locus-tag	class	description
M655_000015	COG0037	tRNA processing
M655_000020	COG3610	response to peptide
M655_000030	COG0515	serine threonine protein kinase
M655_000035	COG2304	oxidoreductase activity
M655_000040	COG2208	phosphoserine phosphatase activity
M655_000045	COG1098	S1 RNA binding domain
M655_000070	COG4533	DNA binding
M655_000085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M655_000090	COG3956	TIGRFAM MazG family protein
M655_000095	COG2244	polysaccharide biosynthetic process
M655_000100	COG2002	toxin-antitoxin pair type II binding
M655_000105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M655_000110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M655_000120	COG0193	aminoacyl-tRNA hydrolase activity
M655_000125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M655_000130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M655_000135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M655_000140	COG0523	cobalamin synthesis protein
M655_000145	COG2088	sporulation resulting in formation of a cellular spore
M655_000150	COG0251	oxidation-reduction process
M655_000155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M655_000160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M655_000170	COG4466	Protein conserved in bacteria
M655_000175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M655_000185	COG3584	3D domain protein
M655_000185	COG1388	LysM domain
M655_000190	COG0084	hydrolase, TatD family'
M655_000195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M655_000195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M655_000200	COG2002	toxin-antitoxin pair type II binding
M655_000205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M655_000210	COG2827	Endonuclease containing a URI domain
M655_000215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M655_000220	COG4467	Involved in initiation control of chromosome replication
M655_000225	COG1774	PSP1 C-terminal conserved region
M655_000235	COG1728	Protein conserved in bacteria
M655_000240	COG3870	Protein conserved in bacteria
M655_000245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M655_000250	COG1982	Orn Lys Arg decarboxylase major
M655_000260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M655_000290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M655_000295	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M655_000300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M655_000305	COG3852	Histidine kinase
M655_000315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M655_000315	COG2199	diguanylate cyclase activity
M655_000325	COG0586	Pfam SNARE associated Golgi protein
M655_000340	COG2910	NAD(P)H-binding
M655_000350	COG1937	Protein conserved in bacteria
M655_000355	COG2210	Belongs to the sulfur carrier protein TusA family
M655_000360	COG0730	response to heat
M655_000365	COG0425	Belongs to the sulfur carrier protein TusA family
M655_000370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M655_000370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M655_000375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M655_000375	COG0425	Belongs to the sulfur carrier protein TusA family
M655_000395	COG1187	pseudouridine synthase activity
M655_000400	COG0590	tRNA wobble adenosine to inosine editing
M655_000410	COG3711	transcriptional antiterminator
M655_000415	COG2190	(PTS) system
M655_000420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M655_000425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M655_000430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M655_000430	COG2190	(PTS) system
M655_000430	COG1263	PTS System
M655_000445	COG1396	sequence-specific DNA binding
M655_000450	COG1733	regulation of RNA biosynthetic process
M655_000455	COG2259	Doxx family
M655_000480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M655_000485	COG1349	DNA-binding transcription factor activity
M655_000490	COG3842	ATPase activity
M655_000495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M655_000500	COG0395	ABC-type sugar transport system, permease component
M655_000515	COG2224	Isocitrate lyase
M655_000520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M655_000525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M655_000530	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M655_000535	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M655_000550	COG0516	GMP reductase activity
M655_000550	COG0517	IMP dehydrogenase activity
M655_000570	COG0586	Pfam SNARE associated Golgi protein
M655_000575	COG0402	S-adenosylhomocysteine deaminase activity
M655_000590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M655_000595	COG2814	Major facilitator Superfamily
M655_000620	COG0586	Pfam SNARE associated Golgi protein
M655_000625	COG0402	S-adenosylhomocysteine deaminase activity
M655_000755	COG0187	DNA topoisomerase II activity
M655_000765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M655_000770	COG2501	S4 domain
M655_000775	COG0592	DNA-directed DNA polymerase activity
M655_000780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M655_000785	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M655_000795	COG0594	ribonuclease P activity
M655_000800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M655_000805	COG0706	membrane insertase activity
M655_000810	COG1847	R3H domain protein
M655_000815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M655_000820	COG0445	tRNA wobble uridine modification
M655_000825	COG0357	Ribosomal RNA small subunit methyltransferase G
M655_000830	COG1285	pathogenesis
M655_000835	COG1475	DNA binding
M655_000840	COG1192	Involved in chromosome partitioning
M655_000845	COG1475	DNA binding
M655_000850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M655_000855	COG1811	Na channel or pump
M655_000860	COG1597	lipid kinase activity
M655_000875	COG0668	transmembrane transport
M655_000880	COG4481	Protein conserved in bacteria
M655_000895	COG1164	Oligoendopeptidase f
M655_000910	COG0702	epimerase
M655_000915	COG0012	GTP binding
M655_000920	COG0360	Binds together with S18 to 16S ribosomal RNA
M655_000925	COG0629	single-stranded DNA binding
M655_000930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M655_000940	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M655_000945	COG0359	binds to the 23S rRNA
M655_000950	COG0305	Participates in initiation and elongation during chromosome replication
M655_000955	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M655_000970	COG0739	heme binding
M655_000975	COG0745	RESPONSE REGULATOR receiver
M655_000980	COG5002	protein histidine kinase activity
M655_000990	COG4853	Protein conserved in bacteria
M655_000995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M655_001005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M655_001015	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M655_001035	COG1136	(ABC) transporter
M655_001035	COG0577	efflux transmembrane transporter activity
M655_001050	COG4977	sequence-specific DNA binding
M655_001060	COG2819	hydrolase of the alpha beta superfamily
M655_001070	COG0745	RESPONSE REGULATOR receiver
M655_001075	COG2205	protein histidine kinase activity
M655_001080	COG1113	amino acid transport
M655_001100	COG3284	Transcriptional regulator
M655_001105	COG0095	Lipoate-protein ligase
M655_001110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M655_001115	COG0022	dehydrogenase e1 component
M655_001120	COG0508	dehydrogenase complex catalyzes the overall conversion of
M655_001125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M655_001130	COG2205	protein histidine kinase activity
M655_001130	COG2770	Histidine kinase
M655_001135	COG0745	RESPONSE REGULATOR receiver
M655_001140	COG1126	abc transporter atp-binding protein
M655_001145	COG0765	amino acid transport
M655_001150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M655_001155	COG1115	amino acid carrier protein
M655_001160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M655_001165	COG2824	Alkylphosphonate utilization operon protein PhnA
M655_001190	COG2204	response regulator
M655_001195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M655_001200	COG1012	belongs to the aldehyde dehydrogenase family
M655_001215	COG2076	Multidrug Resistance protein
M655_001220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M655_001225	COG0672	)-iron permease
M655_001230	COG2837	iron assimilation
M655_001235	COG2822	iron ion transport
M655_001240	COG2186	Transcriptional regulator
M655_001245	COG1556	Lactate utilization protein
M655_001250	COG1139	Iron-sulfur cluster binding protein
M655_001265	COG0647	UMP catabolic process
M655_001270	COG3842	ATPase activity
M655_001285	COG0395	ABC-type sugar transport system, permease component
M655_001300	COG0583	DNA-binding transcription factor activity
M655_001315	COG0601	transmembrane transport
M655_001340	COG2884	Cell division ATP-binding protein ftsE
M655_001375	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M655_001380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_001385	COG1649	PFAM Uncharacterised BCR, COG1649
M655_001400	COG1280	lysine exporter protein (LysE YggA)
M655_001455	COG2198	Histidine kinase
M655_001455	COG0643	Histidine kinase
M655_001460	COG2201	protein-glutamate methylesterase activity
M655_001465	COG0534	Mate efflux family protein
M655_001475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_001480	COG4605	iron ion homeostasis
M655_001485	COG4604	ABC transporter, ATP-binding protein
M655_001490	COG4607	ABC-type enterochelin transport system periplasmic component
M655_001495	COG1120	ATPase activity
M655_001510	COG2011	ABC-type metal ion transport system permease component
M655_001520	COG1464	Belongs to the NlpA lipoprotein family
M655_001540	COG1176	ABC-type spermidine putrescine transport system, permease component I
M655_001550	COG3842	ATPase activity
M655_001555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M655_001560	COG2079	MmgE PrpD family protein
M655_001565	COG1126	abc transporter atp-binding protein
M655_001570	COG0765	amino acid transport
M655_001575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M655_001580	COG0456	acetyltransferase
M655_001585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M655_001590	COG0534	Mate efflux family protein
M655_001595	COG1285	pathogenesis
M655_001635	COG0514	ATP-dependent DNA helicase (RecQ)
M655_001640	COG0477	Major facilitator Superfamily
M655_001660	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M655_001660	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M655_001675	COG3394	polysaccharide catabolic process
M655_001680	COG1447	Phosphotransferase system cellobiose-specific component IIA
M655_001685	COG1486	melibiose metabolic process
M655_001690	COG0561	phosphatase activity
M655_001695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M655_001700	COG2205	protein histidine kinase activity
M655_001710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M655_001725	COG1012	belongs to the aldehyde dehydrogenase family
M655_001770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M655_001775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M655_001785	COG0785	Cytochrome C biogenesis protein
M655_001790	COG3328	transposase activity
M655_001795	COG0785	Cytochrome C biogenesis protein
M655_001815	COG4990	cell redox homeostasis
M655_001825	COG3328	transposase activity
M655_001840	COG3284	Transcriptional regulator
M655_001845	COG3829	transcription factor binding
M655_001845	COG3290	protein histidine kinase activity
M655_001850	COG0473	3-isopropylmalate dehydrogenase activity
M655_001855	COG1012	belongs to the aldehyde dehydrogenase family
M655_001860	COG1028	Short-chain dehydrogenase reductase Sdr
M655_001865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M655_001870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M655_001880	COG0277	FAD linked oxidase domain protein
M655_001885	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M655_001895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M655_001900	COG0513	Belongs to the DEAD box helicase family
M655_001925	COG3711	transcriptional antiterminator
M655_001930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M655_001935	COG0246	Mannitol dehydrogenase
M655_001945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M655_001950	COG3119	arylsulfatase activity
M655_001980	COG1012	belongs to the aldehyde dehydrogenase family
M655_001980	COG1454	alcohol dehydrogenase
M655_001990	COG4869	propanediol catabolic process
M655_002000	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
M655_002030	COG4303	Ethanolamine ammonia lyase large subunit
M655_002035	COG4302	ethanolamine ammonia-lyase activity
M655_002040	COG0039	L-malate dehydrogenase activity
M655_002050	COG2309	aminopeptidase activity
M655_002065	COG1765	OsmC-like protein
M655_002070	COG4187	Peptidase family M20/M25/M40
M655_002075	COG1414	Transcriptional regulator
M655_002085	COG0833	amino acid
M655_002105	COG1846	Transcriptional regulator
M655_002115	COG0840	transmembrane signaling receptor activity
M655_002140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M655_002155	COG0659	secondary active sulfate transmembrane transporter activity
M655_002170	COG0546	phosphoglycolate phosphatase activity
M655_002175	COG3842	ATPase activity
M655_002180	COG1175	transmembrane transport
M655_002190	COG1653	transport
M655_002195	COG0584	glycerophosphoryl diester phosphodiesterase
M655_002205	COG0405	Gamma-glutamyltransferase
M655_002220	COG0531	amino acid
M655_002245	COG0626	cystathionine gamma-synthase activity
M655_002250	COG2204	response regulator
M655_002255	COG2329	Antibiotic biosynthesis monooxygenase
M655_002265	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M655_002275	COG0543	2 iron, 2 sulfur cluster binding
M655_002275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M655_002285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M655_002290	COG0116	Belongs to the methyltransferase superfamily
M655_002315	COG0564	pseudouridine synthase activity
M655_002320	COG0789	Transcriptional regulator
M655_002330	COG1309	transcriptional regulator
M655_002345	COG1078	dGTPase activity
M655_002350	COG3465	dGTPase activity
M655_002390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M655_002395	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M655_002400	COG0010	Belongs to the arginase family
M655_002420	COG3829	transcription factor binding
M655_002425	COG1509	lysine 2,3-aminomutase activity
M655_002430	COG2181	nitrate reductase activity
M655_002430	COG0247	lactate metabolic process
M655_002435	COG0183	Belongs to the thiolase family
M655_002440	COG1250	3-hydroxyacyl-CoA dehydrogenase
M655_002445	COG1960	acyl-CoA dehydrogenase activity
M655_002450	COG1960	acyl-CoA dehydrogenase activity
M655_002455	COG1309	transcriptional regulator
M655_002460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M655_002460	COG1703	isobutyryl-CoA mutase activity
M655_002460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M655_002465	COG0450	alkyl hydroperoxide reductase
M655_002475	COG3343	RNA polymerase activity
M655_002480	COG0504	CTP synthase activity
M655_002490	COG2204	response regulator
M655_002495	COG0191	fructose-bisphosphate aldolase activity
M655_002500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M655_002505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M655_002510	COG1494	fructose-1,6-bisphosphatase
M655_002515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M655_002520	COG0739	heme binding
M655_002530	COG0254	rRNA binding
M655_002540	COG1435	thymidine kinase activity
M655_002550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M655_002555	COG2890	protein-(glutamine-N5) methyltransferase activity
M655_002570	COG0009	L-threonylcarbamoyladenylate synthase
M655_002575	COG1971	Probably functions as a manganese efflux pump
M655_002585	COG0698	ribose 5-phosphate isomerase
M655_002590	COG4475	Protein of unknown function (DUF436)
M655_002600	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M655_002605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M655_002610	COG1361	Conserved repeat domain
M655_002615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M655_002625	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M655_002630	COG0156	8-amino-7-oxononanoate synthase activity
M655_002635	COG0596	Alpha beta hydrolase
M655_002640	COG4106	trans-aconitate 2-methyltransferase activity
M655_002660	COG0356	it plays a direct role in the translocation of protons across the membrane
M655_002675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M655_002680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M655_002685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M655_002690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M655_002695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M655_002705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M655_002710	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M655_002715	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M655_002720	COG0649	NAD binding
M655_002725	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M655_002730	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M655_002740	COG0713	ATP synthesis coupled electron transport
M655_002745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M655_002750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M655_002755	COG1007	ATP synthesis coupled electron transport
M655_002770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M655_002775	COG2385	sporulation resulting in formation of a cellular spore
M655_002780	COG0739	heme binding
M655_002785	COG1609	Transcriptional regulator
M655_002795	COG4786	Flagellar basal body rod
M655_002815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M655_002820	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M655_002825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M655_002835	COG1739	Uncharacterized protein family UPF0029
M655_002845	COG2373	Large extracellular alpha-helical protein
M655_002850	COG0544	peptidyl-prolyl cis-trans isomerase activity
M655_002875	COG4974	Belongs to the 'phage' integrase family
M655_002880	COG1476	TRANSCRIPTIONal
M655_002900	COG2003	Belongs to the UPF0758 family
M655_002925	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M655_002935	COG1215	transferase activity, transferring glycosyl groups
M655_002940	COG1011	Hydrolase
M655_002960	COG0697	spore germination
M655_002990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M655_002995	COG0726	polysaccharide deacetylase
M655_002995	COG1649	PFAM Uncharacterised BCR, COG1649
M655_003005	COG2197	response regulator
M655_003015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M655_003040	COG1256	bacterial-type flagellum assembly
M655_003040	COG4786	Flagellar basal body rod
M655_003045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M655_003055	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M655_003060	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M655_003075	COG1334	flagellar protein FlaG
M655_003080	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M655_003085	COG1516	flagellar protein fliS
M655_003120	COG0765	amino acid transport
M655_003125	COG1278	Cold shock
M655_003135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M655_003140	COG0653	protein targeting
M655_003170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M655_003175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M655_003180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M655_003185	COG0505	Belongs to the CarA family
M655_003195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M655_003205	COG2199	diguanylate cyclase activity
M655_003205	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M655_003215	COG0137	argininosuccinate synthase activity
M655_003220	COG0165	Argininosuccinate lyase
M655_003225	COG0814	amino acid
M655_003230	COG1979	alcohol dehydrogenase
M655_003235	COG2884	Cell division ATP-binding protein ftsE
M655_003240	COG2177	Part of the ABC transporter FtsEX involved in
M655_003245	COG0739	heme binding
M655_003250	COG3409	Peptidoglycan-binding domain 1 protein
M655_003250	COG0793	Belongs to the peptidase S41A family
M655_003255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M655_003270	COG0556	nucleotide-excision repair
M655_003275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M655_003280	COG1418	mRNA catabolic process
M655_003285	COG1950	PFAM Membrane protein of
M655_003295	COG2205	protein histidine kinase activity
M655_003300	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M655_003305	COG0110	maltose O-acetyltransferase activity
M655_003310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M655_003320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M655_003325	COG0131	Imidazoleglycerol-phosphate dehydratase
M655_003330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M655_003335	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M655_003340	COG0107	imidazoleglycerol-phosphate synthase activity
M655_003345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M655_003345	COG0140	phosphoribosyl-ATP diphosphatase activity
M655_003350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M655_003400	COG0492	ferredoxin-NADP+ reductase activity
M655_003405	COG1660	Displays ATPase and GTPase activities
M655_003410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M655_003415	COG1481	regulation of sporulation
M655_003420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M655_003460	COG4191	Histidine kinase
M655_003470	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M655_003495	COG0126	phosphoglycerate kinase activity
M655_003500	COG0149	triose-phosphate isomerase activity
M655_003510	COG0148	phosphopyruvate hydratase activity
M655_003515	COG1120	ATPase activity
M655_003520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_003525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_003530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_003540	COG1595	DNA-templated transcription, initiation
M655_003545	COG0390	transport system, permease component
M655_003550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M655_003560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M655_003565	COG0557	exoribonuclease II activity
M655_003570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M655_003585	COG2508	Transcriptional regulator
M655_003595	COG2814	Major facilitator Superfamily
M655_003625	COG1609	Transcriptional regulator
M655_003630	COG0673	inositol 2-dehydrogenase activity
M655_003640	COG0431	NADPH-dependent FMN reductase
M655_003645	COG0196	riboflavin kinase activity
M655_003650	COG0196	riboflavin kinase activity
M655_003660	COG0191	fructose-bisphosphate aldolase activity
M655_003665	COG1609	Transcriptional regulator
M655_003670	COG1609	Transcriptional regulator
M655_003675	COG2814	Major facilitator Superfamily
M655_003680	COG0673	inositol 2-dehydrogenase activity
M655_003685	COG1012	belongs to the aldehyde dehydrogenase family
M655_003690	COG0205	6-phosphofructokinase activity
M655_003695	COG1063	alcohol dehydrogenase
M655_003700	COG3962	Belongs to the TPP enzyme family
M655_003705	COG1082	Xylose isomerase domain protein TIM barrel
M655_003710	COG3959	Transketolase, thiamine diphosphate binding domain
M655_003715	COG3958	Transketolase
M655_003720	COG3718	enzyme involved in inositol metabolism
M655_003730	COG0673	inositol 2-dehydrogenase activity
M655_003735	COG1129	ABC transporter
M655_003740	COG1172	Belongs to the binding-protein-dependent transport system permease family
M655_003745	COG1879	ABC-type sugar transport system periplasmic component
M655_003750	COG0673	inositol 2-dehydrogenase activity
M655_003755	COG1879	ABC-type sugar transport system periplasmic component
M655_003760	COG5278	phosphoserine phosphatase activity
M655_003760	COG0840	transmembrane signaling receptor activity
M655_003770	COG2801	Transposase and inactivated derivatives
M655_003810	COG0840	transmembrane signaling receptor activity
M655_003820	COG0165	Argininosuccinate lyase
M655_003830	COG0596	Alpha beta hydrolase
M655_003840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_003845	COG1120	ATPase activity
M655_003890	COG1595	DNA-templated transcription, initiation
M655_003915	COG1414	Transcriptional regulator
M655_003920	COG2323	membrane
M655_003930	COG5002	protein histidine kinase activity
M655_003940	COG1129	ABC transporter
M655_003945	COG4214	carbohydrate transport
M655_003955	COG0024	Methionine aminopeptidase
M655_003960	COG0519	Catalyzes the synthesis of GMP from XMP
M655_003990	COG4191	Histidine kinase
M655_004030	COG4895	conserved protein (DUF2196)
M655_004040	COG1510	regulation of RNA biosynthetic process
M655_004045	COG0517	IMP dehydrogenase activity
M655_004045	COG4175	Glycine betaine
M655_004095	COG1131	(ABC) transporter
M655_004110	COG0586	Pfam SNARE associated Golgi protein
M655_004120	COG1566	PFAM secretion protein HlyD family protein
M655_004125	COG2814	Major facilitator Superfamily
M655_004135	COG2304	oxidoreductase activity
M655_004175	COG2140	Oxalate decarboxylase
M655_004185	COG3226	Transcriptional regulator
M655_004200	COG1785	Belongs to the alkaline phosphatase family
M655_004205	COG1111	helicase
M655_004205	COG1205	dead DEAH box helicase
M655_004210	COG3359	exonuclease
M655_004230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_004240	COG2076	Multidrug Resistance protein
M655_004250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M655_004255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M655_004260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M655_004265	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M655_004270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_004275	COG0506	proline dehydrogenase activity
M655_004285	COG1131	(ABC) transporter
M655_004300	COG0714	Associated with various cellular activities
M655_004320	COG2132	Multicopper oxidase
M655_004325	COG2226	methyltransferase
M655_004330	COG0840	transmembrane signaling receptor activity
M655_004340	COG1131	(ABC) transporter
M655_004355	COG0697	spore germination
M655_004380	COG1028	Short-chain dehydrogenase reductase Sdr
M655_004400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M655_004410	COG2050	protein possibly involved in aromatic compounds catabolism
M655_004415	COG2050	protein possibly involved in aromatic compounds catabolism
M655_004420	COG1024	Enoyl-CoA hydratase
M655_004425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M655_004435	COG1024	Enoyl-CoA hydratase
M655_004440	COG1250	3-hydroxyacyl-CoA dehydrogenase
M655_004445	COG1250	3-hydroxyacyl-CoA dehydrogenase
M655_004455	COG0183	Belongs to the thiolase family
M655_004475	COG1172	Belongs to the binding-protein-dependent transport system permease family
M655_004485	COG0410	ABC transporter
M655_004495	COG0840	transmembrane signaling receptor activity
M655_004500	COG3396	Phenylacetate-CoA oxygenase
M655_004515	COG2151	metal-sulfur cluster biosynthetic enzyme
M655_004520	COG1012	belongs to the aldehyde dehydrogenase family
M655_004525	COG3336	cytochrome c oxidase
M655_004540	COG1612	heme a metabolic process
M655_004550	COG0420	3'-5' exonuclease activity
M655_004555	COG0419	ATPase involved in DNA repair
M655_004560	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M655_004570	COG2318	DinB family
M655_004575	COG0531	amino acid
M655_004585	COG0528	UMP kinase activity
M655_004590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M655_004590	COG0551	DNA topoisomerase type I activity
M655_004600	COG2828	Protein conserved in bacteria
M655_004605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M655_004610	COG1131	(ABC) transporter
M655_004615	COG0842	Transport permease protein
M655_004620	COG1309	transcriptional regulator
M655_004625	COG0788	formyltetrahydrofolate deformylase activity
M655_004655	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M655_004660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M655_004675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M655_004680	COG1098	S1 RNA binding domain
M655_004705	COG0583	DNA-binding transcription factor activity
M655_004710	COG1506	peptidase
M655_004715	COG4191	Histidine kinase
M655_004730	COG2201	protein-glutamate methylesterase activity
M655_004740	COG0477	Major facilitator Superfamily
M655_004755	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M655_004755	COG2508	Transcriptional regulator
M655_004760	COG0686	Belongs to the AlaDH PNT family
M655_004780	COG0167	dihydroorotate dehydrogenase activity
M655_004785	COG0310	cobalt ion transport
M655_004790	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
M655_004800	COG1122	ATPase activity
M655_004850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M655_004855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M655_004900	COG0306	phosphate transporter
M655_004905	COG1392	Phosphate transport regulator
M655_004910	COG1279	arginine transmembrane transporter activity
M655_004915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_004995	COG5577	PFAM Coat F domain
M655_005010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M655_005015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M655_005035	COG1131	(ABC) transporter
M655_005045	COG2911	Protein conserved in bacteria
M655_005045	COG1361	Conserved repeat domain
M655_005045	COG3266	domain, Protein
M655_005050	COG1024	Enoyl-CoA hydratase
M655_005050	COG1250	3-hydroxyacyl-CoA dehydrogenase
M655_005055	COG0183	Belongs to the thiolase family
M655_005060	COG1960	acyl-CoA dehydrogenase activity
M655_005075	COG0697	spore germination
M655_005080	COG0814	amino acid
M655_005090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M655_005095	COG0235	Class ii aldolase
M655_005100	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M655_005105	COG1850	ribulose-bisphosphate carboxylase activity
M655_005110	COG1595	DNA-templated transcription, initiation
M655_005120	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M655_005125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M655_005130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M655_005135	COG1132	(ABC) transporter
M655_005140	COG1132	(ABC) transporter
M655_005145	COG0477	Major facilitator Superfamily
M655_005150	COG2340	Cysteine-rich secretory protein family
M655_005160	COG0616	signal peptide processing
M655_005165	COG1126	abc transporter atp-binding protein
M655_005185	COG1393	Belongs to the ArsC family
M655_005190	COG0436	Aminotransferase
M655_005195	COG0509	glycine decarboxylation via glycine cleavage system
M655_005200	COG0840	transmembrane signaling receptor activity
M655_005220	COG1473	amidohydrolase
M655_005225	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M655_005230	COG0396	ATPase activity
M655_005235	COG0719	Fe-S assembly protein
M655_005240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M655_005245	COG0822	iron-sulfur transferase activity
M655_005250	COG0719	Fe-S assembly protein
M655_005275	COG0840	transmembrane signaling receptor activity
M655_005295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_005310	COG0697	spore germination
M655_005315	COG0697	spore germination
M655_005330	COG2268	Band 7 protein
M655_005340	COG0527	aspartate kinase activity
M655_005350	COG1801	Protein of unknown function DUF72
M655_005355	COG0730	response to heat
M655_005360	COG0737	Belongs to the 5'-nucleotidase family
M655_005370	COG3377	Domain of unknown function (DUF1805)
M655_005380	COG0598	Magnesium transport protein CorA
M655_005390	COG0840	transmembrane signaling receptor activity
M655_005425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M655_005425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M655_005435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M655_005435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M655_005500	COG0739	heme binding
M655_005505	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
M655_005510	COG0693	protein deglycase activity
M655_005515	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
M655_005520	COG0420	3'-5' exonuclease activity
M655_005525	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M655_005530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M655_005540	COG4470	Protein conserved in bacteria
M655_005550	COG1494	fructose-1,6-bisphosphatase
M655_005560	COG2445	Protein of unknown function DUF86
M655_005575	COG0647	UMP catabolic process
M655_005590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M655_005600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M655_005610	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M655_005615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M655_005620	COG0626	cystathionine gamma-synthase activity
M655_005625	COG4837	Protein of unknown function (DUF1462)
M655_005665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M655_005675	COG1252	NADH dehydrogenase
M655_005685	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M655_005695	COG0316	Belongs to the HesB IscA family
M655_005760	COG1252	NADH dehydrogenase
M655_005785	COG3584	3D domain protein
M655_005790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_005795	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M655_005805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M655_005810	COG1832	CoA-binding protein
M655_005815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M655_005855	COG0477	Major facilitator Superfamily
M655_005875	COG1175	transmembrane transport
M655_005880	COG0395	ABC-type sugar transport system, permease component
M655_005885	COG0456	acetyltransferase
M655_005890	COG1472	Belongs to the glycosyl hydrolase 3 family
M655_005895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M655_005915	COG0747	negative chemotaxis
M655_005930	COG0444	Belongs to the ABC transporter superfamily
M655_005935	COG4608	Belongs to the ABC transporter superfamily
M655_005950	COG1414	Transcriptional regulator
M655_005965	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M655_005985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_006010	COG0596	Alpha beta hydrolase
M655_006020	COG5002	protein histidine kinase activity
M655_006025	COG0745	RESPONSE REGULATOR receiver
M655_006035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M655_006045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_006065	COG0697	spore germination
M655_006070	COG0640	Transcriptional regulator
M655_006095	COG0095	Lipoate-protein ligase
M655_006105	COG0640	Transcriptional regulator
M655_006125	COG0697	spore germination
M655_006140	COG2814	Major facilitator Superfamily
M655_006145	COG0477	Major facilitator Superfamily
M655_006155	COG1028	Short-chain dehydrogenase reductase Sdr
M655_006160	COG3135	benzoate transporter
M655_006165	COG2204	response regulator
M655_006220	COG4638	Rieske (2fe-2S)
M655_006225	COG1012	belongs to the aldehyde dehydrogenase family
M655_006230	COG1125	glycine betaine transport
M655_006230	COG0517	IMP dehydrogenase activity
M655_006240	COG1732	Glycine betaine
M655_006255	COG0473	3-isopropylmalate dehydrogenase activity
M655_006260	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M655_006275	COG2197	response regulator
M655_006280	COG2843	Capsule synthesis protein
M655_006290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_006300	COG0601	transmembrane transport
M655_006310	COG0444	Belongs to the ABC transporter superfamily
M655_006315	COG4608	Belongs to the ABC transporter superfamily
M655_006320	COG5583	Uncharacterized small protein (DUF2292)
M655_006330	COG4166	transmembrane transport
M655_006340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M655_006345	COG5002	protein histidine kinase activity
M655_006350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M655_006365	COG2964	Protein conserved in bacteria
M655_006395	COG0531	amino acid
M655_006405	COG0662	Cupin 2, conserved barrel domain protein
M655_006425	COG0531	amino acid
M655_006430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M655_006440	COG1012	belongs to the aldehyde dehydrogenase family
M655_006450	COG3829	transcription factor binding
M655_006450	COG3290	protein histidine kinase activity
M655_006460	COG0813	purine-nucleoside phosphorylase activity
M655_006465	COG2814	Major facilitator Superfamily
M655_006485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M655_006500	COG1309	transcriptional regulator
M655_006530	COG5002	protein histidine kinase activity
M655_006535	COG0745	RESPONSE REGULATOR receiver
M655_006555	COG2084	Dehydrogenase
M655_006560	COG0628	permease
M655_006565	COG0745	RESPONSE REGULATOR receiver
M655_006570	COG5002	protein histidine kinase activity
M655_006585	COG4166	transmembrane transport
M655_006590	COG1607	acyl-coa hydrolase
M655_006610	COG0860	N-Acetylmuramoyl-L-alanine amidase
M655_006615	COG1357	PFAM Pentapeptide repeats (8 copies)
M655_006635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M655_006645	COG0720	synthase
M655_006650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M655_006660	COG3142	Participates in the control of copper homeostasis
M655_006680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M655_006730	COG0006	proline dipeptidase activity
M655_006735	COG4166	transmembrane transport
