locus-tag	class	description
KPL74_00010	COG0784	Response regulator, receiver
KPL74_00010	COG4191	Histidine kinase
KPL74_00030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KPL74_00060	COG0004	ammonium transporteR
KPL74_00080	COG2853	Lipoprotein
KPL74_00100	COG0719	Fe-S assembly protein
KPL74_00110	COG0396	ATPase activity
KPL74_00115	COG0719	Fe-S assembly protein
KPL74_00120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KPL74_00130	COG2146	nitrite reductase [NAD(P)H] activity
KPL74_00145	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KPL74_00150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KPL74_00170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KPL74_00190	COG0583	DNA-binding transcription factor activity
KPL74_00205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KPL74_00210	COG4999	Histidine kinase
KPL74_00210	COG3850	Histidine kinase
KPL74_00210	COG3437	response regulator, receiver
KPL74_00210	COG2205	protein histidine kinase activity
KPL74_00240	COG0626	cystathionine gamma-synthase activity
KPL74_00245	COG0460	homoserine dehydrogenase
KPL74_00245	COG0527	aspartate kinase activity
KPL74_00250	COG0642	Histidine kinase
KPL74_00255	COG0745	RESPONSE REGULATOR receiver
KPL74_00275	COG0531	amino acid
KPL74_00285	COG1760	l-serine dehydratase
KPL74_00300	COG2353	YceI-like domain
KPL74_00305	COG3038	cytochrome b561
KPL74_00325	COG0795	lipopolysaccharide-transporting ATPase activity
KPL74_00335	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KPL74_00350	COG1199	ATP-dependent helicase activity
KPL74_00355	COG4452	Inner membrane protein CreD
KPL74_00360	COG1214	PFAM Peptidase M22, glycoprotease
KPL74_00420	COG2076	Multidrug Resistance protein
KPL74_00460	COG1477	protein flavinylation
KPL74_00470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KPL74_00490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KPL74_00505	COG0521	Mo-molybdopterin cofactor biosynthetic process
KPL74_00505	COG0315	cyclic pyranopterin monophosphate synthase activity
KPL74_00510	COG0303	'Molybdopterin
KPL74_00530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KPL74_00535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KPL74_00540	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KPL74_00545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KPL74_00555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KPL74_00560	COG0575	Belongs to the CDS family
KPL74_00565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KPL74_00580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KPL74_00585	COG0052	Belongs to the universal ribosomal protein uS2 family
KPL74_00590	COG0024	Methionine aminopeptidase
KPL74_00595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KPL74_00600	COG2171	N-acyltransferase activity
KPL74_00605	COG1393	Belongs to the ArsC family
KPL74_00610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KPL74_00635	COG2267	carboxylic ester hydrolase activity
KPL74_00675	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KPL74_00680	COG1194	a g-specific adenine glycosylase
KPL74_00690	COG0552	protein localization to endoplasmic reticulum
KPL74_00695	COG0742	ribosomal rna small subunit methyltransferase
KPL74_00700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KPL74_00710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPL74_00730	COG3788	relative of glutathione S-transferase, MAPEG superfamily
KPL74_00735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KPL74_00760	COG0784	Response regulator, receiver
KPL74_00760	COG0835	chemotaxis
KPL74_00765	COG1815	bacterial-type flagellum-dependent cell motility
KPL74_00780	COG1749	Flagellar hook protein flgE
KPL74_00785	COG4787	bacterial-type flagellum-dependent cell motility
KPL74_00795	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KPL74_00805	COG3951	Flagellar rod assembly protein muramidase FlgJ
KPL74_00805	COG1705	Flagellar rod assembly protein muramidase FlgJ
KPL74_00810	COG1256	bacterial-type flagellum assembly
KPL74_00830	COG1516	flagellar protein fliS
KPL74_00850	COG1677	Flagellar hook-basal body complex protein FliE
KPL74_00860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KPL74_00910	COG1987	bacterial-type flagellum assembly
KPL74_00925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KPL74_00950	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KPL74_00955	COG0643	Histidine kinase
KPL74_00955	COG2198	Histidine kinase
KPL74_00955	COG0784	Response regulator, receiver
KPL74_00960	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KPL74_00965	COG1360	Flagellar Motor Protein
KPL74_00970	COG1192	Involved in chromosome partitioning
KPL74_01000	COG2911	Protein conserved in bacteria
KPL74_01005	COG0729	surface antigen
KPL74_01010	COG0463	Glycosyl transferase, family 2
KPL74_01010	COG1216	Glycosyl transferase, family 2
KPL74_01015	COG0783	Belongs to the Dps family
KPL74_01020	COG1643	Atp-dependent helicase
KPL74_01025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KPL74_01035	COG0762	integral membrane protein
KPL74_01055	COG2823	Periplasmic or secreted lipoprotein
KPL74_01065	COG0540	Belongs to the ATCase OTCase family
KPL74_01090	COG0189	ligase activity
KPL74_01110	COG0840	transmembrane signaling receptor activity
KPL74_01115	COG2198	Histidine kinase
KPL74_01115	COG0643	Histidine kinase
KPL74_01115	COG0784	Response regulator, receiver
KPL74_01120	COG2201	protein-glutamate methylesterase activity
KPL74_01145	COG1136	(ABC) transporter
KPL74_01150	COG0577	efflux transmembrane transporter activity
KPL74_01150	COG1136	(ABC) transporter
KPL74_01155	COG0577	efflux transmembrane transporter activity
KPL74_01160	COG0577	efflux transmembrane transporter activity
KPL74_01165	COG0577	efflux transmembrane transporter activity
KPL74_01170	COG1136	(ABC) transporter
KPL74_01170	COG0577	efflux transmembrane transporter activity
KPL74_01175	COG0577	efflux transmembrane transporter activity
KPL74_01180	COG2204	response regulator
KPL74_01185	COG4191	Histidine kinase
KPL74_01185	COG2205	protein histidine kinase activity
KPL74_01185	COG0745	RESPONSE REGULATOR receiver
KPL74_01190	COG0330	HflC and HflK could
KPL74_01205	COG1942	4-Oxalocrotonate Tautomerase
KPL74_01215	COG0442	prolyl-tRNA aminoacylation
KPL74_01225	COG1183	phosphatidylcholine synthase activity
KPL74_01245	COG4181	ATPase activity
KPL74_01255	COG0745	RESPONSE REGULATOR receiver
KPL74_01260	COG5002	protein histidine kinase activity
KPL74_01275	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KPL74_01290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KPL74_01295	COG1704	LemA family
KPL74_01335	COG1902	pentaerythritol trinitrate reductase activity
KPL74_01340	COG0583	DNA-binding transcription factor activity
KPL74_01350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KPL74_01355	COG0352	thiamine-phosphate diphosphorylase activity
KPL74_01370	COG0824	Thioesterase
KPL74_01375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KPL74_01385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KPL74_01390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KPL74_01395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KPL74_01410	COG0268	Binds directly to 16S ribosomal RNA
KPL74_01420	COG0196	riboflavin kinase activity
KPL74_01430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KPL74_01435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KPL74_01500	COG0646	methionine synthase
KPL74_01500	COG1410	methionine synthase
KPL74_01510	COG0640	Transcriptional regulator
KPL74_01515	COG1960	acyl-CoA dehydrogenase activity
KPL74_01525	COG4771	TonB-dependent receptor
KPL74_01530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPL74_01535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPL74_01545	COG2902	Dehydrogenase
KPL74_01565	COG0697	spore germination
KPL74_01570	COG1960	acyl-CoA dehydrogenase activity
KPL74_01590	COG3706	GGDEF domain
KPL74_01600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KPL74_01605	COG0167	dihydroorotate dehydrogenase activity
KPL74_01615	COG1012	belongs to the aldehyde dehydrogenase family
KPL74_01625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KPL74_01640	COG1596	polysaccharide export
KPL74_01655	COG3206	protein involved in exopolysaccharide biosynthesis
KPL74_01655	COG0489	protein tyrosine kinase activity
KPL74_01660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KPL74_01700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KPL74_01715	COG0484	heat shock protein binding
KPL74_01755	COG1196	nuclear chromosome segregation
KPL74_01795	COG3546	catalase activity
KPL74_01800	COG3685	Protein conserved in bacteria
KPL74_01805	COG3685	Protein conserved in bacteria
KPL74_01845	COG3665	Urea carboxylase-associated protein
KPL74_02005	COG1012	belongs to the aldehyde dehydrogenase family
KPL74_02010	COG1570	exodeoxyribonuclease VII activity
KPL74_02015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KPL74_02035	COG1960	acyl-CoA dehydrogenase activity
KPL74_02040	COG1289	transmembrane transporter activity
KPL74_02050	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_02065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KPL74_02070	COG0204	Acyl-transferase
KPL74_02080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KPL74_02100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KPL74_02135	COG1703	isobutyryl-CoA mutase activity
KPL74_02135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KPL74_02135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KPL74_02195	COG3387	PFAM Glycoside hydrolase 15-related
KPL74_02225	COG1253	flavin adenine dinucleotide binding
KPL74_02235	COG2321	neutral zinc metallopeptidase
KPL74_02245	COG1404	Belongs to the peptidase S8 family
KPL74_02260	COG0745	RESPONSE REGULATOR receiver
KPL74_02270	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KPL74_02275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KPL74_02280	COG0513	Belongs to the DEAD box helicase family
KPL74_02295	COG2814	Major facilitator Superfamily
KPL74_02300	COG1047	Peptidyl-prolyl cis-trans
KPL74_02315	COG1764	response to oxidative stress
KPL74_02320	COG0791	NLP P60 protein
KPL74_02360	COG0017	Asparaginyl-tRNA synthetase
KPL74_02365	COG0316	Belongs to the HesB IscA family
KPL74_02370	COG0360	Binds together with S18 to 16S ribosomal RNA
KPL74_02375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KPL74_02390	COG0305	Participates in initiation and elongation during chromosome replication
KPL74_02430	COG0714	Associated with various cellular activities
KPL74_02440	COG3552	Protein containing von Willebrand factor type A (VWA) domain
KPL74_02450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KPL74_02460	COG4137	Cytochrome C assembly protein
KPL74_02465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KPL74_02470	COG0228	four-way junction DNA binding
KPL74_02475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KPL74_02480	COG0336	Belongs to the RNA methyltransferase TrmD family
KPL74_02485	COG0335	large ribosomal subunit rRNA binding
KPL74_02495	COG1509	lysine 2,3-aminomutase activity
KPL74_02500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KPL74_02505	COG0402	S-adenosylhomocysteine deaminase activity
KPL74_02525	COG1469	GTP cyclohydrolase I activity
KPL74_02530	COG0739	heme binding
KPL74_02535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KPL74_02540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KPL74_02560	COG1051	belongs to the nudix hydrolase family
KPL74_02560	COG1056	cytidyltransferase-related domain
KPL74_02570	COG2166	iron-sulfur cluster assembly
KPL74_02585	COG4953	penicillin-binding protein 1C
KPL74_02590	COG2373	Large extracellular alpha-helical protein
