locus-tag class description OXB_0001 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP OXB_0002 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase OXB_0007 ENOG4108RMU ferritin dps family protein OXB_0010 ENOG4108IPT Naphthoate synthase OXB_0011 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) OXB_0012 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) OXB_0013 ENOG4105E4F Isochorismate synthase OXB_0014 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase OXB_0018 ENOG4105KT7 mgtC SapB transporter OXB_0020 ENOG4107QW4 alcohol dehydrogenase OXB_0022 ENOG4105D82 Glutamate dehydrogenase OXB_0023 ENOG4105C8Y Acetylornithine aminotransferase OXB_0024 ENOG4105C26 Dehydrogenase OXB_0025 ENOG4108JUB Transcriptional regulator OXB_0029 ENOG4105C87 Aminotransferase class I and II OXB_0031 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) OXB_0033 ENOG4105BZ4 penicillin-binding protein OXB_0036 ENOG4105D65 subunit l OXB_0037 ENOG4105HC0 Na H antiporter OXB_0038 ENOG4108ZE9 Monovalent cation H antiporter subunit C OXB_0039 ENOG4108JPZ Monovalent cation H antiporter subunit D OXB_0040 ENOG4105SC1 monovalent cation H antiporter subunit E OXB_0042 ENOG4105KJM monovalent cation h antiporter subunit g OXB_0044 ENOG4105CH6 catalase OXB_0049 ENOG4105CEP NADH dehydrogenase OXB_0050 ENOG4108YX9 iron--sulfur cluster insertion protein erpA OXB_0052 ENOG41083MR nifu domain-containing protein OXB_0055 ENOG4105ZKE UPF0349 protein OXB_0056 ENOG4105D4U had-superfamily hydrolase, subfamily iia OXB_0058 ENOG4105MMD transcriptional regulator OXB_0059 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) OXB_0061 ENOG4105C8J )-transporter OXB_0062 ENOG4107S6Z Na H antiporter OXB_0063 ENOG4108YTE sporulation protein YunB OXB_0064 ENOG4107R8B 5'-nucleotidase OXB_0066 ENOG4105I3N Conserved Protein OXB_0067 ENOG4105DIW FeS assembly protein SUFB OXB_0068 ENOG4108UNV SUF system FeS assembly protein, NifU family OXB_0070 ENOG4105JRK feS assembly protein SufD OXB_0071 ENOG4105C3K feS assembly ATPase SufC OXB_0073 ENOG4105D01 (LipO)protein OXB_0074 ENOG4108UMI ABC transporter, permease OXB_0075 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) OXB_0078 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) OXB_0079 ENOG41080E8 Transcriptional regulator, Spx MgsR family OXB_0080 ENOG4105C1G acyl-Coa dehydrogenase OXB_0081 ENOG4105CHU acetyl-coa acetyltransferase OXB_0083 ENOG4105SZ6 Thioredoxin OXB_0091 ENOG4105JVQ RNA Polymerase OXB_0094 ENOG4105CMR udp-glucose 4-epimerase OXB_0095 ENOG4105D3Q Sugar transferase OXB_0096 ENOG4108UXE Protein tyrosine phosphatase OXB_0097 ENOG4107R5R arsenical pump membrane protein OXB_0098 ENOG41082YX Transcriptional regulator, arsr family OXB_0100 ENOG4105DJB Major Facilitator Superfamily OXB_0101 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B OXB_0105 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate OXB_0108 ENOG4108M8W Monooxygenase OXB_0110 ENOG4105E8R UPF0173 metal-dependent hydrolase OXB_0111 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_0113 ENOG4105RD8 TRAP dicarboxylate transporter OXB_0115 ENOG4107V0Z fmn reductase OXB_0116 ENOG4108M8W Monooxygenase OXB_0121 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) OXB_0131 ENOG4105BZU Histidine kinase OXB_0137 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) OXB_0142 ENOG4107R3N Filamentation induced by cAMP protein fic OXB_0143 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) OXB_0144 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) OXB_0146 ENOG4105XZU Preprotein translocase, subunit SecG OXB_0149 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) OXB_0151 ENOG4105CP7 Triose-phosphate isomerase OXB_0152 ENOG4105BZA Phosphoglycerate kinase OXB_0156 ENOG4108V0P LemA family OXB_0157 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) OXB_0158 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) OXB_0160 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) OXB_0161 ENOG4105D06 uba thif-type nad fad binding protein OXB_0165 ENOG4105KRI phosphocarrier protein (HPr OXB_0166 ENOG4105CIE May be required for sporulation (By similarity) OXB_0167 ENOG4105CHW UPF0052 protein OXB_0168 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) OXB_0169 ENOG4108Z4K mutator MutT protein OXB_0170 ENOG4105C3M thioredoxin reductase OXB_0172 ENOG4108S4C acetyltransferase OXB_0173 ENOG4107XGZ Hydrolase OXB_0174 ENOG4105HKU nucleoside recognition domain-containing protein OXB_0175 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) OXB_0176 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) OXB_0177 ENOG4105E5H Transposase OXB_0180 ENOG4108PY7 OXB_0181 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) OXB_0182 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) OXB_0186 ENOG4105NBU tryptophan transport protein OXB_0188 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) OXB_0190 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) OXB_0191 ENOG4105EQI Metal Dependent Phosphohydrolase OXB_0192 ENOG4106D4I domain protein OXB_0193 ENOG4107VRP DNA repair exonuclease OXB_0194 ENOG4105RHA ABC transporter, permease OXB_0195 ENOG4108IUX (ABC) transporter OXB_0197 ENOG4106A7E Transcriptional regulator OXB_0199 ENOG4108Z5K methylglyoxal synthase OXB_0201 ENOG4105CGU Enoyl-CoA hydratase OXB_0202 ENOG4105D4P Coproporphyrinogen iii oxidase OXB_0203 ENOG4105WZB UPF0342 protein OXB_0204 ENOG4108UH6 UPF0754 membrane protein OXB_0206 ENOG410606W general stress protein OXB_0207 ENOG4105C82 Malate synthase OXB_0213 ENOG4105C37 (CBS) domain OXB_0215 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase OXB_0216 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) OXB_0217 ENOG4105K63 Thioredoxin OXB_0218 ENOG4108YBP pseudouridine synthase OXB_0220 ENOG4105C7N Xanthine uracil vitamin C permease OXB_0222 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) OXB_0223 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) OXB_0231 ENOG4105TUA UPF0295 protein OXB_0232 ENOG4105G5W regulator Fur family OXB_0234 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OXB_0235 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase OXB_0236 ENOG4107NBY Membrane OXB_0237 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component OXB_0238 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component OXB_0239 ENOG4105DEF Extracellular solute-binding protein, family 5 OXB_0240 ENOG4108JQ7 (ABC) transporter OXB_0241 ENOG4105C3U ABC transporter OXB_0242 ENOG4105BZ1 (ABC) transporter OXB_0243 ENOG4105EVI UPF0374 protein OXB_0246 ENOG41067AE Membrane-bound metal-dependent hydrolase OXB_0249 ENOG4105ECP epimerase OXB_0255 ENOG4105C59 p-type ATPase OXB_0256 ENOG4107U9T Pfam:Ribonuclease_BN OXB_0258 ENOG4105BZG amino acid carrier protein OXB_0259 ENOG41068PA UPF0435 protein OXB_0260 ENOG4105ER2 Ompa motb domain protein OXB_0261 ENOG4105E14 MotA TolQ exbB proton channel OXB_0264 ENOG4108V2W Carbonate dehydratase OXB_0265 ENOG4105D9U N-acetyltransferase OXB_0267 ENOG4105N67 Proton-coupled thiamine transporter YuaJ OXB_0269 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) OXB_0270 ENOG4105FDU atp-dependent rna helicase OXB_0271 ENOG4105CG9 aspartate racemase OXB_0274 ENOG4105C8Q Methyl-accepting chemotaxis OXB_0275 ENOG4105C8Q Methyl-accepting chemotaxis OXB_0276 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) OXB_0277 ENOG4105CDA abc transporter atp-binding protein OXB_0278 ENOG4105E5Q amino acid AbC transporter OXB_0279 ENOG4106TNF Periplasmic binding protein OXB_0280 ENOG4108IV0 ABC, transporter OXB_0281 ENOG4105CP9 extracellular ligand-binding receptor OXB_0283 ENOG4105C32 Amino acid ABC transporter (Permease) OXB_0284 ENOG4108IQE Amp-dependent synthetase and ligase OXB_0285 ENOG4105C0Z ABC transporter OXB_0287 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) OXB_0289 ENOG41069ER domain protein OXB_0290 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) OXB_0291 ENOG4105C8Q Methyl-accepting chemotaxis OXB_0301 ENOG4108UTW Plays a role in the regulation of phosphate uptake OXB_0311 ENOG4105VN1 Heat shock protein OXB_0314 ENOG4105E5H Transposase OXB_0315 ENOG4105WEF catalase OXB_0318 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) OXB_0322 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) OXB_0323 ENOG4105CBD Diacylglycerol kinase OXB_0325 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) OXB_0326 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) OXB_0327 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) OXB_0329 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) OXB_0330 ENOG4105C4R Atp-dependent dna helicase OXB_0333 ENOG4105KGF protein, YerC YecD OXB_0334 ENOG4108R5T secreted protein OXB_0341 ENOG4105C12 Phosphoribosylglycinamide synthetase OXB_0342 ENOG4105DC1 bifunctional purine biosynthesis protein purh OXB_0343 ENOG4108V3E phosphoribosylglycinamide formyltransferase OXB_0344 ENOG4105CXB phosphoribosylaminoimidazole synthetase OXB_0348 ENOG4105VR9 phosphoribosylformylglycinamidine synthase OXB_0349 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit OXB_0350 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) OXB_0352 ENOG4108U5N UPF0316 protein OXB_0355 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) OXB_0358 ENOG4105C7N Xanthine uracil vitamin C permease OXB_0359 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) OXB_0362 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OXB_0363 ENOG4107RA1 nh(3)-dependent nad( ) synthetase OXB_0364 ENOG4105DAP Nicotinate phosphoribosyltransferase OXB_0366 ENOG4105C28 cystathionine OXB_0367 ENOG4105C28 cystathionine OXB_0368 ENOG4106IPI cyclase, family OXB_0370 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) OXB_0379 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) OXB_0380 ENOG4107QR9 Iron-sulfur cluster binding protein OXB_0381 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) OXB_0384 ENOG4105C5H ABC transporter OXB_0386 ENOG4105CZM Major Facilitator OXB_0387 ENOG4105C0R drug resistance transporter emrb qaca subfamily OXB_0388 ENOG4107MII Sugar-specific transcriptional regulator TrmB OXB_0389 ENOG4107RIQ Sulfate adenylate transferase OXB_0392 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) OXB_0393 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_0395 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit OXB_0396 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) OXB_0399 ENOG4107RSM transcriptional regulator OXB_0406 ENOG4105C26 Dehydrogenase OXB_0416 ENOG4105D3R alkyl hydroperoxide reductase OXB_0418 ENOG4107FQ9 ethanolamine ammonia-lyase OXB_0419 ENOG4105CPD ethanolamine ammonia-lyase OXB_0420 ENOG4105E3J oxidoreductase OXB_0422 ENOG4105CYW agmatinase OXB_0427 ENOG4105CUY Mechanosensitive ion channel OXB_0428 ENOG4105CAY ferredoxin--nadp reductase OXB_0429 ENOG4105E0A ABC, transporter OXB_0430 ENOG4108IHU transport system permease protein OXB_0431 ENOG4105DQ5 transport system permease protein OXB_0432 ENOG4108MES Periplasmic binding protein OXB_0433 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) OXB_0436 ENOG41082BV acetyltransferase OXB_0437 ENOG4105DXX methyltransferase OXB_0439 ENOG4105E0A ABC, transporter OXB_0440 ENOG4105TVJ transport system, permease OXB_0441 ENOG4105DQ5 transport system permease protein OXB_0448 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) OXB_0449 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) OXB_0450 ENOG4108TYN CAAX amino terminal protease family protein OXB_0451 ENOG4105C26 Dehydrogenase OXB_0454 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) OXB_0455 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) OXB_0456 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) OXB_0457 ENOG4105C5H ABC transporter OXB_0458 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) OXB_0459 ENOG410801F