M655_006740	COG3829	transcription factor binding
M655_006740	COG3290	protein histidine kinase activity
M655_006745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M655_006750	COG3938	Belongs to the proline racemase family
M655_006760	COG1012	belongs to the aldehyde dehydrogenase family
M655_006765	COG3938	Belongs to the proline racemase family
M655_006790	COG1737	Transcriptional regulator
M655_006795	COG0363	glucosamine-6-phosphate deaminase activity
M655_006815	COG4129	membrane
M655_006830	COG0765	amino acid transport
M655_006835	COG1414	Transcriptional regulator
M655_006860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M655_006865	COG0583	DNA-binding transcription factor activity
M655_006880	COG1840	ABC-type Fe3 transport system, periplasmic component
M655_006885	COG3842	ATPase activity
M655_006890	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M655_006905	COG0165	Argininosuccinate lyase
M655_006910	COG2971	BadF BadG BcrA BcrD
M655_006915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M655_006920	COG2186	Transcriptional regulator
M655_006930	COG0778	Nitroreductase
M655_006965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_006970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_006975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_006990	COG2070	2-Nitropropane dioxygenase
M655_006995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M655_007005	COG2226	methyltransferase
M655_007005	COG3433	isochorismatase activity
M655_007005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M655_007015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M655_007020	COG1695	Transcriptional regulator
M655_007025	COG0542	response to heat
M655_007035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_007040	COG0697	spore germination
M655_007055	COG1177	transmembrane transport
M655_007065	COG0596	Alpha beta hydrolase
M655_007085	COG0318	PFAM AMP-dependent synthetase and ligase
M655_007115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M655_007130	COG0840	transmembrane signaling receptor activity
M655_007135	COG0346	lactoylglutathione lyase activity
M655_007150	COG1595	DNA-templated transcription, initiation
M655_007180	COG0531	amino acid
M655_007185	COG0697	spore germination
M655_007190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M655_007195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M655_007200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M655_007220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_007225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M655_007245	COG1473	amidohydrolase
M655_007250	COG0189	ligase activity
M655_007290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M655_007300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M655_007310	COG2814	Major facilitator Superfamily
M655_007320	COG0826	peptidase U32
M655_007325	COG4166	transmembrane transport
M655_007345	COG2357	RelA SpoT domain protein
M655_007350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M655_007355	COG1309	transcriptional regulator
M655_007370	COG0601	transmembrane transport
M655_007375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_007380	COG0444	Belongs to the ABC transporter superfamily
M655_007385	COG4608	Belongs to the ABC transporter superfamily
M655_007390	COG4166	transmembrane transport
M655_007410	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M655_007410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M655_007440	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M655_007445	COG3275	phosphorelay sensor kinase activity
M655_007450	COG3279	Response regulator of the LytR AlgR family
M655_007465	COG1966	Carbon starvation protein
M655_007480	COG0483	inositol monophosphate 1-phosphatase activity
M655_007485	COG3387	PFAM Glycoside hydrolase 15-related
M655_007500	COG0778	Nitroreductase
M655_007510	COG1126	abc transporter atp-binding protein
M655_007515	COG0765	amino acid transport
M655_007520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M655_007525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M655_007545	COG0488	(ABC) transporter
M655_007580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M655_007610	COG1131	(ABC) transporter
M655_007630	COG4565	transcriptional regulatory protein
M655_007635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M655_007640	COG0791	NLP P60 protein
M655_007645	COG0726	polysaccharide deacetylase
M655_007655	COG0129	dihydroxy-acid dehydratase activity
M655_007700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M655_007710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M655_007710	COG1587	Uroporphyrinogen-III synthase
M655_007715	COG0306	phosphate transporter
M655_007720	COG0175	sulfate reduction
M655_007725	COG2046	Belongs to the sulfate adenylyltransferase family
M655_007730	COG0529	Catalyzes the synthesis of activated sulfate
M655_007740	COG1674	ftsk spoiiie
M655_007745	COG2814	Major facilitator Superfamily
M655_007780	COG1316	TRANSCRIPTIONal
M655_007790	COG0489	protein tyrosine kinase activity
M655_007825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M655_007835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M655_007865	COG2207	Transcriptional regulator
M655_007875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M655_007880	COG1228	amidohydrolase
M655_007885	COG0010	Belongs to the arginase family
M655_007910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_007920	COG0656	L-ascorbic acid biosynthetic process
M655_007930	COG1414	Transcriptional regulator
M655_007955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M655_007955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M655_007980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M655_007985	COG1132	(ABC) transporter
M655_007990	COG0745	RESPONSE REGULATOR receiver
M655_007995	COG5002	protein histidine kinase activity
M655_008000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M655_008005	COG0314	molybdopterin synthase activity
M655_008020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M655_008025	COG0315	cyclic pyranopterin monophosphate synthase activity
M655_008030	COG2814	Major facilitator Superfamily
M655_008035	COG0436	Aminotransferase
M655_008060	COG3842	ATPase activity
M655_008070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_008095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M655_008105	COG1733	regulation of RNA biosynthetic process
M655_008125	COG2309	aminopeptidase activity
M655_008145	COG3118	belongs to the thioredoxin family
M655_008155	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M655_008155	COG1605	Chorismate mutase
M655_008170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M655_008175	COG0123	including yeast histone deacetylase and acetoin utilization protein
M655_008180	COG0517	IMP dehydrogenase activity
M655_008185	COG0454	-acetyltransferase
M655_008200	COG1396	sequence-specific DNA binding
M655_008205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M655_008220	COG2203	Gaf domain
M655_008220	COG2199	diguanylate cyclase activity
M655_008225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M655_008240	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M655_008250	COG2081	HI0933 family
M655_008260	COG1363	Peptidase, m42
M655_008295	COG4326	sporulation control protein
M655_008305	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M655_008320	COG0747	negative chemotaxis
M655_008335	COG0444	Belongs to the ABC transporter superfamily
M655_008340	COG4608	Belongs to the ABC transporter superfamily
M655_008345	COG4948	Mandelate Racemase Muconate Lactonizing
M655_008350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M655_008375	COG0300	oxidoreductase activity
M655_008385	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M655_008400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M655_008405	COG1388	LysM domain
M655_008405	COG3584	3D domain protein
M655_008410	COG1104	cysteine desulfurase activity
M655_008415	COG0301	tRNA thio-modification
M655_008420	COG0179	Fumarylacetoacetate (FAA) hydrolase
M655_008520	COG4191	Histidine kinase
M655_008525	COG0861	Integral membrane protein TerC family
M655_008530	COG0726	polysaccharide deacetylase
M655_008535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M655_008550	COG2323	membrane
M655_008560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M655_008575	COG3584	3D domain protein
M655_008575	COG1388	LysM domain
M655_008585	COG3874	Sporulation protein YtfJ
M655_008595	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M655_008610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M655_008620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M655_008635	COG0564	pseudouridine synthase activity
M655_008640	COG0179	Fumarylacetoacetate (FAA) hydrolase
M655_008645	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M655_008650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M655_008665	COG1309	transcriptional regulator
M655_008670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M655_008680	COG0024	Methionine aminopeptidase
M655_008685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M655_008705	COG0586	Pfam SNARE associated Golgi protein
M655_008715	COG3481	metal-dependent phosphohydrolase, HD sub domain
M655_008735	COG0653	protein targeting
M655_008740	COG2223	nitrite transmembrane transporter activity
M655_008750	COG1316	TRANSCRIPTIONal
M655_008765	COG0446	pyridine nucleotide-disulphide oxidoreductase
M655_008765	COG1902	pentaerythritol trinitrate reductase activity
M655_008775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M655_008780	COG2211	Major facilitator Superfamily
M655_008790	COG1131	(ABC) transporter
M655_008795	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M655_008815	COG1595	DNA-templated transcription, initiation
M655_008820	COG1061	Type III restriction enzyme res subunit
M655_008825	COG1253	flavin adenine dinucleotide binding
M655_008840	COG4120	Belongs to the binding-protein-dependent transport system permease family
M655_008845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M655_008845	COG1116	anion transmembrane transporter activity
M655_008850	COG0477	Major facilitator Superfamily
M655_008850	COG2814	Major facilitator Superfamily
M655_008855	COG4533	DNA binding
M655_008865	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M655_008880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M655_008895	COG0835	chemotaxis
M655_008910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_008920	COG0861	Integral membrane protein TerC family
M655_008950	COG0210	DNA helicase
M655_008955	COG1253	flavin adenine dinucleotide binding
M655_008960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M655_008965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M655_008975	COG0613	PHP domain protein
M655_008995	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M655_009005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M655_009030	COG0582	viral genome integration into host DNA
M655_009040	COG2856	Zn peptidase
M655_009055	COG1396	sequence-specific DNA binding
M655_009125	COG0210	DNA helicase
M655_009135	COG1484	DNA-dependent DNA replication
M655_009140	COG0305	Participates in initiation and elongation during chromosome replication
M655_009150	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M655_009220	COG2868	ribosomal protein
M655_009280	COG0393	Putative heavy-metal-binding
M655_009310	COG3778	Protein conserved in bacteria
M655_009350	COG5632	N-Acetylmuramoyl-L-alanine amidase
M655_009350	COG1388	LysM domain
M655_009350	COG3409	Peptidoglycan-binding domain 1 protein
M655_009380	COG1132	(ABC) transporter
M655_009385	COG0745	RESPONSE REGULATOR receiver
M655_009390	COG5002	protein histidine kinase activity
M655_009400	COG0501	Belongs to the peptidase M48B family
M655_009425	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M655_009485	COG0697	spore germination
M655_009490	COG1522	sequence-specific DNA binding
M655_009495	COG1011	Hydrolase
M655_009505	COG0653	protein targeting
M655_009520	COG1231	oxidoreductase activity
M655_009535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M655_009540	COG1193	negative regulation of DNA recombination
M655_009560	COG0456	acetyltransferase
M655_009560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M655_009570	COG0745	RESPONSE REGULATOR receiver
M655_009575	COG3850	Histidine kinase
M655_009575	COG5002	protein histidine kinase activity
M655_009585	COG3212	peptidase
M655_009590	COG1227	inorganic diphosphatase activity
M655_009595	COG0789	Transcriptional regulator
M655_009615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_009620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_009625	COG1120	ATPase activity
M655_009635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M655_009645	COG0860	N-Acetylmuramoyl-L-alanine amidase
M655_009670	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M655_009775	COG3328	transposase activity
M655_009790	COG4372	Transposase
M655_009865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_009870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_009915	COG2962	Rard protein
M655_009920	COG0351	phosphomethylpyrimidine kinase
M655_009925	COG0577	efflux transmembrane transporter activity
M655_009925	COG1136	(ABC) transporter
M655_009930	COG1136	(ABC) transporter
M655_009930	COG0577	efflux transmembrane transporter activity
M655_009935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M655_009945	COG4106	trans-aconitate 2-methyltransferase activity
M655_009960	COG2217	Heavy metal translocating P-type atpase
M655_009970	COG0716	FMN binding
M655_009975	COG2171	N-acyltransferase activity
M655_009980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M655_009985	COG1473	amidohydrolase
M655_010000	COG1705	Flagellar rod assembly protein muramidase FlgJ
M655_010020	COG2267	carboxylic ester hydrolase activity
M655_010035	COG0167	dihydroorotate dehydrogenase activity
M655_010040	COG1982	Orn Lys Arg decarboxylase major
M655_010050	COG4493	Belongs to the UPF0637 family
M655_010070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M655_010085	COG0386	Belongs to the glutathione peroxidase family
M655_010115	COG0626	cystathionine gamma-synthase activity
M655_010120	COG0626	cystathionine gamma-synthase activity
M655_010130	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M655_010155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M655_010160	COG2843	Capsule synthesis protein
M655_010185	COG1393	Belongs to the ArsC family
M655_010190	COG1024	Enoyl-CoA hydratase
M655_010200	COG0454	-acetyltransferase
M655_010205	COG0439	Biotin carboxylase
M655_010210	COG0511	ligase activity, forming carbon-carbon bonds
M655_010215	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M655_010220	COG1024	Enoyl-CoA hydratase
M655_010225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M655_010230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M655_010245	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M655_010250	COG3266	domain, Protein
M655_010250	COG2911	Protein conserved in bacteria
M655_010250	COG1361	Conserved repeat domain
M655_010260	COG2807	transmembrane transport
M655_010265	COG2186	Transcriptional regulator
M655_010270	COG0531	amino acid
M655_010275	COG0583	DNA-binding transcription factor activity
M655_010280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M655_010285	COG2001	Belongs to the MraZ family
M655_010290	COG0275	rRNA processing
M655_010305	COG0768	penicillin binding
M655_010315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M655_010320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M655_010325	COG0772	Belongs to the SEDS family
M655_010330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M655_010335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M655_010340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M655_010345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M655_010360	COG3856	small basic protein
M655_010365	COG0849	cell division
M655_010370	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M655_010380	COG1191	sigma factor activity
M655_010385	COG1191	sigma factor activity
M655_010390	COG1873	PFAM PRC-barrel domain
M655_010400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M655_010405	COG1799	cell septum assembly
M655_010410	COG0762	integral membrane protein
M655_010415	COG2302	S4 RNA-binding domain
M655_010420	COG3599	regulation of cell shape
M655_010425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M655_010435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M655_010440	COG4948	Mandelate Racemase Muconate Lactonizing
M655_010445	COG2814	Major facilitator Superfamily
M655_010450	COG0494	nUDIX hydrolase
M655_010455	COG0492	ferredoxin-NADP+ reductase activity
M655_010460	COG1316	TRANSCRIPTIONal
M655_010505	COG1657	PFAM Prenyltransferase squalene oxidase
M655_010515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M655_010515	COG0551	DNA topoisomerase type I activity
M655_010520	COG1842	Phage shock protein A
M655_010545	COG1543	Belongs to the glycosyl hydrolase 57 family
M655_010550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M655_010560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M655_010570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M655_010575	COG0564	pseudouridine synthase activity
M655_010590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M655_010600	COG0540	Belongs to the ATCase OTCase family
M655_010605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M655_010615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M655_010620	COG0284	orotidine-5'-phosphate decarboxylase activity
M655_010635	COG0640	Transcriptional regulator
M655_010645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M655_010665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M655_010670	COG0673	inositol 2-dehydrogenase activity
M655_010675	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M655_010685	COG0460	homoserine dehydrogenase
M655_010695	COG2843	Capsule synthesis protein
M655_010705	COG0494	nUDIX hydrolase
M655_010710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M655_010720	COG4846	Membrane protein involved in cytochrome C biogenesis
M655_010735	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
M655_010740	COG1547	Domain of unknown function (DUF309)
M655_010765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M655_010770	COG1024	Enoyl-CoA hydratase
M655_010790	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M655_010795	COG1561	YicC-like family, N-terminal region
M655_010800	COG2052	Domain of unknown function (DUF370)
