locus-tag class description DN407_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN407_00015 ENOG410848D S4 domain protein YaaA DN407_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN407_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DN407_00100 ENOG4105ZMH deoxynucleoside kinase DN407_00110 ENOG4105GTG Isochorismatase DN407_00120 ENOG4108Z6B deaminase DN407_00130 ENOG4105C6E dna polymerase iii DN407_00150 ENOG41067KS pro-sigma K processing DN407_00185 ENOG4105CXN decarboxylase DN407_00195 ENOG4105FA2 dna polymerase iii DN407_00200 ENOG4105MA4 psp1 domain protein DN407_00210 ENOG41060K3 Methyltransferase DN407_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DN407_00225 ENOG4105KRN Transcriptional regulator, abrb family DN407_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN407_00235 ENOG4105F8V Hydrolase, tatD family DN407_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DN407_00250 ENOG4105XFA sporulation peptidase YabG DN407_00255 ENOG4105W42 Veg protein DN407_00270 ENOG4105DFT pur operon repressor DN407_00275 ENOG4105KME endoribonuclease L-psp DN407_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DN407_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DN407_00305 ENOG4108JA2 transcriptioN-repair coupling factor DN407_00310 ENOG4108M14 stage v sporulation protein t DN407_00320 ENOG4108IY2 MazG family DN407_00325 ENOG41082I2 s4 domain protein DN407_00330 ENOG4105VYY sporulation protein yabp DN407_00345 ENOG41060GV RNA binding s1 domain protein DN407_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DN407_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN407_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DN407_00390 ENOG4105C6T cysteine synthase DN407_00395 ENOG4105CRQ synthase (Component I) DN407_00400 ENOG4105DDQ anthranilate synthase DN407_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DN407_00410 ENOG4105EEI dihydropteroate synthase DN407_00415 ENOG4105KRF dihydroneopterin aldolase DN407_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DN407_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DN407_00520 ENOG4108Z0C Uvrb UvrC protein DN407_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DN407_00545 ENOG4105CTP PilT protein domain protein DN407_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DN407_00565 ENOG4105D7W serine acetyltransferase DN407_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 DN407_00585 ENOG4105M0M Tetracycline resistance protein DN407_00590 ENOG4105QIV RNA polymerase DN407_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DN407_00630 ENOG4107Y49 methyltransferase DN407_00645 ENOG4105XPM ribosomal protein DN407_00755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DN407_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN407_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN407_00800 ENOG41067V7 50S ribosomal protein L36 DN407_00825 ENOG4108JJB ABC transporter DN407_00830 ENOG4108JJB ABC transporter DN407_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DN407_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN407_00865 ENOG4105D1F ATP-binding protein DN407_00880 ENOG4108NMV polysaccharide deacetylase DN407_00960 ENOG4105C8B TIGR00159 family DN407_00965 ENOG4107U5W ybbr family DN407_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DN407_01000 ENOG4108PSK reductase DN407_01005 ENOG4108UMI ABC transporter, permease DN407_01010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DN407_01015 ENOG4105D01 (LipO)protein DN407_01020 ENOG4105CB2 alcohol dehydrogenase DN407_01030 ENOG4105IQ5 FAD linked oxidase domain protein DN407_01045 ENOG4105C2C drug resistance transporter, Bcr CflA DN407_01060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN407_01065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN407_01070 ENOG4105C3U ABC transporter DN407_01075 ENOG4108JQ7 (ABC) transporter DN407_01105 ENOG4108J59 Extracellular solute-binding protein, family 5 DN407_01110 ENOG4108J59 Extracellular solute-binding protein, family 5 DN407_01130 ENOG4105E0C molybdate abc transporter DN407_01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DN407_01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DN407_01150 ENOG4105EGI Transcriptional regulator DN407_01170 ENOG4105F6E Acyl-transferase DN407_01190 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN407_01210 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DN407_01230 ENOG4105C5H ABC transporter DN407_01245 ENOG4105DEF Extracellular solute-binding protein, family 5 DN407_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN407_01260 ENOG4105C3U ABC transporter DN407_01265 ENOG4108JQ7 (ABC) transporter DN407_01270 ENOG410667J hydrolase DN407_01295 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DN407_01300 ENOG4105ERH Fumarylacetoacetate hydrolase DN407_01310 ENOG4105CUB amino acid DN407_01315 ENOG4108SC4 )-transporter DN407_01320 ENOG4105CPF Cell wall formation (By similarity) DN407_01325 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DN407_01350 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DN407_01355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN407_01365 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DN407_01470 ENOG4105K8N protein family UPF0079, ATPase DN407_01475 ENOG41072GX Peptidase M22 Glycoprotease DN407_01480 ENOG410801F ribosomal-protein-alanine acetyltransferase DN407_01485 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DN407_01490 ENOG4105C5H ABC transporter DN407_01505 ENOG4108TYN CAAX amino terminal protease family protein DN407_01525 ENOG4105C7N Xanthine uracil vitamin C permease DN407_01535 ENOG4105BZU Histidine kinase DN407_01585 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN407_01625 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DN407_01655 ENOG4105SX7 Transporter DN407_01685 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DN407_01690 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DN407_01695 ENOG4105C83 adenylosuccinate lyase DN407_01705 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DN407_01730 ENOG4108V3E phosphoribosylglycinamide formyltransferase DN407_01740 ENOG4105C12 Phosphoribosylglycinamide synthetase DN407_01770 ENOG4105C4R Atp-dependent dna helicase DN407_01775 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DN407_01795 ENOG4108W2Y isochorismatase DN407_01805 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DN407_01810 ENOG4108UMI ABC transporter, permease DN407_01815 ENOG4105D01 (LipO)protein DN407_01835 ENOG410834F Transcriptional regulator DN407_01840 ENOG4107I77 yiaA/B two helix domain DN407_01860 ENOG4105CBD Diacylglycerol kinase DN407_01870 ENOG4108JPW Aminotransferase DN407_01880 ENOG4105C26 Dehydrogenase DN407_01885 ENOG4105KPY Small multidrug resistance protein DN407_01910 ENOG4105D9N nucleoside DN407_01915 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DN407_01925 ENOG4108W15 Protein of unknown function (DUF1456) DN407_01945 ENOG4105DTQ mandelate racemase muconate lactonizing DN407_01955 ENOG4105DFD Na H antiporter DN407_01975 ENOG4105D3R alkyl hydroperoxide reductase DN407_01980 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DN407_01985 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DN407_01990 ENOG4107W7X Aldolase DN407_01995 ENOG4105EHG Permease protein DN407_02000 ENOG4105DQ5 transport system permease protein DN407_02005 ENOG4108V5C ABC transporter DN407_02015 ENOG4105CAY ferredoxin--nadp reductase DN407_02035 ENOG4106UIA DN407_02040 ENOG4106UIA DN407_02055 ENOG4105BZU Histidine kinase DN407_02075 ENOG410756H nucleotidyltransferase DN407_02090 ENOG4105D2S major facilitator superfamily DN407_02105 ENOG4105E5Q amino acid AbC transporter DN407_02110 ENOG4105EAB amino acid AbC transporter DN407_02120 ENOG4105C8Q Methyl-accepting chemotaxis DN407_02135 ENOG4105DBV ornithine carbamoyltransferase DN407_02145 ENOG4105C5B carbamate kinase DN407_02150 ENOG4108W63 CRP FNR family transcriptional regulator DN407_02170 ENOG4105CI1 PTS System DN407_02185 ENOG4105C9U ATP-dependent DNA helicase RecQ DN407_02200 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DN407_02220 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN407_02265 ENOG41062JF Transcriptional regulator DN407_02280 ENOG4105DEU major facilitator superfamily DN407_02295 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DN407_02310 ENOG4108N0M stress protein DN407_02315 ENOG4106FN3 tellurium resistance protein DN407_02320 ENOG4106FN3 tellurium resistance protein DN407_02325 ENOG4107TS3 membrane protein, TerC DN407_02330 ENOG4108TTB tellurium resistance protein DN407_02345 ENOG41068PA UPF0435 protein DN407_02350 ENOG4105KJF protein tyrosine phosphatase DN407_02360 ENOG4107U9T Pfam:Ribonuclease_BN DN407_02365 ENOG4105C59 p-type ATPase DN407_02370 ENOG4108IPJ Membrane DN407_02390 ENOG4107ZTW SNARE associated Golgi DN407_02405 ENOG410606W general stress protein DN407_02410 ENOG4105UPD Calcium Proton DN407_02445 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DN407_02450 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN407_02460 ENOG4108JUB Transcriptional regulator DN407_02470 ENOG4108IQI permease DN407_02510 ENOG4108A04 Beta-lactamase DN407_02525 ENOG4105CKK Glycosyl transferase, family 2 DN407_02530 ENOG4107QQG Dehydrogenase DN407_02535 ENOG4105C3I Nad-dependent epimerase dehydratase DN407_02555 ENOG4105F1A Pyruvate formate-lyase DN407_02560 ENOG4108QBV Monogalactosyldiacylglycerol synthase DN407_02575 ENOG4105CI2 imidazolone-5-propionate hydrolase DN407_02580 ENOG4105ECP epimerase DN407_02610 ENOG41067AE Membrane-bound metal-dependent hydrolase DN407_02615 ENOG4105CEN a g-specific adenine glycosylase DN407_02620 ENOG4106BXE DN407_02640 ENOG4105BZ1 (ABC) transporter DN407_02645 ENOG4107NBY Membrane DN407_02650 ENOG4105CBC glutamate synthase DN407_02660 ENOG4108IUW ABC transporter DN407_02680 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN407_02685 ENOG4105G5W regulator Fur family DN407_02795 ENOG4105CDY transcriptional regulatory protein DN407_02805 ENOG4108JQC penicillin-binding protein 1A DN407_02810 ENOG4108R9S DSBA oxidoreductase DN407_02820 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DN407_02830 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DN407_02840 ENOG4105CYN Serine protein kinase DN407_02860 ENOG4105C94 Transporter DN407_02875 ENOG4105DZ6 Band 7 protein DN407_02885 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DN407_02890 ENOG4108V9W transcriptional regulatory protein DN407_02895 ENOG4105D4T Citrate transporter DN407_02920 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN407_02925 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN407_02930 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DN407_02935 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DN407_02940 ENOG4105BZ7 extracellular solute-binding protein family 1 DN407_02945 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DN407_02950 ENOG4108STX response regulator DN407_02955 ENOG4105US7 Histidine kinase DN407_02980 ENOG4108MRH transcriptional regulatory protein DN407_02990 ENOG4105C6K Malic enzyme DN407_03000 ENOG4108UZ3 Transporter DN407_03005 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN407_03015 ENOG4105BZU Histidine kinase DN407_03020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_03025 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN407_03030 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN407_03035 ENOG4108JB9 formate dehydrogenase DN407_03055 ENOG4105CUB amino acid DN407_03070 ENOG4105C59 p-type ATPase DN407_03075 ENOG4105DAP Nicotinate phosphoribosyltransferase DN407_03105 ENOG41073R8 VanW family DN407_03110 ENOG4108KGH TRANSCRIPTIONal DN407_03115 ENOG4105D9N nucleoside DN407_03120 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DN407_03125 ENOG4105C37 (CBS) domain DN407_03130 ENOG4108IJ0 Aspartate ammonia-lyase DN407_03135 ENOG4105DAA L-lactate DN407_03150 ENOG4105DUX Transporter DN407_03155 ENOG4108MES Periplasmic binding protein DN407_03160 ENOG4105DQ5 transport system permease protein DN407_03165 ENOG4108IHU transport system permease protein DN407_03170 ENOG4105E0A ABC, transporter DN407_03175 ENOG4105DMQ Methyltransferase DN407_03180 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DN407_03185 ENOG4105EXW epimerase dehydratase DN407_03195 ENOG4107T89 von Willebrand factor, type A DN407_03200 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DN407_03205 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN407_03215 ENOG4105BZU Histidine kinase DN407_03220 ENOG4105D5Q Arginine ornithine antiporter DN407_03225 ENOG4107414 GntR family transcriptional regulator DN407_03230 ENOG4105C5Y PTS System DN407_03235 ENOG4105CG3 alpha amylase, catalytic region DN407_03250 ENOG4105E1K spore germination protein DN407_03255 ENOG4105CRN Aminoglycoside phosphotransferase DN407_03260 ENOG4105BZG amino acid carrier protein DN407_03270 ENOG4105CDA abc transporter atp-binding protein DN407_03275 ENOG4105CT1 (ABC) transporter DN407_03280 ENOG4105EAD ABC transporter DN407_03285 ENOG4105DRP amino acid AbC transporter DN407_03290 ENOG4108IQI permease DN407_03305 ENOG4105GFR rna polymerase sigma factor DN407_03315 ENOG4105D29 Helix-turn-helix type 11 domain protein DN407_03320 ENOG4105NAE bifunctional deaminase-reductase domain protein DN407_03325 ENOG4105BZU Histidine kinase DN407_03345 ENOG41068KF Universal stress protein DN407_03355 ENOG4105CXY transporter DN407_03360 ENOG41067TZ transcriptional regulator, MarR family DN407_03365 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN407_03370 ENOG4105ETE Transcriptional regulator (LacI family DN407_03375 ENOG4108RVA ribokinase DN407_03385 ENOG4105C2J ABC transporter DN407_03390 ENOG4105CNN ABC, transporter