ribosomal-protein-alanine acetyltransferase OXB_0460 ENOG41072GX Peptidase M22 Glycoprotease OXB_0461 ENOG4105K8N protein family UPF0079, ATPase OXB_0464 ENOG41064BQ Phosphatase OXB_0466 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) OXB_0468 ENOG4107SGM protein serine threonine phosphatase OXB_0469 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase OXB_0470 ENOG4105FUA antagonist OXB_0471 ENOG4107MMM Anti-sigma-factor antagonist OXB_0472 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) OXB_0475 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein OXB_0476 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) OXB_0478 ENOG4105CKV Membrane OXB_0479 ENOG410905X membrane-flanked domain protein OXB_0480 ENOG4105C1J atp-dependent rna helicase OXB_0482 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) OXB_0483 ENOG4105CPF Cell wall formation (By similarity) OXB_0489 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) OXB_0498 ENOG4105QNR S1 RNA binding domain protein OXB_0499 ENOG4105KST dependent repressor OXB_0504 ENOG4107YZX Universal stress protein OXB_0505 ENOG4105KJM monovalent cation h antiporter subunit g OXB_0507 ENOG4105IMY monovalent cation H antiporter subunit E OXB_0508 ENOG4108JPZ Monovalent cation H antiporter subunit D OXB_0509 ENOG4108ZE9 Monovalent cation H antiporter subunit C OXB_0510 ENOG4105GND monovalent cation H antiporter subunit B OXB_0511 ENOG4105D65 subunit l OXB_0514 ENOG4105D4A Cell wall formation (By similarity) OXB_0515 ENOG4107ZXU DSBA oxidoreductase OXB_0517 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase OXB_0521 ENOG4107RKG DJ-1/PfpI family OXB_0523 ENOG4105BZ1 (ABC) transporter OXB_0525 ENOG41079KZ Major Facilitator Superfamily OXB_0526 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) OXB_0529 ENOG4108IPW abc transporter atp-binding protein OXB_0530 ENOG4105CM4 permease protein OXB_0531 ENOG4105DHS permease protein OXB_0533 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) OXB_0537 ENOG4105CK7 Sodium proline symporter OXB_0538 ENOG4107Y2X deaminase OXB_0539 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) OXB_0540 ENOG4105CEY Amp-dependent synthetase and ligase OXB_0543 ENOG4105C6T cysteine synthase OXB_0547 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA OXB_0548 ENOG4105JVQ RNA Polymerase OXB_0554 ENOG4105JVQ RNA Polymerase OXB_0555 ENOG4108P49 AntiSigma factor OXB_0557 ENOG4105C9Q fumarate hydratase class II OXB_0558 ENOG4105C2C drug resistance transporter, Bcr CflA OXB_0559 ENOG4105DZ6 Band 7 protein OXB_0561 ENOG4107GRR phosphate transport regulator OXB_0562 ENOG4105CJ3 phosphate transporter OXB_0567 ENOG4105DHI Methyltransferase OXB_0569 ENOG4105E2A Dehydrogenase OXB_0574 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase OXB_0575 ENOG4107T2D Phosphoribosylaminoimidazolesuccinocarboxamide synthase OXB_0579 ENOG4105CDY transcriptional regulatory protein OXB_0582 ENOG4105CJ1 ABC, transporter OXB_0586 ENOG4108ZUB Lysine exporter protein (Lyse ygga) OXB_0587 ENOG4105DR4 Methyltransferase OXB_0588 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_0590 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit OXB_0592 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase OXB_0593 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) OXB_0596 ENOG41060WC Enoyl-CoA hydratase OXB_0597 ENOG4105CHU acetyl-coa acetyltransferase OXB_0598 ENOG4105CEY Amp-dependent synthetase and ligase OXB_0599 ENOG4107Z3H Transcriptional regulator, TetR family OXB_0600 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase OXB_0601 ENOG4105C1G acyl-Coa dehydrogenase OXB_0602 ENOG4105CEY Amp-dependent synthetase and ligase OXB_0603 ENOG4108IV0 ABC, transporter OXB_0604 ENOG4105C0Z ABC transporter OXB_0606 ENOG4105C32 Amino acid ABC transporter (Permease) OXB_0608 ENOG4107TXC Transcriptional regulator OXB_0612 ENOG4105FQP Beta-lactamase OXB_0613 ENOG4105K8R UPF0145 protein OXB_0615 ENOG4108NEV two component transcriptional regulator, LytTR family OXB_0616 ENOG4108HRK Histidine kinase OXB_0617 ENOG4105CVA phosphate OXB_0620 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ OXB_0621 ENOG4105EXS phosphate abc transporter OXB_0622 ENOG4105C8U phosphate abc transporter OXB_0623 ENOG4105E2Z phosphate ABC transporter (Permease OXB_0624 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) OXB_0625 ENOG4105BZU Histidine kinase OXB_0626 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_0629 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_0630 ENOG4105BZU Histidine kinase OXB_0631 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) OXB_0632 ENOG4107U5W ybbr family OXB_0633 ENOG4105C8B TIGR00159 family OXB_0635 ENOG4105EMN RNA polymerase sigma factor OXB_0642 ENOG4105D1F ATP-binding protein OXB_0645 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein OXB_0647 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) OXB_0649 ENOG4105DEN Luciferase family OXB_0655 ENOG4105DRR Transcriptional regulator, GntR family OXB_0657 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit OXB_0658 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter OXB_0659 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_0660 ENOG4105CQB FAD linked oxidase domain protein OXB_0664 ENOG4108TF4 von Willebrand factor, type A OXB_0665 ENOG4108YYS metal-dependent hydrolase (By similarity) OXB_0669 ENOG4105CZV ABC transporter OXB_0670 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family OXB_0672 ENOG4105D3Y Na H antiporter OXB_0673 ENOG4105D3Y Na H antiporter OXB_0675 ENOG4105C84 Histidine ammonia-lyase OXB_0676 ENOG4108UJD 30S ribosomal protein S9 OXB_0677 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) OXB_0678 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) OXB_0679 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) OXB_0680 ENOG4108JJB ABC transporter OXB_0681 ENOG4108JJB ABC transporter OXB_0682 ENOG4108ZT0 50S ribosomal protein l17 OXB_0683 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OXB_0684 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) OXB_0685 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits OXB_0686 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) OXB_0688 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) OXB_0689 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) OXB_0691 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) OXB_0692 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) OXB_0693 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) OXB_0694 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) OXB_0696 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits OXB_0697 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) OXB_0698 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) OXB_0699 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal OXB_0700 ENOG41082SA 50s ribosomal protein l29 OXB_0701 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) OXB_0702 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) OXB_0703 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) OXB_0704 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) OXB_0705 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity OXB_0706 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) OXB_0707 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) OXB_0708 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) OXB_0709 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) OXB_0711 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) OXB_0713 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) OXB_0714 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) OXB_0715 ENOG4105XPM ribosomal protein OXB_0716 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OXB_0717 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OXB_0718 ENOG4107Y49 methyltransferase OXB_0719 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) OXB_0720 ENOG4108VZM 50s ribosomal protein L10 OXB_0721 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) OXB_0722 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) OXB_0723 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) OXB_0725 ENOG4105QIV RNA polymerase OXB_0726 ENOG4105M0M Tetracycline resistance protein OXB_0727 ENOG4105C2N RNA methyltransferase TrmH family group 3 OXB_0729 ENOG4105C8N cysteinyl-tRNA synthetase OXB_0730 ENOG4105D7W serine acetyltransferase OXB_0731 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) OXB_0732 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) OXB_0733 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) OXB_0734 ENOG4105CTP PilT protein domain protein OXB_0735 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) OXB_0737 ENOG41066A3 ATP guanido phosphotransferase OXB_0738 ENOG4108Z0C Uvrb UvrC protein OXB_0742 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) OXB_0747 ENOG4105CVP deoxyribo-dipyrimidine photolyase OXB_0750 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) OXB_0752 ENOG4105KIR Thiol-disulfide oxidoreductase dcc OXB_0754 ENOG4105C26 Dehydrogenase OXB_0755 ENOG4105C0H protease OXB_0756 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_0757 ENOG4105BZU Histidine kinase OXB_0758 ENOG4105W1N transcriptional regulator OXB_0759 ENOG4105IIP Membrane OXB_0760 ENOG4105CS1 NAD(P)H quinone oxidoreductase OXB_0761 ENOG4105FBA Phospholipase Carboxylesterase OXB_0763 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase OXB_0764 ENOG4105DWF phosphomethylpyrimidine kinase OXB_0765 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) OXB_0768 ENOG4106S2D Transcriptional regulator OXB_0772 ENOG4105EA8 2-Nitropropane dioxygenase OXB_0778 ENOG4108S01 response regulator OXB_0779 ENOG4108ZGX Histidine kinase OXB_0780 ENOG4105ECK Fatty Acid Desaturase OXB_0781 ENOG4105CHR reductase OXB_0783 ENOG410841Q phosphoesterase PA-phosphatase related protein OXB_0785 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) OXB_0789 ENOG4105C4B ABC transporter, permease OXB_0790 ENOG4108IXI (ABC) transporter OXB_0791 ENOG4108TU7 Inherit from COG: (ABC) transporter OXB_0792 ENOG4105CJ1 ABC, transporter OXB_0793 ENOG4105CZV ABC transporter OXB_0794 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family OXB_0803 ENOG4105E1K spore germination protein OXB_0806 ENOG4105C8Q Methyl-accepting chemotaxis OXB_0807 ENOG4108S4H thioesterase Superfamily protein OXB_0808 ENOG4107SN7 NLP P60 protein OXB_0809 ENOG4105DTQ mandelate racemase muconate lactonizing OXB_0810 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A OXB_0813 ENOG4108AQF aminoglycoside N(3)-acetyltransferase OXB_0814 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) OXB_0815 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) OXB_0816 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase OXB_0817 ENOG4105DK0 Indole-3-glycerol phosphate synthase OXB_0818 ENOG4108I0Q anthranilate phosphoribosyltransferase OXB_0819 ENOG4105CRQ synthase (Component I) OXB_0825 ENOG4105FE9 pseudouridine synthase OXB_0826 ENOG4105CJW magnesium transporter OXB_0828 ENOG4105CYC Transferase OXB_0830 ENOG4105DEU major facilitator superfamily OXB_0831 ENOG4105CHU acetyl-coa acetyltransferase OXB_0832 ENOG4105C1G acyl-Coa dehydrogenase OXB_0834 ENOG4105CEY Amp-dependent synthetase and ligase OXB_0835 ENOG4105E39 Enoyl-CoA hydratase OXB_0836 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase OXB_0837 ENOG4105G9B Transcriptional regulator OXB_0838 ENOG4105MSY salicylate hydroxylase OXB_0840 ENOG4105ERH Fumarylacetoacetate hydrolase OXB_0842 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_0844 ENOG41062YB Trap dicarboxylate transporter, dctp subunit OXB_0845 ENOG4105E5W Transporter OXB_0846 ENOG4105DZS Phenylacetate-CoA ligase OXB_0848 ENOG4107258 Transcriptional regulator OXB_0850 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase OXB_0854 ENOG4108IV0 ABC, transporter OXB_0855 ENOG4105C0Z ABC transporter OXB_0856 ENOG4105CF8 branched-chain amino acid ABC transporter, permease OXB_0857 ENOG4105C32 Amino acid ABC transporter (Permease) OXB_0859 ENOG4105CZM Major Facilitator OXB_0861 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase OXB_0862 ENOG4105KVH Transcriptional regulator OXB_0864 ENOG4105BZU Histidine kinase OXB_0866 ENOG4105C26 Dehydrogenase OXB_0868 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_0870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit OXB_0872 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) OXB_0873 ENOG4105CQB FAD linked oxidase domain protein OXB_0874 ENOG4108KWP DNA-binding transcriptional regulator GlcC OXB_0876 ENOG4105DTE Xanthine uracil vitamin C permease OXB_0877 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) OXB_0882 ENOG4108TF4 von Willebrand factor, type A OXB_0883 ENOG4107KM7 Heat induced stress protein YflT OXB_0885 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase OXB_0886 ENOG4105CNG UPF0061 protein OXB_0887 ENOG4105F6S Spore photoproduct lyase OXB_0890 ENOG4105D01 (LipO)protein OXB_0891 ENOG4108UMI ABC transporter, permease OXB_0892 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) OXB_0895 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) OXB_0897 ENOG4105DWT malate dehydrogenase (quinone) OXB_0901 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) OXB_0903 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism OXB_0904 ENOG4108V9W transcriptional regulatory protein OXB_0908 ENOG4107AYK membrAne OXB_0918 ENOG4105PKS Excinuclease abc c subunit domain protein OXB_0930 ENOG4105DZR Type I site-specific deoxyribonuclease OXB_0937 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) OXB_0939 ENOG4105C0H protease OXB_0942 ENOG4105Q2H domain protein OXB_0945 ENOG4105BZU Histidine kinase OXB_0946 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_0947 ENOG4105E4C Lytic transglycosylase catalytic OXB_0948 ENOG4105CDU Replicative dna helicase OXB_0949 ENOG4105K9Q Binds to the 23S rRNA (By similarity) OXB_0950 ENOG4105BZR domain protein OXB_0952 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) OXB_0953 ENOG4108UUM single-stranded DNA-binding protein OXB_0956 ENOG4105C3G gtp-binding protein OXB_0957 ENOG4105VDK protein, conserved in bacteria OXB_0958 ENOG4105D8X mechanosensitive ion channel OXB_0959 ENOG4108ZDA Sporulation protein YyaC OXB_0960 ENOG4108UQV Membrane OXB_0961 ENOG4105FA0 parb-like partition protein OXB_0962 ENOG4107QJE Chromosome Partitioning Protein OXB_0963 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) OXB_0964 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) OXB_0965 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) OXB_0966 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) OXB_0968 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins OXB_0969 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) OXB_0970 ENOG4105VG0 50S ribosomal protein l34 OXB_0971 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) OXB_0972 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) OXB_0974 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) OXB_0975 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) OXB_0976 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) OXB_0977 ENOG4105CPI Metal Dependent Phosphohydrolase OXB_0981 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) OXB_0983 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family OXB_0984 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) OXB_0985 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) OXB_0986 ENOG4108Z6B deaminase OXB_0988 ENOG4105ZMH deoxynucleoside kinase OXB_0989 ENOG4105CFH Aspartokinase OXB_0990 ENOG4105D6E homoserine dehydrogenase OXB_0991 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) OXB_0992 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) OXB_0994 ENOG4105C6E dna polymerase iii OXB_0995 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) OXB_0996 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) OXB_1003 ENOG4105CXN decarboxylase OXB_1004 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) OXB_1005 ENOG4105X0R protein from nitrogen regulatory protein P-II OXB_1006 ENOG4105XVJ Protein of unknown function (DUF327) OXB_1007 ENOG4105FA2 dna polymerase iii OXB_1008 ENOG4105MA4 psp1 domain protein OXB_1009 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) OXB_1010 ENOG41060K3 Methyltransferase OXB_1011 ENOG4105VC4 domain protein OXB_1012 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) OXB_1013 ENOG4105KRN Transcriptional regulator, abrb family OXB_1015 ENOG4105F8V Hydrolase, tatD family OXB_1016 ENOG41069ER domain protein OXB_1017 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) OXB_1018 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) OXB_1019 ENOG4105W42 Veg protein OXB_1021 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) OXB_1022 ENOG4105DFT pur operon repressor OXB_1023 ENOG4105KME endoribonuclease L-psp OXB_1025 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) OXB_1026 ENOG4105C5T Phosphoribosyl pyrophosphate synthase OXB_1027 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) OXB_1028 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) OXB_1030 ENOG4108JA2 transcriptioN-repair coupling factor OXB_1031 ENOG4108M14 stage v sporulation protein t OXB_1033 ENOG4108IY2 MazG family OXB_1034 ENOG41082I2 s4 domain protein OXB_1035 ENOG4105VYY sporulation protein yabp OXB_1038 ENOG41060GV RNA binding s1 domain protein OXB_1040 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) OXB_1041 ENOG4108UGV hypoxanthine phosphoribosyltransferase OXB_1042 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) OXB_1043 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) OXB_1044 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) OXB_1045 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase OXB_1046 ENOG4105C6T cysteine synthase OXB_1047 ENOG4105CRQ synthase (Component I) OXB_1048 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 OXB_1049 ENOG4105EEI dihydropteroate synthase OXB_1050 ENOG4105KRF dihydroneopterin aldolase OXB_1051 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase OXB_1052 ENOG4105CRK lysyL-tRNA synthetase OXB_1056 ENOG4107U9T Pfam:Ribonuclease_BN OXB_1058 ENOG4105BZU Histidine kinase OXB_1060 ENOG4105EYF MMPL domain protein OXB_1070 ENOG4107SCJ type I restriction enzyme EcoKI subunit R OXB_1080 ENOG4105E0C molybdate abc transporter OXB_1081 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein OXB_1087 ENOG4108Z12 YiaAB two helix domain-containing protein OXB_1089 ENOG4105EU9 OXB_1090 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic OXB_1091 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) OXB_1099 ENOG4105KTU Transcriptional regulator, arsr family OXB_1100 ENOG4105PGM cation diffusion facilitator family transporter OXB_1101 ENOG4105VPX protein, conserved in bacteria OXB_1102 ENOG410681U heavy metal transport detoxification protein OXB_1103 ENOG4105C59 p-type ATPase OXB_1106 ENOG4105CFC Transporter OXB_1114 ENOG4105BZU Histidine kinase OXB_1117 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) OXB_1118 ENOG4107R8N Glycosyl transferase, family 2 OXB_1120 ENOG4108NEV two component transcriptional regulator, LytTR family OXB_1121 ENOG4105EMN RNA polymerase sigma factor OXB_1123 ENOG4105CQB FAD linked oxidase domain protein OXB_1127 ENOG4105C32 Amino acid ABC transporter (Permease) OXB_1128 ENOG4105CF8 branched-chain amino acid ABC transporter, permease OXB_1129 ENOG4105C0Z ABC transporter OXB_1130 ENOG4108IV0 ABC, transporter OXB_1131 ENOG4105E1K spore germination protein OXB_1132 ENOG4108Q5U germination protein, ger(x)c family OXB_1137 ENOG4105I03 Flagellin OXB_1139 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) OXB_1140 ENOG4105D94 Major Facilitator Superfamily OXB_1142 ENOG41067MG lrgb family OXB_1153 ENOG4105CYC Transferase OXB_1154 ENOG4105C5X domain protein OXB_1155 ENOG41085GJ domain protein OXB_1156 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component OXB_1160 ENOG4105C1G acyl-Coa dehydrogenase OXB_1161 ENOG4105C1G acyl-Coa dehydrogenase OXB_1162 ENOG4108IPT Naphthoate synthase OXB_1163 ENOG4105CEY Amp-dependent synthetase and ligase OXB_1164 ENOG4105CHR reductase OXB_1165 ENOG4107ZQV short-chain dehydrogenase reductase OXB_1166 ENOG4105C1G acyl-Coa dehydrogenase OXB_1167 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase OXB_1168 ENOG4105E39 Enoyl-CoA hydratase OXB_1170 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) OXB_1171 ENOG4105DUM transcriptional regulator, lysR family OXB_1172 ENOG4105HMI Membrane OXB_1174 ENOG4105XTG Pfam:DUF156 OXB_1175 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase OXB_1177 ENOG4105VFE sira family OXB_1178 ENOG4107TPS domain protein OXB_1179 ENOG4105VFE sira family OXB_1180 ENOG41087NI Sulfite exporter TauE/SafE OXB_1181 ENOG4105F27 Major Facilitator OXB_1182 ENOG4108Y1J Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) OXB_1184 ENOG4105DZS Phenylacetate-CoA ligase OXB_1185 ENOG4105C32 Amino acid ABC transporter (Permease) OXB_1186 ENOG4105C32 Amino acid ABC transporter (Permease) OXB_1187 ENOG4105C0Z ABC transporter OXB_1188 ENOG4108IV0 ABC, transporter OXB_1191 ENOG4105CAY ferredoxin--nadp reductase OXB_1193 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit OXB_1199 ENOG4108UKI Enoyl-CoA hydratase OXB_1200 ENOG4105C26 Dehydrogenase OXB_1201 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase OXB_1202 ENOG4105CHU acetyl-coa acetyltransferase OXB_1203 ENOG4105E39 Enoyl-CoA hydratase OXB_1204 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein OXB_1205 ENOG4108Z0R Transferase OXB_1206 ENOG4105EA8 2-Nitropropane dioxygenase OXB_1207 ENOG4105FKZ Methyl-accepting chemotaxis OXB_1208 ENOG4108V06 Glutathione peroxidase OXB_1211 ENOG4108RPX mosc domain containing protein OXB_1212 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) OXB_1213 ENOG4108YYH Nadph-dependent fmn reductase OXB_1214 ENOG4108RNG Permease of the drug metabolite transporter OXB_1219 ENOG4105BZU Histidine kinase OXB_1223 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) OXB_1224 ENOG4108P62 biosynthesis protein (CbiG) OXB_1225 ENOG4105CIA precorrin-4 C(11)-methyltransferase OXB_1226 ENOG4105DVK Precorrin-2 c20-methyltransferase OXB_1227 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase OXB_1228 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) OXB_1229 ENOG41081F0 Precorrin-8x methylmutase OXB_1230 ENOG4108JTQ reductase OXB_1231 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein OXB_1232 ENOG4105E4R Precorrin-3B C17-methyltransferase OXB_1233 ENOG4105E0A ABC, transporter OXB_1234 ENOG4105EHG Permease protein OXB_1237 ENOG4105S10 periplasmic binding protein OXB_1238 ENOG4105EHG Permease protein OXB_1239 ENOG4105E0A ABC, transporter OXB_1240 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) OXB_1242 ENOG4105IIU Aminopeptidase OXB_1243 ENOG4105WH1 Two component transcriptional regulator luxr family OXB_1248 ENOG4105CHU acetyl-coa acetyltransferase OXB_1251 ENOG4105CEY Amp-dependent synthetase and ligase OXB_1254 ENOG4107T5V SNARE associated Golgi OXB_1255 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) OXB_1256 ENOG4108RQ5 Beta-lactamase domain-containing protein OXB_1258 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_1259 ENOG41062D9 Histidine kinase OXB_1261 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer OXB_1265 ENOG4105DY9 regulatoR OXB_1266 ENOG4108HQR Glycine betaine OXB_1267 ENOG4105E90 ABC transporter OXB_1268 ENOG4108IJ8 ABC transporter OXB_1269 ENOG4105CJZ response regulator OXB_1270 ENOG4105EWM Histidine kinase OXB_1271 ENOG4105C19 ABC transporter OXB_1272 ENOG4108HVR ABC transporter, permease OXB_1273 ENOG4108UN4 phage SPO1 DNA polymerase-related protein OXB_1277 ENOG4108IUE nitrate reductase beta subunit OXB_1281 ENOG4105BZU Histidine kinase OXB_1282 ENOG4105WH1 Two component transcriptional regulator luxr family OXB_1285 ENOG4105D06 uba thif-type nad fad binding protein OXB_1286 ENOG4105EPU Molybdenum cofactor synthesis domain protein OXB_1287 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) OXB_1288 ENOG4105CVM Molybdenum cofactor synthesis domain protein OXB_1290 ENOG4108ZAF Molybdopterin OXB_1292 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) OXB_1293 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) OXB_1296 ENOG4105ENY Ethanolamine utilization protein eutH OXB_1297 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place OXB_1298 ENOG4106S4J ethanolamine utilization protein EutP OXB_1299 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase OXB_1300 ENOG4105CPD ethanolamine ammonia-lyase OXB_1301 ENOG4107FQ9 ethanolamine ammonia-lyase OXB_1302 ENOG4106D67 ethanolamine utilization protein OXB_1303 ENOG4108EKI Dehydrogenase OXB_1304 ENOG4105KNY Microcompartments protein OXB_1306 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml OXB_1307 ENOG4105KNY Microcompartments protein OXB_1308 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) OXB_1313 ENOG41060AI SEC-C motif OXB_1315 ENOG41067SE Tetr family transcriptional regulator OXB_1316 ENOG4105C0R drug resistance transporter emrb qaca subfamily OXB_1317 ENOG41060AI SEC-C motif OXB_1318 ENOG4105C26 Dehydrogenase OXB_1320 ENOG4105C1G acyl-Coa dehydrogenase OXB_1321 ENOG41080UQ Transcriptional regulator OXB_1322 ENOG4105C28 cystathionine OXB_1325 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) OXB_1327 ENOG4105CYW agmatinase OXB_1328 ENOG4105CHM Aminotransferase OXB_1330 ENOG4105ECB domain protein OXB_1331 ENOG4105CYX Short-chain dehydrogenase reductase Sdr OXB_1332 ENOG4107QPK )-transporter OXB_1334 ENOG4105DWK Membrane OXB_1335 ENOG4107XM3 UPF0442 protein OXB_1336 ENOG4105BZU Histidine kinase OXB_1337 ENOG4108UZ3 Transporter OXB_1340 ENOG4105DVE abc transporter atp-binding protein OXB_1341 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family OXB_1342 ENOG4105BZ1 (ABC) transporter OXB_1343 ENOG4105BZ1 (ABC) transporter OXB_1346 ENOG4105D58 Diguanylate phosphodiesterase OXB_1350 ENOG4105EPR degv family OXB_1352 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) OXB_1353 ENOG4108JU6 CBS domain protein OXB_1354 ENOG4105EMN RNA polymerase sigma factor OXB_1359 ENOG4107V0Z fmn reductase OXB_1360 ENOG4105C9U ATP-dependent DNA helicase RecQ OXB_1362 ENOG4108Z66 YbaK ebsC protein OXB_1365 ENOG4105DWD nucleoside recognition domain protein OXB_1366 ENOG4108TN2 lmbE family OXB_1371 ENOG4105DWF phosphomethylpyrimidine kinase OXB_1373 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) OXB_1375 ENOG4105M08 Membrane OXB_1378 ENOG4107JTW chlorite dismutase OXB_1379 ENOG4108IJ2 phosphate acetyltransferase OXB_1381 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) OXB_1382 ENOG4108VCI transcription factor, rsfa family OXB_1383 ENOG4105DCI Phosphohydrolase OXB_1385 ENOG41069HH 4-oxalocrotonate tautomerase OXB_1386 ENOG4108XFG YwhD family OXB_1388 ENOG4105BZ4 penicillin-binding protein OXB_1392 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) OXB_1394 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) OXB_1395 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) OXB_1398 ENOG4108WBT adenosyltransferase OXB_1399 ENOG4105DF6 Fe-S oxidoreductase OXB_1401 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase OXB_1402 ENOG4105C1G acyl-Coa dehydrogenase OXB_1403 ENOG4105C1G acyl-Coa dehydrogenase OXB_1404 ENOG4105W1N transcriptional regulator OXB_1405 ENOG4105D5P Methylmalonyl-coA mutase OXB_1408 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) OXB_1411 ENOG4105BZU Histidine kinase OXB_1413 ENOG410812K response regulator receiver protein OXB_1414 ENOG4105D2N Aldolase OXB_1415 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) OXB_1416 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) OXB_1417 ENOG4105CBT Fructose-1,6-bisphosphatase OXB_1418 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) OXB_1419 ENOG41082DI 50s ribosomal protein l31 OXB_1421 ENOG4107104 thymidine kinase OXB_1423 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) OXB_1424 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) OXB_1425 ENOG4108ZXQ stage ii sporulation protein r OXB_1426 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) OXB_1429 ENOG4105C8Q Methyl-accepting chemotaxis OXB_1430 ENOG4108YZG isomerase OXB_1431 ENOG4108UIC UPF0340 protein OXB_1432 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) OXB_1434 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) OXB_1435 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase OXB_1436 ENOG41062M3 atp synthase OXB_1437 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) OXB_1438 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) OXB_1439 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) OXB_1440 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) OXB_1442 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) OXB_1443 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) OXB_1444 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) OXB_1445 ENOG4106778 Protein of unknown function (DUF1146) OXB_1450 ENOG4105MT0 Sporulation transcriptional regulator spoiiid OXB_1451 ENOG4105DFF Rod shape-determining protein mreb OXB_1453 ENOG4105CGA flagellar basal-body rod protein FlgG OXB_1462 ENOG4105Z8H single-stranded DNA-binding protein OXB_1465 ENOG4105C0D helicase OXB_1467 ENOG4108IMY Transcriptional regulator OXB_1472 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) OXB_1474 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) OXB_1478 ENOG4105K4I Scp-like extracellular OXB_1482 ENOG4105HIR S-layer domain protein OXB_1502 ENOG4105CFC Transporter OXB_1503 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) OXB_1505 ENOG4105C7B Threonine dehydratase OXB_1506 ENOG4105CI2 imidazolone-5-propionate hydrolase OXB_1508 ENOG4105C9B Cysteine desulfurase OXB_1515 ENOG4107T66 Releases the N-terminal proline from various substrates (By similarity) OXB_1517 ENOG4105DEF Extracellular solute-binding protein, family 5 OXB_1518 ENOG4105C0P Mg chelatase subunit ChlI OXB_1520 ENOG4108HRK Histidine kinase OXB_1521 ENOG4105EQD regulatoR OXB_1523 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component OXB_1524 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component OXB_1526 ENOG4108JQ7 (ABC) transporter OXB_1534 ENOG4107R3N Filamentation induced by cAMP protein fic OXB_1548 ENOG4105C94 Transporter OXB_1549 ENOG4105C0H protease OXB_1552 ENOG4105CI2 imidazolone-5-propionate hydrolase OXB_1554 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component OXB_1555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component OXB_1557 ENOG4108JQ7 (ABC) transporter OXB_1562 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component OXB_1563 ENOG4105KVH Transcriptional regulator OXB_1570 ENOG4105CBC glutamate synthase OXB_1571 ENOG4105DMF Dehydrogenase OXB_1572 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease OXB_1574 ENOG4105CIY formyltetrahydrofolate deformylase OXB_1575 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin OXB_1576 ENOG4105FKZ Methyl-accepting chemotaxis OXB_1577 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase OXB_1578 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) OXB_1579 ENOG4105E0A ABC, transporter OXB_1580 ENOG4105EHG Permease protein OXB_1581 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) OXB_1586 ENOG4105IEH endo-beta-N-acetylglucosaminidase OXB_1595 ENOG4107BJW polysaccharide deacetylase OXB_1597 ENOG4105DTN riboflavin biosynthesis protein ribF OXB_1598 ENOG4105CEC DNA methylase N-4 N-6 OXB_1603 ENOG4105DTQ mandelate racemase muconate lactonizing OXB_1604 ENOG4105QEK Transcriptional regulator OXB_1606 ENOG4105CK7 Sodium proline symporter OXB_1608 ENOG4105DTQ mandelate racemase muconate lactonizing OXB_1609 ENOG4108K88 Membrane OXB_1612 ENOG4105C01 Dihydroxy-acid dehydratase OXB_1613 ENOG4105C7K acetolactate synthase OXB_1614 ENOG4108ZP8 Acetolactate synthase small subunit OXB_1615 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase OXB_1616 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) OXB_1617 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) OXB_1618 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) OXB_1619 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) OXB_1623 ENOG4108SHJ s-layer protein OXB_1629 ENOG4105DY9 regulatoR OXB_1633 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase OXB_1634 ENOG4107TT5 NLP P60 protein OXB_1635 ENOG4107RA4 Glycosyl transferase (Group 1 OXB_1637 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase OXB_1638 ENOG4105CHH sulfate transporter OXB_1643 ENOG4107RQ2 Cytochrome c oxidase, subunit I OXB_1644 ENOG4105NAA Cytochrome C oxidase, subunit II OXB_1646 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) OXB_1647 ENOG4107TT5 NLP P60 protein OXB_1651 ENOG4105ESV Glycosyl transferase, family 4 OXB_1652 ENOG4108KGH TRANSCRIPTIONal OXB_1653 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein OXB_1654 ENOG4105BZU Histidine kinase OXB_1655 ENOG4105WH1 Two component transcriptional regulator luxr family OXB_1660 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation OXB_1661 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) OXB_1662 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) OXB_1663 ENOG4105C1Q protoporphyrinogen oxidase OXB_1666 ENOG4107VXM glycerophosphoryl diester phosphodiesterase OXB_1667 ENOG4105DF9 Lipoate-protein, ligase OXB_1672 ENOG4105CEY Amp-dependent synthetase and ligase OXB_1675 ENOG4105DA5 (ABC) transporter OXB_1680 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein OXB_1683 ENOG4105CJ1 ABC, transporter OXB_1684 ENOG41090VJ ABC-2 type transporter OXB_1685 ENOG4108IG5 Transcriptional regulator OXB_1686 ENOG4108IJ0 Aspartate ammonia-lyase OXB_1688 ENOG4105I03 Flagellin OXB_1690 ENOG4105E39 Enoyl-CoA hydratase OXB_1691 ENOG4105EPR degv family OXB_1699 ENOG4105E1Q flagellar hook-associated protein OXB_1700 ENOG4105DTJ flagellar hook-associated protein OXB_1701 ENOG4105MKD OXB_1704 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) OXB_1705 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) OXB_1706 ENOG4105I03 Flagellin OXB_1712 ENOG4105EKQ RNA-directed DNA polymerase OXB_1715 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_1718 ENOG4105ERH Fumarylacetoacetate hydrolase OXB_1719 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) OXB_1732 ENOG4105KTH gatB Yqey OXB_1736 ENOG4106YBV Methyl-accepting chemotaxis OXB_1738 ENOG4107RT6 flagellar hook-associated OXB_1739 ENOG4105MQ3 flagellar protein FliS OXB_1741 ENOG4108W2P Methyl-accepting chemotaxis OXB_1744 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving OXB_1745 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) OXB_1749 ENOG4105CAK Cell division ATP-binding protein ftsE OXB_1750 ENOG4105CRP Part of the ABC transporter FtsEX involved in OXB_1751 ENOG4105DR5 peptidase OXB_1753 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OXB_1754 ENOG4105CN1 protease OXB_1758 ENOG4105CHR reductase OXB_1760 ENOG4105C8Y Acetylornithine aminotransferase OXB_1761 ENOG4105CUV Homoserine Kinase OXB_1762 ENOG4107R55 ethanolamine transporter OXB_1763 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) OXB_1766 ENOG4105KNY Microcompartments protein OXB_1768 ENOG4108X49 Ethanolamine utilization protein EutK OXB_1769 ENOG4105KNY Microcompartments protein OXB_1770 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) OXB_1772 ENOG4108UMN azlc family OXB_1782 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination OXB_1783 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation OXB_1784 ENOG4105DHF Membrane OXB_1785 ENOG4105ERH Fumarylacetoacetate hydrolase OXB_1787 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) OXB_1788 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase OXB_1789 ENOG4105EPR degv family OXB_1790 ENOG4108KP7 hydrolase OXB_1791 ENOG4108MXZ Esterase OXB_1792 ENOG4105VG1 fes assembly suf system protein OXB_1796 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit OXB_1798 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) OXB_1799 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) OXB_1802 ENOG4105C31 Tryptophanyl-tRNA synthetase OXB_1805 ENOG4108J59 Extracellular solute-binding protein, family 5 OXB_1806 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component OXB_1807 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component OXB_1809 ENOG4108JQ7 (ABC) transporter OXB_1811 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) OXB_1812 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis OXB_1814 ENOG4105DPN Oligoendopeptidase f OXB_1816 ENOG4105T58 Dithiol-disulfide isomerase OXB_1817 ENOG4108Z18 K06886 hemoglobin OXB_1818 ENOG4105E4C Lytic transglycosylase catalytic OXB_1819 ENOG4106EFP UPF0738 protein OXB_1821 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) OXB_1822 ENOG4105EMS pseudouridine synthase OXB_1823 ENOG4107S1Q Phosphatase OXB_1824 ENOG4105CJW magnesium transporter OXB_1828 ENOG41090VF Stage v sporulation protein ac OXB_1829 ENOG4105CZ3 stage V sporulation protein ad OXB_1834 ENOG41082BV acetyltransferase OXB_1835 ENOG4108ZMI UPF0477 protein OXB_1838 ENOG4105CDA abc transporter atp-binding protein OXB_1839 ENOG4105CT1 (ABC) transporter OXB_1840 ENOG4105EAD ABC transporter OXB_1841 ENOG4105DRP amino acid AbC transporter OXB_1843 ENOG4105E39 Enoyl-CoA hydratase OXB_1844 ENOG4108UZ3 Transporter OXB_1845 ENOG4108UZ3 Transporter OXB_1850 ENOG4108JQ5 ABC transporter OXB_1851 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component OXB_1853 ENOG4105C0R drug resistance transporter emrb qaca subfamily OXB_1854 ENOG4105CH6 catalase OXB_1856 ENOG4105C26 Dehydrogenase OXB_1857 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) OXB_1859 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) OXB_1862 ENOG4107TS3 membrane protein, TerC OXB_1865 ENOG4105BZU Histidine kinase OXB_1866 ENOG41090MY MarR family Transcriptional regulator OXB_1871 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase OXB_1873 ENOG4105BZU Histidine kinase OXB_1874 ENOG4105K6S Short-chain dehydrogenase reductase Sdr OXB_1877 ENOG4105C0R drug resistance transporter emrb qaca subfamily OXB_1880 ENOG4105CJ1 ABC, transporter OXB_1883 ENOG4105C7R Atpase associated with various cellular activities aaa_3 OXB_1888 ENOG4107RUE extracellular solute-binding protein family 1 OXB_1889 ENOG4105D38 putrescine abc transporter OXB_1890 ENOG4105F38 ABC transporter, permease OXB_1891 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) OXB_1895 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OXB_1896 ENOG4107ZYR domain protein OXB_1899 ENOG4105CN5 Metallo-Beta-Lactamase OXB_1900 ENOG4106148 UPF0356 protein OXB_1901 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) OXB_1904 ENOG4105CPP Dehydrogenase, E1 component OXB_1905 ENOG4105C7S Dehydrogenase OXB_1907 ENOG4105WBI UPF0223 protein OXB_1910 ENOG4105ECY inositol monophosphatase OXB_1912 ENOG4105CI3 gtp-binding protein typa OXB_1913 ENOG4105QA2 OXB_1916 ENOG4105ZPI UPF0358 protein OXB_1917 ENOG4105CNI cell division protein FtsW OXB_1918 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) OXB_1919 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) OXB_1920 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) OXB_1926 ENOG4108SJC Membrane OXB_1931 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) OXB_1933 ENOG4108QXE glycerophosphoryl diester phosphodiesterase OXB_1934 ENOG4105WUC UPF0298 protein OXB_1937 ENOG4106H78 methyltransferase OXB_1938 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) OXB_1940 ENOG41063PX domain protein OXB_1941 ENOG4105CDE UPF0348 protein OXB_1943 ENOG41067VY 50S ribosomal protein L32 OXB_1944 ENOG4105E39 Enoyl-CoA hydratase OXB_1945 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase OXB_1946 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit OXB_1947 ENOG4107QX3 carboxylase OXB_1948 ENOG4107S3C Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) OXB_1950 ENOG41074B2 UPF0747 protein OXB_1951 ENOG4108V6E Cell division protein mraZ OXB_1952 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) OXB_1953 ENOG41068DC Essential cell division protein (By similarity) OXB_1954 ENOG4105CJN penicillin-binding protein OXB_1955 ENOG4105CJN penicillin-binding protein OXB_1956 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) OXB_1957 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) OXB_1958 ENOG4105CNI cell division protein FtsW OXB_1959 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) OXB_1960 ENOG4108R2U division initiation protein OXB_1962 ENOG4105K67 small basic protein OXB_1963 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) OXB_1964 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) OXB_1966 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OXB_1969 ENOG4105DFA alanine racemase domain protein OXB_1970 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) OXB_1971 ENOG41067XK integral membrane protein OXB_1972 ENOG4105DBK s4 domain protein OXB_1975 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) OXB_1976 ENOG4105C34 Pseudouridine synthase OXB_1977 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) OXB_1979 ENOG4105CXT aspartate transcarbamylase OXB_1980 ENOG4105CD3 dihydroorotase OXB_1981 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain OXB_1982 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain OXB_1983 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) OXB_1984 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) OXB_1985 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) OXB_1986 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) OXB_1990 ENOG4105F23 Fibronectin-binding protein OXB_1991 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) OXB_1992 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) OXB_1993 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase OXB_1994 ENOG4105C25 Primosomal protein n' OXB_1995 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) OXB_1996 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) OXB_1997 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B OXB_1998 ENOG4108ZF3 Phosphatase OXB_1999 ENOG4105D9P serine threonine protein kinase OXB_2000 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) OXB_2001 ENOG4105DJV ribulose-phosphate 3-epimerase OXB_2003 ENOG4105VB9 50S ribosomal protein l28 OXB_2004 ENOG4108ZAA Alkaline-shock protein OXB_2005 ENOG4105DP4 dak2 domain fusion protein ylov OXB_2007 ENOG4105EJQ L-serine dehydratase OXB_2008 ENOG4105CB5 ATP-dependent DNA helicase recG OXB_2009 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) OXB_2010 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) OXB_2011 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase OXB_2012 ENOG4105CHR reductase OXB_2013 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) OXB_2014 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) OXB_2015 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) OXB_2016 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) OXB_2017 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) OXB_2019 ENOG4105K5M 30s ribosomal protein S16 OXB_2020 ENOG4105VB6 UPF0109 protein OXB_2021 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) OXB_2022 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) OXB_2023 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) OXB_2025 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) OXB_2026 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) OXB_2028 ENOG4105VM1 flagellar OXB_2029 ENOG4105CMV Succinyl-CoA synthetase subunit beta OXB_2030 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha OXB_2031 ENOG4105C79 DNA protecting protein DprA OXB_2032 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) OXB_2033 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) OXB_2034 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) OXB_2035 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) OXB_2036 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) OXB_2037 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) OXB_2039 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) OXB_2040 ENOG4108ZC9 flagellar basal-body rod protein flgc OXB_2041 ENOG4105VQ0 flagellar hook-basal body complex protein fliE OXB_2042 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) OXB_2043 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) OXB_2046 ENOG4106YF4 Flagellar biosynthesis chaperone OXB_2049 ENOG410822I Flagellar hook capping protein OXB_2051 ENOG4108JQA flagellar OXB_2052 ENOG41068WV flagellar FlbD family protein OXB_2054 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) OXB_2055 ENOG4105DD5 Flagellar motor switch protein OXB_2056 ENOG4107YTP response regulator receiver protein OXB_2058 ENOG4105CN7 Flagellar biosynthetic protein FliP OXB_2059 ENOG4105VS8 Flagellar biosynthetic protein fliq OXB_2060 ENOG4105D19 Role in flagellar biosynthesis (By similarity) OXB_2061 ENOG4105D00 flagellar biosynthetic protein flhB OXB_2063 ENOG4105D7B Flagellar biosynthesis protein flha OXB_2064 ENOG4105FZW flagellar biosynthesis regulator FlhF OXB_2066 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) OXB_2067 ENOG4105CBS Chea signal transduction histidine kinase OXB_2068 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis OXB_2070 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) OXB_2071 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OXB_2074 ENOG4105CE9 30S ribosomal protein S2 OXB_2075 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) OXB_2076 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) OXB_2077 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) OXB_2078 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) OXB_2079 ENOG4105KNE Phosphatidate cytidylyltransferase OXB_2080 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) OXB_2081 ENOG4105DZP Membrane-associated zinc metalloprotease OXB_2082 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) OXB_2083 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) OXB_2084 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) OXB_2085 ENOG4105CHV Transcription elongation factor NusA OXB_2086 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination OXB_2087 ENOG4105VHM ribosomal protein OXB_2089 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) OXB_2091 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) OXB_2093 ENOG4105DTN riboflavin biosynthesis protein ribF OXB_2094 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) OXB_2095 ENOG4108X4Q Hydrolase OXB_2096 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) OXB_2097 ENOG4105C1V Peptidase, M16 OXB_2100 ENOG4108S0H Dipicolinic acid synthetase, b subunit OXB_2101 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) OXB_2102 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) OXB_2103 ENOG4105CN5 Metallo-Beta-Lactamase OXB_2105 ENOG4105FDP GntR family transcriptional regulator OXB_2106 ENOG4105DIH basic membrane OXB_2107 ENOG4108JQ9 ABC transporter OXB_2108 ENOG4105UIB (ABC) transporter OXB_2112 ENOG4108RKS Short-chain dehydrogenase reductase Sdr OXB_2115 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase OXB_2116 ENOG4105CEV competence damage-inducible protein OXB_2117 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) OXB_2118 