locus-tag class description G4O42_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G4O42_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G4O42_00015 ENOG410848D S4 domain protein YaaA G4O42_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) G4O42_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4O42_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4O42_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G4O42_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) G4O42_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) G4O42_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G4O42_00095 ENOG4105BZW Glycerate kinase G4O42_00105 ENOG4105ZMH deoxynucleoside kinase G4O42_00115 ENOG4105VRS hydrolase family 18 G4O42_00120 ENOG4105GTG Isochorismatase G4O42_00125 ENOG4108Z6B deaminase G4O42_00135 ENOG4105C6E dna polymerase iii G4O42_00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G4O42_00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G4O42_00155 ENOG41067KS pro-sigma K processing G4O42_00195 ENOG4105CDW Resistance protein G4O42_00200 ENOG4105CXN decarboxylase G4O42_00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G4O42_00210 ENOG4105X0R protein from nitrogen regulatory protein P-II G4O42_00215 ENOG4105XVJ Protein of unknown function (DUF327) G4O42_00220 ENOG4105FA2 dna polymerase iii G4O42_00225 ENOG4105MA4 psp1 domain protein G4O42_00235 ENOG41060K3 Methyltransferase G4O42_00240 ENOG4105VC4 domain protein G4O42_00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G4O42_00250 ENOG4105KRN Transcriptional regulator, abrb family G4O42_00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G4O42_00260 ENOG4105F8V Hydrolase, tatD family G4O42_00265 ENOG41069ER domain protein G4O42_00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G4O42_00280 ENOG4105XFA sporulation peptidase YabG G4O42_00285 ENOG4105W42 Veg protein G4O42_00290 ENOG4105XEW small acid-soluble spore protein G4O42_00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G4O42_00300 ENOG4105DFT pur operon repressor G4O42_00305 ENOG4105KME endoribonuclease L-psp G4O42_00310 ENOG4105K4W Could be involved in septation (By similarity) G4O42_00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G4O42_00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G4O42_00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G4O42_00340 ENOG4108JA2 transcriptioN-repair coupling factor G4O42_00345 ENOG4108M14 stage v sporulation protein t G4O42_00355 ENOG4108IY2 MazG family G4O42_00360 ENOG41082I2 s4 domain protein G4O42_00365 ENOG4105VYY sporulation protein yabp G4O42_00380 ENOG41060GV RNA binding s1 domain protein G4O42_00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G4O42_00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase G4O42_00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G4O42_00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) G4O42_00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) G4O42_00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase G4O42_00440 ENOG4105C6T cysteine synthase G4O42_00445 ENOG4105CRQ synthase (Component I) G4O42_00450 ENOG4105DDQ anthranilate synthase G4O42_00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 G4O42_00460 ENOG4105EEI dihydropteroate synthase G4O42_00465 ENOG4105KRF dihydroneopterin aldolase G4O42_00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G4O42_00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G4O42_00485 ENOG4105CRK lysyL-tRNA synthetase G4O42_00570 ENOG4108Z0C Uvrb UvrC protein G4O42_00575 ENOG41066A3 ATP guanido phosphotransferase G4O42_00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G4O42_00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) G4O42_00595 ENOG4105CTP PilT protein domain protein G4O42_00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G4O42_00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G4O42_00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G4O42_00615 ENOG4105D7W serine acetyltransferase G4O42_00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) G4O42_00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 G4O42_00635 ENOG4105M0M Tetracycline resistance protein G4O42_00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G4O42_00670 ENOG4108VZM 50s ribosomal protein L10 G4O42_00680 ENOG4107Y49 methyltransferase G4O42_00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G4O42_00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G4O42_00695 ENOG4105XPM ribosomal protein G4O42_00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G4O42_00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G4O42_00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G4O42_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G4O42_00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase G4O42_00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G4O42_00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G4O42_00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G4O42_00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G4O42_00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G4O42_00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G4O42_00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G4O42_00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G4O42_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G4O42_00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G4O42_00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G4O42_00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G4O42_00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G4O42_00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G4O42_00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G4O42_00855 ENOG41067V7 50S ribosomal protein L36 G4O42_00860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G4O42_00865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G4O42_00870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G4O42_00875 ENOG4108ZT0 50S ribosomal protein l17 G4O42_00880 ENOG4108JJB ABC transporter G4O42_00885 ENOG4108JJB ABC transporter G4O42_00890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) G4O42_00895 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G4O42_00900 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G4O42_00905 ENOG4108UJD 30S ribosomal protein S9 G4O42_00910 ENOG4108I0C methyltransferase G4O42_00930 ENOG4105D1F ATP-binding protein G4O42_00945 ENOG4108NMV polysaccharide deacetylase G4O42_01010 ENOG4108JPW Aminotransferase G4O42_01020 ENOG4105CPQ Dehydrogenase G4O42_01025 ENOG4105CHH sulfate transporter G4O42_01035 ENOG4108SA1 esterase G4O42_01055 ENOG410874W AraC family transcriptional regulator G4O42_01060 ENOG4105EHZ conserved protein UCP016719 G4O42_01065 ENOG4105D17 glycoside hydrolase, family 3 domain protein G4O42_01080 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G4O42_01090 ENOG4105EWC Purine nucleoside phosphorylase G4O42_01120 ENOG4105EMN RNA polymerase sigma factor G4O42_01130 ENOG4105C8B TIGR00159 family G4O42_01135 ENOG4107U5W ybbr family G4O42_01140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G4O42_01165 ENOG4105BZU Histidine kinase G4O42_01170 ENOG4105C19 ABC transporter G4O42_01195 ENOG41067MG lrgb family G4O42_01205 ENOG41061AU MarR family Transcriptional regulator G4O42_01220 ENOG4105BZU Histidine kinase G4O42_01225 ENOG4105WH1 Two component transcriptional regulator luxr family G4O42_01230 ENOG4105CJ1 ABC, transporter G4O42_01255 ENOG4106DDH Sporulation-specific SASP protein G4O42_01270 ENOG4107QTZ amino acid G4O42_01275 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) G4O42_01290 ENOG4107VXM glycerophosphoryl diester phosphodiesterase G4O42_01295 ENOG4105CXY transporter G4O42_01330 ENOG41065RQ ADP-ribosylation crystallin J1 G4O42_01335 ENOG4106BHF G4O42_01345 ENOG4107SCQ Iron-containing alcohol dehydrogenase G4O42_01350 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR G4O42_01355 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G4O42_01360 ENOG4107ZTW SNARE associated Golgi G4O42_01375 ENOG4105C72 UPF0176 protein G4O42_01385 ENOG4105CM2 brancheD-chain amino acid aminotransferase G4O42_01390 ENOG4108IQI permease G4O42_01395 ENOG4108J5H Homocysteine s-methyltransferase G4O42_01405 ENOG4105CSV Glutaminase G4O42_01435 ENOG41076HS cation diffusion facilitator family transporter G4O42_01440 ENOG4108TVJ Nitroreductase G4O42_01445 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase G4O42_01450 ENOG4108VGI doxx family G4O42_01455 ENOG4105XXY Thioredoxin G4O42_01475 ENOG4105DGI Alkaline phosphatase G4O42_01480 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G4O42_01485 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G4O42_01490 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) G4O42_01495 ENOG4107EPV Aminotransferase class V G4O42_01500 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4O42_01505 ENOG4105J7D transcriptional regulator G4O42_01510 ENOG4107RB3 L-asparaginase G4O42_01515 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold G4O42_01520 ENOG41060AI SEC-C motif G4O42_01555 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G4O42_01565 ENOG4105DSE periplasmic solute binding protein G4O42_01570 ENOG4105DIK (ABC) transporter G4O42_01580 ENOG4105DEN Luciferase family G4O42_01585 ENOG4108N0M stress protein G4O42_01590 ENOG4106FN3 tellurium resistance protein G4O42_01595 ENOG4106FN3 tellurium resistance protein G4O42_01600 ENOG4107TS3 membrane protein, TerC G4O42_01605 ENOG4108TTB tellurium resistance protein G4O42_01615 ENOG41079KZ Major Facilitator Superfamily G4O42_01620 ENOG4108IJ7 Glycine betaine G4O42_01625 ENOG4107SQ8 Glycine betaine G4O42_01655 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G4O42_01685 ENOG4105EIG urea carboxylase-associated protein 1 G4O42_01690 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G4O42_01700 ENOG4105I1F Resistance protein G4O42_01705 ENOG4108WBH protein TIM barrel G4O42_01710 ENOG4105DJB Major Facilitator Superfamily G4O42_01715 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G4O42_01720 ENOG4105I82 acetyl xylan esterase G4O42_01725 ENOG410756H nucleotidyltransferase G4O42_01735 ENOG4105C26 Dehydrogenase G4O42_01740 ENOG4105CK7 Sodium proline symporter G4O42_01745 ENOG4107YHD transcriptional regulator G4O42_01750 ENOG4105CAY ferredoxin--nadp reductase G4O42_01755 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G4O42_01760 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit G4O42_01765 ENOG4108IFG nitrite reductase, (NAD(P)H) G4O42_01770 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G4O42_01785 ENOG4105CKI cobalamin synthesis protein G4O42_01790 ENOG4105E2A Dehydrogenase G4O42_01795 ENOG4105HHM rdd domain containing protein G4O42_01805 ENOG4105CS2 ec 3.2.1.21 G4O42_01825 ENOG41080HJ 6-phospho 3-hexuloisomerase G4O42_01830 ENOG4108VA3 3-hexulose-6-phosphate synthase G4O42_01835 ENOG4105KVH Transcriptional regulator G4O42_01840 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_01860 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) G4O42_01875 ENOG4105CDA abc transporter atp-binding protein G4O42_01880 ENOG4105DRP amino acid AbC transporter G4O42_01890 ENOG4106P55 Transcriptional regulator G4O42_01895 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G4O42_01900 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G4O42_01905 ENOG41069ZX G4O42_01910 ENOG41069ZX G4O42_01915 ENOG4105DUX Transporter G4O42_01930 ENOG4105E1K spore germination protein G4O42_01955 ENOG4105EAB amino acid AbC transporter G4O42_01960 ENOG4108HW4 amino acid AbC transporter G4O42_01975 ENOG4108PGP mmge prpd family protein G4O42_01985 ENOG4107WD8 ABC transporter, permease G4O42_01990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4O42_01995 ENOG4105BZU Histidine kinase G4O42_02015 ENOG4105CFH Aspartokinase G4O42_02020 ENOG4105DHS permease protein G4O42_02025 ENOG4105CM4 permease protein G4O42_02030 ENOG4108IPW abc transporter atp-binding protein G4O42_02045 ENOG4105R8C Transcriptional regulator G4O42_02050 ENOG4108DBC nitroreductase G4O42_02055 ENOG41067V3 Antibiotic biosynthesis monooxygenase G4O42_02060 ENOG4105YVS arsR family transcriptional regulator G4O42_02070 ENOG4108JPW Aminotransferase G4O42_02075 ENOG4105C26 Dehydrogenase G4O42_02085 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G4O42_02090 ENOG4105KTB nuclear export factor GLE1 G4O42_02095 ENOG4108T5E Copper resistance protein G4O42_02100 ENOG4108ZYE Transcriptional regulator G4O42_02120 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase G4O42_02140 ENOG4105E7W lamb ycsf family protein G4O42_02145 ENOG4105C5A transporter G4O42_02150 ENOG4105CFM UPF0317 protein G4O42_02155 ENOG4105P4J Allophanate hydrolase, subunit 1 G4O42_02165 ENOG4107258 Transcriptional regulator G4O42_02170 ENOG4105XJB lipolytic protein G-D-S-L family G4O42_02180 ENOG41061CK Antibiotic biosynthesis monooxygenase G4O42_02185 ENOG4107RVG penicillin-binding protein G4O42_02190 ENOG4107QM2 Aldo Keto reductase G4O42_02195 ENOG4105ETD TRANSCRIPTIONal G4O42_02205 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4O42_02220 ENOG410606W general stress protein G4O42_02230 ENOG4105VCH membrane G4O42_02240 ENOG4105C9U ATP-dependent DNA helicase RecQ G4O42_02255 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) G4O42_02260 ENOG4107R8N Glycosyl transferase, family 2 G4O42_02270 ENOG4105C0X amino acid G4O42_02330 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G4O42_02340 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) G4O42_02345 ENOG4105RXJ G4O42_02350 ENOG4105KPY Small multidrug resistance protein G4O42_02355 ENOG4105EU9 G4O42_02360 ENOG4105QVS general stress protein G4O42_02365 ENOG41082W1 Cupin 2, conserved barrel domain protein G4O42_02380 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G4O42_02385 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G4O42_02390 ENOG4108MRH transcriptional regulatory protein G4O42_02395 ENOG4107QJT sodium dicarboxylate symporter G4O42_02400 ENOG4106F5Q Membrane G4O42_02405 ENOG4105CJ1 ABC, transporter G4O42_02420 ENOG4105FDT acyl-CoA dehydrogenase G4O42_02440 ENOG4105SZ6 Thioredoxin G4O42_02445 ENOG4105CPF Cell wall formation (By similarity) G4O42_02450 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) G4O42_02455 ENOG4105C1J atp-dependent rna helicase G4O42_02460 ENOG410905X membrane-flanked domain protein G4O42_02465 ENOG4105CKV Membrane G4O42_02475 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G4O42_02480 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein G4O42_02485 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4O42_02495 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) G4O42_02500 ENOG4107MMM Anti-sigma-factor antagonist G4O42_02505 ENOG4105FUA antagonist G4O42_02510 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G4O42_02515 ENOG4107SGM protein serine threonine phosphatase G4O42_02520 ENOG4105WN5 stage II sporulation protein G4O42_02525 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G4O42_02535 ENOG41064BQ Phosphatase G4O42_02550 ENOG410906U SprT-like G4O42_02625 ENOG4105CSH Transporter G4O42_02630 ENOG4105K56 Transcriptional regulator G4O42_02640 ENOG4108ZMQ domain protein G4O42_02655 ENOG4108Z40 Transcriptional regulator G4O42_02660 ENOG4108RYK Nad-dependent epimerase dehydratase G4O42_02675 ENOG4105VEQ Cold shock protein G4O42_02680 ENOG4108VJ1 Transcriptional regulator (CarD family G4O42_02685 ENOG4105XTG Pfam:DUF156 G4O42_02690 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase G4O42_02695 ENOG4105C72 UPF0176 protein G4O42_02700 ENOG4105VFE sira family G4O42_02705 ENOG4107TPS domain protein G4O42_02710 ENOG4105VFE sira family G4O42_02715 ENOG41087NI Sulfite exporter TauE/SafE G4O42_02735 ENOG4105IRW patatin-like phospholipase family protein G4O42_02745 ENOG41082W1 Cupin 2, conserved barrel domain protein G4O42_02760 ENOG4105DNP FAD linked oxidase domain protein G4O42_02770 ENOG4105PGM cation diffusion facilitator family transporter G4O42_02775 ENOG4105H3G oxidoreductase G4O42_02785 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein G4O42_02825 ENOG4105DQ4 alcohol dehydrogenase G4O42_02830 ENOG4105VUF Transcriptional regulator G4O42_02840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4O42_02855 ENOG4105EQ0 Major Facilitator superfamily G4O42_02860 ENOG4108JGH Tetr family transcriptional regulator G4O42_02865 ENOG4105T38 integral membrane protein G4O42_02870 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4O42_02885 ENOG4105E2A Dehydrogenase G4O42_02890 ENOG4105PGS Spore coat protein G4O42_02900 ENOG4105ENE Histidine kinase G4O42_02905 ENOG4108VB1 regulatoR G4O42_02910 ENOG4105EYF MMPL domain protein G4O42_02930 ENOG4108JYZ YitT family G4O42_02940 ENOG4105C2C drug resistance transporter, Bcr CflA G4O42_02945 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G4O42_02965 ENOG41090E6 transcriptional regulator MERR family G4O42_02980 ENOG4105F2W methyltransferase G4O42_02985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G4O42_02990 ENOG4105DRR Transcriptional regulator, GntR family G4O42_03010 ENOG4105FQP Beta-lactamase G4O42_03015 ENOG41090UD (LipO)protein G4O42_03020 ENOG4108SUT Major Facilitator Superfamily G4O42_03025 ENOG4108TZY GntR Family Transcriptional Regulator G4O42_03030 ENOG4105JXH GntR family transcriptional regulator G4O42_03035 ENOG4105DJ2 Major Facilitator Superfamily G4O42_03055 ENOG4107QTZ amino acid G4O42_03075 ENOG4107QNK )-transporter G4O42_03115 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G4O42_03120 ENOG4105K8N protein family UPF0079, ATPase G4O42_03125 ENOG41072GX Peptidase M22 Glycoprotease G4O42_03130 ENOG410801F ribosomal-protein-alanine acetyltransferase G4O42_03135 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G4O42_03140 ENOG4105C5H ABC transporter G4O42_03145 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G4O42_03150 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) G4O42_03155 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G4O42_03160 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G4O42_03170 ENOG4108TYN CAAX amino terminal protease family protein G4O42_03180 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G4O42_03210 ENOG4105PGZ NB-ARC domain G4O42_03215 ENOG4105CPQ Dehydrogenase G4O42_03220 ENOG4105CT4 transporter G4O42_03235 ENOG41087YS Phage shock protein A G4O42_03240 ENOG4105DQX Zinc finger domain G4O42_03245 ENOG4108WV1 Pfam:DUF477 G4O42_03255 ENOG4105EXC Acyl-transferase G4O42_03260 ENOG4108P49 AntiSigma factor G4O42_03265 ENOG4105JVQ RNA Polymerase G4O42_03290 ENOG4107STQ Multicopper oxidase G4O42_03295 ENOG4105C85 amino acid G4O42_03300 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G4O42_03315 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G4O42_03335 ENOG4105C7N Xanthine uracil vitamin C permease G4O42_03360 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G4O42_03365 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G4O42_03370 ENOG4105C83 adenylosuccinate lyase G4O42_03375 ENOG4105C8V SAICAR synthetase G4O42_03380 ENOG4105VR9 phosphoribosylformylglycinamidine synthase G4O42_03385 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I G4O42_03390 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii G4O42_03400 ENOG4105CXB phosphoribosylaminoimidazole synthetase G4O42_03405 ENOG4108V3E phosphoribosylglycinamide formyltransferase G4O42_03410 ENOG4105DC1 bifunctional purine biosynthesis protein purh G4O42_03415 ENOG4105C12 Phosphoribosylglycinamide synthetase G4O42_03430 ENOG4108R5T secreted protein G4O42_03435 ENOG4105KGF protein, YerC YecD G4O42_03440 ENOG4105CBC glutamate synthase G4O42_03450 ENOG4105C4R Atp-dependent dna helicase G4O42_03455 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G4O42_03465 ENOG4105CRN Aminoglycoside phosphotransferase G4O42_03470 ENOG4105KT7 mgtC SapB transporter G4O42_03475 ENOG4105CK7 Sodium proline symporter G4O42_03480 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G4O42_03485 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G4O42_03490 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G4O42_03495 ENOG4108IG5 Transcriptional regulator G4O42_03505 ENOG4105CBD Diacylglycerol kinase G4O42_03510 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G4O42_03520 ENOG4105CJ1 ABC, transporter G4O42_03565 ENOG4105CDY transcriptional regulatory protein G4O42_03575 ENOG41075D4 Aminoglycoside 6-adenylyltransferase G4O42_03590 ENOG4105WEF catalase G4O42_03595 ENOG4105M18 -acetyltransferase G4O42_03605 ENOG4105H67 Protein of unknown function (DUF421) G4O42_03610 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) G4O42_03615 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily G4O42_03635 ENOG4106I4J membrane G4O42_03640 ENOG41082F9 transcriptional regulator G4O42_03645 ENOG41061H0 Monooxygenase G4O42_03650 ENOG4108R1P G4O42_03655 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4O42_03660 ENOG4105E0M Sulfatase G4O42_03665 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase G4O42_03675 ENOG41090R9 glycosyltransferase G4O42_03680 ENOG4107R51 Glycosyl transferase, family 2 G4O42_03685 ENOG41090R9 glycosyltransferase G4O42_03690 ENOG4105EU0 Major facilitator Superfamily G4O42_03695 ENOG4105CUB amino acid G4O42_03700 ENOG4105C26 Dehydrogenase G4O42_03705 ENOG4105FKZ Methyl-accepting chemotaxis G4O42_03710 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4O42_03715 ENOG4107TVC Glycosyl transferase, family 2 G4O42_03720 ENOG4105C5H ABC transporter G4O42_03725 ENOG4107SWG transcriptional regulator MERR family G4O42_03730 ENOG4105DXB Major Facilitator superfamily G4O42_03735 ENOG4105C5H ABC transporter G4O42_03740 ENOG4105FDU atp-dependent rna helicase G4O42_03750 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G4O42_03765 ENOG4108J20 pectate lyase G4O42_03770 ENOG4107QPK )-transporter G4O42_03795 ENOG4108MRH transcriptional regulatory protein G4O42_03820 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) G4O42_03825 ENOG4108RPX mosc domain containing protein G4O42_03845 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) G4O42_03885 ENOG4105C5Y PTS System G4O42_03890 ENOG4105CG3 alpha amylase, catalytic region G4O42_03895 ENOG4107414 GntR family transcriptional regulator G4O42_03900 ENOG4108RCM Nitroreductase G4O42_03915 ENOG4105CGH 5'-nucleotidase G4O42_03920 ENOG4107RKG DJ-1/PfpI family G4O42_03925 ENOG4105ETE Transcriptional regulator (LacI family G4O42_03935 ENOG4105FF2 Type I DHQase G4O42_03950 ENOG4105KJF protein tyrosine phosphatase G4O42_03960 ENOG4107U9T Pfam:Ribonuclease_BN G4O42_03965 ENOG4108ISG Major Facilitator G4O42_03970 ENOG4105UPD Calcium Proton G4O42_03980 ENOG4105D8X mechanosensitive ion channel G4O42_04015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4O42_04025 ENOG4106KE4 Dehydrogenase G4O42_04035 ENOG4105D7N magnesium and cobalt transport protein CorA G4O42_04045 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G4O42_04065 ENOG4107RUY (E1 component), alpha subunit G4O42_04075 ENOG4107QKR Dehydrogenase G4O42_04085 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G4O42_04095 ENOG4105F8D glycoside hydrolase family 4 G4O42_04100 ENOG4108Q3X Transcriptional regulator G4O42_04105 ENOG4105CI1 PTS System G4O42_04115 ENOG4105BZ1 (ABC) transporter G4O42_04120 ENOG4105BZ1 (ABC) transporter G4O42_04130 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase G4O42_04135 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G4O42_04140 ENOG4105U3E Transcriptional regulator G4O42_04145 ENOG4105DYS nad(p)h dehydrogenase (quinone) G4O42_04150 ENOG4105H93 Acyltransferase family G4O42_04165 ENOG4108YYS metal-dependent hydrolase (By similarity) G4O42_04170 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4O42_04175 ENOG410834F Transcriptional regulator G4O42_04185 ENOG4105JAB phenazine biosynthesis protein, phzf family G4O42_04190 ENOG4107Y03 Nitroreductase G4O42_04205 ENOG4105ECP epimerase G4O42_04210 ENOG410902V Modulates RecA activity (By similarity) G4O42_04220 ENOG4105F27 Major Facilitator G4O42_04230 ENOG4108TCS Glutamyl endopeptidase G4O42_04250 ENOG4106AKJ G4O42_04255 ENOG4105D74 hydrolase G4O42_04260 ENOG4105CKK Glycosyl transferase, family 2 G4O42_04265 ENOG4105EJV Membrane G4O42_04270 ENOG41067AE Membrane-bound metal-dependent hydrolase G4O42_04275 ENOG4105CEN a g-specific adenine glycosylase G4O42_04280 ENOG4106BXE G4O42_04285 ENOG4105CAN Short-chain dehydrogenase reductase Sdr G4O42_04305 ENOG4105BZ1 (ABC) transporter G4O42_04310 ENOG4107NBY Membrane G4O42_04315 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G4O42_04320 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4O42_04325 ENOG4105G5W regulator Fur family G4O42_04330 ENOG4105TUA UPF0295 protein G4O42_04440 ENOG4105EC3 peptidase S51, dipeptidase E G4O42_04445 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G4O42_04450 ENOG4105DNP FAD linked oxidase domain protein G4O42_04460 ENOG4105DEF Extracellular solute-binding protein, family 5 G4O42_04470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4O42_04475 ENOG4105C3U ABC transporter G4O42_04480 ENOG4108JQ7 (ABC) transporter G4O42_04495 ENOG4105E2Y ABC, transporter G4O42_04500 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein G4O42_04505 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G4O42_04515 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G4O42_04520 ENOG4107D63 G4O42_04525 ENOG4105VZ8 Transcriptional regulator G4O42_04540 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G4O42_04550 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G4O42_04570 ENOG4105CYN Serine protein kinase G4O42_04580 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G4O42_04585 ENOG4105CW7 secretion protein, HlyD family G4O42_04590 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4O42_04595 ENOG4105CS1 NAD(P)H quinone oxidoreductase G4O42_04610 ENOG4108TU7 Inherit from COG: (ABC) transporter G4O42_04615 ENOG4105VEQ Cold shock protein G4O42_04625 ENOG4105BZU Histidine kinase G4O42_04665 ENOG4108YBP pseudouridine synthase G4O42_04675 ENOG41080XP Cbs domain G4O42_04680 ENOG4107YBY Hydrolase G4O42_04685 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4O42_04690 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4O42_04695 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator G4O42_04705 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G4O42_04710 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G4O42_04720 ENOG4105BZU Histidine kinase G4O42_04725 ENOG4105WH1 Two component transcriptional regulator luxr family G4O42_04760 ENOG4105ED1 spovr family G4O42_04765 ENOG4105G6Z alkaline phosphatase G4O42_04780 ENOG4105BZN citrate synthase G4O42_04785 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4O42_04790 ENOG4105CUB amino acid G4O42_04795 ENOG4105C8J )-transporter G4O42_04805 ENOG4105J37 G4O42_04810 ENOG4108AEY RNA polymerase sigma factor G4O42_04815 ENOG4105F6E Acyl-transferase G4O42_04820 ENOG4105C37 (CBS) domain G4O42_04830 ENOG4105CHM Aminotransferase G4O42_04835 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase G4O42_04840 ENOG4105C37 (CBS) domain G4O42_04850 ENOG4105WMR Protein CrcB homolog G4O42_04855 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G4O42_04865 ENOG4105D64 Mechanosensitive ion channel G4O42_04870 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G4O42_04875 ENOG4107VMI polysaccharide deacetylase G4O42_04880 ENOG4105F0I Aminotransferase G4O42_04885 ENOG4105W1N transcriptional regulator G4O42_04890 ENOG4105IIP Membrane G4O42_04900 ENOG4105BZ1 (ABC) transporter G4O42_04905 ENOG4105BZ1 (ABC) transporter G4O42_04925 ENOG410839P G4O42_04935 ENOG4106MP8 UPF0754 membrane protein G4O42_04940 ENOG4105WZB UPF0342 protein G4O42_04945 ENOG4105F1N DNA alkylation repair G4O42_04955 ENOG4105D4P Coproporphyrinogen iii oxidase G4O42_04965 ENOG4107S91 Sodium hydrogen exchanger G4O42_04970 ENOG4105NCW Trka-c domain protein G4O42_04980 ENOG4105CGU Enoyl-CoA hydratase G4O42_04990 ENOG4108IUX (ABC) transporter G4O42_04995 ENOG4105RHA ABC transporter, permease G4O42_05000 ENOG4107VRP DNA repair exonuclease G4O42_05005 ENOG4106D4I domain protein G4O42_05010 ENOG4105EQI Metal Dependent Phosphohydrolase G4O42_05020 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G4O42_05065 ENOG4105NBU tryptophan transport protein G4O42_05070 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G4O42_05075 ENOG4105K59 histidine triad (HIT) protein G4O42_05105 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation G4O42_05110 ENOG4105BZ4 penicillin-binding protein G4O42_05115 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G4O42_05120 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G4O42_05125 ENOG4105C1Q protoporphyrinogen oxidase G4O42_05135 ENOG4105ECB domain protein G4O42_05150 ENOG4105DER m42 family G4O42_05160 ENOG4106AXD G4O42_05165 ENOG4108RQ5 Beta-lactamase domain-containing protein G4O42_05170 ENOG4105DF9 Lipoate-protein, ligase G4O42_05180 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_05190 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 G4O42_05205 