locus-tag class description FHJ82_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FHJ82_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FHJ82_00015 ENOG410848D S4 domain protein YaaA FHJ82_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FHJ82_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHJ82_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHJ82_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FHJ82_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FHJ82_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FHJ82_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FHJ82_00095 ENOG4105BZW Glycerate kinase FHJ82_00105 ENOG4105ZMH deoxynucleoside kinase FHJ82_00115 ENOG4105VRS hydrolase family 18 FHJ82_00120 ENOG4105GTG Isochorismatase FHJ82_00125 ENOG4108Z6B deaminase FHJ82_00135 ENOG4105C6E dna polymerase iii FHJ82_00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FHJ82_00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FHJ82_00155 ENOG41067KS pro-sigma K processing FHJ82_00195 ENOG4105CDW Resistance protein FHJ82_00200 ENOG4105CXN decarboxylase FHJ82_00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FHJ82_00210 ENOG4105X0R protein from nitrogen regulatory protein P-II FHJ82_00215 ENOG4105XVJ Protein of unknown function (DUF327) FHJ82_00220 ENOG4105FA2 dna polymerase iii FHJ82_00225 ENOG4105MA4 psp1 domain protein FHJ82_00235 ENOG41060K3 Methyltransferase FHJ82_00240 ENOG4105VC4 domain protein FHJ82_00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FHJ82_00250 ENOG4105KRN Transcriptional regulator, abrb family FHJ82_00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FHJ82_00260 ENOG4105F8V Hydrolase, tatD family FHJ82_00265 ENOG41069ER domain protein FHJ82_00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FHJ82_00280 ENOG4105XFA sporulation peptidase YabG FHJ82_00285 ENOG4105W42 Veg protein FHJ82_00290 ENOG4105XEW small acid-soluble spore protein FHJ82_00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FHJ82_00300 ENOG4105DFT pur operon repressor FHJ82_00305 ENOG4105KME endoribonuclease L-psp FHJ82_00310 ENOG4105K4W Could be involved in septation (By similarity) FHJ82_00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FHJ82_00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FHJ82_00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FHJ82_00340 ENOG4108JA2 transcriptioN-repair coupling factor FHJ82_00345 ENOG4108M14 stage v sporulation protein t FHJ82_00355 ENOG4108IY2 MazG family FHJ82_00360 ENOG41082I2 s4 domain protein FHJ82_00365 ENOG4105VYY sporulation protein yabp FHJ82_00380 ENOG41060GV RNA binding s1 domain protein FHJ82_00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FHJ82_00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase FHJ82_00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FHJ82_00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FHJ82_00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FHJ82_00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase FHJ82_00440 ENOG4105C6T cysteine synthase FHJ82_00445 ENOG4105CRQ synthase (Component I) FHJ82_00450 ENOG4105DDQ anthranilate synthase FHJ82_00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FHJ82_00460 ENOG4105EEI dihydropteroate synthase FHJ82_00465 ENOG4105KRF dihydroneopterin aldolase FHJ82_00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FHJ82_00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FHJ82_00485 ENOG4105CRK lysyL-tRNA synthetase FHJ82_00570 ENOG4108Z0C Uvrb UvrC protein FHJ82_00575 ENOG41066A3 ATP guanido phosphotransferase FHJ82_00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FHJ82_00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FHJ82_00595 ENOG4105CTP PilT protein domain protein FHJ82_00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FHJ82_00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FHJ82_00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FHJ82_00615 ENOG4105D7W serine acetyltransferase FHJ82_00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) FHJ82_00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 FHJ82_00635 ENOG4105M0M Tetracycline resistance protein FHJ82_00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FHJ82_00670 ENOG4108VZM 50s ribosomal protein L10 FHJ82_00680 ENOG4107Y49 methyltransferase FHJ82_00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FHJ82_00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FHJ82_00695 ENOG4105XPM ribosomal protein FHJ82_00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FHJ82_00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FHJ82_00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FHJ82_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FHJ82_00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FHJ82_00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FHJ82_00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FHJ82_00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FHJ82_00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FHJ82_00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FHJ82_00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FHJ82_00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FHJ82_00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FHJ82_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FHJ82_00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FHJ82_00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FHJ82_00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FHJ82_00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FHJ82_00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FHJ82_00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FHJ82_00855 ENOG41067V7 50S ribosomal protein L36 FHJ82_00860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FHJ82_00865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FHJ82_00870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FHJ82_00875 ENOG4108ZT0 50S ribosomal protein l17 FHJ82_00880 ENOG4108JJB ABC transporter FHJ82_00885 ENOG4108JJB ABC transporter FHJ82_00890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FHJ82_00895 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FHJ82_00900 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FHJ82_00905 ENOG4108UJD 30S ribosomal protein S9 FHJ82_00910 ENOG4108I0C methyltransferase FHJ82_00930 ENOG4105D1F ATP-binding protein FHJ82_00945 ENOG4108NMV polysaccharide deacetylase FHJ82_01010 ENOG4108JPW Aminotransferase FHJ82_01020 ENOG4105CPQ Dehydrogenase FHJ82_01025 ENOG4105CHH sulfate transporter FHJ82_01035 ENOG4108SA1 esterase FHJ82_01055 ENOG410874W AraC family transcriptional regulator FHJ82_01060 ENOG4105EHZ conserved protein UCP016719 FHJ82_01065 ENOG4105D17 glycoside hydrolase, family 3 domain protein FHJ82_01080 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FHJ82_01090 ENOG4105EWC Purine nucleoside phosphorylase FHJ82_01120 ENOG4105EMN RNA polymerase sigma factor FHJ82_01130 ENOG4105C8B TIGR00159 family FHJ82_01135 ENOG4107U5W ybbr family FHJ82_01140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FHJ82_01170 ENOG4105BZU Histidine kinase FHJ82_01175 ENOG4105C19 ABC transporter FHJ82_01200 ENOG41067MG lrgb family FHJ82_01210 ENOG41061AU MarR family Transcriptional regulator FHJ82_01225 ENOG4105BZU Histidine kinase FHJ82_01230 ENOG4105WH1 Two component transcriptional regulator luxr family FHJ82_01235 ENOG4105CJ1 ABC, transporter FHJ82_01260 ENOG4106DDH Sporulation-specific SASP protein FHJ82_01275 ENOG4107QTZ amino acid FHJ82_01280 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FHJ82_01295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FHJ82_01300 ENOG4105CXY transporter FHJ82_01340 ENOG41065RQ ADP-ribosylation crystallin J1 FHJ82_01345 ENOG4106BHF FHJ82_01355 ENOG4107SCQ Iron-containing alcohol dehydrogenase FHJ82_01360 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FHJ82_01365 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FHJ82_01370 ENOG4107ZTW SNARE associated Golgi FHJ82_01385 ENOG4105C72 UPF0176 protein FHJ82_01395 ENOG4105CM2 brancheD-chain amino acid aminotransferase FHJ82_01400 ENOG4108IQI permease FHJ82_01405 ENOG4108J5H Homocysteine s-methyltransferase FHJ82_01415 ENOG4105CSV Glutaminase FHJ82_01445 ENOG41076HS cation diffusion facilitator family transporter FHJ82_01450 ENOG4108TVJ Nitroreductase FHJ82_01455 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FHJ82_01460 ENOG4108VGI doxx family FHJ82_01465 ENOG4105XXY Thioredoxin FHJ82_01495 ENOG4105DGI Alkaline phosphatase FHJ82_01500 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FHJ82_01505 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FHJ82_01510 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FHJ82_01515 ENOG4107EPV Aminotransferase class V FHJ82_01520 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHJ82_01525 ENOG4105J7D transcriptional regulator FHJ82_01530 ENOG4107RB3 L-asparaginase FHJ82_01535 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FHJ82_01540 ENOG41060AI SEC-C motif FHJ82_01575 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FHJ82_01585 ENOG4105DSE periplasmic solute binding protein FHJ82_01590 ENOG4105DIK (ABC) transporter FHJ82_01600 ENOG4105DEN Luciferase family FHJ82_01605 ENOG4108N0M stress protein FHJ82_01610 ENOG4106FN3 tellurium resistance protein FHJ82_01615 ENOG4106FN3 tellurium resistance protein FHJ82_01620 ENOG4107TS3 membrane protein, TerC FHJ82_01625 ENOG4108TTB tellurium resistance protein FHJ82_01635 ENOG41079KZ Major Facilitator Superfamily FHJ82_01640 ENOG4108IJ7 Glycine betaine FHJ82_01645 ENOG4107SQ8 Glycine betaine FHJ82_01675 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FHJ82_01705 ENOG4105EIG urea carboxylase-associated protein 1 FHJ82_01710 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FHJ82_01720 ENOG4105I1F Resistance protein FHJ82_01725 ENOG4108WBH protein TIM barrel FHJ82_01730 ENOG4105DJB Major Facilitator Superfamily FHJ82_01735 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FHJ82_01740 ENOG4105I82 acetyl xylan esterase FHJ82_01745 ENOG410756H nucleotidyltransferase FHJ82_01755 ENOG4105C26 Dehydrogenase FHJ82_01760 ENOG4105CK7 Sodium proline symporter FHJ82_01765 ENOG4107YHD transcriptional regulator FHJ82_01770 ENOG4105CAY ferredoxin--nadp reductase FHJ82_01775 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FHJ82_01780 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FHJ82_01785 ENOG4108IFG nitrite reductase, (NAD(P)H) FHJ82_01790 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FHJ82_01805 ENOG4105CKI cobalamin synthesis protein FHJ82_01810 ENOG4105E2A Dehydrogenase FHJ82_01815 ENOG4105HHM rdd domain containing protein FHJ82_01825 ENOG4105CS2 ec 3.2.1.21 FHJ82_01845 ENOG41080HJ 6-phospho 3-hexuloisomerase FHJ82_01850 ENOG4108VA3 3-hexulose-6-phosphate synthase FHJ82_01855 ENOG4105KVH Transcriptional regulator FHJ82_01860 ENOG4105CEY Amp-dependent synthetase and ligase FHJ82_01880 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FHJ82_01895 ENOG4105CDA abc transporter atp-binding protein FHJ82_01900 ENOG4105DRP amino acid AbC transporter FHJ82_01910 ENOG4106P55 Transcriptional regulator FHJ82_01915 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FHJ82_01920 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FHJ82_01925 ENOG41069ZX FHJ82_01930 ENOG41069ZX FHJ82_01935 ENOG4105DUX Transporter FHJ82_01950 ENOG4105E1K spore germination protein FHJ82_01975 ENOG4105EAB amino acid AbC transporter FHJ82_01980 ENOG4108HW4 amino acid AbC transporter FHJ82_01995 ENOG4108PGP mmge prpd family protein FHJ82_02005 ENOG4107WD8 ABC transporter, permease FHJ82_02010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHJ82_02015 ENOG4105BZU Histidine kinase FHJ82_02040 ENOG4105CFH Aspartokinase FHJ82_02045 ENOG4105DHS permease protein FHJ82_02050 ENOG4105CM4 permease protein FHJ82_02055 ENOG4108IPW abc transporter atp-binding protein FHJ82_02070 ENOG4105R8C Transcriptional regulator FHJ82_02075 ENOG4108DBC nitroreductase FHJ82_02080 ENOG41067V3 Antibiotic biosynthesis monooxygenase FHJ82_02085 ENOG4105YVS arsR family transcriptional regulator FHJ82_02095 ENOG4108JPW Aminotransferase FHJ82_02100 ENOG4105C26 Dehydrogenase FHJ82_02110 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FHJ82_02115 ENOG4105KTB nuclear export factor GLE1 FHJ82_02120 ENOG4108T5E Copper resistance protein FHJ82_02125 ENOG4108ZYE Transcriptional regulator FHJ82_02145 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FHJ82_02165 ENOG4105E7W lamb ycsf family protein FHJ82_02170 ENOG4105C5A transporter FHJ82_02175 ENOG4105CFM UPF0317 protein FHJ82_02180 ENOG4105P4J Allophanate hydrolase, subunit 1 FHJ82_02190 ENOG4107258 Transcriptional regulator FHJ82_02195 ENOG4105XJB lipolytic protein G-D-S-L family FHJ82_02205 ENOG41061CK Antibiotic biosynthesis monooxygenase FHJ82_02210 ENOG4107RVG penicillin-binding protein FHJ82_02215 ENOG4107QM2 Aldo Keto reductase FHJ82_02220 ENOG4105ETD TRANSCRIPTIONal FHJ82_02230 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FHJ82_02245 ENOG410606W general stress protein FHJ82_02255 ENOG4105VCH membrane FHJ82_02265 ENOG4105C9U ATP-dependent DNA helicase RecQ FHJ82_02280 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FHJ82_02285 ENOG4107R8N Glycosyl transferase, family 2 FHJ82_02295 ENOG4105C0X amino acid FHJ82_02365 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FHJ82_02380 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) FHJ82_02385 ENOG4105RXJ FHJ82_02390 ENOG4105KPY Small multidrug resistance protein FHJ82_02395 ENOG4105EU9 FHJ82_02400 ENOG4105QVS general stress protein FHJ82_02405 ENOG41082W1 Cupin 2, conserved barrel domain protein FHJ82_02420 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FHJ82_02425 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FHJ82_02430 ENOG4108MRH transcriptional regulatory protein FHJ82_02440 ENOG4106F5Q Membrane FHJ82_02445 ENOG4105CJ1 ABC, transporter FHJ82_02460 ENOG4105FDT acyl-CoA dehydrogenase FHJ82_02480 ENOG4105SZ6 Thioredoxin FHJ82_02485 ENOG4105CPF Cell wall formation (By similarity) FHJ82_02490 