locus-tag class description M654_000005 ENOG4105CRK lysyL-tRNA synthetase M654_000010 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) M654_000020 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase M654_000025 ENOG4105KRF dihydroneopterin aldolase M654_000030 ENOG4105EEI dihydropteroate synthase M654_000035 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 M654_000040 ENOG4105DDQ anthranilate synthase M654_000045 ENOG4105CRQ synthase (Component I) M654_000050 ENOG4105C6T cysteine synthase M654_000055 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase M654_000060 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) M654_000065 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) M654_000070 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) M654_000075 ENOG4108UGV hypoxanthine phosphoribosyltransferase M654_000120 ENOG41060GV RNA binding s1 domain protein M654_000135 ENOG4105VYY sporulation protein yabp M654_000140 ENOG41082I2 s4 domain protein M654_000145 ENOG4108IY2 MazG family M654_000155 ENOG4108M14 stage v sporulation protein t M654_000160 ENOG4108JA2 transcriptioN-repair coupling factor M654_000175 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) M654_000180 ENOG4105C5T Phosphoribosyl pyrophosphate synthase M654_000185 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) M654_000190 ENOG4105K4W Could be involved in septation (By similarity) M654_000195 ENOG4105KME endoribonuclease L-psp M654_000200 ENOG4105DFT pur operon repressor M654_000205 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) M654_000210 ENOG4105XEW small acid-soluble spore protein M654_000215 ENOG4105W42 Veg protein M654_000220 ENOG4105XFA sporulation peptidase YabG M654_000225 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) M654_000235 ENOG41069ER domain protein M654_000240 ENOG4105F8V Hydrolase, tatD family M654_000245 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) M654_000250 ENOG4105KRN Transcriptional regulator, abrb family M654_000255 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) M654_000260 ENOG4105VC4 domain protein M654_000265 ENOG41060K3 Methyltransferase M654_000270 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) M654_000275 ENOG4105MA4 psp1 domain protein M654_000280 ENOG4105FA2 dna polymerase iii M654_000285 ENOG4105XVJ Protein of unknown function (DUF327) M654_000290 ENOG4105X0R protein from nitrogen regulatory protein P-II M654_000295 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) M654_000300 ENOG4105CXN decarboxylase M654_000305 ENOG4105CDW Resistance protein M654_000330 ENOG4106DF1 M654_000355 ENOG41067KS pro-sigma K processing M654_000360 ENOG41067KS pro-sigma K processing M654_000370 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) M654_000375 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) M654_000380 ENOG4105C6E dna polymerase iii M654_000390 ENOG4108Z6B deaminase M654_000395 ENOG4105GTG Isochorismatase M654_000400 ENOG4105VRS hydrolase family 18 M654_000410 ENOG4105ZMH deoxynucleoside kinase M654_000425 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR M654_000430 ENOG4107QQ0 gntp family M654_000435 ENOG4105BZW Glycerate kinase M654_000440 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) M654_000445 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) M654_000450 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) M654_000460 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) M654_000500 ENOG41067KS pro-sigma K processing M654_000505 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M654_000510 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M654_000520 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) M654_000525 ENOG410848D S4 domain protein YaaA M654_000530 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) M654_000535 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) M654_000545 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) M654_000560 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) M654_000565 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) M654_000575 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) M654_000585 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) M654_000590 ENOG4107QJE Chromosome Partitioning Protein M654_000595 ENOG4105FA0 parb-like partition protein M654_000600 ENOG4108ZDA Sporulation protein YyaC M654_000610 ENOG4105VDK protein, conserved in bacteria M654_000615 ENOG4105C3G gtp-binding protein M654_000620 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) M654_000625 ENOG4108UUM single-stranded DNA-binding protein M654_000630 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) M654_000635 ENOG4108C33 Resolvase M654_000640 ENOG4105CHH sulfate transporter M654_000645 ENOG4107YZX Universal stress protein M654_000660 ENOG4105CHH sulfate transporter M654_000665 ENOG4107YZX Universal stress protein M654_000675 ENOG4108XMW Membrane M654_000680 ENOG4105BZR domain protein M654_000685 ENOG4105K9Q Binds to the 23S rRNA (By similarity) M654_000695 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate M654_000705 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) M654_000710 ENOG4105CE4 GlcNAc 6-P deacetylase M654_000720 ENOG4105DJ2 Major Facilitator Superfamily M654_000730 ENOG4105CDU Replicative dna helicase M654_000735 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis M654_000740 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) M654_000765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_000770 ENOG4105BZU Histidine kinase M654_000785 ENOG4105Q2H domain protein M654_000790 ENOG4105C0H protease M654_000805 ENOG4105WQG acetyltransferase M654_000820 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) M654_000855 ENOG4105VUF Transcriptional regulator M654_000880 ENOG4105BZU Histidine kinase M654_000885 ENOG4105KCT ABC transporter M654_000890 ENOG4108M15 ABC transporter M654_000905 ENOG4105EHG Permease protein M654_000910 ENOG4105DQ5 transport system permease protein M654_000930 ENOG4108JU3 Alkyl hydroperoxide reductase M654_000935 ENOG4105D3R alkyl hydroperoxide reductase M654_000940 ENOG4107R4J Chloride channel M654_000950 ENOG4105C0A alcohol dehydrogenase M654_000965 ENOG4105CMG Carbohydrate kinase M654_000980 ENOG41082J7 Rhodanese domain protein M654_000985 ENOG4105RV9 Transcriptional regulator M654_000990 ENOG4105E2R ROK family M654_000995 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase M654_001000 ENOG4105CMR udp-glucose 4-epimerase M654_001005 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) M654_001015 ENOG4107FKK extracellular solute-binding protein family 1 M654_001025 ENOG4105EG2 ABC transporter, permease M654_001050 ENOG4105DCF alanine dehydrogenase M654_001055 ENOG4105BZG amino acid carrier protein M654_001060 ENOG4105EC8 Methyl-accepting chemotaxis M654_001115 ENOG4108V5C ABC transporter M654_001125 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) M654_001130 ENOG4108MDK Dehydrogenase M654_001135 ENOG410667J hydrolase M654_001140 ENOG4105C5H ABC transporter M654_001145 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) M654_001155 ENOG4105CXY transporter M654_001160 ENOG4107VXM glycerophosphoryl diester phosphodiesterase M654_001165 ENOG4105CPC Aldo Keto reductase M654_001175 ENOG4105C26 Dehydrogenase M654_001180 ENOG4105DH8 myo-inositol catabolism M654_001185 ENOG4105D7K pfkb domain protein M654_001190 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) M654_001195 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) M654_001205 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) M654_001210 ENOG4105F0H myo-inositol catabolism protein M654_001215 ENOG4107TRN Xylose isomerase domain protein TIM barrel M654_001220 ENOG4105D2N Aldolase M654_001225 ENOG4108594 Permease of the drug metabolite transporter M654_001230 ENOG4105CPF Cell wall formation (By similarity) M654_001245 ENOG4105JKW Valine--pyruvate aminotransferase M654_001255 ENOG4107R8N Glycosyl transferase, family 2 M654_001260 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) M654_001290 ENOG4107RHR regulatoR M654_001295 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) M654_001300 ENOG4105D9N nucleoside M654_001305 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) M654_001320 ENOG4105C1J atp-dependent rna helicase M654_001325 ENOG4106Z5D Glycoside Hydrolase Family 43 M654_001335 ENOG4107QHE Choloylglycine hydrolase M654_001355 ENOG4105C5Y PTS System M654_001360 ENOG4105CS2 ec 3.2.1.21 M654_001370 ENOG4105EWM Histidine kinase M654_001375 ENOG4105C19 ABC transporter M654_001385 ENOG4105EDW glycosyl transferase, family 39 M654_001395 ENOG4107QP3 malate synthase g M654_001405 ENOG4105ETU transcriptional activator (TenA M654_001410 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein M654_001415 ENOG4108JJB ABC transporter M654_001420 ENOG4108W7F transporter, permease M654_001425 ENOG4105CID antiterminator M654_001430 ENOG4105C5Y PTS System M654_001435 ENOG4105CS2 ec 3.2.1.21 M654_001445 ENOG4105CH6 catalase M654_001455 ENOG4105VZ8 Transcriptional regulator M654_001485 ENOG4105CMR udp-glucose 4-epimerase M654_001490 ENOG4105CKK Glycosyl transferase, family 2 M654_001495 ENOG4105EDW glycosyl transferase, family 39 M654_001515 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) M654_001520 ENOG4105DT3 PTS system, galactitol-specific IIc component M654_001530 ENOG4105FB2 class II Aldolase M654_001550 ENOG4105ETE Transcriptional regulator (LacI family M654_001560 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M654_001565 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M654_001570 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) M654_001575 ENOG4107R3K hydrolase M654_001580 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) M654_001590 ENOG4105JVQ RNA Polymerase M654_001600 ENOG4105CK1 PTS System M654_001605 ENOG4105CS2 ec 3.2.1.21 M654_001610 ENOG4108FPN Integrase M654_001610 ENOG4108FPN Integrase M654_001630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_001655 ENOG4105C5B carbamate kinase M654_001665 ENOG4105DBV ornithine carbamoyltransferase M654_001670 ENOG4105CEU Arginine dihydrolase M654_001675 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) M654_001680 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) M654_001710 ENOG4105E0M Sulfatase M654_001735 ENOG4105X3H Excalibur domain protein M654_001740 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M654_001745 ENOG4105D2K citrate carrier protein M654_001750 ENOG4107QZ7 Cellulose synthase catalytic subunit M654_001760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_001765 ENOG4107BJW polysaccharide deacetylase M654_001775 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) M654_001780 ENOG4108IMY Transcriptional regulator M654_001785 ENOG4105HDK L-asparaginase M654_001790 ENOG4108IJ0 Aspartate ammonia-lyase M654_001795 ENOG4105DFD Na H antiporter M654_001810 ENOG4108QTI )-transporter M654_001820 ENOG4105C4M (Ubiquinol oxidase) subunit I M654_001825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii M654_001830 ENOG4108JJ9 ABC, transporter M654_001835 ENOG4108JJ8 (ABC) transporter M654_001845 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) M654_001855 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) M654_001870 ENOG4105CH6 catalase M654_001900 ENOG4105DA5 (ABC) transporter M654_001910 ENOG4105C2C drug resistance transporter, Bcr CflA M654_001925 ENOG4107TDE lipolytic protein G-D-S-L family M654_001930 ENOG4105BZ1 (ABC) transporter M654_001935 ENOG4105VUN Transcriptional regulator M654_001945 ENOG4105CR4 methylisocitrate lyase M654_001950 ENOG4105DXD 2-methylcitrate dehydratase M654_001970 ENOG4105C5E polysaccharide biosynthesis protein M654_001975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase M654_001980 ENOG4108VX5 3-methyladenine DNA glycosylase M654_001985 ENOG4105EMD TRANSCRIPTIONal M654_001990 ENOG4105VZJ PTS System M654_001995 ENOG4105CK1 PTS System M654_002000 ENOG4105VCP PTS System M654_002005 ENOG4105F8D glycoside hydrolase family 4 M654_002015 ENOG4105CM2 brancheD-chain amino acid aminotransferase M654_002020 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD M654_002025 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) M654_002030 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein M654_002035 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) M654_002050 ENOG4105D3W isochorismatase M654_002055 ENOG41080V3 Major Facilitator superfamily M654_002065 ENOG4105IIU Aminopeptidase M654_002070 ENOG4105J4Q Transcriptional regulator M654_002075 ENOG4105D7K pfkb domain protein M654_002080 ENOG4108UHU Aldolase M654_002085 ENOG4105CXK mandelate racemase muconate lactonizing M654_002090 ENOG4105DJB Major Facilitator Superfamily M654_002100 ENOG4105EYF MMPL domain protein M654_002105 ENOG4108VB1 regulatoR M654_002110 ENOG4105ENE Histidine kinase M654_002125 ENOG4105X1N Glycosyl transferase family 8 M654_002130 ENOG4105C5I Dehydrogenase M654_002140 ENOG4105DR4 Methyltransferase M654_002145 ENOG4105CK7 Sodium proline symporter M654_002150 ENOG41067MG lrgb family M654_002170 ENOG4105CMU LysR family (Transcriptional regulator M654_002175 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase M654_002180 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) M654_002190 ENOG4105C93 Xylose Isomerase M654_002195 ENOG4105CMG Carbohydrate kinase M654_002210 ENOG4108WS4 fmn reductase M654_002220 ENOG4105CMR udp-glucose 4-epimerase M654_002225 ENOG4105E2S oxidase) subunit II M654_002230 ENOG4105BZ9 Cytochrome C oxidase, subunit I M654_002240 ENOG41060D1 Quinol oxidase M654_002255 ENOG4105DWD nucleoside recognition domain protein M654_002270 ENOG4108DBC nitroreductase M654_002275 ENOG4105DEN Luciferase family M654_002285 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin M654_002300 ENOG4105C5Y PTS System M654_002315 ENOG4105DWF phosphomethylpyrimidine kinase M654_002320 ENOG4105H67 Protein of unknown function (DUF421) M654_002325 ENOG4108RJ9 Glycosyl transferase, family 2 M654_002330 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) M654_002350 ENOG4105WH1 Two component transcriptional regulator luxr family M654_002360 ENOG4105CJ1 ABC, transporter M654_002380 ENOG4105CZN Potassium uptake protein M654_002390 ENOG4107JTW chlorite dismutase M654_002395 ENOG4108IJ2 phosphate acetyltransferase M654_002405 ENOG4105J4Q Transcriptional regulator M654_002430 ENOG4105D2S major facilitator superfamily M654_002440 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) M654_002450 ENOG4108VCI transcription factor, rsfa family M654_002460 ENOG4105DCI Phosphohydrolase M654_002475 ENOG41069HH 4-oxalocrotonate tautomerase M654_002480 ENOG4108Z4T Peptidase M50 M654_002485 ENOG4108XFG YwhD family M654_002490 ENOG4105BZ4 penicillin-binding protein M654_002500 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) M654_002505 ENOG4105CYW agmatinase M654_002510 ENOG410684U Domain of unknown function (DUF1934) M654_002515 ENOG4105C75 arginyL-tRNA synthetase M654_002530 ENOG4105DF6 Fe-S oxidoreductase M654_002540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase M654_002545 ENOG4105C1G acyl-Coa dehydrogenase M654_002550 ENOG4105C1G acyl-Coa dehydrogenase M654_002560 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) M654_002570 ENOG410812K response regulator receiver protein M654_002575 ENOG4105D2N Aldolase M654_002580 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway M654_002585 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) M654_002590 ENOG4105CBT Fructose-1,6-bisphosphatase M654_002595 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) M654_002600 ENOG41082DI 50s ribosomal protein l31 M654_002605 ENOG4107104 thymidine kinase M654_002610 ENOG4105C6K Malic enzyme M654_002615 ENOG4107TT2 Auxin Efflux Carrier M654_002625 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase M654_002630 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) M654_002635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) M654_002640 ENOG4108ZXQ stage ii sporulation protein r M654_002650 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) M654_002655 ENOG410815N Probably functions as a manganese efflux pump (By similarity) M654_002660 ENOG4107WAU Protein tyrosine phosphatase M654_002665 ENOG4108YZG isomerase M654_002670 ENOG4108UIC UPF0340 protein M654_002675 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) M654_002680 