locus-tag	class	description
M654_000005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M654_000010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M654_000015	COG1396	sequence-specific DNA binding
M654_000020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M654_000025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M654_000030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M654_000035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M654_000040	COG0512	Glutamine amidotransferase of anthranilate synthase
M654_000045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M654_000050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M654_000055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M654_000060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M654_000065	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M654_000070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M654_000095	COG0515	serine threonine protein kinase
M654_000100	COG2304	oxidoreductase activity
M654_000105	COG2208	phosphoserine phosphatase activity
M654_000120	COG1098	S1 RNA binding domain
M654_000125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M654_000140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M654_000145	COG3956	TIGRFAM MazG family protein
M654_000150	COG2244	polysaccharide biosynthetic process
M654_000155	COG2002	toxin-antitoxin pair type II binding
M654_000160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M654_000170	COG0193	aminoacyl-tRNA hydrolase activity
M654_000175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M654_000180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M654_000185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M654_000190	COG2088	sporulation resulting in formation of a cellular spore
M654_000195	COG0251	oxidation-reduction process
M654_000200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M654_000205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M654_000215	COG4466	Protein conserved in bacteria
M654_000225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M654_000230	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M654_000235	COG3584	3D domain protein
M654_000235	COG3583	domain protein
M654_000240	COG0084	hydrolase, TatD family'
M654_000245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M654_000245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M654_000250	COG2002	toxin-antitoxin pair type II binding
M654_000255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M654_000260	COG2827	Endonuclease containing a URI domain
M654_000265	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M654_000270	COG4467	Involved in initiation control of chromosome replication
M654_000275	COG1774	PSP1 C-terminal conserved region
M654_000280	COG0470	DNA polymerase III
M654_000285	COG1728	Protein conserved in bacteria
M654_000290	COG3870	Protein conserved in bacteria
M654_000295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M654_000300	COG1982	Orn Lys Arg decarboxylase major
M654_000305	COG3853	Toxic anion resistance protein (TelA)
M654_000310	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M654_000320	COG1113	amino acid transport
M654_000330	COG2318	DinB family
M654_000370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M654_000375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M654_000380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M654_000390	COG0590	tRNA wobble adenosine to inosine editing
M654_000395	COG1335	isochorismatase
M654_000400	COG3858	chitin binding
M654_000400	COG1388	LysM domain
M654_000405	COG1428	Deoxynucleoside kinase
M654_000410	COG1428	Deoxynucleoside kinase
M654_000425	COG3835	regulator
M654_000430	COG2610	gluconate transmembrane transporter activity
M654_000435	COG1929	Belongs to the glycerate kinase type-1 family
M654_000440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M654_000445	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M654_000450	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M654_000455	COG1686	Belongs to the peptidase S11 family
M654_000460	COG0516	GMP reductase activity
M654_000460	COG0517	IMP dehydrogenase activity
M654_000505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M654_000510	COG0187	DNA topoisomerase II activity
M654_000520	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M654_000525	COG2501	S4 domain
M654_000530	COG0592	DNA-directed DNA polymerase activity
M654_000535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M654_000545	COG0594	ribonuclease P activity
M654_000550	COG0706	membrane insertase activity
M654_000555	COG1847	R3H domain protein
M654_000560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M654_000565	COG0445	tRNA wobble uridine modification
M654_000570	COG0357	Ribosomal RNA small subunit methyltransferase G
M654_000575	COG1475	DNA binding
M654_000585	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M654_000590	COG1192	Involved in chromosome partitioning
M654_000595	COG1475	DNA binding
M654_000605	COG3949	Membrane
M654_000610	COG4481	Protein conserved in bacteria
M654_000615	COG0012	GTP binding
M654_000620	COG0360	Binds together with S18 to 16S ribosomal RNA
M654_000625	COG0629	single-stranded DNA binding
M654_000630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M654_000640	COG0659	secondary active sulfate transmembrane transporter activity
M654_000645	COG0589	response to stress
M654_000655	COG2271	Major facilitator Superfamily
M654_000660	COG0659	secondary active sulfate transmembrane transporter activity
M654_000665	COG0589	response to stress
M654_000670	COG5577	PFAM Coat F domain
M654_000675	COG4241	membrane
M654_000680	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M654_000685	COG0359	binds to the 23S rRNA
M654_000690	COG1263	PTS System
M654_000690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_000695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M654_000700	COG2188	Transcriptional regulator
M654_000705	COG0363	glucosamine-6-phosphate deaminase activity
M654_000710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M654_000715	COG2207	Transcriptional regulator
M654_000720	COG2807	transmembrane transport
M654_000730	COG0305	Participates in initiation and elongation during chromosome replication
M654_000735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M654_000740	COG0494	nUDIX hydrolase
M654_000765	COG0745	RESPONSE REGULATOR receiver
M654_000770	COG5002	protein histidine kinase activity
M654_000775	COG4863	YycH protein
M654_000780	COG4853	Protein conserved in bacteria
M654_000785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M654_000790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M654_000805	COG0456	acetyltransferase
M654_000820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M654_000855	COG0789	Transcriptional regulator
M654_000875	COG2197	response regulator
M654_000880	COG4585	Histidine kinase
M654_000885	COG0842	Transport permease protein
M654_000890	COG1131	(ABC) transporter
M654_000905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_000910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_000915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_000930	COG3634	alkyl hydroperoxide reductase activity
M654_000935	COG0450	alkyl hydroperoxide reductase
M654_000940	COG0038	chloride channel
M654_000950	COG1454	alcohol dehydrogenase
M654_000950	COG1012	belongs to the aldehyde dehydrogenase family
M654_000980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M654_000985	COG1846	Transcriptional regulator
M654_000990	COG1940	carbohydrate kinase activity
M654_000995	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M654_001000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M654_001010	COG1609	Transcriptional regulator
M654_001015	COG2182	Extracellular solute-binding protein
M654_001020	COG1175	transmembrane transport
M654_001025	COG3833	ABC-type maltose transport systems, permease component
M654_001030	COG1874	Beta-galactosidase
M654_001035	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M654_001050	COG0686	Belongs to the AlaDH PNT family
M654_001055	COG1115	amino acid carrier protein
M654_001060	COG5278	phosphoserine phosphatase activity
M654_001060	COG0840	transmembrane signaling receptor activity
M654_001070	COG0745	RESPONSE REGULATOR receiver
M654_001075	COG2205	protein histidine kinase activity
M654_001080	COG1136	(ABC) transporter
M654_001085	COG0577	efflux transmembrane transporter activity
M654_001115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_001130	COG0371	Dehydrogenase
M654_001135	COG0561	phosphatase activity
M654_001140	COG0488	(ABC) transporter
M654_001145	COG0326	Molecular chaperone. Has ATPase activity
M654_001155	COG2271	Major facilitator Superfamily
M654_001160	COG0584	glycerophosphoryl diester phosphodiesterase
M654_001165	COG0667	Aldo Keto reductase
M654_001170	COG1349	DNA-binding transcription factor activity
M654_001175	COG1012	belongs to the aldehyde dehydrogenase family
M654_001180	COG3718	enzyme involved in inositol metabolism
M654_001185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M654_001190	COG3962	Belongs to the TPP enzyme family
M654_001195	COG1082	Xylose isomerase domain protein TIM barrel
M654_001200	COG2814	Major facilitator Superfamily
M654_001205	COG0673	inositol 2-dehydrogenase activity
M654_001210	COG1082	Xylose isomerase domain protein TIM barrel
M654_001215	COG1082	Xylose isomerase domain protein TIM barrel
M654_001220	COG0191	fructose-bisphosphate aldolase activity
M654_001230	COG1181	Belongs to the D-alanine--D-alanine ligase family
M654_001245	COG3977	Valine--pyruvate aminotransferase
M654_001255	COG1215	transferase activity, transferring glycosyl groups
M654_001260	COG5298	Protein conserved in bacteria
M654_001265	COG3706	GGDEF domain
M654_001270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M654_001280	COG0457	Tetratricopeptide repeat
M654_001290	COG2390	Transcriptional regulator
M654_001295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M654_001300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M654_001305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M654_001320	COG0513	Belongs to the DEAD box helicase family
M654_001325	COG3507	Belongs to the glycosyl hydrolase 43 family
M654_001335	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M654_001355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_001355	COG2190	(PTS) system
M654_001355	COG1263	PTS System
M654_001360	COG2723	6-phospho-beta-galactosidase activity
M654_001365	COG0745	RESPONSE REGULATOR receiver
M654_001370	COG2205	protein histidine kinase activity
M654_001375	COG1136	(ABC) transporter
M654_001380	COG0577	efflux transmembrane transporter activity
M654_001385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M654_001395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M654_001400	COG2224	Isocitrate lyase
M654_001405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M654_001410	COG4721	ABC-type cobalt transport system, permease component
M654_001415	COG1122	ATPase activity
M654_001420	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M654_001425	COG3711	transcriptional antiterminator
M654_001430	COG1263	PTS System
M654_001430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_001430	COG2190	(PTS) system
M654_001435	COG2723	6-phospho-beta-galactosidase activity
M654_001445	COG0753	catalase activity
M654_001445	COG0693	protein deglycase activity
M654_001455	COG1476	TRANSCRIPTIONal
M654_001460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M654_001485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M654_001490	COG0463	Glycosyl transferase, family 2
M654_001495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M654_001500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M654_001515	COG3414	Phosphotransferase system galactitol-specific IIB component
M654_001520	COG3775	system Galactitol-specific IIC component
M654_001530	COG0235	Class ii aldolase
M654_001550	COG1609	Transcriptional regulator
M654_001560	COG1175	transmembrane transport
M654_001565	COG0395	ABC-type sugar transport system, permease component
M654_001570	COG2223	nitrite transmembrane transporter activity
M654_001575	COG1621	beta-fructofuranosidase activity
M654_001580	COG2195	Cleaves the N-terminal amino acid of tripeptides
M654_001590	COG1595	DNA-templated transcription, initiation
M654_001600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_001605	COG2723	6-phospho-beta-galactosidase activity
M654_001630	COG0745	RESPONSE REGULATOR receiver
M654_001655	COG0549	Belongs to the carbamate kinase family
M654_001665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M654_001670	COG2235	arginine
M654_001675	COG1438	arginine binding
M654_001680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M654_001685	COG4842	Belongs to the WXG100 family
M654_001710	COG1368	sulfuric ester hydrolase activity
M654_001720	COG5444	nuclease activity
M654_001740	COG0584	glycerophosphoryl diester phosphodiesterase
M654_001745	COG3493	citrate carrier protein
M654_001760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M654_001765	COG0726	polysaccharide deacetylase
M654_001775	COG2706	6-phosphogluconolactonase activity
M654_001780	COG1396	sequence-specific DNA binding
M654_001785	COG0252	asparaginase activity
M654_001790	COG1027	Aspartate ammonia-lyase
M654_001795	COG1757	Na H antiporter
M654_001800	COG0281	malic enzyme
M654_001810	COG2116	formate transmembrane transporter activity
M654_001815	COG3001	Fructosamine kinase
M654_001820	COG1271	oxidase subunit
M654_001825	COG1294	oxidase, subunit
M654_001830	COG4988	ABC transporter
M654_001835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M654_001840	COG2311	Membrane
M654_001845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M654_001865	COG0753	catalase activity
M654_001870	COG0753	catalase activity
M654_001875	COG2814	Major facilitator Superfamily
M654_001880	COG1595	DNA-templated transcription, initiation
M654_001900	COG1131	(ABC) transporter
M654_001905	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M654_001910	COG2814	Major facilitator Superfamily
M654_001925	COG2755	lipolytic protein G-D-S-L family
M654_001930	COG1132	(ABC) transporter
M654_001935	COG1695	Transcriptional regulator
M654_001945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M654_001950	COG2079	MmgE PrpD family protein
M654_001970	COG1086	Polysaccharide biosynthesis protein
M654_001980	COG2094	Belongs to the DNA glycosylase MPG family
M654_001985	COG3711	transcriptional antiterminator
M654_001985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_001990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_001995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_002000	COG1447	Phosphotransferase system cellobiose-specific component IIA
M654_002005	COG1486	melibiose metabolic process
M654_002010	COG2814	Major facilitator Superfamily
M654_002015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M654_002020	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M654_002025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M654_002030	COG1696	Membrane protein involved in D-alanine export
M654_002035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M654_002045	COG2357	RelA SpoT domain protein
M654_002050	COG1335	isochorismatase
M654_002055	COG0477	Major facilitator Superfamily
M654_002065	COG2234	aminopeptidase activity
M654_002070	COG1414	Transcriptional regulator
M654_002075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M654_002080	COG0800	Aldolase
M654_002085	COG4948	Mandelate Racemase Muconate Lactonizing
M654_002090	COG2271	Major facilitator Superfamily
M654_002095	COG5522	Integral membrane protein (intg_mem_TP0381)
M654_002100	COG2409	Drug exporters of the RND superfamily
M654_002105	COG2197	response regulator
M654_002110	COG4585	Histidine kinase
M654_002125	COG1442	glycosyl transferase family 8
M654_002130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M654_002135	COG0346	lactoylglutathione lyase activity
M654_002140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M654_002145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M654_002150	COG1346	cytolysis
M654_002155	COG1380	Effector of murein hydrolase LrgA
M654_002170	COG0583	DNA-binding transcription factor activity
M654_002175	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M654_002180	COG0352	thiamine-phosphate diphosphorylase activity
M654_002190	COG2115	Belongs to the xylose isomerase family
M654_002195	COG1070	Carbohydrate kinase
M654_002200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M654_002205	COG3162	membrane
M654_002210	COG0655	NAD(P)H dehydrogenase (quinone) activity
M654_002220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M654_002225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M654_002230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M654_002240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M654_002260	COG0772	Belongs to the SEDS family
M654_002265	COG0772	Belongs to the SEDS family
M654_002270	COG0778	Nitroreductase
M654_002275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M654_002285	COG1404	Belongs to the peptidase S8 family
M654_002295	COG3711	transcriptional antiterminator
M654_002300	COG1263	PTS System
M654_002300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_002305	COG1621	beta-fructofuranosidase activity
M654_002315	COG0351	phosphomethylpyrimidine kinase
M654_002320	COG2323	membrane
M654_002325	COG1216	Glycosyl transferase, family 2
M654_002330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M654_002340	COG2233	PERMEase
M654_002345	COG2363	Small membrane protein
M654_002350	COG2197	response regulator
M654_002360	COG1131	(ABC) transporter
M654_002380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M654_002395	COG0280	phosphate acetyltransferase
M654_002405	COG1414	Transcriptional regulator
M654_002430	COG2814	Major facilitator Superfamily
M654_002455	COG4844	belongs to the
M654_002460	COG1078	dGTPase activity
M654_002465	COG3465	dGTPase activity
M654_002475	COG1942	4-Oxalocrotonate Tautomerase
M654_002480	COG1994	Peptidase M50
M654_002490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M654_002500	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M654_002505	COG0010	Belongs to the arginase family
M654_002510	COG4506	Protein conserved in bacteria
M654_002515	COG0018	arginyl-trna synthetase
M654_002525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M654_002530	COG0247	lactate metabolic process
M654_002530	COG2181	nitrate reductase activity
M654_002535	COG0183	Belongs to the thiolase family
M654_002540	COG1250	3-hydroxyacyl-CoA dehydrogenase
M654_002545	COG1960	acyl-CoA dehydrogenase activity
M654_002550	COG1960	acyl-CoA dehydrogenase activity
M654_002555	COG3343	RNA polymerase activity
M654_002560	COG0504	CTP synthase activity
M654_002565	COG4821	SIS domain
M654_002570	COG2204	response regulator
M654_002575	COG0191	fructose-bisphosphate aldolase activity
M654_002580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M654_002585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M654_002590	COG1494	fructose-1,6-bisphosphatase
M654_002595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M654_002600	COG0254	rRNA binding
M654_002605	COG1435	thymidine kinase activity
M654_002610	COG0281	malic enzyme
M654_002615	COG0679	Auxin Efflux Carrier
M654_002620	COG0789	Transcriptional regulator
M654_002625	COG0346	lactoylglutathione lyase activity
M654_002630	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M654_002635	COG2890	protein-(glutamine-N5) methyltransferase activity
M654_002645	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M654_002650	COG0009	L-threonylcarbamoyladenylate synthase
M654_002655	COG1971	Probably functions as a manganese efflux pump
M654_002660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M654_002665	COG0698	ribose 5-phosphate isomerase
M654_002670	COG4475	Protein of unknown function (DUF436)
M654_002675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M654_002680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M654_002690	COG0356	it plays a direct role in the translocation of protons across the membrane
M654_002695	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M654_002700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M654_002705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M654_002710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M654_002715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M654_002720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M654_002725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M654_002730	COG4836	Membrane
M654_002740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M654_002745	COG2385	sporulation resulting in formation of a cellular spore
M654_002750	COG2304	oxidoreductase activity
M654_002755	COG2304	oxidoreductase activity
M654_002765	COG2223	nitrite transmembrane transporter activity
M654_002770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M654_002775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M654_002780	COG1994	Peptidase M50
M654_002790	COG1959	2 iron, 2 sulfur cluster binding
M654_002795	COG2910	NAD(P)H-binding
M654_002805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_002805	COG2207	Transcriptional regulator
M654_002810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_002815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_002820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_002825	COG2819	hydrolase of the alpha beta superfamily
M654_002830	COG1028	Short-chain dehydrogenase reductase Sdr
M654_002835	COG1169	isochorismate synthase
M654_002840	COG1021	2,3-dihydroxybenzoate-AMP ligase
M654_002845	COG3433	isochorismatase activity
M654_002845	COG1535	isochorismatase
M654_002850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M654_002855	COG3251	PFAM MbtH domain protein
M654_002860	COG0477	Major facilitator Superfamily
M654_002865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M654_002875	COG1247	-acetyltransferase
M654_002880	COG0739	heme binding
M654_002885	COG1595	DNA-templated transcription, initiation
M654_002890	COG0740	serine-type endopeptidase activity
M654_002895	COG0347	Belongs to the P(II) protein family
M654_002900	COG0004	ammonium transporteR
M654_002905	COG1253	flavin adenine dinucleotide binding
M654_002910	COG0598	Magnesium transport protein CorA
M654_002915	COG0517	IMP dehydrogenase activity
M654_002920	COG3361	conserved protein (COG2071)
M654_002925	COG3546	catalase activity
M654_002930	COG1227	inorganic diphosphatase activity
M654_002935	COG0671	phosphoesterase, PA-phosphatase related
M654_002945	COG2814	Major facilitator Superfamily
M654_002950	COG1846	Transcriptional regulator
M654_002960	COG1609	Transcriptional regulator
M654_002965	COG1077	Cell shape determining protein MreB Mrl
M654_002970	COG4786	Flagellar basal body rod
M654_002975	COG4786	Flagellar basal body rod
M654_002980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M654_002985	COG1970	mechanosensitive ion channel activity
M654_003000	COG0629	single-stranded DNA binding
M654_003020	COG3732	PTS system glucitol sorbitol-specific
M654_003030	COG1028	Short-chain dehydrogenase reductase Sdr
M654_003040	COG1349	DNA-binding transcription factor activity
M654_003045	COG0561	phosphatase activity
M654_003050	COG3878	Protein conserved in bacteria
M654_003055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M654_003060	COG4715	Zinc finger, swim domain protein
M654_003070	COG3944	biosynthesis protein
M654_003075	COG4464	protein tyrosine phosphatase activity
M654_003080	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M654_003085	COG2059	Chromate
M654_003090	COG2059	Chromate
M654_003095	COG1522	sequence-specific DNA binding
M654_003100	COG0405	Gamma-glutamyltransferase
M654_003105	COG0583	DNA-binding transcription factor activity
M654_003110	COG0028	Belongs to the TPP enzyme family
M654_003115	COG3527	Alpha-acetolactate decarboxylase
M654_003120	COG2226	methyltransferase
M654_003125	COG0583	DNA-binding transcription factor activity
M654_003130	COG1879	ABC-type sugar transport system periplasmic component
M654_003135	COG1172	Belongs to the binding-protein-dependent transport system permease family
M654_003140	COG1129	ABC transporter
M654_003145	COG1869	D-ribose catabolic process
M654_003150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M654_003155	COG1609	Transcriptional regulator
M654_003160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M654_003170	COG2843	Capsule synthesis protein
M654_003175	COG0791	NLP P60 protein
M654_003180	COG0561	phosphatase activity
M654_003185	COG1316	TRANSCRIPTIONal
M654_003190	COG2814	Major facilitator Superfamily
M654_003195	COG1063	alcohol dehydrogenase
M654_003200	COG1028	Short-chain dehydrogenase reductase Sdr
M654_003205	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M654_003210	COG1609	Transcriptional regulator
M654_003215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M654_003220	COG0800	Aldolase
M654_003230	COG1328	CTP reductase activity
M654_003240	COG1482	cell wall glycoprotein biosynthetic process
M654_003245	COG4193	domain, Protein
M654_003255	COG0438	transferase activity, transferring glycosyl groups
M654_003260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M654_003265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M654_003280	COG4193	domain, Protein
M654_003285	COG1134	teichoic acid transport
M654_003290	COG1682	transport, permease protein
M654_003295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M654_003300	COG0438	transferase activity, transferring glycosyl groups
M654_003305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M654_003310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M654_003315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M654_003320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M654_003325	COG1316	TRANSCRIPTIONal
M654_003335	COG2247	cell wall binding repeat
M654_003335	COG0860	N-Acetylmuramoyl-L-alanine amidase
M654_003345	COG2244	polysaccharide biosynthetic process
M654_003350	COG0297	glycogen (starch) synthase activity
M654_003350	COG0438	transferase activity, transferring glycosyl groups
M654_003355	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M654_003360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M654_003365	COG3307	-O-antigen
M654_003370	COG3206	protein involved in exopolysaccharide biosynthesis
M654_003375	COG1215	transferase activity, transferring glycosyl groups
M654_003380	COG0438	transferase activity, transferring glycosyl groups
M654_003385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M654_003390	COG5492	domain, Protein
M654_003395	COG1316	TRANSCRIPTIONal
M654_003400	COG1739	Uncharacterized protein family UPF0029
M654_003405	COG4585	Histidine kinase
M654_003410	COG2197	response regulator
M654_003415	COG1307	EDD domain protein, DegV family
M654_003420	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M654_003430	COG1040	competence protein
M654_003440	COG2747	anti-sigma28 factor FlgM
M654_003445	COG3418	PFAM FlgN family protein
M654_003450	COG4786	Flagellar basal body rod
M654_003450	COG1256	bacterial-type flagellum assembly
M654_003455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M654_003465	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M654_003470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M654_003475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M654_003485	COG1334	flagellar protein FlaG
M654_003490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M654_003495	COG1516	flagellar protein fliS
M654_003510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M654_003515	COG0653	protein targeting
M654_003525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M654_003530	COG2010	Cytochrome c
M654_003535	COG2884	Cell division ATP-binding protein ftsE
M654_003540	COG2177	Part of the ABC transporter FtsEX involved in
M654_003545	COG3883	PFAM NLP P60 protein
M654_003545	COG0791	NLP P60 protein
M654_003550	COG3279	Response regulator of the LytR AlgR family
M654_003565	COG0473	3-isopropylmalate dehydrogenase activity
M654_003570	COG3409	Peptidoglycan-binding domain 1 protein
M654_003570	COG0793	Belongs to the peptidase S41A family
M654_003580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M654_003590	COG4897	Protein conserved in bacteria
M654_003595	COG0556	nucleotide-excision repair
M654_003600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M654_003615	COG3595	metallopeptidase activity
M654_003620	COG1983	PspC domain protein
M654_003625	COG1950	PFAM Membrane protein of
M654_003630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M654_003635	COG2814	Major facilitator Superfamily
M654_003640	COG1846	Transcriptional regulator
M654_003645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M654_003650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M654_003655	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M654_003660	COG0546	phosphoglycolate phosphatase activity
M654_003665	COG0110	maltose O-acetyltransferase activity
M654_003670	COG3858	chitin binding
M654_003675	COG4990	cell redox homeostasis
M654_003680	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M654_003685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M654_003690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M654_003695	COG0131	Imidazoleglycerol-phosphate dehydratase
M654_003700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M654_003705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M654_003710	COG0107	imidazoleglycerol-phosphate synthase activity
M654_003715	COG0140	phosphoribosyl-ATP diphosphatase activity
M654_003715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M654_003720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M654_003725	COG0457	Tetratricopeptide repeat
M654_003730	COG0492	ferredoxin-NADP+ reductase activity
M654_003735	COG1051	belongs to the nudix hydrolase family
M654_003740	COG1660	Displays ATPase and GTPase activities
M654_003745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M654_003750	COG1481	regulation of sporulation
M654_003755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_003760	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M654_003765	COG1733	regulation of RNA biosynthetic process
M654_003770	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M654_003775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M654_003780	COG0640	Transcriptional regulator
M654_003785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M654_003790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M654_003795	COG0288	reversible hydration of carbon dioxide
M654_003800	COG0659	secondary active sulfate transmembrane transporter activity
M654_003805	COG1078	dGTPase activity
M654_003810	COG1694	Mazg nucleotide pyrophosphohydrolase
M654_003815	COG1611	Belongs to the LOG family
M654_003820	COG0740	serine-type endopeptidase activity
M654_003845	COG1621	beta-fructofuranosidase activity
M654_003850	COG1621	beta-fructofuranosidase activity
M654_003855	COG1902	pentaerythritol trinitrate reductase activity
M654_003860	COG1733	regulation of RNA biosynthetic process
M654_003865	COG2249	NAD(P)H dehydrogenase (quinone) activity
M654_003870	COG1396	sequence-specific DNA binding
M654_003875	COG3944	biosynthesis protein
M654_003880	COG0489	protein tyrosine kinase activity
M654_003885	COG1086	Polysaccharide biosynthesis protein
M654_003890	COG0438	transferase activity, transferring glycosyl groups
M654_003895	COG1215	transferase activity, transferring glycosyl groups
M654_003900	COG0438	transferase activity, transferring glycosyl groups
M654_003910	COG1216	Glycosyl transferase, family 2
M654_003915	COG5039	Polysaccharide pyruvyl transferase
M654_003920	COG1216	Glycosyl transferase, family 2
M654_003925	COG2244	polysaccharide biosynthetic process
M654_003930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M654_003935	COG0110	maltose O-acetyltransferase activity
M654_003940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M654_003945	COG5039	Polysaccharide pyruvyl transferase
M654_003955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M654_003960	COG1620	l-lactate permease
M654_003965	COG2186	Transcriptional regulator
M654_003970	COG0247	lactate metabolic process
M654_003975	COG1139	Iron-sulfur cluster binding protein
M654_003980	COG1556	Lactate utilization protein
M654_004005	COG0583	DNA-binding transcription factor activity
M654_004010	COG1881	PFAM PEBP family protein
M654_004015	COG1404	Belongs to the peptidase S8 family
M654_004015	COG4412	M6 family metalloprotease domain protein
M654_004030	COG1113	amino acid transport
M654_004035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M654_004040	COG2814	Major facilitator Superfamily
M654_004045	COG2390	Transcriptional regulator
M654_004050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M654_004055	COG0126	phosphoglycerate kinase activity
M654_004060	COG0149	triose-phosphate isomerase activity
M654_004065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M654_004070	COG0148	phosphopyruvate hydratase activity
M654_004075	COG0693	protein deglycase activity
M654_004090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_004095	COG4640	response to antibiotic
M654_004100	COG3064	Membrane
M654_004105	COG2095	MarC family integral membrane protein
M654_004110	COG1510	regulation of RNA biosynthetic process
M654_004115	COG0517	IMP dehydrogenase activity
M654_004115	COG1125	glycine betaine transport
M654_004120	COG1174	glycine betaine transport
M654_004125	COG1732	Glycine betaine
M654_004130	COG1174	glycine betaine transport
M654_004135	COG1396	sequence-specific DNA binding
M654_004140	COG1396	sequence-specific DNA binding
M654_004145	COG1476	TRANSCRIPTIONal
M654_004150	COG2002	toxin-antitoxin pair type II binding
M654_004155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M654_004160	COG1647	Serine aminopeptidase, S33
M654_004165	COG0557	exoribonuclease II activity
M654_004170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M654_004185	COG3507	Belongs to the glycosyl hydrolase 43 family
M654_004190	COG5520	Belongs to the glycosyl hydrolase 30 family
M654_004215	COG2140	Oxalate decarboxylase
M654_004225	COG1191	sigma factor activity
M654_004245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M654_004250	COG0673	inositol 2-dehydrogenase activity
M654_004255	COG1819	glycosyl
M654_004265	COG1846	Transcriptional regulator
M654_004275	COG2124	cytochrome p450
M654_004285	COG2814	Major facilitator Superfamily
M654_004300	COG1028	Short-chain dehydrogenase reductase Sdr
M654_004300	COG3347	Dehydrogenase
M654_004310	COG4952	isomerase
M654_004315	COG1070	Carbohydrate kinase
M654_004320	COG1349	DNA-binding transcription factor activity
M654_004325	COG0693	protein deglycase activity
M654_004330	COG1937	Protein conserved in bacteria
M654_004335	COG2608	mercury ion transmembrane transporter activity
M654_004340	COG2217	Heavy metal translocating P-type atpase
M654_004345	COG0803	Belongs to the bacterial solute-binding protein 9 family
M654_004350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M654_004355	COG1121	(ABC) transporter
M654_004360	COG1472	Belongs to the glycosyl hydrolase 3 family
M654_004365	COG1501	Belongs to the glycosyl hydrolase 31 family
M654_004370	COG0395	ABC-type sugar transport system, permease component
M654_004380	COG1653	transport
M654_004385	COG2217	Heavy metal translocating P-type atpase
M654_004390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M654_004395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M654_004420	COG2860	membrane
M654_004430	COG3973	AAA domain
M654_004440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M654_004450	COG1940	carbohydrate kinase activity
M654_004455	COG0656	L-ascorbic acid biosynthetic process
M654_004460	COG2814	Major facilitator Superfamily
M654_004465	COG1368	sulfuric ester hydrolase activity
M654_004480	COG0531	amino acid
M654_004485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_004490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_004495	COG1120	ATPase activity
M654_004500	COG0745	RESPONSE REGULATOR receiver
M654_004510	COG1904	glucuronate isomerase
M654_004515	COG2211	Major facilitator Superfamily
M654_004520	COG1609	Transcriptional regulator
M654_004525	COG0246	Mannitol dehydrogenase
M654_004530	COG2721	sulfolactate sulfo-lyase activity
M654_004540	COG0583	DNA-binding transcription factor activity
M654_004545	COG2258	MOSC domain
M654_004550	COG1028	Short-chain dehydrogenase reductase Sdr
M654_004555	COG1802	Transcriptional regulator
M654_004560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_004565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_004570	COG1120	ATPase activity
M654_004575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M654_004580	COG1454	alcohol dehydrogenase
M654_004600	COG3395	kinase activity
M654_004605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M654_004610	COG1028	Short-chain dehydrogenase reductase Sdr
M654_004615	COG2096	Adenosyltransferase
M654_004620	COG4677	pectinesterase activity
M654_004625	COG4758	membrane
M654_004630	COG1842	Phage shock protein A
M654_004640	COG4758	membrane
M654_004645	COG4585	Histidine kinase
M654_004650	COG2197	response regulator
M654_004665	COG0814	amino acid
M654_004670	COG0697	spore germination
M654_004680	COG0114	fumarate hydratase activity
M654_004685	COG1309	transcriptional regulator
M654_004690	COG2770	Histidine kinase
M654_004690	COG2205	protein histidine kinase activity
M654_004695	COG0745	RESPONSE REGULATOR receiver
M654_004700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M654_004705	COG0783	Belongs to the Dps family
M654_004710	COG1028	Short-chain dehydrogenase reductase Sdr
M654_004715	COG1686	Belongs to the peptidase S11 family
M654_004730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_004735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_004740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_004745	COG1120	ATPase activity
M654_004760	COG5577	PFAM Coat F domain
M654_004775	COG1250	3-hydroxyacyl-CoA dehydrogenase
M654_004775	COG1024	Enoyl-CoA hydratase
M654_004780	COG0183	Belongs to the thiolase family
M654_004785	COG1960	acyl-CoA dehydrogenase activity
M654_004790	COG1393	Belongs to the ArsC family
M654_004795	COG0509	glycine decarboxylation via glycine cleavage system
M654_004805	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M654_004810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M654_004820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M654_004825	COG2011	ABC-type metal ion transport system permease component
M654_004830	COG1464	Belongs to the NlpA lipoprotein family
M654_004835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M654_004845	COG0396	ATPase activity
M654_004850	COG0719	Fe-S assembly protein
M654_004855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M654_004860	COG0822	iron-sulfur transferase activity
M654_004865	COG0719	Fe-S assembly protein
M654_004885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M654_004900	COG2222	sugar isomerase
M654_004905	COG1653	transport
M654_004910	COG1175	transmembrane transport
M654_004915	COG0395	ABC-type sugar transport system, permease component
M654_004920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M654_004925	COG2188	Transcriptional regulator
M654_004930	COG2356	endonuclease I
M654_004940	COG1288	antiporter activity
M654_004950	COG2508	Transcriptional regulator
M654_004955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M654_004960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M654_004965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M654_004970	COG3226	Transcriptional regulator
M654_004980	COG1801	Protein of unknown function DUF72
M654_004985	COG0730	response to heat
M654_004990	COG0737	Belongs to the 5'-nucleotidase family
M654_004995	COG3377	Domain of unknown function (DUF1805)
M654_005005	COG0733	neurotransmitter:sodium symporter activity
M654_005015	COG0739	heme binding
M654_005030	COG4470	Protein conserved in bacteria
M654_005035	COG2445	Protein of unknown function DUF86
M654_005040	COG0647	UMP catabolic process
M654_005055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M654_005060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M654_005065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M654_005070	COG0460	homoserine dehydrogenase
M654_005075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M654_005080	COG0083	homoserine kinase activity
M654_005085	COG4946	Tricorn protease homolog
M654_005085	COG1506	peptidase
M654_005085	COG0823	Involved in the tonB-independent uptake of proteins
M654_005090	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M654_005095	COG4837	Protein of unknown function (DUF1462)
M654_005105	COG3479	Phenolic acid decarboxylase
M654_005110	COG0457	Tetratricopeptide repeat
M654_005120	COG0412	Dienelactone hydrolase
M654_005125	COG1252	NADH dehydrogenase
M654_005130	COG4844	belongs to the
M654_005135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M654_005140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M654_005145	COG0316	Belongs to the HesB IscA family
M654_005150	COG0456	acetyltransferase
M654_005165	COG0492	ferredoxin-NADP+ reductase activity
M654_005170	COG1252	NADH dehydrogenase
M654_005185	COG3584	3D domain protein