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FHJ82_02495 ENOG4105C1J atp-dependent rna helicase FHJ82_02500 ENOG410905X membrane-flanked domain protein FHJ82_02505 ENOG4105CKV Membrane FHJ82_02515 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FHJ82_02520 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FHJ82_02525 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FHJ82_02535 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FHJ82_02540 ENOG4107MMM Anti-sigma-factor antagonist FHJ82_02545 ENOG4105FUA antagonist FHJ82_02550 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FHJ82_02555 ENOG4107SGM protein serine threonine phosphatase FHJ82_02560 ENOG4105WN5 stage II sporulation protein FHJ82_02565 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FHJ82_02575 ENOG41064BQ Phosphatase FHJ82_02590 ENOG410906U SprT-like FHJ82_02670 ENOG4105CSH Transporter FHJ82_02675 ENOG4105K56 Transcriptional regulator FHJ82_02685 ENOG4108ZMQ domain protein FHJ82_02700 ENOG4108Z40 Transcriptional regulator FHJ82_02705 ENOG4108RYK Nad-dependent epimerase dehydratase FHJ82_02720 ENOG4105VEQ Cold shock protein FHJ82_02730 ENOG4105XTG Pfam:DUF156 FHJ82_02735 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FHJ82_02740 ENOG4105C72 UPF0176 protein FHJ82_02745 ENOG4105VFE sira family FHJ82_02750 ENOG4107TPS domain protein FHJ82_02755 ENOG4105VFE sira family FHJ82_02760 ENOG41087NI Sulfite exporter TauE/SafE FHJ82_02780 ENOG4105IRW patatin-like phospholipase family protein FHJ82_02790 ENOG41082W1 Cupin 2, conserved barrel domain protein FHJ82_02805 ENOG4105DNP FAD linked oxidase domain protein FHJ82_02815 ENOG4105PGM cation diffusion facilitator family transporter FHJ82_02820 ENOG4105H3G oxidoreductase FHJ82_02830 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FHJ82_02870 ENOG4105DQ4 alcohol dehydrogenase FHJ82_02875 ENOG4105VUF Transcriptional regulator FHJ82_02885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FHJ82_02900 ENOG4105EQ0 Major Facilitator superfamily FHJ82_02905 ENOG4108JGH Tetr family transcriptional regulator FHJ82_02910 ENOG4105T38 integral membrane protein FHJ82_02915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FHJ82_02930 ENOG4105E2A Dehydrogenase FHJ82_02935 ENOG4105PGS Spore coat protein FHJ82_02945 ENOG4105ENE Histidine kinase FHJ82_02950 ENOG4108VB1 regulatoR FHJ82_02955 ENOG4105EYF MMPL domain protein FHJ82_02975 ENOG4108JYZ YitT family FHJ82_02985 ENOG4105C2C drug resistance transporter, Bcr CflA FHJ82_02990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FHJ82_03010 ENOG41090E6 transcriptional regulator MERR family FHJ82_03025 ENOG4105F2W methyltransferase FHJ82_03030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FHJ82_03035 ENOG4105DRR Transcriptional regulator, GntR family FHJ82_03055 ENOG4105FQP Beta-lactamase FHJ82_03060 ENOG41090UD (LipO)protein FHJ82_03065 ENOG4108SUT Major Facilitator Superfamily FHJ82_03070 ENOG4108TZY GntR Family Transcriptional Regulator FHJ82_03075 ENOG4105JXH GntR family transcriptional regulator FHJ82_03080 ENOG4105DJ2 Major Facilitator Superfamily FHJ82_03160 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FHJ82_03165 ENOG4105K8N protein family UPF0079, ATPase FHJ82_03170 ENOG41072GX Peptidase M22 Glycoprotease FHJ82_03175 ENOG410801F ribosomal-protein-alanine acetyltransferase FHJ82_03180 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FHJ82_03185 ENOG4105C5H ABC transporter FHJ82_03190 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FHJ82_03195 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FHJ82_03200 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FHJ82_03205 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FHJ82_03215 ENOG4108TYN CAAX amino terminal protease family protein FHJ82_03225 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FHJ82_03255 ENOG4105PGZ NB-ARC domain FHJ82_03260 ENOG4105CPQ Dehydrogenase FHJ82_03265 ENOG4105CT4 transporter FHJ82_03280 ENOG41087YS Phage shock protein A FHJ82_03285 ENOG4105DQX Zinc finger domain FHJ82_03290 ENOG4108WV1 Pfam:DUF477 FHJ82_03300 ENOG4105EXC Acyl-transferase FHJ82_03305 ENOG4108P49 AntiSigma factor FHJ82_03310 ENOG4105JVQ RNA Polymerase FHJ82_03335 ENOG4107STQ Multicopper oxidase FHJ82_03340 ENOG4105C85 amino acid FHJ82_03345 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FHJ82_03360 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FHJ82_03380 ENOG4105C7N Xanthine uracil vitamin C permease FHJ82_03405 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FHJ82_03410 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FHJ82_03415 ENOG4105C83 adenylosuccinate lyase FHJ82_03420 ENOG4105C8V SAICAR synthetase FHJ82_03425 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FHJ82_03430 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FHJ82_03435 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FHJ82_03445 ENOG4105CXB phosphoribosylaminoimidazole synthetase FHJ82_03450 ENOG4108V3E phosphoribosylglycinamide formyltransferase FHJ82_03460 ENOG4105C12 Phosphoribosylglycinamide synthetase FHJ82_03475 ENOG4108R5T secreted protein FHJ82_03480 ENOG4105KGF protein, YerC YecD FHJ82_03485 ENOG4105CBC glutamate synthase FHJ82_03500 ENOG4105C4R Atp-dependent dna helicase FHJ82_03505 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FHJ82_03515 ENOG4105CRN Aminoglycoside phosphotransferase FHJ82_03520 ENOG4105KT7 mgtC SapB transporter FHJ82_03525 ENOG4105CK7 Sodium proline symporter FHJ82_03530 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FHJ82_03535 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FHJ82_03540 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FHJ82_03545 ENOG4108IG5 Transcriptional regulator FHJ82_03555 ENOG4105CBD Diacylglycerol kinase FHJ82_03560 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FHJ82_03570 ENOG4105CJ1 ABC, transporter FHJ82_03615 ENOG4105CDY transcriptional regulatory protein FHJ82_03625 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FHJ82_03640 ENOG4105WEF catalase FHJ82_03645 ENOG4105M18 -acetyltransferase FHJ82_03655 ENOG4105H67 Protein of unknown function (DUF421) FHJ82_03660 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FHJ82_03665 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FHJ82_03690 ENOG4106I4J membrane FHJ82_03695 ENOG41082F9 transcriptional regulator FHJ82_03700 ENOG41061H0 Monooxygenase FHJ82_03705 ENOG4108R1P FHJ82_03710 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FHJ82_03715 ENOG4105E0M Sulfatase FHJ82_03720 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FHJ82_03730 ENOG41090R9 glycosyltransferase FHJ82_03735 ENOG4107R51 Glycosyl transferase, family 2 FHJ82_03740 ENOG41090R9 glycosyltransferase FHJ82_03745 ENOG4105EU0 Major facilitator Superfamily FHJ82_03750 ENOG4105CUB amino acid FHJ82_03755 ENOG4105C26 Dehydrogenase FHJ82_03760 ENOG4105FKZ Methyl-accepting chemotaxis FHJ82_03765 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FHJ82_03770 ENOG4107TVC Glycosyl transferase, family 2 FHJ82_03775 ENOG4105C5H ABC transporter FHJ82_03780 ENOG4107SWG transcriptional regulator MERR family FHJ82_03785 ENOG4105DXB Major Facilitator superfamily FHJ82_03790 ENOG4105C5H ABC transporter FHJ82_03795 ENOG4105FDU atp-dependent rna helicase FHJ82_03805 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FHJ82_03820 ENOG4108J20 pectate lyase FHJ82_03825 ENOG4107QPK )-transporter FHJ82_03850 ENOG4108MRH transcriptional regulatory protein FHJ82_03875 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) FHJ82_03880 ENOG4108RPX mosc domain containing protein FHJ82_03900 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FHJ82_03940 ENOG4105C5Y PTS System FHJ82_03945 ENOG4105CG3 alpha amylase, catalytic region FHJ82_03950 ENOG4107414 GntR family transcriptional regulator FHJ82_03955 ENOG4108RCM Nitroreductase FHJ82_03970 ENOG4105CGH 5'-nucleotidase FHJ82_03975 ENOG4107RKG DJ-1/PfpI family FHJ82_03980 ENOG4105ETE Transcriptional regulator (LacI family FHJ82_03990 ENOG4105FF2 Type I DHQase FHJ82_04005 ENOG4105KJF protein tyrosine phosphatase FHJ82_04015 ENOG4107U9T Pfam:Ribonuclease_BN FHJ82_04020 ENOG4108ISG Major Facilitator FHJ82_04025 ENOG4105UPD Calcium Proton FHJ82_04035 ENOG4105D8X mechanosensitive ion channel FHJ82_04070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHJ82_04080 ENOG4106KE4 Dehydrogenase FHJ82_04090 ENOG4105D7N magnesium and cobalt transport protein CorA FHJ82_04100 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FHJ82_04125 ENOG4107RUY (E1 component), alpha subunit FHJ82_04135 ENOG4107QKR Dehydrogenase FHJ82_04145 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FHJ82_04155 ENOG4105F8D glycoside hydrolase family 4 FHJ82_04160 ENOG4108Q3X Transcriptional regulator FHJ82_04165 ENOG4105CI1 PTS System FHJ82_04175 ENOG4105BZ1 (ABC) transporter FHJ82_04180 ENOG4105BZ1 (ABC) transporter FHJ82_04190 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FHJ82_04195 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FHJ82_04200 ENOG4105U3E Transcriptional regulator FHJ82_04205 ENOG4105DYS nad(p)h dehydrogenase (quinone) FHJ82_04210 ENOG4105H93 Acyltransferase family FHJ82_04225 ENOG4108YYS metal-dependent hydrolase (By similarity) FHJ82_04230 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHJ82_04235 ENOG410834F Transcriptional regulator FHJ82_04245 ENOG4105JAB phenazine biosynthesis protein, phzf family FHJ82_04250 ENOG4107Y03 Nitroreductase FHJ82_04265 ENOG4105ECP epimerase FHJ82_04270 ENOG410902V Modulates RecA activity (By similarity) FHJ82_04280 ENOG4105F27 Major Facilitator FHJ82_04290 ENOG4108TCS Glutamyl endopeptidase FHJ82_04310 ENOG4106AKJ FHJ82_04315 ENOG4105D74 hydrolase FHJ82_04320 ENOG4105CKK Glycosyl transferase, family 2 FHJ82_04325 ENOG4105EJV Membrane FHJ82_04330 ENOG41067AE Membrane-bound metal-dependent hydrolase FHJ82_04335 ENOG4105CEN a g-specific adenine glycosylase FHJ82_04340 ENOG4106BXE FHJ82_04345 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FHJ82_04365 ENOG4105BZ1 (ABC) transporter FHJ82_04370 ENOG4107NBY Membrane FHJ82_04375 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FHJ82_04380 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHJ82_04385 ENOG4105G5W regulator Fur family FHJ82_04390 ENOG4105TUA UPF0295 protein FHJ82_04500 ENOG4105EC3 peptidase S51, dipeptidase E FHJ82_04505 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FHJ82_04510 ENOG4105DNP FAD linked oxidase domain protein FHJ82_04520 ENOG4105DEF Extracellular solute-binding protein, family 5 FHJ82_04530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHJ82_04535 ENOG4105C3U ABC transporter FHJ82_04540 ENOG4108JQ7 (ABC) transporter FHJ82_04560 ENOG4105E2Y ABC, transporter FHJ82_04565 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FHJ82_04570 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FHJ82_04580 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FHJ82_04585 ENOG4107D63 FHJ82_04590 ENOG4105VZ8 Transcriptional regulator FHJ82_04605 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FHJ82_04615 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FHJ82_04635 ENOG4105CYN Serine protein kinase FHJ82_04650 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FHJ82_04655 ENOG4105CW7 secretion protein, HlyD family FHJ82_04660 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHJ82_04665 ENOG4105CS1 NAD(P)H quinone oxidoreductase FHJ82_04680 ENOG4108TU7 Inherit from COG: (ABC) transporter FHJ82_04685 ENOG4105VEQ Cold shock protein FHJ82_04700 ENOG4105BZU Histidine kinase FHJ82_04740 ENOG4108YBP pseudouridine synthase FHJ82_04750 ENOG41080XP Cbs domain FHJ82_04755 ENOG4107YBY Hydrolase FHJ82_04760 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FHJ82_04765 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FHJ82_04770 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FHJ82_04780 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FHJ82_04785 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FHJ82_04795 ENOG4105BZU Histidine kinase FHJ82_04800 ENOG4105WH1 Two component transcriptional regulator luxr family FHJ82_04840 ENOG4105ED1 spovr family FHJ82_04845 ENOG4105G6Z alkaline phosphatase FHJ82_04860 ENOG4105BZN citrate synthase FHJ82_04865 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FHJ82_04870 ENOG4105CUB amino acid FHJ82_04875 ENOG4105C8J )-transporter FHJ82_04885 ENOG4105J37 FHJ82_04890 ENOG4108AEY RNA polymerase sigma factor FHJ82_04895 ENOG4105F6E Acyl-transferase FHJ82_04900 ENOG4105C37 (CBS) domain FHJ82_04910 ENOG4105CHM Aminotransferase FHJ82_04915 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase FHJ82_04920 ENOG4105C37 (CBS) domain FHJ82_04930 ENOG4105WMR Protein CrcB homolog FHJ82_04935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FHJ82_04945 ENOG4105D64 Mechanosensitive ion channel FHJ82_04950 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FHJ82_04955 ENOG4107VMI polysaccharide deacetylase FHJ82_04960 ENOG4105F0I Aminotransferase FHJ82_04965 ENOG4105W1N transcriptional regulator FHJ82_04970 ENOG4105IIP Membrane FHJ82_04980 ENOG4105BZ1 (ABC) transporter FHJ82_04985 ENOG4105BZ1 (ABC) transporter FHJ82_05010 ENOG410839P FHJ82_05020 ENOG4106MP8 UPF0754 membrane protein FHJ82_05025 ENOG4105WZB UPF0342 protein FHJ82_05030 ENOG4105F1N DNA alkylation repair FHJ82_05040 ENOG4105D4P Coproporphyrinogen iii oxidase FHJ82_05050 ENOG4107S91 Sodium hydrogen exchanger FHJ82_05055 ENOG4105NCW Trka-c domain protein FHJ82_05065 ENOG4105CGU Enoyl-CoA hydratase FHJ82_05075 ENOG4108IUX (ABC) transporter FHJ82_05080 ENOG4105RHA ABC transporter, permease FHJ82_05085 ENOG4107VRP DNA repair exonuclease FHJ82_05090 ENOG4106D4I domain protein FHJ82_05095 ENOG4105EQI Metal Dependent Phosphohydrolase FHJ82_05105 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FHJ82_05155 ENOG4105NBU tryptophan transport protein FHJ82_05160 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FHJ82_05165 ENOG4105K59 histidine triad (HIT) protein FHJ82_05195 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FHJ82_05200 ENOG4105BZ4 penicillin-binding protein FHJ82_05205 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FHJ82_05210 