KPL74_02600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KPL74_02605	COG0137	argininosuccinate synthase activity
KPL74_02610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KPL74_02615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KPL74_02620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KPL74_02625	COG0165	Argininosuccinate lyase
KPL74_02630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KPL74_02645	COG0477	Major facilitator Superfamily
KPL74_02675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KPL74_02690	COG0456	acetyltransferase
KPL74_02705	COG1047	Peptidyl-prolyl cis-trans
KPL74_02720	COG3214	Protein conserved in bacteria
KPL74_02735	COG1278	Cold shock
KPL74_02745	COG1741	Belongs to the pirin family
KPL74_02755	COG0156	8-amino-7-oxononanoate synthase activity
KPL74_02775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KPL74_02780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPL74_02785	COG2827	Endonuclease containing a URI domain
KPL74_02820	COG1555	photosystem II stabilization
KPL74_02820	COG1596	polysaccharide export
KPL74_02835	COG1388	LysM domain
KPL74_02835	COG3103	Sh3 type 3 domain protein
KPL74_02835	COG0791	NLP P60 protein
KPL74_02850	COG0156	8-amino-7-oxononanoate synthase activity
KPL74_02880	COG2020	methyltransferase activity
KPL74_02885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KPL74_02890	COG1923	regulation of RNA biosynthetic process
KPL74_02895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KPL74_02900	COG0330	HflC and HflK could
KPL74_02905	COG0330	HflC and HflK could
KPL74_02925	COG0285	dihydrofolate synthase activity
KPL74_02945	COG2833	Protein of unknown function (DUF455)
KPL74_02950	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KPL74_02960	COG0248	Ppx GppA phosphatase
KPL74_02970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KPL74_02975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KPL74_02985	COG0745	RESPONSE REGULATOR receiver
KPL74_03005	COG0473	3-isopropylmalate dehydrogenase activity
KPL74_03025	COG1530	ribonuclease E activity
KPL74_03030	COG0564	pseudouridine synthase activity
KPL74_03045	COG0316	Belongs to the HesB IscA family
KPL74_03045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KPL74_03065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPL74_03070	COG2957	Belongs to the agmatine deiminase family
KPL74_03080	COG0488	(ABC) transporter
KPL74_03090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KPL74_03100	COG3781	membrane
KPL74_03140	COG0697	spore germination
KPL74_03150	COG2814	Major facilitator Superfamily
KPL74_03155	COG0583	DNA-binding transcription factor activity
KPL74_03160	COG1946	Acyl-CoA thioesterase
KPL74_03175	COG0116	Belongs to the methyltransferase superfamily
KPL74_03175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KPL74_03190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPL74_03195	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KPL74_03200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KPL74_03215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KPL74_03230	COG0604	alcohol dehydrogenase
KPL74_03255	COG0697	spore germination
KPL74_03270	COG0583	DNA-binding transcription factor activity
KPL74_03285	COG1349	DNA-binding transcription factor activity
KPL74_03300	COG2222	sugar isomerase
KPL74_03305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KPL74_03335	COG0659	secondary active sulfate transmembrane transporter activity
KPL74_03345	COG0642	Histidine kinase
KPL74_03375	COG3059	membrane
KPL74_03390	COG2319	Wd-40 repeat
KPL74_03415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPL74_03430	COG1309	transcriptional regulator
KPL74_03435	COG0596	Alpha beta hydrolase
KPL74_03440	COG0667	Aldo Keto reductase
KPL74_03455	COG3706	GGDEF domain
KPL74_03495	COG3537	Alpha-1,2-mannosidase
KPL74_03505	COG3781	membrane
KPL74_03515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KPL74_03515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KPL74_03520	COG0300	oxidoreductase activity
KPL74_03560	COG1595	DNA-templated transcription, initiation
KPL74_03600	COG0557	exoribonuclease II activity
KPL74_03605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KPL74_03620	COG0704	Plays a role in the regulation of phosphate uptake
KPL74_03625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KPL74_03635	COG0573	inorganic phosphate transmembrane transporter activity
KPL74_03660	COG0288	reversible hydration of carbon dioxide
KPL74_03665	COG0659	secondary active sulfate transmembrane transporter activity
KPL74_03670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KPL74_03675	COG2878	Part of a membrane complex involved in electron transport
KPL74_03680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPL74_03680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPL74_03690	COG0489	protein tyrosine kinase activity
KPL74_03695	COG0717	Belongs to the dCTP deaminase family
KPL74_03710	COG0412	Dienelactone hydrolase
KPL74_03720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KPL74_03730	COG2197	response regulator
KPL74_03735	COG2205	protein histidine kinase activity
KPL74_03735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KPL74_03740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KPL74_03750	COG0433	COG0433 Predicted ATPase
KPL74_03785	COG1349	DNA-binding transcription factor activity
KPL74_03795	COG3842	ATPase activity
KPL74_03800	COG1840	ABC-type Fe3 transport system, periplasmic component
KPL74_03825	COG2890	protein-(glutamine-N5) methyltransferase activity
KPL74_03830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KPL74_03835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KPL74_03840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KPL74_03855	COG0101	tRNA pseudouridine synthase activity
KPL74_03870	COG0159	tryptophan synthase activity
KPL74_03880	COG0671	phosphoesterase, PA-phosphatase related
KPL74_03900	COG0735	belongs to the Fur family
KPL74_03915	COG1230	cation diffusion facilitator family transporter
KPL74_03935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KPL74_03965	COG1228	amidohydrolase
KPL74_03975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPL74_03975	COG3153	acetyltransferase
KPL74_03995	COG0367	asparagine synthase
KPL74_04000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KPL74_04015	COG2350	Protein conserved in bacteria
KPL74_04035	COG0366	Alpha amylase catalytic
KPL74_04040	COG0366	Alpha amylase catalytic
KPL74_04045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KPL74_04055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KPL74_04060	COG1640	4-alpha-glucanotransferase
KPL74_04075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KPL74_04080	COG0539	negative regulation of cytoplasmic translation
KPL74_04085	COG0776	regulation of translation
KPL74_04095	COG0415	Belongs to the DNA photolyase family
KPL74_04100	COG0475	glutathione-regulated potassium exporter activity
KPL74_04105	COG0477	Major facilitator Superfamily
KPL74_04120	COG0346	lactoylglutathione lyase activity
KPL74_04130	COG2925	Exonuclease
KPL74_04135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KPL74_04140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KPL74_04165	COG2982	Protein involved in outer membrane biogenesis
KPL74_04260	COG2375	cellular response to nickel ion
KPL74_04265	COG1695	Transcriptional regulator
KPL74_04280	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
KPL74_04305	COG0564	pseudouridine synthase activity
KPL74_04310	COG0477	Major facilitator Superfamily
KPL74_04315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KPL74_04325	COG0492	ferredoxin-NADP+ reductase activity
KPL74_04330	COG0686	Belongs to the AlaDH PNT family
KPL74_04335	COG1674	ftsk spoiiie
KPL74_04345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KPL74_04365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KPL74_04380	COG3708	Transcriptional regulator
KPL74_04380	COG2207	Transcriptional regulator
KPL74_04395	COG0702	epimerase
KPL74_04485	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KPL74_04490	COG0753	catalase activity
KPL74_04495	COG2197	response regulator
KPL74_04515	COG4585	Histidine kinase
KPL74_04520	COG0596	Alpha beta hydrolase
KPL74_04525	COG2205	protein histidine kinase activity
KPL74_04550	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_04555	COG0583	DNA-binding transcription factor activity
KPL74_04640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KPL74_04640	COG2755	lipolytic protein G-D-S-L family
KPL74_04660	COG2814	Major facilitator Superfamily
KPL74_04675	COG2197	response regulator
KPL74_04685	COG1335	isochorismatase
KPL74_04695	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KPL74_04775	COG0038	chloride channel
KPL74_04800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KPL74_04820	COG1063	alcohol dehydrogenase
KPL74_04830	COG3387	PFAM Glycoside hydrolase 15-related
KPL74_04880	COG4585	Histidine kinase
KPL74_04885	COG0596	Alpha beta hydrolase
KPL74_04895	COG4208	sulfate ABC transporter
KPL74_04900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KPL74_04905	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KPL74_04950	COG2197	response regulator
KPL74_04965	COG2353	YceI-like domain
KPL74_04990	COG0753	catalase activity
KPL74_05000	COG2814	Major facilitator Superfamily
KPL74_05015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPL74_05035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPL74_05065	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_05075	COG3263	regulation of cellular component size
KPL74_05105	COG0625	glutathione transferase activity
KPL74_05110	COG2226	methyltransferase
KPL74_05110	COG2267	carboxylic ester hydrolase activity
KPL74_05115	COG0583	DNA-binding transcription factor activity
KPL74_05155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KPL74_05160	COG0701	Predicted permease
KPL74_05165	COG0709	Synthesizes selenophosphate from selenide and ATP
KPL74_05175	COG3276	selenocysteine insertion sequence binding
KPL74_05180	COG1921	L-seryl-tRNASec selenium transferase activity
KPL74_05185	COG3058	Necessary for formate dehydrogenase activity
KPL74_05190	COG2864	formate dehydrogenase
KPL74_05195	COG0437	4 iron, 4 sulfur cluster binding
KPL74_05200	COG0243	molybdopterin cofactor binding
KPL74_05200	COG3383	formate dehydrogenase (NAD+) activity
KPL74_05205	COG0243	molybdopterin cofactor binding
KPL74_05205	COG3383	formate dehydrogenase (NAD+) activity
KPL74_05220	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_05240	COG1309	transcriptional regulator
KPL74_05245	COG5001	Diguanylate cyclase
KPL74_05255	COG0708	Exodeoxyribonuclease III
KPL74_05265	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_05280	COG1275	C4-dicarboxylate transporter malic acid transport protein
KPL74_05295	COG0531	amino acid
KPL74_05305	COG1486	melibiose metabolic process
KPL74_05310	COG2367	Beta-lactamase
KPL74_05320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KPL74_05325	COG2201	protein-glutamate methylesterase activity
KPL74_05335	COG0583	DNA-binding transcription factor activity
KPL74_05360	COG0306	phosphate transporter
KPL74_05370	COG4115	mRNA cleavage
KPL74_05375	COG3781	membrane
KPL74_05450	COG1111	helicase
KPL74_05450	COG1205	dead DEAH box helicase
KPL74_05465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KPL74_05470	COG0583	DNA-binding transcription factor activity
KPL74_05475	COG0436	Aminotransferase
KPL74_05480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPL74_05490	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
KPL74_05495	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KPL74_05500	COG0235	Class ii aldolase