M655_010805	COG0194	GDP metabolic process
M655_010810	COG1758	RNA polymerase activity
M655_010820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M655_010825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M655_010830	COG0242	peptide deformylase activity
M655_010835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M655_010840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M655_010840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M655_010845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M655_010850	COG0631	protein serine/threonine phosphatase activity
M655_010855	COG0515	serine threonine protein kinase
M655_010855	COG2815	serine threonine protein kinase
M655_010865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M655_010870	COG1714	RDD family
M655_010880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M655_010885	COG0765	amino acid transport
M655_010890	COG1126	abc transporter atp-binding protein
M655_010895	COG3859	Proton-coupled thiamine transporter YuaJ
M655_010905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M655_010910	COG1302	Protein conserved in bacteria
M655_010915	COG1461	Dihydroxyacetone kinase
M655_010920	COG1307	EDD domain protein, DegV family
M655_010930	COG1760	l-serine dehydratase
M655_010935	COG1760	l-serine dehydratase
M655_010940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M655_010960	COG3708	Transcriptional regulator
M655_010960	COG2207	Transcriptional regulator
M655_010965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M655_010980	COG4990	cell redox homeostasis
M655_011015	COG1132	(ABC) transporter
M655_011020	COG3209	COG3209 Rhs family protein
M655_011025	COG0477	Major facilitator Superfamily
M655_011030	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M655_011040	COG0583	DNA-binding transcription factor activity
M655_011045	COG5522	Integral membrane protein (intg_mem_TP0381)
M655_011060	COG1027	Aspartate ammonia-lyase
M655_011080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M655_011085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M655_011090	COG0438	transferase activity, transferring glycosyl groups
M655_011120	COG0714	Associated with various cellular activities
M655_011145	COG4632	Exopolysaccharide biosynthesis protein
M655_011145	COG5434	Belongs to the glycosyl hydrolase 28 family
M655_011150	COG0405	Gamma-glutamyltransferase
M655_011160	COG1876	peptidase activity
M655_011165	COG0681	Belongs to the peptidase S26 family
M655_011170	COG1846	Transcriptional regulator
M655_011185	COG2309	aminopeptidase activity
M655_011195	COG1755	Isoprenylcysteine carboxyl methyltransferase
M655_011200	COG3424	synthase
M655_011210	COG2211	Major facilitator Superfamily
M655_011215	COG3300	MHYT domain
M655_011215	COG5001	Diguanylate cyclase
M655_011225	COG0306	phosphate transporter
M655_011235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M655_011240	COG1793	dna ligase
M655_011240	COG3285	dna ligase
M655_011245	COG0697	spore germination
M655_011265	COG1793	dna ligase
M655_011285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M655_011290	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M655_011295	COG0742	ribosomal rna small subunit methyltransferase
M655_011300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M655_011305	COG3314	Sporulation integral membrane protein YlbJ
M655_011310	COG1752	Esterase of the alpha-beta hydrolase superfamily
M655_011315	COG3480	Lon protease (S16) C-terminal proteolytic domain
M655_011325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M655_011330	COG1349	DNA-binding transcription factor activity
M655_011350	COG4555	ABC transporter
M655_011355	COG1349	DNA-binding transcription factor activity
M655_011360	COG0416	fatty acid biosynthetic process
M655_011365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M655_011370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M655_011375	COG1028	Short-chain dehydrogenase reductase Sdr
M655_011380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M655_011385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M655_011395	COG1196	nuclear chromosome segregation
M655_011400	COG0552	protein localization to endoplasmic reticulum
M655_011405	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M655_011410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M655_011415	COG0228	four-way junction DNA binding
M655_011420	COG1837	Belongs to the UPF0109 family
M655_011435	COG0336	Belongs to the RNA methyltransferase TrmD family
M655_011440	COG0335	large ribosomal subunit rRNA binding
M655_011445	COG0681	Belongs to the peptidase S26 family
M655_011455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M655_011465	COG2257	FlhB HrpN YscU SpaS Family
M655_011480	COG3541	Predicted nucleotidyltransferase
M655_011495	COG0606	chelatase, subunit chli
M655_011505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M655_011515	COG3706	GGDEF domain
M655_011520	COG0393	Putative heavy-metal-binding
M655_011540	COG0045	succinate-CoA ligase (ADP-forming) activity
M655_011545	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M655_011550	COG0758	DNA mediated transformation
M655_011555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M655_011560	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M655_011565	COG4974	Belongs to the 'phage' integrase family
M655_011570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M655_011575	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M655_011580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M655_011585	COG1815	bacterial-type flagellum-dependent cell motility
M655_011590	COG1558	bacterial-type flagellum-dependent cell motility
M655_011595	COG1677	Flagellar hook-basal body complex protein FliE
M655_011600	COG1766	The M ring may be actively involved in energy transduction
M655_011605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M655_011615	COG1157	protein secretion by the type III secretion system
M655_011640	COG4786	Flagellar basal body rod
M655_011655	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M655_011660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M655_011660	COG1776	CheC inhibitor of MCP methylation
M655_011665	COG2201	protein-glutamate methylesterase activity
M655_011670	COG3190	flagellar
M655_011675	COG1338	Plays a role in the flagellum-specific transport system
M655_011680	COG1987	bacterial-type flagellum assembly
M655_011685	COG1684	flagellar biosynthetic protein fliR
M655_011690	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M655_011695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M655_011700	COG1419	protein localization to endoplasmic reticulum
M655_011705	COG0455	bacterial-type flagellum organization
M655_011710	COG2201	protein-glutamate methylesterase activity
M655_011715	COG0643	Histidine kinase
M655_011715	COG2198	Histidine kinase
M655_011720	COG0835	chemotaxis
M655_011725	COG1776	CheC inhibitor of MCP methylation
M655_011730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M655_011740	COG1191	sigma factor activity
M655_011765	COG0052	Belongs to the universal ribosomal protein uS2 family
M655_011770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M655_011775	COG0528	UMP kinase activity
M655_011780	COG0233	cytoplasmic translational termination
M655_011785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M655_011790	COG4589	Belongs to the CDS family
M655_011795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M655_011800	COG0750	zinc metalloprotease
M655_011805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M655_011810	COG0442	prolyl-tRNA aminoacylation
M655_011815	COG2176	DNA-directed DNA polymerase activity
M655_011820	COG0779	Required for maturation of 30S ribosomal subunits
M655_011825	COG0195	Participates in both transcription termination and antitermination
M655_011835	COG1358	cellular component organization or biogenesis
M655_011840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M655_011840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M655_011850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M655_011855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M655_011860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M655_011865	COG0196	riboflavin kinase activity
M655_011870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M655_011875	COG1185	polyribonucleotide nucleotidyltransferase activity
M655_011880	COG0726	polysaccharide deacetylase
M655_011885	COG0612	Peptidase, M16
M655_011895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M655_011900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M655_011905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M655_011910	COG0527	aspartate kinase activity
M655_011915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M655_011920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M655_011925	COG0740	serine-type endopeptidase activity
M655_011935	COG1674	ftsk spoiiie
M655_011935	COG4980	gas vesicle protein
M655_011940	COG2188	Transcriptional regulator
M655_011965	COG0739	heme binding
M655_011970	COG0612	Peptidase, M16
M655_011975	COG0612	Peptidase, M16
M655_011980	COG0300	oxidoreductase activity
M655_012000	COG1426	Protein conserved in bacteria
M655_012005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M655_012010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M655_012020	COG0513	Belongs to the DEAD box helicase family
M655_012025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M655_012030	COG2137	regulation of response to DNA damage stimulus
M655_012040	COG1692	metallophosphoesterase
M655_012045	COG2359	stage V sporulation protein S
M655_012055	COG0674	pyruvate-flavodoxin oxidoreductase activity
M655_012055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M655_012060	COG1013	pyruvate-flavodoxin oxidoreductase activity
M655_012065	COG3949	Membrane
M655_012070	COG1234	tRNA 3'-trailer cleavage
M655_012075	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M655_012085	COG0517	IMP dehydrogenase activity
M655_012095	COG0095	Lipoate-protein ligase
M655_012100	COG3693	PFAM glycoside hydrolase, family 10
M655_012105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M655_012110	COG4550	Control of competence regulator ComK, YlbF/YmcA
M655_012125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M655_012130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M655_012135	COG2136	Putative SAM-dependent methyltransferase
M655_012135	COG2521	methyltransferase
M655_012140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M655_012145	COG1923	regulation of RNA biosynthetic process
M655_012175	COG2764	glyoxalase bleomycin resistance protein dioxygenase
M655_012180	COG2814	Major facilitator Superfamily
M655_012190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M655_012200	COG0464	growth
M655_012210	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M655_012215	COG0789	Transcriptional regulator
M655_012220	COG0174	glutamine synthetase
M655_012230	COG0789	Transcriptional regulator
M655_012255	COG5566	PFAM Mor transcription activator
M655_012270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M655_012275	COG1388	LysM domain
M655_012275	COG3942	CHAP domain
M655_012280	COG4224	UPF0291 protein
M655_012285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M655_012290	COG3973	AAA domain
M655_012295	COG0316	Belongs to the HesB IscA family
M655_012325	COG0022	dehydrogenase e1 component
M655_012330	COG0508	dehydrogenase complex catalyzes the overall conversion of
M655_012360	COG0488	(ABC) transporter
M655_012370	COG5434	Belongs to the glycosyl hydrolase 28 family
M655_012370	COG4632	Exopolysaccharide biosynthesis protein
M655_012380	COG0833	amino acid
M655_012385	COG0515	serine threonine protein kinase
M655_012395	COG4848	Belongs to the UPF0354 family
M655_012420	COG2707	UPF0756 membrane protein
M655_012430	COG1028	Short-chain dehydrogenase reductase Sdr
M655_012450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M655_012455	COG0626	cystathionine gamma-synthase activity
M655_012460	COG1595	DNA-templated transcription, initiation
M655_012475	COG1131	(ABC) transporter
M655_012500	COG0187	DNA topoisomerase II activity
M655_012505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M655_012515	COG0778	Nitroreductase
M655_012520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M655_012525	COG0673	inositol 2-dehydrogenase activity
M655_012535	COG1846	Transcriptional regulator
M655_012540	COG2814	Major facilitator Superfamily
M655_012545	COG0464	growth
M655_012555	COG3835	regulator
M655_012560	COG1012	belongs to the aldehyde dehydrogenase family
M655_012565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M655_012570	COG1694	Mazg nucleotide pyrophosphohydrolase
M655_012575	COG1611	Belongs to the LOG family
M655_012600	COG0493	'glutamate synthase
M655_012605	COG0167	dihydroorotate dehydrogenase activity
M655_012630	COG1953	Uracil, thiamine, allantoin
M655_012635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M655_012640	COG3290	protein histidine kinase activity
M655_012645	COG4565	transcriptional regulatory protein
M655_012680	COG0352	thiamine-phosphate diphosphorylase activity
M655_012685	COG0352	thiamine-phosphate diphosphorylase activity
M655_012700	COG3852	Histidine kinase
M655_012710	COG2197	response regulator
M655_012715	COG4585	Histidine kinase
M655_012735	COG0785	Cytochrome C biogenesis protein
M655_012740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M655_012750	COG3093	addiction module antidote protein HigA
M655_012800	COG2207	Transcriptional regulator
M655_012845	COG1956	GAF domain-containing protein
M655_012850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M655_012875	COG4122	O-methyltransferase activity
M655_012900	COG0385	Bile acid
M655_012950	COG0482	sulfurtransferase activity
M655_012965	COG2819	hydrolase of the alpha beta superfamily
M655_012970	COG1780	Probably involved in ribonucleotide reductase function
M655_012975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M655_012980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M655_012985	COG1114	Component of the transport system for branched-chain amino acids
M655_012990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M655_012995	COG1607	acyl-coa hydrolase
M655_013010	COG2843	Capsule synthesis protein
M655_013020	COG0318	PFAM AMP-dependent synthetase and ligase
M655_013040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M655_013045	COG3858	chitin binding
M655_013045	COG1388	LysM domain
M655_013065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M655_013075	COG2104	thiamine diphosphate biosynthetic process
M655_013080	COG2022	thiamine diphosphate biosynthetic process
M655_013085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M655_013090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M655_013095	COG1116	anion transmembrane transporter activity
M655_013100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M655_013105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M655_013110	COG0640	Transcriptional regulator
M655_013115	COG5658	integral membrane protein
M655_013130	COG1131	(ABC) transporter
M655_013155	COG2027	D-alanyl-D-alanine carboxypeptidase
M655_013160	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M655_013165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M655_013175	COG1114	Component of the transport system for branched-chain amino acids
M655_013180	COG0697	spore germination
M655_013190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M655_013195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M655_013205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M655_013205	COG0069	glutamate synthase activity
M655_013210	COG3361	conserved protein (COG2071)
M655_013225	COG0697	spore germination
M655_013245	COG2340	Cysteine-rich secretory protein family
M655_013280	COG0753	catalase activity
M655_013330	COG4989	oxidoreductase activity
M655_013335	COG3604	Transcriptional regulator
M655_013370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_013370	COG2207	Transcriptional regulator
M655_013375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_013410	COG1250	3-hydroxyacyl-CoA dehydrogenase
M655_013425	COG4106	trans-aconitate 2-methyltransferase activity
M655_013430	COG1960	acyl-CoA dehydrogenase activity
M655_013455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M655_013470	COG3321	synthase
M655_013470	COG4221	oxidoreductase activity
M655_013470	COG0300	oxidoreductase activity
M655_013470	COG3321	synthase
M655_013470	COG4221	oxidoreductase activity
M655_013470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M655_013470	COG0300	oxidoreductase activity
M655_013470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M655_013485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M655_013490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M655_013500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M655_013525	COG0546	phosphoglycolate phosphatase activity
M655_013545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M655_013545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M655_013545	COG3321	synthase
M655_013545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_013545	COG1028	Short-chain dehydrogenase reductase Sdr
M655_013550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M655_013550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M655_013550	COG3321	synthase
M655_013550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_013550	COG1028	Short-chain dehydrogenase reductase Sdr
M655_013565	COG3321	synthase
M655_013565	COG1028	Short-chain dehydrogenase reductase Sdr
M655_013565	COG4221	oxidoreductase activity
M655_013565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M655_013570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_013570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M655_013570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M655_013570	COG1028	Short-chain dehydrogenase reductase Sdr
M655_013570	COG3321	synthase
M655_013580	COG0673	inositol 2-dehydrogenase activity
M655_013615	COG0250	Participates in transcription elongation, termination and antitermination
M655_013645	COG1132	(ABC) transporter
M655_013650	COG1132	(ABC) transporter
M655_013670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M655_013680	COG0813	purine-nucleoside phosphorylase activity
M655_013695	COG1686	Belongs to the peptidase S11 family
M655_013700	COG2357	RelA SpoT domain protein
M655_013705	COG0741	lytic transglycosylase activity
M655_013705	COG1196	nuclear chromosome segregation
M655_013705	COG0739	heme binding