DN407_03395 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DN407_03400 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DN407_03440 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) DN407_03470 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN407_03475 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN407_03480 ENOG41069ER domain protein DN407_03485 ENOG4105VZ8 Transcriptional regulator DN407_03490 ENOG4107D63 DN407_03505 ENOG4105DUX Transporter DN407_03525 ENOG4105C85 amino acid DN407_03530 ENOG4105C7N Xanthine uracil vitamin C permease DN407_03545 ENOG4105MA6 gCN5-related N-acetyltransferase DN407_03565 ENOG4105CCU oxidase (Subunit III) DN407_03570 ENOG4105BZ9 Cytochrome C oxidase, subunit I DN407_03575 ENOG4105E2S oxidase) subunit II DN407_03595 ENOG4106CAD Protein of unknown function (DUF3311) DN407_03600 ENOG4105E1V na solute symporter DN407_03615 ENOG4108NHD germination protein DN407_03620 ENOG4105CE1 Ferrous iron transport protein b DN407_03625 ENOG4105CE1 Ferrous iron transport protein b DN407_03630 ENOG4105CE1 Ferrous iron transport protein b DN407_03635 ENOG4105CVA phosphate DN407_03640 ENOG4105C8U phosphate abc transporter DN407_03645 ENOG4105E2Z phosphate ABC transporter (Permease DN407_03770 ENOG41080XQ Signal transduction protein with cbs domains DN407_03790 ENOG4105ETU transcriptional activator (TenA DN407_03800 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN407_03810 ENOG4108VEU Thiamine monophosphate synthase DN407_03815 ENOG41080HI glycine oxidase DN407_03830 ENOG4105D06 uba thif-type nad fad binding protein DN407_03835 ENOG4105DWF phosphomethylpyrimidine kinase DN407_03885 ENOG4108INS Transcriptional regulator DN407_03910 ENOG4105C19 ABC transporter DN407_03920 ENOG4105C7N Xanthine uracil vitamin C permease DN407_03930 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN407_03945 ENOG4105K63 Thioredoxin DN407_03965 ENOG4108B31 Spore germination protein DN407_03985 ENOG4107Y03 Nitroreductase DN407_03990 ENOG4105ED1 spovr family DN407_04000 ENOG4108TCS Glutamyl endopeptidase DN407_04010 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DN407_04015 ENOG4105XTG Pfam:DUF156 DN407_04020 ENOG4105VFE sira family DN407_04025 ENOG4107TPS domain protein DN407_04030 ENOG4105VFE sira family DN407_04035 ENOG4105VFE sira family DN407_04045 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DN407_04050 ENOG41087NI Sulfite exporter TauE/SafE DN407_04060 ENOG4108KGH TRANSCRIPTIONal DN407_04090 ENOG4105EMD TRANSCRIPTIONal DN407_04095 ENOG4105VCP PTS System DN407_04100 ENOG4105VZJ PTS System DN407_04125 ENOG41069ER domain protein DN407_04130 ENOG4107RBB ABC transporter, permease DN407_04135 ENOG4105C19 ABC transporter DN407_04165 ENOG4105WEF catalase DN407_04200 ENOG4107T5V SNARE associated Golgi DN407_04230 ENOG4105CUB amino acid DN407_04235 ENOG4107RWR Sodium hydrogen exchanger DN407_04245 ENOG4106KNT transcriptional regulator DN407_04285 ENOG4108YXU transcriptional regulator AsnC family DN407_04290 ENOG4105CH7 arginosuccinase DN407_04295 ENOG4105UBK short-chain dehydrogenase reductase DN407_04305 ENOG4105KPY Small multidrug resistance protein DN407_04340 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN407_04345 ENOG4105E5W Transporter DN407_04355 ENOG4107RKG DJ-1/PfpI family DN407_04360 ENOG4105CH6 catalase DN407_04370 ENOG4105D5Q Arginine ornithine antiporter DN407_04375 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DN407_04385 ENOG4105C26 Dehydrogenase DN407_04400 ENOG4105BZ1 (ABC) transporter DN407_04405 ENOG4105BZ1 (ABC) transporter DN407_04420 ENOG4105DRP amino acid AbC transporter DN407_04425 ENOG4105CDA abc transporter atp-binding protein DN407_04440 ENOG410839P DN407_04475 ENOG4107FQX Alpha-acetolactate decarboxylase DN407_04485 ENOG4108VX5 3-methyladenine DNA glycosylase DN407_04500 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN407_04505 ENOG4105D4P Coproporphyrinogen iii oxidase DN407_04510 ENOG4105CEY Amp-dependent synthetase and ligase DN407_04525 ENOG4105CHH sulfate transporter DN407_04555 ENOG4105CGU Enoyl-CoA hydratase DN407_04575 ENOG4105DER m42 family DN407_04600 ENOG4105CIF Ornithine Cyclodeaminase DN407_04620 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN407_04625 ENOG4105C3U ABC transporter DN407_04630 ENOG4108JQ7 (ABC) transporter DN407_04680 ENOG4105CSH Transporter DN407_04690 ENOG4108MRH transcriptional regulatory protein DN407_04720 ENOG4105D7A ATP-binding protein DN407_04730 ENOG4105EYH Exonuclease DN407_04740 ENOG4105C3J Cysteine desulfurase DN407_04790 ENOG4105CDU Replicative dna helicase DN407_04815 ENOG4108Z86 Glutamine amidotransferase DN407_04830 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN407_04850 ENOG4105D9U N-acetyltransferase DN407_04915 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN407_04935 ENOG4105CMT Dihydroxyacetone kinase DN407_04950 ENOG4105CMT Dihydroxyacetone kinase DN407_05050 ENOG4105WN5 stage II sporulation protein DN407_05060 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN407_05070 ENOG4108MJI response regulator DN407_05075 ENOG4105BZU Histidine kinase DN407_05080 ENOG4105BZU Histidine kinase DN407_05100 ENOG4105K8R UPF0145 protein DN407_05120 ENOG4107QHE Choloylglycine hydrolase DN407_05140 ENOG4107VRP DNA repair exonuclease DN407_05145 ENOG4106D4I domain protein DN407_05155 ENOG4105ED2 Beta-lactamase DN407_05200 ENOG4108MUZ hydrolase DN407_05220 ENOG4105F0F Oxalate decarboxylase DN407_05225 ENOG41067QW Transcriptional regulator DN407_05230 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN407_05245 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DN407_05260 ENOG4105EMN RNA polymerase sigma factor DN407_05270 ENOG4105CNI cell division protein FtsW DN407_05275 ENOG4105EEM helicase DN407_05280 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN407_05310 ENOG4105K59 histidine triad (HIT) protein DN407_05340 ENOG410905X membrane-flanked domain protein DN407_05345 ENOG4105CKV Membrane DN407_05385 ENOG410905X membrane-flanked domain protein DN407_05390 ENOG4105CKV Membrane DN407_05395 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DN407_05400 ENOG4105BZ4 penicillin-binding protein DN407_05410 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DN407_05415 ENOG4105C1Q protoporphyrinogen oxidase DN407_05440 ENOG4105NA0 Transcriptional regulator DN407_05455 ENOG4105ECB domain protein DN407_05455 ENOG4105ECB domain protein DN407_05485 ENOG4106AXD DN407_05490 ENOG4108RQ5 Beta-lactamase domain-containing protein DN407_05495 ENOG4105DF9 Lipoate-protein, ligase DN407_05505 ENOG4105CEY Amp-dependent synthetase and ligase DN407_05515 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DN407_05520 ENOG4108I5D sulfate abc transporter DN407_05525 ENOG4105ECW sulfate abc transporter DN407_05530 ENOG4108IJ6 ABC transporter DN407_05535 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DN407_05545 ENOG4107RN3 metallophosphoesterase DN407_05550 ENOG4107TVP HD domain protein DN407_05560 ENOG4108AEY RNA polymerase sigma factor DN407_05570 ENOG41086D8 Transcriptional regulator DN407_05585 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN407_05605 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DN407_05610 ENOG4105C8Q Methyl-accepting chemotaxis DN407_05615 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) DN407_05625 ENOG4107QP3 malate synthase g DN407_05645 ENOG4105VEQ Cold shock protein DN407_05725 ENOG4105ERH Fumarylacetoacetate hydrolase DN407_05735 ENOG4105C8Y Acetylornithine aminotransferase DN407_05750 ENOG4105CAQ asparagine synthetase DN407_05755 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DN407_05760 ENOG4105CH6 catalase DN407_05800 ENOG4105BZU Histidine kinase DN407_05815 ENOG4108VPT UPF0234 protein DN407_05820 ENOG4105QNR S1 RNA binding domain protein DN407_05825 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN407_05835 ENOG4107AYK membrAne DN407_05840 ENOG41073B9 DN407_05850 ENOG4108KP7 hydrolase DN407_05860 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DN407_05885 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DN407_05890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DN407_05905 ENOG4105C31 Tryptophanyl-tRNA synthetase DN407_05920 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN407_05925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN407_05935 ENOG4108JQ7 (ABC) transporter DN407_05940 ENOG4105UQX Mate efflux family protein DN407_05960 ENOG4108ZCF integral membrane protein DN407_05970 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN407_05980 ENOG4105DPN Oligoendopeptidase f DN407_05990 ENOG4108Z18 K06886 hemoglobin DN407_05995 ENOG4105MIX Adenylate cyclase DN407_06000 ENOG4106EFP UPF0738 protein DN407_06010 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DN407_06015 ENOG4105EMS pseudouridine synthase DN407_06035 ENOG4105K64 Glycosyl transferase, family 2 DN407_06055 ENOG4107TVC Glycosyl transferase, family 2 DN407_06075 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DN407_06080 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DN407_06090 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DN407_06140 ENOG4108ZMI UPF0477 protein DN407_06170 ENOG4105CK7 Sodium proline symporter DN407_06180 ENOG4105CRQ synthase (Component I) DN407_06185 ENOG4105DDQ anthranilate synthase DN407_06195 ENOG4105DK0 Indole-3-glycerol phosphate synthase DN407_06280 ENOG4105C7S Dehydrogenase DN407_06285 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DN407_06335 ENOG4105DZ1 carboxypeptidase DN407_06340 ENOG4105VFR signal peptidase DN407_06375 ENOG4105C26 Dehydrogenase DN407_06380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN407_06385 ENOG4105F38 ABC transporter, permease DN407_06390 ENOG4105D38 putrescine abc transporter DN407_06395 ENOG4107RUE extracellular solute-binding protein family 1 DN407_06405 ENOG4105EYF MMPL domain protein DN407_06415 ENOG4108YBP pseudouridine synthase DN407_06425 ENOG4105K4I Scp-like extracellular DN407_06430 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DN407_06435 ENOG4105CQB FAD linked oxidase domain protein DN407_06450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_06455 ENOG4105BZU Histidine kinase DN407_06460 ENOG4105JXH GntR family transcriptional regulator DN407_06480 ENOG4106A3R peptidase DN407_06490 ENOG4108QTI )-transporter DN407_06495 ENOG4107TS3 membrane protein, TerC DN407_06500 ENOG4105CZN Potassium uptake protein DN407_06505 ENOG410681C small acid-soluble spore protein DN407_06510 ENOG4108Z7G MaoC domain protein dehydratase DN407_06530 ENOG4105CHR reductase DN407_06560 ENOG4105C4Y ABC transporter DN407_06565 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN407_06570 ENOG4107RCV ABC transporter, permease DN407_06590 ENOG4105E98 transcriptional regulator DeoR family DN407_06600 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DN407_06610 ENOG4105PXI polysaccharide deacetylase DN407_06620 ENOG4105BZU Histidine kinase DN407_06625 ENOG41090MY MarR family Transcriptional regulator DN407_06635 ENOG4106DF1 DN407_06640 ENOG4105BZU Histidine kinase DN407_06645 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DN407_06650 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DN407_06655 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DN407_06695 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DN407_06700 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DN407_06705 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DN407_06710 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN407_06715 ENOG4105CZV ABC transporter DN407_06725 ENOG4105CJ1 ABC, transporter DN407_06765 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DN407_06770 ENOG4105EA8 2-Nitropropane dioxygenase DN407_06775 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN407_06785 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DN407_06810 ENOG4105NQC Flavodoxin DN407_06865 ENOG4105CZN Potassium uptake protein DN407_06870 ENOG41063Y9 DN407_06875 ENOG4105KBJ sporulation protein ytfj DN407_06895 ENOG4105CM2 brancheD-chain amino acid aminotransferase DN407_06900 ENOG4105C7K acetolactate synthase DN407_06905 ENOG4108ZP8 Acetolactate synthase small subunit DN407_06910 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DN407_06925 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DN407_06945 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DN407_06955 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DN407_06960 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DN407_06965 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DN407_06980 ENOG4107RVV histidinol phosphate phosphatase, hisj family DN407_06995 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN407_07000 ENOG4105E0M Sulfatase DN407_07010 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DN407_07025 ENOG4107S4M Sulfate adenylate transferase DN407_07030 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DN407_07035 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DN407_07045 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN407_07050 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN407_07055 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN407_07060 ENOG4105C8J )-transporter DN407_07080 ENOG4105DFD Na H antiporter DN407_07100 ENOG4105ENE Histidine kinase DN407_07105 ENOG4105WH1 Two component transcriptional regulator luxr family DN407_07125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN407_07150 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DN407_07170 ENOG4105CJ3 phosphate transporter DN407_07175 ENOG4107GRR phosphate transport regulator DN407_07180 ENOG4105BZ4 penicillin-binding protein DN407_07195 ENOG4105BZU Histidine kinase DN407_07200 ENOG4105I3N Conserved Protein DN407_07215 ENOG4105BZU