locus-tag	class	description
M662_00010	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M662_00015	COG4241	membrane
M662_00030	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M662_00035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M662_00045	COG4166	transmembrane transport
M662_00050	COG1017	nitric oxide dioxygenase activity
M662_00050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M662_00055	COG1959	2 iron, 2 sulfur cluster binding
M662_00060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M662_00065	COG0629	single-stranded DNA binding
M662_00070	COG0360	Binds together with S18 to 16S ribosomal RNA
M662_00075	COG0012	GTP binding
M662_00080	COG4481	Protein conserved in bacteria
M662_00085	COG0668	transmembrane transport
M662_00090	COG3949	Membrane
M662_00105	COG1475	DNA binding
M662_00110	COG1192	Involved in chromosome partitioning
M662_00115	COG1475	DNA binding
M662_00120	COG2197	response regulator
M662_00125	COG4585	Histidine kinase
M662_00135	COG1131	(ABC) transporter
M662_00145	COG1533	DNA photolyase activity
M662_00150	COG1028	Short-chain dehydrogenase reductase Sdr
M662_00165	COG0357	Ribosomal RNA small subunit methyltransferase G
M662_00170	COG0445	tRNA wobble uridine modification
M662_00175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M662_00180	COG1847	R3H domain protein
M662_00185	COG0706	membrane insertase activity
M662_00190	COG0594	ribonuclease P activity
M662_00195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M662_00200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M662_00205	COG0592	DNA-directed DNA polymerase activity
M662_00210	COG2501	S4 domain
M662_00215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M662_00225	COG0187	DNA topoisomerase II activity
M662_00230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M662_00235	COG3437	response regulator, receiver
M662_00245	COG0517	IMP dehydrogenase activity
M662_00245	COG0516	GMP reductase activity
M662_00260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M662_00265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M662_00275	COG1733	regulation of RNA biosynthetic process
M662_00280	COG2814	Major facilitator Superfamily
M662_00295	COG1428	Deoxynucleoside kinase
M662_00300	COG1428	Deoxynucleoside kinase
M662_00310	COG4149	molybdate abc transporter
M662_00315	COG0725	ABC transporter, periplasmic molybdate-binding protein
M662_00335	COG1012	belongs to the aldehyde dehydrogenase family
M662_00345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M662_00350	COG2233	PERMEase
M662_00360	COG0693	protein deglycase activity
M662_00370	COG3858	chitin binding
M662_00370	COG1388	LysM domain
M662_00375	COG0590	tRNA wobble adenosine to inosine editing
M662_00385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M662_00390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M662_00395	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M662_00430	COG1982	Orn Lys Arg decarboxylase major
M662_00435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M662_00440	COG3870	Protein conserved in bacteria
M662_00445	COG1728	Protein conserved in bacteria
M662_00450	COG0470	DNA polymerase III
M662_00455	COG1774	PSP1 C-terminal conserved region
M662_00460	COG4467	Involved in initiation control of chromosome replication
M662_00465	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M662_00470	COG2827	Endonuclease containing a URI domain
M662_00475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M662_00480	COG2002	toxin-antitoxin pair type II binding
M662_00490	COG0084	hydrolase, TatD family'
M662_00495	COG3583	domain protein
M662_00495	COG3584	3D domain protein
M662_00505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M662_00515	COG4466	Protein conserved in bacteria
M662_00530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M662_00535	COG2088	sporulation resulting in formation of a cellular spore
M662_00540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M662_00545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M662_00550	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M662_00555	COG0193	aminoacyl-tRNA hydrolase activity
M662_00565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M662_00570	COG2002	toxin-antitoxin pair type II binding
M662_00575	COG2244	polysaccharide biosynthetic process
M662_00580	COG3956	TIGRFAM MazG family protein
M662_00585	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M662_00605	COG1098	S1 RNA binding domain
M662_00620	COG2208	phosphoserine phosphatase activity
M662_00625	COG2304	oxidoreductase activity
M662_00630	COG0515	serine threonine protein kinase
M662_00635	COG0037	tRNA processing
M662_00645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M662_00655	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M662_00660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M662_00665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M662_00670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M662_00675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M662_00680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M662_00760	COG1285	pathogenesis
M662_00770	COG3880	PFAM UvrB UvrC protein
M662_00775	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M662_00780	COG0542	response to heat
M662_00785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M662_00795	COG4956	integral membrane protein (PIN domain superfamily)
M662_00800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M662_00800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M662_00805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M662_00810	COG1045	serine acetyltransferase
M662_00815	COG0215	cysteine-tRNA ligase activity
M662_00825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M662_00830	COG3688	RNA-binding protein containing a PIN domain
M662_00840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M662_00845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M662_00850	COG0250	Participates in transcription elongation, termination and antitermination
M662_00855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M662_00860	COG0081	regulation of translation
M662_00865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M662_00875	COG2813	Specifically methylates the guanine in position
M662_00880	COG0085	RNA polymerase activity
M662_00885	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M662_00890	COG1358	cellular component organization or biogenesis
M662_00895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M662_00900	COG0049	tRNA binding
M662_00905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M662_00910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M662_00915	COG0051	transcription antitermination factor activity, RNA binding
M662_00920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M662_00925	COG0088	Forms part of the polypeptide exit tunnel
M662_00930	COG0089	rRNA binding
M662_00935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M662_00940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M662_00950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M662_00955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M662_00960	COG0255	Belongs to the universal ribosomal protein uL29 family
M662_00965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M662_00970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M662_00975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M662_00985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M662_00990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M662_00995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M662_01000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M662_01005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M662_01010	COG1841	ribosomal large subunit assembly
M662_01015	COG0200	Binds to the 23S rRNA
M662_01020	COG0201	protein transport
M662_01025	COG0563	adenylate kinase activity
M662_01030	COG0024	Methionine aminopeptidase
M662_01035	COG2163	COG2163 Ribosomal protein L14E L6E L27E
M662_01040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M662_01045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M662_01050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M662_01055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M662_01065	COG0203	ribosomal protein L17
M662_01070	COG1122	ATPase activity
M662_01075	COG1122	ATPase activity
M662_01080	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M662_01085	COG0101	tRNA pseudouridine synthase activity
M662_01090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M662_01095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M662_01100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M662_01110	COG3414	Phosphotransferase system galactitol-specific IIB component
M662_01115	COG3775	system Galactitol-specific IIC component
M662_01120	COG1063	alcohol dehydrogenase
M662_01125	COG1063	alcohol dehydrogenase
M662_01130	COG0860	N-Acetylmuramoyl-L-alanine amidase
M662_01135	COG0489	protein tyrosine kinase activity
M662_01145	COG2194	sulfuric ester hydrolase activity
M662_01150	COG0726	polysaccharide deacetylase
M662_01235	COG1595	DNA-templated transcription, initiation
M662_01240	COG5662	AntiSigma factor
M662_01245	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M662_01250	COG4856	YbbR-like protein
M662_01260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M662_01265	COG0772	Belongs to the SEDS family
M662_01295	COG1510	regulation of RNA biosynthetic process
M662_01300	COG4988	ABC transporter
M662_01305	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M662_01330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M662_01350	COG0640	Transcriptional regulator
M662_01360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M662_01365	COG0196	riboflavin kinase activity
M662_01380	COG0656	L-ascorbic acid biosynthetic process
M662_01390	COG3773	Cell wall hydrolase
M662_01395	COG1115	amino acid carrier protein
M662_01400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M662_01405	COG1725	Transcriptional regulator
M662_01410	COG1131	(ABC) transporter
M662_01420	COG1595	DNA-templated transcription, initiation
M662_01435	COG5001	Diguanylate cyclase
M662_01435	COG3300	MHYT domain
M662_01440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M662_01445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_01450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_01455	COG0492	ferredoxin-NADP+ reductase activity
M662_01460	COG1410	methionine synthase
M662_01460	COG0646	methionine synthase
M662_01465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M662_01465	COG0646	methionine synthase
M662_01470	COG0626	cystathionine gamma-synthase activity
M662_01475	COG0626	cystathionine gamma-synthase activity
M662_01490	COG1294	oxidase, subunit
M662_01495	COG1271	oxidase subunit
M662_01500	COG2226	methyltransferase
M662_01510	COG1959	2 iron, 2 sulfur cluster binding
M662_01515	COG0778	Nitroreductase
M662_01520	COG2814	Major facilitator Superfamily
M662_01535	COG0157	Belongs to the NadC ModD family
M662_01540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M662_01545	COG1104	cysteine desulfurase activity
M662_01550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M662_01555	COG1120	ATPase activity
M662_01560	COG1970	mechanosensitive ion channel activity
M662_01565	COG2814	Major facilitator Superfamily
M662_01575	COG1413	lyase activity
M662_01580	COG1131	(ABC) transporter
M662_01585	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M662_01595	COG2116	formate transmembrane transporter activity
M662_01605	COG0789	Transcriptional regulator
M662_01610	COG1388	LysM domain
M662_01610	COG3584	3D domain protein
M662_01615	COG1028	Short-chain dehydrogenase reductase Sdr
M662_01620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M662_01645	COG0791	NLP P60 protein
M662_01645	COG0741	lytic transglycosylase activity
M662_01655	COG1621	beta-fructofuranosidase activity
M662_01660	COG0628	permease
M662_01665	COG5553	Cysteine dioxygenase type I
M662_01670	COG0697	spore germination
M662_01680	COG0583	DNA-binding transcription factor activity
M662_01695	COG0583	DNA-binding transcription factor activity
M662_01700	COG2202	Pas domain
M662_01700	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_01705	COG1960	acyl-CoA dehydrogenase activity
M662_01710	COG0693	protein deglycase activity
M662_01720	COG4086	secreted protein
M662_01725	COG1999	signal sequence binding
M662_01730	COG0596	Alpha beta hydrolase
M662_01755	COG0626	cystathionine gamma-synthase activity
M662_01765	COG1595	DNA-templated transcription, initiation
M662_01805	COG1595	DNA-templated transcription, initiation
M662_01815	COG0004	ammonium transporteR
M662_01820	COG0347	Belongs to the P(II) protein family
M662_01825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M662_01830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M662_01835	COG2226	methyltransferase
M662_01845	COG3871	stress protein (general stress protein 26)
M662_01855	COG2153	protein acetylation
M662_01885	COG1834	amidinotransferase
M662_01890	COG0436	Aminotransferase
M662_01895	COG0446	pyridine nucleotide-disulphide oxidoreductase
M662_01900	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M662_01905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M662_01910	COG3275	phosphorelay sensor kinase activity
M662_01915	COG3279	Response regulator of the LytR AlgR family
M662_01920	COG1966	Carbon starvation protein
M662_01935	COG1597	lipid kinase activity
M662_01940	COG5506	Protein of unknown function (DUF1694)
M662_01955	COG0741	lytic transglycosylase activity
M662_01960	COG0431	NADPH-dependent FMN reductase
M662_01970	COG1764	response to oxidative stress
M662_02005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M662_02015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M662_02030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M662_02045	COG4134	Bacterial extracellular solute-binding protein
M662_02060	COG0840	transmembrane signaling receptor activity
M662_02065	COG1744	ABC transporter substrate-binding protein PnrA-like
M662_02070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M662_02085	COG0534	Mate efflux family protein
M662_02100	COG1597	lipid kinase activity
M662_02105	COG1846	Transcriptional regulator
M662_02110	COG0488	(ABC) transporter
M662_02140	COG0513	Belongs to the DEAD box helicase family
M662_02145	COG0705	Rhomboid family
M662_02150	COG0736	holo-[acyl-carrier-protein] synthase activity
M662_02155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M662_02155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M662_02160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M662_02170	COG0864	Transcriptional regulator
M662_02175	COG2337	Toxic component of a toxin-antitoxin (TA) module
M662_02180	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_02185	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_02190	COG2172	sigma factor antagonist activity