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) OXB_2119 ENOG4105D48 metallophosphoesterase OXB_2120 ENOG4105MCT stage V sporulation protein S OXB_2121 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) OXB_2124 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) OXB_2125 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) OXB_2126 ENOG4105C6V Glycerol-3-phosphate dehydrogenase OXB_2128 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) OXB_2130 ENOG4105CXI aluminum resistance protein OXB_2131 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) OXB_2133 ENOG4108SVB resolvase OXB_2134 ENOG4105VPS UPF0291 protein OXB_2145 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase OXB_2146 ENOG4105CHU acetyl-coa acetyltransferase OXB_2149 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity OXB_2150 ENOG4107R6F Alpha Beta Hydrolase Fold protein OXB_2154 ENOG4107RT3 EamA-like transporter family OXB_2155 ENOG4107258 Transcriptional regulator OXB_2158 ENOG4105P4J Allophanate hydrolase, subunit 1 OXB_2159 ENOG4105E7W lamb ycsf family protein OXB_2160 ENOG4105C5A transporter OXB_2162 ENOG4105CFM UPF0317 protein OXB_2163 ENOG4105C8Q Methyl-accepting chemotaxis OXB_2164 ENOG4105WG9 Conserved Protein OXB_2165 ENOG4107AYK membrAne OXB_2170 ENOG4105UPD Calcium Proton OXB_2178 ENOG410900G Protein of unknown function (DUF421) OXB_2179 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase OXB_2180 ENOG4105C8Q Methyl-accepting chemotaxis OXB_2184 ENOG4105C0H protease OXB_2185 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator OXB_2186 ENOG4105BZ7 extracellular solute-binding protein family 1 OXB_2188 ENOG4105DRS transport system, permease OXB_2191 ENOG4105D4U had-superfamily hydrolase, subfamily iia OXB_2194 ENOG4105C8Q Methyl-accepting chemotaxis OXB_2197 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase OXB_2199 ENOG4105PAD Hydrolase OXB_2201 ENOG4105HIR S-layer domain protein OXB_2208 ENOG4105D6U Sodium Glutamate Symporter OXB_2209 ENOG41088SP formiminoglutamate hydrolase OXB_2210 ENOG4105DUM transcriptional regulator, lysR family OXB_2211 ENOG4105CYN Serine protein kinase OXB_2212 ENOG4106AKX UPF0229 protein OXB_2213 ENOG4105ED1 spovr family OXB_2215 ENOG4105C5H ABC transporter OXB_2217 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component OXB_2219 ENOG4105ETU transcriptional activator (TenA OXB_2220 ENOG4105C5F glutamine synthetase OXB_2221 ENOG4105KZD Domain of unknown function (DUF1805) OXB_2223 ENOG4105CI2 imidazolone-5-propionate hydrolase OXB_2225 ENOG41080TC multidrug resistance protein OXB_2227 ENOG4108QXE glycerophosphoryl diester phosphodiesterase OXB_2230 ENOG4105E0Y RtcB Protein OXB_2232 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) OXB_2234 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase OXB_2236 ENOG4108SJC Membrane OXB_2238 ENOG4105H67 Protein of unknown function (DUF421) OXB_2242 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OXB_2244 ENOG4105DJ4 phosphatidylserine decarboxylase OXB_2246 ENOG4108Z7G MaoC domain protein dehydratase OXB_2250 ENOG4105EMN RNA polymerase sigma factor OXB_2252 ENOG4105CHR reductase OXB_2255 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F OXB_2256 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) OXB_2259 ENOG4105CEY Amp-dependent synthetase and ligase OXB_2261 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family OXB_2263 ENOG4108YBP pseudouridine synthase OXB_2266 ENOG4105CM2 brancheD-chain amino acid aminotransferase OXB_2268 ENOG4105C7J ABC transporter, permease OXB_2270 ENOG4105BZU Histidine kinase OXB_2271 ENOG4107VFR oxidoreductase OXB_2272 ENOG4105CGK Exodeoxyribonuclease III OXB_2273 ENOG4105DJ2 Major Facilitator Superfamily OXB_2274 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) OXB_2275 ENOG4105C2W permease OXB_2276 ENOG4108PB2 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) OXB_2277 ENOG41068WN OXB_2278 ENOG4108RCF TRANSCRIPTIONal OXB_2280 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component OXB_2282 ENOG4106PMH Extracellular solute-binding protein family 3 OXB_2284 ENOG4105CPC Aldo Keto reductase OXB_2285 ENOG4108YZ4 nudix hydrolase OXB_2287 ENOG4105I3K Ferric uptake regulator, Fur family OXB_2288 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) OXB_2290 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) OXB_2292 ENOG4105CDU Replicative dna helicase OXB_2296 ENOG4105CVR type I restriction-modification system OXB_2297 ENOG4105EKX Restriction modification system DNA (Specificity OXB_2298 ENOG4105DZR Type I site-specific deoxyribonuclease OXB_2299 ENOG41082AN stage II sporulation protein OXB_2300 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) OXB_2301 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OXB_2303 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) OXB_2306 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) OXB_2307 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) OXB_2308 ENOG4105DZ1 carboxypeptidase OXB_2309 ENOG4105FE9 pseudouridine synthase OXB_2310 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen OXB_2311 ENOG4107TWT Cytochrome c biogenesis protein OXB_2312 ENOG4105CRE cytochrome C OXB_2313 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_2314 ENOG4105BZU Histidine kinase OXB_2317 ENOG4108SAX Membrane OXB_2319 ENOG4105T7X OXB_2320 ENOG4105C9U ATP-dependent DNA helicase RecQ OXB_2322 ENOG4107RGJ metallophosphoesterase OXB_2323 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase OXB_2325 ENOG4105F0V Cell wall hydrolase OXB_2328 ENOG4105CAT Cytidine monophosphate kinase OXB_2330 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) OXB_2332 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase OXB_2335 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) OXB_2337 ENOG4105EUJ GTP cyclohydrolase i OXB_2339 ENOG4105XXQ heptaprenyl diphosphate synthase component I OXB_2340 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) OXB_2342 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) OXB_2343 ENOG4105BZU Histidine kinase OXB_2344 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase OXB_2345 ENOG4105D49 3-dehydroquinate synthase OXB_2346 ENOG4105KHN chorismate mutase OXB_2347 ENOG4105CIH Imidazole acetol-phosphate transaminase OXB_2349 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase OXB_2350 ENOG41068YB TPR repeat-containing protein OXB_2354 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) OXB_2355 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit OXB_2358 ENOG4108JYZ YitT family OXB_2359 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase OXB_2360 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) OXB_2361 ENOG4105CPK Glycosyl transferase (Group 1 OXB_2363 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase OXB_2364 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) OXB_2365 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) OXB_2366 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) OXB_2367 ENOG4105DVT helicase OXB_2371 ENOG4105CSM endonuclease III OXB_2373 ENOG4105BZ4 penicillin-binding protein OXB_2375 ENOG4105C0D helicase OXB_2378 ENOG4105D6U Sodium Glutamate Symporter OXB_2379 ENOG4105CK2 sodium dicarboxylate symporter OXB_2380 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) OXB_2381 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) OXB_2382 ENOG4106PMH Extracellular solute-binding protein family 3 OXB_2383 ENOG4105EAD ABC transporter OXB_2388 ENOG4105C26 Dehydrogenase OXB_2389 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family OXB_2390 ENOG4105BZU Histidine kinase OXB_2391 ENOG4105C0A alcohol dehydrogenase OXB_2393 ENOG4105P8F nudix hydrolase OXB_2395 ENOG4105FUY alpha subunit OXB_2396 ENOG4108SBK dioxygenase, subunit beta OXB_2397 ENOG4105ID8 Transcriptional regulator, ARAC family OXB_2398 ENOG4105RD8 TRAP dicarboxylate transporter OXB_2403 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) OXB_2406 ENOG4105DEN Luciferase family OXB_2411 ENOG41069NU Nitroreductase OXB_2413 ENOG4105BZ1 (ABC) transporter OXB_2418 ENOG4105CH6 catalase OXB_2427 ENOG4105BZU Histidine kinase OXB_2428 ENOG4105BZU Histidine kinase OXB_2432 ENOG4105EHG Permease protein OXB_2451 ENOG4107XNQ Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) OXB_2456 ENOG4105KJF protein tyrosine phosphatase OXB_2460 ENOG4105E5Q amino acid AbC transporter OXB_2466 ENOG4107TUM Amidinotransferase OXB_2475 ENOG4108I5C dEAD DEAH box helicase OXB_2481 ENOG4107X2U Inherit from COG: Exonuclease-like protein OXB_2482 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) OXB_2483 ENOG4105BZU Histidine kinase OXB_2484 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) OXB_2485 ENOG4105DVT helicase OXB_2487 ENOG410890F Dynamin family OXB_2488 ENOG4105KHC sulfurtransferase OXB_2490 ENOG41081VK Ribonuclease OXB_2495 ENOG4108IYU L-aspartate oxidase OXB_2496 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase OXB_2497 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) OXB_2498 ENOG4105CGZ zinc metallopeptidase OXB_2502 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) OXB_2503 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) OXB_2509 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer OXB_2512 ENOG4105CEY Amp-dependent synthetase and ligase OXB_2515 ENOG4105CJ1 ABC, transporter OXB_2518 ENOG4105C5H ABC transporter OXB_2521 ENOG4107YX5 Pfam:DUF548 OXB_2523 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) OXB_2524 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) OXB_2525 ENOG4108RCR degv family OXB_2526 ENOG41090WU lipolytic protein G-D-S-L family OXB_2528 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) OXB_2529 ENOG4105E0X reductase OXB_2530 ENOG4105VSD UPF0346 protein OXB_2531 ENOG4105D3A purine nucleoside phosphorylase DeoD-type OXB_2533 ENOG4107QRP cobalamin biosynthesis protein CobW OXB_2534 ENOG4105K4I Scp-like extracellular OXB_2535 ENOG4105E1K spore germination protein OXB_2540 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) OXB_2541 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 OXB_2542 ENOG4105C7S Dehydrogenase OXB_2544 ENOG4105GMT ATPase associated with various cellular activities aaa_5 OXB_2545 ENOG4107T89 von Willebrand factor, type A OXB_2546 ENOG4105CDW Resistance protein OXB_2550 ENOG4105VEQ Cold shock protein OXB_2552 ENOG4105C5H ABC transporter OXB_2554 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein OXB_2557 ENOG4105FDK ABC transporter OXB_2564 ENOG4108Q5U germination protein, ger(x)c family OXB_2566 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer OXB_2568 ENOG4108RCF TRANSCRIPTIONal OXB_2571 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein OXB_2573 ENOG4105NTK Transcriptional repressor Mpra OXB_2574 ENOG4105C5X domain protein OXB_2575 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) OXB_2576 ENOG4107Y9U Membrane OXB_2580 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) OXB_2581 ENOG4108JB9 formate dehydrogenase OXB_2587 ENOG4105VRS hydrolase family 18 OXB_2595 ENOG4105BZU Histidine kinase OXB_2596 ENOG4105DPZ Two component transcriptional regulator (Winged helix family OXB_2598 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) OXB_2599 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) OXB_2600 ENOG4105W8X HesB YadR YfhF-family protein OXB_2601 ENOG4105CEY Amp-dependent synthetase and ligase OXB_2602 ENOG4105CHR reductase OXB_2604 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) OXB_2607 ENOG4105C32 Amino acid ABC transporter (Permease) OXB_2608 ENOG4108IV0 ABC, transporter OXB_2609 ENOG4105C0Z ABC transporter OXB_2611 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) OXB_2612 ENOG4108Z7G MaoC domain protein dehydratase OXB_2616 ENOG41061ZR Transcriptional regulator OXB_2617 ENOG4105MI2 OXB_2619 ENOG4108I0Z Aconitate hydratase OXB_2625 