Histidine kinase DN407_07250 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN407_07255 ENOG4105DZ1 carboxypeptidase DN407_07260 ENOG4108JIC nucleoside recognition domain protein DN407_07270 ENOG4105FE9 pseudouridine synthase DN407_07275 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN407_07280 ENOG4107TWT Cytochrome c biogenesis protein DN407_07285 ENOG4105CRE cytochrome C DN407_07290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_07295 ENOG4105BZU Histidine kinase DN407_07300 ENOG4108WBT adenosyltransferase DN407_07315 ENOG4108SAX Membrane DN407_07330 ENOG4105C9U ATP-dependent DNA helicase RecQ DN407_07335 ENOG4105I7S Abortive infection protein DN407_07345 ENOG4107RGJ metallophosphoesterase DN407_07350 ENOG4108XDN Transcriptional regulator DN407_07355 ENOG4108S6Z Negative regulator of genetic competence DN407_07380 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DN407_07385 ENOG4107RB3 L-asparaginase DN407_07400 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DN407_07415 ENOG4105S2F DN407_07420 ENOG41065D1 DN407_07450 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DN407_07465 ENOG4105XXQ heptaprenyl diphosphate synthase component I DN407_07475 ENOG4105EAH synthase DN407_07480 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DN407_07485 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN407_07500 ENOG41068YB TPR repeat-containing protein DN407_07515 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DN407_07520 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DN407_07555 ENOG4108JYZ YitT family DN407_07565 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DN407_07580 ENOG4105FJR Lmbe family DN407_07585 ENOG4105CPK Glycosyl transferase (Group 1 DN407_07610 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DN407_07625 ENOG4105DVT helicase DN407_07630 ENOG4105YAC DN407_07650 ENOG4105CSM endonuclease III DN407_07660 ENOG4105BZ4 penicillin-binding protein DN407_07700 ENOG4106F55 Protein of unknown function (DUF1273) DN407_07715 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DN407_07725 ENOG4105DVT helicase DN407_07730 ENOG4105CTD carboxy-peptidase DN407_07740 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN407_07745 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DN407_07750 ENOG4105C2W permease DN407_07755 ENOG4105DHF Membrane DN407_07760 ENOG410890F Dynamin family DN407_07770 ENOG4108W0I acetyltransferase DN407_07780 ENOG4105KHC sulfurtransferase DN407_07840 ENOG4105HTX biosynthesis protein DN407_07870 ENOG4105CPK Glycosyl transferase (Group 1 DN407_07885 ENOG4108SZE gCN5-related N-acetyltransferase DN407_07905 ENOG41081VK Ribonuclease DN407_07970 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN407_07980 ENOG4107RWR Sodium hydrogen exchanger DN407_07985 ENOG4105CN5 Metallo-Beta-Lactamase DN407_07990 ENOG4108Z5V transcriptional regulator, merr family DN407_08000 ENOG4105H67 Protein of unknown function (DUF421) DN407_08005 ENOG41080C8 DUF218 domain DN407_08045 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DN407_08055 ENOG4107R0U MotA TolQ exbB proton channel DN407_08060 ENOG4105ER2 Ompa motb domain protein DN407_08065 ENOG4107YTP response regulator receiver protein DN407_08070 ENOG4105CBS Chea signal transduction histidine kinase DN407_08075 ENOG4105DD5 Flagellar motor switch protein DN407_08090 ENOG4105BZU Histidine kinase DN407_08110 ENOG4105E1Q flagellar hook-associated protein DN407_08115 ENOG4105DTJ flagellar hook-associated protein DN407_08135 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DN407_08140 ENOG4108ZC9 flagellar basal-body rod protein flgc DN407_08145 ENOG41075Z6 flagellar hook-basal body complex protein fliE DN407_08150 ENOG4107U2N Flagellar M-ring protein DN407_08155 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN407_08185 ENOG4105BZE flagellar hook protein, FlgE DN407_08200 ENOG4107R88 Chemotaxis protein (CheV) DN407_08215 ENOG4105I03 Flagellin DN407_08220 ENOG4105I03 Flagellin DN407_08225 ENOG4105I03 Flagellin DN407_08230 ENOG4105I03 Flagellin DN407_08235 ENOG4105E4C Lytic transglycosylase catalytic DN407_08245 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN407_08250 ENOG4105DD5 Flagellar motor switch protein DN407_08260 ENOG4105CN7 Flagellar biosynthetic protein FliP DN407_08265 ENOG4105VS8 Flagellar biosynthetic protein fliq DN407_08275 ENOG4105D00 flagellar biosynthetic protein flhB DN407_08280 ENOG4105D7B Flagellar biosynthesis protein flha DN407_08285 ENOG4105FZW flagellar biosynthesis regulator FlhF DN407_08290 ENOG4105KTQ flagellar basal-body rod protein DN407_08295 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN407_08330 ENOG4105KAC Antibiotic biosynthesis monooxygenase DN407_08355 ENOG4105DUM transcriptional regulator, lysR family DN407_08360 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN407_08365 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DN407_08370 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DN407_08415 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DN407_08435 ENOG4105CAQ asparagine synthetase DN407_08455 ENOG4105PGM cation diffusion facilitator family transporter DN407_08465 ENOG4105DRR Transcriptional regulator, GntR family DN407_08470 ENOG4108UZ3 Transporter DN407_08480 ENOG4105CKI cobalamin synthesis protein DN407_08490 ENOG4108PJD permease DN407_08505 ENOG4105DFD Na H antiporter DN407_08510 ENOG4105VUF Transcriptional regulator DN407_08520 ENOG4105C9Q fumarate hydratase class II DN407_08535 ENOG4107QJQ Mate efflux family protein DN407_08540 ENOG4105EC3 peptidase S51, dipeptidase E DN407_08560 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN407_08570 ENOG4107JM4 Tetratricopeptide repeat DN407_08590 ENOG4106BRA Membrane DN407_08630 ENOG4105CJ1 ABC, transporter DN407_08655 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DN407_08665 ENOG4108IJ0 Aspartate ammonia-lyase DN407_08670 ENOG4105C6K Malic enzyme DN407_08730 ENOG4105FVX DN407_08735 ENOG4105E09 nadh pyrophosphatase DN407_08755 ENOG4105CSR polyphosphate kinase 2 DN407_08760 ENOG4105U3E Transcriptional regulator DN407_08770 ENOG4105DXI Major Facilitator superfamily DN407_08780 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN407_08785 ENOG4105EU0 Major facilitator Superfamily DN407_08790 ENOG4105C6T cysteine synthase DN407_08810 ENOG4105C8J )-transporter DN407_08815 ENOG4105X5K response regulator receiver protein DN407_08820 ENOG4105H67 Protein of unknown function (DUF421) DN407_08845 ENOG4105CHR reductase DN407_08850 ENOG4105CM2 brancheD-chain amino acid aminotransferase DN407_08855 ENOG4105C7K acetolactate synthase DN407_08865 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DN407_08870 ENOG4105C01 Dihydroxy-acid dehydratase DN407_08875 ENOG4105C7B Threonine dehydratase DN407_08900 ENOG4105C6X Major Facilitator DN407_08905 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DN407_08915 ENOG4105DY9 regulatoR DN407_08920 ENOG4105CYC Transferase DN407_08925 ENOG4105K5X acetyltransferase DN407_08945 ENOG41068WN DN407_08950 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DN407_08965 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DN407_08970 ENOG4105C0X amino acid DN407_08995 ENOG4105K8R UPF0145 protein DN407_09010 ENOG4107RHR regulatoR DN407_09020 ENOG4105D9N nucleoside DN407_09025 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DN407_09065 ENOG4107RAQ aminopeptidase DN407_09075 ENOG4107R16 Multicopper oxidase DN407_09125 ENOG4108T5E Copper resistance protein DN407_09130 ENOG4105KTB nuclear export factor GLE1 DN407_09135 ENOG4107RT3 EamA-like transporter family DN407_09140 ENOG4105GZI Transcriptional regulator DN407_09145 ENOG4108Z40 Transcriptional regulator DN407_09150 ENOG4107ZXU DSBA oxidoreductase DN407_09155 ENOG4108TVJ Nitroreductase DN407_09160 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN407_09165 ENOG4106F5Q Membrane DN407_09170 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN407_09185 ENOG4105CKI cobalamin synthesis protein DN407_09195 ENOG4105C0Z ABC transporter DN407_09200 ENOG4108IV0 ABC, transporter DN407_09205 ENOG4105C32 Amino acid ABC transporter (Permease) DN407_09215 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family DN407_09225 ENOG41090U3 tautomerase DN407_09240 ENOG4105C4M (Ubiquinol oxidase) subunit I DN407_09245 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN407_09250 ENOG4108JJ9 ABC, transporter DN407_09255 ENOG4108JJ8 (ABC) transporter DN407_09265 ENOG4105K64 Glycosyl transferase, family 2 DN407_09275 ENOG4108UT6 Transferase hexapeptide repeat containing protein DN407_09330 ENOG4105BZ1 (ABC) transporter DN407_09335 ENOG4105EFI regulatoR DN407_09340 ENOG4105BZU Histidine kinase DN407_09350 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DN407_09355 ENOG4108ZJ4 polysaccharide deacetylase DN407_09375 ENOG4105D6E homoserine dehydrogenase DN407_09385 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DN407_09400 ENOG4108KGH TRANSCRIPTIONal DN407_09410 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN407_09415 ENOG4105BZU Histidine kinase DN407_09420 ENOG4107VMI polysaccharide deacetylase DN407_09430 ENOG4105KT7 mgtC SapB transporter DN407_09435 ENOG4105VRR gCN5-related N-acetyltransferase DN407_09445 ENOG4105DUU IucA IucC family protein DN407_09450 ENOG4105CEY Amp-dependent synthetase and ligase DN407_09465 ENOG4108WBH protein TIM barrel DN407_09470 ENOG4105YWU small acid-soluble spore protein DN407_09480 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DN407_09485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN407_09535 ENOG4105KRN Transcriptional regulator, abrb family DN407_09575 ENOG4105C8Q Methyl-accepting chemotaxis DN407_09590 ENOG4108K88 Membrane DN407_09595 ENOG4108WPJ Ferritin-like domain DN407_09610 ENOG4105DEN Luciferase family DN407_09625 ENOG4105VMI -acetyltransferase DN407_09630 ENOG4107QM2 Aldo Keto reductase DN407_09635 ENOG4105CKI cobalamin synthesis protein DN407_09645 ENOG4105DSE periplasmic solute binding protein DN407_09650 ENOG4105K4T epimerase DN407_09660 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN407_09705 ENOG4107T5V SNARE associated Golgi DN407_09720 ENOG4108PJD permease DN407_09730 ENOG4108S4H thioesterase Superfamily protein DN407_09740 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN407_09760 ENOG4105SXS Protein of unknown function (DUF456) DN407_09765 ENOG4105C37 (CBS) domain DN407_09785 ENOG4108Z7R Chaperone CsaA DN407_09805 ENOG4108ZRV stage ii sporulation protein p DN407_09815 ENOG4108VXD carboxy-peptidase DN407_09845 ENOG4108ZRV stage ii sporulation protein p DN407_09855 ENOG4108X4Q Hydrolase DN407_09870 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN407_09890 ENOG41087PP glycosyltransferase MGT family DN407_09895 ENOG4108JYZ YitT family DN407_09900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN407_09930 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN407_09950 ENOG4106PAW secretion accessory protein EsaA YueB DN407_09960 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) DN407_09965 ENOG4108MGT Required for secretion of EsxA and EsxB DN407_10040 ENOG4105KBJ sporulation protein ytfj DN407_10065 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN407_10085 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DN407_10090 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DN407_10100 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DN407_10105 ENOG4105EMN RNA polymerase sigma factor DN407_10130 ENOG4108V06 Glutathione peroxidase DN407_10145 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN407_10155 ENOG4108IUE nitrate reductase beta subunit DN407_10160 ENOG4105R3A Nitrate reductase DN407_10170 ENOG4107V6Q Cyclic nucleotide-binding domain DN407_10175 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN407_10180 ENOG4105D06 uba thif-type nad fad binding protein DN407_10185 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN407_10190 ENOG4108ZAF Molybdopterin DN407_10195 ENOG41067WU Molybdopterin converting factor (Subunit 1) DN407_10225 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN407_10230 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN407_10235 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN407_10240 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DN407_10245 ENOG4108IFG nitrite reductase, (NAD(P)H) DN407_10250 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DN407_10285 ENOG4105MCT stage V sporulation protein S DN407_10325 ENOG4105C5H ABC transporter DN407_10340 ENOG4108UUM single-stranded DNA-binding protein DN407_10365 ENOG4107YX5 Pfam:DUF548 DN407_10370 ENOG4105C75 arginyL-tRNA synthetase DN407_10395 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN407_10425 ENOG4105C5S asparaginyl-tRNA synthetase DN407_10430 ENOG4105C8J )-transporter DN407_10450 ENOG4107XGZ Hydrolase DN407_10455 ENOG4105CY2 Citrate transporter DN407_10475 ENOG4105KD7 acetyltransferase DN407_10485 ENOG4105VMP Transcriptional regulator DN407_10490 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DN407_10515 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DN407_10530 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DN407_10535 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DN407_10545 ENOG4107RVG penicillin-binding protein DN407_10550 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DN407_10555 ENOG4105E9Q Acyl-transferase DN407_10560 ENOG4108UT2 hemolysin iii DN407_10570 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DN407_10580 ENOG4108RCR degv family DN407_10590 ENOG4108KF3 Electron transport protein SCO1 SenC DN407_10595 ENOG4107Y70 Heat shock protein DN407_10600 ENOG4105CAQ asparagine synthetase DN407_10615 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN407_10620 ENOG4108MES Periplasmic binding