M662_02195	COG2208	phosphoserine phosphatase activity
M662_02200	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_02205	COG2172	sigma factor antagonist activity
M662_02210	COG1191	sigma factor activity
M662_02220	COG2183	response to ionizing radiation
M662_02230	COG3091	SprT-like family
M662_02320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M662_02325	COG0802	atpase or kinase
M662_02330	COG1214	PFAM Peptidase M22, glycoprotease
M662_02335	COG0456	acetyltransferase
M662_02340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M662_02345	COG0488	(ABC) transporter
M662_02350	COG0315	cyclic pyranopterin monophosphate synthase activity
M662_02355	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M662_02360	COG1028	Short-chain dehydrogenase reductase Sdr
M662_02365	COG2814	Major facilitator Superfamily
M662_02375	COG1266	CAAX protease self-immunity
M662_02380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M662_02385	COG0459	protein refolding
M662_02410	COG1228	amidohydrolase
M662_02425	COG0583	DNA-binding transcription factor activity
M662_02440	COG2207	Transcriptional regulator
M662_02440	COG1609	Transcriptional regulator
M662_02450	COG1510	regulation of RNA biosynthetic process
M662_02455	COG1012	belongs to the aldehyde dehydrogenase family
M662_02465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M662_02475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M662_02490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M662_02495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M662_02505	COG1757	Na H antiporter
M662_02510	COG1757	Na H antiporter
M662_02515	COG0252	asparaginase activity
M662_02520	COG1027	Aspartate ammonia-lyase
M662_02525	COG1396	sequence-specific DNA binding
M662_02530	COG0252	asparaginase activity
M662_02545	COG0745	RESPONSE REGULATOR receiver
M662_02550	COG5002	protein histidine kinase activity
M662_02550	COG3850	Histidine kinase
M662_02555	COG1999	signal sequence binding
M662_02565	COG2832	Protein of unknown function (DUF454)
M662_02570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M662_02585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M662_02590	COG2079	MmgE PrpD family protein
M662_02595	COG0372	Belongs to the citrate synthase family
M662_02605	COG0702	epimerase
M662_02610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M662_02615	COG1368	sulfuric ester hydrolase activity
M662_02620	COG2746	aminoglycoside 3-N-acetyltransferase activity
M662_02630	COG0471	metal ion transport
M662_02630	COG3273	potassium ion transport
M662_02635	COG3459	Glycosyltransferase 36 associated
M662_02640	COG1472	Belongs to the glycosyl hydrolase 3 family
M662_02645	COG1653	transport
M662_02650	COG1175	transmembrane transport
M662_02655	COG0395	ABC-type sugar transport system, permease component
M662_02665	COG1609	Transcriptional regulator
M662_02670	COG0772	Belongs to the SEDS family
M662_02680	COG0772	Belongs to the SEDS family
M662_02685	COG1695	Transcriptional regulator
M662_02690	COG3479	Phenolic acid decarboxylase
M662_02710	COG0205	6-phosphofructokinase activity
M662_02715	COG5505	Protein of unknown function (DUF819)
M662_02720	COG2124	cytochrome p450
M662_02725	COG3588	fructose-bisphosphate aldolase
M662_02730	COG0747	negative chemotaxis
M662_02735	COG0601	transmembrane transport
M662_02745	COG0444	Belongs to the ABC transporter superfamily
M662_02750	COG4608	Belongs to the ABC transporter superfamily
M662_02760	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M662_02760	COG2508	Transcriptional regulator
M662_02765	COG1228	amidohydrolase
M662_02775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M662_02780	COG0673	inositol 2-dehydrogenase activity
M662_02790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M662_02795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M662_02800	COG0745	RESPONSE REGULATOR receiver
M662_02805	COG5002	protein histidine kinase activity
M662_02810	COG0655	NAD(P)H dehydrogenase (quinone) activity
M662_02830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M662_02845	COG4753	response regulator
M662_02845	COG2207	Transcriptional regulator
M662_02850	COG2972	Histidine kinase
M662_02870	COG3250	beta-galactosidase activity
M662_02890	COG1686	Belongs to the peptidase S11 family
M662_02900	COG1414	Transcriptional regulator
M662_02905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M662_02910	COG0800	Aldolase
M662_02915	COG4948	Mandelate Racemase Muconate Lactonizing
M662_02920	COG2610	gluconate transmembrane transporter activity
M662_02930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M662_02950	COG0456	acetyltransferase
M662_02955	COG2233	PERMEase
M662_02960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M662_02990	COG0768	penicillin binding
M662_02995	COG0456	acetyltransferase
M662_02995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M662_03005	COG1252	NADH dehydrogenase
M662_03015	COG0346	lactoylglutathione lyase activity
M662_03025	COG1086	Polysaccharide biosynthesis protein
M662_03030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M662_03035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M662_03040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M662_03055	COG2089	acid synthase
M662_03060	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M662_03065	COG0714	Associated with various cellular activities
M662_03070	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M662_03075	COG1305	Transglutaminase-like
M662_03080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M662_03080	COG0519	Catalyzes the synthesis of GMP from XMP
M662_03085	COG2252	PERMEase
M662_03095	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M662_03105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M662_03110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M662_03115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M662_03120	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M662_03125	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M662_03135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M662_03140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M662_03145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M662_03150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M662_03155	COG0138	bifunctional purine biosynthesis protein purh
M662_03160	COG0151	Belongs to the GarS family
M662_03170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M662_03175	COG1470	cell adhesion involved in biofilm formation
M662_03180	COG4496	protein, YerC YecD
M662_03190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M662_03195	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M662_03200	COG0210	DNA helicase
M662_03205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M662_03210	COG4851	CamS sex pheromone cAM373 precursor
M662_03215	COG1012	belongs to the aldehyde dehydrogenase family
M662_03225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M662_03230	COG0154	amidase activity
M662_03235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M662_03240	COG1597	lipid kinase activity
M662_03245	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M662_03250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M662_03370	COG4152	abc transporter atp-binding protein
M662_03375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M662_03380	COG1012	belongs to the aldehyde dehydrogenase family
M662_03385	COG1979	alcohol dehydrogenase
M662_03400	COG0210	DNA helicase
M662_03420	COG3046	protein related to deoxyribodipyrimidine photolyase
M662_03430	COG0415	Belongs to the DNA photolyase family
M662_03435	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M662_03440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_03445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_03455	COG1621	beta-fructofuranosidase activity
M662_03460	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M662_03480	COG5001	Diguanylate cyclase
M662_03480	COG3300	MHYT domain
M662_03485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M662_03495	COG1309	transcriptional regulator
M662_03500	COG0477	Major facilitator Superfamily
M662_03505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M662_03510	COG0747	negative chemotaxis
M662_03515	COG0601	transmembrane transport
M662_03520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M662_03525	COG0444	Belongs to the ABC transporter superfamily
M662_03530	COG4608	Belongs to the ABC transporter superfamily
M662_03535	COG0655	NAD(P)H dehydrogenase (quinone) activity
M662_03540	COG0583	DNA-binding transcription factor activity
M662_03555	COG1785	Belongs to the alkaline phosphatase family
M662_03560	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M662_03580	COG0833	amino acid
M662_03585	COG2040	homocysteine
M662_03595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M662_03600	COG0531	amino acid
M662_03605	COG1012	belongs to the aldehyde dehydrogenase family
M662_03615	COG1846	Transcriptional regulator
M662_03625	COG1902	pentaerythritol trinitrate reductase activity
M662_03625	COG0446	pyridine nucleotide-disulphide oxidoreductase
M662_03670	COG1492	cobalamin metabolic process
M662_03675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M662_03680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_03685	COG1120	ATPase activity
M662_03690	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
M662_03705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M662_03710	COG0406	alpha-ribazole phosphatase activity
M662_03720	COG1114	Component of the transport system for branched-chain amino acids
M662_03725	COG1278	Cold shock
M662_03730	COG1609	Transcriptional regulator
M662_03735	COG1653	transport
M662_03740	COG1175	transmembrane transport
M662_03745	COG0395	ABC-type sugar transport system, permease component
M662_03750	COG1486	melibiose metabolic process
M662_03755	COG3339	Conserved Protein
M662_03765	COG3300	MHYT domain
M662_03765	COG5001	Diguanylate cyclase
M662_03770	COG2197	response regulator
M662_03780	COG0681	Belongs to the peptidase S26 family
M662_03790	COG3227	Zinc metalloprotease (Elastase)
M662_03800	COG1132	(ABC) transporter
M662_03805	COG2207	Transcriptional regulator
M662_03820	COG2076	Multidrug Resistance protein
M662_03825	COG2076	Multidrug Resistance protein
M662_03830	COG2356	endonuclease I
M662_03835	COG2814	Major facilitator Superfamily
M662_03845	COG4536	flavin adenine dinucleotide binding
M662_03870	COG2340	Cysteine-rich secretory protein family
M662_03895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M662_03900	COG1116	anion transmembrane transporter activity
M662_03915	COG1472	Belongs to the glycosyl hydrolase 3 family
M662_03920	COG3876	Protein conserved in bacteria
M662_03925	COG0471	metal ion transport
M662_03945	COG0789	Transcriptional regulator
M662_03955	COG0628	permease
M662_03990	COG0166	Belongs to the GPI family
M662_03995	COG0251	oxidation-reduction process
M662_04005	COG1966	Carbon starvation protein
M662_04015	COG1252	NADH dehydrogenase
M662_04030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M662_04035	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M662_04055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M662_04060	COG3192	ethanolamine utilization protein
M662_04080	COG2323	membrane
M662_04085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M662_04090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M662_04095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M662_04100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M662_04105	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_04120	COG1028	Short-chain dehydrogenase reductase Sdr
M662_04125	COG1250	3-hydroxyacyl-CoA dehydrogenase
M662_04140	COG2045	Belongs to the ComB family
M662_04145	COG1960	acyl-CoA dehydrogenase activity
M662_04150	COG1024	Enoyl-CoA hydratase
M662_04160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M662_04165	COG4336	lyase activity
M662_04170	COG1914	H( )-stimulated, divalent metal cation uptake system
M662_04175	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M662_04180	COG1984	allophanate hydrolase subunit 2
M662_04185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M662_04190	COG4876	unkown
M662_04200	COG4895	conserved protein (DUF2196)
M662_04205	COG0604	alcohol dehydrogenase
M662_04225	COG1288	antiporter activity
M662_04230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M662_04235	COG1876	peptidase activity
M662_04255	COG1077	Cell shape determining protein MreB Mrl
M662_04265	COG2258	MOSC domain
M662_04275	COG2135	peptidase activity
M662_04280	COG1115	amino acid carrier protein
M662_04285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M662_04295	COG1295	ribonuclease BN
M662_04300	COG2217	Heavy metal translocating P-type atpase
M662_04305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M662_04310	COG0765	amino acid transport
M662_04315	COG1121	(ABC) transporter
M662_04320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M662_04325	COG0735	belongs to the Fur family
M662_04330	COG0803	Belongs to the bacterial solute-binding protein 9 family
M662_04335	COG0477	Major facilitator Superfamily
M662_04345	COG2364	Membrane
M662_04355	COG0668	transmembrane transport
M662_04365	COG2056	Na+-H+ antiporter family
M662_04375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M662_04380	COG4191	Histidine kinase
M662_04385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M662_04395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M662_04405	COG0328	RNA-DNA hybrid ribonuclease activity
M662_04410	COG1376	ErfK ybiS ycfS ynhG family protein
M662_04415	COG0788	formyltetrahydrofolate deformylase activity
M662_04420	COG1012	belongs to the aldehyde dehydrogenase family
M662_04445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M662_04460	COG2154	pterin-4-alpha-carbinolamine dehydratase
M662_04465	COG0564	pseudouridine synthase activity
M662_04480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M662_04485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M662_04490	COG1335	isochorismatase
M662_04495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M662_04510	COG2076	Multidrug Resistance protein
M662_04515	COG1309	transcriptional regulator
M662_04560	COG0393	Putative heavy-metal-binding
M662_04580	COG1595	DNA-templated transcription, initiation
M662_04590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M662_04595	COG0134	indole-3-glycerol-phosphate synthase activity
M662_04600	COG0135	phosphoribosylanthranilate isomerase activity
M662_04610	COG0159	tryptophan synthase activity
M662_04615	COG0512	Glutamine amidotransferase of anthranilate synthase
M662_04620	COG0840	transmembrane signaling receptor activity
M662_04635	COG0385	Bile acid
M662_04640	COG0671	phosphoesterase, PA-phosphatase related
M662_04650	COG0602	queuosine metabolic process
M662_04655	COG0720	synthase
