locus-tag	class	description
H4O14_00010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4O14_00025	COG0187	DNA topoisomerase II activity
H4O14_00035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4O14_00040	COG2501	S4 domain
H4O14_00045	COG0592	DNA-directed DNA polymerase activity
H4O14_00050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H4O14_00060	COG0594	ribonuclease P activity
H4O14_00065	COG0706	membrane insertase activity
H4O14_00070	COG1847	R3H domain protein
H4O14_00075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4O14_00080	COG0445	tRNA wobble uridine modification
H4O14_00085	COG0357	Ribosomal RNA small subunit methyltransferase G
H4O14_00095	COG1192	Involved in chromosome partitioning
H4O14_00100	COG1475	DNA binding
H4O14_00105	COG1811	Na channel or pump
H4O14_00115	COG0668	transmembrane transport
H4O14_00120	COG4481	Protein conserved in bacteria
H4O14_00125	COG0012	GTP binding
H4O14_00130	COG0360	Binds together with S18 to 16S ribosomal RNA
H4O14_00135	COG0629	single-stranded DNA binding
H4O14_00145	COG4241	membrane
H4O14_00150	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H4O14_00155	COG0359	binds to the 23S rRNA
H4O14_00160	COG0305	Participates in initiation and elongation during chromosome replication
H4O14_00165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4O14_00175	COG0739	heme binding
H4O14_00180	COG0745	RESPONSE REGULATOR receiver
H4O14_00185	COG5002	protein histidine kinase activity
H4O14_00195	COG4853	Protein conserved in bacteria
H4O14_00200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H4O14_00205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_00290	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4O14_00305	COG0577	efflux transmembrane transporter activity
H4O14_00310	COG1136	(ABC) transporter
H4O14_00315	COG2205	protein histidine kinase activity
H4O14_00320	COG0745	RESPONSE REGULATOR receiver
H4O14_00325	COG2814	Major facilitator Superfamily
H4O14_00330	COG1846	Transcriptional regulator
H4O14_00335	COG0326	Molecular chaperone. Has ATPase activity
H4O14_00340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4O14_00350	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4O14_00355	COG3842	ATPase activity
H4O14_00365	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4O14_00375	COG2094	Belongs to the DNA glycosylase MPG family
H4O14_00390	COG5002	protein histidine kinase activity
H4O14_00400	COG4842	Belongs to the WXG100 family
H4O14_00405	COG5417	Belongs to the EsaB family
H4O14_00410	COG4499	WXG100 protein secretion system (Wss), protein YukC
H4O14_00415	COG1674	ftsk spoiiie
H4O14_00415	COG0433	COG0433 Predicted ATPase
H4O14_00420	COG1511	domain protein
H4O14_00430	COG1187	pseudouridine synthase activity
H4O14_00470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4O14_00475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_00495	COG4895	conserved protein (DUF2196)
H4O14_00515	COG3173	Aminoglycoside phosphotransferase
H4O14_00520	COG0488	(ABC) transporter
H4O14_00530	COG0551	DNA topoisomerase type I activity
H4O14_00530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4O14_00540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4O14_00545	COG1845	cytochrome c oxidase, subunit III
H4O14_00550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4O14_00565	COG3314	Sporulation integral membrane protein YlbJ
H4O14_00570	COG0778	Nitroreductase
H4O14_00580	COG1522	sequence-specific DNA binding
H4O14_00590	COG2059	Chromate
H4O14_00595	COG2059	Chromate
H4O14_00600	COG1404	Belongs to the peptidase S8 family
H4O14_00610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_00615	COG0351	phosphomethylpyrimidine kinase
H4O14_00620	COG1309	transcriptional regulator
H4O14_00640	COG1216	Glycosyl transferase, family 2
H4O14_00645	COG0300	oxidoreductase activity
H4O14_00675	COG2363	Small membrane protein
H4O14_00695	COG3253	May function as heme-dependent peroxidase
H4O14_00700	COG0280	phosphate acetyltransferase
H4O14_00705	COG1266	CAAX protease self-immunity
H4O14_00720	COG4844	belongs to the
H4O14_00725	COG1078	dGTPase activity
H4O14_00730	COG3465	dGTPase activity
H4O14_00740	COG1994	Peptidase M50
H4O14_00750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_00755	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H4O14_00760	COG0010	Belongs to the arginase family
H4O14_00765	COG4506	Protein conserved in bacteria
H4O14_00770	COG0018	arginyl-trna synthetase
H4O14_00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O14_00785	COG0247	lactate metabolic process
H4O14_00785	COG2181	nitrate reductase activity
H4O14_00790	COG0183	Belongs to the thiolase family
H4O14_00795	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_00800	COG1960	acyl-CoA dehydrogenase activity
H4O14_00805	COG1960	acyl-CoA dehydrogenase activity
H4O14_00815	COG1703	isobutyryl-CoA mutase activity
H4O14_00815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_00815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_00825	COG2310	stress, protein
H4O14_00830	COG2310	stress, protein
H4O14_00865	COG3853	Toxic anion resistance protein (TelA)
H4O14_00880	COG4821	SIS domain
H4O14_00885	COG2204	response regulator
H4O14_00890	COG0191	fructose-bisphosphate aldolase activity
H4O14_00895	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4O14_00900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4O14_00905	COG1494	fructose-1,6-bisphosphatase
H4O14_00910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4O14_00915	COG0254	rRNA binding
H4O14_00920	COG1435	thymidine kinase activity
H4O14_00930	COG0789	Transcriptional regulator
H4O14_00935	COG0346	lactoylglutathione lyase activity
H4O14_00940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4O14_00945	COG2890	protein-(glutamine-N5) methyltransferase activity
H4O14_00960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H4O14_00965	COG0009	L-threonylcarbamoyladenylate synthase
H4O14_00970	COG1971	Probably functions as a manganese efflux pump
H4O14_00980	COG0698	ribose 5-phosphate isomerase
H4O14_00990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4O14_00995	COG1968	undecaprenyl-diphosphatase activity
H4O14_01000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4O14_01005	COG1404	Belongs to the peptidase S8 family
H4O14_01020	COG0356	it plays a direct role in the translocation of protons across the membrane
H4O14_01035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4O14_01040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4O14_01045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H4O14_01050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4O14_01055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4O14_01060	COG0477	Major facilitator Superfamily
H4O14_01070	COG2972	Histidine kinase
H4O14_01075	COG2207	Transcriptional regulator
H4O14_01075	COG4753	response regulator
H4O14_01080	COG4213	ABC transporter substrate-binding protein
H4O14_01085	COG1129	ABC transporter
H4O14_01090	COG4214	carbohydrate transport
H4O14_01095	COG0840	transmembrane signaling receptor activity
H4O14_01105	COG0723	plastoquinol--plastocyanin reductase activity
H4O14_01105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_01110	COG0673	inositol 2-dehydrogenase activity
H4O14_01120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4O14_01125	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4O14_01130	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4O14_01150	COG0839	Belongs to the complex I subunit 6 family
H4O14_01155	COG0713	ATP synthesis coupled electron transport
H4O14_01160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4O14_01170	COG1007	ATP synthesis coupled electron transport
H4O14_01175	COG4836	Membrane
H4O14_01185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4O14_01195	COG2385	sporulation resulting in formation of a cellular spore
H4O14_01205	COG1247	-acetyltransferase
H4O14_01215	COG0739	heme binding
H4O14_01225	COG1609	Transcriptional regulator
H4O14_01230	COG1077	Cell shape determining protein MreB Mrl
H4O14_01235	COG4786	Flagellar basal body rod
H4O14_01240	COG4786	Flagellar basal body rod
H4O14_01280	COG0629	single-stranded DNA binding
H4O14_01290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4O14_01295	COG4715	Zinc finger, swim domain protein
H4O14_01305	COG3944	biosynthesis protein
H4O14_01310	COG0489	protein tyrosine kinase activity
H4O14_01315	COG4464	protein tyrosine phosphatase activity
H4O14_01320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4O14_01325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O14_01330	COG2327	Polysaccharide pyruvyl transferase
H4O14_01345	COG1216	Glycosyl transferase, family 2
H4O14_01345	COG1442	glycosyl transferase family 8
H4O14_01360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4O14_01370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H4O14_01370	COG0662	Cupin 2, conserved barrel domain protein
H4O14_01375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4O14_01380	COG1482	cell wall glycoprotein biosynthetic process
H4O14_01385	COG1737	Transcriptional regulator
H4O14_01390	COG1486	melibiose metabolic process
H4O14_01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_01395	COG2190	(PTS) system
H4O14_01395	COG1263	PTS System
H4O14_01425	COG0653	protein targeting
H4O14_01430	COG1316	TRANSCRIPTIONal
H4O14_01440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_01455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4O14_01460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4O14_01465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H4O14_01485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4O14_01490	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_01500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4O14_01505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4O14_01520	COG0673	inositol 2-dehydrogenase activity
H4O14_01540	COG2247	cell wall binding repeat
H4O14_01540	COG2385	sporulation resulting in formation of a cellular spore
H4O14_01550	COG1316	TRANSCRIPTIONal
H4O14_01555	COG1739	Uncharacterized protein family UPF0029
H4O14_01560	COG4585	Histidine kinase
H4O14_01565	COG2197	response regulator
H4O14_01570	COG1307	EDD domain protein, DegV family
H4O14_01580	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H4O14_01590	COG1040	competence protein
H4O14_01605	COG3418	PFAM FlgN family protein
H4O14_01610	COG1256	bacterial-type flagellum assembly
H4O14_01610	COG4786	Flagellar basal body rod
H4O14_01615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4O14_01625	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H4O14_01630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H4O14_01635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4O14_01640	COG0463	Glycosyl transferase, family 2
H4O14_01665	COG1334	flagellar protein FlaG
H4O14_01670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4O14_01675	COG1516	flagellar protein fliS
H4O14_01690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4O14_01695	COG0653	protein targeting
H4O14_01705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_01715	COG2884	Cell division ATP-binding protein ftsE
H4O14_01720	COG2177	Part of the ABC transporter FtsEX involved in
H4O14_01725	COG3883	PFAM NLP P60 protein
H4O14_01725	COG0791	NLP P60 protein
H4O14_01730	COG0793	Belongs to the peptidase S41A family
H4O14_01730	COG3409	Peptidoglycan-binding domain 1 protein
H4O14_01740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_01745	COG0789	Transcriptional regulator
H4O14_01760	COG0109	protoheme IX farnesyltransferase activity
H4O14_01775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_01780	COG4605	iron ion homeostasis
H4O14_01785	COG4604	ABC transporter, ATP-binding protein
H4O14_01790	COG4607	ABC-type enterochelin transport system periplasmic component
H4O14_01795	COG1136	(ABC) transporter
H4O14_01800	COG0577	efflux transmembrane transporter activity
H4O14_01805	COG0745	RESPONSE REGULATOR receiver
H4O14_01810	COG5002	protein histidine kinase activity
H4O14_01810	COG3850	Histidine kinase
H4O14_01815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4O14_01820	COG4897	Protein conserved in bacteria
H4O14_01825	COG0556	nucleotide-excision repair
H4O14_01830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4O14_01840	COG3595	metallopeptidase activity
H4O14_01850	COG1950	PFAM Membrane protein of
H4O14_01855	COG1970	mechanosensitive ion channel activity
H4O14_01860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4O14_01875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4O14_01880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H4O14_01885	COG0546	phosphoglycolate phosphatase activity
H4O14_01890	COG0110	maltose O-acetyltransferase activity
H4O14_01895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H4O14_01900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4O14_01905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4O14_01910	COG0131	Imidazoleglycerol-phosphate dehydratase
H4O14_01915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4O14_01920	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4O14_01925	COG0107	imidazoleglycerol-phosphate synthase activity
H4O14_01930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4O14_01930	COG0140	phosphoribosyl-ATP diphosphatase activity
H4O14_01935	COG0457	Tetratricopeptide repeat
H4O14_01940	COG0492	ferredoxin-NADP+ reductase activity
H4O14_01945	COG1051	belongs to the nudix hydrolase family
H4O14_01950	COG1660	Displays ATPase and GTPase activities
H4O14_01955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H4O14_01960	COG1481	regulation of sporulation
H4O14_01965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4O14_01970	COG0740	serine-type endopeptidase activity
H4O14_02090	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4O14_02105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4O14_02125	COG0148	phosphopyruvate hydratase activity
H4O14_02145	COG0697	spore germination
H4O14_02150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4O14_02155	COG1647	Serine aminopeptidase, S33
H4O14_02160	COG0557	exoribonuclease II activity
H4O14_02165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4O14_02175	COG4974	Belongs to the 'phage' integrase family
H4O14_02270	COG0629	single-stranded DNA binding
H4O14_02290	COG0582	viral genome integration into host DNA
H4O14_02420	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_02465	COG1388	LysM domain
H4O14_02475	COG2608	mercury ion transmembrane transporter activity
H4O14_02480	COG2217	Heavy metal translocating P-type atpase
H4O14_02490	COG0805	protein transport
H4O14_02495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4O14_02510	COG1349	DNA-binding transcription factor activity
H4O14_02515	COG0833	amino acid
H4O14_02535	COG1309	transcriptional regulator
H4O14_02540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4O14_02550	COG1131	(ABC) transporter
H4O14_02555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4O14_02570	COG0753	catalase activity
H4O14_02585	COG0640	Transcriptional regulator
H4O14_02590	COG0004	ammonium transporteR
H4O14_02600	COG2176	DNA-directed DNA polymerase activity
H4O14_02605	COG1597	lipid kinase activity
H4O14_02630	COG2856	Zn peptidase
H4O14_02640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_02660	COG0583	DNA-binding transcription factor activity
H4O14_02665	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_02675	COG2814	Major facilitator Superfamily
H4O14_02680	COG1846	Transcriptional regulator
H4O14_02695	COG1737	Transcriptional regulator
H4O14_02700	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H4O14_02705	COG1070	Carbohydrate kinase
H4O14_02710	COG0205	6-phosphofructokinase activity
H4O14_02720	COG0741	lytic transglycosylase activity
H4O14_02730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_02735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_02740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_02745	COG1733	regulation of RNA biosynthetic process
H4O14_02755	COG1131	(ABC) transporter
H4O14_02760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4O14_02765	COG0598	Magnesium transport protein CorA
H4O14_02775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_02785	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4O14_02790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4O14_02800	COG5002	protein histidine kinase activity
H4O14_02830	COG0114	fumarate hydratase activity
H4O14_02835	COG2205	protein histidine kinase activity
H4O14_02835	COG2770	Histidine kinase
H4O14_02840	COG0745	RESPONSE REGULATOR receiver
H4O14_02845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_02850	COG2814	Major facilitator Superfamily
H4O14_02855	COG1309	transcriptional regulator
H4O14_02860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4O14_02870	COG2986	histidine ammonia-lyase
H4O14_02875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H4O14_02880	COG1228	amidohydrolase
H4O14_02885	COG0010	Belongs to the arginase family
H4O14_02890	COG2851	Citrate transporter
H4O14_02900	COG1846	Transcriptional regulator
H4O14_02900	COG0456	acetyltransferase
H4O14_02905	COG4565	transcriptional regulatory protein
H4O14_02910	COG3290	protein histidine kinase activity
H4O14_02935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4O14_02940	COG2011	ABC-type metal ion transport system permease component
H4O14_02945	COG1464	Belongs to the NlpA lipoprotein family
H4O14_02955	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_02960	COG4978	Transcriptional regulator
H4O14_02960	COG0789	Transcriptional regulator
H4O14_02990	COG0454	-acetyltransferase
H4O14_03015	COG2076	Multidrug Resistance protein
H4O14_03020	COG2076	Multidrug Resistance protein
H4O14_03030	COG1686	Belongs to the peptidase S11 family
H4O14_03035	COG0531	amino acid
H4O14_03060	COG0531	amino acid
H4O14_03065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4O14_03080	COG1301	dicarboxylic acid transport
H4O14_03085	COG5002	protein histidine kinase activity
H4O14_03090	COG0745	RESPONSE REGULATOR receiver
H4O14_03095	COG0569	domain protein
H4O14_03100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4O14_03110	COG0367	asparagine synthase
H4O14_03125	COG5002	protein histidine kinase activity
H4O14_03140	COG1960	acyl-CoA dehydrogenase activity
H4O14_03145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_03150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_03160	COG1120	ATPase activity
H4O14_03180	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4O14_03185	COG5577	PFAM Coat F domain
H4O14_03195	COG0506	proline dehydrogenase activity
H4O14_03200	COG2267	carboxylic ester hydrolase activity
H4O14_03210	COG1024	Enoyl-CoA hydratase
H4O14_03210	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_03215	COG0183	Belongs to the thiolase family
H4O14_03220	COG1960	acyl-CoA dehydrogenase activity
H4O14_03225	COG1393	Belongs to the ArsC family
H4O14_03230	COG0509	glycine decarboxylation via glycine cleavage system
H4O14_03240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H4O14_03245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_03255	COG2873	o-acetylhomoserine
H4O14_03260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4O14_03265	COG2011	ABC-type metal ion transport system permease component
H4O14_03270	COG1464	Belongs to the NlpA lipoprotein family
H4O14_03275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4O14_03285	COG0396	ATPase activity
H4O14_03290	COG0719	Fe-S assembly protein
H4O14_03295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4O14_03300	COG0822	iron-sulfur transferase activity
H4O14_03305	COG0719	Fe-S assembly protein
H4O14_03315	COG2814	Major facilitator Superfamily
H4O14_03320	COG1809	phosphosulfolactate synthase activity
H4O14_03325	COG0406	alpha-ribazole phosphatase activity
H4O14_03330	COG0697	spore germination
H4O14_03335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_03345	COG1801	Protein of unknown function DUF72
H4O14_03350	COG0730	response to heat
H4O14_03355	COG0737	Belongs to the 5'-nucleotidase family
H4O14_03360	COG3377	Domain of unknown function (DUF1805)
H4O14_03370	COG0733	neurotransmitter:sodium symporter activity
H4O14_03380	COG0739	heme binding
H4O14_03385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4O14_03395	COG4470	Protein conserved in bacteria
H4O14_03410	COG2200	EAL domain
H4O14_03410	COG3287	FIST C domain
H4O14_03410	COG2199	diguanylate cyclase activity
H4O14_03415	COG2445	Protein of unknown function DUF86
H4O14_03420	COG0647	UMP catabolic process
H4O14_03425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4O14_03430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_03435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4O14_03445	COG0460	homoserine dehydrogenase
H4O14_03450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4O14_03460	COG0823	Involved in the tonB-independent uptake of proteins
H4O14_03460	COG1506	peptidase
H4O14_03460	COG4946	Tricorn protease homolog
H4O14_03465	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H4O14_03470	COG4837	Protein of unknown function (DUF1462)
H4O14_03475	COG1252	NADH dehydrogenase
H4O14_03490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4O14_03495	COG0316	Belongs to the HesB IscA family
H4O14_03530	COG0492	ferredoxin-NADP+ reductase activity
H4O14_03535	COG1252	NADH dehydrogenase
H4O14_03555	COG3584	3D domain protein
H4O14_03565	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H4O14_03575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4O14_03580	COG2056	Na+-H+ antiporter family
H4O14_03595	COG1268	BioY protein
H4O14_03600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4O14_03605	COG3852	Histidine kinase
H4O14_03610	COG0697	spore germination
H4O14_03615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4O14_03620	COG0686	Belongs to the AlaDH PNT family
H4O14_03625	COG2508	Transcriptional regulator
H4O14_03625	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H4O14_03635	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_03655	COG1418	mRNA catabolic process
H4O14_03660	COG1011	Hydrolase
H4O14_03665	COG0398	Pfam SNARE associated Golgi protein
H4O14_03670	COG0789	Transcriptional regulator
H4O14_03675	COG1253	flavin adenine dinucleotide binding
H4O14_03680	COG0628	permease
H4O14_03690	COG1609	Transcriptional regulator
H4O14_03695	COG0243	molybdopterin cofactor binding
H4O14_03700	COG2368	4-hydroxyphenylacetate
H4O14_03710	COG5506	Protein of unknown function (DUF1694)
H4O14_03735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H4O14_03740	COG4989	oxidoreductase activity
H4O14_03750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4O14_03755	COG0726	polysaccharide deacetylase
H4O14_03760	COG1408	metallophosphoesterase
H4O14_03765	COG0656	L-ascorbic acid biosynthetic process
H4O14_03770	COG2207	Transcriptional regulator
H4O14_03785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H4O14_03790	COG0840	transmembrane signaling receptor activity
H4O14_03810	COG0142	geranyltranstransferase activity
H4O14_03820	COG4585	Histidine kinase
H4O14_03825	COG2197	response regulator
H4O14_03835	COG2133	pyrroloquinoline quinone binding
H4O14_03840	COG2050	protein possibly involved in aromatic compounds catabolism
H4O14_03845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_03855	COG1320	monovalent cation:proton antiporter activity
H4O14_03860	COG2212	antiporter activity
H4O14_03865	COG1863	multisubunit Na H antiporter MnhE subunit
H4O14_03870	COG0651	ATP synthesis coupled electron transport
H4O14_03875	COG1006	Multisubunit Na H antiporter MnhC subunit
H4O14_03880	COG2111	Na H antiporter
H4O14_03885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4O14_03885	COG2111	Na H antiporter
H4O14_03900	COG3011	Protein conserved in bacteria
H4O14_03905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_03910	COG2814	Major facilitator Superfamily
H4O14_03915	COG5018	Exonuclease
H4O14_03930	COG2032	superoxide dismutase activity
H4O14_03965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4O14_03975	COG2267	carboxylic ester hydrolase activity
H4O14_03980	COG1522	sequence-specific DNA binding
H4O14_03985	COG0436	Aminotransferase
H4O14_04005	COG1098	S1 RNA binding domain
H4O14_04010	COG2155	Conserved Protein
H4O14_04015	COG1979	alcohol dehydrogenase
H4O14_04055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4O14_04070	COG1253	flavin adenine dinucleotide binding
H4O14_04080	COG0366	Alpha amylase catalytic
H4O14_04085	COG0432	Pfam Uncharacterised protein family UPF0047
H4O14_04095	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H4O14_04105	COG2070	2-Nitropropane dioxygenase
H4O14_04110	COG3844	kynureninase activity
H4O14_04130	COG1823	symporter activity
H4O14_04145	COG1132	(ABC) transporter
H4O14_04150	COG1349	DNA-binding transcription factor activity
H4O14_04155	COG1105	Belongs to the carbohydrate kinase PfkB family
H4O14_04160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4O14_04160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4O14_04160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4O14_04175	COG2112	serine threonine protein kinase
H4O14_04180	COG1309	transcriptional regulator
H4O14_04185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4O14_04190	COG1285	pathogenesis
H4O14_04195	COG0673	inositol 2-dehydrogenase activity
H4O14_04200	COG2176	DNA-directed DNA polymerase activity
H4O14_04215	COG2259	Doxx family
H4O14_04220	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_04245	COG2814	Major facilitator Superfamily
H4O14_04250	COG1414	Transcriptional regulator
H4O14_04270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4O14_04290	COG1595	DNA-templated transcription, initiation
H4O14_04315	COG2385	sporulation resulting in formation of a cellular spore
H4O14_04325	COG1486	melibiose metabolic process
H4O14_04330	COG1447	Phosphotransferase system cellobiose-specific component IIA
H4O14_04335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_04340	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_04355	COG2310	stress, protein
H4O14_04360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4O14_04365	COG0492	ferredoxin-NADP+ reductase activity
H4O14_04375	COG5002	protein histidine kinase activity
H4O14_04380	COG4129	membrane
H4O14_04385	COG0730	response to heat
H4O14_04395	COG1388	LysM domain
H4O14_04395	COG3584	3D domain protein
H4O14_04420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_04435	COG1966	Carbon starvation protein
H4O14_04440	COG3279	Response regulator of the LytR AlgR family
H4O14_04445	COG3275	phosphorelay sensor kinase activity
H4O14_04475	COG2202	Pas domain
H4O14_04475	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_04480	COG3773	Cell wall hydrolase
H4O14_04485	COG2132	Multicopper oxidase
H4O14_04490	COG0277	FAD linked oxidase domain protein
H4O14_04500	COG1131	(ABC) transporter
H4O14_04505	COG1309	transcriptional regulator
H4O14_04510	COG0574	Belongs to the PEP-utilizing enzyme family
H4O14_04510	COG3848	Pyruvate phosphate dikinase
H4O14_04515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4O14_04540	COG2318	DinB family
H4O14_04545	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_04560	COG1247	-acetyltransferase
H4O14_04565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O14_04575	COG3859	Proton-coupled thiamine transporter YuaJ
H4O14_04585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4O14_04590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_04595	COG1116	anion transmembrane transporter activity
H4O14_04725	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H4O14_04730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H4O14_04735	COG0297	glycogen (starch) synthase activity
H4O14_04740	COG0058	SHG alpha-glucan phosphorylase activity
H4O14_04755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4O14_04760	COG1575	Belongs to the MenA family. Type 1 subfamily
H4O14_04765	COG1169	isochorismate synthase
H4O14_04770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H4O14_04775	COG0596	Alpha beta hydrolase
H4O14_04780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H4O14_04785	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_04790	COG4948	Mandelate Racemase Muconate Lactonizing
H4O14_04795	COG0803	Belongs to the bacterial solute-binding protein 9 family
H4O14_04800	COG1121	(ABC) transporter
H4O14_04805	COG1321	iron dependent repressor
H4O14_04805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4O14_04810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4O14_04820	COG1294	oxidase, subunit
H4O14_04825	COG1271	oxidase subunit
H4O14_04835	COG0523	cobalamin synthesis protein
H4O14_04845	COG0523	cobalamin synthesis protein
H4O14_04850	COG0288	reversible hydration of carbon dioxide
H4O14_04855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H4O14_04865	COG0788	formyltetrahydrofolate deformylase activity
H4O14_04885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4O14_04890	COG1469	GTP cyclohydrolase I activity
H4O14_04895	COG0701	Predicted permease
H4O14_04915	COG0783	Belongs to the Dps family
H4O14_04930	COG0494	nUDIX hydrolase
H4O14_04940	COG1404	Belongs to the peptidase S8 family
H4O14_04945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4O14_04950	COG1116	anion transmembrane transporter activity
H4O14_04955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_04960	COG1506	peptidase
H4O14_04970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H4O14_04975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4O14_04980	COG0367	asparagine synthase
H4O14_04985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4O14_04985	COG0438	transferase activity, transferring glycosyl groups
H4O14_04990	COG0671	phosphoesterase, PA-phosphatase related
H4O14_04995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4O14_05000	COG2267	carboxylic ester hydrolase activity
H4O14_05010	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H4O14_05015	COG1242	4 iron, 4 sulfur cluster binding
H4O14_05030	COG1725	Transcriptional regulator
H4O14_05035	COG1131	(ABC) transporter
H4O14_05045	COG1136	(ABC) transporter
H4O14_05050	COG0577	efflux transmembrane transporter activity
H4O14_05065	COG2814	Major facilitator Superfamily
H4O14_05075	COG0495	leucyl-tRNA aminoacylation
H4O14_05080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4O14_05095	COG2081	HI0933 family
H4O14_05100	COG2244	polysaccharide biosynthetic process
H4O14_05105	COG1187	pseudouridine synthase activity
H4O14_05110	COG1349	DNA-binding transcription factor activity
H4O14_05115	COG2252	PERMEase
H4O14_05120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4O14_05130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4O14_05135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H4O14_05140	COG1380	Effector of murein hydrolase LrgA
H4O14_05145	COG1346	cytolysis
H4O14_05155	COG1597	lipid kinase activity
H4O14_05160	COG1523	belongs to the glycosyl hydrolase 13 family
H4O14_05165	COG0510	thiamine kinase activity
H4O14_05175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4O14_05180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_05185	COG5584	Small secreted protein
H4O14_05190	COG1363	Peptidase, m42
H4O14_05195	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H4O14_05210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_05215	COG4848	Belongs to the UPF0354 family
H4O14_05220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4O14_05225	COG1674	ftsk spoiiie
H4O14_05230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4O14_05235	COG2309	aminopeptidase activity
H4O14_05240	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H4O14_05245	COG4980	gas vesicle protein
H4O14_05250	COG3118	belongs to the thioredoxin family
H4O14_05255	COG0849	cell division
H4O14_05260	COG1605	Chorismate mutase
H4O14_05260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H4O14_05265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O14_05305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4O14_05315	COG1086	Polysaccharide biosynthesis protein
H4O14_05325	COG1609	Transcriptional regulator
H4O14_05330	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4O14_05335	COG0517	IMP dehydrogenase activity
H4O14_05340	COG0454	-acetyltransferase
H4O14_05345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4O14_05355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4O14_05360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4O14_05365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4O14_05370	COG2199	diguanylate cyclase activity
H4O14_05370	COG2203	Gaf domain
H4O14_05375	COG0626	cystathionine gamma-synthase activity
H4O14_05380	COG1956	GAF domain-containing protein
H4O14_05385	COG1309	transcriptional regulator
H4O14_05390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H4O14_05395	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H4O14_05400	COG1114	Component of the transport system for branched-chain amino acids
H4O14_05405	COG1104	cysteine desulfurase activity
H4O14_05410	COG0301	tRNA thio-modification
H4O14_05425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4O14_05430	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H4O14_05435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4O14_05440	COG0616	signal peptide processing
H4O14_05445	COG1714	RDD family
H4O14_05455	COG3874	Sporulation protein YtfJ
H4O14_05460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H4O14_05465	COG0827	DNA restriction-modification system
H4O14_05470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H4O14_05475	COG1757	Na H antiporter
H4O14_05485	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4O14_05500	COG0165	Argininosuccinate lyase
H4O14_05515	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_05525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H4O14_05550	COG4109	DRTGG domain
H4O14_05560	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H4O14_05580	COG0587	DNA-directed DNA polymerase activity
H4O14_05585	COG0281	malic enzyme
H4O14_05590	COG1725	Transcriptional regulator
H4O14_05595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4O14_05600	COG0825	malonyl-CoA metabolic process
H4O14_05605	COG0205	6-phosphofructokinase activity
H4O14_05615	COG3030	protein affecting phage T7 exclusion by the F plasmid
H4O14_05620	COG0628	permease
H4O14_05630	COG0372	Belongs to the citrate synthase family
H4O14_05635	COG0538	isocitrate dehydrogenase activity
H4O14_05640	COG0039	L-malate dehydrogenase activity
H4O14_05650	COG0745	RESPONSE REGULATOR receiver
H4O14_05655	COG5002	protein histidine kinase activity
H4O14_05660	COG0330	HflC and HflK could
H4O14_05665	COG0330	HflC and HflK could
H4O14_05670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O14_05670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O14_05675	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4O14_05680	COG1971	Probably functions as a manganese efflux pump
H4O14_05685	COG0237	dephospho-CoA kinase activity
H4O14_05690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4O14_05695	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4O14_05705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4O14_05710	COG3611	Membrane attachment protein
H4O14_05715	COG1484	DNA-dependent DNA replication
H4O14_05725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4O14_05730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4O14_05740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4O14_05765	COG1363	Peptidase, m42
H4O14_05775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4O14_05780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4O14_05785	COG0072	phenylalanine-tRNA ligase activity
H4O14_05785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4O14_05790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O14_05800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4O14_05805	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4O14_05810	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H4O14_05815	COG1286	toxin biosynthetic process
H4O14_05820	COG1796	DNA polymerase
H4O14_05820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H4O14_05830	COG3766	membrane
H4O14_05835	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_05840	COG1309	transcriptional regulator
H4O14_05845	COG1024	Enoyl-CoA hydratase
H4O14_05850	COG2086	electron transfer activity
H4O14_05855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H4O14_05860	COG3118	belongs to the thioredoxin family
H4O14_05865	COG0322	excinuclease ABC activity
H4O14_05870	COG0527	aspartate kinase activity
H4O14_05875	COG1719	4-vinyl reductase, 4VR
H4O14_05880	COG2009	succinate dehydrogenase
H4O14_05885	COG1053	succinate dehydrogenase
H4O14_05890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4O14_05895	COG0824	Thioesterase
H4O14_05900	COG2197	response regulator
H4O14_05905	COG1846	Transcriptional regulator
H4O14_05915	COG5401	PFAM Sporulation and spore germination
H4O14_05920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4O14_05925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H4O14_05930	COG0622	Phosphoesterase
H4O14_05940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4O14_05945	COG0028	Belongs to the TPP enzyme family
H4O14_05950	COG0440	acetolactate synthase activity
H4O14_05955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4O14_05960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4O14_05965	COG0473	3-isopropylmalate dehydrogenase activity
H4O14_05970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H4O14_05975	COG0066	3-isopropylmalate dehydratase activity
H4O14_05980	COG0457	Tetratricopeptide repeat
H4O14_05980	COG1477	protein flavinylation
H4O14_05985	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4O14_05990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4O14_05995	COG1067	ATP-dependent peptidase activity
H4O14_05995	COG0470	DNA polymerase III
H4O14_06000	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4O14_06005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H4O14_06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4O14_06025	COG0181	hydroxymethylbilane synthase activity
H4O14_06035	COG0113	porphobilinogen synthase activity
H4O14_06040	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4O14_06055	COG1388	LysM domain
H4O14_06055	COG1388	LysM domain
H4O14_06060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_06070	COG0525	valine-tRNA ligase activity
H4O14_06075	COG0285	dihydrofolate synthase activity
H4O14_06110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4O14_06120	COG1459	type II secretion system
H4O14_06125	COG2165	general secretion pathway protein
H4O14_06130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H4O14_06160	COG2003	Belongs to the UPF0758 family
H4O14_06165	COG1077	Cell shape determining protein MreB Mrl
H4O14_06175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H4O14_06180	COG0850	regulation of cytokinetic process
H4O14_06185	COG2894	cell division
H4O14_06190	COG0739	heme binding
H4O14_06195	COG1994	Peptidase M50
H4O14_06200	COG1530	ribonuclease E activity
H4O14_06205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H4O14_06210	COG2868	ribosomal protein
H4O14_06220	COG3290	protein histidine kinase activity
H4O14_06230	COG4492	Belongs to the UPF0735 family
H4O14_06235	COG0077	Prephenate dehydratase
H4O14_06240	COG1827	regulation of RNA biosynthetic process
H4O14_06245	COG1104	cysteine desulfurase activity
H4O14_06250	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4O14_06255	COG0157	Belongs to the NadC ModD family
H4O14_06260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4O14_06280	COG0632	four-way junction helicase activity
H4O14_06285	COG2255	four-way junction helicase activity
H4O14_06295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H4O14_06305	COG1862	Preprotein translocase
H4O14_06315	COG2323	membrane
H4O14_06320	COG2244	polysaccharide biosynthetic process
H4O14_06330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4O14_06330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4O14_06335	COG5416	Lipopolysaccharide assembly protein A domain
H4O14_06340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4O14_06340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H4O14_06345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H4O14_06350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4O14_06355	COG1490	D-aminoacyl-tRNA deacylase activity
H4O14_06360	COG3103	Sh3 type 3 domain protein
H4O14_06360	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_06360	COG4991	sh3 domain protein
H4O14_06375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4O14_06385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4O14_06390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4O14_06395	COG2364	Membrane
H4O14_06400	COG1959	2 iron, 2 sulfur cluster binding
H4O14_06405	COG1104	cysteine desulfurase activity
H4O14_06420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4O14_06440	COG0628	permease
H4O14_06445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4O14_06450	COG4472	Bacterial protein of unknown function (DUF965)
H4O14_06455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4O14_06460	COG3906	Belongs to the UPF0473 family
H4O14_06465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4O14_06470	COG4122	O-methyltransferase activity
H4O14_06475	COG0826	peptidase U32
H4O14_06480	COG0826	peptidase U32
H4O14_06485	COG0572	uridine kinase
H4O14_06490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4O14_06495	COG0768	penicillin binding
H4O14_06510	COG2226	methyltransferase
H4O14_06515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4O14_06520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4O14_06525	COG0626	cystathionine gamma-synthase activity
H4O14_06535	COG2755	lipolytic protein G-D-S-L family
H4O14_06555	COG1183	phosphatidylcholine synthase activity
H4O14_06560	COG0688	phosphatidylethanolamine metabolic process
H4O14_06570	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H4O14_06575	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H4O14_06585	COG1534	Rna-binding protein
H4O14_06590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4O14_06595	COG1713	HD superfamily hydrolase involved in NAD metabolism
H4O14_06600	COG0799	negative regulation of ribosome biogenesis
H4O14_06605	COG2226	methyltransferase
H4O14_06610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4O14_06615	COG1596	polysaccharide export
H4O14_06615	COG1555	photosystem II stabilization
H4O14_06620	COG2131	deaminase
H4O14_06625	COG0658	competence protein
H4O14_06625	COG2333	competence protein COMEC
H4O14_06635	COG1466	dna polymerase III delta subunit
H4O14_06640	COG0268	Binds directly to 16S ribosomal RNA
H4O14_06650	COG0860	N-Acetylmuramoyl-L-alanine amidase
H4O14_06660	COG0481	GTPase activity
H4O14_06665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4O14_06675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4O14_06680	COG0443	Heat shock 70 kDa protein
H4O14_06685	COG0484	heat shock protein binding
H4O14_06690	COG2264	protein methyltransferase activity
H4O14_06695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4O14_06700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4O14_06705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H4O14_06710	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4O14_06715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4O14_06720	COG1610	YqeY-like protein
H4O14_06725	COG1030	water channel activity
H4O14_06730	COG4864	UPF0365 protein
H4O14_06750	COG1702	phosphate starvation-inducible protein PhoH
H4O14_06755	COG1480	7TM receptor with intracellular HD hydrolase
H4O14_06760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4O14_06765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4O14_06770	COG0295	cytidine deaminase activity
H4O14_06775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4O14_06785	COG1381	Involved in DNA repair and RecF pathway recombination
H4O14_06790	COG0752	glycyl-tRNA synthetase alpha subunit
H4O14_06795	COG0751	glycine-tRNA ligase activity
H4O14_06800	COG0517	IMP dehydrogenase activity
H4O14_06805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H4O14_06810	COG1671	Belongs to the UPF0178 family
H4O14_06815	COG0358	DNA primase activity
H4O14_06820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4O14_06825	COG1960	acyl-CoA dehydrogenase activity
H4O14_06830	COG2010	Cytochrome c
H4O14_06835	COG2384	SAM-dependent methyltransferase
H4O14_06840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4O14_06845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4O14_06855	COG0513	Belongs to the DEAD box helicase family
H4O14_06860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H4O14_06870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_06875	COG1121	(ABC) transporter
H4O14_06880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4O14_06885	COG0735	belongs to the Fur family
H4O14_06890	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H4O14_06895	COG4709	membrane
H4O14_06910	COG0840	transmembrane signaling receptor activity
H4O14_06915	COG5521	maltodextrose utilization protein MalA
H4O14_06920	COG1283	sodium-dependent phosphate transmembrane transporter activity
H4O14_06925	COG2839	Protein conserved in bacteria
H4O14_06935	COG0477	Major facilitator Superfamily
H4O14_06940	COG0768	penicillin binding
H4O14_06950	COG0573	inorganic phosphate transmembrane transporter activity
H4O14_06955	COG0581	inorganic phosphate transmembrane transporter activity
H4O14_06960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4O14_06965	COG0704	Plays a role in the regulation of phosphate uptake
H4O14_06970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4O14_06990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4O14_07005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4O14_07020	COG0705	Rhomboid family
H4O14_07020	COG0457	Tetratricopeptide repeat
H4O14_07025	COG4483	Protein conserved in bacteria
H4O14_07030	COG1940	carbohydrate kinase activity
H4O14_07035	COG1368	sulfuric ester hydrolase activity
H4O14_07050	COG0011	TIGRFAM Protein of
H4O14_07065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_07080	COG1393	Belongs to the ArsC family
H4O14_07090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4O14_07095	COG1459	type II secretion system
H4O14_07100	COG4537	Required for transformation and DNA binding
H4O14_07105	COG4970	Tfp pilus assembly protein FimT
H4O14_07110	COG4940	Competence protein ComGF
H4O14_07120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4O14_07165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4O14_07170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H4O14_07175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4O14_07180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4O14_07185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4O14_07190	COG0095	Lipoate-protein ligase
H4O14_07200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O14_07205	COG1321	iron dependent repressor
H4O14_07210	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4O14_07220	COG3872	metal-dependent enzyme
H4O14_07230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4O14_07235	COG0006	proline dipeptidase activity
H4O14_07255	COG3854	ATPases associated with a variety of cellular activities
H4O14_07295	COG0511	ligase activity, forming carbon-carbon bonds
H4O14_07300	COG0439	Biotin carboxylase
H4O14_07305	COG1302	Protein conserved in bacteria
H4O14_07310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4O14_07315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4O14_07320	COG1570	exodeoxyribonuclease VII activity
H4O14_07325	COG1722	exodeoxyribonuclease VII activity
H4O14_07330	COG0142	geranyltranstransferase activity
H4O14_07335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4O14_07340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H4O14_07345	COG1438	arginine binding
H4O14_07350	COG0497	DNA recombination
H4O14_07355	COG0750	zinc metalloprotease
H4O14_07360	COG0745	RESPONSE REGULATOR receiver
H4O14_07365	COG3093	addiction module antidote protein HigA
H4O14_07370	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_07380	COG3290	protein histidine kinase activity
H4O14_07380	COG3829	transcription factor binding
H4O14_07385	COG0280	phosphate acetyltransferase
H4O14_07395	COG3426	butyrate kinase activity
H4O14_07400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O14_07405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4O14_07410	COG0022	dehydrogenase e1 component
H4O14_07415	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O14_07420	COG1597	lipid kinase activity
H4O14_07425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_07430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_07430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4O14_07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_07455	COG0765	amino acid transport
H4O14_07460	COG1126	abc transporter atp-binding protein
H4O14_07465	COG4129	membrane
H4O14_07470	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_07480	COG0346	lactoylglutathione lyase activity
H4O14_07485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4O14_07490	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4O14_07495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4O14_07505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4O14_07510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H4O14_07520	COG3655	Transcriptional regulator
H4O14_07525	COG3739	integral membrane protein
H4O14_07535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4O14_07540	COG1234	tRNA 3'-trailer cleavage
H4O14_07560	COG1902	pentaerythritol trinitrate reductase activity
H4O14_07565	COG4187	Peptidase family M20/M25/M40
H4O14_07580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4O14_07585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4O14_07590	COG0300	oxidoreductase activity
H4O14_07600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4O14_07625	COG1073	alpha beta
H4O14_07635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4O14_07640	COG0183	Belongs to the thiolase family
H4O14_07645	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4O14_07650	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4O14_07675	COG0667	Aldo Keto reductase
H4O14_07685	COG0494	nUDIX hydrolase
H4O14_07690	COG1379	DNA repair
H4O14_07705	COG1300	Membrane
H4O14_07710	COG0735	belongs to the Fur family
H4O14_07720	COG4974	Belongs to the 'phage' integrase family
H4O14_07725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H4O14_07740	COG1686	Belongs to the peptidase S11 family
H4O14_07745	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_07775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4O14_07790	COG0697	spore germination
H4O14_07795	COG0019	diaminopimelate decarboxylase activity
H4O14_07800	COG4086	secreted protein
H4O14_07805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4O14_07815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4O14_07815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4O14_07820	COG0307	riboflavin synthase, alpha
H4O14_07825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4O14_07825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4O14_07830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4O14_07840	COG1547	Domain of unknown function (DUF309)
H4O14_07855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4O14_07870	COG1686	Belongs to the peptidase S11 family
H4O14_07875	COG2715	membrane protein required for spore maturation
H4O14_07880	COG0700	Nucleoside recognition
H4O14_07885	COG1187	pseudouridine synthase activity
H4O14_07890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_07895	COG1333	cytochrome c biogenesis protein
H4O14_07900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4O14_07905	COG0745	RESPONSE REGULATOR receiver
H4O14_07910	COG5002	protein histidine kinase activity
H4O14_07925	COG2096	Adenosyltransferase
H4O14_07930	COG1595	DNA-templated transcription, initiation
H4O14_07940	COG3942	CHAP domain
H4O14_07940	COG1388	LysM domain
H4O14_07945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H4O14_07950	COG5002	protein histidine kinase activity
H4O14_07955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4O14_07960	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H4O14_07965	COG1141	Ferredoxin
H4O14_07970	COG4955	Helix-turn-helix domain
H4O14_07975	COG0514	ATP-dependent DNA helicase (RecQ)
H4O14_07980	COG1266	CAAX protease self-immunity
H4O14_08005	COG0789	Transcriptional regulator
H4O14_08010	COG4862	establishment of competence for transformation
H4O14_08015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4O14_08020	COG0492	ferredoxin-NADP+ reductase activity
H4O14_08025	COG0252	asparaginase activity
H4O14_08030	COG2339	peptidase activity
H4O14_08035	COG3409	Peptidoglycan-binding domain 1 protein
H4O14_08035	COG3773	Cell wall hydrolase
H4O14_08040	COG2959	enzyme of heme biosynthesis
H4O14_08055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4O14_08065	COG0539	negative regulation of cytoplasmic translation
H4O14_08070	COG1304	FMN binding
H4O14_08095	COG1160	GTP binding
H4O14_08115	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H4O14_08120	COG0776	regulation of translation
H4O14_08135	COG0142	geranyltranstransferase activity
H4O14_08140	COG2226	methyltransferase
H4O14_08145	COG0142	geranyltranstransferase activity
H4O14_08150	COG0105	UTP biosynthetic process
H4O14_08155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4O14_08160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4O14_08165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H4O14_08170	COG4401	Chorismate mutase type I
H4O14_08180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4O14_08185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4O14_08190	COG0134	indole-3-glycerol-phosphate synthase activity
H4O14_08195	COG0135	phosphoribosylanthranilate isomerase activity
H4O14_08200	COG0133	tryptophan synthase activity
H4O14_08205	COG0159	tryptophan synthase activity
H4O14_08210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4O14_08215	COG0287	Prephenate dehydrogenase
H4O14_08230	COG0457	Tetratricopeptide repeat
H4O14_08235	COG5582	Belongs to the UPF0302 family
H4O14_08240	COG1523	belongs to the glycosyl hydrolase 13 family
H4O14_08250	COG0723	plastoquinol--plastocyanin reductase activity
H4O14_08255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4O14_08260	COG2010	Cytochrome c
H4O14_08260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4O14_08265	COG4347	Protein of unknown function (DUF1405)
H4O14_08275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_08280	COG1694	Mazg nucleotide pyrophosphohydrolase
H4O14_08285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4O14_08290	COG1803	Methylglyoxal synthase
H4O14_08295	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4O14_08300	COG0438	transferase activity, transferring glycosyl groups
H4O14_08305	COG0617	tRNA 3'-terminal CCA addition
H4O14_08315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H4O14_08320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H4O14_08325	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4O14_08330	COG1199	ATP-dependent helicase activity
H4O14_08330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4O14_08345	COG0436	Aminotransferase
H4O14_08350	COG0017	Asparaginyl-tRNA synthetase
H4O14_08355	COG3935	DnaD domain protein
H4O14_08360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4O14_08375	COG4499	WXG100 protein secretion system (Wss), protein YukC
H4O14_08375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_08380	COG3331	DNA recombination
H4O14_08440	COG2190	(PTS) system
H4O14_08445	COG1111	helicase
H4O14_08445	COG1205	dead DEAH box helicase
H4O14_08450	COG3359	exonuclease
H4O14_08460	COG4474	Belongs to the UPF0398 family
H4O14_08475	COG0116	Belongs to the methyltransferase superfamily
H4O14_08485	COG1199	ATP-dependent helicase activity
H4O14_08490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H4O14_08505	COG2233	PERMEase
H4O14_08515	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_08525	COG1247	-acetyltransferase
H4O14_08530	COG3424	synthase
H4O14_08535	COG1755	Isoprenylcysteine carboxyl methyltransferase
H4O14_08550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4O14_08560	COG0490	domain, Protein
H4O14_08565	COG0475	glutathione-regulated potassium exporter activity
H4O14_08575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H4O14_08595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H4O14_08600	COG0702	epimerase
H4O14_08615	COG0328	RNA-DNA hybrid ribonuclease activity
H4O14_08640	COG1278	Cold shock
H4O14_08670	COG2226	methyltransferase
H4O14_08685	COG1988	membrane-bound metal-dependent
H4O14_08690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4O14_08695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H4O14_08715	COG0386	Belongs to the glutathione peroxidase family
H4O14_08725	COG1307	EDD domain protein, DegV family
H4O14_08730	COG1418	mRNA catabolic process
H4O14_08735	COG1413	lyase activity
H4O14_08745	COG0024	Methionine aminopeptidase
H4O14_08750	COG0129	dihydroxy-acid dehydratase activity
H4O14_08760	COG2136	Putative SAM-dependent methyltransferase
H4O14_08760	COG2521	methyltransferase
H4O14_08775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4O14_08780	COG0861	Integral membrane protein TerC family
H4O14_08800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4O14_08805	COG1272	protein, Hemolysin III
H4O14_08810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H4O14_08815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4O14_08825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4O14_08855	COG1999	signal sequence binding
H4O14_08860	COG2140	Oxalate decarboxylase
H4O14_08870	COG4698	Protein conserved in bacteria
H4O14_08880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4O14_08910	COG1846	Transcriptional regulator
H4O14_08915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4O14_08915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4O14_08925	COG0346	lactoylglutathione lyase activity
H4O14_08930	COG0456	acetyltransferase
H4O14_08940	COG1278	Cold shock
H4O14_08970	COG2267	carboxylic ester hydrolase activity
H4O14_08985	COG1078	dGTPase activity
H4O14_08990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_09000	COG0778	Nitroreductase
H4O14_09005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4O14_09035	COG0456	acetyltransferase
H4O14_09045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4O14_09050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4O14_09060	COG0697	spore germination
H4O14_09070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4O14_09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_09110	COG1609	Transcriptional regulator
H4O14_09120	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H4O14_09135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H4O14_09145	COG2186	Transcriptional regulator
H4O14_09150	COG0277	FAD linked oxidase domain protein
H4O14_09155	COG0385	Bile acid
H4O14_09160	COG0372	Belongs to the citrate synthase family
H4O14_09165	COG0583	DNA-binding transcription factor activity
H4O14_09175	COG1113	amino acid transport
H4O14_09185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4O14_09215	COG2364	Membrane
H4O14_09220	COG1846	Transcriptional regulator
H4O14_09225	COG0456	acetyltransferase
H4O14_09245	COG0346	lactoylglutathione lyase activity
H4O14_09250	COG0640	Transcriptional regulator
H4O14_09280	COG1834	amidinotransferase
H4O14_09290	COG3403	YqcI/YcgG family
H4O14_09295	COG1280	lysine exporter protein (LysE YggA)
H4O14_09300	COG1113	amino acid transport
H4O14_09310	COG2814	Major facilitator Superfamily
H4O14_09340	COG1404	Belongs to the peptidase S8 family
H4O14_09390	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H4O14_09405	COG2814	Major facilitator Superfamily
H4O14_09410	COG1309	transcriptional regulator
H4O14_09415	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_09420	COG1609	Transcriptional regulator
H4O14_09430	COG0673	inositol 2-dehydrogenase activity
H4O14_09435	COG0673	inositol 2-dehydrogenase activity
H4O14_09440	COG1082	Xylose isomerase domain protein TIM barrel
H4O14_09445	COG2814	Major facilitator Superfamily
H4O14_09460	COG0861	Integral membrane protein TerC family
H4O14_09480	COG3383	formate dehydrogenase (NAD+) activity
H4O14_09485	COG2427	Protein of unknown function (DUF1641)
H4O14_09495	COG0489	protein tyrosine kinase activity