M654_005190	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M654_005195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M654_005200	COG2056	Na+-H+ antiporter family
M654_005205	COG1268	BioY protein
M654_005210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M654_005215	COG0686	Belongs to the AlaDH PNT family
M654_005220	COG2508	Transcriptional regulator
M654_005220	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M654_005225	COG1115	amino acid carrier protein
M654_005230	COG4842	Belongs to the WXG100 family
M654_005235	COG5417	Belongs to the EsaB family
M654_005240	COG4499	WXG100 protein secretion system (Wss), protein YukC
M654_005245	COG0433	COG0433 Predicted ATPase
M654_005245	COG1674	ftsk spoiiie
M654_005250	COG1511	domain protein
M654_005260	COG1028	Short-chain dehydrogenase reductase Sdr
M654_005265	COG1418	mRNA catabolic process
M654_005275	COG0628	permease
M654_005290	COG5506	Protein of unknown function (DUF1694)
M654_005295	COG1335	isochorismatase
M654_005300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M654_005305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M654_005320	COG0142	geranyltranstransferase activity
M654_005330	COG4585	Histidine kinase
M654_005335	COG2197	response regulator
M654_005340	COG2050	protein possibly involved in aromatic compounds catabolism
M654_005345	COG1320	monovalent cation:proton antiporter activity
M654_005350	COG2212	antiporter activity
M654_005355	COG1863	multisubunit Na H antiporter MnhE subunit
M654_005360	COG0651	ATP synthesis coupled electron transport
M654_005365	COG1006	Multisubunit Na H antiporter MnhC subunit
M654_005370	COG2111	Na H antiporter
M654_005375	COG2111	Na H antiporter
M654_005375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M654_005385	COG3493	citrate carrier protein
M654_005390	COG0688	phosphatidylethanolamine metabolic process
M654_005395	COG0586	Pfam SNARE associated Golgi protein
M654_005400	COG1183	phosphatidylcholine synthase activity
M654_005405	COG4565	transcriptional regulatory protein
M654_005410	COG3290	protein histidine kinase activity
M654_005420	COG3011	Protein conserved in bacteria
M654_005425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M654_005430	COG2814	Major facilitator Superfamily
M654_005435	COG5018	Exonuclease
M654_005450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M654_005465	COG2267	carboxylic ester hydrolase activity
M654_005470	COG1522	sequence-specific DNA binding
M654_005475	COG0436	Aminotransferase
M654_005480	COG1098	S1 RNA binding domain
M654_005485	COG2155	Conserved Protein
M654_005490	COG1979	alcohol dehydrogenase
M654_005495	COG0166	Belongs to the GPI family
M654_005500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M654_005510	COG2323	membrane
M654_005520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M654_005530	COG2738	Putative neutral zinc metallopeptidase
M654_005535	COG1253	flavin adenine dinucleotide binding
M654_005540	COG5297	Belongs to the glycosyl hydrolase family 6
M654_005545	COG0366	Alpha amylase catalytic
M654_005550	COG0432	Pfam Uncharacterised protein family UPF0047
M654_005555	COG2070	2-Nitropropane dioxygenase
M654_005565	COG0840	transmembrane signaling receptor activity
M654_005570	COG0840	transmembrane signaling receptor activity
M654_005575	COG0840	transmembrane signaling receptor activity
M654_005580	COG0693	protein deglycase activity
M654_005585	COG0673	inositol 2-dehydrogenase activity
M654_005590	COG0628	permease
M654_005595	COG1968	undecaprenyl-diphosphatase activity
M654_005600	COG1408	metallophosphoesterase
M654_005605	COG0726	polysaccharide deacetylase
M654_005610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M654_005625	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
M654_005675	COG1397	ADP-ribosylglycohydrolase
M654_005685	COG4974	Belongs to the 'phage' integrase family
M654_005810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M654_005810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M654_005865	COG1780	Probably involved in ribonucleotide reductase function
M654_005870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M654_005895	COG0756	dUTP diphosphatase activity
M654_005905	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M654_005910	COG3584	3D domain protein
M654_005980	COG1793	dna ligase
M654_006025	COG0582	viral genome integration into host DNA
M654_006135	COG5632	N-Acetylmuramoyl-L-alanine amidase
M654_006135	COG3409	Peptidoglycan-binding domain 1 protein
M654_006135	COG1388	LysM domain
M654_006185	COG0346	lactoylglutathione lyase activity
M654_006195	COG5634	Uncharacterized conserved protein (DUF2278)
M654_006215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M654_006230	COG2323	membrane
M654_006235	COG2323	membrane
M654_006240	COG2720	vancomycin resistance protein
M654_006245	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M654_006255	COG1510	regulation of RNA biosynthetic process
M654_006260	COG1012	belongs to the aldehyde dehydrogenase family
M654_006265	COG1454	alcohol dehydrogenase
M654_006275	COG2318	DinB family
M654_006285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M654_006290	COG0569	domain protein
M654_006295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M654_006300	COG0457	Tetratricopeptide repeat
M654_006315	COG3764	Sortase (surface protein transpeptidase)
M654_006320	COG3859	Proton-coupled thiamine transporter YuaJ
M654_006325	COG1609	Transcriptional regulator
M654_006490	COG1131	(ABC) transporter
M654_006495	COG3559	Exporter of polyketide antibiotics
M654_006500	COG3152	Membrane
M654_006505	COG0457	Tetratricopeptide repeat
M654_006515	COG0710	3-dehydroquinate dehydratase activity
M654_006520	COG4326	sporulation control protein
M654_006525	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M654_006530	COG1116	anion transmembrane transporter activity
M654_006535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M654_006540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M654_006545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M654_006555	COG1476	TRANSCRIPTIONal
M654_006565	COG1131	(ABC) transporter
M654_006585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M654_006595	COG3382	B3 4 domain protein
M654_006600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M654_006610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M654_006615	COG0789	Transcriptional regulator
M654_006620	COG1664	Polymer-forming cytoskeletal
M654_006625	COG1664	Polymer-forming cytoskeletal
M654_006630	COG2766	serine protein kinase
M654_006635	COG2718	Belongs to the UPF0229 family
M654_006640	COG1566	PFAM secretion protein HlyD family protein
M654_006645	COG2814	Major facilitator Superfamily
M654_006650	COG0655	NAD(P)H dehydrogenase (quinone) activity
M654_006665	COG1725	Transcriptional regulator
M654_006670	COG1131	(ABC) transporter
M654_006675	COG1131	(ABC) transporter
M654_006680	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M654_006685	COG1278	Cold shock
M654_006690	COG1823	symporter activity
M654_006715	COG5577	PFAM Coat F domain
M654_006725	COG5002	protein histidine kinase activity
M654_006730	COG4085	toxin activity
M654_006730	COG0737	Belongs to the 5'-nucleotidase family
M654_006730	COG1525	nuclease
M654_006735	COG3764	Sortase (surface protein transpeptidase)
M654_006745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M654_006750	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M654_006760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M654_006770	COG4175	Glycine betaine
M654_006770	COG3448	diguanylate cyclase activity
M654_006795	COG1733	regulation of RNA biosynthetic process
M654_006800	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M654_006805	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M654_006815	COG0564	pseudouridine synthase activity
M654_006825	COG0517	IMP dehydrogenase activity
M654_006830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M654_006835	COG3153	acetyltransferase
M654_006835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M654_006840	COG0488	(ABC) transporter
M654_006855	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M654_006860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M654_006865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M654_006870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M654_006875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M654_006890	COG2203	Gaf domain
M654_006890	COG4585	Histidine kinase
M654_006895	COG2197	response regulator
M654_006900	COG0431	NADPH-dependent FMN reductase
M654_006915	COG1959	2 iron, 2 sulfur cluster binding
M654_006920	COG1017	nitric oxide dioxygenase activity
M654_006920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M654_006925	COG2719	SpoVR family
M654_006930	COG0791	NLP P60 protein
M654_006930	COG1388	LysM domain
M654_006935	COG0583	DNA-binding transcription factor activity
M654_006940	COG0372	Belongs to the citrate synthase family
M654_006945	COG0733	neurotransmitter:sodium symporter activity
M654_006955	COG2207	Transcriptional regulator
M654_006955	COG3708	Transcriptional regulator
M654_006960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M654_006965	COG0456	acetyltransferase
M654_006980	COG1595	DNA-templated transcription, initiation
M654_006990	COG0204	Acyl-transferase
M654_007005	COG3152	Membrane
M654_007010	COG1253	flavin adenine dinucleotide binding
M654_007015	COG0789	Transcriptional regulator
M654_007020	COG1253	flavin adenine dinucleotide binding
M654_007035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M654_007040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M654_007045	COG0584	glycerophosphoryl diester phosphodiesterase
M654_007055	COG0668	transmembrane transport
M654_007060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M654_007075	COG0726	polysaccharide deacetylase
M654_007085	COG1757	Na H antiporter
M654_007090	COG2017	converts alpha-aldose to the beta-anomer
M654_007115	COG0589	response to stress
M654_007120	COG1132	(ABC) transporter
M654_007125	COG1132	(ABC) transporter
M654_007130	COG0702	epimerase
M654_007145	COG3842	ATPase activity
M654_007150	COG2508	Transcriptional regulator
M654_007160	COG0189	ligase activity
M654_007165	COG0189	ligase activity
M654_007180	COG4399	Belongs to the UPF0754 family
M654_007185	COG3679	Belongs to the UPF0342 family
M654_007190	COG0561	phosphatase activity
M654_007195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M654_007200	COG1024	Enoyl-CoA hydratase
M654_007205	COG0457	Tetratricopeptide repeat
M654_007220	COG4152	abc transporter atp-binding protein
M654_007225	COG1668	transmembrane transport
M654_007230	COG0420	3'-5' exonuclease activity
M654_007235	COG4717	serine-type aminopeptidase activity
M654_007240	COG3481	metal-dependent phosphohydrolase, HD sub domain
M654_007250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M654_007280	COG1846	Transcriptional regulator
M654_007285	COG4980	gas vesicle protein
M654_007300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M654_007305	COG0537	adenosine 5'-monophosphoramidase activity
M654_007310	COG1131	(ABC) transporter
M654_007315	COG4473	ABC transporter
M654_007325	COG1473	amidohydrolase
M654_007330	COG3069	C4-dicarboxylate transmembrane transporter activity
M654_007335	COG2329	Antibiotic biosynthesis monooxygenase
M654_007340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M654_007345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M654_007360	COG1309	transcriptional regulator
M654_007365	COG1511	domain protein
M654_007370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M654_007375	COG1363	Peptidase, m42
M654_007385	COG1301	dicarboxylic acid transport
M654_007395	COG1234	tRNA 3'-trailer cleavage
M654_007400	COG0095	Lipoate-protein ligase
M654_007405	COG0318	PFAM AMP-dependent synthetase and ligase
M654_007415	COG1396	sequence-specific DNA binding
M654_007430	COG0501	Belongs to the peptidase M48B family
M654_007440	COG0697	spore germination
M654_007445	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M654_007450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_007455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_007460	COG0406	alpha-ribazole phosphatase activity
M654_007465	COG0183	Belongs to the thiolase family
M654_007470	COG0318	PFAM AMP-dependent synthetase and ligase
M654_007475	COG1268	BioY protein
M654_007480	COG0840	transmembrane signaling receptor activity
M654_007485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M654_007485	COG0723	plastoquinol--plastocyanin reductase activity
M654_007490	COG1028	Short-chain dehydrogenase reductase Sdr
M654_007500	COG4903	ComK protein
M654_007510	COG0398	Pfam SNARE associated Golgi protein
M654_007515	COG0681	Belongs to the peptidase S26 family
M654_007520	COG1404	Belongs to the peptidase S8 family
M654_007525	COG0457	Tetratricopeptide repeat
M654_007535	COG1609	Transcriptional regulator
M654_007540	COG1653	transport
M654_007545	COG1175	transmembrane transport
M654_007550	COG0395	ABC-type sugar transport system, permease component
M654_007555	COG1486	melibiose metabolic process
M654_007560	COG3180	Ammonia monooxygenase
M654_007575	COG3546	catalase activity
M654_007580	COG0318	PFAM AMP-dependent synthetase and ligase
M654_007585	COG4533	DNA binding
M654_007595	COG5002	protein histidine kinase activity
M654_007600	COG0745	RESPONSE REGULATOR receiver
M654_007605	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M654_007610	COG0725	ABC transporter, periplasmic molybdate-binding protein
M654_007615	COG4149	molybdate abc transporter
M654_007620	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M654_007625	COG1074	ATP-dependent DNA helicase activity
M654_007630	COG0420	3'-5' exonuclease activity
M654_007635	COG0419	ATPase involved in DNA repair
M654_007680	COG5337	Spore coat protein CotH
M654_007690	COG0179	Fumarylacetoacetate (FAA) hydrolase
M654_007710	COG0367	asparagine synthase
M654_007715	COG0004	ammonium transporteR
M654_007720	COG0347	Belongs to the P(II) protein family
M654_007725	COG0534	Mate efflux family protein
M654_007730	COG2207	Transcriptional regulator
M654_007730	COG1917	Cupin 2, conserved barrel domain protein
M654_007750	COG0697	spore germination
M654_007755	COG1279	arginine transmembrane transporter activity
M654_007760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M654_007770	COG0076	glutamate decarboxylase activity
M654_007795	COG2153	protein acetylation
M654_007800	COG1028	Short-chain dehydrogenase reductase Sdr
M654_007810	COG0646	methionine synthase
M654_007810	COG1410	methionine synthase
M654_007815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M654_007815	COG0646	methionine synthase
M654_007820	COG1666	GTP binding
M654_007825	COG2996	Protein conserved in bacteria
M654_007840	COG1307	EDD domain protein, DegV family
M654_007845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M654_007855	COG0516	GMP reductase activity
M654_007865	COG0561	phosphatase activity
M654_007870	COG1073	alpha beta
M654_007875	COG2151	metal-sulfur cluster biosynthetic enzyme
M654_007885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M654_007890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M654_007895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M654_007900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M654_007905	COG0505	Belongs to the CarA family
M654_007910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M654_007915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M654_007920	COG1968	undecaprenyl-diphosphatase activity
M654_007935	COG2267	carboxylic ester hydrolase activity
M654_007945	COG1744	ABC transporter substrate-binding protein PnrA-like
M654_007960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M654_007965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M654_007970	COG5504	Zn-dependent protease
M654_007975	COG0444	Belongs to the ABC transporter superfamily
M654_007980	COG4608	Belongs to the ABC transporter superfamily
M654_007990	COG0601	transmembrane transport
M654_007995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M654_008005	COG0180	Tryptophanyl-tRNA synthetase
M654_008015	COG0601	transmembrane transport
M654_008020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M654_008025	COG0444	Belongs to the ABC transporter superfamily
M654_008030	COG4608	Belongs to the ABC transporter superfamily
M654_008035	COG0456	acetyltransferase
M654_008040	COG1393	Belongs to the ArsC family
M654_008045	COG0861	Integral membrane protein TerC family
M654_008055	COG4862	establishment of competence for transformation
M654_008080	COG4565	transcriptional regulatory protein
M654_008085	COG3290	protein histidine kinase activity
M654_008090	COG4469	Competence protein
M654_008095	COG1164	Oligoendopeptidase f
M654_008105	COG2346	COG2346, Truncated hemoglobins
M654_008110	COG0741	lytic transglycosylase activity
M654_008115	COG4116	CYTH
M654_008125	COG2357	RelA SpoT domain protein
M654_008130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M654_008135	COG0564	pseudouridine synthase activity
M654_008140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M654_008145	COG0475	glutathione-regulated potassium exporter activity
M654_008145	COG0569	domain protein
M654_008150	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M654_008155	COG0352	thiamine-phosphate diphosphorylase activity
M654_008165	COG2104	thiamine diphosphate biosynthetic process
M654_008170	COG2022	thiamine diphosphate biosynthetic process
M654_008175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M654_008180	COG0351	phosphomethylpyrimidine kinase
M654_008185	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M654_008240	COG0210	DNA helicase
M654_008250	COG0586	Pfam SNARE associated Golgi protein
M654_008255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M654_008260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M654_008265	COG2246	polysaccharide biosynthetic process
M654_008270	COG2153	protein acetylation
M654_008275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M654_008280	COG2382	esterase
M654_008300	COG0626	cystathionine gamma-synthase activity
M654_008305	COG0626	cystathionine gamma-synthase activity
M654_008310	COG5505	Protein of unknown function (DUF819)
M654_008330	COG3507	Belongs to the glycosyl hydrolase 43 family
M654_008335	COG1472	Belongs to the glycosyl hydrolase 3 family
M654_008345	COG1472	Belongs to the glycosyl hydrolase 3 family
M654_008350	COG1472	Belongs to the glycosyl hydrolase 3 family
M654_008360	COG1216	Glycosyl transferase, family 2
M654_008365	COG0562	UDP-galactopyranose mutase
M654_008370	COG1940	carbohydrate kinase activity
M654_008470	COG0582	viral genome integration into host DNA
M654_008495	COG0582	viral genome integration into host DNA
M654_008515	COG1476	TRANSCRIPTIONal
M654_008585	COG0305	Participates in initiation and elongation during chromosome replication
M654_008600	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M654_008635	COG0457	Tetratricopeptide repeat
M654_008640	COG5444	nuclease activity
M654_008675	COG1783	phage Terminase large subunit
M654_008685	COG2369	cell adhesion
M654_008695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M654_008700	COG4653	Phage capsid family
M654_008755	COG3953	SLT domain
M654_008755	COG5280	Phage tail tape measure protein TP901
M654_008755	COG3953	SLT domain
M654_008755	COG5280	Phage tail tape measure protein TP901
M654_008760	COG1652	LysM domain
M654_008765	COG4193	domain, Protein
M654_008775	COG3628	GPW Gp25 family protein
M654_008780	COG3299	homolog of phage Mu protein gp47
M654_008785	COG3778	Protein conserved in bacteria
M654_008850	COG0110	maltose O-acetyltransferase activity
M654_008865	COG0673	inositol 2-dehydrogenase activity
M654_008870	COG0109	protoheme IX farnesyltransferase activity
M654_008875	COG0583	DNA-binding transcription factor activity
M654_008880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M654_008885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M654_008890	COG0583	DNA-binding transcription factor activity
M654_008895	COG0697	spore germination
M654_008900	COG0346	lactoylglutathione lyase activity
M654_008910	COG3584	3D domain protein
M654_008910	COG1388	LysM domain
M654_008915	COG2814	Major facilitator Superfamily
M654_008920	COG1309	transcriptional regulator
M654_008930	COG4195	phage-related replication protein
M654_008935	COG2856	Zn peptidase
M654_008940	COG1396	sequence-specific DNA binding
M654_008955	COG1522	sequence-specific DNA binding
M654_008960	COG1484	DNA-dependent DNA replication
M654_008975	COG1595	DNA-templated transcription, initiation
M654_008980	COG5484	DNA packaging
M654_008980	COG3728	DNA packaging
M654_008985	COG1783	phage Terminase large subunit
M654_008990	COG5518	Phage portal protein
M654_008995	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M654_009000	COG4653	Phage capsid family
M654_009055	COG3953	SLT domain
M654_009055	COG5280	Phage tail tape measure protein TP901
M654_009055	COG5280	Phage tail tape measure protein TP901
M654_009055	COG3953	SLT domain
M654_009060	COG1652	LysM domain
M654_009065	COG4193	domain, Protein
M654_009075	COG3628	GPW Gp25 family protein
M654_009080	COG3299	homolog of phage Mu protein gp47
M654_009085	COG3778	Protein conserved in bacteria
M654_009105	COG0584	glycerophosphoryl diester phosphodiesterase
M654_009130	COG1802	Transcriptional regulator
M654_009135	COG1063	alcohol dehydrogenase
M654_009140	COG1312	Catalyzes the dehydration of D-mannonate
M654_009145	COG1028	Short-chain dehydrogenase reductase Sdr
M654_009150	COG1063	alcohol dehydrogenase
M654_009155	COG2271	Major facilitator Superfamily
M654_009175	COG0306	phosphate transporter
M654_009180	COG1392	Phosphate transport regulator
M654_009185	COG0405	Gamma-glutamyltransferase
M654_009190	COG5578	integral membrane protein
M654_009195	COG2972	Histidine kinase
M654_009200	COG4753	response regulator
M654_009200	COG2207	Transcriptional regulator
M654_009205	COG1653	transport
M654_009210	COG1175	transmembrane transport
M654_009215	COG0395	ABC-type sugar transport system, permease component
M654_009220	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M654_009225	COG2207	Transcriptional regulator
M654_009230	COG2755	lipolytic protein G-D-S-L family
M654_009240	COG5578	integral membrane protein
M654_009245	COG3401	FG-GAP repeat protein
M654_009250	COG2755	lipolytic protein G-D-S-L family
M654_009255	COG3401	FG-GAP repeat protein
M654_009265	COG2755	lipolytic protein G-D-S-L family
M654_009270	COG1874	Beta-galactosidase
M654_009280	COG1653	transport
M654_009285	COG4209	transmembrane transport
M654_009290	COG0395	ABC-type sugar transport system, permease component
M654_009295	COG0531	amino acid
M654_009300	COG0346	lactoylglutathione lyase activity
M654_009305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M654_009325	COG3677	Transposase
M654_009375	COG2362	D-Aminopeptidase
M654_009380	COG0601	transmembrane transport
M654_009385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M654_009390	COG0444	Belongs to the ABC transporter superfamily
M654_009395	COG4166	transmembrane transport
M654_009400	COG1619	proteins homologs of microcin C7 resistance protein MccF
M654_009405	COG4948	Mandelate Racemase Muconate Lactonizing
M654_009410	COG0791	NLP P60 protein
M654_009415	COG4608	Belongs to the ABC transporter superfamily
M654_009425	COG1834	amidinotransferase
M654_009430	COG1607	acyl-coa hydrolase
M654_009435	COG3866	Pectate lyase
M654_009450	COG2318	DinB family
M654_009455	COG2076	Multidrug Resistance protein
M654_009460	COG2076	Multidrug Resistance protein
M654_009465	COG0788	formyltetrahydrofolate deformylase activity
M654_009470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M654_009475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M654_009480	COG1764	response to oxidative stress
M654_009485	COG1846	Transcriptional regulator
M654_009490	COG1764	response to oxidative stress
M654_009500	COG0590	tRNA wobble adenosine to inosine editing
M654_009505	COG0406	alpha-ribazole phosphatase activity
M654_009520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M654_009525	COG1404	Belongs to the peptidase S8 family
M654_009535	COG2239	Acts as a magnesium transporter
M654_009545	COG0789	Transcriptional regulator
M654_009555	COG1846	Transcriptional regulator
M654_009560	COG1793	dna ligase
M654_009560	COG3285	dna ligase
M654_009565	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M654_009570	COG5001	Diguanylate cyclase
M654_009570	COG3300	MHYT domain
M654_009575	COG0586	Pfam SNARE associated Golgi protein
M654_009580	COG0861	Integral membrane protein TerC family
M654_009585	COG1191	sigma factor activity
M654_009605	COG0501	Belongs to the peptidase M48B family
M654_009610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M654_009615	COG0768	penicillin binding
M654_009625	COG3594	Acyltransferase
M654_009630	COG5002	protein histidine kinase activity
M654_009635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M654_009640	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M654_009645	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M654_009650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M654_009655	COG0436	Aminotransferase
M654_009660	COG1850	ribulose-bisphosphate carboxylase activity
M654_009665	COG0235	Class ii aldolase
M654_009665	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M654_009670	COG0235	Class ii aldolase
M654_009670	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M654_009675	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M654_009680	COG0346	lactoylglutathione lyase activity
M654_009685	COG3339	Conserved Protein
M654_009700	COG1846	Transcriptional regulator
M654_009705	COG1360	Flagellar Motor Protein
M654_009710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M654_009715	COG0542	response to heat
M654_009720	COG3949	Membrane
M654_009725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M654_009730	COG0720	synthase
M654_009735	COG0602	queuosine metabolic process
M654_009740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M654_009770	COG0457	Tetratricopeptide repeat
M654_009785	COG3739	integral membrane protein
M654_009790	COG3655	Transcriptional regulator
M654_009820	COG4873	Protein conserved in bacteria
M654_009830	COG3773	Cell wall hydrolase
M654_009835	COG2244	polysaccharide biosynthetic process
M654_009840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M654_009845	COG2217	Heavy metal translocating P-type atpase
M654_009850	COG0006	proline dipeptidase activity
M654_009860	COG1609	Transcriptional regulator
M654_009865	COG3711	transcriptional antiterminator
M654_009870	COG2190	(PTS) system
M654_009870	COG1263	PTS System
M654_009870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_009875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_009880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M654_009890	COG1533	DNA photolyase activity
M654_009895	COG0456	acetyltransferase
M654_009900	COG0840	transmembrane signaling receptor activity
M654_009905	COG1028	Short-chain dehydrogenase reductase Sdr
M654_009910	COG2084	Dehydrogenase
M654_009915	COG2340	Cysteine-rich secretory protein family
M654_009920	COG0768	penicillin binding
M654_009925	COG4191	Histidine kinase
M654_009930	COG0436	Aminotransferase
M654_009940	COG1714	RDD family
M654_009950	COG0784	Response regulator, receiver
M654_009950	COG0835	chemotaxis
M654_009960	COG2814	Major facilitator Superfamily
M654_009965	COG1376	ErfK ybiS ycfS ynhG family protein
M654_009970	COG1408	metallophosphoesterase
M654_009975	COG1028	Short-chain dehydrogenase reductase Sdr
M654_009980	COG2200	EAL domain
M654_009985	COG4703	Protein of unknown function (DUF1797)
M654_009990	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M654_010000	COG0517	IMP dehydrogenase activity
M654_010005	COG0583	DNA-binding transcription factor activity
M654_010010	COG0716	FMN binding
M654_010020	COG0716	FMN binding
M654_010025	COG2171	N-acyltransferase activity
M654_010030	COG1473	amidohydrolase
M654_010040	COG0450	alkyl hydroperoxide reductase
M654_010045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M654_010060	COG0746	molybdenum cofactor guanylyltransferase activity
M654_010065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M654_010070	COG0303	'Molybdopterin
M654_010075	COG1763	Mo-molybdopterin cofactor biosynthetic process
M654_010080	COG0314	molybdopterin synthase activity
M654_010085	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M654_010095	COG1132	(ABC) transporter
M654_010100	COG1132	(ABC) transporter
M654_010110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M654_010115	COG1136	(ABC) transporter
M654_010120	COG0577	efflux transmembrane transporter activity
M654_010130	COG1349	DNA-binding transcription factor activity
M654_010135	COG1105	Belongs to the carbohydrate kinase PfkB family
M654_010140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M654_010140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M654_010140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_010155	COG0488	(ABC) transporter
M654_010165	COG2309	aminopeptidase activity
M654_010175	COG1077	Cell shape determining protein MreB Mrl
M654_010180	COG2002	toxin-antitoxin pair type II binding
M654_010185	COG3852	Histidine kinase
M654_010190	COG0569	domain protein
M654_010195	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M654_010200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M654_010210	COG0561	phosphatase activity
M654_010215	COG0242	peptide deformylase activity
M654_010225	COG0497	DNA recombination
M654_010230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M654_010235	COG0022	dehydrogenase e1 component
M654_010240	COG0508	dehydrogenase complex catalyzes the overall conversion of
M654_010245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M654_010250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M654_010260	COG1982	Orn Lys Arg decarboxylase major
M654_010265	COG4476	Belongs to the UPF0223 family
M654_010270	COG4493	Belongs to the UPF0637 family
M654_010280	COG0483	inositol monophosphate 1-phosphatase activity
M654_010305	COG2211	Major facilitator Superfamily
M654_010325	COG1846	Transcriptional regulator
M654_010330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M654_010335	COG4896	Protein conserved in bacteria
M654_010345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M654_010350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M654_010355	COG2066	Belongs to the glutaminase family
M654_010360	COG4838	Belongs to the UPF0358 family
M654_010365	COG0772	Belongs to the SEDS family
M654_010370	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M654_010375	COG1612	heme a metabolic process
M654_010380	COG0109	protoheme IX farnesyltransferase activity
M654_010385	COG2010	Cytochrome c
M654_010385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M654_010390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M654_010395	COG1845	cytochrome c oxidase, subunit III
M654_010400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M654_010405	COG3336	cytochrome c oxidase
M654_010415	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M654_010420	COG2340	Cysteine-rich secretory protein family
M654_010435	COG3679	Belongs to the UPF0342 family
M654_010440	COG4471	UPF0298 protein
M654_010445	COG0742	ribosomal rna small subunit methyltransferase
M654_010450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M654_010455	COG3314	Sporulation integral membrane protein YlbJ
M654_010460	COG3480	Lon protease (S16) C-terminal proteolytic domain
M654_010465	COG1323	Belongs to the UPF0348 family
M654_010470	COG1399	metal-binding, possibly nucleic acid-binding protein
M654_010475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M654_010485	COG0454	-acetyltransferase
M654_010490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M654_010495	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M654_010500	COG2001	Belongs to the MraZ family
M654_010505	COG0275	rRNA processing
M654_010510	COG4839	cell division protein FtsL
M654_010520	COG0768	penicillin binding
M654_010525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M654_010530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M654_010535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M654_010540	COG0772	Belongs to the SEDS family
M654_010545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M654_010550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M654_010555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M654_010560	COG3879	Bacterial protein of unknown function (DUF881)
M654_010565	COG3879	Bacterial protein of unknown function (DUF881)
M654_010570	COG3856	small basic protein
M654_010575	COG0849	cell division
M654_010580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M654_010585	COG4412	M6 family metalloprotease domain protein
M654_010585	COG1404	Belongs to the peptidase S8 family
M654_010590	COG4412	M6 family metalloprotease domain protein
M654_010590	COG1404	Belongs to the peptidase S8 family
M654_010600	COG1191	sigma factor activity
M654_010605	COG1191	sigma factor activity
M654_010610	COG1119	ATPase activity
M654_010615	COG0500	methyltransferase
M654_010620	COG1873	PFAM PRC-barrel domain
M654_010630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M654_010635	COG1799	cell septum assembly
M654_010640	COG0762	integral membrane protein
M654_010645	COG2302	S4 RNA-binding domain
M654_010650	COG3599	regulation of cell shape
M654_010655	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M654_010660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M654_010665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M654_010670	COG0564	pseudouridine synthase activity
M654_010675	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M654_010680	COG2233	PERMEase
M654_010685	COG0540	Belongs to the ATCase OTCase family
M654_010690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M654_010695	COG0505	Belongs to the CarA family
M654_010700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M654_010705	COG0543	2 iron, 2 sulfur cluster binding
M654_010710	COG0167	dihydroorotate dehydrogenase activity
M654_010715	COG0284	orotidine-5'-phosphate decarboxylase activity
M654_010720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M654_010730	COG0175	sulfate reduction
M654_010735	COG0306	phosphate transporter
M654_010740	COG2046	Belongs to the sulfate adenylyltransferase family
M654_010745	COG0529	Catalyzes the synthesis of activated sulfate
M654_010750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M654_010755	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M654_010760	COG1648	precorrin-2 dehydrogenase activity
M654_010765	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M654_010770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M654_010775	COG1561	YicC-like family, N-terminal region
M654_010780	COG2052	Domain of unknown function (DUF370)
M654_010785	COG0194	GDP metabolic process
M654_010790	COG1758	RNA polymerase activity
M654_010795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M654_010800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M654_010805	COG0242	peptide deformylase activity
M654_010810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M654_010815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M654_010815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M654_010820	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M654_010825	COG0631	protein serine/threonine phosphatase activity
M654_010830	COG0515	serine threonine protein kinase
M654_010830	COG2815	serine threonine protein kinase
M654_010835	COG1162	GTPase activity
M654_010840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M654_010845	COG1564	THIamine pyrophosphokinase
M654_010855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M654_010860	COG1302	Protein conserved in bacteria
M654_010865	COG1461	Dihydroxyacetone kinase
M654_010870	COG1760	l-serine dehydratase
M654_010875	COG1760	l-serine dehydratase
M654_010880	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M654_010885	COG1349	DNA-binding transcription factor activity
M654_010890	COG0416	fatty acid biosynthetic process
M654_010895	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M654_010900	COG1028	Short-chain dehydrogenase reductase Sdr
M654_010905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M654_010910	COG0571	ribonuclease III activity
M654_010915	COG1196	nuclear chromosome segregation
M654_010920	COG0552	protein localization to endoplasmic reticulum
M654_010925	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M654_010930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M654_010935	COG0228	four-way junction DNA binding
M654_010940	COG1837	Belongs to the UPF0109 family
M654_010950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M654_010955	COG0336	Belongs to the RNA methyltransferase TrmD family
M654_010960	COG0335	large ribosomal subunit rRNA binding
M654_010965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M654_010970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M654_010980	COG2257	FlhB HrpN YscU SpaS Family
M654_010985	COG0045	succinate-CoA ligase (ADP-forming) activity
M654_010990	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M654_010995	COG0758	DNA mediated transformation
M654_011000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M654_011005	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M654_011010	COG4974	Belongs to the 'phage' integrase family
M654_011015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M654_011020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M654_011025	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M654_011030	COG1815	bacterial-type flagellum-dependent cell motility
M654_011035	COG1558	bacterial-type flagellum-dependent cell motility
M654_011040	COG1677	Flagellar hook-basal body complex protein FliE
M654_011045	COG1766	The M ring may be actively involved in energy transduction
M654_011050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M654_011055	COG1317	bacterial-type flagellum organization
M654_011060	COG1157	protein secretion by the type III secretion system
M654_011065	COG2882	bacterial-type flagellum organization
M654_011075	COG3144	bacterial-type flagellum assembly
M654_011080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M654_011085	COG4786	Flagellar basal body rod
M654_011090	COG1582	Flagellar protein (FlbD)
M654_011095	COG1580	Controls the rotational direction of flagella during chemotaxis
M654_011100	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M654_011105	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M654_011105	COG1776	CheC inhibitor of MCP methylation
M654_011110	COG2201	protein-glutamate methylesterase activity
M654_011115	COG3190	flagellar
M654_011120	COG1338	Plays a role in the flagellum-specific transport system
M654_011125	COG1987	bacterial-type flagellum assembly
M654_011130	COG1684	flagellar biosynthetic protein fliR
M654_011135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M654_011140	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M654_011145	COG1419	protein localization to endoplasmic reticulum
M654_011150	COG0455	bacterial-type flagellum organization
M654_011155	COG2201	protein-glutamate methylesterase activity
M654_011160	COG2198	Histidine kinase
M654_011160	COG0643	Histidine kinase
M654_011165	COG0835	chemotaxis
M654_011170	COG1776	CheC inhibitor of MCP methylation
M654_011175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M654_011180	COG1191	sigma factor activity
M654_011190	COG0052	Belongs to the universal ribosomal protein uS2 family
M654_011195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M654_011200	COG0528	UMP kinase activity
M654_011205	COG0233	cytoplasmic translational termination
M654_011210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M654_011215	COG4589	Belongs to the CDS family
M654_011220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M654_011225	COG0750	zinc metalloprotease
M654_011230	COG0442	prolyl-tRNA aminoacylation
M654_011235	COG2176	DNA-directed DNA polymerase activity
M654_011255	COG0779	Required for maturation of 30S ribosomal subunits
M654_011260	COG0195	Participates in both transcription termination and antitermination
M654_011265	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M654_011270	COG1358	cellular component organization or biogenesis
M654_011275	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M654_011280	COG1550	Protein conserved in bacteria
M654_011285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M654_011290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M654_011295	COG0196	riboflavin kinase activity
M654_011305	COG1185	polyribonucleotide nucleotidyltransferase activity
M654_011310	COG0726	polysaccharide deacetylase
M654_011315	COG0612	Peptidase, M16
M654_011320	COG1873	PFAM PRC-barrel domain
M654_011325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M654_011330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M654_011335	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M654_011340	COG0527	aspartate kinase activity
M654_011350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M654_011355	COG0740	serine-type endopeptidase activity
M654_011365	COG1674	ftsk spoiiie
M654_011365	COG4980	gas vesicle protein
M654_011370	COG2188	Transcriptional regulator
M654_011375	COG2814	Major facilitator Superfamily
M654_011380	COG0612	Peptidase, M16
M654_011385	COG0612	Peptidase, M16
M654_011390	COG0300	oxidoreductase activity
M654_011405	COG1426	Protein conserved in bacteria
M654_011410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M654_011415	COG1058	Belongs to the CinA family
M654_011415	COG1546	Belongs to the CinA family
M654_011425	COG1418	mRNA catabolic process
M654_011430	COG1692	metallophosphoesterase
M654_011435	COG2359	stage V sporulation protein S
M654_011445	COG1063	alcohol dehydrogenase
M654_011450	COG0156	8-amino-7-oxononanoate synthase activity
M654_011455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M654_011460	COG4550	Control of competence regulator ComK, YlbF/YmcA
M654_011470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M654_011475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M654_011515	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M654_011550	COG3620	sequence-specific DNA binding
M654_011570	COG1695	Transcriptional regulator
M654_011595	COG0747	negative chemotaxis
M654_011600	COG0601	transmembrane transport
M654_011605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M654_011610	COG0444	Belongs to the ABC transporter superfamily
M654_011615	COG1124	(ABC) transporter
M654_011630	COG1660	Displays ATPase and GTPase activities
M654_011635	COG1522	sequence-specific DNA binding
M654_011640	COG1902	pentaerythritol trinitrate reductase activity
M654_011670	COG0142	geranyltranstransferase activity
M654_011680	COG0457	Tetratricopeptide repeat
M654_011685	COG0402	S-adenosylhomocysteine deaminase activity
M654_011695	COG3619	membrane
M654_011705	COG2267	carboxylic ester hydrolase activity
M654_011715	COG0393	Putative heavy-metal-binding
M654_011720	COG0398	Pfam SNARE associated Golgi protein
M654_011725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M654_011730	COG1819	glycosyl
M654_011735	COG0531	amino acid
M654_011740	COG5577	PFAM Coat F domain
M654_011750	COG3858	chitin binding
M654_011750	COG1388	LysM domain
M654_011765	COG1764	response to oxidative stress
M654_011770	COG2076	Multidrug Resistance protein
M654_011775	COG2076	Multidrug Resistance protein
M654_011795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M654_011800	COG1923	regulation of RNA biosynthetic process
M654_011810	COG1780	Probably involved in ribonucleotide reductase function
M654_011815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M654_011820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M654_011825	COG4112	unkown
M654_011830	COG1802	Transcriptional regulator
M654_011835	COG0697	spore germination
M654_011855	COG4282	regulation of fungal-type cell wall biogenesis
M654_011860	COG5444	nuclease activity
M654_011870	COG2814	Major facilitator Superfamily
M654_011875	COG0457	Tetratricopeptide repeat
M654_011885	COG5444	nuclease activity
M654_011905	COG0457	Tetratricopeptide repeat
M654_011920	COG4413	Urea transporter
M654_011925	COG0831	urea catabolic process
M654_011930	COG0832	Belongs to the urease beta subunit family
M654_011940	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
M654_011945	COG0830	nickel cation binding
M654_011950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M654_011955	COG0829	nickel cation binding
M654_011965	COG1695	Transcriptional regulator
M654_011975	COG0464	growth
M654_011980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M654_011985	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M654_011990	COG0789	Transcriptional regulator
M654_011995	COG0174	glutamine synthetase
M654_012075	COG0582	viral genome integration into host DNA
M654_012130	COG4626	Terminase
M654_012130	COG1802	Transcriptional regulator
M654_012200	COG3942	CHAP domain
M654_012200	COG1705	Flagellar rod assembly protein muramidase FlgJ
M654_012205	COG5434	Belongs to the glycosyl hydrolase 28 family
M654_012240	COG5444	nuclease activity
M654_012295	COG3715	PTS system
M654_012300	COG3716	PTS system mannose fructose sorbose family IID component
M654_012310	COG0730	response to heat
M654_012320	COG2814	Major facilitator Superfamily
M654_012325	COG0457	Tetratricopeptide repeat
M654_012340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M654_012355	COG1073	alpha beta
M654_012380	COG0756	dUTP diphosphatase activity
M654_012390	COG1231	oxidoreductase activity
M654_012395	COG0457	Tetratricopeptide repeat
M654_012405	COG1309	transcriptional regulator
M654_012410	COG2076	Multidrug Resistance protein
M654_012415	COG2076	Multidrug Resistance protein
M654_012420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M654_012445	COG0456	acetyltransferase
M654_012485	COG5434	Belongs to the glycosyl hydrolase 28 family
M654_012490	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M654_012495	COG1388	LysM domain
M654_012500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M654_012505	COG4224	UPF0291 protein
M654_012510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M654_012520	COG3763	UPF0154 protein
M654_012530	COG0785	Cytochrome C biogenesis protein
M654_012535	COG2201	protein-glutamate methylesterase activity
M654_012540	COG4846	Membrane protein involved in cytochrome C biogenesis
M654_012550	COG0071	Belongs to the small heat shock protein (HSP20) family
M654_012565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M654_012590	COG0824	Thioesterase
M654_012600	COG4841	protein insertion into membrane
M654_012605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M654_012610	COG1832	CoA-binding protein
M654_012615	COG0187	DNA topoisomerase II activity
M654_012620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M654_012635	COG1115	amino acid carrier protein
M654_012645	COG2181	nitrate reductase activity
M654_012650	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M654_012655	COG1140	nitrate reductase beta subunit
M654_012660	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M654_012680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M654_012690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M654_012695	COG2223	nitrite transmembrane transporter activity
M654_012715	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M654_012725	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M654_012735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M654_012745	COG2814	Major facilitator Superfamily
M654_012755	COG0574	Belongs to the PEP-utilizing enzyme family
M654_012755	COG3848	Pyruvate phosphate dikinase
M654_012770	COG3420	alginic acid biosynthetic process
M654_012775	COG1114	Component of the transport system for branched-chain amino acids
M654_012800	COG1024	Enoyl-CoA hydratase
M654_012805	COG1012	belongs to the aldehyde dehydrogenase family
M654_012810	COG2084	Dehydrogenase
M654_012815	COG1960	acyl-CoA dehydrogenase activity
M654_012820	COG1482	cell wall glycoprotein biosynthetic process
M654_012825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M654_012825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_012825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M654_012830	COG3711	transcriptional antiterminator
M654_012830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_012845	COG1725	Transcriptional regulator
M654_012855	COG1309	transcriptional regulator
M654_012880	COG3507	Belongs to the glycosyl hydrolase 43 family
M654_012890	COG3118	belongs to the thioredoxin family
M654_012900	COG1132	(ABC) transporter
M654_012905	COG1132	(ABC) transporter
M654_012930	COG2084	Dehydrogenase
M654_012940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M654_012945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M654_012950	COG0640	Transcriptional regulator
M654_012955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M654_012970	COG1649	PFAM Uncharacterised BCR, COG1649
M654_012975	COG2404	hydrolase activity, acting on ester bonds
M654_012980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M654_012990	COG0297	glycogen (starch) synthase activity
M654_012995	COG2027	D-alanyl-D-alanine carboxypeptidase
M654_013015	COG2723	6-phospho-beta-galactosidase activity
M654_013025	COG2182	Extracellular solute-binding protein
M654_013030	COG0395	ABC-type sugar transport system, permease component
M654_013035	COG1175	transmembrane transport
M654_013045	COG1940	carbohydrate kinase activity
M654_013065	COG1309	transcriptional regulator
M654_013075	COG1252	NADH dehydrogenase
M654_013085	COG0166	Belongs to the GPI family
M654_013095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M654_013100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M654_013105	COG1024	Enoyl-CoA hydratase
M654_013110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M654_013115	COG0511	ligase activity, forming carbon-carbon bonds
M654_013120	COG0439	Biotin carboxylase
M654_013125	COG0318	PFAM AMP-dependent synthetase and ligase
M654_013130	COG1960	acyl-CoA dehydrogenase activity
M654_013135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M654_013140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M654_013150	COG2323	membrane
M654_013155	COG0529	Catalyzes the synthesis of activated sulfate
M654_013160	COG2046	Belongs to the sulfate adenylyltransferase family
M654_013165	COG0306	phosphate transporter
M654_013170	COG0175	sulfate reduction
M654_013175	COG1809	phosphosulfolactate synthase activity
M654_013180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M654_013185	COG4948	Mandelate Racemase Muconate Lactonizing
M654_013190	COG2814	Major facilitator Superfamily
M654_013195	COG0463	Glycosyl transferase, family 2
M654_013210	COG0493	'glutamate synthase
M654_013215	COG0070	glutamate synthase
M654_013215	COG0067	glutamate synthase
M654_013215	COG0069	glutamate synthase activity
M654_013220	COG0583	DNA-binding transcription factor activity
M654_013250	COG1132	(ABC) transporter
M654_013255	COG3540	Alkaline phosphatase
M654_013265	COG0300	oxidoreductase activity
M654_013270	COG0477	Major facilitator Superfamily
M654_013275	COG0243	molybdopterin cofactor binding
M654_013285	COG2814	Major facilitator Superfamily
M654_013290	COG0531	amino acid
M654_013300	COG0531	amino acid
M654_013305	COG0531	amino acid
M654_013310	COG0697	spore germination
M654_013330	COG0697	spore germination
M654_013345	COG0840	transmembrane signaling receptor activity
M654_013350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M654_013360	COG1404	Belongs to the peptidase S8 family
M654_013370	COG1309	transcriptional regulator
M654_013375	COG1846	Transcriptional regulator
M654_013405	COG1309	transcriptional regulator
M654_013410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_013415	COG3708	Transcriptional regulator
M654_013420	COG2378	regulation of single-species biofilm formation
M654_013430	COG0640	Transcriptional regulator
M654_013435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_013445	COG0531	amino acid
M654_013450	COG0741	lytic transglycosylase activity
M654_013455	COG1086	Polysaccharide biosynthesis protein
M654_013475	COG2322	membrane
M654_013490	COG1619	proteins homologs of microcin C7 resistance protein MccF
M654_013495	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M654_013500	COG3584	3D domain protein
M654_013500	COG1388	LysM domain
M654_013505	COG0514	ATP-dependent DNA helicase (RecQ)
M654_013565	COG0457	Tetratricopeptide repeat
M654_013580	COG5646	InterPro IPR014922
M654_013585	COG0346	lactoylglutathione lyase activity
M654_013590	COG0640	Transcriptional regulator
M654_013655	COG0477	Major facilitator Superfamily
M654_013660	COG2267	carboxylic ester hydrolase activity
M654_013665	COG1388	LysM domain
M654_013675	COG1280	lysine exporter protein (LysE YggA)
M654_013680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M654_013685	COG3848	Pyruvate phosphate dikinase
M654_013685	COG0574	Belongs to the PEP-utilizing enzyme family
M654_013695	COG1309	transcriptional regulator
M654_013730	COG2318	DinB family
M654_013735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M654_013740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M654_013755	COG1012	belongs to the aldehyde dehydrogenase family
M654_013765	COG0702	epimerase
M654_013770	COG2814	Major facilitator Superfamily
M654_013785	COG0667	Aldo Keto reductase
M654_013790	COG1657	PFAM Prenyltransferase squalene oxidase
M654_013795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M654_013810	COG0733	neurotransmitter:sodium symporter activity
M654_013815	COG0385	Bile acid
M654_013820	COG0508	dehydrogenase complex catalyzes the overall conversion of
M654_013825	COG0567	Dehydrogenase, E1 component
M654_013830	COG4548	von Willebrand factor, type A
M654_013835	COG0714	Associated with various cellular activities
M654_013840	COG2032	superoxide dismutase activity
M654_013845	COG1388	LysM domain
M654_013845	COG0791	NLP P60 protein
M654_013850	COG0534	Mate efflux family protein
M654_013855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M654_013860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M654_013870	COG2962	Rard protein
M654_013880	COG4305	rare lipoprotein A
M654_013895	COG1733	regulation of RNA biosynthetic process
M654_013900	COG0778	Nitroreductase
M654_013905	COG0400	carboxylic ester hydrolase activity
M654_013910	COG0346	lactoylglutathione lyase activity
M654_013920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M654_013925	COG0793	Belongs to the peptidase S41A family
M654_013925	COG3409	Peptidoglycan-binding domain 1 protein
M654_013930	COG2226	methyltransferase
M654_013940	COG1876	peptidase activity
M654_013945	COG0813	purine-nucleoside phosphorylase activity
M654_013950	COG0701	Predicted permease
M654_013970	COG0671	phosphoesterase, PA-phosphatase related
M654_013985	COG4479	Belongs to the UPF0346 family
M654_013995	COG1509	lysine 2,3-aminomutase activity
M654_014000	COG0456	acetyltransferase
M654_014005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M654_014010	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M654_014015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M654_014020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M654_014035	COG0456	acetyltransferase
M654_014040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M654_014045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M654_014050	COG1846	Transcriptional regulator
M654_014060	COG0534	Mate efflux family protein
M654_014075	COG4698	Protein conserved in bacteria
M654_014080	COG2755	lipolytic protein G-D-S-L family
M654_014085	COG1999	signal sequence binding
M654_014100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M654_014105	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M654_014110	COG1272	protein, Hemolysin III
M654_014115	COG0204	Acyl-transferase
M654_014120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M654_014125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M654_014140	COG2521	methyltransferase
M654_014140	COG2136	Putative SAM-dependent methyltransferase
M654_014150	COG0129	dihydroxy-acid dehydratase activity
M654_014155	COG1413	lyase activity
M654_014160	COG1418	mRNA catabolic process
M654_014165	COG0386	Belongs to the glutathione peroxidase family
M654_014170	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M654_014175	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M654_014180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M654_014190	COG1278	Cold shock
M654_014210	COG0328	RNA-DNA hybrid ribonuclease activity
M654_014215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M654_014220	COG0328	RNA-DNA hybrid ribonuclease activity
M654_014230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M654_014240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M654_014250	COG1755	Isoprenylcysteine carboxyl methyltransferase
M654_014255	COG3424	synthase
M654_014265	COG2233	PERMEase
M654_014270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M654_014275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M654_014280	COG1199	ATP-dependent helicase activity
M654_014290	COG0116	Belongs to the methyltransferase superfamily
M654_014300	COG3599	regulation of cell shape
M654_014305	COG4474	Belongs to the UPF0398 family
M654_014315	COG3359	exonuclease
M654_014320	COG1111	helicase
M654_014320	COG1205	dead DEAH box helicase
M654_014325	COG2190	(PTS) system
M654_014330	COG0071	Belongs to the small heat shock protein (HSP20) family
M654_014365	COG3331	DNA recombination
M654_014370	COG4499	WXG100 protein secretion system (Wss), protein YukC
M654_014370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M654_014380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M654_014385	COG3935	DnaD domain protein
M654_014390	COG0017	Asparaginyl-tRNA synthetase
M654_014395	COG0436	Aminotransferase
M654_014400	COG5353	protein conserved in bacteria
M654_014410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M654_014410	COG1199	ATP-dependent helicase activity
M654_014415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M654_014420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M654_014425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M654_014435	COG0617	tRNA 3'-terminal CCA addition
M654_014440	COG0438	transferase activity, transferring glycosyl groups
M654_014445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M654_014450	COG1803	Methylglyoxal synthase
M654_014455	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M654_014460	COG1694	Mazg nucleotide pyrophosphohydrolase
M654_014465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M654_014475	COG4347	Protein of unknown function (DUF1405)
M654_014480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M654_014480	COG2010	Cytochrome c
M654_014485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M654_014490	COG0723	plastoquinol--plastocyanin reductase activity
M654_014500	COG5582	Belongs to the UPF0302 family
M654_014505	COG0457	Tetratricopeptide repeat
M654_014510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M654_014515	COG0287	Prephenate dehydrogenase
M654_014520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M654_014525	COG0159	tryptophan synthase activity
M654_014530	COG0133	tryptophan synthase activity
M654_014535	COG0135	phosphoribosylanthranilate isomerase activity
M654_014540	COG0134	indole-3-glycerol-phosphate synthase activity
M654_014545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M654_014550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M654_014555	COG4401	Chorismate mutase type I
M654_014560	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M654_014565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M654_014570	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M654_014575	COG0105	UTP biosynthetic process
M654_014580	COG0142	geranyltranstransferase activity
M654_014585	COG2226	methyltransferase
M654_014590	COG0142	geranyltranstransferase activity
M654_014600	COG0302	gtp cyclohydrolase
M654_014605	COG0776	regulation of translation
M654_014610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M654_014625	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M654_014630	COG1160	GTP binding
M654_014655	COG1304	FMN binding
M654_014660	COG0539	negative regulation of cytoplasmic translation
M654_014665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M654_014675	COG2959	enzyme of heme biosynthesis
M654_014680	COG3773	Cell wall hydrolase
M654_014680	COG3409	Peptidoglycan-binding domain 1 protein
M654_014685	COG2339	peptidase activity
M654_014695	COG0492	ferredoxin-NADP+ reductase activity
M654_014700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M654_014705	COG4862	establishment of competence for transformation
M654_014710	COG1408	metallophosphoesterase
M654_014720	COG1388	LysM domain
M654_014725	COG1266	CAAX protease self-immunity
M654_014730	COG0514	ATP-dependent DNA helicase (RecQ)
M654_014735	COG4955	Helix-turn-helix domain
M654_014740	COG1141	Ferredoxin
M654_014745	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M654_014750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M654_014755	COG0739	heme binding
M654_014765	COG1595	DNA-templated transcription, initiation
M654_014770	COG1316	TRANSCRIPTIONal
M654_014775	COG0726	polysaccharide deacetylase
M654_014785	COG5002	protein histidine kinase activity
M654_014790	COG0745	RESPONSE REGULATOR receiver
M654_014795	COG5002	protein histidine kinase activity
M654_014800	COG0745	RESPONSE REGULATOR receiver
M654_014805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M654_014810	COG1333	cytochrome c biogenesis protein
M654_014815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M654_014820	COG1187	pseudouridine synthase activity
M654_014825	COG0700	Nucleoside recognition
M654_014830	COG2715	membrane protein required for spore maturation
M654_014835	COG1686	Belongs to the peptidase S11 family
M654_014845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M654_014850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M654_014860	COG1547	Domain of unknown function (DUF309)
M654_014865	COG0456	acetyltransferase
M654_014870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M654_014875	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M654_014875	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M654_014880	COG0307	riboflavin synthase, alpha
M654_014885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M654_014885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M654_014900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M654_014910	COG4086	secreted protein
M654_014915	COG4195	phage-related replication protein
M654_014920	COG0019	diaminopimelate decarboxylase activity
M654_014930	COG0697	spore germination
M654_014945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M654_014980	COG1686	Belongs to the peptidase S11 family
M654_014990	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M654_014995	COG4974	Belongs to the 'phage' integrase family
M654_015005	COG0735	belongs to the Fur family
M654_015010	COG1300	Membrane
M654_015015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_015020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_015025	COG1953	Uracil, thiamine, allantoin
M654_015050	COG2153	protein acetylation
M654_015055	COG1379	DNA repair
M654_015060	COG0494	nUDIX hydrolase
M654_015070	COG1309	transcriptional regulator
M654_015080	COG0667	Aldo Keto reductase
M654_015090	COG1073	alpha beta
M654_015100	COG4918	Iron-sulphur cluster biosynthesis
M654_015110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M654_015110	COG0456	acetyltransferase
M654_015115	COG2329	Antibiotic biosynthesis monooxygenase
M654_015120	COG0456	acetyltransferase
M654_015125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M654_015135	COG0747	negative chemotaxis
M654_015140	COG0601	transmembrane transport
M654_015145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M654_015150	COG0444	Belongs to the ABC transporter superfamily
M654_015160	COG0534	Mate efflux family protein
M654_015175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M654_015190	COG2211	Major facilitator Superfamily
M654_015195	COG0346	lactoylglutathione lyase activity
M654_015200	COG1072	(Pantothenic acid kinase))
M654_015210	COG1126	abc transporter atp-binding protein
M654_015235	COG5002	protein histidine kinase activity
M654_015240	COG0745	RESPONSE REGULATOR receiver
M654_015250	COG4195	phage-related replication protein
M654_015255	COG0300	oxidoreductase activity
M654_015260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_015265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M654_015270	COG4187	Peptidase family M20/M25/M40
M654_015275	COG1902	pentaerythritol trinitrate reductase activity
M654_015280	COG0596	Alpha beta hydrolase
M654_015285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M654_015290	COG1234	tRNA 3'-trailer cleavage
M654_015295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M654_015310	COG2358	TRAP transporter, solute receptor (TAXI family
M654_015320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M654_015330	COG0446	pyridine nucleotide-disulphide oxidoreductase
M654_015330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M654_015340	COG1114	Component of the transport system for branched-chain amino acids
M654_015350	COG2188	Transcriptional regulator
M654_015355	COG2723	6-phospho-beta-galactosidase activity
M654_015360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_015365	COG1447	Phosphotransferase system cellobiose-specific component IIA
M654_015370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_015375	COG1785	Belongs to the alkaline phosphatase family
M654_015380	COG1028	Short-chain dehydrogenase reductase Sdr
M654_015385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M654_015390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M654_015400	COG0706	membrane insertase activity
M654_015405	COG2195	Cleaves the N-terminal amino acid of tripeptides
M654_015410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M654_015420	COG4129	membrane
M654_015425	COG1126	abc transporter atp-binding protein
M654_015430	COG0765	amino acid transport
M654_015435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M654_015445	COG1597	lipid kinase activity
M654_015450	COG0508	dehydrogenase complex catalyzes the overall conversion of
M654_015455	COG0022	dehydrogenase e1 component
M654_015460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M654_015465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M654_015470	COG3426	butyrate kinase activity
M654_015480	COG0280	phosphate acetyltransferase
M654_015485	COG3290	protein histidine kinase activity
M654_015485	COG3829	transcription factor binding
M654_015495	COG0584	glycerophosphoryl diester phosphodiesterase
M654_015500	COG0860	N-Acetylmuramoyl-L-alanine amidase
M654_015515	COG0745	RESPONSE REGULATOR receiver
M654_015520	COG0750	zinc metalloprotease
M654_015525	COG0497	DNA recombination
M654_015530	COG1438	arginine binding
M654_015535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M654_015540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M654_015545	COG0142	geranyltranstransferase activity
M654_015550	COG1722	exodeoxyribonuclease VII activity
M654_015555	COG1570	exodeoxyribonuclease VII activity
M654_015560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M654_015565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M654_015570	COG1302	Protein conserved in bacteria
M654_015575	COG0439	Biotin carboxylase
M654_015580	COG0511	ligase activity, forming carbon-carbon bonds
M654_015620	COG3854	ATPases associated with a variety of cellular activities
M654_015630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M654_015635	COG0006	proline dipeptidase activity
M654_015640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M654_015650	COG3872	metal-dependent enzyme
M654_015660	COG1752	Esterase of the alpha-beta hydrolase superfamily
M654_015665	COG1321	iron dependent repressor
M654_015670	COG0095	Lipoate-protein ligase
M654_015675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M654_015680	COG2113	Glycine betaine
M654_015685	COG4176	ABC-type proline glycine betaine transport system permease component
M654_015690	COG0517	IMP dehydrogenase activity
M654_015690	COG4175	Glycine betaine
M654_015695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M654_015700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M654_015705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M654_015710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M654_015735	COG0681	Belongs to the peptidase S26 family
M654_015760	COG4940	Competence protein ComGF
M654_015770	COG4970	Tfp pilus assembly protein FimT
M654_015775	COG4537	Required for transformation and DNA binding
M654_015780	COG1459	type II secretion system
M654_015785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M654_015790	COG1366	Belongs to the anti-sigma-factor antagonist family
M654_015800	COG1393	Belongs to the ArsC family
M654_015810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_015820	COG0011	TIGRFAM Protein of
M654_015830	COG2866	Carboxypeptidase
M654_015850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_015855	COG1368	sulfuric ester hydrolase activity
M654_015860	COG1940	carbohydrate kinase activity
M654_015865	COG4483	Protein conserved in bacteria
M654_015870	COG0697	spore germination
M654_015875	COG0457	Tetratricopeptide repeat
M654_015875	COG0705	Rhomboid family
M654_015880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M654_015885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M654_015890	COG0438	transferase activity, transferring glycosyl groups
M654_015905	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M654_015910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M654_015915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M654_015920	COG0581	inorganic phosphate transmembrane transporter activity
M654_015925	COG0573	inorganic phosphate transmembrane transporter activity
M654_015930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M654_015940	COG0477	Major facilitator Superfamily
M654_015945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M654_015950	COG2839	Protein conserved in bacteria
M654_015955	COG5521	maltodextrose utilization protein MalA
M654_015960	COG1388	LysM domain
M654_015965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M654_015970	COG4709	membrane
M654_015975	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M654_015980	COG0735	belongs to the Fur family
M654_015985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M654_015990	COG1121	(ABC) transporter
M654_015995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M654_016005	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M654_016010	COG0513	Belongs to the DEAD box helicase family
M654_016020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M654_016030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M654_016035	COG2384	SAM-dependent methyltransferase
M654_016040	COG2010	Cytochrome c
M654_016045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M654_016050	COG0358	DNA primase activity
M654_016055	COG1671	Belongs to the UPF0178 family
M654_016060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M654_016065	COG0517	IMP dehydrogenase activity
M654_016070	COG0751	glycine-tRNA ligase activity
M654_016075	COG0752	glycyl-tRNA synthetase alpha subunit
M654_016080	COG1381	Involved in DNA repair and RecF pathway recombination
M654_016090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M654_016095	COG0295	cytidine deaminase activity
M654_016100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M654_016105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M654_016110	COG1480	7TM receptor with intracellular HD hydrolase
M654_016115	COG1702	phosphate starvation-inducible protein PhoH
M654_016120	COG0561	phosphatase activity
M654_016135	COG4864	UPF0365 protein
M654_016140	COG1030	water channel activity
M654_016145	COG1610	YqeY-like protein
M654_016150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M654_016155	COG1283	sodium-dependent phosphate transmembrane transporter activity
M654_016160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M654_016165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M654_016170	COG2264	protein methyltransferase activity
M654_016175	COG0484	heat shock protein binding
M654_016180	COG0443	Heat shock 70 kDa protein
M654_016185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M654_016190	COG1420	regulation of RNA biosynthetic process
M654_016195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M654_016200	COG0481	GTPase activity
M654_016210	COG0860	N-Acetylmuramoyl-L-alanine amidase
M654_016215	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M654_016220	COG0268	Binds directly to 16S ribosomal RNA
M654_016230	COG1466	dna polymerase III delta subunit
M654_016240	COG0658	competence protein
M654_016240	COG2333	competence protein COMEC
M654_016245	COG2131	deaminase
M654_016250	COG1555	photosystem II stabilization
M654_016250	COG1596	polysaccharide export
M654_016255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M654_016260	COG2226	methyltransferase
M654_016265	COG0799	negative regulation of ribosome biogenesis
M654_016270	COG1713	HD superfamily hydrolase involved in NAD metabolism
M654_016275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M654_016280	COG1534	Rna-binding protein
M654_016285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M654_016290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M654_016295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M654_016305	COG2755	lipolytic protein G-D-S-L family
M654_016315	COG5609	conserved protein (DUF2294)
M654_016320	COG3383	formate dehydrogenase (NAD+) activity
M654_016325	COG2427	Protein of unknown function (DUF1641)
M654_016345	COG1247	-acetyltransferase
M654_016385	COG2808	Putative FMN-binding domain
M654_016390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M654_016410	COG0251	oxidation-reduction process
M654_016420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M654_016425	COG0251	oxidation-reduction process
M654_016470	COG2315	Protein conserved in bacteria
M654_016480	COG0789	Transcriptional regulator
M654_016480	COG4978	Transcriptional regulator
M654_016495	COG1785	Belongs to the alkaline phosphatase family
M654_016500	COG0747	negative chemotaxis
M654_016505	COG0601	transmembrane transport
M654_016510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M654_016515	COG0444	Belongs to the ABC transporter superfamily
M654_016520	COG4608	Belongs to the ABC transporter superfamily
M654_016525	COG3239	Fatty acid desaturase
M654_016530	COG4585	Histidine kinase
M654_016535	COG2197	response regulator
M654_016540	COG0492	ferredoxin-NADP+ reductase activity
M654_016550	COG0523	cobalamin synthesis protein
M654_016555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_016560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M654_016565	COG0113	porphobilinogen synthase activity
M654_016570	COG0822	iron-sulfur transferase activity
M654_016575	COG0803	Belongs to the bacterial solute-binding protein 9 family
M654_016580	COG1121	(ABC) transporter
M654_016585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M654_016590	COG1942	4-Oxalocrotonate Tautomerase
M654_016605	COG1028	Short-chain dehydrogenase reductase Sdr
M654_016610	COG1525	nuclease
M654_016630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M654_016640	COG0730	response to heat
M654_016655	COG2197	response regulator
M654_016660	COG4585	Histidine kinase
M654_016680	COG2124	cytochrome p450
M654_016685	COG3507	Belongs to the glycosyl hydrolase 43 family
M654_016690	COG2211	Major facilitator Superfamily
M654_016695	COG1028	Short-chain dehydrogenase reductase Sdr
M654_016700	COG1621	beta-fructofuranosidase activity
M654_016705	COG3716	PTS system mannose fructose sorbose family IID component
M654_016710	COG3715	PTS system
M654_016715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_016720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_016725	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M654_016725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M654_016750	COG2814	Major facilitator Superfamily
M654_016760	COG2350	Protein conserved in bacteria
M654_016775	COG2169	Transcriptional regulator
M654_016780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M654_016785	COG2205	protein histidine kinase activity
M654_016810	COG0656	L-ascorbic acid biosynthetic process
M654_016815	COG2814	Major facilitator Superfamily
M654_016820	COG1733	regulation of RNA biosynthetic process
M654_016825	COG3340	Belongs to the peptidase S51 family
M654_016830	COG1587	Uroporphyrinogen-III synthase
M654_016840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M654_016870	COG2814	Major facilitator Superfamily
M654_016875	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M654_016875	COG2124	cytochrome p450
M654_016880	COG1309	transcriptional regulator
M654_016885	COG2226	methyltransferase
M654_016905	COG0626	cystathionine gamma-synthase activity
M654_016910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M654_016915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M654_016920	COG2226	methyltransferase
M654_016935	COG0768	penicillin binding
M654_016940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M654_016945	COG0572	uridine kinase
M654_016960	COG4122	O-methyltransferase activity
M654_016965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M654_016970	COG3906	Belongs to the UPF0473 family
M654_016975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M654_016980	COG4472	Bacterial protein of unknown function (DUF965)
M654_016985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M654_016990	COG0628	permease
M654_017005	COG3881	PFAM PRC-barrel domain
M654_017010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M654_017015	COG0457	Tetratricopeptide repeat
M654_017020	COG0482	sulfurtransferase activity
M654_017025	COG1104	cysteine desulfurase activity
M654_017030	COG1959	2 iron, 2 sulfur cluster binding
M654_017035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M654_017040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M654_017050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M654_017055	COG0124	histidyl-tRNA synthetase
M654_017065	COG4991	sh3 domain protein
M654_017065	COG3103	Sh3 type 3 domain protein
M654_017065	COG0860	N-Acetylmuramoyl-L-alanine amidase
M654_017070	COG1490	D-aminoacyl-tRNA deacylase activity
M654_017075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M654_017080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M654_017085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M654_017085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M654_017090	COG5416	Lipopolysaccharide assembly protein A domain
M654_017095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M654_017095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M654_017105	COG2244	polysaccharide biosynthetic process
M654_017110	COG2323	membrane
M654_017120	COG1862	Preprotein translocase
M654_017125	COG0343	queuine tRNA-ribosyltransferase activity
M654_017130	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M654_017140	COG2255	four-way junction helicase activity
M654_017145	COG0632	four-way junction helicase activity
M654_017155	COG2112	serine threonine protein kinase
M654_017165	COG2318	DinB family
M654_017170	COG4195	phage-related replication protein
M654_017185	COG0217	transcriptional regulatory protein
M654_017195	COG1388	LysM domain
M654_017200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M654_017205	COG0157	Belongs to the NadC ModD family
M654_017210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M654_017215	COG1104	cysteine desulfurase activity
M654_017220	COG1827	regulation of RNA biosynthetic process
M654_017225	COG0077	Prephenate dehydratase
M654_017230	COG4492	Belongs to the UPF0735 family
M654_017235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M654_017240	COG3290	protein histidine kinase activity
M654_017245	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M654_017250	COG2868	ribosomal protein
M654_017255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M654_017260	COG1994	Peptidase M50
M654_017265	COG0739	heme binding
M654_017270	COG3832	glyoxalase III activity
M654_017275	COG0640	Transcriptional regulator
M654_017280	COG2894	cell division
M654_017285	COG0850	regulation of cytokinetic process
M654_017290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M654_017300	COG1077	Cell shape determining protein MreB Mrl
M654_017305	COG2003	Belongs to the UPF0758 family
M654_017310	COG0424	maF-like protein
M654_017320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M654_017325	COG0285	dihydrofolate synthase activity
M654_017330	COG0525	valine-tRNA ligase activity
M654_017340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M654_017345	COG1388	LysM domain
M654_017350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M654_017355	COG0113	porphobilinogen synthase activity
M654_017360	COG1587	Uroporphyrinogen-III synthase
M654_017365	COG0181	hydroxymethylbilane synthase activity
M654_017370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M654_017375	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M654_017385	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M654_017390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M654_017395	COG1067	ATP-dependent peptidase activity
M654_017395	COG0470	DNA polymerase III
M654_017400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M654_017405	COG0544	peptidyl-prolyl cis-trans isomerase activity
M654_017410	COG0457	Tetratricopeptide repeat
M654_017410	COG1477	protein flavinylation
M654_017415	COG0066	3-isopropylmalate dehydratase activity
M654_017420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M654_017425	COG0473	3-isopropylmalate dehydrogenase activity
M654_017430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M654_017435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M654_017440	COG0440	acetolactate synthase activity
M654_017445	COG0028	Belongs to the TPP enzyme family
M654_017450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M654_017460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M654_017485	COG0622	Phosphoesterase
M654_017490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M654_017495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M654_017500	COG5401	PFAM Sporulation and spore germination
M654_017505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M654_017510	COG1846	Transcriptional regulator
M654_017515	COG2197	response regulator
M654_017520	COG0300	oxidoreductase activity
M654_017525	COG0824	Thioesterase
M654_017530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M654_017535	COG1053	succinate dehydrogenase
M654_017540	COG2009	succinate dehydrogenase
M654_017545	COG1719	4-vinyl reductase, 4VR
M654_017555	COG0527	aspartate kinase activity
M654_017560	COG0322	excinuclease ABC activity
M654_017565	COG3118	belongs to the thioredoxin family
M654_017570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M654_017575	COG2086	electron transfer activity
M654_017580	COG1024	Enoyl-CoA hydratase
M654_017585	COG1309	transcriptional regulator
M654_017590	COG0318	PFAM AMP-dependent synthetase and ligase
M654_017595	COG3766	membrane
M654_017600	COG1193	negative regulation of DNA recombination
M654_017605	COG1796	DNA polymerase
M654_017605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M654_017610	COG1286	toxin biosynthetic process
M654_017615	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M654_017620	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M654_017635	COG0072	phenylalanine-tRNA ligase activity
M654_017635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M654_017640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M654_017645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M654_017655	COG1966	Carbon starvation protein
M654_017665	COG3402	PFAM membrane-flanked domain
M654_017685	COG0395	ABC-type sugar transport system, permease component
M654_017690	COG1175	transmembrane transport
M654_017695	COG1653	transport
M654_017700	COG0371	Dehydrogenase
M654_017705	COG0235	Class ii aldolase
M654_017710	COG1069	ribulokinase activity
M654_017715	COG2160	L-arabinose isomerase activity
M654_017720	COG3507	Belongs to the glycosyl hydrolase 43 family
M654_017725	COG1363	Peptidase, m42
M654_017735	COG3326	Membrane
M654_017740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M654_017745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M654_017750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M654_017755	COG3540	Alkaline phosphatase
M654_017760	COG1011	Hydrolase
M654_017765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M654_017775	COG0398	Pfam SNARE associated Golgi protein
M654_017780	COG1484	DNA-dependent DNA replication
M654_017785	COG3611	Membrane attachment protein
M654_017790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M654_017800	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M654_017805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M654_017810	COG3866	Pectate lyase
M654_017815	COG0237	dephospho-CoA kinase activity
M654_017820	COG1971	Probably functions as a manganese efflux pump
M654_017825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M654_017830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M654_017830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M654_017835	COG5002	protein histidine kinase activity
M654_017840	COG0745	RESPONSE REGULATOR receiver
M654_017845	COG0039	L-malate dehydrogenase activity
M654_017850	COG0538	isocitrate dehydrogenase activity
M654_017855	COG0372	Belongs to the citrate synthase family
M654_017860	COG2707	UPF0756 membrane protein
M654_017865	COG0628	permease
M654_017870	COG3030	protein affecting phage T7 exclusion by the F plasmid
M654_017880	COG0205	6-phosphofructokinase activity
M654_017885	COG0825	malonyl-CoA metabolic process
M654_017890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M654_017895	COG0281	malic enzyme
M654_017900	COG0587	DNA-directed DNA polymerase activity
M654_017920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M654_017930	COG4109	DRTGG domain
M654_017935	COG1695	Transcriptional regulator
M654_017945	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M654_017950	COG1028	Short-chain dehydrogenase reductase Sdr
M654_017955	COG0165	Argininosuccinate lyase
M654_017960	COG0137	argininosuccinate synthase activity
M654_017965	COG0521	Mo-molybdopterin cofactor biosynthetic process
M654_017970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M654_017975	COG0827	DNA restriction-modification system
M654_017980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M654_017985	COG3874	Sporulation protein YtfJ
M654_017995	COG1714	RDD family
M654_018000	COG0616	signal peptide processing
M654_018005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M654_018010	COG1566	PFAM secretion protein HlyD family protein
M654_018015	COG0477	Major facilitator Superfamily
M654_018020	COG1846	Transcriptional regulator
M654_018025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M654_018035	COG0301	tRNA thio-modification
M654_018040	COG1104	cysteine desulfurase activity
M654_018045	COG1114	Component of the transport system for branched-chain amino acids
M654_018050	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M654_018055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M654_018060	COG1309	transcriptional regulator
M654_018065	COG1956	GAF domain-containing protein
M654_018070	COG2199	diguanylate cyclase activity
M654_018070	COG2203	Gaf domain
M654_018075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M654_018090	COG1522	sequence-specific DNA binding
M654_018095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M654_018100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M654_018105	COG0454	-acetyltransferase
M654_018110	COG0517	IMP dehydrogenase activity
M654_018115	COG0123	including yeast histone deacetylase and acetoin utilization protein
M654_018120	COG1360	Flagellar Motor Protein
M654_018125	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M654_018130	COG1609	Transcriptional regulator
M654_018135	COG1605	Chorismate mutase
M654_018135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M654_018145	COG3118	belongs to the thioredoxin family
M654_018150	COG4980	gas vesicle protein
M654_018155	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M654_018160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M654_018165	COG1674	ftsk spoiiie
M654_018170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M654_018175	COG4848	Belongs to the UPF0354 family
M654_018180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M654_018190	COG1363	Peptidase, m42
M654_018195	COG5584	Small secreted protein
M654_018200	COG0281	malic enzyme
M654_018205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_018210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M654_018220	COG0510	thiamine kinase activity
M654_018225	COG1523	belongs to the glycosyl hydrolase 13 family
M654_018230	COG1597	lipid kinase activity
M654_018240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M654_018245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M654_018255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M654_018260	COG2252	PERMEase
M654_018265	COG4473	ABC transporter
M654_018270	COG1131	(ABC) transporter
M654_018275	COG1349	DNA-binding transcription factor activity
M654_018280	COG1187	pseudouridine synthase activity
M654_018285	COG2244	polysaccharide biosynthetic process
M654_018290	COG2081	HI0933 family
M654_018295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M654_018310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M654_018315	COG0457	Tetratricopeptide repeat
M654_018325	COG5578	integral membrane protein
M654_018330	COG0673	inositol 2-dehydrogenase activity
M654_018335	COG1653	transport
M654_018340	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M654_018345	COG4209	transmembrane transport
M654_018350	COG2207	Transcriptional regulator
M654_018355	COG1653	transport
M654_018360	COG0395	ABC-type sugar transport system, permease component
M654_018365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M654_018370	COG1073	alpha beta
M654_018380	COG0583	DNA-binding transcription factor activity
M654_018385	COG0346	lactoylglutathione lyase activity
M654_018390	COG0495	leucyl-tRNA aminoacylation
M654_018400	COG2814	Major facilitator Superfamily
M654_018410	COG2433	Pfam Transposase IS66
M654_018415	COG0577	efflux transmembrane transporter activity
M654_018420	COG1136	(ABC) transporter
M654_018435	COG2197	response regulator
M654_018445	COG0577	efflux transmembrane transporter activity
M654_018450	COG1136	(ABC) transporter
M654_018460	COG1131	(ABC) transporter
M654_018465	COG1725	Transcriptional regulator
M654_018505	COG0577	efflux transmembrane transporter activity
M654_018510	COG1136	(ABC) transporter
M654_018535	COG1242	4 iron, 4 sulfur cluster binding
M654_018540	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M654_018550	COG2267	carboxylic ester hydrolase activity
M654_018555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M654_018560	COG0671	phosphoesterase, PA-phosphatase related
M654_018565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M654_018565	COG0438	transferase activity, transferring glycosyl groups
M654_018570	COG0367	asparagine synthase
M654_018575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M654_018580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M654_018595	COG1506	peptidase
M654_018600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M654_018605	COG1116	anion transmembrane transporter activity
M654_018610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M654_018615	COG0494	nUDIX hydrolase
M654_018625	COG4824	toxin secretion phage lysis holin
M654_018630	COG0783	Belongs to the Dps family
M654_018645	COG1854	S-ribosylhomocysteine lyase activity
M654_018650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M654_018655	COG0288	reversible hydration of carbon dioxide
M654_018660	COG0803	Belongs to the bacterial solute-binding protein 9 family
M654_018665	COG0254	rRNA binding
M654_018670	COG1271	oxidase subunit
M654_018675	COG1294	oxidase, subunit
M654_018685	COG4948	Mandelate Racemase Muconate Lactonizing
M654_018690	COG0318	PFAM AMP-dependent synthetase and ligase
M654_018695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M654_018700	COG0596	Alpha beta hydrolase
M654_018705	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M654_018710	COG1169	isochorismate synthase
M654_018715	COG1575	Belongs to the MenA family. Type 1 subfamily
M654_018720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M654_018725	COG0058	SHG alpha-glucan phosphorylase activity
M654_018730	COG0297	glycogen (starch) synthase activity
M654_018735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M654_018740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M654_018745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M654_018855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M654_018915	COG0735	belongs to the Fur family
M654_018920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M654_018925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M654_018930	COG4129	membrane
M654_018945	COG0747	negative chemotaxis
M654_018950	COG4608	Belongs to the ABC transporter superfamily
M654_018955	COG0444	Belongs to the ABC transporter superfamily
M654_018960	COG1132	(ABC) transporter
M654_018965	COG3557	Belongs to the UPF0374 family
M654_018980	COG1028	Short-chain dehydrogenase reductase Sdr
M654_018990	COG1194	a g-specific adenine glycosylase
M654_018995	COG1988	membrane-bound metal-dependent
M654_019000	COG4485	Bacterial membrane protein, YfhO
M654_019010	COG0463	Glycosyl transferase, family 2
M654_019015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M654_019040	COG2137	regulation of response to DNA damage stimulus
M654_019045	COG1090	epimerase
M654_019065	COG0778	Nitroreductase
M654_019070	COG0384	phenazine biosynthesis protein PhzF
M654_019075	COG0392	lysyltransferase activity
M654_019075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M654_019085	COG1051	belongs to the nudix hydrolase family
M654_019095	COG1653	transport
M654_019105	COG3507	Belongs to the glycosyl hydrolase 43 family
M654_019115	COG2514	catechol 2,3-dioxygenase activity
M654_019120	COG2259	Doxx family
M654_019125	COG1733	regulation of RNA biosynthetic process
M654_019135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_019135	COG1263	PTS System
M654_019140	COG1737	Transcriptional regulator
M654_019145	COG1486	melibiose metabolic process
M654_019150	COG1742	UPF0060 membrane protein
M654_019155	COG3284	Transcriptional regulator
M654_019160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M654_019165	COG0508	dehydrogenase complex catalyzes the overall conversion of
M654_019170	COG0022	dehydrogenase e1 component
M654_019175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M654_019185	COG5609	conserved protein (DUF2294)
M654_019190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M654_019195	COG3002	Belongs to the UPF0753 family
M654_019205	COG3711	transcriptional antiterminator
M654_019210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_019210	COG1263	PTS System
M654_019220	COG0477	Major facilitator Superfamily
M654_019240	COG4637	Psort location Cytoplasmic, score
M654_019245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M654_019250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M654_019255	COG0598	Magnesium transport protein CorA
M654_019265	COG0371	Dehydrogenase
M654_019270	COG0726	polysaccharide deacetylase
M654_019280	COG0535	radical SAM domain protein
M654_019290	COG0387	Pfam Sodium calcium exchanger
M654_019300	COG0477	Major facilitator Superfamily
M654_019305	COG1295	ribonuclease BN
M654_019310	COG4980	gas vesicle protein
M654_019315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M654_019320	COG1115	amino acid carrier protein
M654_019325	COG4840	Belongs to the UPF0435 family
M654_019330	COG0693	protein deglycase activity
M654_019335	COG0737	Belongs to the 5'-nucleotidase family
M654_019340	COG0778	Nitroreductase
M654_019345	COG1733	regulation of RNA biosynthetic process
M654_019355	COG1309	transcriptional regulator
M654_019360	COG2076	Multidrug Resistance protein
M654_019375	COG0673	inositol 2-dehydrogenase activity
M654_019390	COG1216	Glycosyl transferase, family 2
M654_019390	COG0463	Glycosyl transferase, family 2
M654_019395	COG0438	transferase activity, transferring glycosyl groups
M654_019400	COG0730	response to heat
M654_019405	COG0463	Glycosyl transferase, family 2
M654_019405	COG0457	Tetratricopeptide repeat
M654_019410	COG1215	transferase activity, transferring glycosyl groups
M654_019430	COG2188	Transcriptional regulator
M654_019435	COG0366	Alpha amylase catalytic
M654_019440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_019440	COG1263	PTS System
M654_019450	COG1115	amino acid carrier protein
M654_019460	COG1368	sulfuric ester hydrolase activity
M654_019465	COG0024	Methionine aminopeptidase
M654_019475	COG2258	MOSC domain
M654_019480	COG1254	Belongs to the acylphosphatase family
M654_019485	COG0640	Transcriptional regulator
M654_019490	COG5658	integral membrane protein
M654_019495	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M654_019505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_019510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_019520	COG0471	metal ion transport
M654_019535	COG2130	NADP-dependent
M654_019540	COG0513	Belongs to the DEAD box helicase family
M654_019545	COG0488	(ABC) transporter
M654_019550	COG2814	Major facilitator Superfamily
M654_019555	COG0789	Transcriptional regulator
M654_019565	COG2124	cytochrome p450
M654_019570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M654_019580	COG0156	8-amino-7-oxononanoate synthase activity
M654_019585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M654_019590	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
M654_019595	COG0523	cobalamin synthesis protein
M654_019610	COG1469	GTP cyclohydrolase I activity
M654_019620	COG0583	DNA-binding transcription factor activity
M654_019625	COG0488	(ABC) transporter
M654_019630	COG0471	metal ion transport
M654_019635	COG0840	transmembrane signaling receptor activity
M654_019640	COG1012	belongs to the aldehyde dehydrogenase family
M654_019650	COG0217	transcriptional regulatory protein
M654_019655	COG0697	spore germination
M654_019675	COG0457	Tetratricopeptide repeat
M654_019725	COG3586	endonuclease activity
M654_019745	COG4282	regulation of fungal-type cell wall biogenesis
M654_019750	COG5444	nuclease activity
M654_019755	COG0457	Tetratricopeptide repeat
M654_019780	COG0457	Tetratricopeptide repeat
M654_019820	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M654_019830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M654_019835	COG1597	lipid kinase activity
M654_019840	COG1957	nucleoside hydrolase
M654_019845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M654_019850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M654_019855	COG1309	transcriptional regulator
M654_019860	COG1063	alcohol dehydrogenase
M654_019865	COG4124	Belongs to the glycosyl hydrolase 26 family
M654_019870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M654_019875	COG0154	amidase activity
M654_019880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M654_019885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M654_019895	COG1285	pathogenesis
M654_019900	COG4851	CamS sex pheromone cAM373 precursor
M654_019905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M654_019910	COG0210	DNA helicase
M654_019915	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M654_019920	COG4496	protein, YerC YecD
M654_019925	COG1470	cell adhesion involved in biofilm formation
M654_019930	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M654_019940	COG2124	cytochrome p450
M654_019950	COG0151	Belongs to the GarS family
M654_019955	COG0138	bifunctional purine biosynthesis protein purh
M654_019960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M654_019965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M654_019970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M654_019975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M654_019980	COG0047	phosphoribosylformylglycinamidine synthase activity
M654_019985	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M654_019990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M654_019995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M654_020000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M654_020005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M654_020015	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M654_020025	COG2252	PERMEase
M654_020030	COG2211	Major facilitator Superfamily
M654_020035	COG0436	Aminotransferase
M654_020055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M654_020055	COG0519	Catalyzes the synthesis of GMP from XMP
M654_020060	COG1305	Transglutaminase-like
M654_020065	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M654_020070	COG0714	Associated with various cellular activities
M654_020075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M654_020085	COG2132	Multicopper oxidase
M654_020090	COG3708	Transcriptional regulator
M654_020090	COG2207	Transcriptional regulator
M654_020095	COG0702	epimerase
M654_020110	COG0823	Involved in the tonB-independent uptake of proteins
M654_020115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M654_020135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M654_020140	COG0366	Alpha amylase catalytic
M654_020145	COG1554	hydrolase, family 65, central catalytic
M654_020150	COG5521	maltodextrose utilization protein MalA
M654_020155	COG3833	ABC-type maltose transport systems, permease component
M654_020160	COG1175	transmembrane transport
M654_020165	COG2182	Extracellular solute-binding protein
M654_020175	COG1609	Transcriptional regulator
M654_020185	COG0726	polysaccharide deacetylase
M654_020205	COG1280	lysine exporter protein (LysE YggA)
M654_020210	COG1378	Sugar-specific transcriptional regulator TrmB
M654_020220	COG2814	Major facilitator Superfamily
M654_020225	COG2272	Belongs to the type-B carboxylesterase lipase family
M654_020230	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M654_020235	COG3189	MarR family transcriptional regulator
M654_020245	COG0574	Belongs to the PEP-utilizing enzyme family
M654_020245	COG3848	Pyruvate phosphate dikinase
M654_020250	COG1309	transcriptional regulator
M654_020265	COG2135	peptidase activity
M654_020280	COG5297	Belongs to the glycosyl hydrolase family 6
M654_020295	COG1247	-acetyltransferase
M654_020315	COG1621	beta-fructofuranosidase activity
M654_020320	COG1621	beta-fructofuranosidase activity
M654_020330	COG2207	Transcriptional regulator
M654_020330	COG4753	response regulator
M654_020335	COG2972	Histidine kinase
M654_020340	COG2390	Transcriptional regulator
M654_020345	COG3731	PTS system glucitol sorbitol-specific IIA component
M654_020350	COG3732	PTS system glucitol sorbitol-specific
M654_020355	COG3730	PTS system glucitol sorbitol-specific
M654_020380	COG1494	fructose-1,6-bisphosphatase
M654_020385	COG0698	ribose 5-phosphate isomerase
M654_020390	COG1349	DNA-binding transcription factor activity
M654_020410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M654_020415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M654_020420	COG1082	Xylose isomerase domain protein TIM barrel
M654_020425	COG1028	Short-chain dehydrogenase reductase Sdr
M654_020430	COG1609	Transcriptional regulator
M654_020435	COG0459	protein refolding
M654_020440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M654_020445	COG1266	CAAX protease self-immunity
M654_020460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M654_020465	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M654_020470	COG0315	cyclic pyranopterin monophosphate synthase activity
M654_020475	COG0488	(ABC) transporter
M654_020480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M654_020485	COG0456	acetyltransferase
M654_020490	COG1214	PFAM Peptidase M22, glycoprotease
M654_020495	COG0802	atpase or kinase
M654_020500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M654_020550	COG3764	Sortase (surface protein transpeptidase)
M654_020560	COG3279	Response regulator of the LytR AlgR family
M654_020565	COG2972	Histidine kinase
M654_020565	COG0745	RESPONSE REGULATOR receiver
M654_020570	COG2814	Major facilitator Superfamily
M654_020585	COG0159	tryptophan synthase activity
M654_020590	COG0133	tryptophan synthase activity
M654_020595	COG2390	Transcriptional regulator
M654_020600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M654_020600	COG2755	lipolytic protein G-D-S-L family
M654_020610	COG5566	PFAM Mor transcription activator
M654_020620	COG1028	Short-chain dehydrogenase reductase Sdr
M654_020625	COG1309	transcriptional regulator
M654_020640	COG1113	amino acid transport
M654_020645	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M654_020660	COG0583	DNA-binding transcription factor activity
M654_020670	COG0789	Transcriptional regulator
M654_020670	COG4978	Transcriptional regulator
M654_020675	COG2814	Major facilitator Superfamily
M654_020685	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
M654_020690	COG0640	Transcriptional regulator
M654_020695	COG2808	Putative FMN-binding domain
M654_020700	COG0456	acetyltransferase
M654_020705	COG1846	Transcriptional regulator
M654_020710	COG2364	Membrane
M654_020715	COG0726	polysaccharide deacetylase
M654_020760	COG3091	SprT-like family
M654_020770	COG2183	response to ionizing radiation
M654_020775	COG2208	phosphoserine phosphatase activity
M654_020780	COG1191	sigma factor activity
M654_020795	COG2208	phosphoserine phosphatase activity
M654_020800	COG2172	sigma factor antagonist activity
M654_020805	COG1366	Belongs to the anti-sigma-factor antagonist family
M654_020810	COG1366	Belongs to the anti-sigma-factor antagonist family
M654_020815	COG2337	Toxic component of a toxin-antitoxin (TA) module
M654_020820	COG0864	Transcriptional regulator
M654_020825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M654_020830	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M654_020835	COG0705	Rhomboid family
M654_020840	COG3428	Bacterial PH domain
M654_020845	COG3402	PFAM membrane-flanked domain
M654_020850	COG0513	Belongs to the DEAD box helicase family
M654_020860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M654_020865	COG1181	Belongs to the D-alanine--D-alanine ligase family
M654_020870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M654_020885	COG1960	acyl-CoA dehydrogenase activity
M654_020895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M654_020900	COG1131	(ABC) transporter
M654_020905	COG1301	dicarboxylic acid transport
M654_020910	COG0628	permease
M654_020915	COG3729	General stress protein
M654_020920	COG0662	Cupin 2, conserved barrel domain protein
M654_020930	COG3340	Belongs to the peptidase S51 family
M654_020935	COG2217	Heavy metal translocating P-type atpase
M654_020945	COG1819	glycosyl
M654_020950	COG1027	Aspartate ammonia-lyase
M654_020955	COG2261	transglycosylase associated protein
M654_020960	COG1914	H( )-stimulated, divalent metal cation uptake system
M654_020965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M654_020975	COG3397	chitin binding
M654_020980	COG0028	Belongs to the TPP enzyme family
M654_020985	COG0551	DNA topoisomerase type I activity
M654_020985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M654_020990	COG1522	sequence-specific DNA binding
M654_021000	COG2814	Major facilitator Superfamily
M654_021015	COG3871	stress protein (general stress protein 26)
M654_021025	COG1917	Cupin 2, conserved barrel domain protein
M654_021030	COG1028	Short-chain dehydrogenase reductase Sdr
M654_021035	COG3711	transcriptional antiterminator
M654_021040	COG0246	Mannitol dehydrogenase
M654_021045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M654_021050	COG2213	PTS system mannitol-specific
M654_021055	COG2755	lipolytic protein G-D-S-L family
M654_021060	COG1414	Transcriptional regulator
M654_021065	COG1984	allophanate hydrolase subunit 2
M654_021070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M654_021075	COG4336	lyase activity
M654_021080	COG1914	H( )-stimulated, divalent metal cation uptake system
M654_021085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M654_021090	COG0561	phosphatase activity
M654_021100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M654_021115	COG5504	Zn-dependent protease
M654_021120	COG0789	Transcriptional regulator
M654_021125	COG0471	metal ion transport
M654_021130	COG1802	Transcriptional regulator
M654_021140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M654_021140	COG1587	Uroporphyrinogen-III synthase
M654_021145	COG2146	nitrite reductase [NAD(P)H] activity
M654_021150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M654_021155	COG0243	molybdopterin cofactor binding
M654_021160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M654_021165	COG1349	DNA-binding transcription factor activity
M654_021170	COG1276	copper resistance
M654_021170	COG2372	response to copper ion
M654_021175	COG4549	nuclear export factor GLE1
M654_021185	COG0697	spore germination
M654_021190	COG4221	oxidoreductase activity
M654_021195	COG1012	belongs to the aldehyde dehydrogenase family
M654_021200	COG0531	amino acid
M654_021205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M654_021210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M654_021215	COG0640	Transcriptional regulator
M654_021220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M654_021225	COG0778	Nitroreductase
M654_021230	COG1309	transcriptional regulator
M654_021235	COG2814	Major facilitator Superfamily
M654_021245	COG2273	Hydrolase Family 16
M654_021255	COG4607	ABC-type enterochelin transport system periplasmic component
M654_021260	COG4604	ABC transporter, ATP-binding protein
M654_021265	COG4605	iron ion homeostasis
M654_021270	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M654_021275	COG0527	aspartate kinase activity
M654_021280	COG0840	transmembrane signaling receptor activity
M654_021280	COG5278	phosphoserine phosphatase activity
M654_021285	COG3850	Histidine kinase
M654_021285	COG5002	protein histidine kinase activity
M654_021290	COG0745	RESPONSE REGULATOR receiver
M654_021295	COG0577	efflux transmembrane transporter activity
M654_021300	COG1136	(ABC) transporter
M654_021310	COG0789	Transcriptional regulator
M654_021315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M654_021325	COG0697	spore germination
M654_021335	COG5434	Belongs to the glycosyl hydrolase 28 family
M654_021340	COG3104	oligopeptide transport
M654_021350	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
M654_021355	COG1874	Beta-galactosidase
M654_021360	COG0456	acetyltransferase
M654_021360	COG1846	Transcriptional regulator
M654_021365	COG2271	Major facilitator Superfamily
M654_021375	COG4214	carbohydrate transport
M654_021385	COG4213	ABC transporter substrate-binding protein
M654_021390	COG2197	response regulator
M654_021395	COG2972	Histidine kinase
M654_021475	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M654_021480	COG0163	prenyltransferase activity
M654_021485	COG0583	DNA-binding transcription factor activity
M654_021490	COG0010	Belongs to the arginase family
M654_021495	COG0833	amino acid
M654_021500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M654_021505	COG3829	transcription factor binding
M654_021510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M654_021515	COG0765	amino acid transport
M654_021520	COG1126	abc transporter atp-binding protein
M654_021575	COG2364	Membrane
M654_021580	COG2207	Transcriptional regulator
M654_021580	COG3708	Transcriptional regulator
M654_021585	COG2819	hydrolase of the alpha beta superfamily
M654_021595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M654_021600	COG0697	spore germination
M654_021605	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M654_021610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M654_021615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M654_021620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M654_021625	COG2814	Major facilitator Superfamily
M654_021635	COG1176	ABC-type spermidine putrescine transport system, permease component I
M654_021645	COG3842	ATPase activity
M654_021665	COG5444	nuclease activity
M654_021675	COG0840	transmembrane signaling receptor activity
M654_021675	COG3290	protein histidine kinase activity
M654_021690	COG2723	6-phospho-beta-galactosidase activity
M654_021705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M654_021710	COG0765	amino acid transport
M654_021725	COG3458	cephalosporin-C deacetylase activity
M654_021730	COG0701	Predicted permease
M654_021735	COG3689	TIGRFAM TIGR03943 family protein
M654_021740	COG2508	Transcriptional regulator
M654_021745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M654_021750	COG1012	belongs to the aldehyde dehydrogenase family
M654_021755	COG0506	proline dehydrogenase activity
M654_021760	COG3541	Predicted nucleotidyltransferase
M654_021770	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M654_021775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M654_021780	COG1113	amino acid transport
M654_021785	COG1280	lysine exporter protein (LysE YggA)
M654_021790	COG1620	l-lactate permease
M654_021795	COG0039	L-malate dehydrogenase activity
M654_021800	COG2814	Major facilitator Superfamily
M654_021805	COG2223	nitrite transmembrane transporter activity
M654_021810	COG0785	Cytochrome C biogenesis protein
M654_021815	COG3853	Toxic anion resistance protein (TelA)
M654_021835	COG1358	cellular component organization or biogenesis
M654_021850	COG0861	Integral membrane protein TerC family
M654_021855	COG2310	stress, protein
M654_021860	COG2310	stress, protein
M654_021865	COG2310	stress, protein
M654_021890	COG1131	(ABC) transporter
M654_021900	COG3883	PFAM NLP P60 protein
M654_021900	COG0791	NLP P60 protein
M654_021905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M654_021910	COG3773	Cell wall hydrolase
M654_021920	COG1595	DNA-templated transcription, initiation
M654_021925	COG3591	Belongs to the peptidase S1B family
M654_021940	COG3394	polysaccharide catabolic process
M654_021945	COG2188	Transcriptional regulator
M654_021950	COG1486	melibiose metabolic process
M654_021955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M654_021960	COG1447	Phosphotransferase system cellobiose-specific component IIA
M654_021970	COG0277	FAD linked oxidase domain protein
M654_021975	COG0247	lactate metabolic process
M654_021985	COG2261	transglycosylase associated protein
M654_021990	COG1164	Oligoendopeptidase f
M654_022000	COG0456	acetyltransferase
M654_022005	COG0252	asparaginase activity
M654_022025	COG1288	antiporter activity
M654_022035	COG4106	trans-aconitate 2-methyltransferase activity
M654_022040	COG1028	Short-chain dehydrogenase reductase Sdr
M654_022045	COG1028	Short-chain dehydrogenase reductase Sdr
M654_022055	COG1942	4-Oxalocrotonate Tautomerase
M654_022060	COG0583	DNA-binding transcription factor activity
M654_022085	COG1131	(ABC) transporter
M654_022095	COG3012	SEC-C Motif Domain Protein
M654_022095	COG1405	negative regulation of cell septum assembly
M654_022105	COG0697	spore germination
M654_022120	COG0789	Transcriptional regulator
M654_022145	COG0318	PFAM AMP-dependent synthetase and ligase
M654_022150	COG1846	Transcriptional regulator
M654_022155	COG3173	Aminoglycoside phosphotransferase
M654_022220	COG1131	(ABC) transporter
M654_022225	COG2205	protein histidine kinase activity
M654_022230	COG0745	RESPONSE REGULATOR receiver
M654_022235	COG2721	sulfolactate sulfo-lyase activity
M654_022240	COG2186	Transcriptional regulator
M654_022245	COG4948	Mandelate Racemase Muconate Lactonizing
M654_022250	COG2271	Major facilitator Superfamily
M654_022255	COG1012	belongs to the aldehyde dehydrogenase family
M654_022260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M654_022265	COG0805	protein transport
M654_022270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M654_022275	COG3540	Alkaline phosphatase
M654_022300	COG0784	Response regulator, receiver
M654_022305	COG4191	Histidine kinase
M654_022310	COG2066	Belongs to the glutaminase family
M654_022315	COG1115	amino acid carrier protein
M654_022320	COG2304	oxidoreductase activity
M654_022325	COG2205	protein histidine kinase activity
M654_022335	COG2323	membrane
M654_022350	COG1263	PTS System
M654_022350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_022350	COG2190	(PTS) system
M654_022355	COG3394	polysaccharide catabolic process
M654_022360	COG2040	homocysteine
M654_022365	COG0833	amino acid
M654_022370	COG4257	antibiotic catabolic process
M654_022385	COG4213	ABC transporter substrate-binding protein
M654_022390	COG0840	transmembrane signaling receptor activity
M654_022395	COG0371	Dehydrogenase
M654_022430	COG2207	Transcriptional regulator
M654_022430	COG1917	Cupin 2, conserved barrel domain protein
M654_022435	COG0697	spore germination
M654_022445	COG3409	Peptidoglycan-binding domain 1 protein
M654_022465	COG4682	membrane
M654_022470	COG1283	sodium-dependent phosphate transmembrane transporter activity
M654_022485	COG2409	Drug exporters of the RND superfamily
M654_022485	COG1033	growth of symbiont in host cell
M654_022490	COG1846	Transcriptional regulator
M654_022500	COG0730	response to heat
M654_022505	COG1802	Transcriptional regulator
M654_022510	COG0778	Nitroreductase
M654_022515	COG0076	glutamate decarboxylase activity
M654_022525	COG4122	O-methyltransferase activity
M654_022540	COG2002	toxin-antitoxin pair type II binding
M654_022550	COG3764	Sortase (surface protein transpeptidase)
M654_022560	COG0860	N-Acetylmuramoyl-L-alanine amidase
M654_022565	COG0791	NLP P60 protein
M654_022565	COG1388	LysM domain
M654_022585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_022590	COG1733	regulation of RNA biosynthetic process
M654_022595	COG0662	Cupin 2, conserved barrel domain protein
M654_022600	COG0730	response to heat
M654_022605	COG0425	Belongs to the sulfur carrier protein TusA family
M654_022610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M654_022610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M654_022625	COG2210	Belongs to the sulfur carrier protein TusA family
M654_022630	COG1937	Protein conserved in bacteria
M654_022640	COG1331	Highly conserved protein containing a thioredoxin domain
M654_022650	COG0542	response to heat
M654_022660	COG1331	Highly conserved protein containing a thioredoxin domain
M654_022685	COG2211	Major facilitator Superfamily
M654_022695	COG0583	DNA-binding transcription factor activity
M654_022700	COG2814	Major facilitator Superfamily
M654_022710	COG3711	transcriptional antiterminator
M654_022715	COG1063	alcohol dehydrogenase
M654_022730	COG1113	amino acid transport
M654_022735	COG1011	Hydrolase
M654_022740	COG1357	PFAM Pentapeptide repeats (8 copies)
M654_022745	COG1794	racemase activity, acting on amino acids and derivatives
M654_022760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M654_022765	COG1132	(ABC) transporter
M654_022790	COG1131	(ABC) transporter
M654_022800	COG2814	Major facilitator Superfamily
M654_022805	COG0640	Transcriptional regulator
M654_022815	COG1733	regulation of RNA biosynthetic process
M654_022820	COG2249	NAD(P)H dehydrogenase (quinone) activity
M654_022835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M654_022840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M654_022845	COG4856	YbbR-like protein
M654_022850	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M654_022855	COG5662	AntiSigma factor
M654_022860	COG1595	DNA-templated transcription, initiation
M654_022895	COG1683	Conserved Protein
M654_022900	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M654_022905	COG1737	Transcriptional regulator
M654_022910	COG1263	PTS System
M654_022910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M654_022915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M654_022920	COG1472	Belongs to the glycosyl hydrolase 3 family
M654_022925	COG3876	Protein conserved in bacteria
M654_022940	COG0385	Bile acid
M654_022950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M654_022995	COG0726	polysaccharide deacetylase
M654_023000	COG2194	sulfuric ester hydrolase activity
M654_023010	COG0489	protein tyrosine kinase activity
M654_023015	COG0860	N-Acetylmuramoyl-L-alanine amidase
M654_023025	COG2318	DinB family
M654_023040	COG0101	tRNA pseudouridine synthase activity
M654_023045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M654_023050	COG1122	ATPase activity
M654_023055	COG1122	ATPase activity
M654_023060	COG0203	ribosomal protein L17
M654_023065	COG0202	RNA polymerase activity
M654_023070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M654_023075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M654_023080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M654_023085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M654_023090	COG2163	COG2163 Ribosomal protein L14E L6E L27E
M654_023095	COG0024	Methionine aminopeptidase
M654_023100	COG0563	adenylate kinase activity
M654_023105	COG0201	protein transport
M654_023110	COG0200	Binds to the 23S rRNA
M654_023125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M654_023130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M654_023135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M654_023140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M654_023145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M654_023150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M654_023155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M654_023160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M654_023165	COG0255	Belongs to the universal ribosomal protein uL29 family
M654_023170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M654_023175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M654_023180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M654_023185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M654_023190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M654_023195	COG0089	rRNA binding
M654_023200	COG0088	Forms part of the polypeptide exit tunnel
M654_023205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M654_023215	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M654_023220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M654_023225	COG0049	tRNA binding
M654_023230	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M654_023235	COG1358	cellular component organization or biogenesis
M654_023240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M654_023245	COG0085	RNA polymerase activity
M654_023250	COG2813	Specifically methylates the guanine in position
M654_023255	COG0222	ribosome binding
M654_023260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M654_023265	COG0081	regulation of translation
M654_023270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M654_023275	COG0250	Participates in transcription elongation, termination and antitermination
M654_023285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M654_023295	COG3688	RNA-binding protein containing a PIN domain
M654_023300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M654_023305	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M654_023310	COG0215	cysteine-tRNA ligase activity
M654_023315	COG1045	serine acetyltransferase
M654_023320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M654_023325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M654_023330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M654_023335	COG4956	integral membrane protein (PIN domain superfamily)
M654_023340	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M654_023345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M654_023350	COG0542	response to heat
M654_023355	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M654_023360	COG3880	PFAM UvrB UvrC protein
M654_023365	COG4463	regulation of RNA biosynthetic process