M662_04660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M662_04665	COG0137	argininosuccinate synthase activity
M662_04670	COG0165	Argininosuccinate lyase
M662_04690	COG2226	methyltransferase
M662_04695	COG1854	S-ribosylhomocysteine lyase activity
M662_04700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M662_04705	COG0626	cystathionine gamma-synthase activity
M662_04710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M662_04745	COG1228	amidohydrolase
M662_04750	COG1090	epimerase
M662_04755	COG2137	regulation of response to DNA damage stimulus
M662_04760	COG0561	phosphatase activity
M662_04765	COG3711	transcriptional antiterminator
M662_04770	COG1263	PTS System
M662_04770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M662_04770	COG2190	(PTS) system
M662_04780	COG0300	oxidoreductase activity
M662_04805	COG1988	membrane-bound metal-dependent
M662_04810	COG1194	a g-specific adenine glycosylase
M662_04820	COG1388	LysM domain
M662_04820	COG0791	NLP P60 protein
M662_04830	COG3557	Belongs to the UPF0374 family
M662_04835	COG1132	(ABC) transporter
M662_04840	COG4129	membrane
M662_04845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M662_04860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M662_04870	COG2096	Adenosyltransferase
M662_04875	COG0735	belongs to the Fur family
M662_04985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M662_05020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M662_05030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M662_05040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M662_05045	COG0095	Lipoate-protein ligase
M662_05055	COG2766	serine protein kinase
M662_05065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M662_05070	COG0567	Dehydrogenase, E1 component
M662_05075	COG0508	dehydrogenase complex catalyzes the overall conversion of
M662_05090	COG2718	Belongs to the UPF0229 family
M662_05095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M662_05100	COG3402	PFAM membrane-flanked domain
M662_05105	COG3428	Bacterial PH domain
M662_05110	COG2252	PERMEase
M662_05115	COG0697	spore germination
M662_05130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M662_05135	COG0534	Mate efflux family protein
M662_05140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M662_05185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M662_05190	COG0655	NAD(P)H dehydrogenase (quinone) activity
M662_05195	COG1191	sigma factor activity
M662_05210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M662_05220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M662_05220	COG3153	acetyltransferase
M662_05240	COG2719	SpoVR family
M662_05265	COG1028	Short-chain dehydrogenase reductase Sdr
M662_05270	COG1619	proteins homologs of microcin C7 resistance protein MccF
M662_05275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M662_05290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M662_05295	COG0659	secondary active sulfate transmembrane transporter activity
M662_05300	COG0589	response to stress
M662_05310	COG1131	(ABC) transporter
M662_05320	COG0110	maltose O-acetyltransferase activity
M662_05325	COG0024	Methionine aminopeptidase
M662_05330	COG1278	Cold shock
M662_05340	COG2267	carboxylic ester hydrolase activity
M662_05345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M662_05350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M662_05360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M662_05375	COG1247	-acetyltransferase
M662_05380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M662_05385	COG0655	NAD(P)H dehydrogenase (quinone) activity
M662_05395	COG1876	peptidase activity
M662_05400	COG0702	epimerase
M662_05405	COG0114	fumarate hydratase activity
M662_05420	COG3842	ATPase activity
M662_05425	COG2508	Transcriptional regulator
M662_05430	COG1937	Protein conserved in bacteria
M662_05435	COG4399	Belongs to the UPF0754 family
M662_05440	COG3679	Belongs to the UPF0342 family
M662_05445	COG1024	Enoyl-CoA hydratase
M662_05455	COG4152	abc transporter atp-binding protein
M662_05460	COG1668	transmembrane transport
M662_05465	COG0420	3'-5' exonuclease activity
M662_05470	COG4717	serine-type aminopeptidase activity
M662_05485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M662_05505	COG1846	Transcriptional regulator
M662_05520	COG0537	adenosine 5'-monophosphoramidase activity
M662_05525	COG1131	(ABC) transporter
M662_05530	COG4473	ABC transporter
M662_05540	COG1473	amidohydrolase
M662_05550	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M662_05560	COG2329	Antibiotic biosynthesis monooxygenase
M662_05565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M662_05570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M662_05590	COG1609	Transcriptional regulator
M662_05600	COG1234	tRNA 3'-trailer cleavage
M662_05605	COG0095	Lipoate-protein ligase
M662_05610	COG0318	PFAM AMP-dependent synthetase and ligase
M662_05630	COG4903	ComK protein
M662_05640	COG0398	Pfam SNARE associated Golgi protein
M662_05650	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M662_05655	COG1074	ATP-dependent DNA helicase activity
M662_05660	COG1403	HNH endonuclease
M662_05695	COG2311	Membrane
M662_05710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M662_05720	COG0367	asparagine synthase
M662_05725	COG0366	Alpha amylase catalytic
M662_05750	COG1307	EDD domain protein, DegV family
M662_05755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M662_05785	COG0561	phosphatase activity
M662_05790	COG1073	alpha beta
M662_05795	COG2151	metal-sulfur cluster biosynthetic enzyme
M662_05805	COG0314	molybdopterin synthase activity
M662_05810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M662_05830	COG1744	ABC transporter substrate-binding protein PnrA-like
M662_05840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M662_05845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M662_05865	COG0180	Tryptophanyl-tRNA synthetase
M662_05875	COG4166	transmembrane transport
M662_05880	COG0601	transmembrane transport
M662_05885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M662_05890	COG0444	Belongs to the ABC transporter superfamily
M662_05895	COG4608	Belongs to the ABC transporter superfamily
M662_05905	COG0456	acetyltransferase
M662_05910	COG1393	Belongs to the ArsC family
M662_05915	COG0861	Integral membrane protein TerC family
M662_05920	COG4862	establishment of competence for transformation
M662_05930	COG1164	Oligoendopeptidase f
M662_05940	COG2346	COG2346, Truncated hemoglobins
M662_05945	COG4116	CYTH
M662_05950	COG2357	RelA SpoT domain protein
M662_05960	COG0564	pseudouridine synthase activity
M662_05965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M662_05970	COG2239	Acts as a magnesium transporter
M662_05975	COG0475	glutathione-regulated potassium exporter activity
M662_05975	COG0569	domain protein
M662_05990	COG0154	amidase activity
M662_05995	COG1027	Aspartate ammonia-lyase
M662_06035	COG2323	membrane
M662_06045	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M662_06050	COG2382	esterase
M662_06065	COG2076	Multidrug Resistance protein
M662_06070	COG2212	antiporter activity
M662_06080	COG1695	Transcriptional regulator
M662_06085	COG0772	Belongs to the SEDS family
M662_06100	COG0386	Belongs to the glutathione peroxidase family
M662_06125	COG1309	transcriptional regulator
M662_06140	COG1695	Transcriptional regulator
M662_06170	COG1028	Short-chain dehydrogenase reductase Sdr
M662_06175	COG1012	belongs to the aldehyde dehydrogenase family
M662_06215	COG3835	regulator
M662_06220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M662_06285	COG3655	Transcriptional regulator
M662_06305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M662_06310	COG1994	Peptidase M50
M662_06325	COG2909	trisaccharide binding
M662_06345	COG0028	Belongs to the TPP enzyme family
M662_06350	COG0440	acetolactate synthase activity
M662_06355	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M662_06360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M662_06365	COG0473	3-isopropylmalate dehydrogenase activity
M662_06370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M662_06375	COG0066	3-isopropylmalate dehydratase activity
M662_06380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M662_06385	COG2267	carboxylic ester hydrolase activity
M662_06390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_06395	COG4605	iron ion homeostasis
M662_06400	COG4604	ABC transporter, ATP-binding protein
M662_06405	COG4607	ABC-type enterochelin transport system periplasmic component
M662_06410	COG0789	Transcriptional regulator
M662_06410	COG4978	Transcriptional regulator
M662_06430	COG2084	Dehydrogenase
M662_06455	COG1063	alcohol dehydrogenase
M662_06470	COG3773	Cell wall hydrolase
M662_06495	COG1253	flavin adenine dinucleotide binding
M662_06500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M662_06505	COG0586	Pfam SNARE associated Golgi protein
M662_06510	COG1968	undecaprenyl-diphosphatase activity
M662_06535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M662_06560	COG0456	acetyltransferase
M662_06575	COG0640	Transcriptional regulator
M662_06605	COG4264	IucA IucC family
M662_06610	COG0019	diaminopimelate decarboxylase activity
M662_06615	COG0789	Transcriptional regulator
M662_06630	COG2153	protein acetylation
M662_06635	COG2226	methyltransferase
M662_06710	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
M662_06725	COG0456	acetyltransferase
M662_06735	COG2258	MOSC domain
M662_06740	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M662_06745	COG1028	Short-chain dehydrogenase reductase Sdr
M662_06750	COG1070	Carbohydrate kinase
M662_06755	COG0277	FAD linked oxidase domain protein
M662_06785	COG3973	AAA domain
M662_06790	COG0693	protein deglycase activity
M662_06850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M662_06865	COG2259	Doxx family
M662_06885	COG4326	sporulation control protein
M662_06890	COG1136	(ABC) transporter
M662_06890	COG0577	efflux transmembrane transporter activity
M662_06915	COG0237	dephospho-CoA kinase activity
M662_06920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M662_06955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M662_06960	COG0432	Pfam Uncharacterised protein family UPF0047
M662_06965	COG2391	methyltransferase activity
M662_06975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M662_06985	COG1231	oxidoreductase activity
M662_07005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M662_07025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M662_07035	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M662_07055	COG0535	radical SAM domain protein
M662_07065	COG2027	D-alanyl-D-alanine carboxypeptidase
M662_07070	COG1301	dicarboxylic acid transport
M662_07090	COG1028	Short-chain dehydrogenase reductase Sdr
M662_07100	COG3859	Proton-coupled thiamine transporter YuaJ
M662_07125	COG0697	spore germination
M662_07145	COG1733	regulation of RNA biosynthetic process
M662_07150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M662_07155	COG0431	NADPH-dependent FMN reductase
M662_07165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M662_07170	COG0640	Transcriptional regulator
M662_07175	COG2814	Major facilitator Superfamily
M662_07180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M662_07185	COG3383	formate dehydrogenase (NAD+) activity
M662_07190	COG2427	Protein of unknown function (DUF1641)
M662_07200	COG0667	Aldo Keto reductase
M662_07220	COG0346	lactoylglutathione lyase activity
M662_07225	COG1714	RDD family
M662_07230	COG2362	D-Aminopeptidase
M662_07235	COG0601	transmembrane transport
M662_07240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M662_07245	COG0444	Belongs to the ABC transporter superfamily
M662_07250	COG4166	transmembrane transport
M662_07255	COG4948	Mandelate Racemase Muconate Lactonizing
M662_07260	COG0791	NLP P60 protein
M662_07265	COG4608	Belongs to the ABC transporter superfamily
M662_07275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M662_07350	COG1595	DNA-templated transcription, initiation
M662_07400	COG3279	Response regulator of the LytR AlgR family
M662_07415	COG0515	serine threonine protein kinase
M662_07440	COG1619	proteins homologs of microcin C7 resistance protein MccF
M662_07455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M662_07455	COG0456	acetyltransferase
M662_07470	COG1619	proteins homologs of microcin C7 resistance protein MccF
M662_07490	COG1028	Short-chain dehydrogenase reductase Sdr
M662_07500	COG0300	oxidoreductase activity
M662_07505	COG0789	Transcriptional regulator
M662_07520	COG1028	Short-chain dehydrogenase reductase Sdr
M662_07525	COG2207	Transcriptional regulator
M662_07535	COG1653	transport
M662_07540	COG1175	transmembrane transport
M662_07545	COG0395	ABC-type sugar transport system, permease component
M662_07550	COG1621	beta-fructofuranosidase activity
M662_07555	COG5578	integral membrane protein
M662_07560	COG1621	beta-fructofuranosidase activity
M662_07615	COG1164	Oligoendopeptidase f
M662_07660	COG1078	dGTPase activity
M662_07710	COG3711	transcriptional antiterminator
M662_07715	COG2190	(PTS) system
M662_07715	COG1263	PTS System
M662_07715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M662_07720	COG2723	6-phospho-beta-galactosidase activity
M662_07725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M662_07725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M662_07730	COG0450	alkyl hydroperoxide reductase
M662_07745	COG4975	Glucose uptake
M662_07750	COG1028	Short-chain dehydrogenase reductase Sdr
M662_07755	COG1620	l-lactate permease
M662_07760	COG2186	Transcriptional regulator
M662_07765	COG0247	lactate metabolic process
M662_07770	COG1139	Iron-sulfur cluster binding protein
M662_07775	COG1556	Lactate utilization protein
M662_07780	COG0346	lactoylglutathione lyase activity
M662_07830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M662_07860	COG1609	Transcriptional regulator
M662_07865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M662_07870	COG1869	D-ribose catabolic process
M662_07875	COG1129	ABC transporter
M662_07880	COG1172	Belongs to the binding-protein-dependent transport system permease family
M662_07885	COG1879	ABC-type sugar transport system periplasmic component
M662_07895	COG1522	sequence-specific DNA binding
M662_07905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M662_07915	COG0778	Nitroreductase
M662_07975	COG0174	glutamine synthetase
M662_07985	COG1227	inorganic diphosphatase activity
M662_08005	COG0583	DNA-binding transcription factor activity
M662_08010	COG2828	Protein conserved in bacteria
M662_08020	COG0598	Magnesium transport protein CorA
M662_08030	COG0492	ferredoxin-NADP+ reductase activity
M662_08035	COG0477	Major facilitator Superfamily
M662_08050	COG1418	mRNA catabolic process
M662_08065	COG0303	'Molybdopterin
M662_08070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M662_08080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M662_08105	COG1562	ergosterol biosynthetic process