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) M654_002690 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) M654_002705 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) M654_002710 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) M654_002715 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) M654_002720 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) M654_002725 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) M654_002730 ENOG4106778 Protein of unknown function (DUF1146) M654_002740 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) M654_002755 ENOG4108TF4 von Willebrand factor, type A M654_002770 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) M654_002775 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) M654_002790 ENOG4108Z40 Transcriptional regulator M654_002795 ENOG4108RYK Nad-dependent epimerase dehydratase M654_002800 ENOG4106BRK M654_002805 ENOG410874W AraC family transcriptional regulator M654_002825 ENOG4105NIV Esterase M654_002830 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase M654_002835 ENOG4105E4F Isochorismate synthase M654_002840 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase M654_002845 ENOG4105WQI isochorismatase M654_002850 ENOG4105CEY Amp-dependent synthetase and ligase M654_002855 ENOG4105WQT MbtH domain protein M654_002860 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_002865 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) M654_002875 ENOG4107TCE N-acetyltransferase M654_002880 ENOG4105FRN stage II sporulation protein M654_002885 ENOG4108KPJ rna polymerase sigma factor M654_002900 ENOG4105BZU Histidine kinase M654_002905 ENOG4105C37 (CBS) domain M654_002915 ENOG41080XP Cbs domain M654_002920 ENOG4108NA0 Uncharacterized conserved protein (COG2071) M654_002930 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase M654_002935 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase M654_002945 ENOG4105CZM Major Facilitator M654_002950 ENOG4107MII Sugar-specific transcriptional regulator TrmB M654_002960 ENOG4105MT0 Sporulation transcriptional regulator spoiiid M654_002965 ENOG4105DFF Rod shape-determining protein mreb M654_002975 ENOG4105CGA flagellar basal-body rod protein FlgG M654_002980 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) M654_003000 ENOG4105Z8H single-stranded DNA-binding protein M654_003005 ENOG4105DKT Transcriptional regulator M654_003015 ENOG410787A Pts system, glucitol sorbitol-specific M654_003020 ENOG4105DZY Pts system, glucitol sorbitol-specific M654_003030 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase M654_003040 ENOG4105E98 transcriptional regulator DeoR family M654_003045 ENOG410667J hydrolase M654_003050 ENOG4108XI2 Domain of unknown function (DUF1963) M654_003055 ENOG4105C0D helicase M654_003060 ENOG4105KBK Zinc finger, swim domain protein M654_003070 ENOG4105HTX biosynthesis protein M654_003075 ENOG4108RB3 Capsular polysaccharide biosynthesis protein M654_003080 ENOG4105C6Y Udp-glucose 6-dehydrogenase M654_003085 ENOG4105FGV Chromate M654_003090 ENOG4105CAH Chromate M654_003100 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) M654_003105 ENOG4107RSM transcriptional regulator M654_003115 ENOG4107FQX Alpha-acetolactate decarboxylase M654_003120 ENOG41089UC methyltransferase, type 11 M654_003125 ENOG4105C5Q Transcriptional regulator M654_003130 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M654_003135 ENOG4105CNN ABC, transporter M654_003140 ENOG4105C2J ABC transporter M654_003145 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) M654_003150 ENOG4108RVA ribokinase M654_003155 ENOG4105ETE Transcriptional regulator (LacI family M654_003160 ENOG4105N98 Capsule biosynthesis protein capB M654_003170 ENOG4105PNM synthesis protein M654_003175 ENOG4105K4H Nlp p60 protein M654_003180 ENOG4105J7I hydrolase M654_003185 ENOG4108KGH TRANSCRIPTIONal M654_003190 ENOG4105C54 Major Facilitator superfamily M654_003195 ENOG4105E2A Dehydrogenase M654_003200 ENOG4105CHR reductase M654_003210 ENOG4108M60 Transcriptional regulator M654_003215 ENOG4105D7K pfkb domain protein M654_003220 ENOG4108UHU Aldolase M654_003225 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) M654_003230 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase M654_003240 ENOG4105DG6 mannose-6-phosphate isomerase M654_003255 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) M654_003265 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase M654_003285 ENOG4105EY8 ABC transporter M654_003295 ENOG4107SJB teichoic acid biosynthesis M654_003300 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) M654_003305 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase M654_003315 ENOG4107RZX Teichoic acid biosynthesis protein M654_003320 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M654_003325 ENOG4108KGH TRANSCRIPTIONal M654_003335 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_003340 ENOG4105D3Q Sugar transferase M654_003345 ENOG4105PSV Polysaccharide Biosynthesis Protein M654_003350 ENOG4107RA4 Glycosyl transferase (Group 1 M654_003355 ENOG4105C6Y Udp-glucose 6-dehydrogenase M654_003360 ENOG4105C1B dTDP-glucose 4-6-dehydratase M654_003365 ENOG4105QZI O-Antigen Polymerase M654_003380 ENOG4107EF8 Glycosyl transferase (Group 1 M654_003385 ENOG4105ESV Glycosyl transferase, family 4 M654_003390 ENOG4108J53 cell adhesion domain-containing protein M654_003395 ENOG4108KGH TRANSCRIPTIONal M654_003400 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein M654_003405 ENOG4105BZU Histidine kinase M654_003410 ENOG4105WH1 Two component transcriptional regulator luxr family M654_003430 ENOG41081UC Inherit from COG: Competence protein M654_003435 ENOG4105RU3 M654_003450 ENOG4105E1Q flagellar hook-associated protein M654_003455 ENOG4105DTJ flagellar hook-associated protein M654_003460 ENOG4105MKD M654_003465 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) M654_003470 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) M654_003475 ENOG4105I03 Flagellin M654_003485 ENOG41083S7 flagellar protein FlaG M654_003490 ENOG4107RT6 flagellar hook-associated M654_003495 ENOG4105MQ3 flagellar protein FliS M654_003510 ENOG4105MS2 ribosomal subunit Interface protein M654_003515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving M654_003535 ENOG4105CAK Cell division ATP-binding protein ftsE M654_003540 ENOG4105CRP Part of the ABC transporter FtsEX involved in M654_003550 ENOG4105DY9 regulatoR M654_003565 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M654_003570 ENOG4105CN1 protease M654_003595 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) M654_003600 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) M654_003615 ENOG4108PY7 M654_003620 ENOG41067S9 phage shock protein C, PspC M654_003625 ENOG41086DT Membrane protein of unknown function M654_003630 ENOG41088CQ domain protein M654_003635 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_003640 ENOG410834F Transcriptional regulator M654_003645 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) M654_003655 ENOG4105HKU nucleoside recognition domain-containing protein M654_003660 ENOG4107XGZ Hydrolase M654_003665 ENOG4108S4C acetyltransferase M654_003670 ENOG4105VRS hydrolase family 18 M654_003680 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) M654_003685 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) M654_003690 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) M654_003695 ENOG4105ECC imidazole-glycerol-phosphate dehydratase M654_003700 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) M654_003705 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase M654_003710 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) M654_003715 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase M654_003730 ENOG4105C3M thioredoxin reductase M654_003735 ENOG4108Z4K mutator MutT protein M654_003740 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) M654_003745 ENOG4105CHW UPF0052 protein M654_003750 ENOG4105CIE May be required for sporulation (By similarity) M654_003755 ENOG4105KRI phosphocarrier protein (HPr M654_003760 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase M654_003765 ENOG4105KVH Transcriptional regulator M654_003770 ENOG4108VA3 3-hexulose-6-phosphate synthase M654_003775 ENOG41080HJ 6-phospho 3-hexuloisomerase M654_003780 ENOG4108ZHR arsR family transcriptional regulator M654_003785 ENOG4108SQ9 flavin reductase domain protein, FMN-binding M654_003790 ENOG4105C5I Dehydrogenase M654_003795 ENOG4108V2W Carbonate dehydratase M654_003800 ENOG4105CHH sulfate transporter M654_003805 ENOG4107TVP HD domain protein M654_003810 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain M654_003815 ENOG4108URH decarboxylase M654_003820 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) M654_003845 ENOG4108HKT sucrose-6-phosphate hydrolase M654_003850 ENOG4105EDQ levansucrase EC 2.4.1.10 M654_003855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M654_003865 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein M654_003875 ENOG4105HTX biosynthesis protein M654_003880 ENOG4108QV3 biosynthesis protein M654_003890 ENOG4108PQP glycosyl transferase group 1 M654_003895 ENOG4105K64 Glycosyl transferase, family 2 M654_003900 ENOG4108KMV Glycosyl transferase (Group 1 M654_003905 ENOG41068W6 Capsular polysaccharide biosynthesis protein M654_003910 ENOG4107QRS glycosyltransferase group 2 family protein M654_003920 ENOG4105K64 Glycosyl transferase, family 2 M654_003930 ENOG4105D3Q Sugar transferase M654_003935 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family M654_003940 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase M654_003945 ENOG4108ZPC Polysaccharide pyruvyl transferase M654_003955 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_003960 ENOG4105DAA L-lactate M654_003965 ENOG4105JXH GntR family transcriptional regulator M654_003970 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) M654_004005 ENOG4108WAV Transcriptional regulator M654_004010 ENOG4105KIS phospholipid-binding protein M654_004035 ENOG4105DEN Luciferase family M654_004050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase M654_004055 ENOG4105BZA Phosphoglycerate kinase M654_004060 ENOG4105CP7 Triose-phosphate isomerase M654_004065 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) M654_004070 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) M654_004075 ENOG4108V4B ThiJ pfpI M654_004085 ENOG4105C8Q Methyl-accepting chemotaxis M654_004090 ENOG4108MES Periplasmic binding protein M654_004095 ENOG4105T65 Membrane-associated protein M654_004105 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein M654_004110 ENOG4107HG4 Transcriptional regulator M654_004115 ENOG4108IJ8 ABC transporter M654_004120 ENOG4105E90 ABC transporter M654_004125 ENOG4108HQR Glycine betaine M654_004130 ENOG4105R40 Glycine betaine carnitine choline M654_004155 ENOG4105XZU Preprotein translocase, subunit SecG M654_004165 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) M654_004170 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) M654_004185 ENOG4107SYN Glycosyl hydrolases family 43 M654_004190 ENOG4108MYR Secreted protein M654_004215 ENOG4105F0F Oxalate decarboxylase M654_004225 ENOG4106DF4 Sigma-70, region 4 M654_004235 ENOG4105C72 UPF0176 protein M654_004250 ENOG4105D9R oxidoreductase M654_004260 ENOG41086NF K02433 aspartyl-tRNA(Asn) glutamyl-tRNA (Gln) amidotransferase subunit A EC 6.3.5.6 6.3.5.7 M654_004275 ENOG4106A3M Cytochrome p-450 M654_004280 ENOG410625E M654_004310 ENOG4105C9F isomerase M654_004315 ENOG4105DET Rhamnulokinase M654_004320 ENOG4105E98 transcriptional regulator DeoR family M654_004325 ENOG4107RKG DJ-1/PfpI family M654_004330 ENOG4105VPX protein, conserved in bacteria M654_004335 ENOG410681U heavy metal transport detoxification protein M654_004340 ENOG4105C59 p-type ATPase M654_004345 ENOG4105DSE periplasmic solute binding protein M654_004350 ENOG4105CC5 ABC transporter M654_004355 ENOG4105DIK (ABC) transporter M654_004365 ENOG4105CJQ hydrolase, family 31 M654_004370 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component M654_004380 ENOG4108JE9 extracellular solute-binding protein family 1 M654_004385 ENOG4105C59 p-type ATPase M654_004390 ENOG4107ZQN disulfide bond M654_004415 ENOG4108MTT Glutamate-rich protein grpB M654_004420 ENOG4105EN6 Membrane M654_004430 ENOG4105EEM helicase M654_004440 ENOG4107EPV Aminotransferase class V M654_004445 ENOG4105EEQ Na H antiporter M654_004450 ENOG4105EVU fructokinase M654_004465 ENOG4107QZ2 Sulfatase M654_004480 ENOG4105D5Q Arginine ornithine antiporter M654_004485 ENOG4105DQ5 transport system permease protein M654_004490 ENOG4105EHG Permease protein M654_004495 ENOG4105E0A ABC, transporter M654_004500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_004510 ENOG4105D2H Uronic isomerase M654_004515 ENOG4105CT4 transporter M654_004520 ENOG4107KJX Transcriptional regulator M654_004525 ENOG4107QZW Altronate oxidoreductase M654_004530 ENOG4105CTX dehydratase M654_004540 ENOG4105C5Q Transcriptional regulator M654_004545 ENOG4108RPX mosc domain containing protein M654_004550 ENOG4105EWI Short-chain dehydrogenase reductase Sdr M654_004555 ENOG4105DRR Transcriptional regulator, GntR family M654_004560 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) M654_004565 ENOG4105EHG Permease protein M654_004570 ENOG4105E0A ABC, transporter M654_004575 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) M654_004580 ENOG4105C0A alcohol dehydrogenase M654_004600 ENOG4105G63 Type III effector Hrp-dependent M654_004605 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) M654_004610 ENOG4105CHR reductase M654_004615 ENOG4108WBT adenosyltransferase M654_004620 ENOG4105NBR Pectinesterase M654_004630 ENOG41087YS Phage shock protein A M654_004645 ENOG4105ENE Histidine kinase M654_004650 ENOG4105WH1 Two component transcriptional regulator luxr family M654_004680 ENOG4105C9Q fumarate hydratase class II M654_004685 ENOG41067SE Tetr family transcriptional regulator M654_004690 ENOG4105F3H Histidine kinase M654_004700 ENOG4105C0H protease M654_004705 ENOG4105HUF DNA protection during starvation protein M654_004710 ENOG4105E1F short-chain dehydrogenase reductase M654_004715 ENOG4105DZ1 carboxypeptidase M654_004730 ENOG4108MES Periplasmic binding protein M654_004735 ENOG4105DQ5 transport system permease protein M654_004740 ENOG4108IHU transport system permease protein M654_004745 ENOG4105E0A ABC, transporter M654_004780 ENOG4105CHU acetyl-coa acetyltransferase M654_004785 ENOG4105C1G acyl-Coa dehydrogenase M654_004790 ENOG41080E8 Transcriptional regulator, Spx MgsR family M654_004795 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) M654_004820 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) M654_004825 ENOG4108UMI ABC transporter, permease M654_004830 ENOG4105D01 (LipO)protein M654_004840 ENOG4105PGM cation diffusion facilitator family transporter M654_004845 ENOG4105C3K feS assembly ATPase SufC M654_004850 ENOG4105JRK feS assembly protein SufD M654_004855 ENOG4105C9B Cysteine desulfurase M654_004860 ENOG4108UNV SUF system FeS assembly protein, NifU family M654_004865 ENOG4105DIW FeS assembly protein SUFB M654_004885 ENOG4107VFR oxidoreductase M654_004900 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine M654_004905 ENOG4105XN3 extracellular solute-binding protein family 1 M654_004910 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component M654_004915 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component M654_004920 ENOG4108KPW sugar kinase M654_004925 ENOG4105FDP GntR family transcriptional regulator M654_004930 ENOG4108K8S endonuclease I M654_004950 ENOG4105G9B Transcriptional regulator M654_004960 ENOG4105C5R Aminotransferase M654_004965 ENOG4105CD3 dihydroorotase M654_004970 ENOG4105W1N transcriptional regulator M654_004975 ENOG4105IIP Membrane M654_004980 ENOG4105I3N Conserved Protein M654_004990 ENOG4107R8B 5'-nucleotidase M654_004995 ENOG4105KZD Domain of unknown function (DUF1805) M654_005000 ENOG4108YTE sporulation protein YunB M654_005005 ENOG4105C8J )-transporter M654_005015 ENOG4105FAA peptidase M23 M654_005020 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) M654_005025 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) M654_005030 ENOG4105MMD transcriptional regulator M654_005040 ENOG4105D4U had-superfamily hydrolase, subfamily iia M654_005055 ENOG4108W5N phosphatidylglycerophosphatase a M654_005065 ENOG4105C5I Dehydrogenase M654_005070 ENOG4105D6E homoserine dehydrogenase M654_005075 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) M654_005080 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) M654_005085 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein M654_005090 ENOG41083MR nifu domain-containing protein M654_005105 ENOG4105PY6 Phenolic acid decarboxylase M654_005145 ENOG4108YX9 iron--sulfur cluster insertion protein erpA M654_005150 ENOG4108YM7 Gcn5-related n-acetyltransferase M654_005165 ENOG4105CAY ferredoxin--nadp reductase M654_005170 ENOG4105CEP NADH dehydrogenase M654_005185 ENOG41069ER domain protein M654_005195 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) M654_005215 ENOG4105DCF alanine dehydrogenase M654_005220 ENOG4108K8K Transcriptional regulator M654_005225 ENOG4105BZG amino acid carrier protein M654_005260 ENOG410904N short-chain dehydrogenase reductase M654_005275 ENOG4105C02 permease M654_005300 ENOG4105DAP Nicotinate phosphoribosyltransferase M654_005305 ENOG4105D58 Diguanylate phosphodiesterase M654_005330 ENOG4105BZU Histidine kinase M654_005340 ENOG4105KA0 thioesterase Superfamily protein M654_005345 ENOG4105KJM monovalent cation h antiporter subunit g M654_005355 ENOG4105SC1 monovalent cation H antiporter subunit E M654_005360 ENOG4108JPZ Monovalent cation H antiporter subunit D M654_005365 ENOG4108ZE9 Monovalent cation H antiporter subunit C M654_005370 ENOG4105HC0 Na H antiporter M654_005375 ENOG4105D65 subunit l M654_005390 ENOG4105DJ4 phosphatidylserine decarboxylase M654_005395 ENOG4107ZTW SNARE associated Golgi M654_005400 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase M654_005405 ENOG4108MRH transcriptional regulatory protein M654_005420 ENOG4105KIR Thiol-disulfide oxidoreductase dcc M654_005425 ENOG4105BZ4 penicillin-binding protein M654_005440 ENOG4105Y38 Kinase-associated protein B M654_005450 ENOG4105C87 Aminotransferase class I and II M654_005465 ENOG4108MUZ hydrolase M654_005470 ENOG4108ZB6 transcriptional regulator AsnC family M654_005475 ENOG4105CHM Aminotransferase M654_005485 ENOG4105WG9 Conserved Protein M654_005490 ENOG4107QW4 alcohol dehydrogenase M654_005495 ENOG4107QYV phosphohexose isomerase M654_005500 ENOG41068WN M654_005510 ENOG410900G Protein of unknown function (DUF421) M654_005520 ENOG4107PBV potassium channel M654_005525 ENOG4107PBV potassium channel M654_005535 ENOG4105C37 (CBS) domain M654_005550 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme M654_005555 ENOG4105EA8 2-Nitropropane dioxygenase M654_005565 ENOG4105C8Q Methyl-accepting chemotaxis M654_005570 ENOG4105C8Q Methyl-accepting chemotaxis M654_005575 ENOG4105C8Q Methyl-accepting chemotaxis M654_005580 ENOG4108Z0Z intracellular protease Pfpi family M654_005585 ENOG4105EE0 oxidoreductase M654_005595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) M654_005625 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) M654_005675 ENOG41065RQ ADP-ribosylation crystallin J1 M654_005685 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M654_005810 ENOG4105C2M dna polymerase I M654_005865 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) M654_005870 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M654_005895 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) M654_005905 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) M654_005980 ENOG4108J9Q DNA ligase M654_006135 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase M654_006185 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily M654_006210 ENOG41090VF Stage v sporulation protein ac M654_006215 ENOG4105CZ3 stage V sporulation protein ad M654_006230 ENOG4108QY0 Membrane M654_006235 ENOG4105H67 Protein of unknown function (DUF421) M654_006240 ENOG41073R8 VanW family M654_006245 ENOG4105JQZ Methyltransferase M654_006255 ENOG4105TRT Transcriptional regulator M654_006265 ENOG4108JB8 alcohol dehydrogenase M654_006270 ENOG4108VNY MOSC domain protein M654_006275 ENOG4106DF1 M654_006285 ENOG4105CZN Potassium uptake protein M654_006295 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) M654_006320 ENOG4105N67 Proton-coupled thiamine transporter YuaJ M654_006325 ENOG4105CMD Transcriptional regulator, GntR family M654_006330 ENOG41067KS pro-sigma K processing M654_006490 ENOG4105CIG ABC transporter M654_006495 ENOG4105DIM ABC transporter M654_006500 ENOG4105KAF membrAne M654_006515 ENOG4105FF2 Type I DHQase M654_006520 ENOG4108N23 SpoOM-related protein M654_006525 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) M654_006530 ENOG4105D7T ABC transporter M654_006535 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein M654_006540 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component M654_006545 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) M654_006550 ENOG4107D63 M654_006555 ENOG4105VZ8 Transcriptional regulator M654_006565 ENOG4105DA5 (ABC) transporter M654_006585 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) M654_006600 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) M654_006610 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) M654_006630 ENOG4105CYN Serine protein kinase M654_006635 ENOG4106AKX UPF0229 protein M654_006640 ENOG4105CW7 secretion protein, HlyD family M654_006645 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_006650 ENOG4105CS1 NAD(P)H quinone oxidoreductase M654_006665 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family M654_006670 ENOG4105CZV ABC transporter M654_006675 ENOG4105CJ1 ABC, transporter M654_006680 ENOG4108TU7 Inherit from COG: (ABC) transporter M654_006685 ENOG4105VEQ Cold shock protein M654_006690 ENOG4107R6U sodium dicarboxylate symporter M654_006725 ENOG4105BZU Histidine kinase M654_006745 ENOG41080HJ 6-phospho 3-hexuloisomerase M654_006750 ENOG4108VA3 3-hexulose-6-phosphate synthase M654_006760 ENOG4105F76 Sarcosine oxidase M654_006765 ENOG4105DVW rieske (2Fe-2S) M654_006770 ENOG4108IJ7 Glycine betaine M654_006795 ENOG4105KVH Transcriptional regulator M654_006800 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase M654_006815 ENOG4108YBP pseudouridine synthase M654_006825 ENOG41080XP Cbs domain M654_006830 ENOG4107YBY Hydrolase M654_006835 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase M654_006840 ENOG4105C5H ABC transporter M654_006855 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator M654_006865 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) M654_006870 ENOG4105C6V Glycerol-3-phosphate dehydrogenase M654_006890 ENOG4105BZU Histidine kinase M654_006895 ENOG4105WH1 Two component transcriptional regulator luxr family M654_006915 ENOG4105KPV Transcriptional regulator M654_006920 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) M654_006925 ENOG4105ED1 spovr family M654_006940 ENOG4105BZN citrate synthase M654_006945 ENOG4105C8J )-transporter M654_006955 ENOG41086D8 Transcriptional regulator M654_006960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_006975 ENOG4105J37 M654_006980 ENOG4108AEY RNA polymerase sigma factor M654_006990 ENOG4105F6E Acyl-transferase M654_007005 ENOG4105KAF membrAne M654_007010 ENOG4105C37 (CBS) domain M654_007020 ENOG4105C37 (CBS) domain M654_007045 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M654_007055 ENOG4105D64 Mechanosensitive ion channel M654_007060 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) M654_007075 ENOG4107VMI polysaccharide deacetylase M654_007080 ENOG4105F0I Aminotransferase M654_007090 ENOG4108N2V aldose 1-epimerase M654_007120 ENOG4105BZ1 (ABC) transporter M654_007125 ENOG4105BZ1 (ABC) transporter M654_007160 ENOG410839P M654_007180 ENOG4106MP8 UPF0754 membrane protein M654_007185 ENOG4105WZB UPF0342 protein M654_007195 ENOG4105D4P Coproporphyrinogen iii oxidase M654_007200 ENOG4105CGU Enoyl-CoA hydratase M654_007220 ENOG4108IUX (ABC) transporter M654_007225 ENOG4105RHA ABC transporter, permease M654_007230 ENOG4107VRP DNA repair exonuclease M654_007235 ENOG4106D4I domain protein M654_007240 ENOG4105EQI Metal Dependent Phosphohydrolase M654_007250 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) M654_007295 ENOG4105NBU tryptophan transport protein M654_007300 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) M654_007305 ENOG4105K59 histidine triad (HIT) protein M654_007335 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation M654_007340 ENOG4105BZ4 penicillin-binding protein M654_007345 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) M654_007350 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) M654_007355 ENOG4105C1Q protoporphyrinogen oxidase M654_007365 ENOG4105ECB domain protein M654_007375 ENOG4105DER m42 family M654_007390 ENOG4106AXD M654_007395 ENOG4108RQ5 Beta-lactamase domain-containing protein M654_007400 ENOG4105DF9 Lipoate-protein, ligase M654_007405 ENOG4105CEY Amp-dependent synthetase and ligase M654_007415 ENOG4108JCI Transcriptional regulator M654_007430 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 M654_007440 ENOG4108UZ3 Transporter M654_007445 ENOG4108HUF Transporter M654_007450 ENOG4105DQ5 transport system permease protein M654_007455 ENOG4108U1V ABC transporter, permease M654_007460 ENOG4107TB6 phosphoglycerate mutase M654_007470 ENOG4107F3J Amp-dependent synthetase and ligase M654_007475 ENOG4107ZYJ bioY protein M654_007480 ENOG4106YBV Methyl-accepting chemotaxis M654_007500 ENOG4105XVF Competence transcription factor M654_007505 ENOG41060YP M654_007520 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin M654_007525 ENOG410780I phosphoprotein phosphatase activity M654_007560 ENOG4108KK1 membrane protein AbrB duplication M654_007575 ENOG4105WEF catalase M654_007580 ENOG4105CEY Amp-dependent synthetase and ligase M654_007585 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) M654_007595 ENOG4105BZU Histidine kinase M654_007600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_007610 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein M654_007615 ENOG4105E0C molybdate abc transporter M654_007625 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation M654_007635 ENOG4105EYH Exonuclease M654_007670 ENOG410751J M654_007690 ENOG4105ERH Fumarylacetoacetate hydrolase M654_007710 ENOG4105CAQ asparagine synthetase M654_007720 ENOG4108YZA Nitrogen regulatory protein pii M654_007725 ENOG4105UQX Mate efflux family protein M654_007730 ENOG4106HBX Transcriptional Regulator AraC Family M654_007750 ENOG4105E1K spore germination protein M654_007755 ENOG4108ZUB Lysine exporter protein (Lyse ygga) M654_007760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_007770 ENOG4105DY8 decarboxylase M654_007795 ENOG4105MA6 gCN5-related N-acetyltransferase M654_007800 ENOG4105CHR reductase M654_007820 ENOG4108VPT UPF0234 protein M654_007825 ENOG4105QNR S1 RNA binding domain protein M654_007840 ENOG4105EPR degv family M654_007845 ENOG4107AYK membrAne M654_007855 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) M654_007860 ENOG41073B9 M654_007865 ENOG4108KP7 hydrolase M654_007870 ENOG4108MXZ Esterase M654_007875 ENOG4105VG1 fes assembly suf system protein M654_007885 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase M654_007890 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) M654_007895 ENOG4105CAS nag kinase M654_007900 ENOG4105C8Y Acetylornithine aminotransferase M654_007905 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain M654_007915 ENOG4105DBV ornithine carbamoyltransferase M654_007920 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) M654_007945 ENOG4107RMD Basic membrane lipoprotein M654_007960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) M654_007965 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) M654_007975 ENOG4105C3U ABC transporter M654_007980 ENOG4108JQ7 (ABC) transporter M654_007995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_008005 ENOG4105C31 Tryptophanyl-tRNA synthetase M654_008015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_008020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_008030 ENOG4108JQ7 (ABC) transporter M654_008040 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) M654_008045 ENOG4108ZCF integral membrane protein M654_008055 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis M654_008080 ENOG4108V9W transcriptional regulatory protein M654_008085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism M654_008095 ENOG4105DPN Oligoendopeptidase f M654_008100 ENOG4105T58 Dithiol-disulfide isomerase M654_008105 ENOG4108Z18 K06886 hemoglobin M654_008110 ENOG4105E4C Lytic transglycosylase catalytic M654_008115 ENOG4105MIX Adenylate cyclase M654_008120 ENOG4106EFP UPF0738 protein M654_008130 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) M654_008135 ENOG4105EMS pseudouridine synthase M654_008140 ENOG4107S1Q Phosphatase M654_008150 ENOG4105ETU transcriptional activator (TenA M654_008155 ENOG4108VEU Thiamine monophosphate synthase M654_008170 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) M654_008175 ENOG4105D06 uba thif-type nad fad binding protein M654_008180 ENOG4105DWF phosphomethylpyrimidine kinase M654_008185 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH M654_008190 ENOG4107A88 M654_008240 ENOG4105ENA helicase M654_008250 ENOG4107T5V SNARE associated Golgi M654_008255 ENOG4105CMR udp-glucose 4-epimerase M654_008260 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M654_008275 ENOG4108ZMI UPF0477 protein M654_008300 ENOG4105C28 cystathionine M654_008305 ENOG4105C28 cystathionine M654_008310 ENOG4105JHY Membrane M654_008330 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase M654_008345 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein M654_008360 ENOG4107QRS glycosyltransferase group 2 family protein M654_008365 ENOG4105D5D udp-galactopyranose mutase M654_008370 ENOG4105DKQ ROK family M654_008495 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) M654_008515 ENOG4105VZ8 Transcriptional regulator M654_008585 ENOG4105CDU Replicative dna helicase M654_008600 ENOG4105QBX endodeoxyribonuclease RusA M654_008635 ENOG4107JM4 Tetratricopeptide repeat M654_008640 ENOG4107EV6 Inherit from COG: YD repeat protein M654_008675 ENOG4105IG6 Phage terminase, large subunit M654_008685 ENOG4106CGH Phage Mu protein F like protein M654_008720 ENOG41060SN M654_008735 ENOG4105PQS phage protein M654_008740 ENOG4105FR7 XkdM protein, phage-like element PBSX M654_008745 ENOG4105MTC XkdN-like protein M654_008755 ENOG4108FKH Transglycosylase SLT domain M654_008755 ENOG4108FKH Transglycosylase SLT domain M654_008760 ENOG4108WZM domain protein M654_008765 ENOG4105X7F M654_008775 ENOG4105MFU Protein of unknown function (DUF2634) M654_008780 ENOG41066EA baseplate J family protein M654_008785 ENOG410906S phage-like element pbsx protein xkdt M654_008850 ENOG4108UW5 maltose o-acetyltransferase M654_008860 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) M654_008865 ENOG4105CIB oxidoreductase Domain protein M654_008870 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) M654_008875 ENOG4105DUM transcriptional regulator, lysR family M654_008880 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) M654_008885 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) M654_008895 ENOG4108Q5Y Membrane M654_008900 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase M654_008910 ENOG41069ER domain protein M654_008920 ENOG4105J7D transcriptional regulator M654_008930 ENOG4105K7W phage-related replication protein M654_008935 ENOG410635T phage-like element pbsx protein M654_008980 ENOG4108TFU terminase (Small subunit) M654_008985 ENOG4105IG6 Phage terminase, large subunit M654_008990 ENOG4108MDF Phage Portal Protein M654_009020 ENOG41060SN M654_009035 ENOG4105PQS phage protein M654_009040 ENOG4105FR7 XkdM protein, phage-like element PBSX M654_009045 ENOG4105MTC XkdN-like protein M654_009055 ENOG4108FKH Transglycosylase SLT domain M654_009055 ENOG4108FKH Transglycosylase SLT domain M654_009060 ENOG4108WZM domain protein M654_009065 ENOG4105X7F M654_009075 ENOG4105MFU Protein of unknown function (DUF2634) M654_009080 ENOG41066EA baseplate J family protein M654_009085 ENOG410906S phage-like element pbsx protein xkdt M654_009095 ENOG41068G1 M654_009100 ENOG41068G1 M654_009105 ENOG4107VXM glycerophosphoryl diester phosphodiesterase M654_009110 ENOG41068G1 M654_009130 ENOG4107XBN GntR Family Transcriptional Regulator M654_009135 ENOG4105CPQ Dehydrogenase M654_009140 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) M654_009145 ENOG4105DMW Dehydrogenase reductase M654_009150 ENOG4105CPQ Dehydrogenase M654_009155 ENOG4108I5G Major Facilitator superfamily M654_009175 ENOG4105CJ3 phosphate transporter M654_009180 ENOG4107GRR phosphate transport regulator M654_009185 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) M654_009195 ENOG4105C2F Histidine kinase M654_009200 ENOG4105EQD regulatoR M654_009205 ENOG410769Z extracellular solute-binding protein family 1 M654_009210 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M654_009215 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M654_009220 ENOG4105F5H Glycosyl Hydrolase Family 88 M654_009225 ENOG41075H3 AraC family transcriptional regulator M654_009230 ENOG4107TDE lipolytic protein G-D-S-L family M654_009245 ENOG4105CX8 fg-gap repeat protein M654_009250 ENOG4107TDE lipolytic protein G-D-S-L family M654_009255 ENOG4105CX8 fg-gap repeat protein M654_009265 ENOG4107TDE lipolytic protein G-D-S-L family M654_009275 ENOG4105EKC M654_009280 ENOG4105E0S extracellular solute-binding protein family 1 M654_009290 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component M654_009295 ENOG4107R7I amino acid M654_009305 ENOG4105C0H protease M654_009355 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase M654_009375 ENOG4108ME1 Peptidase M55 D-aminopeptidase M654_009380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_009385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_009390 ENOG4105C3U ABC transporter M654_009400 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A M654_009405 ENOG4105DTQ mandelate racemase muconate lactonizing M654_009410 ENOG4107SN7 NLP P60 protein M654_009415 ENOG4108JQ7 (ABC) transporter M654_009425 ENOG4107TUM Amidinotransferase M654_009430 ENOG4108S4H thioesterase Superfamily protein M654_009435 ENOG4108J20 pectate lyase M654_009455 ENOG410839T multidrug resistance protein M654_009460 ENOG41080TC multidrug resistance protein M654_009465 ENOG4105CIY formyltetrahydrofolate deformylase M654_009470 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) M654_009475 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) M654_009485 ENOG4105K56 Transcriptional regulator M654_009490 ENOG4108ZHJ Organic hydroperoxide resistance protein M654_009500 ENOG4107Y2X deaminase M654_009505 ENOG4105CVJ phosphoglycerate mutase M654_009520 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) M654_009525 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin M654_009535 ENOG4105CJW magnesium transporter M654_009545 ENOG4105V75 Transcriptional regulator M654_009560 ENOG4105DQE DNA ligase M654_009565 ENOG4105FDF Could be involved in DNA repair (By similarity) M654_009570 ENOG4105BZU Histidine kinase M654_009575 ENOG4107T5V SNARE associated Golgi M654_009580 ENOG4107TS3 membrane protein, TerC M654_009585 ENOG4108WZW RNA polymerase sigma M654_009595 ENOG410681C small acid-soluble spore protein M654_009605 ENOG4105D0M Protease HtpX homolog M654_009615 ENOG4107RVG penicillin-binding protein M654_009625 ENOG4108TGC Acyltransferase M654_009630 ENOG4105BZU Histidine kinase M654_009635 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M654_009640 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) M654_009650 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase M654_009660 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate M654_009675 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) M654_009680 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) M654_009700 ENOG41090MY MarR family Transcriptional regulator M654_009705 ENOG4105ER2 Ompa motb domain protein M654_009710 ENOG4105E14 MotA TolQ exbB proton channel M654_009720 ENOG4108K88 Membrane M654_009725 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) M654_009730 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase M654_009735 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) M654_009740 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) M654_009785 ENOG4105NX3 Membrane M654_009790 ENOG4105VMP Transcriptional regulator M654_009830 ENOG4105F0V Cell wall hydrolase M654_009845 ENOG4105C59 p-type ATPase M654_009850 ENOG4105DC7 peptidase M24 M654_009865 ENOG4105CID antiterminator M654_009875 ENOG4105KRI phosphocarrier protein (HPr M654_009880 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) M654_009890 ENOG4105F6S Spore photoproduct lyase M654_009900 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer M654_009905 ENOG4105CHR reductase M654_009910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase M654_009915 ENOG4105K4I Scp-like extracellular M654_009925 ENOG4105BZU Histidine kinase M654_009930 ENOG4105CHM Aminotransferase M654_009940 ENOG41085PJ rdd domain containing protein M654_009950 ENOG4107R88 Chemotaxis protein (CheV) M654_009955 ENOG4105UIN M654_009965 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein M654_009975 ENOG4105K6S Short-chain dehydrogenase reductase Sdr M654_009980 ENOG4105EPM Diguanylate phosphodiesterase M654_009985 ENOG4107IN1 Protein of unknown function (DUF1797) M654_009990 ENOG4108XRC Protein of unknown function (DUF458) M654_010020 ENOG4105NQC Flavodoxin M654_010025 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) M654_010040 ENOG4105D3R alkyl hydroperoxide reductase M654_010045 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M654_010060 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) M654_010065 ENOG4105D06 uba thif-type nad fad binding protein M654_010070 ENOG4105CVM Molybdenum cofactor synthesis domain protein M654_010075 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein M654_010080 ENOG4108ZAF Molybdopterin M654_010085 ENOG41067WU Molybdopterin converting factor (Subunit 1) M654_010095 ENOG4105BZ1 (ABC) transporter M654_010100 ENOG4105BZ1 (ABC) transporter M654_010110 ENOG4107X8C Efflux transporter RND family MFP subunit M654_010115 ENOG4105C19 ABC transporter M654_010120 ENOG4107RBB ABC transporter, permease M654_010130 ENOG4105E98 transcriptional regulator DeoR family M654_010135 ENOG4105DE4 1-phosphofructokinase M654_010140 ENOG4105DM4 PTS System M654_010145 ENOG4105C3F Signal peptidase i M654_010155 ENOG4105C5H ABC transporter M654_010185 ENOG4105BZU Histidine kinase M654_010190 ENOG4107ZYR domain protein M654_010200 ENOG4105CN5 Metallo-Beta-Lactamase M654_010210 ENOG4108X4Q Hydrolase M654_010215 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) M654_010235 ENOG4105CPP Dehydrogenase, E1 component M654_010240 ENOG4105C7S Dehydrogenase M654_010245 ENOG4107QN2 dihydrolipoyl dehydrogenase M654_010260 ENOG4105CXN decarboxylase M654_010265 ENOG4105WBI UPF0223 protein M654_010280 ENOG4105ECY inositol monophosphatase M654_010305 ENOG4105EAA nucleoside M654_010315 ENOG4105CI3 gtp-binding protein typa M654_010320 ENOG4105QA2 M654_010325 ENOG4108INS Transcriptional regulator M654_010330 ENOG4107SCK Monooxygenase M654_010345 ENOG4108IAB Phoh family M654_010355 ENOG4105CSV Glutaminase M654_010360 ENOG4105ZPI UPF0358 protein M654_010365 ENOG4105CNI cell division protein FtsW M654_010370 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) M654_010380 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) M654_010390 ENOG4105BZ9 Cytochrome C oxidase, subunit I M654_010395 ENOG4105CCU oxidase (Subunit III) M654_010400 ENOG41064X9 cytochrome C oxidase subunit IV M654_010415 ENOG41080XQ Signal transduction protein with cbs domains M654_010420 ENOG4106UY4 Inherit from COG: Scp-like extracellular M654_010445 ENOG4106H78 methyltransferase M654_010450 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) M654_010455 ENOG4105H20 Sporulation integral membrane protein YlbJ M654_010460 ENOG41063PX domain protein M654_010465 ENOG4105CDE UPF0348 protein M654_010470 ENOG4105KNH Nucleic acid-binding protein M654_010475 ENOG41067VY 50S ribosomal protein L32 M654_010495 ENOG41074B2 UPF0747 protein M654_010500 ENOG4108V6E Cell division protein mraZ M654_010505 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) M654_010515 ENOG4105CJN penicillin-binding protein M654_010520 ENOG4105CJN penicillin-binding protein M654_010525 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) M654_010530 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) M654_010535 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) M654_010540 ENOG4105CNI cell division protein FtsW M654_010545 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) M654_010550 ENOG4105D4A Cell wall formation (By similarity) M654_010555 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) M654_010560 ENOG4108R2U division initiation protein M654_010570 ENOG4105K67 small basic protein M654_010575 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) M654_010580 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) M654_010595 ENOG4105FFI sigma-e processing peptidase spoiiga M654_010600 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_010610 ENOG4105DKW ABC transporter M654_010615 ENOG4105DHI Methyltransferase M654_010620 ENOG4105WR5 sporulation protein, YlmC YmxH family M654_010625 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase M654_010630 ENOG4105DFA alanine racemase domain protein M654_010635 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) M654_010640 ENOG41067XK integral membrane protein M654_010645 ENOG4105DBK s4 domain protein M654_010665 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) M654_010670 ENOG4105C34 Pseudouridine synthase M654_010675 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) M654_010685 ENOG4105CXT aspartate transcarbamylase M654_010690 ENOG4105CD3 dihydroorotase M654_010695 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain M654_010700 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain M654_010705 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) M654_010710 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) M654_010715 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) M654_010730 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) M654_010750 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) M654_010755 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein M654_010760 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein M654_010775 ENOG4105DSJ YicC domain protein M654_010780 ENOG4105KC4 UPF0296 protein M654_010785 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) M654_010790 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) M654_010795 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase M654_010800 ENOG4105C25 Primosomal protein n' M654_010805 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) M654_010810 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) M654_010815 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B M654_010820 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs M654_010825 ENOG4108ZF3 Phosphatase M654_010830 ENOG4105D9P serine threonine protein kinase M654_010835 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) M654_010840 ENOG4105DJV ribulose-phosphate 3-epimerase M654_010845 ENOG4105FJ0 thiamine M654_010855 ENOG4105VB9 50S ribosomal protein l28 M654_010860 ENOG4108ZAA Alkaline-shock protein M654_010865 ENOG4105DP4 dak2 domain fusion protein ylov M654_010875 ENOG4105EJQ L-serine dehydratase M654_010880 ENOG4105CB5 ATP-dependent DNA helicase recG M654_010885 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) M654_010890 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) M654_010895 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase M654_010900 ENOG4105CHR reductase M654_010905 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) M654_010910 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) M654_010915 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) M654_010920 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) M654_010925 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) M654_010935 ENOG4105K5M 30s ribosomal protein S16 M654_010940 ENOG4108BW8 UPF0109 protein M654_010950 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) M654_010955 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) M654_010960 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) M654_010965 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) M654_010970 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) M654_010980 ENOG4105VM1 flagellar M654_010985 ENOG4105CMV Succinyl-CoA synthetase subunit beta M654_010990 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha M654_010995 ENOG4105C79 DNA protecting protein DprA M654_011000 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) M654_011005 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) M654_011010 ENOG4108HE4 integrase family M654_011015 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) M654_011020 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) M654_011025 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) M654_011030 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) M654_011035 ENOG4108ZC9 flagellar basal-body rod protein flgc M654_011040 ENOG4105VQ0 flagellar hook-basal body complex protein fliE M654_011045 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) M654_011050 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M654_011065 ENOG4106YF4 Flagellar biosynthesis chaperone M654_011075 ENOG410696Y Flagellar hook-length control protein M654_011080 ENOG410822I Flagellar hook capping protein M654_011085 ENOG4108JQA flagellar M654_011090 ENOG41068WV flagellar FlbD family protein M654_011100 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) M654_011105 ENOG4105DD5 Flagellar motor switch protein M654_011110 ENOG4107YTP response regulator receiver protein M654_011120 ENOG4105CN7 Flagellar biosynthetic protein FliP M654_011125 ENOG4105VS8 Flagellar biosynthetic protein fliq M654_011130 ENOG4105D19 Role in flagellar biosynthesis (By similarity) M654_011135 ENOG4105D00 flagellar biosynthetic protein flhB M654_011140 ENOG4105D7B Flagellar biosynthesis protein flha M654_011145 ENOG4105FZW flagellar biosynthesis regulator FlhF M654_011155 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) M654_011160 ENOG4105CBS Chea signal transduction histidine kinase M654_011165 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis M654_011175 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) M654_011180 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_011190 ENOG4105CE9 30S ribosomal protein S2 M654_011195 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) M654_011205 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) M654_011210 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) M654_011215 ENOG4105KNE Phosphatidate cytidylyltransferase M654_011225 ENOG4105DZP Membrane-associated zinc metalloprotease M654_011235 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) M654_011245 ENOG4105CYP glycoside hydrolase, family M654_011255 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) M654_011260 ENOG4105CHV Transcription elongation factor NusA M654_011265 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination M654_011270 ENOG4105VHM ribosomal protein M654_011275 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) M654_011280 ENOG4105W7A Protein of unknown function (DUF503) M654_011285 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) M654_011290 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) M654_011295 ENOG4105DTN riboflavin biosynthesis protein ribF M654_011300 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) M654_011305 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) M654_011315 ENOG4105C1V Peptidase, M16 M654_011325 ENOG4105E35 Dipicolinate synthase subunit A M654_011330 ENOG4108S0H Dipicolinic acid synthetase, b subunit M654_011335 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) M654_011345 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) M654_011355 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit M654_011365 ENOG4105CNU cell division protein FtsK M654_011370 ENOG4105FDP GntR family transcriptional regulator M654_011390 ENOG4108RKS Short-chain dehydrogenase reductase Sdr M654_011395 ENOG4105XZV Protein of unknown function (DUF3243) M654_011410 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase M654_011415 ENOG4105CEV competence damage-inducible protein M654_011420 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) M654_011430 ENOG4105D48 metallophosphoesterase M654_011435 ENOG4105MCT stage V sporulation protein S M654_011440 ENOG4108IGT Dipeptidase M654_011445 ENOG4105CPQ Dehydrogenase M654_011450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) M654_011455 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) M654_011470 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) M654_011475 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) M654_011490 ENOG4108NHD germination protein M654_011550 ENOG41067QW Transcriptional regulator M654_011570 ENOG4105K7K Transcriptional regulator M654_011595 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein M654_011600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_011605 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_011610 ENOG4108RZA ABC transporter M654_011615 ENOG4108S9F abc transporter, atp-binding protein M654_011630 ENOG4105I1F Resistance protein M654_011640 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M654_011665 ENOG4108IBT Inherit from COG: transposase M654_011670 ENOG4105EAH synthase M654_011685 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) M654_011695 ENOG4105XPP Protein of unknown function (DUF1275) M654_011705 ENOG4105U6C Alpha beta hydrolase fold protein M654_011720 ENOG41080BT SNARE associated Golgi M654_011725 ENOG4105FQP Beta-lactamase M654_011730 ENOG41087PP glycosyltransferase MGT family M654_011735 ENOG4107QTZ amino acid M654_011750 ENOG4105VRS hydrolase family 18 M654_011765 ENOG4108X3M OsmC Ohr family protein M654_011770 ENOG4107E54 Small Multidrug Resistance protein M654_011795 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) M654_011800 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) M654_011810 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) M654_011815 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M654_011820 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M654_011825 ENOG4105U6W MutT NUDIX family protein M654_011830 ENOG4105DRR Transcriptional regulator, GntR family M654_011850 ENOG4105K59 histidine triad (HIT) protein M654_011860 ENOG4106BHF M654_011885 ENOG4106BHF M654_011890 ENOG4106ANW SMI1_KNR4 M654_011925 ENOG4108YZ9 Urea amidohydrolase subunit gamma M654_011930 ENOG4105KI2 Urea amidohydrolase subunit beta M654_011940 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) M654_011945 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) M654_011950 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) M654_011955 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) M654_011965 ENOG4105U3E Transcriptional regulator M654_011975 ENOG4106F1P AAA ATPase, central domain protein M654_011980 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) M654_011985 ENOG4105CXI aluminum resistance protein M654_011990 ENOG4105KV4 Transcriptional regulator M654_011995 ENOG4105C5F glutamine synthetase M654_012130 ENOG4105CAR Terminase, large subunit M654_012200 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase M654_012240 ENOG4107EV6 Inherit from COG: YD repeat protein M654_012295 ENOG4105ETZ PTS System M654_012300 ENOG4105F3R pts system mannose fructose sorbose family iid M654_012310 ENOG410635A Membrane M654_012340 ENOG4105CAT Cytidine monophosphate kinase M654_012360 ENOG4105GIG M654_012380 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) M654_012420 ENOG4108MK9 spermidine N(1)-acetyltransferase M654_012445 ENOG4105WQG acetyltransferase M654_012455 ENOG41062JF Transcriptional regulator M654_012475 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) M654_012490 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) M654_012500 ENOG4108SVB resolvase M654_012505 ENOG4105VPS UPF0291 protein M654_012510 ENOG4105CV1 Transketolase (EC 2.2.1.1) M654_012520 ENOG4105VXM UPF0154 protein M654_012530 ENOG4107QIV Cytochrome c biogenesis protein M654_012555 ENOG41076DU acid-soluble spore protein P M654_012565 ENOG4108I0Z Aconitate hydratase M654_012585 ENOG41067CD Small, acid-soluble spore protein Tlp M654_012595 ENOG4105MI2 M654_012600 ENOG4105W8X HesB YadR YfhF-family protein M654_012605 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) M654_012610 ENOG4105K4P CoA-binding domain protein M654_012615 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M654_012625 ENOG4105CHR reductase M654_012650 ENOG4105R3A Nitrate reductase M654_012655 ENOG4108IUE nitrate reductase beta subunit M654_012690 ENOG4107V6Q Cyclic nucleotide-binding domain M654_012710 ENOG4105DSQ Nitric oxide reductase M654_012715 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) M654_012720 ENOG4106U2H Protein of unknown function (DUF1360) M654_012725 ENOG4107QWR cellulase (EC 3.2.1.4) M654_012735 ENOG4108428 Inherit from COG: -acetyltransferase M654_012745 ENOG4105F27 Major Facilitator M654_012755 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M654_012770 ENOG4108M26 parallel beta-helix repeat protein M654_012800 ENOG41060WC Enoyl-CoA hydratase M654_012805 ENOG4105C26 Dehydrogenase M654_012810 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase M654_012815 ENOG4105C1G acyl-Coa dehydrogenase M654_012820 ENOG4105DG6 mannose-6-phosphate isomerase M654_012825 ENOG4105DM4 PTS System M654_012845 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family M654_012855 ENOG4108JGH Tetr family transcriptional regulator M654_012880 ENOG4105DSG hydrolase family 43 M654_012890 ENOG4105K63 Thioredoxin M654_012900 ENOG4105BZ1 (ABC) transporter M654_012905 ENOG4105BZ1 (ABC) transporter M654_012915 ENOG4105C28 cystathionine M654_012930 ENOG4106KE4 Dehydrogenase M654_012940 ENOG4108UXE Protein tyrosine phosphatase M654_012945 ENOG4107R5R arsenical pump membrane protein M654_012950 ENOG41082YX Transcriptional regulator, arsr family M654_012955 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M654_012965 ENOG4105CSC Glucose uptake protein M654_012970 ENOG4105F32 YngK protein M654_012980 ENOG4105F1A Pyruvate formate-lyase M654_012990 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) M654_012995 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family M654_013000 ENOG4105D3P Mannan endo-1,4-beta-mannosidase M654_013010 ENOG4105ETE Transcriptional regulator (LacI family M654_013015 ENOG4105CS2 ec 3.2.1.21 M654_013025 ENOG4107FKK extracellular solute-binding protein family 1 M654_013030 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component M654_013035 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component M654_013045 ENOG41066F8 ROK family M654_013095 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) M654_013100 ENOG4107QX3 carboxylase M654_013105 ENOG4105E39 Enoyl-CoA hydratase M654_013110 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase M654_013115 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit M654_013120 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase M654_013125 ENOG4105CEY Amp-dependent synthetase and ligase M654_013130 ENOG4105C1G acyl-Coa dehydrogenase M654_013135 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) M654_013140 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) M654_013150 ENOG4105H67 Protein of unknown function (DUF421) M654_013155 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) M654_013160 ENOG4107RIQ Sulfate adenylate transferase M654_013170 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) M654_013175 ENOG41061P3 phosphosulfolactate synthase M654_013185 ENOG4105DIA mandelate racemase muconate lactonizing M654_013190 ENOG4107RCC Major Facilitator Superfamily M654_013210 ENOG4105BZ8 glutamate synthase M654_013215 ENOG4105CBC glutamate synthase M654_013220 ENOG4105C5Q Transcriptional regulator M654_013250 ENOG4105BZ1 (ABC) transporter M654_013255 ENOG4105DGI Alkaline phosphatase M654_013270 ENOG4105C0R drug resistance transporter emrb qaca subfamily M654_013275 ENOG4108J2R molybdopterin oxidoreductase M654_013290 ENOG4108Q8B Spore germination protein M654_013295 ENOG4108NHD germination protein M654_013300 ENOG4108Q8B Spore germination protein M654_013305 ENOG4108Q8B Spore germination protein M654_013320 ENOG4108NHD germination protein M654_013330 ENOG4105E1K spore germination protein M654_013345 ENOG4105C8Q Methyl-accepting chemotaxis M654_013350 ENOG4108Z7R Chaperone CsaA M654_013355 ENOG4105KNA -acetyltransferase M654_013360 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin M654_013370 ENOG4108RZE Tetr family transcriptional regulator M654_013380 ENOG4105T9C HD domain M654_013390 ENOG4105FVX M654_013410 ENOG4108W8B Beta-lactamase domain protein M654_013420 ENOG4105D29 Helix-turn-helix type 11 domain protein M654_013430 ENOG4105KTU Transcriptional regulator, arsr family M654_013445 ENOG4105CUB amino acid M654_013455 ENOG4105C5E polysaccharide biosynthesis protein M654_013470 ENOG4107T8Q Glycosyl transferase (Group 1 M654_013475 ENOG4108SJC Membrane M654_013495 ENOG4107RUZ Sss sodium solute transporter superfamily M654_013500 ENOG41069ER domain protein M654_013505 ENOG4105C9U ATP-dependent DNA helicase RecQ M654_013580 ENOG4108ZMX Domain of unknown function (DU1801) M654_013585 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase M654_013590 ENOG4105NPE arsR family transcriptional regulator M654_013630 ENOG4108NHD germination protein M654_013655 ENOG4105DXI Major Facilitator superfamily M654_013660 ENOG4107S9D Alpha beta hydrolase M654_013675 ENOG410829K Lysine exporter protein (Lyse ygga) M654_013680 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) M654_013685 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M654_013730 ENOG4105SF0 DinB family M654_013735 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) M654_013740 ENOG4105SCY DNAK suppressor M654_013755 ENOG4105C26 Dehydrogenase M654_013765 ENOG4105CGD Nad-dependent epimerase dehydratase M654_013775 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) M654_013785 ENOG4105CPC Aldo Keto reductase M654_013790 ENOG4105EWU Squalene--hopene cyclase M654_013795 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M654_013810 ENOG4105C8J )-transporter M654_013815 ENOG4105C09 Bile acid M654_013820 ENOG4105C7S Dehydrogenase M654_013825 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 M654_013830 ENOG4107T89 von Willebrand factor, type A M654_013835 ENOG4105GMT ATPase associated with various cellular activities aaa_5 M654_013845 ENOG4105K4H Nlp p60 protein M654_013870 ENOG4105FR1 rard protein M654_013880 ENOG4108YQE rare lipoprotein a M654_013905 ENOG4105FBA Phospholipase Carboxylesterase M654_013920 ENOG4105E1V na solute symporter M654_013940 ENOG4108VXD carboxy-peptidase M654_013945 ENOG4105D3A purine nucleoside phosphorylase DeoD-type M654_013950 ENOG4108PJD permease M654_013965 ENOG4106Z5R M654_013970 ENOG410841Q phosphoesterase PA-phosphatase related protein M654_013985 ENOG4105VSD UPF0346 protein M654_013995 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein M654_014000 ENOG4108TSC N-acetyltransferase M654_014005 ENOG4107S4Y M20 DapE family protein YgeY M654_014020 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) M654_014040 ENOG4105E0X reductase M654_014075 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) M654_014080 ENOG41090WU lipolytic protein G-D-S-L family M654_014085 ENOG4108KF3 Electron transport protein SCO1 SenC M654_014100 ENOG4105C7B Threonine dehydratase M654_014110 ENOG4108UT2 hemolysin iii M654_014120 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) M654_014135 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) M654_014140 ENOG4107YX5 Pfam:DUF548 M654_014150 ENOG4105C01 Dihydroxy-acid dehydratase M654_014165 ENOG4108V06 Glutathione peroxidase M654_014170 ENOG4105CKU formyltetrahydrofolate synthetase M654_014175 ENOG4105CVG Homoserine O-transsuccinylase M654_014180 ENOG4108QBV Monogalactosyldiacylglycerol synthase M654_014220 ENOG41081VK Ribonuclease M654_014240 ENOG410890F Dynamin family M654_014255 ENOG41065KQ synthase M654_014265 ENOG4105C2W permease M654_014270 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) M654_014275 ENOG4105CTD carboxy-peptidase M654_014280 ENOG4105DVT helicase M654_014290 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) M654_014300 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) M654_014305 ENOG4108UKS UPF0398 protein M654_014315 ENOG4107X2U Inherit from COG: Exonuclease-like protein M654_014320 ENOG4108I5C dEAD DEAH box helicase M654_014370 ENOG4105BZ4 penicillin-binding protein M654_014380 ENOG4105CSM endonuclease III M654_014395 ENOG4105CHM Aminotransferase M654_014405 ENOG4105YAC M654_014410 ENOG4105DVT helicase M654_014415 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) M654_014420 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) M654_014425 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) M654_014435 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate M654_014440 ENOG4105CPK Glycosyl transferase (Group 1 M654_014445 ENOG4105FJR Lmbe family M654_014450 ENOG4108Z5K methylglyoxal synthase M654_014455 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) M654_014460 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase M654_014465 ENOG4108JYZ YitT family M654_014485 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) M654_014500 ENOG4108SXZ UPF0302 protein M654_014505 ENOG41068YB TPR repeat-containing protein M654_014520 ENOG4105CIH Imidazole acetol-phosphate transaminase M654_014525 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) M654_014530 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) M654_014540 ENOG4105DK0 Indole-3-glycerol phosphate synthase M654_014545 ENOG4108I0Q anthranilate phosphoribosyltransferase M654_014550 ENOG4105CRQ synthase (Component I) M654_014555 ENOG4105KHN chorismate mutase M654_014560 ENOG4105D49 3-dehydroquinate synthase M654_014565 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase M654_014570 ENOG4105BZU Histidine kinase M654_014575 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) M654_014580 ENOG4105EAH synthase M654_014585 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) M654_014590 ENOG4105XXQ heptaprenyl diphosphate synthase component I M654_014600 ENOG4105EUJ GTP cyclohydrolase i M654_014605 ENOG4105K70 DNA-binding protein M654_014610 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) M654_014625 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase M654_014630 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) M654_014635 ENOG41065D1 M654_014640 ENOG4105S2F M654_014655 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) M654_014660 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) M654_014665 ENOG4105CAT Cytidine monophosphate kinase M654_014675 ENOG4105MSI germination protein ypeb M654_014690 ENOG4105HDK L-asparaginase M654_014695 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase M654_014710 ENOG4107RGJ metallophosphoesterase M654_014725 ENOG4105I7S Abortive infection protein M654_014730 ENOG4105C9U ATP-dependent DNA helicase RecQ M654_014735 ENOG4105T7X M654_014745 ENOG4108SAX Membrane M654_014750 ENOG4108JQ1 Dehydrogenase M654_014755 ENOG4105DR5 peptidase M654_014785 ENOG4105US7 Histidine kinase M654_014790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_014795 ENOG4105BZU Histidine kinase M654_014800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_014805 ENOG4105CRE cytochrome C M654_014810 ENOG4107TWT Cytochrome c biogenesis protein M654_014815 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M654_014820 ENOG4105FE9 pseudouridine synthase M654_014830 ENOG4108JIC nucleoside recognition domain protein M654_014835 ENOG4105DZ1 carboxypeptidase M654_014845 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) M654_014850 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) M654_014870 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) M654_014875 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) M654_014880 ENOG4108R6K riboflavin synthase, subunit alpha M654_014885 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) M654_014900 ENOG4107ZE5 PPIases accelerate the folding of proteins M654_014910 ENOG4105PTM secreted protein M654_014915 ENOG4105K7W phage-related replication protein M654_014920 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) M654_014935 ENOG4105G6R Stage v sporulation protein ae M654_014945 ENOG4105CZ3 stage V sporulation protein ad M654_014950 ENOG41090VF Stage v sporulation protein ac M654_014965 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_014970 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) M654_014975 ENOG41082AN stage II sporulation protein M654_014980 ENOG4105DZ1 carboxypeptidase M654_014990 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) M654_014995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) M654_015005 ENOG4105I3K Ferric uptake regulator, Fur family M654_015010 ENOG4105MZ9 stage II sporulation protein m M654_015015 ENOG4105CK1 PTS System M654_015020 ENOG4105VZJ PTS System M654_015025 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease M654_015050 ENOG4107YB6 acetyltransferase, (GNAT) family M654_015060 ENOG4108YZ4 nudix hydrolase M654_015070 ENOG4105PF9 Transcriptional regulator M654_015080 ENOG4105CPC Aldo Keto reductase M654_015100 ENOG4106HZJ M654_015110 ENOG4105RHY Pfam:UPF0157 M654_015115 ENOG4105KAC Antibiotic biosynthesis monooxygenase M654_015120 ENOG4108XET gCN5-related N-acetyltransferase M654_015125 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold M654_015135 ENOG4107RRN ABC transporter substrate-binding protein M654_015140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_015145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_015150 ENOG4108RZA ABC transporter M654_015160 ENOG4107R73 Mate efflux family protein M654_015175 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) M654_015190 ENOG4105E5W Transporter M654_015195 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase M654_015210 ENOG4105CDA abc transporter atp-binding protein M654_015235 ENOG4105BZU Histidine kinase M654_015240 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_015250 ENOG4105K7W phage-related replication protein M654_015255 ENOG4108IXY short-chain dehydrogenase reductase M654_015260 ENOG41069FQ Metallo-beta-lactamase superfamily M654_015265 ENOG4105II7 pyrroline-5-carboxylate reductase M654_015275 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase M654_015285 ENOG4105WDJ 50S ribosomal protein L33 M654_015290 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) M654_015295 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase M654_015310 ENOG4105H1G trap transporter solute receptor taxi family M654_015315 ENOG4105CIF Ornithine Cyclodeaminase M654_015330 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) M654_015350 ENOG4108TZY GntR Family Transcriptional Regulator M654_015355 ENOG4105CS2 ec 3.2.1.21 M654_015360 ENOG4105CK1 PTS System M654_015365 ENOG4105VCP PTS System M654_015370 ENOG4105VZJ PTS System M654_015375 ENOG4105G6Z alkaline phosphatase M654_015380 ENOG4105H9W Short-chain dehydrogenase reductase Sdr M654_015385 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) M654_015390 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) M654_015400 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) M654_015405 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) M654_015410 ENOG4108HNZ carboxyl transferase M654_015420 ENOG4108QEG Membrane M654_015425 ENOG4105CDA abc transporter atp-binding protein M654_015430 ENOG4105E5Q amino acid AbC transporter M654_015435 ENOG4108HW3 (ABC) transporter M654_015440 ENOG4108Y6J UPF0403 protein M654_015445 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) M654_015450 ENOG4105C7S Dehydrogenase M654_015455 ENOG4105CPP Dehydrogenase, E1 component M654_015470 ENOG4105CKM Branched-chain carboxylic acid kinase M654_015475 ENOG4107RDP Dehydrogenase M654_015485 ENOG4108JUB Transcriptional regulator M654_015490 ENOG4106CCJ Protein of unknown function (DUF2627) M654_015495 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M654_015500 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_015515 ENOG4107QQR Sporulation M654_015520 ENOG4105S1Z Stage IV sporulation protein B M654_015525 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) M654_015530 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) M654_015535 ENOG4105DX0 Hemolysin A M654_015540 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) M654_015545 ENOG4105CTB Polyprenyl synthetase M654_015550 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) M654_015555 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) M654_015560 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) M654_015565 ENOG4105M7K Involved in the transcription termination process (By similarity) M654_015570 ENOG4108ZSR alkaline shock protein M654_015575 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase M654_015595 ENOG410644B Stage III sporulation protein af M654_015605 ENOG4105KQ4 Stage iii sporulation protein ad M654_015610 ENOG4108CQH stage III sporulation protein AC M654_015615 ENOG4105KR5 Stage iii sporulation protein M654_015620 ENOG4105CD2 stage iii sporulation protein aa M654_015630 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) M654_015635 ENOG4105DC7 peptidase M24 M654_015640 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) M654_015650 ENOG4105CBJ Metal-dependent enzyme M654_015665 ENOG4105KST dependent repressor M654_015670 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) M654_015675 ENOG4105WZW rhodanese family M654_015685 ENOG4107SQ8 Glycine betaine M654_015690 ENOG4108IJ7 Glycine betaine M654_015695 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor M654_015705 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) M654_015710 ENOG4105C0D helicase M654_015735 ENOG4105VFR signal peptidase M654_015775 ENOG4106855 Competence protein M654_015810 ENOG4105C5X domain protein M654_015855 ENOG4105E0M Sulfatase M654_015875 ENOG4107ZXI Rhomboid family M654_015880 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase M654_015885 ENOG4105WDJ 50S ribosomal protein L33 M654_015905 ENOG41068DG YceG-like family M654_015910 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) M654_015915 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) M654_015920 ENOG4105E2Z phosphate ABC transporter (Permease M654_015925 ENOG4105C8U phosphate abc transporter M654_015930 ENOG4105CVA phosphate M654_015935 ENOG4107RF6 penicillin-binding protein M654_015945 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M654_015950 ENOG4105SXS Protein of unknown function (DUF456) M654_015965 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) M654_015970 ENOG41063Y9 M654_015975 ENOG4108U5J '-nucleotidase M654_015980 ENOG4105N80 Ferric uptake regulator, Fur family M654_015985 ENOG4105FAV ABC, transporter M654_015990 ENOG4105FDK ABC transporter M654_015995 ENOG4108JYZ YitT family M654_016000 ENOG41069ZM Protein of unknown function (DUF2624) M654_016005 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) M654_016020 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) M654_016030 ENOG4105EGD dinuclear metal center protein, YbgI family M654_016045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_016050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) M654_016060 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) M654_016070 ENOG4105C38 Glycyl-tRNA synthetase beta subunit M654_016075 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit M654_016080 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) M654_016090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) M654_016095 ENOG4105KG3 cytidine deaminase M654_016100 ENOG4107YR5 Diacylglycerol kinase M654_016105 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) M654_016110 ENOG4105CTJ Metal Dependent Phosphohydrolase M654_016115 ENOG4105C9A Phoh family M654_016120 ENOG4105EI1 sporulation protein yqfd M654_016125 ENOG41068P3 sporulation protein YqfC M654_016135 ENOG4105DI5 UPF0365 protein M654_016140 ENOG4105F7J membrane-bound serine protease M654_016145 ENOG4105KTH gatB Yqey M654_016150 ENOG4105VCC 30S ribosomal protein S21 M654_016160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) M654_016165 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) M654_016170 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) M654_016175 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) M654_016180 ENOG4105CFG Acts as a chaperone (By similarity) M654_016185 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ M654_016190 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) M654_016195 ENOG4105CSA Coproporphyrinogen iii oxidase M654_016200 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) M654_016210 ENOG4108ZRV stage ii sporulation protein p M654_016230 ENOG4105TQK DNA polymerase iii, delta' subunit M654_016240 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 M654_016245 ENOG4108UK2 deaminase M654_016250 ENOG4105KQC Competence protein M654_016260 ENOG4108D32 Methyltransferase M654_016270 ENOG4108WF2 Metal Dependent Phosphohydrolase M654_016275 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) M654_016280 ENOG410812S Rna-binding protein M654_016285 ENOG4105E2X shikimate dehydrogenase M654_016290 ENOG4105CQW ribosome biogenesis GTPase YqeH M654_016295 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase M654_016315 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) M654_016320 ENOG4108JB9 formate dehydrogenase M654_016335 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M654_016345 ENOG4105VRR gCN5-related N-acetyltransferase M654_016390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family M654_016410 ENOG4105KME endoribonuclease L-psp M654_016415 ENOG4105HDK L-asparaginase M654_016420 ENOG4105C6T cysteine synthase M654_016425 ENOG4105KME endoribonuclease L-psp M654_016470 ENOG4105UNS Pfam:DUF419 M654_016495 ENOG4105G6Z alkaline phosphatase M654_016500 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein M654_016505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_016510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_016520 ENOG4108JQ7 (ABC) transporter M654_016525 ENOG4105ECK Fatty Acid Desaturase M654_016530 ENOG4108ZGX Histidine kinase M654_016535 ENOG4108S01 response regulator M654_016540 ENOG4105CAY ferredoxin--nadp reductase M654_016550 ENOG4105CKI cobalamin synthesis protein M654_016555 ENOG4108NNI Beta-lactamase domain-containing protein M654_016560 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) M654_016565 ENOG4105D52 delta-aminolevulinic acid dehydratase M654_016570 ENOG4108UNV SUF system FeS assembly protein, NifU family M654_016575 ENOG4105DSE periplasmic solute binding protein M654_016580 ENOG4105DIK (ABC) transporter M654_016590 ENOG41090U3 tautomerase M654_016605 ENOG4105EWI Short-chain dehydrogenase reductase Sdr M654_016610 ENOG4107Y9E nuclease M654_016630 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein M654_016640 ENOG41087NI Sulfite exporter TauE/SafE M654_016655 ENOG4105WH1 Two component transcriptional regulator luxr family M654_016660 ENOG4105BZU Histidine kinase M654_016685 ENOG4105DSG hydrolase family 43 M654_016690 ENOG4105CT4 transporter M654_016695 ENOG4105EWI Short-chain dehydrogenase reductase Sdr M654_016700 ENOG4108HKT sucrose-6-phosphate hydrolase M654_016705 ENOG4105F3R pts system mannose fructose sorbose family iid M654_016710 ENOG4105ETZ PTS System M654_016715 ENOG4108IQ3 PTS system M654_016720 ENOG4105YHU PTS system M654_016725 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family M654_016730 ENOG4105G7B Protein of unknown function (DUF2992) M654_016755 ENOG4105WDR M654_016760 ENOG41068K0 YCII-related domain M654_016780 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M654_016810 ENOG4105CV8 reductase M654_016815 ENOG4105F27 Major Facilitator M654_016820 ENOG4105KVH Transcriptional regulator M654_016825 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) M654_016830 ENOG4105EXQ uroporphyrinogen iii synthase hem4 M654_016870 ENOG4105D94 Major Facilitator Superfamily M654_016875 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) M654_016880 ENOG41082JN Transcriptional regulator M654_016905 ENOG4105C28 cystathionine M654_016915 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) M654_016920 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) M654_016935 ENOG4107XRG penicillin-binding protein M654_016940 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) M654_016950 ENOG4105CFP Peptidase U32 M654_016955 ENOG4105XYU peptidase (U32 family) M654_016965 ENOG4105HHA aminodeoxychorismate lyase M654_016970 ENOG4105VPH UPF0473 protein M654_016975 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) M654_016980 ENOG4105VBH UPF0297 protein M654_016985 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) M654_016990 ENOG4105C02 permease M654_017000 ENOG41060CR M654_017010 ENOG4105C7H Helicase, RecD TraA family M654_017020 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) M654_017025 ENOG4105C3J Cysteine desulfurase M654_017035 ENOG4105D1H recombination factor protein RarA M654_017040 ENOG4105CUZ uba thif-type nad fad binding protein M654_017050 ENOG4105C9M aspartyl-trna synthetase M654_017055 ENOG4105CUT histidyl-tRNA synthetase M654_017065 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_017070 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) M654_017075 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) M654_017080 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) M654_017085 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) M654_017090 ENOG41067VP Protein of unknown function (DUF1049) M654_017095 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) M654_017105 ENOG4105CKP Polysaccharide Biosynthesis Protein M654_017110 ENOG4108QG2 Membrane M654_017115 ENOG4105NAP M654_017120 ENOG4105VIE preprotein translocase, subunit YajC M654_017125 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) M654_017130 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) M654_017135 ENOG41061AI Protein of unknown function (DUF2905) M654_017140 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) M654_017145 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) M654_017160 ENOG41069DP small acid-soluble spore protein M654_017170 ENOG4105K7W phage-related replication protein M654_017185 ENOG4105CDY transcriptional regulatory protein M654_017195 ENOG4106678 morphogenetic protein associated with SpoVID M654_017200 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) M654_017205 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase M654_017210 ENOG4108IYU L-aspartate oxidase M654_017225 ENOG4105CQC Prephenate dehydratase M654_017230 ENOG41090I5 UPF0735 ACT domain-containing protein M654_017235 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control M654_017245 ENOG4105K46 50S ribosomal protein l27 M654_017250 ENOG4105X36 (ribosomal) protein M654_017255 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) M654_017275 ENOG41082BM Transcriptional regulator, arsr family M654_017280 ENOG4107QMS site-determining protein M654_017285 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) M654_017290 ENOG4105YHC Rod shape-determining protein MreD M654_017300 ENOG4105DFF Rod shape-determining protein mreb M654_017305 ENOG4105W5Q DNA repair protein (RadC M654_017310 ENOG4108Z03 MAF-like protein M654_017320 ENOG4106A3R peptidase M654_017325 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase M654_017330 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) M654_017340 ENOG4106AR7 Spore coat protein M654_017345 ENOG41068KH stage VI sporulation protein D M654_017350 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase M654_017355 ENOG4105D52 delta-aminolevulinic acid dehydratase M654_017365 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) M654_017375 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) M654_017385 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) M654_017390 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) M654_017395 ENOG4108IUQ atp-dependent protease M654_017400 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) M654_017405 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation M654_017415 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) M654_017420 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) M654_017425 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M654_017430 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) M654_017435 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase M654_017440 ENOG4108ZP8 Acetolactate synthase small subunit M654_017445 ENOG4105C7K acetolactate synthase M654_017450 ENOG4105CM2 brancheD-chain amino acid aminotransferase M654_017460 ENOG4107R37 Glutamate dehydrogenase M654_017485 ENOG4105M59 Phosphodiesterase, mj0936 family M654_017490 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) M654_017495 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) M654_017500 ENOG4108XJQ germination protein M654_017505 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) M654_017510 ENOG41067TZ transcriptional regulator, MarR family M654_017515 ENOG4105PFC Transcriptional regulator M654_017520 ENOG4107FW0 short-chain dehydrogenase reductase M654_017530 ENOG4105E33 succinate dehydrogenase M654_017540 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit M654_017555 ENOG4105CFH Aspartokinase M654_017560 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) M654_017565 ENOG4105K63 Thioredoxin M654_017570 ENOG4105C10 Electron transfer flavoprotein M654_017575 ENOG4105BZJ Electron transfer flavoprotein M654_017580 ENOG41060WC Enoyl-CoA hydratase M654_017585 ENOG4107Z3H Transcriptional regulator, TetR family M654_017590 ENOG4105CEY Amp-dependent synthetase and ligase M654_017600 ENOG4105C98 muts2 protein M654_017605 ENOG4105DCG PHP domain protein M654_017615 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) M654_017620 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) M654_017635 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) M654_017640 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) M654_017645 ENOG4108RWN rrna methyltransferase M654_017650 ENOG41067MF small acid-soluble spore protein M654_017665 ENOG410905X membrane-flanked domain protein M654_017685 ENOG4105DRS transport system, permease M654_017700 ENOG4108MDK Dehydrogenase M654_017705 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase M654_017710 ENOG4105EF1 ribulokinase M654_017715 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) M654_017720 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase M654_017725 ENOG4105CN9 Peptidase m42 family protein M654_017735 ENOG410696E Membrane M654_017740 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) M654_017745 ENOG4105VJV 50s ribosomal protein L35 M654_017750 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) M654_017755 ENOG4105DGI Alkaline phosphatase M654_017765 ENOG4105C22 threonyL-tRNA synthetase M654_017770 ENOG4108TDW sporulation protein YtxC M654_017790 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) M654_017800 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) M654_017805 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase M654_017810 ENOG4108NR7 pectate lyase M654_017815 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) M654_017825 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) M654_017830 ENOG4105C2M dna polymerase I M654_017835 ENOG4105BZU Histidine kinase M654_017840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_017845 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) M654_017850 ENOG4108HMX isocitrate dehydrogenase (NADP) M654_017855 ENOG4105BZN citrate synthase M654_017860 ENOG4108VMM UPF0756 membrane protein M654_017865 ENOG4108REF Sporulation integral membrane protein ytvi M654_017870 ENOG4105FS0 cytoplasmic membrane protein M654_017875 ENOG4105CA9 Pyruvate kinase M654_017880 ENOG4105CTQ phosphohexokinase M654_017885 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) M654_017895 ENOG4105C6K Malic enzyme M654_017900 ENOG4105C0B DNA polymerase III (alpha subunit) M654_017905 ENOG4105VV2 M654_017915 ENOG4106EVM M654_017920 ENOG4105SFS phosphoesterase RecJ domain protein M654_017935 ENOG4105U3E Transcriptional regulator M654_017945 ENOG4105E8R UPF0173 metal-dependent hydrolase M654_017955 ENOG4105CH7 arginosuccinase M654_017960 ENOG4105CDH Citrulline--aspartate ligase M654_017965 ENOG4105EPU Molybdenum cofactor synthesis domain protein M654_017970 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) M654_017980 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) M654_017985 ENOG4105KBJ sporulation protein ytfj M654_017995 ENOG4105VK3 rdd domain containing protein M654_018000 ENOG4105D07 Signal peptide peptidase, SppA M654_018010 ENOG4105CW7 secretion protein, HlyD family M654_018020 ENOG41061AU MarR family Transcriptional regulator M654_018025 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) M654_018035 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) M654_018060 ENOG4105U5Y Transcriptional regulator M654_018070 ENOG4105BZU Histidine kinase M654_018075 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) M654_018095 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) M654_018105 ENOG4105F1V Acetoin utilization protein M654_018110 ENOG4105W87 Cbs domain M654_018115 ENOG4105DGU Histone deacetylase M654_018120 ENOG4105ER2 Ompa motb domain protein M654_018125 ENOG4107R0U MotA TolQ exbB proton channel M654_018130 ENOG4105ETE Transcriptional regulator (LacI family M654_018135 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase M654_018160 ENOG4105DFU Cell wall formation (By similarity) M654_018170 ENOG4108VDD TRNA binding domain protein M654_018185 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ M654_018200 ENOG4105C6K Malic enzyme M654_018205 ENOG4105C8F Beta-lactamase domain protein M654_018210 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) M654_018220 ENOG4108V15 phosphotransferase enzyme family M654_018225 ENOG4108IUM Glycogen debranching enzyme M654_018240 ENOG4107F58 2'-5' rna ligase M654_018245 ENOG4105C6T cysteine synthase M654_018255 ENOG4107QSE Dipeptidase M654_018260 ENOG4105C7N Xanthine uracil vitamin C permease M654_018275 ENOG4105YW5 deoR family transcriptional regulator M654_018290 ENOG4105CBX hi0933 family M654_018295 ENOG4105C94 Transporter M654_018310 ENOG41085GJ domain protein M654_018325 ENOG4105MU9 integral membrane protein M654_018330 ENOG4105DDC Oxidoreductase domain protein M654_018340 ENOG4105F5H Glycosyl Hydrolase Family 88 M654_018350 ENOG41075H3 AraC family transcriptional regulator M654_018360 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component M654_018370 ENOG4105NTD Inherit from COG: Hydrolase M654_018380 ENOG4107V2S Transcriptional regulator M654_018385 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase M654_018390 ENOG4105C8T Leucyl-tRNA synthetase M654_018400 ENOG410605W Major Facilitator M654_018410 ENOG4106UBQ M654_018415 ENOG4107R34 abc transporter permease protein M654_018420 ENOG4105C19 ABC transporter M654_018435 ENOG4105WH1 Two component transcriptional regulator luxr family M654_018445 ENOG4107R34 abc transporter permease protein M654_018450 ENOG4105C19 ABC transporter M654_018460 ENOG4105DVE abc transporter atp-binding protein M654_018465 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family M654_018485 ENOG4108JJA ABC, transporter M654_018535 ENOG4105N5T Radical SAM Protein M654_018550 ENOG4105E8V Alpha Beta Hydrolase Fold protein M654_018555 ENOG4108Z0R Transferase M654_018560 ENOG4105YVM Phosphoesterase, PA-phosphatase related M654_018565 ENOG4105BZF Glycosyl transferase (Group 1 M654_018570 ENOG4105CAQ asparagine synthetase M654_018575 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP M654_018600 ENOG4105D2X ABC transporter substrate-binding protein M654_018610 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component M654_018630 ENOG4108RMU ferritin dps family protein M654_018645 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) M654_018650 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) M654_018655 ENOG4108V2W Carbonate dehydratase M654_018660 ENOG4105DSE periplasmic solute binding protein M654_018685 ENOG4105DTQ mandelate racemase muconate lactonizing M654_018690 ENOG4105CEY Amp-dependent synthetase and ligase M654_018695 ENOG4108IPT Naphthoate synthase M654_018700 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) M654_018705 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) M654_018710 ENOG4105E4F Isochorismate synthase M654_018715 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase M654_018730 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) M654_018740 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) M654_018745 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) M654_018855 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase M654_018910 ENOG4105TUA UPF0295 protein M654_018915 ENOG4105G5W regulator Fur family M654_018920 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M654_018925 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase M654_018930 ENOG4107NBY Membrane M654_018935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M654_018940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M654_018945 ENOG4105DEF Extracellular solute-binding protein, family 5 M654_018950 ENOG4108JQ7 (ABC) transporter M654_018955 ENOG4105C3U ABC transporter M654_018960 ENOG4105BZ1 (ABC) transporter M654_018980 ENOG4105CAN Short-chain dehydrogenase reductase Sdr M654_018985 ENOG4106BXE M654_018990 ENOG4105CEN a g-specific adenine glycosylase M654_018995 ENOG41067AE Membrane-bound metal-dependent hydrolase M654_019000 ENOG4105EJV Membrane M654_019010 ENOG4105CKK Glycosyl transferase, family 2 M654_019015 ENOG4107VFR oxidoreductase M654_019040 ENOG410691R Modulates RecA activity (By similarity) M654_019045 ENOG4105ECP epimerase M654_019065 ENOG4107Y03 Nitroreductase M654_019070 ENOG4105JAB phenazine biosynthesis protein, phzf family M654_019100 ENOG4108DMH HTH_ARAC M654_019105 ENOG4105DSG hydrolase family 43 M654_019110 ENOG4105E4I Glycoside hydrolase family 28 M654_019115 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase M654_019125 ENOG4105KVH Transcriptional regulator M654_019135 ENOG4105CI1 PTS System M654_019140 ENOG4108Q3X Transcriptional regulator M654_019145 ENOG4105F8D glycoside hydrolase family 4 M654_019150 ENOG4105KK4 UPF0060 membrane protein M654_019155 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family M654_019165 ENOG4107QKR Dehydrogenase M654_019175 ENOG4107RUY (E1 component), alpha subunit M654_019185 ENOG4105GPN Uncharacterized conserved protein (DUF2294) M654_019190 ENOG4108TWJ NADH dehydrogenase subunit 5 M654_019195 ENOG4105EVH UPF0753 protein M654_019220 ENOG41079KZ Major Facilitator Superfamily M654_019245 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) M654_019255 ENOG4105D7N magnesium and cobalt transport protein CorA M654_019265 ENOG4105DCT glycerol dehydrogenase M654_019290 ENOG4105UPD Calcium Proton M654_019300 ENOG4108ISG Major Facilitator M654_019305 ENOG4107U9T Pfam:Ribonuclease_BN M654_019315 ENOG4105KJF protein tyrosine phosphatase M654_019320 ENOG4105BZG amino acid carrier protein M654_019330 ENOG4107RKG DJ-1/PfpI family M654_019335 ENOG4105CGH 5'-nucleotidase M654_019340 ENOG4108RCM Nitroreductase M654_019345 ENOG4105KVH Transcriptional regulator M654_019355 ENOG4105KBX Transcriptional regulator, TetR family M654_019360 ENOG4105KPY Small multidrug resistance protein M654_019365 ENOG4105RXJ M654_019370 ENOG4107QQG Dehydrogenase M654_019385 ENOG4108DMA Nad-dependent epimerase dehydratase M654_019390 ENOG4105K64 Glycosyl transferase, family 2 M654_019395 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) M654_019400 ENOG410635A Membrane M654_019405 ENOG4107TVC Glycosyl transferase, family 2 M654_019410 ENOG4108SHN Glycosyl transferase, family 2 M654_019430 ENOG4107414 GntR family transcriptional regulator M654_019435 ENOG4105CG3 alpha amylase, catalytic region M654_019440 ENOG4105C5Y PTS System M654_019465 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) M654_019475 ENOG4108RPX mosc domain containing protein M654_019480 ENOG410855V Acylphosphatase M654_019485 ENOG41082BM Transcriptional regulator, arsr family M654_019520 ENOG4107QPK )-transporter M654_019535 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein M654_019540 ENOG4105FDU atp-dependent rna helicase M654_019545 ENOG4105C5H ABC transporter M654_019550 ENOG4105DXB Major Facilitator superfamily M654_019555 ENOG4107SWG transcriptional regulator MERR family M654_019565 ENOG4106A3M Cytochrome p-450 M654_019570 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) M654_019580 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) M654_019585 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) M654_019590 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) M654_019595 ENOG4105CKI cobalamin synthesis protein M654_019605 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase M654_019610 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) M654_019620 ENOG41090KR LysR family transcriptional Regulator M654_019625 ENOG4105C5H ABC transporter M654_019630 ENOG4105C8P )-transporter M654_019635 ENOG4105FKZ Methyl-accepting chemotaxis M654_019640 ENOG4105C26 Dehydrogenase M654_019650 ENOG4105CDY transcriptional regulatory protein M654_019655 ENOG4108PCN EamA-like transporter family M654_019675 ENOG410780I phosphoprotein phosphatase activity M654_019725 ENOG4108HFV M654_019750 ENOG4107EV6 Inherit from COG: YD repeat protein M654_019820 ENOG4105QBX endodeoxyribonuclease RusA M654_019830 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) M654_019835 ENOG4105CBD Diacylglycerol kinase M654_019840 ENOG4105DU0 nucleoside hydrolase M654_019845 ENOG4105D9U N-acetyltransferase M654_019855 ENOG4108IG5 Transcriptional regulator M654_019865 ENOG4105D3P Mannan endo-1,4-beta-mannosidase M654_019870 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) M654_019875 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) M654_019880 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) M654_019885 ENOG4105CK7 Sodium proline symporter M654_019895 ENOG4105KT7 mgtC SapB transporter M654_019905 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) M654_019910 ENOG4105C4R Atp-dependent dna helicase M654_019920 ENOG4105KGF protein, YerC YecD M654_019925 ENOG4108R5T secreted protein M654_019940 ENOG4106A3M Cytochrome p-450 M654_019950 ENOG4105C12 Phosphoribosylglycinamide synthetase M654_019955 ENOG4105DC1 bifunctional purine biosynthesis protein purh M654_019960 ENOG4108V3E phosphoribosylglycinamide formyltransferase M654_019965 ENOG4105CXB phosphoribosylaminoimidazole synthetase M654_019975 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii M654_019985 ENOG4105VR9 phosphoribosylformylglycinamidine synthase M654_019990 ENOG4105C8V SAICAR synthetase M654_019995 ENOG4105C83 adenylosuccinate lyase M654_020000 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit M654_020005 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) M654_020015 ENOG4108U5N UPF0316 protein M654_020025 ENOG4105C7N Xanthine uracil vitamin C permease M654_020030 ENOG4105E5W Transporter M654_020055 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) M654_020070 ENOG4105C7R Atpase associated with various cellular activities aaa_3 M654_020085 ENOG4107STQ Multicopper oxidase M654_020090 ENOG4105UEI Transcriptional Regulator AraC Family M654_020135 ENOG4107URF beta-phospho-glucomutase M654_020140 ENOG4105CG3 alpha amylase, catalytic region M654_020155 ENOG4105EG2 ABC transporter, permease M654_020160 ENOG4105D56 permease protein M654_020165 ENOG4107FKK extracellular solute-binding protein family 1 M654_020170 ENOG4108IUK alpha amylase, catalytic M654_020175 ENOG4105FKQ transcriptional regulator M654_020180 ENOG4105E5K Alpha-amylase M654_020185 ENOG4108ZJ4 polysaccharide deacetylase M654_020205 ENOG4105N14 lysine exporter protein LysE YggA M654_020210 ENOG4108NGU Transcriptional regulator M654_020225 ENOG4105EBR Carboxylesterase M654_020230 ENOG4108VHC Short-chain dehydrogenase reductase Sdr M654_020235 ENOG4105K78 MarR family Transcriptional regulator M654_020245 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) M654_020250 ENOG4108X07 Tetr family transcriptional regulator M654_020265 ENOG4108RAV Conserved protein M654_020280 ENOG4108E16 pectate lyase M654_020295 ENOG4107TCE N-acetyltransferase M654_020315 ENOG4108HKT sucrose-6-phosphate hydrolase M654_020320 ENOG4105EDQ levansucrase EC 2.4.1.10 M654_020330 ENOG4105EQD regulatoR M654_020335 ENOG4105C2F Histidine kinase M654_020340 ENOG4107RHR regulatoR M654_020345 ENOG4105VI0 Pts system, glucitol sorbitol-specific M654_020350 ENOG4105DZY Pts system, glucitol sorbitol-specific M654_020355 ENOG410787A Pts system, glucitol sorbitol-specific M654_020380 ENOG4105CBT Fructose-1,6-bisphosphatase M654_020385 ENOG4108YZG isomerase M654_020390 ENOG4105E98 transcriptional regulator DeoR family M654_020405 ENOG4105CG6 trap dicarboxylate transporter dctm subunit M654_020410 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter M654_020415 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit M654_020420 ENOG4108KFM Xylose Isomerase Domain-Containing protein M654_020425 ENOG4105CHR reductase M654_020430 ENOG4105ETE Transcriptional regulator (LacI family M654_020435 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) M654_020440 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) M654_020445 ENOG4108TYN CAAX amino terminal protease family protein M654_020460 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) M654_020465 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) M654_020475 ENOG4105C5H ABC transporter M654_020480 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) M654_020485 ENOG410801F ribosomal-protein-alanine acetyltransferase M654_020490 ENOG41072GX Peptidase M22 Glycoprotease M654_020495 ENOG4105K8N protein family UPF0079, ATPase M654_020500 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) M654_020550 ENOG4108Z6X (sortase) family M654_020560 ENOG4108NEV two component transcriptional regulator, LytTR family M654_020570 ENOG4105C2C drug resistance transporter, Bcr CflA M654_020575 ENOG4105QV4 Tryptophan halogenase M654_020585 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) M654_020590 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) M654_020595 ENOG4107RHR regulatoR M654_020600 ENOG4105EXC Acyl-transferase M654_020610 ENOG4105X5K response regulator receiver protein M654_020620 ENOG4105CHR reductase M654_020625 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) M654_020640 ENOG4105C85 amino acid M654_020645 ENOG4107XCH Cyclase family M654_020660 ENOG4107RSM transcriptional regulator M654_020665 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase M654_020670 ENOG41090E6 transcriptional regulator MERR family M654_020685 ENOG4105CZ9 Domain of unknown function (DU1801) M654_020690 ENOG41082YX Transcriptional regulator, arsr family M654_020700 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 M654_020705 ENOG4108U05 Transcriptional regulator M654_020715 ENOG4107T94 Endo-14-beta-xylanase M654_020775 ENOG41064BQ Phosphatase M654_020795 ENOG4107SGM protein serine threonine phosphatase M654_020800 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase M654_020805 ENOG4105FUA antagonist M654_020810 ENOG4107MMM Anti-sigma-factor antagonist M654_020815 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) M654_020825 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) M654_020830 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein M654_020840 ENOG4105CKV Membrane M654_020845 ENOG410905X membrane-flanked domain protein M654_020850 ENOG4105C1J atp-dependent rna helicase M654_020860 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) M654_020865 ENOG4105CPF Cell wall formation (By similarity) M654_020870 ENOG4105SZ6 Thioredoxin M654_020885 ENOG4105FDT acyl-CoA dehydrogenase M654_020900 ENOG4105CJ1 ABC, transporter M654_020905 ENOG4105CK2 sodium dicarboxylate symporter M654_020910 ENOG4106F5Q Membrane M654_020915 ENOG4105QVS general stress protein M654_020920 ENOG41082W1 Cupin 2, conserved barrel domain protein M654_020930 ENOG4105EC3 peptidase S51, dipeptidase E M654_020935 ENOG4105EU9 M654_020945 ENOG41087PP glycosyltransferase MGT family M654_020950 ENOG4108IJ0 Aspartate ammonia-lyase M654_020955 ENOG4107BMA Transglycosylase associated protein M654_020960 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) M654_020985 ENOG4105C9U ATP-dependent DNA helicase RecQ M654_021000 ENOG4105VCH membrane M654_021005 ENOG4108RCF TRANSCRIPTIONal M654_021015 ENOG410606W general stress protein M654_021030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr M654_021035 ENOG4105ETD TRANSCRIPTIONal M654_021040 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase M654_021055 ENOG4105XJB lipolytic protein G-D-S-L family M654_021060 ENOG4107258 Transcriptional regulator M654_021070 ENOG4105P4J Allophanate hydrolase, subunit 1 M654_021075 ENOG4105CFM UPF0317 protein M654_021080 ENOG4105C5A transporter M654_021085 ENOG4105E7W lamb ycsf family protein M654_021120 ENOG4107TXC Transcriptional regulator M654_021125 ENOG4105C8P )-transporter M654_021130 ENOG4105DRR Transcriptional regulator, GntR family M654_021140 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) M654_021145 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit M654_021150 ENOG4108IFG nitrite reductase, (NAD(P)H) M654_021155 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) M654_021165 ENOG4108ZYE Transcriptional regulator M654_021170 ENOG4108T5E Copper resistance protein M654_021175 ENOG4105KTB nuclear export factor GLE1 M654_021185 ENOG4108RNG Permease of the drug metabolite transporter M654_021190 ENOG4105EMU Dehydrogenase M654_021195 ENOG4105C26 Dehydrogenase M654_021200 ENOG4107QTZ amino acid M654_021205 ENOG4108JPW Aminotransferase M654_021215 ENOG4105YVS arsR family transcriptional regulator M654_021220 ENOG41067V3 Antibiotic biosynthesis monooxygenase M654_021225 ENOG4108DBC nitroreductase M654_021230 ENOG4105R8C Transcriptional regulator M654_021245 ENOG4108RZ2 Glycoside hydrolase family 16 M654_021260 ENOG4108IPW abc transporter atp-binding protein M654_021265 ENOG4105CM4 permease protein M654_021270 ENOG4105DHS permease protein M654_021275 ENOG4105CFH Aspartokinase M654_021280 ENOG4105EC8 Methyl-accepting chemotaxis M654_021285 ENOG4105BZU Histidine kinase M654_021290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M654_021295 ENOG4107WD8 ABC transporter, permease M654_021310 ENOG4107TXC Transcriptional regulator M654_021325 ENOG4105E1K spore germination protein M654_021340 ENOG4105DUX Transporter M654_021350 ENOG4107T32 3-phytase (EC 3.1.3.8) M654_021355 ENOG4105C4C beta-galactosidase M654_021360 ENOG410645S MarR family Transcriptional regulator M654_021365 ENOG4105DCM major facilitator superfamily M654_021375 ENOG4108HWW ABC transporter M654_021385 ENOG4105DFW ABC transporter M654_021390 ENOG4105WH1 Two component transcriptional regulator luxr family M654_021395 ENOG4105C2F Histidine kinase M654_021465 ENOG41069ZX M654_021470 ENOG41069ZX M654_021475 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) M654_021480 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase M654_021485 ENOG4106P55 Transcriptional regulator M654_021490 ENOG41066UZ arginase EC 3.5.3.1 M654_021495 ENOG4108IQI permease M654_021500 ENOG4105C8Y Acetylornithine aminotransferase M654_021505 ENOG4108JUB Transcriptional regulator M654_021515 ENOG4105DRP amino acid AbC transporter M654_021520 ENOG4105CDA abc transporter atp-binding protein M654_021530 ENOG41067SE Tetr family transcriptional regulator M654_021580 ENOG41086D8 Transcriptional regulator M654_021585 ENOG4108SA1 esterase M654_021590 ENOG4105W8Z 4'-phosphopantetheinyl transferase M654_021600 ENOG4105SX7 Transporter M654_021620 ENOG4105CEY Amp-dependent synthetase and ligase M654_021625 ENOG4105D94 Major Facilitator Superfamily M654_021635 ENOG4105F38 ABC transporter, permease M654_021645 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M654_021675 ENOG4105C8Q Methyl-accepting chemotaxis M654_021685 ENOG4108V5V Serine Threonine protein kinase M654_021690 ENOG4105CS2 ec 3.2.1.21 M654_021705 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein M654_021710 ENOG4105E5Q amino acid AbC transporter M654_021725 ENOG4105I82 acetyl xylan esterase M654_021730 ENOG4108PJD permease M654_021740 ENOG4107YHD transcriptional regulator M654_021745 ENOG4105CK7 Sodium proline symporter M654_021750 ENOG4105C26 Dehydrogenase M654_021760 ENOG410756H nucleotidyltransferase M654_021770 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) M654_021810 ENOG4107QIV Cytochrome c biogenesis protein M654_021820 ENOG4108TTB tellurium resistance protein M654_021835 ENOG4105DAX Pfam:DUF2983 M654_021850 ENOG4107TS3 membrane protein, TerC M654_021855 ENOG4106FN3 tellurium resistance protein M654_021860 ENOG4106FN3 tellurium resistance protein M654_021865 ENOG4108N0M stress protein M654_021890 ENOG4105CIG ABC transporter M654_021900 ENOG4105Z8B NlpC/P60 family M654_021905 ENOG4105DEN Luciferase family M654_021915 ENOG4105KHC sulfurtransferase M654_021925 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases M654_021940 ENOG410901P UPF0249 protein M654_021950 ENOG4105F8D glycoside hydrolase family 4 M654_021955 ENOG4105CK1 PTS System M654_021960 ENOG4105VCP PTS System M654_021970 ENOG4105CQB FAD linked oxidase domain protein M654_021975 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) M654_021980 ENOG41066YJ Beta-lactamase M654_021985 ENOG4107BMA Transglycosylase associated protein M654_021990 ENOG4105DPN Oligoendopeptidase f M654_022000 ENOG4108W0I acetyltransferase M654_022005 ENOG4107RB3 L-asparaginase M654_022035 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) M654_022055 ENOG4105MDS 4-oxalocrotonate tautomerase M654_022060 ENOG4107V2S Transcriptional regulator M654_022085 ENOG4105DA5 (ABC) transporter M654_022095 ENOG41060AI SEC-C motif M654_022105 ENOG4106UX7 integral membrane protein M654_022120 ENOG4107TXC Transcriptional regulator M654_022150 ENOG41067TZ transcriptional regulator, MarR family M654_022195 ENOG4108R1P M654_022205 ENOG4106FGC M654_022230 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M654_022235 ENOG4105CTX dehydratase M654_022240 ENOG41073TP transcriptional regulator M654_022245 ENOG4105EQX glucarate dehydratase M654_022250 ENOG4105DJB Major Facilitator Superfamily M654_022255 ENOG4105C26 Dehydrogenase M654_022260 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase M654_022265 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) M654_022270 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) M654_022275 ENOG4105DGI Alkaline phosphatase M654_022285 ENOG4105NA0 Transcriptional regulator M654_022295 ENOG4105KNA -acetyltransferase M654_022310 ENOG4105CSV Glutaminase M654_022320 ENOG4105MUA Resistance protein M654_022335 ENOG4108QY0 Membrane M654_022350 ENOG4105CI1 PTS System M654_022355 ENOG410901P UPF0249 protein M654_022360 ENOG4108J5H Homocysteine s-methyltransferase M654_022365 ENOG4108IQI permease M654_022370 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid M654_022385 ENOG4105DFW ABC transporter M654_022390 ENOG4105C8Q Methyl-accepting chemotaxis M654_022395 ENOG4107SCQ Iron-containing alcohol dehydrogenase M654_022430 ENOG4106AXJ AraC family transcriptional regulator M654_022435 ENOG410631K Membrane M654_022465 ENOG4107I77 yiaA/B two helix domain M654_022485 ENOG4105EYF MMPL domain protein M654_022490 ENOG41062A4 Transcriptional regulator M654_022505 ENOG4105DRR Transcriptional regulator, GntR family M654_022510 ENOG4108TVJ Nitroreductase M654_022515 ENOG4105DY8 decarboxylase M654_022560 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M654_022565 ENOG4105K4H Nlp p60 protein M654_022590 ENOG4105KVH Transcriptional regulator M654_022595 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein M654_022600 ENOG41087NI Sulfite exporter TauE/SafE M654_022605 ENOG4105VFE sira family M654_022610 ENOG4107TPS domain protein M654_022625 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase M654_022630 ENOG4105XTG Pfam:DUF156 M654_022640 ENOG4105C7Z Conserved Protein M654_022650 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M654_022660 ENOG4105C7Z Conserved Protein M654_022680 ENOG4106DDH Sporulation-specific SASP protein M654_022685 ENOG4105E5W Transporter M654_022700 ENOG4105IE8 Alpha-ketoglutarate permease M654_022705 ENOG4105CTS PTS system mannitol-specific M654_022710 ENOG4105ETD TRANSCRIPTIONal M654_022715 ENOG4105CPQ Dehydrogenase M654_022740 ENOG4105DDN Pentapeptide repeat-containing protein M654_022745 ENOG4105CG9 aspartate racemase M654_022760 ENOG4107ZXU DSBA oxidoreductase M654_022765 ENOG4105BZ1 (ABC) transporter M654_022790 ENOG4105DA5 (ABC) transporter M654_022800 ENOG4108RWP Major Facilitator Superfamily protein M654_022805 ENOG4105WAB arsR family transcriptional regulator M654_022815 ENOG4105KVH Transcriptional regulator M654_022820 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein M654_022835 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) M654_022840 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) M654_022845 ENOG4107U5W ybbr family M654_022850 ENOG4105C8B TIGR00159 family M654_022860 ENOG4105EMN RNA polymerase sigma factor M654_022895 ENOG4105EWC Purine nucleoside phosphorylase M654_022900 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate M654_022920 ENOG4105D17 glycoside hydrolase, family 3 domain protein M654_022925 ENOG4105EHZ conserved protein UCP016719 M654_022930 ENOG4105JAB phenazine biosynthesis protein, phzf family M654_022950 ENOG4108A04 Beta-lactamase M654_022995 ENOG4108NMV polysaccharide deacetylase M654_023010 ENOG4105D1F ATP-binding protein M654_023030 ENOG4108UJD 30S ribosomal protein S9 M654_023035 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) M654_023040 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) M654_023045 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) M654_023050 ENOG4108JJB ABC transporter M654_023055 ENOG4108JJB ABC transporter M654_023060 ENOG4108ZT0 50S ribosomal protein l17 M654_023065 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) M654_023070 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) M654_023075 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits M654_023080 ENOG41067V7 50S ribosomal protein L36 M654_023085 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) M654_023095 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) M654_023100 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) M654_023105 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) M654_023110 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) M654_023120 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) M654_023125 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) M654_023130 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) M654_023135 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) M654_023140 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) M654_023145 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits M654_023150 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) M654_023155 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) M654_023160 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal M654_023165 ENOG41082SA 50s ribosomal protein l29 M654_023170 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) M654_023175 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) M654_023180 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) M654_023185 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) M654_023190 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity M654_023195 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) M654_023200 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) M654_023205 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) M654_023210 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) M654_023215 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) M654_023220 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) M654_023225 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) M654_023230 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) M654_023235 ENOG4105XPM ribosomal protein M654_023240 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) M654_023245 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) M654_023250 ENOG4107Y49 methyltransferase M654_023255 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) M654_023260 ENOG4108VZM 50s ribosomal protein L10 M654_023265 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) M654_023270 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) M654_023275 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) M654_023280 ENOG410683Z Preprotein translocase SecE subunit M654_023290 ENOG4105QIV RNA polymerase M654_023295 ENOG4105M0M Tetracycline resistance protein M654_023300 ENOG4105C2N RNA methyltransferase TrmH family group 3 M654_023305 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) M654_023310 ENOG4105C8N cysteinyl-tRNA synthetase M654_023315 ENOG4105D7W serine acetyltransferase M654_023320 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) M654_023325 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) M654_023330 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) M654_023335 ENOG4105CTP PilT protein domain protein M654_023340 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) M654_023345 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) M654_023355 ENOG41066A3 ATP guanido phosphotransferase M654_023360 ENOG4108Z0C Uvrb UvrC protein