locus-tag class description CDO84_00040 ENOG4108JPW Aminotransferase CDO84_00050 ENOG4105CPQ Dehydrogenase CDO84_00055 ENOG4105CHH sulfate transporter CDO84_00065 ENOG4108SA1 esterase CDO84_00085 ENOG410874W AraC family transcriptional regulator CDO84_00090 ENOG4105EHZ conserved protein UCP016719 CDO84_00095 ENOG4105D17 glycoside hydrolase, family 3 domain protein CDO84_00115 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CDO84_00125 ENOG4105EWC Purine nucleoside phosphorylase CDO84_00155 ENOG4105EMN RNA polymerase sigma factor CDO84_00165 ENOG4105C8B TIGR00159 family CDO84_00170 ENOG4107U5W ybbr family CDO84_00175 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CDO84_00180 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CDO84_00185 ENOG4105D03 DNA-3-methyladenine glycosylase II CDO84_00195 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CDO84_00200 ENOG4108TWJ NADH dehydrogenase subunit 5 CDO84_00220 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CDO84_00225 ENOG4105WAB arsR family transcriptional regulator CDO84_00230 ENOG4108RWP Major Facilitator Superfamily protein CDO84_00265 ENOG4105G0J serine threonine protein kinase CDO84_00275 ENOG4106K80 CDO84_00285 ENOG4106DDH Sporulation-specific SASP protein CDO84_00295 ENOG4108HWY Beta-lactamase CDO84_00300 ENOG4107E6A Cytochrome p-450 CDO84_00310 ENOG4107QTZ amino acid CDO84_00320 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CDO84_00325 ENOG4105CXY transporter CDO84_00340 ENOG410645S MarR family Transcriptional regulator CDO84_00345 ENOG4105DCM major facilitator superfamily CDO84_00355 ENOG410631K Membrane CDO84_00360 ENOG4106AXJ AraC family transcriptional regulator CDO84_00365 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CDO84_00370 ENOG4108TCS Glutamyl endopeptidase CDO84_00380 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CDO84_00385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CDO84_00390 ENOG4107ZTW SNARE associated Golgi CDO84_00415 ENOG4105C72 UPF0176 protein CDO84_00425 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane CDO84_00430 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CDO84_00435 ENOG4108X79 transcriptional regulator CDO84_00445 ENOG4105CM2 brancheD-chain amino acid aminotransferase CDO84_00450 ENOG4108IQI permease CDO84_00455 ENOG4108J5H Homocysteine s-methyltransferase CDO84_00465 ENOG4105CSV Glutaminase CDO84_00480 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase CDO84_00485 ENOG4105C26 Dehydrogenase CDO84_00490 ENOG4105DJB Major Facilitator Superfamily CDO84_00495 ENOG4105EQX glucarate dehydratase CDO84_00500 ENOG41073TP transcriptional regulator CDO84_00505 ENOG4105CTX dehydratase CDO84_00520 ENOG4106UX7 integral membrane protein CDO84_00525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CDO84_00565 ENOG4105DGI Alkaline phosphatase CDO84_00570 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CDO84_00575 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CDO84_00580 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CDO84_00585 ENOG4107EPV Aminotransferase class V CDO84_00590 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDO84_00595 ENOG4105J7D transcriptional regulator CDO84_00600 ENOG4107RB3 L-asparaginase CDO84_00605 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold CDO84_00615 ENOG41060AI SEC-C motif CDO84_00625 ENOG4107Y7X LytTR CDO84_00630 ENOG4108IUW ABC transporter CDO84_00635 ENOG4108SDH ABC, transporter CDO84_00640 ENOG4107SET aldo keto reductase CDO84_00675 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CDO84_00685 ENOG4105DSE periplasmic solute binding protein CDO84_00690 ENOG4105DIK (ABC) transporter CDO84_00700 ENOG4105DEN Luciferase family CDO84_00705 ENOG4108N0M stress protein CDO84_00710 ENOG4106FN3 tellurium resistance protein CDO84_00715 ENOG4106FN3 tellurium resistance protein CDO84_00720 ENOG4107TS3 membrane protein, TerC CDO84_00725 ENOG4108TTB tellurium resistance protein CDO84_00735 ENOG41079KZ Major Facilitator Superfamily CDO84_00740 ENOG4107XZQ multidrug resistance protein CDO84_00745 ENOG4108A65 Transcriptional regulator CDO84_00750 ENOG4108IJ7 Glycine betaine CDO84_00755 ENOG4107SQ8 Glycine betaine CDO84_00785 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CDO84_00820 ENOG4105EIG urea carboxylase-associated protein 1 CDO84_00825 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CDO84_00830 ENOG4105I1F Resistance protein CDO84_00835 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CDO84_00840 ENOG41089UC methyltransferase, type 11 CDO84_00845 ENOG4105C5Q Transcriptional regulator CDO84_00850 ENOG4105I82 acetyl xylan esterase CDO84_00855 ENOG410756H nucleotidyltransferase CDO84_00865 ENOG4105C26 Dehydrogenase CDO84_00870 ENOG4105CK7 Sodium proline symporter CDO84_00875 ENOG4107YHD transcriptional regulator CDO84_00885 ENOG4108PJD permease CDO84_00890 ENOG4105U6C Alpha beta hydrolase fold protein CDO84_00900 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CDO84_00905 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CDO84_00910 ENOG4108IFG nitrite reductase, (NAD(P)H) CDO84_00915 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CDO84_00935 ENOG4105S7A ErfK ybiS ycfS ynhG family protein CDO84_00940 ENOG4105CKI cobalamin synthesis protein CDO84_00945 ENOG4105E5Q amino acid AbC transporter CDO84_00950 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein CDO84_00955 ENOG4105HHM rdd domain containing protein CDO84_00965 ENOG4105CS2 ec 3.2.1.21 CDO84_00980 ENOG4105C8Q Methyl-accepting chemotaxis CDO84_00985 ENOG41080HJ 6-phospho 3-hexuloisomerase CDO84_00990 ENOG4108VA3 3-hexulose-6-phosphate synthase CDO84_00995 ENOG4105KVH Transcriptional regulator CDO84_01000 ENOG4105CEY Amp-dependent synthetase and ligase CDO84_01030 ENOG4105SX7 Transporter CDO84_01040 ENOG4105W8Z 4'-phosphopantetheinyl transferase CDO84_01050 ENOG4105CDA abc transporter atp-binding protein CDO84_01055 ENOG4105DRP amino acid AbC transporter CDO84_01065 ENOG4106P55 Transcriptional regulator CDO84_01070 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CDO84_01075 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CDO84_01080 ENOG41069ZX CDO84_01085 ENOG41069ZX CDO84_01095 ENOG4105DUX Transporter CDO84_01110 ENOG4105E1K spore germination protein CDO84_01130 ENOG4107WD8 ABC transporter, permease CDO84_01135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDO84_01140 ENOG4105BZU Histidine kinase CDO84_01160 ENOG4105CFH Aspartokinase CDO84_01165 ENOG4105DHS permease protein CDO84_01170 ENOG4105CM4 permease protein CDO84_01175 ENOG4108IPW abc transporter atp-binding protein CDO84_01190 ENOG4105R8C Transcriptional regulator CDO84_01195 ENOG4108DBC nitroreductase CDO84_01200 ENOG41067V3 Antibiotic biosynthesis monooxygenase CDO84_01205 ENOG4105YVS arsR family transcriptional regulator CDO84_01215 ENOG4108JPW Aminotransferase CDO84_01220 ENOG4105C26 Dehydrogenase CDO84_01230 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CDO84_01235 ENOG4105KTB nuclear export factor GLE1 CDO84_01240 ENOG4108T5E Copper resistance protein CDO84_01245 ENOG4108ZYE Transcriptional regulator CDO84_01270 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CDO84_01275 ENOG4108ZX0 Signal peptidase I CDO84_01300 ENOG4105E7W lamb ycsf family protein CDO84_01305 ENOG4105C5A transporter CDO84_01310 ENOG4105CFM UPF0317 protein CDO84_01315 ENOG4105P4J Allophanate hydrolase, subunit 1 CDO84_01325 ENOG4107258 Transcriptional regulator CDO84_01330 ENOG4105XJB lipolytic protein G-D-S-L family CDO84_01340 ENOG41061CK Antibiotic biosynthesis monooxygenase CDO84_01345 ENOG4107RVG penicillin-binding protein CDO84_01350 ENOG4107QM2 Aldo Keto reductase CDO84_01355 ENOG4105ETD TRANSCRIPTIONal CDO84_01365 ENOG4105HMZ Methyltransferase CDO84_01370 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CDO84_01385 ENOG410606W general stress protein CDO84_01395 ENOG4105VCH membrane CDO84_01405 ENOG4105C9U ATP-dependent DNA helicase RecQ CDO84_01420 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CDO84_01425 ENOG4107R8N Glycosyl transferase, family 2 CDO84_01435 ENOG4105C0X amino acid CDO84_01460 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CDO84_01470 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CDO84_01475 ENOG4105EU9 CDO84_01480 ENOG4105QVS general stress protein CDO84_01485 ENOG41082W1 Cupin 2, conserved barrel domain protein CDO84_01500 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CDO84_01505 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CDO84_01510 ENOG4108MRH transcriptional regulatory protein CDO84_01515 ENOG4107QJT sodium dicarboxylate symporter CDO84_01520 ENOG4106F5Q Membrane CDO84_01530 ENOG4105CJ1 ABC, transporter CDO84_01545 ENOG4105FDT acyl-CoA dehydrogenase CDO84_01565 ENOG4105SZ6 Thioredoxin CDO84_01570 ENOG4105CPF Cell wall formation (By similarity) CDO84_01575 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CDO84_01585 ENOG4105C1J atp-dependent rna helicase CDO84_01590 ENOG410905X membrane-flanked domain protein CDO84_01595 ENOG4105CKV Membrane CDO84_01605 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CDO84_01610 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CDO84_01615 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CDO84_01625 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CDO84_01630 ENOG4107MMM Anti-sigma-factor antagonist CDO84_01635 ENOG4105FUA antagonist CDO84_01640 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CDO84_01645 ENOG4107SGM protein serine threonine phosphatase CDO84_01650 ENOG4105WN5 stage II sporulation protein CDO84_01655 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CDO84_01665 ENOG41064BQ Phosphatase CDO84_01675 ENOG4105M5P UPF0310 protein CDO84_01680 ENOG4105RV9 Transcriptional regulator CDO84_01745 ENOG4106ANW SMI1_KNR4 CDO84_01775 ENOG4108IMY Transcriptional regulator CDO84_01800 ENOG4105CGH 5'-nucleotidase CDO84_01810 ENOG4105VEQ Cold shock protein CDO84_01820 ENOG4108MCI Transcriptional regulator, ARAC family CDO84_01825 ENOG4108UZ3 Transporter CDO84_01830 ENOG41086D8 Transcriptional regulator CDO84_01835 ENOG4107U9B transcriptional regulator CDO84_01840 ENOG4105DXI Major Facilitator superfamily CDO84_01850 ENOG4105CZ9 Domain of unknown function (DU1801) CDO84_01855 ENOG4105GIG CDO84_01860 ENOG4105T38 integral membrane protein CDO84_01865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CDO84_01870 ENOG4108ZMQ domain protein CDO84_01875 ENOG4105MJ9 esterase CDO84_01880 ENOG4107Z6X Transcriptional regulator CDO84_01890 ENOG4105EQ0 Major Facilitator superfamily CDO84_01895 ENOG4108JGH Tetr family transcriptional regulator CDO84_01905 ENOG4107R5R arsenical pump membrane protein CDO84_01915 ENOG4105Z7P Acetyltransferase (GNAT) family CDO84_01920 ENOG4108KGH TRANSCRIPTIONal CDO84_01925 ENOG4108ZJ4 polysaccharide deacetylase CDO84_01935 ENOG4105US7 Histidine kinase CDO84_01940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDO84_01945 ENOG4107Y9U Membrane CDO84_01955 ENOG4108SQ9 flavin reductase domain protein, FMN-binding CDO84_01960 ENOG4108ZHR arsR family transcriptional regulator CDO84_01965 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CDO84_01980 ENOG4105ENE Histidine kinase CDO84_01985 ENOG4108VB1 regulatoR CDO84_01990 ENOG4105EYF MMPL domain protein CDO84_01995 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CDO84_02005 ENOG4107U9B transcriptional regulator CDO84_02010 ENOG4108UMN azlc family CDO84_02015 ENOG4105KMT branched-chain amino acid CDO84_02030 ENOG4108UQV Membrane CDO84_02035 ENOG4108Z5V transcriptional regulator, merr family CDO84_02040 ENOG41076HS cation diffusion facilitator family transporter CDO84_02045 ENOG4108TVJ Nitroreductase CDO84_02050 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CDO84_02055 ENOG4108VGI doxx family CDO84_02060 ENOG4105XXY Thioredoxin CDO84_02075 ENOG410900G Protein of unknown function (DUF421) CDO84_02080 ENOG4108QY0 Membrane CDO84_02100 ENOG4105PF9 Transcriptional regulator CDO84_02110 ENOG4105WQG acetyltransferase CDO84_02120 ENOG4105C85 amino acid CDO84_02130 ENOG41062A4 Transcriptional regulator CDO84_02135 ENOG4105EYF MMPL domain protein CDO84_02140 ENOG4108TVJ Nitroreductase CDO84_02145 ENOG4105FS7 Transcriptional regulator CDO84_02150 ENOG4105C2C drug resistance transporter, Bcr CflA CDO84_02160 ENOG4105DRR Transcriptional regulator, GntR family CDO84_02165 ENOG4105VRS hydrolase family 18 CDO84_02180 ENOG4105G6Z alkaline phosphatase CDO84_02185 ENOG4108ZMX Domain of unknown function (DU1801) CDO84_02195 ENOG4108YM7 Gcn5-related n-acetyltransferase CDO84_02200 ENOG4107TVP HD domain protein CDO84_02205 ENOG41090UD (LipO)protein CDO84_02210 ENOG4105F27 Major Facilitator CDO84_02215 ENOG4105VZJ PTS System CDO84_02220 ENOG4105VCP PTS System CDO84_02225 ENOG4105CK1 PTS System CDO84_02230 ENOG4105CS2 ec 3.2.1.21 CDO84_02235 ENOG4108TZY GntR Family Transcriptional Regulator CDO84_02240 ENOG4105EVU fructokinase CDO84_02245 ENOG4105DG6 mannose-6-phosphate isomerase CDO84_02250 ENOG4105D3P Mannan endo-1,4-beta-mannosidase CDO84_02295 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CDO84_02300 ENOG4105K8N protein family UPF0079, ATPase CDO84_02305 ENOG41072GX Peptidase M22 Glycoprotease CDO84_02310 ENOG410801F ribosomal-protein-alanine acetyltransferase CDO84_02315 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CDO84_02320 ENOG4105C5H ABC transporter CDO84_02325 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CDO84_02330 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CDO84_02335 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CDO84_02340 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CDO84_02350 ENOG4108TYN CAAX amino terminal protease family protein CDO84_02355 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CDO84_02360 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CDO84_02365 ENOG4105ESF Peptidoglycan binding domain protein CDO84_02380 ENOG4105PGZ NB-ARC domain CDO84_02385 ENOG4105CPQ Dehydrogenase CDO84_02390 ENOG4105CT4 transporter CDO84_02400 ENOG41087YS Phage shock protein A CDO84_02405 ENOG4105DQX Zinc finger domain CDO84_02410 ENOG4108WV1 Pfam:DUF477 CDO84_02420 ENOG4108ZMR Ion transport 2 domain-containing protein CDO84_02425 ENOG4107QNK )-transporter CDO84_02455 ENOG4107YUH hydrolase CDO84_02465 ENOG4107STQ Multicopper oxidase CDO84_02470 ENOG4105C85 amino acid CDO84_02485 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CDO84_02515 ENOG4105C7N Xanthine uracil vitamin C permease CDO84_02540 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CDO84_02545 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CDO84_02550 ENOG4105C83 adenylosuccinate lyase CDO84_02555 ENOG4105C8V SAICAR synthetase CDO84_02560 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CDO84_02565 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CDO84_02570 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CDO84_02580 ENOG4105CXB phosphoribosylaminoimidazole synthetase CDO84_02585 ENOG4108V3E phosphoribosylglycinamide formyltransferase CDO84_02590 ENOG4105DC1 bifunctional purine biosynthesis protein purh CDO84_02595 ENOG4105C12 Phosphoribosylglycinamide synthetase CDO84_02605 ENOG4105DVH amino acid CDO84_02620 ENOG4108R5T secreted protein CDO84_02625 ENOG4105KGF protein, YerC YecD CDO84_02630 ENOG4105CBC glutamate synthase CDO84_02635 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CDO84_02640 ENOG4105C4R Atp-dependent dna helicase CDO84_02645 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CDO84_02665 ENOG4108A04 Beta-lactamase CDO84_02680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CDO84_02695 ENOG4105C1G acyl-Coa dehydrogenase CDO84_02725 ENOG4105CRN Aminoglycoside phosphotransferase CDO84_02730 ENOG4105G6Z alkaline phosphatase CDO84_02740 ENOG4105KT7 mgtC SapB transporter CDO84_02745 ENOG4105CK7 Sodium proline symporter CDO84_02750 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CDO84_02755 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CDO84_02760 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CDO84_02775 ENOG4105CBD Diacylglycerol kinase CDO84_02780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CDO84_02835 ENOG4108HFV CDO84_02845 ENOG4108QY0 Membrane CDO84_02860 ENOG4105CDY transcriptional regulatory protein CDO84_02870 ENOG4105M4P Tetr family transcriptional regulator CDO84_02875 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein CDO84_02895 ENOG4105WEF catalase CDO84_02900 ENOG4105M18 -acetyltransferase CDO84_02915 ENOG4105C2F Histidine kinase CDO84_02920 ENOG4105EQD regulatoR CDO84_02925 ENOG410769Z extracellular solute-binding protein family 1 CDO84_02930 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CDO84_02935 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CDO84_02940 ENOG4105F5H Glycosyl Hydrolase Family 88 CDO84_02945 ENOG41075H3 AraC family transcriptional regulator CDO84_02950 ENOG4107TDE lipolytic protein G-D-S-L family CDO84_02965 ENOG4105CX8 fg-gap repeat protein CDO84_02970 ENOG4105CX8 fg-gap repeat protein CDO84_02975 ENOG4107TDE lipolytic protein G-D-S-L family CDO84_02985 ENOG4105EKC CDO84_02990 ENOG4105E0S extracellular solute-binding protein family 1 CDO84_03000 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CDO84_03005 ENOG4105F8D glycoside hydrolase family 4 CDO84_03010 ENOG4105H67 Protein of unknown function (DUF421) CDO84_03015 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CDO84_03020 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CDO84_03040 ENOG4106I4J membrane CDO84_03045 ENOG4108PCN EamA-like transporter family CDO84_03055 ENOG41061H0 Monooxygenase CDO84_03060 ENOG4108R1P CDO84_03065 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CDO84_03070 ENOG4105E0M Sulfatase CDO84_03075 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CDO84_03085 ENOG41090R9 glycosyltransferase CDO84_03090 ENOG4107R51 Glycosyl transferase, family 2 CDO84_03095 ENOG41090R9 glycosyltransferase CDO84_03100 ENOG4105EU0 Major facilitator Superfamily CDO84_03110 ENOG4105CUB amino acid CDO84_03115 ENOG4105C26 Dehydrogenase CDO84_03120 ENOG4105FKZ Methyl-accepting chemotaxis CDO84_03125 ENOG4105C5H ABC transporter CDO84_03135 ENOG4107SWG transcriptional regulator MERR family CDO84_03140 ENOG4105DXB Major Facilitator superfamily CDO84_03145 ENOG4105C5H ABC transporter CDO84_03150 ENOG4105FDU atp-dependent rna helicase CDO84_03160 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CDO84_03165 ENOG4105E0A ABC, transporter CDO84_03170 ENOG4108U1V ABC transporter, permease CDO84_03175 ENOG4105DQ5 transport system permease protein CDO84_03180 ENOG4108HUF Transporter CDO84_03200 ENOG4108J20 pectate lyase CDO84_03205 ENOG4107QPK )-transporter CDO84_03225 ENOG4107TVC Glycosyl transferase, family 2 CDO84_03230 ENOG4108SHN Glycosyl transferase, family 2 CDO84_03240 ENOG4108MRH transcriptional regulatory protein CDO84_03265 ENOG410855V Acylphosphatase CDO84_03270 ENOG4108RPX mosc domain containing protein CDO84_03290 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CDO84_03330 ENOG4105C5Y PTS System CDO84_03335 ENOG4105CG3 alpha amylase, catalytic region CDO84_03340 ENOG4107414 GntR family transcriptional regulator CDO84_03345 ENOG4108RCM Nitroreductase CDO84_03350 ENOG4105CGH 5'-nucleotidase CDO84_03355 ENOG4107RKG DJ-1/PfpI family CDO84_03370 ENOG4105KJF protein tyrosine phosphatase CDO84_03380 ENOG4107U9T Pfam:Ribonuclease_BN CDO84_03385 ENOG4108ISG Major Facilitator CDO84_03390 ENOG4105UPD Calcium Proton CDO84_03400 ENOG4105D8X mechanosensitive ion channel CDO84_03420 ENOG4106KE4 Dehydrogenase CDO84_03425 ENOG4105D7N magnesium and cobalt transport protein CorA CDO84_03435 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CDO84_03450 ENOG4105KNA -acetyltransferase CDO84_03465 ENOG4107RUY (E1 component), alpha subunit CDO84_03475 ENOG4107QKR Dehydrogenase CDO84_03485 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CDO84_03490 ENOG41069DP small acid-soluble spore protein CDO84_03495 ENOG4105KK4 UPF0060 membrane protein CDO84_03520 ENOG4105F8D glycoside hydrolase family 4 CDO84_03525 ENOG4108Q3X Transcriptional regulator CDO84_03530 ENOG4105CI1 PTS System CDO84_03535 ENOG4105BZ1 (ABC) transporter CDO84_03540 ENOG4105BZ1 (ABC) transporter CDO84_03550 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CDO84_03555 ENOG4105BZU Histidine kinase CDO84_03560 ENOG4105WH1 Two component transcriptional regulator luxr family CDO84_03570 ENOG4105CJ1 ABC, transporter CDO84_03575 ENOG41090VJ ABC-2 type transporter CDO84_03580 ENOG4108KYE ABC-2 type transporter CDO84_03590 ENOG4105U3E Transcriptional regulator CDO84_03595 ENOG4105H93 Acyltransferase family CDO84_03600 ENOG4105YA8 Transcriptional regulator CDO84_03605 ENOG4107Y80 Major Facilitator superfamily CDO84_03610 ENOG4108YYS metal-dependent hydrolase (By similarity) CDO84_03615 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDO84_03620 ENOG410834F Transcriptional regulator CDO84_03630 ENOG4108MES Periplasmic binding protein CDO84_03640 ENOG4105DQ5 transport system permease protein CDO84_03645 ENOG4108IHU transport system permease protein CDO84_03650 ENOG4105JAB phenazine biosynthesis protein, phzf family CDO84_03655 ENOG4107Y03 Nitroreductase CDO84_03670 ENOG4105ECP epimerase CDO84_03685 ENOG4105F27 Major Facilitator CDO84_03705 ENOG4106AKJ CDO84_03710 ENOG4105D74 hydrolase CDO84_03715 ENOG4105CKK Glycosyl transferase, family 2 CDO84_03720 ENOG4105EJV Membrane CDO84_03725 ENOG41067AE Membrane-bound metal-dependent hydrolase CDO84_03730 ENOG4105CEN a g-specific adenine glycosylase CDO84_03735 ENOG4106BXE CDO84_03740 ENOG4105CAN Short-chain dehydrogenase reductase Sdr CDO84_03755 ENOG4105EVI UPF0374 protein CDO84_03760 ENOG4105BZ1 (ABC) transporter CDO84_03765 ENOG4107NBY Membrane CDO84_03775 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CDO84_03780 ENOG4105G5W regulator Fur family CDO84_03890 ENOG4108N23 SpoOM-related protein CDO84_03905 ENOG4105EC3 peptidase S51, dipeptidase E CDO84_03910 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CDO84_03915 ENOG4105DNP FAD linked oxidase domain protein CDO84_03930 ENOG4105E2Y ABC, transporter CDO84_03935 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CDO84_03940 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CDO84_03945 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CDO84_03955 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CDO84_03960 ENOG4107D63 CDO84_03965 ENOG4105VZ8 Transcriptional regulator CDO84_03980 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CDO84_03990 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CDO84_04010 ENOG4105CYN Serine protein kinase CDO84_04015 ENOG4106AKX UPF0229 protein CDO84_04020 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CDO84_04025 ENOG4105CW7 secretion protein, HlyD family CDO84_04030 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDO84_04035 ENOG4105CS1 NAD(P)H quinone oxidoreductase CDO84_04055 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CDO84_04060 ENOG4105CZV ABC transporter CDO84_04065 ENOG4105CJ1 ABC, transporter CDO84_04070 ENOG4108TU7 Inherit from COG: (ABC) transporter CDO84_04075 ENOG4105VEQ Cold shock protein CDO84_04090 ENOG4105BZU Histidine kinase CDO84_04140 ENOG4108YBP pseudouridine synthase CDO84_04150 ENOG41080XP Cbs domain CDO84_04155 ENOG4107YBY Hydrolase CDO84_04160 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CDO84_04165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CDO84_04170 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CDO84_04180 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CDO84_04185 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CDO84_04195 ENOG4105BZU Histidine kinase CDO84_04200 ENOG4105WH1 Two component transcriptional regulator luxr family CDO84_04235 ENOG4105ED1 spovr family CDO84_04240 ENOG4105G6Z alkaline phosphatase CDO84_04255 ENOG4105BZN citrate synthase CDO84_04260 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CDO84_04265 ENOG4105CUB amino acid CDO84_04270 ENOG4105C8J )-transporter CDO84_04275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CDO84_04290 ENOG4105J37 CDO84_04295 ENOG4108AEY RNA polymerase sigma factor CDO84_04300 ENOG4108FN7 Aldo keto reductase CDO84_04305 ENOG4105F6E Acyl-transferase CDO84_04310 ENOG4105C37 (CBS) domain CDO84_04320 ENOG4105CHM Aminotransferase CDO84_04325 ENOG4105C37 (CBS) domain CDO84_04335 ENOG4105WMR Protein CrcB homolog CDO84_04340 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CDO84_04350 ENOG4105D64 Mechanosensitive ion channel CDO84_04355 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CDO84_04360 ENOG4107VMI polysaccharide deacetylase CDO84_04365 ENOG4105F0I Aminotransferase CDO84_04385 ENOG4105BZ1 (ABC) transporter CDO84_04390 ENOG4105BZ1 (ABC) transporter CDO84_04415 ENOG410839P CDO84_04425 ENOG4106MP8 UPF0754 membrane protein CDO84_04430 ENOG4105WZB UPF0342 protein CDO84_04435 ENOG4105F1N DNA alkylation repair CDO84_04445 ENOG4105D4P Coproporphyrinogen iii oxidase CDO84_04450 ENOG4107S91 Sodium hydrogen exchanger CDO84_04455 ENOG4105NCW Trka-c domain protein CDO84_04465 ENOG4105CGU Enoyl-CoA hydratase CDO84_04475 ENOG4108IUX (ABC) transporter CDO84_04480 ENOG4105RHA ABC transporter, permease CDO84_04485 ENOG4107VRP DNA repair exonuclease CDO84_04490 ENOG4106D4I domain protein CDO84_04495 ENOG4105EQI Metal Dependent Phosphohydrolase CDO84_04505 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CDO84_04550 ENOG4105NBU tryptophan transport protein CDO84_04555 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CDO84_04560 ENOG4105K59 histidine triad (HIT) protein CDO84_04595 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CDO84_04600 ENOG4105BZ4 penicillin-binding protein CDO84_04605 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CDO84_04610 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CDO84_04615 ENOG4105C1Q protoporphyrinogen oxidase CDO84_04625 ENOG4105ECB domain protein CDO84_04635 ENOG41090T1 Membrane CDO84_04645 ENOG4105DER m42 family CDO84_04660 ENOG4106AXD CDO84_04665 ENOG4108RQ5 Beta-lactamase domain-containing protein CDO84_04670 ENOG4105DF9 Lipoate-protein, ligase CDO84_04680 ENOG4105CEY Amp-dependent synthetase and ligase CDO84_04690 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CDO84_04700 ENOG4105KD7 acetyltransferase CDO84_04710 ENOG4108HUF Transporter CDO84_04715 ENOG4107TB6 phosphoglycerate mutase CDO84_04725 ENOG4107F3J Amp-dependent synthetase and ligase CDO84_04730 ENOG4107ZYJ bioY protein CDO84_04735 ENOG4106YBV Methyl-accepting chemotaxis CDO84_04755 ENOG4105XVF Competence transcription factor CDO84_04770 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CDO84_04775 ENOG4105X3H Excalibur domain protein CDO84_04780 ENOG4105E1V na solute symporter CDO84_04785 ENOG4106CAD Protein of unknown function (DUF3311) CDO84_04790 ENOG41060YP CDO84_04805 ENOG4107SCK Monooxygenase CDO84_04810 ENOG4108INS Transcriptional regulator CDO84_04815 ENOG4108KK1 membrane protein AbrB duplication CDO84_04820 ENOG4106K7D Major facilitator family transporter CDO84_04825 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CDO84_04830 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding CDO84_04845 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CDO84_04855 ENOG4105EYH Exonuclease CDO84_04905 ENOG4105ERH Fumarylacetoacetate hydrolase CDO84_04915 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CDO84_04925 ENOG4105CAQ asparagine synthetase CDO84_04935 ENOG4105UQX Mate efflux family protein CDO84_04940 ENOG4106HBX Transcriptional Regulator AraC Family CDO84_04945 ENOG4105ETE Transcriptional regulator (LacI family CDO84_04950 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CDO84_04955 ENOG4105SF0 DinB family CDO84_04960 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CDO84_04965 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CDO84_04970 ENOG4105MYW Pentapeptide repeat protein CDO84_04975 ENOG4107S9D Alpha beta hydrolase CDO84_04980 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CDO84_04985 ENOG4107RIQ Sulfate adenylate transferase CDO84_04990 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CDO84_04995 ENOG4108N5B 2-phosphosulfolactate phosphatase CDO84_05000 ENOG41061P3 phosphosulfolactate synthase CDO84_05010 ENOG4105DIA mandelate racemase muconate lactonizing CDO84_05015 ENOG4107RCC Major Facilitator Superfamily CDO84_05020 ENOG4108SZE gCN5-related N-acetyltransferase CDO84_05025 ENOG4105MA6 gCN5-related N-acetyltransferase CDO84_05035 ENOG4108VPT UPF0234 protein CDO84_05040 ENOG4105QNR S1 RNA binding domain protein CDO84_05060 ENOG4105K7K Transcriptional regulator CDO84_05070 ENOG410751J CDO84_05075 ENOG4105D4Y metalloprotease CDO84_05080 ENOG4105EPR degv family CDO84_05085 ENOG4107AYK membrAne CDO84_05095 ENOG41073B9 CDO84_05100 ENOG4108KP7 hydrolase CDO84_05105 ENOG4108MXZ Esterase CDO84_05110 ENOG4105VG1 fes assembly suf system protein CDO84_05120 ENOG4105IQ5 FAD linked oxidase domain protein CDO84_05130 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CDO84_05145 ENOG4105C8Y Acetylornithine aminotransferase CDO84_05150 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CDO84_05160 ENOG4105DBV ornithine carbamoyltransferase CDO84_05185 ENOG4107RMD Basic membrane lipoprotein CDO84_05200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CDO84_05205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CDO84_05215 ENOG4105C3U ABC transporter CDO84_05220 ENOG4108JQ7 (ABC) transporter CDO84_05235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDO84_05245 ENOG4105C31 Tryptophanyl-tRNA synthetase CDO84_05250 ENOG4108J59 Extracellular solute-binding protein, family 5 CDO84_05255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CDO84_05260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDO84_05270 ENOG4108JQ7 (ABC) transporter CDO84_05285 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CDO84_05290 ENOG4108ZCF integral membrane protein CDO84_05295 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis CDO84_05305 ENOG4105DPN Oligoendopeptidase f CDO84_05320 ENOG4105T58 Dithiol-disulfide isomerase CDO84_05325 ENOG4108Z18 K06886 hemoglobin CDO84_05330 ENOG4105E4C Lytic transglycosylase catalytic CDO84_05335 ENOG4105MIX Adenylate cyclase CDO84_05350 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CDO84_05355 ENOG4105EMS pseudouridine synthase CDO84_05370 ENOG4105ETU transcriptional activator (TenA CDO84_05375 ENOG4108VEU Thiamine monophosphate synthase CDO84_05390 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CDO84_05395 ENOG4105D06 uba thif-type nad fad binding protein CDO84_05400 ENOG4105DWF phosphomethylpyrimidine kinase CDO84_05405 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CDO84_05410 ENOG4107A88 CDO84_05460 ENOG4105ENA helicase CDO84_05475 ENOG4108ZMI UPF0477 protein CDO84_05485 ENOG4105C28 cystathionine CDO84_05490 ENOG4105C28 cystathionine CDO84_05495 ENOG4105D9U N-acetyltransferase CDO84_05500 ENOG4105JHY Membrane CDO84_05525 ENOG4106BHF CDO84_05560 ENOG4105DM4 PTS System CDO84_05565 ENOG4105DG6 mannose-6-phosphate isomerase CDO84_05570 ENOG4105G7B Protein of unknown function (DUF2992) CDO84_05575 ENOG4105VMI -acetyltransferase CDO84_05585 ENOG4108Z66 YbaK ebsC protein CDO84_05605 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CDO84_05615 ENOG4108ZJ4 polysaccharide deacetylase CDO84_05620 ENOG4107CUJ Protein of unknown function (DUF2690) CDO84_05645 ENOG4108IEG Formate dehydrogenase Alpha subunit CDO84_05670 ENOG4106A3M Cytochrome p-450 CDO84_05675 ENOG41087PP glycosyltransferase MGT family CDO84_05685 ENOG4105EXQ uroporphyrinogen iii synthase hem4 CDO84_05690 ENOG4105C4B ABC transporter, permease CDO84_05695 ENOG4108IXI (ABC) transporter CDO84_05705 ENOG4105Q95 Cupin 2, conserved barrel domain protein CDO84_05720 ENOG4105D2H Uronic isomerase CDO84_05725 ENOG4105CT4 transporter CDO84_05730 ENOG4105DG4 malate L-lactate dehydrogenase CDO84_05735 ENOG4105CPQ Dehydrogenase CDO84_05740 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CDO84_05745 ENOG4105DMW Dehydrogenase reductase CDO84_05750 ENOG4108I5G Major Facilitator superfamily CDO84_05755 ENOG4107KJX Transcriptional regulator CDO84_05760 ENOG4107QZW Altronate oxidoreductase CDO84_05765 ENOG4105CTX dehydratase CDO84_05770 ENOG4107TSN permease CDO84_05780 ENOG4105JD4 ATPase yjob CDO84_05795 ENOG41068K0 YCII-related domain CDO84_05800 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CDO84_05805 ENOG4105KWG Pfam:DUF1696 CDO84_05810 ENOG4105K7W phage-related replication protein CDO84_05815 ENOG4105WEF catalase CDO84_05820 ENOG410635T phage-like element pbsx protein CDO84_05865 ENOG4108TFU terminase (Small subunit) CDO84_05870 ENOG4105IG6 Phage terminase, large subunit CDO84_05875 ENOG4108MDF Phage Portal Protein CDO84_05900 ENOG41060SN CDO84_05915 ENOG4105PQS phage protein CDO84_05920 ENOG4105FR7 XkdM protein, phage-like element PBSX CDO84_05925 ENOG4105MTC XkdN-like protein CDO84_05935 ENOG4108FKH Transglycosylase SLT domain CDO84_05940 ENOG4108WZM domain protein CDO84_05945 ENOG4105X7F CDO84_05955 ENOG4105MFU Protein of unknown function (DUF2634) CDO84_05960 ENOG41066EA baseplate J family protein CDO84_05965 ENOG410906S phage-like element pbsx protein xkdt CDO84_05975 ENOG41068G1 CDO84_06005 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CDO84_06020 ENOG4105CJ3 phosphate transporter CDO84_06025 ENOG4107GRR phosphate transport regulator CDO84_06030 ENOG4107R7I amino acid CDO84_06040 ENOG4105EDW glycosyl transferase, family 39 CDO84_06045 ENOG4105CKK Glycosyl transferase, family 2 CDO84_06050 ENOG4105C0H protease CDO84_06060 ENOG4108ME1 Peptidase M55 D-aminopeptidase CDO84_06065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CDO84_06070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDO84_06075 ENOG4105C3U ABC transporter CDO84_06085 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CDO84_06090 ENOG4105DTQ mandelate racemase muconate lactonizing CDO84_06095 ENOG4107SN7 NLP P60 protein CDO84_06100 ENOG4108JQ7 (ABC) transporter CDO84_06105 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CDO84_06110 ENOG4107TUM Amidinotransferase CDO84_06115 ENOG4108S4H thioesterase Superfamily protein CDO84_06120 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CDO84_06140 ENOG4108428 Inherit from COG: -acetyltransferase CDO84_06150 ENOG41080TC multidrug resistance protein CDO84_06155 ENOG4105CIY formyltetrahydrofolate deformylase CDO84_06160 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CDO84_06175 ENOG4105K56 Transcriptional regulator CDO84_06180 ENOG4108ZHJ Organic hydroperoxide resistance protein CDO84_06190 ENOG4107Y2X deaminase CDO84_06195 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CDO84_06200 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CDO84_06210 ENOG4108W7F transporter, permease CDO84_06215 ENOG4108JJB ABC transporter CDO84_06220 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CDO84_06225 ENOG4108X43 YKOF domain protein CDO84_06230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDO84_06235 ENOG41062D9 Histidine kinase CDO84_06245 ENOG4106849 propeptide, pepSY amd peptidase M4 CDO84_06255 ENOG4105CJW magnesium transporter CDO84_06260 ENOG4105V75 Transcriptional regulator CDO84_06305 ENOG4105DQE DNA ligase CDO84_06310 ENOG4105FDF Could be involved in DNA repair (By similarity) CDO84_06315 ENOG4105BZU Histidine kinase CDO84_06320 ENOG4107T5V SNARE associated Golgi CDO84_06325 ENOG4107TS3 membrane protein, TerC CDO84_06330 ENOG4108WZW RNA polymerase sigma CDO84_06340 ENOG410681C small acid-soluble spore protein CDO84_06350 ENOG4105D0M Protease HtpX homolog CDO84_06370 ENOG4108TGC Acyltransferase CDO84_06375 ENOG4105BZU Histidine kinase CDO84_06380 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CDO84_06385 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CDO84_06390 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CDO84_06395 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CDO84_06405 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit CDO84_06410 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CDO84_06415 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CDO84_06420 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CDO84_06440 ENOG4105BZU Histidine kinase CDO84_06445 ENOG41090MY MarR family Transcriptional regulator CDO84_06450 ENOG4105ER2 Ompa motb domain protein CDO84_06455 ENOG4105E14 MotA TolQ exbB proton channel CDO84_06465 ENOG4108K88 Membrane CDO84_06470 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CDO84_06475 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CDO84_06480 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CDO84_06485 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CDO84_06530 ENOG4105F0V Cell wall hydrolase CDO84_06545 ENOG4105C59 p-type ATPase CDO84_06555 ENOG4105DC7 peptidase M24 CDO84_06565 ENOG4105CID antiterminator CDO84_06575 ENOG4105KRI phosphocarrier protein (HPr CDO84_06580 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CDO84_06590 ENOG4105F6S Spore photoproduct lyase CDO84_06600 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CDO84_06605 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CDO84_06610 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid CDO84_06615 ENOG4105K4I Scp-like extracellular CDO84_06625 ENOG4105BZU Histidine kinase CDO84_06630 ENOG4105CHM Aminotransferase CDO84_06640 ENOG4107R88 Chemotaxis protein (CheV) CDO84_06645 ENOG4105UIN CDO84_06655 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CDO84_06665 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CDO84_06670 ENOG4105EPM Diguanylate phosphodiesterase CDO84_06675 ENOG4107IN1 Protein of unknown function (DUF1797) CDO84_06680 ENOG4108XRC Protein of unknown function (DUF458) CDO84_06710 ENOG4105NQC Flavodoxin CDO84_06720 ENOG4105CH2 amidohydrolase CDO84_06730 ENOG4105D8X mechanosensitive ion channel CDO84_06735 ENOG4105D3R alkyl hydroperoxide reductase CDO84_06740 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CDO84_06755 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CDO84_06760 ENOG4105D06 uba thif-type nad fad binding protein CDO84_06765 ENOG4105CVM Molybdenum cofactor synthesis domain protein CDO84_06770 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CDO84_06775 ENOG4108ZAF Molybdopterin CDO84_06780 ENOG41067WU Molybdopterin converting factor (Subunit 1) CDO84_06785 ENOG4105BZ1 (ABC) transporter CDO84_06790 ENOG4105BZ1 (ABC) transporter CDO84_06800 ENOG4107X8C Efflux transporter RND family MFP subunit CDO84_06805 ENOG4105C19 ABC transporter CDO84_06810 ENOG4107RBB ABC transporter, permease CDO84_06815 ENOG4105E98 transcriptional regulator DeoR family CDO84_06820 ENOG4105DE4 1-phosphofructokinase CDO84_06825 ENOG4105DM4 PTS System CDO84_06830 ENOG4105C3F Signal peptidase i CDO84_06840 ENOG4105C5H ABC transporter CDO84_06845 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CDO84_06870 ENOG4105BZU Histidine kinase CDO84_06880 ENOG4107ZYR domain protein CDO84_06890 ENOG4105CN5 Metallo-Beta-Lactamase CDO84_06900 ENOG4108X4Q Hydrolase CDO84_06905 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CDO84_06925 ENOG4105CPP Dehydrogenase, E1 component CDO84_06930 ENOG4105C7S Dehydrogenase CDO84_06935 ENOG4107QN2 dihydrolipoyl dehydrogenase CDO84_06950 ENOG4105CXN decarboxylase CDO84_06955 ENOG4105WBI UPF0223 protein CDO84_06970 ENOG4105ECY inositol monophosphatase CDO84_06980 ENOG4105JQZ Methyltransferase CDO84_07020 ENOG4105CI3 gtp-binding protein typa CDO84_07025 ENOG4105QA2 CDO84_07040 ENOG4108IAB Phoh family CDO84_07050 ENOG4105CSV Glutaminase CDO84_07055 ENOG4105ZPI UPF0358 protein CDO84_07060 ENOG4105CNI cell division protein FtsW CDO84_07065 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CDO84_07075 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CDO84_07085 ENOG4105BZ9 Cytochrome C oxidase, subunit I CDO84_07090 ENOG4105CCU oxidase (Subunit III) CDO84_07095 ENOG41064X9 cytochrome C oxidase subunit IV CDO84_07110 ENOG41080XQ Signal transduction protein with cbs domains CDO84_07115 ENOG4106UY4 Inherit from COG: Scp-like extracellular CDO84_07135 ENOG4105WUC UPF0298 protein CDO84_07140 ENOG4106H78 methyltransferase CDO84_07145 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CDO84_07150 ENOG4105H20 Sporulation integral membrane protein YlbJ CDO84_07155 ENOG4105D78 K07001 NTE family protein CDO84_07160 ENOG41063PX domain protein CDO84_07165 ENOG4105CDE UPF0348 protein CDO84_07175 ENOG4105KNH Nucleic acid-binding protein CDO84_07180 ENOG41067VY 50S ribosomal protein L32 CDO84_07205 ENOG4108V6E Cell division protein mraZ CDO84_07210 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CDO84_07220 ENOG4105CJN penicillin-binding protein CDO84_07225 ENOG4105CJN penicillin-binding protein CDO84_07230 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CDO84_07235 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CDO84_07240 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CDO84_07245 ENOG4105CNI cell division protein FtsW CDO84_07250 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CDO84_07255 ENOG4105D4A Cell wall formation (By similarity) CDO84_07260 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CDO84_07265 ENOG4108R2U division initiation protein CDO84_07275 ENOG4105K67 small basic protein CDO84_07280 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CDO84_07285 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CDO84_07295 ENOG4105FFI sigma-e processing peptidase spoiiga CDO84_07300 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDO84_07310 ENOG4105DKW ABC transporter CDO84_07320 ENOG4105WR5 sporulation protein, YlmC YmxH family CDO84_07325 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CDO84_07330 ENOG4105DFA alanine racemase domain protein CDO84_07335 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CDO84_07340 ENOG41067XK integral membrane protein CDO84_07345 ENOG4105DBK s4 domain protein CDO84_07355 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CDO84_07365 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CDO84_07370 ENOG4105C34 Pseudouridine synthase CDO84_07375 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CDO84_07385 ENOG4105CXT aspartate transcarbamylase CDO84_07395 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CDO84_07400 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CDO84_07405 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CDO84_07410 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CDO84_07415 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CDO84_07420 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CDO84_07425 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CDO84_07435 ENOG4107S4M Sulfate adenylate transferase CDO84_07440 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CDO84_07445 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CDO84_07450 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CDO84_07455 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CDO84_07460 ENOG4105F23 Fibronectin-binding protein CDO84_07470 ENOG4105DSJ YicC domain protein CDO84_07475 ENOG4105KC4 UPF0296 protein CDO84_07480 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CDO84_07490 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CDO84_07495 ENOG4105C25 Primosomal protein n' CDO84_07500 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CDO84_07505 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CDO84_07510 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CDO84_07515 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CDO84_07520 ENOG4108ZF3 Phosphatase CDO84_07525 ENOG4105D9P serine threonine protein kinase CDO84_07530 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CDO84_07535 ENOG4105DJV ribulose-phosphate 3-epimerase CDO84_07540 ENOG4105FJ0 thiamine CDO84_07550 ENOG4105VB9 50S ribosomal protein l28 CDO84_07555 ENOG4108ZAA Alkaline-shock protein CDO84_07560 ENOG4105DP4 dak2 domain fusion protein ylov CDO84_07570 ENOG4105EJQ L-serine dehydratase CDO84_07575 ENOG4105CB5 ATP-dependent DNA helicase recG CDO84_07580 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CDO84_07590 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CDO84_07595 ENOG4105CHR reductase CDO84_07600 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CDO84_07605 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CDO84_07610 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CDO84_07615 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CDO84_07625 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CDO84_07635 ENOG4105K5M 30s ribosomal protein S16 CDO84_07640 ENOG4108BW8 UPF0109 protein CDO84_07650 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CDO84_07655 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CDO84_07660 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CDO84_07665 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CDO84_07670 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CDO84_07680 ENOG4105VM1 flagellar CDO84_07685 ENOG4105CMV Succinyl-CoA synthetase subunit beta CDO84_07690 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CDO84_07695 ENOG4105C79 DNA protecting protein DprA CDO84_07700 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CDO84_07705 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CDO84_07710 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CDO84_07715 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CDO84_07720 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CDO84_07730 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CDO84_07735 ENOG4108ZC9 flagellar basal-body rod protein flgc CDO84_07740 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CDO84_07745 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CDO84_07750 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CDO84_07765 ENOG4106YF4 Flagellar biosynthesis chaperone CDO84_07775 ENOG410696Y Flagellar hook-length control protein CDO84_07780 ENOG410822I Flagellar hook capping protein CDO84_07785 ENOG4108JQA flagellar CDO84_07790 ENOG41068WV flagellar FlbD family protein CDO84_07800 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CDO84_07805 ENOG4105DD5 Flagellar motor switch protein CDO84_07810 ENOG4107YTP response regulator receiver protein CDO84_07820 ENOG4105CN7 Flagellar biosynthetic protein FliP CDO84_07825 ENOG4105VS8 Flagellar biosynthetic protein fliq CDO84_07830 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CDO84_07835 ENOG4105D00 flagellar biosynthetic protein flhB CDO84_07840 ENOG4105D7B Flagellar biosynthesis protein flha CDO84_07845 ENOG4105FZW flagellar biosynthesis regulator FlhF CDO84_07855 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CDO84_07860 ENOG4105CBS Chea signal transduction histidine kinase CDO84_07865 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CDO84_07880 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDO84_07890 ENOG4105CE9 30S ribosomal protein S2 CDO84_07895 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CDO84_07905 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CDO84_07910 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CDO84_07915 ENOG4105KNE Phosphatidate cytidylyltransferase CDO84_07925 ENOG4105DZP Membrane-associated zinc metalloprotease CDO84_07930 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CDO84_07935 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CDO84_07940 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CDO84_07945 ENOG4105CHV Transcription elongation factor NusA CDO84_07950 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CDO84_07955 ENOG4105VHM ribosomal protein CDO84_07960 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CDO84_07965 ENOG4105W7A Protein of unknown function (DUF503) CDO84_07970 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CDO84_07975 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CDO84_07980 ENOG4105DTN riboflavin biosynthesis protein ribF CDO84_07985 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CDO84_07990 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CDO84_08000 ENOG4105C1V Peptidase, M16 CDO84_08010 ENOG4105E35 Dipicolinate synthase subunit A CDO84_08015 ENOG4108S0H Dipicolinic acid synthetase, b subunit CDO84_08020 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CDO84_08030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CDO84_08040 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CDO84_08050 ENOG4105CNU cell division protein FtsK CDO84_08055 ENOG4105FDP GntR family transcriptional regulator CDO84_08075 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CDO84_08080 ENOG4105XZV Protein of unknown function (DUF3243) CDO84_08095 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CDO84_08100 ENOG4105CEV competence damage-inducible protein CDO84_08110 ENOG4108A04 Beta-lactamase CDO84_08115 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CDO84_08120 ENOG4105D48 metallophosphoesterase CDO84_08125 ENOG4105MCT stage V sporulation protein S CDO84_08135 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CDO84_08140 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CDO84_08155 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CDO84_08160 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CDO84_08200 ENOG4105IIP Membrane CDO84_08205 ENOG4105W1N transcriptional regulator CDO84_08210 ENOG4108151 Beta-lactamase domain protein CDO84_08220 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CDO84_08230 ENOG4107QKG PfaD family CDO84_08235 ENOG41062T2 Acyl carrier protein CDO84_08240 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase CDO84_08245 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CDO84_08250 ENOG4108MGH Enoyl-CoA hydratase CDO84_08255 ENOG4108KQ6 Enoyl-CoA hydratase CDO84_08260 ENOG4105C0W non-ribosomal peptide synthetase CDO84_08265 ENOG4107SQU synthase CDO84_08275 ENOG4105C0W non-ribosomal peptide synthetase CDO84_08285 ENOG4106A3M Cytochrome p-450 CDO84_08300 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CDO84_08310 ENOG4105K7W phage-related replication protein CDO84_08315 ENOG4108X3M OsmC Ohr family protein CDO84_08320 ENOG410814C multidrug resistance protein CDO84_08340 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CDO84_08345 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CDO84_08360 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CDO84_08365 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDO84_08370 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDO84_08375 ENOG4105U6W MutT NUDIX family protein CDO84_08380 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CDO84_08390 ENOG4106F1P AAA ATPase, central domain protein CDO84_08395 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CDO84_08400 ENOG4105CXI aluminum resistance protein CDO84_08405 ENOG4105KV4 Transcriptional regulator CDO84_08410 ENOG4105C5F glutamine synthetase CDO84_08430 ENOG4106BHF CDO84_08450 ENOG4106ANW SMI1_KNR4 CDO84_08455 ENOG4106BHF CDO84_08460 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CDO84_08490 ENOG410907G CDO84_08495 ENOG4105CT4 transporter CDO84_08500 ENOG4105DSG hydrolase family 43 CDO84_08510 ENOG4105C93 Xylose Isomerase CDO84_08515 ENOG4105CMG Carbohydrate kinase CDO84_08525 ENOG4107Y9E nuclease CDO84_08530 ENOG4105C54 Major Facilitator superfamily CDO84_08535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CDO84_08545 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CDO84_08555 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CDO84_08620 ENOG4105FVX CDO84_08630 ENOG4105K7W phage-related replication protein CDO84_08640 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CDO84_08650 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CDO84_08660 ENOG4108SVB resolvase CDO84_08665 ENOG4105VPS UPF0291 protein CDO84_08670 ENOG4105CV1 Transketolase (EC 2.2.1.1) CDO84_08690 ENOG4107QIV Cytochrome c biogenesis protein CDO84_08715 ENOG4107DZX Small, acid-soluble spore protein P CDO84_08725 ENOG4108I0Z Aconitate hydratase CDO84_08730 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CDO84_08745 ENOG41067CD Small, acid-soluble spore protein Tlp CDO84_08755 ENOG4105MI2 CDO84_08760 ENOG4105W8X HesB YadR YfhF-family protein CDO84_08765 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CDO84_08770 ENOG4105K4P CoA-binding domain protein CDO84_08775 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CDO84_08805 ENOG4108MYR Secreted protein CDO84_08810 ENOG4107SYN Glycosyl hydrolases family 43 CDO84_08820 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CDO84_08825 ENOG4107T5V SNARE associated Golgi CDO84_08835 ENOG4107QX3 carboxylase CDO84_08840 ENOG4105E39 Enoyl-CoA hydratase CDO84_08845 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CDO84_08850 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CDO84_08855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CDO84_08860 ENOG4105CEY Amp-dependent synthetase and ligase CDO84_08865 ENOG4105C1G acyl-Coa dehydrogenase CDO84_08885 ENOG4105F32 YngK protein CDO84_08890 ENOG4106U2H Protein of unknown function (DUF1360) CDO84_08900 ENOG4105CEY Amp-dependent synthetase and ligase CDO84_08905 ENOG4105C0W non-ribosomal peptide synthetase CDO84_08915 ENOG4105C0W non-ribosomal peptide synthetase CDO84_08920 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CDO84_08925 ENOG4108N2V aldose 1-epimerase CDO84_08930 ENOG4107QJQ Mate efflux family protein CDO84_08955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CDO84_08960 ENOG4105SKE transcriptional Regulator LysR family CDO84_08965 ENOG4105CB2 alcohol dehydrogenase CDO84_08970 ENOG4105BZ8 glutamate synthase CDO84_08975 ENOG4105CBC glutamate synthase CDO84_08980 ENOG4105C5Q Transcriptional regulator CDO84_08985 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CDO84_08990 ENOG4105II7 pyrroline-5-carboxylate reductase CDO84_09010 ENOG4108UB7 CDO84_09015 ENOG41068WN CDO84_09030 ENOG4105IE8 Alpha-ketoglutarate permease CDO84_09035 ENOG4107U6E carbohydrate kinase FGGY CDO84_09040 ENOG4108M3J Dehydrogenase CDO84_09045 ENOG4108J2R molybdopterin oxidoreductase CDO84_09070 ENOG4105EC8 Methyl-accepting chemotaxis CDO84_09080 ENOG4108YQE rare lipoprotein a CDO84_09085 ENOG4105XPP Protein of unknown function (DUF1275) CDO84_09090 ENOG4108NR7 pectate lyase CDO84_09095 ENOG4108RAV Conserved protein CDO84_09100 ENOG4105F0F Oxalate decarboxylase CDO84_09110 ENOG4105EPI acetyltransferase, (GNAT) family CDO84_09125 ENOG41073R8 VanW family CDO84_09140 ENOG4105NX3 Membrane CDO84_09150 ENOG4108Q5Y Membrane CDO84_09175 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CDO84_09195 ENOG4107T94 Endo-14-beta-xylanase CDO84_09300 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CDO84_09305 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CDO84_09310 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CDO84_09335 ENOG4106ANW SMI1_KNR4 CDO84_09340 ENOG4106BHF CDO84_09365 ENOG4107R39 (ABC) transporter CDO84_09380 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CDO84_09395 ENOG4108Z7R Chaperone CsaA CDO84_09400 ENOG4105FTV AraC Family Transcriptional Regulator CDO84_09405 ENOG4108HJF gCN5-related N-acetyltransferase CDO84_09415 ENOG4108W8B Beta-lactamase domain protein CDO84_09425 ENOG4105D29 Helix-turn-helix type 11 domain protein CDO84_09435 ENOG4105KTU Transcriptional regulator, arsr family CDO84_09445 ENOG4108SJC Membrane CDO84_09465 ENOG4105ECK Fatty Acid Desaturase CDO84_09470 ENOG4108ZGX Histidine kinase CDO84_09475 ENOG4108S01 response regulator CDO84_09480 ENOG41069ER domain protein CDO84_09485 ENOG4105C9U ATP-dependent DNA helicase RecQ CDO84_09500 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CDO84_09505 ENOG4105SCY DNAK suppressor CDO84_09545 ENOG4105C26 Dehydrogenase CDO84_09550 ENOG4105EWU Squalene--hopene cyclase CDO84_09555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CDO84_09560 ENOG4105C8J )-transporter CDO84_09565 ENOG4105C09 Bile acid CDO84_09570 ENOG4105C7S Dehydrogenase CDO84_09580 ENOG4107T89 von Willebrand factor, type A CDO84_09585 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CDO84_09595 ENOG4105K4H Nlp p60 protein CDO84_09600 ENOG41087PP glycosyltransferase MGT family CDO84_09610 ENOG4107QMU Mate efflux family protein CDO84_09615 ENOG4106SCS STAS domain CDO84_09635 ENOG4105FR1 rard protein CDO84_09655 ENOG41090U3 tautomerase CDO84_09670 ENOG4105FBA Phospholipase Carboxylesterase CDO84_09685 ENOG4105E1V na solute symporter CDO84_09705 ENOG4108VXD carboxy-peptidase CDO84_09710 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CDO84_09720 ENOG4106Z5R CDO84_09725 ENOG410841Q phosphoesterase PA-phosphatase related protein CDO84_09755 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CDO84_09760 ENOG4108TSC N-acetyltransferase CDO84_09765 ENOG4107S4Y M20 DapE family protein YgeY CDO84_09780 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CDO84_09815 ENOG4107T32 3-phytase (EC 3.1.3.8) CDO84_09820 ENOG4105C5E polysaccharide biosynthesis protein CDO84_09825 ENOG4105E0X reductase CDO84_09830 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CDO84_09850 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) CDO84_09855 ENOG41090WU lipolytic protein G-D-S-L family CDO84_09860 ENOG4108KF3 Electron transport protein SCO1 SenC CDO84_09870 ENOG4105C7B Threonine dehydratase CDO84_09880 ENOG4108UT2 hemolysin iii CDO84_09890 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CDO84_09905 ENOG4107YX5 Pfam:DUF548 CDO84_09910 ENOG4108Y6J UPF0403 protein CDO84_09915 ENOG4105C01 Dihydroxy-acid dehydratase CDO84_09930 ENOG4108V06 Glutathione peroxidase CDO84_09935 ENOG4105CVG Homoserine O-transsuccinylase CDO84_09975 ENOG41081VK Ribonuclease CDO84_10000 ENOG410890F Dynamin family CDO84_10010 ENOG41065KQ synthase CDO84_10015 ENOG4105C2W permease CDO84_10020 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CDO84_10025 ENOG4105CTD carboxy-peptidase CDO84_10030 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) CDO84_10035 ENOG4108UHU Aldolase CDO84_10040 ENOG4105D7K pfkb domain protein CDO84_10045 ENOG4108M60 Transcriptional regulator CDO84_10055 ENOG4105CHR reductase CDO84_10060 ENOG4105DVT helicase CDO84_10075 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CDO84_10090 ENOG4108UKS UPF0398 protein CDO84_10100 ENOG4107X2U Inherit from COG: Exonuclease-like protein CDO84_10105 ENOG4108I5C dEAD DEAH box helicase CDO84_10155 ENOG4105BZ4 penicillin-binding protein CDO84_10165 ENOG4105CSM endonuclease III CDO84_10175 ENOG4105C5S asparaginyl-tRNA synthetase CDO84_10180 ENOG4105CHM Aminotransferase CDO84_10190 ENOG4105YAC CDO84_10195 ENOG4105DVT helicase CDO84_10200 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CDO84_10205 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CDO84_10210 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CDO84_10215 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CDO84_10220 ENOG4105DJ0 Poly(A) Polymerase CDO84_10225 ENOG4105CPK Glycosyl transferase (Group 1 CDO84_10230 ENOG4105FJR Lmbe family CDO84_10235 ENOG4108Z5K methylglyoxal synthase CDO84_10240 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CDO84_10245 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CDO84_10250 ENOG4108JYZ YitT family CDO84_10270 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CDO84_10290 ENOG41068YB TPR repeat-containing protein CDO84_10295 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CDO84_10305 ENOG4105CIH Imidazole acetol-phosphate transaminase CDO84_10315 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CDO84_10320 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CDO84_10330 ENOG4108I0Q anthranilate phosphoribosyltransferase CDO84_10335 ENOG4105CRQ synthase (Component I) CDO84_10340 ENOG4105KHN chorismate mutase CDO84_10345 ENOG4105D49 3-dehydroquinate synthase CDO84_10350 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CDO84_10355 ENOG4105BZU Histidine kinase CDO84_10360 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CDO84_10365 ENOG4105EAH synthase CDO84_10370 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CDO84_10375 ENOG4105XXQ heptaprenyl diphosphate synthase component I CDO84_10385 ENOG4105EUJ GTP cyclohydrolase i CDO84_10390 ENOG4105K70 DNA-binding protein CDO84_10395 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CDO84_10410 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CDO84_10415 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CDO84_10420 ENOG41065D1 CDO84_10425 ENOG4105S2F CDO84_10440 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CDO84_10445 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CDO84_10450 ENOG4105CAT Cytidine monophosphate kinase CDO84_10465 ENOG4105MSI germination protein ypeb CDO84_10475 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CDO84_10480 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CDO84_10495 ENOG4107RGJ metallophosphoesterase CDO84_10510 ENOG4105I7S Abortive infection protein CDO84_10515 ENOG4105C9U ATP-dependent DNA helicase RecQ CDO84_10520 ENOG4105T7X CDO84_10530 ENOG4108SAX Membrane CDO84_10535 ENOG4108JQ1 Dehydrogenase CDO84_10540 ENOG4105FF2 Type I DHQase CDO84_10555 ENOG4105BZU Histidine kinase CDO84_10560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDO84_10565 ENOG4105CRE cytochrome C CDO84_10570 ENOG4107TWT Cytochrome c biogenesis protein CDO84_10580 ENOG4105FE9 pseudouridine synthase CDO84_10590 ENOG4108JIC nucleoside recognition domain protein CDO84_10595 ENOG4105DZ1 carboxypeptidase CDO84_10605 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CDO84_10610 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CDO84_10625 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CDO84_10630 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CDO84_10635 ENOG4108R6K riboflavin synthase, subunit alpha CDO84_10640 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CDO84_10650 ENOG4105C3F Signal peptidase i CDO84_10660 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) CDO84_10675 ENOG4107ZE5 PPIases accelerate the folding of proteins CDO84_10685 ENOG4105PTM secreted protein CDO84_10690 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CDO84_10700 ENOG4105G6R Stage v sporulation protein ae CDO84_10710 ENOG4105CZ3 stage V sporulation protein ad CDO84_10715 ENOG41090VF Stage v sporulation protein ac CDO84_10730 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDO84_10735 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CDO84_10740 ENOG41082AN stage II sporulation protein CDO84_10745 ENOG4105DZ1 carboxypeptidase CDO84_10750 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CDO84_10755 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CDO84_10760 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CDO84_10770 ENOG4105I3K Ferric uptake regulator, Fur family CDO84_10775 ENOG4105MZ9 stage II sporulation protein m CDO84_10790 ENOG4105DFD Na H antiporter CDO84_10795 ENOG4108IJ0 Aspartate ammonia-lyase CDO84_10800 ENOG4105HDK L-asparaginase CDO84_10805 ENOG4108IMY Transcriptional regulator CDO84_10815 ENOG4108YZ4 nudix hydrolase CDO84_10825 ENOG4105CPC Aldo Keto reductase CDO84_10845 ENOG4106HZJ CDO84_10850 ENOG4105RHY Pfam:UPF0157 CDO84_10855 ENOG4105KAC Antibiotic biosynthesis monooxygenase CDO84_10860 ENOG4108XET gCN5-related N-acetyltransferase CDO84_10870 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CDO84_10880 ENOG4105E5W Transporter CDO84_10890 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase CDO84_10905 ENOG4108IXY short-chain dehydrogenase reductase CDO84_10910 ENOG41069FQ Metallo-beta-lactamase superfamily CDO84_10915 ENOG4105II7 pyrroline-5-carboxylate reductase CDO84_10925 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CDO84_10935 ENOG410861F 50S ribosomal protein L33 CDO84_10940 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CDO84_10945 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CDO84_10950 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CDO84_10955 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CDO84_10965 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) CDO84_10970 ENOG4108NA0 Uncharacterized conserved protein (COG2071) CDO84_10975 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CDO84_10980 ENOG4108HNZ carboxyl transferase CDO84_10985 ENOG4108ZVT methylmalonyl-coA epimerase CDO84_10990 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CDO84_10995 ENOG4108QEG Membrane CDO84_11000 ENOG4105CDA abc transporter atp-binding protein CDO84_11005 ENOG4105E5Q amino acid AbC transporter CDO84_11010 ENOG4108HW3 (ABC) transporter CDO84_11015 ENOG4108Y6J UPF0403 protein CDO84_11020 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CDO84_11035 ENOG4105C7S Dehydrogenase CDO84_11040 ENOG4105CPP Dehydrogenase, E1 component CDO84_11055 ENOG4105CKM Branched-chain carboxylic acid kinase CDO84_11060 ENOG4107RDP Dehydrogenase CDO84_11070 ENOG4108JUB Transcriptional regulator CDO84_11075 ENOG4106CCJ Protein of unknown function (DUF2627) CDO84_11080 ENOG4105CR4 methylisocitrate lyase CDO84_11085 ENOG4105DXD 2-methylcitrate dehydratase CDO84_11095 ENOG4105C1G acyl-Coa dehydrogenase CDO84_11100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CDO84_11110 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CDO84_11115 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CDO84_11125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CDO84_11135 ENOG4107QQR Sporulation CDO84_11145 ENOG4105S1Z Stage IV sporulation protein B CDO84_11150 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CDO84_11155 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CDO84_11160 ENOG4105DX0 Hemolysin A CDO84_11170 ENOG4105CTB Polyprenyl synthetase CDO84_11175 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CDO84_11180 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CDO84_11185 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CDO84_11190 ENOG4105M7K Involved in the transcription termination process (By similarity) CDO84_11195 ENOG4108ZSR alkaline shock protein CDO84_11200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CDO84_11220 ENOG410644B Stage III sporulation protein af CDO84_11230 ENOG4105KQ4 Stage iii sporulation protein ad CDO84_11235 ENOG4108CQH stage III sporulation protein AC CDO84_11240 ENOG4105KR5 Stage iii sporulation protein CDO84_11245 ENOG4105CD2 stage iii sporulation protein aa CDO84_11255 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CDO84_11260 ENOG4105DC7 peptidase M24 CDO84_11265 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CDO84_11275 ENOG4105CBJ Metal-dependent enzyme CDO84_11290 ENOG4105KST dependent repressor CDO84_11295 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CDO84_11300 ENOG4105WZW rhodanese family CDO84_11305 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CDO84_11310 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CDO84_11315 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CDO84_11320 ENOG4105C0D helicase CDO84_11335 ENOG4108IMY Transcriptional regulator CDO84_11345 ENOG4105VFR signal peptidase CDO84_11405 ENOG41080XP Cbs domain CDO84_11415 ENOG4105C37 (CBS) domain CDO84_11440 ENOG4105C5X domain protein CDO84_11465 ENOG4105E0M Sulfatase CDO84_11480 ENOG4107ZXI Rhomboid family CDO84_11490 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CDO84_11495 ENOG4105WDJ 50S ribosomal protein L33 CDO84_11515 ENOG41068DG YceG-like family CDO84_11520 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CDO84_11525 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CDO84_11530 ENOG4105E2Z phosphate ABC transporter (Permease CDO84_11535 ENOG4105C8U phosphate abc transporter CDO84_11540 ENOG4105CVA phosphate CDO84_11545 ENOG4107RF6 penicillin-binding protein CDO84_11555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CDO84_11560 ENOG4105SXS Protein of unknown function (DUF456) CDO84_11575 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CDO84_11580 ENOG41063Y9 CDO84_11585 ENOG4108U5J '-nucleotidase CDO84_11590 ENOG4105N80 Ferric uptake regulator, Fur family CDO84_11595 ENOG4108JYZ YitT family CDO84_11600 ENOG41069ZM Protein of unknown function (DUF2624) CDO84_11605 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CDO84_11620 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CDO84_11625 ENOG4105EGD dinuclear metal center protein, YbgI family CDO84_11645 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDO84_11650 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CDO84_11655 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 CDO84_11660 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CDO84_11670 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CDO84_11675 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CDO84_11680 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CDO84_11690 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CDO84_11695 ENOG4105KG3 cytidine deaminase CDO84_11700 ENOG4107YR5 Diacylglycerol kinase CDO84_11705 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CDO84_11710 ENOG4105CTJ Metal Dependent Phosphohydrolase CDO84_11715 ENOG4105C9A Phoh family CDO84_11720 ENOG4105EI1 sporulation protein yqfd CDO84_11725 ENOG41068P3 sporulation protein YqfC CDO84_11735 ENOG4105DI5 UPF0365 protein CDO84_11740 ENOG4105F7J membrane-bound serine protease CDO84_11745 ENOG4105KTH gatB Yqey CDO84_11760 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CDO84_11765 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CDO84_11770 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CDO84_11780 ENOG4105CFG Acts as a chaperone (By similarity) CDO84_11785 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CDO84_11790 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CDO84_11795 ENOG4105CSA Coproporphyrinogen iii oxidase CDO84_11800 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CDO84_11810 ENOG4108ZRV stage ii sporulation protein p CDO84_11815 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) CDO84_11820 ENOG41082YS Binds directly to 16S ribosomal RNA CDO84_11825 ENOG4105TQK DNA polymerase iii, delta' subunit CDO84_11835 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CDO84_11840 ENOG4108UK2 deaminase CDO84_11845 ENOG4105KQC Competence protein CDO84_11855 ENOG4108D32 Methyltransferase CDO84_11865 ENOG4108WF2 Metal Dependent Phosphohydrolase CDO84_11870 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CDO84_11875 ENOG410812S Rna-binding protein CDO84_11880 ENOG4105E2X shikimate dehydrogenase CDO84_11885 ENOG4105CQW ribosome biogenesis GTPase YqeH CDO84_11890 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CDO84_11905 ENOG41080BT SNARE associated Golgi CDO84_11920 ENOG4105WFK nuclease CDO84_11925 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDO84_11930 ENOG4107Y5K Resolvase CDO84_11975 ENOG4108SHN Glycosyl transferase, family 2 CDO84_11980 ENOG4107TVC Glycosyl transferase, family 2 CDO84_12000 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CDO84_12060 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CDO84_12095 ENOG410906S phage-like element pbsx protein xkdt CDO84_12100 ENOG41066EA baseplate J family protein CDO84_12105 ENOG4105MFU Protein of unknown function (DUF2634) CDO84_12115 ENOG4105X7F CDO84_12120 ENOG4108WZM domain protein CDO84_12125 ENOG4108FKH Transglycosylase SLT domain CDO84_12135 ENOG4105MTC XkdN-like protein CDO84_12150 ENOG4105FR7 XkdM protein, phage-like element PBSX CDO84_12155 ENOG4105PQS phage protein CDO84_12170 ENOG41060SN CDO84_12205 ENOG4106CGH Phage Mu protein F like protein CDO84_12210 ENOG4108MDF Phage Portal Protein CDO84_12215 ENOG4105IG6 Phage terminase, large subunit CDO84_12255 ENOG4105QBX endodeoxyribonuclease RusA CDO84_12275 ENOG4108PNI recT protein CDO84_12280 ENOG4108NF7 phage-type endonuclease CDO84_12310 ENOG41067QW Transcriptional regulator CDO84_12325 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDO84_12365 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CDO84_12385 ENOG41067XF inhibitor CDO84_12400 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CDO84_12410 ENOG4105C7Z Conserved Protein CDO84_12415 ENOG41068VA CDO84_12420 ENOG41087NI Sulfite exporter TauE/SafE CDO84_12425 ENOG4105VFE sira family CDO84_12435 ENOG4105VFE sira family CDO84_12440 ENOG4105C72 UPF0176 protein CDO84_12445 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CDO84_12450 ENOG4105XTG Pfam:DUF156 CDO84_12465 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CDO84_12475 ENOG41090E6 transcriptional regulator MERR family CDO84_12510 ENOG4105XRQ Xanthine dehydrogenase accessory factor CDO84_12530 ENOG4105H3G oxidoreductase CDO84_12535 ENOG4105PGM cation diffusion facilitator family transporter CDO84_12545 ENOG41066EA baseplate J family protein CDO84_12555 ENOG41064BW Protein of unknown function (DUF2568) CDO84_12565 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CDO84_12575 ENOG4105EA8 2-Nitropropane dioxygenase CDO84_12580 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CDO84_12590 ENOG4107YCY Transcriptional regulator CDO84_12600 ENOG4105CHR reductase CDO84_12605 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CDO84_12610 ENOG4105CV1 Transketolase (EC 2.2.1.1) CDO84_12615 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDO84_12620 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CDO84_12625 ENOG4108MEK Metal-binding protein YodA CDO84_12635 ENOG41083Q9 chitosanase CDO84_12640 ENOG4105X5K response regulator receiver protein CDO84_12645 ENOG4108VQT Alpha beta hydrolase fold protein CDO84_12650 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein CDO84_12655 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein CDO84_12660 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase CDO84_12670 ENOG4105PGS Spore coat protein CDO84_12675 ENOG4105E2A Dehydrogenase CDO84_12690 ENOG4108HKT sucrose-6-phosphate hydrolase CDO84_12695 ENOG4105F3R pts system mannose fructose sorbose family iid CDO84_12700 ENOG4105ETZ PTS System CDO84_12705 ENOG4108IQ3 PTS system CDO84_12710 ENOG4105YHU PTS system CDO84_12715 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CDO84_12720 ENOG4105C85 amino acid CDO84_12725 ENOG4105N14 lysine exporter protein LysE YggA CDO84_12730 ENOG4108NGU Transcriptional regulator CDO84_12735 ENOG4105JVQ RNA Polymerase CDO84_12740 ENOG4108P49 AntiSigma factor CDO84_12745 ENOG4105EXC Acyl-transferase CDO84_12750 ENOG4105WDR CDO84_12755 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CDO84_12760 ENOG41082JN Transcriptional regulator CDO84_12775 ENOG4105TMB Formate nitrite transporter CDO84_12780 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CDO84_12785 ENOG4108JB9 formate dehydrogenase CDO84_12800 ENOG4105C28 cystathionine CDO84_12815 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CDO84_12830 ENOG4107XRG penicillin-binding protein CDO84_12835 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CDO84_12840 ENOG4105DBI uridine monophosphokinase CDO84_12845 ENOG4105CFP Peptidase U32 CDO84_12850 ENOG4105XYU peptidase (U32 family) CDO84_12855 ENOG4108VQJ O-methyltransferase CDO84_12860 ENOG4105HHA aminodeoxychorismate lyase CDO84_12865 ENOG4105VPH UPF0473 protein CDO84_12870 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CDO84_12875 ENOG4105VBH UPF0297 protein CDO84_12880 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CDO84_12885 ENOG4105C02 permease CDO84_12895 ENOG41060CR CDO84_12905 ENOG4105C7H Helicase, RecD TraA family CDO84_12915 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CDO84_12920 ENOG4105C3J Cysteine desulfurase CDO84_12930 ENOG4105D1H recombination factor protein RarA CDO84_12935 ENOG4105CUZ uba thif-type nad fad binding protein CDO84_12945 ENOG4105C9M aspartyl-trna synthetase CDO84_12950 ENOG4105CUT histidyl-tRNA synthetase CDO84_12960 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CDO84_12970 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CDO84_12975 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CDO84_12980 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CDO84_12985 ENOG41067VP Protein of unknown function (DUF1049) CDO84_12990 ENOG4105NCW Trka-c domain protein CDO84_12995 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CDO84_13005 ENOG4105CKP Polysaccharide Biosynthesis Protein CDO84_13010 ENOG4108QG2 Membrane CDO84_13015 ENOG4105NAP CDO84_13020 ENOG4105VIE preprotein translocase, subunit YajC CDO84_13025 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CDO84_13030 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CDO84_13035 ENOG41061AI Protein of unknown function (DUF2905) CDO84_13040 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CDO84_13045 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CDO84_13055 ENOG4105IE8 Alpha-ketoglutarate permease CDO84_13060 ENOG4105CK5 oxidoreductase CDO84_13075 ENOG4105BZG amino acid carrier protein CDO84_13080 ENOG4105CDY transcriptional regulatory protein CDO84_13090 ENOG4106678 morphogenetic protein associated with SpoVID CDO84_13095 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CDO84_13100 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CDO84_13105 ENOG4108IYU L-aspartate oxidase CDO84_13120 ENOG4105CQC Prephenate dehydratase CDO84_13125 ENOG41090I5 UPF0735 ACT domain-containing protein CDO84_13130 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CDO84_13140 ENOG4105K46 50S ribosomal protein l27 CDO84_13145 ENOG4105X36 (ribosomal) protein CDO84_13150 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CDO84_13165 ENOG4107QMS site-determining protein CDO84_13170 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CDO84_13175 ENOG4105YHC Rod shape-determining protein MreD CDO84_13180 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CDO84_13185 ENOG4105DFF Rod shape-determining protein mreb CDO84_13190 ENOG4105W5Q DNA repair protein (RadC CDO84_13195 ENOG4108Z03 MAF-like protein CDO84_13205 ENOG4106A3R peptidase CDO84_13210 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CDO84_13215 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CDO84_13225 ENOG4106AR7 Spore coat protein CDO84_13230 ENOG41068KH stage VI sporulation protein D CDO84_13235 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CDO84_13240 ENOG4105D52 delta-aminolevulinic acid dehydratase CDO84_13250 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CDO84_13260 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CDO84_13270 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CDO84_13275 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CDO84_13280 ENOG4108IUQ atp-dependent protease CDO84_13285 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CDO84_13290 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CDO84_13300 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CDO84_13305 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CDO84_13310 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CDO84_13315 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CDO84_13320 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CDO84_13325 ENOG4108ZP8 Acetolactate synthase small subunit CDO84_13330 ENOG4105C7K acetolactate synthase CDO84_13345 ENOG4105I4A GCN5-related N-acetyltransferase CDO84_13350 ENOG4107KM7 Heat induced stress protein YflT CDO84_13375 ENOG4107SCJ type I restriction enzyme EcoKI subunit R CDO84_13390 ENOG4105M59 Phosphodiesterase, mj0936 family CDO84_13395 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CDO84_13400 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CDO84_13405 ENOG4108XJQ germination protein CDO84_13410 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CDO84_13415 ENOG41067TZ transcriptional regulator, MarR family CDO84_13420 ENOG4105PFC Transcriptional regulator CDO84_13430 ENOG4105E33 succinate dehydrogenase CDO84_13440 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CDO84_13450 ENOG4105CFH Aspartokinase CDO84_13460 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CDO84_13465 ENOG4105K63 Thioredoxin CDO84_13475 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CDO84_13480 ENOG4105C10 Electron transfer flavoprotein CDO84_13485 ENOG4105BZJ Electron transfer flavoprotein CDO84_13490 ENOG41060WC Enoyl-CoA hydratase CDO84_13495 ENOG4107Z3H Transcriptional regulator, TetR family CDO84_13500 ENOG4105CEY Amp-dependent synthetase and ligase CDO84_13510 ENOG4105C98 muts2 protein CDO84_13515 ENOG4105DCG PHP domain protein CDO84_13530 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CDO84_13535 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CDO84_13540 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CDO84_13550 ENOG4108RWN rrna methyltransferase CDO84_13555 ENOG41067MF small acid-soluble spore protein CDO84_13565 ENOG4105CQB FAD linked oxidase domain protein CDO84_13570 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CDO84_13600 ENOG4105K7K Transcriptional regulator CDO84_13605 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CDO84_13610 ENOG4105DRS transport system, permease CDO84_13625 ENOG4108MDK Dehydrogenase CDO84_13635 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CDO84_13640 ENOG4105EF1 ribulokinase CDO84_13650 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase CDO84_13655 ENOG4105CN9 Peptidase m42 family protein CDO84_13665 ENOG410696E Membrane CDO84_13670 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CDO84_13675 ENOG4105VJV 50s ribosomal protein L35 CDO84_13680 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CDO84_13690 ENOG41067MG lrgb family CDO84_13700 ENOG4105DY9 regulatoR CDO84_13705 ENOG4108HRK Histidine kinase CDO84_13710 ENOG4105U0R haloacid dehalogenase-like hydrolase CDO84_13715 ENOG4105C22 threonyL-tRNA synthetase CDO84_13720 ENOG4108TDW sporulation protein YtxC CDO84_13740 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CDO84_13745 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CDO84_13750 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CDO84_13755 ENOG4105KVH Transcriptional regulator CDO84_13760 ENOG4105F27 Major Facilitator CDO84_13765 ENOG4105CV8 reductase CDO84_13770 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CDO84_13780 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CDO84_13785 ENOG4105C2M dna polymerase I CDO84_13790 ENOG4105BZU Histidine kinase CDO84_13795 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CDO84_13800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CDO84_13805 ENOG4108HMX isocitrate dehydrogenase (NADP) CDO84_13810 ENOG4105BZN citrate synthase CDO84_13820 ENOG4108REF Sporulation integral membrane protein ytvi CDO84_13825 ENOG4105FS0 cytoplasmic membrane protein CDO84_13830 ENOG4105CA9 Pyruvate kinase CDO84_13835 ENOG4105CTQ phosphohexokinase CDO84_13845 ENOG4108IEY Carboxyl transferase domain CDO84_13850 ENOG4105C6K Malic enzyme CDO84_13855 ENOG4105C0B DNA polymerase III (alpha subunit) CDO84_13860 ENOG4105VV2 CDO84_13870 ENOG4106EVM CDO84_13875 ENOG4105SFS phosphoesterase RecJ domain protein CDO84_13890 ENOG4105E8R UPF0173 metal-dependent hydrolase CDO84_13905 ENOG4105CH7 arginosuccinase CDO84_13910 ENOG4105CDH Citrulline--aspartate ligase CDO84_13915 ENOG4105EPU Molybdenum cofactor synthesis domain protein CDO84_13920 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CDO84_13935 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CDO84_13940 ENOG4105KBJ sporulation protein ytfj CDO84_13950 ENOG4105VK3 rdd domain containing protein CDO84_13955 ENOG4105D07 Signal peptide peptidase, SppA CDO84_13960 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CDO84_13965 ENOG4105EFZ amidohydrolase CDO84_13970 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CDO84_14005 ENOG4105U5Y Transcriptional regulator CDO84_14015 ENOG4105BZU Histidine kinase CDO84_14025 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CDO84_14030 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CDO84_14045 ENOG4105F1V Acetoin utilization protein CDO84_14050 ENOG4105W87 Cbs domain CDO84_14055 ENOG4105DGU Histone deacetylase CDO84_14060 ENOG4105ER2 Ompa motb domain protein CDO84_14065 ENOG4107R0U MotA TolQ exbB proton channel CDO84_14070 ENOG4105ETE Transcriptional regulator (LacI family CDO84_14075 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CDO84_14095 ENOG4105DFU Cell wall formation (By similarity) CDO84_14105 ENOG4108VDD TRNA binding domain protein CDO84_14120 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ CDO84_14135 ENOG4105C6K Malic enzyme CDO84_14140 ENOG4105C8F Beta-lactamase domain protein CDO84_14145 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CDO84_14155 ENOG4108V15 phosphotransferase enzyme family CDO84_14160 ENOG4108IUM Glycogen debranching enzyme CDO84_14175 ENOG4107F58 2'-5' rna ligase CDO84_14180 ENOG4105C6T cysteine synthase CDO84_14185 ENOG4107QSE Dipeptidase CDO84_14190 ENOG4105C7N Xanthine uracil vitamin C permease CDO84_14205 ENOG4105YW5 deoR family transcriptional regulator CDO84_14220 ENOG4105CBX hi0933 family CDO84_14225 ENOG4105C94 Transporter CDO84_14235 ENOG4105MU9 integral membrane protein CDO84_14240 ENOG4105DDC Oxidoreductase domain protein CDO84_14250 ENOG4105F5H Glycosyl Hydrolase Family 88 CDO84_14260 ENOG41075H3 AraC family transcriptional regulator CDO84_14270 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CDO84_14280 ENOG4106A3M Cytochrome p-450 CDO84_14285 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CDO84_14295 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CDO84_14300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CDO84_14315 ENOG4105NTD Inherit from COG: Hydrolase CDO84_14330 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CDO84_14335 ENOG4105I1K ABC transporter CDO84_14345 ENOG41085GJ domain protein CDO84_14350 ENOG4105C8T Leucyl-tRNA synthetase CDO84_14360 ENOG4105BZU Histidine kinase CDO84_14365 ENOG410605W Major Facilitator CDO84_14370 ENOG4106UBQ CDO84_14380 ENOG4105C19 ABC transporter CDO84_14385 ENOG4105EWM Histidine kinase CDO84_14395 ENOG4107R34 abc transporter permease protein CDO84_14400 ENOG4105C19 ABC transporter CDO84_14415 ENOG4105DVE abc transporter atp-binding protein CDO84_14420 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CDO84_14430 ENOG4105N5T Radical SAM Protein CDO84_14445 ENOG4105E8V Alpha Beta Hydrolase Fold protein CDO84_14450 ENOG4108Z0R Transferase CDO84_14455 ENOG4105C85 amino acid CDO84_14460 ENOG4105CAQ asparagine synthetase CDO84_14465 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CDO84_14470 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CDO84_14485 ENOG4105D2X ABC transporter substrate-binding protein CDO84_14495 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CDO84_14515 ENOG4108RMU ferritin dps family protein CDO84_14530 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CDO84_14535 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CDO84_14540 ENOG4108V2W Carbonate dehydratase CDO84_14565 ENOG4105CC5 ABC transporter CDO84_14570 ENOG4105CC5 ABC transporter CDO84_14575 ENOG4105DIK (ABC) transporter CDO84_14580 ENOG4105DSE periplasmic solute binding protein CDO84_14585 ENOG4105DTQ mandelate racemase muconate lactonizing CDO84_14590 ENOG4105CEY Amp-dependent synthetase and ligase CDO84_14595 ENOG4108IPT Naphthoate synthase CDO84_14600 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CDO84_14605 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CDO84_14610 ENOG4105E4F Isochorismate synthase CDO84_14635 ENOG4108IAJ Nad-dependent epimerase dehydratase CDO84_14640 ENOG4107SBE Glycosyl transferase (Group 1 CDO84_14655 ENOG4107SBE Glycosyl transferase (Group 1 CDO84_14660 ENOG4108KS4 Spore coat protein CDO84_14675 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CDO84_14685 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CDO84_14815 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CDO84_14820 ENOG4105VRR gCN5-related N-acetyltransferase CDO84_14825 ENOG4105DZ6 Band 7 protein CDO84_14835 ENOG4106DF1 CDO84_14840 ENOG4108VNY MOSC domain protein CDO84_14845 ENOG4108JB8 alcohol dehydrogenase CDO84_14850 ENOG4105C26 Dehydrogenase CDO84_14855 ENOG4105TRT Transcriptional regulator CDO84_14870 ENOG4105CZN Potassium uptake protein CDO84_14875 ENOG4107I77 yiaA/B two helix domain CDO84_14880 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CDO84_14905 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CDO84_14915 ENOG4105EE0 oxidoreductase CDO84_14920 ENOG4105DKG l-rhamnose isomerase CDO84_14925 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) CDO84_14930 ENOG4105DET Rhamnulokinase CDO84_14935 ENOG4105E98 transcriptional regulator DeoR family CDO84_14950 ENOG4105C8Q Methyl-accepting chemotaxis CDO84_14955 ENOG4105C8Q Methyl-accepting chemotaxis CDO84_14960 ENOG4105C8Q Methyl-accepting chemotaxis CDO84_14965 ENOG4105C8Q Methyl-accepting chemotaxis CDO84_14980 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CDO84_14990 ENOG4105C37 (CBS) domain CDO84_15005 ENOG4107PBV potassium channel CDO84_15010 ENOG4107PBV potassium channel CDO84_15025 ENOG4107QYV phosphohexose isomerase CDO84_15035 ENOG4107QW4 alcohol dehydrogenase CDO84_15040 ENOG4105WG9 Conserved Protein CDO84_15050 ENOG4105CHM Aminotransferase CDO84_15055 ENOG4108ZB6 transcriptional regulator AsnC family CDO84_15060 ENOG4108MUZ hydrolase CDO84_15070 ENOG4105C87 Aminotransferase class I and II CDO84_15075 ENOG4108HGU Histidine kinase CDO84_15080 ENOG4105Y38 Kinase-associated protein B CDO84_15100 ENOG4105BZ4 penicillin-binding protein CDO84_15105 ENOG4105KIR Thiol-disulfide oxidoreductase dcc CDO84_15120 ENOG4108MRH transcriptional regulatory protein CDO84_15125 ENOG4105DIH basic membrane CDO84_15130 ENOG4108JQ9 ABC transporter CDO84_15135 ENOG4105UIB (ABC) transporter CDO84_15155 ENOG4105D65 subunit l CDO84_15160 ENOG4105HC0 Na H antiporter CDO84_15165 ENOG4108ZE9 Monovalent cation H antiporter subunit C CDO84_15170 ENOG4108JPZ Monovalent cation H antiporter subunit D CDO84_15175 ENOG4105SC1 monovalent cation H antiporter subunit E CDO84_15185 ENOG4105KJM monovalent cation h antiporter subunit g CDO84_15190 ENOG4105KA0 thioesterase Superfamily protein CDO84_15200 ENOG4105BZU Histidine kinase CDO84_15225 ENOG4105D58 Diguanylate phosphodiesterase CDO84_15230 ENOG4105DAP Nicotinate phosphoribosyltransferase CDO84_15255 ENOG4105C02 permease CDO84_15275 ENOG410904N short-chain dehydrogenase reductase CDO84_15310 ENOG4108K8K Transcriptional regulator CDO84_15315 ENOG4105DCF alanine dehydrogenase CDO84_15325 ENOG4105WQT MbtH domain protein CDO84_15330 ENOG4105CEY Amp-dependent synthetase and ligase CDO84_15335 ENOG4105WQI isochorismatase CDO84_15340 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CDO84_15345 ENOG4105E4F Isochorismate synthase CDO84_15350 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CDO84_15355 ENOG4105NIV Esterase CDO84_15375 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CDO84_15385 ENOG41069ER domain protein CDO84_15400 ENOG4105CEP NADH dehydrogenase CDO84_15405 ENOG4105CAY ferredoxin--nadp reductase CDO84_15425 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CDO84_15430 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CDO84_15445 ENOG4105ZKE UPF0349 protein CDO84_15460 ENOG41083MR nifu domain-containing protein CDO84_15465 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CDO84_15470 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CDO84_15475 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CDO84_15480 ENOG4105D6E homoserine dehydrogenase CDO84_15490 ENOG4108W5N phosphatidylglycerophosphatase a CDO84_15495 ENOG4105D4U had-superfamily hydrolase, subfamily iia CDO84_15505 ENOG4105MMD transcriptional regulator CDO84_15510 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CDO84_15515 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CDO84_15520 ENOG4105FAA peptidase M23 CDO84_15525 ENOG4108YTE sporulation protein YunB CDO84_15530 ENOG4105KZD Domain of unknown function (DUF1805) CDO84_15535 ENOG4107R8B 5'-nucleotidase CDO84_15545 ENOG4105I3N Conserved Protein CDO84_15555 ENOG4105CD3 dihydroorotase CDO84_15560 ENOG4105G9B Transcriptional regulator CDO84_15575 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) CDO84_15580 ENOG4105VT2 5-hydroxyisourate hydrolase CDO84_15655 ENOG4107YV9 domain protein CDO84_15660 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CDO84_15675 ENOG4105XRQ Xanthine dehydrogenase accessory factor CDO84_15680 ENOG4105C5R Aminotransferase CDO84_15695 ENOG4108K8S endonuclease I CDO84_15700 ENOG4108IJ9 (ABC) transporter CDO84_15705 ENOG4105FDP GntR family transcriptional regulator CDO84_15710 ENOG4108KPW sugar kinase CDO84_15715 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CDO84_15720 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CDO84_15725 ENOG4105XN3 extracellular solute-binding protein family 1 CDO84_15730 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine CDO84_15735 ENOG4105PKS Excinuclease abc c subunit domain protein CDO84_15740 ENOG4107VFR oxidoreductase CDO84_15755 ENOG4105DIW FeS assembly protein SUFB CDO84_15760 ENOG4108UNV SUF system FeS assembly protein, NifU family CDO84_15765 ENOG4105C9B Cysteine desulfurase CDO84_15770 ENOG4105JRK feS assembly protein SufD CDO84_15775 ENOG4105C3K feS assembly ATPase SufC CDO84_15795 ENOG4105D01 (LipO)protein CDO84_15800 ENOG4108UMI ABC transporter, permease CDO84_15805 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CDO84_15830 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CDO84_15835 ENOG41080E8 Transcriptional regulator, Spx MgsR family CDO84_15840 ENOG4105C1G acyl-Coa dehydrogenase CDO84_15845 ENOG4105CHU acetyl-coa acetyltransferase CDO84_15875 ENOG41067TZ transcriptional regulator, MarR family CDO84_15880 ENOG4105C0R drug resistance transporter emrb qaca subfamily CDO84_15885 ENOG4105MDS 4-oxalocrotonate tautomerase CDO84_15895 ENOG4105EGI Transcriptional regulator CDO84_15905 ENOG4105E0A ABC, transporter CDO84_15970 ENOG4105HUF DNA protection during starvation protein CDO84_15975 ENOG4105C0H protease CDO84_15985 ENOG4105F3H Histidine kinase CDO84_15995 ENOG41067SE Tetr family transcriptional regulator CDO84_16000 ENOG4105C9Q fumarate hydratase class II CDO84_16025 ENOG4105WH1 Two component transcriptional regulator luxr family CDO84_16030 ENOG4105ENE Histidine kinase CDO84_16045 ENOG41087YS Phage shock protein A CDO84_16060 ENOG4108WBT adenosyltransferase CDO84_16065 ENOG4105E0A ABC, transporter CDO84_16070 ENOG4105EHG Permease protein CDO84_16075 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CDO84_16080 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CDO84_16085 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CDO84_16095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CDO84_16105 ENOG4106DF4 Sigma-70, region 4 CDO84_16115 ENOG4105F0F Oxalate decarboxylase CDO84_16125 ENOG4107RBB ABC transporter, permease CDO84_16130 ENOG4105C19 ABC transporter CDO84_16135 ENOG4108WMK Efflux transporter RND family MFP subunit CDO84_16140 ENOG4105E0A ABC, transporter CDO84_16145 ENOG4105EHG Permease protein CDO84_16150 ENOG4105DQ5 transport system permease protein CDO84_16165 ENOG4105D5Q Arginine ornithine antiporter CDO84_16180 ENOG4107K5X Membrane-bound metal-dependent hydrolase CDO84_16185 ENOG4107QZ2 Sulfatase CDO84_16190 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CDO84_16195 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CDO84_16200 ENOG4105E0C molybdate abc transporter CDO84_16215 ENOG4105EEQ Na H antiporter CDO84_16220 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CDO84_16225 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CDO84_16230 ENOG4105EEM helicase CDO84_16235 ENOG4105EN6 Membrane CDO84_16245 ENOG4107ZQN disulfide bond CDO84_16250 ENOG4105C59 p-type ATPase CDO84_16255 ENOG4105C59 p-type ATPase CDO84_16260 ENOG410681U heavy metal transport detoxification protein CDO84_16265 ENOG4105VPX protein, conserved in bacteria CDO84_16270 ENOG4105D9R oxidoreductase CDO84_16275 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CDO84_16280 ENOG4105ME7 Membrane CDO84_16285 ENOG4105RXJ CDO84_16290 ENOG4105KPY Small multidrug resistance protein CDO84_16295 ENOG4105KBX Transcriptional regulator, TetR family CDO84_16300 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CDO84_16310 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CDO84_16315 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CDO84_16325 ENOG4105XZU Preprotein translocase, subunit SecG CDO84_16350 ENOG4105KVH Transcriptional regulator CDO84_16355 ENOG4105C8Q Methyl-accepting chemotaxis CDO84_16360 ENOG4105R40 Glycine betaine carnitine choline CDO84_16365 ENOG4108HQR Glycine betaine CDO84_16370 ENOG4105E90 ABC transporter CDO84_16375 ENOG4108IJ8 ABC transporter CDO84_16380 ENOG4107HG4 Transcriptional regulator CDO84_16385 ENOG4105R40 Glycine betaine carnitine choline CDO84_16390 ENOG4108HQR Glycine betaine CDO84_16395 ENOG4105E90 ABC transporter CDO84_16400 ENOG4108IJ8 ABC transporter CDO84_16405 ENOG4107HG4 Transcriptional regulator CDO84_16410 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CDO84_16425 ENOG4105T65 Membrane-associated protein CDO84_16430 ENOG4108W0I acetyltransferase CDO84_16440 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CDO84_16445 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CDO84_16450 ENOG4105CP7 Triose-phosphate isomerase CDO84_16455 ENOG4105BZA Phosphoglycerate kinase CDO84_16460 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CDO84_16475 ENOG4105CMD Transcriptional regulator, GntR family CDO84_16480 ENOG4105DEN Luciferase family CDO84_16490 ENOG4105GZI Transcriptional regulator CDO84_16495 ENOG4107RT3 EamA-like transporter family CDO84_16505 ENOG4105VRS hydrolase family 18 CDO84_16510 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) CDO84_16515 ENOG4107QR9 Iron-sulfur cluster binding protein CDO84_16520 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CDO84_16530 ENOG4105BZU Histidine kinase CDO84_16535 ENOG4105KCT ABC transporter CDO84_16540 ENOG4108M15 ABC transporter CDO84_16545 ENOG4107R6F Alpha Beta Hydrolase Fold protein CDO84_16550 ENOG4108MJI response regulator CDO84_16565 ENOG4105EG2 ABC transporter, permease CDO84_16575 ENOG4107FKK extracellular solute-binding protein family 1 CDO84_16585 ENOG4105JXH GntR family transcriptional regulator CDO84_16590 ENOG4105DAA L-lactate CDO84_16595 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CDO84_16605 ENOG4108ZPC Polysaccharide pyruvyl transferase CDO84_16610 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CDO84_16615 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family CDO84_16620 ENOG4105D3Q Sugar transferase CDO84_16630 ENOG4105K64 Glycosyl transferase, family 2 CDO84_16640 ENOG4107QRS glycosyltransferase group 2 family protein CDO84_16645 ENOG41068W6 Capsular polysaccharide biosynthesis protein CDO84_16650 ENOG4108KMV Glycosyl transferase (Group 1 CDO84_16655 ENOG4105K64 Glycosyl transferase, family 2 CDO84_16660 ENOG4108PQP glycosyl transferase group 1 CDO84_16670 ENOG4108QV3 biosynthesis protein CDO84_16675 ENOG4105HTX biosynthesis protein CDO84_16685 ENOG4105EBR Carboxylesterase CDO84_16695 ENOG4105PY6 Phenolic acid decarboxylase CDO84_16700 ENOG4105NI3 Protein of unknown function (DUF3237) CDO84_16710 ENOG4105FQP Beta-lactamase CDO84_16715 ENOG4105EDQ levansucrase EC 2.4.1.10 CDO84_16720 ENOG4108HKT sucrose-6-phosphate hydrolase CDO84_16725 ENOG4107QTZ amino acid CDO84_16755 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CDO84_16760 ENOG4107URF beta-phospho-glucomutase CDO84_16765 ENOG4105CG3 alpha amylase, catalytic region CDO84_16780 ENOG4105EG2 ABC transporter, permease CDO84_16785 ENOG4105D56 permease protein CDO84_16790 ENOG4107FKK extracellular solute-binding protein family 1 CDO84_16795 ENOG4108IUK alpha amylase, catalytic CDO84_16800 ENOG4105FKQ transcriptional regulator CDO84_16805 ENOG4108URH decarboxylase CDO84_16810 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain CDO84_16815 ENOG4105CHH sulfate transporter CDO84_16820 ENOG4108V2W Carbonate dehydratase CDO84_16825 ENOG4105C5I Dehydrogenase CDO84_16835 ENOG4105C19 ABC transporter CDO84_16840 ENOG4105EWM Histidine kinase CDO84_16855 ENOG4107A6P CDO84_16860 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CDO84_16865 ENOG4105KRI phosphocarrier protein (HPr CDO84_16870 ENOG4105CIE May be required for sporulation (By similarity) CDO84_16875 ENOG4105CHW UPF0052 protein CDO84_16880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CDO84_16885 ENOG4108Z4K mutator MutT protein CDO84_16890 ENOG4105C3M thioredoxin reductase CDO84_16905 ENOG4105BZ1 (ABC) transporter CDO84_16915 ENOG4106FGC CDO84_16945 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CDO84_16950 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CDO84_16955 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CDO84_16960 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CDO84_16965 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CDO84_16970 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CDO84_16975 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CDO84_16980 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CDO84_16990 ENOG4108E16 pectate lyase CDO84_16995 ENOG4108S4C acetyltransferase CDO84_17000 ENOG4107XGZ Hydrolase CDO84_17005 ENOG4105HKU nucleoside recognition domain-containing protein CDO84_17010 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CDO84_17015 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CDO84_17020 ENOG4105CE4 GlcNAc 6-P deacetylase CDO84_17025 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CDO84_17030 ENOG4105FDP GntR family transcriptional regulator CDO84_17035 ENOG41088CQ domain protein CDO84_17040 ENOG41086DT Membrane protein of unknown function CDO84_17045 ENOG41067S9 phage shock protein C, PspC CDO84_17050 ENOG4108PY7 CDO84_17065 ENOG4105I03 Flagellin CDO84_17070 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CDO84_17075 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CDO84_17090 ENOG4105MKU Transcriptional regulator CDO84_17110 ENOG4105CN1 protease CDO84_17115 ENOG4105CRP Part of the ABC transporter FtsEX involved in CDO84_17120 ENOG4105CAK Cell division ATP-binding protein ftsE CDO84_17145 ENOG4105MS2 ribosomal subunit Interface protein CDO84_17160 ENOG4105MQ3 flagellar protein FliS CDO84_17165 ENOG4107RT6 flagellar hook-associated CDO84_17170 ENOG41083S7 flagellar protein FlaG CDO84_17175 ENOG4105I03 Flagellin CDO84_17180 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CDO84_17185 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) CDO84_17190 ENOG4105MKD CDO84_17195 ENOG4105DTJ flagellar hook-associated protein CDO84_17200 ENOG4105E1Q flagellar hook-associated protein CDO84_17215 ENOG4105RU3 CDO84_17220 ENOG41081UC Inherit from COG: Competence protein CDO84_17240 ENOG4105WH1 Two component transcriptional regulator luxr family CDO84_17245 ENOG4105BZU Histidine kinase CDO84_17250 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CDO84_17255 ENOG4108KGH TRANSCRIPTIONal CDO84_17260 ENOG4105ESV Glycosyl transferase, family 4 CDO84_17265 ENOG4107EF8 Glycosyl transferase (Group 1 CDO84_17280 ENOG4105QZI O-Antigen Polymerase CDO84_17285 ENOG4105C6Y Udp-glucose 6-dehydrogenase CDO84_17290 ENOG4107RA4 Glycosyl transferase (Group 1 CDO84_17295 ENOG4105PSV Polysaccharide Biosynthesis Protein CDO84_17300 ENOG4105D3Q Sugar transferase CDO84_17305 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CDO84_17310 ENOG4105JFG SpoIID LytB domain protein CDO84_17325 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CDO84_17330 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CDO84_17340 ENOG4107VDP teichoic acid biosynthesis CDO84_17345 ENOG41088M2 Glycosyl transferase family 2 CDO84_17365 ENOG4105EY8 ABC transporter CDO84_17375 ENOG4107SJB teichoic acid biosynthesis CDO84_17380 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) CDO84_17385 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase CDO84_17395 ENOG4107RZX Teichoic acid biosynthesis protein CDO84_17400 ENOG410651K Teichoic acid biosynthesis protein C CDO84_17410 ENOG4105DG6 mannose-6-phosphate isomerase CDO84_17425 ENOG4108NHD germination protein CDO84_17430 ENOG4105C54 Major Facilitator superfamily CDO84_17435 ENOG4108KGH TRANSCRIPTIONal CDO84_17440 ENOG4105J7I hydrolase CDO84_17445 ENOG4105K4H Nlp p60 protein CDO84_17455 ENOG4105PNM synthesis protein CDO84_17465 ENOG4105N98 Capsule biosynthesis protein capB CDO84_17470 ENOG4105ETE Transcriptional regulator (LacI family CDO84_17475 ENOG4108RVA ribokinase CDO84_17480 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CDO84_17485 ENOG4105C2J ABC transporter CDO84_17490 ENOG4105CNN ABC, transporter CDO84_17495 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CDO84_17510 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CDO84_17515 ENOG4107FQX Alpha-acetolactate decarboxylase CDO84_17525 ENOG4107RSM transcriptional regulator CDO84_17540 ENOG4106UIA CDO84_17555 ENOG4107XC4 flavin reductase domain protein, FMN-binding CDO84_17565 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CDO84_17575 ENOG4105CAH Chromate CDO84_17580 ENOG4105FGV Chromate CDO84_17590 ENOG4108WS4 fmn reductase CDO84_17595 ENOG4107V2S Transcriptional regulator CDO84_17600 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CDO84_17630 ENOG4108XI2 Domain of unknown function (DUF1963) CDO84_17635 ENOG4105C6Y Udp-glucose 6-dehydrogenase CDO84_17640 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CDO84_17645 ENOG4107YJ4 chain length determinant protein CDO84_17650 ENOG4105HTX biosynthesis protein CDO84_17660 ENOG4105KBK Zinc finger, swim domain protein CDO84_17665 ENOG4105C0D helicase CDO84_17670 ENOG410667J hydrolase CDO84_17675 ENOG4105E98 transcriptional regulator DeoR family CDO84_17680 ENOG4105Z8H single-stranded DNA-binding protein CDO84_17705 ENOG4108VAC response regulator CDO84_17715 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CDO84_17720 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CDO84_17730 ENOG4105CGA flagellar basal-body rod protein FlgG CDO84_17740 ENOG4105DFF Rod shape-determining protein mreb CDO84_17745 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CDO84_17755 ENOG4107MII Sugar-specific transcriptional regulator TrmB CDO84_17760 ENOG4105CZM Major Facilitator CDO84_17765 ENOG4108M26 parallel beta-helix repeat protein CDO84_17770 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CDO84_17775 ENOG41080V3 Major Facilitator superfamily CDO84_17780 ENOG4105D3W isochorismatase CDO84_17785 ENOG4107P26 CDO84_17790 ENOG4105BZU Histidine kinase CDO84_17800 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CDO84_17810 ENOG4105FRN stage II sporulation protein CDO84_17815 ENOG4107TCE N-acetyltransferase CDO84_17830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CDO84_17835 ENOG4107TXC Transcriptional regulator CDO84_17840 ENOG4106BRK CDO84_17845 ENOG4108RYK Nad-dependent epimerase dehydratase CDO84_17850 ENOG4108Z40 Transcriptional regulator CDO84_17855 ENOG4105CQM Urea amidohydrolase subunit alpha CDO84_17860 ENOG4105KI2 Urea amidohydrolase subunit beta CDO84_17865 ENOG4108YZ9 Urea amidohydrolase subunit gamma CDO84_17870 ENOG4108JJB ABC transporter CDO84_17900 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CDO84_17910 ENOG4108TF4 von Willebrand factor, type A CDO84_17920 ENOG4105JFG SpoIID LytB domain protein CDO84_17925 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CDO84_17935 ENOG4106778 Protein of unknown function (DUF1146) CDO84_17945 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CDO84_17950 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CDO84_17955 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CDO84_17960 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CDO84_17980 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) CDO84_17990 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CDO84_17995 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CDO84_18000 ENOG4108UIC UPF0340 protein CDO84_18005 ENOG4108YZG isomerase CDO84_18010 ENOG4107WAU Protein tyrosine phosphatase CDO84_18015 ENOG410815N Probably functions as a manganese efflux pump (By similarity) CDO84_18020 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CDO84_18030 ENOG4108ZXQ stage ii sporulation protein r CDO84_18045 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CDO84_18050 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CDO84_18055 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CDO84_18065 ENOG4107TT2 Auxin Efflux Carrier CDO84_18070 ENOG4105C6K Malic enzyme CDO84_18075 ENOG4107104 thymidine kinase CDO84_18080 ENOG41082DI 50s ribosomal protein l31 CDO84_18085 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CDO84_18090 ENOG4105CBT Fructose-1,6-bisphosphatase CDO84_18095 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CDO84_18100 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway CDO84_18105 ENOG4105D2N Aldolase CDO84_18110 ENOG410812K response regulator receiver protein CDO84_18120 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CDO84_18130 ENOG4105C1G acyl-Coa dehydrogenase CDO84_18135 ENOG4105DF6 Fe-S oxidoreductase CDO84_18145 ENOG4105E5J UV damage endonuclease CDO84_18155 ENOG4105NAE bifunctional deaminase-reductase domain protein CDO84_18160 ENOG4105BZ1 (ABC) transporter CDO84_18165 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CDO84_18180 ENOG4105R3A Nitrate reductase CDO84_18185 ENOG4108IUE nitrate reductase beta subunit CDO84_18205 ENOG4107V6Q Cyclic nucleotide-binding domain CDO84_18215 ENOG4105C75 arginyL-tRNA synthetase CDO84_18220 ENOG410684U Domain of unknown function (DUF1934) CDO84_18235 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E CDO84_18285 ENOG4107JM4 Tetratricopeptide repeat CDO84_18295 ENOG4108UIN ybak prolyl-trna synthetase associated region CDO84_18300 ENOG4105CYW agmatinase CDO84_18305 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CDO84_18310 ENOG4105BZ4 penicillin-binding protein CDO84_18320 ENOG4108XFG YwhD family CDO84_18325 ENOG4108Z4T Peptidase M50 CDO84_18330 ENOG41069HH 4-oxalocrotonate tautomerase CDO84_18335 ENOG41067TZ transcriptional regulator, MarR family CDO84_18340 ENOG4105C22 threonyL-tRNA synthetase CDO84_18350 ENOG4105C57 major facilitator superfamily CDO84_18355 ENOG41062ES Transcriptional regulator CDO84_18365 ENOG4105DCI Phosphohydrolase CDO84_18375 ENOG4108VCI transcription factor, rsfa family CDO84_18380 ENOG4108RNG Permease of the drug metabolite transporter CDO84_18385 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CDO84_18390 ENOG4105DUM transcriptional regulator, lysR family CDO84_18395 ENOG4108IJ2 phosphate acetyltransferase CDO84_18410 ENOG4105CHM Aminotransferase CDO84_18420 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase CDO84_18425 ENOG4105CHR reductase CDO84_18430 ENOG4106CHD Bacilysin biosynthesis protein bacB CDO84_18435 ENOG41061WN bacilysin biosynthesis protein CDO84_18440 ENOG4105FCW Major Facilitator superfamily CDO84_18455 ENOG4105C26 Dehydrogenase CDO84_18460 ENOG4105D82 Glutamate dehydrogenase CDO84_18470 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase CDO84_18475 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CDO84_18480 ENOG4105C1B dTDP-glucose 4-6-dehydratase CDO84_18485 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CDO84_18490 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG CDO84_18495 ENOG4107TY6 Acylneuraminate cytidylyltransferase CDO84_18505 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD CDO84_18510 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CDO84_18550 ENOG4105C26 Dehydrogenase CDO84_18555 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CDO84_18560 ENOG4108RJ9 Glycosyl transferase, family 2 CDO84_18580 ENOG4105DWF phosphomethylpyrimidine kinase CDO84_18595 ENOG4105C5Y PTS System CDO84_18600 ENOG4108QTI )-transporter CDO84_18615 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CDO84_18620 ENOG4105DEN Luciferase family CDO84_18625 ENOG4108DBC nitroreductase CDO84_18645 ENOG41060D1 Quinol oxidase CDO84_18650 ENOG4105CCU oxidase (Subunit III) CDO84_18655 ENOG4105BZ9 Cytochrome C oxidase, subunit I CDO84_18660 ENOG4105E2S oxidase) subunit II CDO84_18665 ENOG4107BMA Transglycosylase associated protein CDO84_18675 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CDO84_18680 ENOG4105WH5 Teichoic acid glycosylation protein CDO84_18705 ENOG4107ZXU DSBA oxidoreductase CDO84_18710 ENOG4105DBE peroxidase CDO84_18715 ENOG410650H (LipO)protein CDO84_18720 ENOG4107SJW iron permease, FTR1 CDO84_18725 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CDO84_18735 ENOG4105CMU LysR family (Transcriptional regulator CDO84_18740 ENOG4105VAW lrga family CDO84_18745 ENOG41067MG lrgb family CDO84_18750 ENOG4105D8G Major Facilitator superfamily CDO84_18760 ENOG4105DR4 Methyltransferase CDO84_18770 ENOG4108YV3 Protein of unknown function (DUF2711) CDO84_18775 ENOG4105CK1 PTS System CDO84_18785 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin CDO84_18805 ENOG4105X1N Glycosyl transferase family 8 CDO84_18815 ENOG4105GVJ transcriptional regulator CDO84_18820 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CDO84_18825 ENOG4105IIU Aminopeptidase CDO84_18850 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CDO84_18860 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) CDO84_18865 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CDO84_18875 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CDO84_18880 ENOG4108VHC Short-chain dehydrogenase reductase Sdr CDO84_18885 ENOG4105CM2 brancheD-chain amino acid aminotransferase CDO84_18890 ENOG4105F8D glycoside hydrolase family 4 CDO84_18895 ENOG4105VCP PTS System CDO84_18900 ENOG4105CK1 PTS System CDO84_18905 ENOG4105VZJ PTS System CDO84_18910 ENOG4105EMD TRANSCRIPTIONal CDO84_18920 ENOG4108VX5 3-methyladenine DNA glycosylase CDO84_18925 ENOG4105CH6 catalase CDO84_18940 ENOG4105DA5 (ABC) transporter CDO84_18945 ENOG41069JR CDO84_18965 ENOG4105ETS cytosine purines uracil thiamine allantoin CDO84_18970 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CDO84_18975 ENOG4108JJ8 (ABC) transporter CDO84_18980 ENOG4108JJ9 ABC, transporter CDO84_18985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CDO84_18990 ENOG4105C4M (Ubiquinol oxidase) subunit I CDO84_18995 ENOG4105D2K citrate carrier protein CDO84_19010 ENOG4107BJW polysaccharide deacetylase CDO84_19035 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CDO84_19045 ENOG4105CMR udp-glucose 4-epimerase CDO84_19055 ENOG4105BZU Histidine kinase CDO84_19060 ENOG4105WH1 Two component transcriptional regulator luxr family CDO84_19065 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CDO84_19090 ENOG4105DTD Dehydrogenase CDO84_19095 ENOG4108IIH CoA-transferase subunit B CDO84_19100 ENOG4105D6N CoA-transferase, subunit a CDO84_19105 ENOG4105CY2 Citrate transporter CDO84_19110 ENOG4105DHI Methyltransferase CDO84_19115 ENOG410904N short-chain dehydrogenase reductase CDO84_19135 ENOG4105CH6 catalase CDO84_19140 ENOG4105D4T Citrate transporter CDO84_19145 ENOG4108RZ2 Glycoside hydrolase family 16 CDO84_19150 ENOG4105CID antiterminator CDO84_19160 ENOG4105DEU major facilitator superfamily CDO84_19165 ENOG4105C1J atp-dependent rna helicase CDO84_19170 ENOG4107TDE lipolytic protein G-D-S-L family CDO84_19235 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CDO84_19245 ENOG4107YZX Universal stress protein CDO84_19250 ENOG4105CS2 ec 3.2.1.21 CDO84_19255 ENOG4105C5Y PTS System CDO84_19300 ENOG4107EV6 Inherit from COG: YD repeat protein CDO84_19315 ENOG4106Z5D Glycoside Hydrolase Family 43 CDO84_19330 ENOG4105C84 Histidine ammonia-lyase CDO84_19335 ENOG4105CGP Urocanate hydratase CDO84_19340 ENOG4105CI2 imidazolone-5-propionate hydrolase CDO84_19345 ENOG4107W25 arginase agmatinase formiminoglutamase CDO84_19355 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CDO84_19360 ENOG4105D9N nucleoside CDO84_19370 ENOG4107RHR regulatoR CDO84_19375 ENOG4108TM9 integral membrane protein CDO84_19380 ENOG4105ENY Ethanolamine utilization protein eutH CDO84_19385 ENOG4108PGP mmge prpd family protein CDO84_19390 ENOG4105CH2 amidohydrolase CDO84_19400 ENOG4108HW4 amino acid AbC transporter CDO84_19405 ENOG4105EAB amino acid AbC transporter CDO84_19410 ENOG4108XSB acetyltransferase, (GNAT) family CDO84_19415 ENOG4105CPU Monooxygenase CDO84_19420 ENOG4107QHE Choloylglycine hydrolase CDO84_19425 ENOG410667J hydrolase CDO84_19455 ENOG4108V5C ABC transporter CDO84_19485 ENOG4105D2N Aldolase CDO84_19490 ENOG4107TRN Xylose isomerase domain protein TIM barrel CDO84_19495 ENOG4105F0H myo-inositol catabolism protein CDO84_19500 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CDO84_19510 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CDO84_19515 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CDO84_19520 ENOG4105D7K pfkb domain protein CDO84_19530 ENOG4105C26 Dehydrogenase CDO84_19540 ENOG4105CPC Aldo Keto reductase CDO84_19570 ENOG4107QNK )-transporter CDO84_19575 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CDO84_19585 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CDO84_19615 ENOG4105ST3 Transcriptional regulator CDO84_19620 ENOG4105C26 Dehydrogenase CDO84_19625 ENOG41085PJ rdd domain containing protein CDO84_19630 ENOG4108ITS PQQ enzyme repeat CDO84_19640 ENOG41085PJ rdd domain containing protein CDO84_19655 ENOG4105J7D transcriptional regulator CDO84_19660 ENOG4107JEE Short-chain dehydrogenase reductase Sdr CDO84_19665 ENOG41061AU MarR family Transcriptional regulator CDO84_19675 ENOG41067MG lrgb family CDO84_19690 ENOG4105BZW Glycerate kinase CDO84_19695 ENOG4105G3Z GntR family transcriptional regulator CDO84_19700 ENOG4105CMG Carbohydrate kinase CDO84_19705 ENOG4105C6Z Gluconate CDO84_19710 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CDO84_19715 ENOG4105D3R alkyl hydroperoxide reductase CDO84_19720 ENOG4108JU3 Alkyl hydroperoxide reductase CDO84_19725 ENOG4105CS2 ec 3.2.1.21 CDO84_19735 ENOG4105C5Y PTS System CDO84_19740 ENOG4108S3Y transcriptional regulator CDO84_19750 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 CDO84_19765 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CDO84_19780 ENOG4105E2A Dehydrogenase CDO84_19800 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) CDO84_19805 ENOG4105WQG acetyltransferase CDO84_19810 ENOG410780I phosphoprotein phosphatase activity CDO84_19820 ENOG41066UZ arginase EC 3.5.3.1 CDO84_19825 ENOG4108IQI permease CDO84_19830 ENOG4105C8Y Acetylornithine aminotransferase CDO84_19860 ENOG41082BM Transcriptional regulator, arsr family CDO84_19865 ENOG4108JUB Transcriptional regulator CDO84_19870 ENOG4105BZU Histidine kinase CDO84_19885 ENOG4105C0H protease CDO84_19890 ENOG4105Q2H domain protein CDO84_19905 ENOG4105BZU Histidine kinase CDO84_19910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDO84_19935 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CDO84_19940 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CDO84_19945 ENOG4105CDU Replicative dna helicase CDO84_19965 ENOG4105DJ2 Major Facilitator Superfamily CDO84_19970 ENOG4105EDW glycosyl transferase, family 39 CDO84_19975 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CDO84_19980 ENOG4105BZR domain protein CDO84_19985 ENOG4108XMW Membrane CDO84_20000 ENOG4105KVH Transcriptional regulator CDO84_20005 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase CDO84_20040 ENOG4105VN1 Heat shock protein CDO84_20055 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein CDO84_20060 ENOG4105DDN Pentapeptide repeat-containing protein CDO84_20065 ENOG4105D94 Major Facilitator Superfamily CDO84_20070 ENOG4107RSM transcriptional regulator CDO84_20075 ENOG41082BV acetyltransferase CDO84_20080 ENOG41081I9 integral membrane protein CDO84_20090 ENOG4108U05 Transcriptional regulator CDO84_20095 ENOG41082BV acetyltransferase CDO84_20105 ENOG4108U7W acetyltransferase CDO84_20110 ENOG4105UNS Pfam:DUF419 CDO84_20115 ENOG4105NAE bifunctional deaminase-reductase domain protein CDO84_20125 ENOG4108J8C transporter major facilitator family protein CDO84_20140 ENOG4108IPJ Membrane CDO84_20145 ENOG4105C7Z Conserved Protein CDO84_20150 ENOG4107FCW Abortive infection protein CDO84_20160 ENOG4108UW5 maltose o-acetyltransferase CDO84_20165 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CDO84_20175 ENOG4105CGK Exodeoxyribonuclease III CDO84_20180 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CDO84_20185 ENOG4108UUM single-stranded DNA-binding protein CDO84_20190 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CDO84_20195 ENOG4105C3G gtp-binding protein CDO84_20200 ENOG4108J2R molybdopterin oxidoreductase CDO84_20205 ENOG4105VDK protein, conserved in bacteria CDO84_20215 ENOG4108ZDA Sporulation protein YyaC CDO84_20220 ENOG4105FA0 parb-like partition protein CDO84_20225 ENOG4107QJE Chromosome Partitioning Protein CDO84_20240 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CDO84_20245 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CDO84_20250 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CDO84_20265 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CDO84_20275 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CDO84_20280 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CDO84_20285 ENOG410848D S4 domain protein YaaA CDO84_20300 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CDO84_20305 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CDO84_20340 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CDO84_20350 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CDO84_20355 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CDO84_20360 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CDO84_20370 ENOG4105ZMH deoxynucleoside kinase CDO84_20380 ENOG4105VRS hydrolase family 18 CDO84_20385 ENOG4105GTG Isochorismatase CDO84_20390 ENOG4108Z6B deaminase CDO84_20400 ENOG4105C6E dna polymerase iii CDO84_20405 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CDO84_20410 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CDO84_20420 ENOG41067KS pro-sigma K processing CDO84_20460 ENOG4105CDW Resistance protein CDO84_20465 ENOG4105CXN decarboxylase CDO84_20470 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CDO84_20475 ENOG4105X0R protein from nitrogen regulatory protein P-II CDO84_20480 ENOG4105XVJ Protein of unknown function (DUF327) CDO84_20485 ENOG4105FA2 dna polymerase iii CDO84_20490 ENOG4105MA4 psp1 domain protein CDO84_20495 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) CDO84_20500 ENOG41060K3 Methyltransferase CDO84_20505 ENOG4105VC4 domain protein CDO84_20510 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CDO84_20515 ENOG4105KRN Transcriptional regulator, abrb family CDO84_20520 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CDO84_20525 ENOG4105F8V Hydrolase, tatD family CDO84_20530 ENOG41069ER domain protein CDO84_20540 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CDO84_20550 ENOG4105XFA sporulation peptidase YabG CDO84_20555 ENOG4105W42 Veg protein CDO84_20560 ENOG4105XEW small acid-soluble spore protein CDO84_20565 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CDO84_20570 ENOG4105DFT pur operon repressor CDO84_20575 ENOG4105KME endoribonuclease L-psp CDO84_20580 ENOG4105K4W Could be involved in septation (By similarity) CDO84_20585 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CDO84_20590 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CDO84_20595 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CDO84_20600 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CDO84_20610 ENOG4108JA2 transcriptioN-repair coupling factor CDO84_20615 ENOG4108M14 stage v sporulation protein t CDO84_20625 ENOG4108IY2 MazG family CDO84_20630 ENOG41082I2 s4 domain protein CDO84_20635 ENOG4105VYY sporulation protein yabp CDO84_20650 ENOG41060GV RNA binding s1 domain protein CDO84_20680 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CDO84_20685 ENOG4108UGV hypoxanthine phosphoribosyltransferase CDO84_20690 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CDO84_20700 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CDO84_20705 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase CDO84_20710 ENOG4105C6T cysteine synthase CDO84_20715 ENOG4105CRQ synthase (Component I) CDO84_20720 ENOG4105DDQ anthranilate synthase CDO84_20725 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CDO84_20730 ENOG4105EEI dihydropteroate synthase CDO84_20735 ENOG4105KRF dihydroneopterin aldolase CDO84_20740 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CDO84_20750 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CDO84_20755 ENOG4105CRK lysyL-tRNA synthetase CDO84_20845 ENOG4108Z0C Uvrb UvrC protein CDO84_20850 ENOG41066A3 ATP guanido phosphotransferase CDO84_20860 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CDO84_20865 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CDO84_20870 ENOG4105CTP PilT protein domain protein CDO84_20875 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CDO84_20880 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CDO84_20885 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CDO84_20890 ENOG4105D7W serine acetyltransferase CDO84_20895 ENOG4105C8N cysteinyl-tRNA synthetase CDO84_20900 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CDO84_20905 ENOG4105C2N RNA methyltransferase TrmH family group 3 CDO84_20910 ENOG4105M0M Tetracycline resistance protein CDO84_20930 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CDO84_20935 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CDO84_20945 ENOG4108VZM 50s ribosomal protein L10 CDO84_20950 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CDO84_20955 ENOG4107Y49 methyltransferase CDO84_20960 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CDO84_20965 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CDO84_20970 ENOG4105XPM ribosomal protein CDO84_20975 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CDO84_20980 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CDO84_20985 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CDO84_20990 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CDO84_20995 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CDO84_21000 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CDO84_21005 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CDO84_21010 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CDO84_21015 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CDO84_21020 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CDO84_21025 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CDO84_21030 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CDO84_21035 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CDO84_21040 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CDO84_21045 ENOG41082SA 50s ribosomal protein l29 CDO84_21050 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CDO84_21055 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CDO84_21065 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CDO84_21075 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CDO84_21080 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CDO84_21085 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CDO84_21090 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CDO84_21095 ENOG4105VPB 50S ribosomal protein L30 CDO84_21100 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CDO84_21105 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CDO84_21115 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CDO84_21125 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CDO84_21135 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CDO84_21140 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CDO84_21145 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CDO84_21150 ENOG4108ZT0 50S ribosomal protein l17 CDO84_21155 ENOG4108JJB ABC transporter CDO84_21160 ENOG4108JJB ABC transporter CDO84_21165 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CDO84_21170 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CDO84_21175 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CDO84_21180 ENOG4108UJD 30S ribosomal protein S9 CDO84_21185 ENOG4108I0C methyltransferase CDO84_21200 ENOG4105D1F ATP-binding protein CDO84_21215 ENOG4108NMV polysaccharide deacetylase