KPL74_05510	COG0531	amino acid
KPL74_05515	COG0531	amino acid
KPL74_05530	COG0662	Cupin 2, conserved barrel domain protein
KPL74_05540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPL74_05545	COG0183	Belongs to the thiolase family
KPL74_05550	COG1024	Enoyl-CoA hydratase
KPL74_05550	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPL74_05560	COG0105	UTP biosynthetic process
KPL74_05565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KPL74_05585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KPL74_05590	COG1160	GTP binding
KPL74_05595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KPL74_05605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KPL74_05615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KPL74_05615	COG0519	Catalyzes the synthesis of GMP from XMP
KPL74_05640	COG2226	methyltransferase
KPL74_05695	COG2207	Transcriptional regulator
KPL74_05705	COG0667	Aldo Keto reductase
KPL74_05710	COG1902	pentaerythritol trinitrate reductase activity
KPL74_05720	COG0519	Catalyzes the synthesis of GMP from XMP
KPL74_05735	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KPL74_05740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPL74_05750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KPL74_05760	COG2197	response regulator
KPL74_05770	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KPL74_05775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KPL74_05785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KPL74_05790	COG2972	Histidine kinase
KPL74_05795	COG3279	Response regulator of the LytR AlgR family
KPL74_05805	COG0546	phosphoglycolate phosphatase activity
KPL74_05810	COG1309	transcriptional regulator
KPL74_05835	COG1609	Transcriptional regulator
KPL74_05860	COG4969	Belongs to the N-Me-Phe pilin family
KPL74_05930	COG4993	Dehydrogenase
KPL74_05935	COG1609	Transcriptional regulator
KPL74_05945	COG0484	heat shock protein binding
KPL74_05975	COG3459	Glycosyltransferase 36 associated
KPL74_06010	COG1297	OPT oligopeptide transporter protein
KPL74_06015	COG0726	polysaccharide deacetylase
KPL74_06020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KPL74_06070	COG0300	oxidoreductase activity
KPL74_06080	COG4221	oxidoreductase activity
KPL74_06085	COG1012	belongs to the aldehyde dehydrogenase family
KPL74_06090	COG4977	sequence-specific DNA binding
KPL74_06110	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_06120	COG0596	Alpha beta hydrolase
KPL74_06130	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_06135	COG1733	regulation of RNA biosynthetic process
KPL74_06140	COG2133	pyrroloquinoline quinone binding
KPL74_06165	COG1902	pentaerythritol trinitrate reductase activity
KPL74_06210	COG0475	glutathione-regulated potassium exporter activity
KPL74_06210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KPL74_06220	COG0753	catalase activity
KPL74_06240	COG1902	pentaerythritol trinitrate reductase activity
KPL74_06245	COG2814	Major facilitator Superfamily
KPL74_06250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPL74_06265	COG0656	L-ascorbic acid biosynthetic process
KPL74_06275	COG4585	Histidine kinase
KPL74_06285	COG0745	RESPONSE REGULATOR receiver
KPL74_06290	COG0583	DNA-binding transcription factor activity
KPL74_06295	COG2197	response regulator
KPL74_06300	COG0583	DNA-binding transcription factor activity
KPL74_06325	COG2267	carboxylic ester hydrolase activity
KPL74_06330	COG1271	oxidase subunit
KPL74_06345	COG3789	protein conserved in bacteria
KPL74_06360	COG0583	DNA-binding transcription factor activity
KPL74_06375	COG0390	transport system, permease component
KPL74_06380	COG1136	(ABC) transporter
KPL74_06410	COG0583	DNA-binding transcription factor activity
KPL74_06425	COG0697	spore germination
KPL74_06470	COG2133	pyrroloquinoline quinone binding
KPL74_06485	COG3511	phospholipase C
KPL74_06490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KPL74_06495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KPL74_06500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KPL74_06520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KPL74_06530	COG2244	polysaccharide biosynthetic process
KPL74_06560	COG0456	acetyltransferase
KPL74_06570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPL74_06580	COG3275	phosphorelay sensor kinase activity
KPL74_06590	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_06620	COG0583	DNA-binding transcription factor activity
KPL74_06635	COG1301	dicarboxylic acid transport
KPL74_06660	COG3047	cAMP biosynthetic process
KPL74_06665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KPL74_06670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KPL74_06675	COG0018	arginyl-trna synthetase
KPL74_06680	COG1252	NADH dehydrogenase
KPL74_06685	COG0667	Aldo Keto reductase
KPL74_06695	COG2197	response regulator
KPL74_06700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KPL74_06710	COG2091	lysine biosynthetic process via aminoadipic acid
KPL74_06715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KPL74_06790	COG0438	transferase activity, transferring glycosyl groups
KPL74_06795	COG0438	transferase activity, transferring glycosyl groups
KPL74_06925	COG0656	L-ascorbic acid biosynthetic process
KPL74_06930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KPL74_06935	COG0427	acetyl-CoA hydrolase
KPL74_06970	COG0386	Belongs to the glutathione peroxidase family
KPL74_06980	COG2011	ABC-type metal ion transport system permease component
KPL74_07005	COG1301	dicarboxylic acid transport
KPL74_07020	COG0753	catalase activity
KPL74_07065	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KPL74_07080	COG0354	folic acid binding
KPL74_07100	COG0084	hydrolase, TatD family'
KPL74_07110	COG1538	Outer membrane efflux protein
KPL74_07115	COG1566	PFAM secretion protein HlyD family protein
KPL74_07120	COG2814	Major facilitator Superfamily
KPL74_07130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPL74_07145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KPL74_07165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KPL74_07175	COG4235	cytochrome complex assembly
KPL74_07175	COG3088	subunit of a heme lyase
KPL74_07180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KPL74_07210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPL74_07235	COG2095	MarC family integral membrane protein
KPL74_07240	COG1215	transferase activity, transferring glycosyl groups
KPL74_07255	COG0726	polysaccharide deacetylase
KPL74_07255	COG1649	PFAM Uncharacterised BCR, COG1649
KPL74_07260	COG1215	transferase activity, transferring glycosyl groups
KPL74_07270	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
KPL74_07280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KPL74_07290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KPL74_07325	COG2203	Gaf domain
KPL74_07325	COG3706	GGDEF domain
KPL74_07325	COG5001	Diguanylate cyclase
KPL74_07325	COG4251	negative regulation of phosphorylation
KPL74_07330	COG2304	oxidoreductase activity
KPL74_07370	COG1793	dna ligase
KPL74_07375	COG1201	RNA secondary structure unwinding
KPL74_07400	COG1446	asparaginase
KPL74_07420	COG1278	Cold shock
KPL74_07425	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KPL74_07430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KPL74_07435	COG1472	Belongs to the glycosyl hydrolase 3 family
KPL74_07445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KPL74_07495	COG1381	Involved in DNA repair and RecF pathway recombination
KPL74_07515	COG0681	Belongs to the peptidase S26 family
KPL74_07520	COG0481	GTPase activity
KPL74_07525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPL74_07550	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPL74_07550	COG1024	Enoyl-CoA hydratase
KPL74_07560	COG2900	Belongs to the SlyX family
KPL74_07575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KPL74_07575	COG4651	solute:proton antiporter activity
KPL74_07600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KPL74_07615	COG1011	Hydrolase
KPL74_07620	COG2223	nitrite transmembrane transporter activity
KPL74_07630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KPL74_07645	COG0587	DNA-directed DNA polymerase activity
KPL74_07670	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KPL74_07675	COG0583	DNA-binding transcription factor activity
KPL74_07700	COG2755	lipolytic protein G-D-S-L family
KPL74_07700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KPL74_07710	COG4191	Histidine kinase
KPL74_07710	COG0784	Response regulator, receiver
KPL74_07725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KPL74_07730	COG4771	TonB-dependent receptor
KPL74_07755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KPL74_07770	COG1752	Esterase of the alpha-beta hydrolase superfamily
KPL74_07855	COG0149	triose-phosphate isomerase activity
KPL74_07860	COG3264	Mechanosensitive ion channel
KPL74_07860	COG1511	domain protein
KPL74_07875	COG0024	Methionine aminopeptidase
KPL74_07885	COG1132	(ABC) transporter
KPL74_07900	COG0435	Glutathione S-transferase
KPL74_07905	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KPL74_07910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KPL74_07915	COG0039	L-malate dehydrogenase activity
KPL74_07925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KPL74_07940	COG2205	protein histidine kinase activity
KPL74_07950	COG4771	TonB-dependent receptor
KPL74_07955	COG2610	gluconate transmembrane transporter activity
KPL74_08010	COG1217	gtp-binding protein TYPA
KPL74_08030	COG0668	transmembrane transport
KPL74_08035	COG3663	DNA glycosylase
KPL74_08040	COG2010	Cytochrome c
KPL74_08040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KPL74_08050	COG0154	amidase activity
KPL74_08065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KPL74_08075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KPL74_08085	COG1663	tetraacyldisaccharide 4'-kinase activity
KPL74_08090	COG1132	(ABC) transporter
KPL74_08100	COG0811	peptide transport
KPL74_08105	COG4771	TonB-dependent receptor
KPL74_08125	COG2333	competence protein COMEC
KPL74_08125	COG0658	competence protein
KPL74_08145	COG0384	phenazine biosynthesis protein PhzF
KPL74_08165	COG2084	Dehydrogenase
KPL74_08170	COG2081	HI0933 family
KPL74_08175	COG1666	GTP binding
KPL74_08180	COG3706	GGDEF domain
KPL74_08190	COG0823	Involved in the tonB-independent uptake of proteins
KPL74_08190	COG1506	peptidase
KPL74_08190	COG4946	Tricorn protease homolog
KPL74_08200	COG1764	response to oxidative stress
KPL74_08205	COG0598	Magnesium transport protein CorA
KPL74_08220	COG2032	superoxide dismutase activity
KPL74_08225	COG1187	pseudouridine synthase activity
KPL74_08230	COG2813	Specifically methylates the guanine in position
KPL74_08240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KPL74_08255	COG1450	Type ii and iii secretion system protein
KPL74_08270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPL74_08275	COG0583	DNA-binding transcription factor activity
KPL74_08285	COG3706	GGDEF domain
KPL74_08300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KPL74_08305	COG0505	Belongs to the CarA family
KPL74_08320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KPL74_08325	COG0484	heat shock protein binding
KPL74_08330	COG0443	Heat shock 70 kDa protein
KPL74_08335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KPL74_08340	COG1420	regulation of RNA biosynthetic process
KPL74_08350	COG2197	response regulator
KPL74_08355	COG3851	Histidine kinase
KPL74_08365	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KPL74_08370	COG2914	Belongs to the UPF0125 (RnfH) family
KPL74_08380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KPL74_08405	COG3685	Protein conserved in bacteria