M655_013725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M655_013755	COG0714	Associated with various cellular activities
M655_013760	COG3069	C4-dicarboxylate transmembrane transporter activity
M655_013770	COG1028	Short-chain dehydrogenase reductase Sdr
M655_013775	COG3949	Membrane
M655_013790	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M655_013825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_013830	COG1475	DNA binding
M655_013835	COG0019	diaminopimelate decarboxylase activity
M655_013845	COG4264	IucA IucC family
M655_013850	COG4264	IucA IucC family
M655_013855	COG2814	Major facilitator Superfamily
M655_013860	COG4264	IucA IucC family
M655_013865	COG2423	ornithine cyclodeaminase activity
M655_013890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M655_013895	COG2200	EAL domain
M655_013900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M655_013905	COG0798	PFAM Bile acid sodium symporter
M655_013910	COG0346	lactoylglutathione lyase activity
M655_013915	COG0640	Transcriptional regulator
M655_013940	COG1653	transport
M655_013950	COG1082	Xylose isomerase domain protein TIM barrel
M655_013960	COG5002	protein histidine kinase activity
M655_013970	COG1063	alcohol dehydrogenase
M655_013975	COG1012	belongs to the aldehyde dehydrogenase family
M655_013985	COG0784	Response regulator, receiver
M655_013990	COG4191	Histidine kinase
M655_014000	COG1115	amino acid carrier protein
M655_014030	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M655_014035	COG1737	Transcriptional regulator
M655_014040	COG1070	Carbohydrate kinase
M655_014060	COG0070	glutamate synthase
M655_014060	COG0069	glutamate synthase activity
M655_014060	COG0067	glutamate synthase
M655_014065	COG0583	DNA-binding transcription factor activity
M655_014070	COG0454	-acetyltransferase
M655_014070	COG0456	acetyltransferase
M655_014075	COG1464	Belongs to the NlpA lipoprotein family
M655_014080	COG2011	ABC-type metal ion transport system permease component
M655_014085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M655_014090	COG1473	amidohydrolase
M655_014095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M655_014100	COG1464	Belongs to the NlpA lipoprotein family
M655_014105	COG2011	ABC-type metal ion transport system permease component
M655_014110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M655_014115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M655_014120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M655_014130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M655_014135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M655_014140	COG2826	transposase and inactivated derivatives, IS30 family
M655_014145	COG3552	Protein containing von Willebrand factor type A (VWA) domain
M655_014160	COG3483	tryptophan 2,3-dioxygenase activity
M655_014165	COG0402	S-adenosylhomocysteine deaminase activity
M655_014170	COG0586	Pfam SNARE associated Golgi protein
M655_014175	COG0490	domain, Protein
M655_014180	COG0475	glutathione-regulated potassium exporter activity
M655_014205	COG0398	Pfam SNARE associated Golgi protein
M655_014240	COG0439	Biotin carboxylase
M655_014245	COG0511	ligase activity, forming carbon-carbon bonds
M655_014250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M655_014260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M655_014260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M655_014270	COG0511	ligase activity, forming carbon-carbon bonds
M655_014275	COG1309	transcriptional regulator
M655_014280	COG1876	peptidase activity
M655_014285	COG0385	Bile acid
M655_014295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M655_014295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M655_014300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M655_014305	COG4946	Tricorn protease homolog
M655_014305	COG1506	peptidase
M655_014305	COG0823	Involved in the tonB-independent uptake of proteins
M655_014310	COG0823	Involved in the tonB-independent uptake of proteins
M655_014310	COG1506	peptidase
M655_014315	COG4166	transmembrane transport
M655_014320	COG4608	Belongs to the ABC transporter superfamily
M655_014325	COG0444	Belongs to the ABC transporter superfamily
M655_014330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_014335	COG0601	transmembrane transport
M655_014345	COG0697	spore germination
M655_014350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M655_014360	COG2755	lipolytic protein G-D-S-L family
M655_014360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M655_014390	COG1199	ATP-dependent helicase activity
M655_014405	COG1164	Oligoendopeptidase f
M655_014410	COG2309	aminopeptidase activity
M655_014420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M655_014425	COG1984	allophanate hydrolase subunit 2
M655_014430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M655_014435	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M655_014440	COG1414	Transcriptional regulator
M655_014460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M655_014475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M655_014515	COG5002	protein histidine kinase activity
M655_014520	COG0745	RESPONSE REGULATOR receiver
M655_014530	COG3708	Transcriptional regulator
M655_014540	COG2378	regulation of single-species biofilm formation
M655_014550	COG4302	ethanolamine ammonia-lyase activity
M655_014565	COG1959	2 iron, 2 sulfur cluster binding
M655_014580	COG0537	adenosine 5'-monophosphoramidase activity
M655_014585	COG0492	ferredoxin-NADP+ reductase activity
M655_014590	COG3858	chitin binding
M655_014595	COG0456	acetyltransferase
M655_014605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_014625	COG3546	catalase activity
M655_014635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M655_014640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M655_014645	COG0791	NLP P60 protein
M655_014660	COG2720	vancomycin resistance protein
M655_014670	COG3848	Pyruvate phosphate dikinase
M655_014670	COG0574	Belongs to the PEP-utilizing enzyme family
M655_014675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_014685	COG2207	Transcriptional regulator
M655_014685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_014720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M655_014730	COG4684	Psort location CytoplasmicMembrane, score
M655_014735	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M655_014740	COG1122	ATPase activity
M655_014745	COG1122	ATPase activity
M655_014750	COG3290	protein histidine kinase activity
M655_014750	COG3829	transcription factor binding
M655_014765	COG0456	acetyltransferase
M655_014770	COG3153	acetyltransferase
M655_014770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M655_014785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M655_014795	COG2508	Transcriptional regulator
M655_014805	COG0488	(ABC) transporter
M655_014815	COG4208	sulfate ABC transporter
M655_014825	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M655_014845	COG0756	dUTP diphosphatase activity
M655_014865	COG0546	phosphoglycolate phosphatase activity
M655_014870	COG0154	amidase activity
M655_014890	COG3048	D-serine ammonia-lyase activity
M655_014895	COG0456	acetyltransferase
M655_014925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M655_014935	COG0564	pseudouridine synthase activity
M655_014940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M655_014945	COG0583	DNA-binding transcription factor activity
M655_014950	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M655_014955	COG0066	3-isopropylmalate dehydratase activity
M655_014965	COG0318	PFAM AMP-dependent synthetase and ligase
M655_014975	COG1666	GTP binding
M655_014980	COG1028	Short-chain dehydrogenase reductase Sdr
M655_014995	COG1164	Oligoendopeptidase f
M655_015000	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M655_015005	COG0438	transferase activity, transferring glycosyl groups
M655_015010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_015015	COG0463	Glycosyl transferase, family 2
M655_015025	COG0438	transferase activity, transferring glycosyl groups
M655_015035	COG3935	DnaD domain protein
M655_015040	COG0017	Asparaginyl-tRNA synthetase
M655_015055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M655_015075	COG0402	S-adenosylhomocysteine deaminase activity
M655_015080	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M655_015090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M655_015090	COG1199	ATP-dependent helicase activity
M655_015100	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M655_015105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M655_015110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M655_015115	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M655_015115	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M655_015120	COG0617	tRNA 3'-terminal CCA addition
M655_015125	COG0438	transferase activity, transferring glycosyl groups
M655_015130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M655_015135	COG1803	Methylglyoxal synthase
M655_015140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M655_015145	COG1694	Mazg nucleotide pyrophosphohydrolase
M655_015150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M655_015170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M655_015205	COG1595	DNA-templated transcription, initiation
M655_015215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M655_015220	COG0287	Prephenate dehydrogenase
M655_015225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M655_015230	COG0159	tryptophan synthase activity
M655_015235	COG0133	tryptophan synthase activity
M655_015240	COG0135	phosphoribosylanthranilate isomerase activity
M655_015245	COG0134	indole-3-glycerol-phosphate synthase activity
M655_015250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M655_015265	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M655_015270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M655_015275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M655_015280	COG0105	UTP biosynthetic process
M655_015285	COG0142	geranyltranstransferase activity
M655_015300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M655_015305	COG2226	methyltransferase
M655_015310	COG0142	geranyltranstransferase activity
M655_015325	COG0741	lytic transglycosylase activity
M655_015340	COG4372	Transposase
M655_015375	COG3328	transposase activity
M655_015395	COG0302	gtp cyclohydrolase
M655_015400	COG0776	regulation of translation
M655_015405	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M655_015440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M655_015445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M655_015450	COG1160	GTP binding
M655_015470	COG1304	FMN binding
M655_015475	COG0539	negative regulation of cytoplasmic translation
M655_015500	COG2959	enzyme of heme biosynthesis
M655_015505	COG3773	Cell wall hydrolase
M655_015505	COG3409	Peptidoglycan-binding domain 1 protein
M655_015510	COG2339	peptidase activity
M655_015520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M655_015525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M655_015530	COG4862	establishment of competence for transformation
M655_015545	COG1388	LysM domain
M655_015555	COG0514	ATP-dependent DNA helicase (RecQ)
M655_015570	COG1141	Ferredoxin
M655_015575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M655_015580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M655_015595	COG0546	phosphoglycolate phosphatase activity
M655_015600	COG5002	protein histidine kinase activity
M655_015605	COG0745	RESPONSE REGULATOR receiver
M655_015610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M655_015615	COG1333	cytochrome c biogenesis protein
M655_015620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M655_015625	COG1187	pseudouridine synthase activity
M655_015630	COG0700	Nucleoside recognition
M655_015635	COG2715	membrane protein required for spore maturation
M655_015640	COG1686	Belongs to the peptidase S11 family
M655_015645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M655_015650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M655_015655	COG1994	Peptidase M50
M655_015660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M655_015665	COG3287	FIST C domain
M655_015665	COG2200	EAL domain
M655_015665	COG2199	diguanylate cyclase activity
M655_015670	COG0019	diaminopimelate decarboxylase activity
M655_015675	COG0697	spore germination
M655_015690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M655_015715	COG2172	sigma factor antagonist activity
M655_015725	COG1686	Belongs to the peptidase S11 family
M655_015730	COG0840	transmembrane signaling receptor activity
M655_015735	COG4608	Belongs to the ABC transporter superfamily
M655_015740	COG0444	Belongs to the ABC transporter superfamily
M655_015745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_015750	COG0601	transmembrane transport
M655_015755	COG4166	transmembrane transport
M655_015775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M655_015780	COG4974	Belongs to the 'phage' integrase family
M655_015790	COG0686	Belongs to the AlaDH PNT family
M655_015795	COG0735	belongs to the Fur family
M655_015800	COG1300	Membrane
M655_015805	COG1379	DNA repair
M655_015825	COG2195	Cleaves the N-terminal amino acid of tripeptides
M655_015830	COG0346	lactoylglutathione lyase activity
M655_015840	COG0508	dehydrogenase complex catalyzes the overall conversion of
M655_015845	COG0022	dehydrogenase e1 component
M655_015850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M655_015855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M655_015860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M655_015865	COG3290	protein histidine kinase activity
M655_015865	COG3829	transcription factor binding
M655_015900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M655_015910	COG2226	methyltransferase
M655_015920	COG1408	metallophosphoesterase
M655_015925	COG0288	reversible hydration of carbon dioxide
M655_015930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M655_015935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M655_015945	COG0750	zinc metalloprotease
M655_015950	COG0497	DNA recombination
M655_015955	COG1438	arginine binding
M655_015960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M655_015965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M655_015970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M655_015990	COG1570	exodeoxyribonuclease VII activity
M655_015995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M655_016005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M655_016020	COG1302	Protein conserved in bacteria
M655_016025	COG0439	Biotin carboxylase
M655_016030	COG0511	ligase activity, forming carbon-carbon bonds
M655_016070	COG3854	ATPases associated with a variety of cellular activities
M655_016085	COG1809	phosphosulfolactate synthase activity
M655_016090	COG2045	Belongs to the ComB family
M655_016095	COG2707	UPF0756 membrane protein
M655_016100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M655_016105	COG0006	proline dipeptidase activity
M655_016110	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M655_016120	COG3872	metal-dependent enzyme
M655_016130	COG1752	Esterase of the alpha-beta hydrolase superfamily
M655_016135	COG1321	iron dependent repressor
M655_016140	COG0431	NADPH-dependent FMN reductase
M655_016150	COG5002	protein histidine kinase activity
M655_016155	COG2234	aminopeptidase activity
M655_016165	COG0095	Lipoate-protein ligase
M655_016170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M655_016175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M655_016180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M655_016190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M655_016215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M655_016225	COG1910	domain protein
M655_016230	COG0725	ABC transporter, periplasmic molybdate-binding protein
M655_016235	COG4149	molybdate abc transporter
M655_016240	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M655_016245	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M655_016260	COG3679	Belongs to the UPF0342 family
M655_016285	COG3546	catalase activity
M655_016300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M655_016305	COG0191	fructose-bisphosphate aldolase activity
M655_016310	COG1028	Short-chain dehydrogenase reductase Sdr
M655_016320	COG3775	system Galactitol-specific IIC component
M655_016335	COG3279	Response regulator of the LytR AlgR family
M655_016340	COG1525	nuclease
M655_016355	COG0789	Transcriptional regulator
M655_016360	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M655_016370	COG0772	Belongs to the SEDS family
M655_016380	COG0028	Belongs to the TPP enzyme family
M655_016395	COG0387	Pfam Sodium calcium exchanger
M655_016400	COG0733	neurotransmitter:sodium symporter activity
M655_016405	COG4838	Belongs to the UPF0358 family
M655_016410	COG2066	Belongs to the glutaminase family
M655_016415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M655_016420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M655_016425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M655_016435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M655_016440	COG3829	transcription factor binding
M655_016445	COG0833	amino acid
M655_016455	COG0583	DNA-binding transcription factor activity
M655_016460	COG0671	phosphoesterase, PA-phosphatase related
M655_016465	COG1671	Belongs to the UPF0178 family
M655_016475	COG1404	Belongs to the peptidase S8 family
M655_016495	COG1234	tRNA 3'-trailer cleavage
M655_016500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M655_016505	COG1116	anion transmembrane transporter activity
M655_016510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M655_016515	COG0346	lactoylglutathione lyase activity
M655_016550	COG3739	integral membrane protein
M655_016560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_016560	COG2207	Transcriptional regulator
M655_016565	COG0604	alcohol dehydrogenase
M655_016570	COG0640	Transcriptional regulator
M655_016585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M655_016590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M655_016605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M655_016605	COG0646	methionine synthase
M655_016610	COG1410	methionine synthase
M655_016610	COG0646	methionine synthase
M655_016630	COG0018	arginyl-trna synthetase
M655_016640	COG0183	Belongs to the thiolase family
M655_016645	COG1126	abc transporter atp-binding protein
M655_016650	COG0765	amino acid transport
M655_016655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M655_016660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M655_016665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M655_016680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M655_016705	COG2199	diguanylate cyclase activity
M655_016705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M655_016710	COG0303	'Molybdopterin
M655_016715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M655_016720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M655_016725	COG5609	conserved protein (DUF2294)
M655_016735	COG2427	Protein of unknown function (DUF1641)
M655_016740	COG3383	formate dehydrogenase (NAD+) activity
M655_016745	COG1294	oxidase, subunit
M655_016750	COG1271	oxidase subunit
M655_016780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M655_016785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M655_016790	COG3162	membrane
M655_016795	COG3279	Response regulator of the LytR AlgR family
M655_016800	COG3275	phosphorelay sensor kinase activity
M655_016805	COG0367	asparagine synthase
M655_016815	COG0243	molybdopterin cofactor binding
M655_016830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M655_016845	COG0535	radical SAM domain protein
M655_016855	COG0477	Major facilitator Superfamily
M655_016865	COG3942	CHAP domain
M655_016865	COG1388	LysM domain
M655_016905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M655_016915	COG1119	ATPase activity
M655_016940	COG4294	response to UV
M655_016955	COG2986	histidine ammonia-lyase
M655_016960	COG3011	Protein conserved in bacteria
M655_016965	COG0667	Aldo Keto reductase
M655_016985	COG2154	pterin-4-alpha-carbinolamine dehydratase
M655_016995	COG1428	Deoxynucleoside kinase
M655_017000	COG1428	Deoxynucleoside kinase
M655_017015	COG1595	DNA-templated transcription, initiation
M655_017025	COG0351	phosphomethylpyrimidine kinase
M655_017030	COG3850	Histidine kinase
M655_017035	COG2197	response regulator
M655_017055	COG0701	Predicted permease
M655_017065	COG2072	flavoprotein involved in K transport
M655_017075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M655_017080	COG1408	metallophosphoesterase
M655_017085	COG3835	regulator
M655_017090	COG3842	ATPase activity
M655_017095	COG0561	phosphatase activity
M655_017100	COG2860	membrane
M655_017110	COG2249	NAD(P)H dehydrogenase (quinone) activity
M655_017130	COG1309	transcriptional regulator
M655_017150	COG3876	Protein conserved in bacteria
M655_017155	COG0318	PFAM AMP-dependent synthetase and ligase
M655_017165	COG1012	belongs to the aldehyde dehydrogenase family
M655_017170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M655_017175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M655_017180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M655_017185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M655_017195	COG0456	acetyltransferase
M655_017205	COG0584	glycerophosphoryl diester phosphodiesterase
M655_017210	COG1242	4 iron, 4 sulfur cluster binding
M655_017280	COG3568	Endonuclease Exonuclease Phosphatase
M655_017290	COG3409	Peptidoglycan-binding domain 1 protein
M655_017290	COG0793	Belongs to the peptidase S41A family
M655_017300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M655_017305	COG2384	SAM-dependent methyltransferase
M655_017310	COG1960	acyl-CoA dehydrogenase activity
M655_017320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M655_017325	COG0358	DNA primase activity
M655_017330	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M655_017335	COG0517	IMP dehydrogenase activity
M655_017340	COG0751	glycine-tRNA ligase activity
M655_017345	COG0752	glycyl-tRNA synthetase alpha subunit
M655_017355	COG1381	Involved in DNA repair and RecF pathway recombination
M655_017365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M655_017380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M655_017385	COG1702	phosphate starvation-inducible protein PhoH
M655_017415	COG4864	UPF0365 protein
M655_017420	COG1030	water channel activity
M655_017425	COG1610	YqeY-like protein
M655_017430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M655_017435	COG0537	adenosine 5'-monophosphoramidase activity
M655_017440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M655_017445	COG1181	Belongs to the D-alanine--D-alanine ligase family
M655_017460	COG1283	sodium-dependent phosphate transmembrane transporter activity
M655_017465	COG1346	cytolysis
M655_017470	COG1380	Effector of murein hydrolase LrgA
M655_017475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M655_017485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M655_017490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M655_017495	COG2264	protein methyltransferase activity
M655_017505	COG0443	Heat shock 70 kDa protein
M655_017515	COG1420	regulation of RNA biosynthetic process
M655_017520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M655_017525	COG0481	GTPase activity
M655_017530	COG0537	adenosine 5'-monophosphoramidase activity
M655_017535	COG0456	acetyltransferase
M655_017550	COG2226	methyltransferase
M655_017555	COG1120	ATPase activity
M655_017560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_017570	COG0006	proline dipeptidase activity
M655_017575	COG0596	Alpha beta hydrolase
M655_017590	COG0747	negative chemotaxis
M655_017595	COG4608	Belongs to the ABC transporter superfamily
M655_017600	COG0444	Belongs to the ABC transporter superfamily
M655_017610	COG0860	N-Acetylmuramoyl-L-alanine amidase
M655_017620	COG0268	Binds directly to 16S ribosomal RNA
M655_017625	COG1466	dna polymerase III delta subunit
M655_017640	COG2333	competence protein COMEC
M655_017640	COG0658	competence protein
M655_017645	COG0367	asparagine synthase
M655_017650	COG1555	photosystem II stabilization
M655_017650	COG1596	polysaccharide export
M655_017655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M655_017660	COG0495	leucyl-tRNA aminoacylation
M655_017665	COG2226	methyltransferase
M655_017670	COG0799	negative regulation of ribosome biogenesis
M655_017675	COG1713	HD superfamily hydrolase involved in NAD metabolism
M655_017680	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M655_017685	COG1534	Rna-binding protein
M655_017690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M655_017695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M655_017700	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M655_017705	COG1309	transcriptional regulator
M655_017725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M655_017730	COG0450	alkyl hydroperoxide reductase
M655_017735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M655_017740	COG4166	transmembrane transport
M655_017760	COG1413	lyase activity
M655_017795	COG1376	ErfK ybiS ycfS ynhG family protein
M655_017805	COG0488	(ABC) transporter
M655_017810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M655_017825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M655_017830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M655_017835	COG3336	cytochrome c oxidase
M655_017840	COG1999	signal sequence binding
M655_017860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M655_017865	COG2843	Capsule synthesis protein
M655_017875	COG1329	Transcriptional regulator
M655_017920	COG2201	protein-glutamate methylesterase activity
M655_017955	COG2199	diguanylate cyclase activity
M655_017955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M655_017960	COG4974	Belongs to the 'phage' integrase family
M655_017990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M655_017990	COG2199	diguanylate cyclase activity
M655_018000	COG0768	penicillin binding
M655_018005	COG0572	uridine kinase
M655_018010	COG4122	O-methyltransferase activity
M655_018015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M655_018020	COG2610	gluconate transmembrane transporter activity
M655_018045	COG3906	Belongs to the UPF0473 family
M655_018050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M655_018055	COG4472	Bacterial protein of unknown function (DUF965)
M655_018060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M655_018065	COG0628	permease
M655_018070	COG0861	Integral membrane protein TerC family
M655_018090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M655_018095	COG0840	transmembrane signaling receptor activity
M655_018105	COG1104	cysteine desulfurase activity
M655_018110	COG1959	2 iron, 2 sulfur cluster binding
M655_018120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M655_018130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M655_018135	COG0124	histidyl-tRNA synthetase
M655_018140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M655_018145	COG0860	N-Acetylmuramoyl-L-alanine amidase
M655_018155	COG1490	D-aminoacyl-tRNA deacylase activity
M655_018160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M655_018165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M655_018170	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M655_018170	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M655_018175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M655_018180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M655_018180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M655_018185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M655_018185	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M655_018195	COG2244	polysaccharide biosynthetic process
M655_018200	COG2323	membrane
M655_018205	COG0598	Magnesium transport protein CorA
M655_018215	COG1862	Preprotein translocase
M655_018225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M655_018230	COG2385	sporulation resulting in formation of a cellular spore
M655_018230	COG2247	cell wall binding repeat
M655_018240	COG2255	four-way junction helicase activity
M655_018245	COG0632	four-way junction helicase activity
M655_018250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M655_018270	COG0737	Belongs to the 5'-nucleotidase family
M655_018280	COG1388	LysM domain
M655_018285	COG0077	Prephenate dehydratase
M655_018290	COG0083	homoserine kinase activity
M655_018295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M655_018300	COG0460	homoserine dehydrogenase
M655_018305	COG4492	Belongs to the UPF0735 family
M655_018310	COG1252	NADH dehydrogenase
M655_018325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M655_018335	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M655_018345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M655_018350	COG1530	ribonuclease E activity
M655_018355	COG1994	Peptidase M50
M655_018365	COG1278	Cold shock
M655_018370	COG0772	Belongs to the SEDS family
M655_018375	COG2894	cell division
M655_018380	COG0850	regulation of cytokinetic process
M655_018390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M655_018395	COG1792	Involved in formation and maintenance of cell shape
M655_018400	COG1077	Cell shape determining protein MreB Mrl
M655_018405	COG2003	Belongs to the UPF0758 family
M655_018410	COG0424	maF-like protein
M655_018425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M655_018430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M655_018435	COG0285	dihydrofolate synthase activity
M655_018440	COG0525	valine-tRNA ligase activity
M655_018475	COG1388	LysM domain
M655_018490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M655_018505	COG1695	Transcriptional regulator
M655_018510	COG0737	Belongs to the 5'-nucleotidase family
M655_018530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M655_018535	COG0113	porphobilinogen synthase activity
M655_018545	COG0181	hydroxymethylbilane synthase activity
M655_018550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M655_018555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M655_018565	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M655_018565	COG3291	Pkd domain containing protein
M655_018570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M655_018580	COG0470	DNA polymerase III
M655_018580	COG1067	ATP-dependent peptidase activity
M655_018585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M655_018590	COG0740	serine-type endopeptidase activity
M655_018595	COG0544	peptidyl-prolyl cis-trans isomerase activity
M655_018600	COG0622	Phosphoesterase
M655_018605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M655_018610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M655_018625	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M655_018630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M655_018650	COG3209	COG3209 Rhs family protein
M655_018700	COG2801	Transposase and inactivated derivatives
M655_018715	COG3344	reverse transcriptase
M655_018725	COG3209	COG3209 Rhs family protein
M655_018745	COG0583	DNA-binding transcription factor activity
M655_018770	COG4608	Belongs to the ABC transporter superfamily
M655_018775	COG0444	Belongs to the ABC transporter superfamily
M655_018780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_018785	COG0601	transmembrane transport
M655_018790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M655_018795	COG3290	protein histidine kinase activity
M655_018795	COG3829	transcription factor binding
M655_018800	COG4166	transmembrane transport
M655_018815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M655_018830	COG1216	Glycosyl transferase, family 2
M655_018830	COG1442	glycosyl transferase family 8
M655_018835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_018845	COG0275	rRNA processing
M655_018880	COG1216	Glycosyl transferase, family 2
M655_018890	COG2340	Cysteine-rich secretory protein family
M655_018900	COG1216	Glycosyl transferase, family 2
M655_018900	COG0463	Glycosyl transferase, family 2
M655_018930	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M655_018940	COG0006	proline dipeptidase activity
M655_018945	COG0583	DNA-binding transcription factor activity
M655_018955	COG5337	Spore coat protein CotH
M655_018965	COG3290	protein histidine kinase activity
M655_018970	COG1473	amidohydrolase
M655_018980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M655_018995	COG1940	carbohydrate kinase activity
M655_019015	COG0673	inositol 2-dehydrogenase activity
M655_019020	COG0395	ABC-type sugar transport system, permease component
M655_019025	COG1175	transmembrane transport
M655_019055	COG2197	response regulator
M655_019060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_019085	COG1846	Transcriptional regulator
M655_019090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M655_019095	COG1053	succinate dehydrogenase
M655_019100	COG2009	succinate dehydrogenase
M655_019105	COG1719	4-vinyl reductase, 4VR
M655_019115	COG0322	excinuclease ABC activity
M655_019145	COG0683	leucine binding
M655_019150	COG3118	belongs to the thioredoxin family
M655_019160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M655_019165	COG2086	electron transfer activity
M655_019170	COG1024	Enoyl-CoA hydratase
M655_019175	COG1309	transcriptional regulator
M655_019180	COG0318	PFAM AMP-dependent synthetase and ligase
M655_019185	COG1316	TRANSCRIPTIONal
M655_019190	COG0183	Belongs to the thiolase family
M655_019195	COG2264	protein methyltransferase activity
M655_019205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M655_019210	COG2244	polysaccharide biosynthetic process
M655_019250	COG0438	transferase activity, transferring glycosyl groups
M655_019250	COG0297	glycogen (starch) synthase activity
M655_019255	COG2362	D-Aminopeptidase
M655_019260	COG1278	Cold shock
M655_019265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M655_019275	COG3766	membrane
M655_019280	COG1193	negative regulation of DNA recombination
M655_019290	COG1691	(AIR) carboxylase
M655_019295	COG1606	tRNA processing
M655_019300	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M655_019310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M655_019320	COG1063	alcohol dehydrogenase
M655_019330	COG0583	DNA-binding transcription factor activity
M655_019335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M655_019340	COG0569	domain protein
M655_019350	COG0814	amino acid
M655_019360	COG0814	amino acid
M655_019365	COG0697	spore germination
M655_019380	COG3844	kynureninase activity
M655_019385	COG1942	4-Oxalocrotonate Tautomerase
M655_019415	COG1414	Transcriptional regulator
M655_019420	COG3326	Membrane
M655_019425	COG0586	Pfam SNARE associated Golgi protein
M655_019445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_019450	COG0473	3-isopropylmalate dehydrogenase activity
M655_019455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M655_019460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M655_019465	COG0440	acetolactate synthase activity
M655_019470	COG0028	Belongs to the TPP enzyme family
M655_019475	COG2046	Belongs to the sulfate adenylyltransferase family
M655_019480	COG0175	sulfate reduction
M655_019490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M655_019495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M655_019500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M655_019505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M655_019510	COG0840	transmembrane signaling receptor activity
M655_019515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M655_019525	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
M655_019540	COG1960	acyl-CoA dehydrogenase activity
M655_019545	COG0318	PFAM AMP-dependent synthetase and ligase
M655_019555	COG3773	Cell wall hydrolase
M655_019590	COG0477	Major facilitator Superfamily
M655_019595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M655_019610	COG0747	negative chemotaxis
M655_019630	COG1280	lysine exporter protein (LysE YggA)
M655_019635	COG2808	Putative FMN-binding domain
M655_019645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M655_019650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M655_019655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M655_019660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_019670	COG1028	Short-chain dehydrogenase reductase Sdr
M655_019705	COG0583	DNA-binding transcription factor activity
M655_019710	COG2807	transmembrane transport
M655_019720	COG2404	hydrolase activity, acting on ester bonds
M655_019725	COG0673	inositol 2-dehydrogenase activity
M655_019730	COG3832	glyoxalase III activity
M655_019735	COG0640	Transcriptional regulator
M655_019740	COG4474	Belongs to the UPF0398 family
M655_019745	COG2814	Major facilitator Superfamily
M655_019765	COG0456	acetyltransferase
M655_019800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M655_019805	COG0477	Major facilitator Superfamily
M655_019810	COG2358	TRAP transporter, solute receptor (TAXI family
M655_019815	COG2204	response regulator
M655_019820	COG3852	Histidine kinase
M655_019850	COG1609	Transcriptional regulator
M655_019865	COG1970	mechanosensitive ion channel activity
M655_019890	COG0577	efflux transmembrane transporter activity
M655_019890	COG1136	(ABC) transporter
M655_019895	COG1136	(ABC) transporter
M655_019900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M655_019905	COG5002	protein histidine kinase activity
M655_019910	COG0745	RESPONSE REGULATOR receiver
M655_019915	COG0778	Nitroreductase
M655_019920	COG1643	Atp-dependent helicase
M655_019935	COG0346	lactoylglutathione lyase activity
M655_019940	COG0330	HflC and HflK could
M655_019960	COG2814	Major facilitator Superfamily
M655_019965	COG0583	DNA-binding transcription factor activity
M655_019975	COG1132	(ABC) transporter
M655_019980	COG1132	(ABC) transporter
M655_019990	COG1414	Transcriptional regulator
M655_020000	COG0242	peptide deformylase activity
M655_020015	COG0788	formyltetrahydrofolate deformylase activity
M655_020025	COG0217	transcriptional regulatory protein
M655_020040	COG0803	Belongs to the bacterial solute-binding protein 9 family
M655_020045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M655_020050	COG1121	(ABC) transporter
M655_020055	COG1012	belongs to the aldehyde dehydrogenase family
M655_020065	COG1454	alcohol dehydrogenase
M655_020070	COG1113	amino acid transport
M655_020085	COG5002	protein histidine kinase activity
M655_020085	COG2205	protein histidine kinase activity
M655_020085	COG0784	Response regulator, receiver
M655_020090	COG0745	RESPONSE REGULATOR receiver
M655_020095	COG3300	MHYT domain
M655_020095	COG5001	Diguanylate cyclase
M655_020120	COG0326	Molecular chaperone. Has ATPase activity
M655_020125	COG0789	Transcriptional regulator
M655_020145	COG1846	Transcriptional regulator
M655_020150	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M655_020170	COG1132	(ABC) transporter
M655_020180	COG1129	ABC transporter
M655_020195	COG2207	Transcriptional regulator
M655_020235	COG0583	DNA-binding transcription factor activity
M655_020245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_020250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_020255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_020260	COG2814	Major facilitator Superfamily
M655_020270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_020270	COG2207	Transcriptional regulator
M655_020315	COG0318	PFAM AMP-dependent synthetase and ligase
M655_020320	COG4221	oxidoreductase activity
M655_020345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_020375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M655_020450	COG3328	transposase activity
M655_020470	COG0582	viral genome integration into host DNA
M655_020490	COG4932	domain protein
M655_020490	COG5492	domain, Protein
M655_020500	COG1484	DNA-dependent DNA replication
M655_020510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M655_020520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M655_020530	COG0237	dephospho-CoA kinase activity
M655_020535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M655_020540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M655_020540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M655_020545	COG2861	carbohydrate metabolic process
M655_020550	COG0860	N-Acetylmuramoyl-L-alanine amidase
M655_020565	COG2814	Major facilitator Superfamily
M655_020570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M655_020575	COG1566	PFAM secretion protein HlyD family protein
M655_020580	COG1846	Transcriptional regulator
M655_020585	COG2720	vancomycin resistance protein
M655_020595	COG0704	Plays a role in the regulation of phosphate uptake
M655_020600	COG5002	protein histidine kinase activity
M655_020605	COG0745	RESPONSE REGULATOR receiver
M655_020625	COG0039	L-malate dehydrogenase activity
M655_020630	COG0538	isocitrate dehydrogenase activity
M655_020635	COG0372	Belongs to the citrate synthase family
M655_020640	COG0628	permease
M655_020645	COG3030	protein affecting phage T7 exclusion by the F plasmid
M655_020650	COG0824	Thioesterase
M655_020665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M655_020720	COG0205	6-phosphofructokinase activity
M655_020725	COG0825	malonyl-CoA metabolic process
M655_020730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M655_020740	COG2186	Transcriptional regulator
M655_020745	COG0281	malic enzyme
M655_020750	COG0587	DNA-directed DNA polymerase activity
M655_020765	COG0640	Transcriptional regulator
M655_020770	COG4109	DRTGG domain
M655_020775	COG4399	Belongs to the UPF0754 family
M655_020785	COG0189	ligase activity
M655_020790	COG0189	ligase activity
M655_020825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M655_020835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M655_020845	COG0745	RESPONSE REGULATOR receiver
M655_020850	COG1215	transferase activity, transferring glycosyl groups
M655_020865	COG0450	alkyl hydroperoxide reductase
M655_020875	COG0492	ferredoxin-NADP+ reductase activity
M655_020885	COG3706	GGDEF domain
M655_020895	COG4191	Histidine kinase
M655_020900	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M655_020905	COG2971	BadF BadG BcrA BcrD
M655_020910	COG0395	ABC-type sugar transport system, permease component
M655_020915	COG1175	transmembrane transport
M655_020920	COG1653	transport
M655_020925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M655_020930	COG1737	Transcriptional regulator
M655_020935	COG0402	S-adenosylhomocysteine deaminase activity
M655_020945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M655_020965	COG1404	Belongs to the peptidase S8 family
M655_020990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_020995	COG1120	ATPase activity
M655_021000	COG0748	coenzyme F420 binding
M655_021030	COG1309	transcriptional regulator
M655_021035	COG0180	Tryptophanyl-tRNA synthetase
M655_021055	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M655_021090	COG0318	PFAM AMP-dependent synthetase and ligase
M655_021110	COG0583	DNA-binding transcription factor activity
M655_021115	COG1683	Conserved Protein
M655_021120	COG1072	(Pantothenic acid kinase))
M655_021135	COG0783	Belongs to the Dps family
M655_021140	COG1473	amidohydrolase
M655_021145	COG1619	proteins homologs of microcin C7 resistance protein MccF
M655_021155	COG4565	transcriptional regulatory protein
M655_021160	COG3290	protein histidine kinase activity
M655_021165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M655_021170	COG5002	protein histidine kinase activity
M655_021175	COG0745	RESPONSE REGULATOR receiver
M655_021185	COG1301	dicarboxylic acid transport
M655_021195	COG0490	domain, Protein
M655_021200	COG0475	glutathione-regulated potassium exporter activity
M655_021205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M655_021220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M655_021220	COG1648	precorrin-2 dehydrogenase activity
M655_021225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M655_021230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M655_021235	COG1492	cobalamin metabolic process
M655_021265	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M655_021290	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M655_021295	COG0406	alpha-ribazole phosphatase activity
M655_021300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M655_021310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M655_021315	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M655_021320	COG1846	Transcriptional regulator
M655_021340	COG0069	glutamate synthase activity
M655_021345	COG0450	alkyl hydroperoxide reductase
M655_021410	COG0784	Response regulator, receiver
M655_021415	COG4191	Histidine kinase
M655_021420	COG0765	amino acid transport
M655_021425	COG0765	amino acid transport
M655_021440	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M655_021450	COG2814	Major facilitator Superfamily
M655_021460	COG2814	Major facilitator Superfamily
M655_021480	COG1845	cytochrome c oxidase, subunit III
M655_021485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M655_021500	COG3180	Ammonia monooxygenase
M655_021505	COG0583	DNA-binding transcription factor activity
M655_021510	COG0861	Integral membrane protein TerC family
M655_021545	COG2719	SpoVR family
M655_021555	COG2363	Small membrane protein
M655_021565	COG3973	AAA domain
M655_021585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M655_021610	COG1763	Mo-molybdopterin cofactor biosynthetic process
M655_021620	COG3383	formate dehydrogenase (NAD+) activity
M655_021630	COG2223	nitrite transmembrane transporter activity
M655_021635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M655_021655	COG0840	transmembrane signaling receptor activity
M655_021670	COG1733	regulation of RNA biosynthetic process
M655_021690	COG2801	Transposase and inactivated derivatives
M655_021730	COG0483	inositol monophosphate 1-phosphatase activity
M655_021745	COG0833	amino acid
M655_021755	COG0583	DNA-binding transcription factor activity
M655_021760	COG1380	Effector of murein hydrolase LrgA
M655_021765	COG1346	cytolysis
M655_021770	COG0730	response to heat
M655_021790	COG0436	Aminotransferase
M655_021795	COG1522	sequence-specific DNA binding
M655_021810	COG1335	isochorismatase
M655_021830	COG3300	MHYT domain
M655_021830	COG5001	Diguanylate cyclase
M655_021875	COG1695	Transcriptional regulator
M655_021885	COG1126	abc transporter atp-binding protein
M655_021890	COG0765	amino acid transport
M655_021900	COG4912	Dna alkylation repair
M655_021910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M655_021915	COG1378	Sugar-specific transcriptional regulator TrmB
M655_021930	COG0840	transmembrane signaling receptor activity
M655_021955	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M655_021960	COG1468	defense response to virus
M655_021960	COG1518	maintenance of DNA repeat elements
M655_021965	COG0675	Transposase, IS605 OrfB family
M655_022000	COG2249	NAD(P)H dehydrogenase (quinone) activity
M655_022010	COG2718	Belongs to the UPF0229 family
M655_022015	COG2766	serine protein kinase
M655_022030	COG0546	phosphoglycolate phosphatase activity
M655_022050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M655_022060	COG0328	RNA-DNA hybrid ribonuclease activity
M655_022065	COG3382	B3 4 domain protein
M655_022070	COG2233	PERMEase
M655_022075	COG0492	ferredoxin-NADP+ reductase activity
M655_022080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_022100	COG1132	(ABC) transporter
M655_022105	COG4753	response regulator
M655_022105	COG2207	Transcriptional regulator
M655_022180	COG2826	transposase and inactivated derivatives, IS30 family
M655_022185	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M655_022210	COG3858	chitin binding
M655_022215	COG0735	belongs to the Fur family
M655_022220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M655_022225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M655_022230	COG2096	Adenosyltransferase
M655_022235	COG2226	methyltransferase
M655_022240	COG1363	Peptidase, m42
M655_022245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M655_022255	COG0546	phosphoglycolate phosphatase activity
M655_022260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M655_022265	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M655_022280	COG4555	ABC transporter
M655_022290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M655_022295	COG2738	Putative neutral zinc metallopeptidase
M655_022300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M655_022320	COG2814	Major facilitator Superfamily
M655_022325	COG1132	(ABC) transporter
M655_022330	COG3557	Belongs to the UPF0374 family
M655_022335	COG0456	acetyltransferase
M655_022340	COG1028	Short-chain dehydrogenase reductase Sdr
M655_022350	COG0840	transmembrane signaling receptor activity
M655_022370	COG1988	membrane-bound metal-dependent
M655_022380	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M655_022390	COG3384	dioxygenase
M655_022425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M655_022430	COG2197	response regulator
M655_022435	COG4585	Histidine kinase
M655_022440	COG4758	membrane
M655_022445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M655_022450	COG1842	Phage shock protein A
M655_022465	COG0745	RESPONSE REGULATOR receiver
M655_022475	COG2124	cytochrome p450
M655_022480	COG1268	BioY protein
M655_022500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M655_022575	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M655_022580	COG3842	ATPase activity
M655_022590	COG1840	ABC-type Fe3 transport system, periplasmic component
M655_022595	COG5002	protein histidine kinase activity
M655_022600	COG0745	RESPONSE REGULATOR receiver
M655_022605	COG2032	superoxide dismutase activity
M655_022610	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
M655_022615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M655_022625	COG1278	Cold shock
M655_022630	COG3192	ethanolamine utilization protein
M655_022640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M655_022645	COG2205	protein histidine kinase activity
M655_022650	COG0745	RESPONSE REGULATOR receiver
M655_022660	COG1131	(ABC) transporter
M655_022680	COG0824	Thioesterase
M655_022695	COG0697	spore germination
M655_022710	COG3850	Histidine kinase
M655_022710	COG5002	protein histidine kinase activity
M655_022715	COG0745	RESPONSE REGULATOR receiver
M655_022720	COG1114	Component of the transport system for branched-chain amino acids
M655_022725	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M655_022735	COG3829	transcription factor binding
M655_022735	COG3290	protein histidine kinase activity
M655_022740	COG0745	RESPONSE REGULATOR receiver
M655_022750	COG2133	pyrroloquinoline quinone binding
M655_022770	COG0784	Response regulator, receiver
M655_022775	COG2358	TRAP transporter, solute receptor (TAXI family
M655_022790	COG2996	Protein conserved in bacteria
M655_022815	COG0004	ammonium transporteR
M655_022830	COG1247	-acetyltransferase
M655_022835	COG0442	prolyl-tRNA aminoacylation
M655_022845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M655_022870	COG0166	Belongs to the GPI family
M655_022875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M655_022880	COG1136	(ABC) transporter
M655_022885	COG0577	efflux transmembrane transporter activity
M655_022920	COG1253	flavin adenine dinucleotide binding
M655_022935	COG2076	Multidrug Resistance protein
M655_022940	COG2076	Multidrug Resistance protein
M655_022945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M655_022960	COG0693	protein deglycase activity
M655_022965	COG1733	regulation of RNA biosynthetic process
M655_022970	COG1360	Flagellar Motor Protein
M655_022975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M655_022995	COG0840	transmembrane signaling receptor activity
M655_023015	COG0456	acetyltransferase
M655_023020	COG1346	cytolysis
M655_023030	COG0583	DNA-binding transcription factor activity
M655_023045	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M655_023050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M655_023055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M655_023060	COG2258	MOSC domain
M655_023065	COG1187	pseudouridine synthase activity
M655_023070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_023075	COG0697	spore germination
M655_023090	COG1968	undecaprenyl-diphosphatase activity
M655_023095	COG1132	(ABC) transporter
M655_023100	COG1132	(ABC) transporter
M655_023105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M655_023115	COG4637	Psort location Cytoplasmic, score
M655_023125	COG1609	Transcriptional regulator
M655_023150	COG1136	(ABC) transporter
M655_023160	COG0577	efflux transmembrane transporter activity
M655_023170	COG1473	amidohydrolase
M655_023180	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M655_023200	COG4166	transmembrane transport
M655_023240	COG2261	transglycosylase associated protein
M655_023245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M655_023260	COG0666	response to abiotic stimulus
M655_023270	COG2819	hydrolase of the alpha beta superfamily
M655_023275	COG2207	Transcriptional regulator
M655_023275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_023285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M655_023290	COG3152	Membrane
M655_023300	COG0673	inositol 2-dehydrogenase activity
M655_023310	COG1940	carbohydrate kinase activity
M655_023315	COG4608	Belongs to the ABC transporter superfamily
M655_023320	COG0444	Belongs to the ABC transporter superfamily
M655_023325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_023330	COG0601	transmembrane transport
M655_023335	COG0747	negative chemotaxis
M655_023340	COG0673	inositol 2-dehydrogenase activity
M655_023350	COG2197	response regulator
M655_023355	COG4585	Histidine kinase
M655_023360	COG3239	Fatty acid desaturase
M655_023375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_023380	COG2207	Transcriptional regulator
M655_023410	COG1136	(ABC) transporter
M655_023420	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M655_023430	COG0477	Major facilitator Superfamily
M655_023470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M655_023475	COG2165	general secretion pathway protein
M655_023490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M655_023525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M655_023535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M655_023540	COG3328	transposase activity
M655_023565	COG2801	Transposase and inactivated derivatives
M655_023600	COG2271	Major facilitator Superfamily
M655_023605	COG1609	Transcriptional regulator
M655_023610	COG1028	Short-chain dehydrogenase reductase Sdr
M655_023615	COG1312	Catalyzes the dehydration of D-mannonate
M655_023620	COG0800	Aldolase
M655_023625	COG1063	alcohol dehydrogenase
M655_023640	COG1012	belongs to the aldehyde dehydrogenase family
M655_023645	COG1027	Aspartate ammonia-lyase
M655_023650	COG1414	Transcriptional regulator
M655_023655	COG0477	Major facilitator Superfamily
M655_023665	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
M655_023710	COG0039	L-malate dehydrogenase activity
M655_023735	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
M655_023740	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
M655_023745	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
M655_023750	COG1012	belongs to the aldehyde dehydrogenase family
M655_023750	COG1454	alcohol dehydrogenase
M655_023765	COG0531	amino acid
M655_023780	COG1349	DNA-binding transcription factor activity
M655_023840	COG4282	regulation of fungal-type cell wall biogenesis
M655_023845	COG3328	transposase activity
M655_023930	COG2002	toxin-antitoxin pair type II binding
M655_023940	COG2199	diguanylate cyclase activity
M655_023940	COG2203	Gaf domain
M655_023975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M655_023990	COG0210	DNA helicase
M655_024015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M655_024020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M655_024055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M655_024060	COG1597	lipid kinase activity
M655_024065	COG1940	carbohydrate kinase activity
M655_024070	COG0697	spore germination
M655_024075	COG1668	transmembrane transport
M655_024080	COG4555	ABC transporter
M655_024100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M655_024105	COG0154	amidase activity
M655_024110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M655_024120	COG0688	phosphatidylethanolamine metabolic process
M655_024125	COG3300	MHYT domain
M655_024125	COG5001	Diguanylate cyclase
M655_024130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M655_024135	COG1012	belongs to the aldehyde dehydrogenase family
M655_024150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M655_024155	COG0210	DNA helicase
M655_024160	COG2720	vancomycin resistance protein
M655_024170	COG0531	amino acid
M655_024175	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M655_024180	COG4496	protein, YerC YecD
M655_024185	COG1470	cell adhesion involved in biofilm formation
M655_024190	COG0745	RESPONSE REGULATOR receiver
M655_024195	COG2770	Histidine kinase
M655_024195	COG2205	protein histidine kinase activity
M655_024205	COG0516	GMP reductase activity
M655_024205	COG0517	IMP dehydrogenase activity
M655_024225	COG2195	Cleaves the N-terminal amino acid of tripeptides
M655_024230	COG1177	transmembrane transport
M655_024240	COG3842	ATPase activity
M655_024245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M655_024305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_024325	COG0559	Belongs to the binding-protein-dependent transport system permease family
M655_024335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M655_024350	COG2814	Major facilitator Superfamily
M655_024355	COG0151	Belongs to the GarS family
M655_024375	COG3300	MHYT domain
M655_024375	COG5001	Diguanylate cyclase
M655_024385	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M655_024390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M655_024395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M655_024400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M655_024405	COG0047	phosphoribosylformylglycinamidine synthase activity
M655_024410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M655_024415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M655_024420	COG1979	alcohol dehydrogenase
M655_024425	COG2309	aminopeptidase activity
M655_024460	COG2304	oxidoreductase activity
M655_024495	COG2304	oxidoreductase activity
M655_024510	COG1459	type II secretion system
M655_024530	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M655_024550	COG0405	Gamma-glutamyltransferase
M655_024555	COG2059	Chromate
M655_024560	COG2059	Chromate
M655_024565	COG4608	Belongs to the ABC transporter superfamily
M655_024570	COG0444	Belongs to the ABC transporter superfamily
M655_024575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_024585	COG0747	negative chemotaxis
M655_024595	COG0590	tRNA wobble adenosine to inosine editing
M655_024600	COG0577	efflux transmembrane transporter activity
M655_024605	COG1136	(ABC) transporter
M655_024610	COG2205	protein histidine kinase activity
M655_024615	COG0745	RESPONSE REGULATOR receiver
M655_024620	COG1595	DNA-templated transcription, initiation
M655_024635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M655_024640	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M655_024645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M655_024665	COG2252	PERMEase
M655_024670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M655_024670	COG0519	Catalyzes the synthesis of GMP from XMP
M655_024675	COG1305	Transglutaminase-like
M655_024685	COG0714	Associated with various cellular activities
M655_024765	COG3299	homolog of phage Mu protein gp47
M655_024770	COG3628	GPW Gp25 family protein
M655_024950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M655_024955	COG0756	dUTP diphosphatase activity
M655_024960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M655_024975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M655_024990	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M655_025000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M655_025020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M655_025020	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M655_025085	COG1484	DNA-dependent DNA replication
M655_025145	COG4974	Belongs to the 'phage' integrase family
M655_025240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M655_025245	COG2340	Cysteine-rich secretory protein family
M655_025255	COG0805	protein transport
M655_025260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M655_025270	COG0521	Mo-molybdopterin cofactor biosynthetic process
M655_025270	COG0315	cyclic pyranopterin monophosphate synthase activity
M655_025275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M655_025280	COG0488	(ABC) transporter
M655_025295	COG0456	acetyltransferase
M655_025300	COG1214	PFAM Peptidase M22, glycoprotease
M655_025305	COG0802	atpase or kinase
M655_025310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M655_025315	COG3091	SprT-like family
M655_025330	COG2183	response to ionizing radiation
M655_025335	COG1191	sigma factor activity
M655_025340	COG2172	sigma factor antagonist activity
M655_025345	COG1366	Belongs to the anti-sigma-factor antagonist family
M655_025350	COG2208	phosphoserine phosphatase activity
M655_025355	COG2172	sigma factor antagonist activity
M655_025360	COG2337	Toxic component of a toxin-antitoxin (TA) module
M655_025365	COG0864	Transcriptional regulator
M655_025370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M655_025385	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M655_025390	COG0736	holo-[acyl-carrier-protein] synthase activity
M655_025405	COG0640	Transcriptional regulator
M655_025425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M655_025430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M655_025440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M655_025445	COG0581	inorganic phosphate transmembrane transporter activity
M655_025450	COG0573	inorganic phosphate transmembrane transporter activity
M655_025455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M655_025480	COG4166	transmembrane transport
M655_025485	COG4166	transmembrane transport
M655_025490	COG4166	transmembrane transport
M655_025505	COG4166	transmembrane transport
M655_025535	COG1316	TRANSCRIPTIONal
M655_025550	COG0667	Aldo Keto reductase
M655_025560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M655_025575	COG1999	signal sequence binding
M655_025580	COG0425	Belongs to the sulfur carrier protein TusA family
M655_025580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M655_025595	COG0640	Transcriptional regulator
M655_025605	COG0714	Associated with various cellular activities
M655_025630	COG4555	ABC transporter
M655_025645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M655_025655	COG1309	transcriptional regulator
M655_025660	COG1902	pentaerythritol trinitrate reductase activity
M655_025670	COG0372	Belongs to the citrate synthase family
M655_025675	COG0583	DNA-binding transcription factor activity
M655_025695	COG4533	DNA binding
M655_025705	COG0840	transmembrane signaling receptor activity
M655_025705	COG5278	phosphoserine phosphatase activity
M655_025710	COG0740	serine-type endopeptidase activity
M655_025725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M655_025730	COG1522	sequence-specific DNA binding
M655_025750	COG0475	glutathione-regulated potassium exporter activity
M655_025755	COG1929	Belongs to the glycerate kinase type-1 family
M655_025760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M655_025765	COG0523	cobalamin synthesis protein
M655_025785	COG0745	RESPONSE REGULATOR receiver
M655_025790	COG5002	protein histidine kinase activity
M655_025795	COG0778	Nitroreductase
M655_025800	COG1028	Short-chain dehydrogenase reductase Sdr
M655_025805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M655_025810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M655_025825	COG2197	response regulator
M655_025830	COG4585	Histidine kinase
M655_025860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M655_025865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M655_025870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M655_025870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M655_025870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M655_025875	COG1105	Belongs to the carbohydrate kinase PfkB family
M655_025880	COG1349	DNA-binding transcription factor activity
M655_025890	COG1971	Probably functions as a manganese efflux pump
M655_025910	COG2205	protein histidine kinase activity
M655_025920	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M655_025925	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M655_025935	COG5609	conserved protein (DUF2294)
M655_025940	COG3842	ATPase activity
M655_025945	COG4149	molybdate abc transporter
M655_025950	COG1840	ABC-type Fe3 transport system, periplasmic component
M655_025955	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M655_025970	COG2608	mercury ion transmembrane transporter activity
M655_025975	COG2217	Heavy metal translocating P-type atpase
M655_025980	COG2313	pseudouridylate synthase activity
M655_025985	COG1522	sequence-specific DNA binding
M655_025985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M655_025990	COG1846	Transcriptional regulator
M655_025995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M655_026000	COG2259	Doxx family
M655_026005	COG1741	Belongs to the pirin family
M655_026010	COG2814	Major facilitator Superfamily
M655_026015	COG0427	acetyl-CoA hydrolase
M655_026025	COG3829	transcription factor binding
M655_026025	COG3290	protein histidine kinase activity
M655_026030	COG1288	antiporter activity
M655_026035	COG1473	amidohydrolase
M655_026040	COG4948	Mandelate Racemase Muconate Lactonizing
M655_026050	COG4841	protein insertion into membrane
M655_026055	COG5002	protein histidine kinase activity
M655_026060	COG0745	RESPONSE REGULATOR receiver
M655_026080	COG1028	Short-chain dehydrogenase reductase Sdr
M655_026085	COG2610	gluconate transmembrane transporter activity
M655_026090	COG3829	transcription factor binding
M655_026090	COG3290	protein histidine kinase activity
M655_026105	COG0778	Nitroreductase
M655_026110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_026115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M655_026120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_026125	COG2207	Transcriptional regulator
M655_026125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M655_026130	COG1388	LysM domain
M655_026130	COG4641	Protein conserved in bacteria
M655_026135	COG4641	Protein conserved in bacteria
M655_026135	COG1388	LysM domain
M655_026145	COG4172	Belongs to the ABC transporter superfamily
M655_026190	COG2217	Heavy metal translocating P-type atpase
M655_026205	COG3850	Histidine kinase
M655_026205	COG5002	protein histidine kinase activity
M655_026210	COG0745	RESPONSE REGULATOR receiver
M655_026215	COG0400	carboxylic ester hydrolase activity
M655_026220	COG0346	lactoylglutathione lyase activity
M655_026225	COG0778	Nitroreductase
M655_026250	COG0346	lactoylglutathione lyase activity
M655_026255	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M655_026260	COG2169	Transcriptional regulator
M655_026265	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M655_026270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M655_026285	COG1846	Transcriptional regulator
M655_026295	COG2197	response regulator
M655_026335	COG1063	alcohol dehydrogenase
M655_026345	COG1124	(ABC) transporter
M655_026350	COG0444	Belongs to the ABC transporter superfamily
M655_026360	COG0601	transmembrane transport
M655_026365	COG0747	negative chemotaxis
M655_026400	COG0456	acetyltransferase
M655_026410	COG2205	protein histidine kinase activity
M655_026415	COG5002	protein histidine kinase activity
M655_026425	COG2271	Major facilitator Superfamily
M655_026430	COG4608	Belongs to the ABC transporter superfamily
M655_026435	COG0444	Belongs to the ABC transporter superfamily
M655_026450	COG0747	negative chemotaxis
M655_026460	COG0583	DNA-binding transcription factor activity
M655_026550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M655_026555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M655_026565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M655_026570	COG5662	AntiSigma factor
M655_026575	COG1595	DNA-templated transcription, initiation
M655_026585	COG0010	Belongs to the arginase family
M655_026675	COG0726	polysaccharide deacetylase
M655_026680	COG2194	sulfuric ester hydrolase activity
M655_026690	COG0489	protein tyrosine kinase activity
M655_026695	COG0860	N-Acetylmuramoyl-L-alanine amidase
M655_026700	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M655_026705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M655_026710	COG0101	tRNA pseudouridine synthase activity
M655_026715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M655_026720	COG1122	ATPase activity
M655_026725	COG1122	ATPase activity
M655_026730	COG0203	ribosomal protein L17
M655_026735	COG0202	RNA polymerase activity
M655_026740	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M655_026745	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M655_026750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M655_026755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M655_026760	COG0024	Methionine aminopeptidase
M655_026765	COG0563	adenylate kinase activity
M655_026770	COG0201	protein transport
M655_026775	COG0200	Binds to the 23S rRNA
M655_026780	COG1841	ribosomal large subunit assembly
M655_026785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M655_026790	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M655_026795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M655_026800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M655_026805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M655_026810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M655_026815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M655_026820	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M655_026825	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M655_026830	COG0255	Belongs to the universal ribosomal protein uL29 family
M655_026835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M655_026840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M655_026845	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M655_026850	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M655_026855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M655_026860	COG0089	rRNA binding
M655_026865	COG0088	Forms part of the polypeptide exit tunnel
M655_026870	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M655_026875	COG0051	transcription antitermination factor activity, RNA binding
M655_026885	COG2346	COG2346, Truncated hemoglobins
M655_026890	COG0697	spore germination
M655_026895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M655_026900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M655_026905	COG0049	tRNA binding
M655_026910	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M655_026915	COG1358	cellular component organization or biogenesis
M655_026920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M655_026925	COG0085	RNA polymerase activity
M655_026930	COG2813	Specifically methylates the guanine in position
M655_026935	COG0222	ribosome binding
M655_026945	COG0081	regulation of translation
M655_026950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M655_026955	COG0250	Participates in transcription elongation, termination and antitermination
M655_026965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M655_026975	COG3688	RNA-binding protein containing a PIN domain
M655_026980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M655_026985	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M655_026990	COG0215	cysteine-tRNA ligase activity
M655_026995	COG1045	serine acetyltransferase
M655_027000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M655_027010	COG4956	integral membrane protein (PIN domain superfamily)
M655_027020	COG1183	phosphatidylcholine synthase activity
M655_027030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M655_027035	COG0542	response to heat
M655_027040	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M655_027045	COG3880	PFAM UvrB UvrC protein
M655_027090	COG0586	Pfam SNARE associated Golgi protein
M655_027120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M655_027125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M655_027130	COG1396	sequence-specific DNA binding
M655_027135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M655_027140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M655_027145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M655_027150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M655_027155	COG0805	protein transport
M655_027160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M655_027205	COG0512	Glutamine amidotransferase of anthranilate synthase
M655_027210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M655_027220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M655_027225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M655_027230	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M655_027235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M655_027240	COG4608	Belongs to the ABC transporter superfamily
M655_027250	COG4948	Mandelate Racemase Muconate Lactonizing
M655_027255	COG4166	transmembrane transport
M655_027260	COG0444	Belongs to the ABC transporter superfamily
M655_027265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M655_027270	COG0601	transmembrane transport
M655_027395	COG2894	cell division
M655_027475	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M655_027485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M655_027490	COG0735	belongs to the Fur family
M655_027495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M655_027500	COG1121	(ABC) transporter
M655_027505	COG0803	Belongs to the bacterial solute-binding protein 9 family
M655_027515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M655_027525	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component