ATP-dependent helicase activity
IM538_15595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IM538_15600	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IM538_15605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IM538_15620	COG0617	tRNA 3'-terminal CCA addition
IM538_15625	COG0438	transferase activity, transferring glycosyl groups
IM538_15635	COG1803	Methylglyoxal synthase
IM538_15640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IM538_15645	COG1694	Mazg nucleotide pyrophosphohydrolase
IM538_15650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IM538_15655	COG2738	Putative neutral zinc metallopeptidase
IM538_15665	COG4347	Protein of unknown function (DUF1405)
IM538_15675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IM538_15695	COG0457	Tetratricopeptide repeat
IM538_15705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IM538_15710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IM538_15715	COG0159	tryptophan synthase activity
IM538_15725	COG0135	phosphoribosylanthranilate isomerase activity
IM538_15735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IM538_15745	COG4401	Chorismate mutase type I
IM538_15750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IM538_15755	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IM538_15760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IM538_15765	COG0105	UTP biosynthetic process
IM538_15770	COG0142	geranyltranstransferase activity
IM538_15775	COG2226	methyltransferase
IM538_15780	COG0142	geranyltranstransferase activity
IM538_15790	COG0302	gtp cyclohydrolase
IM538_15795	COG0776	regulation of translation
IM538_15800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IM538_15820	COG1160	GTP binding
IM538_15845	COG1304	FMN binding
IM538_15850	COG0539	negative regulation of cytoplasmic translation
IM538_15860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IM538_15870	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IM538_15875	COG2959	enzyme of heme biosynthesis
IM538_15880	COG3773	Cell wall hydrolase
IM538_15880	COG3409	Peptidoglycan-binding domain 1 protein
IM538_15885	COG2339	peptidase activity
IM538_15895	COG0492	ferredoxin-NADP+ reductase activity
IM538_15900	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IM538_15905	COG4862	establishment of competence for transformation
IM538_15910	COG1408	metallophosphoesterase
IM538_15930	COG3546	catalase activity
IM538_15935	COG1388	LysM domain
IM538_15940	COG1266	CAAX protease self-immunity
IM538_15945	COG0514	ATP-dependent DNA helicase (RecQ)
IM538_15960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IM538_15965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IM538_15970	COG1196	nuclear chromosome segregation
IM538_15970	COG0741	lytic transglycosylase activity
IM538_15970	COG0739	heme binding
IM538_15980	COG1595	DNA-templated transcription, initiation
IM538_15985	COG5002	protein histidine kinase activity
IM538_15990	COG0745	RESPONSE REGULATOR receiver
IM538_15995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IM538_16000	COG1333	cytochrome c biogenesis protein
IM538_16005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM538_16010	COG1187	pseudouridine synthase activity
IM538_16015	COG0700	Nucleoside recognition
IM538_16020	COG2715	membrane protein required for spore maturation
IM538_16025	COG1686	Belongs to the peptidase S11 family
IM538_16030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IM538_16050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IM538_16055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IM538_16065	COG1547	Domain of unknown function (DUF309)
IM538_16075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IM538_16080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM538_16080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM538_16085	COG0307	riboflavin synthase, alpha
IM538_16090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM538_16090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM538_16095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IM538_16100	COG4086	secreted protein
IM538_16105	COG0019	diaminopimelate decarboxylase activity
IM538_16110	COG0697	spore germination
IM538_16125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IM538_16150	COG2172	sigma factor antagonist activity
IM538_16160	COG1686	Belongs to the peptidase S11 family
IM538_16180	COG4974	Belongs to the 'phage' integrase family
IM538_16190	COG0735	belongs to the Fur family
IM538_16195	COG1300	Membrane
IM538_16205	COG1379	DNA repair
IM538_16210	COG0494	nUDIX hydrolase
IM538_16220	COG0667	Aldo Keto reductase
IM538_16225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IM538_16225	COG0456	acetyltransferase
IM538_16235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IM538_16240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IM538_16250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IM538_16255	COG1073	alpha beta
IM538_16280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IM538_16295	COG1595	DNA-templated transcription, initiation
IM538_16300	COG0300	oxidoreductase activity
IM538_16305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM538_16310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IM538_16315	COG1215	transferase activity, transferring glycosyl groups
IM538_16320	COG1902	pentaerythritol trinitrate reductase activity
IM538_16335	COG0778	Nitroreductase
IM538_16350	COG1234	tRNA 3'-trailer cleavage
IM538_16370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IM538_16375	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IM538_16380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IM538_16385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IM538_16390	COG0835	chemotaxis
IM538_16395	COG2195	Cleaves the N-terminal amino acid of tripeptides
IM538_16400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IM538_16405	COG0346	lactoylglutathione lyase activity
IM538_16415	COG1376	ErfK ybiS ycfS ynhG family protein
IM538_16420	COG4129	membrane
IM538_16430	COG1703	isobutyryl-CoA mutase activity
IM538_16435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM538_16435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM538_16440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM538_16440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM538_16450	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM538_16455	COG0022	dehydrogenase e1 component
IM538_16460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IM538_16465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IM538_16475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IM538_16480	COG0280	phosphate acetyltransferase
IM538_16485	COG3829	transcription factor binding
IM538_16485	COG3290	protein histidine kinase activity
IM538_16495	COG0584	glycerophosphoryl diester phosphodiesterase
IM538_16500	COG3093	addiction module antidote protein HigA
IM538_16510	COG0750	zinc metalloprotease
IM538_16515	COG0497	DNA recombination
IM538_16525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IM538_16530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IM538_16540	COG1722	exodeoxyribonuclease VII activity
IM538_16545	COG1570	exodeoxyribonuclease VII activity
IM538_16555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IM538_16560	COG1302	Protein conserved in bacteria
IM538_16565	COG0439	Biotin carboxylase
IM538_16570	COG0511	ligase activity, forming carbon-carbon bonds
IM538_16575	COG0840	transmembrane signaling receptor activity
IM538_16615	COG3854	ATPases associated with a variety of cellular activities
IM538_16625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IM538_16630	COG0006	proline dipeptidase activity
IM538_16635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IM538_16650	COG1752	Esterase of the alpha-beta hydrolase superfamily
IM538_16655	COG1321	iron dependent repressor
IM538_16665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM538_16670	COG0095	Lipoate-protein ligase
IM538_16675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM538_16680	COG4974	Belongs to the 'phage' integrase family
IM538_16750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IM538_16755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IM538_16760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IM538_16800	COG1132	(ABC) transporter
IM538_16835	COG1132	(ABC) transporter
IM538_16860	COG1215	transferase activity, transferring glycosyl groups
IM538_16865	COG0438	transferase activity, transferring glycosyl groups
IM538_16870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IM538_16895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IM538_16910	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IM538_16915	COG0517	IMP dehydrogenase activity
IM538_16915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IM538_16920	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IM538_16935	COG0438	transferase activity, transferring glycosyl groups
IM538_16940	COG1216	Glycosyl transferase, family 2
IM538_16945	COG1132	(ABC) transporter
IM538_16955	COG0110	maltose O-acetyltransferase activity
IM538_16965	COG1396	sequence-specific DNA binding
IM538_16970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IM538_16975	COG0110	maltose O-acetyltransferase activity
IM538_16980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IM538_16990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IM538_17000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IM538_17005	COG1086	Polysaccharide biosynthesis protein
IM538_17015	COG1396	sequence-specific DNA binding
IM538_17020	COG1396	sequence-specific DNA binding
IM538_17070	COG4970	Tfp pilus assembly protein FimT
IM538_17075	COG4537	Required for transformation and DNA binding
IM538_17080	COG1459	type II secretion system
IM538_17085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IM538_17090	COG0840	transmembrane signaling receptor activity
IM538_17095	COG2323	membrane
IM538_17120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM538_17135	COG0011	TIGRFAM Protein of
IM538_17150	COG1368	sulfuric ester hydrolase activity
IM538_17155	COG1940	carbohydrate kinase activity
IM538_17165	COG0697	spore germination
IM538_17170	COG0705	Rhomboid family
IM538_17170	COG0457	Tetratricopeptide repeat
IM538_17175	COG1011	Hydrolase
IM538_17190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IM538_17200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IM538_17205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IM538_17210	COG0438	transferase activity, transferring glycosyl groups
IM538_17220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IM538_17225	COG0704	Plays a role in the regulation of phosphate uptake
IM538_17230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IM538_17235	COG0573	inorganic phosphate transmembrane transporter activity
IM538_17240	COG0573	inorganic phosphate transmembrane transporter activity
IM538_17245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IM538_17250	COG0768	penicillin binding
IM538_17255	COG0477	Major facilitator Superfamily
IM538_17265	COG2839	Protein conserved in bacteria
IM538_17270	COG1283	sodium-dependent phosphate transmembrane transporter activity
IM538_17275	COG5521	maltodextrose utilization protein MalA
IM538_17285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IM538_17295	COG4709	membrane
IM538_17300	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IM538_17305	COG0735	belongs to the Fur family
IM538_17310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IM538_17315	COG1121	(ABC) transporter
IM538_17320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IM538_17330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IM538_17345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IM538_17350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IM538_17355	COG2384	SAM-dependent methyltransferase
IM538_17360	COG2010	Cytochrome c
IM538_17365	COG1960	acyl-CoA dehydrogenase activity
IM538_17375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IM538_17380	COG0358	DNA primase activity
IM538_17385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IM538_17390	COG0517	IMP dehydrogenase activity
IM538_17395	COG0751	glycine-tRNA ligase activity
IM538_17405	COG1381	Involved in DNA repair and RecF pathway recombination
IM538_17415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IM538_17420	COG0295	cytidine deaminase activity