KPL74_08430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KPL74_08485	COG2267	carboxylic ester hydrolase activity
KPL74_08495	COG0596	Alpha beta hydrolase
KPL74_08570	COG3046	protein related to deoxyribodipyrimidine photolyase
KPL74_08580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KPL74_08600	COG1733	regulation of RNA biosynthetic process
KPL74_08605	COG3321	synthase
KPL74_08605	COG0604	alcohol dehydrogenase
KPL74_08610	COG0672	)-iron permease
KPL74_08620	COG1538	Outer membrane efflux protein
KPL74_08640	COG4774	siderophore transport
KPL74_08660	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_08665	COG0109	protoheme IX farnesyltransferase activity
KPL74_08670	COG0109	protoheme IX farnesyltransferase activity
KPL74_08685	COG1902	pentaerythritol trinitrate reductase activity
KPL74_08690	COG1845	cytochrome c oxidase, subunit III
KPL74_08695	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KPL74_08710	COG0183	Belongs to the thiolase family
KPL74_08725	COG2814	Major facilitator Superfamily
KPL74_08735	COG1999	signal sequence binding
KPL74_08955	COG0438	transferase activity, transferring glycosyl groups
KPL74_09125	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_09130	COG0583	DNA-binding transcription factor activity
KPL74_09145	COG2197	response regulator
KPL74_09150	COG1942	4-Oxalocrotonate Tautomerase
KPL74_09155	COG1902	pentaerythritol trinitrate reductase activity
KPL74_09165	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_09170	COG2267	carboxylic ester hydrolase activity
KPL74_09175	COG0583	DNA-binding transcription factor activity
KPL74_09190	COG0583	DNA-binding transcription factor activity
KPL74_09195	COG1902	pentaerythritol trinitrate reductase activity
KPL74_09235	COG1397	ADP-ribosylglycohydrolase
KPL74_09285	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KPL74_09290	COG3713	MltA-interacting MipA family protein
KPL74_09295	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_09300	COG0583	DNA-binding transcription factor activity
KPL74_09325	COG0583	DNA-binding transcription factor activity
KPL74_09340	COG2207	Transcriptional regulator
KPL74_09345	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_09365	COG3550	peptidyl-serine autophosphorylation
KPL74_09430	COG3275	phosphorelay sensor kinase activity
KPL74_09440	COG1619	proteins homologs of microcin C7 resistance protein MccF
KPL74_09465	COG4771	TonB-dependent receptor
KPL74_09485	COG1131	(ABC) transporter
KPL74_09520	COG2850	peptidyl-arginine hydroxylation
KPL74_09550	COG0604	alcohol dehydrogenase
KPL74_09570	COG0678	peroxiredoxin activity
KPL74_09575	COG0583	DNA-binding transcription factor activity
KPL74_09595	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KPL74_09600	COG3243	poly(R)-hydroxyalkanoic acid synthase
KPL74_09610	COG1472	Belongs to the glycosyl hydrolase 3 family
KPL74_09620	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_09625	COG1185	polyribonucleotide nucleotidyltransferase activity
KPL74_09630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KPL74_09635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KPL74_09640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KPL74_09645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KPL74_09650	COG0195	Participates in both transcription termination and antitermination
KPL74_09655	COG0779	Required for maturation of 30S ribosomal subunits
KPL74_09670	COG3549	Plasmid maintenance system killer
KPL74_09730	COG3682	Transcriptional regulator
KPL74_09745	COG1007	ATP synthesis coupled electron transport
KPL74_09760	COG0713	ATP synthesis coupled electron transport
KPL74_09775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KPL74_09780	COG1034	ATP synthesis coupled electron transport
KPL74_09790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KPL74_09795	COG0649	NAD binding
KPL74_09800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KPL74_09805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KPL74_09810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KPL74_09830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KPL74_09835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KPL74_09845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KPL74_09855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KPL74_09860	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_09870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KPL74_09875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KPL74_09900	COG0714	Associated with various cellular activities
KPL74_09920	COG0537	adenosine 5'-monophosphoramidase activity
KPL74_09925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KPL74_09930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KPL74_09935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KPL74_09955	COG3642	lipopolysaccharide core region biosynthetic process
KPL74_09960	COG0859	PFAM glycosyl transferase family 9
KPL74_09970	COG1914	H( )-stimulated, divalent metal cation uptake system
KPL74_09985	COG4191	Histidine kinase
KPL74_09990	COG1301	dicarboxylic acid transport
KPL74_10045	COG0631	protein serine/threonine phosphatase activity
KPL74_10055	COG0328	RNA-DNA hybrid ribonuclease activity
KPL74_10060	COG2226	methyltransferase
KPL74_10070	COG1388	LysM domain
KPL74_10070	COG1705	Flagellar rod assembly protein muramidase FlgJ
KPL74_10080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KPL74_10105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KPL74_10110	COG0740	serine-type endopeptidase activity
KPL74_10140	COG2194	sulfuric ester hydrolase activity
KPL74_10170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KPL74_10175	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KPL74_10180	COG1534	Rna-binding protein
KPL74_10190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KPL74_10210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KPL74_10225	COG2239	Acts as a magnesium transporter
KPL74_10240	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KPL74_10245	COG0148	phosphopyruvate hydratase activity
KPL74_10270	COG0166	Belongs to the GPI family
KPL74_10280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KPL74_10285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KPL74_10290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KPL74_10295	COG0617	tRNA 3'-terminal CCA addition
KPL74_10305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KPL74_10325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPL74_10335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KPL74_10340	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KPL74_10360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KPL74_10365	COG0840	transmembrane signaling receptor activity
KPL74_10420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KPL74_10425	COG0322	excinuclease ABC activity
KPL74_10430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KPL74_10440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KPL74_10445	COG1605	Chorismate mutase
KPL74_10445	COG0077	Prephenate dehydratase
KPL74_10450	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KPL74_10465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KPL74_10470	COG0740	serine-type endopeptidase activity
KPL74_10475	COG1595	DNA-templated transcription, initiation
KPL74_10480	COG0542	response to heat
KPL74_10485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KPL74_10490	COG0494	nUDIX hydrolase
KPL74_10495	COG0482	sulfurtransferase activity
KPL74_10500	COG2915	High frequency lysogenization protein hflD homolog
KPL74_10505	COG0583	DNA-binding transcription factor activity
KPL74_10525	COG0318	PFAM AMP-dependent synthetase and ligase
KPL74_10535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPL74_10540	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KPL74_10545	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KPL74_10555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KPL74_10555	COG0140	phosphoribosyl-ATP diphosphatase activity
KPL74_10565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KPL74_10570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KPL74_10580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KPL74_10585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KPL74_10590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KPL74_10600	COG2197	response regulator
KPL74_10605	COG2986	histidine ammonia-lyase
KPL74_10610	COG0124	histidyl-tRNA synthetase
KPL74_10660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KPL74_10670	COG2137	regulation of response to DNA damage stimulus
KPL74_10675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KPL74_10680	COG1546	Belongs to the CinA family
KPL74_10700	COG2948	multi-organism process
KPL74_10865	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KPL74_10890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KPL74_10915	COG5295	Hep Hag repeat protein
KPL74_10930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KPL74_11155	COG0326	Molecular chaperone. Has ATPase activity
KPL74_11160	COG0501	Belongs to the peptidase M48B family
KPL74_11165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KPL74_11170	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_11205	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KPL74_11210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KPL74_11215	COG0840	transmembrane signaling receptor activity
KPL74_11225	COG0643	Histidine kinase
KPL74_11225	COG2198	Histidine kinase
KPL74_11230	COG0745	RESPONSE REGULATOR receiver
KPL74_11240	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KPL74_11255	COG2197	response regulator
KPL74_11260	COG4585	Histidine kinase
KPL74_11265	COG4585	Histidine kinase
KPL74_11275	COG1131	(ABC) transporter
KPL74_11280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KPL74_11290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KPL74_11305	COG0277	FAD linked oxidase domain protein
KPL74_11310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KPL74_11315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPL74_11320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPL74_11325	COG3706	GGDEF domain
KPL74_11325	COG2203	Gaf domain
KPL74_11325	COG5001	Diguanylate cyclase
KPL74_11325	COG4251	negative regulation of phosphorylation
KPL74_11345	COG3345	alpha-galactosidase
KPL74_11365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPL74_11365	COG0072	phenylalanine-tRNA ligase activity
KPL74_11370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KPL74_11375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KPL74_11385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KPL74_11390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KPL74_11395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KPL74_11400	COG1074	ATP-dependent DNA helicase activity
KPL74_11405	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KPL74_11410	COG1981	membrane
KPL74_11430	COG0556	nucleotide-excision repair
KPL74_11475	COG1611	Belongs to the LOG family
KPL74_11495	COG2095	MarC family integral membrane protein
KPL74_11545	COG2969	positive regulation of protein catabolic process
KPL74_11550	COG0625	glutathione transferase activity
KPL74_11555	COG2857	Cytochrome c1
KPL74_11560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KPL74_11565	COG0723	plastoquinol--plastocyanin reductase activity
KPL74_11575	COG0741	lytic transglycosylase activity
KPL74_11580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KPL74_11585	COG1702	phosphate starvation-inducible protein PhoH
KPL74_11590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KPL74_11595	COG4535	Mg2 and Co2 transporter CorC
KPL74_11615	COG2376	Dihydroxyacetone kinase
KPL74_11630	COG2755	lipolytic protein G-D-S-L family
KPL74_11630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KPL74_11640	COG0823	Involved in the tonB-independent uptake of proteins
KPL74_11640	COG1506	peptidase
KPL74_11690	COG0438	transferase activity, transferring glycosyl groups
KPL74_11690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KPL74_11705	COG2226	methyltransferase
KPL74_11730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KPL74_11740	COG3706	GGDEF domain
KPL74_11740	COG5001	Diguanylate cyclase
KPL74_11740	COG2203	Gaf domain
KPL74_11740	COG4251	negative regulation of phosphorylation
KPL74_11750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KPL74_11785	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KPL74_11790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KPL74_11800	COG2197	response regulator
KPL74_11805	COG0432	Pfam Uncharacterised protein family UPF0047
KPL74_11810	COG0259	pyridoxamine-phosphate oxidase activity
KPL74_11815	COG0572	uridine kinase
KPL74_11825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KPL74_11840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KPL74_11850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KPL74_11865	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KPL74_11885	COG2363	Small membrane protein
KPL74_11890	COG1999	signal sequence binding
KPL74_11900	COG1254	Belongs to the acylphosphatase family
KPL74_11905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KPL74_11910	COG1295	ribonuclease BN
KPL74_11925	COG1960	acyl-CoA dehydrogenase activity
KPL74_11935	COG1404	Belongs to the peptidase S8 family
KPL74_11940	COG3227	Zinc metalloprotease (Elastase)
KPL74_11950	COG2151	metal-sulfur cluster biosynthetic enzyme
KPL74_11980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KPL74_11980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KPL74_12000	COG0825	malonyl-CoA metabolic process
KPL74_12015	COG1722	exodeoxyribonuclease VII activity
KPL74_12020	COG0142	geranyltranstransferase activity
KPL74_12035	COG0312	modulator of DNA gyrase
KPL74_12045	COG3028	Belongs to the UPF0307 family
KPL74_12050	COG0312	modulator of DNA gyrase
KPL74_12085	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KPL74_12100	COG0495	leucyl-tRNA aminoacylation
KPL74_12110	COG3008	intermembrane lipid transfer
KPL74_12115	COG2995	paraquat-inducible protein a
KPL74_12120	COG2995	paraquat-inducible protein a
KPL74_12125	COG3118	belongs to the thioredoxin family
KPL74_12145	COG0783	Belongs to the Dps family
KPL74_12150	COG0642	Histidine kinase
KPL74_12170	COG2132	Multicopper oxidase
KPL74_12175	COG3511	phospholipase C
KPL74_12180	COG3590	peptidase
KPL74_12185	COG4774	siderophore transport
KPL74_12190	COG3128	pkhd-type hydroxylase
KPL74_12225	COG0861	Integral membrane protein TerC family
KPL74_12260	COG0446	pyridine nucleotide-disulphide oxidoreductase
KPL74_12260	COG1902	pentaerythritol trinitrate reductase activity
KPL74_12275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KPL74_12295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KPL74_12310	COG0673	inositol 2-dehydrogenase activity
KPL74_12320	COG0494	nUDIX hydrolase
KPL74_12335	COG1024	Enoyl-CoA hydratase
KPL74_12345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KPL74_12350	COG0860	N-Acetylmuramoyl-L-alanine amidase
KPL74_12355	COG0802	atpase or kinase
KPL74_12360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KPL74_12360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KPL74_12365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KPL74_12385	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
KPL74_12390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KPL74_12405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KPL74_12415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KPL74_12420	COG0201	protein transport
KPL74_12430	COG1841	ribosomal large subunit assembly
KPL74_12435	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KPL74_12450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KPL74_12455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KPL74_12460	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KPL74_12465	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KPL74_12480	COG0255	Belongs to the universal ribosomal protein uL29 family
KPL74_12485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KPL74_12490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KPL74_12495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KPL74_12500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KPL74_12505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KPL74_12515	COG0088	Forms part of the polypeptide exit tunnel
KPL74_12520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KPL74_12525	COG0051	transcription antitermination factor activity, RNA binding
KPL74_12545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KPL74_12550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KPL74_12560	COG0222	ribosome binding
KPL74_12565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KPL74_12570	COG0081	regulation of translation
KPL74_12575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KPL74_12580	COG0250	Participates in transcription elongation, termination and antitermination
KPL74_12585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KPL74_12615	COG1607	acyl-coa hydrolase
KPL74_12620	COG2208	phosphoserine phosphatase activity
KPL74_12620	COG2770	Histidine kinase
KPL74_12630	COG1366	Belongs to the anti-sigma-factor antagonist family
KPL74_12635	COG1846	Transcriptional regulator
KPL74_12645	COG0012	GTP binding
KPL74_12650	COG0193	aminoacyl-tRNA hydrolase activity
KPL74_12655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KPL74_12660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KPL74_12670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KPL74_12675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KPL74_12685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KPL74_12690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KPL74_12715	COG1131	(ABC) transporter
KPL74_12725	COG2197	response regulator
KPL74_12730	COG4585	Histidine kinase
KPL74_12745	COG2894	cell division
KPL74_12750	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KPL74_12760	COG2814	Major facilitator Superfamily
KPL74_12765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KPL74_12770	COG0477	Major facilitator Superfamily
KPL74_12820	COG3064	Membrane
KPL74_12850	COG0300	oxidoreductase activity
KPL74_12855	COG2207	Transcriptional regulator
KPL74_12860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KPL74_12865	COG3387	PFAM Glycoside hydrolase 15-related
KPL74_12870	COG3940	Belongs to the glycosyl hydrolase 43 family
KPL74_12890	COG2186	Transcriptional regulator
KPL74_12895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KPL74_12895	COG4651	solute:proton antiporter activity
KPL74_12900	COG0514	ATP-dependent DNA helicase (RecQ)
KPL74_12920	COG0306	phosphate transporter
KPL74_12930	COG1253	flavin adenine dinucleotide binding
KPL74_12950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KPL74_12955	COG0628	permease
KPL74_12965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KPL74_12970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KPL74_12980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KPL74_12985	COG0271	Belongs to the BolA IbaG family
KPL74_13010	COG1137	ATPase activity
KPL74_13020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KPL74_13025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KPL74_13035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KPL74_13035	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KPL74_13045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KPL74_13050	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KPL74_13055	COG3657	addiction module killer protein
KPL74_13065	COG1960	acyl-CoA dehydrogenase activity
KPL74_13075	COG1309	transcriptional regulator
KPL74_13080	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KPL74_13110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KPL74_13120	COG0463	Glycosyl transferase, family 2
KPL74_13145	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
KPL74_13150	COG0509	glycine decarboxylation via glycine cleavage system
KPL74_13160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KPL74_13165	COG1127	ABC transporter
KPL74_13170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KPL74_13170	COG3218	ABC-type transport auxiliary lipoprotein component
KPL74_13180	COG0154	amidase activity
KPL74_13195	COG0463	Glycosyl transferase, family 2
KPL74_13195	COG1216	Glycosyl transferase, family 2
KPL74_13215	COG0546	phosphoglycolate phosphatase activity
KPL74_13215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KPL74_13230	COG0300	oxidoreductase activity
KPL74_13240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPL74_13240	COG0493	'glutamate synthase
KPL74_13285	COG0626	cystathionine gamma-synthase activity
KPL74_13325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KPL74_13330	COG0583	DNA-binding transcription factor activity
KPL74_13335	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_13340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KPL74_13380	COG0126	phosphoglycerate kinase activity
KPL74_13390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KPL74_13390	COG2755	lipolytic protein G-D-S-L family
KPL74_13400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KPL74_13420	COG3588	fructose-bisphosphate aldolase
KPL74_13430	COG0469	pyruvate kinase activity
KPL74_13445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KPL74_13465	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KPL74_13495	COG0022	dehydrogenase e1 component
KPL74_13505	COG4807	Protein conserved in bacteria
KPL74_13520	COG0010	Belongs to the arginase family
KPL74_13560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KPL74_13595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KPL74_13605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KPL74_13685	COG1082	Xylose isomerase domain protein TIM barrel
KPL74_13690	COG3850	Histidine kinase
KPL74_13700	COG0784	Response regulator, receiver
KPL74_13700	COG2198	Histidine kinase
KPL74_13700	COG2205	protein histidine kinase activity
KPL74_13740	COG1272	protein, Hemolysin III
KPL74_13775	COG2814	Major facilitator Superfamily
KPL74_13785	COG1073	alpha beta
KPL74_13800	COG0673	inositol 2-dehydrogenase activity
KPL74_13805	COG0673	inositol 2-dehydrogenase activity
KPL74_13820	COG1172	Belongs to the binding-protein-dependent transport system permease family
KPL74_13830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KPL74_13835	COG3962	Belongs to the TPP enzyme family
KPL74_13845	COG3718	enzyme involved in inositol metabolism
KPL74_13870	COG1295	ribonuclease BN
KPL74_13875	COG3134	Outer membrane lipoprotein
KPL74_13880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KPL74_13885	COG1506	peptidase
KPL74_13885	COG0823	Involved in the tonB-independent uptake of proteins
KPL74_13915	COG4566	intracellular signal transduction
KPL74_13930	COG0655	NAD(P)H dehydrogenase (quinone) activity
KPL74_13950	COG0366	Alpha amylase catalytic
KPL74_13970	COG1280	lysine exporter protein (LysE YggA)
KPL74_13975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KPL74_14005	COG0784	Response regulator, receiver
KPL74_14005	COG2198	Histidine kinase
KPL74_14005	COG2205	protein histidine kinase activity
KPL74_14015	COG2172	sigma factor antagonist activity
KPL74_14020	COG1366	Belongs to the anti-sigma-factor antagonist family
KPL74_14025	COG1366	Belongs to the anti-sigma-factor antagonist family
KPL74_14030	COG0784	Response regulator, receiver