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FHJ82_05215 ENOG4105C1Q protoporphyrinogen oxidase FHJ82_05225 ENOG4105ECB domain protein FHJ82_05240 ENOG4105DER m42 family FHJ82_05250 ENOG4106AXD FHJ82_05255 ENOG4108RQ5 Beta-lactamase domain-containing protein FHJ82_05260 ENOG4105DF9 Lipoate-protein, ligase FHJ82_05270 ENOG4105CEY Amp-dependent synthetase and ligase FHJ82_05280 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FHJ82_05295 ENOG4108HUF Transporter FHJ82_05300 ENOG4107TB6 phosphoglycerate mutase FHJ82_05310 ENOG4107F3J Amp-dependent synthetase and ligase FHJ82_05315 ENOG4107ZYJ bioY protein FHJ82_05320 ENOG4106YBV Methyl-accepting chemotaxis FHJ82_05340 ENOG4105XVF Competence transcription factor FHJ82_05350 ENOG4108ZMX Domain of unknown function (DU1801) FHJ82_05360 ENOG4105X3H Excalibur domain protein FHJ82_05365 ENOG4105K8R UPF0145 protein FHJ82_05370 ENOG4105E1V na solute symporter FHJ82_05375 ENOG4106CAD Protein of unknown function (DUF3311) FHJ82_05380 ENOG41060YP FHJ82_05395 ENOG4107SCK Monooxygenase FHJ82_05400 ENOG4108INS Transcriptional regulator FHJ82_05405 ENOG4108KK1 membrane protein AbrB duplication FHJ82_05415 ENOG4108IG5 Transcriptional regulator FHJ82_05425 ENOG4108QY0 Membrane FHJ82_05430 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FHJ82_05435 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FHJ82_05445 ENOG4105EYH Exonuclease FHJ82_05490 ENOG4105ERH Fumarylacetoacetate hydrolase FHJ82_05510 ENOG4105CAQ asparagine synthetase FHJ82_05520 ENOG4105UQX Mate efflux family protein FHJ82_05525 ENOG4106HBX Transcriptional Regulator AraC Family FHJ82_05535 ENOG4105SF0 DinB family FHJ82_05540 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FHJ82_05545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FHJ82_05550 ENOG4105MYW Pentapeptide repeat protein FHJ82_05555 ENOG4105MA6 gCN5-related N-acetyltransferase FHJ82_05565 ENOG4108VPT UPF0234 protein FHJ82_05570 ENOG4105QNR S1 RNA binding domain protein FHJ82_05575 ENOG4105DIH basic membrane FHJ82_05580 ENOG4105C8Q Methyl-accepting chemotaxis FHJ82_05585 ENOG4107E6A Cytochrome p-450 FHJ82_05595 ENOG4105EPR degv family FHJ82_05600 ENOG4107AYK membrAne FHJ82_05610 ENOG41073B9 FHJ82_05615 ENOG4108KP7 hydrolase FHJ82_05620 ENOG4108MXZ Esterase FHJ82_05625 ENOG4105VG1 fes assembly suf system protein FHJ82_05630 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FHJ82_05635 ENOG4105IQ5 FAD linked oxidase domain protein FHJ82_05645 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FHJ82_05650 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FHJ82_05655 ENOG4105CAS nag kinase FHJ82_05660 ENOG4105C8Y Acetylornithine aminotransferase FHJ82_05665 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FHJ82_05675 ENOG4105DBV ornithine carbamoyltransferase FHJ82_05705 ENOG4107RMD Basic membrane lipoprotein FHJ82_05720 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FHJ82_05725 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FHJ82_05735 ENOG4105C3U ABC transporter FHJ82_05740 ENOG4108JQ7 (ABC) transporter FHJ82_05755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHJ82_05765 ENOG4105C31 Tryptophanyl-tRNA synthetase FHJ82_05770 ENOG4108J59 Extracellular solute-binding protein, family 5 FHJ82_05775 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FHJ82_05780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHJ82_05790 ENOG4108JQ7 (ABC) transporter FHJ82_05805 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FHJ82_05810 ENOG4108ZCF integral membrane protein FHJ82_05815 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FHJ82_05825 ENOG4105DPN Oligoendopeptidase f FHJ82_05830 ENOG4105T58 Dithiol-disulfide isomerase FHJ82_05835 ENOG4108Z18 K06886 hemoglobin FHJ82_05840 ENOG4105E4C Lytic transglycosylase catalytic FHJ82_05845 ENOG4105MIX Adenylate cyclase FHJ82_05860 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FHJ82_05865 ENOG4105EMS pseudouridine synthase FHJ82_05870 ENOG4107S1Q Phosphatase FHJ82_05885 ENOG4105ETU transcriptional activator (TenA FHJ82_05890 ENOG4108VEU Thiamine monophosphate synthase FHJ82_05910 ENOG4105D06 uba thif-type nad fad binding protein FHJ82_05915 ENOG4105DWF phosphomethylpyrimidine kinase FHJ82_05920 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FHJ82_05925 ENOG4107A88 FHJ82_05975 ENOG4105ENA helicase FHJ82_05995 ENOG4105CJ1 ABC, transporter FHJ82_06010 ENOG4108ZMI UPF0477 protein FHJ82_06020 ENOG4105C28 cystathionine FHJ82_06025 ENOG4105C28 cystathionine FHJ82_06065 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase FHJ82_06080 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHJ82_06095 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FHJ82_06100 ENOG4105CMR udp-glucose 4-epimerase FHJ82_06105 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FHJ82_06110 ENOG4105CK1 PTS System FHJ82_06115 ENOG4105VCP PTS System FHJ82_06125 ENOG4105E98 transcriptional regulator DeoR family FHJ82_06145 ENOG4105KT7 mgtC SapB transporter FHJ82_06170 ENOG4108IEG Formate dehydrogenase Alpha subunit FHJ82_06180 ENOG4106A3M Cytochrome p-450 FHJ82_06185 ENOG41087PP glycosyltransferase MGT family FHJ82_06195 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FHJ82_06200 ENOG4105C4B ABC transporter, permease FHJ82_06205 ENOG4108IXI (ABC) transporter FHJ82_06215 ENOG4105Q95 Cupin 2, conserved barrel domain protein FHJ82_06230 ENOG4105D2H Uronic isomerase FHJ82_06235 ENOG4105CT4 transporter FHJ82_06240 ENOG4107KJX Transcriptional regulator FHJ82_06245 ENOG4107QZW Altronate oxidoreductase FHJ82_06250 ENOG4105CTX dehydratase FHJ82_06260 ENOG4105F3H Histidine kinase FHJ82_06280 ENOG4105BZU Histidine kinase FHJ82_06300 ENOG4108JJA ABC, transporter FHJ82_06310 ENOG4107TSN permease FHJ82_06330 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FHJ82_06335 ENOG4105KWG Pfam:DUF1696 FHJ82_06340 ENOG4105K7W phage-related replication protein FHJ82_06345 ENOG410635T phage-like element pbsx protein FHJ82_06385 ENOG4108TFU terminase (Small subunit) FHJ82_06395 ENOG4108MDF Phage Portal Protein FHJ82_06420 ENOG41060SN FHJ82_06435 ENOG4105PQS phage protein FHJ82_06440 ENOG4105FR7 XkdM protein, phage-like element PBSX FHJ82_06445 ENOG4105MTC XkdN-like protein FHJ82_06455 ENOG4108FKH Transglycosylase SLT domain FHJ82_06455 ENOG4108FKH Transglycosylase SLT domain FHJ82_06455 ENOG4108FKH Transglycosylase SLT domain FHJ82_06460 ENOG4108WZM domain protein FHJ82_06465 ENOG4105X7F FHJ82_06475 ENOG4105MFU Protein of unknown function (DUF2634) FHJ82_06480 ENOG41066EA baseplate J family protein FHJ82_06485 ENOG410906S phage-like element pbsx protein xkdt FHJ82_06495 ENOG41068G1 FHJ82_06525 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FHJ82_06540 ENOG4105CJ3 phosphate transporter FHJ82_06545 ENOG4107GRR phosphate transport regulator FHJ82_06550 ENOG4107R7I amino acid FHJ82_06560 ENOG4105EDW glycosyl transferase, family 39 FHJ82_06565 ENOG4105CKK Glycosyl transferase, family 2 FHJ82_06570 ENOG4105C0H protease FHJ82_06580 ENOG4108ME1 Peptidase M55 D-aminopeptidase FHJ82_06585 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FHJ82_06590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHJ82_06605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FHJ82_06610 ENOG4105DTQ mandelate racemase muconate lactonizing FHJ82_06615 ENOG4107SN7 NLP P60 protein FHJ82_06620 ENOG4108JQ7 (ABC) transporter FHJ82_06625 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FHJ82_06630 ENOG4107TUM Amidinotransferase FHJ82_06635 ENOG4108S4H thioesterase Superfamily protein FHJ82_06640 ENOG4108428 Inherit from COG: -acetyltransferase FHJ82_06650 ENOG41080TC multidrug resistance protein FHJ82_06655 ENOG4105CIY formyltetrahydrofolate deformylase FHJ82_06660 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FHJ82_06675 ENOG4105K56 Transcriptional regulator FHJ82_06680 ENOG4108ZHJ Organic hydroperoxide resistance protein FHJ82_06695 ENOG4107TVC Glycosyl transferase, family 2 FHJ82_06715 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FHJ82_06720 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FHJ82_06730 ENOG4108W7F transporter, permease FHJ82_06735 ENOG4108JJB ABC transporter FHJ82_06740 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein FHJ82_06745 ENOG4105VRS hydrolase family 18 FHJ82_06765 ENOG4105CJW magnesium transporter FHJ82_06770 ENOG4105V75 Transcriptional regulator FHJ82_06800 ENOG4105FDF Could be involved in DNA repair (By similarity) FHJ82_06810 ENOG4107T5V SNARE associated Golgi FHJ82_06815 ENOG4107TS3 membrane protein, TerC FHJ82_06820 ENOG4108WZW RNA polymerase sigma FHJ82_06830 ENOG410681C small acid-soluble spore protein FHJ82_06840 ENOG4105D0M Protease HtpX homolog FHJ82_06850 ENOG410900G Protein of unknown function (DUF421) FHJ82_06860 ENOG4108TGC Acyltransferase FHJ82_06865 ENOG4105BZU Histidine kinase FHJ82_06870 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FHJ82_06875 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FHJ82_06885 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FHJ82_06895 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FHJ82_06900 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FHJ82_06905 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FHJ82_06910 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FHJ82_06920 ENOG4105BZU Histidine kinase FHJ82_06925 ENOG41090MY MarR family Transcriptional regulator FHJ82_06930 ENOG4105ER2 Ompa motb domain protein FHJ82_06935 ENOG4105E14 MotA TolQ exbB proton channel FHJ82_06950 ENOG4108K88 Membrane FHJ82_06960 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FHJ82_06965 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FHJ82_06970 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FHJ82_06975 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FHJ82_06990 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FHJ82_07015 ENOG4105F0V Cell wall hydrolase FHJ82_07030 ENOG4105C59 p-type ATPase FHJ82_07035 ENOG4105DC7 peptidase M24 FHJ82_07045 ENOG4105CID antiterminator FHJ82_07055 ENOG4105KRI phosphocarrier protein (HPr FHJ82_07060 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FHJ82_07070 ENOG4105F6S Spore photoproduct lyase FHJ82_07075 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FHJ82_07080 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FHJ82_07085 ENOG4105K4I Scp-like extracellular FHJ82_07095 ENOG4105BZU Histidine kinase FHJ82_07100 ENOG4105CHM Aminotransferase FHJ82_07115 ENOG4105UIN FHJ82_07125 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FHJ82_07145 ENOG4105EPM Diguanylate phosphodiesterase FHJ82_07155 ENOG4108XRC Protein of unknown function (DUF458) FHJ82_07185 ENOG4105NQC Flavodoxin FHJ82_07205 ENOG4105D8X mechanosensitive ion channel FHJ82_07210 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHJ82_07225 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FHJ82_07230 ENOG4105D06 uba thif-type nad fad binding protein FHJ82_07235 ENOG4105CVM Molybdenum cofactor synthesis domain protein FHJ82_07240 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FHJ82_07245 ENOG4108ZAF Molybdopterin FHJ82_07250 ENOG41067WU Molybdopterin converting factor (Subunit 1) FHJ82_07260 ENOG4107X8C Efflux transporter RND family MFP subunit FHJ82_07265 ENOG4105C19 ABC transporter FHJ82_07270 ENOG4107RBB ABC transporter, permease FHJ82_07275 ENOG4105E98 transcriptional regulator DeoR family FHJ82_07280 ENOG4105DE4 1-phosphofructokinase FHJ82_07285 ENOG4105DM4 PTS System FHJ82_07300 ENOG4105C5H ABC transporter FHJ82_07305 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FHJ82_07335 ENOG4105BZU Histidine kinase FHJ82_07345 ENOG4107ZYR domain protein FHJ82_07350 ENOG4105CPN adenine deaminase FHJ82_07355 ENOG4105CN5 Metallo-Beta-Lactamase FHJ82_07360 ENOG4106148 UPF0356 protein FHJ82_07365 ENOG4108X4Q Hydrolase FHJ82_07370 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FHJ82_07390 ENOG4107QKG PfaD family FHJ82_07395 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_07400 ENOG4107SQU synthase FHJ82_07405 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_07410 ENOG4107SQU synthase FHJ82_07415 ENOG4107SQU synthase FHJ82_07420 ENOG4107SQU synthase FHJ82_07430 ENOG4105FQP Beta-lactamase FHJ82_07440 ENOG4105CPP Dehydrogenase, E1 component FHJ82_07445 ENOG4105C7S Dehydrogenase FHJ82_07470 ENOG4105CXN decarboxylase FHJ82_07475 ENOG4105WBI UPF0223 protein FHJ82_07495 ENOG4105ECY inositol monophosphatase FHJ82_07505 ENOG4105D4Y metalloprotease FHJ82_07530 ENOG4105CI3 gtp-binding protein typa FHJ82_07535 ENOG4105QA2 FHJ82_07550 ENOG4108IAB Phoh family FHJ82_07560 ENOG4105CSV Glutaminase FHJ82_07570 ENOG4105CNI cell division protein FtsW FHJ82_07575 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FHJ82_07585 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FHJ82_07595 ENOG4105BZ9 Cytochrome C oxidase, subunit I FHJ82_07600 ENOG4105CCU oxidase (Subunit III) FHJ82_07605 ENOG41064X9 cytochrome C oxidase subunit IV FHJ82_07620 ENOG41080XQ Signal transduction protein with cbs domains FHJ82_07625 ENOG4106UY4 Inherit from COG: Scp-like extracellular FHJ82_07650 ENOG4106H78 methyltransferase FHJ82_07655 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FHJ82_07660 ENOG4105H20 Sporulation integral membrane protein YlbJ FHJ82_07665 ENOG4105D78 K07001 NTE family protein FHJ82_07670 ENOG41063PX domain protein FHJ82_07680 ENOG4105KNH Nucleic acid-binding protein FHJ82_07710 ENOG4108V6E Cell division protein mraZ FHJ82_07715 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FHJ82_07725 ENOG4105CJN penicillin-binding protein FHJ82_07730 ENOG4105CJN penicillin-binding protein FHJ82_07735 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FHJ82_07740 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FHJ82_07745 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FHJ82_07750 ENOG4105CNI cell division protein FtsW FHJ82_07755 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FHJ82_07760 ENOG4105D4A Cell wall formation (By similarity) FHJ82_07765 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FHJ82_07770 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FHJ82_07775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FHJ82_07785 ENOG4105FFI sigma-e processing peptidase spoiiga FHJ82_07790 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHJ82_07800 ENOG4105DKW ABC transporter FHJ82_07810 ENOG4105WR5 sporulation protein, YlmC YmxH family FHJ82_07815 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FHJ82_07820 ENOG4105DFA alanine racemase domain protein FHJ82_07825 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FHJ82_07830 ENOG41067XK integral membrane protein FHJ82_07835 ENOG4105DBK s4 domain protein FHJ82_07850 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FHJ82_07860 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FHJ82_07865 ENOG4105C34 Pseudouridine synthase FHJ82_07870 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FHJ82_07880 ENOG4105CXT aspartate transcarbamylase FHJ82_07890 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FHJ82_07895 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FHJ82_07900 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FHJ82_07905 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FHJ82_07915 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FHJ82_07930 ENOG4107RIQ Sulfate adenylate transferase FHJ82_07940 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FHJ82_07950 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FHJ82_07970 ENOG4105DSJ YicC domain protein FHJ82_07975 ENOG4105KC4 UPF0296 protein FHJ82_07980 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FHJ82_07990 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FHJ82_07995 ENOG4105C25 Primosomal protein n' FHJ82_08000 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FHJ82_08005 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FHJ82_08010 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FHJ82_08015 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FHJ82_08020 ENOG4108ZF3 Phosphatase FHJ82_08025 ENOG4105D9P serine threonine protein kinase FHJ82_08030 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FHJ82_08035 ENOG4105DJV ribulose-phosphate 3-epimerase FHJ82_08040 ENOG4105FJ0 thiamine FHJ82_08050 ENOG4105VB9 50S ribosomal protein l28 FHJ82_08055 ENOG4108ZAA Alkaline-shock protein FHJ82_08060 ENOG4105DP4 dak2 domain fusion protein ylov FHJ82_08070 ENOG4105EJQ L-serine dehydratase FHJ82_08075 ENOG4105CB5 ATP-dependent DNA helicase recG FHJ82_08080 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FHJ82_08085 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FHJ82_08090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FHJ82_08095 ENOG4105CHR reductase FHJ82_08105 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FHJ82_08110 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FHJ82_08115 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FHJ82_08125 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FHJ82_08135 ENOG4105K5M 30s ribosomal protein S16 FHJ82_08140 ENOG4108BW8 UPF0109 protein FHJ82_08155 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FHJ82_08160 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FHJ82_08165 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FHJ82_08170 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FHJ82_08180 ENOG4105VM1 flagellar FHJ82_08185 ENOG4105CMV Succinyl-CoA synthetase subunit beta FHJ82_08190 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FHJ82_08195 ENOG4105C79 DNA protecting protein DprA FHJ82_08200 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FHJ82_08205 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FHJ82_08210 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHJ82_08215 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FHJ82_08220 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FHJ82_08230 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FHJ82_08235 ENOG4108ZC9 flagellar basal-body rod protein flgc FHJ82_08240 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FHJ82_08245 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FHJ82_08250 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FHJ82_08265 ENOG4106YF4 Flagellar biosynthesis chaperone FHJ82_08275 ENOG410696Y Flagellar hook-length control protein FHJ82_08280 ENOG410822I Flagellar hook capping protein FHJ82_08285 ENOG4108JQA flagellar FHJ82_08290 ENOG41068WV flagellar FlbD family protein FHJ82_08300 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FHJ82_08305 ENOG4105DD5 Flagellar motor switch protein FHJ82_08310 ENOG4107YTP response regulator receiver protein FHJ82_08320 ENOG4105CN7 Flagellar biosynthetic protein FliP FHJ82_08325 ENOG4105VS8 Flagellar biosynthetic protein fliq FHJ82_08330 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FHJ82_08335 ENOG4105D00 flagellar biosynthetic protein flhB FHJ82_08340 ENOG4105D7B Flagellar biosynthesis protein flha FHJ82_08345 ENOG4105FZW flagellar biosynthesis regulator FlhF FHJ82_08355 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FHJ82_08360 ENOG4105CBS Chea signal transduction histidine kinase FHJ82_08365 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FHJ82_08375 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FHJ82_08380 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHJ82_08390 ENOG4105CE9 30S ribosomal protein S2 FHJ82_08400 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FHJ82_08405 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FHJ82_08410 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FHJ82_08415 ENOG4105KNE Phosphatidate cytidylyltransferase FHJ82_08425 ENOG4105DZP Membrane-associated zinc metalloprotease FHJ82_08430 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FHJ82_08435 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FHJ82_08440 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FHJ82_08445 ENOG4105CHV Transcription elongation factor NusA FHJ82_08450 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FHJ82_08455 ENOG4105VHM ribosomal protein FHJ82_08460 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FHJ82_08465 ENOG4105W7A Protein of unknown function (DUF503) FHJ82_08470 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FHJ82_08475 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FHJ82_08480 ENOG4105DTN riboflavin biosynthesis protein ribF FHJ82_08485 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FHJ82_08490 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FHJ82_08500 ENOG4105C1V Peptidase, M16 FHJ82_08510 ENOG4105E35 Dipicolinate synthase subunit A FHJ82_08515 ENOG4108S0H Dipicolinic acid synthetase, b subunit FHJ82_08520 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FHJ82_08530 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FHJ82_08540 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FHJ82_08550 ENOG4105CNU cell division protein FtsK FHJ82_08555 ENOG4105FDP GntR family transcriptional regulator FHJ82_08570 ENOG4105EYF MMPL domain protein FHJ82_08585 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FHJ82_08590 ENOG4105XZV Protein of unknown function (DUF3243) FHJ82_08605 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FHJ82_08610 ENOG4105CEV competence damage-inducible protein FHJ82_08615 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FHJ82_08620 ENOG4108A04 Beta-lactamase FHJ82_08630 ENOG4105D48 metallophosphoesterase FHJ82_08635 ENOG4105MCT stage V sporulation protein S FHJ82_08640 ENOG4105CPQ Dehydrogenase FHJ82_08645 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FHJ82_08650 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FHJ82_08670 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FHJ82_08680 ENOG4108151 Beta-lactamase domain protein FHJ82_08685 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FHJ82_08690 ENOG4108JA1 polyketide synthase FHJ82_08695 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FHJ82_08700 ENOG41062T2 Acyl carrier protein FHJ82_08705 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FHJ82_08710 ENOG4108MGH Enoyl-CoA hydratase FHJ82_08715 ENOG4108KQ6 Enoyl-CoA hydratase FHJ82_08720 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_08725 ENOG4107SQU synthase FHJ82_08735 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_08745 ENOG4106A3M Cytochrome p-450 FHJ82_08750 ENOG4105WFK nuclease FHJ82_08755 ENOG4105XPP Protein of unknown function (DUF1275) FHJ82_08765 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FHJ82_08775 ENOG4105K7W phage-related replication protein FHJ82_08780 ENOG4108X3M OsmC Ohr family protein FHJ82_08805 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FHJ82_08830 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FHJ82_08835 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FHJ82_08840 ENOG4105U6W MutT NUDIX family protein FHJ82_08845 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FHJ82_08855 ENOG4106F1P AAA ATPase, central domain protein FHJ82_08860 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FHJ82_08865 ENOG4105CXI aluminum resistance protein FHJ82_08870 ENOG4105KV4 Transcriptional regulator FHJ82_08875 ENOG4105C5F glutamine synthetase FHJ82_08900 ENOG41064BW Protein of unknown function (DUF2568) FHJ82_08920 ENOG4105CT4 transporter FHJ82_08935 ENOG4105C93 Xylose Isomerase FHJ82_08940 ENOG4105CMG Carbohydrate kinase FHJ82_08945 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FHJ82_08975 ENOG4105DQ4 alcohol dehydrogenase FHJ82_08980 ENOG4105MXK Carbon dioxide concentrating mechanism protein FHJ82_09030 ENOG4108M1A Chitin-binding protein FHJ82_09050 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FHJ82_09060 ENOG4105K7W phage-related replication protein FHJ82_09080 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FHJ82_09095 ENOG4105VPS UPF0291 protein FHJ82_09100 ENOG4105CV1 Transketolase (EC 2.2.1.1) FHJ82_09110 ENOG4105VXM UPF0154 protein FHJ82_09120 ENOG4107QIV Cytochrome c biogenesis protein FHJ82_09155 ENOG4108I0Z Aconitate hydratase FHJ82_09160 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHJ82_09175 ENOG41067CD Small, acid-soluble spore protein Tlp FHJ82_09185 ENOG4105MI2 FHJ82_09190 ENOG4105W8X HesB YadR YfhF-family protein FHJ82_09195 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FHJ82_09200 ENOG4105K4P CoA-binding domain protein FHJ82_09205 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHJ82_09230 ENOG4105CPQ Dehydrogenase FHJ82_09235 ENOG4108UHU Aldolase FHJ82_09240 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FHJ82_09245 ENOG4105DMW Dehydrogenase reductase FHJ82_09255 ENOG4108I5G Major Facilitator superfamily FHJ82_09270 ENOG4105FVX FHJ82_09315 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHJ82_09325 ENOG4107SYN Glycosyl hydrolases family 43 FHJ82_09350 ENOG4105DTD Dehydrogenase FHJ82_09355 ENOG4108IIH CoA-transferase subunit B FHJ82_09360 ENOG4105D6N CoA-transferase, subunit a FHJ82_09365 ENOG4105CY2 Citrate transporter FHJ82_09370 ENOG4106A3M Cytochrome p-450 FHJ82_09375 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FHJ82_09380 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FHJ82_09385 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FHJ82_09390 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FHJ82_09395 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) FHJ82_09410 ENOG4107T5V SNARE associated Golgi FHJ82_09415 ENOG4107QX3 carboxylase FHJ82_09420 ENOG4105E39 Enoyl-CoA hydratase FHJ82_09425 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FHJ82_09430 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FHJ82_09435 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FHJ82_09440 ENOG4105CEY Amp-dependent synthetase and ligase FHJ82_09445 ENOG4105C1G acyl-Coa dehydrogenase FHJ82_09450 ENOG4105F32 YngK protein FHJ82_09455 ENOG4106U2H Protein of unknown function (DUF1360) FHJ82_09470 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_09480 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_09490 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FHJ82_09495 ENOG4108N2V aldose 1-epimerase FHJ82_09500 ENOG4107QJQ Mate efflux family protein FHJ82_09525 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FHJ82_09530 ENOG4108RWP Major Facilitator Superfamily protein FHJ82_09535 ENOG4105WAB arsR family transcriptional regulator FHJ82_09540 ENOG4105C22 threonyL-tRNA synthetase FHJ82_09545 ENOG4108KSA LysR family transcriptional regulator FHJ82_09550 ENOG4105CB2 alcohol dehydrogenase FHJ82_09555 ENOG4105BZ8 glutamate synthase FHJ82_09560 ENOG4105CBC glutamate synthase FHJ82_09565 ENOG4105C5Q Transcriptional regulator FHJ82_09570 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FHJ82_09595 ENOG4108UB7 FHJ82_09600 ENOG4105IE8 Alpha-ketoglutarate permease FHJ82_09605 ENOG4107U6E carbohydrate kinase FGGY FHJ82_09610 ENOG4108M3J Dehydrogenase FHJ82_09615 ENOG4108J2R molybdopterin oxidoreductase FHJ82_09640 ENOG4106ANW SMI1_KNR4 FHJ82_09645 ENOG4106BHF FHJ82_09650 ENOG4108Z7R Chaperone CsaA FHJ82_09655 ENOG4105FTV AraC Family Transcriptional Regulator FHJ82_09665 ENOG4108W8B Beta-lactamase domain protein FHJ82_09675 ENOG4105KTU Transcriptional regulator, arsr family FHJ82_09685 ENOG4108SJC Membrane FHJ82_09710 ENOG41069ER domain protein FHJ82_09715 ENOG4105C9U ATP-dependent DNA helicase RecQ FHJ82_09725 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FHJ82_09730 ENOG4105SCY DNAK suppressor FHJ82_09775 ENOG4105C26 Dehydrogenase FHJ82_09780 ENOG4105EWU Squalene--hopene cyclase FHJ82_09785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FHJ82_09790 ENOG4105C8J )-transporter FHJ82_09795 ENOG4105C09 Bile acid FHJ82_09805 ENOG4105C7S Dehydrogenase FHJ82_09810 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FHJ82_09815 ENOG4107T89 von Willebrand factor, type A FHJ82_09820 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FHJ82_09830 ENOG4105K4H Nlp p60 protein FHJ82_09835 ENOG41087PP glycosyltransferase MGT family FHJ82_09845 ENOG4107QMU Mate efflux family protein FHJ82_09850 ENOG4106SCS STAS domain FHJ82_09870 ENOG4105FR1 rard protein FHJ82_09885 ENOG41090U3 tautomerase FHJ82_09905 ENOG4105FBA Phospholipase Carboxylesterase FHJ82_09920 ENOG4105E1V na solute symporter FHJ82_09930 ENOG4105CS2 ec 3.2.1.21 FHJ82_09935 ENOG4108S3Y transcriptional