IM538_17425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IM538_17430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IM538_17435	COG1480	7TM receptor with intracellular HD hydrolase
IM538_17440	COG1702	phosphate starvation-inducible protein PhoH
IM538_17460	COG4864	UPF0365 protein
IM538_17465	COG1030	water channel activity
IM538_17470	COG1610	YqeY-like protein
IM538_17475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IM538_17485	COG1283	sodium-dependent phosphate transmembrane transporter activity
IM538_17490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IM538_17495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IM538_17500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IM538_17505	COG2264	protein methyltransferase activity
IM538_17515	COG0443	Heat shock 70 kDa protein
IM538_17520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IM538_17525	COG1420	regulation of RNA biosynthetic process
IM538_17530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IM538_17535	COG0481	GTPase activity
IM538_17545	COG0860	N-Acetylmuramoyl-L-alanine amidase
IM538_17550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IM538_17555	COG0268	Binds directly to 16S ribosomal RNA
IM538_17560	COG1466	dna polymerase III delta subunit
IM538_17570	COG0658	competence protein
IM538_17570	COG2333	competence protein COMEC
IM538_17575	COG2131	deaminase
IM538_17580	COG1555	photosystem II stabilization
IM538_17580	COG1596	polysaccharide export
IM538_17590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IM538_17595	COG2226	methyltransferase
IM538_17600	COG0799	negative regulation of ribosome biogenesis
IM538_17605	COG1713	HD superfamily hydrolase involved in NAD metabolism
IM538_17610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IM538_17615	COG1534	Rna-binding protein
IM538_17625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IM538_17630	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IM538_17640	COG0688	phosphatidylethanolamine metabolic process
IM538_17645	COG1164	Oligoendopeptidase f
IM538_17675	COG0626	cystathionine gamma-synthase activity
IM538_17680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IM538_17685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IM538_17690	COG2226	methyltransferase
IM538_17705	COG0768	penicillin binding
IM538_17710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IM538_17715	COG0572	uridine kinase
IM538_17720	COG0826	peptidase U32
IM538_17725	COG0826	peptidase U32
IM538_17730	COG4122	O-methyltransferase activity
IM538_17735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IM538_17740	COG3906	Belongs to the UPF0473 family
IM538_17745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IM538_17750	COG4472	Bacterial protein of unknown function (DUF965)
IM538_17755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IM538_17760	COG0628	permease
IM538_17780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IM538_17790	COG0482	sulfurtransferase activity
IM538_17795	COG1104	cysteine desulfurase activity
IM538_17800	COG1959	2 iron, 2 sulfur cluster binding
IM538_17805	COG2364	Membrane
IM538_17810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IM538_17820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IM538_17830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IM538_17835	COG0124	histidyl-tRNA synthetase
IM538_17845	COG3103	Sh3 type 3 domain protein
IM538_17845	COG0860	N-Acetylmuramoyl-L-alanine amidase
IM538_17845	COG4991	sh3 domain protein
IM538_17850	COG1490	D-aminoacyl-tRNA deacylase activity
IM538_17855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IM538_17865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IM538_17865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IM538_17870	COG5416	Lipopolysaccharide assembly protein A domain
IM538_17875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IM538_17880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IM538_17880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IM538_17895	COG2244	polysaccharide biosynthetic process
IM538_17900	COG2323	membrane
IM538_17910	COG1862	Preprotein translocase
IM538_17915	COG0343	queuine tRNA-ribosyltransferase activity
IM538_17920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IM538_17950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IM538_17955	COG1388	LysM domain
IM538_17960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IM538_17965	COG0157	Belongs to the NadC ModD family
IM538_17970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IM538_17975	COG1104	cysteine desulfurase activity
IM538_17980	COG1827	regulation of RNA biosynthetic process
IM538_17985	COG0077	Prephenate dehydratase
IM538_17990	COG4492	Belongs to the UPF0735 family
IM538_18000	COG3290	protein histidine kinase activity
IM538_18005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IM538_18010	COG2868	ribosomal protein
IM538_18015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IM538_18020	COG1530	ribonuclease E activity
IM538_18025	COG1994	Peptidase M50
IM538_18030	COG0739	heme binding
IM538_18035	COG2894	cell division
IM538_18040	COG0850	regulation of cytokinetic process
IM538_18045	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IM538_18050	COG1792	Involved in formation and maintenance of cell shape
IM538_18055	COG1077	Cell shape determining protein MreB Mrl
IM538_18060	COG2003	Belongs to the UPF0758 family
IM538_18095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IM538_18105	COG1459	type II secretion system
IM538_18115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IM538_18140	COG0285	dihydrofolate synthase activity
IM538_18145	COG0525	valine-tRNA ligase activity
IM538_18155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IM538_18160	COG1388	LysM domain
IM538_18160	COG1388	LysM domain
IM538_18165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IM538_18170	COG0113	porphobilinogen synthase activity
IM538_18180	COG0181	hydroxymethylbilane synthase activity
IM538_18185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IM538_18200	COG1126	abc transporter atp-binding protein
IM538_18205	COG0765	amino acid transport
IM538_18210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM538_18215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IM538_18220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IM538_18225	COG1067	ATP-dependent peptidase activity
IM538_18225	COG0470	DNA polymerase III
IM538_18230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IM538_18235	COG0544	peptidyl-prolyl cis-trans isomerase activity
IM538_18240	COG1477	protein flavinylation
IM538_18240	COG0457	Tetratricopeptide repeat
IM538_18250	COG0622	Phosphoesterase
IM538_18255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IM538_18265	COG5401	PFAM Sporulation and spore germination
IM538_18270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IM538_18275	COG1846	Transcriptional regulator
IM538_18280	COG2197	response regulator
IM538_18285	COG0824	Thioesterase
IM538_18290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IM538_18295	COG1053	succinate dehydrogenase
IM538_18300	COG2009	succinate dehydrogenase
IM538_18305	COG1719	4-vinyl reductase, 4VR
IM538_18320	COG3118	belongs to the thioredoxin family
IM538_18325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IM538_18330	COG2086	electron transfer activity
IM538_18335	COG1024	Enoyl-CoA hydratase
IM538_18340	COG1309	transcriptional regulator
IM538_18345	COG0318	PFAM AMP-dependent synthetase and ligase
IM538_18350	COG3766	membrane
IM538_18355	COG1193	negative regulation of DNA recombination
IM538_18360	COG1796	DNA polymerase
IM538_18360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IM538_18365	COG1286	toxin biosynthetic process
IM538_18370	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IM538_18375	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IM538_18380	COG0072	phenylalanine-tRNA ligase activity
IM538_18380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IM538_18385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IM538_18390	COG5522	Integral membrane protein (intg_mem_TP0381)
IM538_18395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM538_18405	COG1363	Peptidase, m42
IM538_18420	COG0398	Pfam SNARE associated Golgi protein
IM538_18425	COG3326	Membrane
IM538_18430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IM538_18435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IM538_18440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IM538_18445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IM538_18455	COG1484	DNA-dependent DNA replication
IM538_18460	COG3611	Membrane attachment protein
IM538_18465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IM538_18475	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IM538_18480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IM538_18485	COG0237	dephospho-CoA kinase activity
IM538_18490	COG1971	Probably functions as a manganese efflux pump
IM538_18495	COG0582	viral genome integration into host DNA
IM538_18625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IM538_18630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IM538_18630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IM538_18635	COG0330	HflC and HflK could
IM538_18640	COG0330	HflC and HflK could
IM538_18650	COG5002	protein histidine kinase activity
IM538_18655	COG0745	RESPONSE REGULATOR receiver
IM538_18665	COG0039	L-malate dehydrogenase activity
IM538_18670	COG0538	isocitrate dehydrogenase activity
IM538_18675	COG0372	Belongs to the citrate synthase family
IM538_18680	COG2707	UPF0756 membrane protein
IM538_18685	COG0628	permease
IM538_18690	COG3030	protein affecting phage T7 exclusion by the F plasmid
IM538_18700	COG0205	6-phosphofructokinase activity
IM538_18705	COG0825	malonyl-CoA metabolic process
IM538_18710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IM538_18715	COG2186	Transcriptional regulator
IM538_18720	COG0281	malic enzyme
IM538_18725	COG0587	DNA-directed DNA polymerase activity
IM538_18745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IM538_18755	COG4109	DRTGG domain
IM538_18765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IM538_18770	COG0006	proline dipeptidase activity
IM538_18795	COG0589	response to stress
IM538_18805	COG0521	Mo-molybdopterin cofactor biosynthetic process
IM538_18815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IM538_18820	COG0827	DNA restriction-modification system
IM538_18825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IM538_18830	COG3874	Sporulation protein YtfJ
IM538_18840	COG1714	RDD family
IM538_18845	COG0616	signal peptide processing
IM538_18850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IM538_18855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM538_18865	COG0301	tRNA thio-modification
IM538_18870	COG1104	cysteine desulfurase activity
IM538_18875	COG1114	Component of the transport system for branched-chain amino acids
IM538_18880	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IM538_18885	COG1309	transcriptional regulator
IM538_18890	COG1956	GAF domain-containing protein
IM538_18895	COG0626	cystathionine gamma-synthase activity
IM538_18900	COG2199	diguanylate cyclase activity
IM538_18900	COG2203	Gaf domain
IM538_18905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IM538_18920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM538_18925	COG0454	-acetyltransferase
IM538_18930	COG0517	IMP dehydrogenase activity
IM538_18935	COG0123	including yeast histone deacetylase and acetoin utilization protein
IM538_18940	COG1609	Transcriptional regulator
IM538_18945	COG1605	Chorismate mutase
IM538_18945	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IM538_18955	COG3118	belongs to the thioredoxin family
IM538_18960	COG4980	gas vesicle protein
IM538_18965	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IM538_18970	COG2309	aminopeptidase activity
IM538_18975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IM538_18985	COG1674	ftsk spoiiie
IM538_18990	COG4848	Belongs to the UPF0354 family
IM538_18995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM538_19010	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IM538_19015	COG1363	Peptidase, m42
IM538_19020	COG5584	Small secreted protein
IM538_19025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM538_19030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IM538_19045	COG0510	thiamine kinase activity
IM538_19050	COG1523	belongs to the glycosyl hydrolase 13 family
IM538_19055	COG1597	lipid kinase activity
IM538_19060	COG1278	Cold shock
IM538_19070	COG1346	cytolysis
IM538_19075	COG1380	Effector of murein hydrolase LrgA
IM538_19085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IM538_19095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM538_19105	COG1349	DNA-binding transcription factor activity
IM538_19110	COG1187	pseudouridine synthase activity
IM538_19120	COG2244	polysaccharide biosynthetic process
IM538_19130	COG2081	HI0933 family
IM538_19140	COG1757	Na H antiporter
IM538_19145	COG2239	Acts as a magnesium transporter
IM538_19180	COG0287	Prephenate dehydrogenase
IM538_19190	COG1183	phosphatidylcholine synthase activity
IM538_19215	COG4717	serine-type aminopeptidase activity
IM538_19220	COG0420	3'-5' exonuclease activity
IM538_19225	COG1612	heme a metabolic process
IM538_19235	COG0534	Mate efflux family protein
IM538_19240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM538_19245	COG0495	leucyl-tRNA aminoacylation
IM538_19270	COG1131	(ABC) transporter
IM538_19275	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_19280	COG2610	gluconate transmembrane transporter activity
IM538_19285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IM538_19290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IM538_19300	COG2814	Major facilitator Superfamily
IM538_19315	COG1242	4 iron, 4 sulfur cluster binding
IM538_19320	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IM538_19330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IM538_19335	COG4990	cell redox homeostasis
IM538_19340	COG0367	asparagine synthase
IM538_19350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IM538_19365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IM538_19370	COG2271	Major facilitator Superfamily
IM538_19375	COG0277	FAD linked oxidase domain protein
IM538_19385	COG1794	racemase activity, acting on amino acids and derivatives
IM538_19390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IM538_19405	COG4974	Belongs to the 'phage' integrase family
IM538_19410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IM538_19460	COG2207	Transcriptional regulator
IM538_19470	COG1506	peptidase
IM538_19475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IM538_19480	COG1116	anion transmembrane transporter activity
IM538_19485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IM538_19490	COG0494	nUDIX hydrolase
IM538_19515	COG0783	Belongs to the Dps family
IM538_19525	COG0154	amidase activity
IM538_19535	COG1854	S-ribosylhomocysteine lyase activity
IM538_19540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IM538_19575	COG4948	Mandelate Racemase Muconate Lactonizing
IM538_19580	COG0318	PFAM AMP-dependent synthetase and ligase
IM538_19585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IM538_19590	COG0596	Alpha beta hydrolase
IM538_19595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IM538_19600	COG1169	isochorismate synthase
IM538_19605	COG1575	Belongs to the MenA family. Type 1 subfamily
IM538_19610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IM538_19630	COG0058	SHG alpha-glucan phosphorylase activity
IM538_19635	COG0297	glycogen (starch) synthase activity
IM538_19640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IM538_19645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IM538_19785	COG1595	DNA-templated transcription, initiation
IM538_19800	COG0318	PFAM AMP-dependent synthetase and ligase
IM538_19805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM538_19810	COG4876	unkown
IM538_19815	COG4980	gas vesicle protein
IM538_19835	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IM538_19850	COG0697	spore germination
IM538_19865	COG0489	protein tyrosine kinase activity
IM538_19870	COG3944	biosynthesis protein
IM538_19875	COG2353	YceI-like domain
IM538_19885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IM538_19890	COG1278	Cold shock
IM538_19900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IM538_19910	COG0166	Belongs to the GPI family
IM538_19915	COG1979	alcohol dehydrogenase
IM538_19920	COG2155	Conserved Protein
IM538_19925	COG1098	S1 RNA binding domain
IM538_19945	COG2267	carboxylic ester hydrolase activity
IM538_19955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IM538_19965	COG0733	neurotransmitter:sodium symporter activity
IM538_19980	COG0791	NLP P60 protein
IM538_19980	COG1388	LysM domain
IM538_19985	COG1388	LysM domain
IM538_19985	COG0791	NLP P60 protein
IM538_19990	COG5018	Exonuclease
IM538_19995	COG2814	Major facilitator Superfamily
IM538_20005	COG2111	Na H antiporter
IM538_20005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IM538_20010	COG2111	Na H antiporter
IM538_20015	COG1006	Multisubunit Na H antiporter MnhC subunit
IM538_20020	COG0651	ATP synthesis coupled electron transport
IM538_20025	COG1863	multisubunit Na H antiporter MnhE subunit
IM538_20030	COG2212	antiporter activity
IM538_20035	COG1320	monovalent cation:proton antiporter activity
IM538_20040	COG2050	protein possibly involved in aromatic compounds catabolism
IM538_20045	COG2133	pyrroloquinoline quinone binding
IM538_20055	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_20075	COG0730	response to heat
IM538_20080	COG5002	protein histidine kinase activity
IM538_20085	COG0745	RESPONSE REGULATOR receiver
IM538_20095	COG1834	amidinotransferase
IM538_20105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IM538_20110	COG1268	BioY protein
IM538_20125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IM538_20135	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IM538_20145	COG3584	3D domain protein
IM538_20165	COG1252	NADH dehydrogenase
IM538_20170	COG0492	ferredoxin-NADP+ reductase activity
IM538_20175	COG0316	Belongs to the HesB IscA family
IM538_20180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IM538_20185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IM538_20195	COG4844	belongs to the
IM538_20200	COG1252	NADH dehydrogenase
IM538_20205	COG4837	Protein of unknown function (DUF1462)
IM538_20210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IM538_20215	COG0083	homoserine kinase activity
IM538_20220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IM538_20225	COG0460	homoserine dehydrogenase
IM538_20230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IM538_20235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IM538_20240	COG0647	UMP catabolic process
IM538_20245	COG2445	Protein of unknown function DUF86
IM538_20250	COG5001	Diguanylate cyclase
IM538_20250	COG3300	MHYT domain
IM538_20265	COG4470	Protein conserved in bacteria
IM538_20275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IM538_20280	COG0739	heme binding
IM538_20290	COG0733	neurotransmitter:sodium symporter activity
IM538_20295	COG1757	Na H antiporter
IM538_20310	COG3377	Domain of unknown function (DUF1805)
IM538_20315	COG0730	response to heat
IM538_20320	COG1801	Protein of unknown function DUF72
IM538_20330	COG0719	Fe-S assembly protein
IM538_20335	COG0822	iron-sulfur transferase activity
IM538_20340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IM538_20345	COG0719	Fe-S assembly protein
IM538_20350	COG0396	ATPase activity
IM538_20360	COG1464	Belongs to the NlpA lipoprotein family
IM538_20365	COG2011	ABC-type metal ion transport system permease component
IM538_20370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IM538_20375	COG2873	o-acetylhomoserine
IM538_20390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM538_20395	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IM538_20405	COG0509	glycine decarboxylation via glycine cleavage system
IM538_20410	COG1393	Belongs to the ArsC family
IM538_20415	COG1960	acyl-CoA dehydrogenase activity
IM538_20420	COG0183	Belongs to the thiolase family
IM538_20425	COG1250	3-hydroxyacyl-CoA dehydrogenase
IM538_20425	COG1024	Enoyl-CoA hydratase
IM538_20445	COG5577	PFAM Coat F domain
IM538_20460	COG1120	ATPase activity
IM538_20465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM538_20470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM538_20475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IM538_20480	COG0673	inositol 2-dehydrogenase activity
IM538_20485	COG1278	Cold shock
IM538_20490	COG1028	Short-chain dehydrogenase reductase Sdr
IM538_20525	COG0463	Glycosyl transferase, family 2
IM538_20535	COG1686	Belongs to the peptidase S11 family
IM538_20545	COG3885	ferrous iron binding
IM538_20545	COG2078	PFAM AMMECR1 domain protein
IM538_20555	COG2217	Heavy metal translocating P-type atpase
IM538_20560	COG2608	mercury ion transmembrane transporter activity
IM538_20565	COG1937	Protein conserved in bacteria
IM538_20570	COG0519	Catalyzes the synthesis of GMP from XMP
IM538_20575	COG1063	alcohol dehydrogenase
IM538_20580	COG2409	Drug exporters of the RND superfamily
IM538_20580	COG1033	growth of symbiont in host cell
IM538_20585	COG1846	Transcriptional regulator
IM538_20590	COG2199	diguanylate cyclase activity
IM538_20600	COG1132	(ABC) transporter
IM538_20615	COG2186	Transcriptional regulator
IM538_20630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM538_20635	COG1968	undecaprenyl-diphosphatase activity
IM538_20655	COG5002	protein histidine kinase activity
IM538_20665	COG0745	RESPONSE REGULATOR receiver
IM538_20680	COG3300	MHYT domain
IM538_20680	COG5001	Diguanylate cyclase
IM538_20685	COG0840	transmembrane signaling receptor activity
IM538_20685	COG5278	phosphoserine phosphatase activity
IM538_20690	COG0835	chemotaxis
IM538_20700	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IM538_20705	COG5002	protein histidine kinase activity
IM538_20710	COG0745	RESPONSE REGULATOR receiver
IM538_20715	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IM538_20720	COG1131	(ABC) transporter
IM538_20755	COG1045	serine acetyltransferase
IM538_20760	COG0557	exoribonuclease II activity
IM538_20765	COG1647	Serine aminopeptidase, S33
IM538_20770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM538_20780	COG0148	phosphopyruvate hydratase activity
IM538_20795	COG0126	phosphoglycerate kinase activity
IM538_20800	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IM538_20815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IM538_20830	COG0740	serine-type endopeptidase activity
IM538_20840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IM538_20845	COG1481	regulation of sporulation
IM538_20850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IM538_20855	COG1660	Displays ATPase and GTPase activities
IM538_20860	COG1051	belongs to the nudix hydrolase family
IM538_20865	COG0492	ferredoxin-NADP+ reductase activity
IM538_20870	COG0457	Tetratricopeptide repeat
IM538_20875	COG0140	phosphoribosyl-ATP diphosphatase activity
IM538_20875	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IM538_20880	COG0107	imidazoleglycerol-phosphate synthase activity
IM538_20885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IM538_20890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IM538_20895	COG0131	Imidazoleglycerol-phosphate dehydratase
IM538_20900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IM538_20910	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IM538_20920	COG1454	alcohol dehydrogenase
IM538_20920	COG1012	belongs to the aldehyde dehydrogenase family
IM538_20935	COG0110	maltose O-acetyltransferase activity
IM538_20940	COG0546	phosphoglycolate phosphatase activity
IM538_20945	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IM538_20955	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IM538_20965	COG5001	Diguanylate cyclase
IM538_20965	COG2203	Gaf domain
IM538_20965	COG3706	GGDEF domain
IM538_20965	COG4251	negative regulation of phosphorylation
IM538_20970	COG1950	PFAM Membrane protein of
IM538_20980	COG3595	metallopeptidase activity
IM538_20995	COG0556	nucleotide-excision repair
IM538_21025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IM538_21035	COG5001	Diguanylate cyclase
IM538_21035	COG3300	MHYT domain
IM538_21040	COG3314	Sporulation integral membrane protein YlbJ
IM538_21060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM538_21075	COG0793	Belongs to the peptidase S41A family
IM538_21075	COG3409	Peptidoglycan-binding domain 1 protein
IM538_21085	COG0456	acetyltransferase
IM538_21095	COG2249	NAD(P)H dehydrogenase (quinone) activity
IM538_21105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IM538_21115	COG0739	heme binding
IM538_21120	COG2177	Part of the ABC transporter FtsEX involved in
IM538_21125	COG2884	Cell division ATP-binding protein ftsE