ENOG4108KF3 Electron transport protein SCO1 SenC OXB_2631 ENOG4105XXY Thioredoxin OXB_2632 ENOG4107QIV Cytochrome c biogenesis protein OXB_2634 ENOG4105C7B Threonine dehydratase OXB_2636 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) OXB_2637 ENOG4105CBP Major Facilitator OXB_2640 ENOG4105BZU Histidine kinase OXB_2643 ENOG4105CFI type iii restriction protein res subunit OXB_2644 ENOG4105M6F mutator MutT protein OXB_2645 ENOG4105C5I Dehydrogenase OXB_2653 ENOG4105E2S oxidase) subunit II OXB_2654 ENOG4105BZ9 Cytochrome C oxidase, subunit I OXB_2656 ENOG41060D1 Quinol oxidase OXB_2659 ENOG4105CDU Replicative dna helicase OXB_2661 ENOG4108SHJ s-layer protein OXB_2665 ENOG4105JVQ RNA Polymerase OXB_2666 ENOG4107BJW polysaccharide deacetylase OXB_2667 ENOG4105EXC Acyl-transferase OXB_2668 ENOG4105F87 Dehydratase OXB_2669 ENOG4105EEM helicase OXB_2671 ENOG4107R34 abc transporter permease protein OXB_2672 ENOG4105C19 ABC transporter OXB_2673 ENOG41087PP glycosyltransferase MGT family OXB_2674 ENOG41067QW Transcriptional regulator OXB_2678 ENOG4108RPX mosc domain containing protein OXB_2682 ENOG4107F3J Amp-dependent synthetase and ligase OXB_2683 ENOG4107ZYJ bioY protein OXB_2685 ENOG4108QMY dioxygenase OXB_2688 ENOG4108IIH CoA-transferase subunit B OXB_2689 ENOG4105D6N CoA-transferase, subunit a OXB_2691 ENOG4105NI3 Protein of unknown function (DUF3237) OXB_2693 ENOG4107HP6 Transcriptional regulator OXB_2695 ENOG4105C94 Transporter OXB_2697 ENOG4105BZU Histidine kinase OXB_2700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_2712 ENOG4105CHH sulfate transporter OXB_2713 ENOG4108QCI YvbH-like oligomerisation region OXB_2715 ENOG4108IXY short-chain dehydrogenase reductase OXB_2716 ENOG41069FQ Metallo-beta-lactamase superfamily OXB_2717 ENOG4105II7 pyrroline-5-carboxylate reductase OXB_2718 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase OXB_2719 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) OXB_2720 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) OXB_2721 ENOG4108V3W Chemotaxis protein, CheW OXB_2722 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) OXB_2723 ENOG4108HNZ carboxyl transferase OXB_2724 ENOG4108ZVT methylmalonyl-coA epimerase OXB_2725 ENOG4108Y6J UPF0403 protein OXB_2726 ENOG4105DJT lAO AO transport system ATPase OXB_2727 ENOG4105D5P Methylmalonyl-coA mutase OXB_2728 ENOG4105CMN Methylmalonyl-coA mutase OXB_2729 ENOG4105C7S Dehydrogenase OXB_2730 ENOG4105CPP Dehydrogenase, E1 component OXB_2733 ENOG4107RDP Dehydrogenase OXB_2734 ENOG4108JUB Transcriptional regulator OXB_2735 ENOG4106CCJ Protein of unknown function (DUF2627) OXB_2736 ENOG4108QXE glycerophosphoryl diester phosphodiesterase OXB_2739 ENOG4105S1Z Stage IV sporulation protein B OXB_2740 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) OXB_2742 ENOG4105DX0 Hemolysin A OXB_2743 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) OXB_2744 ENOG4105CTB Polyprenyl synthetase OXB_2745 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) OXB_2746 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) OXB_2747 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) OXB_2748 ENOG4105M7K Involved in the transcription termination process (By similarity) OXB_2749 ENOG4108ZSR alkaline shock protein OXB_2750 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase OXB_2757 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) OXB_2758 ENOG4105DC7 peptidase M24 OXB_2760 ENOG4105CBJ Metal-dependent enzyme OXB_2762 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) OXB_2764 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) OXB_2765 ENOG4105WZW rhodanese family OXB_2768 ENOG4108KF8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) OXB_2769 ENOG4108Z7G MaoC domain protein dehydratase OXB_2770 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) OXB_2771 ENOG4107RSM transcriptional regulator OXB_2772 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region OXB_2773 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) OXB_2774 ENOG4105CPC Aldo Keto reductase OXB_2775 ENOG4105ETE Transcriptional regulator (LacI family OXB_2779 ENOG4107SG5 Dehydrogenase OXB_2785 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit OXB_2786 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_2787 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter OXB_2788 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit OXB_2792 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) OXB_2793 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase OXB_2794 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F OXB_2795 ENOG41073TP transcriptional regulator OXB_2796 ENOG4105FF2 Type I DHQase OXB_2797 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor OXB_2798 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor OXB_2799 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) OXB_2800 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) OXB_2805 ENOG4106855 Competence protein OXB_2807 ENOG4107Y9E nuclease OXB_2823 ENOG4105MFU Protein of unknown function (DUF2634) OXB_2847 ENOG4105IG6 Phage terminase, large subunit OXB_2848 ENOG4108TFU terminase (Small subunit) OXB_2857 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) OXB_2862 ENOG4108UUM single-stranded DNA-binding protein OXB_2872 ENOG4106CVF DNA replication protein OXB_2891 ENOG4105VTR Integrase OXB_2895 ENOG4105C5X domain protein OXB_2898 ENOG4105E0M Sulfatase OXB_2900 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase OXB_2901 ENOG4105WDJ 50S ribosomal protein L33 OXB_2904 ENOG4107RF6 penicillin-binding protein OXB_2906 ENOG4105SXS Protein of unknown function (DUF456) OXB_2910 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) OXB_2911 ENOG4108U5J '-nucleotidase OXB_2912 ENOG4105N80 Ferric uptake regulator, Fur family OXB_2914 ENOG4105FDK ABC transporter OXB_2916 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) OXB_2923 ENOG4105C8J )-transporter OXB_2924 ENOG4105EW9 transcriptional regulator AsnC family OXB_2925 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) OXB_2926 ENOG4105EGD dinuclear metal center protein, YbgI family OXB_2929 ENOG4105C1G acyl-Coa dehydrogenase OXB_2931 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OXB_2932 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) OXB_2933 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) OXB_2935 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) OXB_2936 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) OXB_2937 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) OXB_2939 ENOG4107YR5 Diacylglycerol kinase OXB_2940 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) OXB_2941 ENOG4105CTJ Metal Dependent Phosphohydrolase OXB_2942 ENOG4105C9A Phoh family OXB_2946 ENOG4105DI5 UPF0365 protein OXB_2947 ENOG4105F7J membrane-bound serine protease OXB_2948 ENOG4105VCC 30S ribosomal protein S21 OXB_2949 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) OXB_2952 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) OXB_2957 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) OXB_2985 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) OXB_3008 ENOG4105CDU Replicative dna helicase OXB_3021 ENOG4108C33 Resolvase OXB_3024 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) OXB_3025 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) OXB_3026 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) OXB_3027 ENOG4105CFG Acts as a chaperone (By similarity) OXB_3028 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ OXB_3029 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) OXB_3030 ENOG4105CSA Coproporphyrinogen iii oxidase OXB_3031 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) OXB_3033 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) OXB_3034 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) OXB_3035 ENOG4105TQK DNA polymerase iii, delta' subunit OXB_3037 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 OXB_3038 ENOG4108UK2 deaminase OXB_3040 ENOG4105DXX methyltransferase OXB_3042 ENOG4108WF2 Metal Dependent Phosphohydrolase OXB_3043 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) OXB_3044 ENOG410812S Rna-binding protein OXB_3045 ENOG4105E2X shikimate dehydrogenase OXB_3046 ENOG4105CQW ribosome biogenesis GTPase YqeH OXB_3047 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase OXB_3048 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) OXB_3049 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) OXB_3051 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) OXB_3053 ENOG4108VQJ O-methyltransferase OXB_3054 ENOG4105HHA aminodeoxychorismate lyase OXB_3055 ENOG4105VPH UPF0473 protein OXB_3056 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) OXB_3057 ENOG4105VBH UPF0297 protein OXB_3058 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) OXB_3059 ENOG4105C7H Helicase, RecD TraA family OXB_3061 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) OXB_3062 ENOG4105C3J Cysteine desulfurase OXB_3064 ENOG4105D1H recombination factor protein RarA OXB_3065 ENOG4107R88 Chemotaxis protein (CheV) OXB_3068 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) OXB_3070 ENOG4105CUZ uba thif-type nad fad binding protein OXB_3071 ENOG4105C9M aspartyl-trna synthetase OXB_3072 ENOG4105CUT histidyl-tRNA synthetase OXB_3074 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase OXB_3076 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) OXB_3077 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) OXB_3078 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) OXB_3079 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) OXB_3080 ENOG41067VP Protein of unknown function (DUF1049) OXB_3081 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) OXB_3083 ENOG4105CKP Polysaccharide Biosynthesis Protein OXB_3084 ENOG4108QG2 Membrane OXB_3085 ENOG4105VIE preprotein translocase, subunit YajC OXB_3086 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) OXB_3087 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) OXB_3089 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) OXB_3090 ENOG4105CDY transcriptional regulatory protein OXB_3093 ENOG4105CQC Prephenate dehydratase OXB_3094 ENOG41090I5 UPF0735 ACT domain-containing protein OXB_3095 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control OXB_3098 ENOG4105K46 50S ribosomal protein l27 OXB_3099 ENOG4105X36 (ribosomal) protein OXB_3101 ENOG4105CH6 catalase OXB_3102 ENOG4105CH6 catalase OXB_3105 ENOG4107QMS site-determining protein OXB_3106 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) OXB_3108 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) OXB_3109 ENOG4105DFF Rod shape-determining protein mreb OXB_3110 ENOG4105W5Q DNA repair protein (RadC OXB_3111 ENOG4108Z03 MAF-like protein OXB_3113 ENOG4106A3R peptidase OXB_3118 ENOG4105D7Q type ii secretion system OXB_3119 ENOG4105CZX twitching motility protein OXB_3120 ENOG4107QHF type ii secretion system protein e OXB_3126 ENOG4105BZU Histidine kinase OXB_3127 ENOG4105BZU Histidine kinase OXB_3128 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase OXB_3129 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) OXB_3132 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) OXB_3133 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) OXB_3136 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase OXB_3137 ENOG4105D52 delta-aminolevulinic acid dehydratase OXB_3139 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) OXB_3141 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) OXB_3142 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) OXB_3143 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) OXB_3144 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) OXB_3145 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation OXB_3147 ENOG4108UX3 '-nucleotidase OXB_3148 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) OXB_3149 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) OXB_3150 ENOG4105C5I Dehydrogenase OXB_3151 ENOG4105JSC dimethylmenaquinone methyltransferase OXB_3152 ENOG4105E39 Enoyl-CoA hydratase OXB_3154 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) OXB_3155 ENOG4105C1G acyl-Coa dehydrogenase OXB_3156 ENOG4105C26 Dehydrogenase OXB_3159 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit OXB_3160 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter OXB_3162 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_3163 ENOG4105BZW Glycerate kinase OXB_3164 ENOG4105DRR Transcriptional regulator, GntR family OXB_3167 ENOG4105CHR reductase OXB_3169 ENOG4106S2D Transcriptional regulator OXB_3176 ENOG4105DVW rieske (2Fe-2S) OXB_3178 ENOG41090E6 transcriptional regulator MERR family OXB_3181 ENOG410900P UPF0336 protein OXB_3186 ENOG4105C8Q Methyl-accepting chemotaxis OXB_3191 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) OXB_3192 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) OXB_3195 ENOG4105PFC Transcriptional regulator OXB_3197 ENOG4105E33 succinate dehydrogenase OXB_3199 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit OXB_3201 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) OXB_3202 ENOG4105K63 Thioredoxin OXB_3203 ENOG4105C10 Electron transfer flavoprotein OXB_3204 ENOG4105BZJ Electron transfer flavoprotein OXB_3205 ENOG41060WC Enoyl-CoA hydratase OXB_3206 ENOG4107Z3H Transcriptional regulator, TetR family OXB_3207 ENOG4105CEY Amp-dependent synthetase and ligase OXB_3209 ENOG4105C98 muts2 protein OXB_3210 ENOG4105DCG PHP domain protein OXB_3213 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) OXB_3216 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) OXB_3217 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) OXB_3218 ENOG4105CHJ isochorismatase hydrolase OXB_3221 ENOG4108RWN rrna methyltransferase OXB_3222 ENOG41067MF small acid-soluble spore protein OXB_3223 ENOG4105DBV ornithine carbamoyltransferase OXB_3224 ENOG4105CN9 Peptidase m42 family protein OXB_3228 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) OXB_3229 ENOG4105C9U ATP-dependent DNA helicase RecQ OXB_3234 ENOG4108ZJ4 polysaccharide deacetylase OXB_3235 ENOG4105C72 UPF0176 protein OXB_3236 ENOG4105CAY ferredoxin--nadp reductase OXB_3241 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) OXB_3243 ENOG4105BZU Histidine kinase OXB_3244 ENOG4105CB2 alcohol dehydrogenase OXB_3250 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) OXB_3251 ENOG4105VJV 50s ribosomal protein L35 OXB_3252 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) OXB_3253 ENOG4105C22 threonyL-tRNA synthetase OXB_3256 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) OXB_3257 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase OXB_3258 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) OXB_3259 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) OXB_3260 ENOG4105C2M dna polymerase I OXB_3261 ENOG4105EPW hflc protein OXB_3262 ENOG4107QJR hflk protein OXB_3263 ENOG4105BZU Histidine kinase OXB_3264 ENOG4105DPZ Two component transcriptional regulator (Winged helix family OXB_3266 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) OXB_3267 ENOG4108HMX isocitrate dehydrogenase (NADP) OXB_3268 ENOG4105BZN citrate synthase OXB_3269 ENOG4108REF Sporulation integral membrane protein ytvi OXB_3270 ENOG4105FS0 cytoplasmic membrane protein OXB_3272 ENOG4105CTQ phosphohexokinase OXB_3273 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) OXB_3274 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) OXB_3275 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family OXB_3276 ENOG4105C0B DNA polymerase III (alpha subunit) OXB_3277 ENOG4105SFS phosphoesterase RecJ domain protein OXB_3280 ENOG4105E8R UPF0173 metal-dependent hydrolase OXB_3281 ENOG4105DC7 peptidase M24 OXB_3284 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) OXB_3286 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) OXB_3287 ENOG4105VK3 rdd domain containing protein OXB_3288 ENOG4105D07 Signal peptide peptidase, SppA OXB_3289 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) OXB_3291 ENOG4105FR1 rard protein OXB_3292 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) OXB_3294 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) OXB_3296 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) OXB_3298 ENOG4105C28 cystathionine OXB_3299 ENOG4105BZU Histidine kinase OXB_3300 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) OXB_3302 ENOG4105DQE DNA ligase OXB_3304 ENOG4105FDF Could be involved in DNA repair (By similarity) OXB_3306 ENOG4105DXI Major Facilitator superfamily OXB_3307 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) OXB_3308 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) OXB_3309 ENOG4105BZ4 penicillin-binding protein OXB_3311 ENOG4105F1V Acetoin utilization protein OXB_3312 ENOG4105W87 Cbs domain OXB_3313 ENOG4105DGU Histone deacetylase OXB_3314 ENOG4105ETE Transcriptional regulator (LacI family OXB_3315 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase OXB_3316 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) OXB_3319 ENOG4105DFU Cell wall formation (By similarity) OXB_3321 ENOG4108VDD TRNA binding domain protein OXB_3322 ENOG4108NKM UPF0354 protein OXB_3324 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) OXB_3328 ENOG4105C8F Beta-lactamase domain protein OXB_3329 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) OXB_3332 ENOG4105YW5 deoR family transcriptional regulator OXB_3335 ENOG4105C26 Dehydrogenase OXB_3337 ENOG4105CBX hi0933 family OXB_3338 ENOG4105C8T Leucyl-tRNA synthetase OXB_3339 ENOG4108IIH CoA-transferase subunit B OXB_3340 ENOG4105D6N CoA-transferase, subunit a OXB_3341 ENOG4105N5T Radical SAM Protein OXB_3343 ENOG4105DKW ABC transporter OXB_3344 ENOG410904N short-chain dehydrogenase reductase OXB_3354 ENOG4106F5Q Membrane OXB_3357 ENOG4105NX3 Membrane OXB_3358 ENOG4105VMP Transcriptional regulator OXB_3363 ENOG41069ER domain protein OXB_3364 ENOG4105DRR Transcriptional regulator, GntR family OXB_3367 ENOG4107RFY SbcCD D subunit OXB_3368 ENOG4105DSE periplasmic solute binding protein OXB_3369 ENOG4105CC5 ABC transporter OXB_3370 ENOG4105DIK (ABC) transporter OXB_3374 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) OXB_3375 ENOG4108RAV Conserved protein OXB_3378 ENOG4105CZM Major Facilitator OXB_3379 ENOG4107MII Sugar-specific transcriptional regulator TrmB OXB_3380 ENOG4105EU0 Major facilitator Superfamily OXB_3381 ENOG4108JYZ YitT family OXB_3387 ENOG4105DPN Oligoendopeptidase f OXB_3388 ENOG4105D01 (LipO)protein OXB_3389 ENOG4105D01 (LipO)protein OXB_3390 ENOG4108UMI ABC transporter, permease OXB_3391 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) OXB_3395 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) OXB_3396 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) OXB_3397 ENOG4108R6K riboflavin synthase, subunit alpha OXB_3401 ENOG4107SQ8 Glycine betaine OXB_3402 ENOG4108IJ7 Glycine betaine OXB_3403 ENOG4107HG4 Transcriptional regulator OXB_3404 ENOG4105C8Q Methyl-accepting chemotaxis OXB_3406 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_3407 ENOG4105BZU Histidine kinase OXB_3408 ENOG4108KF3 Electron transport protein SCO1 SenC OXB_3411 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs OXB_3414 ENOG4105CIH Imidazole acetol-phosphate transaminase OXB_3415 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase OXB_3416 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) OXB_3417 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase OXB_3418 ENOG4105ECC imidazole-glycerol-phosphate dehydratase OXB_3419 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) OXB_3420 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) OXB_3421 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) OXB_3422 ENOG4107RVV histidinol phosphate phosphatase, hisj family OXB_3424 ENOG4105JVQ RNA Polymerase OXB_3425 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase OXB_3433 ENOG4105CJ1 ABC, transporter OXB_3436 ENOG4105C26 Dehydrogenase OXB_3437 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) OXB_3438 ENOG4105C26 Dehydrogenase OXB_3447 ENOG4105CG6 trap dicarboxylate transporter dctm subunit OXB_3449 ENOG4105CH5 extracellular solute-binding protein, family 7 OXB_3453 ENOG4106P55 Transcriptional regulator OXB_3456 ENOG4105CDH Citrulline--aspartate ligase OXB_3457 ENOG4107R37 Glutamate dehydrogenase OXB_3459 ENOG4105VRS hydrolase family 18 OXB_3462 ENOG4108YBP pseudouridine synthase OXB_3465 ENOG4105C6K Malic enzyme OXB_3466 ENOG4108QY0 Membrane OXB_3468 ENOG4105FDT acyl-CoA dehydrogenase OXB_3469 ENOG4105CVG Homoserine O-transsuccinylase OXB_3471 ENOG4108UKS UPF0398 protein OXB_3473 ENOG4108Z86 Glutamine amidotransferase OXB_3477 ENOG4105FAA peptidase M23 OXB_3478 ENOG4108JQ1 Dehydrogenase OXB_3479 ENOG4105U0R haloacid dehalogenase-like hydrolase OXB_3480 ENOG4105M7V 2'-5' rna ligase OXB_3482 ENOG4105D7N magnesium and cobalt transport protein CorA OXB_3483 ENOG4106GRI small acid-soluble spore protein H OXB_3485 ENOG4105C8Q Methyl-accepting chemotaxis OXB_3487 ENOG4105DTQ mandelate racemase muconate lactonizing OXB_3488 ENOG4107QWE )-transporter OXB_3489 ENOG4105CH6 catalase OXB_3492 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_3494 ENOG4106YBV Methyl-accepting chemotaxis OXB_3496 ENOG4108PCN EamA-like transporter family OXB_3498 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase OXB_3499 ENOG4105C26 Dehydrogenase OXB_3500 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin OXB_3501 ENOG4105BZ1 (ABC) transporter OXB_3502 ENOG4105CFP Peptidase U32 OXB_3508 ENOG4105CK6 Two component transcriptional regulator (Winged helix family OXB_3509 ENOG4105BZU Histidine kinase OXB_3510 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) OXB_3511 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) OXB_3517 ENOG4105CE1 Ferrous iron transport protein b OXB_3521 ENOG4105CXN decarboxylase OXB_3522 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) OXB_3523 ENOG4105CYW agmatinase OXB_3527 ENOG4105EAB amino acid AbC transporter OXB_3528 ENOG4108HW4 amino acid AbC transporter OXB_3532 ENOG4107E6A Cytochrome p-450 OXB_3534 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) OXB_3535 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) OXB_3538 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) OXB_3539 ENOG4107QHM Sulfite reductase OXB_3540 ENOG4108JUB Transcriptional regulator OXB_3541 ENOG4108JPW Aminotransferase OXB_3542 ENOG4108HW3 (ABC) transporter OXB_3543 ENOG4105E5Q amino acid AbC transporter OXB_3544 ENOG4105CDA abc transporter atp-binding protein OXB_3545 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) OXB_3546 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein OXB_3547 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) OXB_3549 ENOG4107RIQ Sulfate adenylate transferase OXB_3550 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) OXB_3555 ENOG4105CAS nag kinase OXB_3556 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) OXB_3557 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase OXB_3558 ENOG4105CHR reductase OXB_3564 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) OXB_3567 ENOG4105K7K Transcriptional regulator OXB_3571 ENOG4107XJU UPF0178 protein OXB_3573 ENOG4105DEN Luciferase family OXB_3574 ENOG41065KQ synthase OXB_3576 ENOG4105DFD Na H antiporter OXB_3577 ENOG4107Y9E nuclease OXB_3578 ENOG4105G6Z alkaline phosphatase OXB_3579 ENOG41084I6 Protein CrcB homolog OXB_3580 ENOG4105WMR Protein CrcB homolog OXB_3581 ENOG4105C4R Atp-dependent dna helicase OXB_3585 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer OXB_3586 ENOG4105E8V Alpha Beta Hydrolase Fold protein OXB_3587 ENOG4108Z0R Transferase