protein DN407_10625 ENOG4105F0I Aminotransferase DN407_10660 ENOG4105D8X mechanosensitive ion channel DN407_10665 ENOG4105BZU Histidine kinase DN407_10670 ENOG4105WH1 Two component transcriptional regulator luxr family DN407_10675 ENOG4106KNT transcriptional regulator DN407_10680 ENOG4107ZY0 Phenazine biosynthesis-like protein DN407_10700 ENOG4105CMG Carbohydrate kinase DN407_10705 ENOG4105C6Z Gluconate DN407_10745 ENOG4108IJ8 ABC transporter DN407_10750 ENOG4105E90 ABC transporter DN407_10785 ENOG4105C37 (CBS) domain DN407_10810 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN407_10825 ENOG4107S4Y M20 DapE family protein YgeY DN407_10830 ENOG4108TSC N-acetyltransferase DN407_10835 ENOG4108JUB Transcriptional regulator DN407_10840 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DN407_10885 ENOG410841Q phosphoesterase PA-phosphatase related protein DN407_10895 ENOG4105SZ6 Thioredoxin DN407_10930 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN407_10985 ENOG4105BZ4 penicillin-binding protein DN407_10995 ENOG4105CZM Major Facilitator DN407_11000 ENOG4105W8X HesB YadR YfhF-family protein DN407_11010 ENOG4105DXD 2-methylcitrate dehydratase DN407_11015 ENOG4105CR4 methylisocitrate lyase DN407_11020 ENOG4105C1G acyl-Coa dehydrogenase DN407_11025 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN407_11035 ENOG4105N14 lysine exporter protein LysE YggA DN407_11040 ENOG4105E39 Enoyl-CoA hydratase DN407_11055 ENOG4107RFY SbcCD D subunit DN407_11060 ENOG4105EYH Exonuclease DN407_11075 ENOG4105FCD Major Facilitator DN407_11080 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DN407_11085 ENOG4105E4F Isochorismate synthase DN407_11090 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DN407_11095 ENOG4105WQI isochorismatase DN407_11100 ENOG4105CEY Amp-dependent synthetase and ligase DN407_11105 ENOG4105WQT MbtH domain protein DN407_11110 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN407_11125 ENOG4105K70 DNA-binding protein DN407_11145 ENOG4105BZG amino acid carrier protein DN407_11165 ENOG4105FE9 pseudouridine synthase DN407_11170 ENOG4105C22 threonyL-tRNA synthetase DN407_11175 ENOG4105C19 ABC transporter DN407_11220 ENOG41081I9 integral membrane protein DN407_11230 ENOG4108Y4K DNA-binding transcriptional activator DN407_11260 ENOG4105EYF MMPL domain protein DN407_11285 ENOG4105WCN acetyltransferase DN407_11310 ENOG4105C1Q protoporphyrinogen oxidase DN407_11320 ENOG41068WN DN407_11350 ENOG4107V2S Transcriptional regulator DN407_11355 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN407_11375 ENOG4105DND Transcriptional regulator DN407_11380 ENOG4108RPX mosc domain containing protein DN407_11395 ENOG4105BZ1 (ABC) transporter DN407_11400 ENOG4105BZ1 (ABC) transporter DN407_11430 ENOG4108JCI Transcriptional regulator DN407_11490 ENOG4105F32 YngK protein DN407_11515 ENOG4105RD7 BadF BadG BcrA BcrD DN407_11520 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DN407_11525 ENOG4107STF Involved in phosphonate degradation (By similarity) DN407_11530 ENOG4105C7B Threonine dehydratase DN407_11535 ENOG4108INS Transcriptional regulator DN407_11550 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DN407_11555 ENOG4105C1J atp-dependent rna helicase DN407_11565 ENOG4108RZE Tetr family transcriptional regulator DN407_11585 ENOG41088CC tellurite resistance protein tehB DN407_11595 ENOG4108I0C methyltransferase DN407_11600 ENOG4107RA9 decarboxylase DN407_11605 ENOG4105K56 Transcriptional regulator DN407_11610 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DN407_11635 ENOG4105CIN aminoacyl-histidine dipeptidase DN407_11660 ENOG4105KRN Transcriptional regulator, abrb family DN407_11670 ENOG4105EJ9 Membrane DN407_11675 ENOG4105EQK -acetyltransferase DN407_11775 ENOG4108IMY Transcriptional regulator DN407_11790 ENOG4107VMI polysaccharide deacetylase DN407_11795 ENOG4108RZE Tetr family transcriptional regulator DN407_11800 ENOG4105CAQ asparagine synthetase DN407_11805 ENOG4108XG2 Histidine kinase DN407_11815 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DN407_11850 ENOG4105EJQ L-serine dehydratase DN407_11855 ENOG4105C44 Serine transporter DN407_11885 ENOG4105CVK Glutamate decarboxylase DN407_11910 ENOG4107RVG penicillin-binding protein DN407_11925 ENOG4107RF6 penicillin-binding protein DN407_11930 ENOG4107RF6 penicillin-binding protein DN407_11940 ENOG4105DIN metallophosphoesterase DN407_11950 ENOG4105CJ1 ABC, transporter DN407_11960 ENOG4107Z3H Transcriptional regulator, TetR family DN407_11975 ENOG4105C1G acyl-Coa dehydrogenase DN407_11980 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN407_11985 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DN407_11990 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DN407_11995 ENOG4105E39 Enoyl-CoA hydratase DN407_12000 ENOG4107QX3 carboxylase DN407_12005 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN407_12055 ENOG4105DZ1 carboxypeptidase DN407_12070 ENOG4105T9C HD domain DN407_12080 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DN407_12100 ENOG41075H3 AraC family transcriptional regulator DN407_12135 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DN407_12140 ENOG4105KVH Transcriptional regulator DN407_12155 ENOG4105MDS 4-oxalocrotonate tautomerase DN407_12160 ENOG4107V2S Transcriptional regulator DN407_12210 ENOG4105EFA 4-hydroxyphenylacetate DN407_12235 ENOG410900G Protein of unknown function (DUF421) DN407_12240 ENOG4108V4B ThiJ pfpI DN407_12250 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DN407_12320 ENOG4105D6E homoserine dehydrogenase DN407_12330 ENOG4105CPF Cell wall formation (By similarity) DN407_12335 ENOG4105ETU transcriptional activator (TenA DN407_12365 ENOG4105VTR Integrase DN407_12420 ENOG4108NF7 phage-type endonuclease DN407_12425 ENOG4108PNI recT protein DN407_12450 ENOG4108SXZ UPF0302 protein DN407_12540 ENOG4108TFU terminase (Small subunit) DN407_12640 ENOG4105XSJ toxin secretion phage lysis holin DN407_12780 ENOG410667J hydrolase DN407_12785 ENOG4105BZU Histidine kinase DN407_12790 ENOG4107RF6 penicillin-binding protein DN407_12815 ENOG4108JJB ABC transporter DN407_12830 ENOG4108HGU Histidine kinase DN407_12910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_12915 ENOG4105GR3 Histidine kinase DN407_12920 ENOG4105CB2 alcohol dehydrogenase DN407_12925 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DN407_12930 ENOG4105CJN penicillin-binding protein DN407_12985 ENOG4108V4B ThiJ pfpI DN407_13000 ENOG4105F27 Major Facilitator DN407_13005 ENOG4107Y80 Major Facilitator superfamily DN407_13020 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DN407_13040 ENOG4107Y9U Membrane DN407_13060 ENOG4105EGD dinuclear metal center protein, YbgI family DN407_13065 ENOG4105M6F mutator MutT protein DN407_13080 ENOG4105FCD Major Facilitator DN407_13090 ENOG4105E09 nadh pyrophosphatase DN407_13095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN407_13115 ENOG4108XI2 Domain of unknown function (DUF1963) DN407_13140 ENOG4108NRW Phospholipase, patatin family DN407_13145 ENOG4105KWG Pfam:DUF1696 DN407_13155 ENOG4108YYS metal-dependent hydrolase (By similarity) DN407_13170 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN407_13180 ENOG4105PKS Excinuclease abc c subunit domain protein DN407_13220 ENOG4107VFR oxidoreductase DN407_13250 ENOG4105U0R haloacid dehalogenase-like hydrolase DN407_13255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_13260 ENOG4105BZU Histidine kinase DN407_13280 ENOG4107WD8 ABC transporter, permease DN407_13295 ENOG4105DY8 decarboxylase DN407_13310 ENOG4108IUM Glycogen debranching enzyme DN407_13320 ENOG4105CGH 5'-nucleotidase DN407_13335 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN407_13340 ENOG4105FDR Membrane DN407_13395 ENOG4105MSI germination protein ypeb DN407_13425 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DN407_13430 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DN407_13435 ENOG4107Z3H Transcriptional regulator, TetR family DN407_13480 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DN407_13495 ENOG4105E98 transcriptional regulator DeoR family DN407_13510 ENOG41062ES Transcriptional regulator DN407_13530 ENOG4107QKR Dehydrogenase DN407_13540 ENOG4107RUY (E1 component), alpha subunit DN407_13550 ENOG4105JHE Major Facilitator Superfamily DN407_13560 ENOG4105E1F short-chain dehydrogenase reductase DN407_13590 ENOG4107SQ8 Glycine betaine DN407_13595 ENOG4108IJ7 Glycine betaine DN407_13620 ENOG4105E66 phosphoriboisomerase A DN407_13625 ENOG41082BV acetyltransferase DN407_13630 ENOG4108M1A Chitin-binding protein DN407_13635 ENOG41087PP glycosyltransferase MGT family DN407_13660 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN407_13665 ENOG4105MSB protein, conserved in bacteria DN407_13690 ENOG4108Z7F N-acetyltransferase DN407_13710 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DN407_13715 ENOG4105EEM helicase DN407_13730 ENOG4105C9U ATP-dependent DNA helicase RecQ DN407_13775 ENOG4108M1A Chitin-binding protein DN407_13790 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DN407_13800 ENOG4105BZG amino acid carrier protein DN407_13805 ENOG4105C26 Dehydrogenase DN407_13810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN407_13815 ENOG4105CTU Proline racemase DN407_13820 ENOG4105CTU Proline racemase DN407_13825 ENOG41080HI glycine oxidase DN407_13835 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DN407_13865 ENOG4107T5V SNARE associated Golgi DN407_13875 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN407_13895 ENOG4105DTQ mandelate racemase muconate lactonizing DN407_13910 ENOG4107SET aldo keto reductase DN407_13945 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DN407_13950 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN407_13955 ENOG4105BZU Histidine kinase DN407_13960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_13980 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 DN407_14000 ENOG4105DPN Oligoendopeptidase f DN407_14005 ENOG4105EPR degv family DN407_14065 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN407_14070 ENOG4106K7D Major facilitator family transporter DN407_14095 ENOG4107BMA Transglycosylase associated protein DN407_14110 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DN407_14145 ENOG4105CHM Aminotransferase DN407_14160 ENOG4108ZMI UPF0477 protein DN407_14175 ENOG4105DVE abc transporter atp-binding protein DN407_14225 ENOG4105C02 permease DN407_14235 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DN407_14240 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DN407_14245 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DN407_14250 ENOG4105D7T ABC transporter DN407_14275 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DN407_14325 ENOG4107VC0 DNA alkylation repair enzyme DN407_14330 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DN407_14340 ENOG4107VMI polysaccharide deacetylase DN407_14345 ENOG4108ZCF integral membrane protein DN407_14350 ENOG4105E0M Sulfatase DN407_14355 ENOG4105C5H ABC transporter DN407_14360 ENOG4105EYF MMPL domain protein DN407_14365 ENOG41082JN Transcriptional regulator DN407_14390 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN407_14395 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN407_14450 ENOG41069ER domain protein DN407_14460 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DN407_14465 ENOG4105DNP FAD linked oxidase domain protein DN407_14495 ENOG4105D4B ABC, transporter DN407_14500 ENOG4105F5R ABC transporter DN407_14505 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DN407_14515 ENOG4105DKT Transcriptional regulator DN407_14520 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DN407_14530 ENOG41061GT Aldolase DN407_14540 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DN407_14575 ENOG4105II7 pyrroline-5-carboxylate reductase DN407_14585 ENOG4107258 Transcriptional regulator DN407_14610 ENOG4105ECK Fatty Acid Desaturase DN407_14620 ENOG4107RBI VanW family DN407_14625 ENOG4105G6Z alkaline phosphatase DN407_14635 ENOG4105VMP Transcriptional regulator DN407_14655 ENOG41068WN DN407_14685 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN407_14710 ENOG4105CKK Glycosyl transferase, family 2 DN407_14740 ENOG4105C8Y Acetylornithine aminotransferase DN407_14785 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN407_14795 ENOG4108IBT Inherit from COG: transposase DN407_14815 ENOG4108TVJ Nitroreductase DN407_14820 ENOG4105FS7 Transcriptional regulator DN407_14835 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DN407_14840 ENOG4105WEC Molybdate metabolism regulator DN407_14860 ENOG4108DMH HTH_ARAC DN407_14865 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DN407_14870 ENOG4108XET gCN5-related N-acetyltransferase DN407_14885 ENOG4108PCN EamA-like transporter family DN407_14905 ENOG4107XJU UPF0178 protein DN407_14940 ENOG410635A Membrane DN407_14950 ENOG4108IQI permease DN407_14965 ENOG4105F1N DNA alkylation repair DN407_15000 ENOG4107RF6 penicillin-binding protein DN407_15005 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DN407_15025 ENOG4105E7W lamb ycsf family protein DN407_15035 ENOG4105P4J Allophanate hydrolase, subunit 1 DN407_15040 ENOG4107258 Transcriptional regulator DN407_15050 ENOG4106N3A copper homeostasis protein cutc DN407_15055 ENOG4108ZHR arsR family transcriptional regulator DN407_15065 ENOG4105FDT acyl-CoA dehydrogenase DN407_15080 ENOG4105DWD nucleoside recognition domain protein DN407_15115 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DN407_15140 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DN407_15165 ENOG4105E2A Dehydrogenase DN407_15175 ENOG4108IJ0 Aspartate ammonia-lyase DN407_15180 ENOG4105HDK L-asparaginase DN407_15185 ENOG4108IMY Transcriptional regulator DN407_15210 ENOG4108B31 Spore germination protein DN407_15220 ENOG4105BZU Histidine kinase DN407_15245 ENOG41075H3 AraC family transcriptional regulator DN407_15265 ENOG4105YWU small acid-soluble spore protein DN407_15270 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DN407_15275 ENOG4105CUB amino acid DN407_15280 ENOG4105II7 pyrroline-5-carboxylate reductase DN407_15285 ENOG4108NHD germination protein DN407_15290 ENOG4108Q8B Spore germination protein DN407_15340 ENOG4105CGH 5'-nucleotidase DN407_15350 ENOG4105CHJ isochorismatase hydrolase DN407_15385 ENOG4105EQ0 Major Facilitator superfamily DN407_15445 ENOG4105F6J Alpha beta hydrolase fold DN407_15460 ENOG4108606 TspO/MBR family DN407_15465 ENOG4105CVP deoxyribo-dipyrimidine photolyase DN407_15480 ENOG4108TWJ NADH dehydrogenase subunit 5 DN407_15485 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DN407_15490 ENOG4107VMI polysaccharide deacetylase DN407_15495 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN407_15500 ENOG4105BZU Histidine kinase DN407_15505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_15510 ENOG4105KY5 gCN5-related N-acetyltransferase DN407_15515 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN407_15520 ENOG4105ECQ AraC Family Transcriptional Regulator DN407_15525 ENOG4105Z7P Acetyltransferase (GNAT) family DN407_15535 ENOG4105D6J arsenicaL-resistance protein DN407_15540 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DN407_15545 ENOG41085FC arsR family transcriptional regulator DN407_15570 ENOG4105NAE bifunctional deaminase-reductase domain protein DN407_15600 ENOG4107P5I polyketide synthase DN407_15605 ENOG4108IG5 Transcriptional regulator DN407_15610 ENOG4105F27 Major Facilitator DN407_15615 ENOG4105M4P Tetr family transcriptional regulator DN407_15620 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DN407_15625 ENOG4108YXU transcriptional regulator AsnC family DN407_15655 ENOG4105N0V mono-oxygenase ydhR DN407_15730 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DN407_15735 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN407_15750 ENOG4105K6H D-cysteine desulfhydrase DN407_15760 ENOG4105E0Y RtcB Protein DN407_15770 ENOG4105JQZ Methyltransferase DN407_15790 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DN407_15810 ENOG4105BZU Histidine kinase DN407_15820 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN407_15850 ENOG4108JQ1 Dehydrogenase DN407_15855 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DN407_15895 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN407_15965 ENOG4108VXD carboxy-peptidase DN407_15970 ENOG4105PNM synthesis protein DN407_15980 ENOG4108ISG Major Facilitator DN407_15995 ENOG4107MII Sugar-specific transcriptional regulator TrmB DN407_16000 ENOG4105CZM Major Facilitator DN407_16020 ENOG4105CRW Short chain fatty acid transporter DN407_16030 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN407_16090 ENOG4108K8S endonuclease I DN407_16105 ENOG41067QW Transcriptional regulator DN407_16110 ENOG4108Z66 YbaK ebsC protein DN407_16120 ENOG4105KVH Transcriptional regulator DN407_16125 ENOG4108RCM Nitroreductase DN407_16155 ENOG4108PSK reductase DN407_16225 ENOG4105C31 Tryptophanyl-tRNA synthetase DN407_16230 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DN407_16260 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) DN407_16270 ENOG4105EV4 Multidrug resistance protein mdtH DN407_16300 ENOG4105C37 (CBS) domain DN407_16315 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DN407_16320 ENOG4105FAW cDP-glucose 4,6-dehydratase DN407_16355 ENOG4105DDN Pentapeptide repeat-containing protein DN407_16360 ENOG4105XDF Protein of unknown function (DUF1272) DN407_16365 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DN407_16370 ENOG4105CMG Carbohydrate kinase DN407_16375 ENOG4105C6Z Gluconate DN407_16390 ENOG4105CV1 Transketolase (EC 2.2.1.1) DN407_16395 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DN407_16410 ENOG4105CIS alcohol dehydrogenase DN407_16415 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DN407_16425 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DN407_16440 ENOG4108UX3 '-nucleotidase DN407_16445 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DN407_16450 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DN407_16455 ENOG4105KVH Transcriptional regulator DN407_16470 ENOG4105CV8 reductase DN407_16475 ENOG4105F27 Major Facilitator DN407_16485 ENOG41090KN UPF0303 protein DN407_16495 ENOG4105FS7 Transcriptional regulator DN407_16505 ENOG4105C44 Serine transporter DN407_16545 ENOG4108TZY GntR Family Transcriptional Regulator DN407_16550 ENOG4105D9R oxidoreductase DN407_16555 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DN407_16560 ENOG4105KVH Transcriptional regulator DN407_16565 ENOG4105KVH Transcriptional regulator DN407_16610 ENOG4105JAB phenazine biosynthesis protein, phzf family DN407_16615 ENOG4105KNA -acetyltransferase DN407_16625 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DN407_16630 ENOG4105KVH Transcriptional regulator DN407_16645 ENOG4108ZJ4 polysaccharide deacetylase DN407_16725 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DN407_16750 ENOG4105H3G oxidoreductase DN407_16820 ENOG4108TN2 lmbE family DN407_16830 ENOG4107R3E Citrate transporter DN407_16840 ENOG4105WCN acetyltransferase DN407_16845 ENOG4105J76 Periplasmic binding protein DN407_16850 ENOG4105EHG Permease protein DN407_16855 ENOG4105DQ5 transport system permease protein DN407_16880 ENOG41068WN DN407_16885 ENOG4107CUJ Protein of unknown function (DUF2690) DN407_16895 ENOG4107V2S Transcriptional regulator DN407_16905 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DN407_16920 ENOG4105C98 muts2 protein DN407_16925 ENOG4105E5K Alpha-amylase DN407_16930 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DN407_16935 ENOG4105DPN Oligoendopeptidase f DN407_16940 ENOG4108A04 Beta-lactamase DN407_16965 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DN407_16975 ENOG41082BM Transcriptional regulator, arsr family DN407_16980 ENOG4105CIS alcohol dehydrogenase DN407_17005 ENOG4105CQB FAD linked oxidase domain protein DN407_17030 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN407_17040 ENOG4107TPS domain protein DN407_17045 ENOG4105CEP NADH dehydrogenase DN407_17055 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DN407_17065 ENOG4108IAJ Nad-dependent epimerase dehydratase DN407_17070 ENOG4105FAW cDP-glucose 4,6-dehydratase DN407_17125 ENOG4105BZU Histidine kinase DN407_17130 ENOG4105C5H ABC transporter DN407_17140 ENOG4107DUR UPF0457 protein DN407_17160 ENOG4105BZU Histidine kinase DN407_17170 ENOG4105KT7 mgtC SapB transporter DN407_17180 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN407_17185 ENOG41073R8 VanW family DN407_17195 ENOG4108R1P DN407_17210 ENOG4105VEQ Cold shock protein DN407_17235 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DN407_17255 ENOG410904N short-chain dehydrogenase reductase DN407_17265 ENOG4106IQC argininosuccinate lyase DN407_17280 ENOG4108IA2 Sodium pantothenate symporter DN407_17285 ENOG4105RG0 Membrane DN407_17290 ENOG4105C26 Dehydrogenase DN407_17295 ENOG4105CHR reductase DN407_17305 ENOG4105EWU Squalene--hopene cyclase DN407_17315 ENOG4105FR1 rard protein DN407_17320 ENOG410696E Membrane DN407_17335 ENOG4105D1F ATP-binding protein DN407_17345 ENOG4108ZAF Molybdopterin DN407_17350 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN407_17355 ENOG4105D06 uba thif-type nad fad binding protein DN407_17360 ENOG4105TMB Formate nitrite transporter DN407_17370 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN407_17375 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DN407_17385 ENOG4108JB9 formate dehydrogenase DN407_17390 ENOG4105E1K spore germination protein DN407_17405 ENOG4105CUB amino acid DN407_17460 ENOG4108KGH TRANSCRIPTIONal DN407_17470 ENOG4105EMN RNA polymerase sigma factor DN407_17480 ENOG4105CIG ABC transporter DN407_17500 ENOG4105D9R oxidoreductase DN407_17510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN407_17515 ENOG4105K4P CoA-binding domain protein DN407_17520 ENOG4105C0H protease DN407_17525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_17535 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DN407_17540 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DN407_17545 ENOG4105W8X HesB YadR YfhF-family protein DN407_17575 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN407_17580 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN407_17595 ENOG4105BZ1 (ABC) transporter DN407_17600 ENOG4108I0Z Aconitate hydratase DN407_17630 ENOG4105E5W Transporter DN407_17640 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN407_17660 ENOG4107F3J Amp-dependent synthetase and ligase DN407_17665 ENOG4107ZYJ bioY protein DN407_17670 ENOG4105CEY Amp-dependent synthetase and ligase DN407_17675 ENOG4108IMY Transcriptional regulator DN407_17700 ENOG4105D9G High-affinity DN407_17705 ENOG4105IW1 AmiS UreI transporter DN407_17720 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DN407_17760 ENOG4107AYK membrAne DN407_17775 ENOG4105BZU Histidine kinase DN407_17780 ENOG4105FBA Phospholipase Carboxylesterase DN407_17785 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DN407_17795 ENOG4105CBC glutamate synthase DN407_17800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DN407_17805 ENOG4108VJ1 Transcriptional regulator (CarD family DN407_17810 ENOG4108903 Formimidoylglutamase DN407_17820 ENOG4105CGP Urocanate hydratase DN407_17835 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DN407_17870 ENOG4107QIV Cytochrome c biogenesis protein DN407_17885 ENOG4105CH2 amidohydrolase DN407_17895 ENOG4105CJ1 ABC, transporter DN407_17910 ENOG4107RSM transcriptional regulator DN407_17915 ENOG4105VAW lrga family DN407_17920 ENOG41067MG lrgb family DN407_17960 ENOG4105BZ1 (ABC) transporter DN407_17965 ENOG4105BZ1 (ABC) transporter DN407_18005 ENOG4108HW3 (ABC) transporter DN407_18010 ENOG4105CGH 5'-nucleotidase DN407_18020 ENOG4108SVB resolvase DN407_18040 ENOG4105K7K Transcriptional regulator DN407_18045 ENOG4105C5F glutamine synthetase DN407_18050 ENOG4105KV4 Transcriptional regulator DN407_18055 ENOG4105CXI aluminum resistance protein DN407_18060 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN407_18065 ENOG4105EN6 Membrane DN407_18070 ENOG4106F1P AAA ATPase, central domain protein DN407_18100 ENOG41069ER domain protein DN407_18105 ENOG4105DM4 PTS System DN407_18110 ENOG4105DE4 1-phosphofructokinase DN407_18115 ENOG4105E98 transcriptional regulator DeoR family DN407_18120 ENOG4107QW4 alcohol dehydrogenase DN407_18125 ENOG4108SJC Membrane DN407_18135 ENOG4105C85 amino acid DN407_18155 ENOG4105TMB Formate nitrite transporter DN407_18160 ENOG4105K70 DNA-binding protein DN407_18170 ENOG4105C59 p-type ATPase DN407_18175 ENOG410681U heavy metal transport detoxification protein DN407_18180 ENOG4105VPX protein, conserved in bacteria DN407_18190 ENOG4105NIV Esterase DN407_18195 ENOG4105E0A ABC, transporter DN407_18225 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN407_18230 ENOG4105D03 DNA-3-methyladenine glycosylase II DN407_18255 ENOG4105BZU Histidine kinase DN407_18275 ENOG4105C5E polysaccharide biosynthesis protein DN407_18295 ENOG41067MG lrgb family DN407_18315 ENOG4108S3Y transcriptional regulator DN407_18320 ENOG4105CS2 ec 3.2.1.21 DN407_18335 ENOG4105F0V Cell wall hydrolase DN407_18350 ENOG4105E0M Sulfatase DN407_18355 ENOG410890F Dynamin family DN407_18390 ENOG4105DQU oxidoreductase, subunit beta DN407_18395 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DN407_18400 ENOG4108IGT Dipeptidase DN407_18405 ENOG4105MCT stage V sporulation protein S DN407_18410 ENOG4105D48 metallophosphoesterase DN407_18430 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DN407_18445 ENOG4105XZV Protein of unknown function (DUF3243) DN407_18450 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DN407_18470 ENOG4105UIB (ABC) transporter DN407_18475 ENOG4108JQ9 ABC transporter DN407_18480 ENOG4105DIH basic membrane DN407_18485 ENOG4105FDP GntR family transcriptional regulator DN407_18495 ENOG4105CNU cell division protein FtsK DN407_18505 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DN407_18515 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN407_18525 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN407_18530 ENOG4108S0H Dipicolinic acid synthetase, b subunit DN407_18535 ENOG4108IBT Inherit from COG: transposase DN407_18710 ENOG4105CDU Replicative dna helicase DN407_18790 ENOG4105E35 Dipicolinate synthase subunit A DN407_18800 ENOG4105C1V Peptidase, M16 DN407_18820 ENOG4105DTN riboflavin biosynthesis protein ribF DN407_18835 ENOG4105W7A Protein of unknown function (DUF503) DN407_18845 ENOG4105VHM ribosomal protein DN407_18850 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DN407_18855 ENOG4105CHV Transcription elongation factor NusA DN407_18865 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN407_18875 ENOG4105DZP Membrane-associated zinc metalloprotease DN407_18880 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DN407_18885 ENOG4105KNE Phosphatidate cytidylyltransferase DN407_18890 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DN407_18900 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DN407_18930 ENOG4108HE4 integrase family DN407_18940 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DN407_18945 ENOG4105C79 DNA protecting protein DprA DN407_18950 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DN407_18965 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DN407_18990 ENOG4105VB6 UPF0109 protein DN407_19010 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DN407_19015 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DN407_19030 ENOG4105CHR reductase DN407_19035 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DN407_19050 ENOG4105CB5 ATP-dependent DNA helicase recG DN407_19055 ENOG4105DP4 dak2 domain fusion protein ylov DN407_19060 ENOG4108ZAA Alkaline-shock protein DN407_19075 ENOG4105FJ0 thiamine DN407_19080 ENOG4105DJV ribulose-phosphate 3-epimerase DN407_19085 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DN407_19090 ENOG4105D9P serine threonine protein kinase DN407_19095 ENOG4108ZF3 Phosphatase DN407_19105 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DN407_19120 ENOG4105C25 Primosomal protein n' DN407_19125 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DN407_19145 ENOG4105DSJ YicC domain protein DN407_19155 ENOG4105F23 Fibronectin-binding protein DN407_19165 ENOG4105DC7 peptidase M24 DN407_19190 ENOG4107XGZ Hydrolase DN407_19210 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DN407_19215 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DN407_19225 ENOG4105CD3 dihydroorotase DN407_19245 ENOG4105C34 Pseudouridine synthase DN407_19260 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN407_19270 ENOG4105DBK s4 domain protein DN407_19275 ENOG41067XK integral membrane protein DN407_19285 ENOG4105DFA alanine racemase domain protein DN407_19290 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DN407_19295 ENOG4105WR5 sporulation protein, YlmC YmxH family DN407_19305 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN407_19315 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DN407_19320 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DN407_19330 ENOG4105D4A Cell wall formation (By similarity) DN407_19335 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN407_19340 ENOG4105CNI cell division protein FtsW DN407_19355 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DN407_19360 ENOG4105CJN penicillin-binding protein DN407_19365 ENOG4105CJN penicillin-binding protein DN407_19380 ENOG41074B2 UPF0747 protein DN407_19405 ENOG4105KNH Nucleic acid-binding protein DN407_19415 ENOG41063PX domain protein DN407_19420 ENOG4105D78 K07001 NTE family protein DN407_19425 ENOG4105H20 Sporulation integral membrane protein YlbJ DN407_19435 ENOG4106H78 methyltransferase DN407_19455 ENOG4107TB6 phosphoglycerate mutase DN407_19470 ENOG4106UY4 Inherit from COG: Scp-like extracellular DN407_19520 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DN407_19530 ENOG4105CNI cell division protein FtsW DN407_19545 ENOG4108IAB Phoh family DN407_19565 ENOG4105QA2 DN407_19570 ENOG4105CI3 gtp-binding protein typa DN407_19580 ENOG4105ECY inositol monophosphatase DN407_19600 ENOG4105CXN decarboxylase DN407_19650 ENOG4105CPP Dehydrogenase, E1 component DN407_19665 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DN407_19670 ENOG4108X4Q Hydrolase DN407_19685 ENOG4105CN5 Metallo-Beta-Lactamase DN407_19690 ENOG4107ZYR domain protein DN407_19725 ENOG4108XRC Protein of unknown function (DUF458) DN407_19730 ENOG4107IN1 Protein of unknown function (DUF1797) DN407_19745 ENOG4105EPM Diguanylate phosphodiesterase DN407_19750 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DN407_19765 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DN407_19775 ENOG4105UIN DN407_19815 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DN407_19835 ENOG4108HGU Histidine kinase DN407_19845 ENOG4105CHM Aminotransferase DN407_19850 ENOG4105FKQ transcriptional regulator DN407_19855 ENOG4105EG2 ABC transporter, permease DN407_19865 ENOG4107FKK extracellular solute-binding protein family 1 DN407_19875 ENOG4105CG3 alpha amylase, catalytic region DN407_19920 ENOG4105CHU acetyl-coa acetyltransferase DN407_19960 ENOG4105DTD Dehydrogenase DN407_19980 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DN407_20005 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DN407_20020 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN407_20030 ENOG4105BZU Histidine kinase DN407_20050 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DN407_20065 ENOG4105CID antiterminator DN407_20075 ENOG4105FDP GntR family transcriptional regulator DN407_20085 ENOG4105CE4 GlcNAc 6-P deacetylase DN407_20125 ENOG4107ZE5 PPIases accelerate the folding of proteins DN407_20130 ENOG4105PTM secreted protein DN407_20135 ENOG4105J7I hydrolase DN407_20145 ENOG4105G6R Stage v sporulation protein ae DN407_20155 ENOG4105CZ3 stage V sporulation protein ad DN407_20160 ENOG41090VF Stage v sporulation protein ac DN407_20180 ENOG4105C8J )-transporter DN407_20185 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN407_20195 ENOG41082AN stage II sporulation protein DN407_20200 ENOG4105DZ1 carboxypeptidase DN407_20210 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN407_20215 ENOG4105DVE abc transporter atp-binding protein DN407_20245 ENOG4105D7N magnesium and cobalt transport protein CorA DN407_20270 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DN407_20280 ENOG4105I3K Ferric uptake regulator, Fur family DN407_20285 ENOG4105MZ9 stage II sporulation protein m DN407_20305 ENOG4105CPC Aldo Keto reductase DN407_20315 ENOG4105RHY Pfam:UPF0157 DN407_20335 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DN407_20345 ENOG4105ETE Transcriptional regulator (LacI family DN407_20350 ENOG4108YM7 Gcn5-related n-acetyltransferase DN407_20375 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DN407_20380 ENOG4108R6K riboflavin synthase, subunit alpha DN407_20405 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN407_20410 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN407_20425 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN407_20435 ENOG4105DFD Na H antiporter DN407_20440 ENOG4105CGH 5'-nucleotidase DN407_20465 ENOG4105DBV ornithine carbamoyltransferase DN407_20480 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DN407_20495 ENOG4108IXY short-chain dehydrogenase reductase DN407_20500 ENOG41069FQ Metallo-beta-lactamase superfamily DN407_20505 ENOG4105II7 pyrroline-5-carboxylate reductase DN407_20510 ENOG4105EJQ L-serine dehydratase DN407_20525 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DN407_20540 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DN407_20555 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DN407_20560 ENOG4105D9U N-acetyltransferase DN407_20570 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DN407_20575 ENOG4108QEG Membrane DN407_20580 ENOG4105CDA abc transporter atp-binding protein DN407_20585 ENOG4105E5Q amino acid AbC transporter DN407_20590 ENOG4108HW3 (ABC) transporter DN407_20610 ENOG4108QY0 Membrane DN407_20620 ENOG4105C7S Dehydrogenase DN407_20625 ENOG4105CPP Dehydrogenase, E1 component DN407_20645 ENOG4107RDP Dehydrogenase DN407_20660 ENOG4108JUB Transcriptional regulator DN407_20670 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN407_20685 ENOG4107QQR Sporulation DN407_20695 ENOG4105S1Z Stage IV sporulation protein B DN407_20700 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DN407_20705 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DN407_20710 ENOG4105DX0 Hemolysin A DN407_20720 ENOG4105CTB Polyprenyl synthetase DN407_20735 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DN407_20745 ENOG4108ZSR alkaline shock protein DN407_20750 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN407_20775 ENOG410644B Stage III sporulation protein af DN407_20785 ENOG4105KQ4 Stage iii sporulation protein ad DN407_20790 ENOG4108CQH stage III sporulation protein AC DN407_20795 ENOG4105KR5 Stage iii sporulation protein DN407_20800 ENOG4105CD2 stage iii sporulation protein aa DN407_20825 ENOG4105DC7 peptidase M24 DN407_20830 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DN407_20840 ENOG4105CBJ Metal-dependent enzyme DN407_20850 ENOG4107YBY Hydrolase DN407_20880 ENOG41082GG biotin lipoate A B protein ligase DN407_20885 ENOG4105WZW rhodanese family DN407_20910 ENOG41080TC multidrug resistance protein DN407_20940 ENOG4105CJ1 ABC, transporter DN407_20945 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN407_20960 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DN407_20980 ENOG4105C0D helicase DN407_21100 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN407_21105 ENOG4105C3R Methionine synthase DN407_21115 ENOG4105C28 cystathionine DN407_21120 ENOG4105C28 cystathionine DN407_21140 ENOG4105C5X domain protein DN407_21150 ENOG4105DKQ ROK family DN407_21160 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DN407_21175 ENOG4108UTW Plays a role in the regulation of phosphate uptake DN407_21180 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DN407_21185 ENOG4105C8U phosphate abc transporter DN407_21190 ENOG4105C8U phosphate abc transporter DN407_21200 ENOG4107RF6 penicillin-binding protein DN407_21210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN407_21235 ENOG4105N80 Ferric uptake regulator, Fur family DN407_21245 ENOG4105FDK ABC transporter DN407_21250 ENOG4108JYZ YitT family DN407_21255 ENOG41069ZM Protein of unknown function (DUF2624) DN407_21280 ENOG4105EGD dinuclear metal center protein, YbgI family DN407_21295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN407_21300 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DN407_21325 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DN407_21330 ENOG4105KG3 cytidine deaminase DN407_21335 ENOG4107YR5 Diacylglycerol kinase DN407_21345 ENOG4105CTJ Metal Dependent Phosphohydrolase DN407_21350 ENOG4105C9A Phoh family DN407_21360 ENOG41068P3 sporulation protein YqfC DN407_21370 ENOG4105KTH gatB Yqey DN407_21385 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DN407_21390 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DN407_21420 ENOG4105CSA Coproporphyrinogen iii oxidase DN407_21425 ENOG4105KVH Transcriptional regulator DN407_21450 ENOG4105TQK DNA polymerase iii, delta' subunit DN407_21460 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DN407_21465 ENOG4108UK2 deaminase DN407_21470 ENOG4105KQC Competence protein DN407_21480 ENOG4105DXX methyltransferase DN407_21490 ENOG4108WF2 Metal Dependent Phosphohydrolase DN407_21500 ENOG410812S Rna-binding protein DN407_21510 ENOG4105CQW ribosome biogenesis GTPase YqeH DN407_21515 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DN407_21530 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN407_21550 ENOG4108TVJ Nitroreductase DN407_21565 ENOG4105G6Z alkaline phosphatase DN407_21570 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DN407_21575 ENOG4108MUZ hydrolase DN407_21615 ENOG4105MIR Phenylalanine 4-monooxygenase DN407_21625 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN407_21665 ENOG4105S6R Iron-hydroxamate transporter permease subunit DN407_21670 ENOG4108V5C ABC transporter DN407_21685 ENOG4108EKI Dehydrogenase DN407_21690 ENOG4105C28 cystathionine DN407_21720 ENOG4107XRG penicillin-binding protein DN407_21730 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DN407_21740 ENOG4105CFP Peptidase U32 DN407_21745 ENOG4105XYU peptidase (U32 family) DN407_21750 ENOG4108VQJ O-methyltransferase DN407_21755 ENOG4105HHA aminodeoxychorismate lyase DN407_21775 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN407_21785 ENOG4105C02 permease DN407_21800 ENOG41060CR DN407_21805 ENOG4105C7H Helicase, RecD TraA family DN407_21815 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DN407_21820 ENOG4105C3J Cysteine desulfurase DN407_21830 ENOG4105D1H recombination factor protein RarA DN407_21835 ENOG4108VCI transcription factor, rsfa family DN407_21845 ENOG4105CUZ uba thif-type nad fad binding protein DN407_21860 ENOG4105CUT histidyl-tRNA synthetase DN407_21870 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DN407_21880 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DN407_21885 ENOG41076HS cation diffusion facilitator family transporter DN407_21890 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DN407_21900 ENOG4105CKP Polysaccharide Biosynthesis Protein DN407_21905 ENOG4108QG2 Membrane DN407_21915 ENOG4105VIE preprotein translocase, subunit YajC DN407_21930 ENOG41061AI Protein of unknown function (DUF2905) DN407_21945 ENOG4108HUF Transporter DN407_21970 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DN407_21975 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DN407_21980 ENOG4108IYU L-aspartate oxidase DN407_21995 ENOG4108RPX mosc domain containing protein DN407_22010 ENOG4105CQC Prephenate dehydratase DN407_22025 ENOG4105C19 ABC transporter DN407_22030 ENOG4105EWM Histidine kinase DN407_22040 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DN407_22060 ENOG4105C03 ribonuclease DN407_22075 ENOG4107QMS site-determining protein DN407_22090 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DN407_22095 ENOG4105DFF Rod shape-determining protein mreb DN407_22115 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DN407_22120 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DN407_22135 ENOG41068KH stage VI sporulation protein D DN407_22145 ENOG4105D52 delta-aminolevulinic acid dehydratase DN407_22170 ENOG4105K56 Transcriptional regulator DN407_22190 ENOG4108IUQ atp-dependent protease DN407_22215 ENOG4108QCI YvbH-like oligomerisation region DN407_22235 ENOG4105M59 Phosphodiesterase, mj0936 family DN407_22240 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DN407_22250 ENOG4108XJQ germination protein DN407_22265 ENOG4105PFC Transcriptional regulator DN407_22275 ENOG4105DZC cytosine deaminase DN407_22280 ENOG41067S9 phage shock protein C, PspC DN407_22285 ENOG4108JCI Transcriptional regulator DN407_22295 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DN407_22300 ENOG4108Z40 Transcriptional regulator DN407_22305 ENOG4105RHA ABC transporter, permease DN407_22310 ENOG4108IUX (ABC) transporter DN407_22315 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DN407_22320 ENOG4105ER2 Ompa motb domain