IM538_21135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IM538_21140	COG3290	protein histidine kinase activity
IM538_21140	COG0840	transmembrane signaling receptor activity
IM538_21150	COG0653	protein targeting
IM538_21155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IM538_21160	COG3437	response regulator, receiver
IM538_21160	COG0784	Response regulator, receiver
IM538_21175	COG1516	flagellar protein fliS
IM538_21180	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IM538_21185	COG1334	flagellar protein FlaG
IM538_21190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IM538_21200	COG0463	Glycosyl transferase, family 2
IM538_21210	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IM538_21215	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IM538_21225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IM538_21230	COG1256	bacterial-type flagellum assembly
IM538_21230	COG4786	Flagellar basal body rod
IM538_21235	COG3418	PFAM FlgN family protein
IM538_21240	COG2747	anti-sigma28 factor FlgM
IM538_21250	COG1040	competence protein
IM538_21260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IM538_21265	COG1307	EDD domain protein, DegV family
IM538_21285	COG2197	response regulator
IM538_21290	COG4585	Histidine kinase
IM538_21295	COG1739	Uncharacterized protein family UPF0029
IM538_21300	COG1316	TRANSCRIPTIONal
IM538_21305	COG0860	N-Acetylmuramoyl-L-alanine amidase
IM538_21315	COG2385	sporulation resulting in formation of a cellular spore
IM538_21315	COG2247	cell wall binding repeat
IM538_21340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IM538_21365	COG0482	sulfurtransferase activity
IM538_21385	COG0673	inositol 2-dehydrogenase activity
IM538_21400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM538_21425	COG0653	protein targeting
IM538_21440	COG1388	LysM domain
IM538_21440	COG0791	NLP P60 protein
IM538_21445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM538_21460	COG0793	Belongs to the peptidase S41A family
IM538_21465	COG0840	transmembrane signaling receptor activity
IM538_21480	COG1388	LysM domain
IM538_21480	COG1388	LysM domain
IM538_21480	COG1705	Flagellar rod assembly protein muramidase FlgJ
IM538_21480	COG1705	Flagellar rod assembly protein muramidase FlgJ
IM538_21530	COG0681	Belongs to the peptidase S26 family
IM538_21575	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IM538_21580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IM538_21585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IM538_21600	COG0438	transferase activity, transferring glycosyl groups
IM538_21615	COG1045	serine acetyltransferase
IM538_21620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IM538_21625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IM538_21690	COG0655	NAD(P)H dehydrogenase (quinone) activity
IM538_21735	COG0028	Belongs to the TPP enzyme family
IM538_21765	COG0860	N-Acetylmuramoyl-L-alanine amidase
IM538_21765	COG3103	Sh3 type 3 domain protein
IM538_21765	COG4991	sh3 domain protein
IM538_21785	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IM538_21790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM538_21795	COG0765	amino acid transport
IM538_21800	COG1126	abc transporter atp-binding protein
IM538_21845	COG2199	diguanylate cyclase activity
IM538_21845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IM538_21850	COG1404	Belongs to the peptidase S8 family
IM538_21865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IM538_21875	COG3764	Sortase (surface protein transpeptidase)
IM538_21890	COG1404	Belongs to the peptidase S8 family
IM538_21895	COG3858	chitin binding
IM538_21900	COG1054	Belongs to the UPF0176 family
IM538_21910	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IM538_21920	COG1376	ErfK ybiS ycfS ynhG family protein
IM538_21945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IM538_21950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IM538_22010	COG0726	polysaccharide deacetylase
IM538_22035	COG3852	Histidine kinase
IM538_22065	COG2197	response regulator
IM538_22070	COG4585	Histidine kinase
IM538_22095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IM538_22100	COG5002	protein histidine kinase activity
IM538_22120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM538_22130	COG1316	TRANSCRIPTIONal
IM538_22150	COG1404	Belongs to the peptidase S8 family
IM538_22165	COG1404	Belongs to the peptidase S8 family
IM538_22180	COG1404	Belongs to the peptidase S8 family
IM538_22195	COG0737	Belongs to the 5'-nucleotidase family
IM538_22195	COG1525	nuclease
IM538_22195	COG4085	toxin activity
IM538_22215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IM538_22240	COG3340	Belongs to the peptidase S51 family
IM538_22270	COG1294	oxidase, subunit
IM538_22275	COG1271	oxidase subunit
IM538_22290	COG3852	Histidine kinase
IM538_22305	COG4585	Histidine kinase
IM538_22315	COG4715	Zinc finger, swim domain protein
IM538_22320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IM538_22330	COG0629	single-stranded DNA binding
IM538_22355	COG4786	Flagellar basal body rod
IM538_22360	COG4786	Flagellar basal body rod
IM538_22365	COG1077	Cell shape determining protein MreB Mrl
IM538_22370	COG1609	Transcriptional regulator
IM538_22375	COG2176	DNA-directed DNA polymerase activity
IM538_22375	COG5002	protein histidine kinase activity
IM538_22385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IM538_22405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IM538_22410	COG2059	Chromate
IM538_22415	COG2059	Chromate
IM538_22420	COG0405	Gamma-glutamyltransferase
IM538_22425	COG1522	sequence-specific DNA binding
IM538_22435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IM538_22440	COG1131	(ABC) transporter
IM538_22450	COG0739	heme binding
IM538_22460	COG2385	sporulation resulting in formation of a cellular spore
IM538_22465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IM538_22475	COG4836	Membrane
IM538_22480	COG1007	ATP synthesis coupled electron transport
IM538_22485	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM538_22490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IM538_22495	COG0713	ATP synthesis coupled electron transport
IM538_22510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IM538_22515	COG0649	NAD binding
IM538_22520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM538_22525	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM538_22530	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM538_22560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IM538_22565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IM538_22570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IM538_22575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IM538_22580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IM538_22585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IM538_22590	COG0356	it plays a direct role in the translocation of protons across the membrane
IM538_22605	COG1404	Belongs to the peptidase S8 family
IM538_22610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IM538_22635	COG0698	ribose 5-phosphate isomerase
IM538_22640	COG0840	transmembrane signaling receptor activity
IM538_22650	COG1971	Probably functions as a manganese efflux pump
IM538_22655	COG0009	L-threonylcarbamoyladenylate synthase
IM538_22660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IM538_22670	COG2890	protein-(glutamine-N5) methyltransferase activity
IM538_22675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IM538_22680	COG0789	Transcriptional regulator
IM538_22695	COG1435	thymidine kinase activity
IM538_22705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IM538_22710	COG1494	fructose-1,6-bisphosphatase
IM538_22720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IM538_22725	COG0191	fructose-bisphosphate aldolase activity
IM538_22730	COG2204	response regulator
IM538_22735	COG4821	SIS domain
IM538_22740	COG0504	CTP synthase activity
IM538_22750	COG1703	isobutyryl-CoA mutase activity
IM538_22750	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM538_22750	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM538_22760	COG1960	acyl-CoA dehydrogenase activity
IM538_22765	COG1960	acyl-CoA dehydrogenase activity
IM538_22770	COG1250	3-hydroxyacyl-CoA dehydrogenase
IM538_22775	COG0183	Belongs to the thiolase family
IM538_22780	COG0247	lactate metabolic process
IM538_22780	COG2181	nitrate reductase activity
IM538_22785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IM538_22810	COG0018	arginyl-trna synthetase
IM538_22815	COG4506	Protein conserved in bacteria
IM538_22820	COG0010	Belongs to the arginase family
IM538_22825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IM538_22830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM538_22840	COG1994	Peptidase M50
IM538_22850	COG2252	PERMEase
IM538_22855	COG3465	dGTPase activity
IM538_22860	COG1078	dGTPase activity
IM538_22865	COG4844	belongs to the
IM538_22875	COG0095	Lipoate-protein ligase
IM538_22880	COG0280	phosphate acetyltransferase
IM538_22890	COG3773	Cell wall hydrolase
IM538_22900	COG2363	Small membrane protein
IM538_22905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IM538_22915	COG1984	allophanate hydrolase subunit 2
IM538_22935	COG1250	3-hydroxyacyl-CoA dehydrogenase
IM538_22940	COG0456	acetyltransferase
IM538_22950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IM538_22955	COG0776	regulation of translation
IM538_22965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IM538_22970	COG0456	acetyltransferase
IM538_23015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IM538_23015	COG0723	plastoquinol--plastocyanin reductase activity
IM538_23020	COG0667	Aldo Keto reductase
IM538_23030	COG0366	Alpha amylase catalytic
IM538_23035	COG1309	transcriptional regulator
IM538_23040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM538_23050	COG2966	Psort location CytoplasmicMembrane, score
IM538_23070	COG1132	(ABC) transporter
IM538_23075	COG1454	alcohol dehydrogenase
IM538_23080	COG1012	belongs to the aldehyde dehydrogenase family
IM538_23085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM538_23100	COG2814	Major facilitator Superfamily
IM538_23115	COG2197	response regulator
IM538_23120	COG4585	Histidine kinase
IM538_23150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IM538_23155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IM538_23160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IM538_23170	COG0038	chloride channel
IM538_23175	COG1960	acyl-CoA dehydrogenase activity
IM538_23180	COG2514	catechol 2,3-dioxygenase activity
IM538_23190	COG0247	lactate metabolic process
IM538_23195	COG0277	FAD linked oxidase domain protein
IM538_23200	COG1620	l-lactate permease
IM538_23205	COG2186	Transcriptional regulator
IM538_23210	COG0247	lactate metabolic process
IM538_23215	COG1139	Iron-sulfur cluster binding protein
IM538_23220	COG1556	Lactate utilization protein
IM538_23230	COG3361	conserved protein (COG2071)
IM538_23235	COG1307	EDD domain protein, DegV family
IM538_23240	COG2323	membrane
IM538_23245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IM538_23255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM538_23260	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IM538_23265	COG4853	Protein conserved in bacteria
IM538_23270	COG4863	YycH protein
IM538_23275	COG5002	protein histidine kinase activity
IM538_23280	COG0745	RESPONSE REGULATOR receiver
IM538_23310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IM538_23315	COG0305	Participates in initiation and elongation during chromosome replication
IM538_23320	COG0359	binds to the 23S rRNA
IM538_23325	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IM538_23330	COG4241	membrane
IM538_23335	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IM538_23345	COG0360	Binds together with S18 to 16S ribosomal RNA
IM538_23350	COG0012	GTP binding
IM538_23355	COG0243	molybdopterin cofactor binding
IM538_23360	COG4481	Protein conserved in bacteria
IM538_23365	COG0668	transmembrane transport
IM538_23370	COG3949	Membrane
IM538_23380	COG1811	Na channel or pump
IM538_23385	COG1475	DNA binding
IM538_23390	COG1192	Involved in chromosome partitioning
IM538_23395	COG1475	DNA binding
IM538_23400	COG0357	Ribosomal RNA small subunit methyltransferase G
IM538_23405	COG0445	tRNA wobble uridine modification
IM538_23410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IM538_23415	COG1847	R3H domain protein
IM538_23430	COG0230	Belongs to the bacterial ribosomal protein bL34 family