regulator FHJ82_09955 ENOG4108VXD carboxy-peptidase FHJ82_09960 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FHJ82_09970 ENOG4106Z5R FHJ82_09975 ENOG410841Q phosphoesterase PA-phosphatase related protein FHJ82_10000 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FHJ82_10005 ENOG4108TSC N-acetyltransferase FHJ82_10010 ENOG4107S4Y M20 DapE family protein YgeY FHJ82_10025 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FHJ82_10030 ENOG4105FTQ Dna gyrase FHJ82_10140 ENOG4106ANW SMI1_KNR4 FHJ82_10145 ENOG4106BHF FHJ82_10155 ENOG4107Y9E nuclease FHJ82_10170 ENOG4105E0X reductase FHJ82_10175 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FHJ82_10185 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) FHJ82_10190 ENOG41090WU lipolytic protein G-D-S-L family FHJ82_10195 ENOG4108KF3 Electron transport protein SCO1 SenC FHJ82_10205 ENOG4105C7B Threonine dehydratase FHJ82_10215 ENOG4108UT2 hemolysin iii FHJ82_10225 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FHJ82_10230 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FHJ82_10240 ENOG4107YX5 Pfam:DUF548 FHJ82_10245 ENOG4108Y6J UPF0403 protein FHJ82_10250 ENOG4105C01 Dihydroxy-acid dehydratase FHJ82_10265 ENOG4108V06 Glutathione peroxidase FHJ82_10270 ENOG4105CVG Homoserine O-transsuccinylase FHJ82_10315 ENOG41081VK Ribonuclease FHJ82_10340 ENOG410890F Dynamin family FHJ82_10355 ENOG41065KQ synthase FHJ82_10385 ENOG4105C2W permease FHJ82_10390 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FHJ82_10395 ENOG4105CTD carboxy-peptidase FHJ82_10400 ENOG4105DVT helicase FHJ82_10415 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FHJ82_10425 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FHJ82_10430 ENOG4108UKS UPF0398 protein FHJ82_10445 ENOG4107X2U Inherit from COG: Exonuclease-like protein FHJ82_10450 ENOG4108I5C dEAD DEAH box helicase FHJ82_10495 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FHJ82_10500 ENOG4105BZ4 penicillin-binding protein FHJ82_10510 ENOG4105CSM endonuclease III FHJ82_10520 ENOG4105C5S asparaginyl-tRNA synthetase FHJ82_10525 ENOG4105CHM Aminotransferase FHJ82_10535 ENOG4105YAC FHJ82_10540 ENOG4105DVT helicase FHJ82_10545 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FHJ82_10555 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FHJ82_10565 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FHJ82_10570 ENOG4105CPK Glycosyl transferase (Group 1 FHJ82_10575 ENOG4105FJR Lmbe family FHJ82_10580 ENOG4108Z5K methylglyoxal synthase FHJ82_10585 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FHJ82_10590 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FHJ82_10595 ENOG4108JYZ YitT family FHJ82_10620 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FHJ82_10640 ENOG41068YB TPR repeat-containing protein FHJ82_10645 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FHJ82_10655 ENOG4105CIH Imidazole acetol-phosphate transaminase FHJ82_10665 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FHJ82_10670 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FHJ82_10675 ENOG4105DK0 Indole-3-glycerol phosphate synthase FHJ82_10685 ENOG4105CRQ synthase (Component I) FHJ82_10690 ENOG4105KHN chorismate mutase FHJ82_10700 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FHJ82_10705 ENOG4105BZU Histidine kinase FHJ82_10710 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FHJ82_10715 ENOG4105EAH synthase FHJ82_10720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FHJ82_10725 ENOG4105XXQ heptaprenyl diphosphate synthase component I FHJ82_10730 ENOG4105WP2 Tryptophan RNA-binding attenuator protein FHJ82_10735 ENOG4105EUJ GTP cyclohydrolase i FHJ82_10740 ENOG4105K70 DNA-binding protein FHJ82_10745 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FHJ82_10760 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FHJ82_10765 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FHJ82_10785 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FHJ82_10790 ENOG4105CAT Cytidine monophosphate kinase FHJ82_10800 ENOG4105MSI germination protein ypeb FHJ82_10810 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) FHJ82_10815 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FHJ82_10830 ENOG4107RGJ metallophosphoesterase FHJ82_10845 ENOG4105I7S Abortive infection protein FHJ82_10850 ENOG4105C9U ATP-dependent DNA helicase RecQ FHJ82_10855 ENOG4105T7X FHJ82_10865 ENOG4108SAX Membrane FHJ82_10870 ENOG4108JQ1 Dehydrogenase FHJ82_10885 ENOG4105BZU Histidine kinase FHJ82_10890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHJ82_10895 ENOG4105CRE cytochrome C FHJ82_10900 ENOG4107TWT Cytochrome c biogenesis protein FHJ82_10910 ENOG4105FE9 pseudouridine synthase FHJ82_10920 ENOG4108JIC nucleoside recognition domain protein FHJ82_10925 ENOG4105DZ1 carboxypeptidase FHJ82_10935 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FHJ82_10940 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FHJ82_10965 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FHJ82_10970 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FHJ82_10975 ENOG4108R6K riboflavin synthase, subunit alpha FHJ82_11000 ENOG4107ZE5 PPIases accelerate the folding of proteins FHJ82_11005 ENOG4105PTM secreted protein FHJ82_11010 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FHJ82_11020 ENOG4105G6R Stage v sporulation protein ae FHJ82_11030 ENOG4105CZ3 stage V sporulation protein ad FHJ82_11035 ENOG41090VF Stage v sporulation protein ac FHJ82_11050 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHJ82_11055 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FHJ82_11060 ENOG41082AN stage II sporulation protein FHJ82_11065 ENOG4105DZ1 carboxypeptidase FHJ82_11070 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FHJ82_11075 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FHJ82_11080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHJ82_11090 ENOG4105I3K Ferric uptake regulator, Fur family FHJ82_11095 ENOG4105MZ9 stage II sporulation protein m FHJ82_11115 ENOG4105DFD Na H antiporter FHJ82_11125 ENOG4105HDK L-asparaginase FHJ82_11130 ENOG4108IMY Transcriptional regulator FHJ82_11140 ENOG4108YZ4 nudix hydrolase FHJ82_11150 ENOG4105CPC Aldo Keto reductase FHJ82_11170 ENOG4106HZJ FHJ82_11175 ENOG4105RHY Pfam:UPF0157 FHJ82_11180 ENOG4105KAC Antibiotic biosynthesis monooxygenase FHJ82_11185 ENOG4108XET gCN5-related N-acetyltransferase FHJ82_11190 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FHJ82_11205 ENOG4105C02 permease FHJ82_11215 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FHJ82_11220 ENOG4105CS9 pantothenic acid kinase FHJ82_11230 ENOG4108IXY short-chain dehydrogenase reductase FHJ82_11235 ENOG41069FQ Metallo-beta-lactamase superfamily FHJ82_11240 ENOG4105II7 pyrroline-5-carboxylate reductase FHJ82_11245 ENOG4108KQ6 Enoyl-CoA hydratase FHJ82_11250 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FHJ82_11255 ENOG4106A3M Cytochrome p-450 FHJ82_11270 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_11275 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_11285 ENOG4105C0W non-ribosomal peptide synthetase FHJ82_11295 ENOG4105CHR reductase FHJ82_11300 ENOG4105CEY Amp-dependent synthetase and ligase FHJ82_11315 ENOG4107QKG PfaD family FHJ82_11325 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FHJ82_11335 ENOG4108K70 Transcriptional regulator FHJ82_11345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FHJ82_11355 ENOG410861F 50S ribosomal protein L33 FHJ82_11360 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FHJ82_11365 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FHJ82_11370 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FHJ82_11375 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FHJ82_11385 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) FHJ82_11390 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FHJ82_11395 ENOG4108HNZ carboxyl transferase FHJ82_11400 ENOG4108ZVT methylmalonyl-coA epimerase FHJ82_11410 ENOG4108QEG Membrane FHJ82_11415 ENOG4105CDA abc transporter atp-binding protein FHJ82_11420 ENOG4105E5Q amino acid AbC transporter FHJ82_11425 ENOG4108HW3 (ABC) transporter FHJ82_11430 ENOG4108Y6J UPF0403 protein FHJ82_11435 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FHJ82_11440 ENOG4105C7S Dehydrogenase FHJ82_11445 ENOG4105CPP Dehydrogenase, E1 component FHJ82_11460 ENOG4105CKM Branched-chain carboxylic acid kinase FHJ82_11465 ENOG4107RDP Dehydrogenase FHJ82_11475 ENOG4108JUB Transcriptional regulator FHJ82_11480 ENOG4106CCJ Protein of unknown function (DUF2627) FHJ82_11485 ENOG4105CR4 methylisocitrate lyase FHJ82_11490 ENOG4105DXD 2-methylcitrate dehydratase FHJ82_11500 ENOG4105C1G acyl-Coa dehydrogenase FHJ82_11505 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FHJ82_11515 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FHJ82_11520 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FHJ82_11545 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FHJ82_11560 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FHJ82_11565 ENOG4107QQR Sporulation FHJ82_11570 ENOG4105S1Z Stage IV sporulation protein B FHJ82_11575 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FHJ82_11580 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FHJ82_11585 ENOG4105DX0 Hemolysin A FHJ82_11590 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FHJ82_11595 ENOG4105CTB Polyprenyl synthetase FHJ82_11600 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FHJ82_11605 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FHJ82_11610 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FHJ82_11615 ENOG4105M7K Involved in the transcription termination process (By similarity) FHJ82_11620 ENOG4108ZSR alkaline shock protein FHJ82_11625 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FHJ82_11645 ENOG410644B Stage III sporulation protein af FHJ82_11655 ENOG4105KQ4 Stage iii sporulation protein ad FHJ82_11660 ENOG4108CQH stage III sporulation protein AC FHJ82_11665 ENOG4105KR5 Stage iii sporulation protein FHJ82_11670 ENOG4105CD2 stage iii sporulation protein aa FHJ82_11680 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FHJ82_11685 ENOG4105DC7 peptidase M24 FHJ82_11695 ENOG4105CBJ Metal-dependent enzyme FHJ82_11715 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FHJ82_11720 ENOG4105WZW rhodanese family FHJ82_11725 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FHJ82_11735 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FHJ82_11740 ENOG4105C0D helicase FHJ82_11755 ENOG4108IMY Transcriptional regulator FHJ82_11765 ENOG4105VFR signal peptidase FHJ82_11825 ENOG4105C37 (CBS) domain FHJ82_11850 ENOG4105C5X domain protein FHJ82_11895 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FHJ82_11910 ENOG41068DG YceG-like family FHJ82_11915 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FHJ82_11920 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FHJ82_11925 ENOG4105E2Z phosphate ABC transporter (Permease FHJ82_11930 ENOG4105C8U phosphate abc transporter FHJ82_11935 ENOG4105CVA phosphate FHJ82_11940 ENOG4107RF6 penicillin-binding protein FHJ82_11950 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FHJ82_11955 ENOG4105SXS Protein of unknown function (DUF456) FHJ82_11970 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FHJ82_11975 ENOG41063Y9 FHJ82_11980 ENOG4108U5J '-nucleotidase FHJ82_11985 ENOG4105N80 Ferric uptake regulator, Fur family FHJ82_11990 ENOG4108JYZ YitT family FHJ82_11995 ENOG41069ZM Protein of unknown function (DUF2624) FHJ82_12000 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FHJ82_12015 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FHJ82_12020 ENOG4105EGD dinuclear metal center protein, YbgI family FHJ82_12035 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHJ82_12040 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FHJ82_12045 ENOG4108UPT UPF0178 protein FHJ82_12050 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FHJ82_12060 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FHJ82_12065 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FHJ82_12070 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FHJ82_12080 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FHJ82_12085 ENOG4105KG3 cytidine deaminase FHJ82_12090 ENOG4107YR5 Diacylglycerol kinase FHJ82_12095 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FHJ82_12100 ENOG4105CTJ Metal Dependent Phosphohydrolase FHJ82_12105 ENOG4105C9A Phoh family FHJ82_12110 ENOG4105EI1 sporulation protein yqfd FHJ82_12115 ENOG41068P3 sporulation protein YqfC FHJ82_12125 ENOG4105DI5 UPF0365 protein FHJ82_12130 ENOG4105F7J membrane-bound serine protease FHJ82_12135 ENOG4105KTH gatB Yqey FHJ82_12150 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FHJ82_12155 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FHJ82_12160 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FHJ82_12165 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FHJ82_12170 ENOG4105CFG Acts as a chaperone (By similarity) FHJ82_12175 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FHJ82_12180 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FHJ82_12185 ENOG4105CSA Coproporphyrinogen iii oxidase FHJ82_12190 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FHJ82_12200 ENOG4108ZRV stage ii sporulation protein p FHJ82_12205 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) FHJ82_12210 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FHJ82_12215 ENOG4105TQK DNA polymerase iii, delta' subunit FHJ82_12230 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FHJ82_12235 ENOG4108UK2 deaminase FHJ82_12240 ENOG4105KQC Competence protein FHJ82_12250 ENOG4108D32 Methyltransferase FHJ82_12260 ENOG4108WF2 Metal Dependent Phosphohydrolase FHJ82_12265 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FHJ82_12270 ENOG410812S Rna-binding protein FHJ82_12275 ENOG4105E2X shikimate dehydrogenase FHJ82_12280 ENOG4105CQW ribosome biogenesis GTPase YqeH FHJ82_12285 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FHJ82_12305 ENOG41080BT SNARE associated Golgi FHJ82_12320 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHJ82_12340 ENOG4105KVH Transcriptional regulator FHJ82_12415 ENOG4108SWU Histidine kinase FHJ82_12420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHJ82_12425 ENOG4105DHF Membrane FHJ82_12435 ENOG4108UYN gCN5-related N-acetyltransferase FHJ82_12440 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FHJ82_12450 ENOG4108J8C transporter major facilitator family protein FHJ82_12460 ENOG4108U7W acetyltransferase FHJ82_12475 ENOG4108HCJ Hydrolase FHJ82_12480 ENOG4108HCJ Hydrolase FHJ82_12490 ENOG4105DG6 mannose-6-phosphate isomerase FHJ82_12495 ENOG4105DM4 PTS System FHJ82_12510 ENOG4108Z66 YbaK ebsC protein FHJ82_12515 ENOG4107RSM transcriptional regulator FHJ82_12520 ENOG4105D94 Major Facilitator Superfamily FHJ82_12525 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FHJ82_12530 ENOG41082JN Transcriptional regulator FHJ82_12550 ENOG4105TMB Formate nitrite transporter FHJ82_12555 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FHJ82_12560 ENOG4108JB9 formate dehydrogenase FHJ82_12575 ENOG4105C28 cystathionine FHJ82_12605 ENOG4107XRG penicillin-binding protein FHJ82_12610 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FHJ82_12620 ENOG4105CFP Peptidase U32 FHJ82_12625 ENOG4105XYU peptidase (U32 family) FHJ82_12635 ENOG4105HHA aminodeoxychorismate lyase FHJ82_12645 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FHJ82_12650 ENOG4105VBH UPF0297 protein FHJ82_12655 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FHJ82_12660 ENOG4105C02 permease FHJ82_12665 ENOG4105CDA abc transporter atp-binding protein FHJ82_12670 ENOG4105CT1 (ABC) transporter FHJ82_12675 ENOG4105EAD ABC transporter FHJ82_12680 ENOG4105DRP amino acid AbC transporter FHJ82_12690 ENOG41060CR FHJ82_12700 ENOG4105C7H Helicase, RecD TraA family FHJ82_12710 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FHJ82_12715 ENOG4105C3J Cysteine desulfurase FHJ82_12725 ENOG4105D1H recombination factor protein RarA FHJ82_12730 ENOG4105CUZ uba thif-type nad fad binding protein FHJ82_12740 ENOG4105C9M aspartyl-trna synthetase FHJ82_12745 ENOG4105CUT histidyl-tRNA synthetase FHJ82_12775 ENOG41067VP Protein of unknown function (DUF1049) FHJ82_12780 ENOG4105NCW Trka-c domain protein FHJ82_12795 ENOG4105CKP Polysaccharide Biosynthesis Protein FHJ82_12800 ENOG4108QG2 Membrane FHJ82_12805 ENOG4105NAP FHJ82_12810 ENOG4105VIE preprotein translocase, subunit YajC FHJ82_12815 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FHJ82_12820 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FHJ82_12825 ENOG41061AI Protein of unknown function (DUF2905) FHJ82_12830 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FHJ82_12835 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FHJ82_12850 ENOG4106678 morphogenetic protein associated with SpoVID FHJ82_12855 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FHJ82_12860 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FHJ82_12865 ENOG4108IYU L-aspartate oxidase FHJ82_12880 ENOG4105CQC Prephenate dehydratase FHJ82_12890 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FHJ82_12900 ENOG4105K46 50S ribosomal protein l27 FHJ82_12905 ENOG4105X36 (ribosomal) protein FHJ82_12910 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FHJ82_12925 ENOG4107QMS site-determining protein FHJ82_12930 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FHJ82_12935 ENOG4105YHC Rod shape-determining protein MreD FHJ82_12950 ENOG4105W5Q DNA repair protein (RadC FHJ82_12955 ENOG4108Z03 MAF-like protein FHJ82_12965 ENOG4106A3R peptidase FHJ82_12970 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FHJ82_12975 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FHJ82_12985 ENOG4106AR7 Spore coat protein FHJ82_12990 ENOG41068KH stage VI sporulation protein D FHJ82_12995 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FHJ82_13000 ENOG4105D52 delta-aminolevulinic acid dehydratase FHJ82_13010 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FHJ82_13020 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FHJ82_13030 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FHJ82_13035 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FHJ82_13040 ENOG4108IUQ atp-dependent protease FHJ82_13045 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FHJ82_13050 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FHJ82_13060 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FHJ82_13065 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FHJ82_13070 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FHJ82_13080 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FHJ82_13085 ENOG4108ZP8 Acetolactate synthase small subunit FHJ82_13090 ENOG4105C7K acetolactate synthase FHJ82_13115 ENOG4105M59 Phosphodiesterase, mj0936 family FHJ82_13120 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FHJ82_13125 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FHJ82_13130 ENOG4108XJQ germination protein FHJ82_13135 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FHJ82_13140 ENOG41067TZ transcriptional regulator, MarR family FHJ82_13145 ENOG4105PFC Transcriptional regulator FHJ82_13155 ENOG4105E33 succinate dehydrogenase FHJ82_13165 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FHJ82_13175 ENOG4105CFH Aspartokinase FHJ82_13185 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FHJ82_13190 ENOG4105K63 Thioredoxin FHJ82_13195 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FHJ82_13200 ENOG4105C10 Electron transfer flavoprotein FHJ82_13205 ENOG4105BZJ Electron transfer flavoprotein FHJ82_13210 ENOG41060WC Enoyl-CoA hydratase FHJ82_13215 ENOG4107Z3H Transcriptional regulator, TetR family FHJ82_13220 ENOG4105CEY Amp-dependent synthetase and ligase FHJ82_13235 ENOG4105C98 muts2 protein FHJ82_13240 ENOG4105DCG PHP domain protein FHJ82_13255 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FHJ82_13265 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FHJ82_13270 ENOG4108RWN rrna methyltransferase FHJ82_13275 ENOG41067MF small acid-soluble spore protein FHJ82_13285 ENOG4105CQB FAD linked oxidase domain protein FHJ82_13300 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FHJ82_13305 ENOG4105DRS transport system, permease FHJ82_13320 ENOG4108MDK Dehydrogenase FHJ82_13330 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FHJ82_13335 ENOG4105EF1 ribulokinase FHJ82_13345 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FHJ82_13350 ENOG4105CN9 Peptidase m42 family protein FHJ82_13360 ENOG410696E Membrane FHJ82_13365 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FHJ82_13370 ENOG4105VJV 50s ribosomal protein L35 FHJ82_13375 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FHJ82_13380 ENOG41067MG lrgb family FHJ82_13390 ENOG4105DY9 regulatoR FHJ82_13395 ENOG4108HRK Histidine kinase FHJ82_13405 ENOG4105C22 threonyL-tRNA synthetase FHJ82_13410 ENOG4108TDW sporulation protein YtxC FHJ82_13435 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FHJ82_13440 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FHJ82_13445 ENOG4105KVH Transcriptional regulator FHJ82_13450 ENOG4105F27 Major Facilitator FHJ82_13455 ENOG4105CV8 reductase FHJ82_13460 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FHJ82_13470 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FHJ82_13475 ENOG4105C2M dna polymerase I FHJ82_13480 ENOG4105BZU Histidine kinase FHJ82_13485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHJ82_13495 ENOG4108HMX isocitrate dehydrogenase (NADP) FHJ82_13500 ENOG4105BZN citrate synthase FHJ82_13515 ENOG4105G7B Protein of unknown function (DUF2992) FHJ82_13525 ENOG4108REF Sporulation integral membrane protein ytvi FHJ82_13530 ENOG4105FS0 cytoplasmic membrane protein FHJ82_13535 ENOG4105CA9 Pyruvate kinase FHJ82_13540 ENOG4105CTQ phosphohexokinase FHJ82_13545 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FHJ82_13550 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FHJ82_13555 ENOG4105C6K Malic enzyme FHJ82_13560 ENOG4105C0B DNA polymerase III (alpha subunit) FHJ82_13565 ENOG4105VV2 FHJ82_13575 ENOG4106EVM FHJ82_13615 ENOG4105EPU Molybdenum cofactor synthesis domain protein FHJ82_13630 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FHJ82_13635 ENOG4105KBJ sporulation protein ytfj FHJ82_13645 ENOG4105VK3 rdd domain containing protein FHJ82_13650 ENOG4105D07 Signal peptide peptidase, SppA FHJ82_13655 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FHJ82_13660 ENOG4105EFZ amidohydrolase FHJ82_13665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FHJ82_13675 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FHJ82_13710 ENOG4105BZU Histidine kinase FHJ82_13720 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FHJ82_13725 ENOG4105C26 Dehydrogenase FHJ82_13780 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FHJ82_13795 ENOG4108Z0Z intracellular protease Pfpi family FHJ82_13815 ENOG4108NGU Transcriptional regulator FHJ82_13830 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FHJ82_13845 ENOG4105F1V Acetoin utilization protein FHJ82_13850 ENOG4105W87 Cbs domain FHJ82_13855 ENOG4105DGU Histone deacetylase FHJ82_13860 ENOG4105ER2 Ompa motb domain protein FHJ82_13865 ENOG4107R0U MotA TolQ exbB proton channel FHJ82_13870 ENOG4105ETE Transcriptional regulator (LacI family FHJ82_13875 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FHJ82_13895 ENOG4105DFU Cell wall formation (By similarity) FHJ82_13905 ENOG4108VDD TRNA binding domain protein FHJ82_13920 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FHJ82_13935 ENOG4105C6K Malic enzyme FHJ82_13940 ENOG4105C8F Beta-lactamase domain protein FHJ82_13945 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FHJ82_13955 ENOG4108V15 phosphotransferase enzyme family FHJ82_13970 ENOG4107F58 2'-5' rna ligase FHJ82_13975 ENOG4105C6T cysteine synthase FHJ82_13980 ENOG4107QSE Dipeptidase FHJ82_13985 ENOG4105C7N Xanthine uracil vitamin C permease FHJ82_14005 ENOG4105YW5 deoR family transcriptional regulator FHJ82_14020 ENOG4105CBX hi0933 family FHJ82_14030 ENOG4105C94 Transporter FHJ82_14070 ENOG41085GJ domain protein FHJ82_14075 ENOG4105C8T Leucyl-tRNA synthetase FHJ82_14085 ENOG4105BZU Histidine kinase FHJ82_14090 ENOG410605W Major Facilitator FHJ82_14105 ENOG4105C19 ABC transporter FHJ82_14110 ENOG4105EWM Histidine kinase FHJ82_14120 ENOG4107R34 abc transporter permease protein FHJ82_14125 ENOG4105C19 ABC transporter FHJ82_14145 ENOG4105DVE abc transporter atp-binding protein FHJ82_14150 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FHJ82_14160 ENOG4105N5T Radical SAM Protein FHJ82_14175 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FHJ82_14185 ENOG4105E8V Alpha Beta Hydrolase Fold protein FHJ82_14190 ENOG4108Z0R Transferase FHJ82_14195 ENOG4105C85 amino acid FHJ82_14200 ENOG4105CAQ asparagine synthetase FHJ82_14205 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FHJ82_14210 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FHJ82_14225 ENOG4105D2X ABC transporter substrate-binding protein FHJ82_14235 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FHJ82_14250 ENOG4108RMU ferritin dps family protein FHJ82_14265 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FHJ82_14270 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FHJ82_14275 ENOG4108V2W Carbonate dehydratase FHJ82_14280 ENOG4105NRA 50s ribosomal protein l31 type b FHJ82_14300 ENOG4105DTQ mandelate racemase muconate lactonizing FHJ82_14305 ENOG4105CEY Amp-dependent synthetase and ligase FHJ82_14310 ENOG4108IPT Naphthoate synthase FHJ82_14315 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FHJ82_14320 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FHJ82_14325 ENOG4105E4F Isochorismate synthase FHJ82_14460 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FHJ82_14465 ENOG4105DZ6 Band 7 protein FHJ82_14475 ENOG4106DF1 FHJ82_14480 ENOG4108VNY MOSC domain protein FHJ82_14485 ENOG4108JB8 alcohol dehydrogenase FHJ82_14495 ENOG4105TRT Transcriptional regulator FHJ82_14510 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FHJ82_14515 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FHJ82_14535 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FHJ82_14545 ENOG4105EE0 oxidoreductase FHJ82_14550 ENOG4108Z0Z intracellular protease Pfpi family FHJ82_14555 ENOG4105C8Q Methyl-accepting chemotaxis FHJ82_14560 ENOG4105C8Q Methyl-accepting chemotaxis FHJ82_14565 ENOG4105C8Q Methyl-accepting chemotaxis FHJ82_14570 ENOG4105C8Q Methyl-accepting chemotaxis FHJ82_14585 ENOG4105EA8 2-Nitropropane dioxygenase FHJ82_14590 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FHJ82_14600 ENOG4105C37 (CBS) domain FHJ82_14615 ENOG4107PBV potassium channel FHJ82_14620 ENOG4107PBV potassium channel FHJ82_14635 ENOG4107QYV phosphohexose isomerase FHJ82_14650 ENOG4105CHJ isochorismatase hydrolase FHJ82_14665 ENOG4107QW4 alcohol dehydrogenase FHJ82_14670 ENOG4105WG9 Conserved Protein FHJ82_14680 ENOG4105CHM Aminotransferase FHJ82_14685 ENOG4108ZB6 transcriptional regulator AsnC family FHJ82_14690 ENOG4108MUZ hydrolase FHJ82_14700 ENOG4105C87 Aminotransferase class I and II FHJ82_14705 ENOG4108HGU Histidine kinase FHJ82_14710 ENOG4105Y38 Kinase-associated protein B FHJ82_14725 ENOG4105BZ4 penicillin-binding protein FHJ82_14730 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FHJ82_14745 ENOG4108MRH transcriptional regulatory protein FHJ82_14750 ENOG4105DIH basic membrane FHJ82_14755 ENOG4108JQ9 ABC transporter FHJ82_14760 ENOG4105UIB (ABC) transporter FHJ82_14775 ENOG4105D65 subunit l FHJ82_14780 ENOG4105HC0 Na H antiporter FHJ82_14785 ENOG4108ZE9 Monovalent cation H antiporter subunit C FHJ82_14790 ENOG4108JPZ Monovalent cation H antiporter subunit D FHJ82_14795 ENOG4105SC1 monovalent cation H antiporter subunit E FHJ82_14805 ENOG4105KJM monovalent cation h antiporter subunit g FHJ82_14810 ENOG4105KA0 thioesterase Superfamily protein FHJ82_14820 ENOG4105BZU Histidine kinase FHJ82_14850 ENOG4105D58 Diguanylate phosphodiesterase FHJ82_14855 ENOG4105DAP Nicotinate phosphoribosyltransferase FHJ82_14880 ENOG4105C02 permease FHJ82_14895 ENOG410904N short-chain dehydrogenase reductase FHJ82_14930 ENOG4108K8K Transcriptional regulator FHJ82_14935 ENOG4105DCF alanine dehydrogenase FHJ82_14945 ENOG4105WQT MbtH domain protein FHJ82_14950 ENOG4105CEY Amp-dependent synthetase and ligase FHJ82_14955 ENOG4105WQI isochorismatase FHJ82_14960 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FHJ82_14965 ENOG4105E4F Isochorismate synthase FHJ82_14970 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FHJ82_14975 ENOG4105NIV Esterase FHJ82_14995 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FHJ82_15005 ENOG41069ER domain protein FHJ82_15020 ENOG4105CEP NADH dehydrogenase FHJ82_15035 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FHJ82_15050 ENOG4105CJ1 ABC, transporter FHJ82_15070 ENOG4105D9U N-acetyltransferase FHJ82_15075 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FHJ82_15080 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FHJ82_15085 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FHJ82_15095 ENOG4105ZKE UPF0349 protein FHJ82_15110 ENOG41083MR nifu domain-containing protein FHJ82_15115 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FHJ82_15120 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FHJ82_15125 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FHJ82_15130 ENOG4105D6E homoserine dehydrogenase FHJ82_15140 ENOG4108W5N phosphatidylglycerophosphatase a FHJ82_15145 ENOG4105D4U had-superfamily hydrolase, subfamily iia FHJ82_15155 ENOG4105MMD transcriptional regulator FHJ82_15165 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FHJ82_15170 ENOG4105FAA peptidase M23 FHJ82_15175 ENOG4108YTE sporulation protein YunB FHJ82_15180 ENOG4107R8B 5'-nucleotidase FHJ82_15200 ENOG4105CD3 dihydroorotase FHJ82_15205 ENOG4105G9B Transcriptional regulator FHJ82_15235 ENOG4105C5R Aminotransferase FHJ82_15245 ENOG4108K8S endonuclease I FHJ82_15250 ENOG4108IJ9 (ABC) transporter FHJ82_15255 ENOG4105FDP GntR family transcriptional regulator FHJ82_15260 ENOG4108KPW sugar kinase FHJ82_15265 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FHJ82_15270 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FHJ82_15275 ENOG4105XN3 extracellular solute-binding protein family 1 FHJ82_15280 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FHJ82_15285 ENOG4108Z6Z Transcriptional regulator FHJ82_15310 ENOG4105PKS Excinuclease abc c subunit domain protein FHJ82_15315 ENOG4107VFR oxidoreductase FHJ82_15335 ENOG41083Q9 chitosanase FHJ82_15340 ENOG4105DIW FeS assembly protein SUFB FHJ82_15345 ENOG4108UNV SUF system FeS assembly protein, NifU family FHJ82_15350 ENOG4105C9B Cysteine desulfurase FHJ82_15355 ENOG4105JRK feS assembly protein SufD FHJ82_15360 ENOG4105C3K feS assembly ATPase SufC FHJ82_15375 ENOG4105D01 (LipO)protein FHJ82_15380 ENOG4108UMI ABC transporter, permease FHJ82_15385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FHJ82_15410 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FHJ82_15415 ENOG41080E8 Transcriptional regulator, Spx MgsR family FHJ82_15420 ENOG4105C1G acyl-Coa dehydrogenase FHJ82_15425 ENOG4105CHU acetyl-coa acetyltransferase FHJ82_15455 ENOG41067TZ transcriptional regulator, MarR family FHJ82_15460 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHJ82_15465 ENOG4105MDS 4-oxalocrotonate tautomerase FHJ82_15475 ENOG4105EGI Transcriptional regulator FHJ82_15485 ENOG4105C5Q Transcriptional regulator FHJ82_15505 ENOG4105E0A ABC, transporter FHJ82_15520 ENOG4105E1F short-chain dehydrogenase reductase FHJ82_15525 ENOG4105HUF DNA protection during starvation protein FHJ82_15530 ENOG4105C0H protease FHJ82_15545 ENOG4105F3H Histidine kinase FHJ82_15555 ENOG41067SE Tetr family transcriptional regulator FHJ82_15560 ENOG4105C9Q fumarate hydratase class II FHJ82_15585 ENOG4105WH1 Two component transcriptional regulator luxr family FHJ82_15590 ENOG4105ENE Histidine kinase FHJ82_15605 ENOG41087YS Phage shock protein A FHJ82_15620 ENOG4108WBT adenosyltransferase FHJ82_15625 ENOG4105E0A ABC, transporter FHJ82_15640 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FHJ82_15645 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FHJ82_15655 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHJ82_15665 ENOG4106DF4 Sigma-70, region 4 FHJ82_15675 ENOG4105F0F Oxalate decarboxylase FHJ82_15685 ENOG4105E0A ABC, transporter FHJ82_15690 ENOG4105EHG Permease protein FHJ82_15695 ENOG4105DQ5 transport system permease protein FHJ82_15705 ENOG4105D5Q Arginine ornithine antiporter FHJ82_15720 ENOG4107K5X Membrane-bound metal-dependent hydrolase FHJ82_15725 ENOG4107QZ2 Sulfatase FHJ82_15730 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FHJ82_15735 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FHJ82_15740 ENOG4105E0C molybdate abc transporter FHJ82_15745 ENOG4105WH1 Two component transcriptional regulator luxr family FHJ82_15750 ENOG4105BZU Histidine kinase FHJ82_15755 ENOG4105CJ1 ABC, transporter FHJ82_15765 ENOG4108KYE ABC-2 type transporter FHJ82_15780 ENOG4105EEQ Na H antiporter FHJ82_15790 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FHJ82_15795 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FHJ82_15800 ENOG4105EEM helicase FHJ82_15805 ENOG4105EN6 Membrane FHJ82_15820 ENOG4107ZQN disulfide bond FHJ82_15825 ENOG4105C59 p-type ATPase FHJ82_15830 ENOG4105C59 p-type ATPase FHJ82_15835 ENOG410681U heavy metal transport detoxification protein FHJ82_15840 ENOG4105VPX protein, conserved in bacteria FHJ82_15845 ENOG4105D9R oxidoreductase FHJ82_15850 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FHJ82_15865 ENOG4105DEN Luciferase family FHJ82_15870 ENOG4105CDA abc transporter atp-binding protein FHJ82_15895 ENOG4108XSB acetyltransferase, (GNAT) family FHJ82_15900 ENOG4108KSA LysR family transcriptional regulator FHJ82_15905 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FHJ82_15950 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FHJ82_15955 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FHJ82_15965 ENOG4105XZU Preprotein translocase, subunit SecG FHJ82_15985 ENOG4105KVH Transcriptional regulator FHJ82_16010 ENOG4105DA5 (ABC) transporter FHJ82_16015 ENOG4105R40 Glycine betaine carnitine choline FHJ82_16020 ENOG4108HQR Glycine betaine FHJ82_16025 ENOG4105E90 ABC transporter FHJ82_16030 ENOG4108IJ8 ABC transporter FHJ82_16035 ENOG4107HG4 Transcriptional regulator FHJ82_16040 ENOG4105R40 Glycine betaine carnitine choline FHJ82_16045 ENOG4108HQR Glycine betaine FHJ82_16050 ENOG4105E90 ABC transporter FHJ82_16055 ENOG4108IJ8 ABC transporter FHJ82_16060 ENOG4107HG4 Transcriptional regulator FHJ82_16065 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FHJ82_16075 ENOG4105T65 Membrane-associated protein FHJ82_16080 ENOG4108W0I acetyltransferase FHJ82_16095 ENOG4105FJR Lmbe family FHJ82_16115 ENOG4108IAJ Nad-dependent epimerase dehydratase FHJ82_16120 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FHJ82_16125 ENOG4107QQG Dehydrogenase FHJ82_16130 ENOG4105IIU Aminopeptidase FHJ82_16135 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FHJ82_16140 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FHJ82_16145 ENOG4105CP7 Triose-phosphate isomerase FHJ82_16150 ENOG4105BZA Phosphoglycerate kinase FHJ82_16160 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FHJ82_16175 ENOG4105CMD Transcriptional regulator, GntR family FHJ82_16180 ENOG4105DEN Luciferase family FHJ82_16190 ENOG4105GZI Transcriptional regulator FHJ82_16195 ENOG4107RT3 EamA-like transporter family FHJ82_16215 ENOG410667J hydrolase FHJ82_16220 ENOG4106KNT transcriptional regulator FHJ82_16225 ENOG4105CMG Carbohydrate kinase FHJ82_16230 ENOG4105C6Z Gluconate FHJ82_16255 ENOG4107QR9 Iron-sulfur cluster binding protein FHJ82_16260 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FHJ82_16265 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FHJ82_16270 ENOG4105JXH GntR family transcriptional regulator FHJ82_16275 ENOG4105DAA L-lactate FHJ82_16280 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHJ82_16290 ENOG4108ZPC Polysaccharide pyruvyl transferase FHJ82_16295 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FHJ82_16300 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family FHJ82_16305 ENOG4105D3Q Sugar transferase FHJ82_16315 ENOG4105K64 Glycosyl transferase, family 2 FHJ82_16325 ENOG4107QRS glycosyltransferase group 2 family protein FHJ82_16330 ENOG41068W6 Capsular polysaccharide biosynthesis protein FHJ82_16335 ENOG4108KMV Glycosyl transferase (Group 1 FHJ82_16340 ENOG4105K64 Glycosyl transferase, family 2 FHJ82_16345 ENOG4108PQP glycosyl transferase group 1 FHJ82_16355 ENOG4108QV3 biosynthesis protein FHJ82_16360 ENOG4105HTX biosynthesis protein FHJ82_16370 ENOG4105EBR Carboxylesterase FHJ82_16375 ENOG4105NAE bifunctional deaminase-reductase domain protein FHJ82_16385 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FHJ82_16390 ENOG4105PY6 Phenolic acid decarboxylase FHJ82_16435 ENOG4108HKT sucrose-6-phosphate hydrolase FHJ82_16440 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FHJ82_16445 ENOG4105ETE Transcriptional regulator (LacI family FHJ82_16450 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FHJ82_16455 ENOG4107URF beta-phospho-glucomutase FHJ82_16460 ENOG4105CG3 alpha amylase, catalytic region FHJ82_16475 ENOG4105EG2 ABC transporter, permease FHJ82_16480 ENOG4105D56 permease protein FHJ82_16485 ENOG4107FKK extracellular solute-binding protein family 1 FHJ82_16490 ENOG4108IUK alpha amylase, catalytic FHJ82_16495 ENOG4105FKQ transcriptional regulator FHJ82_16500 ENOG4108URH decarboxylase FHJ82_16505 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FHJ82_16510 ENOG4105CHH sulfate transporter FHJ82_16515 ENOG4108V2W Carbonate dehydratase FHJ82_16525 ENOG4105C5I Dehydrogenase FHJ82_16530 ENOG4105GGE ribonuclease FHJ82_16535 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FHJ82_16540 ENOG4105KRI phosphocarrier protein (HPr FHJ82_16545 ENOG4105CIE May be required for sporulation (By similarity) FHJ82_16550 ENOG4105CHW UPF0052 protein FHJ82_16555 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FHJ82_16560 ENOG4108Z4K mutator MutT protein FHJ82_16565 ENOG4105C3M thioredoxin reductase FHJ82_16580 ENOG4105BZU Histidine kinase FHJ82_16585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHJ82_16590 ENOG4105BZ1 (ABC) transporter FHJ82_16595 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FHJ82_16600 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FHJ82_16605 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FHJ82_16610 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FHJ82_16615 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FHJ82_16620 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FHJ82_16625 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FHJ82_16630 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FHJ82_16640 ENOG4108S4C acetyltransferase FHJ82_16645 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FHJ82_16655 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FHJ82_16660 ENOG4105CE4 GlcNAc 6-P deacetylase FHJ82_16665 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FHJ82_16675 ENOG4105J7D transcriptional regulator FHJ82_16680 ENOG41088CQ domain protein FHJ82_16685 ENOG41086DT Membrane protein of unknown function FHJ82_16690 ENOG41067S9 phage shock protein C, PspC FHJ82_16695 ENOG4108PY7 FHJ82_16710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FHJ82_16715 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FHJ82_16730 ENOG4105MKU Transcriptional regulator FHJ82_16760 ENOG4105CN1 protease FHJ82_16765 ENOG4108M26 parallel beta-helix repeat protein FHJ82_16770 ENOG4105CRP Part of the ABC transporter FtsEX involved in FHJ82_16775 ENOG4105CAK Cell division ATP-binding protein ftsE FHJ82_16795 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FHJ82_16800 ENOG4105MS2 ribosomal subunit Interface protein FHJ82_16815 ENOG4105MQ3 flagellar protein FliS FHJ82_16825 ENOG4105I03 Flagellin FHJ82_16830 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FHJ82_16835 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FHJ82_16845 ENOG4105DTJ flagellar hook-associated protein FHJ82_16850 ENOG4105E1Q flagellar hook-associated protein FHJ82_16865 ENOG4105RU3 FHJ82_16870 ENOG41081UC Inherit from COG: Competence protein FHJ82_16890 ENOG4105WH1 Two component transcriptional regulator luxr family FHJ82_16895 ENOG4105BZU Histidine kinase FHJ82_16900 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FHJ82_16905 ENOG4108KGH TRANSCRIPTIONal FHJ82_16910 ENOG4105ESV Glycosyl transferase, family 4 FHJ82_16915 ENOG4107EF8 Glycosyl transferase (Group 1 FHJ82_16930 ENOG4105QZI O-Antigen Polymerase FHJ82_16935 ENOG4105C6Y Udp-glucose 6-dehydrogenase FHJ82_16940 ENOG4107RA4 Glycosyl transferase (Group 1 FHJ82_16945 ENOG4105PSV Polysaccharide Biosynthesis Protein FHJ82_16950 ENOG4105D3Q Sugar transferase FHJ82_16955 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FHJ82_16960 ENOG4105JFG SpoIID LytB domain protein FHJ82_16975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FHJ82_16980 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FHJ82_16985 ENOG4105EY8 ABC transporter FHJ82_16995 ENOG4107SJB teichoic acid biosynthesis FHJ82_17005 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FHJ82_17015 ENOG4107RZX Teichoic acid biosynthesis protein FHJ82_17025 ENOG4105DG6 mannose-6-phosphate isomerase FHJ82_17040 ENOG4108NHD germination protein FHJ82_17045 ENOG4107R8N Glycosyl transferase, family 2 FHJ82_17050 ENOG4105C54 Major Facilitator superfamily FHJ82_17055 ENOG4108KGH TRANSCRIPTIONal FHJ82_17060 ENOG4105J7I hydrolase FHJ82_17065 ENOG4106UBQ FHJ82_17070 ENOG4105K4H Nlp p60 protein FHJ82_17080 ENOG4105PNM synthesis protein FHJ82_17090 ENOG4105N98 Capsule biosynthesis protein capB FHJ82_17100 ENOG4105E1K spore germination protein FHJ82_17115 ENOG4105ETE Transcriptional regulator (LacI family FHJ82_17120 ENOG4108RVA ribokinase FHJ82_17125 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FHJ82_17130 ENOG4105C2J ABC transporter FHJ82_17135 ENOG4105CNN ABC, transporter FHJ82_17140 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FHJ82_17150 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FHJ82_17155 ENOG4107FQX Alpha-acetolactate decarboxylase FHJ82_17165 ENOG4107RSM transcriptional regulator FHJ82_17180 ENOG4106UIA FHJ82_17195 ENOG4107XC4 flavin reductase domain protein, FMN-binding FHJ82_17205 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FHJ82_17215 ENOG4105CAH Chromate FHJ82_17220 ENOG4105FGV Chromate FHJ82_17230 ENOG4108WS4 fmn reductase FHJ82_17235 ENOG4107V2S Transcriptional regulator FHJ82_17240 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FHJ82_17285 ENOG4108XI2 Domain of unknown function (DUF1963) FHJ82_17290 ENOG4105C6Y Udp-glucose 6-dehydrogenase FHJ82_17295 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FHJ82_17300 ENOG4107YJ4 chain length determinant protein FHJ82_17305 ENOG4105HTX biosynthesis protein FHJ82_17320 ENOG4105KBK Zinc finger, swim domain protein FHJ82_17325 ENOG4105C0D helicase FHJ82_17330 ENOG410667J hydrolase FHJ82_17335 ENOG4105E98 transcriptional regulator DeoR family FHJ82_17340 ENOG4105Z8H single-stranded DNA-binding protein FHJ82_17355 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FHJ82_17360 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FHJ82_17370 ENOG4105CGA flagellar basal-body rod protein FlgG FHJ82_17380 ENOG4105DFF Rod shape-determining protein mreb FHJ82_17385 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FHJ82_17390 ENOG4107MII Sugar-specific transcriptional regulator TrmB FHJ82_17395 ENOG4105CZM Major Facilitator FHJ82_17400 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FHJ82_17405 ENOG41080V3 Major Facilitator superfamily FHJ82_17410 ENOG4105D3W isochorismatase FHJ82_17415 ENOG4105BZU Histidine kinase FHJ82_17425 ENOG4105CNI cell division protein FtsW FHJ82_17430 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FHJ82_17440 ENOG4105FRN stage II sporulation protein FHJ82_17445 ENOG4107TCE N-acetyltransferase FHJ82_17460 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FHJ82_17465 ENOG4106BRK FHJ82_17470 ENOG4107T94 Endo-14-beta-xylanase FHJ82_17480 ENOG4108Z40 Transcriptional regulator FHJ82_17485 ENOG4105CQM Urea amidohydrolase subunit alpha FHJ82_17490 ENOG4105KI2 Urea amidohydrolase subunit beta FHJ82_17495 ENOG4108YZ9 Urea amidohydrolase subunit gamma FHJ82_17515 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FHJ82_17520 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FHJ82_17525 ENOG4108TF4 von Willebrand factor, type A FHJ82_17545 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FHJ82_17555 ENOG4106778 Protein of unknown function (DUF1146) FHJ82_17565 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FHJ82_17570 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FHJ82_17575 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FHJ82_17580 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FHJ82_17585 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FHJ82_17600 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FHJ82_17610 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FHJ82_17615 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FHJ82_17620 ENOG4108UIC UPF0340 protein FHJ82_17625 ENOG4108YZG isomerase FHJ82_17630 ENOG4107WAU Protein tyrosine phosphatase FHJ82_17635 ENOG410815N Probably functions as a manganese efflux pump (By similarity) FHJ82_17640 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FHJ82_17670 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FHJ82_17675 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FHJ82_17685 ENOG4107TT2 Auxin Efflux Carrier FHJ82_17690 ENOG4105C6K Malic enzyme FHJ82_17695 ENOG4107104 thymidine kinase FHJ82_17705 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FHJ82_17710 ENOG4105CBT Fructose-1,6-bisphosphatase FHJ82_17715 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FHJ82_17725 ENOG4105D2N Aldolase FHJ82_17730 ENOG410812K response regulator receiver protein FHJ82_17740 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FHJ82_17750 ENOG4105DF6 Fe-S oxidoreductase FHJ82_17760 ENOG4105E5J UV damage endonuclease FHJ82_17770 ENOG4105BZ1 (ABC) transporter FHJ82_17775 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FHJ82_17790 ENOG4105R3A Nitrate reductase FHJ82_17795 ENOG4108IUE nitrate reductase beta subunit FHJ82_17815 ENOG4107V6Q Cyclic nucleotide-binding domain FHJ82_17825 ENOG4105C75 arginyL-tRNA synthetase FHJ82_17830 ENOG410684U Domain of unknown function (DUF1934) FHJ82_17855 ENOG4107JM4 Tetratricopeptide repeat FHJ82_17865 ENOG4105CYW agmatinase FHJ82_17875 ENOG4105BZ4 penicillin-binding protein FHJ82_17885 ENOG4108XFG YwhD family FHJ82_17890 ENOG4108Z4T Peptidase M50 FHJ82_17895 ENOG41069HH 4-oxalocrotonate tautomerase FHJ82_17900 ENOG41067TZ transcriptional regulator, MarR family FHJ82_17910 ENOG4105CUB amino acid FHJ82_17920 ENOG4105DCI Phosphohydrolase FHJ82_17930 ENOG4108VCI transcription factor, rsfa family FHJ82_17935 ENOG4105K7K Transcriptional regulator FHJ82_17945 ENOG4105CJ1 ABC, transporter FHJ82_17950 ENOG4108TU7 Inherit from COG: (ABC) transporter FHJ82_17975 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FHJ82_17980 ENOG4105DUM transcriptional regulator, lysR family FHJ82_17985 ENOG4105HMI Membrane FHJ82_17990 ENOG4108IJ2 phosphate acetyltransferase FHJ82_17995 ENOG4107JTW chlorite dismutase FHJ82_18005 ENOG4105CHM Aminotransferase FHJ82_18035 ENOG4105FCW Major Facilitator superfamily FHJ82_18040 ENOG4105C2C drug resistance transporter, Bcr CflA FHJ82_18055 ENOG4105C26 Dehydrogenase FHJ82_18060 ENOG4105D82 Glutamate dehydrogenase FHJ82_18070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHJ82_18090 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase FHJ82_18095 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FHJ82_18100 ENOG4105C1B dTDP-glucose 4-6-dehydratase FHJ82_18105 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FHJ82_18110 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG FHJ82_18115 ENOG4107TY6 Acylneuraminate cytidylyltransferase FHJ82_18125 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD FHJ82_18130 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FHJ82_18165 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FHJ82_18170 ENOG4108RJ9 Glycosyl transferase, family 2 FHJ82_18190 ENOG4105DWF phosphomethylpyrimidine kinase FHJ82_18205 ENOG4105C5Y PTS System FHJ82_18220 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FHJ82_18225 ENOG4105DEN Luciferase family FHJ82_18230 ENOG4108DBC nitroreductase FHJ82_18240 ENOG4105I4A GCN5-related N-acetyltransferase FHJ82_18260 ENOG4105BZ9 Cytochrome C oxidase, subunit I FHJ82_18265 ENOG4105E2S oxidase) subunit II FHJ82_18270 ENOG4107BMA Transglycosylase associated protein FHJ82_18280 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FHJ82_18285 ENOG4105WH5 Teichoic acid glycosylation protein FHJ82_18310 ENOG4107ZXU DSBA oxidoreductase FHJ82_18315 ENOG4105DBE peroxidase FHJ82_18320 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FHJ82_18325 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FHJ82_18330 ENOG4105CMU LysR family (Transcriptional regulator FHJ82_18335 ENOG4105VAW lrga family FHJ82_18340 ENOG41067MG lrgb family FHJ82_18350 ENOG4107TXC Transcriptional regulator FHJ82_18360 ENOG4105DR4 Methyltransferase FHJ82_18370 ENOG4105CK1 PTS System FHJ82_18375 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FHJ82_18380 ENOG4105X1N Glycosyl transferase family 8 FHJ82_18390 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FHJ82_18405 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FHJ82_18410 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FHJ82_18415 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FHJ82_18420 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FHJ82_18425 ENOG4105CM2 brancheD-chain amino acid aminotransferase FHJ82_18430 ENOG4105F8D glycoside hydrolase family 4 FHJ82_18435 ENOG4105VCP PTS System FHJ82_18440 ENOG4105CK1 PTS System FHJ82_18445 ENOG4105VZJ PTS System FHJ82_18450 ENOG4105EMD TRANSCRIPTIONal FHJ82_18465 ENOG4105DQ5 transport system permease protein FHJ82_18470 ENOG4105EHG Permease protein FHJ82_18480 ENOG41082YX Transcriptional regulator, arsr family FHJ82_18485 ENOG4107R5R arsenical pump membrane protein FHJ82_18490 ENOG4105VZJ PTS System FHJ82_18495 ENOG4105VCP PTS System FHJ82_18500 ENOG4105CK1 PTS System FHJ82_18505 ENOG4105CS2 ec 3.2.1.21 FHJ82_18515 ENOG4105DG6 mannose-6-phosphate isomerase FHJ82_18525 ENOG4105CH6 catalase FHJ82_18530 ENOG4107QHE Choloylglycine hydrolase FHJ82_18535 ENOG4105ETS cytosine purines uracil thiamine allantoin FHJ82_18560 ENOG4108NEV two component transcriptional regulator, LytTR family FHJ82_18580 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FHJ82_18585 ENOG4108JJ8 (ABC) transporter FHJ82_18590 ENOG4108JJ9 ABC, transporter FHJ82_18595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FHJ82_18600 ENOG4105C4M (Ubiquinol oxidase) subunit I FHJ82_18605 ENOG4105D2K citrate carrier protein FHJ82_18610 ENOG4107BJW polysaccharide deacetylase FHJ82_18625 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FHJ82_18635 ENOG4105CMR udp-glucose 4-epimerase FHJ82_18640 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FHJ82_18655 ENOG4105DHI Methyltransferase FHJ82_18675 ENOG4105CH6 catalase FHJ82_18680 ENOG4105D4T Citrate transporter FHJ82_18695 ENOG4105DEU major facilitator superfamily FHJ82_18700 ENOG4105C1J atp-dependent rna helicase FHJ82_18705 ENOG4108NR7 pectate lyase FHJ82_18715 ENOG4107YZX Universal stress protein FHJ82_18780 ENOG4105C84 Histidine ammonia-lyase FHJ82_18785 ENOG4105CGP Urocanate hydratase FHJ82_18790 ENOG4105CI2 imidazolone-5-propionate hydrolase FHJ82_18795 ENOG4107W25 arginase agmatinase formiminoglutamase FHJ82_18805 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FHJ82_18810 ENOG4105D9N nucleoside FHJ82_18815 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FHJ82_18820 ENOG4107RHR regulatoR FHJ82_18825 ENOG410667J hydrolase FHJ82_18855 ENOG4108V5C ABC transporter FHJ82_18890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHJ82_18915 ENOG4105WZ4 isomerase FHJ82_18920 ENOG4105F0H myo-inositol catabolism protein FHJ82_18925 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FHJ82_18935 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FHJ82_18945 ENOG4105EDK PfkB domain protein FHJ82_18955 ENOG4105C26 Dehydrogenase FHJ82_18965 ENOG4105CPC Aldo Keto reductase FHJ82_18970 ENOG4107QNK )-transporter FHJ82_18975 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FHJ82_18985 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FHJ82_18990 ENOG4108S01 response regulator FHJ82_18995 ENOG4108ZGX Histidine kinase FHJ82_19000 ENOG4105ECK Fatty Acid Desaturase FHJ82_19005 ENOG4105ST3 Transcriptional regulator FHJ82_19010 ENOG4105C26 Dehydrogenase FHJ82_19015 ENOG4108ITS PQQ enzyme repeat FHJ82_19025 ENOG4105WAB arsR family transcriptional regulator FHJ82_19030 ENOG4105F27 Major Facilitator FHJ82_19035 ENOG41085PJ rdd domain containing protein FHJ82_19045 ENOG4105D3R alkyl hydroperoxide reductase FHJ82_19050 ENOG4108JU3 Alkyl hydroperoxide reductase FHJ82_19055 ENOG4107R3N Filamentation induced by cAMP protein fic FHJ82_19060 ENOG4105C85 amino acid FHJ82_19065 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FHJ82_19070 ENOG4108XHQ (2Fe-2S)-binding domain protein FHJ82_19090 ENOG4105XRQ Xanthine dehydrogenase accessory factor FHJ82_19125 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FHJ82_19145 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FHJ82_19150 ENOG4105CPC Aldo Keto reductase FHJ82_19155 ENOG4105WQG acetyltransferase FHJ82_19165 ENOG41066UZ arginase EC 3.5.3.1 FHJ82_19170 ENOG4108IQI permease FHJ82_19175 ENOG4105C8Y Acetylornithine aminotransferase FHJ82_19185 ENOG41082BM Transcriptional regulator, arsr family FHJ82_19190 ENOG4108JUB Transcriptional regulator FHJ82_19200 ENOG4105C5H ABC transporter FHJ82_19215 ENOG4105D06 uba thif-type nad fad binding protein FHJ82_19220 ENOG41062D9 Histidine kinase FHJ82_19225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHJ82_19230 ENOG4105C0H protease FHJ82_19235 ENOG4105Q2H domain protein FHJ82_19250 ENOG4105BZU Histidine kinase FHJ82_19255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHJ82_19285 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FHJ82_19290 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FHJ82_19295 ENOG4105CDU Replicative dna helicase FHJ82_19315 ENOG4105EDW glycosyl transferase, family 39 FHJ82_19320 ENOG4107QPH glycogen) synthase FHJ82_19330 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FHJ82_19340 ENOG4105CPK Glycosyl transferase (Group 1 FHJ82_19360 ENOG4105BZR domain protein FHJ82_19365 ENOG4108XMW Membrane FHJ82_19380 ENOG4105KVH Transcriptional regulator FHJ82_19385 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FHJ82_19390 ENOG4108UZ3 Transporter FHJ82_19395 ENOG4105EDQ levansucrase EC 2.4.1.10 FHJ82_19400 ENOG4108HKT sucrose-6-phosphate hydrolase FHJ82_19425 ENOG4108TVJ Nitroreductase FHJ82_19430 ENOG4105FS7 Transcriptional regulator FHJ82_19440 ENOG4108U05 Transcriptional regulator FHJ82_19445 ENOG41082BV acetyltransferase FHJ82_19455 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FHJ82_19460 ENOG4105CMU LysR family (Transcriptional regulator FHJ82_19465 ENOG4105DTD Dehydrogenase FHJ82_19475 ENOG4107Y9U Membrane FHJ82_19480 ENOG4105C7Z Conserved Protein FHJ82_19505 ENOG4105C7Z Conserved Protein FHJ82_19510 ENOG4107FCW Abortive infection protein FHJ82_19520 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FHJ82_19530 ENOG4105CGK Exodeoxyribonuclease III FHJ82_19535 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FHJ82_19545 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FHJ82_19550 ENOG4108UUM single-stranded DNA-binding protein FHJ82_19555 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FHJ82_19560 ENOG4105C3G gtp-binding protein FHJ82_19565 ENOG4108J2R molybdopterin oxidoreductase FHJ82_19570 ENOG4105VDK protein, conserved in bacteria FHJ82_19585 ENOG4108ZDA Sporulation protein YyaC FHJ82_19590 ENOG4105FA0 parb-like partition protein FHJ82_19595 ENOG4107QJE Chromosome Partitioning Protein FHJ82_19610 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FHJ82_19615 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FHJ82_19630 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)