KPL74_14030	COG2205	protein histidine kinase activity
KPL74_14050	COG0667	Aldo Keto reductase
KPL74_14060	COG1113	amino acid transport
KPL74_14085	COG0513	Belongs to the DEAD box helicase family
KPL74_14090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPL74_14120	COG1132	(ABC) transporter
KPL74_14175	COG0402	S-adenosylhomocysteine deaminase activity
KPL74_14180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KPL74_14200	COG2244	polysaccharide biosynthetic process
KPL74_14230	COG3038	cytochrome b561
KPL74_14250	COG1595	DNA-templated transcription, initiation
KPL74_14260	COG1404	Belongs to the peptidase S8 family
KPL74_14270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KPL74_14275	COG2837	iron assimilation
KPL74_14280	COG1301	dicarboxylic acid transport
KPL74_14290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KPL74_14295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KPL74_14300	COG2828	Protein conserved in bacteria
KPL74_14305	COG0583	DNA-binding transcription factor activity
KPL74_14320	COG0243	molybdopterin cofactor binding
KPL74_14335	COG0746	molybdenum cofactor guanylyltransferase activity
KPL74_14340	COG0303	'Molybdopterin
KPL74_14345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KPL74_14350	COG0667	Aldo Keto reductase
KPL74_14360	COG0300	oxidoreductase activity
KPL74_14365	COG1819	glycosyl
KPL74_14375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KPL74_14395	COG4214	carbohydrate transport
KPL74_14400	COG1129	ABC transporter
KPL74_14405	COG4213	ABC transporter substrate-binding protein
KPL74_14410	COG1070	Carbohydrate kinase
KPL74_14415	COG2115	Belongs to the xylose isomerase family
KPL74_14420	COG2207	Transcriptional regulator
KPL74_14420	COG1609	Transcriptional regulator
KPL74_14430	COG0488	(ABC) transporter
KPL74_14435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KPL74_14440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KPL74_14455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KPL74_14465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KPL74_14505	COG0189	ligase activity
KPL74_14505	COG4067	protein conserved in archaea
KPL74_14540	COG5001	Diguanylate cyclase
KPL74_14540	COG5002	protein histidine kinase activity
KPL74_14540	COG3447	MASE1 domain protein
KPL74_14555	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KPL74_14570	COG4773	Receptor
KPL74_14590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KPL74_14610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPL74_14705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KPL74_14710	COG0028	Belongs to the TPP enzyme family
KPL74_14715	COG0471	metal ion transport
KPL74_14715	COG0490	domain, Protein
KPL74_14730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KPL74_14730	COG2169	Transcriptional regulator
KPL74_14735	COG0697	spore germination
KPL74_14740	COG0577	efflux transmembrane transporter activity
KPL74_14745	COG0577	efflux transmembrane transporter activity
KPL74_14745	COG1136	(ABC) transporter
KPL74_14750	COG1136	(ABC) transporter
KPL74_14755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPL74_14760	COG0179	Fumarylacetoacetate (FAA) hydrolase
KPL74_14765	COG1970	mechanosensitive ion channel activity
KPL74_14790	COG2205	protein histidine kinase activity
KPL74_14795	COG2234	aminopeptidase activity
KPL74_14810	COG1846	Transcriptional regulator
KPL74_14815	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KPL74_14845	COG0714	Associated with various cellular activities
KPL74_14900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KPL74_14905	COG1368	sulfuric ester hydrolase activity
KPL74_14915	COG0459	protein refolding
KPL74_14940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KPL74_14945	COG0511	ligase activity, forming carbon-carbon bonds
KPL74_14950	COG0439	Biotin carboxylase
KPL74_14955	COG2264	protein methyltransferase activity
KPL74_14970	COG0138	bifunctional purine biosynthesis protein purh
KPL74_14980	COG0583	DNA-binding transcription factor activity
KPL74_15015	COG0837	glucose binding
KPL74_15020	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KPL74_15035	COG0531	amino acid
KPL74_15040	COG3250	beta-galactosidase activity
KPL74_15060	COG0210	DNA helicase
KPL74_15065	COG0443	Heat shock 70 kDa protein
KPL74_15120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KPL74_15130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KPL74_15145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPL74_15190	COG3220	belongs to the UPF0276 family
KPL74_15200	COG1595	DNA-templated transcription, initiation
KPL74_15205	COG4944	Protein of unknown function (DUF1109)
KPL74_15255	COG2197	response regulator
KPL74_15260	COG3710	Transcriptional regulator
KPL74_15315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KPL74_15320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KPL74_15330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KPL74_15335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KPL74_15350	COG0134	indole-3-glycerol-phosphate synthase activity
KPL74_15355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KPL74_15360	COG0512	Glutamine amidotransferase of anthranilate synthase
KPL74_15370	COG1335	isochorismatase
KPL74_15375	COG0477	Major facilitator Superfamily
KPL74_15385	COG0596	Alpha beta hydrolase
KPL74_15415	COG0346	lactoylglutathione lyase activity
KPL74_15420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KPL74_15430	COG2197	response regulator
KPL74_15455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KPL74_15515	COG0280	phosphate acetyltransferase
KPL74_15515	COG0281	malic enzyme
KPL74_15535	COG1131	(ABC) transporter
KPL74_15540	COG0842	Transport permease protein
KPL74_15545	COG1187	pseudouridine synthase activity
KPL74_15570	COG1643	Atp-dependent helicase
KPL74_15575	COG1450	Type ii and iii secretion system protein
KPL74_15590	COG3166	PFAM Fimbrial assembly family protein
KPL74_15595	COG3156	type II secretion system protein K
KPL74_15605	COG2165	general secretion pathway protein
KPL74_15615	COG2165	general secretion pathway protein
KPL74_15620	COG1459	type II secretion system
KPL74_15625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KPL74_15645	COG1404	Belongs to the peptidase S8 family
KPL74_15650	COG0084	hydrolase, TatD family'
KPL74_15655	COG0025	NhaP-type Na H and K H
KPL74_15685	COG1191	sigma factor activity
KPL74_15700	COG1307	EDD domain protein, DegV family
KPL74_15715	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_15720	COG1119	ATPase activity
KPL74_15730	COG0616	signal peptide processing
KPL74_15735	COG0534	Mate efflux family protein
KPL74_15745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KPL74_15755	COG1012	belongs to the aldehyde dehydrogenase family
KPL74_15775	COG2205	protein histidine kinase activity
KPL74_15800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KPL74_15805	COG0745	RESPONSE REGULATOR receiver
KPL74_15810	COG2177	Part of the ABC transporter FtsEX involved in
KPL74_15815	COG2884	Cell division ATP-binding protein ftsE
KPL74_15830	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KPL74_15845	COG2067	long-chain fatty acid transport protein
KPL74_15850	COG3100	YcgL domain-containing protein
KPL74_15870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KPL74_15875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KPL74_15880	COG4558	Periplasmic binding protein
KPL74_15885	COG3720	iron ion transport
KPL74_15900	COG0837	glucose binding
KPL74_15905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KPL74_15910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KPL74_15915	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KPL74_15920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KPL74_15925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KPL74_15940	COG1131	(ABC) transporter
KPL74_15960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KPL74_15970	COG1435	thymidine kinase activity
KPL74_15975	COG0210	DNA helicase
KPL74_15990	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KPL74_16000	COG2937	Belongs to the GPAT DAPAT family
KPL74_16005	COG2226	methyltransferase
KPL74_16020	COG0308	aminopeptidase N
KPL74_16050	COG0037	tRNA processing
KPL74_16065	COG1566	PFAM secretion protein HlyD family protein
KPL74_16075	COG1289	transmembrane transporter activity
KPL74_16090	COG0583	DNA-binding transcription factor activity
KPL74_16100	COG0612	Peptidase, M16
KPL74_16110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KPL74_16125	COG0564	pseudouridine synthase activity
KPL74_16145	COG0583	DNA-binding transcription factor activity
KPL74_16150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KPL74_16155	COG2224	Isocitrate lyase
KPL74_16160	COG3263	regulation of cellular component size
KPL74_16170	COG0596	Alpha beta hydrolase
KPL74_16180	COG1902	pentaerythritol trinitrate reductase activity
KPL74_16185	COG0529	Catalyzes the synthesis of activated sulfate
KPL74_16185	COG2046	Belongs to the sulfate adenylyltransferase family
KPL74_16190	COG0606	chelatase, subunit chli
KPL74_16210	COG0588	phosphoglycerate mutase activity
KPL74_16220	COG0408	coproporphyrinogen oxidase activity
KPL74_16230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KPL74_16240	COG0463	Glycosyl transferase, family 2
KPL74_16260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KPL74_16285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KPL74_16290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KPL74_16295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KPL74_16300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KPL74_16335	COG0720	synthase
KPL74_16340	COG4566	intracellular signal transduction
KPL74_16375	COG0316	Belongs to the HesB IscA family
KPL74_16380	COG2816	NAD+ diphosphatase activity
KPL74_16395	COG0151	Belongs to the GarS family
KPL74_16400	COG0318	PFAM AMP-dependent synthetase and ligase
KPL74_16405	COG0009	L-threonylcarbamoyladenylate synthase
KPL74_16415	COG0758	DNA mediated transformation
KPL74_16420	COG1652	LysM domain
KPL74_16430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KPL74_16435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KPL74_16470	COG1490	D-aminoacyl-tRNA deacylase activity
KPL74_16475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KPL74_16490	COG2885	chlorophyll binding
KPL74_16520	COG2132	Multicopper oxidase
KPL74_16550	COG0673	inositol 2-dehydrogenase activity
KPL74_16555	COG3530	Putative quorum-sensing-regulated virulence factor
KPL74_16560	COG1609	Transcriptional regulator
KPL74_16570	COG2211	Major facilitator Superfamily
KPL74_16595	COG3622	Belongs to the hyi family
KPL74_16620	COG3128	pkhd-type hydroxylase
KPL74_16650	COG1538	Outer membrane efflux protein
KPL74_16675	COG4139	cobalamin transport
KPL74_16680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KPL74_16685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KPL74_16690	COG0784	Response regulator, receiver
KPL74_16690	COG4191	Histidine kinase
KPL74_16700	COG1368	sulfuric ester hydrolase activity
KPL74_16710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KPL74_16715	COG0840	transmembrane signaling receptor activity
KPL74_16720	COG1595	DNA-templated transcription, initiation
KPL74_16730	COG4774	siderophore transport
KPL74_16740	COG3346	SURF1 family
KPL74_16745	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KPL74_16750	COG1845	cytochrome c oxidase, subunit III
KPL74_16755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KPL74_16760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KPL74_16765	COG0477	Major facilitator Superfamily
KPL74_16785	COG3548	integral membrane protein
KPL74_16790	COG2814	Major facilitator Superfamily
KPL74_16810	COG0840	transmembrane signaling receptor activity
KPL74_16815	COG4953	penicillin-binding protein 1C
KPL74_16820	COG2373	Large extracellular alpha-helical protein
KPL74_16825	COG3920	Histidine kinase
KPL74_16840	COG3795	YCII-related domain
KPL74_16845	COG4941	Belongs to the sigma-70 factor family
KPL74_16860	COG0392	lysyltransferase activity
KPL74_16865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KPL74_16870	COG4149	molybdate abc transporter
KPL74_16875	COG0725	ABC transporter, periplasmic molybdate-binding protein
KPL74_16910	COG4191	Histidine kinase
KPL74_16925	COG0577	efflux transmembrane transporter activity
KPL74_16925	COG1136	(ABC) transporter
KPL74_16930	COG0784	Response regulator, receiver
KPL74_16930	COG4191	Histidine kinase
KPL74_16940	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_16955	COG0596	Alpha beta hydrolase
KPL74_16960	COG3250	beta-galactosidase activity
KPL74_16965	COG0174	glutamine synthetase
KPL74_17000	COG2814	Major facilitator Superfamily
KPL74_17005	COG1566	PFAM secretion protein HlyD family protein
KPL74_17015	COG1968	undecaprenyl-diphosphatase activity
KPL74_17020	COG0583	DNA-binding transcription factor activity
KPL74_17045	COG0628	permease
KPL74_17070	COG1881	PFAM PEBP family protein
KPL74_17075	COG0429	hydrolase of the alpha beta-hydrolase fold
KPL74_17085	COG1522	sequence-specific DNA binding
KPL74_17090	COG3186	Phenylalanine-4-hydroxylase
KPL74_17105	COG5654	RES domain protein
KPL74_17120	COG2378	regulation of single-species biofilm formation
KPL74_17140	COG1752	Esterase of the alpha-beta hydrolase superfamily
KPL74_17190	COG0463	Glycosyl transferase, family 2
KPL74_17200	COG0277	FAD linked oxidase domain protein
KPL74_17225	COG0596	Alpha beta hydrolase
KPL74_17230	COG0300	oxidoreductase activity
KPL74_17240	COG0417	DNA replication proofreading
KPL74_17270	COG3663	DNA glycosylase
KPL74_17280	COG5002	protein histidine kinase activity
KPL74_17280	COG3447	MASE1 domain protein
KPL74_17280	COG5001	Diguanylate cyclase
KPL74_17285	COG0251	oxidation-reduction process
KPL74_17295	COG5212	phosphodiesterase
KPL74_17310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KPL74_17320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KPL74_17325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KPL74_17330	COG1538	Outer membrane efflux protein
KPL74_17385	COG0561	phosphatase activity
KPL74_17390	COG0583	DNA-binding transcription factor activity
KPL74_17395	COG0604	alcohol dehydrogenase
KPL74_17455	COG0477	Major facilitator Superfamily
KPL74_17475	COG2205	protein histidine kinase activity
KPL74_17475	COG0784	Response regulator, receiver
KPL74_17475	COG2198	Histidine kinase
KPL74_17485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KPL74_17515	COG0187	DNA topoisomerase II activity
KPL74_17520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KPL74_17525	COG0592	DNA-directed DNA polymerase activity
KPL74_17530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KPL74_17535	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KPL74_17540	COG0594	ribonuclease P activity
KPL74_17545	COG0706	membrane insertase activity
KPL74_17550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KPL74_17555	COG1487	ribonuclease activity
KPL74_17570	COG2814	Major facilitator Superfamily
KPL74_17575	COG0583	DNA-binding transcription factor activity
KPL74_17580	COG1064	alcohol dehydrogenase
KPL74_17595	COG4650	regulator
KPL74_17600	COG1690	Belongs to the RtcB family
KPL74_17605	COG0430	RNA-3'-phosphate cyclase activity
KPL74_17615	COG0300	oxidoreductase activity
KPL74_17620	COG1674	ftsk spoiiie
KPL74_17625	COG1879	ABC-type sugar transport system periplasmic component
KPL74_17630	COG1172	Belongs to the binding-protein-dependent transport system permease family
KPL74_17635	COG1129	ABC transporter
KPL74_17640	COG1869	D-ribose catabolic process
KPL74_17645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KPL74_17665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KPL74_17680	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KPL74_17690	COG0456	acetyltransferase
KPL74_17695	COG0189	ligase activity
KPL74_17710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KPL74_17735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KPL74_17745	COG0708	Exodeoxyribonuclease III
KPL74_17765	COG1741	Belongs to the pirin family
KPL74_17780	COG0395	ABC-type sugar transport system, permease component
KPL74_17860	COG0357	Ribosomal RNA small subunit methyltransferase G
KPL74_17870	COG1192	Involved in chromosome partitioning
KPL74_17875	COG1475	DNA binding
KPL74_17890	COG0463	Glycosyl transferase, family 2
KPL74_17915	COG0181	hydroxymethylbilane synthase activity
KPL74_17925	COG3275	phosphorelay sensor kinase activity
KPL74_17935	COG0038	chloride channel
KPL74_17940	COG0754	glutathionylspermidine amidase activity
KPL74_17955	COG1505	serine-type exopeptidase activity
KPL74_17970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KPL74_17975	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KPL74_17990	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KPL74_17995	COG2205	protein histidine kinase activity
KPL74_18000	COG0745	RESPONSE REGULATOR receiver
KPL74_18010	COG2207	Transcriptional regulator
KPL74_18020	COG1846	Transcriptional regulator
KPL74_18030	COG1566	PFAM secretion protein HlyD family protein
KPL74_18035	COG2814	Major facilitator Superfamily
KPL74_18050	COG3384	dioxygenase
KPL74_18065	COG4206	TonB-dependent receptor
KPL74_18075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KPL74_18080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KPL74_18085	COG2188	Transcriptional regulator
KPL74_18090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KPL74_18095	COG0363	glucosamine-6-phosphate deaminase activity
KPL74_18100	COG0129	dihydroxy-acid dehydratase activity
KPL74_18105	COG0800	Aldolase
KPL74_18110	COG0697	spore germination
KPL74_18115	COG0477	Major facilitator Superfamily
KPL74_18120	COG1609	Transcriptional regulator
KPL74_18130	COG0837	glucose binding
KPL74_18140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
KPL74_18145	COG1201	RNA secondary structure unwinding
KPL74_18150	COG1472	Belongs to the glycosyl hydrolase 3 family
KPL74_18180	COG0392	lysyltransferase activity
KPL74_18180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KPL74_18185	COG1368	sulfuric ester hydrolase activity
KPL74_18190	COG1741	Belongs to the pirin family
KPL74_18200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPL74_18220	COG2197	response regulator
KPL74_18225	COG4977	sequence-specific DNA binding
KPL74_18235	COG4772	TonB-dependent receptor
KPL74_18250	COG0204	Acyl-transferase
KPL74_18260	COG2132	Multicopper oxidase
KPL74_18295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KPL74_18340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPL74_18355	COG0583	DNA-binding transcription factor activity
KPL74_18360	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_18365	COG0784	Response regulator, receiver
KPL74_18365	COG4191	Histidine kinase
KPL74_18370	COG3360	Dodecin
KPL74_18400	COG0702	epimerase
KPL74_18445	COG1794	racemase activity, acting on amino acids and derivatives
KPL74_18455	COG0784	Response regulator, receiver
KPL74_18460	COG4251	negative regulation of phosphorylation
KPL74_18465	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
KPL74_18470	COG5295	Hep Hag repeat protein
KPL74_18475	COG2814	Major facilitator Superfamily
KPL74_18535	COG0183	Belongs to the thiolase family
KPL74_18545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KPL74_18550	COG2353	YceI-like domain
KPL74_18580	COG1166	arginine decarboxylase activity
KPL74_18585	COG2084	Dehydrogenase
KPL74_18600	COG2003	Belongs to the UPF0758 family
KPL74_18605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KPL74_18610	COG0756	dUTP diphosphatase activity
KPL74_18625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KPL74_18630	COG0708	Exodeoxyribonuclease III
KPL74_18635	COG2211	Major facilitator Superfamily
KPL74_18650	COG0739	heme binding
KPL74_18655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KPL74_18700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KPL74_18755	COG2183	response to ionizing radiation
KPL74_18760	COG1714	RDD family
KPL74_18770	COG0308	aminopeptidase N
KPL74_18780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KPL74_18785	COG0519	Catalyzes the synthesis of GMP from XMP
KPL74_18795	COG2267	carboxylic ester hydrolase activity
KPL74_18800	COG1054	Belongs to the UPF0176 family
KPL74_18805	COG0156	8-amino-7-oxononanoate synthase activity
KPL74_18810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KPL74_18820	COG1040	competence protein
KPL74_18835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KPL74_18850	COG0246	Mannitol dehydrogenase
KPL74_18860	COG0395	ABC-type sugar transport system, permease component
KPL74_18865	COG1175	transmembrane transport
KPL74_18870	COG1653	transport
KPL74_18895	COG0028	Belongs to the TPP enzyme family
KPL74_18900	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KPL74_18905	COG0129	dihydroxy-acid dehydratase activity
KPL74_18910	COG0473	3-isopropylmalate dehydrogenase activity
KPL74_18915	COG0066	3-isopropylmalate dehydratase activity
KPL74_18920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KPL74_18925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KPL74_18930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KPL74_18960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KPL74_18970	COG0527	aspartate kinase activity
KPL74_18970	COG0460	homoserine dehydrogenase
KPL74_18975	COG0737	Belongs to the 5'-nucleotidase family
KPL74_18990	COG0584	glycerophosphoryl diester phosphodiesterase
KPL74_18995	COG0531	amino acid
KPL74_19045	COG0625	glutathione transferase activity
KPL74_19075	COG0583	DNA-binding transcription factor activity
KPL74_19080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPL74_19095	COG1902	pentaerythritol trinitrate reductase activity
KPL74_19100	COG0625	glutathione transferase activity
KPL74_19105	COG0625	glutathione transferase activity
KPL74_19125	COG0745	RESPONSE REGULATOR receiver
KPL74_19155	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KPL74_19155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KPL74_19160	COG0667	Aldo Keto reductase
KPL74_19165	COG0789	Transcriptional regulator
KPL74_19190	COG1012	belongs to the aldehyde dehydrogenase family
KPL74_19195	COG3284	Transcriptional regulator
KPL74_19200	COG1607	acyl-coa hydrolase
KPL74_19205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KPL74_19215	COG0784	Response regulator, receiver
KPL74_19215	COG4191	Histidine kinase
KPL74_19225	COG3250	beta-galactosidase activity
KPL74_19230	COG0840	transmembrane signaling receptor activity
KPL74_19235	COG0318	PFAM AMP-dependent synthetase and ligase
KPL74_19245	COG2223	nitrite transmembrane transporter activity
KPL74_19255	COG3265	gluconokinase activity
KPL74_19265	COG3023	N-Acetylmuramoyl-L-alanine amidase
KPL74_19275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KPL74_19295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPL74_19315	COG3240	lipase activity
KPL74_19320	COG0667	Aldo Keto reductase
KPL74_19330	COG0583	DNA-binding transcription factor activity
KPL74_19355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPL74_19360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPL74_19375	COG2205	protein histidine kinase activity
KPL74_19380	COG3706	GGDEF domain
KPL74_19385	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KPL74_19385	COG2755	lipolytic protein G-D-S-L family
KPL74_19395	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KPL74_19415	COG1162	GTPase activity