ENOG4108HUF Transporter G4O42_05210 ENOG4107TB6 phosphoglycerate mutase G4O42_05220 ENOG4107F3J Amp-dependent synthetase and ligase G4O42_05225 ENOG4107ZYJ bioY protein G4O42_05230 ENOG4106YBV Methyl-accepting chemotaxis G4O42_05250 ENOG4105XVF Competence transcription factor G4O42_05260 ENOG4108ZMX Domain of unknown function (DU1801) G4O42_05270 ENOG4105X3H Excalibur domain protein G4O42_05275 ENOG4105K8R UPF0145 protein G4O42_05280 ENOG4105E1V na solute symporter G4O42_05285 ENOG4106CAD Protein of unknown function (DUF3311) G4O42_05290 ENOG41060YP G4O42_05305 ENOG4107SCK Monooxygenase G4O42_05310 ENOG4108INS Transcriptional regulator G4O42_05315 ENOG4108KK1 membrane protein AbrB duplication G4O42_05325 ENOG4108IG5 Transcriptional regulator G4O42_05335 ENOG4108QY0 Membrane G4O42_05340 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination G4O42_05345 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G4O42_05355 ENOG4105EYH Exonuclease G4O42_05400 ENOG4105ERH Fumarylacetoacetate hydrolase G4O42_05415 ENOG4105CAQ asparagine synthetase G4O42_05425 ENOG4105UQX Mate efflux family protein G4O42_05430 ENOG4106HBX Transcriptional Regulator AraC Family G4O42_05440 ENOG4105SF0 DinB family G4O42_05445 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G4O42_05450 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4O42_05455 ENOG4105MYW Pentapeptide repeat protein G4O42_05460 ENOG4105MA6 gCN5-related N-acetyltransferase G4O42_05470 ENOG4108VPT UPF0234 protein G4O42_05475 ENOG4105QNR S1 RNA binding domain protein G4O42_05480 ENOG4105DIH basic membrane G4O42_05485 ENOG4105C8Q Methyl-accepting chemotaxis G4O42_05490 ENOG4107E6A Cytochrome p-450 G4O42_05500 ENOG4105EPR degv family G4O42_05505 ENOG4107AYK membrAne G4O42_05515 ENOG41073B9 G4O42_05520 ENOG4108KP7 hydrolase G4O42_05525 ENOG4108MXZ Esterase G4O42_05530 ENOG4105VG1 fes assembly suf system protein G4O42_05535 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) G4O42_05540 ENOG4105IQ5 FAD linked oxidase domain protein G4O42_05550 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G4O42_05555 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G4O42_05560 ENOG4105CAS nag kinase G4O42_05565 ENOG4105C8Y Acetylornithine aminotransferase G4O42_05570 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G4O42_05580 ENOG4105DBV ornithine carbamoyltransferase G4O42_05605 ENOG4107RMD Basic membrane lipoprotein G4O42_05620 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G4O42_05625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G4O42_05635 ENOG4105C3U ABC transporter G4O42_05640 ENOG4108JQ7 (ABC) transporter G4O42_05655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4O42_05665 ENOG4105C31 Tryptophanyl-tRNA synthetase G4O42_05670 ENOG4108J59 Extracellular solute-binding protein, family 5 G4O42_05675 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4O42_05680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4O42_05690 ENOG4108JQ7 (ABC) transporter G4O42_05705 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) G4O42_05710 ENOG4108ZCF integral membrane protein G4O42_05715 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis G4O42_05725 ENOG4105DPN Oligoendopeptidase f G4O42_05730 ENOG4105T58 Dithiol-disulfide isomerase G4O42_05735 ENOG4108Z18 K06886 hemoglobin G4O42_05740 ENOG4105E4C Lytic transglycosylase catalytic G4O42_05745 ENOG4105MIX Adenylate cyclase G4O42_05760 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G4O42_05765 ENOG4105EMS pseudouridine synthase G4O42_05770 ENOG4107S1Q Phosphatase G4O42_05780 ENOG4105ETU transcriptional activator (TenA G4O42_05785 ENOG4108VEU Thiamine monophosphate synthase G4O42_05805 ENOG4105D06 uba thif-type nad fad binding protein G4O42_05810 ENOG4105DWF phosphomethylpyrimidine kinase G4O42_05815 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G4O42_05820 ENOG4107A88 G4O42_05870 ENOG4105ENA helicase G4O42_05890 ENOG4105CJ1 ABC, transporter G4O42_05905 ENOG4108ZMI UPF0477 protein G4O42_05915 ENOG4105C28 cystathionine G4O42_05920 ENOG4105C28 cystathionine G4O42_05950 ENOG4106BHF G4O42_05960 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase G4O42_05975 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4O42_05990 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase G4O42_05995 ENOG4105CMR udp-glucose 4-epimerase G4O42_06000 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G4O42_06005 ENOG4105CK1 PTS System G4O42_06010 ENOG4105VCP PTS System G4O42_06020 ENOG4105E98 transcriptional regulator DeoR family G4O42_06040 ENOG4105KT7 mgtC SapB transporter G4O42_06065 ENOG4108IEG Formate dehydrogenase Alpha subunit G4O42_06075 ENOG4106A3M Cytochrome p-450 G4O42_06080 ENOG41087PP glycosyltransferase MGT family G4O42_06090 ENOG4105EXQ uroporphyrinogen iii synthase hem4 G4O42_06095 ENOG4105C4B ABC transporter, permease G4O42_06100 ENOG4108IXI (ABC) transporter G4O42_06110 ENOG4105Q95 Cupin 2, conserved barrel domain protein G4O42_06125 ENOG4105D2H Uronic isomerase G4O42_06130 ENOG4105CT4 transporter G4O42_06135 ENOG4107KJX Transcriptional regulator G4O42_06140 ENOG4107QZW Altronate oxidoreductase G4O42_06145 ENOG4105CTX dehydratase G4O42_06155 ENOG4105F3H Histidine kinase G4O42_06175 ENOG4105BZU Histidine kinase G4O42_06195 ENOG4108JJA ABC, transporter G4O42_06205 ENOG4107TSN permease G4O42_06225 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase G4O42_06230 ENOG4105KWG Pfam:DUF1696 G4O42_06235 ENOG4105K7W phage-related replication protein G4O42_06240 ENOG410635T phage-like element pbsx protein G4O42_06280 ENOG4108TFU terminase (Small subunit) G4O42_06285 ENOG4105IG6 Phage terminase, large subunit G4O42_06290 ENOG4108MDF Phage Portal Protein G4O42_06315 ENOG41060SN G4O42_06330 ENOG4105PQS phage protein G4O42_06335 ENOG4105FR7 XkdM protein, phage-like element PBSX G4O42_06340 ENOG4105MTC XkdN-like protein G4O42_06350 ENOG4108FKH Transglycosylase SLT domain G4O42_06350 ENOG4108FKH Transglycosylase SLT domain G4O42_06350 ENOG4108FKH Transglycosylase SLT domain G4O42_06355 ENOG4108WZM domain protein G4O42_06360 ENOG4105X7F G4O42_06370 ENOG4105MFU Protein of unknown function (DUF2634) G4O42_06375 ENOG41066EA baseplate J family protein G4O42_06380 ENOG410906S phage-like element pbsx protein xkdt G4O42_06390 ENOG41068G1 G4O42_06420 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase G4O42_06435 ENOG4105CJ3 phosphate transporter G4O42_06440 ENOG4107GRR phosphate transport regulator G4O42_06445 ENOG4107R7I amino acid G4O42_06455 ENOG4105EDW glycosyl transferase, family 39 G4O42_06460 ENOG4105CKK Glycosyl transferase, family 2 G4O42_06465 ENOG4105C0H protease G4O42_06475 ENOG4108ME1 Peptidase M55 D-aminopeptidase G4O42_06480 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4O42_06485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4O42_06490 ENOG4105C3U ABC transporter G4O42_06500 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G4O42_06505 ENOG4105DTQ mandelate racemase muconate lactonizing G4O42_06510 ENOG4107SN7 NLP P60 protein G4O42_06515 ENOG4108JQ7 (ABC) transporter G4O42_06520 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G4O42_06525 ENOG4107TUM Amidinotransferase G4O42_06530 ENOG4108S4H thioesterase Superfamily protein G4O42_06535 ENOG4108428 Inherit from COG: -acetyltransferase G4O42_06545 ENOG41080TC multidrug resistance protein G4O42_06550 ENOG4105CIY formyltetrahydrofolate deformylase G4O42_06555 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G4O42_06570 ENOG4105K56 Transcriptional regulator G4O42_06575 ENOG4108ZHJ Organic hydroperoxide resistance protein G4O42_06590 ENOG4107TVC Glycosyl transferase, family 2 G4O42_06605 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G4O42_06610 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G4O42_06620 ENOG4108W7F transporter, permease G4O42_06625 ENOG4108JJB ABC transporter G4O42_06630 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein G4O42_06635 ENOG4105VRS hydrolase family 18 G4O42_06650 ENOG4105CJW magnesium transporter G4O42_06655 ENOG4105V75 Transcriptional regulator G4O42_06680 ENOG4105DQE DNA ligase G4O42_06685 ENOG4105FDF Could be involved in DNA repair (By similarity) G4O42_06690 ENOG4107T5V SNARE associated Golgi G4O42_06695 ENOG4107TS3 membrane protein, TerC G4O42_06700 ENOG4108WZW RNA polymerase sigma G4O42_06710 ENOG410681C small acid-soluble spore protein G4O42_06720 ENOG4105D0M Protease HtpX homolog G4O42_06730 ENOG410900G Protein of unknown function (DUF421) G4O42_06740 ENOG4108TGC Acyltransferase G4O42_06745 ENOG4105BZU Histidine kinase G4O42_06750 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4O42_06755 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G4O42_06765 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4O42_06775 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate G4O42_06780 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) G4O42_06785 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) G4O42_06790 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) G4O42_06800 ENOG4105BZU Histidine kinase G4O42_06805 ENOG41090MY MarR family Transcriptional regulator G4O42_06810 ENOG4105ER2 Ompa motb domain protein G4O42_06815 ENOG4105E14 MotA TolQ exbB proton channel G4O42_06825 ENOG4108K88 Membrane G4O42_06835 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G4O42_06840 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase G4O42_06845 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G4O42_06850 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G4O42_06865 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G4O42_06890 ENOG4105F0V Cell wall hydrolase G4O42_06905 ENOG4105C59 p-type ATPase G4O42_06910 ENOG4105DC7 peptidase M24 G4O42_06920 ENOG4105CID antiterminator G4O42_06930 ENOG4105KRI phosphocarrier protein (HPr G4O42_06935 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4O42_06945 ENOG4105F6S Spore photoproduct lyase G4O42_06950 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer G4O42_06955 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4O42_06960 ENOG4105K4I Scp-like extracellular G4O42_06970 ENOG4105BZU Histidine kinase G4O42_06975 ENOG4105CHM Aminotransferase G4O42_06980 ENOG4107R88 Chemotaxis protein (CheV) G4O42_06985 ENOG4105UIN G4O42_06995 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein G4O42_07005 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G4O42_07015 ENOG4105EPM Diguanylate phosphodiesterase G4O42_07020 ENOG4107IN1 Protein of unknown function (DUF1797) G4O42_07025 ENOG4108XRC Protein of unknown function (DUF458) G4O42_07055 ENOG4105NQC Flavodoxin G4O42_07075 ENOG4105D8X mechanosensitive ion channel G4O42_07080 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4O42_07095 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G4O42_07100 ENOG4105D06 uba thif-type nad fad binding protein G4O42_07105 ENOG4105CVM Molybdenum cofactor synthesis domain protein G4O42_07110 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein G4O42_07115 ENOG4108ZAF Molybdopterin G4O42_07120 ENOG41067WU Molybdopterin converting factor (Subunit 1) G4O42_07130 ENOG4107X8C Efflux transporter RND family MFP subunit G4O42_07135 ENOG4105C19 ABC transporter G4O42_07140 ENOG4107RBB ABC transporter, permease G4O42_07145 ENOG4105E98 transcriptional regulator DeoR family G4O42_07150 ENOG4105DE4 1-phosphofructokinase G4O42_07155 ENOG4105DM4 PTS System G4O42_07170 ENOG4105C5H ABC transporter G4O42_07175 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G4O42_07200 ENOG4105BZU Histidine kinase G4O42_07210 ENOG4107ZYR domain protein G4O42_07215 ENOG4105CPN adenine deaminase G4O42_07220 ENOG4105CN5 Metallo-Beta-Lactamase G4O42_07225 ENOG4106148 UPF0356 protein G4O42_07230 ENOG4108X4Q Hydrolase G4O42_07235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G4O42_07250 ENOG4107QKG PfaD family G4O42_07255 ENOG4105C0W non-ribosomal peptide synthetase G4O42_07260 ENOG4107SQU synthase G4O42_07265 ENOG4105C0W non-ribosomal peptide synthetase G4O42_07270 ENOG4107SQU synthase G4O42_07275 ENOG4107SQU synthase G4O42_07280 ENOG4107SQU synthase G4O42_07285 ENOG4105C0W non-ribosomal peptide synthetase G4O42_07290 ENOG4105FQP Beta-lactamase G4O42_07300 ENOG4105CPP Dehydrogenase, E1 component G4O42_07305 ENOG4105C7S Dehydrogenase G4O42_07310 ENOG4107QN2 dihydrolipoyl dehydrogenase G4O42_07330 ENOG4105CXN decarboxylase G4O42_07335 ENOG4105WBI UPF0223 protein G4O42_07350 ENOG4105ECY inositol monophosphatase G4O42_07360 ENOG4105D4Y metalloprotease G4O42_07385 ENOG4105CI3 gtp-binding protein typa G4O42_07390 ENOG4105QA2 G4O42_07405 ENOG4108IAB Phoh family G4O42_07415 ENOG4105CSV Glutaminase G4O42_07425 ENOG4105CNI cell division protein FtsW G4O42_07430 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G4O42_07440 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G4O42_07450 ENOG4105BZ9 Cytochrome C oxidase, subunit I G4O42_07455 ENOG4105CCU oxidase (Subunit III) G4O42_07460 ENOG41064X9 cytochrome C oxidase subunit IV G4O42_07475 ENOG41080XQ Signal transduction protein with cbs domains G4O42_07480 ENOG4106UY4 Inherit from COG: Scp-like extracellular G4O42_07505 ENOG4106H78 methyltransferase G4O42_07510 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G4O42_07515 ENOG4105H20 Sporulation integral membrane protein YlbJ G4O42_07520 ENOG4105D78 K07001 NTE family protein G4O42_07525 ENOG41063PX domain protein G4O42_07530 ENOG4105CDE UPF0348 protein G4O42_07535 ENOG4105KNH Nucleic acid-binding protein G4O42_07565 ENOG4108V6E Cell division protein mraZ G4O42_07570 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G4O42_07580 ENOG4105CJN penicillin-binding protein G4O42_07585 ENOG4105CJN penicillin-binding protein G4O42_07590 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G4O42_07595 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G4O42_07600 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G4O42_07605 ENOG4105CNI cell division protein FtsW G4O42_07610 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G4O42_07615 ENOG4105D4A Cell wall formation (By similarity) G4O42_07620 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) G4O42_07625 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G4O42_07630 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G4O42_07640 ENOG4105FFI sigma-e processing peptidase spoiiga G4O42_07645 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4O42_07655 ENOG4105DKW ABC transporter G4O42_07665 ENOG4105WR5 sporulation protein, YlmC YmxH family G4O42_07670 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G4O42_07675 ENOG4105DFA alanine racemase domain protein G4O42_07680 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) G4O42_07685 ENOG41067XK integral membrane protein G4O42_07690 ENOG4105DBK s4 domain protein G4O42_07700 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G4O42_07710 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G4O42_07715 ENOG4105C34 Pseudouridine synthase G4O42_07720 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G4O42_07730 ENOG4105CXT aspartate transcarbamylase G4O42_07740 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G4O42_07745 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G4O42_07750 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) G4O42_07755 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) G4O42_07760 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) G4O42_07765 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G4O42_07780 ENOG4107RIQ Sulfate adenylate transferase G4O42_07790 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G4O42_07795 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein G4O42_07800 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein G4O42_07815 ENOG4105DSJ YicC domain protein G4O42_07820 ENOG4105KC4 UPF0296 protein G4O42_07825 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G4O42_07835 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G4O42_07840 ENOG4105C25 Primosomal protein n' G4O42_07845 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G4O42_07850 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G4O42_07855 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G4O42_07860 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G4O42_07865 ENOG4108ZF3 Phosphatase G4O42_07870 ENOG4105D9P serine threonine protein kinase G4O42_07875 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G4O42_07880 ENOG4105DJV ribulose-phosphate 3-epimerase G4O42_07885 ENOG4105FJ0 thiamine G4O42_07895 ENOG4105VB9 50S ribosomal protein l28 G4O42_07900 ENOG4108ZAA Alkaline-shock protein G4O42_07905 ENOG4105DP4 dak2 domain fusion protein ylov G4O42_07915 ENOG4105EJQ L-serine dehydratase G4O42_07920 ENOG4105CB5 ATP-dependent DNA helicase recG G4O42_07925 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) G4O42_07930 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) G4O42_07935 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G4O42_07940 ENOG4105CHR reductase G4O42_07950 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G4O42_07955 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G4O42_07960 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G4O42_07970 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) G4O42_07980 ENOG4105K5M 30s ribosomal protein S16 G4O42_07985 ENOG4108BW8 UPF0109 protein G4O42_08000 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G4O42_08005 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G4O42_08010 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) G4O42_08015 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G4O42_08025 ENOG4105VM1 flagellar G4O42_08030 ENOG4105CMV Succinyl-CoA synthetase subunit beta G4O42_08035 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G4O42_08040 ENOG4105C79 DNA protecting protein DprA G4O42_08045 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G4O42_08050 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) G4O42_08055 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G4O42_08060 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G4O42_08065 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) G4O42_08075 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) G4O42_08080 ENOG4108ZC9 flagellar basal-body rod protein flgc G4O42_08085 ENOG4105VQ0 flagellar hook-basal body complex protein fliE G4O42_08090 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G4O42_08095 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4O42_08110 ENOG4106YF4 Flagellar biosynthesis chaperone G4O42_08120 ENOG410696Y Flagellar hook-length control protein G4O42_08125 ENOG410822I Flagellar hook capping protein G4O42_08130 ENOG4108JQA flagellar G4O42_08135 ENOG41068WV flagellar FlbD family protein G4O42_08145 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4O42_08150 ENOG4105DD5 Flagellar motor switch protein G4O42_08155 ENOG4107YTP response regulator receiver protein G4O42_08165 ENOG4105CN7 Flagellar biosynthetic protein FliP G4O42_08170 ENOG4105VS8 Flagellar biosynthetic protein fliq G4O42_08175 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G4O42_08180 ENOG4105D00 flagellar biosynthetic protein flhB G4O42_08185 ENOG4105D7B Flagellar biosynthesis protein flha G4O42_08190 ENOG4105FZW flagellar biosynthesis regulator FlhF G4O42_08200 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G4O42_08205 ENOG4105CBS Chea signal transduction histidine kinase G4O42_08210 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis G4O42_08220 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) G4O42_08225 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4O42_08235 ENOG4105CE9 30S ribosomal protein S2 G4O42_08245 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) G4O42_08250 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G4O42_08255 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G4O42_08260 ENOG4105KNE Phosphatidate cytidylyltransferase G4O42_08270 ENOG4105DZP Membrane-associated zinc metalloprotease G4O42_08275 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G4O42_08280 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) G4O42_08285 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G4O42_08290 ENOG4105CHV Transcription elongation factor NusA G4O42_08295 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination G4O42_08300 ENOG4105VHM ribosomal protein G4O42_08305 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G4O42_08310 ENOG4105W7A Protein of unknown function (DUF503) G4O42_08315 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G4O42_08320 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G4O42_08325 ENOG4105DTN riboflavin biosynthesis protein ribF G4O42_08330 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G4O42_08335 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G4O42_08345 ENOG4105C1V Peptidase, M16 G4O42_08355 ENOG4105E35 Dipicolinate synthase subunit A G4O42_08360 ENOG4108S0H Dipicolinic acid synthetase, b subunit G4O42_08365 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G4O42_08375 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4O42_08385 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit G4O42_08395 ENOG4105CNU cell division protein FtsK G4O42_08400 ENOG4105FDP GntR family transcriptional regulator G4O42_08415 ENOG4105EYF MMPL domain protein G4O42_08430 ENOG4108RKS Short-chain dehydrogenase reductase Sdr G4O42_08435 ENOG4105XZV Protein of unknown function (DUF3243) G4O42_08450 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase G4O42_08455 ENOG4105CEV competence damage-inducible protein G4O42_08460 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) G4O42_08465 ENOG4108A04 Beta-lactamase G4O42_08475 ENOG4105D48 metallophosphoesterase G4O42_08480 ENOG4105MCT stage V sporulation protein S G4O42_08485 ENOG4105CPQ Dehydrogenase G4O42_08490 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4O42_08495 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G4O42_08515 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G4O42_08525 ENOG4108151 Beta-lactamase domain protein G4O42_08530 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G4O42_08535 ENOG4108JA1 polyketide synthase G4O42_08540 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G4O42_08545 ENOG41062T2 Acyl carrier protein G4O42_08550 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase G4O42_08555 ENOG4108MGH Enoyl-CoA hydratase G4O42_08560 ENOG4108KQ6 Enoyl-CoA hydratase G4O42_08565 ENOG4105C0W non-ribosomal peptide synthetase G4O42_08570 ENOG4107SQU synthase G4O42_08580 ENOG4105C0W non-ribosomal peptide synthetase G4O42_08590 ENOG4106A3M Cytochrome p-450 G4O42_08595 ENOG4105WFK nuclease G4O42_08600 ENOG4105XPP Protein of unknown function (DUF1275) G4O42_08610 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G4O42_08620 ENOG4105K7W phage-related replication protein G4O42_08625 ENOG4108X3M OsmC Ohr family protein G4O42_08650 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G4O42_08675 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4O42_08680 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4O42_08685 ENOG4105U6W MutT NUDIX family protein G4O42_08690 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4O42_08700 ENOG4106F1P AAA ATPase, central domain protein G4O42_08705 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G4O42_08710 ENOG4105CXI aluminum resistance protein G4O42_08715 ENOG4105KV4 Transcriptional regulator G4O42_08720 ENOG4105C5F glutamine synthetase G4O42_08745 ENOG41064BW Protein of unknown function (DUF2568) G4O42_08760 ENOG4105CT4 transporter G4O42_08765 ENOG4105DSG hydrolase family 43 G4O42_08775 ENOG4105C93 Xylose Isomerase G4O42_08780 ENOG4105CMG Carbohydrate kinase G4O42_08785 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G4O42_08810 ENOG4105DQ4 alcohol dehydrogenase G4O42_08815 ENOG4105MXK Carbon dioxide concentrating mechanism protein G4O42_08855 ENOG4108M1A Chitin-binding protein G4O42_08880 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G4O42_08885 ENOG4105K7W phage-related replication protein G4O42_08905 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G4O42_08915 ENOG4108SVB resolvase G4O42_08920 ENOG4105VPS UPF0291 protein G4O42_08925 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4O42_08935 ENOG4105VXM UPF0154 protein G4O42_08945 ENOG4107QIV Cytochrome c biogenesis protein G4O42_08980 ENOG4108I0Z Aconitate hydratase G4O42_08985 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4O42_09000 ENOG41067CD Small, acid-soluble spore protein Tlp G4O42_09010 ENOG4105MI2 G4O42_09015 ENOG4105W8X HesB YadR YfhF-family protein G4O42_09020 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G4O42_09025 ENOG4105K4P CoA-binding domain protein G4O42_09030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4O42_09055 ENOG4105CPQ Dehydrogenase G4O42_09060 ENOG4108UHU Aldolase G4O42_09065 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) G4O42_09070 ENOG4105DMW Dehydrogenase reductase G4O42_09080 ENOG4108I5G Major Facilitator superfamily G4O42_09095 ENOG4105FVX G4O42_09130 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4O42_09140 ENOG4107SYN Glycosyl hydrolases family 43 G4O42_09165 ENOG4105DTD Dehydrogenase G4O42_09170 ENOG4108IIH CoA-transferase subunit B G4O42_09175 ENOG4105D6N CoA-transferase, subunit a G4O42_09180 ENOG4105CY2 Citrate transporter G4O42_09185 ENOG4106A3M Cytochrome p-450 G4O42_09190 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G4O42_09195 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G4O42_09200 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4O42_09205 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4O42_09210 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) G4O42_09225 ENOG4107T5V SNARE associated Golgi G4O42_09230 ENOG4107QX3 carboxylase G4O42_09235 ENOG4105E39 Enoyl-CoA hydratase G4O42_09240 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G4O42_09245 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G4O42_09250 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G4O42_09255 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_09260 ENOG4105C1G acyl-Coa dehydrogenase G4O42_09265 ENOG4105F32 YngK protein G4O42_09270 ENOG4106U2H Protein of unknown function (DUF1360) G4O42_09280 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_09285 ENOG4105C0W non-ribosomal peptide synthetase G4O42_09295 ENOG4105C0W non-ribosomal peptide synthetase G4O42_09300 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family G4O42_09305 ENOG4108N2V aldose 1-epimerase G4O42_09310 ENOG4107QJQ Mate efflux family protein G4O42_09335 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G4O42_09340 ENOG4108RWP Major Facilitator Superfamily protein G4O42_09345 ENOG4105WAB arsR family transcriptional regulator G4O42_09350 ENOG4105C22 threonyL-tRNA synthetase G4O42_09355 ENOG4108KSA LysR family transcriptional regulator G4O42_09360 ENOG4105CB2 alcohol dehydrogenase G4O42_09365 ENOG4105BZ8 glutamate synthase G4O42_09370 ENOG4105CBC glutamate synthase G4O42_09375 ENOG4105C5Q Transcriptional regulator G4O42_09380 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G4O42_09405 ENOG4108UB7 G4O42_09410 ENOG4105IE8 Alpha-ketoglutarate permease G4O42_09415 ENOG4107U6E carbohydrate kinase FGGY G4O42_09420 ENOG4108M3J Dehydrogenase G4O42_09425 ENOG4108J2R molybdopterin oxidoreductase G4O42_09450 ENOG4106ANW SMI1_KNR4 G4O42_09455 ENOG4106BHF G4O42_09460 ENOG4108Z7R Chaperone CsaA G4O42_09465 ENOG4105FTV AraC Family Transcriptional Regulator G4O42_09475 ENOG4108W8B Beta-lactamase domain protein G4O42_09485 ENOG4105KTU Transcriptional regulator, arsr family G4O42_09495 ENOG4108SJC Membrane G4O42_09520 ENOG41069ER domain protein G4O42_09525 ENOG4105C9U ATP-dependent DNA helicase RecQ G4O42_09535 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G4O42_09540 ENOG4105SCY DNAK suppressor G4O42_09585 ENOG4105C26 Dehydrogenase G4O42_09590 ENOG4105EWU Squalene--hopene cyclase G4O42_09595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4O42_09600 ENOG4105C8J )-transporter G4O42_09605 ENOG4105C09 Bile acid G4O42_09615 ENOG4105C7S Dehydrogenase G4O42_09620 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G4O42_09625 ENOG4107T89 von Willebrand factor, type A G4O42_09630 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G4O42_09640 ENOG4105K4H Nlp p60 protein G4O42_09645 ENOG41087PP glycosyltransferase MGT family G4O42_09655 ENOG4107QMU Mate efflux family protein G4O42_09660 ENOG4106SCS STAS domain G4O42_09680 ENOG4105FR1 rard protein G4O42_09695 ENOG41090U3 tautomerase G4O42_09715 ENOG4105FBA Phospholipase Carboxylesterase G4O42_09730 ENOG4105E1V na solute symporter G4O42_09740 ENOG4105CS2 ec 3.2.1.21 G4O42_09745 ENOG4108S3Y transcriptional regulator G4O42_09765 ENOG4108VXD carboxy-peptidase G4O42_09770 ENOG4105D3A purine nucleoside phosphorylase DeoD-type G4O42_09780 ENOG4106Z5R G4O42_09785 ENOG410841Q phosphoesterase PA-phosphatase related protein G4O42_09810 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G4O42_09815 ENOG4108TSC N-acetyltransferase G4O42_09820 ENOG4107S4Y M20 DapE family protein YgeY G4O42_09835 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4O42_09840 ENOG4105FTQ Dna gyrase G4O42_09940 ENOG4106ANW SMI1_KNR4 G4O42_09945 ENOG4106BHF G4O42_09955 ENOG4107Y9E nuclease G4O42_09970 ENOG4105E0X reductase G4O42_09975 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G4O42_09985 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) G4O42_09990 ENOG41090WU lipolytic protein G-D-S-L family G4O42_09995 ENOG4108KF3 Electron transport protein SCO1 SenC G4O42_10005 ENOG4105C7B Threonine dehydratase G4O42_10015 ENOG4108UT2 hemolysin iii G4O42_10025 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G4O42_10030 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G4O42_10040 ENOG4107YX5 Pfam:DUF548 G4O42_10045 ENOG4108Y6J UPF0403 protein G4O42_10050 ENOG4105C01 Dihydroxy-acid dehydratase G4O42_10065 ENOG4108V06 Glutathione peroxidase G4O42_10070 ENOG4105CVG Homoserine O-transsuccinylase G4O42_10115 ENOG41081VK Ribonuclease G4O42_10140 ENOG410890F Dynamin family G4O42_10155 ENOG41065KQ synthase G4O42_10185 ENOG4105C2W permease G4O42_10190 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) G4O42_10195 ENOG4105CTD carboxy-peptidase G4O42_10200 ENOG4105DVT helicase G4O42_10215 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G4O42_10225 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) G4O42_10230 ENOG4108UKS UPF0398 protein G4O42_10245 ENOG4107X2U Inherit from COG: Exonuclease-like protein G4O42_10250 ENOG4108I5C dEAD DEAH box helicase G4O42_10295 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) G4O42_10300 ENOG4105BZ4 penicillin-binding protein G4O42_10310 ENOG4105CSM endonuclease III G4O42_10320 ENOG4105C5S asparaginyl-tRNA synthetase G4O42_10325 ENOG4105CHM Aminotransferase G4O42_10335 ENOG4105YAC G4O42_10340 ENOG4105DVT helicase G4O42_10345 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G4O42_10355 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G4O42_10365 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G4O42_10370 ENOG4105CPK Glycosyl transferase (Group 1 G4O42_10375 ENOG4105FJR Lmbe family G4O42_10380 ENOG4108Z5K methylglyoxal synthase G4O42_10385 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G4O42_10390 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase G4O42_10395 ENOG4108JYZ YitT family G4O42_10420 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G4O42_10440 ENOG41068YB TPR repeat-containing protein G4O42_10445 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G4O42_10455 ENOG4105CIH Imidazole acetol-phosphate transaminase G4O42_10465 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G4O42_10470 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G4O42_10475 ENOG4105DK0 Indole-3-glycerol phosphate synthase G4O42_10485 ENOG4105CRQ synthase (Component I) G4O42_10490 ENOG4105KHN chorismate mutase G4O42_10500 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G4O42_10505 ENOG4105BZU Histidine kinase G4O42_10510 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G4O42_10515 ENOG4105EAH synthase G4O42_10520 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G4O42_10525 ENOG4105XXQ heptaprenyl diphosphate synthase component I G4O42_10530 ENOG4105WP2 Tryptophan RNA-binding attenuator protein G4O42_10535 ENOG4105EUJ GTP cyclohydrolase i G4O42_10540 ENOG4105K70 DNA-binding protein G4O42_10545 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) G4O42_10560 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G4O42_10565 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G4O42_10585 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G4O42_10590 ENOG4105CAT Cytidine monophosphate kinase G4O42_10605 ENOG4105MSI germination protein ypeb G4O42_10615 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) G4O42_10620 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase G4O42_10635 ENOG4107RGJ metallophosphoesterase G4O42_10650 ENOG4105I7S Abortive infection protein G4O42_10655 ENOG4105C9U ATP-dependent DNA helicase RecQ G4O42_10660 ENOG4105T7X G4O42_10670 ENOG4108SAX Membrane G4O42_10675 ENOG4108JQ1 Dehydrogenase G4O42_10690 ENOG4105BZU Histidine kinase G4O42_10695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4O42_10700 ENOG4105CRE cytochrome C G4O42_10705 ENOG4107TWT Cytochrome c biogenesis protein G4O42_10715 ENOG4105FE9 pseudouridine synthase G4O42_10725 ENOG4108JIC nucleoside recognition domain protein G4O42_10730 ENOG4105DZ1 carboxypeptidase G4O42_10740 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G4O42_10745 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G4O42_10765 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G4O42_10770 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G4O42_10775 ENOG4108R6K riboflavin synthase, subunit alpha G4O42_10800 ENOG4107ZE5 PPIases accelerate the folding of proteins G4O42_10805 ENOG4105PTM secreted protein G4O42_10810 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G4O42_10820 ENOG4105G6R Stage v sporulation protein ae G4O42_10830 ENOG4105CZ3 stage V sporulation protein ad G4O42_10835 ENOG41090VF Stage v sporulation protein ac G4O42_10850 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4O42_10855 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G4O42_10860 ENOG41082AN stage II sporulation protein G4O42_10865 ENOG4105DZ1 carboxypeptidase G4O42_10870 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) G4O42_10875 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) G4O42_10880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G4O42_10890 ENOG4105I3K Ferric uptake regulator, Fur family G4O42_10895 ENOG4105MZ9 stage II sporulation protein m G4O42_10915 ENOG4105DFD Na H antiporter G4O42_10920 ENOG4108IJ0 Aspartate ammonia-lyase G4O42_10925 ENOG4105HDK L-asparaginase G4O42_10930 ENOG4108IMY Transcriptional regulator G4O42_10940 ENOG4108YZ4 nudix hydrolase G4O42_10950 ENOG4105CPC Aldo Keto reductase G4O42_10970 ENOG4106HZJ G4O42_10975 ENOG4105RHY Pfam:UPF0157 G4O42_10980 ENOG4105KAC Antibiotic biosynthesis monooxygenase G4O42_10985 ENOG4108XET gCN5-related N-acetyltransferase G4O42_10990 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G4O42_11005 ENOG4105C02 permease G4O42_11015 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase G4O42_11020 ENOG4105CS9 pantothenic acid kinase G4O42_11030 ENOG4108IXY short-chain dehydrogenase reductase G4O42_11035 ENOG41069FQ Metallo-beta-lactamase superfamily G4O42_11040 ENOG4105II7 pyrroline-5-carboxylate reductase G4O42_11045 ENOG4108KQ6 Enoyl-CoA hydratase G4O42_11050 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase G4O42_11055 ENOG4106A3M Cytochrome p-450 G4O42_11070 ENOG4105C0W non-ribosomal peptide synthetase G4O42_11075 ENOG4105C0W non-ribosomal peptide synthetase G4O42_11085 ENOG4105C0W non-ribosomal peptide synthetase G4O42_11095 ENOG4105CHR reductase G4O42_11100 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_11115 ENOG4107QKG PfaD family G4O42_11120 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G4O42_11125 ENOG4108K70 Transcriptional regulator G4O42_11135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4O42_11145 ENOG410861F 50S ribosomal protein L33 G4O42_11150 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G4O42_11155 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G4O42_11160 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G4O42_11165 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G4O42_11175 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) G4O42_11180 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) G4O42_11185 ENOG4108HNZ carboxyl transferase G4O42_11190 ENOG4108ZVT methylmalonyl-coA epimerase G4O42_11205 ENOG4108QEG Membrane G4O42_11210 ENOG4105CDA abc transporter atp-binding protein G4O42_11215 ENOG4105E5Q amino acid AbC transporter G4O42_11220 ENOG4108HW3 (ABC) transporter G4O42_11225 ENOG4108Y6J UPF0403 protein G4O42_11230 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) G4O42_11235 ENOG4105C7S Dehydrogenase G4O42_11240 ENOG4105CPP Dehydrogenase, E1 component G4O42_11255 ENOG4105CKM Branched-chain carboxylic acid kinase G4O42_11260 ENOG4107RDP Dehydrogenase G4O42_11270 ENOG4108JUB Transcriptional regulator G4O42_11275 ENOG4106CCJ Protein of unknown function (DUF2627) G4O42_11280 ENOG4105CR4 methylisocitrate lyase G4O42_11285 ENOG4105DXD 2-methylcitrate dehydratase G4O42_11295 ENOG4105C1G acyl-Coa dehydrogenase G4O42_11300 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G4O42_11310 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G4O42_11315 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4O42_11335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4O42_11350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4O42_11355 ENOG4107QQR Sporulation G4O42_11360 ENOG4105S1Z Stage IV sporulation protein B G4O42_11365 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G4O42_11370 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) G4O42_11375 ENOG4105DX0 Hemolysin A G4O42_11380 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G4O42_11385 ENOG4105CTB Polyprenyl synthetase G4O42_11390 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G4O42_11395 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G4O42_11400 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G4O42_11405 ENOG4105M7K Involved in the transcription termination process (By similarity) G4O42_11410 ENOG4108ZSR alkaline shock protein G4O42_11415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G4O42_11435 ENOG410644B Stage III sporulation protein af G4O42_11445 ENOG4105KQ4 Stage iii sporulation protein ad G4O42_11450 ENOG4108CQH stage III sporulation protein AC G4O42_11455 ENOG4105KR5 Stage iii sporulation protein G4O42_11460 ENOG4105CD2 stage iii sporulation protein aa G4O42_11470 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G4O42_11475 ENOG4105DC7 peptidase M24 G4O42_11485 ENOG4105CBJ Metal-dependent enzyme G4O42_11505 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) G4O42_11510 ENOG4105WZW rhodanese family G4O42_11515 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G4O42_11525 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G4O42_11530 ENOG4105C0D helicase G4O42_11545 ENOG4108IMY Transcriptional regulator G4O42_11555 ENOG4105VFR signal peptidase G4O42_11615 ENOG4105C37 (CBS) domain G4O42_11640 ENOG4105C5X domain protein G4O42_11685 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G4O42_11700 ENOG41068DG YceG-like family G4O42_11705 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G4O42_11710 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G4O42_11715 ENOG4105E2Z phosphate ABC transporter (Permease G4O42_11720 ENOG4105C8U phosphate abc transporter G4O42_11725 ENOG4105CVA phosphate G4O42_11730 ENOG4107RF6 penicillin-binding protein G4O42_11740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4O42_11745 ENOG4105SXS Protein of unknown function (DUF456) G4O42_11760 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G4O42_11765 ENOG41063Y9 G4O42_11770 ENOG4108U5J '-nucleotidase G4O42_11775 ENOG4105N80 Ferric uptake regulator, Fur family G4O42_11780 ENOG4108JYZ YitT family G4O42_11785 ENOG41069ZM Protein of unknown function (DUF2624) G4O42_11790 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) G4O42_11805 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G4O42_11810 ENOG4105EGD dinuclear metal center protein, YbgI family G4O42_11825 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4O42_11830 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G4O42_11835 ENOG4108UPT UPF0178 protein G4O42_11840 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) G4O42_11850 ENOG4105C38 Glycyl-tRNA synthetase beta subunit G4O42_11855 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit G4O42_11860 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G4O42_11870 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G4O42_11875 ENOG4105KG3 cytidine deaminase G4O42_11880 ENOG4107YR5 Diacylglycerol kinase G4O42_11885 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G4O42_11890 ENOG4105CTJ Metal Dependent Phosphohydrolase G4O42_11895 ENOG4105C9A Phoh family G4O42_11900 ENOG4105EI1 sporulation protein yqfd G4O42_11905 ENOG41068P3 sporulation protein YqfC G4O42_11915 ENOG4105DI5 UPF0365 protein G4O42_11920 ENOG4105F7J membrane-bound serine protease G4O42_11925 ENOG4105KTH gatB Yqey G4O42_11940 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G4O42_11945 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G4O42_11950 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G4O42_11955 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) G4O42_11960 ENOG4105CFG Acts as a chaperone (By similarity) G4O42_11965 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G4O42_11970 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G4O42_11975 ENOG4105CSA Coproporphyrinogen iii oxidase G4O42_11980 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G4O42_11990 ENOG4108ZRV stage ii sporulation protein p G4O42_11995 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) G4O42_12000 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) G4O42_12005 ENOG4105TQK DNA polymerase iii, delta' subunit G4O42_12020 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 G4O42_12025 ENOG4108UK2 deaminase G4O42_12030 ENOG4105KQC Competence protein G4O42_12040 ENOG4108D32 Methyltransferase G4O42_12050 ENOG4108WF2 Metal Dependent Phosphohydrolase G4O42_12055 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G4O42_12060 ENOG410812S Rna-binding protein G4O42_12065 ENOG4105E2X shikimate dehydrogenase G4O42_12070 ENOG4105CQW ribosome biogenesis GTPase YqeH G4O42_12075 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase G4O42_12095 ENOG41080BT SNARE associated Golgi G4O42_12110 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4O42_12135 ENOG4105KVH Transcriptional regulator G4O42_12210 ENOG4108SWU Histidine kinase G4O42_12215 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4O42_12220 ENOG4105DHF Membrane G4O42_12230 ENOG4108UYN gCN5-related N-acetyltransferase G4O42_12235 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G4O42_12245 ENOG4108J8C transporter major facilitator family protein G4O42_12255 ENOG4108U7W acetyltransferase G4O42_12270 ENOG4108HCJ Hydrolase G4O42_12275 ENOG4108HCJ Hydrolase G4O42_12285 ENOG4105DG6 mannose-6-phosphate isomerase G4O42_12290 ENOG4105DM4 PTS System G4O42_12305 ENOG4108Z66 YbaK ebsC protein G4O42_12310 ENOG4107RSM transcriptional regulator G4O42_12315 ENOG4105D94 Major Facilitator Superfamily G4O42_12320 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4O42_12325 ENOG41082JN Transcriptional regulator G4O42_12340 ENOG4105TMB Formate nitrite transporter G4O42_12345 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) G4O42_12350 ENOG4108JB9 formate dehydrogenase G4O42_12365 ENOG4105C28 cystathionine G4O42_12395 ENOG4107XRG penicillin-binding protein G4O42_12400 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G4O42_12410 ENOG4105CFP Peptidase U32 G4O42_12415 ENOG4105XYU peptidase (U32 family) G4O42_12425 ENOG4105HHA aminodeoxychorismate lyase G4O42_12435 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G4O42_12440 ENOG4105VBH UPF0297 protein G4O42_12445 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G4O42_12450 ENOG4105C02 permease G4O42_12455 ENOG4105CDA abc transporter atp-binding protein G4O42_12460 ENOG4105CT1 (ABC) transporter G4O42_12465 ENOG4105EAD ABC transporter G4O42_12470 ENOG4105DRP amino acid AbC transporter G4O42_12480 ENOG41060CR G4O42_12490 ENOG4105C7H Helicase, RecD TraA family G4O42_12500 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G4O42_12505 ENOG4105C3J Cysteine desulfurase G4O42_12515 ENOG4105D1H recombination factor protein RarA G4O42_12520 ENOG4105CUZ uba thif-type nad fad binding protein G4O42_12530 ENOG4105C9M aspartyl-trna synthetase G4O42_12535 ENOG4105CUT histidyl-tRNA synthetase G4O42_12545 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4O42_12550 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) G4O42_12555 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G4O42_12565 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G4O42_12570 ENOG41067VP Protein of unknown function (DUF1049) G4O42_12575 ENOG4105NCW Trka-c domain protein G4O42_12580 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G4O42_12590 ENOG4105CKP Polysaccharide Biosynthesis Protein G4O42_12595 ENOG4108QG2 Membrane G4O42_12600 ENOG4105NAP G4O42_12605 ENOG4105VIE preprotein translocase, subunit YajC G4O42_12610 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) G4O42_12615 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G4O42_12620 ENOG41061AI Protein of unknown function (DUF2905) G4O42_12625 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G4O42_12630 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G4O42_12645 ENOG4106678 morphogenetic protein associated with SpoVID G4O42_12650 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G4O42_12655 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G4O42_12660 ENOG4108IYU L-aspartate oxidase G4O42_12675 ENOG4105CQC Prephenate dehydratase G4O42_12685 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G4O42_12695 ENOG4105K46 50S ribosomal protein l27 G4O42_12700 ENOG4105X36 (ribosomal) protein G4O42_12705 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G4O42_12720 ENOG4107QMS site-determining protein G4O42_12725 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G4O42_12730 ENOG4105YHC Rod shape-determining protein MreD G4O42_12740 ENOG4105DFF Rod shape-determining protein mreb G4O42_12745 ENOG4105W5Q DNA repair protein (RadC G4O42_12750 ENOG4108Z03 MAF-like protein G4O42_12760 ENOG4106A3R peptidase G4O42_12765 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G4O42_12770 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G4O42_12780 ENOG4106AR7 Spore coat protein G4O42_12785 ENOG41068KH stage VI sporulation protein D G4O42_12790 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G4O42_12795 ENOG4105D52 delta-aminolevulinic acid dehydratase G4O42_12805 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G4O42_12815 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G4O42_12825 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) G4O42_12830 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G4O42_12835 ENOG4108IUQ atp-dependent protease G4O42_12840 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G4O42_12845 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G4O42_12855 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G4O42_12860 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G4O42_12865 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G4O42_12875 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G4O42_12880 ENOG4108ZP8 Acetolactate synthase small subunit G4O42_12885 ENOG4105C7K acetolactate synthase G4O42_12910 ENOG4105M59 Phosphodiesterase, mj0936 family G4O42_12915 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G4O42_12920 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G4O42_12925 ENOG4108XJQ germination protein G4O42_12930 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G4O42_12935 ENOG41067TZ transcriptional regulator, MarR family G4O42_12940 ENOG4105PFC Transcriptional regulator G4O42_12945 ENOG4107Y5K Resolvase G4O42_12950 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G4O42_12980 ENOG4106BHF G4O42_13000 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase G4O42_13020 ENOG41068G1 G4O42_13060 ENOG4108FKH Transglycosylase SLT domain G4O42_13145 ENOG4107KNS G4O42_13240 ENOG4108PNI recT protein G4O42_13245 ENOG4108NF7 phage-type endonuclease G4O42_13275 ENOG4105WXW Antirepressor G4O42_13290 ENOG41067QW Transcriptional regulator G4O42_13295 ENOG4107Y9E nuclease G4O42_13310 ENOG4105PFC Transcriptional regulator G4O42_13320 ENOG4105E33 succinate dehydrogenase G4O42_13330 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit G4O42_13340 ENOG4105CFH Aspartokinase G4O42_13345 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G4O42_13350 ENOG4105K63 Thioredoxin G4O42_13355 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) G4O42_13360 ENOG4105C10 Electron transfer flavoprotein G4O42_13365 ENOG4105BZJ Electron transfer flavoprotein G4O42_13370 ENOG41060WC Enoyl-CoA hydratase G4O42_13375 ENOG4107Z3H Transcriptional regulator, TetR family G4O42_13380 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_13395 ENOG4105C98 muts2 protein G4O42_13400 ENOG4105DCG PHP domain protein G4O42_13415 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G4O42_13420 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G4O42_13425 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G4O42_13430 ENOG4108RWN rrna methyltransferase G4O42_13435 ENOG41067MF small acid-soluble spore protein G4O42_13445 ENOG4105CQB FAD linked oxidase domain protein G4O42_13450 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4O42_13460 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) G4O42_13465 ENOG4105DRS transport system, permease G4O42_13480 ENOG4108MDK Dehydrogenase G4O42_13490 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4O42_13495 ENOG4105EF1 ribulokinase G4O42_13505 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase G4O42_13510 ENOG4105CN9 Peptidase m42 family protein G4O42_13520 ENOG410696E Membrane G4O42_13525 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G4O42_13530 ENOG4105VJV 50s ribosomal protein L35 G4O42_13535 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G4O42_13540 ENOG41067MG lrgb family G4O42_13550 ENOG4105DY9 regulatoR G4O42_13555 ENOG4108HRK Histidine kinase G4O42_13565 ENOG4105C22 threonyL-tRNA synthetase G4O42_13570 ENOG4108TDW sporulation protein YtxC G4O42_13595 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G4O42_13600 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4O42_13605 ENOG4105KVH Transcriptional regulator G4O42_13610 ENOG4105F27 Major Facilitator G4O42_13615 ENOG4105CV8 reductase G4O42_13620 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G4O42_13630 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G4O42_13635 ENOG4105C2M dna polymerase I G4O42_13640 ENOG4105BZU Histidine kinase G4O42_13645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4O42_13655 ENOG4108HMX isocitrate dehydrogenase (NADP) G4O42_13660 ENOG4105BZN citrate synthase G4O42_13675 ENOG4105G7B Protein of unknown function (DUF2992) G4O42_13685 ENOG4108REF Sporulation integral membrane protein ytvi G4O42_13690 ENOG4105FS0 cytoplasmic membrane protein G4O42_13695 ENOG4105CA9 Pyruvate kinase G4O42_13700 ENOG4105CTQ phosphohexokinase G4O42_13705 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G4O42_13710 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) G4O42_13715 ENOG4105C6K Malic enzyme G4O42_13720 ENOG4105C0B DNA polymerase III (alpha subunit) G4O42_13725 ENOG4105VV2 G4O42_13735 ENOG4106EVM G4O42_13740 ENOG4105SFS phosphoesterase RecJ domain protein G4O42_13755 ENOG4105E8R UPF0173 metal-dependent hydrolase G4O42_13765 ENOG4105CH7 arginosuccinase G4O42_13770 ENOG4105CDH Citrulline--aspartate ligase G4O42_13775 ENOG4105EPU Molybdenum cofactor synthesis domain protein G4O42_13780 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G4O42_13790 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) G4O42_13795 ENOG4105KBJ sporulation protein ytfj G4O42_13805 ENOG4105VK3 rdd domain containing protein G4O42_13810 ENOG4105D07 Signal peptide peptidase, SppA G4O42_13815 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G4O42_13820 ENOG4105EFZ amidohydrolase G4O42_13825 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G4O42_13835 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) G4O42_13860 ENOG4105U5Y Transcriptional regulator G4O42_13870 ENOG4105BZU Histidine kinase G4O42_13880 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G4O42_13885 ENOG4105C26 Dehydrogenase G4O42_13935 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G4O42_13950 ENOG4108Z0Z intracellular protease Pfpi family G4O42_13970 ENOG4108NGU Transcriptional regulator G4O42_13985 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G4O42_13995 ENOG4105F1V Acetoin utilization protein G4O42_14000 ENOG4105W87 Cbs domain G4O42_14005 ENOG4105DGU Histone deacetylase G4O42_14010 ENOG4105ER2 Ompa motb domain protein G4O42_14015 ENOG4107R0U MotA TolQ exbB proton channel G4O42_14020 ENOG4105ETE Transcriptional regulator (LacI family G4O42_14025 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G4O42_14045 ENOG4105DFU Cell wall formation (By similarity) G4O42_14055 ENOG4108VDD TRNA binding domain protein G4O42_14070 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ G4O42_14085 ENOG4105C6K Malic enzyme G4O42_14090 ENOG4105C8F Beta-lactamase domain protein G4O42_14095 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G4O42_14105 ENOG4108V15 phosphotransferase enzyme family G4O42_14120 ENOG4107F58 2'-5' rna ligase G4O42_14125 ENOG4105C6T cysteine synthase G4O42_14130 ENOG4107QSE Dipeptidase G4O42_14135 ENOG4105C7N Xanthine uracil vitamin C permease G4O42_14150 ENOG4105YW5 deoR family transcriptional regulator G4O42_14165 ENOG4105CBX hi0933 family G4O42_14170 ENOG4105C94 Transporter G4O42_14210 ENOG41085GJ domain protein G4O42_14215 ENOG4105C8T Leucyl-tRNA synthetase G4O42_14225 ENOG4105BZU Histidine kinase G4O42_14230 ENOG410605W Major Facilitator G4O42_14245 ENOG4105C19 ABC transporter G4O42_14250 ENOG4105EWM Histidine kinase G4O42_14260 ENOG4107R34 abc transporter permease protein G4O42_14265 ENOG4105C19 ABC transporter G4O42_14285 ENOG4105DVE abc transporter atp-binding protein G4O42_14290 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family G4O42_14300 ENOG4105N5T Radical SAM Protein G4O42_14315 ENOG4107VXM glycerophosphoryl diester phosphodiesterase G4O42_14325 ENOG4105E8V Alpha Beta Hydrolase Fold protein G4O42_14330 ENOG4108Z0R Transferase G4O42_14335 ENOG4105C85 amino acid G4O42_14340 ENOG4105CAQ asparagine synthetase G4O42_14345 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G4O42_14350 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase G4O42_14365 ENOG4105D2X ABC transporter substrate-binding protein G4O42_14375 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component G4O42_14390 ENOG4108RMU ferritin dps family protein G4O42_14405 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) G4O42_14410 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G4O42_14415 ENOG4108V2W Carbonate dehydratase G4O42_14420 ENOG4105NRA 50s ribosomal protein l31 type b G4O42_14445 ENOG4105DTQ mandelate racemase muconate lactonizing G4O42_14450 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_14455 ENOG4108IPT Naphthoate synthase G4O42_14460 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) G4O42_14465 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) G4O42_14470 ENOG4105E4F Isochorismate synthase G4O42_14605 ENOG4105N67 Proton-coupled thiamine transporter YuaJ G4O42_14610 ENOG4105DZ6 Band 7 protein G4O42_14620 ENOG4106DF1 G4O42_14625 ENOG4108VNY MOSC domain protein G4O42_14630 ENOG4108JB8 alcohol dehydrogenase G4O42_14640 ENOG4105TRT Transcriptional regulator G4O42_14655 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G4O42_14660 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G4O42_14680 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G4O42_14690 ENOG4105EE0 oxidoreductase G4O42_14695 ENOG4108Z0Z intracellular protease Pfpi family G4O42_14700 ENOG4105C8Q Methyl-accepting chemotaxis G4O42_14705 ENOG4105C8Q Methyl-accepting chemotaxis G4O42_14710 ENOG4105C8Q Methyl-accepting chemotaxis G4O42_14715 ENOG4105C8Q Methyl-accepting chemotaxis G4O42_14730 ENOG4105EA8 2-Nitropropane dioxygenase G4O42_14735 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme G4O42_14745 ENOG4105C37 (CBS) domain G4O42_14760 ENOG4107PBV potassium channel G4O42_14765 ENOG4107PBV potassium channel G4O42_14780 ENOG4107QYV phosphohexose isomerase G4O42_14790 ENOG4105CHJ isochorismatase hydrolase G4O42_14800 ENOG4107QW4 alcohol dehydrogenase G4O42_14805 ENOG4105WG9 Conserved Protein G4O42_14815 ENOG4105CHM Aminotransferase G4O42_14820 ENOG4108ZB6 transcriptional regulator AsnC family G4O42_14825 ENOG4108MUZ hydrolase G4O42_14835 ENOG4105C87 Aminotransferase class I and II G4O42_14840 ENOG4108HGU Histidine kinase G4O42_14845 ENOG4105Y38 Kinase-associated protein B G4O42_14860 ENOG4105BZ4 penicillin-binding protein G4O42_14865 ENOG4105KIR Thiol-disulfide oxidoreductase dcc G4O42_14880 ENOG4108MRH transcriptional regulatory protein G4O42_14885 ENOG4105DIH basic membrane G4O42_14890 ENOG4108JQ9 ABC transporter G4O42_14895 ENOG4105UIB (ABC) transporter G4O42_14910 ENOG4105D65 subunit l G4O42_14915 ENOG4105HC0 Na H antiporter G4O42_14920 ENOG4108ZE9 Monovalent cation H antiporter subunit C G4O42_14925 ENOG4108JPZ Monovalent cation H antiporter subunit D G4O42_14930 ENOG4105SC1 monovalent cation H antiporter subunit E G4O42_14940 ENOG4105KJM monovalent cation h antiporter subunit g G4O42_14945 ENOG4105KA0 thioesterase Superfamily protein G4O42_14955 ENOG4105BZU Histidine kinase G4O42_14985 ENOG4105D58 Diguanylate phosphodiesterase G4O42_14990 ENOG4105DAP Nicotinate phosphoribosyltransferase G4O42_15015 ENOG4105C02 permease G4O42_15030 ENOG410904N short-chain dehydrogenase reductase G4O42_15065 ENOG4108K8K Transcriptional regulator G4O42_15070 ENOG4105DCF alanine dehydrogenase G4O42_15080 ENOG4105WQT MbtH domain protein G4O42_15085 ENOG4105CEY Amp-dependent synthetase and ligase G4O42_15090 ENOG4105WQI isochorismatase G4O42_15095 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G4O42_15100 ENOG4105E4F Isochorismate synthase G4O42_15105 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G4O42_15110 ENOG4105NIV Esterase G4O42_15130 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G4O42_15140 ENOG41069ER domain protein G4O42_15155 ENOG4105CEP NADH dehydrogenase G4O42_15165 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) G4O42_15180 ENOG4105CJ1 ABC, transporter G4O42_15200 ENOG4105D9U N-acetyltransferase G4O42_15205 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G4O42_15210 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G4O42_15215 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G4O42_15225 ENOG4105ZKE UPF0349 protein G4O42_15240 ENOG41083MR nifu domain-containing protein G4O42_15245 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein G4O42_15250 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G4O42_15255 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G4O42_15260 ENOG4105D6E homoserine dehydrogenase G4O42_15270 ENOG4108W5N phosphatidylglycerophosphatase a G4O42_15275 ENOG4105D4U had-superfamily hydrolase, subfamily iia G4O42_15285 ENOG4105MMD transcriptional regulator G4O42_15290 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G4O42_15295 ENOG4105FAA peptidase M23 G4O42_15300 ENOG4108YTE sporulation protein YunB G4O42_15305 ENOG4107R8B 5'-nucleotidase G4O42_15315 ENOG4105I3N Conserved Protein G4O42_15325 ENOG4105CD3 dihydroorotase G4O42_15330 ENOG4105G9B Transcriptional regulator G4O42_15355 ENOG4105C5R Aminotransferase G4O42_15365 ENOG4108K8S endonuclease I G4O42_15370 ENOG4108IJ9 (ABC) transporter G4O42_15375 ENOG4105FDP GntR family transcriptional regulator G4O42_15380 ENOG4108KPW sugar kinase G4O42_15385 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G4O42_15390 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G4O42_15395 ENOG4105XN3 extracellular solute-binding protein family 1 G4O42_15400 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine G4O42_15405 ENOG4108Z6Z Transcriptional regulator G4O42_15430 ENOG4105PKS Excinuclease abc c subunit domain protein G4O42_15435 ENOG4107VFR oxidoreductase G4O42_15455 ENOG41083Q9 chitosanase G4O42_15460 ENOG4105DIW FeS assembly protein SUFB G4O42_15465 ENOG4108UNV SUF system FeS assembly protein, NifU family G4O42_15470 ENOG4105C9B Cysteine desulfurase G4O42_15475 ENOG4105JRK feS assembly protein SufD G4O42_15480 ENOG4105C3K feS assembly ATPase SufC G4O42_15495 ENOG4105D01 (LipO)protein G4O42_15500 ENOG4108UMI ABC transporter, permease G4O42_15505 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G4O42_15530 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G4O42_15535 ENOG41080E8 Transcriptional regulator, Spx MgsR family G4O42_15540 ENOG4105C1G acyl-Coa dehydrogenase G4O42_15545 ENOG4105CHU acetyl-coa acetyltransferase G4O42_15575 ENOG41067TZ transcriptional regulator, MarR family G4O42_15580 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4O42_15585 ENOG4105MDS 4-oxalocrotonate tautomerase G4O42_15595 ENOG4105EGI Transcriptional regulator G4O42_15605 ENOG4105C5Q Transcriptional regulator G4O42_15625 ENOG4105E0A ABC, transporter G4O42_15640 ENOG4105E1F short-chain dehydrogenase reductase G4O42_15645 ENOG4105HUF DNA protection during starvation protein G4O42_15650 ENOG4105C0H protease G4O42_15660 ENOG4105F3H Histidine kinase G4O42_15670 ENOG41067SE Tetr family transcriptional regulator G4O42_15675 ENOG4105C9Q fumarate hydratase class II G4O42_15700 ENOG4105WH1 Two component transcriptional regulator luxr family G4O42_15705 ENOG4105ENE Histidine kinase G4O42_15720 ENOG41087YS Phage shock protein A G4O42_15735 ENOG4108WBT adenosyltransferase G4O42_15740 ENOG4105E0A ABC, transporter G4O42_15745 ENOG4105EHG Permease protein G4O42_15750 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G4O42_15755 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G4O42_15760 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein G4O42_15770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4O42_15780 ENOG4106DF4 Sigma-70, region 4 G4O42_15790 ENOG4105F0F Oxalate decarboxylase G4O42_15800 ENOG4105E0A ABC, transporter G4O42_15805 ENOG4105EHG Permease protein G4O42_15810 ENOG4105DQ5 transport system permease protein G4O42_15820 ENOG4105D5Q Arginine ornithine antiporter G4O42_15830 ENOG4107K5X Membrane-bound metal-dependent hydrolase G4O42_15835 ENOG4107QZ2 Sulfatase G4O42_15840 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family G4O42_15845 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G4O42_15850 ENOG4105E0C molybdate abc transporter G4O42_15855 ENOG4105WH1 Two component transcriptional regulator luxr family G4O42_15860 ENOG4105BZU Histidine kinase G4O42_15865 ENOG4105CJ1 ABC, transporter G4O42_15875 ENOG4108KYE ABC-2 type transporter G4O42_15890 ENOG4105EEQ Na H antiporter G4O42_15895 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G4O42_15900 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4O42_15905 ENOG4105EEM helicase G4O42_15910 ENOG4105EN6 Membrane G4O42_15925 ENOG4107ZQN disulfide bond G4O42_15930 ENOG4105C59 p-type ATPase G4O42_15935 ENOG4105C59 p-type ATPase G4O42_15940 ENOG410681U heavy metal transport detoxification protein G4O42_15945 ENOG4105VPX protein, conserved in bacteria G4O42_15950 ENOG4105D9R oxidoreductase G4O42_15955 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G4O42_15970 ENOG4105DEN Luciferase family G4O42_15975 ENOG4105CDA abc transporter atp-binding protein G4O42_16000 ENOG4108XSB acetyltransferase, (GNAT) family G4O42_16005 ENOG4108KSA LysR family transcriptional regulator G4O42_16010 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G4O42_16045 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G4O42_16050 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G4O42_16060 ENOG4105XZU Preprotein translocase, subunit SecG G4O42_16080 ENOG4105KVH Transcriptional regulator G4O42_16105 ENOG4105DA5 (ABC) transporter G4O42_16110 ENOG4105R40 Glycine betaine carnitine choline G4O42_16115 ENOG4108HQR Glycine betaine G4O42_16120 ENOG4105E90 ABC transporter G4O42_16125 ENOG4108IJ8 ABC transporter G4O42_16130 ENOG4107HG4 Transcriptional regulator G4O42_16135 ENOG4105R40 Glycine betaine carnitine choline G4O42_16140 ENOG4108HQR Glycine betaine G4O42_16145 ENOG4105E90 ABC transporter G4O42_16150 ENOG4108IJ8 ABC transporter G4O42_16155 ENOG4107HG4 Transcriptional regulator G4O42_16160 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G4O42_16170 ENOG4105T65 Membrane-associated protein G4O42_16175 ENOG4108W0I acetyltransferase G4O42_16190 ENOG4105FJR Lmbe family G4O42_16210 ENOG4108IAJ Nad-dependent epimerase dehydratase G4O42_16215 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4O42_16220 ENOG4107QQG Dehydrogenase G4O42_16225 ENOG4105IIU Aminopeptidase G4O42_16230 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G4O42_16235 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G4O42_16240 ENOG4105CP7 Triose-phosphate isomerase G4O42_16245 ENOG4105BZA Phosphoglycerate kinase G4O42_16250 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4O42_16265 ENOG4105CMD Transcriptional regulator, GntR family G4O42_16270 ENOG4105DEN Luciferase family G4O42_16280 ENOG4105GZI Transcriptional regulator G4O42_16285 ENOG4107RT3 EamA-like transporter family G4O42_16305 ENOG410667J hydrolase G4O42_16310 ENOG4106KNT transcriptional regulator G4O42_16315 ENOG4105CMG Carbohydrate kinase G4O42_16320 ENOG4105C6Z Gluconate G4O42_16345 ENOG4107QR9 Iron-sulfur cluster binding protein G4O42_16350 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4O42_16355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4O42_16360 ENOG4105JXH GntR family transcriptional regulator G4O42_16365 ENOG4105DAA L-lactate G4O42_16370 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4O42_16380 ENOG4108ZPC Polysaccharide pyruvyl transferase G4O42_16385 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4O42_16390 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family G4O42_16395 ENOG4105D3Q Sugar transferase G4O42_16405 ENOG4105K64 Glycosyl transferase, family 2 G4O42_16415 ENOG4107QRS glycosyltransferase group 2 family protein G4O42_16420 ENOG41068W6 Capsular polysaccharide biosynthesis protein G4O42_16425 ENOG4108KMV Glycosyl transferase (Group 1 G4O42_16430 ENOG4105K64 Glycosyl transferase, family 2 G4O42_16435 ENOG4108PQP glycosyl transferase group 1 G4O42_16445 ENOG4108QV3 biosynthesis protein G4O42_16450 ENOG4105HTX biosynthesis protein G4O42_16460 ENOG4105EBR Carboxylesterase G4O42_16465 ENOG4105NAE bifunctional deaminase-reductase domain protein G4O42_16475 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 G4O42_16480 ENOG4105PY6 Phenolic acid decarboxylase G4O42_16525 ENOG4108HKT sucrose-6-phosphate hydrolase G4O42_16530 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G4O42_16535 ENOG4105ETE Transcriptional regulator (LacI family G4O42_16540 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G4O42_16545 ENOG4107URF beta-phospho-glucomutase G4O42_16550 ENOG4105CG3 alpha amylase, catalytic region G4O42_16565 ENOG4105EG2 ABC transporter, permease G4O42_16570 ENOG4105D56 permease protein G4O42_16575 ENOG4107FKK extracellular solute-binding protein family 1 G4O42_16580 ENOG4108IUK alpha amylase, catalytic G4O42_16585 ENOG4105FKQ transcriptional regulator G4O42_16590 ENOG4108URH decarboxylase G4O42_16595 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain G4O42_16600 ENOG4105CHH sulfate transporter G4O42_16605 ENOG4108V2W Carbonate dehydratase G4O42_16610 ENOG4105C5I Dehydrogenase G4O42_16615 ENOG4105GGE ribonuclease G4O42_16620 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G4O42_16625 ENOG4105KRI phosphocarrier protein (HPr G4O42_16630 ENOG4105CIE May be required for sporulation (By similarity) G4O42_16635 ENOG4105CHW UPF0052 protein G4O42_16640 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G4O42_16645 ENOG4108Z4K mutator MutT protein G4O42_16650 ENOG4105C3M thioredoxin reductase G4O42_16665 ENOG4105BZU Histidine kinase G4O42_16670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4O42_16675 ENOG4105BZ1 (ABC) transporter G4O42_16680 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G4O42_16685 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G4O42_16690 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G4O42_16695 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G4O42_16700 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G4O42_16705 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G4O42_16710 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G4O42_16715 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) G4O42_16725 ENOG4108S4C acetyltransferase G4O42_16730 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G4O42_16740 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) G4O42_16745 ENOG4105CE4 GlcNAc 6-P deacetylase G4O42_16750 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G4O42_16760 ENOG4105J7D transcriptional regulator G4O42_16765 ENOG41088CQ domain protein G4O42_16770 ENOG41086DT Membrane protein of unknown function G4O42_16775 ENOG41067S9 phage shock protein C, PspC G4O42_16780 ENOG4108PY7 G4O42_16795 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G4O42_16800 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G4O42_16815 ENOG4105MKU Transcriptional regulator G4O42_16845 ENOG4105CN1 protease G4O42_16850 ENOG4108M26 parallel beta-helix repeat protein G4O42_16855 ENOG4105CRP Part of the ABC transporter FtsEX involved in G4O42_16860 ENOG4105CAK Cell division ATP-binding protein ftsE G4O42_16880 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving G4O42_16885 ENOG4105MS2 ribosomal subunit Interface protein G4O42_16900 ENOG4105MQ3 flagellar protein FliS G4O42_16905 ENOG4107RT6 flagellar hook-associated G4O42_16910 ENOG4105I03 Flagellin G4O42_16915 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) G4O42_16920 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) G4O42_16930 ENOG4105DTJ flagellar hook-associated protein G4O42_16935 ENOG4105E1Q flagellar hook-associated protein G4O42_16950 ENOG4105RU3 G4O42_16955 ENOG41081UC Inherit from COG: Competence protein G4O42_16975 ENOG4105WH1 Two component transcriptional regulator luxr family G4O42_16980 ENOG4105BZU Histidine kinase G4O42_16985 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G4O42_16990 ENOG4108KGH TRANSCRIPTIONal G4O42_16995 ENOG4105ESV Glycosyl transferase, family 4 G4O42_17000 ENOG4107EF8 Glycosyl transferase (Group 1 G4O42_17015 ENOG4105QZI O-Antigen Polymerase G4O42_17020 ENOG4105C6Y Udp-glucose 6-dehydrogenase G4O42_17025 ENOG4107RA4 Glycosyl transferase (Group 1 G4O42_17030 ENOG4105PSV Polysaccharide Biosynthesis Protein G4O42_17035 ENOG4105D3Q Sugar transferase G4O42_17040 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4O42_17045 ENOG4105JFG SpoIID LytB domain protein G4O42_17060 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G4O42_17065 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4O42_17070 ENOG4105EY8 ABC transporter G4O42_17080 ENOG4107SJB teichoic acid biosynthesis G4O42_17090 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase G4O42_17100 ENOG4107RZX Teichoic acid biosynthesis protein G4O42_17110 ENOG4105DG6 mannose-6-phosphate isomerase G4O42_17125 ENOG4108NHD germination protein G4O42_17130 ENOG4107R8N Glycosyl transferase, family 2 G4O42_17135 ENOG4105C54 Major Facilitator superfamily G4O42_17140 ENOG4108KGH TRANSCRIPTIONal G4O42_17145 ENOG4105J7I hydrolase G4O42_17150 ENOG4106UBQ G4O42_17155 ENOG4105K4H Nlp p60 protein G4O42_17165 ENOG4105PNM synthesis protein G4O42_17175 ENOG4105N98 Capsule biosynthesis protein capB G4O42_17180 ENOG4105E1K spore germination protein G4O42_17195 ENOG4105ETE Transcriptional regulator (LacI family G4O42_17200 ENOG4108RVA ribokinase G4O42_17205 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) G4O42_17210 ENOG4105C2J ABC transporter G4O42_17215 ENOG4105CNN ABC, transporter G4O42_17220 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4O42_17230 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G4O42_17235 ENOG4107FQX Alpha-acetolactate decarboxylase G4O42_17245 ENOG4107RSM transcriptional regulator G4O42_17260 ENOG4106UIA G4O42_17275 ENOG4107XC4 flavin reductase domain protein, FMN-binding G4O42_17285 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G4O42_17295 ENOG4105CAH Chromate G4O42_17300 ENOG4105FGV Chromate G4O42_17310 ENOG4108WS4 fmn reductase G4O42_17315 ENOG4107V2S Transcriptional regulator G4O42_17320 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) G4O42_17355 ENOG4108XI2 Domain of unknown function (DUF1963) G4O42_17360 ENOG4105C6Y Udp-glucose 6-dehydrogenase G4O42_17365 ENOG4108RB3 Capsular polysaccharide biosynthesis protein G4O42_17370 ENOG4107YJ4 chain length determinant protein G4O42_17375 ENOG4105HTX biosynthesis protein G4O42_17385 ENOG4105KBK Zinc finger, swim domain protein G4O42_17390 ENOG4105C0D helicase G4O42_17395 ENOG410667J hydrolase G4O42_17400 ENOG4105E98 transcriptional regulator DeoR family G4O42_17405 ENOG4105Z8H single-stranded DNA-binding protein G4O42_17420 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G4O42_17425 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G4O42_17435 ENOG4105CGA flagellar basal-body rod protein FlgG G4O42_17445 ENOG4105DFF Rod shape-determining protein mreb G4O42_17450 ENOG4105MT0 Sporulation transcriptional regulator spoiiid G4O42_17455 ENOG4107MII Sugar-specific transcriptional regulator TrmB G4O42_17460 ENOG4105CZM Major Facilitator G4O42_17465 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G4O42_17470 ENOG41080V3 Major Facilitator superfamily G4O42_17475 ENOG4105D3W isochorismatase G4O42_17480 ENOG4105BZU Histidine kinase G4O42_17490 ENOG4105CNI cell division protein FtsW G4O42_17495 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G4O42_17505 ENOG4105FRN stage II sporulation protein G4O42_17510 ENOG4107TCE N-acetyltransferase G4O42_17525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G4O42_17530 ENOG4106BRK G4O42_17535 ENOG4107T94 Endo-14-beta-xylanase G4O42_17545 ENOG4108Z40 Transcriptional regulator G4O42_17550 ENOG4105CQM Urea amidohydrolase subunit alpha G4O42_17555 ENOG4105KI2 Urea amidohydrolase subunit beta G4O42_17560 ENOG4108YZ9 Urea amidohydrolase subunit gamma G4O42_17580 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G4O42_17585 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G4O42_17590 ENOG4108TF4 von Willebrand factor, type A G4O42_17605 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G4O42_17615 ENOG4106778 Protein of unknown function (DUF1146) G4O42_17625 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G4O42_17630 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G4O42_17635 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G4O42_17640 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G4O42_17645 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) G4O42_17660 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) G4O42_17670 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G4O42_17675 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G4O42_17680 ENOG4108UIC UPF0340 protein G4O42_17685 ENOG4108YZG isomerase G4O42_17690 ENOG4107WAU Protein tyrosine phosphatase G4O42_17695 ENOG410815N Probably functions as a manganese efflux pump (By similarity) G4O42_17700 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G4O42_17710 ENOG4108ZXQ stage ii sporulation protein r G4O42_17725 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G4O42_17730 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G4O42_17735 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase G4O42_17745 ENOG4107TT2 Auxin Efflux Carrier G4O42_17750 ENOG4105C6K Malic enzyme G4O42_17755 ENOG4107104 thymidine kinase G4O42_17765 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G4O42_17770 ENOG4105CBT Fructose-1,6-bisphosphatase G4O42_17775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G4O42_17785 ENOG4105D2N Aldolase G4O42_17790 ENOG410812K response regulator receiver protein G4O42_17800 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G4O42_17810 ENOG4105DF6 Fe-S oxidoreductase G4O42_17820 ENOG4105E5J UV damage endonuclease G4O42_17830 ENOG4105BZ1 (ABC) transporter G4O42_17835 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G4O42_17850 ENOG4105R3A Nitrate reductase G4O42_17855 ENOG4108IUE nitrate reductase beta subunit G4O42_17875 ENOG4107V6Q Cyclic nucleotide-binding domain G4O42_17885 ENOG4105C75 arginyL-tRNA synthetase G4O42_17890 ENOG410684U Domain of unknown function (DUF1934) G4O42_17910 ENOG4107JM4 Tetratricopeptide repeat G4O42_17920 ENOG4105CYW agmatinase G4O42_17925 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G4O42_17930 ENOG4105BZ4 penicillin-binding protein G4O42_17940 ENOG4108XFG YwhD family G4O42_17945 ENOG4108Z4T Peptidase M50 G4O42_17950 ENOG41069HH 4-oxalocrotonate tautomerase G4O42_17955 ENOG41067TZ transcriptional regulator, MarR family G4O42_17960 ENOG4105CUB amino acid G4O42_17970 ENOG4105DCI Phosphohydrolase G4O42_17980 ENOG4108VCI transcription factor, rsfa family G4O42_17985 ENOG4105K7K Transcriptional regulator G4O42_17995 ENOG4105CJ1 ABC, transporter G4O42_18000 ENOG4108TU7 Inherit from COG: (ABC) transporter G4O42_18025 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) G4O42_18030 ENOG4105DUM transcriptional regulator, lysR family G4O42_18035 ENOG4105HMI Membrane G4O42_18040 ENOG4108IJ2 phosphate acetyltransferase G4O42_18045 ENOG4107JTW chlorite dismutase G4O42_18055 ENOG4105CHM Aminotransferase G4O42_18085 ENOG4105FCW Major Facilitator superfamily G4O42_18090 ENOG4105C2C drug resistance transporter, Bcr CflA G4O42_18105 ENOG4105C26 Dehydrogenase G4O42_18110 ENOG4105D82 Glutamate dehydrogenase G4O42_18120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4O42_18140 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase G4O42_18145 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G4O42_18150 ENOG4105C1B dTDP-glucose 4-6-dehydratase G4O42_18155 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G4O42_18160 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG G4O42_18165 ENOG4107TY6 Acylneuraminate cytidylyltransferase G4O42_18175 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD G4O42_18180 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4O42_18215 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G4O42_18220 ENOG4108RJ9 Glycosyl transferase, family 2 G4O42_18240 ENOG4105DWF phosphomethylpyrimidine kinase G4O42_18255 ENOG4105C5Y PTS System G4O42_18270 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin G4O42_18275 ENOG4105DEN Luciferase family G4O42_18280 ENOG4108DBC nitroreductase G4O42_18290 ENOG4105I4A GCN5-related N-acetyltransferase G4O42_18310 ENOG4105BZ9 Cytochrome C oxidase, subunit I G4O42_18315 ENOG4105E2S oxidase) subunit II G4O42_18320 ENOG4107BMA Transglycosylase associated protein G4O42_18330 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G4O42_18335 ENOG4105WH5 Teichoic acid glycosylation protein G4O42_18360 ENOG4107ZXU DSBA oxidoreductase G4O42_18365 ENOG4105DBE peroxidase G4O42_18370 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G4O42_18375 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase G4O42_18380 ENOG4105CMU LysR family (Transcriptional regulator G4O42_18385 ENOG4105VAW lrga family G4O42_18390 ENOG41067MG lrgb family G4O42_18400 ENOG4107TXC Transcriptional regulator G4O42_18410 ENOG4105DR4 Methyltransferase G4O42_18420 ENOG4105CK1 PTS System G4O42_18425 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin G4O42_18430 ENOG4105X1N Glycosyl transferase family 8 G4O42_18440 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase G4O42_18450 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) G4O42_18455 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein G4O42_18460 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) G4O42_18465 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD G4O42_18470 ENOG4105CM2 brancheD-chain amino acid aminotransferase G4O42_18475 ENOG4105F8D glycoside hydrolase family 4 G4O42_18480 ENOG4105VCP PTS System G4O42_18485 ENOG4105CK1 PTS System G4O42_18490 ENOG4105VZJ PTS System G4O42_18495 ENOG4105EMD TRANSCRIPTIONal G4O42_18505 ENOG4105DQ5 transport system permease protein G4O42_18510 ENOG4105EHG Permease protein G4O42_18520 ENOG41082YX Transcriptional regulator, arsr family G4O42_18525 ENOG4107R5R arsenical pump membrane protein G4O42_18530 ENOG4105VZJ PTS System G4O42_18535 ENOG4105VCP PTS System G4O42_18540 ENOG4105CK1 PTS System G4O42_18545 ENOG4105CS2 ec 3.2.1.21 G4O42_18555 ENOG4105DG6 mannose-6-phosphate isomerase G4O42_18565 ENOG4105CH6 catalase G4O42_18570 ENOG4107QHE Choloylglycine hydrolase G4O42_18575 ENOG4105ETS cytosine purines uracil thiamine allantoin G4O42_18595 ENOG4105DY9 regulatoR G4O42_18615 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G4O42_18620 ENOG4108JJ8 (ABC) transporter G4O42_18625 ENOG4108JJ9 ABC, transporter G4O42_18630 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G4O42_18635 ENOG4105C4M (Ubiquinol oxidase) subunit I G4O42_18640 ENOG4105D2K citrate carrier protein G4O42_18645 ENOG4107BJW polysaccharide deacetylase G4O42_18660 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) G4O42_18670 ENOG4105CMR udp-glucose 4-epimerase G4O42_18675 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) G4O42_18690 ENOG4105DHI Methyltransferase G4O42_18710 ENOG4105CH6 catalase G4O42_18715 ENOG4105D4T Citrate transporter G4O42_18730 ENOG4105DEU major facilitator superfamily G4O42_18735 ENOG4105C1J atp-dependent rna helicase G4O42_18740 ENOG4108NR7 pectate lyase G4O42_18750 ENOG4107YZX Universal stress protein G4O42_18805 ENOG4106Z5D Glycoside Hydrolase Family 43 G4O42_18815 ENOG4105C84 Histidine ammonia-lyase G4O42_18820 ENOG4105CGP Urocanate hydratase G4O42_18825 ENOG4105CI2 imidazolone-5-propionate hydrolase G4O42_18830 ENOG4107W25 arginase agmatinase formiminoglutamase G4O42_18840 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) G4O42_18845 ENOG4105D9N nucleoside G4O42_18850 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G4O42_18855 ENOG4107RHR regulatoR G4O42_18860 ENOG410667J hydrolase G4O42_18890 ENOG4108V5C ABC transporter G4O42_18925 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4O42_18950 ENOG4105WZ4 isomerase G4O42_18955 ENOG4105F0H myo-inositol catabolism protein G4O42_18960 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G4O42_18970 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) G4O42_18980 ENOG4105EDK PfkB domain protein G4O42_18990 ENOG4105C26 Dehydrogenase G4O42_19000 ENOG4105CPC Aldo Keto reductase G4O42_19005 ENOG4107QNK )-transporter G4O42_19010 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G4O42_19020 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G4O42_19025 ENOG4108S01 response regulator G4O42_19030 ENOG4108ZGX Histidine kinase G4O42_19035 ENOG4105ECK Fatty Acid Desaturase G4O42_19040 ENOG4105ST3 Transcriptional regulator G4O42_19045 ENOG4105C26 Dehydrogenase G4O42_19050 ENOG4108ITS PQQ enzyme repeat G4O42_19060 ENOG4105WAB arsR family transcriptional regulator G4O42_19065 ENOG4105F27 Major Facilitator G4O42_19070 ENOG41085PJ rdd domain containing protein G4O42_19080 ENOG4105D3R alkyl hydroperoxide reductase G4O42_19085 ENOG4108JU3 Alkyl hydroperoxide reductase G4O42_19090 ENOG4107R3N Filamentation induced by cAMP protein fic G4O42_19095 ENOG4105C85 amino acid G4O42_19100 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 G4O42_19105 ENOG4108XHQ (2Fe-2S)-binding domain protein G4O42_19125 ENOG4105XRQ Xanthine dehydrogenase accessory factor G4O42_19160 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G4O42_19180 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) G4O42_19185 ENOG4105CPC Aldo Keto reductase G4O42_19190 ENOG4105WQG acetyltransferase G4O42_19200 ENOG41066UZ arginase EC 3.5.3.1 G4O42_19205 ENOG4108IQI permease G4O42_19210 ENOG4105C8Y Acetylornithine aminotransferase G4O42_19220 ENOG41082BM Transcriptional regulator, arsr family G4O42_19225 ENOG4108JUB Transcriptional regulator G4O42_19235 ENOG4105C5H ABC transporter G4O42_19250 ENOG4105D06 uba thif-type nad fad binding protein G4O42_19255 ENOG41062D9 Histidine kinase G4O42_19260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4O42_19265 ENOG4105C0H protease G4O42_19270 ENOG4105Q2H domain protein G4O42_19285 ENOG4105BZU Histidine kinase G4O42_19290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4O42_19315 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G4O42_19320 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase G4O42_19325 ENOG4105CDU Replicative dna helicase G4O42_19345 ENOG4105EDW glycosyl transferase, family 39 G4O42_19350 ENOG4107QPH glycogen) synthase G4O42_19360 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR G4O42_19365 ENOG4105CPK Glycosyl transferase (Group 1 G4O42_19385 ENOG4105BZR domain protein G4O42_19390 ENOG4108XMW Membrane G4O42_19405 ENOG4105KVH Transcriptional regulator G4O42_19410 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase G4O42_19415 ENOG4108UZ3 Transporter G4O42_19420 ENOG4105EDQ levansucrase EC 2.4.1.10 G4O42_19425 ENOG4108HKT sucrose-6-phosphate hydrolase G4O42_19450 ENOG4108TVJ Nitroreductase G4O42_19455 ENOG4105FS7 Transcriptional regulator G4O42_19465 ENOG4108U05 Transcriptional regulator G4O42_19470 ENOG41082BV acetyltransferase G4O42_19480 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G4O42_19485 ENOG4105CMU LysR family (Transcriptional regulator G4O42_19490 ENOG4105DTD Dehydrogenase G4O42_19500 ENOG4107Y9U Membrane G4O42_19505 ENOG4105C7Z Conserved Protein G4O42_19530 ENOG4105C7Z Conserved Protein G4O42_19535 ENOG4107FCW Abortive infection protein G4O42_19545 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase G4O42_19555 ENOG4105CGK Exodeoxyribonuclease III G4O42_19560 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4O42_19570 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G4O42_19575 ENOG4108UUM single-stranded DNA-binding protein G4O42_19580 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) G4O42_19585 ENOG4105C3G gtp-binding protein G4O42_19590 ENOG4108J2R molybdopterin oxidoreductase G4O42_19595 ENOG4105VDK protein, conserved in bacteria G4O42_19610 ENOG4108ZDA Sporulation protein YyaC G4O42_19615 ENOG4105FA0 parb-like partition protein G4O42_19620 ENOG4107QJE Chromosome Partitioning Protein G4O42_19635 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G4O42_19640 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G4O42_19655 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)