protein DN407_22325 ENOG4105E14 MotA TolQ exbB proton channel DN407_22330 ENOG4108VXD carboxy-peptidase DN407_22340 ENOG4105E33 succinate dehydrogenase DN407_22350 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DN407_22360 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DN407_22365 ENOG4105K63 Thioredoxin DN407_22370 ENOG4105C10 Electron transfer flavoprotein DN407_22375 ENOG4105BZJ Electron transfer flavoprotein DN407_22380 ENOG41060WC Enoyl-CoA hydratase DN407_22385 ENOG4107Z3H Transcriptional regulator, TetR family DN407_22390 ENOG4105CEY Amp-dependent synthetase and ligase DN407_22450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN407_22460 ENOG4105DR4 Methyltransferase DN407_22470 ENOG4105KFN sortase, SrtB family DN407_22475 ENOG4105E0A ABC, transporter DN407_22490 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DN407_22500 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DN407_22510 ENOG4105FE9 pseudouridine synthase DN407_22520 ENOG4105DCG PHP domain protein DN407_22535 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DN407_22555 ENOG4105C5S asparaginyl-tRNA synthetase DN407_22560 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DN407_22570 ENOG4108RWN rrna methyltransferase DN407_22600 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN407_22605 ENOG4105CW7 secretion protein, HlyD family DN407_22610 ENOG4108JGH Tetr family transcriptional regulator DN407_22615 ENOG4105CN9 Peptidase m42 family protein DN407_22635 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DN407_22640 ENOG4105C22 threonyL-tRNA synthetase DN407_22645 ENOG4108TDW sporulation protein YtxC DN407_22670 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DN407_22675 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DN407_22680 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DN407_22690 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DN407_22695 ENOG4105C2M dna polymerase I DN407_22700 ENOG4105BZU Histidine kinase DN407_22705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN407_22725 ENOG4108HMX isocitrate dehydrogenase (NADP) DN407_22730 ENOG4105BZN citrate synthase DN407_22745 ENOG4108REF Sporulation integral membrane protein ytvi DN407_22750 ENOG4105FS0 cytoplasmic membrane protein DN407_22775 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN407_22780 ENOG4105C6K Malic enzyme DN407_22785 ENOG4105C0B DNA polymerase III (alpha subunit) DN407_22790 ENOG4105VV2 DN407_22800 ENOG4105SFS phosphoesterase RecJ domain protein DN407_22820 ENOG4105E8R UPF0173 metal-dependent hydrolase DN407_22825 ENOG4105DC7 peptidase M24 DN407_22870 ENOG41082W1 Cupin 2, conserved barrel domain protein DN407_22890 ENOG4107YZX Universal stress protein DN407_22925 ENOG4108JYZ YitT family DN407_22945 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DN407_22955 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DN407_22960 ENOG4105KBJ sporulation protein ytfj DN407_22975 ENOG4105EFZ amidohydrolase DN407_22985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN407_23010 ENOG4105RQF LysR family Transcriptional regulator DN407_23020 ENOG4105U5Y Transcriptional regulator DN407_23030 ENOG4105C28 cystathionine DN407_23040 ENOG4108IBT Inherit from COG: transposase DN407_23085 ENOG4105EMN RNA polymerase sigma factor DN407_23095 ENOG4108UW5 maltose o-acetyltransferase DN407_23105 ENOG4105F1V Acetoin utilization protein DN407_23110 ENOG4105W87 Cbs domain DN407_23115 ENOG4105DGU Histone deacetylase DN407_23130 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN407_23135 ENOG4105BZU Histidine kinase DN407_23140 ENOG4107SNB ankyrin repeat protein YahD DN407_23165 ENOG4105DY9 regulatoR DN407_23170 ENOG4105EP9 oxidoreductase DN407_23190 ENOG4105ETE Transcriptional regulator (LacI family DN407_23195 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN407_23215 ENOG4105C88 aminopeptidase DN407_23250 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN407_23260 ENOG4108VDD TRNA binding domain protein DN407_23290 ENOG4105C8F Beta-lactamase domain protein DN407_23305 ENOG4108V15 phosphotransferase enzyme family DN407_23310 ENOG4108IUM Glycogen debranching enzyme DN407_23320 ENOG4107QSE Dipeptidase DN407_23325 ENOG4105YW5 deoR family transcriptional regulator DN407_23340 ENOG4105CBX hi0933 family DN407_23375 ENOG4108VJ1 Transcriptional regulator (CarD family DN407_23380 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DN407_23385 ENOG4105CSC Glucose uptake protein DN407_23400 ENOG4108ZAF Molybdopterin DN407_23405 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DN407_23410 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN407_23420 ENOG4105D06 uba thif-type nad fad binding protein DN407_23425 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN407_23450 ENOG41085GJ domain protein DN407_23460 ENOG4105DWV Homoserine O-trans-acetylase DN407_23470 ENOG4108B31 Spore germination protein DN407_23500 ENOG4105C8T Leucyl-tRNA synthetase DN407_23505 ENOG410605W Major Facilitator DN407_23510 ENOG4107S91 Sodium hydrogen exchanger DN407_23515 ENOG4105NCW Trka-c domain protein DN407_23535 ENOG4105C19 ABC transporter DN407_23555 ENOG4105N5T Radical SAM Protein DN407_23570 ENOG4105DA5 (ABC) transporter DN407_23600 ENOG4105E8V Alpha Beta Hydrolase Fold protein DN407_23605 ENOG4108Z0R Transferase DN407_23610 ENOG4105YVM Phosphoesterase, PA-phosphatase related DN407_23615 ENOG4105BZF Glycosyl transferase (Group 1 DN407_23625 ENOG4105EPU Molybdenum cofactor synthesis domain protein DN407_23640 ENOG4108MK9 spermidine N(1)-acetyltransferase DN407_23680 ENOG4105BZU Histidine kinase DN407_23685 ENOG4105BZU Histidine kinase DN407_23690 ENOG4107S9D Alpha beta hydrolase DN407_23695 ENOG4107T7U Sulfatase DN407_23720 ENOG4105D2X ABC transporter substrate-binding protein DN407_23730 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DN407_23800 ENOG4108V2W Carbonate dehydratase DN407_23805 ENOG4105C4M (Ubiquinol oxidase) subunit I DN407_23810 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN407_23845 ENOG41087YS Phage shock protein A DN407_23875 ENOG4105BZU Histidine kinase DN407_23880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_23905 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN407_23910 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DN407_23940 ENOG4107ZTW SNARE associated Golgi DN407_23955 ENOG4105C19 ABC transporter DN407_23960 ENOG41086D8 Transcriptional regulator DN407_23985 ENOG41082BM Transcriptional regulator, arsr family DN407_24035 ENOG4105C6Z Gluconate DN407_24040 ENOG4105FDP GntR family transcriptional regulator DN407_24060 ENOG41069H0 dihydroorotase EC 3.5.2.3 DN407_24080 ENOG4105DTQ mandelate racemase muconate lactonizing DN407_24090 ENOG4108IPT Naphthoate synthase DN407_24095 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DN407_24105 ENOG4105E4F Isochorismate synthase DN407_24110 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN407_24120 ENOG4105VEQ Cold shock protein DN407_24150 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DN407_24175 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN407_24270 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DN407_24305 ENOG4105KT7 mgtC SapB transporter DN407_24310 ENOG4107PBV potassium channel DN407_24330 ENOG4105WG9 Conserved Protein DN407_24340 ENOG4105CHM Aminotransferase DN407_24345 ENOG4108ZB6 transcriptional regulator AsnC family DN407_24350 ENOG4105C5I Dehydrogenase DN407_24355 ENOG4108MUZ hydrolase DN407_24365 ENOG4105C87 Aminotransferase class I and II DN407_24375 ENOG4105Y38 Kinase-associated protein B DN407_24385 ENOG4107R3E Citrate transporter DN407_24400 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DN407_24405 ENOG4105KA0 thioesterase Superfamily protein DN407_24420 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN407_24440 ENOG41069ER domain protein DN407_24455 ENOG4105CEP NADH dehydrogenase DN407_24485 ENOG4105EWC Purine nucleoside phosphorylase DN407_24500 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DN407_24525 ENOG4108JJA ABC, transporter DN407_24530 ENOG4105C4B ABC transporter, permease DN407_24535 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DN407_24565 ENOG41083MR nifu domain-containing protein DN407_24580 ENOG4108W5N phosphatidylglycerophosphatase a DN407_24600 ENOG4105DAX Pfam:DUF2983 DN407_24615 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN407_24620 ENOG4105D4U had-superfamily hydrolase, subfamily iia DN407_24635 ENOG4105CBT Fructose-1,6-bisphosphatase DN407_24650 ENOG4105MMD transcriptional regulator DN407_24655 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DN407_24660 ENOG4107TXC Transcriptional regulator DN407_24665 ENOG41090T1 Membrane DN407_24690 ENOG4105FAA peptidase M23 DN407_24695 ENOG4108YTE sporulation protein YunB DN407_24700 ENOG4105KZD Domain of unknown function (DUF1805) DN407_24705 ENOG4107R8B 5'-nucleotidase DN407_24715 ENOG4105DIW FeS assembly protein SUFB DN407_24720 ENOG4108UNV SUF system FeS assembly protein, NifU family DN407_24725 ENOG4105C9B Cysteine desulfurase DN407_24730 ENOG4105JRK feS assembly protein SufD DN407_24735 ENOG4105C3K feS assembly ATPase SufC DN407_24740 ENOG4105D01 (LipO)protein DN407_24745 ENOG4105D01 (LipO)protein DN407_24750 ENOG4108UMI ABC transporter, permease DN407_24755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DN407_24780 ENOG41080E8 Transcriptional regulator, Spx MgsR family DN407_24800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN407_24825 ENOG4108W8B Beta-lactamase domain protein DN407_24830 ENOG4105C1G acyl-Coa dehydrogenase DN407_24835 ENOG4105CHU acetyl-coa acetyltransferase DN407_24850 ENOG4105DZ1 carboxypeptidase DN407_24870 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN407_24885 ENOG4108SUT Major Facilitator Superfamily DN407_24890 ENOG4107R7I amino acid DN407_24900 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN407_24910 ENOG4107AYK membrAne DN407_24950 ENOG4107ZTW SNARE associated Golgi DN407_24960 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN407_24965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_24970 ENOG4105BZU Histidine kinase DN407_24985 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN407_25000 ENOG4105C8Q Methyl-accepting chemotaxis DN407_25005 ENOG4105VG1 fes assembly suf system protein DN407_25010 ENOG4105D4Y metalloprotease DN407_25030 ENOG4107T5V SNARE associated Golgi DN407_25035 ENOG4107S91 Sodium hydrogen exchanger DN407_25040 ENOG4105NCW Trka-c domain protein DN407_25050 ENOG4108RMU ferritin dps family protein DN407_25065 ENOG4108URH decarboxylase DN407_25075 ENOG41090A1 ferritin DN407_25080 ENOG4105DHF Membrane DN407_25085 ENOG4105D9N nucleoside DN407_25090 ENOG4105D9N nucleoside DN407_25105 ENOG4108RYK Nad-dependent epimerase dehydratase DN407_25120 ENOG4105CV8 reductase DN407_25125 ENOG4105F27 Major Facilitator DN407_25130 ENOG4105KVH Transcriptional regulator DN407_25145 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DN407_25150 ENOG4105D4A Cell wall formation (By similarity) DN407_25160 ENOG4105C8Q Methyl-accepting chemotaxis DN407_25170 ENOG4105WMR Protein CrcB homolog DN407_25175 ENOG4105WMR Protein CrcB homolog DN407_25195 ENOG4105C5H ABC transporter DN407_25200 ENOG4108MK9 spermidine N(1)-acetyltransferase DN407_25205 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DN407_25225 ENOG4108IPW abc transporter atp-binding protein DN407_25230 ENOG4105CM4 permease protein DN407_25245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_25265 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DN407_25275 ENOG4105XZU Preprotein translocase, subunit SecG DN407_25280 ENOG41067MG lrgb family DN407_25330 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN407_25395 ENOG41090VF Stage v sporulation protein ac DN407_25400 ENOG4105CZ3 stage V sporulation protein ad DN407_25415 ENOG4108QY0 Membrane DN407_25420 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN407_25430 ENOG4105KRI phosphocarrier protein (HPr DN407_25440 ENOG4105CHW UPF0052 protein DN407_25445 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DN407_25450 ENOG4108Z4K mutator MutT protein DN407_25460 ENOG4105C3M thioredoxin reductase DN407_25470 ENOG4108S4C acetyltransferase DN407_25490 ENOG41086DT Membrane protein of unknown function DN407_25500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DN407_25505 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DN407_25520 ENOG4107TXC Transcriptional regulator DN407_25540 ENOG4105DUM transcriptional regulator, lysR family DN407_25550 ENOG4108WS4 fmn reductase DN407_25565 ENOG4105BZ1 (ABC) transporter DN407_25575 ENOG4105CN1 protease DN407_25580 ENOG4105CRP Part of the ABC transporter FtsEX involved in DN407_25585 ENOG4105CAK Cell division ATP-binding protein ftsE DN407_25615 ENOG4108RDQ ABC transporter DN407_25645 ENOG4105MS2 ribosomal subunit Interface protein DN407_25650 ENOG4105VEQ Cold shock protein DN407_25655 ENOG41081UC Inherit from COG: Competence protein DN407_25670 ENOG4105KVH Transcriptional regulator DN407_25680 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DN407_25685 ENOG4108KGH TRANSCRIPTIONal DN407_25690 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DN407_25695 ENOG4105C6Y Udp-glucose 6-dehydrogenase DN407_25700 ENOG4105ESV Glycosyl transferase, family 4 DN407_25710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DN407_25730 ENOG4105F8D glycoside hydrolase family 4 DN407_25735 ENOG4105VCP PTS System DN407_25740 ENOG4105CK1 PTS System DN407_25750 ENOG4105VCP PTS System DN407_25760 ENOG4105VZJ PTS System DN407_25780 ENOG4105ECB domain protein DN407_25785 ENOG4107RSM transcriptional regulator DN407_25815 ENOG4105DAA L-lactate DN407_25825 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DN407_25840 ENOG4105E0M Sulfatase