M662_08110	COG1131	(ABC) transporter
M662_08140	COG1215	transferase activity, transferring glycosyl groups
M662_08180	COG0436	Aminotransferase
M662_08205	COG0835	chemotaxis
M662_08205	COG0784	Response regulator, receiver
M662_08220	COG1408	metallophosphoesterase
M662_08225	COG1028	Short-chain dehydrogenase reductase Sdr
M662_08230	COG1272	protein, Hemolysin III
M662_08235	COG0517	IMP dehydrogenase activity
M662_08240	COG0477	Major facilitator Superfamily
M662_08245	COG2171	N-acyltransferase activity
M662_08250	COG1473	amidohydrolase
M662_08255	COG1253	flavin adenine dinucleotide binding
M662_08260	COG0668	transmembrane transport
M662_08265	COG1132	(ABC) transporter
M662_08270	COG1132	(ABC) transporter
M662_08275	COG1271	oxidase subunit
M662_08280	COG1294	oxidase, subunit
M662_08285	COG0569	domain protein
M662_08325	COG0028	Belongs to the TPP enzyme family
M662_08330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M662_08340	COG0561	phosphatase activity
M662_08345	COG0242	peptide deformylase activity
M662_08360	COG0022	dehydrogenase e1 component
M662_08365	COG0508	dehydrogenase complex catalyzes the overall conversion of
M662_08395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M662_08415	COG1982	Orn Lys Arg decarboxylase major
M662_08425	COG4476	Belongs to the UPF0223 family
M662_08430	COG4493	Belongs to the UPF0637 family
M662_08440	COG0483	inositol monophosphate 1-phosphatase activity
M662_08455	COG4896	Protein conserved in bacteria
M662_08470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M662_08475	COG2066	Belongs to the glutaminase family
M662_08480	COG4838	Belongs to the UPF0358 family
M662_08485	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M662_08500	COG1845	cytochrome c oxidase, subunit III
M662_08510	COG3336	cytochrome c oxidase
M662_08535	COG0517	IMP dehydrogenase activity
M662_08545	COG2340	Cysteine-rich secretory protein family
M662_08555	COG3679	Belongs to the UPF0342 family
M662_08565	COG4471	UPF0298 protein
M662_08580	COG0742	ribosomal rna small subunit methyltransferase
M662_08585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M662_08590	COG3314	Sporulation integral membrane protein YlbJ
M662_08595	COG1752	Esterase of the alpha-beta hydrolase superfamily
M662_08600	COG3480	Lon protease (S16) C-terminal proteolytic domain
M662_08605	COG1323	Belongs to the UPF0348 family
M662_08610	COG1399	metal-binding, possibly nucleic acid-binding protein
M662_08615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M662_08620	COG1024	Enoyl-CoA hydratase
M662_08630	COG0454	-acetyltransferase
M662_08635	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M662_08645	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M662_08650	COG2001	Belongs to the MraZ family
M662_08655	COG0275	rRNA processing
M662_08660	COG4839	cell division protein FtsL
M662_08670	COG0768	penicillin binding
M662_08675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M662_08680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M662_08685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M662_08690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M662_08695	COG0772	Belongs to the SEDS family
M662_08700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M662_08705	COG0849	cell division
M662_08710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M662_08720	COG1191	sigma factor activity
M662_08725	COG1191	sigma factor activity
M662_08730	COG1873	PFAM PRC-barrel domain
M662_08740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M662_08745	COG1799	cell septum assembly
M662_08750	COG0762	integral membrane protein
M662_08755	COG2302	S4 RNA-binding domain
M662_08760	COG3599	regulation of cell shape
M662_08765	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M662_08770	COG0564	pseudouridine synthase activity
M662_08780	COG2233	PERMEase
M662_08785	COG0540	Belongs to the ATCase OTCase family
M662_08790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M662_08795	COG0505	Belongs to the CarA family
M662_08800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M662_08805	COG0543	2 iron, 2 sulfur cluster binding
M662_08815	COG0284	orotidine-5'-phosphate decarboxylase activity
M662_08820	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M662_08835	COG2304	oxidoreductase activity
M662_08845	COG1561	YicC-like family, N-terminal region
M662_08850	COG2052	Domain of unknown function (DUF370)
M662_08855	COG0194	GDP metabolic process
M662_08860	COG1758	RNA polymerase activity
M662_08865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M662_08870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M662_08875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M662_08880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M662_08880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M662_08885	COG0631	protein serine/threonine phosphatase activity
M662_08890	COG0515	serine threonine protein kinase
M662_08890	COG2815	serine threonine protein kinase
M662_08895	COG1162	GTPase activity
M662_08900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M662_08905	COG1564	THIamine pyrophosphokinase
M662_08915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M662_08920	COG1302	Protein conserved in bacteria
M662_08925	COG1461	Dihydroxyacetone kinase
M662_08930	COG0730	response to heat
M662_08935	COG0175	sulfate reduction
M662_08940	COG2046	Belongs to the sulfate adenylyltransferase family
M662_08945	COG0529	Catalyzes the synthesis of activated sulfate
M662_08970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M662_08995	COG1760	l-serine dehydratase
M662_09000	COG1760	l-serine dehydratase
M662_09005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M662_09015	COG0416	fatty acid biosynthetic process
M662_09020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M662_09025	COG1028	Short-chain dehydrogenase reductase Sdr
M662_09030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M662_09035	COG0571	ribonuclease III activity
M662_09040	COG4840	Belongs to the UPF0435 family
M662_09045	COG1196	nuclear chromosome segregation
M662_09050	COG0552	protein localization to endoplasmic reticulum
M662_09055	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M662_09060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M662_09065	COG0228	four-way junction DNA binding
M662_09070	COG1837	Belongs to the UPF0109 family
M662_09080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M662_09085	COG0336	Belongs to the RNA methyltransferase TrmD family
M662_09090	COG0335	large ribosomal subunit rRNA binding
M662_09100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M662_09105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M662_09120	COG0045	succinate-CoA ligase (ADP-forming) activity
M662_09125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M662_09130	COG0758	DNA mediated transformation
M662_09135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M662_09140	COG4974	Belongs to the 'phage' integrase family
M662_09145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M662_09150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M662_09155	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M662_09165	COG1815	bacterial-type flagellum-dependent cell motility
M662_09170	COG1558	bacterial-type flagellum-dependent cell motility
M662_09175	COG1677	Flagellar hook-basal body complex protein FliE
M662_09180	COG1766	The M ring may be actively involved in energy transduction
M662_09185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M662_09195	COG1157	protein secretion by the type III secretion system
M662_09215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M662_09225	COG4786	Flagellar basal body rod
M662_09230	COG1582	Flagellar protein (FlbD)
M662_09240	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M662_09245	COG1776	CheC inhibitor of MCP methylation
M662_09245	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M662_09250	COG2201	protein-glutamate methylesterase activity
M662_09255	COG3190	flagellar
M662_09260	COG1338	Plays a role in the flagellum-specific transport system
M662_09265	COG1987	bacterial-type flagellum assembly
M662_09270	COG1684	flagellar biosynthetic protein fliR
M662_09275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M662_09280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M662_09285	COG1419	protein localization to endoplasmic reticulum
M662_09290	COG0455	bacterial-type flagellum organization
M662_09295	COG2201	protein-glutamate methylesterase activity
M662_09300	COG0643	Histidine kinase
M662_09300	COG2198	Histidine kinase
M662_09305	COG0835	chemotaxis
M662_09310	COG1776	CheC inhibitor of MCP methylation
M662_09315	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M662_09320	COG1191	sigma factor activity
M662_09330	COG0052	Belongs to the universal ribosomal protein uS2 family
M662_09335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M662_09340	COG0528	UMP kinase activity
M662_09345	COG0233	cytoplasmic translational termination
M662_09350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M662_09355	COG4589	Belongs to the CDS family
M662_09360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M662_09365	COG0750	zinc metalloprotease
M662_09370	COG0442	prolyl-tRNA aminoacylation
M662_09375	COG2176	DNA-directed DNA polymerase activity
M662_09380	COG0779	Required for maturation of 30S ribosomal subunits
M662_09385	COG0195	Participates in both transcription termination and antitermination
M662_09390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M662_09400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M662_09405	COG1550	Protein conserved in bacteria
M662_09410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M662_09415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M662_09420	COG0196	riboflavin kinase activity
M662_09425	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M662_09430	COG1185	polyribonucleotide nucleotidyltransferase activity
M662_09435	COG0726	polysaccharide deacetylase
M662_09445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M662_09450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M662_09455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M662_09460	COG0527	aspartate kinase activity
M662_09465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M662_09470	COG0740	serine-type endopeptidase activity
M662_09480	COG1674	ftsk spoiiie
M662_09485	COG2188	Transcriptional regulator
M662_09510	COG0612	Peptidase, M16
M662_09515	COG0612	Peptidase, M16
M662_09520	COG0300	oxidoreductase activity
M662_09535	COG1426	Protein conserved in bacteria
M662_09540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M662_09545	COG1058	Belongs to the CinA family
M662_09545	COG1546	Belongs to the CinA family
M662_09550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M662_09555	COG1418	mRNA catabolic process
M662_09560	COG1692	metallophosphoesterase
M662_09565	COG2359	stage V sporulation protein S
M662_09570	COG1063	alcohol dehydrogenase
M662_09575	COG0156	8-amino-7-oxononanoate synthase activity
M662_09580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M662_09585	COG4550	Control of competence regulator ComK, YlbF/YmcA
M662_09595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M662_09600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M662_09605	COG3620	sequence-specific DNA binding
M662_09610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M662_09615	COG1923	regulation of RNA biosynthetic process
M662_09620	COG0464	growth
M662_09625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M662_09630	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M662_09635	COG0789	Transcriptional regulator
M662_09640	COG0174	glutamine synthetase
M662_09665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M662_09670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M662_09675	COG4224	UPF0291 protein
M662_09680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M662_09690	COG3763	UPF0154 protein
M662_09695	COG0785	Cytochrome C biogenesis protein
M662_09700	COG2111	Na H antiporter
M662_09705	COG4846	Membrane protein involved in cytochrome C biogenesis
M662_09715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M662_09720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M662_09735	COG0464	growth
M662_09740	COG0824	Thioesterase
M662_09755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M662_09760	COG1469	GTP cyclohydrolase I activity
M662_09765	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M662_09775	COG1174	glycine betaine transport
M662_09780	COG1832	CoA-binding protein
M662_09785	COG0187	DNA topoisomerase II activity
M662_09790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M662_09800	COG1960	acyl-CoA dehydrogenase activity
M662_09805	COG0318	PFAM AMP-dependent synthetase and ligase
M662_09810	COG0439	Biotin carboxylase
M662_09815	COG0511	ligase activity, forming carbon-carbon bonds
M662_09820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M662_09825	COG1024	Enoyl-CoA hydratase
M662_09830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M662_09835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M662_09840	COG2268	Band 7 protein
M662_09850	COG0438	transferase activity, transferring glycosyl groups
M662_09865	COG0778	Nitroreductase
M662_09870	COG2996	Protein conserved in bacteria
M662_09880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M662_09890	COG0604	alcohol dehydrogenase
M662_09895	COG3584	3D domain protein
M662_09895	COG1388	LysM domain
M662_09900	COG0488	(ABC) transporter
M662_09915	COG2032	superoxide dismutase activity
M662_09920	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M662_09935	COG2105	PFAM AIG2 family protein
M662_09935	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M662_09940	COG3191	aminopeptidase activity
M662_09945	COG1254	Belongs to the acylphosphatase family
M662_09950	COG4221	oxidoreductase activity
M662_09970	COG0400	carboxylic ester hydrolase activity
M662_09975	COG3180	Ammonia monooxygenase
M662_09980	COG0456	acetyltransferase
M662_09990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M662_09990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M662_10000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M662_10005	COG0419	ATPase involved in DNA repair
M662_10010	COG0420	3'-5' exonuclease activity
M662_10015	COG4479	Belongs to the UPF0346 family
M662_10020	COG0805	protein transport
M662_10025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M662_10030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M662_10035	COG0746	molybdenum cofactor guanylyltransferase activity
M662_10040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M662_10050	COG1418	mRNA catabolic process
M662_10055	COG1801	Protein of unknown function DUF72
M662_10070	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M662_10075	COG0328	RNA-DNA hybrid ribonuclease activity
M662_10085	COG1755	Isoprenylcysteine carboxyl methyltransferase
M662_10090	COG3424	synthase
M662_10100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M662_10105	COG0116	Belongs to the methyltransferase superfamily
M662_10115	COG3599	regulation of cell shape
M662_10120	COG4474	Belongs to the UPF0398 family
M662_10130	COG0295	cytidine deaminase activity
M662_10135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M662_10150	COG3331	DNA recombination
M662_10155	COG4499	WXG100 protein secretion system (Wss), protein YukC
M662_10155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M662_10160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M662_10165	COG3935	DnaD domain protein
M662_10170	COG0017	Asparaginyl-tRNA synthetase
M662_10175	COG0436	Aminotransferase
M662_10190	COG1199	ATP-dependent helicase activity
M662_10190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M662_10195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M662_10200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M662_10210	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M662_10210	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M662_10220	COG0438	transferase activity, transferring glycosyl groups
M662_10225	COG1803	Methylglyoxal synthase
M662_10230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M662_10235	COG1694	Mazg nucleotide pyrophosphohydrolase
M662_10240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M662_10245	COG2738	Putative neutral zinc metallopeptidase
M662_10255	COG4347	Protein of unknown function (DUF1405)
M662_10260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M662_10260	COG2010	Cytochrome c
M662_10265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M662_10270	COG0723	plastoquinol--plastocyanin reductase activity
M662_10280	COG5582	Belongs to the UPF0302 family
M662_10285	COG0457	Tetratricopeptide repeat
M662_10295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M662_10300	COG0287	Prephenate dehydrogenase
M662_10305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M662_10310	COG4401	Chorismate mutase type I
M662_10315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M662_10320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M662_10325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M662_10330	COG0105	UTP biosynthetic process
M662_10335	COG0142	geranyltranstransferase activity
M662_10340	COG2226	methyltransferase
M662_10345	COG0142	geranyltranstransferase activity
M662_10355	COG0776	regulation of translation
M662_10360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M662_10380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M662_10385	COG1160	GTP binding
M662_10405	COG1304	FMN binding
M662_10410	COG0539	negative regulation of cytoplasmic translation
M662_10415	COG0204	Acyl-transferase
M662_10425	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M662_10430	COG2959	enzyme of heme biosynthesis
M662_10435	COG3773	Cell wall hydrolase
M662_10435	COG3409	Peptidoglycan-binding domain 1 protein
M662_10440	COG2339	peptidase activity
M662_10445	COG0252	asparaginase activity
M662_10450	COG0492	ferredoxin-NADP+ reductase activity
M662_10455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M662_10460	COG1181	Belongs to the D-alanine--D-alanine ligase family
M662_10465	COG4862	establishment of competence for transformation
M662_10470	COG0789	Transcriptional regulator
M662_10475	COG1408	metallophosphoesterase
M662_10490	COG3546	catalase activity
M662_10500	COG1266	CAAX protease self-immunity
M662_10505	COG0514	ATP-dependent DNA helicase (RecQ)
M662_10510	COG4955	Helix-turn-helix domain
M662_10515	COG1141	Ferredoxin
M662_10530	COG1595	DNA-templated transcription, initiation
M662_10545	COG5002	protein histidine kinase activity
M662_10550	COG0745	RESPONSE REGULATOR receiver
M662_10555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M662_10560	COG1333	cytochrome c biogenesis protein
M662_10565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M662_10570	COG1187	pseudouridine synthase activity
M662_10575	COG0700	Nucleoside recognition
M662_10580	COG2715	membrane protein required for spore maturation
M662_10585	COG1686	Belongs to the peptidase S11 family
M662_10590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M662_10595	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M662_10600	COG1547	Domain of unknown function (DUF309)
M662_10605	COG0456	acetyltransferase
M662_10615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M662_10620	COG0019	diaminopimelate decarboxylase activity
M662_10625	COG0697	spore germination
M662_10635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M662_10670	COG1686	Belongs to the peptidase S11 family
M662_10685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M662_10690	COG4974	Belongs to the 'phage' integrase family
M662_10700	COG0735	belongs to the Fur family
M662_10705	COG1300	Membrane
M662_10710	COG1379	DNA repair
M662_10715	COG0494	nUDIX hydrolase
M662_10720	COG0667	Aldo Keto reductase
M662_10735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M662_10740	COG4821	SIS domain
M662_10745	COG2188	Transcriptional regulator
M662_10750	COG0363	glucosamine-6-phosphate deaminase activity
M662_10755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M662_10760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M662_10760	COG1263	PTS System
M662_10760	COG2190	(PTS) system
M662_10765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M662_10790	COG0300	oxidoreductase activity
M662_10805	COG0456	acetyltransferase
M662_10810	COG2200	EAL domain
M662_10830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M662_10845	COG0800	Aldolase
M662_10855	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M662_10860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M662_10865	COG1609	Transcriptional regulator
M662_10870	COG2322	membrane
M662_10885	COG0456	acetyltransferase
M662_10900	COG4721	ABC-type cobalt transport system, permease component
M662_10905	COG1122	ATPase activity
M662_10910	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M662_10925	COG0523	cobalamin synthesis protein
M662_10935	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M662_10940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M662_10950	COG0772	Belongs to the SEDS family
M662_10955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M662_10965	COG2755	lipolytic protein G-D-S-L family
M662_10985	COG1012	belongs to the aldehyde dehydrogenase family
M662_10990	COG0028	Belongs to the TPP enzyme family
M662_10995	COG0436	Aminotransferase
M662_11000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M662_11005	COG1960	acyl-CoA dehydrogenase activity
M662_11010	COG4294	response to UV
M662_11035	COG2323	membrane
M662_11045	COG0516	GMP reductase activity
M662_11050	COG3706	GGDEF domain
M662_11105	COG0492	ferredoxin-NADP+ reductase activity
M662_11110	COG0488	(ABC) transporter
M662_11115	COG0778	Nitroreductase
M662_11120	COG0367	asparagine synthase
M662_11135	COG0861	Integral membrane protein TerC family
M662_11150	COG0395	ABC-type sugar transport system, permease component
M662_11155	COG1175	transmembrane transport
M662_11170	COG1368	sulfuric ester hydrolase activity
M662_11175	COG2070	2-Nitropropane dioxygenase
M662_11190	COG2207	Transcriptional regulator
M662_11190	COG3708	Transcriptional regulator
M662_11195	COG0109	protoheme IX farnesyltransferase activity
M662_11220	COG2814	Major facilitator Superfamily
M662_11225	COG2514	catechol 2,3-dioxygenase activity
M662_11230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M662_11235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M662_11240	COG2022	thiamine diphosphate biosynthetic process
M662_11250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M662_11255	COG0352	thiamine-phosphate diphosphorylase activity
M662_11260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M662_11265	COG4145	pantothenate transmembrane transporter activity
M662_11275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M662_11285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M662_11290	COG0246	Mannitol dehydrogenase
M662_11295	COG3711	transcriptional antiterminator
M662_11300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M662_11300	COG2213	PTS system mannitol-specific
M662_11305	COG3493	citrate carrier protein
M662_11310	COG4565	transcriptional regulatory protein
M662_11315	COG3290	protein histidine kinase activity
M662_11335	COG0004	ammonium transporteR
M662_11340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M662_11355	COG0551	DNA topoisomerase type I activity
M662_11355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M662_11375	COG2226	methyltransferase
M662_11385	COG2252	PERMEase
M662_11400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M662_11420	COG5002	protein histidine kinase activity
M662_11420	COG3850	Histidine kinase
M662_11425	COG0745	RESPONSE REGULATOR receiver
M662_11430	COG0300	oxidoreductase activity
M662_11435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M662_11440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M662_11445	COG4187	Peptidase family M20/M25/M40
M662_11450	COG0584	glycerophosphoryl diester phosphodiesterase
M662_11455	COG1902	pentaerythritol trinitrate reductase activity
M662_11460	COG1234	tRNA 3'-trailer cleavage
M662_11465	COG1012	belongs to the aldehyde dehydrogenase family
M662_11475	COG1136	(ABC) transporter
M662_11495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M662_11500	COG2195	Cleaves the N-terminal amino acid of tripeptides
M662_11505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M662_11510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M662_11515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M662_11515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M662_11525	COG1376	ErfK ybiS ycfS ynhG family protein
M662_11530	COG4129	membrane
M662_11540	COG0508	dehydrogenase complex catalyzes the overall conversion of
M662_11545	COG0022	dehydrogenase e1 component
M662_11550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M662_11555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M662_11570	COG0280	phosphate acetyltransferase
M662_11575	COG3290	protein histidine kinase activity
M662_11575	COG3829	transcription factor binding
M662_11590	COG2176	DNA-directed DNA polymerase activity
M662_11595	COG0527	aspartate kinase activity
M662_11605	COG0745	RESPONSE REGULATOR receiver
M662_11610	COG0750	zinc metalloprotease
M662_11615	COG0497	DNA recombination
M662_11620	COG1438	arginine binding
M662_11625	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M662_11640	COG0142	geranyltranstransferase activity
M662_11645	COG1722	exodeoxyribonuclease VII activity
M662_11650	COG1570	exodeoxyribonuclease VII activity
M662_11660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M662_11665	COG1302	Protein conserved in bacteria
M662_11670	COG0439	Biotin carboxylase
M662_11675	COG0511	ligase activity, forming carbon-carbon bonds
M662_11715	COG3854	ATPases associated with a variety of cellular activities
M662_11720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M662_11725	COG0006	proline dipeptidase activity
M662_11730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M662_11745	COG1752	Esterase of the alpha-beta hydrolase superfamily
M662_11750	COG1321	iron dependent repressor
M662_11755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M662_11760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M662_11765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M662_11770	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M662_11775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M662_11780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M662_11795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M662_11800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M662_11810	COG4537	Required for transformation and DNA binding
M662_11830	COG1393	Belongs to the ArsC family
M662_11840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M662_11850	COG0390	transport system, permease component
M662_11855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M662_11860	COG1368	sulfuric ester hydrolase activity
M662_11865	COG1940	carbohydrate kinase activity
M662_11875	COG0697	spore germination
M662_11885	COG0705	Rhomboid family
M662_11885	COG0457	Tetratricopeptide repeat
M662_11895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M662_11900	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M662_11910	COG0704	Plays a role in the regulation of phosphate uptake
M662_11920	COG0581	inorganic phosphate transmembrane transporter activity
M662_11925	COG0573	inorganic phosphate transmembrane transporter activity
M662_11930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M662_11940	COG0477	Major facilitator Superfamily
M662_11975	COG1283	sodium-dependent phosphate transmembrane transporter activity
M662_11980	COG0840	transmembrane signaling receptor activity
M662_11990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M662_12005	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M662_12015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M662_12020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M662_12025	COG2384	SAM-dependent methyltransferase
M662_12040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M662_12045	COG0358	DNA primase activity
M662_12050	COG1671	Belongs to the UPF0178 family
M662_12055	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M662_12060	COG0517	IMP dehydrogenase activity
M662_12065	COG0751	glycine-tRNA ligase activity
M662_12070	COG0752	glycyl-tRNA synthetase alpha subunit
M662_12075	COG1381	Involved in DNA repair and RecF pathway recombination
M662_12085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M662_12090	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M662_12095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M662_12100	COG1480	7TM receptor with intracellular HD hydrolase
M662_12105	COG1702	phosphate starvation-inducible protein PhoH
M662_12125	COG4864	UPF0365 protein
M662_12130	COG1030	water channel activity
M662_12135	COG1610	YqeY-like protein
M662_12140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M662_12145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M662_12150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M662_12155	COG2264	protein methyltransferase activity
M662_12160	COG0484	heat shock protein binding
M662_12165	COG0443	Heat shock 70 kDa protein
M662_12170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M662_12175	COG1420	regulation of RNA biosynthetic process
M662_12180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M662_12185	COG0481	GTPase activity
M662_12195	COG0860	N-Acetylmuramoyl-L-alanine amidase
M662_12200	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M662_12205	COG0268	Binds directly to 16S ribosomal RNA
M662_12210	COG1466	dna polymerase III delta subunit
M662_12220	COG2333	competence protein COMEC
M662_12220	COG0658	competence protein
M662_12225	COG2131	deaminase
M662_12230	COG1555	photosystem II stabilization
M662_12230	COG1596	polysaccharide export
M662_12235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M662_12240	COG2226	methyltransferase
M662_12245	COG0799	negative regulation of ribosome biogenesis
M662_12250	COG1713	HD superfamily hydrolase involved in NAD metabolism
M662_12255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M662_12260	COG1534	Rna-binding protein
M662_12265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M662_12270	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M662_12275	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M662_12285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M662_12285	COG2111	Na H antiporter
M662_12290	COG1006	Multisubunit Na H antiporter MnhC subunit
M662_12305	COG2212	antiporter activity
M662_12325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M662_12335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M662_12340	COG0572	uridine kinase
M662_12345	COG4122	O-methyltransferase activity
M662_12350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M662_12355	COG3906	Belongs to the UPF0473 family
M662_12360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M662_12365	COG4472	Bacterial protein of unknown function (DUF965)
M662_12370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M662_12375	COG0628	permease
M662_12385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M662_12395	COG0482	sulfurtransferase activity
M662_12400	COG1104	cysteine desulfurase activity
M662_12405	COG1959	2 iron, 2 sulfur cluster binding
M662_12410	COG2364	Membrane
M662_12415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M662_12430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M662_12435	COG0124	histidyl-tRNA synthetase
M662_12440	COG4991	sh3 domain protein
M662_12440	COG0860	N-Acetylmuramoyl-L-alanine amidase
M662_12440	COG3103	Sh3 type 3 domain protein
M662_12445	COG1490	D-aminoacyl-tRNA deacylase activity
M662_12450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M662_12455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M662_12460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M662_12460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M662_12465	COG5416	Lipopolysaccharide assembly protein A domain
M662_12470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M662_12470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M662_12480	COG2244	polysaccharide biosynthetic process
M662_12485	COG2323	membrane
M662_12490	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M662_12500	COG1862	Preprotein translocase
M662_12505	COG0343	queuine tRNA-ribosyltransferase activity
M662_12510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M662_12520	COG2255	four-way junction helicase activity
M662_12525	COG0632	four-way junction helicase activity
M662_12535	COG0217	transcriptional regulatory protein
M662_12545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M662_12560	COG0077	Prephenate dehydratase
M662_12565	COG4492	Belongs to the UPF0735 family
M662_12570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M662_12575	COG3290	protein histidine kinase activity
M662_12585	COG2868	ribosomal protein
M662_12590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M662_12595	COG1530	ribonuclease E activity
M662_12600	COG1994	Peptidase M50
M662_12610	COG2894	cell division
M662_12615	COG0850	regulation of cytokinetic process
M662_12625	COG1792	Involved in formation and maintenance of cell shape
M662_12630	COG1077	Cell shape determining protein MreB Mrl
M662_12635	COG2003	Belongs to the UPF0758 family
M662_12665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M662_12675	COG1459	type II secretion system
M662_12685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M662_12695	COG0285	dihydrofolate synthase activity
M662_12700	COG0525	valine-tRNA ligase activity
M662_12705	COG1388	LysM domain
M662_12710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M662_12715	COG0113	porphobilinogen synthase activity
M662_12720	COG1587	Uroporphyrinogen-III synthase
M662_12725	COG0181	hydroxymethylbilane synthase activity
M662_12730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M662_12735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M662_12745	COG1126	abc transporter atp-binding protein
M662_12755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M662_12760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M662_12765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M662_12770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M662_12775	COG0544	peptidyl-prolyl cis-trans isomerase activity
M662_12780	COG0457	Tetratricopeptide repeat
M662_12780	COG1477	protein flavinylation
M662_12795	COG3011	Protein conserved in bacteria
M662_12865	COG0582	viral genome integration into host DNA
M662_12875	COG0758	DNA mediated transformation
M662_12890	COG0622	Phosphoesterase
M662_12895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M662_12900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M662_12905	COG5401	PFAM Sporulation and spore germination
M662_12910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M662_12915	COG1846	Transcriptional regulator
M662_12920	COG2197	response regulator
M662_12925	COG2197	response regulator
M662_12930	COG4585	Histidine kinase
M662_12935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M662_12940	COG1053	succinate dehydrogenase
M662_12945	COG2009	succinate dehydrogenase
M662_12955	COG0322	excinuclease ABC activity
M662_12960	COG3118	belongs to the thioredoxin family
M662_12965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M662_12970	COG2086	electron transfer activity
M662_12975	COG1024	Enoyl-CoA hydratase
M662_12980	COG1309	transcriptional regulator
M662_12985	COG0318	PFAM AMP-dependent synthetase and ligase
M662_12990	COG3766	membrane
M662_12995	COG1193	negative regulation of DNA recombination
M662_13000	COG1796	DNA polymerase
M662_13000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M662_13005	COG1286	toxin biosynthetic process
M662_13010	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M662_13015	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M662_13020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M662_13020	COG0072	phenylalanine-tRNA ligase activity
M662_13025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M662_13030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M662_13040	COG1363	Peptidase, m42
M662_13055	COG0398	Pfam SNARE associated Golgi protein
M662_13065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M662_13070	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M662_13075	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M662_13080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M662_13090	COG1484	DNA-dependent DNA replication
M662_13095	COG3611	Membrane attachment protein
M662_13100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M662_13110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M662_13115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M662_13135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M662_13135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M662_13150	COG5002	protein histidine kinase activity
M662_13155	COG0745	RESPONSE REGULATOR receiver
M662_13165	COG0039	L-malate dehydrogenase activity
M662_13170	COG0538	isocitrate dehydrogenase activity
M662_13175	COG0372	Belongs to the citrate synthase family
M662_13180	COG0628	permease
M662_13185	COG3030	protein affecting phage T7 exclusion by the F plasmid
M662_13195	COG0205	6-phosphofructokinase activity
M662_13200	COG0825	malonyl-CoA metabolic process
M662_13205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M662_13210	COG2188	Transcriptional regulator
M662_13215	COG0281	malic enzyme
M662_13220	COG0587	DNA-directed DNA polymerase activity
M662_13235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M662_13245	COG4109	DRTGG domain
M662_13250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M662_13265	COG1842	Phage shock protein A
M662_13275	COG0385	Bile acid
M662_13285	COG1028	Short-chain dehydrogenase reductase Sdr
M662_13290	COG0589	response to stress
M662_13295	COG0521	Mo-molybdopterin cofactor biosynthetic process
M662_13305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M662_13310	COG0827	DNA restriction-modification system
M662_13315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M662_13320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M662_13325	COG0301	tRNA thio-modification
M662_13330	COG1104	cysteine desulfurase activity
M662_13340	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M662_13345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M662_13350	COG1309	transcriptional regulator
M662_13355	COG1956	GAF domain-containing protein
M662_13360	COG2199	diguanylate cyclase activity
M662_13360	COG2203	Gaf domain
M662_13365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M662_13370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M662_13375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M662_13380	COG0454	-acetyltransferase
M662_13385	COG0517	IMP dehydrogenase activity
M662_13390	COG0123	including yeast histone deacetylase and acetoin utilization protein
M662_13405	COG1609	Transcriptional regulator
M662_13410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M662_13410	COG1605	Chorismate mutase
M662_13415	COG3118	belongs to the thioredoxin family
M662_13420	COG4980	gas vesicle protein
M662_13430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M662_13440	COG1674	ftsk spoiiie
M662_13445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M662_13450	COG4848	Belongs to the UPF0354 family
M662_13455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M662_13470	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M662_13475	COG1363	Peptidase, m42
M662_13485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M662_13490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M662_13495	COG0510	thiamine kinase activity
M662_13500	COG1597	lipid kinase activity
M662_13505	COG2200	EAL domain
M662_13520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M662_13525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M662_13530	COG1349	DNA-binding transcription factor activity
M662_13535	COG1187	pseudouridine synthase activity
M662_13540	COG2244	polysaccharide biosynthetic process
M662_13545	COG2081	HI0933 family
M662_13575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M662_13580	COG0495	leucyl-tRNA aminoacylation
M662_13585	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M662_13595	COG2267	carboxylic ester hydrolase activity
M662_13600	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M662_13605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M662_13610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M662_13615	COG0494	nUDIX hydrolase
M662_13625	COG4948	Mandelate Racemase Muconate Lactonizing
M662_13630	COG0318	PFAM AMP-dependent synthetase and ligase
M662_13635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M662_13640	COG0596	Alpha beta hydrolase
M662_13645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M662_13650	COG1169	isochorismate synthase
M662_13655	COG1575	Belongs to the MenA family. Type 1 subfamily
M662_13660	COG2050	protein possibly involved in aromatic compounds catabolism
M662_13670	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M662_13730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M662_13740	COG0166	Belongs to the GPI family
M662_13745	COG1979	alcohol dehydrogenase
M662_13750	COG2155	Conserved Protein
M662_13755	COG1098	S1 RNA binding domain
M662_13765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M662_13770	COG2032	superoxide dismutase activity
M662_13785	COG0813	purine-nucleoside phosphorylase activity
M662_13795	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M662_13800	COG3584	3D domain protein
M662_13810	COG1252	NADH dehydrogenase
M662_13815	COG0492	ferredoxin-NADP+ reductase activity
M662_13825	COG0316	Belongs to the HesB IscA family
M662_13830	COG4844	belongs to the
M662_13835	COG4837	Protein of unknown function (DUF1462)
M662_13840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M662_13845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M662_13850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M662_13860	COG0647	UMP catabolic process
M662_13865	COG2445	Protein of unknown function DUF86
M662_13880	COG4470	Protein conserved in bacteria
M662_13890	COG0739	heme binding
M662_13900	COG0733	neurotransmitter:sodium symporter activity
M662_13905	COG1757	Na H antiporter
M662_13915	COG0737	Belongs to the 5'-nucleotidase family
M662_13920	COG0730	response to heat
M662_13925	COG0719	Fe-S assembly protein
M662_13930	COG0822	iron-sulfur transferase activity
M662_13935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M662_13940	COG0719	Fe-S assembly protein
M662_13945	COG0396	ATPase activity
M662_13950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M662_13955	COG1464	Belongs to the NlpA lipoprotein family
M662_13960	COG2011	ABC-type metal ion transport system permease component
M662_13965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M662_13985	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M662_13990	COG0509	glycine decarboxylation via glycine cleavage system
M662_13995	COG1393	Belongs to the ArsC family
M662_14000	COG1960	acyl-CoA dehydrogenase activity
M662_14005	COG0183	Belongs to the thiolase family
M662_14010	COG1250	3-hydroxyacyl-CoA dehydrogenase
M662_14010	COG1024	Enoyl-CoA hydratase
M662_14025	COG5577	PFAM Coat F domain
M662_14030	COG2608	mercury ion transmembrane transporter activity
M662_14065	COG2814	Major facilitator Superfamily
M662_14075	COG2112	serine threonine protein kinase
M662_14085	COG0716	FMN binding
M662_14100	COG2368	4-hydroxyphenylacetate
M662_14105	COG2224	Isocitrate lyase
M662_14110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M662_14120	COG0129	dihydroxy-acid dehydratase activity
M662_14130	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M662_14135	COG3321	synthase
M662_14135	COG0604	alcohol dehydrogenase
M662_14140	COG1733	regulation of RNA biosynthetic process
M662_14150	COG5577	PFAM Coat F domain
M662_14155	COG1280	lysine exporter protein (LysE YggA)
M662_14160	COG3403	YqcI/YcgG family
M662_14165	COG1113	amino acid transport
M662_14180	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M662_14195	COG0557	exoribonuclease II activity
M662_14200	COG1647	Serine aminopeptidase, S33
M662_14205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M662_14210	COG1349	DNA-binding transcription factor activity
M662_14215	COG1105	Belongs to the carbohydrate kinase PfkB family
M662_14220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M662_14220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M662_14220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M662_14225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M662_14230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M662_14240	COG0778	Nitroreductase
M662_14245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M662_14250	COG0148	phosphopyruvate hydratase activity
M662_14260	COG0149	triose-phosphate isomerase activity
M662_14265	COG0126	phosphoglycerate kinase activity
M662_14295	COG0740	serine-type endopeptidase activity
M662_14300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M662_14305	COG1481	regulation of sporulation
M662_14310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M662_14315	COG1660	Displays ATPase and GTPase activities
M662_14320	COG1051	belongs to the nudix hydrolase family
M662_14325	COG0492	ferredoxin-NADP+ reductase activity
M662_14335	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M662_14335	COG0140	phosphoribosyl-ATP diphosphatase activity
M662_14345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M662_14350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M662_14355	COG0131	Imidazoleglycerol-phosphate dehydratase
M662_14360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M662_14365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M662_14370	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M662_14380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M662_14385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M662_14390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M662_14395	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M662_14400	COG0110	maltose O-acetyltransferase activity
M662_14405	COG0546	phosphoglycolate phosphatase activity
M662_14410	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M662_14415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M662_14420	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M662_14425	COG1950	PFAM Membrane protein of
M662_14430	COG3595	metallopeptidase activity
M662_14435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M662_14440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M662_14445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M662_14450	COG0556	nucleotide-excision repair
M662_14455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M662_14460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M662_14465	COG1612	heme a metabolic process
M662_14470	COG1120	ATPase activity
M662_14475	COG2059	Chromate
M662_14480	COG2059	Chromate
M662_14490	COG2351	hydroxyisourate hydrolase activity
M662_14500	COG2508	Transcriptional regulator
M662_14505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M662_14510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M662_14515	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M662_14525	COG0154	amidase activity
M662_14530	COG2080	2 iron, 2 sulfur cluster binding
M662_14535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M662_14545	COG2068	MobA-Related Protein
M662_14550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M662_14555	COG0402	S-adenosylhomocysteine deaminase activity
M662_14560	COG1288	antiporter activity
M662_14610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M662_14615	COG0793	Belongs to the peptidase S41A family
M662_14615	COG3409	Peptidoglycan-binding domain 1 protein
M662_14620	COG2884	Cell division ATP-binding protein ftsE
M662_14630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M662_14635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M662_14645	COG0653	protein targeting
M662_14675	COG1516	flagellar protein fliS
M662_14680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M662_14685	COG1334	flagellar protein FlaG
M662_14690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M662_14695	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M662_14705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M662_14710	COG4786	Flagellar basal body rod
M662_14710	COG1256	bacterial-type flagellum assembly
M662_14715	COG3418	PFAM FlgN family protein
M662_14730	COG1040	competence protein
M662_14735	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M662_14740	COG1307	EDD domain protein, DegV family
M662_14745	COG2197	response regulator
M662_14750	COG4585	Histidine kinase
M662_14755	COG1739	Uncharacterized protein family UPF0029
M662_14760	COG1316	TRANSCRIPTIONal
M662_14765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M662_14775	COG1316	TRANSCRIPTIONal
M662_14785	COG4873	Protein conserved in bacteria
M662_14810	COG3012	SEC-C Motif Domain Protein
M662_14810	COG1405	negative regulation of cell septum assembly
M662_14815	COG0577	efflux transmembrane transporter activity
M662_14820	COG1136	(ABC) transporter
M662_14825	COG0662	Cupin 2, conserved barrel domain protein
M662_14830	COG0534	Mate efflux family protein
M662_14835	COG0840	transmembrane signaling receptor activity
M662_14840	COG0003	Pfam Anion-transporting ATPase
M662_14850	COG1966	Carbon starvation protein
M662_14865	COG1126	abc transporter atp-binding protein
M662_14870	COG0765	amino acid transport
M662_14875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M662_14880	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_14895	COG5002	protein histidine kinase activity
M662_14895	COG3850	Histidine kinase
M662_14900	COG0745	RESPONSE REGULATOR receiver
M662_14905	COG0247	lactate metabolic process
M662_14910	COG0277	FAD linked oxidase domain protein
M662_14915	COG1737	Transcriptional regulator
M662_14920	COG0395	ABC-type sugar transport system, permease component
M662_14925	COG1175	transmembrane transport
M662_14940	COG2971	BadF BadG BcrA BcrD
M662_14945	COG3949	Membrane
M662_14950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M662_14950	COG2508	Transcriptional regulator
M662_14955	COG0686	Belongs to the AlaDH PNT family
M662_14965	COG1028	Short-chain dehydrogenase reductase Sdr
M662_14980	COG2358	TRAP transporter, solute receptor (TAXI family
M662_14995	COG3290	protein histidine kinase activity
M662_15000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M662_15010	COG0579	oxidoreductase
M662_15020	COG2059	Chromate
M662_15025	COG2059	Chromate
M662_15030	COG1929	Belongs to the glycerate kinase type-1 family
M662_15040	COG1024	Enoyl-CoA hydratase
M662_15045	COG0183	Belongs to the thiolase family
M662_15050	COG1960	acyl-CoA dehydrogenase activity
M662_15075	COG0559	Belongs to the binding-protein-dependent transport system permease family
M662_15080	COG0318	PFAM AMP-dependent synthetase and ligase
M662_15085	COG1028	Short-chain dehydrogenase reductase Sdr
M662_15090	COG0824	Thioesterase
M662_15095	COG1309	transcriptional regulator
M662_15100	COG0183	Belongs to the thiolase family
M662_15105	COG1028	Short-chain dehydrogenase reductase Sdr
M662_15110	COG1960	acyl-CoA dehydrogenase activity
M662_15120	COG2030	dehydratase
M662_15125	COG1028	Short-chain dehydrogenase reductase Sdr
M662_15130	COG1960	acyl-CoA dehydrogenase activity
M662_15135	COG2323	membrane
M662_15150	COG4464	protein tyrosine phosphatase activity
M662_15160	COG5298	Protein conserved in bacteria
M662_15165	COG1215	transferase activity, transferring glycosyl groups
M662_15175	COG1132	(ABC) transporter
M662_15195	COG0803	Belongs to the bacterial solute-binding protein 9 family
M662_15195	COG3443	Belongs to the bacterial solute-binding protein 9 family
M662_15200	COG0745	RESPONSE REGULATOR receiver
M662_15205	COG5002	protein histidine kinase activity
M662_15210	COG0577	efflux transmembrane transporter activity
M662_15215	COG1136	(ABC) transporter
M662_15220	COG4565	transcriptional regulatory protein
M662_15225	COG3290	protein histidine kinase activity
M662_15230	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
M662_15235	COG1461	Dihydroxyacetone kinase
M662_15240	COG2376	Dihydroxyacetone kinase
M662_15245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M662_15250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M662_15260	COG1316	TRANSCRIPTIONal
M662_15265	COG0860	N-Acetylmuramoyl-L-alanine amidase
M662_15265	COG2247	cell wall binding repeat
M662_15270	COG1368	sulfuric ester hydrolase activity
M662_15285	COG1802	Transcriptional regulator
M662_15290	COG2084	Dehydrogenase
M662_15300	COG2610	gluconate transmembrane transporter activity
M662_15340	COG2843	Capsule synthesis protein
M662_15350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M662_15355	COG0737	Belongs to the 5'-nucleotidase family
M662_15360	COG0860	N-Acetylmuramoyl-L-alanine amidase
M662_15360	COG2247	cell wall binding repeat
M662_15365	COG1131	(ABC) transporter
M662_15390	COG0733	neurotransmitter:sodium symporter activity
M662_15405	COG3104	oligopeptide transport
M662_15410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M662_15415	COG0667	Aldo Keto reductase
M662_15440	COG0531	amino acid
M662_15445	COG0697	spore germination
M662_15455	COG2814	Major facilitator Superfamily
M662_15460	COG1309	transcriptional regulator
M662_15465	COG0456	acetyltransferase
M662_15465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M662_15490	COG0800	Aldolase
M662_15495	COG1028	Short-chain dehydrogenase reductase Sdr
M662_15500	COG1312	Catalyzes the dehydration of D-mannonate
M662_15505	COG1904	glucuronate isomerase
M662_15510	COG1501	Belongs to the glycosyl hydrolase 31 family
M662_15535	COG0456	acetyltransferase
M662_15540	COG1028	Short-chain dehydrogenase reductase Sdr
M662_15550	COG0673	inositol 2-dehydrogenase activity
M662_15565	COG1175	transmembrane transport
M662_15570	COG1653	transport
M662_15580	COG1609	Transcriptional regulator
M662_15615	COG4948	Mandelate Racemase Muconate Lactonizing
M662_15620	COG1473	amidohydrolase
M662_15700	COG1388	LysM domain
M662_15705	COG2608	mercury ion transmembrane transporter activity
M662_15710	COG2217	Heavy metal translocating P-type atpase
M662_15715	COG1937	Protein conserved in bacteria
M662_15745	COG0346	lactoylglutathione lyase activity
M662_15810	COG0673	inositol 2-dehydrogenase activity
M662_15815	COG2808	Putative FMN-binding domain
M662_15820	COG0456	acetyltransferase
M662_15825	COG1846	Transcriptional regulator
M662_15830	COG2364	Membrane
M662_15840	COG1522	sequence-specific DNA binding
M662_15845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M662_15895	COG0477	Major facilitator Superfamily
M662_15910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_15915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_15920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M662_15950	COG0110	maltose O-acetyltransferase activity
M662_15980	COG1733	regulation of RNA biosynthetic process
M662_15985	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M662_15990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M662_16000	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_16020	COG2207	Transcriptional regulator
M662_16020	COG3708	Transcriptional regulator
M662_16030	COG1309	transcriptional regulator
M662_16050	COG0494	nUDIX hydrolase
M662_16120	COG2910	NAD(P)H-binding
M662_16125	COG1959	2 iron, 2 sulfur cluster binding
M662_16130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M662_16160	COG3064	Membrane
M662_16180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M662_16215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M662_16220	COG1472	Belongs to the glycosyl hydrolase 3 family
M662_16225	COG1917	Cupin 2, conserved barrel domain protein
M662_16225	COG2207	Transcriptional regulator
M662_16240	COG1620	l-lactate permease
M662_16280	COG1621	beta-fructofuranosidase activity
M662_16285	COG1653	transport
M662_16290	COG0395	ABC-type sugar transport system, permease component
M662_16295	COG4209	transmembrane transport
M662_16300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M662_16315	COG1120	ATPase activity
M662_16320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_16325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M662_16365	COG0305	Participates in initiation and elongation during chromosome replication
M662_16390	COG1012	belongs to the aldehyde dehydrogenase family
M662_16395	COG0191	fructose-bisphosphate aldolase activity
M662_16400	COG2188	Transcriptional regulator
M662_16405	COG0205	6-phosphofructokinase activity
M662_16415	COG1501	Belongs to the glycosyl hydrolase 31 family
M662_16420	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M662_16435	COG0247	lactate metabolic process
M662_16440	COG0277	FAD linked oxidase domain protein
M662_16445	COG1012	belongs to the aldehyde dehydrogenase family
M662_16455	COG4187	Peptidase family M20/M25/M40
M662_16465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M662_16475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M662_16480	COG1802	Transcriptional regulator
M662_16485	COG2706	6-phosphogluconolactonase activity
M662_16490	COG1476	TRANSCRIPTIONal
M662_16525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M662_16535	COG1091	dTDP-4-dehydrorhamnose reductase activity
M662_16540	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M662_16570	COG0110	maltose O-acetyltransferase activity
M662_16585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M662_16590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M662_16595	COG1086	Polysaccharide biosynthesis protein
M662_16600	COG4464	protein tyrosine phosphatase activity
M662_16605	COG0489	protein tyrosine kinase activity
M662_16610	COG3944	biosynthesis protein
M662_16625	COG1134	teichoic acid transport
M662_16630	COG1682	transport, permease protein
M662_16660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M662_16670	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M662_16675	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M662_16680	COG3562	capsule polysaccharide
M662_16705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M662_16710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M662_16715	COG0438	transferase activity, transferring glycosyl groups
M662_16730	COG0728	peptidoglycan biosynthetic process
M662_16745	COG0860	N-Acetylmuramoyl-L-alanine amidase
M662_16745	COG3103	Sh3 type 3 domain protein
M662_16745	COG4991	sh3 domain protein
M662_16765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M662_16775	COG1396	sequence-specific DNA binding
M662_16780	COG1917	Cupin 2, conserved barrel domain protein
M662_16780	COG4977	sequence-specific DNA binding
M662_16795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M662_16800	COG1482	cell wall glycoprotein biosynthetic process
M662_16820	COG0460	homoserine dehydrogenase
M662_16825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M662_16830	COG0083	homoserine kinase activity
M662_16865	COG1070	Carbohydrate kinase
M662_16885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M662_16900	COG1876	peptidase activity
M662_16905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M662_16920	COG3069	C4-dicarboxylate transmembrane transporter activity
M662_16935	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M662_16940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M662_16945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M662_16955	COG1940	carbohydrate kinase activity
M662_16965	COG1940	carbohydrate kinase activity
M662_16970	COG1316	TRANSCRIPTIONal
M662_16990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M662_16995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M662_17000	COG0640	Transcriptional regulator
M662_17005	COG0640	Transcriptional regulator
M662_17010	COG0346	lactoylglutathione lyase activity
M662_17025	COG0454	-acetyltransferase
M662_17035	COG0010	Belongs to the arginase family
M662_17040	COG1228	amidohydrolase
M662_17045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M662_17050	COG2986	histidine ammonia-lyase
M662_17060	COG1082	Xylose isomerase domain protein TIM barrel
M662_17065	COG0673	inositol 2-dehydrogenase activity
M662_17080	COG1609	Transcriptional regulator
M662_17185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M662_17195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M662_17200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M662_17210	COG4786	Flagellar basal body rod
M662_17215	COG4786	Flagellar basal body rod
M662_17220	COG1077	Cell shape determining protein MreB Mrl
M662_17225	COG1609	Transcriptional regulator
M662_17230	COG0739	heme binding
M662_17235	COG2385	sporulation resulting in formation of a cellular spore
M662_17240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M662_17250	COG4836	Membrane
M662_17255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M662_17260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M662_17265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M662_17270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M662_17275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M662_17280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M662_17285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M662_17290	COG0356	it plays a direct role in the translocation of protons across the membrane
M662_17305	COG1404	Belongs to the peptidase S8 family
M662_17310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M662_17315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M662_17320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M662_17325	COG4475	Protein of unknown function (DUF436)
M662_17330	COG0698	ribose 5-phosphate isomerase
M662_17335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M662_17345	COG0009	L-threonylcarbamoyladenylate synthase
M662_17365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M662_17380	COG1435	thymidine kinase activity
M662_17385	COG0254	rRNA binding
M662_17390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M662_17395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M662_17400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M662_17405	COG0191	fructose-bisphosphate aldolase activity
M662_17410	COG2204	response regulator
M662_17415	COG0504	CTP synthase activity
M662_17420	COG3343	RNA polymerase activity
M662_17430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M662_17430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
M662_17430	COG1703	isobutyryl-CoA mutase activity
M662_17445	COG1960	acyl-CoA dehydrogenase activity
M662_17450	COG1960	acyl-CoA dehydrogenase activity
M662_17455	COG1250	3-hydroxyacyl-CoA dehydrogenase
M662_17460	COG0183	Belongs to the thiolase family
M662_17465	COG0247	lactate metabolic process
M662_17465	COG2181	nitrate reductase activity
M662_17470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M662_17480	COG0018	arginyl-trna synthetase
M662_17495	COG0010	Belongs to the arginase family
M662_17500	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M662_17505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M662_17525	COG3465	dGTPase activity
M662_17530	COG1078	dGTPase activity
M662_17535	COG0095	Lipoate-protein ligase
M662_17550	COG0280	phosphate acetyltransferase
M662_17560	COG3773	Cell wall hydrolase
M662_17575	COG2363	Small membrane protein
M662_17585	COG0733	neurotransmitter:sodium symporter activity
M662_17630	COG3594	Acyltransferase
M662_17650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M662_17650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M662_17655	COG0307	riboflavin synthase, alpha
M662_17660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M662_17660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M662_17670	COG0366	Alpha amylase catalytic
M662_17675	COG1764	response to oxidative stress
M662_17690	COG0861	Integral membrane protein TerC family
M662_17695	COG2195	Cleaves the N-terminal amino acid of tripeptides
M662_17700	COG0628	permease
M662_17725	COG1114	Component of the transport system for branched-chain amino acids
M662_17735	COG2308	Evidence 4 Homologs of previously reported genes of
M662_17740	COG0604	alcohol dehydrogenase
M662_17745	COG0514	ATP-dependent DNA helicase (RecQ)
M662_17750	COG3844	kynureninase activity
M662_17755	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M662_17760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M662_17785	COG0488	(ABC) transporter
M662_17790	COG1115	amino acid carrier protein
M662_17795	COG1840	ABC-type Fe3 transport system, periplasmic component
M662_17805	COG3842	ATPase activity
M662_17810	COG1607	acyl-coa hydrolase
M662_17815	COG5002	protein histidine kinase activity
M662_17820	COG0745	RESPONSE REGULATOR receiver
M662_17825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M662_17830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M662_17835	COG1827	regulation of RNA biosynthetic process
M662_17840	COG1621	beta-fructofuranosidase activity
M662_17845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M662_17850	COG2190	(PTS) system
M662_17855	COG0626	cystathionine gamma-synthase activity
M662_17860	COG2814	Major facilitator Superfamily
M662_17870	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M662_17875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M662_17875	COG0723	plastoquinol--plastocyanin reductase activity
M662_17880	COG2962	Rard protein
M662_17890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M662_17895	COG1309	transcriptional regulator
M662_17915	COG2873	o-acetylhomoserine
M662_17920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M662_17945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M662_17950	COG2197	response regulator
M662_17955	COG4585	Histidine kinase
M662_17965	COG1842	Phage shock protein A
M662_17990	COG0840	transmembrane signaling receptor activity
M662_17995	COG0006	proline dipeptidase activity
M662_18005	COG1268	BioY protein
M662_18020	COG2755	lipolytic protein G-D-S-L family
M662_18030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M662_18035	COG2860	membrane
M662_18050	COG3361	conserved protein (COG2071)
M662_18055	COG0346	lactoylglutathione lyase activity
M662_18060	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M662_18075	COG2188	Transcriptional regulator
M662_18080	COG0366	Alpha amylase catalytic
M662_18085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M662_18085	COG1263	PTS System
M662_18090	COG2814	Major facilitator Superfamily
M662_18095	COG1335	isochorismatase
M662_18110	COG0351	phosphomethylpyrimidine kinase
M662_18115	COG3695	enzyme binding
M662_18125	COG0702	epimerase
M662_18135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M662_18140	COG1012	belongs to the aldehyde dehydrogenase family
M662_18150	COG0596	Alpha beta hydrolase
M662_18165	COG2130	NADP-dependent
M662_18170	COG1366	Belongs to the anti-sigma-factor antagonist family
M662_18180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M662_18185	COG0512	Glutamine amidotransferase of anthranilate synthase
M662_18195	COG2204	response regulator
M662_18205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M662_18220	COG3300	MHYT domain
M662_18220	COG5001	Diguanylate cyclase
M662_18225	COG2340	Cysteine-rich secretory protein family
M662_18230	COG0513	Belongs to the DEAD box helicase family
M662_18240	COG1757	Na H antiporter
M662_18250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M662_18255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M662_18260	COG0505	Belongs to the CarA family
M662_18270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M662_18275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M662_18280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M662_18290	COG0456	acetyltransferase
M662_18305	COG1132	(ABC) transporter
M662_18310	COG1132	(ABC) transporter
M662_18320	COG1733	regulation of RNA biosynthetic process
M662_18325	COG0673	inositol 2-dehydrogenase activity
M662_18335	COG2340	Cysteine-rich secretory protein family
M662_18345	COG4989	oxidoreductase activity
M662_18350	COG0352	thiamine-phosphate diphosphorylase activity
M662_18355	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M662_18365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M662_18390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M662_18395	COG1793	dna ligase
M662_18395	COG3285	dna ligase
M662_18410	COG0561	phosphatase activity
M662_18415	COG1473	amidohydrolase
M662_18420	COG1464	Belongs to the NlpA lipoprotein family
M662_18425	COG2011	ABC-type metal ion transport system permease component
M662_18440	COG2323	membrane
M662_18445	COG1937	Protein conserved in bacteria
M662_18450	COG2210	Belongs to the sulfur carrier protein TusA family
M662_18455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M662_18460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M662_18460	COG0425	Belongs to the sulfur carrier protein TusA family
M662_18465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M662_18465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M662_18470	COG0425	Belongs to the sulfur carrier protein TusA family
M662_18475	COG0730	response to heat
M662_18480	COG1368	sulfuric ester hydrolase activity
M662_18485	COG1268	BioY protein
M662_18525	COG0739	heme binding
M662_18525	COG0741	lytic transglycosylase activity
M662_18525	COG1196	nuclear chromosome segregation
M662_18530	COG2177	Part of the ABC transporter FtsEX involved in
M662_18540	COG1794	racemase activity, acting on amino acids and derivatives
M662_18545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M662_18565	COG0493	'glutamate synthase
M662_18570	COG0067	glutamate synthase
M662_18570	COG0069	glutamate synthase activity
M662_18570	COG0070	glutamate synthase
M662_18580	COG1295	ribonuclease BN
M662_18585	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M662_18595	COG3103	Sh3 type 3 domain protein
M662_18595	COG0366	Alpha amylase catalytic
M662_18600	COG0058	SHG alpha-glucan phosphorylase activity
M662_18605	COG0297	glycogen (starch) synthase activity
M662_18610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M662_18615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M662_18620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M662_18640	COG0840	transmembrane signaling receptor activity
M662_18645	COG0702	epimerase
M662_18655	COG1301	dicarboxylic acid transport
M662_18660	COG2814	Major facilitator Superfamily
M662_18665	COG2329	Antibiotic biosynthesis monooxygenase
M662_18670	COG2508	Transcriptional regulator
M662_18675	COG1012	belongs to the aldehyde dehydrogenase family
M662_18680	COG0506	proline dehydrogenase activity
M662_18685	COG3239	Fatty acid desaturase
M662_18690	COG4585	Histidine kinase
M662_18695	COG2197	response regulator
M662_18700	COG0840	transmembrane signaling receptor activity
M662_18715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M662_18720	COG0745	RESPONSE REGULATOR receiver
M662_18725	COG0642	Histidine kinase
M662_18730	COG1136	(ABC) transporter
M662_18735	COG0577	efflux transmembrane transporter activity
M662_18775	COG0791	NLP P60 protein
M662_18775	COG0741	lytic transglycosylase activity
M662_18850	COG5002	protein histidine kinase activity
M662_18860	COG0415	Belongs to the DNA photolyase family
M662_18895	COG2311	Membrane
M662_18900	COG1846	Transcriptional regulator
M662_18905	COG1764	response to oxidative stress
M662_18910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M662_18915	COG2814	Major facilitator Superfamily
M662_18920	COG0617	tRNA 3'-terminal CCA addition
M662_18920	COG0517	IMP dehydrogenase activity
M662_18920	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M662_18925	COG1846	Transcriptional regulator
M662_18930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M662_18930	COG2755	lipolytic protein G-D-S-L family
M662_18935	COG0450	alkyl hydroperoxide reductase
M662_18940	COG3634	alkyl hydroperoxide reductase activity
M662_18955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M662_18965	COG2313	pseudouridylate synthase activity
M662_18970	COG0579	oxidoreductase
M662_18980	COG1346	cytolysis
M662_18985	COG1380	Effector of murein hydrolase LrgA
M662_18990	COG3706	GGDEF domain
M662_18995	COG0596	Alpha beta hydrolase
M662_19000	COG0305	Participates in initiation and elongation during chromosome replication
M662_19015	COG1914	H( )-stimulated, divalent metal cation uptake system
M662_19020	COG2814	Major facilitator Superfamily
M662_19025	COG0277	FAD linked oxidase domain protein
M662_19085	COG1104	cysteine desulfurase activity
M662_19095	COG0419	ATPase involved in DNA repair
M662_19125	COG1473	amidohydrolase
M662_19130	COG1288	antiporter activity
M662_19160	COG0069	glutamate synthase activity
M662_19165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M662_19175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M662_19180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M662_19185	COG0246	Mannitol dehydrogenase
M662_19190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M662_19195	COG2213	PTS system mannitol-specific
M662_19220	COG1266	CAAX protease self-immunity
M662_19225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M662_19230	COG2814	Major facilitator Superfamily
M662_19235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M662_19245	COG2610	gluconate transmembrane transporter activity
M662_19250	COG0183	Belongs to the thiolase family
M662_19255	COG1028	Short-chain dehydrogenase reductase Sdr
M662_19265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M662_19275	COG0501	Belongs to the peptidase M48B family
M662_19290	COG1115	amino acid carrier protein
M662_19295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M662_19300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M662_19305	COG4853	Protein conserved in bacteria
M662_19315	COG5002	protein histidine kinase activity
M662_19320	COG0745	RESPONSE REGULATOR receiver
M662_19330	COG1196	nuclear chromosome segregation
M662_19330	COG0741	lytic transglycosylase activity
M662_19330	COG0739	heme binding
M662_19350	COG1611	Belongs to the LOG family
M662_19355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M662_19360	COG1349	DNA-binding transcription factor activity
M662_19365	COG0561	phosphatase activity
M662_19370	COG0305	Participates in initiation and elongation during chromosome replication