KPL74_19445	COG2267	carboxylic ester hydrolase activity
KPL74_19465	COG4555	ABC transporter
KPL74_19470	COG1668	transmembrane transport
KPL74_19475	COG4772	TonB-dependent receptor
KPL74_19485	COG1187	pseudouridine synthase activity
KPL74_19490	COG4948	Mandelate Racemase Muconate Lactonizing
KPL74_19495	COG0800	Aldolase
KPL74_19500	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_19510	COG1172	Belongs to the binding-protein-dependent transport system permease family
KPL74_19515	COG1129	ABC transporter
KPL74_19530	COG0583	DNA-binding transcription factor activity
KPL74_19535	COG0586	Pfam SNARE associated Golgi protein
KPL74_19540	COG0358	DNA primase activity
KPL74_19550	COG1610	YqeY-like protein
KPL74_19560	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KPL74_19565	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KPL74_19570	COG0668	transmembrane transport
KPL74_19585	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_19605	COG0617	tRNA 3'-terminal CCA addition
KPL74_19610	COG0702	epimerase
KPL74_19635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPL74_19650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KPL74_19655	COG1956	GAF domain-containing protein
KPL74_19660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KPL74_19670	COG0339	signal peptide processing
KPL74_19700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KPL74_19705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KPL74_19715	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
KPL74_19740	COG1612	heme a metabolic process
KPL74_19745	COG0109	protoheme IX farnesyltransferase activity
KPL74_19750	COG0596	Alpha beta hydrolase
KPL74_19750	COG0508	dehydrogenase complex catalyzes the overall conversion of
KPL74_19755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KPL74_19765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KPL74_19775	COG0805	protein transport
KPL74_19785	COG0793	Belongs to the peptidase S41A family
KPL74_19790	COG4942	peptidase
KPL74_19795	COG0070	glutamate synthase
KPL74_19795	COG0067	glutamate synthase
KPL74_19795	COG0069	glutamate synthase activity
KPL74_19800	COG0493	'glutamate synthase
KPL74_19810	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_19845	COG1199	ATP-dependent helicase activity
KPL74_19870	COG1131	(ABC) transporter
KPL74_19875	COG0842	Transport permease protein
KPL74_19940	COG1196	nuclear chromosome segregation
KPL74_19955	COG0302	gtp cyclohydrolase
KPL74_19960	COG1322	Protein conserved in bacteria
KPL74_19965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KPL74_19975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KPL74_20000	COG0006	proline dipeptidase activity
KPL74_20005	COG0006	proline dipeptidase activity
KPL74_20025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KPL74_20040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KPL74_20045	COG1561	YicC-like family, N-terminal region
KPL74_20125	COG1127	ABC transporter
KPL74_20130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KPL74_20150	COG2853	Lipoprotein
KPL74_20155	COG1758	RNA polymerase activity
KPL74_20160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KPL74_20170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KPL74_20215	COG1560	Kdo2-lipid A biosynthetic process
KPL74_20220	COG1519	Transferase
KPL74_20230	COG1538	Outer membrane efflux protein
KPL74_20235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KPL74_20255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KPL74_20260	COG1505	serine-type exopeptidase activity
KPL74_20265	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
KPL74_20280	COG0402	S-adenosylhomocysteine deaminase activity
KPL74_20295	COG1573	uracil-dna glycosylase
KPL74_20315	COG0563	adenylate kinase activity
KPL74_20320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KPL74_20335	COG2204	response regulator
KPL74_20340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KPL74_20345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KPL74_20350	COG0352	thiamine-phosphate diphosphorylase activity
KPL74_20355	COG1773	rubredoxin
KPL74_20395	COG1349	DNA-binding transcription factor activity
KPL74_20405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KPL74_20410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KPL74_20415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KPL74_20420	COG1077	Cell shape determining protein MreB Mrl
KPL74_20425	COG1792	Involved in formation and maintenance of cell shape
KPL74_20435	COG0768	penicillin binding
KPL74_20440	COG0772	Belongs to the SEDS family
KPL74_20445	COG2951	lytic endotransglycosylase activity
KPL74_20450	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KPL74_20455	COG1686	Belongs to the peptidase S11 family
KPL74_20470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KPL74_20480	COG0668	transmembrane transport
KPL74_20485	COG0508	dehydrogenase complex catalyzes the overall conversion of
KPL74_20490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KPL74_20500	COG0531	amino acid
KPL74_20525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KPL74_20535	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KPL74_20540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KPL74_20555	COG0745	RESPONSE REGULATOR receiver
KPL74_20560	COG2205	protein histidine kinase activity
KPL74_20590	COG3161	chorismate lyase activity
KPL74_20610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KPL74_20615	COG1011	Hydrolase
KPL74_20620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KPL74_20625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPL74_20655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KPL74_20770	COG2764	glyoxalase bleomycin resistance protein dioxygenase
KPL74_20775	COG2378	regulation of single-species biofilm formation
KPL74_20830	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_20845	COG3268	Saccharopine dehydrogenase
KPL74_20850	COG1028	Short-chain dehydrogenase reductase Sdr
KPL74_20855	COG2207	Transcriptional regulator
KPL74_20890	COG0640	Transcriptional regulator
KPL74_20910	COG0784	Response regulator, receiver
KPL74_20910	COG4191	Histidine kinase
KPL74_20915	COG2223	nitrite transmembrane transporter activity
KPL74_20925	COG0667	Aldo Keto reductase
KPL74_20985	COG1732	Glycine betaine
KPL74_20990	COG1174	glycine betaine transport
KPL74_20995	COG1125	glycine betaine transport
KPL74_21000	COG1174	glycine betaine transport
KPL74_21005	COG3590	peptidase
KPL74_21025	COG0792	nuclease activity
KPL74_21035	COG0577	efflux transmembrane transporter activity
KPL74_21055	COG2001	Belongs to the MraZ family
KPL74_21060	COG0275	rRNA processing
KPL74_21065	COG3116	cell division
KPL74_21080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KPL74_21085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KPL74_21095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KPL74_21105	COG1181	Belongs to the D-alanine--D-alanine ligase family
KPL74_21110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KPL74_21125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KPL74_21135	COG0739	heme binding
KPL74_21140	COG0653	protein targeting
KPL74_21155	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KPL74_21160	COG2967	ApaG domain
KPL74_21165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KPL74_21170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KPL74_21175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KPL74_21180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KPL74_21185	COG2096	Adenosyltransferase
KPL74_21190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPL74_21195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPL74_21205	COG0142	geranyltranstransferase activity
KPL74_21210	COG2814	Major facilitator Superfamily
KPL74_21215	COG0629	single-stranded DNA binding
KPL74_21225	COG0596	Alpha beta hydrolase
KPL74_21240	COG0583	DNA-binding transcription factor activity
KPL74_21245	COG0667	Aldo Keto reductase
KPL74_21280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KPL74_21295	COG3537	Alpha-1,2-mannosidase
KPL74_21305	COG0745	RESPONSE REGULATOR receiver
KPL74_21335	COG0045	succinate-CoA ligase (ADP-forming) activity
KPL74_21340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KPL74_21355	COG4948	Mandelate Racemase Muconate Lactonizing
KPL74_21370	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
KPL74_21375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KPL74_21375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPL74_21390	COG0564	pseudouridine synthase activity
KPL74_21395	COG1496	oxidoreductase activity
KPL74_21400	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KPL74_21410	COG0542	response to heat
KPL74_21430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KPL74_21455	COG0217	transcriptional regulatory protein
KPL74_21465	COG0632	four-way junction helicase activity
KPL74_21475	COG2255	four-way junction helicase activity
KPL74_21480	COG0824	Thioesterase
KPL74_21515	COG0602	queuosine metabolic process
KPL74_21520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KPL74_21550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
KPL74_21555	COG2197	response regulator
KPL74_21560	COG5002	protein histidine kinase activity
KPL74_21575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KPL74_21580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KPL74_21590	COG0583	DNA-binding transcription factor activity
KPL74_21595	COG0450	alkyl hydroperoxide reductase
KPL74_21600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KPL74_21605	COG5507	3-demethylubiquinone-9 3-methyltransferase
KPL74_21645	COG1609	Transcriptional regulator
KPL74_21650	COG0673	inositol 2-dehydrogenase activity
KPL74_21675	COG2890	protein-(glutamine-N5) methyltransferase activity
KPL74_21715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KPL74_21735	COG1960	acyl-CoA dehydrogenase activity
KPL74_21750	COG0693	protein deglycase activity
KPL74_21755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KPL74_21780	COG4974	Belongs to the 'phage' integrase family
KPL74_21785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPL74_21790	COG0047	phosphoribosylformylglycinamidine synthase activity
KPL74_21790	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KPL74_21810	COG2186	Transcriptional regulator
KPL74_21820	COG1966	Carbon starvation protein
KPL74_21825	COG0242	peptide deformylase activity
KPL74_21835	COG0284	orotidine-5'-phosphate decarboxylase activity
KPL74_21840	COG0488	(ABC) transporter
KPL74_21860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KPL74_21870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KPL74_21870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KPL74_21875	COG0673	inositol 2-dehydrogenase activity
KPL74_21890	COG1619	proteins homologs of microcin C7 resistance protein MccF
KPL74_21895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KPL74_21900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KPL74_21910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KPL74_21915	COG0667	Aldo Keto reductase
KPL74_21925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KPL74_21945	COG0483	inositol monophosphate 1-phosphatase activity
KPL74_21950	COG0494	nUDIX hydrolase
KPL74_21960	COG3956	TIGRFAM MazG family protein
KPL74_21975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KPL74_21990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KPL74_21990	COG2010	Cytochrome c
KPL74_22000	COG0531	amino acid
KPL74_22005	COG0527	aspartate kinase activity
KPL74_22015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KPL74_22035	COG1862	Preprotein translocase
KPL74_22040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA