locus-tag	class	description
MAK48_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MAK48_00010	COG0592	DNA-directed DNA polymerase activity
MAK48_00015	COG2501	S4 domain
MAK48_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MAK48_00030	COG0187	DNA topoisomerase II activity
MAK48_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAK48_00070	COG0516	GMP reductase activity
MAK48_00070	COG0517	IMP dehydrogenase activity
MAK48_00075	COG1686	Belongs to the peptidase S11 family
MAK48_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MAK48_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MAK48_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MAK48_00100	COG1428	Deoxynucleoside kinase
MAK48_00105	COG1428	Deoxynucleoside kinase
MAK48_00110	COG1388	LysM domain
MAK48_00110	COG3858	chitin binding
MAK48_00115	COG1335	isochorismatase
MAK48_00120	COG0590	tRNA wobble adenosine to inosine editing
MAK48_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MAK48_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MAK48_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MAK48_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
MAK48_00190	COG3853	Toxic anion resistance protein (TelA)
MAK48_00195	COG1982	Orn Lys Arg decarboxylase major
MAK48_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MAK48_00205	COG3870	Protein conserved in bacteria
MAK48_00210	COG1728	Protein conserved in bacteria
MAK48_00215	COG0470	DNA polymerase III
MAK48_00220	COG1774	PSP1 C-terminal conserved region
MAK48_00225	COG4467	Involved in initiation control of chromosome replication
MAK48_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MAK48_00235	COG2827	Endonuclease containing a URI domain
MAK48_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MAK48_00245	COG2002	toxin-antitoxin pair type II binding
MAK48_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAK48_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAK48_00255	COG0084	hydrolase, TatD family'
MAK48_00260	COG3584	3D domain protein
MAK48_00260	COG3583	domain protein
MAK48_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MAK48_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MAK48_00280	COG4466	Protein conserved in bacteria
MAK48_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MAK48_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAK48_00300	COG0251	oxidation-reduction process
MAK48_00305	COG2088	sporulation resulting in formation of a cellular spore
MAK48_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MAK48_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MAK48_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MAK48_00325	COG0193	aminoacyl-tRNA hydrolase activity
MAK48_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MAK48_00340	COG2002	toxin-antitoxin pair type II binding
MAK48_00345	COG2244	polysaccharide biosynthetic process
MAK48_00350	COG3956	TIGRFAM MazG family protein
MAK48_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MAK48_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MAK48_00375	COG1098	S1 RNA binding domain
MAK48_00390	COG2208	phosphoserine phosphatase activity
MAK48_00395	COG2304	oxidoreductase activity
MAK48_00400	COG0515	serine threonine protein kinase
MAK48_00405	COG0037	tRNA processing
MAK48_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MAK48_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAK48_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MAK48_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MAK48_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MAK48_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MAK48_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MAK48_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
MAK48_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAK48_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MAK48_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MAK48_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MAK48_00470	COG1396	sequence-specific DNA binding
MAK48_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MAK48_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MAK48_00560	COG4463	regulation of RNA biosynthetic process
MAK48_00565	COG3880	PFAM UvrB UvrC protein
MAK48_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MAK48_00575	COG0542	response to heat
MAK48_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MAK48_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MAK48_00590	COG4956	integral membrane protein (PIN domain superfamily)
MAK48_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MAK48_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MAK48_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MAK48_00610	COG1045	serine acetyltransferase
MAK48_00615	COG0215	cysteine-tRNA ligase activity
MAK48_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MAK48_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAK48_00630	COG3688	RNA-binding protein containing a PIN domain
MAK48_00635	COG1595	DNA-templated transcription, initiation
MAK48_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MAK48_00650	COG0250	Participates in transcription elongation, termination and antitermination
MAK48_00660	COG0081	regulation of translation
MAK48_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MAK48_00675	COG2813	Specifically methylates the guanine in position
MAK48_00680	COG0085	RNA polymerase activity
MAK48_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MAK48_00690	COG1358	cellular component organization or biogenesis
MAK48_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MAK48_00700	COG0049	tRNA binding
MAK48_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MAK48_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MAK48_00715	COG0596	Alpha beta hydrolase
MAK48_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MAK48_00730	COG0088	Forms part of the polypeptide exit tunnel
MAK48_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MAK48_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MAK48_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MAK48_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MAK48_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MAK48_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MAK48_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MAK48_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MAK48_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MAK48_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MAK48_00820	COG0200	Binds to the 23S rRNA
MAK48_00825	COG0201	protein transport
MAK48_00830	COG0563	adenylate kinase activity
MAK48_00835	COG0024	Methionine aminopeptidase
MAK48_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
MAK48_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MAK48_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MAK48_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MAK48_00865	COG0202	RNA polymerase activity
MAK48_00870	COG0203	ribosomal protein L17
MAK48_00875	COG1122	ATPase activity
MAK48_00880	COG1122	ATPase activity
MAK48_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MAK48_00890	COG0101	tRNA pseudouridine synthase activity
MAK48_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MAK48_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MAK48_00905	COG2226	methyltransferase
MAK48_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAK48_00920	COG0489	protein tyrosine kinase activity
MAK48_00930	COG2194	sulfuric ester hydrolase activity
MAK48_00935	COG0726	polysaccharide deacetylase
MAK48_01015	COG0659	secondary active sulfate transmembrane transporter activity
MAK48_01020	COG0385	Bile acid
MAK48_01025	COG2819	hydrolase of the alpha beta superfamily
MAK48_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MAK48_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MAK48_01045	COG2207	Transcriptional regulator
MAK48_01050	COG3876	Protein conserved in bacteria
MAK48_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
MAK48_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MAK48_01065	COG1263	PTS System
MAK48_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_01070	COG1737	Transcriptional regulator
MAK48_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MAK48_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_01085	COG1683	Conserved Protein
MAK48_01115	COG1595	DNA-templated transcription, initiation
MAK48_01120	COG5662	AntiSigma factor
MAK48_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MAK48_01130	COG4856	YbbR-like protein
MAK48_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAK48_01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MAK48_01150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MAK48_01155	COG2169	Transcriptional regulator
MAK48_01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MAK48_01165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MAK48_01170	COG3002	Belongs to the UPF0753 family
MAK48_01175	COG0288	reversible hydration of carbon dioxide
MAK48_01185	COG5609	conserved protein (DUF2294)
MAK48_01190	COG0640	Transcriptional regulator
MAK48_01195	COG2814	Major facilitator Superfamily
MAK48_01210	COG0535	radical SAM domain protein
MAK48_01215	COG1266	CAAX protease self-immunity
MAK48_01220	COG1131	(ABC) transporter
MAK48_01230	COG1413	lyase activity
MAK48_01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_01240	COG0596	Alpha beta hydrolase
MAK48_01245	COG0745	RESPONSE REGULATOR receiver
MAK48_01250	COG0642	Histidine kinase
MAK48_01260	COG0515	serine threonine protein kinase
MAK48_01275	COG1113	amino acid transport
MAK48_01290	COG2602	Beta-lactamase
MAK48_01295	COG2124	cytochrome p450
MAK48_01305	COG0531	amino acid
MAK48_01310	COG0584	glycerophosphoryl diester phosphodiesterase
MAK48_01315	COG2271	Major facilitator Superfamily
MAK48_01325	COG0456	acetyltransferase
MAK48_01325	COG1846	Transcriptional regulator
MAK48_01330	COG2271	Major facilitator Superfamily
MAK48_01340	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_01345	COG0697	spore germination
MAK48_01350	COG1917	Cupin 2, conserved barrel domain protein
MAK48_01350	COG2207	Transcriptional regulator
MAK48_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MAK48_01360	COG3591	Belongs to the peptidase S1B family
MAK48_01370	COG0596	Alpha beta hydrolase
MAK48_01375	COG1183	phosphatidylcholine synthase activity
MAK48_01380	COG0586	Pfam SNARE associated Golgi protein
MAK48_01385	COG0688	phosphatidylethanolamine metabolic process
MAK48_01395	COG2312	Erythromycin esterase
MAK48_01400	COG2207	Transcriptional regulator
MAK48_01405	COG1054	Belongs to the UPF0176 family
MAK48_01410	COG1301	dicarboxylic acid transport
MAK48_01415	COG1263	PTS System
MAK48_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_01415	COG2190	(PTS) system
MAK48_01420	COG0363	glucosamine-6-phosphate deaminase activity
MAK48_01425	COG2188	Transcriptional regulator
MAK48_01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAK48_01440	COG0833	amino acid
MAK48_01445	COG2040	homocysteine
MAK48_01450	COG1115	amino acid carrier protein
MAK48_01455	COG2066	Belongs to the glutaminase family
MAK48_01460	COG4191	Histidine kinase
MAK48_01465	COG0784	Response regulator, receiver
MAK48_01470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MAK48_01475	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_01480	COG2271	Major facilitator Superfamily
MAK48_01485	COG4948	Mandelate Racemase Muconate Lactonizing
MAK48_01490	COG2186	Transcriptional regulator
MAK48_01495	COG2721	sulfolactate sulfo-lyase activity
MAK48_01500	COG3173	Aminoglycoside phosphotransferase
MAK48_01510	COG0697	spore germination
MAK48_01515	COG0745	RESPONSE REGULATOR receiver
MAK48_01520	COG2205	protein histidine kinase activity
MAK48_01525	COG1131	(ABC) transporter
MAK48_01545	COG3773	Cell wall hydrolase
MAK48_01550	COG2304	oxidoreductase activity
MAK48_01560	COG3540	Alkaline phosphatase
MAK48_01565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MAK48_01570	COG0805	protein transport
MAK48_01575	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MAK48_01580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MAK48_01585	COG0477	Major facilitator Superfamily
MAK48_01590	COG1309	transcriptional regulator
MAK48_01595	COG0252	asparaginase activity
MAK48_01600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MAK48_01605	COG1714	RDD family
MAK48_01610	COG1405	negative regulation of cell septum assembly
MAK48_01610	COG3012	SEC-C Motif Domain Protein
MAK48_01615	COG3290	protein histidine kinase activity
MAK48_01620	COG3279	Response regulator of the LytR AlgR family
MAK48_01625	COG4555	ABC transporter
MAK48_01630	COG1668	transmembrane transport
MAK48_01635	COG0667	Aldo Keto reductase
MAK48_01650	COG1595	DNA-templated transcription, initiation
MAK48_01655	COG1595	DNA-templated transcription, initiation
MAK48_01660	COG1876	peptidase activity
MAK48_01665	COG0457	Tetratricopeptide repeat
MAK48_01670	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_01675	COG0366	Alpha amylase catalytic
MAK48_01680	COG0803	Belongs to the bacterial solute-binding protein 9 family
MAK48_01685	COG1121	(ABC) transporter
MAK48_01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MAK48_01695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_01700	COG2310	stress, protein
MAK48_01705	COG2310	stress, protein
MAK48_01710	COG2310	stress, protein
MAK48_01715	COG0861	Integral membrane protein TerC family
MAK48_01725	COG3853	Toxic anion resistance protein (TelA)
MAK48_01730	COG0477	Major facilitator Superfamily
MAK48_01735	COG2814	Major facilitator Superfamily
MAK48_01740	COG0640	Transcriptional regulator
MAK48_01745	COG0517	IMP dehydrogenase activity
MAK48_01745	COG4175	Glycine betaine
MAK48_01750	COG4176	ABC-type proline glycine betaine transport system permease component
MAK48_01755	COG2113	Glycine betaine
MAK48_01760	COG1473	amidohydrolase
MAK48_01765	COG1288	antiporter activity
MAK48_01775	COG0366	Alpha amylase catalytic
MAK48_01780	COG0039	L-malate dehydrogenase activity
MAK48_01785	COG1620	l-lactate permease
MAK48_01790	COG2814	Major facilitator Superfamily
MAK48_01795	COG1846	Transcriptional regulator
MAK48_01800	COG1280	lysine exporter protein (LysE YggA)
MAK48_01805	COG3403	YqcI/YcgG family
MAK48_01810	COG1113	amino acid transport
MAK48_01815	COG3665	Urea carboxylase-associated protein
MAK48_01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MAK48_01825	COG1660	Displays ATPase and GTPase activities
MAK48_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MAK48_01835	COG2226	methyltransferase
MAK48_01840	COG0583	DNA-binding transcription factor activity
MAK48_01845	COG3458	cephalosporin-C deacetylase activity
MAK48_01850	COG3541	Predicted nucleotidyltransferase
MAK48_01855	COG0506	proline dehydrogenase activity
MAK48_01860	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_01865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MAK48_01870	COG2508	Transcriptional regulator
MAK48_01875	COG3689	TIGRFAM TIGR03943 family protein
MAK48_01880	COG0701	Predicted permease
MAK48_01885	COG2267	carboxylic ester hydrolase activity
MAK48_01890	COG0492	ferredoxin-NADP+ reductase activity
MAK48_01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MAK48_01895	COG1587	Uroporphyrinogen-III synthase
MAK48_01900	COG2146	nitrite reductase [NAD(P)H] activity
MAK48_01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MAK48_01910	COG0243	molybdopterin cofactor binding
MAK48_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MAK48_01920	COG2223	nitrite transmembrane transporter activity
MAK48_01925	COG1469	GTP cyclohydrolase I activity
MAK48_01930	COG1376	ErfK ybiS ycfS ynhG family protein
MAK48_01945	COG0523	cobalamin synthesis protein
MAK48_01950	COG0765	amino acid transport
MAK48_01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAK48_01975	COG2723	6-phospho-beta-galactosidase activity
MAK48_01985	COG3209	COG3209 Rhs family protein
MAK48_01990	COG0840	transmembrane signaling receptor activity
MAK48_01990	COG3290	protein histidine kinase activity
MAK48_01995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MAK48_02000	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MAK48_02005	COG1733	regulation of RNA biosynthetic process
MAK48_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_02040	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
MAK48_02045	COG2814	Major facilitator Superfamily
MAK48_02055	COG0697	spore germination
MAK48_02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAK48_02070	COG2364	Membrane
MAK48_02075	COG1126	abc transporter atp-binding protein
MAK48_02080	COG0765	amino acid transport
MAK48_02085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAK48_02090	COG0583	DNA-binding transcription factor activity
MAK48_02095	COG0163	prenyltransferase activity
MAK48_02100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MAK48_02115	COG0596	Alpha beta hydrolase
MAK48_02120	COG3104	oligopeptide transport
MAK48_02125	COG5434	Belongs to the glycosyl hydrolase 28 family
MAK48_02135	COG0697	spore germination
MAK48_02145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MAK48_02150	COG1136	(ABC) transporter
MAK48_02155	COG0577	efflux transmembrane transporter activity
MAK48_02160	COG0745	RESPONSE REGULATOR receiver
MAK48_02165	COG3850	Histidine kinase
MAK48_02165	COG5002	protein histidine kinase activity
MAK48_02170	COG0457	Tetratricopeptide repeat
MAK48_02190	COG0527	aspartate kinase activity
MAK48_02195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_02200	COG4605	iron ion homeostasis
MAK48_02205	COG4604	ABC transporter, ATP-binding protein
MAK48_02210	COG4607	ABC-type enterochelin transport system periplasmic component
MAK48_02215	COG2814	Major facilitator Superfamily
MAK48_02220	COG1309	transcriptional regulator
MAK48_02225	COG0778	Nitroreductase
MAK48_02230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MAK48_02235	COG0640	Transcriptional regulator
MAK48_02240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAK48_02245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MAK48_02250	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_02255	COG4975	Glucose uptake
MAK48_02260	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_02265	COG4549	nuclear export factor GLE1
MAK48_02270	COG1276	copper resistance
MAK48_02270	COG2372	response to copper ion
MAK48_02275	COG1349	DNA-binding transcription factor activity
MAK48_02285	COG2213	PTS system mannitol-specific
MAK48_02290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_02295	COG0246	Mannitol dehydrogenase
MAK48_02300	COG0473	3-isopropylmalate dehydrogenase activity
MAK48_02305	COG0681	Belongs to the peptidase S26 family
MAK48_02310	COG0412	Dienelactone hydrolase
MAK48_02315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MAK48_02325	COG0561	phosphatase activity
MAK48_02330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MAK48_02335	COG1914	H( )-stimulated, divalent metal cation uptake system
MAK48_02340	COG4336	lyase activity
MAK48_02345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MAK48_02350	COG1984	allophanate hydrolase subunit 2
MAK48_02355	COG1414	Transcriptional regulator
MAK48_02360	COG2755	lipolytic protein G-D-S-L family
MAK48_02370	COG2329	Antibiotic biosynthesis monooxygenase
MAK48_02375	COG0768	penicillin binding
MAK48_02380	COG4989	oxidoreductase activity
MAK48_02385	COG3711	transcriptional antiterminator
MAK48_02390	COG0318	PFAM AMP-dependent synthetase and ligase
MAK48_02395	COG2226	methyltransferase
MAK48_02400	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_02405	COG1917	Cupin 2, conserved barrel domain protein
MAK48_02410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_02415	COG3871	stress protein (general stress protein 26)
MAK48_02425	COG2814	Major facilitator Superfamily
MAK48_02430	COG1522	sequence-specific DNA binding
MAK48_02435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MAK48_02435	COG0551	DNA topoisomerase type I activity
MAK48_02440	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MAK48_02445	COG3706	GGDEF domain
MAK48_02450	COG5298	Protein conserved in bacteria
MAK48_02455	COG1215	transferase activity, transferring glycosyl groups
MAK48_02465	COG0531	amino acid
MAK48_02470	COG0494	nUDIX hydrolase
MAK48_02475	COG0028	Belongs to the TPP enzyme family
MAK48_02490	COG1914	H( )-stimulated, divalent metal cation uptake system
MAK48_02495	COG2261	transglycosylase associated protein
MAK48_02500	COG4876	unkown
MAK48_02505	COG2217	Heavy metal translocating P-type atpase
MAK48_02510	COG3729	General stress protein
MAK48_02515	COG0662	Cupin 2, conserved barrel domain protein
MAK48_02520	COG2329	Antibiotic biosynthesis monooxygenase
MAK48_02525	COG3546	catalase activity
MAK48_02530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MAK48_02535	COG3290	protein histidine kinase activity
MAK48_02540	COG4565	transcriptional regulatory protein
MAK48_02545	COG1301	dicarboxylic acid transport
MAK48_02550	COG0628	permease
MAK48_02555	COG1131	(ABC) transporter
MAK48_02560	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MAK48_02570	COG1960	acyl-CoA dehydrogenase activity
MAK48_02585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MAK48_02590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_02595	COG1181	Belongs to the D-alanine--D-alanine ligase family
MAK48_02600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MAK48_02605	COG0513	Belongs to the DEAD box helicase family
MAK48_02610	COG3402	PFAM membrane-flanked domain
MAK48_02615	COG3428	Bacterial PH domain
MAK48_02620	COG0705	Rhomboid family
MAK48_02625	COG0736	holo-[acyl-carrier-protein] synthase activity
MAK48_02630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MAK48_02635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MAK48_02640	COG0864	Transcriptional regulator
MAK48_02645	COG2337	Toxic component of a toxin-antitoxin (TA) module
MAK48_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_02655	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_02660	COG2172	sigma factor antagonist activity
MAK48_02665	COG2208	phosphoserine phosphatase activity
MAK48_02670	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_02675	COG2172	sigma factor antagonist activity
MAK48_02680	COG1191	sigma factor activity
MAK48_02685	COG2208	phosphoserine phosphatase activity
MAK48_02705	COG1673	EVE domain
MAK48_02710	COG1846	Transcriptional regulator
MAK48_02715	COG2183	response to ionizing radiation
MAK48_02725	COG3091	SprT-like family
MAK48_02765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_02770	COG1522	sequence-specific DNA binding
MAK48_02775	COG1522	sequence-specific DNA binding
MAK48_02780	COG1335	isochorismatase
MAK48_02785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MAK48_02790	COG2814	Major facilitator Superfamily
MAK48_02815	COG1278	Cold shock
MAK48_02820	COG1329	Transcriptional regulator
MAK48_02835	COG1917	Cupin 2, conserved barrel domain protein
MAK48_02835	COG2207	Transcriptional regulator
MAK48_02840	COG0697	spore germination
MAK48_02845	COG2207	Transcriptional regulator
MAK48_02845	COG3708	Transcriptional regulator
MAK48_02850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAK48_02855	COG0477	Major facilitator Superfamily
MAK48_02865	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MAK48_02875	COG0697	spore germination
MAK48_02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAK48_02885	COG2030	dehydratase
MAK48_02890	COG3545	Serine hydrolase
MAK48_02895	COG1733	regulation of RNA biosynthetic process
MAK48_02900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MAK48_02905	COG1733	regulation of RNA biosynthetic process
MAK48_02910	COG2249	NAD(P)H dehydrogenase (quinone) activity
MAK48_02915	COG2814	Major facilitator Superfamily
MAK48_02920	COG1309	transcriptional regulator
MAK48_02925	COG0640	Transcriptional regulator
MAK48_02930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MAK48_02940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_02945	COG0697	spore germination
MAK48_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAK48_02955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MAK48_02960	COG0640	Transcriptional regulator
MAK48_02965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAK48_02980	COG4585	Histidine kinase
MAK48_02985	COG2197	response regulator
MAK48_02990	COG2409	Drug exporters of the RND superfamily
MAK48_02995	COG0596	Alpha beta hydrolase
MAK48_03000	COG1811	Na channel or pump
MAK48_03005	COG0789	Transcriptional regulator
MAK48_03005	COG4978	Transcriptional regulator
MAK48_03010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MAK48_03015	COG0778	Nitroreductase
MAK48_03020	COG0346	lactoylglutathione lyase activity
MAK48_03025	COG2259	Doxx family
MAK48_03030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_03050	COG2323	membrane
MAK48_03055	COG2323	membrane
MAK48_03060	COG0071	Belongs to the small heat shock protein (HSP20) family
MAK48_03075	COG1309	transcriptional regulator
MAK48_03085	COG0456	acetyltransferase
MAK48_03090	COG0488	(ABC) transporter
MAK48_03095	COG1113	amino acid transport
MAK48_03100	COG2318	DinB family
MAK48_03105	COG1846	Transcriptional regulator
MAK48_03110	COG1033	growth of symbiont in host cell
MAK48_03110	COG2409	Drug exporters of the RND superfamily
MAK48_03115	COG0778	Nitroreductase
MAK48_03120	COG1846	Transcriptional regulator
MAK48_03125	COG2814	Major facilitator Superfamily
MAK48_03130	COG0730	response to heat
MAK48_03135	COG1802	Transcriptional regulator
MAK48_03140	COG3858	chitin binding
MAK48_03140	COG1388	LysM domain
MAK48_03145	COG1819	glycosyl
MAK48_03155	COG1785	Belongs to the alkaline phosphatase family
MAK48_03160	COG5646	InterPro IPR014922
MAK48_03170	COG0454	-acetyltransferase
MAK48_03175	COG1078	dGTPase activity
MAK48_03180	COG1388	LysM domain
MAK48_03185	COG2814	Major facilitator Superfamily
MAK48_03190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MAK48_03195	COG1447	Phosphotransferase system cellobiose-specific component IIA
MAK48_03200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MAK48_03205	COG2723	6-phospho-beta-galactosidase activity
MAK48_03210	COG2188	Transcriptional regulator
MAK48_03215	COG1940	carbohydrate kinase activity
MAK48_03220	COG1482	cell wall glycoprotein biosynthetic process
MAK48_03225	COG4124	Belongs to the glycosyl hydrolase 26 family
MAK48_03270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MAK48_03275	COG0802	atpase or kinase
MAK48_03280	COG1214	PFAM Peptidase M22, glycoprotease
MAK48_03285	COG0456	acetyltransferase
MAK48_03290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MAK48_03295	COG0488	(ABC) transporter
MAK48_03300	COG0315	cyclic pyranopterin monophosphate synthase activity
MAK48_03305	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MAK48_03310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MAK48_03315	COG0805	protein transport
MAK48_03325	COG1266	CAAX protease self-immunity
MAK48_03335	COG0459	protein refolding
MAK48_03365	COG0270	DNA (cytosine-5-)-methyltransferase activity
MAK48_03370	COG0270	DNA (cytosine-5-)-methyltransferase activity
MAK48_03385	COG1401	restriction endodeoxyribonuclease activity
MAK48_03405	COG0457	Tetratricopeptide repeat
MAK48_03410	COG1063	alcohol dehydrogenase
MAK48_03415	COG2211	Major facilitator Superfamily
MAK48_03420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAK48_03425	COG1842	Phage shock protein A
MAK48_03430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MAK48_03435	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MAK48_03440	COG4260	virion core protein, lumpy skin disease virus
MAK48_03450	COG2814	Major facilitator Superfamily
MAK48_03455	COG1063	alcohol dehydrogenase
MAK48_03460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MAK48_03465	COG0823	Involved in the tonB-independent uptake of proteins
MAK48_03480	COG2267	carboxylic ester hydrolase activity
MAK48_03490	COG2132	Multicopper oxidase
MAK48_03495	COG1113	amino acid transport
MAK48_03505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MAK48_03510	COG0714	Associated with various cellular activities
MAK48_03515	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MAK48_03520	COG1305	Transglutaminase-like
MAK48_03525	COG0519	Catalyzes the synthesis of GMP from XMP
MAK48_03525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MAK48_03530	COG2252	PERMEase
MAK48_03535	COG3064	Membrane
MAK48_03545	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MAK48_03555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MAK48_03560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MAK48_03565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MAK48_03570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MAK48_03575	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAK48_03580	COG0047	phosphoribosylformylglycinamidine synthase activity
MAK48_03585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MAK48_03590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MAK48_03595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MAK48_03600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MAK48_03605	COG0138	bifunctional purine biosynthesis protein purh
MAK48_03610	COG0151	Belongs to the GarS family
MAK48_03615	COG1522	sequence-specific DNA binding
MAK48_03620	COG0531	amino acid
MAK48_03630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MAK48_03635	COG1470	cell adhesion involved in biofilm formation
MAK48_03640	COG4496	protein, YerC YecD
MAK48_03645	COG0069	glutamate synthase activity
MAK48_03650	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MAK48_03655	COG0210	DNA helicase
MAK48_03660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MAK48_03665	COG4851	CamS sex pheromone cAM373 precursor
MAK48_03670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MAK48_03675	COG1285	pathogenesis
MAK48_03680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MAK48_03685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAK48_03690	COG0154	amidase activity
MAK48_03695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MAK48_03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MAK48_03710	COG1597	lipid kinase activity
MAK48_03715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MAK48_03720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MAK48_03725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MAK48_03730	COG1002	Type II restriction enzyme, methylase subunits
MAK48_03735	COG1061	Type III restriction enzyme res subunit
MAK48_03740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MAK48_03760	COG5444	nuclease activity
MAK48_03780	COG0457	Tetratricopeptide repeat
MAK48_03790	COG0217	transcriptional regulatory protein
MAK48_03800	COG1309	transcriptional regulator
MAK48_03805	COG3631	Ketosteroid isomerase-related protein
MAK48_03825	COG3546	catalase activity
MAK48_03830	COG0454	-acetyltransferase
MAK48_03840	COG5578	integral membrane protein
MAK48_03845	COG2972	Histidine kinase
MAK48_03850	COG2207	Transcriptional regulator
MAK48_03850	COG4753	response regulator
MAK48_03855	COG1653	transport
MAK48_03860	COG1175	transmembrane transport
MAK48_03865	COG0395	ABC-type sugar transport system, permease component
MAK48_03870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MAK48_03875	COG2207	Transcriptional regulator
MAK48_03880	COG2755	lipolytic protein G-D-S-L family
MAK48_03890	COG5578	integral membrane protein
MAK48_03895	COG3401	FG-GAP repeat protein
MAK48_03900	COG3401	FG-GAP repeat protein
MAK48_03905	COG2755	lipolytic protein G-D-S-L family
MAK48_03910	COG1874	Beta-galactosidase
MAK48_03920	COG1653	transport
MAK48_03925	COG4209	transmembrane transport
MAK48_03930	COG0395	ABC-type sugar transport system, permease component
MAK48_03935	COG1486	melibiose metabolic process
MAK48_03940	COG2323	membrane
MAK48_03945	COG2329	Antibiotic biosynthesis monooxygenase
MAK48_03950	COG0346	lactoylglutathione lyase activity
MAK48_03965	COG5583	Uncharacterized small protein (DUF2292)
MAK48_03970	COG0670	Belongs to the BI1 family
MAK48_03975	COG0697	spore germination
MAK48_03980	COG1846	Transcriptional regulator
MAK48_03985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAK48_03995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MAK48_03995	COG2124	cytochrome p450
MAK48_04000	COG1368	sulfuric ester hydrolase activity
MAK48_04005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MAK48_04010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MAK48_04015	COG1442	glycosyl transferase family 8
MAK48_04020	COG1216	Glycosyl transferase, family 2
MAK48_04025	COG1442	glycosyl transferase family 8
MAK48_04035	COG1011	Hydrolase
MAK48_04040	COG0531	amino acid
MAK48_04045	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_04050	COG0840	transmembrane signaling receptor activity
MAK48_04055	COG0488	(ABC) transporter
MAK48_04065	COG0789	Transcriptional regulator
MAK48_04070	COG2814	Major facilitator Superfamily
MAK48_04080	COG0488	(ABC) transporter
MAK48_04085	COG0513	Belongs to the DEAD box helicase family
MAK48_04090	COG0456	acetyltransferase
MAK48_04095	COG2130	NADP-dependent
MAK48_04100	COG2211	Major facilitator Superfamily
MAK48_04105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MAK48_04110	COG1120	ATPase activity
MAK48_04115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_04120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_04125	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MAK48_04140	COG3866	Pectate lyase
MAK48_04145	COG0471	metal ion transport
MAK48_04150	COG3290	protein histidine kinase activity
MAK48_04155	COG4565	transcriptional regulatory protein
MAK48_04160	COG3181	Tripartite tricarboxylate transporter family receptor
MAK48_04165	COG2851	Citrate transporter
MAK48_04170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_04175	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MAK48_04180	COG1254	Belongs to the acylphosphatase family
MAK48_04185	COG2258	MOSC domain
MAK48_04205	COG0024	Methionine aminopeptidase
MAK48_04210	COG1263	PTS System
MAK48_04210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_04215	COG1368	sulfuric ester hydrolase activity
MAK48_04230	COG1115	amino acid carrier protein
MAK48_04235	COG0531	amino acid
MAK48_04250	COG0697	spore germination
MAK48_04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_04255	COG1263	PTS System
MAK48_04260	COG0366	Alpha amylase catalytic
MAK48_04265	COG2188	Transcriptional regulator
MAK48_04270	COG0778	Nitroreductase
MAK48_04275	COG0737	Belongs to the 5'-nucleotidase family
MAK48_04280	COG0693	protein deglycase activity
MAK48_04285	COG2814	Major facilitator Superfamily
MAK48_04290	COG4840	Belongs to the UPF0435 family
MAK48_04295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAK48_04300	COG4980	gas vesicle protein
MAK48_04305	COG1295	ribonuclease BN
MAK48_04310	COG0477	Major facilitator Superfamily
MAK48_04315	COG0387	Pfam Sodium calcium exchanger
MAK48_04325	COG0668	transmembrane transport
MAK48_04330	COG0535	radical SAM domain protein
MAK48_04340	COG0726	polysaccharide deacetylase
MAK48_04345	COG2084	Dehydrogenase
MAK48_04350	COG0598	Magnesium transport protein CorA
MAK48_04355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MAK48_04360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MAK48_04370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MAK48_04375	COG4637	Psort location Cytoplasmic, score
MAK48_04385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAK48_04390	COG0022	dehydrogenase e1 component
MAK48_04395	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAK48_04400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MAK48_04405	COG3284	Transcriptional regulator
MAK48_04415	COG1742	UPF0060 membrane protein
MAK48_04440	COG4842	Belongs to the WXG100 family
MAK48_04445	COG1486	melibiose metabolic process
MAK48_04450	COG1737	Transcriptional regulator
MAK48_04455	COG1263	PTS System
MAK48_04455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_04460	COG1132	(ABC) transporter
MAK48_04465	COG1132	(ABC) transporter
MAK48_04470	COG2259	Doxx family
MAK48_04475	COG2514	catechol 2,3-dioxygenase activity
MAK48_04480	COG1917	Cupin 2, conserved barrel domain protein
MAK48_04480	COG4977	sequence-specific DNA binding
MAK48_04485	COG2814	Major facilitator Superfamily
MAK48_04490	COG1082	Xylose isomerase domain protein TIM barrel
MAK48_04495	COG0673	inositol 2-dehydrogenase activity
MAK48_04500	COG4585	Histidine kinase
MAK48_04505	COG2197	response regulator
MAK48_04510	COG1131	(ABC) transporter
MAK48_04515	COG0842	Transport permease protein
MAK48_04515	COG1511	domain protein
MAK48_04520	COG0842	Transport permease protein
MAK48_04525	COG1695	Transcriptional regulator
MAK48_04530	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MAK48_04535	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MAK48_04540	COG1309	transcriptional regulator
MAK48_04545	COG2814	Major facilitator Superfamily
MAK48_04550	COG2318	DinB family
MAK48_04555	COG2814	Major facilitator Superfamily
MAK48_04560	COG1846	Transcriptional regulator
MAK48_04565	COG0392	lysyltransferase activity
MAK48_04565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MAK48_04570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MAK48_04575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_04580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_04585	COG0384	phenazine biosynthesis protein PhzF
MAK48_04590	COG0778	Nitroreductase
MAK48_04605	COG1090	epimerase
MAK48_04610	COG2137	regulation of response to DNA damage stimulus
MAK48_04620	COG2814	Major facilitator Superfamily
MAK48_04635	COG3103	Sh3 type 3 domain protein
MAK48_04640	COG5658	integral membrane protein
MAK48_04645	COG0596	Alpha beta hydrolase
MAK48_04650	COG0463	Glycosyl transferase, family 2
MAK48_04655	COG4485	Bacterial membrane protein, YfhO
MAK48_04660	COG1988	membrane-bound metal-dependent
MAK48_04665	COG1194	a g-specific adenine glycosylase
MAK48_04675	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_04690	COG3557	Belongs to the UPF0374 family
MAK48_04695	COG1132	(ABC) transporter
MAK48_04700	COG4129	membrane
MAK48_04705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MAK48_04710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MAK48_04715	COG0735	belongs to the Fur family
MAK48_04825	COG4326	sporulation control protein
MAK48_04835	COG5577	PFAM Coat F domain
MAK48_04840	COG3340	Belongs to the peptidase S51 family
MAK48_04845	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MAK48_04850	COG0277	FAD linked oxidase domain protein
MAK48_04860	COG0753	catalase activity
MAK48_04865	COG1116	anion transmembrane transporter activity
MAK48_04870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MAK48_04875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MAK48_04880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_04890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MAK48_04900	COG1476	TRANSCRIPTIONal
MAK48_04910	COG3382	B3 4 domain protein
MAK48_04915	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MAK48_04925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MAK48_04930	COG0789	Transcriptional regulator
MAK48_04935	COG1664	Polymer-forming cytoskeletal
MAK48_04940	COG1664	Polymer-forming cytoskeletal
MAK48_04945	COG2766	serine protein kinase
MAK48_04950	COG2718	Belongs to the UPF0229 family
MAK48_04955	COG1846	Transcriptional regulator
MAK48_04960	COG1566	PFAM secretion protein HlyD family protein
MAK48_04965	COG2814	Major facilitator Superfamily
MAK48_04970	COG0655	NAD(P)H dehydrogenase (quinone) activity
MAK48_04990	COG1725	Transcriptional regulator
MAK48_04995	COG1131	(ABC) transporter
MAK48_05000	COG1131	(ABC) transporter
MAK48_05005	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MAK48_05010	COG1278	Cold shock
MAK48_05015	COG1464	Belongs to the NlpA lipoprotein family
MAK48_05020	COG3706	GGDEF domain
MAK48_05025	COG1823	symporter activity
MAK48_05045	COG5577	PFAM Coat F domain
MAK48_05050	COG0737	Belongs to the 5'-nucleotidase family
MAK48_05050	COG1525	nuclease
MAK48_05050	COG4085	toxin activity
MAK48_05055	COG3764	Sortase (surface protein transpeptidase)
MAK48_05060	COG0564	pseudouridine synthase activity
MAK48_05070	COG0517	IMP dehydrogenase activity
MAK48_05075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MAK48_05080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MAK48_05080	COG3153	acetyltransferase
MAK48_05085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MAK48_05090	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MAK48_05095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MAK48_05100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MAK48_05105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MAK48_05110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MAK48_05115	COG2203	Gaf domain
MAK48_05115	COG4585	Histidine kinase
MAK48_05120	COG2197	response regulator
MAK48_05125	COG0431	NADPH-dependent FMN reductase
MAK48_05140	COG0791	NLP P60 protein
MAK48_05140	COG1388	LysM domain
MAK48_05145	COG1959	2 iron, 2 sulfur cluster binding
MAK48_05150	COG0668	transmembrane transport
MAK48_05155	COG2719	SpoVR family
MAK48_05160	COG1785	Belongs to the alkaline phosphatase family
MAK48_05165	COG0791	NLP P60 protein
MAK48_05165	COG1388	LysM domain
MAK48_05170	COG0583	DNA-binding transcription factor activity
MAK48_05175	COG0372	Belongs to the citrate synthase family
MAK48_05180	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_05185	COG0531	amino acid
MAK48_05190	COG0733	neurotransmitter:sodium symporter activity
MAK48_05195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAK48_05200	COG0456	acetyltransferase
MAK48_05215	COG1595	DNA-templated transcription, initiation
MAK48_05220	COG0667	Aldo Keto reductase
MAK48_05225	COG0204	Acyl-transferase
MAK48_05230	COG1253	flavin adenine dinucleotide binding
MAK48_05235	COG0789	Transcriptional regulator
MAK48_05240	COG0436	Aminotransferase
MAK48_05245	COG1253	flavin adenine dinucleotide binding
MAK48_05250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MAK48_05255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MAK48_05260	COG0584	glycerophosphoryl diester phosphodiesterase
MAK48_05270	COG0668	transmembrane transport
MAK48_05275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MAK48_05280	COG0726	polysaccharide deacetylase
MAK48_05285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAK48_05290	COG1757	Na H antiporter
MAK48_05295	COG0589	response to stress
MAK48_05305	COG1132	(ABC) transporter
MAK48_05310	COG1132	(ABC) transporter
MAK48_05315	COG0702	epimerase
MAK48_05335	COG0189	ligase activity
MAK48_05340	COG0189	ligase activity
MAK48_05345	COG4399	Belongs to the UPF0754 family
MAK48_05350	COG3679	Belongs to the UPF0342 family
MAK48_05355	COG4335	DNA alkylation repair
MAK48_05360	COG0561	phosphatase activity
MAK48_05365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MAK48_05370	COG0475	glutathione-regulated potassium exporter activity
MAK48_05375	COG0490	domain, Protein
MAK48_05385	COG1024	Enoyl-CoA hydratase
MAK48_05395	COG4152	abc transporter atp-binding protein
MAK48_05400	COG1668	transmembrane transport
MAK48_05405	COG0420	3'-5' exonuclease activity
MAK48_05410	COG4717	serine-type aminopeptidase activity
MAK48_05415	COG3481	metal-dependent phosphohydrolase, HD sub domain
MAK48_05425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MAK48_05455	COG1846	Transcriptional regulator
MAK48_05460	COG4980	gas vesicle protein
MAK48_05475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MAK48_05480	COG0537	adenosine 5'-monophosphoramidase activity
MAK48_05485	COG1131	(ABC) transporter
MAK48_05490	COG4473	ABC transporter
MAK48_05500	COG1473	amidohydrolase
MAK48_05505	COG3069	C4-dicarboxylate transmembrane transporter activity
MAK48_05515	COG2329	Antibiotic biosynthesis monooxygenase
MAK48_05520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MAK48_05525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MAK48_05530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MAK48_05535	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MAK48_05540	COG1309	transcriptional regulator
MAK48_05545	COG1511	domain protein
MAK48_05550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MAK48_05555	COG4377	Putative membrane peptidase family (DUF2324)
MAK48_05565	COG1363	Peptidase, m42
MAK48_05570	COG4405	Protein conserved in bacteria
MAK48_05575	COG1301	dicarboxylic acid transport
MAK48_05585	COG1234	tRNA 3'-trailer cleavage
MAK48_05590	COG0095	Lipoate-protein ligase
MAK48_05595	COG0702	epimerase
MAK48_05600	COG0318	PFAM AMP-dependent synthetase and ligase
MAK48_05610	COG0501	Belongs to the peptidase M48B family
MAK48_05620	COG0456	acetyltransferase
MAK48_05625	COG0604	alcohol dehydrogenase
MAK48_05630	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MAK48_05635	COG0406	alpha-ribazole phosphatase activity
MAK48_05640	COG0183	Belongs to the thiolase family
MAK48_05645	COG0318	PFAM AMP-dependent synthetase and ligase
MAK48_05650	COG1268	BioY protein
MAK48_05655	COG0840	transmembrane signaling receptor activity
MAK48_05660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAK48_05660	COG0723	plastoquinol--plastocyanin reductase activity
MAK48_05665	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_05675	COG4903	ComK protein
MAK48_05680	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_05690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MAK48_05705	COG0398	Pfam SNARE associated Golgi protein
MAK48_05710	COG0681	Belongs to the peptidase S26 family
MAK48_05715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MAK48_05720	COG1846	Transcriptional regulator
MAK48_05725	COG0738	Major facilitator superfamily
MAK48_05730	COG0673	inositol 2-dehydrogenase activity
MAK48_05735	COG0561	phosphatase activity
MAK48_05740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MAK48_05745	COG1609	Transcriptional regulator
MAK48_05750	COG3180	Ammonia monooxygenase
MAK48_05755	COG0477	Major facilitator Superfamily
MAK48_05755	COG2814	Major facilitator Superfamily
MAK48_05760	COG4533	DNA binding
MAK48_05770	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MAK48_05775	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MAK48_05780	COG1074	ATP-dependent DNA helicase activity
MAK48_05785	COG0420	3'-5' exonuclease activity
MAK48_05790	COG0419	ATPase involved in DNA repair
MAK48_05795	COG1403	HNH endonuclease
MAK48_05835	COG5337	Spore coat protein CotH
MAK48_05840	COG0179	Fumarylacetoacetate (FAA) hydrolase
MAK48_05850	COG1404	Belongs to the peptidase S8 family
MAK48_05860	COG0367	asparagine synthase
MAK48_05865	COG2318	DinB family
MAK48_05870	COG1562	ergosterol biosynthetic process
MAK48_05875	COG0534	Mate efflux family protein
MAK48_05880	COG1917	Cupin 2, conserved barrel domain protein
MAK48_05880	COG2207	Transcriptional regulator
MAK48_05885	COG1609	Transcriptional regulator
MAK48_05890	COG0673	inositol 2-dehydrogenase activity
MAK48_05895	COG2318	DinB family
MAK48_05905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MAK48_05910	COG1357	PFAM Pentapeptide repeats (8 copies)
MAK48_05915	COG2267	carboxylic ester hydrolase activity
MAK48_05920	COG0529	Catalyzes the synthesis of activated sulfate
MAK48_05925	COG2046	Belongs to the sulfate adenylyltransferase family
MAK48_05930	COG0175	sulfate reduction
MAK48_05935	COG2045	Belongs to the ComB family
MAK48_05940	COG1809	phosphosulfolactate synthase activity
MAK48_05945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MAK48_05950	COG4948	Mandelate Racemase Muconate Lactonizing
MAK48_05955	COG2814	Major facilitator Superfamily
MAK48_05960	COG0454	-acetyltransferase
MAK48_05965	COG2153	protein acetylation
MAK48_05970	COG0646	methionine synthase
MAK48_05970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MAK48_05975	COG1666	GTP binding
MAK48_05980	COG2996	Protein conserved in bacteria
MAK48_06000	COG1695	Transcriptional regulator
MAK48_06015	COG3227	Zinc metalloprotease (Elastase)
MAK48_06020	COG1307	EDD domain protein, DegV family
MAK48_06025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MAK48_06045	COG0561	phosphatase activity
MAK48_06050	COG1073	alpha beta
MAK48_06055	COG2151	metal-sulfur cluster biosynthetic enzyme
MAK48_06065	COG0277	FAD linked oxidase domain protein
MAK48_06070	COG2271	Major facilitator Superfamily
MAK48_06075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MAK48_06080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MAK48_06090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MAK48_06095	COG0505	Belongs to the CarA family
MAK48_06100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MAK48_06105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MAK48_06120	COG2267	carboxylic ester hydrolase activity
MAK48_06130	COG1744	ABC transporter substrate-binding protein PnrA-like
MAK48_06145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MAK48_06150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MAK48_06155	COG5504	Zn-dependent protease
MAK48_06160	COG0444	Belongs to the ABC transporter superfamily
MAK48_06165	COG4608	Belongs to the ABC transporter superfamily
MAK48_06175	COG0601	transmembrane transport
MAK48_06180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MAK48_06190	COG0180	Tryptophanyl-tRNA synthetase
MAK48_06195	COG4166	transmembrane transport
MAK48_06200	COG0601	transmembrane transport
MAK48_06205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MAK48_06210	COG0444	Belongs to the ABC transporter superfamily
MAK48_06215	COG4608	Belongs to the ABC transporter superfamily
MAK48_06220	COG2814	Major facilitator Superfamily
MAK48_06225	COG0456	acetyltransferase
MAK48_06230	COG1393	Belongs to the ArsC family
MAK48_06235	COG0861	Integral membrane protein TerC family
MAK48_06245	COG4862	establishment of competence for transformation
MAK48_06255	COG4469	Competence protein
MAK48_06260	COG1164	Oligoendopeptidase f
MAK48_06270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MAK48_06275	COG2346	COG2346, Truncated hemoglobins
MAK48_06280	COG0741	lytic transglycosylase activity
MAK48_06285	COG4116	CYTH
MAK48_06295	COG2357	RelA SpoT domain protein
MAK48_06300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MAK48_06305	COG0564	pseudouridine synthase activity
MAK48_06310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MAK48_06315	COG0475	glutathione-regulated potassium exporter activity
MAK48_06315	COG0569	domain protein
MAK48_06320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MAK48_06325	COG0352	thiamine-phosphate diphosphorylase activity
MAK48_06330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAK48_06335	COG2104	thiamine diphosphate biosynthetic process
MAK48_06340	COG2022	thiamine diphosphate biosynthetic process
MAK48_06345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MAK48_06350	COG0351	phosphomethylpyrimidine kinase
MAK48_06355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MAK48_06410	COG0210	DNA helicase
MAK48_06420	COG2153	protein acetylation
MAK48_06425	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MAK48_06430	COG2382	esterase
MAK48_06435	COG0626	cystathionine gamma-synthase activity
MAK48_06440	COG0626	cystathionine gamma-synthase activity
MAK48_06445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_06450	COG5505	Protein of unknown function (DUF819)
MAK48_06475	COG5444	nuclease activity
MAK48_06520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MAK48_06525	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_06535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_06535	COG3711	transcriptional antiterminator
MAK48_06540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MAK48_06540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MAK48_06540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_06545	COG1482	cell wall glycoprotein biosynthetic process
MAK48_06555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_06565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MAK48_06580	COG0109	protoheme IX farnesyltransferase activity
MAK48_06590	COG0726	polysaccharide deacetylase
MAK48_06605	COG5504	Zn-dependent protease
MAK48_06610	COG2205	protein histidine kinase activity
MAK48_06620	COG3383	formate dehydrogenase (NAD+) activity
MAK48_06625	COG2427	Protein of unknown function (DUF1641)
MAK48_06635	COG1051	belongs to the nudix hydrolase family
MAK48_06645	COG2124	cytochrome p450
MAK48_06650	COG1819	glycosyl
MAK48_06660	COG1587	Uroporphyrinogen-III synthase
MAK48_06665	COG0390	transport system, permease component
MAK48_06670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MAK48_06675	COG0697	spore germination
MAK48_06680	COG4297	protein containing double-stranded beta helix domain
MAK48_06690	COG1252	NADH dehydrogenase
MAK48_06695	COG1904	glucuronate isomerase
MAK48_06700	COG2211	Major facilitator Superfamily
MAK48_06705	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MAK48_06710	COG1063	alcohol dehydrogenase
MAK48_06715	COG1312	Catalyzes the dehydration of D-mannonate
MAK48_06720	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_06725	COG2271	Major facilitator Superfamily
MAK48_06730	COG1609	Transcriptional regulator
MAK48_06735	COG0246	Mannitol dehydrogenase
MAK48_06740	COG2721	sulfolactate sulfo-lyase activity
MAK48_06745	COG0730	response to heat
MAK48_06750	COG2318	DinB family
MAK48_06755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MAK48_06760	COG0457	Tetratricopeptide repeat
MAK48_06770	COG2350	Protein conserved in bacteria
MAK48_06775	COG1388	LysM domain
MAK48_06775	COG5632	N-Acetylmuramoyl-L-alanine amidase
MAK48_06775	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_06785	COG4195	phage-related replication protein
MAK48_06790	COG3546	catalase activity
MAK48_06795	COG2856	Zn peptidase
MAK48_06800	COG1396	sequence-specific DNA binding
MAK48_06810	COG1522	sequence-specific DNA binding
MAK48_06815	COG1484	DNA-dependent DNA replication
MAK48_06835	COG1595	DNA-templated transcription, initiation
MAK48_06840	COG5484	DNA packaging
MAK48_06840	COG3728	DNA packaging
MAK48_06845	COG1783	phage Terminase large subunit
MAK48_06850	COG5518	Phage portal protein
MAK48_06855	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MAK48_06860	COG4653	Phage capsid family
MAK48_06910	COG3953	SLT domain
MAK48_06910	COG5412	phage tail tape measure protein
MAK48_06915	COG1652	LysM domain
MAK48_06920	COG4193	domain, Protein
MAK48_06930	COG3628	GPW Gp25 family protein
MAK48_06935	COG3299	homolog of phage Mu protein gp47
MAK48_06940	COG3778	Protein conserved in bacteria
MAK48_06980	COG5632	N-Acetylmuramoyl-L-alanine amidase
MAK48_06980	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_07000	COG0306	phosphate transporter
MAK48_07005	COG1392	Phosphate transport regulator
MAK48_07010	COG0531	amino acid
MAK48_07015	COG0346	lactoylglutathione lyase activity
MAK48_07025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAK48_07030	COG0463	Glycosyl transferase, family 2
MAK48_07040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAK48_07045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MAK48_07050	COG2362	D-Aminopeptidase
MAK48_07055	COG0601	transmembrane transport
MAK48_07060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MAK48_07065	COG0444	Belongs to the ABC transporter superfamily
MAK48_07070	COG4166	transmembrane transport
MAK48_07075	COG1619	proteins homologs of microcin C7 resistance protein MccF
MAK48_07080	COG4948	Mandelate Racemase Muconate Lactonizing
MAK48_07085	COG0791	NLP P60 protein
MAK48_07090	COG4608	Belongs to the ABC transporter superfamily
MAK48_07095	COG2706	6-phosphogluconolactonase activity
MAK48_07100	COG1834	amidinotransferase
MAK48_07105	COG1607	acyl-coa hydrolase
MAK48_07110	COG1017	nitric oxide dioxygenase activity
MAK48_07110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MAK48_07120	COG2323	membrane
MAK48_07125	COG2318	DinB family
MAK48_07130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_07135	COG2076	Multidrug Resistance protein
MAK48_07140	COG2076	Multidrug Resistance protein
MAK48_07145	COG0788	formyltetrahydrofolate deformylase activity
MAK48_07150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MAK48_07155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MAK48_07160	COG1764	response to oxidative stress
MAK48_07165	COG1846	Transcriptional regulator
MAK48_07170	COG1764	response to oxidative stress
MAK48_07180	COG0590	tRNA wobble adenosine to inosine editing
MAK48_07185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MAK48_07190	COG1404	Belongs to the peptidase S8 family
MAK48_07195	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_07200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MAK48_07205	COG1122	ATPase activity
MAK48_07210	COG4721	ABC-type cobalt transport system, permease component
MAK48_07220	COG0745	RESPONSE REGULATOR receiver
MAK48_07225	COG5002	protein histidine kinase activity
MAK48_07225	COG3850	Histidine kinase
MAK48_07230	COG3212	peptidase
MAK48_07235	COG3212	peptidase
MAK48_07245	COG2239	Acts as a magnesium transporter
MAK48_07250	COG0789	Transcriptional regulator
MAK48_07265	COG1846	Transcriptional regulator
MAK48_07270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MAK48_07275	COG0726	polysaccharide deacetylase
MAK48_07280	COG1408	metallophosphoesterase
MAK48_07290	COG0463	Glycosyl transferase, family 2
MAK48_07295	COG3285	dna ligase
MAK48_07295	COG1793	dna ligase
MAK48_07300	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MAK48_07305	COG3300	MHYT domain
MAK48_07305	COG5001	Diguanylate cyclase
MAK48_07310	COG0586	Pfam SNARE associated Golgi protein
MAK48_07315	COG0861	Integral membrane protein TerC family
MAK48_07320	COG1191	sigma factor activity
MAK48_07340	COG0501	Belongs to the peptidase M48B family
MAK48_07345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MAK48_07360	COG3594	Acyltransferase
MAK48_07365	COG5002	protein histidine kinase activity
MAK48_07370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MAK48_07380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MAK48_07385	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MAK48_07390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MAK48_07395	COG0436	Aminotransferase
MAK48_07400	COG1850	ribulose-bisphosphate carboxylase activity
MAK48_07405	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MAK48_07410	COG0235	Class ii aldolase
MAK48_07415	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MAK48_07420	COG3339	Conserved Protein
MAK48_07435	COG3852	Histidine kinase
MAK48_07440	COG1846	Transcriptional regulator
MAK48_07445	COG1360	Flagellar Motor Protein
MAK48_07450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MAK48_07455	COG0542	response to heat
MAK48_07460	COG3949	Membrane
MAK48_07465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MAK48_07470	COG0720	synthase
MAK48_07475	COG0602	queuosine metabolic process
MAK48_07480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MAK48_07485	COG1733	regulation of RNA biosynthetic process
MAK48_07490	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_07495	COG1388	LysM domain
MAK48_07495	COG4641	Protein conserved in bacteria
MAK48_07500	COG1388	LysM domain
MAK48_07505	COG3858	chitin binding
MAK48_07515	COG4873	Protein conserved in bacteria
MAK48_07525	COG3773	Cell wall hydrolase
MAK48_07530	COG2244	polysaccharide biosynthetic process
MAK48_07535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_07540	COG2217	Heavy metal translocating P-type atpase
MAK48_07550	COG0006	proline dipeptidase activity
MAK48_07555	COG1609	Transcriptional regulator
MAK48_07560	COG3711	transcriptional antiterminator
MAK48_07565	COG2190	(PTS) system
MAK48_07565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_07565	COG1263	PTS System
MAK48_07570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_07575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MAK48_07585	COG1533	DNA photolyase activity
MAK48_07590	COG0456	acetyltransferase
MAK48_07595	COG0840	transmembrane signaling receptor activity
MAK48_07600	COG2084	Dehydrogenase
MAK48_07605	COG2340	Cysteine-rich secretory protein family
MAK48_07610	COG0768	penicillin binding
MAK48_07615	COG4191	Histidine kinase
MAK48_07620	COG0436	Aminotransferase
MAK48_07630	COG0835	chemotaxis
MAK48_07630	COG0784	Response regulator, receiver
MAK48_07640	COG2814	Major facilitator Superfamily
MAK48_07645	COG1376	ErfK ybiS ycfS ynhG family protein
MAK48_07650	COG1408	metallophosphoesterase
MAK48_07655	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_07660	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_07665	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_07675	COG2200	EAL domain
MAK48_07680	COG4703	Protein of unknown function (DUF1797)
MAK48_07685	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MAK48_07695	COG0517	IMP dehydrogenase activity
MAK48_07700	COG0583	DNA-binding transcription factor activity
MAK48_07705	COG0716	FMN binding
MAK48_07715	COG0716	FMN binding
MAK48_07720	COG2171	N-acyltransferase activity
MAK48_07725	COG1473	amidohydrolase
MAK48_07735	COG0668	transmembrane transport
MAK48_07740	COG0450	alkyl hydroperoxide reductase
MAK48_07745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_07760	COG0746	molybdenum cofactor guanylyltransferase activity
MAK48_07765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MAK48_07770	COG0303	'Molybdopterin
MAK48_07775	COG1763	Mo-molybdopterin cofactor biosynthetic process
MAK48_07780	COG0314	molybdopterin synthase activity
MAK48_07785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MAK48_07790	COG1132	(ABC) transporter
MAK48_07795	COG1132	(ABC) transporter
MAK48_07805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAK48_07810	COG1136	(ABC) transporter
MAK48_07815	COG0577	efflux transmembrane transporter activity
MAK48_07820	COG1349	DNA-binding transcription factor activity
MAK48_07825	COG1105	Belongs to the carbohydrate kinase PfkB family
MAK48_07830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MAK48_07830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MAK48_07830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_07835	COG0681	Belongs to the peptidase S26 family
MAK48_07845	COG0488	(ABC) transporter
MAK48_07850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MAK48_07855	COG2309	aminopeptidase activity
MAK48_07865	COG1077	Cell shape determining protein MreB Mrl
MAK48_07870	COG2002	toxin-antitoxin pair type II binding
MAK48_07875	COG3852	Histidine kinase
MAK48_07880	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MAK48_07880	COG2105	PFAM AIG2 family protein
MAK48_07885	COG0569	domain protein
MAK48_07890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MAK48_07895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MAK48_07900	COG5503	Protein of unknown function (DUF1447)
MAK48_07905	COG0561	phosphatase activity
MAK48_07910	COG0242	peptide deformylase activity
MAK48_07920	COG0497	DNA recombination
MAK48_07925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAK48_07930	COG0022	dehydrogenase e1 component
MAK48_07935	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAK48_07940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MAK48_07945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_07955	COG1982	Orn Lys Arg decarboxylase major
MAK48_07960	COG4476	Belongs to the UPF0223 family
MAK48_07965	COG4493	Belongs to the UPF0637 family
MAK48_07975	COG0483	inositol monophosphate 1-phosphatase activity
MAK48_07985	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MAK48_08025	COG1217	gtp-binding protein TYPA
MAK48_08035	COG4896	Protein conserved in bacteria
MAK48_08045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MAK48_08050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MAK48_08055	COG2066	Belongs to the glutaminase family
MAK48_08060	COG4838	Belongs to the UPF0358 family
MAK48_08065	COG0772	Belongs to the SEDS family
MAK48_08070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MAK48_08075	COG1612	heme a metabolic process
MAK48_08080	COG0109	protoheme IX farnesyltransferase activity
MAK48_08085	COG2010	Cytochrome c
MAK48_08085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MAK48_08090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MAK48_08095	COG1845	cytochrome c oxidase, subunit III
MAK48_08100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MAK48_08105	COG3336	cytochrome c oxidase
MAK48_08115	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MAK48_08120	COG2340	Cysteine-rich secretory protein family
MAK48_08135	COG3679	Belongs to the UPF0342 family
MAK48_08140	COG4471	UPF0298 protein
MAK48_08145	COG0742	ribosomal rna small subunit methyltransferase
MAK48_08150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MAK48_08155	COG3314	Sporulation integral membrane protein YlbJ
MAK48_08160	COG1752	Esterase of the alpha-beta hydrolase superfamily
MAK48_08165	COG3480	Lon protease (S16) C-terminal proteolytic domain
MAK48_08170	COG1323	Belongs to the UPF0348 family
MAK48_08180	COG1399	metal-binding, possibly nucleic acid-binding protein
MAK48_08195	COG0454	-acetyltransferase
MAK48_08200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MAK48_08205	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MAK48_08210	COG2001	Belongs to the MraZ family
MAK48_08215	COG0275	rRNA processing
MAK48_08220	COG4839	cell division protein FtsL
MAK48_08225	COG0768	penicillin binding
MAK48_08230	COG0768	penicillin binding
MAK48_08235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MAK48_08240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MAK48_08245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MAK48_08250	COG0772	Belongs to the SEDS family
MAK48_08255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MAK48_08260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MAK48_08265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MAK48_08270	COG3879	Bacterial protein of unknown function (DUF881)
MAK48_08275	COG3879	Bacterial protein of unknown function (DUF881)
MAK48_08280	COG3856	small basic protein
MAK48_08285	COG0849	cell division
MAK48_08290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MAK48_08295	COG1404	Belongs to the peptidase S8 family
MAK48_08295	COG4412	M6 family metalloprotease domain protein
MAK48_08305	COG1191	sigma factor activity
MAK48_08310	COG1191	sigma factor activity
MAK48_08315	COG1119	ATPase activity
MAK48_08320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MAK48_08325	COG1873	PFAM PRC-barrel domain
MAK48_08330	COG1496	oxidoreductase activity
MAK48_08335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MAK48_08340	COG1799	cell septum assembly
MAK48_08345	COG0762	integral membrane protein
MAK48_08350	COG2302	S4 RNA-binding domain
MAK48_08355	COG3599	regulation of cell shape
MAK48_08360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MAK48_08365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MAK48_08370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MAK48_08375	COG0564	pseudouridine synthase activity
MAK48_08380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MAK48_08385	COG2233	PERMEase
MAK48_08390	COG0540	Belongs to the ATCase OTCase family
MAK48_08395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MAK48_08400	COG0505	Belongs to the CarA family
MAK48_08405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MAK48_08410	COG0543	2 iron, 2 sulfur cluster binding
MAK48_08415	COG0167	dihydroorotate dehydrogenase activity
MAK48_08420	COG0284	orotidine-5'-phosphate decarboxylase activity
MAK48_08425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MAK48_08430	COG0175	sulfate reduction
MAK48_08435	COG0306	phosphate transporter
MAK48_08440	COG2046	Belongs to the sulfate adenylyltransferase family
MAK48_08445	COG0529	Catalyzes the synthesis of activated sulfate
MAK48_08450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MAK48_08455	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
MAK48_08460	COG1648	precorrin-2 dehydrogenase activity
MAK48_08465	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MAK48_08470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MAK48_08475	COG1561	YicC-like family, N-terminal region
MAK48_08485	COG0194	GDP metabolic process
MAK48_08490	COG1758	RNA polymerase activity
MAK48_08495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MAK48_08500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MAK48_08505	COG0242	peptide deformylase activity
MAK48_08510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MAK48_08515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MAK48_08515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MAK48_08520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MAK48_08525	COG0631	protein serine/threonine phosphatase activity
MAK48_08530	COG0515	serine threonine protein kinase
MAK48_08530	COG2815	serine threonine protein kinase
MAK48_08535	COG1162	GTPase activity
MAK48_08540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MAK48_08545	COG1564	THIamine pyrophosphokinase
MAK48_08555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MAK48_08560	COG1302	Protein conserved in bacteria
MAK48_08565	COG1461	Dihydroxyacetone kinase
MAK48_08570	COG1760	l-serine dehydratase
MAK48_08575	COG1760	l-serine dehydratase
MAK48_08580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MAK48_08585	COG2050	protein possibly involved in aromatic compounds catabolism
MAK48_08585	COG1349	DNA-binding transcription factor activity
MAK48_08590	COG0416	fatty acid biosynthetic process
MAK48_08595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MAK48_08600	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_08610	COG0571	ribonuclease III activity
MAK48_08615	COG1196	nuclear chromosome segregation
MAK48_08620	COG0552	protein localization to endoplasmic reticulum
MAK48_08630	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MAK48_08635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MAK48_08640	COG0228	four-way junction DNA binding
MAK48_08645	COG1837	Belongs to the UPF0109 family
MAK48_08655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MAK48_08660	COG0336	Belongs to the RNA methyltransferase TrmD family
MAK48_08665	COG0335	large ribosomal subunit rRNA binding
MAK48_08670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MAK48_08675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MAK48_08685	COG2257	FlhB HrpN YscU SpaS Family
MAK48_08690	COG0045	succinate-CoA ligase (ADP-forming) activity
MAK48_08695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MAK48_08700	COG0758	DNA mediated transformation
MAK48_08705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MAK48_08710	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MAK48_08715	COG4974	Belongs to the 'phage' integrase family
MAK48_08720	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MAK48_08725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MAK48_08730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MAK48_08735	COG1815	bacterial-type flagellum-dependent cell motility
MAK48_08740	COG1558	bacterial-type flagellum-dependent cell motility
MAK48_08745	COG1677	Flagellar hook-basal body complex protein FliE
MAK48_08750	COG1766	The M ring may be actively involved in energy transduction
MAK48_08755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MAK48_08760	COG1317	bacterial-type flagellum organization
MAK48_08765	COG1157	protein secretion by the type III secretion system
MAK48_08770	COG2882	bacterial-type flagellum organization
MAK48_08775	COG3334	PFAM MgtE intracellular
MAK48_08780	COG3144	bacterial-type flagellum assembly
MAK48_08785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MAK48_08790	COG4786	Flagellar basal body rod
MAK48_08795	COG1582	Flagellar protein (FlbD)
MAK48_08800	COG1580	Controls the rotational direction of flagella during chemotaxis
MAK48_08805	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MAK48_08810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MAK48_08810	COG1776	CheC inhibitor of MCP methylation
MAK48_08815	COG2201	protein-glutamate methylesterase activity
MAK48_08820	COG3190	flagellar
MAK48_08825	COG1338	Plays a role in the flagellum-specific transport system
MAK48_08830	COG1987	bacterial-type flagellum assembly
MAK48_08835	COG1684	flagellar biosynthetic protein fliR
MAK48_08840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MAK48_08845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MAK48_08850	COG1419	protein localization to endoplasmic reticulum
MAK48_08855	COG0455	bacterial-type flagellum organization
MAK48_08860	COG2201	protein-glutamate methylesterase activity
MAK48_08865	COG0643	Histidine kinase
MAK48_08865	COG2198	Histidine kinase
MAK48_08870	COG0835	chemotaxis
MAK48_08875	COG1776	CheC inhibitor of MCP methylation
MAK48_08880	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MAK48_08885	COG1191	sigma factor activity
MAK48_08895	COG0052	Belongs to the universal ribosomal protein uS2 family
MAK48_08900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MAK48_08905	COG0528	UMP kinase activity
MAK48_08910	COG0233	cytoplasmic translational termination
MAK48_08915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MAK48_08920	COG4589	Belongs to the CDS family
MAK48_08925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MAK48_08930	COG0750	zinc metalloprotease
MAK48_08935	COG0442	prolyl-tRNA aminoacylation
MAK48_08940	COG2176	DNA-directed DNA polymerase activity
MAK48_08945	COG0779	Required for maturation of 30S ribosomal subunits
MAK48_08950	COG0195	Participates in both transcription termination and antitermination
MAK48_08955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MAK48_08960	COG1358	cellular component organization or biogenesis
MAK48_08965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MAK48_08970	COG1550	Protein conserved in bacteria
MAK48_08975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MAK48_08980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MAK48_08985	COG0196	riboflavin kinase activity
MAK48_08990	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MAK48_08995	COG1185	polyribonucleotide nucleotidyltransferase activity
MAK48_09000	COG0726	polysaccharide deacetylase
MAK48_09005	COG0612	Peptidase, M16
MAK48_09010	COG1873	PFAM PRC-barrel domain
MAK48_09015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MAK48_09020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MAK48_09025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MAK48_09030	COG0527	aspartate kinase activity
MAK48_09035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MAK48_09040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MAK48_09045	COG0740	serine-type endopeptidase activity
MAK48_09055	COG1674	ftsk spoiiie
MAK48_09055	COG4980	gas vesicle protein
MAK48_09060	COG2188	Transcriptional regulator
MAK48_09065	COG2814	Major facilitator Superfamily
MAK48_09070	COG0612	Peptidase, M16
MAK48_09075	COG0612	Peptidase, M16
MAK48_09080	COG0300	oxidoreductase activity
MAK48_09095	COG1426	Protein conserved in bacteria
MAK48_09100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MAK48_09105	COG1546	Belongs to the CinA family
MAK48_09105	COG1058	Belongs to the CinA family
MAK48_09110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MAK48_09115	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MAK48_09120	COG1418	mRNA catabolic process
MAK48_09125	COG1692	metallophosphoesterase
MAK48_09130	COG2359	stage V sporulation protein S
MAK48_09135	COG1063	alcohol dehydrogenase
MAK48_09140	COG0156	8-amino-7-oxononanoate synthase activity
MAK48_09145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MAK48_09150	COG4550	Control of competence regulator ComK, YlbF/YmcA
MAK48_09160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MAK48_09165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MAK48_09180	COG3226	Transcriptional regulator
MAK48_09185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_09195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MAK48_09200	COG3321	synthase
MAK48_09205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MAK48_09205	COG2070	2-Nitropropane dioxygenase
MAK48_09210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAK48_09215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MAK48_09220	COG3425	synthase
MAK48_09225	COG1024	Enoyl-CoA hydratase
MAK48_09230	COG1024	Enoyl-CoA hydratase
MAK48_09235	COG0318	PFAM AMP-dependent synthetase and ligase
MAK48_09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_09235	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_09235	COG3321	synthase
MAK48_09235	COG0300	oxidoreductase activity
MAK48_09240	COG3321	synthase
MAK48_09240	COG4221	oxidoreductase activity
MAK48_09240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAK48_09240	COG0300	oxidoreductase activity
MAK48_09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAK48_09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_09245	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_09245	COG3321	synthase
MAK48_09245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MAK48_09250	COG3321	synthase
MAK48_09250	COG4221	oxidoreductase activity
MAK48_09250	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_09255	COG3321	synthase
MAK48_09255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MAK48_09255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAK48_09255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MAK48_09260	COG2124	cytochrome p450
MAK48_09270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_09275	COG1404	Belongs to the peptidase S8 family
MAK48_09285	COG4195	phage-related replication protein
MAK48_09290	COG1764	response to oxidative stress
MAK48_09295	COG2076	Multidrug Resistance protein
MAK48_09300	COG2076	Multidrug Resistance protein
MAK48_09315	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MAK48_09320	COG1923	regulation of RNA biosynthetic process
MAK48_09335	COG1780	Probably involved in ribonucleotide reductase function
MAK48_09340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MAK48_09345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MAK48_09350	COG4112	unkown
MAK48_09355	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAK48_09360	COG0464	growth
MAK48_09365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MAK48_09370	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MAK48_09375	COG0789	Transcriptional regulator
MAK48_09380	COG0174	glutamine synthetase
MAK48_09395	COG1396	sequence-specific DNA binding
MAK48_09565	COG5280	Phage tail tape measure protein TP901
MAK48_09565	COG3953	SLT domain
MAK48_09575	COG1705	Flagellar rod assembly protein muramidase FlgJ
MAK48_09580	COG5434	Belongs to the glycosyl hydrolase 28 family
MAK48_09610	COG5632	N-Acetylmuramoyl-L-alanine amidase
MAK48_09610	COG1388	LysM domain
MAK48_09610	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_09620	COG5444	nuclease activity
MAK48_09625	COG0457	Tetratricopeptide repeat
MAK48_09650	COG4282	regulation of fungal-type cell wall biogenesis
MAK48_09660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_09690	COG0135	phosphoribosylanthranilate isomerase activity
MAK48_09695	COG2211	Major facilitator Superfamily
MAK48_09700	COG3507	Belongs to the glycosyl hydrolase 43 family
MAK48_09705	COG1940	carbohydrate kinase activity
MAK48_09710	COG2115	Belongs to the xylose isomerase family
MAK48_09715	COG1070	Carbohydrate kinase
MAK48_09725	COG1525	nuclease
MAK48_09730	COG2814	Major facilitator Superfamily
MAK48_09735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MAK48_09745	COG0756	dUTP diphosphatase activity
MAK48_09785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MAK48_09800	COG3832	glyoxalase III activity
MAK48_09810	COG0697	spore germination
MAK48_09815	COG0531	amino acid
MAK48_09845	COG4195	phage-related replication protein
MAK48_09855	COG0346	lactoylglutathione lyase activity
MAK48_09865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MAK48_09870	COG1388	LysM domain
MAK48_09875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MAK48_09880	COG4224	UPF0291 protein
MAK48_09885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MAK48_09895	COG3763	UPF0154 protein
MAK48_09905	COG0785	Cytochrome C biogenesis protein
MAK48_09910	COG2201	protein-glutamate methylesterase activity
MAK48_09915	COG4846	Membrane protein involved in cytochrome C biogenesis
MAK48_09925	COG0071	Belongs to the small heat shock protein (HSP20) family
MAK48_09940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MAK48_09945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_09965	COG0824	Thioesterase
MAK48_09975	COG4841	protein insertion into membrane
MAK48_09980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MAK48_09985	COG1832	CoA-binding protein
MAK48_09990	COG0187	DNA topoisomerase II activity
MAK48_09995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MAK48_10005	COG1115	amino acid carrier protein
MAK48_10010	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MAK48_10020	COG5520	Belongs to the glycosyl hydrolase 30 family
MAK48_10025	COG3507	Belongs to the glycosyl hydrolase 43 family
MAK48_10030	COG2246	polysaccharide biosynthetic process
MAK48_10035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MAK48_10040	COG0586	Pfam SNARE associated Golgi protein
MAK48_10045	COG2404	hydrolase activity, acting on ester bonds
MAK48_10050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAK48_10055	COG1024	Enoyl-CoA hydratase
MAK48_10060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MAK48_10065	COG0511	ligase activity, forming carbon-carbon bonds
MAK48_10070	COG0439	Biotin carboxylase
MAK48_10075	COG0318	PFAM AMP-dependent synthetase and ligase
MAK48_10080	COG1960	acyl-CoA dehydrogenase activity
MAK48_10095	COG1649	PFAM Uncharacterised BCR, COG1649
MAK48_10105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_10105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MAK48_10110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_10115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_10120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_10125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_10130	COG2027	D-alanyl-D-alanine carboxypeptidase
MAK48_10135	COG2017	converts alpha-aldose to the beta-anomer
MAK48_10140	COG0534	Mate efflux family protein
MAK48_10155	COG0582	viral genome integration into host DNA
MAK48_10160	COG0166	Belongs to the GPI family
MAK48_10165	COG0405	Gamma-glutamyltransferase
MAK48_10170	COG0583	DNA-binding transcription factor activity
MAK48_10175	COG0604	alcohol dehydrogenase
MAK48_10180	COG0493	'glutamate synthase
MAK48_10185	COG0067	glutamate synthase
MAK48_10185	COG0070	glutamate synthase
MAK48_10185	COG0069	glutamate synthase activity
MAK48_10190	COG0583	DNA-binding transcription factor activity
MAK48_10195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MAK48_10200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MAK48_10210	COG0300	oxidoreductase activity
MAK48_10215	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MAK48_10225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MAK48_10230	COG2814	Major facilitator Superfamily
MAK48_10235	COG1070	Carbohydrate kinase
MAK48_10240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MAK48_10245	COG0243	molybdopterin cofactor binding
MAK48_10275	COG5278	phosphoserine phosphatase activity
MAK48_10275	COG0840	transmembrane signaling receptor activity
MAK48_10280	COG2368	4-hydroxyphenylacetate
MAK48_10285	COG4305	rare lipoprotein A
MAK48_10290	COG3619	membrane
MAK48_10295	COG3866	Pectate lyase
MAK48_10300	COG2135	peptidase activity
MAK48_10310	COG2140	Oxalate decarboxylase
MAK48_10325	COG0456	acetyltransferase
MAK48_10345	COG2720	vancomycin resistance protein
MAK48_10355	COG3655	Transcriptional regulator
MAK48_10360	COG3739	integral membrane protein
MAK48_10365	COG0583	DNA-binding transcription factor activity
MAK48_10370	COG0697	spore germination
MAK48_10380	COG0693	protein deglycase activity
MAK48_10385	COG2367	Beta-lactamase
MAK48_10400	COG3848	Pyruvate phosphate dikinase
MAK48_10400	COG0574	Belongs to the PEP-utilizing enzyme family
MAK48_10405	COG0726	polysaccharide deacetylase
MAK48_10410	COG2314	TM2 domain
MAK48_10415	COG1396	sequence-specific DNA binding
MAK48_10435	COG2135	peptidase activity
MAK48_10475	COG0457	Tetratricopeptide repeat
MAK48_10500	COG5290	Psort location Cytoplasmic, score
MAK48_10525	COG5444	nuclease activity
MAK48_10530	COG4282	regulation of fungal-type cell wall biogenesis
MAK48_10535	COG1231	oxidoreductase activity
MAK48_10540	COG5434	Belongs to the glycosyl hydrolase 28 family
MAK48_10545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAK48_10550	COG0662	Cupin 2, conserved barrel domain protein
MAK48_10550	COG2207	Transcriptional regulator
MAK48_10555	COG0456	acetyltransferase
MAK48_10560	COG1309	transcriptional regulator
MAK48_10565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_10570	COG3708	Transcriptional regulator
MAK48_10575	COG2378	regulation of single-species biofilm formation
MAK48_10585	COG0640	Transcriptional regulator
MAK48_10590	COG0741	lytic transglycosylase activity
MAK48_10595	COG2322	membrane
MAK48_10610	COG1619	proteins homologs of microcin C7 resistance protein MccF
MAK48_10615	COG3239	Fatty acid desaturase
MAK48_10620	COG4585	Histidine kinase
MAK48_10625	COG2197	response regulator
MAK48_10630	COG1388	LysM domain
MAK48_10630	COG3584	3D domain protein
MAK48_10635	COG0514	ATP-dependent DNA helicase (RecQ)
MAK48_10645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MAK48_10650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MAK48_10665	COG0071	Belongs to the small heat shock protein (HSP20) family
MAK48_10690	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_10695	COG1657	PFAM Prenyltransferase squalene oxidase
MAK48_10700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MAK48_10705	COG0733	neurotransmitter:sodium symporter activity
MAK48_10710	COG0385	Bile acid
MAK48_10715	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAK48_10720	COG0567	Dehydrogenase, E1 component
MAK48_10725	COG4548	von Willebrand factor, type A
MAK48_10730	COG0714	Associated with various cellular activities
MAK48_10735	COG2032	superoxide dismutase activity
MAK48_10740	COG0791	NLP P60 protein
MAK48_10740	COG1388	LysM domain
MAK48_10745	COG1819	glycosyl
MAK48_10750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MAK48_10755	COG0534	Mate efflux family protein
MAK48_10760	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_10765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MAK48_10770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MAK48_10780	COG2962	Rard protein
MAK48_10795	COG2610	gluconate transmembrane transporter activity
MAK48_10800	COG1942	4-Oxalocrotonate Tautomerase
MAK48_10805	COG1733	regulation of RNA biosynthetic process
MAK48_10810	COG0778	Nitroreductase
MAK48_10815	COG0400	carboxylic ester hydrolase activity
MAK48_10820	COG0346	lactoylglutathione lyase activity
MAK48_10830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MAK48_10835	COG0793	Belongs to the peptidase S41A family
MAK48_10835	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_10840	COG2226	methyltransferase
MAK48_10850	COG1876	peptidase activity
MAK48_10855	COG0813	purine-nucleoside phosphorylase activity
MAK48_10870	COG0671	phosphoesterase, PA-phosphatase related
MAK48_10890	COG4479	Belongs to the UPF0346 family
MAK48_10900	COG1509	lysine 2,3-aminomutase activity
MAK48_10905	COG0456	acetyltransferase
MAK48_10910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MAK48_10915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MAK48_10920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MAK48_10925	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MAK48_10940	COG0456	acetyltransferase
MAK48_10945	COG0463	Glycosyl transferase, family 2
MAK48_10960	COG4641	Protein conserved in bacteria
MAK48_10965	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
MAK48_10970	COG1086	Polysaccharide biosynthesis protein
MAK48_10975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MAK48_10980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MAK48_10985	COG1846	Transcriptional regulator
MAK48_10990	COG0534	Mate efflux family protein
MAK48_11000	COG4698	Protein conserved in bacteria
MAK48_11005	COG2755	lipolytic protein G-D-S-L family
MAK48_11010	COG1999	signal sequence binding
MAK48_11020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MAK48_11025	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MAK48_11030	COG1272	protein, Hemolysin III
MAK48_11035	COG0204	Acyl-transferase
MAK48_11040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MAK48_11045	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MAK48_11050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MAK48_11060	COG2521	methyltransferase
MAK48_11060	COG2136	Putative SAM-dependent methyltransferase
MAK48_11070	COG0129	dihydroxy-acid dehydratase activity
MAK48_11075	COG1413	lyase activity
MAK48_11080	COG1418	mRNA catabolic process
MAK48_11085	COG0386	Belongs to the glutathione peroxidase family
MAK48_11090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MAK48_11095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MAK48_11105	COG1278	Cold shock
MAK48_11125	COG0328	RNA-DNA hybrid ribonuclease activity
MAK48_11130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MAK48_11135	COG0328	RNA-DNA hybrid ribonuclease activity
MAK48_11145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MAK48_11160	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MAK48_11170	COG1755	Isoprenylcysteine carboxyl methyltransferase
MAK48_11175	COG3424	synthase
MAK48_11180	COG2233	PERMEase
MAK48_11185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAK48_11190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MAK48_11200	COG0800	Aldolase
MAK48_11205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAK48_11210	COG1609	Transcriptional regulator
MAK48_11215	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
MAK48_11220	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_11225	COG1199	ATP-dependent helicase activity
MAK48_11240	COG0116	Belongs to the methyltransferase superfamily
MAK48_11255	COG4474	Belongs to the UPF0398 family
MAK48_11270	COG3359	exonuclease
MAK48_11275	COG1205	dead DEAH box helicase
MAK48_11275	COG1111	helicase
MAK48_11280	COG2190	(PTS) system
MAK48_11285	COG0071	Belongs to the small heat shock protein (HSP20) family
MAK48_11320	COG3331	DNA recombination
MAK48_11325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MAK48_11325	COG4499	WXG100 protein secretion system (Wss), protein YukC
MAK48_11335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MAK48_11340	COG3935	DnaD domain protein
MAK48_11345	COG0017	Asparaginyl-tRNA synthetase
MAK48_11350	COG0436	Aminotransferase
MAK48_11355	COG5353	protein conserved in bacteria
MAK48_11365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MAK48_11365	COG1199	ATP-dependent helicase activity
MAK48_11370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MAK48_11375	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MAK48_11380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MAK48_11385	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MAK48_11385	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MAK48_11390	COG0617	tRNA 3'-terminal CCA addition
MAK48_11395	COG0438	transferase activity, transferring glycosyl groups
MAK48_11400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MAK48_11405	COG1803	Methylglyoxal synthase
MAK48_11410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MAK48_11415	COG1694	Mazg nucleotide pyrophosphohydrolase
MAK48_11420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MAK48_11430	COG4347	Protein of unknown function (DUF1405)
MAK48_11435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MAK48_11435	COG2010	Cytochrome c
MAK48_11440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MAK48_11445	COG0723	plastoquinol--plastocyanin reductase activity
MAK48_11455	COG5582	Belongs to the UPF0302 family
MAK48_11460	COG0457	Tetratricopeptide repeat
MAK48_11465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MAK48_11470	COG0287	Prephenate dehydrogenase
MAK48_11475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MAK48_11480	COG0159	tryptophan synthase activity
MAK48_11485	COG0133	tryptophan synthase activity
MAK48_11490	COG0135	phosphoribosylanthranilate isomerase activity
MAK48_11500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MAK48_11505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MAK48_11510	COG4401	Chorismate mutase type I
MAK48_11515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MAK48_11520	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MAK48_11525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MAK48_11530	COG0105	UTP biosynthetic process
MAK48_11535	COG0142	geranyltranstransferase activity
MAK48_11540	COG2226	methyltransferase
MAK48_11545	COG0142	geranyltranstransferase activity
MAK48_11555	COG0302	gtp cyclohydrolase
MAK48_11560	COG0776	regulation of translation
MAK48_11565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MAK48_11580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MAK48_11585	COG1160	GTP binding
MAK48_11610	COG1304	FMN binding
MAK48_11615	COG0539	negative regulation of cytoplasmic translation
MAK48_11620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MAK48_11630	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MAK48_11635	COG2959	enzyme of heme biosynthesis
MAK48_11640	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_11640	COG3773	Cell wall hydrolase
MAK48_11645	COG2339	peptidase activity
MAK48_11650	COG0492	ferredoxin-NADP+ reductase activity
MAK48_11655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MAK48_11660	COG4862	establishment of competence for transformation
MAK48_11665	COG1408	metallophosphoesterase
MAK48_11675	COG1388	LysM domain
MAK48_11680	COG1266	CAAX protease self-immunity
MAK48_11685	COG0514	ATP-dependent DNA helicase (RecQ)
MAK48_11690	COG4955	Helix-turn-helix domain
MAK48_11695	COG1141	Ferredoxin
MAK48_11700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MAK48_11705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MAK48_11710	COG0710	3-dehydroquinate dehydratase activity
MAK48_11720	COG1595	DNA-templated transcription, initiation
MAK48_11725	COG5002	protein histidine kinase activity
MAK48_11730	COG0745	RESPONSE REGULATOR receiver
MAK48_11735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MAK48_11740	COG1333	cytochrome c biogenesis protein
MAK48_11745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_11750	COG1187	pseudouridine synthase activity
MAK48_11755	COG0700	Nucleoside recognition
MAK48_11760	COG2715	membrane protein required for spore maturation
MAK48_11765	COG1686	Belongs to the peptidase S11 family
MAK48_11775	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MAK48_11780	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MAK48_11785	COG1547	Domain of unknown function (DUF309)
MAK48_11790	COG0456	acetyltransferase
MAK48_11795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MAK48_11800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAK48_11800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MAK48_11805	COG0307	riboflavin synthase, alpha
MAK48_11810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MAK48_11810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MAK48_11820	COG0681	Belongs to the peptidase S26 family
MAK48_11830	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MAK48_11845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MAK48_11850	COG4086	secreted protein
MAK48_11855	COG0019	diaminopimelate decarboxylase activity
MAK48_11860	COG0697	spore germination
MAK48_11875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MAK48_11895	COG1191	sigma factor activity
MAK48_11900	COG2172	sigma factor antagonist activity
MAK48_11905	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_11910	COG1686	Belongs to the peptidase S11 family
MAK48_11915	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MAK48_11920	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MAK48_11925	COG4974	Belongs to the 'phage' integrase family
MAK48_11935	COG0735	belongs to the Fur family
MAK48_11940	COG1300	Membrane
MAK48_11950	COG0281	malic enzyme
MAK48_11955	COG1757	Na H antiporter
MAK48_11960	COG1027	Aspartate ammonia-lyase
MAK48_11965	COG0252	asparaginase activity
MAK48_11970	COG1396	sequence-specific DNA binding
MAK48_11975	COG1379	DNA repair
MAK48_11980	COG0494	nUDIX hydrolase
MAK48_11990	COG0667	Aldo Keto reductase
MAK48_12000	COG1073	alpha beta
MAK48_12010	COG4918	Iron-sulphur cluster biosynthesis
MAK48_12015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MAK48_12015	COG0456	acetyltransferase
MAK48_12020	COG2329	Antibiotic biosynthesis monooxygenase
MAK48_12025	COG0456	acetyltransferase
MAK48_12035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MAK48_12045	COG2211	Major facilitator Superfamily
MAK48_12055	COG0346	lactoylglutathione lyase activity
MAK48_12060	COG1072	(Pantothenic acid kinase))
MAK48_12065	COG3048	D-serine ammonia-lyase activity
MAK48_12070	COG0300	oxidoreductase activity
MAK48_12075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_12080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MAK48_12085	COG4187	Peptidase family M20/M25/M40
MAK48_12090	COG1902	pentaerythritol trinitrate reductase activity
MAK48_12095	COG0596	Alpha beta hydrolase
MAK48_12105	COG1234	tRNA 3'-trailer cleavage
MAK48_12110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MAK48_12115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MAK48_12120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MAK48_12130	COG0706	membrane insertase activity
MAK48_12135	COG3361	conserved protein (COG2071)
MAK48_12140	COG2195	Cleaves the N-terminal amino acid of tripeptides
MAK48_12145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MAK48_12150	COG0346	lactoylglutathione lyase activity
MAK48_12160	COG1376	ErfK ybiS ycfS ynhG family protein
MAK48_12165	COG4129	membrane
MAK48_12170	COG1126	abc transporter atp-binding protein
MAK48_12175	COG0765	amino acid transport
MAK48_12180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAK48_12190	COG1597	lipid kinase activity
MAK48_12195	COG2814	Major facilitator Superfamily
MAK48_12200	COG0789	Transcriptional regulator
MAK48_12200	COG4978	Transcriptional regulator
MAK48_12205	COG0508	dehydrogenase complex catalyzes the overall conversion of
MAK48_12210	COG0022	dehydrogenase e1 component
MAK48_12215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MAK48_12220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MAK48_12225	COG3426	butyrate kinase activity
MAK48_12230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MAK48_12235	COG0280	phosphate acetyltransferase
MAK48_12240	COG3290	protein histidine kinase activity
MAK48_12240	COG3829	transcription factor binding
MAK48_12250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MAK48_12255	COG2079	MmgE PrpD family protein
MAK48_12260	COG0372	Belongs to the citrate synthase family
MAK48_12265	COG1960	acyl-CoA dehydrogenase activity
MAK48_12270	COG1250	3-hydroxyacyl-CoA dehydrogenase
MAK48_12275	COG0183	Belongs to the thiolase family
MAK48_12280	COG0584	glycerophosphoryl diester phosphodiesterase
MAK48_12285	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAK48_12300	COG1902	pentaerythritol trinitrate reductase activity
MAK48_12305	COG0745	RESPONSE REGULATOR receiver
MAK48_12310	COG0750	zinc metalloprotease
MAK48_12315	COG0497	DNA recombination
MAK48_12320	COG1438	arginine binding
MAK48_12325	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MAK48_12330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MAK48_12335	COG0142	geranyltranstransferase activity
MAK48_12340	COG1722	exodeoxyribonuclease VII activity
MAK48_12345	COG1570	exodeoxyribonuclease VII activity
MAK48_12350	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MAK48_12355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MAK48_12360	COG1302	Protein conserved in bacteria
MAK48_12365	COG0439	Biotin carboxylase
MAK48_12370	COG0511	ligase activity, forming carbon-carbon bonds
MAK48_12410	COG3854	ATPases associated with a variety of cellular activities
MAK48_12420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MAK48_12425	COG0006	proline dipeptidase activity
MAK48_12430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MAK48_12440	COG3872	metal-dependent enzyme
MAK48_12450	COG1752	Esterase of the alpha-beta hydrolase superfamily
MAK48_12455	COG1321	iron dependent repressor
MAK48_12460	COG0095	Lipoate-protein ligase
MAK48_12465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MAK48_12470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MAK48_12475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MAK48_12480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MAK48_12485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MAK48_12500	COG1396	sequence-specific DNA binding
MAK48_12510	COG0681	Belongs to the peptidase S26 family
MAK48_12535	COG4940	Competence protein ComGF
MAK48_12545	COG4970	Tfp pilus assembly protein FimT
MAK48_12550	COG4537	Required for transformation and DNA binding
MAK48_12555	COG1459	type II secretion system
MAK48_12560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MAK48_12565	COG0598	Magnesium transport protein CorA
MAK48_12570	COG1253	flavin adenine dinucleotide binding
MAK48_12575	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_12585	COG1393	Belongs to the ArsC family
MAK48_12595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_12605	COG0011	TIGRFAM Protein of
MAK48_12615	COG2866	Carboxypeptidase
MAK48_12620	COG1368	sulfuric ester hydrolase activity
MAK48_12625	COG1940	carbohydrate kinase activity
MAK48_12630	COG4483	Protein conserved in bacteria
MAK48_12635	COG0705	Rhomboid family
MAK48_12635	COG0457	Tetratricopeptide repeat
MAK48_12645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MAK48_12670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MAK48_12675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MAK48_12680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MAK48_12685	COG0581	inorganic phosphate transmembrane transporter activity
MAK48_12690	COG0573	inorganic phosphate transmembrane transporter activity
MAK48_12695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MAK48_12700	COG0768	penicillin binding
MAK48_12705	COG0477	Major facilitator Superfamily
MAK48_12710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MAK48_12715	COG2839	Protein conserved in bacteria
MAK48_12720	COG5521	maltodextrose utilization protein MalA
MAK48_12730	COG1388	LysM domain
MAK48_12735	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MAK48_12740	COG4709	membrane
MAK48_12745	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MAK48_12750	COG0735	belongs to the Fur family
MAK48_12755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MAK48_12765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MAK48_12770	COG0513	Belongs to the DEAD box helicase family
MAK48_12780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MAK48_12785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MAK48_12790	COG2384	SAM-dependent methyltransferase
MAK48_12795	COG2010	Cytochrome c
MAK48_12800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MAK48_12805	COG0358	DNA primase activity
MAK48_12810	COG1671	Belongs to the UPF0178 family
MAK48_12815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MAK48_12820	COG0517	IMP dehydrogenase activity
MAK48_12825	COG0751	glycine-tRNA ligase activity
MAK48_12830	COG0752	glycyl-tRNA synthetase alpha subunit
MAK48_12835	COG1381	Involved in DNA repair and RecF pathway recombination
MAK48_12845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MAK48_12850	COG0295	cytidine deaminase activity
MAK48_12855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MAK48_12860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MAK48_12865	COG1480	7TM receptor with intracellular HD hydrolase
MAK48_12870	COG1702	phosphate starvation-inducible protein PhoH
MAK48_12875	COG0561	phosphatase activity
MAK48_12890	COG4864	UPF0365 protein
MAK48_12895	COG1030	water channel activity
MAK48_12900	COG1610	YqeY-like protein
MAK48_12910	COG1283	sodium-dependent phosphate transmembrane transporter activity
MAK48_12915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MAK48_12920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MAK48_12925	COG2264	protein methyltransferase activity
MAK48_12930	COG0484	heat shock protein binding
MAK48_12935	COG0443	Heat shock 70 kDa protein
MAK48_12940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MAK48_12945	COG1420	regulation of RNA biosynthetic process
MAK48_12950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MAK48_12955	COG0481	GTPase activity
MAK48_12965	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAK48_12970	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MAK48_12975	COG0268	Binds directly to 16S ribosomal RNA
MAK48_12980	COG1466	dna polymerase III delta subunit
MAK48_12995	COG2333	competence protein COMEC
MAK48_12995	COG0658	competence protein
MAK48_13000	COG2131	deaminase
MAK48_13005	COG1555	photosystem II stabilization
MAK48_13005	COG1596	polysaccharide export
MAK48_13010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MAK48_13015	COG2226	methyltransferase
MAK48_13020	COG0799	negative regulation of ribosome biogenesis
MAK48_13025	COG1713	HD superfamily hydrolase involved in NAD metabolism
MAK48_13030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MAK48_13035	COG1534	Rna-binding protein
MAK48_13040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MAK48_13045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MAK48_13050	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MAK48_13060	COG2755	lipolytic protein G-D-S-L family
MAK48_13065	COG5632	N-Acetylmuramoyl-L-alanine amidase
MAK48_13065	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_13070	COG0398	Pfam SNARE associated Golgi protein
MAK48_13075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MAK48_13085	COG3209	COG3209 Rhs family protein
MAK48_13095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MAK48_13105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAK48_13110	COG0798	PFAM Bile acid sodium symporter
MAK48_13115	COG0346	lactoylglutathione lyase activity
MAK48_13120	COG0640	Transcriptional regulator
MAK48_13125	COG3403	YqcI/YcgG family
MAK48_13130	COG0457	Tetratricopeptide repeat
MAK48_13145	COG5444	nuclease activity
MAK48_13170	COG5632	N-Acetylmuramoyl-L-alanine amidase
MAK48_13170	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_13175	COG4824	toxin secretion phage lysis holin
MAK48_13205	COG3778	Protein conserved in bacteria
MAK48_13210	COG3299	homolog of phage Mu protein gp47
MAK48_13215	COG3628	GPW Gp25 family protein
MAK48_13225	COG4193	domain, Protein
MAK48_13230	COG1652	LysM domain
MAK48_13235	COG5280	Phage tail tape measure protein TP901
MAK48_13235	COG3953	SLT domain
MAK48_13300	COG4653	Phage capsid family
MAK48_13305	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MAK48_13315	COG2369	cell adhesion
MAK48_13320	COG5518	Phage portal protein
MAK48_13325	COG1783	phage Terminase large subunit
MAK48_13330	COG5484	DNA packaging
MAK48_13340	COG3677	Transposase
MAK48_13355	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
MAK48_13365	COG1484	DNA-dependent DNA replication
MAK48_13370	COG3935	DnaD domain protein
MAK48_13375	COG3723	Recombinational DNA repair protein, rece pathway
MAK48_13380	COG5377	YqaJ viral recombinase family
MAK48_13410	COG1476	TRANSCRIPTIONal
MAK48_13415	COG3620	sequence-specific DNA binding
MAK48_13425	COG0563	adenylate kinase activity
MAK48_13430	COG2856	Zn peptidase
MAK48_13455	COG3223	Belongs to the PsiE family
MAK48_13460	COG0642	Histidine kinase
MAK48_13460	COG5002	protein histidine kinase activity
MAK48_13465	COG0745	RESPONSE REGULATOR receiver
MAK48_13470	COG2311	Membrane
MAK48_13480	COG0454	-acetyltransferase
MAK48_13485	COG2249	NAD(P)H dehydrogenase (quinone) activity
MAK48_13495	COG0730	response to heat
MAK48_13500	COG0425	Belongs to the sulfur carrier protein TusA family
MAK48_13515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MAK48_13515	COG0425	Belongs to the sulfur carrier protein TusA family
MAK48_13525	COG2210	Belongs to the sulfur carrier protein TusA family
MAK48_13530	COG1937	Protein conserved in bacteria
MAK48_13540	COG0662	Cupin 2, conserved barrel domain protein
MAK48_13555	COG0789	Transcriptional regulator
MAK48_13555	COG4978	Transcriptional regulator
MAK48_13560	COG2814	Major facilitator Superfamily
MAK48_13565	COG0456	acetyltransferase
MAK48_13570	COG1253	flavin adenine dinucleotide binding
MAK48_13580	COG0697	spore germination
MAK48_13585	COG0583	DNA-binding transcription factor activity
MAK48_13590	COG2072	flavoprotein involved in K transport
MAK48_13595	COG1230	cation diffusion facilitator family transporter
MAK48_13600	COG1942	4-Oxalocrotonate Tautomerase
MAK48_13605	COG0583	DNA-binding transcription factor activity
MAK48_13615	COG1114	Component of the transport system for branched-chain amino acids
MAK48_13620	COG1687	branched-chain amino acid
MAK48_13625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MAK48_13630	COG1522	sequence-specific DNA binding
MAK48_13635	COG2732	(Barnase) inhibitor
MAK48_13640	COG2124	cytochrome p450
MAK48_13650	COG1335	isochorismatase
MAK48_13665	COG2318	DinB family
MAK48_13675	COG2070	2-Nitropropane dioxygenase
MAK48_13680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MAK48_13700	COG3443	Belongs to the bacterial solute-binding protein 9 family
MAK48_13705	COG1595	DNA-templated transcription, initiation
MAK48_13710	COG0667	Aldo Keto reductase
MAK48_13715	COG2851	Citrate transporter
MAK48_13720	COG0583	DNA-binding transcription factor activity
MAK48_13725	COG2828	Protein conserved in bacteria
MAK48_13730	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_13735	COG5566	PFAM Mor transcription activator
MAK48_13740	COG0596	Alpha beta hydrolase
MAK48_13745	COG4991	sh3 domain protein
MAK48_13750	COG4991	sh3 domain protein
MAK48_13760	COG0346	lactoylglutathione lyase activity
MAK48_13770	COG5577	PFAM Coat F domain
MAK48_13775	COG1063	alcohol dehydrogenase
MAK48_13785	COG5577	PFAM Coat F domain
MAK48_13790	COG0789	Transcriptional regulator
MAK48_13800	COG1064	alcohol dehydrogenase
MAK48_13805	COG0693	protein deglycase activity
MAK48_13810	COG1621	beta-fructofuranosidase activity
MAK48_13820	COG3716	PTS system mannose fructose sorbose family IID component
MAK48_13825	COG3715	PTS system
MAK48_13830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_13835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_13840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MAK48_13840	COG3933	PFAM sigma-54 factor interaction domain-containing protein
MAK48_13850	COG1113	amino acid transport
MAK48_13855	COG1280	lysine exporter protein (LysE YggA)
MAK48_13860	COG1378	Sugar-specific transcriptional regulator TrmB
MAK48_13865	COG1595	DNA-templated transcription, initiation
MAK48_13875	COG2755	lipolytic protein G-D-S-L family
MAK48_13875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MAK48_13885	COG2124	cytochrome p450
MAK48_13885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MAK48_13890	COG1309	transcriptional regulator
MAK48_13895	COG2226	methyltransferase
MAK48_13910	COG2116	formate transmembrane transporter activity
MAK48_13915	COG5609	conserved protein (DUF2294)
MAK48_13920	COG3383	formate dehydrogenase (NAD+) activity
MAK48_13925	COG2427	Protein of unknown function (DUF1641)
MAK48_13935	COG0626	cystathionine gamma-synthase activity
MAK48_13940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MAK48_13945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MAK48_13950	COG2226	methyltransferase
MAK48_13965	COG0768	penicillin binding
MAK48_13970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MAK48_13975	COG0572	uridine kinase
MAK48_13980	COG0826	peptidase U32
MAK48_13985	COG0826	peptidase U32
MAK48_13990	COG4122	O-methyltransferase activity
MAK48_13995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MAK48_14000	COG3906	Belongs to the UPF0473 family
MAK48_14005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MAK48_14010	COG4472	Bacterial protein of unknown function (DUF965)
MAK48_14015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MAK48_14020	COG0628	permease
MAK48_14025	COG1126	abc transporter atp-binding protein
MAK48_14030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAK48_14035	COG0765	amino acid transport
MAK48_14040	COG0765	amino acid transport
MAK48_14055	COG3881	PFAM PRC-barrel domain
MAK48_14060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MAK48_14065	COG0457	Tetratricopeptide repeat
MAK48_14070	COG0482	sulfurtransferase activity
MAK48_14075	COG1104	cysteine desulfurase activity
MAK48_14080	COG1959	2 iron, 2 sulfur cluster binding
MAK48_14085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MAK48_14090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MAK48_14100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MAK48_14105	COG0124	histidyl-tRNA synthetase
MAK48_14115	COG4991	sh3 domain protein
MAK48_14115	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAK48_14115	COG3103	Sh3 type 3 domain protein
MAK48_14120	COG1490	D-aminoacyl-tRNA deacylase activity
MAK48_14125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MAK48_14130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MAK48_14135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MAK48_14135	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MAK48_14140	COG5416	Lipopolysaccharide assembly protein A domain
MAK48_14145	COG0490	domain, Protein
MAK48_14150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAK48_14150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MAK48_14160	COG2244	polysaccharide biosynthetic process
MAK48_14165	COG2323	membrane
MAK48_14175	COG1862	Preprotein translocase
MAK48_14180	COG0343	queuine tRNA-ribosyltransferase activity
MAK48_14185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MAK48_14195	COG2255	four-way junction helicase activity
MAK48_14200	COG0632	four-way junction helicase activity
MAK48_14210	COG2814	Major facilitator Superfamily
MAK48_14215	COG0673	inositol 2-dehydrogenase activity
MAK48_14220	COG2112	serine threonine protein kinase
MAK48_14240	COG1115	amino acid carrier protein
MAK48_14245	COG0217	transcriptional regulatory protein
MAK48_14255	COG1388	LysM domain
MAK48_14260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MAK48_14265	COG0157	Belongs to the NadC ModD family
MAK48_14270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MAK48_14275	COG1104	cysteine desulfurase activity
MAK48_14280	COG1827	regulation of RNA biosynthetic process
MAK48_14285	COG0077	Prephenate dehydratase
MAK48_14290	COG4492	Belongs to the UPF0735 family
MAK48_14295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MAK48_14300	COG3290	protein histidine kinase activity
MAK48_14310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MAK48_14315	COG2868	ribosomal protein
MAK48_14320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MAK48_14325	COG1994	Peptidase M50
MAK48_14330	COG0739	heme binding
MAK48_14335	COG2894	cell division
MAK48_14340	COG0850	regulation of cytokinetic process
MAK48_14345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MAK48_14355	COG1077	Cell shape determining protein MreB Mrl
MAK48_14360	COG2003	Belongs to the UPF0758 family
MAK48_14365	COG0424	maF-like protein
MAK48_14375	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MAK48_14380	COG0285	dihydrofolate synthase activity
MAK48_14385	COG0525	valine-tRNA ligase activity
MAK48_14395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MAK48_14400	COG1388	LysM domain
MAK48_14405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MAK48_14410	COG0113	porphobilinogen synthase activity
MAK48_14415	COG1587	Uroporphyrinogen-III synthase
MAK48_14420	COG0181	hydroxymethylbilane synthase activity
MAK48_14425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MAK48_14430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MAK48_14440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MAK48_14445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MAK48_14450	COG1067	ATP-dependent peptidase activity
MAK48_14450	COG0470	DNA polymerase III
MAK48_14455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MAK48_14460	COG0544	peptidyl-prolyl cis-trans isomerase activity
MAK48_14465	COG1477	protein flavinylation
MAK48_14465	COG0457	Tetratricopeptide repeat
MAK48_14470	COG0066	3-isopropylmalate dehydratase activity
MAK48_14475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MAK48_14480	COG0473	3-isopropylmalate dehydrogenase activity
MAK48_14485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MAK48_14490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MAK48_14495	COG0440	acetolactate synthase activity
MAK48_14500	COG0028	Belongs to the TPP enzyme family
MAK48_14510	COG0454	-acetyltransferase
MAK48_14515	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MAK48_14525	COG0622	Phosphoesterase
MAK48_14530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MAK48_14535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MAK48_14540	COG5401	PFAM Sporulation and spore germination
MAK48_14545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MAK48_14550	COG1846	Transcriptional regulator
MAK48_14555	COG2197	response regulator
MAK48_14560	COG0824	Thioesterase
MAK48_14565	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MAK48_14570	COG1053	succinate dehydrogenase
MAK48_14575	COG2009	succinate dehydrogenase
MAK48_14580	COG1719	4-vinyl reductase, 4VR
MAK48_14585	COG0527	aspartate kinase activity
MAK48_14590	COG0322	excinuclease ABC activity
MAK48_14595	COG3118	belongs to the thioredoxin family
MAK48_14600	COG3534	alpha-L-arabinofuranosidase
MAK48_14605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MAK48_14610	COG2086	electron transfer activity
MAK48_14615	COG1024	Enoyl-CoA hydratase
MAK48_14620	COG1309	transcriptional regulator
MAK48_14625	COG0318	PFAM AMP-dependent synthetase and ligase
MAK48_14630	COG3766	membrane
MAK48_14635	COG1193	negative regulation of DNA recombination
MAK48_14640	COG1796	DNA polymerase
MAK48_14640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MAK48_14645	COG1286	toxin biosynthetic process
MAK48_14650	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MAK48_14655	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MAK48_14660	COG0072	phenylalanine-tRNA ligase activity
MAK48_14660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAK48_14665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MAK48_14675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MAK48_14685	COG3835	regulator
MAK48_14690	COG0277	FAD linked oxidase domain protein
MAK48_14695	COG0247	lactate metabolic process
MAK48_14700	COG0346	lactoylglutathione lyase activity
MAK48_14710	COG1966	Carbon starvation protein
MAK48_14715	COG3534	alpha-L-arabinofuranosidase
MAK48_14720	COG0395	ABC-type sugar transport system, permease component
MAK48_14725	COG1175	transmembrane transport
MAK48_14730	COG1653	transport
MAK48_14735	COG0371	Dehydrogenase
MAK48_14740	COG0647	UMP catabolic process
MAK48_14745	COG0235	Class ii aldolase
MAK48_14750	COG1069	ribulokinase activity
MAK48_14755	COG2160	L-arabinose isomerase activity
MAK48_14760	COG3507	Belongs to the glycosyl hydrolase 43 family
MAK48_14765	COG1363	Peptidase, m42
MAK48_14775	COG3326	Membrane
MAK48_14780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MAK48_14785	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MAK48_14790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MAK48_14800	COG1346	cytolysis
MAK48_14805	COG1380	Effector of murein hydrolase LrgA
MAK48_14810	COG3279	Response regulator of the LytR AlgR family
MAK48_14815	COG3275	phosphorelay sensor kinase activity
MAK48_14820	COG1011	Hydrolase
MAK48_14825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MAK48_14835	COG0398	Pfam SNARE associated Golgi protein
MAK48_14840	COG1484	DNA-dependent DNA replication
MAK48_14845	COG3611	Membrane attachment protein
MAK48_14850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MAK48_14855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MAK48_14860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MAK48_14865	COG1733	regulation of RNA biosynthetic process
MAK48_14870	COG2814	Major facilitator Superfamily
MAK48_14875	COG0656	L-ascorbic acid biosynthetic process
MAK48_14880	COG0237	dephospho-CoA kinase activity
MAK48_14885	COG1971	Probably functions as a manganese efflux pump
MAK48_14890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MAK48_14895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MAK48_14895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MAK48_14900	COG5002	protein histidine kinase activity
MAK48_14905	COG0745	RESPONSE REGULATOR receiver
MAK48_14910	COG0039	L-malate dehydrogenase activity
MAK48_14915	COG0538	isocitrate dehydrogenase activity
MAK48_14920	COG0372	Belongs to the citrate synthase family
MAK48_14925	COG2707	UPF0756 membrane protein
MAK48_14930	COG0628	permease
MAK48_14935	COG3030	protein affecting phage T7 exclusion by the F plasmid
MAK48_14940	COG0469	pyruvate kinase activity
MAK48_14945	COG0205	6-phosphofructokinase activity
MAK48_14950	COG0825	malonyl-CoA metabolic process
MAK48_14955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MAK48_14960	COG0281	malic enzyme
MAK48_14965	COG0587	DNA-directed DNA polymerase activity
MAK48_14985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MAK48_14995	COG4109	DRTGG domain
MAK48_15000	COG0730	response to heat
MAK48_15005	COG1473	amidohydrolase
MAK48_15010	COG0196	riboflavin kinase activity
MAK48_15015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_15020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MAK48_15025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_15030	COG1126	abc transporter atp-binding protein
MAK48_15035	COG0765	amino acid transport
MAK48_15040	COG0765	amino acid transport
MAK48_15045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAK48_15050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAK48_15055	COG0454	-acetyltransferase
MAK48_15060	COG0583	DNA-binding transcription factor activity
MAK48_15065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MAK48_15070	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_15075	COG0165	Argininosuccinate lyase
MAK48_15080	COG0137	argininosuccinate synthase activity
MAK48_15085	COG0521	Mo-molybdopterin cofactor biosynthetic process
MAK48_15090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MAK48_15100	COG0827	DNA restriction-modification system
MAK48_15105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MAK48_15110	COG3874	Sporulation protein YtfJ
MAK48_15120	COG1714	RDD family
MAK48_15125	COG0616	signal peptide processing
MAK48_15130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MAK48_15135	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MAK48_15140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MAK48_15150	COG0301	tRNA thio-modification
MAK48_15155	COG1104	cysteine desulfurase activity
MAK48_15160	COG1114	Component of the transport system for branched-chain amino acids
MAK48_15165	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MAK48_15170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MAK48_15175	COG1309	transcriptional regulator
MAK48_15180	COG1956	GAF domain-containing protein
MAK48_15185	COG2199	diguanylate cyclase activity
MAK48_15185	COG2203	Gaf domain
MAK48_15190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MAK48_15195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MAK48_15200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MAK48_15205	COG0454	-acetyltransferase
MAK48_15210	COG0517	IMP dehydrogenase activity
MAK48_15215	COG0123	including yeast histone deacetylase and acetoin utilization protein
MAK48_15220	COG1360	Flagellar Motor Protein
MAK48_15225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MAK48_15230	COG1609	Transcriptional regulator
MAK48_15235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MAK48_15235	COG1605	Chorismate mutase
MAK48_15240	COG3118	belongs to the thioredoxin family
MAK48_15245	COG4980	gas vesicle protein
MAK48_15250	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MAK48_15255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MAK48_15260	COG1674	ftsk spoiiie
MAK48_15265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MAK48_15270	COG4848	Belongs to the UPF0354 family
MAK48_15275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_15290	COG1363	Peptidase, m42
MAK48_15295	COG5584	Small secreted protein
MAK48_15300	COG0281	malic enzyme
MAK48_15305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_15310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MAK48_15320	COG0510	thiamine kinase activity
MAK48_15325	COG1523	belongs to the glycosyl hydrolase 13 family
MAK48_15330	COG1597	lipid kinase activity
MAK48_15340	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MAK48_15345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MAK48_15350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MAK48_15355	COG2252	PERMEase
MAK48_15360	COG4473	ABC transporter
MAK48_15365	COG1131	(ABC) transporter
MAK48_15370	COG1349	DNA-binding transcription factor activity
MAK48_15375	COG1187	pseudouridine synthase activity
MAK48_15380	COG2244	polysaccharide biosynthetic process
MAK48_15385	COG2081	HI0933 family
MAK48_15390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MAK48_15400	COG5578	integral membrane protein
MAK48_15405	COG0673	inositol 2-dehydrogenase activity
MAK48_15410	COG1653	transport
MAK48_15415	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MAK48_15420	COG4209	transmembrane transport
MAK48_15425	COG2207	Transcriptional regulator
MAK48_15430	COG1653	transport
MAK48_15435	COG0395	ABC-type sugar transport system, permease component
MAK48_15440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MAK48_15445	COG2124	cytochrome p450
MAK48_15450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MAK48_15460	COG0156	8-amino-7-oxononanoate synthase activity
MAK48_15465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MAK48_15475	COG1073	alpha beta
MAK48_15480	COG1609	Transcriptional regulator
MAK48_15485	COG1653	transport
MAK48_15490	COG1175	transmembrane transport
MAK48_15495	COG0395	ABC-type sugar transport system, permease component
MAK48_15500	COG1486	melibiose metabolic process
MAK48_15505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MAK48_15510	COG0495	leucyl-tRNA aminoacylation
MAK48_15520	COG1366	Belongs to the anti-sigma-factor antagonist family
MAK48_15520	COG2202	Pas domain
MAK48_15525	COG2814	Major facilitator Superfamily
MAK48_15530	COG2433	Pfam Transposase IS66
MAK48_15535	COG0577	efflux transmembrane transporter activity
MAK48_15540	COG1136	(ABC) transporter
MAK48_15545	COG2205	protein histidine kinase activity
MAK48_15550	COG0745	RESPONSE REGULATOR receiver
MAK48_15555	COG0577	efflux transmembrane transporter activity
MAK48_15560	COG1136	(ABC) transporter
MAK48_15575	COG1131	(ABC) transporter
MAK48_15580	COG1725	Transcriptional regulator
MAK48_15595	COG1242	4 iron, 4 sulfur cluster binding
MAK48_15600	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MAK48_15610	COG2267	carboxylic ester hydrolase activity
MAK48_15615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MAK48_15620	COG1113	amino acid transport
MAK48_15625	COG0367	asparagine synthase
MAK48_15630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MAK48_15635	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MAK48_15645	COG1506	peptidase
MAK48_15650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MAK48_15655	COG1116	anion transmembrane transporter activity
MAK48_15660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MAK48_15665	COG0494	nUDIX hydrolase
MAK48_15670	COG4824	toxin secretion phage lysis holin
MAK48_15675	COG0783	Belongs to the Dps family
MAK48_15690	COG1854	S-ribosylhomocysteine lyase activity
MAK48_15695	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MAK48_15700	COG0288	reversible hydration of carbon dioxide
MAK48_15705	COG0254	rRNA binding
MAK48_15710	COG1271	oxidase subunit
MAK48_15715	COG1294	oxidase, subunit
MAK48_15725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MAK48_15730	COG1321	iron dependent repressor
MAK48_15730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MAK48_15735	COG1121	(ABC) transporter
MAK48_15740	COG0803	Belongs to the bacterial solute-binding protein 9 family
MAK48_15745	COG4948	Mandelate Racemase Muconate Lactonizing
MAK48_15750	COG0318	PFAM AMP-dependent synthetase and ligase
MAK48_15755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MAK48_15760	COG0596	Alpha beta hydrolase
MAK48_15765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MAK48_15770	COG1169	isochorismate synthase
MAK48_15775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MAK48_15780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MAK48_15785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAK48_15790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MAK48_15795	COG0438	transferase activity, transferring glycosyl groups
MAK48_15805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MAK48_15810	COG0438	transferase activity, transferring glycosyl groups
MAK48_15815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MAK48_15820	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MAK48_15825	COG0058	SHG alpha-glucan phosphorylase activity
MAK48_15830	COG0297	glycogen (starch) synthase activity
MAK48_15835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MAK48_15840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MAK48_15845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MAK48_15970	COG3859	Proton-coupled thiamine transporter YuaJ
MAK48_15975	COG1247	-acetyltransferase
MAK48_15980	COG2268	Band 7 protein
MAK48_15985	COG1585	Membrane protein implicated in regulation of membrane protease activity
MAK48_15990	COG2318	DinB family
MAK48_16000	COG1454	alcohol dehydrogenase
MAK48_16005	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_16010	COG1510	regulation of RNA biosynthetic process
MAK48_16020	COG0569	domain protein
MAK48_16025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MAK48_16030	COG4682	membrane
MAK48_16035	COG1705	Flagellar rod assembly protein muramidase FlgJ
MAK48_16040	COG0477	Major facilitator Superfamily
MAK48_16045	COG5553	Cysteine dioxygenase type I
MAK48_16055	COG1968	undecaprenyl-diphosphatase activity
MAK48_16060	COG0628	permease
MAK48_16065	COG0673	inositol 2-dehydrogenase activity
MAK48_16070	COG4806	L-rhamnose isomerase
MAK48_16075	COG3254	rhamnose metabolic process
MAK48_16080	COG1070	Carbohydrate kinase
MAK48_16085	COG1349	DNA-binding transcription factor activity
MAK48_16090	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_16090	COG3347	Dehydrogenase
MAK48_16095	COG0840	transmembrane signaling receptor activity
MAK48_16100	COG0840	transmembrane signaling receptor activity
MAK48_16105	COG0840	transmembrane signaling receptor activity
MAK48_16110	COG0840	transmembrane signaling receptor activity
MAK48_16125	COG0432	Pfam Uncharacterised protein family UPF0047
MAK48_16135	COG0366	Alpha amylase catalytic
MAK48_16140	COG1253	flavin adenine dinucleotide binding
MAK48_16145	COG2738	Putative neutral zinc metallopeptidase
MAK48_16160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MAK48_16175	COG0166	Belongs to the GPI family
MAK48_16180	COG1979	alcohol dehydrogenase
MAK48_16185	COG1979	alcohol dehydrogenase
MAK48_16190	COG2155	Conserved Protein
MAK48_16195	COG1098	S1 RNA binding domain
MAK48_16200	COG0436	Aminotransferase
MAK48_16205	COG1522	sequence-specific DNA binding
MAK48_16210	COG2267	carboxylic ester hydrolase activity
MAK48_16220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MAK48_16225	COG2205	protein histidine kinase activity
MAK48_16235	COG5018	Exonuclease
MAK48_16245	COG2814	Major facilitator Superfamily
MAK48_16250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MAK48_16255	COG3011	Protein conserved in bacteria
MAK48_16265	COG3290	protein histidine kinase activity
MAK48_16270	COG4565	transcriptional regulatory protein
MAK48_16275	COG1744	ABC transporter substrate-binding protein PnrA-like
MAK48_16280	COG3845	ABC transporter
MAK48_16285	COG4603	Belongs to the binding-protein-dependent transport system permease family
MAK48_16290	COG1079	Belongs to the binding-protein-dependent transport system permease family
MAK48_16295	COG3493	citrate carrier protein
MAK48_16305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MAK48_16305	COG2111	Na H antiporter
MAK48_16310	COG2111	Na H antiporter
MAK48_16315	COG1006	Multisubunit Na H antiporter MnhC subunit
MAK48_16320	COG0651	ATP synthesis coupled electron transport
MAK48_16325	COG1863	multisubunit Na H antiporter MnhE subunit
MAK48_16330	COG2212	antiporter activity
MAK48_16335	COG1320	monovalent cation:proton antiporter activity
MAK48_16340	COG2050	protein possibly involved in aromatic compounds catabolism
MAK48_16345	COG2197	response regulator
MAK48_16350	COG4585	Histidine kinase
MAK48_16360	COG0142	geranyltranstransferase activity
MAK48_16380	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MAK48_16385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MAK48_16390	COG1335	isochorismatase
MAK48_16395	COG5506	Protein of unknown function (DUF1694)
MAK48_16410	COG0628	permease
MAK48_16425	COG1418	mRNA catabolic process
MAK48_16430	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_16440	COG1511	domain protein
MAK48_16445	COG1674	ftsk spoiiie
MAK48_16445	COG0433	COG0433 Predicted ATPase
MAK48_16450	COG4499	WXG100 protein secretion system (Wss), protein YukC
MAK48_16455	COG5417	Belongs to the EsaB family
MAK48_16460	COG4842	Belongs to the WXG100 family
MAK48_16465	COG2508	Transcriptional regulator
MAK48_16465	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MAK48_16470	COG0686	Belongs to the AlaDH PNT family
MAK48_16475	COG5634	Uncharacterized conserved protein (DUF2278)
MAK48_16480	COG3251	PFAM MbtH domain protein
MAK48_16485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_16490	COG1535	isochorismatase
MAK48_16490	COG3433	isochorismatase activity
MAK48_16495	COG1021	2,3-dihydroxybenzoate-AMP ligase
MAK48_16500	COG1169	isochorismate synthase
MAK48_16505	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_16510	COG2819	hydrolase of the alpha beta superfamily
MAK48_16515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MAK48_16520	COG1268	BioY protein
MAK48_16525	COG2056	Na+-H+ antiporter family
MAK48_16530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MAK48_16535	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MAK48_16540	COG3584	3D domain protein
MAK48_16555	COG1252	NADH dehydrogenase
MAK48_16560	COG0492	ferredoxin-NADP+ reductase activity
MAK48_16570	COG0516	GMP reductase activity
MAK48_16575	COG2808	Putative FMN-binding domain
MAK48_16580	COG0456	acetyltransferase
MAK48_16585	COG0316	Belongs to the HesB IscA family
MAK48_16590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MAK48_16595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MAK48_16600	COG4844	belongs to the
MAK48_16605	COG1252	NADH dehydrogenase
MAK48_16610	COG4837	Protein of unknown function (DUF1462)
MAK48_16615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MAK48_16620	COG1506	peptidase
MAK48_16620	COG4946	Tricorn protease homolog
MAK48_16620	COG0823	Involved in the tonB-independent uptake of proteins
MAK48_16625	COG0083	homoserine kinase activity
MAK48_16630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MAK48_16635	COG0460	homoserine dehydrogenase
MAK48_16640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MAK48_16645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MAK48_16650	COG0647	UMP catabolic process
MAK48_16655	COG2445	Protein of unknown function DUF86
MAK48_16660	COG4470	Protein conserved in bacteria
MAK48_16670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MAK48_16675	COG0739	heme binding
MAK48_16685	COG3377	Domain of unknown function (DUF1805)
MAK48_16690	COG0737	Belongs to the 5'-nucleotidase family
MAK48_16695	COG0730	response to heat
MAK48_16700	COG1801	Protein of unknown function DUF72
MAK48_16710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MAK48_16715	COG2508	Transcriptional regulator
MAK48_16720	COG2233	PERMEase
MAK48_16725	COG2233	PERMEase
MAK48_16730	COG3195	allantoin biosynthetic process
MAK48_16730	COG3648	Uricase
MAK48_16735	COG2351	hydroxyisourate hydrolase activity
MAK48_16745	COG2080	2 iron, 2 sulfur cluster binding
MAK48_16750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MAK48_16755	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MAK48_16760	COG2068	MobA-Related Protein
MAK48_16765	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MAK48_16770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MAK48_16775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MAK48_16785	COG2356	endonuclease I
MAK48_16790	COG3842	ATPase activity
MAK48_16795	COG2188	Transcriptional regulator
MAK48_16800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAK48_16805	COG0395	ABC-type sugar transport system, permease component
MAK48_16810	COG1175	transmembrane transport
MAK48_16815	COG1653	transport
MAK48_16820	COG2222	sugar isomerase
MAK48_16825	COG0322	excinuclease ABC activity
MAK48_16830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MAK48_16845	COG0346	lactoylglutathione lyase activity
MAK48_16850	COG0640	Transcriptional regulator
MAK48_16855	COG0719	Fe-S assembly protein
MAK48_16860	COG0822	iron-sulfur transferase activity
MAK48_16865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MAK48_16870	COG0719	Fe-S assembly protein
MAK48_16875	COG0396	ATPase activity
MAK48_16885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MAK48_16890	COG1464	Belongs to the NlpA lipoprotein family
MAK48_16895	COG2011	ABC-type metal ion transport system permease component
MAK48_16900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MAK48_16910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MAK48_16915	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MAK48_16925	COG0509	glycine decarboxylation via glycine cleavage system
MAK48_16930	COG1393	Belongs to the ArsC family
MAK48_16935	COG1960	acyl-CoA dehydrogenase activity
MAK48_16940	COG0183	Belongs to the thiolase family
MAK48_16945	COG1250	3-hydroxyacyl-CoA dehydrogenase
MAK48_16945	COG1024	Enoyl-CoA hydratase
MAK48_16955	COG0506	proline dehydrogenase activity
MAK48_16965	COG5577	PFAM Coat F domain
MAK48_16970	COG1846	Transcriptional regulator
MAK48_16975	COG0477	Major facilitator Superfamily
MAK48_16980	COG1942	4-Oxalocrotonate Tautomerase
MAK48_16990	COG0583	DNA-binding transcription factor activity
MAK48_17000	COG1120	ATPase activity
MAK48_17015	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_17020	COG0783	Belongs to the Dps family
MAK48_17025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAK48_17030	COG0745	RESPONSE REGULATOR receiver
MAK48_17035	COG2205	protein histidine kinase activity
MAK48_17035	COG2770	Histidine kinase
MAK48_17045	COG1309	transcriptional regulator
MAK48_17050	COG0114	fumarate hydratase activity
MAK48_17060	COG0697	spore germination
MAK48_17065	COG0814	amino acid
MAK48_17075	COG2197	response regulator
MAK48_17080	COG4585	Histidine kinase
MAK48_17085	COG4758	membrane
MAK48_17090	COG3595	metallopeptidase activity
MAK48_17095	COG1842	Phage shock protein A
MAK48_17100	COG4758	membrane
MAK48_17105	COG2814	Major facilitator Superfamily
MAK48_17110	COG2096	Adenosyltransferase
MAK48_17115	COG1120	ATPase activity
MAK48_17120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_17125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MAK48_17130	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_17135	COG3386	PFAM SMP-30 Gluconolaconase
MAK48_17140	COG2205	protein histidine kinase activity
MAK48_17145	COG0745	RESPONSE REGULATOR receiver
MAK48_17155	COG1191	sigma factor activity
MAK48_17165	COG2140	Oxalate decarboxylase
MAK48_17175	COG0577	efflux transmembrane transporter activity
MAK48_17180	COG1136	(ABC) transporter
MAK48_17185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MAK48_17190	COG1120	ATPase activity
MAK48_17195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_17200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MAK48_17205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MAK48_17210	COG0531	amino acid
MAK48_17220	COG1988	membrane-bound metal-dependent
MAK48_17225	COG1368	sulfuric ester hydrolase activity
MAK48_17230	COG1910	domain protein
MAK48_17235	COG0725	ABC transporter, periplasmic molybdate-binding protein
MAK48_17240	COG4149	molybdate abc transporter
MAK48_17245	COG0656	L-ascorbic acid biosynthetic process
MAK48_17255	COG0025	NhaP-type Na H and K H
MAK48_17260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MAK48_17265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MAK48_17270	COG3973	AAA domain
MAK48_17275	COG2860	membrane
MAK48_17280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MAK48_17285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MAK48_17290	COG2217	Heavy metal translocating P-type atpase
MAK48_17295	COG2217	Heavy metal translocating P-type atpase
MAK48_17300	COG2608	mercury ion transmembrane transporter activity
MAK48_17305	COG1937	Protein conserved in bacteria
MAK48_17310	COG0673	inositol 2-dehydrogenase activity
MAK48_17315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MAK48_17320	COG1289	transmembrane transporter activity
MAK48_17330	COG2076	Multidrug Resistance protein
MAK48_17335	COG1309	transcriptional regulator
MAK48_17340	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_17350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MAK48_17355	COG0557	exoribonuclease II activity
MAK48_17360	COG1647	Serine aminopeptidase, S33
MAK48_17365	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MAK48_17370	COG0596	Alpha beta hydrolase
MAK48_17375	COG1476	TRANSCRIPTIONal
MAK48_17380	COG1396	sequence-specific DNA binding
MAK48_17385	COG1396	sequence-specific DNA binding
MAK48_17390	COG1733	regulation of RNA biosynthetic process
MAK48_17395	COG0840	transmembrane signaling receptor activity
MAK48_17400	COG1174	glycine betaine transport
MAK48_17405	COG1732	Glycine betaine
MAK48_17410	COG1174	glycine betaine transport
MAK48_17415	COG0517	IMP dehydrogenase activity
MAK48_17415	COG1125	glycine betaine transport
MAK48_17420	COG1510	regulation of RNA biosynthetic process
MAK48_17440	COG5658	integral membrane protein
MAK48_17445	COG0640	Transcriptional regulator
MAK48_17450	COG1174	glycine betaine transport
MAK48_17455	COG1732	Glycine betaine
MAK48_17460	COG1174	glycine betaine transport
MAK48_17465	COG0517	IMP dehydrogenase activity
MAK48_17465	COG1125	glycine betaine transport
MAK48_17470	COG1510	regulation of RNA biosynthetic process
MAK48_17475	COG2095	MarC family integral membrane protein
MAK48_17485	COG3064	Membrane
MAK48_17490	COG4640	response to antibiotic
MAK48_17495	COG0456	acetyltransferase
MAK48_17500	COG0148	phosphopyruvate hydratase activity
MAK48_17505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MAK48_17510	COG0149	triose-phosphate isomerase activity
MAK48_17515	COG0126	phosphoglycerate kinase activity
MAK48_17520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MAK48_17525	COG2390	Transcriptional regulator
MAK48_17530	COG2814	Major facilitator Superfamily
MAK48_17535	COG1609	Transcriptional regulator
MAK48_17540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_17545	COG0583	DNA-binding transcription factor activity
MAK48_17550	COG0697	spore germination
MAK48_17555	COG1113	amino acid transport
MAK48_17560	COG3858	chitin binding
MAK48_17565	COG1556	Lactate utilization protein
MAK48_17570	COG1139	Iron-sulfur cluster binding protein
MAK48_17575	COG0247	lactate metabolic process
MAK48_17580	COG2197	response regulator
MAK48_17585	COG4585	Histidine kinase
MAK48_17590	COG0842	Transport permease protein
MAK48_17595	COG1131	(ABC) transporter
MAK48_17600	COG0596	Alpha beta hydrolase
MAK48_17605	COG2208	phosphoserine phosphatase activity
MAK48_17610	COG3867	Arabinogalactan endo-beta-1,4-galactanase
MAK48_17615	COG1874	Beta-galactosidase
MAK48_17620	COG3833	ABC-type maltose transport systems, permease component
MAK48_17625	COG1175	transmembrane transport
MAK48_17630	COG2182	Extracellular solute-binding protein
MAK48_17635	COG1609	Transcriptional regulator
MAK48_17640	COG2186	Transcriptional regulator
MAK48_17645	COG1620	l-lactate permease
MAK48_17650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MAK48_17660	COG5039	Polysaccharide pyruvyl transferase
MAK48_17665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MAK48_17670	COG0110	maltose O-acetyltransferase activity
MAK48_17675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MAK48_17680	COG2244	polysaccharide biosynthetic process
MAK48_17685	COG1216	Glycosyl transferase, family 2
MAK48_17690	COG5039	Polysaccharide pyruvyl transferase
MAK48_17695	COG1216	Glycosyl transferase, family 2
MAK48_17705	COG0438	transferase activity, transferring glycosyl groups
MAK48_17710	COG1215	transferase activity, transferring glycosyl groups
MAK48_17715	COG0438	transferase activity, transferring glycosyl groups
MAK48_17720	COG1086	Polysaccharide biosynthesis protein
MAK48_17725	COG0489	protein tyrosine kinase activity
MAK48_17730	COG3944	biosynthesis protein
MAK48_17735	COG1396	sequence-specific DNA binding
MAK48_17740	COG2272	Belongs to the type-B carboxylesterase lipase family
MAK48_17750	COG3479	Phenolic acid decarboxylase
MAK48_17760	COG1794	racemase activity, acting on amino acids and derivatives
MAK48_17770	COG1621	beta-fructofuranosidase activity
MAK48_17775	COG1621	beta-fructofuranosidase activity
MAK48_17780	COG0531	amino acid
MAK48_17785	COG1309	transcriptional regulator
MAK48_17790	COG2076	Multidrug Resistance protein
MAK48_17795	COG2076	Multidrug Resistance protein
MAK48_17805	COG0277	FAD linked oxidase domain protein
MAK48_17810	COG3621	Patatin-like phospholipase
MAK48_17820	COG0740	serine-type endopeptidase activity
MAK48_17825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MAK48_17830	COG0366	Alpha amylase catalytic
MAK48_17835	COG1554	hydrolase, family 65, central catalytic
MAK48_17840	COG5521	maltodextrose utilization protein MalA
MAK48_17845	COG3833	ABC-type maltose transport systems, permease component
MAK48_17850	COG1175	transmembrane transport
MAK48_17855	COG2182	Extracellular solute-binding protein
MAK48_17860	COG0366	Alpha amylase catalytic
MAK48_17865	COG1609	Transcriptional regulator
MAK48_17870	COG1611	Belongs to the LOG family
MAK48_17875	COG1694	Mazg nucleotide pyrophosphohydrolase
MAK48_17880	COG0659	secondary active sulfate transmembrane transporter activity
MAK48_17885	COG0288	reversible hydration of carbon dioxide
MAK48_17890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MAK48_17895	COG0577	efflux transmembrane transporter activity
MAK48_17900	COG1136	(ABC) transporter
MAK48_17905	COG5002	protein histidine kinase activity
MAK48_17910	COG0745	RESPONSE REGULATOR receiver
MAK48_17920	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MAK48_17925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_17930	COG1481	regulation of sporulation
MAK48_17935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MAK48_17940	COG1660	Displays ATPase and GTPase activities
MAK48_17945	COG1051	belongs to the nudix hydrolase family
MAK48_17950	COG0492	ferredoxin-NADP+ reductase activity
MAK48_17955	COG3883	PFAM NLP P60 protein
MAK48_17955	COG0791	NLP P60 protein
MAK48_17960	COG0457	Tetratricopeptide repeat
MAK48_17965	COG1132	(ABC) transporter
MAK48_17985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MAK48_17985	COG0140	phosphoribosyl-ATP diphosphatase activity
MAK48_17990	COG0107	imidazoleglycerol-phosphate synthase activity
MAK48_17995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MAK48_18000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MAK48_18005	COG0131	Imidazoleglycerol-phosphate dehydratase
MAK48_18010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MAK48_18015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MAK48_18020	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MAK48_18025	COG4990	cell redox homeostasis
MAK48_18030	COG5297	Belongs to the glycosyl hydrolase family 6
MAK48_18035	COG0110	maltose O-acetyltransferase activity
MAK48_18040	COG0546	phosphoglycolate phosphatase activity
MAK48_18045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MAK48_18050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MAK48_18055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MAK48_18060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MAK48_18065	COG0363	glucosamine-6-phosphate deaminase activity
MAK48_18070	COG2188	Transcriptional regulator
MAK48_18075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MAK48_18080	COG1846	Transcriptional regulator
MAK48_18085	COG2124	cytochrome p450
MAK48_18095	COG1846	Transcriptional regulator
MAK48_18100	COG2814	Major facilitator Superfamily
MAK48_18105	COG1950	PFAM Membrane protein of
MAK48_18110	COG1983	PspC domain protein
MAK48_18115	COG3595	metallopeptidase activity
MAK48_18135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MAK48_18140	COG0556	nucleotide-excision repair
MAK48_18145	COG4897	Protein conserved in bacteria
MAK48_18150	COG0574	Belongs to the PEP-utilizing enzyme family
MAK48_18150	COG3848	Pyruvate phosphate dikinase
MAK48_18155	COG1309	transcriptional regulator
MAK48_18160	COG2814	Major facilitator Superfamily
MAK48_18165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAK48_18175	COG0793	Belongs to the peptidase S41A family
MAK48_18175	COG3409	Peptidoglycan-binding domain 1 protein
MAK48_18180	COG2177	Part of the ABC transporter FtsEX involved in
MAK48_18185	COG2884	Cell division ATP-binding protein ftsE
MAK48_18190	COG2010	Cytochrome c
MAK48_18195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MAK48_18205	COG0653	protein targeting
MAK48_18210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MAK48_18225	COG1516	flagellar protein fliS
MAK48_18230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MAK48_18235	COG1334	flagellar protein FlaG
MAK48_18240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MAK48_18245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MAK48_18250	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MAK48_18260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MAK48_18265	COG1256	bacterial-type flagellum assembly
MAK48_18265	COG4786	Flagellar basal body rod
MAK48_18270	COG3418	PFAM FlgN family protein
MAK48_18275	COG2747	anti-sigma28 factor FlgM
MAK48_18285	COG1040	competence protein
MAK48_18295	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MAK48_18300	COG1307	EDD domain protein, DegV family
MAK48_18305	COG2197	response regulator
MAK48_18310	COG4585	Histidine kinase
MAK48_18315	COG1739	Uncharacterized protein family UPF0029
MAK48_18320	COG1316	TRANSCRIPTIONal
MAK48_18325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MAK48_18330	COG0438	transferase activity, transferring glycosyl groups
MAK48_18335	COG1215	transferase activity, transferring glycosyl groups
MAK48_18340	COG3206	protein involved in exopolysaccharide biosynthesis
MAK48_18345	COG3307	-O-antigen
MAK48_18350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAK48_18355	COG0297	glycogen (starch) synthase activity
MAK48_18355	COG0438	transferase activity, transferring glycosyl groups
MAK48_18360	COG2244	polysaccharide biosynthetic process
MAK48_18370	COG2247	cell wall binding repeat
MAK48_18370	COG0860	N-Acetylmuramoyl-L-alanine amidase
MAK48_18375	COG2247	cell wall binding repeat
MAK48_18375	COG2385	sporulation resulting in formation of a cellular spore
MAK48_18385	COG1316	TRANSCRIPTIONal
MAK48_18390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MAK48_18395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MAK48_18405	COG1215	transferase activity, transferring glycosyl groups
MAK48_18405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MAK48_18410	COG0463	Glycosyl transferase, family 2
MAK48_18430	COG1134	teichoic acid transport
MAK48_18435	COG1682	transport, permease protein
MAK48_18440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MAK48_18445	COG0438	transferase activity, transferring glycosyl groups
MAK48_18450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MAK48_18455	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MAK48_18460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MAK48_18470	COG4193	domain, Protein
MAK48_18475	COG1482	cell wall glycoprotein biosynthetic process
MAK48_18480	COG0697	spore germination
MAK48_18485	COG0814	amino acid
MAK48_18495	COG2814	Major facilitator Superfamily
MAK48_18500	COG1316	TRANSCRIPTIONal
MAK48_18505	COG0561	phosphatase activity
MAK48_18510	COG0791	NLP P60 protein
MAK48_18520	COG2843	Capsule synthesis protein
MAK48_18530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MAK48_18535	COG1609	Transcriptional regulator
MAK48_18540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAK48_18545	COG1869	D-ribose catabolic process
MAK48_18550	COG1129	ABC transporter
MAK48_18555	COG1172	Belongs to the binding-protein-dependent transport system permease family
MAK48_18560	COG1879	ABC-type sugar transport system periplasmic component
MAK48_18565	COG3103	Sh3 type 3 domain protein
MAK48_18575	COG2249	NAD(P)H dehydrogenase (quinone) activity
MAK48_18580	COG3527	Alpha-acetolactate decarboxylase
MAK48_18585	COG0028	Belongs to the TPP enzyme family
MAK48_18590	COG0583	DNA-binding transcription factor activity
MAK48_18595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MAK48_18610	COG5337	Spore coat protein CotH
MAK48_18620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MAK48_18630	COG0405	Gamma-glutamyltransferase
MAK48_18635	COG1522	sequence-specific DNA binding
MAK48_18640	COG2059	Chromate
MAK48_18645	COG2059	Chromate
MAK48_18655	COG0655	NAD(P)H dehydrogenase (quinone) activity
MAK48_18660	COG0583	DNA-binding transcription factor activity
MAK48_18675	COG5444	nuclease activity
MAK48_18695	COG3878	Protein conserved in bacteria
MAK48_18700	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MAK48_18705	COG4464	protein tyrosine phosphatase activity
MAK48_18710	COG0489	protein tyrosine kinase activity
MAK48_18715	COG3944	biosynthesis protein
MAK48_18725	COG4715	Zinc finger, swim domain protein
MAK48_18730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MAK48_18735	COG0561	phosphatase activity
MAK48_18740	COG1349	DNA-binding transcription factor activity
MAK48_18745	COG0629	single-stranded DNA binding
MAK48_18765	COG0745	RESPONSE REGULATOR receiver
MAK48_18765	COG2972	Histidine kinase
MAK48_18770	COG1970	mechanosensitive ion channel activity
MAK48_18775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MAK48_18780	COG0457	Tetratricopeptide repeat
MAK48_18785	COG4786	Flagellar basal body rod
MAK48_18790	COG4786	Flagellar basal body rod
MAK48_18795	COG1077	Cell shape determining protein MreB Mrl
MAK48_18800	COG1609	Transcriptional regulator
MAK48_18810	COG1846	Transcriptional regulator
MAK48_18815	COG2814	Major facilitator Superfamily
MAK48_18820	COG3420	alginic acid biosynthetic process
MAK48_18825	COG1953	Uracil, thiamine, allantoin
MAK48_18830	COG0477	Major facilitator Superfamily
MAK48_18835	COG1335	isochorismatase
MAK48_18845	COG0004	ammonium transporteR
MAK48_18850	COG0347	Belongs to the P(II) protein family
MAK48_18855	COG0671	phosphoesterase, PA-phosphatase related
MAK48_18865	COG0739	heme binding
MAK48_18870	COG1247	-acetyltransferase
MAK48_18890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MAK48_18895	COG0789	Transcriptional regulator
MAK48_18905	COG2910	NAD(P)H-binding
MAK48_18910	COG1959	2 iron, 2 sulfur cluster binding
MAK48_18915	COG0804	urea catabolic process
MAK48_18920	COG0832	Belongs to the urease beta subunit family
MAK48_18925	COG0831	urea catabolic process
MAK48_18940	COG3237	CsbD-like
MAK48_18945	COG1994	Peptidase M50
MAK48_18950	COG0457	Tetratricopeptide repeat
MAK48_18955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MAK48_18960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MAK48_18970	COG2304	oxidoreductase activity
MAK48_18980	COG2304	oxidoreductase activity
MAK48_18985	COG2385	sporulation resulting in formation of a cellular spore
MAK48_18990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MAK48_19000	COG4836	Membrane
MAK48_19010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MAK48_19015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MAK48_19020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MAK48_19025	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MAK48_19030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MAK48_19035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MAK48_19045	COG0356	it plays a direct role in the translocation of protons across the membrane
MAK48_19055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MAK48_19060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MAK48_19065	COG4475	Protein of unknown function (DUF436)
MAK48_19070	COG0698	ribose 5-phosphate isomerase
MAK48_19075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MAK48_19080	COG1971	Probably functions as a manganese efflux pump
MAK48_19085	COG0009	L-threonylcarbamoyladenylate synthase
MAK48_19090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MAK48_19110	COG2890	protein-(glutamine-N5) methyltransferase activity
MAK48_19115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MAK48_19120	COG0346	lactoylglutathione lyase activity
MAK48_19125	COG0789	Transcriptional regulator
MAK48_19130	COG0679	Auxin Efflux Carrier
MAK48_19135	COG0281	malic enzyme
MAK48_19140	COG1435	thymidine kinase activity
MAK48_19150	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MAK48_19160	COG1494	fructose-1,6-bisphosphatase
MAK48_19165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MAK48_19170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MAK48_19175	COG0191	fructose-bisphosphate aldolase activity
MAK48_19180	COG2204	response regulator
MAK48_19185	COG4821	SIS domain
MAK48_19190	COG0504	CTP synthase activity
MAK48_19195	COG3343	RNA polymerase activity
MAK48_19200	COG1960	acyl-CoA dehydrogenase activity
MAK48_19205	COG0247	lactate metabolic process
MAK48_19205	COG2181	nitrate reductase activity
MAK48_19210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MAK48_19215	COG4294	response to UV
MAK48_19225	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MAK48_19230	COG1132	(ABC) transporter
MAK48_19235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MAK48_19245	COG2181	nitrate reductase activity
MAK48_19250	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MAK48_19255	COG1140	nitrate reductase beta subunit
MAK48_19260	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MAK48_19265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MAK48_19275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MAK48_19280	COG2223	nitrite transmembrane transporter activity
MAK48_19285	COG0018	arginyl-trna synthetase
MAK48_19290	COG4506	Protein conserved in bacteria
MAK48_19305	COG0535	radical SAM domain protein
MAK48_19315	COG1131	(ABC) transporter
MAK48_19320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MAK48_19325	COG0612	Peptidase, M16
MAK48_19330	COG0612	Peptidase, M16
MAK48_19340	COG3391	amine dehydrogenase activity
MAK48_19345	COG3391	amine dehydrogenase activity
MAK48_19350	COG0457	Tetratricopeptide repeat
MAK48_19360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MAK48_19365	COG0010	Belongs to the arginase family
MAK48_19370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MAK48_19375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MAK48_19385	COG1994	Peptidase M50
MAK48_19390	COG1942	4-Oxalocrotonate Tautomerase
MAK48_19395	COG1846	Transcriptional regulator
MAK48_19400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MAK48_19405	COG0477	Major facilitator Superfamily
MAK48_19410	COG1959	2 iron, 2 sulfur cluster binding
MAK48_19415	COG3465	dGTPase activity
MAK48_19420	COG1078	dGTPase activity
MAK48_19425	COG4844	belongs to the
MAK48_19435	COG0697	spore germination
MAK48_19440	COG0095	Lipoate-protein ligase
MAK48_19445	COG0583	DNA-binding transcription factor activity
MAK48_19450	COG0280	phosphate acetyltransferase
MAK48_19455	COG3253	May function as heme-dependent peroxidase
MAK48_19460	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_19465	COG0436	Aminotransferase
MAK48_19470	COG2814	Major facilitator Superfamily
MAK48_19475	COG0151	Belongs to the GarS family
MAK48_19480	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_19485	COG1917	Cupin 2, conserved barrel domain protein
MAK48_19490	COG0077	Prephenate dehydratase
MAK48_19495	COG2814	Major facilitator Superfamily
MAK48_19500	COG0833	amino acid
MAK48_19505	COG4187	Peptidase family M20/M25/M40
MAK48_19510	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_19515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MAK48_19525	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MAK48_19530	COG1091	dTDP-4-dehydrorhamnose reductase activity
MAK48_19535	COG1088	dTDP-glucose 4,6-dehydratase activity
MAK48_19540	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MAK48_19545	COG3980	spore coat polysaccharide biosynthesis protein
MAK48_19550	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
MAK48_19555	COG2089	acid synthase
MAK48_19560	COG0456	acetyltransferase
MAK48_19565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MAK48_19570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MAK48_19575	COG0463	Glycosyl transferase, family 2
MAK48_19585	COG2363	Small membrane protein
MAK48_19590	COG2233	PERMEase
MAK48_19600	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_19605	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MAK48_19610	COG1216	Glycosyl transferase, family 2
MAK48_19625	COG1695	Transcriptional regulator
MAK48_19630	COG0351	phosphomethylpyrimidine kinase
MAK48_19640	COG1621	beta-fructofuranosidase activity
MAK48_19645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_19645	COG1263	PTS System
MAK48_19650	COG2116	formate transmembrane transporter activity
MAK48_19655	COG3711	transcriptional antiterminator
MAK48_19665	COG1404	Belongs to the peptidase S8 family
MAK48_19670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_19675	COG0778	Nitroreductase
MAK48_19680	COG0772	Belongs to the SEDS family
MAK48_19690	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MAK48_19695	COG1845	cytochrome c oxidase, subunit III
MAK48_19700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MAK48_19705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MAK48_19710	COG2261	transglycosylase associated protein
MAK48_19715	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MAK48_19720	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MAK48_19725	COG2246	polysaccharide biosynthetic process
MAK48_19730	COG1309	transcriptional regulator
MAK48_19740	COG3162	membrane
MAK48_19745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MAK48_19750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MAK48_19755	COG2837	iron assimilation
MAK48_19760	COG2822	iron ion transport
MAK48_19765	COG0672	)-iron permease
MAK48_19770	COG0352	thiamine-phosphate diphosphorylase activity
MAK48_19775	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MAK48_19780	COG0583	DNA-binding transcription factor activity
MAK48_19785	COG1380	Effector of murein hydrolase LrgA
MAK48_19790	COG1346	cytolysis
MAK48_19795	COG2814	Major facilitator Superfamily
MAK48_19800	COG4895	conserved protein (DUF2196)
MAK48_19805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MAK48_19810	COG0346	lactoylglutathione lyase activity
MAK48_19825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MAK48_19830	COG1404	Belongs to the peptidase S8 family
MAK48_19835	COG1263	PTS System
MAK48_19835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_19840	COG3711	transcriptional antiterminator
MAK48_19845	COG1442	glycosyl transferase family 8
MAK48_19850	COG5522	Integral membrane protein (intg_mem_TP0381)
MAK48_19855	COG1846	Transcriptional regulator
MAK48_19860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MAK48_19865	COG2234	aminopeptidase activity
MAK48_19870	COG2357	RelA SpoT domain protein
MAK48_19875	COG1575	Belongs to the MenA family. Type 1 subfamily
MAK48_19890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MAK48_19895	COG1696	Membrane protein involved in D-alanine export
MAK48_19900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MAK48_19905	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MAK48_19910	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MAK48_19915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MAK48_19920	COG1486	melibiose metabolic process
MAK48_19925	COG1447	Phosphotransferase system cellobiose-specific component IIA
MAK48_19930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MAK48_19935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MAK48_19940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MAK48_19940	COG3711	transcriptional antiterminator
MAK48_19950	COG2094	Belongs to the DNA glycosylase MPG family
MAK48_19955	COG0753	catalase activity
MAK48_19960	COG2814	Major facilitator Superfamily
MAK48_19965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MAK48_19970	COG1131	(ABC) transporter
MAK48_19990	COG1595	DNA-templated transcription, initiation
MAK48_19995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MAK48_20000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MAK48_20005	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MAK48_20010	COG4988	ABC transporter
MAK48_20015	COG1294	oxidase, subunit
MAK48_20020	COG1271	oxidase subunit
MAK48_20025	COG3493	citrate carrier protein
MAK48_20030	COG0501	Belongs to the peptidase M48B family
MAK48_20040	COG0726	polysaccharide deacetylase
MAK48_20045	COG3842	ATPase activity
MAK48_20050	COG2508	Transcriptional regulator
MAK48_20055	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_20060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MAK48_20070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MAK48_20080	COG4585	Histidine kinase
MAK48_20085	COG2197	response regulator
MAK48_20090	COG2195	Cleaves the N-terminal amino acid of tripeptides
MAK48_20100	COG4894	glucomannan catabolic process
MAK48_20105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MAK48_20110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MAK48_20115	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_20120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MAK48_20125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MAK48_20130	COG2610	gluconate transmembrane transporter activity
MAK48_20135	COG0500	methyltransferase
MAK48_20140	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MAK48_20155	COG0693	protein deglycase activity
MAK48_20155	COG0753	catalase activity
MAK48_20160	COG2851	Citrate transporter
MAK48_20165	COG2273	Hydrolase Family 16
MAK48_20170	COG3711	transcriptional antiterminator
MAK48_20180	COG2270	Major facilitator Superfamily
MAK48_20185	COG0513	Belongs to the DEAD box helicase family
MAK48_20190	COG2755	lipolytic protein G-D-S-L family
MAK48_20190	COG3401	FG-GAP repeat protein
MAK48_20245	COG3209	COG3209 Rhs family protein
MAK48_20250	COG0697	spore germination
MAK48_20255	COG0589	response to stress
MAK48_20260	COG2723	6-phospho-beta-galactosidase activity
MAK48_20265	COG2190	(PTS) system
MAK48_20265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_20265	COG1263	PTS System
MAK48_20280	COG5444	nuclease activity
MAK48_20295	COG3507	Belongs to the glycosyl hydrolase 43 family
MAK48_20310	COG2986	histidine ammonia-lyase
MAK48_20315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MAK48_20320	COG1228	amidohydrolase
MAK48_20325	COG0010	Belongs to the arginase family
MAK48_20330	COG0833	amino acid
MAK48_20335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MAK48_20340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MAK48_20345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MAK48_20350	COG2390	Transcriptional regulator
MAK48_20360	COG3192	ethanolamine utilization protein
MAK48_20365	COG2079	MmgE PrpD family protein
MAK48_20370	COG1473	amidohydrolase
MAK48_20375	COG1126	abc transporter atp-binding protein
MAK48_20380	COG0765	amino acid transport
MAK48_20385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MAK48_20390	COG0456	acetyltransferase
MAK48_20395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MAK48_20405	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MAK48_20410	COG0561	phosphatase activity
MAK48_20440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MAK48_20445	COG5294	Protein conserved in bacteria
MAK48_20450	COG0577	efflux transmembrane transporter activity
MAK48_20455	COG1136	(ABC) transporter
MAK48_20460	COG2205	protein histidine kinase activity
MAK48_20465	COG0745	RESPONSE REGULATOR receiver
MAK48_20470	COG0191	fructose-bisphosphate aldolase activity
MAK48_20475	COG1082	Xylose isomerase domain protein TIM barrel
MAK48_20480	COG1082	Xylose isomerase domain protein TIM barrel
MAK48_20485	COG0673	inositol 2-dehydrogenase activity
MAK48_20490	COG2814	Major facilitator Superfamily
MAK48_20495	COG1082	Xylose isomerase domain protein TIM barrel
MAK48_20500	COG3962	Belongs to the TPP enzyme family
MAK48_20505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MAK48_20510	COG3718	enzyme involved in inositol metabolism
MAK48_20515	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_20520	COG1349	DNA-binding transcription factor activity
MAK48_20525	COG0667	Aldo Keto reductase
MAK48_20540	COG2814	Major facilitator Superfamily
MAK48_20545	COG0326	Molecular chaperone. Has ATPase activity
MAK48_20555	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_20560	COG1309	transcriptional regulator
MAK48_20565	COG1012	belongs to the aldehyde dehydrogenase family
MAK48_20570	COG0456	acetyltransferase
MAK48_20575	COG2850	peptidyl-arginine hydroxylation
MAK48_20580	COG2226	methyltransferase
MAK48_20595	COG0367	asparagine synthase
MAK48_20600	COG2814	Major facilitator Superfamily
MAK48_20605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MAK48_20615	COG1714	RDD family
MAK48_20620	COG2311	Membrane
MAK48_20625	COG1917	Cupin 2, conserved barrel domain protein
MAK48_20630	COG1309	transcriptional regulator
MAK48_20635	COG1028	Short-chain dehydrogenase reductase Sdr
MAK48_20640	COG1846	Transcriptional regulator
MAK48_20645	COG1380	Effector of murein hydrolase LrgA
MAK48_20650	COG1346	cytolysis
MAK48_20655	COG5039	Polysaccharide pyruvyl transferase
MAK48_20660	COG1929	Belongs to the glycerate kinase type-1 family
MAK48_20665	COG1802	Transcriptional regulator
MAK48_20670	COG1070	Carbohydrate kinase
MAK48_20675	COG2610	gluconate transmembrane transporter activity
MAK48_20680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MAK48_20685	COG0450	alkyl hydroperoxide reductase
MAK48_20690	COG3634	alkyl hydroperoxide reductase activity
MAK48_20695	COG2723	6-phospho-beta-galactosidase activity
MAK48_20705	COG2190	(PTS) system
MAK48_20705	COG1263	PTS System
MAK48_20705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MAK48_20710	COG2188	Transcriptional regulator
MAK48_20725	COG1131	(ABC) transporter
MAK48_20730	COG1994	Peptidase M50
MAK48_20735	COG0535	radical SAM domain protein
MAK48_20745	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MAK48_20750	COG5293	efflux transmembrane transporter activity
MAK48_20760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MAK48_20765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MAK48_20780	COG1063	alcohol dehydrogenase
MAK48_20800	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MAK48_20805	COG0456	acetyltransferase
MAK48_20810	COG0457	Tetratricopeptide repeat
MAK48_20820	COG0010	Belongs to the arginase family
MAK48_20825	COG0833	amino acid
MAK48_20830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MAK48_20835	COG3829	transcription factor binding
MAK48_20840	COG5002	protein histidine kinase activity
MAK48_20845	COG0745	RESPONSE REGULATOR receiver
MAK48_20865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MAK48_20870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MAK48_20875	COG4853	Protein conserved in bacteria
MAK48_20880	COG4863	YycH protein
MAK48_20885	COG5002	protein histidine kinase activity
MAK48_20890	COG0745	RESPONSE REGULATOR receiver
MAK48_20920	COG0346	lactoylglutathione lyase activity
MAK48_20925	COG0305	Participates in initiation and elongation during chromosome replication
MAK48_20940	COG3093	addiction module antidote protein HigA
MAK48_20945	COG2807	transmembrane transport
MAK48_20950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MAK48_20955	COG0359	binds to the 23S rRNA
MAK48_20960	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MAK48_20965	COG4241	membrane
MAK48_20975	COG5577	PFAM Coat F domain
MAK48_20980	COG1733	regulation of RNA biosynthetic process
MAK48_20985	COG1227	inorganic diphosphatase activity
MAK48_20995	COG2271	Major facilitator Superfamily
MAK48_21000	COG4978	Transcriptional regulator
MAK48_21000	COG0789	Transcriptional regulator
MAK48_21010	COG4319	ketosteroid isomerase
MAK48_21015	COG1357	PFAM Pentapeptide repeats (8 copies)
MAK48_21020	COG2814	Major facilitator Superfamily
MAK48_21025	COG0583	DNA-binding transcription factor activity
MAK48_21030	COG2153	protein acetylation
MAK48_21045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MAK48_21050	COG1846	Transcriptional regulator
MAK48_21055	COG2153	protein acetylation
MAK48_21060	COG2364	Membrane
MAK48_21065	COG0456	acetyltransferase
MAK48_21070	COG2315	Protein conserved in bacteria
MAK48_21075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MAK48_21085	COG2814	Major facilitator Superfamily
MAK48_21090	COG1331	Highly conserved protein containing a thioredoxin domain
MAK48_21095	COG1266	CAAX protease self-immunity
MAK48_21100	COG0477	Major facilitator Superfamily
MAK48_21100	COG2814	Major facilitator Superfamily
MAK48_21105	COG0110	maltose O-acetyltransferase activity
MAK48_21110	COG0346	lactoylglutathione lyase activity
MAK48_21115	COG1609	Transcriptional regulator
MAK48_21120	COG0708	Exodeoxyribonuclease III
MAK48_21125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MAK48_21130	COG0629	single-stranded DNA binding
MAK48_21135	COG0360	Binds together with S18 to 16S ribosomal RNA
MAK48_21140	COG0012	GTP binding
MAK48_21145	COG0243	molybdopterin cofactor binding
MAK48_21150	COG4481	Protein conserved in bacteria
MAK48_21155	COG3949	Membrane
MAK48_21165	COG1475	DNA binding
MAK48_21170	COG1192	Involved in chromosome partitioning
MAK48_21180	COG1475	DNA binding
MAK48_21185	COG0357	Ribosomal RNA small subunit methyltransferase G
MAK48_21190	COG0445	tRNA wobble uridine modification
MAK48_21195	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MAK48_21200	COG1847	R3H domain protein
MAK48_21205	COG0706	membrane insertase activity
MAK48_21210	COG0594	ribonuclease P activity