DN407_25870 ENOG4107R8N Glycosyl transferase, family 2 DN407_25875 ENOG4105C94 Transporter DN407_25885 ENOG41069ER domain protein DN407_25910 ENOG4105KBK Zinc finger, swim domain protein DN407_25915 ENOG4105C0D helicase DN407_25945 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN407_25955 ENOG4107RBB ABC transporter, permease DN407_25960 ENOG4105C19 ABC transporter DN407_25970 ENOG4105CXY transporter DN407_25985 ENOG4105BZU Histidine kinase DN407_25990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_25995 ENOG4105CMR udp-glucose 4-epimerase DN407_26000 ENOG4105CMR udp-glucose 4-epimerase DN407_26010 ENOG4108KGH TRANSCRIPTIONal DN407_26020 ENOG4105CG5 Glycosyl transferase (Group 1 DN407_26045 ENOG4107RA4 Glycosyl transferase (Group 1 DN407_26055 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN407_26060 ENOG4105C6Y Udp-glucose 6-dehydrogenase DN407_26065 ENOG4105D3Q Sugar transferase DN407_26070 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN407_26075 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DN407_26080 ENOG4107YJ4 chain length determinant protein DN407_26085 ENOG4105HTX biosynthesis protein DN407_26090 ENOG4107YJ4 chain length determinant protein DN407_26105 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DN407_26115 ENOG4105FRN stage II sporulation protein DN407_26130 ENOG4105DY9 regulatoR DN407_26150 ENOG4106778 Protein of unknown function (DUF1146) DN407_26155 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN407_26160 ENOG4105C8S subunit m DN407_26165 ENOG4105D65 subunit l DN407_26190 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN407_26195 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN407_26205 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN407_26210 ENOG4105BZU Histidine kinase DN407_26260 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DN407_26265 ENOG41062M3 atp synthase DN407_26285 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DN407_26290 ENOG4108UIC UPF0340 protein DN407_26295 ENOG4108YZG isomerase DN407_26310 ENOG4108VGI doxx family DN407_26315 ENOG4107XC4 flavin reductase domain protein, FMN-binding DN407_26330 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DN407_26340 ENOG4108ZXQ stage ii sporulation protein r DN407_26345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DN407_26350 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DN407_26355 ENOG4107104 thymidine kinase DN407_26365 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DN407_26370 ENOG4105CBT Fructose-1,6-bisphosphatase DN407_26375 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DN407_26395 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DN407_26410 ENOG4105C1G acyl-Coa dehydrogenase DN407_26415 ENOG4105C1G acyl-Coa dehydrogenase DN407_26420 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DN407_26430 ENOG4105DF6 Fe-S oxidoreductase DN407_26445 ENOG4105BZU Histidine kinase DN407_26460 ENOG4105D4Y metalloprotease DN407_26470 ENOG4105BZU Histidine kinase DN407_26475 ENOG4105KCT ABC transporter DN407_26480 ENOG4108M15 ABC transporter DN407_26485 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DN407_26495 ENOG4105IIU Aminopeptidase DN407_26515 ENOG4105EMN RNA polymerase sigma factor DN407_26525 ENOG410684U Domain of unknown function (DUF1934) DN407_26545 ENOG4105CYW agmatinase DN407_26555 ENOG4105DXB Major Facilitator superfamily DN407_26560 ENOG4107SWG transcriptional regulator MERR family DN407_26565 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN407_26570 ENOG4105BZ4 penicillin-binding protein DN407_26575 ENOG4108XFG YwhD family DN407_26580 ENOG4108Z4T Peptidase M50 DN407_26585 ENOG41069HH 4-oxalocrotonate tautomerase DN407_26590 ENOG4105DCI Phosphohydrolase DN407_26595 ENOG4108MES Periplasmic binding protein DN407_26600 ENOG4105E0A ABC, transporter DN407_26605 ENOG4105EHG Permease protein DN407_26610 ENOG4105DQ5 transport system permease protein DN407_26620 ENOG4108VCI transcription factor, rsfa family DN407_26625 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DN407_26630 ENOG4108IJ2 phosphate acetyltransferase DN407_26635 ENOG4107UEZ chlorite dismutase DN407_26645 ENOG4108VKI Cell wall hydrolase DN407_26665 ENOG4107SVH Potassium channel protein DN407_26675 ENOG410667J hydrolase DN407_26680 ENOG4105VCH membrane DN407_26690 ENOG4108TU7 Inherit from COG: (ABC) transporter DN407_26695 ENOG4105CJ1 ABC, transporter DN407_26700 ENOG41090WU lipolytic protein G-D-S-L family DN407_26715 ENOG4105D6E homoserine dehydrogenase DN407_26740 ENOG4108Y4K DNA-binding transcriptional activator DN407_26750 ENOG4105WH1 Two component transcriptional regulator luxr family DN407_26755 ENOG4105BZU Histidine kinase DN407_26760 ENOG4105DWF phosphomethylpyrimidine kinase DN407_26765 ENOG4105BZU Histidine kinase DN407_26770 ENOG4105VCD cytoplasmic protein DN407_26775 ENOG4105D22 carbon starvation protein DN407_26780 ENOG4105DY9 regulatoR DN407_26785 ENOG41079KZ Major Facilitator Superfamily DN407_26800 ENOG4105CG5 Glycosyl transferase (Group 1 DN407_26810 ENOG4105EN6 Membrane DN407_26815 ENOG4106YBV Methyl-accepting chemotaxis DN407_26825 ENOG4108S4H thioesterase Superfamily protein DN407_26830 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) DN407_26845 ENOG4105K64 Glycosyl transferase, family 2 DN407_26855 ENOG4105EJV Membrane DN407_26860 ENOG4105CKK Glycosyl transferase, family 2 DN407_26865 ENOG4105C5H ABC transporter DN407_26870 ENOG41067SE Tetr family transcriptional regulator DN407_26880 ENOG4105E0X reductase DN407_26885 ENOG4106F5Q Membrane DN407_26900 ENOG4108NEV two component transcriptional regulator, LytTR family DN407_26905 ENOG4108HRK Histidine kinase DN407_26910 ENOG4107RGD Major Facilitator superfamily DN407_26930 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN407_26940 ENOG4105IW1 AmiS UreI transporter DN407_26950 ENOG4105CMR udp-glucose 4-epimerase DN407_26955 ENOG4108UT2 hemolysin iii DN407_26965 ENOG4105C1J atp-dependent rna helicase DN407_26970 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DN407_26990 ENOG4105BZU Histidine kinase DN407_27005 ENOG4105C0H protease DN407_27010 ENOG4105Q2H domain protein DN407_27025 ENOG4105BZU Histidine kinase DN407_27030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_27055 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DN407_27060 ENOG4105CDU Replicative dna helicase DN407_27070 ENOG4105BZR domain protein DN407_27075 ENOG4108XMW Membrane DN407_27085 ENOG4108UUM single-stranded DNA-binding protein DN407_27095 ENOG4105C3G gtp-binding protein DN407_27100 ENOG4105VDK protein, conserved in bacteria DN407_27105 ENOG4105D8X mechanosensitive ion channel DN407_27110 ENOG4108ZDA Sporulation protein YyaC DN407_27115 ENOG4105FA0 parb-like partition protein DN407_27120 ENOG4107QJE Chromosome Partitioning Protein DN407_27135 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DN407_27140 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DN407_27150 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN407_27225 ENOG4107VMI polysaccharide deacetylase DN407_27240 ENOG4105BZU Histidine kinase DN407_27245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_27255 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DN407_27330 ENOG4105CNU cell division protein FtsK DN407_27635 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN407_27640 ENOG4105CZV ABC transporter DN407_27655 ENOG4105DRR Transcriptional regulator, GntR family DN407_27700 ENOG4108VJ1 Transcriptional regulator (CarD family DN407_27725 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DN407_27740 ENOG4105CVJ phosphoglycerate mutase DN407_27750 ENOG4105FS7 Transcriptional regulator DN407_27755 ENOG4105D3W isochorismatase DN407_27760 ENOG41080V3 Major Facilitator superfamily DN407_27770 ENOG4108Z6Z Transcriptional regulator DN407_27780 ENOG4105DHF Membrane DN407_27830 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) DN407_27850 ENOG4108MK9 spermidine N(1)-acetyltransferase DN407_27885 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN407_27925 ENOG4108UZ3 Transporter DN407_27935 ENOG4105DRR Transcriptional regulator, GntR family DN407_27940 ENOG4108UZ3 Transporter DN407_27955 ENOG4105CUJ penicillin amidase DN407_27995 ENOG4105CIF Ornithine Cyclodeaminase DN407_28015 ENOG4105DUX Transporter DN407_28025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN407_28030 ENOG4108594 Permease of the drug metabolite transporter DN407_28090 ENOG4105KRN Transcriptional regulator, abrb family DN407_28100 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DN407_28115 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN407_28135 ENOG4105EQ0 Major Facilitator superfamily DN407_28140 ENOG4108JGH Tetr family transcriptional regulator DN407_28155 ENOG4105D7V transposase DN407_28180 ENOG41075H3 AraC family transcriptional regulator DN407_28195 ENOG4108DMH HTH_ARAC DN407_28240 ENOG41080HT Transcriptional regulator, arsr family DN407_28300 ENOG4107QJQ Mate efflux family protein DN407_28315 ENOG4107RA9 decarboxylase DN407_28350 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DN407_28375 ENOG4107QTZ amino acid DN407_28390 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DN407_28435 ENOG410780I phosphoprotein phosphatase activity DN407_28460 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN407_28465 ENOG4105CJ1 ABC, transporter DN407_28485 ENOG4105D7V transposase DN407_28505 ENOG4105NA0 Transcriptional regulator DN407_28515 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN407_28540 ENOG4105C19 ABC transporter DN407_28575 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) DN407_28590 ENOG4105F6J Alpha beta hydrolase fold DN407_28650 ENOG4107Y80 Major Facilitator superfamily DN407_28675 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DN407_28685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_28690 ENOG4105BZU Histidine kinase DN407_28720 ENOG4105C3I Nad-dependent epimerase dehydratase DN407_28725 ENOG4107QQG Dehydrogenase DN407_28865 ENOG4108IAJ Nad-dependent epimerase dehydratase DN407_28870 ENOG4107SBE Glycosyl transferase (Group 1 DN407_28895 ENOG4107SBE Glycosyl transferase (Group 1 DN407_28900 ENOG4108KS4 Spore coat protein DN407_29095 ENOG4107Y80 Major Facilitator superfamily DN407_29105 ENOG4105C1G acyl-Coa dehydrogenase DN407_29115 ENOG4105CAQ asparagine synthetase DN407_29195 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DN407_29250 ENOG4105K56 Transcriptional regulator DN407_29275 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DN407_29350 ENOG4105C19 ABC transporter DN407_29445 ENOG4108UT6 Transferase hexapeptide repeat containing protein DN407_29455 ENOG4105K64 Glycosyl transferase, family 2 DN407_29460 ENOG4105E39 Enoyl-CoA hydratase DN407_29475 ENOG4108IMY Transcriptional regulator DN407_29500 ENOG4108IBT Inherit from COG: transposase DN407_29540 ENOG4105D9P serine threonine protein kinase DN407_29590 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) DN407_29680 ENOG4105CPQ Dehydrogenase DN407_29690 ENOG4108JPW Aminotransferase DN407_29705 ENOG4105CUB amino acid DN407_29715 ENOG4105E1K spore germination protein DN407_29740 ENOG4105K70 DNA-binding protein DN407_29745 ENOG4105D9U N-acetyltransferase DN407_29750 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein DN407_29815 ENOG4105CAQ asparagine synthetase DN407_29820 ENOG4108RZE Tetr family transcriptional regulator DN407_29860 ENOG4107VMI polysaccharide deacetylase DN407_29975 ENOG4105D7V transposase DN407_30005 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN407_30020 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DN407_30025 ENOG4105DR5 peptidase DN407_30085 ENOG4107R0E Glycosyl transferase, family 2 DN407_30120 ENOG4108WZA zeta toxin DN407_30230 ENOG4108A04 Beta-lactamase DN407_30240 ENOG4105DQ6 Transposase DN407_30250 ENOG4105D7V transposase DN407_30430 ENOG4105C19 ABC transporter DN407_30445 ENOG4105BZC d-serine deaminase DN407_30460 ENOG4105CZV ABC transporter DN407_30505 ENOG4105E5D amino acid DN407_30515 ENOG4105DWF phosphomethylpyrimidine kinase DN407_30520 ENOG4105DFD Na H antiporter DN407_30525 ENOG4105KGF protein, YerC YecD DN407_30545 ENOG4105EKQ RNA-directed DNA polymerase DN407_30600 ENOG4105EKQ RNA-directed DNA polymerase DN407_30710 ENOG4105CNI cell division protein FtsW DN407_30715 ENOG4105CJW magnesium transporter DN407_30750 ENOG4105CNI cell division protein FtsW DN407_30770 ENOG4105C0H protease DN407_30815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN407_30820 ENOG4105BZU Histidine kinase DN407_30845 ENOG4105C0X amino acid DN407_30860 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN407_30870 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) DN407_30885 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN407_30945 ENOG4105D0M Protease HtpX homolog DN407_30985 ENOG4107R7I amino acid DN407_31000 ENOG4105CUB amino acid DN407_31050 ENOG4105XSJ toxin secretion phage lysis holin DN407_31060 ENOG4105CJW magnesium transporter DN407_31070 ENOG4105D7V transposase DN407_31075 ENOG4107VMI polysaccharide deacetylase DN407_31080 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DN407_31090 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DN407_31100 ENOG4105D7V transposase DN407_31135 ENOG4105DQ6 Transposase DN407_31165 ENOG4105EKQ RNA-directed DNA polymerase DN407_31250 ENOG4105CKI cobalamin synthesis protein DN407_31265 ENOG4105DSE periplasmic solute binding protein DN407_31270 ENOG4105DIK (ABC) transporter DN407_31290 ENOG4105DQ6 Transposase DN407_31295 ENOG4105DQ6 Transposase DN407_31310 ENOG4107YXZ hydrolase, family 25 DN407_31335 ENOG4105KRN Transcriptional regulator, abrb family DN407_31415 ENOG4107VMI polysaccharide deacetylase DN407_31570 ENOG4107R3N Filamentation induced by cAMP protein fic