H4O14_09500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4O14_09515	COG0746	molybdenum cofactor guanylyltransferase activity
H4O14_09520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4O14_09525	COG0303	'Molybdopterin
H4O14_09530	COG1763	Mo-molybdopterin cofactor biosynthetic process
H4O14_09535	COG0314	molybdopterin synthase activity
H4O14_09540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4O14_09545	COG3383	formate dehydrogenase (NAD+) activity
H4O14_09555	COG2427	Protein of unknown function (DUF1641)
H4O14_09565	COG5609	conserved protein (DUF2294)
H4O14_09575	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4O14_09595	COG1263	PTS System
H4O14_09595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_09600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O14_09605	COG0346	lactoylglutathione lyase activity
H4O14_09615	COG1309	transcriptional regulator
H4O14_09620	COG4221	oxidoreductase activity
H4O14_09625	COG2723	6-phospho-beta-galactosidase activity
H4O14_09630	COG2188	Transcriptional regulator
H4O14_09640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H4O14_09645	COG1959	2 iron, 2 sulfur cluster binding
H4O14_09650	COG0702	epimerase
H4O14_09655	COG1132	(ABC) transporter
H4O14_09660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4O14_09665	COG0697	spore germination
H4O14_09680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4O14_09685	COG0492	ferredoxin-NADP+ reductase activity
H4O14_09720	COG5566	PFAM Mor transcription activator
H4O14_09745	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H4O14_09760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4O14_09765	COG1595	DNA-templated transcription, initiation
H4O14_09785	COG1785	Belongs to the alkaline phosphatase family
H4O14_09795	COG1114	Component of the transport system for branched-chain amino acids
H4O14_09800	COG1125	glycine betaine transport
H4O14_09800	COG0517	IMP dehydrogenase activity
H4O14_09805	COG1174	glycine betaine transport
H4O14_09810	COG1732	Glycine betaine
H4O14_09815	COG1174	glycine betaine transport
H4O14_09825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4O14_09835	COG0598	Magnesium transport protein CorA
H4O14_09865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4O14_09870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4O14_09875	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4O14_09900	COG2814	Major facilitator Superfamily
H4O14_09910	COG3708	Transcriptional regulator
H4O14_09910	COG2207	Transcriptional regulator
H4O14_09915	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_09925	COG1454	alcohol dehydrogenase
H4O14_09935	COG2318	DinB family
H4O14_09965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4O14_09985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_10030	COG0697	spore germination
H4O14_10045	COG5634	Uncharacterized conserved protein (DUF2278)
H4O14_10050	COG1609	Transcriptional regulator
H4O14_10055	COG1653	transport
H4O14_10060	COG4209	transmembrane transport
H4O14_10065	COG0395	ABC-type sugar transport system, permease component
H4O14_10080	COG3842	ATPase activity
H4O14_10085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_10090	COG0765	amino acid transport
H4O14_10125	COG0596	Alpha beta hydrolase
H4O14_10130	COG0431	NADPH-dependent FMN reductase
H4O14_10135	COG5583	Uncharacterized small protein (DUF2292)
H4O14_10140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_10150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4O14_10155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_10160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_10165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_10185	COG0076	glutamate decarboxylase activity
H4O14_10190	COG3878	Protein conserved in bacteria
H4O14_10195	COG2610	gluconate transmembrane transporter activity
H4O14_10200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4O14_10205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4O14_10210	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_10215	COG3290	protein histidine kinase activity
H4O14_10215	COG3829	transcription factor binding
H4O14_10225	COG2207	Transcriptional regulator
H4O14_10240	COG0640	Transcriptional regulator
H4O14_10260	COG1393	Belongs to the ArsC family
H4O14_10265	COG2357	RelA SpoT domain protein
H4O14_10280	COG0737	Belongs to the 5'-nucleotidase family
H4O14_10280	COG1525	nuclease
H4O14_10280	COG4085	toxin activity
H4O14_10315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O14_10320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4O14_10325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4O14_10330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4O14_10335	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_10340	COG0456	acetyltransferase
H4O14_10345	COG3829	transcription factor binding
H4O14_10350	COG1509	lysine 2,3-aminomutase activity
H4O14_10370	COG3647	Membrane
H4O14_10380	COG0671	phosphoesterase, PA-phosphatase related
H4O14_10405	COG1846	Transcriptional regulator
H4O14_10410	COG0477	Major facilitator Superfamily
H4O14_10415	COG2318	DinB family
H4O14_10425	COG2814	Major facilitator Superfamily
H4O14_10435	COG1349	DNA-binding transcription factor activity
H4O14_10440	COG0673	inositol 2-dehydrogenase activity
H4O14_10460	COG1279	arginine transmembrane transporter activity
H4O14_10465	COG2031	fatty acid transporter
H4O14_10470	COG0583	DNA-binding transcription factor activity
H4O14_10475	COG3180	Ammonia monooxygenase
H4O14_10510	COG3858	chitin binding
H4O14_10565	COG0346	lactoylglutathione lyase activity
H4O14_10575	COG2814	Major facilitator Superfamily
H4O14_10580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_10605	COG1131	(ABC) transporter
H4O14_10620	COG5522	Integral membrane protein (intg_mem_TP0381)
H4O14_10655	COG0515	serine threonine protein kinase
H4O14_10655	COG2815	serine threonine protein kinase
H4O14_10660	COG4326	sporulation control protein
H4O14_10685	COG0697	spore germination
H4O14_10695	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_10705	COG0671	phosphoesterase, PA-phosphatase related
H4O14_10725	COG1876	peptidase activity
H4O14_10740	COG2226	methyltransferase
H4O14_10745	COG0793	Belongs to the peptidase S41A family
H4O14_10745	COG3409	Peptidoglycan-binding domain 1 protein
H4O14_10750	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4O14_10755	COG0400	carboxylic ester hydrolase activity
H4O14_10760	COG0778	Nitroreductase
H4O14_10765	COG1733	regulation of RNA biosynthetic process
H4O14_10770	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_10785	COG4876	unkown
H4O14_10800	COG2962	Rard protein
H4O14_10810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4O14_10815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H4O14_10820	COG0534	Mate efflux family protein
H4O14_10825	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H4O14_10830	COG2252	PERMEase
H4O14_10845	COG0791	NLP P60 protein
H4O14_10845	COG1388	LysM domain
H4O14_10850	COG1309	transcriptional regulator
H4O14_10860	COG0018	arginyl-trna synthetase
H4O14_10865	COG2032	superoxide dismutase activity
H4O14_10870	COG1368	sulfuric ester hydrolase activity
H4O14_10875	COG2720	vancomycin resistance protein
H4O14_10880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_10885	COG0300	oxidoreductase activity
H4O14_10900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4O14_10905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_10910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_10930	COG0697	spore germination
H4O14_10935	COG0714	Associated with various cellular activities
H4O14_10940	COG4548	von Willebrand factor, type A
H4O14_10955	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O14_10960	COG2031	fatty acid transporter
H4O14_10965	COG1902	pentaerythritol trinitrate reductase activity
H4O14_10975	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_10985	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_10995	COG1657	PFAM Prenyltransferase squalene oxidase
H4O14_11005	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_11030	COG4975	Glucose uptake
H4O14_11035	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_11060	COG3842	ATPase activity
H4O14_11070	COG0561	phosphatase activity
H4O14_11080	COG0577	efflux transmembrane transporter activity
H4O14_11085	COG1136	(ABC) transporter
H4O14_11090	COG0745	RESPONSE REGULATOR receiver
H4O14_11095	COG5002	protein histidine kinase activity
H4O14_11115	COG4209	transmembrane transport
H4O14_11120	COG0395	ABC-type sugar transport system, permease component
H4O14_11125	COG1653	transport
H4O14_11130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H4O14_11135	COG5578	integral membrane protein
H4O14_11150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4O14_11165	COG4191	Histidine kinase
H4O14_11180	COG0514	ATP-dependent DNA helicase (RecQ)
H4O14_11185	COG1164	Oligoendopeptidase f
H4O14_11195	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_11200	COG2329	Antibiotic biosynthesis monooxygenase
H4O14_11210	COG2318	DinB family
H4O14_11235	COG0733	neurotransmitter:sodium symporter activity
H4O14_11240	COG1280	lysine exporter protein (LysE YggA)
H4O14_11255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H4O14_11260	COG0351	phosphomethylpyrimidine kinase
H4O14_11270	COG1785	Belongs to the alkaline phosphatase family
H4O14_11280	COG0657	acetylesterase activity
H4O14_11290	COG0076	glutamate decarboxylase activity
H4O14_11315	COG1349	DNA-binding transcription factor activity
H4O14_11320	COG0561	phosphatase activity
H4O14_11325	COG2205	protein histidine kinase activity
H4O14_11335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H4O14_11345	COG3104	oligopeptide transport
H4O14_11350	COG1309	transcriptional regulator
H4O14_11355	COG3584	3D domain protein
H4O14_11355	COG3583	domain protein
H4O14_11360	COG2223	nitrite transmembrane transporter activity
H4O14_11365	COG0527	aspartate kinase activity
H4O14_11370	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_11380	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_11400	COG1960	acyl-CoA dehydrogenase activity
H4O14_11420	COG3944	biosynthesis protein
H4O14_11425	COG0489	protein tyrosine kinase activity
H4O14_11440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4O14_11445	COG0438	transferase activity, transferring glycosyl groups
H4O14_11450	COG1216	Glycosyl transferase, family 2
H4O14_11455	COG0438	transferase activity, transferring glycosyl groups
H4O14_11460	COG0463	Glycosyl transferase, family 2
H4O14_11485	COG1216	Glycosyl transferase, family 2
H4O14_11485	COG1442	glycosyl transferase family 8
H4O14_11505	COG0110	maltose O-acetyltransferase activity
H4O14_11515	COG0463	Glycosyl transferase, family 2
H4O14_11515	COG1216	Glycosyl transferase, family 2
H4O14_11520	COG1442	glycosyl transferase family 8
H4O14_11525	COG1216	Glycosyl transferase, family 2
H4O14_11535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O14_11540	COG0110	maltose O-acetyltransferase activity
H4O14_11545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4O14_11550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4O14_11585	COG1132	(ABC) transporter
H4O14_11600	COG1132	(ABC) transporter
H4O14_11635	COG3340	Belongs to the peptidase S51 family
H4O14_11680	COG4191	Histidine kinase
H4O14_11690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O14_11690	COG3153	acetyltransferase
H4O14_11695	COG0456	acetyltransferase
H4O14_11705	COG3773	Cell wall hydrolase
H4O14_11710	COG2391	methyltransferase activity
H4O14_11730	COG0667	Aldo Keto reductase
H4O14_11735	COG0673	inositol 2-dehydrogenase activity
H4O14_11745	COG1653	transport
H4O14_11750	COG1175	transmembrane transport
H4O14_11755	COG0395	ABC-type sugar transport system, permease component
H4O14_11760	COG0673	inositol 2-dehydrogenase activity
H4O14_11770	COG0673	inositol 2-dehydrogenase activity
H4O14_11775	COG0024	Methionine aminopeptidase
H4O14_11780	COG2132	Multicopper oxidase
H4O14_11795	COG2186	Transcriptional regulator
H4O14_11800	COG0277	FAD linked oxidase domain protein
H4O14_11805	COG0247	lactate metabolic process
H4O14_11810	COG0277	FAD linked oxidase domain protein
H4O14_11815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4O14_11820	COG0281	malic enzyme
H4O14_11825	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4O14_11830	COG1414	Transcriptional regulator
H4O14_11835	COG1620	l-lactate permease
H4O14_11840	COG2169	Transcriptional regulator
H4O14_11845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4O14_11865	COG0693	protein deglycase activity
H4O14_11870	COG3835	regulator
H4O14_11875	COG0277	FAD linked oxidase domain protein
H4O14_11880	COG0247	lactate metabolic process
H4O14_11885	COG0247	lactate metabolic process
H4O14_11890	COG1139	Iron-sulfur cluster binding protein
H4O14_11895	COG1556	Lactate utilization protein
H4O14_11900	COG1914	H( )-stimulated, divalent metal cation uptake system
H4O14_11905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H4O14_11910	COG1984	allophanate hydrolase subunit 2
H4O14_11915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4O14_11920	COG1193	negative regulation of DNA recombination
H4O14_11940	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4O14_11945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4O14_11955	COG0303	'Molybdopterin
H4O14_11960	COG1763	Mo-molybdopterin cofactor biosynthetic process
H4O14_11965	COG0314	molybdopterin synthase activity
H4O14_11970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H4O14_11975	COG3383	formate dehydrogenase (NAD+) activity
H4O14_11980	COG2427	Protein of unknown function (DUF1641)
H4O14_11985	COG2223	nitrite transmembrane transporter activity
H4O14_12000	COG4221	oxidoreductase activity
H4O14_12005	COG0789	Transcriptional regulator
H4O14_12010	COG0656	L-ascorbic acid biosynthetic process
H4O14_12015	COG0110	maltose O-acetyltransferase activity
H4O14_12030	COG0640	Transcriptional regulator
H4O14_12050	COG0463	Glycosyl transferase, family 2
H4O14_12085	COG0442	prolyl-tRNA aminoacylation
H4O14_12115	COG5553	Cysteine dioxygenase type I
H4O14_12125	COG0322	excinuclease ABC activity
H4O14_12135	COG1349	DNA-binding transcription factor activity
H4O14_12140	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_12145	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H4O14_12155	COG3906	Belongs to the UPF0473 family
H4O14_12165	COG4589	Belongs to the CDS family
H4O14_12175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_12185	COG2801	Transposase and inactivated derivatives
H4O14_12220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H4O14_12225	COG1492	cobalamin metabolic process
H4O14_12230	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4O14_12235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4O14_12240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4O14_12245	COG1120	ATPase activity
H4O14_12250	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4O14_12255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4O14_12265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H4O14_12270	COG0588	phosphoglycerate mutase activity
H4O14_12285	COG0640	Transcriptional regulator
H4O14_12305	COG2076	Multidrug Resistance protein
H4O14_12310	COG2076	Multidrug Resistance protein
H4O14_12325	COG0667	Aldo Keto reductase
H4O14_12330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O14_12345	COG0747	negative chemotaxis
H4O14_12350	COG0601	transmembrane transport
H4O14_12355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_12360	COG0444	Belongs to the ABC transporter superfamily
H4O14_12365	COG1124	(ABC) transporter
H4O14_12380	COG0523	cobalamin synthesis protein
H4O14_12395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_12400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4O14_12405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4O14_12405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4O14_12410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4O14_12415	COG0698	ribose 5-phosphate isomerase
H4O14_12420	COG1609	Transcriptional regulator
H4O14_12425	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_12440	COG1115	amino acid carrier protein
H4O14_12450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4O14_12455	COG0187	DNA topoisomerase II activity
H4O14_12460	COG1832	CoA-binding protein
H4O14_12465	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H4O14_12470	COG2843	Capsule synthesis protein
H4O14_12475	COG4841	protein insertion into membrane
H4O14_12485	COG0824	Thioesterase
H4O14_12505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_12510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4O14_12530	COG0071	Belongs to the small heat shock protein (HSP20) family
H4O14_12555	COG4846	Membrane protein involved in cytochrome C biogenesis
H4O14_12560	COG2201	protein-glutamate methylesterase activity
H4O14_12565	COG0785	Cytochrome C biogenesis protein
H4O14_12580	COG3763	UPF0154 protein
H4O14_12595	COG4224	UPF0291 protein
H4O14_12600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H4O14_12605	COG1388	LysM domain
H4O14_12610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4O14_12620	COG1620	l-lactate permease
H4O14_12625	COG0039	L-malate dehydrogenase activity
H4O14_12645	COG0174	glutamine synthetase
H4O14_12650	COG0789	Transcriptional regulator
H4O14_12655	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H4O14_12660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4O14_12665	COG2860	membrane
H4O14_12670	COG0464	growth
H4O14_12680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4O14_12690	COG1994	Peptidase M50
H4O14_12700	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4O14_12705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4O14_12710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H4O14_12720	COG4550	Control of competence regulator ComK, YlbF/YmcA
H4O14_12725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4O14_12730	COG0156	8-amino-7-oxononanoate synthase activity
H4O14_12735	COG1063	alcohol dehydrogenase
H4O14_12740	COG1013	pyruvate-flavodoxin oxidoreductase activity
H4O14_12745	COG0674	pyruvate-flavodoxin oxidoreductase activity
H4O14_12745	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H4O14_12755	COG2359	stage V sporulation protein S
H4O14_12760	COG1692	metallophosphoesterase
H4O14_12765	COG1418	mRNA catabolic process
H4O14_12770	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4O14_12775	COG1058	Belongs to the CinA family
H4O14_12775	COG1546	Belongs to the CinA family
H4O14_12780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4O14_12785	COG1426	Protein conserved in bacteria
H4O14_12805	COG0300	oxidoreductase activity
H4O14_12810	COG0612	Peptidase, M16
H4O14_12815	COG0612	Peptidase, M16
H4O14_12825	COG1079	Belongs to the binding-protein-dependent transport system permease family
H4O14_12830	COG4603	Belongs to the binding-protein-dependent transport system permease family
H4O14_12835	COG3845	ABC transporter
H4O14_12840	COG1744	ABC transporter substrate-binding protein PnrA-like
H4O14_12845	COG2188	Transcriptional regulator
H4O14_12850	COG4980	gas vesicle protein
H4O14_12850	COG1674	ftsk spoiiie
H4O14_12860	COG0740	serine-type endopeptidase activity
H4O14_12865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4O14_12880	COG0527	aspartate kinase activity
H4O14_12885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4O14_12890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4O14_12895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4O14_12900	COG1873	PFAM PRC-barrel domain
H4O14_12905	COG0612	Peptidase, M16
H4O14_12910	COG0726	polysaccharide deacetylase
H4O14_12915	COG1185	polyribonucleotide nucleotidyltransferase activity
H4O14_12925	COG0196	riboflavin kinase activity
H4O14_12930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4O14_12935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4O14_12940	COG1550	Protein conserved in bacteria
H4O14_12950	COG1358	cellular component organization or biogenesis
H4O14_12955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H4O14_12965	COG0779	Required for maturation of 30S ribosomal subunits
H4O14_12970	COG2176	DNA-directed DNA polymerase activity
H4O14_12975	COG0442	prolyl-tRNA aminoacylation
H4O14_12980	COG0750	zinc metalloprotease
H4O14_12985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4O14_12990	COG4589	Belongs to the CDS family
H4O14_12995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4O14_13000	COG0233	cytoplasmic translational termination
H4O14_13005	COG0528	UMP kinase activity
H4O14_13015	COG0052	Belongs to the universal ribosomal protein uS2 family
H4O14_13025	COG1191	sigma factor activity
H4O14_13030	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H4O14_13035	COG1776	CheC inhibitor of MCP methylation
H4O14_13040	COG0835	chemotaxis
H4O14_13045	COG0643	Histidine kinase
H4O14_13045	COG2198	Histidine kinase
H4O14_13050	COG2201	protein-glutamate methylesterase activity
H4O14_13055	COG0455	bacterial-type flagellum organization
H4O14_13060	COG1419	protein localization to endoplasmic reticulum
H4O14_13065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4O14_13070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4O14_13075	COG1684	flagellar biosynthetic protein fliR
H4O14_13080	COG1987	bacterial-type flagellum assembly
H4O14_13085	COG1338	Plays a role in the flagellum-specific transport system
H4O14_13090	COG3190	flagellar
H4O14_13095	COG2201	protein-glutamate methylesterase activity
H4O14_13100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4O14_13100	COG1776	CheC inhibitor of MCP methylation
H4O14_13105	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4O14_13110	COG1580	Controls the rotational direction of flagella during chemotaxis
H4O14_13115	COG1582	Flagellar protein (FlbD)
H4O14_13120	COG4786	Flagellar basal body rod
H4O14_13130	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H4O14_13135	COG3144	bacterial-type flagellum assembly
H4O14_13145	COG2882	bacterial-type flagellum organization
H4O14_13150	COG1157	protein secretion by the type III secretion system
H4O14_13155	COG1317	bacterial-type flagellum organization
H4O14_13160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4O14_13165	COG1766	The M ring may be actively involved in energy transduction
H4O14_13170	COG1677	Flagellar hook-basal body complex protein FliE
H4O14_13175	COG1558	bacterial-type flagellum-dependent cell motility
H4O14_13180	COG1815	bacterial-type flagellum-dependent cell motility
H4O14_13185	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H4O14_13190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H4O14_13200	COG4974	Belongs to the 'phage' integrase family
H4O14_13205	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H4O14_13210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4O14_13215	COG0758	DNA mediated transformation
H4O14_13220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4O14_13225	COG0045	succinate-CoA ligase (ADP-forming) activity
H4O14_13230	COG2257	FlhB HrpN YscU SpaS Family
H4O14_13255	COG0335	large ribosomal subunit rRNA binding
H4O14_13260	COG0336	Belongs to the RNA methyltransferase TrmD family
H4O14_13265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4O14_13275	COG1837	Belongs to the UPF0109 family
H4O14_13285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4O14_13295	COG0552	protein localization to endoplasmic reticulum
H4O14_13300	COG1196	nuclear chromosome segregation
H4O14_13310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4O14_13315	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_13320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4O14_13325	COG0416	fatty acid biosynthetic process
H4O14_13330	COG1349	DNA-binding transcription factor activity
H4O14_13335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4O14_13340	COG1760	l-serine dehydratase
H4O14_13345	COG1760	l-serine dehydratase
H4O14_13350	COG1461	Dihydroxyacetone kinase
H4O14_13355	COG1302	Protein conserved in bacteria
H4O14_13370	COG1564	THIamine pyrophosphokinase
H4O14_13375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4O14_13380	COG1162	GTPase activity
H4O14_13385	COG0515	serine threonine protein kinase
H4O14_13385	COG2815	serine threonine protein kinase
H4O14_13390	COG0631	protein serine/threonine phosphatase activity
H4O14_13400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4O14_13400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4O14_13415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4O14_13420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4O14_13425	COG1758	RNA polymerase activity
H4O14_13430	COG0194	GDP metabolic process
H4O14_13440	COG1561	YicC-like family, N-terminal region
H4O14_13445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4O14_13470	COG0529	Catalyzes the synthesis of activated sulfate
H4O14_13480	COG0306	phosphate transporter
H4O14_13505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H4O14_13510	COG0284	orotidine-5'-phosphate decarboxylase activity
H4O14_13515	COG0167	dihydroorotate dehydrogenase activity
H4O14_13520	COG0543	2 iron, 2 sulfur cluster binding
H4O14_13525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4O14_13530	COG0505	Belongs to the CarA family
H4O14_13535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4O14_13550	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H4O14_13555	COG0564	pseudouridine synthase activity
H4O14_13565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4O14_13570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H4O14_13575	COG3599	regulation of cell shape
H4O14_13580	COG2302	S4 RNA-binding domain
H4O14_13585	COG0762	integral membrane protein
H4O14_13590	COG1799	cell septum assembly
H4O14_13595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4O14_13600	COG1496	oxidoreductase activity
H4O14_13605	COG1873	PFAM PRC-barrel domain
H4O14_13610	COG0701	Predicted permease
H4O14_13615	COG3689	TIGRFAM TIGR03943 family protein
H4O14_13620	COG1191	sigma factor activity
H4O14_13625	COG1191	sigma factor activity
H4O14_13635	COG4412	M6 family metalloprotease domain protein
H4O14_13635	COG1404	Belongs to the peptidase S8 family
H4O14_13640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4O14_13645	COG0849	cell division
H4O14_13650	COG3856	small basic protein
H4O14_13655	COG3879	Bacterial protein of unknown function (DUF881)
H4O14_13660	COG3879	Bacterial protein of unknown function (DUF881)
H4O14_13665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4O14_13670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4O14_13680	COG0772	Belongs to the SEDS family
H4O14_13685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4O14_13690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4O14_13695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4O14_13700	COG0768	penicillin binding
H4O14_13705	COG0768	penicillin binding
H4O14_13710	COG4839	cell division protein FtsL
H4O14_13715	COG0275	rRNA processing
H4O14_13720	COG2001	Belongs to the MraZ family
H4O14_13725	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H4O14_13735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4O14_13740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4O14_13745	COG0511	ligase activity, forming carbon-carbon bonds
H4O14_13750	COG0439	Biotin carboxylase
H4O14_13755	COG0454	-acetyltransferase
H4O14_13765	COG1024	Enoyl-CoA hydratase
H4O14_13770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4O14_13775	COG1399	metal-binding, possibly nucleic acid-binding protein
H4O14_13780	COG1323	Belongs to the UPF0348 family
H4O14_13790	COG3480	Lon protease (S16) C-terminal proteolytic domain
H4O14_13795	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4O14_13800	COG3314	Sporulation integral membrane protein YlbJ
H4O14_13805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4O14_13810	COG0742	ribosomal rna small subunit methyltransferase
H4O14_13825	COG3679	Belongs to the UPF0342 family
H4O14_13850	COG2340	Cysteine-rich secretory protein family
H4O14_13855	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H4O14_13865	COG0628	permease
H4O14_13880	COG3336	cytochrome c oxidase
H4O14_13890	COG1845	cytochrome c oxidase, subunit III
H4O14_13895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4O14_13900	COG2010	Cytochrome c
H4O14_13900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4O14_13910	COG1612	heme a metabolic process
H4O14_13915	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H4O14_13920	COG0772	Belongs to the SEDS family
H4O14_13925	COG4838	Belongs to the UPF0358 family
H4O14_13930	COG2066	Belongs to the glutaminase family
H4O14_13935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4O14_13940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4O14_13955	COG4896	Protein conserved in bacteria
H4O14_13975	COG1217	gtp-binding protein TYPA
H4O14_13990	COG0483	inositol monophosphate 1-phosphatase activity
H4O14_14000	COG4493	Belongs to the UPF0637 family
H4O14_14005	COG4476	Belongs to the UPF0223 family
H4O14_14020	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_14030	COG0410	ABC transporter
H4O14_14055	COG1024	Enoyl-CoA hydratase
H4O14_14060	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_14065	COG2045	Belongs to the ComB family
H4O14_14080	COG1024	Enoyl-CoA hydratase
H4O14_14085	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_14095	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_14100	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_14105	COG0183	Belongs to the thiolase family
H4O14_14110	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_14115	COG1960	acyl-CoA dehydrogenase activity
H4O14_14120	COG1982	Orn Lys Arg decarboxylase major
H4O14_14150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_14155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O14_14160	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4O14_14165	COG0022	dehydrogenase e1 component
H4O14_14170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4O14_14185	COG0242	peptide deformylase activity
H4O14_14190	COG0561	phosphatase activity
H4O14_14200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4O14_14210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4O14_14220	COG0569	domain protein
H4O14_14225	COG1294	oxidase, subunit
H4O14_14230	COG1271	oxidase subunit
H4O14_14240	COG3852	Histidine kinase
H4O14_14245	COG4637	Psort location Cytoplasmic, score
H4O14_14250	COG3180	Ammonia monooxygenase
H4O14_14255	COG1607	acyl-coa hydrolase
H4O14_14260	COG1077	Cell shape determining protein MreB Mrl
H4O14_14265	COG2720	vancomycin resistance protein
H4O14_14270	COG0488	(ABC) transporter
H4O14_14280	COG1960	acyl-CoA dehydrogenase activity
H4O14_14285	COG2309	aminopeptidase activity
H4O14_14295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4O14_14300	COG0488	(ABC) transporter
H4O14_14320	COG0681	Belongs to the peptidase S26 family
H4O14_14340	COG1136	(ABC) transporter
H4O14_14345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4O14_14355	COG1132	(ABC) transporter
H4O14_14360	COG1132	(ABC) transporter
H4O14_14365	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4O14_14380	COG0110	maltose O-acetyltransferase activity
H4O14_14390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O14_14395	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_14405	COG3835	regulator
H4O14_14430	COG0493	'glutamate synthase
H4O14_14470	COG1278	Cold shock
H4O14_14475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4O14_14480	COG0450	alkyl hydroperoxide reductase
H4O14_14485	COG0668	transmembrane transport
H4O14_14495	COG1473	amidohydrolase
H4O14_14505	COG0716	FMN binding
H4O14_14515	COG0716	FMN binding
H4O14_14520	COG0583	DNA-binding transcription factor activity
H4O14_14535	COG0477	Major facilitator Superfamily
H4O14_14540	COG0517	IMP dehydrogenase activity
H4O14_14550	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H4O14_14560	COG4703	Protein of unknown function (DUF1797)
H4O14_14590	COG2200	EAL domain
H4O14_14595	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_14600	COG1408	metallophosphoesterase
H4O14_14605	COG3300	MHYT domain
H4O14_14605	COG5001	Diguanylate cyclase
H4O14_14610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4O14_14615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4O14_14630	COG1376	ErfK ybiS ycfS ynhG family protein
H4O14_14635	COG2814	Major facilitator Superfamily
H4O14_14655	COG0835	chemotaxis
H4O14_14655	COG0784	Response regulator, receiver
H4O14_14675	COG5002	protein histidine kinase activity
H4O14_14700	COG0598	Magnesium transport protein CorA
H4O14_14705	COG0436	Aminotransferase
H4O14_14710	COG4191	Histidine kinase
H4O14_14730	COG0768	penicillin binding
H4O14_14735	COG2340	Cysteine-rich secretory protein family
H4O14_14740	COG0456	acetyltransferase
H4O14_14745	COG2084	Dehydrogenase
H4O14_14760	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_14765	COG1533	DNA photolyase activity
H4O14_14775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4O14_14780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4O14_14785	COG2190	(PTS) system
H4O14_14785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_14785	COG1263	PTS System
H4O14_14790	COG3711	transcriptional antiterminator
H4O14_14805	COG0561	phosphatase activity
H4O14_14810	COG5001	Diguanylate cyclase
H4O14_14810	COG3300	MHYT domain
H4O14_14825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4O14_14850	COG1525	nuclease
H4O14_14855	COG0006	proline dipeptidase activity
H4O14_14875	COG2217	Heavy metal translocating P-type atpase
H4O14_14885	COG3209	COG3209 Rhs family protein
H4O14_14895	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4O14_14900	COG2244	polysaccharide biosynthetic process
H4O14_14920	COG3773	Cell wall hydrolase
H4O14_14930	COG5002	protein histidine kinase activity
H4O14_14950	COG0702	epimerase
H4O14_14960	COG4873	Protein conserved in bacteria
H4O14_14965	COG0456	acetyltransferase
H4O14_14970	COG1388	LysM domain
H4O14_14970	COG3584	3D domain protein
H4O14_14980	COG2135	peptidase activity
H4O14_15000	COG1278	Cold shock
H4O14_15005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4O14_15015	COG0720	synthase
H4O14_15020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4O14_15040	COG1253	flavin adenine dinucleotide binding
H4O14_15050	COG3949	Membrane
H4O14_15055	COG0542	response to heat
H4O14_15070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H4O14_15075	COG1360	Flagellar Motor Protein
H4O14_15080	COG1846	Transcriptional regulator
H4O14_15085	COG0737	Belongs to the 5'-nucleotidase family
H4O14_15090	COG3852	Histidine kinase
H4O14_15095	COG0667	Aldo Keto reductase
H4O14_15110	COG0753	catalase activity
H4O14_15135	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H4O14_15140	COG0235	Class ii aldolase
H4O14_15145	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H4O14_15150	COG1850	ribulose-bisphosphate carboxylase activity
H4O14_15155	COG0436	Aminotransferase
H4O14_15160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O14_15165	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H4O14_15170	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H4O14_15190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4O14_15195	COG5002	protein histidine kinase activity
H4O14_15200	COG3594	Acyltransferase
H4O14_15240	COG0412	Dienelactone hydrolase
H4O14_15270	COG1388	LysM domain
H4O14_15290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4O14_15295	COG0598	Magnesium transport protein CorA
H4O14_15300	COG1113	amino acid transport
H4O14_15305	COG0598	Magnesium transport protein CorA
H4O14_15315	COG1525	nuclease
H4O14_15315	COG4085	toxin activity
H4O14_15315	COG0737	Belongs to the 5'-nucleotidase family
H4O14_15325	COG0768	penicillin binding
H4O14_15330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4O14_15335	COG0501	Belongs to the peptidase M48B family
H4O14_15355	COG1191	sigma factor activity
H4O14_15360	COG0861	Integral membrane protein TerC family
H4O14_15365	COG0586	Pfam SNARE associated Golgi protein
H4O14_15380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H4O14_15385	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4O14_15390	COG3285	dna ligase
H4O14_15390	COG1793	dna ligase
H4O14_15395	COG1846	Transcriptional regulator
H4O14_15405	COG0746	molybdenum cofactor guanylyltransferase activity
H4O14_15410	COG3541	Predicted nucleotidyltransferase
H4O14_15430	COG0789	Transcriptional regulator
H4O14_15435	COG0840	transmembrane signaling receptor activity
H4O14_15440	COG1764	response to oxidative stress
H4O14_15445	COG1846	Transcriptional regulator
H4O14_15460	COG1609	Transcriptional regulator
H4O14_15470	COG1082	Xylose isomerase domain protein TIM barrel
H4O14_15475	COG0673	inositol 2-dehydrogenase activity
H4O14_15480	COG0673	inositol 2-dehydrogenase activity
H4O14_15485	COG1595	DNA-templated transcription, initiation
H4O14_15505	COG2602	Beta-lactamase
H4O14_15530	COG2404	hydrolase activity, acting on ester bonds
H4O14_15540	COG2323	membrane
H4O14_15545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O14_15570	COG0642	Histidine kinase
H4O14_15575	COG0745	RESPONSE REGULATOR receiver
H4O14_15580	COG1929	Belongs to the glycerate kinase type-1 family
H4O14_15585	COG2610	gluconate transmembrane transporter activity
H4O14_15590	COG3835	regulator
H4O14_15595	COG1585	Membrane protein implicated in regulation of membrane protease activity
H4O14_15600	COG2268	Band 7 protein
H4O14_15615	COG3212	peptidase
H4O14_15620	COG3850	Histidine kinase
H4O14_15620	COG5002	protein histidine kinase activity
H4O14_15625	COG0745	RESPONSE REGULATOR receiver
H4O14_15630	COG0584	glycerophosphoryl diester phosphodiesterase
H4O14_15640	COG4335	DNA alkylation repair
H4O14_15650	COG3876	Protein conserved in bacteria
H4O14_15655	COG1472	Belongs to the glycosyl hydrolase 3 family
H4O14_15660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4O14_15670	COG1263	PTS System
H4O14_15670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_15675	COG1737	Transcriptional regulator
H4O14_15680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4O14_15685	COG2304	oxidoreductase activity
H4O14_15690	COG2310	stress, protein
H4O14_15695	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_15705	COG1404	Belongs to the peptidase S8 family
H4O14_15745	COG1116	anion transmembrane transporter activity
H4O14_15745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4O14_15755	COG0488	(ABC) transporter
H4O14_15760	COG0723	plastoquinol--plastocyanin reductase activity
H4O14_15760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_15765	COG2824	Alkylphosphonate utilization operon protein PhnA
H4O14_15770	COG1278	Cold shock
H4O14_15785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4O14_15790	COG2188	Transcriptional regulator
H4O14_15795	COG0363	glucosamine-6-phosphate deaminase activity
H4O14_15800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4O14_15805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H4O14_15805	COG1263	PTS System
H4O14_15820	COG2271	Major facilitator Superfamily
H4O14_15825	COG0277	FAD linked oxidase domain protein
H4O14_15830	COG3871	stress protein (general stress protein 26)
H4O14_15865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_15870	COG0765	amino acid transport
H4O14_15875	COG1126	abc transporter atp-binding protein
H4O14_15880	COG2364	Membrane
H4O14_15885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4O14_15895	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4O14_15920	COG1174	glycine betaine transport
H4O14_15925	COG0517	IMP dehydrogenase activity
H4O14_15925	COG1125	glycine betaine transport
H4O14_15935	COG1363	Peptidase, m42
H4O14_15945	COG1834	amidinotransferase
H4O14_15950	COG4191	Histidine kinase
H4O14_15960	COG4608	Belongs to the ABC transporter superfamily
H4O14_15965	COG0791	NLP P60 protein
H4O14_15970	COG4948	Mandelate Racemase Muconate Lactonizing
H4O14_15975	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4O14_15980	COG4166	transmembrane transport
H4O14_15985	COG0444	Belongs to the ABC transporter superfamily
H4O14_15990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_15995	COG0601	transmembrane transport
H4O14_16000	COG2362	D-Aminopeptidase
H4O14_16005	COG2050	protein possibly involved in aromatic compounds catabolism
H4O14_16010	COG1024	Enoyl-CoA hydratase
H4O14_16020	COG0183	Belongs to the thiolase family
H4O14_16025	COG1960	acyl-CoA dehydrogenase activity
H4O14_16030	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_16035	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_16040	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_16045	COG2814	Major facilitator Superfamily
H4O14_16050	COG1960	acyl-CoA dehydrogenase activity
H4O14_16060	COG1595	DNA-templated transcription, initiation
H4O14_16065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4O14_16075	COG2322	membrane
H4O14_16080	COG3829	transcription factor binding
H4O14_16080	COG3290	protein histidine kinase activity
H4O14_16090	COG1960	acyl-CoA dehydrogenase activity
H4O14_16095	COG0604	alcohol dehydrogenase
H4O14_16105	COG1126	abc transporter atp-binding protein
H4O14_16110	COG0765	amino acid transport
H4O14_16130	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_16135	COG2706	6-phosphogluconolactonase activity
H4O14_16140	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4O14_16145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4O14_16160	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_16165	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H4O14_16170	COG1131	(ABC) transporter
H4O14_16190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4O14_16210	COG1131	(ABC) transporter
H4O14_16215	COG1725	Transcriptional regulator
H4O14_16220	COG4257	antibiotic catabolic process
H4O14_16225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H4O14_16225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4O14_16230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H4O14_16235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4O14_16245	COG2186	Transcriptional regulator
H4O14_16250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H4O14_16260	COG2721	sulfolactate sulfo-lyase activity
H4O14_16265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4O14_16280	COG0613	PHP domain protein
H4O14_16285	COG4778	phosphonate C-P lyase system protein PhnL
H4O14_16295	COG3454	Phosphonate metabolism
H4O14_16300	COG4107	phosphonate C-P lyase system protein PhnK
H4O14_16305	COG3627	carbon phosphorus lyase activity
H4O14_16325	COG3639	organic phosphonate transmembrane transporter activity
H4O14_16330	COG3639	organic phosphonate transmembrane transporter activity
H4O14_16335	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H4O14_16345	COG2188	Transcriptional regulator
H4O14_16355	COG5578	integral membrane protein
H4O14_16360	COG0673	inositol 2-dehydrogenase activity
H4O14_16375	COG0395	ABC-type sugar transport system, permease component
H4O14_16390	COG1175	transmembrane transport
H4O14_16400	COG0673	inositol 2-dehydrogenase activity
H4O14_16420	COG1940	carbohydrate kinase activity
H4O14_16425	COG1357	PFAM Pentapeptide repeats (8 copies)
H4O14_16430	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H4O14_16440	COG1476	TRANSCRIPTIONal
H4O14_16450	COG0596	Alpha beta hydrolase
H4O14_16460	COG5444	nuclease activity
H4O14_16480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O14_16485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4O14_16490	COG1061	Type III restriction enzyme res subunit
H4O14_16500	COG0494	nUDIX hydrolase
H4O14_16515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H4O14_16545	COG3226	Transcriptional regulator
H4O14_16555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4O14_16565	COG0656	L-ascorbic acid biosynthetic process
H4O14_16570	COG2814	Major facilitator Superfamily
H4O14_16575	COG1733	regulation of RNA biosynthetic process
H4O14_16590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4O14_16595	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H4O14_16605	COG1587	Uroporphyrinogen-III synthase
H4O14_16630	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_16635	COG1312	Catalyzes the dehydration of D-mannonate
H4O14_16640	COG1904	glucuronate isomerase
H4O14_16670	COG0800	Aldolase
H4O14_16675	COG1609	Transcriptional regulator
H4O14_16685	COG1349	DNA-binding transcription factor activity
H4O14_16695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4O14_16700	COG0805	protein transport
H4O14_16710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4O14_16715	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_16825	COG4974	Belongs to the 'phage' integrase family
H4O14_16835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4O14_16850	COG2358	TRAP transporter, solute receptor (TAXI family
H4O14_16860	COG3832	glyoxalase III activity
H4O14_16870	COG1063	alcohol dehydrogenase
H4O14_16890	COG3764	Sortase (surface protein transpeptidase)
H4O14_16900	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_16905	COG5577	PFAM Coat F domain
H4O14_16945	COG0861	Integral membrane protein TerC family
H4O14_16975	COG4682	membrane
H4O14_16980	COG0726	polysaccharide deacetylase
H4O14_16985	COG0726	polysaccharide deacetylase
H4O14_17015	COG1846	Transcriptional regulator
H4O14_17020	COG0531	amino acid
H4O14_17030	COG1607	acyl-coa hydrolase
H4O14_17070	COG2211	Major facilitator Superfamily
H4O14_17090	COG0456	acetyltransferase
H4O14_17105	COG2197	response regulator
H4O14_17110	COG4585	Histidine kinase
H4O14_17115	COG3239	Fatty acid desaturase
H4O14_17120	COG2318	DinB family
H4O14_17130	COG2514	catechol 2,3-dioxygenase activity
H4O14_17150	COG0697	spore germination
H4O14_17155	COG0772	Belongs to the SEDS family
H4O14_17165	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H4O14_17180	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_17190	COG0772	Belongs to the SEDS family
H4O14_17195	COG0586	Pfam SNARE associated Golgi protein
H4O14_17200	COG1366	Belongs to the anti-sigma-factor antagonist family
H4O14_17215	COG2207	Transcriptional regulator
H4O14_17215	COG3708	Transcriptional regulator
H4O14_17220	COG0588	phosphoglycerate mutase activity
H4O14_17245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4O14_17255	COG1917	Cupin 2, conserved barrel domain protein
H4O14_17255	COG4977	sequence-specific DNA binding
H4O14_17260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H4O14_17295	COG0626	cystathionine gamma-synthase activity
H4O14_17300	COG0626	cystathionine gamma-synthase activity
H4O14_17310	COG2382	esterase
H4O14_17315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H4O14_17320	COG2153	protein acetylation
H4O14_17330	COG2323	membrane
H4O14_17345	COG0210	DNA helicase
H4O14_17400	COG0438	transferase activity, transferring glycosyl groups
H4O14_17405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H4O14_17410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4O14_17415	COG0438	transferase activity, transferring glycosyl groups
H4O14_17425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_17430	COG0438	transferase activity, transferring glycosyl groups
H4O14_17435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4O14_17450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H4O14_17455	COG2733	membrane
H4O14_17460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4O14_17470	COG2104	thiamine diphosphate biosynthetic process
H4O14_17475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4O14_17480	COG0352	thiamine-phosphate diphosphorylase activity
H4O14_17485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4O14_17490	COG0569	domain protein
H4O14_17490	COG0475	glutathione-regulated potassium exporter activity
H4O14_17495	COG2239	Acts as a magnesium transporter
H4O14_17500	COG0772	Belongs to the SEDS family
H4O14_17505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4O14_17510	COG0564	pseudouridine synthase activity
H4O14_17515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4O14_17520	COG2357	RelA SpoT domain protein
H4O14_17530	COG4116	CYTH
H4O14_17535	COG0741	lytic transglycosylase activity
H4O14_17540	COG2346	COG2346, Truncated hemoglobins
H4O14_17545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4O14_17555	COG1164	Oligoendopeptidase f
H4O14_17565	COG4469	Competence protein
H4O14_17570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4O14_17575	COG4862	establishment of competence for transformation
H4O14_17580	COG0861	Integral membrane protein TerC family
H4O14_17585	COG1393	Belongs to the ArsC family
H4O14_17590	COG0456	acetyltransferase
H4O14_17605	COG4608	Belongs to the ABC transporter superfamily
H4O14_17610	COG0444	Belongs to the ABC transporter superfamily
H4O14_17615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_17620	COG0601	transmembrane transport
H4O14_17635	COG0180	Tryptophanyl-tRNA synthetase
H4O14_17645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O14_17650	COG0601	transmembrane transport
H4O14_17660	COG4608	Belongs to the ABC transporter superfamily
H4O14_17665	COG0444	Belongs to the ABC transporter superfamily
H4O14_17670	COG5504	Zn-dependent protease
H4O14_17675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4O14_17680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4O14_17700	COG1744	ABC transporter substrate-binding protein PnrA-like
H4O14_17710	COG2267	carboxylic ester hydrolase activity
H4O14_17725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4O14_17730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4O14_17735	COG0505	Belongs to the CarA family
H4O14_17745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4O14_17750	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4O14_17755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4O14_17760	COG2151	metal-sulfur cluster biosynthetic enzyme
H4O14_17765	COG1073	alpha beta
H4O14_17770	COG0561	phosphatase activity
H4O14_17790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_17795	COG1307	EDD domain protein, DegV family
H4O14_17805	COG0840	transmembrane signaling receptor activity
H4O14_17810	COG1744	ABC transporter substrate-binding protein PnrA-like
H4O14_17815	COG2996	Protein conserved in bacteria
H4O14_17825	COG1666	GTP binding
H4O14_17830	COG0646	methionine synthase
H4O14_17830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4O14_17835	COG0646	methionine synthase
H4O14_17835	COG1410	methionine synthase
H4O14_17840	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_17855	COG1227	inorganic diphosphatase activity
H4O14_17885	COG1874	Beta-galactosidase
H4O14_17885	COG0366	Alpha amylase catalytic
H4O14_17890	COG3833	ABC-type maltose transport systems, permease component
H4O14_17895	COG1175	transmembrane transport
H4O14_17900	COG2182	Extracellular solute-binding protein
H4O14_17910	COG1113	amino acid transport
H4O14_17920	COG2207	Transcriptional regulator
H4O14_17920	COG1917	Cupin 2, conserved barrel domain protein
H4O14_17925	COG0534	Mate efflux family protein
H4O14_17930	COG0004	ammonium transporteR
H4O14_17935	COG1464	Belongs to the NlpA lipoprotein family
H4O14_17955	COG1562	ergosterol biosynthetic process
H4O14_17965	COG0367	asparagine synthase
H4O14_17980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4O14_17990	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4O14_17995	COG0084	hydrolase, TatD family'
H4O14_18005	COG2311	Membrane
H4O14_18010	COG1510	regulation of RNA biosynthetic process
H4O14_18015	COG1125	glycine betaine transport
H4O14_18015	COG0517	IMP dehydrogenase activity
H4O14_18020	COG1174	glycine betaine transport
H4O14_18025	COG1732	Glycine betaine
H4O14_18030	COG1174	glycine betaine transport
H4O14_18060	COG1609	Transcriptional regulator
H4O14_18065	COG3459	Glycosyltransferase 36 associated
H4O14_18075	COG1653	transport
H4O14_18085	COG0395	ABC-type sugar transport system, permease component
H4O14_18120	COG0419	ATPase involved in DNA repair
H4O14_18125	COG0420	3'-5' exonuclease activity
H4O14_18130	COG1074	ATP-dependent DNA helicase activity
H4O14_18135	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H4O14_18140	COG2814	Major facilitator Superfamily
H4O14_18145	COG0681	Belongs to the peptidase S26 family
H4O14_18150	COG0398	Pfam SNARE associated Golgi protein
H4O14_18160	COG4903	ComK protein
H4O14_18170	COG2224	Isocitrate lyase
H4O14_18175	COG0501	Belongs to the peptidase M48B family
H4O14_18185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4O14_18190	COG1396	sequence-specific DNA binding
H4O14_18200	COG1024	Enoyl-CoA hydratase
H4O14_18205	COG0318	PFAM AMP-dependent synthetase and ligase
H4O14_18240	COG0095	Lipoate-protein ligase
H4O14_18245	COG1234	tRNA 3'-trailer cleavage
H4O14_18260	COG1940	carbohydrate kinase activity
H4O14_18260	COG1846	Transcriptional regulator
H4O14_18270	COG0673	inositol 2-dehydrogenase activity
H4O14_18280	COG0753	catalase activity
H4O14_18305	COG0395	ABC-type sugar transport system, permease component
H4O14_18325	COG0395	ABC-type sugar transport system, permease component
H4O14_18355	COG5578	integral membrane protein
H4O14_18365	COG1609	Transcriptional regulator
H4O14_18370	COG1511	domain protein
H4O14_18375	COG1309	transcriptional regulator
H4O14_18380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H4O14_18385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4O14_18390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4O14_18395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_18400	COG2329	Antibiotic biosynthesis monooxygenase
H4O14_18405	COG3069	C4-dicarboxylate transmembrane transporter activity
H4O14_18410	COG0671	phosphoesterase, PA-phosphatase related
H4O14_18415	COG1473	amidohydrolase
H4O14_18425	COG4473	ABC transporter
H4O14_18430	COG1131	(ABC) transporter
H4O14_18435	COG0537	adenosine 5'-monophosphoramidase activity
H4O14_18440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4O14_18455	COG4980	gas vesicle protein
H4O14_18460	COG1846	Transcriptional regulator
H4O14_18490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4O14_18500	COG3481	metal-dependent phosphohydrolase, HD sub domain
H4O14_18505	COG2814	Major facilitator Superfamily
H4O14_18510	COG4717	serine-type aminopeptidase activity
H4O14_18515	COG0420	3'-5' exonuclease activity
H4O14_18520	COG1668	transmembrane transport
H4O14_18525	COG4152	abc transporter atp-binding protein
H4O14_18535	COG1024	Enoyl-CoA hydratase
H4O14_18540	COG0183	Belongs to the thiolase family
H4O14_18545	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O14_18550	COG1960	acyl-CoA dehydrogenase activity
H4O14_18585	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H4O14_18585	COG1605	Chorismate mutase
H4O14_18600	COG0529	Catalyzes the synthesis of activated sulfate
H4O14_18630	COG1113	amino acid transport
H4O14_18635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4O14_18640	COG0561	phosphatase activity
H4O14_18655	COG0561	phosphatase activity
H4O14_18660	COG3679	Belongs to the UPF0342 family
H4O14_18670	COG0189	ligase activity
H4O14_18690	COG2508	Transcriptional regulator
H4O14_18695	COG3842	ATPase activity
H4O14_18715	COG1126	abc transporter atp-binding protein
H4O14_18720	COG0765	amino acid transport
H4O14_18725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O14_18730	COG0702	epimerase
H4O14_18735	COG1132	(ABC) transporter
H4O14_18740	COG1132	(ABC) transporter
H4O14_18755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O14_18760	COG0589	response to stress
H4O14_18765	COG0840	transmembrane signaling receptor activity
H4O14_18770	COG1757	Na H antiporter
H4O14_18780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O14_18785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O14_18810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H4O14_18815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4O14_18820	COG0668	transmembrane transport
H4O14_18845	COG1764	response to oxidative stress
H4O14_18895	COG0628	permease
H4O14_18930	COG0402	S-adenosylhomocysteine deaminase activity
H4O14_18935	COG0583	DNA-binding transcription factor activity
H4O14_18945	COG2233	PERMEase
H4O14_18950	COG0640	Transcriptional regulator
H4O14_18955	COG1329	Transcriptional regulator
H4O14_18960	COG1295	ribonuclease BN
H4O14_18965	COG0671	phosphoesterase, PA-phosphatase related
H4O14_18970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4O14_18975	COG3829	transcription factor binding
H4O14_18985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_18990	COG1621	beta-fructofuranosidase activity
H4O14_19000	COG0395	ABC-type sugar transport system, permease component
H4O14_19005	COG4209	transmembrane transport
H4O14_19030	COG5646	InterPro IPR014922
H4O14_19040	COG4753	response regulator
H4O14_19040	COG2207	Transcriptional regulator
H4O14_19050	COG0745	RESPONSE REGULATOR receiver
H4O14_19055	COG5002	protein histidine kinase activity
H4O14_19060	COG4149	molybdate abc transporter
H4O14_19065	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4O14_19070	COG1999	signal sequence binding
H4O14_19085	COG2738	Putative neutral zinc metallopeptidase
H4O14_19090	COG3339	Conserved Protein
H4O14_19095	COG1742	UPF0060 membrane protein
H4O14_19100	COG2508	Transcriptional regulator
H4O14_19105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4O14_19110	COG1012	belongs to the aldehyde dehydrogenase family
H4O14_19115	COG0506	proline dehydrogenase activity
H4O14_19135	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H4O14_19140	COG0640	Transcriptional regulator
H4O14_19155	COG0492	ferredoxin-NADP+ reductase activity
H4O14_19175	COG2719	SpoVR family
H4O14_19195	COG2814	Major facilitator Superfamily
H4O14_19205	COG1959	2 iron, 2 sulfur cluster binding
H4O14_19220	COG1397	ADP-ribosylglycohydrolase
H4O14_19225	COG1609	Transcriptional regulator
H4O14_19240	COG0395	ABC-type sugar transport system, permease component
H4O14_19245	COG4209	transmembrane transport
H4O14_19250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O14_19275	COG0431	NADPH-dependent FMN reductase
H4O14_19280	COG2197	response regulator
H4O14_19285	COG4585	Histidine kinase
H4O14_19285	COG2203	Gaf domain
H4O14_19290	COG1028	Short-chain dehydrogenase reductase Sdr
H4O14_19295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4O14_19300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H4O14_19310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H4O14_19315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H4O14_19320	COG3153	acetyltransferase
H4O14_19320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O14_19325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4O14_19330	COG0517	IMP dehydrogenase activity
H4O14_19355	COG2801	Transposase and inactivated derivatives
H4O14_19365	COG0564	pseudouridine synthase activity
H4O14_19370	COG0456	acetyltransferase
H4O14_19375	COG3764	Sortase (surface protein transpeptidase)
H4O14_19380	COG0656	L-ascorbic acid biosynthetic process
H4O14_19385	COG2217	Heavy metal translocating P-type atpase
H4O14_19390	COG2259	Doxx family
H4O14_19395	COG1404	Belongs to the peptidase S8 family
H4O14_19400	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4O14_19405	COG0778	Nitroreductase
H4O14_19410	COG0306	phosphate transporter
H4O14_19415	COG1392	Phosphate transport regulator
H4O14_19420	COG1301	dicarboxylic acid transport
H4O14_19435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4O14_19440	COG3290	protein histidine kinase activity
H4O14_19450	COG2271	Major facilitator Superfamily
H4O14_19455	COG0659	secondary active sulfate transmembrane transporter activity
H4O14_19465	COG0395	ABC-type sugar transport system, permease component
H4O14_19470	COG1175	transmembrane transport
H4O14_19475	COG1653	transport
H4O14_19495	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H4O14_19505	COG0640	Transcriptional regulator
H4O14_19515	COG0745	RESPONSE REGULATOR receiver
H4O14_19520	COG2205	protein histidine kinase activity
H4O14_19525	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H4O14_19525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H4O14_19540	COG1486	melibiose metabolic process
H4O14_19545	COG1447	Phosphotransferase system cellobiose-specific component IIA
H4O14_19550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_19555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H4O14_19560	COG2323	membrane
H4O14_19575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4O14_19610	COG2766	serine protein kinase
H4O14_19615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4O14_19630	COG3382	B3 4 domain protein
H4O14_19640	COG4753	response regulator
H4O14_19640	COG2207	Transcriptional regulator
H4O14_19645	COG2972	Histidine kinase
H4O14_19665	COG4608	Belongs to the ABC transporter superfamily
H4O14_19680	COG1715	Restriction endonuclease
H4O14_19690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity