locus-tag class description AUL54_00005 ENOG4106J9J DNA polymerase AUL54_00105 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AUL54_00110 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AUL54_00130 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AUL54_00135 ENOG4106ITI Glutaredoxin AUL54_00145 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AUL54_00165 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AUL54_00170 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AUL54_00250 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AUL54_00290 ENOG41065KQ synthase AUL54_00300 ENOG410890F Dynamin family AUL54_00320 ENOG41081VK Ribonuclease AUL54_00360 ENOG4105CVG Homoserine O-transsuccinylase AUL54_00365 ENOG4108V06 Glutathione peroxidase AUL54_00380 ENOG4105C01 Dihydroxy-acid dehydratase AUL54_00385 ENOG4108Y6J UPF0403 protein AUL54_00390 ENOG4107YX5 Pfam:DUF548 AUL54_00400 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AUL54_00405 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AUL54_00415 ENOG4108UT2 hemolysin iii AUL54_00425 ENOG4105C7B Threonine dehydratase AUL54_00435 ENOG4108KF3 Electron transport protein SCO1 SenC AUL54_00440 ENOG41090WU lipolytic protein G-D-S-L family AUL54_00445 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) AUL54_00455 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AUL54_00460 ENOG4105E0X reductase AUL54_00500 ENOG4106BHF AUL54_00505 ENOG4106ANW SMI1_KNR4 AUL54_00535 ENOG410780I phosphoprotein phosphatase activity AUL54_00570 ENOG41080V3 Major Facilitator superfamily AUL54_00615 ENOG4105FTQ Dna gyrase AUL54_00620 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AUL54_00635 ENOG4107S4Y M20 DapE family protein YgeY AUL54_00640 ENOG4108TSC N-acetyltransferase AUL54_00645 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AUL54_00665 ENOG410841Q phosphoesterase PA-phosphatase related protein AUL54_00670 ENOG4106Z5R AUL54_00675 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AUL54_00680 ENOG4108VXD carboxy-peptidase AUL54_00700 ENOG4108S3Y transcriptional regulator AUL54_00705 ENOG4105CS2 ec 3.2.1.21 AUL54_00715 ENOG4105E1V na solute symporter AUL54_00730 ENOG4105FBA Phospholipase Carboxylesterase AUL54_00775 ENOG4106SCS STAS domain AUL54_00780 ENOG4107QMU Mate efflux family protein AUL54_00790 ENOG41087PP glycosyltransferase MGT family AUL54_00795 ENOG4105K4H Nlp p60 protein AUL54_00805 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AUL54_00810 ENOG4107T89 von Willebrand factor, type A AUL54_00815 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AUL54_00820 ENOG4105C7S Dehydrogenase AUL54_00830 ENOG4105C09 Bile acid AUL54_00835 ENOG4105C8J )-transporter AUL54_00840 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AUL54_00845 ENOG4105EWU Squalene--hopene cyclase AUL54_00850 ENOG4105C26 Dehydrogenase AUL54_00890 ENOG4105SCY DNAK suppressor AUL54_00895 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AUL54_00905 ENOG4105C9U ATP-dependent DNA helicase RecQ AUL54_00910 ENOG41069ER domain protein AUL54_00935 ENOG4108SJC Membrane AUL54_00945 ENOG4105KTU Transcriptional regulator, arsr family AUL54_00955 ENOG4108W8B Beta-lactamase domain protein AUL54_00965 ENOG4105FTV AraC Family Transcriptional Regulator AUL54_00970 ENOG4108Z7R Chaperone CsaA AUL54_01095 ENOG4108FKH Transglycosylase SLT domain AUL54_01115 ENOG41068G1 AUL54_01135 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AUL54_01185 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AUL54_01190 ENOG4106BHF AUL54_01195 ENOG4106ANW SMI1_KNR4 AUL54_01220 ENOG4108J2R molybdopterin oxidoreductase AUL54_01225 ENOG4108M3J Dehydrogenase AUL54_01235 ENOG4105IE8 Alpha-ketoglutarate permease AUL54_01240 ENOG4108UB7 AUL54_01265 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AUL54_01270 ENOG4105C5Q Transcriptional regulator AUL54_01275 ENOG4105CBC glutamate synthase AUL54_01280 ENOG4105BZ8 glutamate synthase AUL54_01290 ENOG4105CB2 alcohol dehydrogenase AUL54_01295 ENOG4108KSA LysR family transcriptional regulator AUL54_01300 ENOG4105C22 threonyL-tRNA synthetase AUL54_01305 ENOG4105WAB arsR family transcriptional regulator AUL54_01310 ENOG4108RWP Major Facilitator Superfamily protein AUL54_01315 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AUL54_01340 ENOG4107QJQ Mate efflux family protein AUL54_01345 ENOG4108N2V aldose 1-epimerase AUL54_01350 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family AUL54_01355 ENOG4105C0W non-ribosomal peptide synthetase AUL54_01365 ENOG4105C0W non-ribosomal peptide synthetase AUL54_01370 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_01380 ENOG4106U2H Protein of unknown function (DUF1360) AUL54_01385 ENOG4105F32 YngK protein AUL54_01390 ENOG4105C1G acyl-Coa dehydrogenase AUL54_01395 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_01400 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AUL54_01405 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AUL54_01410 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AUL54_01415 ENOG4105E39 Enoyl-CoA hydratase AUL54_01420 ENOG4107QX3 carboxylase AUL54_01425 ENOG4107T5V SNARE associated Golgi AUL54_01430 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AUL54_01445 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AUL54_01450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AUL54_01455 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AUL54_01460 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AUL54_01465 ENOG4106A3M Cytochrome p-450 AUL54_01470 ENOG4105CY2 Citrate transporter AUL54_01475 ENOG4105D6N CoA-transferase, subunit a AUL54_01480 ENOG4108IIH CoA-transferase subunit B AUL54_01485 ENOG4105DTD Dehydrogenase AUL54_01510 ENOG4107SYN Glycosyl hydrolases family 43 AUL54_01565 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AUL54_01570 ENOG4105K4P CoA-binding domain protein AUL54_01575 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AUL54_01580 ENOG4105W8X HesB YadR YfhF-family protein AUL54_01585 ENOG4105MI2 AUL54_01595 ENOG41067CD Small, acid-soluble spore protein Tlp AUL54_01605 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AUL54_01610 ENOG4108I0Z Aconitate hydratase AUL54_01645 ENOG4107QIV Cytochrome c biogenesis protein AUL54_01655 ENOG4105VXM UPF0154 protein AUL54_01665 ENOG4105CV1 Transketolase (EC 2.2.1.1) AUL54_01670 ENOG4105VPS UPF0291 protein AUL54_01675 ENOG4108SVB resolvase AUL54_01685 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AUL54_01710 ENOG4105K7W phage-related replication protein AUL54_01715 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AUL54_01730 ENOG41068WN AUL54_01735 ENOG4108M1A Chitin-binding protein AUL54_01755 ENOG4105EPI acetyltransferase, (GNAT) family AUL54_01775 ENOG4105MXK Carbon dioxide concentrating mechanism protein AUL54_01780 ENOG4105DQ4 alcohol dehydrogenase AUL54_01785 ENOG4105SF0 DinB family AUL54_01790 ENOG4105D29 Helix-turn-helix type 11 domain protein AUL54_01805 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AUL54_01810 ENOG4105CMG Carbohydrate kinase AUL54_01815 ENOG4105C93 Xylose Isomerase AUL54_01825 ENOG4105DSG hydrolase family 43 AUL54_01830 ENOG4105CT4 transporter AUL54_01860 ENOG4105C5F glutamine synthetase AUL54_01865 ENOG4105KV4 Transcriptional regulator AUL54_01870 ENOG4105CXI aluminum resistance protein AUL54_01875 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AUL54_01880 ENOG4106F1P AAA ATPase, central domain protein AUL54_01890 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AUL54_01895 ENOG4105U6W MutT NUDIX family protein AUL54_01900 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AUL54_01905 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AUL54_01930 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AUL54_01955 ENOG4108X3M OsmC Ohr family protein AUL54_01960 ENOG4105K7W phage-related replication protein AUL54_01970 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AUL54_01980 ENOG4105XPP Protein of unknown function (DUF1275) AUL54_01985 ENOG4105WFK nuclease AUL54_01990 ENOG4106A3M Cytochrome p-450 AUL54_02000 ENOG4105C0W non-ribosomal peptide synthetase AUL54_02010 ENOG4107SQU synthase AUL54_02015 ENOG4105C0W non-ribosomal peptide synthetase AUL54_02020 ENOG4108KQ6 Enoyl-CoA hydratase AUL54_02025 ENOG4108MGH Enoyl-CoA hydratase AUL54_02030 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase AUL54_02035 ENOG41062T2 Acyl carrier protein AUL54_02040 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AUL54_02045 ENOG4108JA1 polyketide synthase AUL54_02050 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AUL54_02055 ENOG4108151 Beta-lactamase domain protein AUL54_02095 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AUL54_02115 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AUL54_02120 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AUL54_02125 ENOG4105CPQ Dehydrogenase AUL54_02130 ENOG4105MCT stage V sporulation protein S AUL54_02135 ENOG4105D48 metallophosphoesterase AUL54_02145 ENOG4108A04 Beta-lactamase AUL54_02150 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AUL54_02155 ENOG4105CEV competence damage-inducible protein AUL54_02160 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AUL54_02175 ENOG4105XZV Protein of unknown function (DUF3243) AUL54_02180 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AUL54_02195 ENOG4105EYF MMPL domain protein AUL54_02210 ENOG4105FDP GntR family transcriptional regulator AUL54_02215 ENOG4105CNU cell division protein FtsK AUL54_02225 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AUL54_02235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AUL54_02245 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AUL54_02250 ENOG4108S0H Dipicolinic acid synthetase, b subunit AUL54_02255 ENOG4105E35 Dipicolinate synthase subunit A AUL54_02265 ENOG4105C1V Peptidase, M16 AUL54_02275 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AUL54_02280 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AUL54_02285 ENOG4105DTN riboflavin biosynthesis protein ribF AUL54_02290 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AUL54_02295 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AUL54_02300 ENOG4105W7A Protein of unknown function (DUF503) AUL54_02305 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AUL54_02310 ENOG4105VHM ribosomal protein AUL54_02315 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AUL54_02320 ENOG4105CHV Transcription elongation factor NusA AUL54_02325 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AUL54_02330 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AUL54_02335 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AUL54_02340 ENOG4105DZP Membrane-associated zinc metalloprotease AUL54_02350 ENOG4105KNE Phosphatidate cytidylyltransferase AUL54_02355 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AUL54_02360 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AUL54_02365 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AUL54_02375 ENOG4105CE9 30S ribosomal protein S2 AUL54_02385 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AUL54_02390 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AUL54_02400 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis AUL54_02405 ENOG4105CBS Chea signal transduction histidine kinase AUL54_02410 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AUL54_02420 ENOG4105FZW flagellar biosynthesis regulator FlhF AUL54_02425 ENOG4105D7B Flagellar biosynthesis protein flha AUL54_02430 ENOG4105D00 flagellar biosynthetic protein flhB AUL54_02435 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AUL54_02440 ENOG4105VS8 Flagellar biosynthetic protein fliq AUL54_02445 ENOG4105CN7 Flagellar biosynthetic protein FliP AUL54_02455 ENOG4107YTP response regulator receiver protein AUL54_02460 ENOG4105DD5 Flagellar motor switch protein AUL54_02465 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AUL54_02475 ENOG41068WV flagellar FlbD family protein AUL54_02480 ENOG4108JQA flagellar AUL54_02485 ENOG410822I Flagellar hook capping protein AUL54_02490 ENOG410696Y Flagellar hook-length control protein AUL54_02500 ENOG4106YF4 Flagellar biosynthesis chaperone AUL54_02515 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AUL54_02520 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AUL54_02525 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AUL54_02530 ENOG4108ZC9 flagellar basal-body rod protein flgc AUL54_02535 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AUL54_02545 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AUL54_02550 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AUL54_02555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AUL54_02560 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AUL54_02565 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AUL54_02570 ENOG4105C79 DNA protecting protein DprA AUL54_02575 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AUL54_02580 ENOG4105CMV Succinyl-CoA synthetase subunit beta AUL54_02585 ENOG4105VM1 flagellar AUL54_02595 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AUL54_02600 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AUL54_02605 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AUL54_02610 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AUL54_02625 ENOG4108BW8 UPF0109 protein AUL54_02630 ENOG4105K5M 30s ribosomal protein S16 AUL54_02640 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) AUL54_02650 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AUL54_02655 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AUL54_02660 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AUL54_02665 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AUL54_02670 ENOG4105CHR reductase AUL54_02675 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AUL54_02680 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AUL54_02685 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) AUL54_02690 ENOG4105CB5 ATP-dependent DNA helicase recG AUL54_02695 ENOG4105EJQ L-serine dehydratase AUL54_02705 ENOG4105DP4 dak2 domain fusion protein ylov AUL54_02710 ENOG4108ZAA Alkaline-shock protein AUL54_02715 ENOG4105VB9 50S ribosomal protein l28 AUL54_02725 ENOG4105FJ0 thiamine AUL54_02730 ENOG4105DJV ribulose-phosphate 3-epimerase AUL54_02735 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AUL54_02740 ENOG4105D9P serine threonine protein kinase AUL54_02745 ENOG4108ZF3 Phosphatase AUL54_02750 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AUL54_02755 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AUL54_02760 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AUL54_02765 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AUL54_02770 ENOG4105C25 Primosomal protein n' AUL54_02775 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AUL54_02785 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AUL54_02790 ENOG4105KC4 UPF0296 protein AUL54_02795 ENOG4105DSJ YicC domain protein AUL54_02805 ENOG4105F23 Fibronectin-binding protein AUL54_02815 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AUL54_02820 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AUL54_02825 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AUL54_02835 ENOG4107RIQ Sulfate adenylate transferase AUL54_02850 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AUL54_02855 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AUL54_02860 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AUL54_02865 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AUL54_02870 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AUL54_02875 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AUL54_02885 ENOG4105CXT aspartate transcarbamylase AUL54_02895 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AUL54_02900 ENOG4105C34 Pseudouridine synthase AUL54_02905 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AUL54_02915 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AUL54_02925 ENOG4105DBK s4 domain protein AUL54_02930 ENOG41067XK integral membrane protein AUL54_02935 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AUL54_02940 ENOG4105DFA alanine racemase domain protein AUL54_02945 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AUL54_02950 ENOG4105WR5 sporulation protein, YlmC YmxH family AUL54_02960 ENOG4105DKW ABC transporter AUL54_02970 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AUL54_02975 ENOG4105FFI sigma-e processing peptidase spoiiga AUL54_02985 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AUL54_02990 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AUL54_02995 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AUL54_03000 ENOG4105D4A Cell wall formation (By similarity) AUL54_03005 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AUL54_03010 ENOG4105CNI cell division protein FtsW AUL54_03015 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AUL54_03020 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AUL54_03025 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AUL54_03030 ENOG4105CJN penicillin-binding protein AUL54_03035 ENOG4105CJN penicillin-binding protein AUL54_03045 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AUL54_03050 ENOG4108V6E Cell division protein mraZ AUL54_03075 ENOG4105KNH Nucleic acid-binding protein AUL54_03080 ENOG4105CDE UPF0348 protein AUL54_03085 ENOG41063PX domain protein AUL54_03090 ENOG4105D78 K07001 NTE family protein AUL54_03095 ENOG4105H20 Sporulation integral membrane protein YlbJ AUL54_03100 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AUL54_03105 ENOG4106H78 methyltransferase AUL54_03130 ENOG4106UY4 Inherit from COG: Scp-like extracellular AUL54_03135 ENOG41080XQ Signal transduction protein with cbs domains AUL54_03150 ENOG41064X9 cytochrome C oxidase subunit IV AUL54_03155 ENOG4105CCU oxidase (Subunit III) AUL54_03160 ENOG4105BZ9 Cytochrome C oxidase, subunit I AUL54_03170 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AUL54_03180 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AUL54_03185 ENOG4105CNI cell division protein FtsW AUL54_03195 ENOG4105CSV Glutaminase AUL54_03205 ENOG4108IAB Phoh family AUL54_03220 ENOG4105QA2 AUL54_03225 ENOG4105CI3 gtp-binding protein typa AUL54_03270 ENOG4105D4Y metalloprotease AUL54_03280 ENOG4105ECY inositol monophosphatase AUL54_03295 ENOG4105WBI UPF0223 protein AUL54_03300 ENOG4105CXN decarboxylase AUL54_03315 ENOG4107QN2 dihydrolipoyl dehydrogenase AUL54_03320 ENOG4105C7S Dehydrogenase AUL54_03325 ENOG4105CPP Dehydrogenase, E1 component AUL54_03335 ENOG4105FQP Beta-lactamase AUL54_03340 ENOG4105C0W non-ribosomal peptide synthetase AUL54_03345 ENOG4107SQU synthase AUL54_03350 ENOG4107SQU synthase AUL54_03355 ENOG4107SQU synthase AUL54_03360 ENOG4105C0W non-ribosomal peptide synthetase AUL54_03365 ENOG4107SQU synthase AUL54_03370 ENOG4105C0W non-ribosomal peptide synthetase AUL54_03375 ENOG4107QKG PfaD family AUL54_03390 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AUL54_03395 ENOG4108X4Q Hydrolase AUL54_03400 ENOG4106148 UPF0356 protein AUL54_03405 ENOG4105CN5 Metallo-Beta-Lactamase AUL54_03410 ENOG4105CPN adenine deaminase AUL54_03415 ENOG4107ZYR domain protein AUL54_03425 ENOG4105BZU Histidine kinase AUL54_03450 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AUL54_03455 ENOG4105C5H ABC transporter AUL54_03470 ENOG4105DM4 PTS System AUL54_03475 ENOG4105DE4 1-phosphofructokinase AUL54_03480 ENOG4105E98 transcriptional regulator DeoR family AUL54_03485 ENOG4107RBB ABC transporter, permease AUL54_03490 ENOG4105C19 ABC transporter AUL54_03495 ENOG4107X8C Efflux transporter RND family MFP subunit AUL54_03505 ENOG41067WU Molybdopterin converting factor (Subunit 1) AUL54_03510 ENOG4108ZAF Molybdopterin AUL54_03515 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AUL54_03520 ENOG4105CVM Molybdenum cofactor synthesis domain protein AUL54_03525 ENOG4105D06 uba thif-type nad fad binding protein AUL54_03530 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AUL54_03545 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AUL54_03550 ENOG4105D8X mechanosensitive ion channel AUL54_03570 ENOG4105NQC Flavodoxin AUL54_03600 ENOG4108XRC Protein of unknown function (DUF458) AUL54_03605 ENOG4107IN1 Protein of unknown function (DUF1797) AUL54_03615 ENOG4105EPM Diguanylate phosphodiesterase AUL54_03625 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AUL54_03635 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein AUL54_03645 ENOG4105UIN AUL54_03650 ENOG4107R88 Chemotaxis protein (CheV) AUL54_03655 ENOG4105CHM Aminotransferase AUL54_03660 ENOG4105BZU Histidine kinase AUL54_03670 ENOG4105K4I Scp-like extracellular AUL54_03680 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AUL54_03685 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AUL54_03690 ENOG4105F6S Spore photoproduct lyase AUL54_03700 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AUL54_03705 ENOG4105KRI phosphocarrier protein (HPr AUL54_03715 ENOG4105CID antiterminator AUL54_03725 ENOG4105DC7 peptidase M24 AUL54_03730 ENOG4105C59 p-type ATPase AUL54_03745 ENOG4105F0V Cell wall hydrolase AUL54_03770 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AUL54_03780 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AUL54_03785 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AUL54_03790 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase AUL54_03795 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AUL54_03805 ENOG4108K88 Membrane AUL54_03815 ENOG4105E14 MotA TolQ exbB proton channel AUL54_03820 ENOG4105ER2 Ompa motb domain protein AUL54_03825 ENOG41090MY MarR family Transcriptional regulator AUL54_03830 ENOG4105BZU Histidine kinase AUL54_03840 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AUL54_03845 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AUL54_03850 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) AUL54_03855 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate AUL54_03865 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AUL54_03875 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AUL54_03880 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AUL54_03885 ENOG4105BZU Histidine kinase AUL54_03890 ENOG4108TGC Acyltransferase AUL54_03895 ENOG410900G Protein of unknown function (DUF421) AUL54_03905 ENOG4105D0M Protease HtpX homolog AUL54_03915 ENOG410681C small acid-soluble spore protein AUL54_03925 ENOG4108WZW RNA polymerase sigma AUL54_03930 ENOG4107TS3 membrane protein, TerC AUL54_03935 ENOG4107T5V SNARE associated Golgi AUL54_03940 ENOG4105BZU Histidine kinase AUL54_03945 ENOG4105FDF Could be involved in DNA repair (By similarity) AUL54_03950 ENOG4105DQE DNA ligase AUL54_03970 ENOG4105V75 Transcriptional regulator AUL54_03975 ENOG4105CJW magnesium transporter AUL54_03980 ENOG4105VRS hydrolase family 18 AUL54_03985 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein AUL54_03990 ENOG4108JJB ABC transporter AUL54_03995 ENOG4108W7F transporter, permease AUL54_04005 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AUL54_04010 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AUL54_04020 ENOG4105D8G Major Facilitator superfamily AUL54_04025 ENOG4107Y2X deaminase AUL54_04035 ENOG4107TVC Glycosyl transferase, family 2 AUL54_04050 ENOG4108ZHJ Organic hydroperoxide resistance protein AUL54_04055 ENOG4105K56 Transcriptional regulator AUL54_04070 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AUL54_04075 ENOG4105CIY formyltetrahydrofolate deformylase AUL54_04080 ENOG41080TC multidrug resistance protein AUL54_04090 ENOG4108428 Inherit from COG: -acetyltransferase AUL54_04095 ENOG4108S4H thioesterase Superfamily protein AUL54_04100 ENOG4107TUM Amidinotransferase AUL54_04105 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AUL54_04110 ENOG4108JQ7 (ABC) transporter AUL54_04115 ENOG4107SN7 NLP P60 protein AUL54_04120 ENOG4105DTQ mandelate racemase muconate lactonizing AUL54_04125 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AUL54_04135 ENOG4105C3U ABC transporter AUL54_04140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AUL54_04145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AUL54_04150 ENOG4108ME1 Peptidase M55 D-aminopeptidase AUL54_04160 ENOG4105C0H protease AUL54_04165 ENOG4105CKK Glycosyl transferase, family 2 AUL54_04170 ENOG4105EDW glycosyl transferase, family 39 AUL54_04180 ENOG4107R7I amino acid AUL54_04185 ENOG4107GRR phosphate transport regulator AUL54_04190 ENOG4105CJ3 phosphate transporter AUL54_04205 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AUL54_04235 ENOG41068G1 AUL54_04245 ENOG410906S phage-like element pbsx protein xkdt AUL54_04250 ENOG41066EA baseplate J family protein AUL54_04255 ENOG4105MFU Protein of unknown function (DUF2634) AUL54_04265 ENOG4105X7F AUL54_04270 ENOG4108WZM domain protein AUL54_04275 ENOG4108FKH Transglycosylase SLT domain AUL54_04275 ENOG4108FKH Transglycosylase SLT domain AUL54_04275 ENOG4108FKH Transglycosylase SLT domain AUL54_04280 ENOG4105MTC XkdN-like protein AUL54_04285 ENOG4105FR7 XkdM protein, phage-like element PBSX AUL54_04290 ENOG4105PQS phage protein AUL54_04305 ENOG41060SN AUL54_04330 ENOG4108MDF Phage Portal Protein AUL54_04335 ENOG4105IG6 Phage terminase, large subunit AUL54_04340 ENOG4108TFU terminase (Small subunit) AUL54_04380 ENOG410635T phage-like element pbsx protein AUL54_04385 ENOG4105K7W phage-related replication protein AUL54_04390 ENOG4105KWG Pfam:DUF1696 AUL54_04395 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AUL54_04415 ENOG4107TSN permease AUL54_04425 ENOG4107KJX Transcriptional regulator AUL54_04440 ENOG4105Q95 Cupin 2, conserved barrel domain protein AUL54_04450 ENOG4108IXI (ABC) transporter AUL54_04455 ENOG4105C4B ABC transporter, permease AUL54_04460 ENOG4105EXQ uroporphyrinogen iii synthase hem4 AUL54_04470 ENOG41087PP glycosyltransferase MGT family AUL54_04475 ENOG4106A3M Cytochrome p-450 AUL54_04485 ENOG4108IEG Formate dehydrogenase Alpha subunit AUL54_04500 ENOG4105KT7 mgtC SapB transporter AUL54_04520 ENOG4105E98 transcriptional regulator DeoR family AUL54_04525 ENOG4105CS2 ec 3.2.1.21 AUL54_04530 ENOG4105VCP PTS System AUL54_04535 ENOG4105CK1 PTS System AUL54_04540 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AUL54_04545 ENOG4105CMR udp-glucose 4-epimerase AUL54_04550 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase AUL54_04565 ENOG4105C0R drug resistance transporter emrb qaca subfamily AUL54_04665 ENOG4105C28 cystathionine AUL54_04670 ENOG4105C28 cystathionine AUL54_04680 ENOG4108ZMI UPF0477 protein AUL54_04695 ENOG4105CJ1 ABC, transporter AUL54_04710 ENOG4105ENA helicase AUL54_04760 ENOG4107A88 AUL54_04765 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AUL54_04770 ENOG4105DWF phosphomethylpyrimidine kinase AUL54_04775 ENOG4105D06 uba thif-type nad fad binding protein AUL54_04795 ENOG4108VEU Thiamine monophosphate synthase AUL54_04800 ENOG4105ETU transcriptional activator (TenA AUL54_04810 ENOG4107S1Q Phosphatase AUL54_04815 ENOG4105EMS pseudouridine synthase AUL54_04820 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AUL54_04835 ENOG4105MIX Adenylate cyclase AUL54_04840 ENOG4105E4C Lytic transglycosylase catalytic AUL54_04845 ENOG4108Z18 K06886 hemoglobin AUL54_04850 ENOG4105T58 Dithiol-disulfide isomerase AUL54_04855 ENOG4105DPN Oligoendopeptidase f AUL54_04865 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis AUL54_04870 ENOG4108ZCF integral membrane protein AUL54_04875 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) AUL54_04890 ENOG4108JQ7 (ABC) transporter AUL54_04900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AUL54_04905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AUL54_04910 ENOG4108J59 Extracellular solute-binding protein, family 5 AUL54_04915 ENOG4105C31 Tryptophanyl-tRNA synthetase AUL54_04925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AUL54_04940 ENOG4108JQ7 (ABC) transporter AUL54_04945 ENOG4105C3U ABC transporter AUL54_04955 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AUL54_04960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AUL54_04975 ENOG4107RMD Basic membrane lipoprotein AUL54_05000 ENOG4105DBV ornithine carbamoyltransferase AUL54_05010 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AUL54_05015 ENOG4105C8Y Acetylornithine aminotransferase AUL54_05020 ENOG4105CAS nag kinase AUL54_05030 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AUL54_05040 ENOG4105IQ5 FAD linked oxidase domain protein AUL54_05050 ENOG4105VG1 fes assembly suf system protein AUL54_05055 ENOG4108MXZ Esterase AUL54_05060 ENOG4108KP7 hydrolase AUL54_05065 ENOG41073B9 AUL54_05075 ENOG4107AYK membrAne AUL54_05085 ENOG4105QNR S1 RNA binding domain protein AUL54_05090 ENOG4108VPT UPF0234 protein AUL54_05105 ENOG4105MYW Pentapeptide repeat protein AUL54_05110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AUL54_05115 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AUL54_05120 ENOG4105SF0 DinB family AUL54_05125 ENOG4106HBX Transcriptional Regulator AraC Family AUL54_05130 ENOG4105UQX Mate efflux family protein AUL54_05140 ENOG4105CAQ asparagine synthetase AUL54_05155 ENOG4105ERH Fumarylacetoacetate hydrolase AUL54_05200 ENOG4105EYH Exonuclease AUL54_05210 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AUL54_05215 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AUL54_05220 ENOG4108QY0 Membrane AUL54_05230 ENOG4108IG5 Transcriptional regulator AUL54_05240 ENOG4108KK1 membrane protein AbrB duplication AUL54_05245 ENOG4108INS Transcriptional regulator AUL54_05250 ENOG4107SCK Monooxygenase AUL54_05265 ENOG41060YP AUL54_05270 ENOG4106CAD Protein of unknown function (DUF3311) AUL54_05275 ENOG4105E1V na solute symporter AUL54_05285 ENOG4105X3H Excalibur domain protein AUL54_05295 ENOG4108ZMX Domain of unknown function (DU1801) AUL54_05300 ENOG4105XVF Competence transcription factor AUL54_05320 ENOG4106YBV Methyl-accepting chemotaxis AUL54_05325 ENOG4107ZYJ bioY protein AUL54_05330 ENOG4107F3J Amp-dependent synthetase and ligase AUL54_05340 ENOG4107TB6 phosphoglycerate mutase AUL54_05345 ENOG4108HUF Transporter AUL54_05355 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AUL54_05365 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_05375 ENOG4105DF9 Lipoate-protein, ligase AUL54_05380 ENOG4108RQ5 Beta-lactamase domain-containing protein AUL54_05390 ENOG4105DER m42 family AUL54_05405 ENOG4105ECB domain protein AUL54_05415 ENOG4105C1Q protoporphyrinogen oxidase AUL54_05420 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AUL54_05425 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AUL54_05430 ENOG4105BZ4 penicillin-binding protein AUL54_05435 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AUL54_05465 ENOG4105K59 histidine triad (HIT) protein AUL54_05470 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AUL54_05475 ENOG4105NBU tryptophan transport protein AUL54_05515 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AUL54_05525 ENOG4105EQI Metal Dependent Phosphohydrolase AUL54_05530 ENOG4106D4I domain protein AUL54_05535 ENOG4107VRP DNA repair exonuclease AUL54_05540 ENOG4105RHA ABC transporter, permease AUL54_05545 ENOG4108IUX (ABC) transporter AUL54_05555 ENOG4105CGU Enoyl-CoA hydratase AUL54_05565 ENOG4105NCW Trka-c domain protein AUL54_05570 ENOG4107S91 Sodium hydrogen exchanger AUL54_05580 ENOG4105D4P Coproporphyrinogen iii oxidase AUL54_05590 ENOG4105F1N DNA alkylation repair AUL54_05595 ENOG4105WZB UPF0342 protein AUL54_05600 ENOG4106MP8 UPF0754 membrane protein AUL54_05610 ENOG410839P AUL54_05630 ENOG4105BZ1 (ABC) transporter AUL54_05635 ENOG4105BZ1 (ABC) transporter AUL54_05645 ENOG4105IIP Membrane AUL54_05650 ENOG4105W1N transcriptional regulator AUL54_05655 ENOG4105F0I Aminotransferase AUL54_05660 ENOG4107VMI polysaccharide deacetylase AUL54_05665 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AUL54_05670 ENOG4105D64 Mechanosensitive ion channel AUL54_05675 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AUL54_05680 ENOG4105WMR Protein CrcB homolog AUL54_05690 ENOG4105C37 (CBS) domain AUL54_05700 ENOG4105CHM Aminotransferase AUL54_05710 ENOG4105C37 (CBS) domain AUL54_05715 ENOG4105F6E Acyl-transferase AUL54_05720 ENOG4108AEY RNA polymerase sigma factor AUL54_05725 ENOG4105J37 AUL54_05740 ENOG4105C8J )-transporter AUL54_05745 ENOG4105CUB amino acid AUL54_05755 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AUL54_05760 ENOG4105BZN citrate synthase AUL54_05775 ENOG4105G6Z alkaline phosphatase AUL54_05780 ENOG4105ED1 spovr family AUL54_05820 ENOG4105BZU Histidine kinase AUL54_05830 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AUL54_05835 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AUL54_05845 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AUL54_05850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AUL54_05860 ENOG4107YBY Hydrolase AUL54_05865 ENOG41080XP Cbs domain AUL54_05875 ENOG4108YBP pseudouridine synthase AUL54_05915 ENOG4105BZU Histidine kinase AUL54_05920 ENOG4105VEQ Cold shock protein AUL54_05925 ENOG4108TU7 Inherit from COG: (ABC) transporter AUL54_05930 ENOG4105CJ1 ABC, transporter AUL54_05935 ENOG4105CZV ABC transporter AUL54_05940 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AUL54_05955 ENOG4105CS1 NAD(P)H quinone oxidoreductase AUL54_05960 ENOG4105C0R drug resistance transporter emrb qaca subfamily AUL54_05965 ENOG4105CW7 secretion protein, HlyD family AUL54_05970 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AUL54_05980 ENOG4105CYN Serine protein kinase AUL54_06000 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AUL54_06010 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AUL54_06025 ENOG4105VZ8 Transcriptional regulator AUL54_06030 ENOG4107D63 AUL54_06035 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AUL54_06050 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AUL54_06055 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AUL54_06060 ENOG4105E2Y ABC, transporter AUL54_06075 ENOG4108JQ7 (ABC) transporter AUL54_06080 ENOG4105C3U ABC transporter AUL54_06085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AUL54_06105 ENOG4105DNP FAD linked oxidase domain protein AUL54_06110 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AUL54_06115 ENOG4105EC3 peptidase S51, dipeptidase E AUL54_06245 ENOG4105TUA UPF0295 protein AUL54_06250 ENOG4105G5W regulator Fur family AUL54_06255 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AUL54_06260 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AUL54_06265 ENOG4107NBY Membrane AUL54_06270 ENOG4105BZ1 (ABC) transporter AUL54_06290 ENOG4105CAN Short-chain dehydrogenase reductase Sdr AUL54_06295 ENOG4106BXE AUL54_06300 ENOG4105CEN a g-specific adenine glycosylase AUL54_06305 ENOG410780I phosphoprotein phosphatase activity AUL54_06365 ENOG4108FKH Transglycosylase SLT domain AUL54_06405 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AUL54_06475 ENOG4105CDU Replicative dna helicase AUL54_06500 ENOG4108ZUE Phage regulatory protein rha AUL54_06535 ENOG4105VTR Integrase AUL54_06545 ENOG41067AE Membrane-bound metal-dependent hydrolase AUL54_06550 ENOG4105EJV Membrane AUL54_06555 ENOG4105CKK Glycosyl transferase, family 2 AUL54_06560 ENOG4105D74 hydrolase AUL54_06565 ENOG4106AKJ AUL54_06585 ENOG4105F27 Major Facilitator AUL54_06595 ENOG410902V Modulates RecA activity (By similarity) AUL54_06600 ENOG4105ECP epimerase AUL54_06610 ENOG4107Y03 Nitroreductase AUL54_06615 ENOG4105JAB phenazine biosynthesis protein, phzf family AUL54_06625 ENOG410834F Transcriptional regulator AUL54_06630 ENOG4105C0R drug resistance transporter emrb qaca subfamily AUL54_06635 ENOG4108YYS metal-dependent hydrolase (By similarity) AUL54_06650 ENOG4105H93 Acyltransferase family AUL54_06655 ENOG4105DYS nad(p)h dehydrogenase (quinone) AUL54_06660 ENOG4105U3E Transcriptional regulator AUL54_06665 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AUL54_06670 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AUL54_06680 ENOG4105BZ1 (ABC) transporter AUL54_06685 ENOG4105BZ1 (ABC) transporter AUL54_06695 ENOG4105CI1 PTS System AUL54_06700 ENOG4108Q3X Transcriptional regulator AUL54_06705 ENOG4105F8D glycoside hydrolase family 4 AUL54_06715 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AUL54_06725 ENOG4107QKR Dehydrogenase AUL54_06735 ENOG4107RUY (E1 component), alpha subunit AUL54_06755 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AUL54_06765 ENOG4105D7N magnesium and cobalt transport protein CorA AUL54_06775 ENOG4106KE4 Dehydrogenase AUL54_06795 ENOG4105D8X mechanosensitive ion channel AUL54_06805 ENOG4105UPD Calcium Proton AUL54_06810 ENOG4108ISG Major Facilitator AUL54_06815 ENOG4107U9T Pfam:Ribonuclease_BN AUL54_06825 ENOG4105KJF protein tyrosine phosphatase AUL54_06840 ENOG4105FF2 Type I DHQase AUL54_06845 ENOG4105E2X shikimate dehydrogenase AUL54_06850 ENOG4105ETE Transcriptional regulator (LacI family AUL54_06855 ENOG4107RKG DJ-1/PfpI family AUL54_06860 ENOG4105CGH 5'-nucleotidase AUL54_06875 ENOG4108RCM Nitroreductase AUL54_06915 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AUL54_06925 ENOG4108RPX mosc domain containing protein AUL54_06930 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) AUL54_06955 ENOG4108MRH transcriptional regulatory protein AUL54_06980 ENOG4107QPK )-transporter AUL54_06985 ENOG4108J20 pectate lyase AUL54_07000 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AUL54_07010 ENOG4105FDU atp-dependent rna helicase AUL54_07015 ENOG4105C5H ABC transporter AUL54_07020 ENOG4105DXB Major Facilitator superfamily AUL54_07025 ENOG4107SWG transcriptional regulator MERR family AUL54_07045 ENOG4105C5H ABC transporter AUL54_07050 ENOG4107TVC Glycosyl transferase, family 2 AUL54_07055 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AUL54_07060 ENOG4105FKZ Methyl-accepting chemotaxis AUL54_07065 ENOG4105C26 Dehydrogenase AUL54_07070 ENOG4105CUB amino acid AUL54_07075 ENOG4105EU0 Major facilitator Superfamily AUL54_07080 ENOG41090R9 glycosyltransferase AUL54_07085 ENOG4107R51 Glycosyl transferase, family 2 AUL54_07090 ENOG41090R9 glycosyltransferase AUL54_07100 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AUL54_07105 ENOG4105E0M Sulfatase AUL54_07110 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AUL54_07115 ENOG4108R1P AUL54_07120 ENOG41061H0 Monooxygenase AUL54_07125 ENOG41082F9 transcriptional regulator AUL54_07130 ENOG4106I4J membrane AUL54_07145 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AUL54_07150 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AUL54_07155 ENOG4105H67 Protein of unknown function (DUF421) AUL54_07165 ENOG4105M18 -acetyltransferase AUL54_07170 ENOG4105WEF catalase AUL54_07190 ENOG4105CDY transcriptional regulatory protein AUL54_07215 ENOG4105D9P serine threonine protein kinase AUL54_07225 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AUL54_07230 ENOG4105CBD Diacylglycerol kinase AUL54_07240 ENOG4108IG5 Transcriptional regulator AUL54_07245 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AUL54_07250 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AUL54_07255 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AUL54_07260 ENOG4105CK7 Sodium proline symporter AUL54_07265 ENOG4105KT7 mgtC SapB transporter AUL54_07270 ENOG4105CRN Aminoglycoside phosphotransferase AUL54_07280 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AUL54_07285 ENOG4105C4R Atp-dependent dna helicase AUL54_07295 ENOG4105CBC glutamate synthase AUL54_07300 ENOG4105KGF protein, YerC YecD AUL54_07305 ENOG4108R5T secreted protein AUL54_07320 ENOG4105C12 Phosphoribosylglycinamide synthetase AUL54_07325 ENOG4105DC1 bifunctional purine biosynthesis protein purh AUL54_07330 ENOG4108V3E phosphoribosylglycinamide formyltransferase AUL54_07335 ENOG4105CXB phosphoribosylaminoimidazole synthetase AUL54_07345 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii AUL54_07350 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AUL54_07355 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AUL54_07360 ENOG4105C8V SAICAR synthetase AUL54_07365 ENOG4105C83 adenylosuccinate lyase AUL54_07370 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AUL54_07375 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AUL54_07400 ENOG4105C7N Xanthine uracil vitamin C permease AUL54_07415 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AUL54_07430 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AUL54_07450 ENOG4106IBS oxygenase AUL54_07455 ENOG4105CPF Cell wall formation (By similarity) AUL54_07470 ENOG4105C5S asparaginyl-tRNA synthetase AUL54_07475 ENOG4105C85 amino acid AUL54_07480 ENOG4107STQ Multicopper oxidase AUL54_07505 ENOG4105JVQ RNA Polymerase AUL54_07510 ENOG4108P49 AntiSigma factor AUL54_07515 ENOG4105EXC Acyl-transferase AUL54_07525 ENOG4108WV1 Pfam:DUF477 AUL54_07530 ENOG4105DQX Zinc finger domain AUL54_07535 ENOG41087YS Phage shock protein A AUL54_07550 ENOG4105CT4 transporter AUL54_07555 ENOG4105CPQ Dehydrogenase AUL54_07560 ENOG4105PGZ NB-ARC domain AUL54_07575 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AUL54_07580 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AUL54_07585 ENOG4108TYN CAAX amino terminal protease family protein AUL54_07595 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AUL54_07600 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AUL54_07605 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AUL54_07610 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AUL54_07615 ENOG4105C5H ABC transporter AUL54_07620 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AUL54_07625 ENOG410801F ribosomal-protein-alanine acetyltransferase AUL54_07630 ENOG41072GX Peptidase M22 Glycoprotease AUL54_07635 ENOG4105K8N protein family UPF0079, ATPase AUL54_07640 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AUL54_07680 ENOG4107QNK )-transporter AUL54_07700 ENOG4107QTZ amino acid AUL54_07720 ENOG4105DJ2 Major Facilitator Superfamily AUL54_07725 ENOG4105JXH GntR family transcriptional regulator AUL54_07730 ENOG4108SUT Major Facilitator Superfamily AUL54_07735 ENOG41090UD (LipO)protein AUL54_07740 ENOG4105FQP Beta-lactamase AUL54_07760 ENOG4105DRR Transcriptional regulator, GntR family AUL54_07765 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AUL54_07770 ENOG4105EBM Alpha Beta Hydrolase Fold protein AUL54_07795 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AUL54_07800 ENOG4105C2C drug resistance transporter, Bcr CflA AUL54_07810 ENOG4108JYZ YitT family AUL54_07830 ENOG4105EYF MMPL domain protein AUL54_07835 ENOG4108VB1 regulatoR AUL54_07840 ENOG4105ENE Histidine kinase AUL54_07845 ENOG4108UW5 maltose o-acetyltransferase AUL54_07855 ENOG4106UW1 Major Facilitator superfamily AUL54_07865 ENOG4105PGS Spore coat protein AUL54_07870 ENOG4105E2A Dehydrogenase AUL54_07915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AUL54_07925 ENOG4105VUF Transcriptional regulator AUL54_07930 ENOG4105DQ4 alcohol dehydrogenase AUL54_07950 ENOG4108U7W acetyltransferase AUL54_07955 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein AUL54_07965 ENOG4105PGM cation diffusion facilitator family transporter AUL54_07975 ENOG4105DNP FAD linked oxidase domain protein AUL54_07990 ENOG41082W1 Cupin 2, conserved barrel domain protein AUL54_07995 ENOG4105IRW patatin-like phospholipase family protein AUL54_08000 ENOG4105DCM major facilitator superfamily AUL54_08005 ENOG410645S MarR family Transcriptional regulator AUL54_08025 ENOG4105CIH Imidazole acetol-phosphate transaminase AUL54_08030 ENOG4105CSH Transporter AUL54_08050 ENOG4105C0R drug resistance transporter emrb qaca subfamily AUL54_08055 ENOG4105DJ2 Major Facilitator Superfamily AUL54_08060 ENOG4108J2R molybdopterin oxidoreductase AUL54_08065 ENOG4105GZI Transcriptional regulator AUL54_08070 ENOG4108VJ1 Transcriptional regulator (CarD family AUL54_08075 ENOG4105VEQ Cold shock protein AUL54_08080 ENOG4108RYK Nad-dependent epimerase dehydratase AUL54_08085 ENOG4108Z40 Transcriptional regulator AUL54_08090 ENOG4108ZMQ domain protein AUL54_08100 ENOG4105K56 Transcriptional regulator AUL54_08130 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AUL54_08140 ENOG410847I Transcriptional regulator, BadM Rrf2 family AUL54_08145 ENOG4105I1F Resistance protein AUL54_08160 ENOG4107UNZ domain protein AUL54_08180 ENOG4105K4H Nlp p60 protein AUL54_08190 ENOG4105P1M Domain of unknown function (DUF1874) AUL54_08240 ENOG4106128 DNA-binding helix-turn-helix protein AUL54_08245 ENOG4106BHR ftsk SpoIIIE family protein AUL54_08250 ENOG4108RYM conjugative transposon protein AUL54_08270 ENOG4108IMY Transcriptional regulator AUL54_08275 ENOG41068WC Domain of unknown function (DUF955) AUL54_08280 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AUL54_08320 ENOG410906U SprT-like AUL54_08330 ENOG41064BQ Phosphatase AUL54_08340 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AUL54_08345 ENOG4105WN5 stage II sporulation protein AUL54_08350 ENOG4107SGM protein serine threonine phosphatase AUL54_08355 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase AUL54_08360 ENOG4105FUA antagonist AUL54_08365 ENOG4107MMM Anti-sigma-factor antagonist AUL54_08370 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AUL54_08380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AUL54_08385 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AUL54_08390 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AUL54_08400 ENOG4105CKV Membrane AUL54_08405 ENOG410905X membrane-flanked domain protein AUL54_08410 ENOG4105C1J atp-dependent rna helicase AUL54_08415 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AUL54_08420 ENOG4105CPF Cell wall formation (By similarity) AUL54_08425 ENOG4105SZ6 Thioredoxin AUL54_08440 ENOG4105FDT acyl-CoA dehydrogenase AUL54_08455 ENOG4105CJ1 ABC, transporter AUL54_08460 ENOG4106F5Q Membrane AUL54_08465 ENOG4107QJT sodium dicarboxylate symporter AUL54_08470 ENOG4108MRH transcriptional regulatory protein AUL54_08475 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AUL54_08480 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AUL54_08495 ENOG41082W1 Cupin 2, conserved barrel domain protein AUL54_08500 ENOG4105QVS general stress protein AUL54_08505 ENOG4105EU9 AUL54_08510 ENOG4105KPY Small multidrug resistance protein AUL54_08515 ENOG4105RXJ AUL54_08520 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) AUL54_08535 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AUL54_08580 ENOG4105C0X amino acid AUL54_08590 ENOG4107R8N Glycosyl transferase, family 2 AUL54_08595 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AUL54_08610 ENOG4105C9U ATP-dependent DNA helicase RecQ AUL54_08620 ENOG4105VCH membrane AUL54_08630 ENOG410606W general stress protein AUL54_08635 ENOG4108Z9I -acetyltransferase AUL54_08645 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AUL54_08655 ENOG4105ETD TRANSCRIPTIONal AUL54_08660 ENOG4107QM2 Aldo Keto reductase AUL54_08665 ENOG4107RVG penicillin-binding protein AUL54_08670 ENOG41061CK Antibiotic biosynthesis monooxygenase AUL54_08680 ENOG4105XJB lipolytic protein G-D-S-L family AUL54_08685 ENOG4107258 Transcriptional regulator AUL54_08695 ENOG4105P4J Allophanate hydrolase, subunit 1 AUL54_08700 ENOG4105CFM UPF0317 protein AUL54_08705 ENOG4105C5A transporter AUL54_08710 ENOG4105E7W lamb ycsf family protein AUL54_08725 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase AUL54_08745 ENOG4108ZYE Transcriptional regulator AUL54_08750 ENOG4108T5E Copper resistance protein AUL54_08755 ENOG4105KTB nuclear export factor GLE1 AUL54_08760 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AUL54_08770 ENOG4105C26 Dehydrogenase AUL54_08775 ENOG4108JPW Aminotransferase AUL54_08785 ENOG4105YVS arsR family transcriptional regulator AUL54_08790 ENOG41067V3 Antibiotic biosynthesis monooxygenase AUL54_08795 ENOG4108DBC nitroreductase AUL54_08800 ENOG4105R8C Transcriptional regulator AUL54_08815 ENOG4108IPW abc transporter atp-binding protein AUL54_08820 ENOG4105CM4 permease protein AUL54_08825 ENOG4105DHS permease protein AUL54_08830 ENOG4105CFH Aspartokinase AUL54_08845 ENOG4105BZU Histidine kinase AUL54_08850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AUL54_08855 ENOG4107WD8 ABC transporter, permease AUL54_08865 ENOG4108PGP mmge prpd family protein AUL54_08870 ENOG4105CH2 amidohydrolase AUL54_08880 ENOG4108HW4 amino acid AbC transporter AUL54_08885 ENOG4105EAB amino acid AbC transporter AUL54_08890 ENOG4108XSB acetyltransferase, (GNAT) family AUL54_08895 ENOG4105CPU Monooxygenase AUL54_08910 ENOG4105E1K spore germination protein AUL54_08925 ENOG4105DUX Transporter AUL54_08930 ENOG41069ZX AUL54_08935 ENOG41069ZX AUL54_08940 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AUL54_08945 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AUL54_08950 ENOG4106P55 Transcriptional regulator AUL54_08960 ENOG4105DRP amino acid AbC transporter AUL54_08965 ENOG4105CDA abc transporter atp-binding protein AUL54_08980 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AUL54_09000 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_09005 ENOG4105KVH Transcriptional regulator AUL54_09010 ENOG4108VA3 3-hexulose-6-phosphate synthase AUL54_09015 ENOG41080HJ 6-phospho 3-hexuloisomerase AUL54_09030 ENOG4105CS2 ec 3.2.1.21 AUL54_09040 ENOG4105HHM rdd domain containing protein AUL54_09045 ENOG4105E2A Dehydrogenase AUL54_09050 ENOG4105CKI cobalamin synthesis protein AUL54_09055 ENOG4108IFG nitrite reductase, (NAD(P)H) AUL54_09060 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AUL54_09065 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AUL54_09070 ENOG4105CAY ferredoxin--nadp reductase AUL54_09075 ENOG4107YHD transcriptional regulator AUL54_09080 ENOG4105CK7 Sodium proline symporter AUL54_09085 ENOG4105C26 Dehydrogenase AUL54_09095 ENOG410756H nucleotidyltransferase AUL54_09100 ENOG4105I82 acetyl xylan esterase AUL54_09105 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AUL54_09110 ENOG4105DJB Major Facilitator Superfamily AUL54_09125 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AUL54_09130 ENOG4105EIG urea carboxylase-associated protein 1 AUL54_09160 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AUL54_09195 ENOG4107SQ8 Glycine betaine AUL54_09200 ENOG4108IJ7 Glycine betaine AUL54_09205 ENOG41079KZ Major Facilitator Superfamily AUL54_09215 ENOG4108TTB tellurium resistance protein AUL54_09220 ENOG4107TS3 membrane protein, TerC AUL54_09225 ENOG4106FN3 tellurium resistance protein AUL54_09230 ENOG4106FN3 tellurium resistance protein AUL54_09235 ENOG4108N0M stress protein AUL54_09250 ENOG4105DIK (ABC) transporter AUL54_09255 ENOG4105DSE periplasmic solute binding protein AUL54_09270 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AUL54_09300 ENOG4107SET aldo keto reductase AUL54_09305 ENOG41060AI SEC-C motif AUL54_09310 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold AUL54_09315 ENOG4107RB3 L-asparaginase AUL54_09320 ENOG4105J7D transcriptional regulator AUL54_09325 ENOG4105C0R drug resistance transporter emrb qaca subfamily AUL54_09330 ENOG4107EPV Aminotransferase class V AUL54_09335 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AUL54_09340 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AUL54_09345 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AUL54_09350 ENOG4105DGI Alkaline phosphatase AUL54_09365 ENOG4105XXY Thioredoxin AUL54_09370 ENOG4108VGI doxx family AUL54_09375 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AUL54_09380 ENOG4108TVJ Nitroreductase AUL54_09385 ENOG41076HS cation diffusion facilitator family transporter AUL54_09400 ENOG4105CSV Glutaminase AUL54_09410 ENOG4108J5H Homocysteine s-methyltransferase AUL54_09415 ENOG4108IQI permease AUL54_09420 ENOG4105CM2 brancheD-chain amino acid aminotransferase AUL54_09430 ENOG4105C72 UPF0176 protein AUL54_09445 ENOG4107ZTW SNARE associated Golgi AUL54_09450 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AUL54_09455 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AUL54_09460 ENOG4107SCQ Iron-containing alcohol dehydrogenase AUL54_09470 ENOG4106BHF AUL54_09500 ENOG4105CXY transporter AUL54_09505 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AUL54_09520 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) AUL54_09525 ENOG4107QTZ amino acid AUL54_09540 ENOG4106DDH Sporulation-specific SASP protein AUL54_09555 ENOG41090VJ ABC-2 type transporter AUL54_09565 ENOG4105CJ1 ABC, transporter AUL54_09570 ENOG4105WH1 Two component transcriptional regulator luxr family AUL54_09575 ENOG4105BZU Histidine kinase AUL54_09590 ENOG41061AU MarR family Transcriptional regulator AUL54_09600 ENOG41067MG lrgb family AUL54_09610 ENOG4106K80 AUL54_09625 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AUL54_09635 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AUL54_09640 ENOG4107U5W ybbr family AUL54_09645 ENOG4105C8B TIGR00159 family AUL54_09655 ENOG4105EMN RNA polymerase sigma factor AUL54_09685 ENOG4105EWC Purine nucleoside phosphorylase AUL54_09695 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AUL54_09710 ENOG4105D17 glycoside hydrolase, family 3 domain protein AUL54_09715 ENOG4105EHZ conserved protein UCP016719 AUL54_09720 ENOG410874W AraC family transcriptional regulator AUL54_09740 ENOG4108SA1 esterase AUL54_09750 ENOG4105CHH sulfate transporter AUL54_09755 ENOG4105CPQ Dehydrogenase AUL54_09765 ENOG4108JPW Aminotransferase AUL54_09830 ENOG4108NMV polysaccharide deacetylase AUL54_09845 ENOG4105D1F ATP-binding protein AUL54_09865 ENOG4108I0C methyltransferase AUL54_09870 ENOG4108UJD 30S ribosomal protein S9 AUL54_09875 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AUL54_09880 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AUL54_09885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AUL54_09890 ENOG4108JJB ABC transporter AUL54_09895 ENOG4108JJB ABC transporter AUL54_09900 ENOG4108ZT0 50S ribosomal protein l17 AUL54_09905 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AUL54_09910 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AUL54_09915 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AUL54_09925 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AUL54_09930 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AUL54_09935 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AUL54_09940 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AUL54_09945 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AUL54_09950 ENOG4105VPB 50S ribosomal protein L30 AUL54_09955 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AUL54_09960 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AUL54_09965 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AUL54_09970 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AUL54_09975 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AUL54_09990 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AUL54_09995 ENOG41082SA 50s ribosomal protein l29 AUL54_10000 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AUL54_10005 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AUL54_10010 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AUL54_10015 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AUL54_10020 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AUL54_10025 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AUL54_10030 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AUL54_10035 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AUL54_10040 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AUL54_10045 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AUL54_10050 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AUL54_10055 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AUL54_10060 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AUL54_10065 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AUL54_10070 ENOG4105XPM ribosomal protein AUL54_10075 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AUL54_10080 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AUL54_10085 ENOG4107Y49 methyltransferase AUL54_10090 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AUL54_10095 ENOG4108VZM 50s ribosomal protein L10 AUL54_10105 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AUL54_10110 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AUL54_10130 ENOG4105M0M Tetracycline resistance protein AUL54_10135 ENOG4105C2N RNA methyltransferase TrmH family group 3 AUL54_10140 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) AUL54_10150 ENOG4105D7W serine acetyltransferase AUL54_10155 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AUL54_10160 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AUL54_10165 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AUL54_10170 ENOG4105CTP PilT protein domain protein AUL54_10175 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) AUL54_10180 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AUL54_10190 ENOG41066A3 ATP guanido phosphotransferase AUL54_10195 ENOG4108Z0C Uvrb UvrC protein AUL54_10280 ENOG4105CRK lysyL-tRNA synthetase AUL54_10285 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AUL54_10295 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AUL54_10300 ENOG4105KRF dihydroneopterin aldolase AUL54_10305 ENOG4105EEI dihydropteroate synthase AUL54_10310 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AUL54_10315 ENOG4105DDQ anthranilate synthase AUL54_10320 ENOG4105CRQ synthase (Component I) AUL54_10325 ENOG4105C6T cysteine synthase AUL54_10330 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase AUL54_10335 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AUL54_10340 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) AUL54_10345 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AUL54_10350 ENOG4108UGV hypoxanthine phosphoribosyltransferase AUL54_10355 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AUL54_10385 ENOG41060GV RNA binding s1 domain protein AUL54_10400 ENOG4105VYY sporulation protein yabp AUL54_10405 ENOG41082I2 s4 domain protein AUL54_10410 ENOG4108IY2 MazG family AUL54_10420 ENOG4108M14 stage v sporulation protein t AUL54_10425 ENOG4108JA2 transcriptioN-repair coupling factor AUL54_10440 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AUL54_10445 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AUL54_10450 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AUL54_10455 ENOG4105K4W Could be involved in septation (By similarity) AUL54_10460 ENOG4105KME endoribonuclease L-psp AUL54_10465 ENOG4105DFT pur operon repressor AUL54_10470 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AUL54_10475 ENOG4105XEW small acid-soluble spore protein AUL54_10480 ENOG4105W42 Veg protein AUL54_10485 ENOG4105XFA sporulation peptidase YabG AUL54_10490 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AUL54_10500 ENOG41069ER domain protein AUL54_10505 ENOG4105F8V Hydrolase, tatD family AUL54_10510 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AUL54_10515 ENOG4105KRN Transcriptional regulator, abrb family AUL54_10520 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AUL54_10525 ENOG4105VC4 domain protein AUL54_10530 ENOG41060K3 Methyltransferase AUL54_10540 ENOG4105MA4 psp1 domain protein AUL54_10545 ENOG4105FA2 dna polymerase iii AUL54_10550 ENOG4105XVJ Protein of unknown function (DUF327) AUL54_10555 ENOG4105X0R protein from nitrogen regulatory protein P-II AUL54_10560 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AUL54_10565 ENOG4105CXN decarboxylase AUL54_10570 ENOG4105CDW Resistance protein AUL54_10610 ENOG41067KS pro-sigma K processing AUL54_10620 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AUL54_10625 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AUL54_10630 ENOG4105C6E dna polymerase iii AUL54_10645 ENOG4108Z6B deaminase AUL54_10650 ENOG4105GTG Isochorismatase AUL54_10655 ENOG4105VRS hydrolase family 18 AUL54_10665 ENOG4105ZMH deoxynucleoside kinase AUL54_10680 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AUL54_10685 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AUL54_10690 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AUL54_10700 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AUL54_10735 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AUL54_10740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AUL54_10750 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AUL54_10755 ENOG410848D S4 domain protein YaaA AUL54_10760 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AUL54_10765 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AUL54_10770 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AUL54_10785 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AUL54_10790 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AUL54_10805 ENOG4107QJE Chromosome Partitioning Protein AUL54_10810 ENOG4105FA0 parb-like partition protein AUL54_10815 ENOG4108ZDA Sporulation protein YyaC AUL54_10830 ENOG4105VDK protein, conserved in bacteria AUL54_10835 ENOG4108J2R molybdopterin oxidoreductase AUL54_10840 ENOG4105C3G gtp-binding protein AUL54_10845 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AUL54_10850 ENOG4108UUM single-stranded DNA-binding protein AUL54_10855 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AUL54_10865 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AUL54_10870 ENOG4105CGK Exodeoxyribonuclease III AUL54_10880 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AUL54_10890 ENOG4107FCW Abortive infection protein AUL54_10895 ENOG4105C7Z Conserved Protein AUL54_10900 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AUL54_10910 ENOG4108RDQ ABC transporter AUL54_10945 ENOG4107Y9U Membrane AUL54_10955 ENOG41082BV acetyltransferase AUL54_10960 ENOG4108U05 Transcriptional regulator AUL54_10970 ENOG4105FS7 Transcriptional regulator AUL54_10975 ENOG4108TVJ Nitroreductase AUL54_10985 ENOG4107RSM transcriptional regulator AUL54_11000 ENOG4108WYP Transcriptional regulator AUL54_11005 ENOG4108HKT sucrose-6-phosphate hydrolase AUL54_11010 ENOG4105EDQ levansucrase EC 2.4.1.10 AUL54_11015 ENOG4108UZ3 Transporter AUL54_11020 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AUL54_11025 ENOG4105KVH Transcriptional regulator AUL54_11035 ENOG4108XMW Membrane AUL54_11040 ENOG4105BZR domain protein AUL54_11060 ENOG4105CPK Glycosyl transferase (Group 1 AUL54_11065 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AUL54_11075 ENOG4105JNK Glycosyl transferase (Group 1 AUL54_11090 ENOG4105CDU Replicative dna helicase AUL54_11095 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AUL54_11100 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AUL54_11130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AUL54_11135 ENOG4105BZU Histidine kinase AUL54_11150 ENOG4105Q2H domain protein AUL54_11155 ENOG4105C0H protease AUL54_11170 ENOG4108JUB Transcriptional regulator AUL54_11175 ENOG41082BM Transcriptional regulator, arsr family AUL54_11185 ENOG4105C8Y Acetylornithine aminotransferase AUL54_11190 ENOG4108IQI permease AUL54_11195 ENOG41066UZ arginase EC 3.5.3.1 AUL54_11205 ENOG4105WQG acetyltransferase AUL54_11210 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) AUL54_11225 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AUL54_11230 ENOG4105D9P serine threonine protein kinase AUL54_11265 ENOG4105XRQ Xanthine dehydrogenase accessory factor AUL54_11285 ENOG4108XHQ (2Fe-2S)-binding domain protein AUL54_11290 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 AUL54_11295 ENOG4105C85 amino acid AUL54_11300 ENOG4108JU3 Alkyl hydroperoxide reductase AUL54_11305 ENOG4105D3R alkyl hydroperoxide reductase AUL54_11315 ENOG41085PJ rdd domain containing protein AUL54_11320 ENOG4105F27 Major Facilitator AUL54_11325 ENOG4105WAB arsR family transcriptional regulator AUL54_11335 ENOG4108ITS PQQ enzyme repeat AUL54_11340 ENOG4105C26 Dehydrogenase AUL54_11345 ENOG4105ST3 Transcriptional regulator AUL54_11350 ENOG4105ECK Fatty Acid Desaturase AUL54_11355 ENOG4108ZGX Histidine kinase AUL54_11360 ENOG4108S01 response regulator AUL54_11365 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AUL54_11375 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AUL54_11380 ENOG4107QNK )-transporter AUL54_11385 ENOG4105CPC Aldo Keto reductase AUL54_11395 ENOG4105C26 Dehydrogenase AUL54_11405 ENOG4105EDK PfkB domain protein AUL54_11415 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AUL54_11420 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AUL54_11425 ENOG4105F0H myo-inositol catabolism protein AUL54_11430 ENOG4105WZ4 isomerase AUL54_11435 ENOG4105D2N Aldolase AUL54_11465 ENOG4108V5C ABC transporter AUL54_11495 ENOG410667J hydrolase AUL54_11500 ENOG4107RHR regulatoR AUL54_11505 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AUL54_11510 ENOG4105D9N nucleoside AUL54_11515 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AUL54_11535 ENOG4105C5Y PTS System AUL54_11540 ENOG4105CS2 ec 3.2.1.21 AUL54_11545 ENOG4107YZX Universal stress protein AUL54_11555 ENOG4108NR7 pectate lyase AUL54_11560 ENOG4105CNA YD repeat protein AUL54_11640 ENOG4105C1J atp-dependent rna helicase AUL54_11645 ENOG4105DEU major facilitator superfamily AUL54_11650 ENOG4105CID antiterminator AUL54_11660 ENOG4105D4T Citrate transporter AUL54_11665 ENOG4105CH6 catalase AUL54_11685 ENOG4105DHI Methyltransferase AUL54_11700 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AUL54_11705 ENOG4105CMR udp-glucose 4-epimerase AUL54_11715 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AUL54_11730 ENOG4107BJW polysaccharide deacetylase AUL54_11735 ENOG4105D2K citrate carrier protein AUL54_11740 ENOG4105C4M (Ubiquinol oxidase) subunit I AUL54_11745 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AUL54_11750 ENOG4108JJ9 ABC, transporter AUL54_11755 ENOG4108JJ8 (ABC) transporter AUL54_11760 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AUL54_11765 ENOG4105ETS cytosine purines uracil thiamine allantoin AUL54_11770 ENOG4107QHE Choloylglycine hydrolase AUL54_11775 ENOG4105CH6 catalase AUL54_11780 ENOG4107R5R arsenical pump membrane protein AUL54_11785 ENOG41082YX Transcriptional regulator, arsr family AUL54_11790 ENOG4108V5C ABC transporter AUL54_11795 ENOG4105EHG Permease protein AUL54_11800 ENOG4105DQ5 transport system permease protein AUL54_11810 ENOG4105EMD TRANSCRIPTIONal AUL54_11815 ENOG4105VZJ PTS System AUL54_11820 ENOG4105CK1 PTS System AUL54_11825 ENOG4105VCP PTS System AUL54_11830 ENOG4105F8D glycoside hydrolase family 4 AUL54_11855 ENOG4105C26 Dehydrogenase AUL54_11865 ENOG4105CM2 brancheD-chain amino acid aminotransferase AUL54_11870 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AUL54_11875 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) AUL54_11880 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AUL54_11885 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) AUL54_11895 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AUL54_11905 ENOG4105X1N Glycosyl transferase family 8 AUL54_11910 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin AUL54_11915 ENOG4105CK1 PTS System AUL54_11925 ENOG4105DR4 Methyltransferase AUL54_11935 ENOG41067MG lrgb family AUL54_11940 ENOG4105VAW lrga family AUL54_11945 ENOG4105CMU LysR family (Transcriptional regulator AUL54_11950 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AUL54_11955 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AUL54_11960 ENOG4107SJW iron permease, FTR1 AUL54_11965 ENOG410650H (LipO)protein AUL54_11970 ENOG4105DBE peroxidase AUL54_11975 ENOG4107ZXU DSBA oxidoreductase AUL54_11985 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AUL54_12000 ENOG4105WH5 Teichoic acid glycosylation protein AUL54_12005 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AUL54_12015 ENOG4107BMA Transglycosylase associated protein AUL54_12020 ENOG4105E2S oxidase) subunit II AUL54_12025 ENOG4105BZ9 Cytochrome C oxidase, subunit I AUL54_12045 ENOG4105I4A GCN5-related N-acetyltransferase AUL54_12055 ENOG4108DBC nitroreductase AUL54_12065 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AUL54_12080 ENOG4105C5Y PTS System AUL54_12095 ENOG4105DWF phosphomethylpyrimidine kinase AUL54_12115 ENOG4108RJ9 Glycosyl transferase, family 2 AUL54_12120 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AUL54_12155 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AUL54_12160 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD AUL54_12170 ENOG4107TY6 Acylneuraminate cytidylyltransferase AUL54_12175 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG AUL54_12180 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AUL54_12185 ENOG4105C1B dTDP-glucose 4-6-dehydratase AUL54_12190 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AUL54_12195 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase AUL54_12200 ENOG4105D82 Glutamate dehydrogenase AUL54_12205 ENOG4105C26 Dehydrogenase AUL54_12220 ENOG4105C2C drug resistance transporter, Bcr CflA AUL54_12225 ENOG4105FCW Major Facilitator superfamily AUL54_12255 ENOG4105CHM Aminotransferase AUL54_12265 ENOG4107JTW chlorite dismutase AUL54_12270 ENOG4108IJ2 phosphate acetyltransferase AUL54_12275 ENOG4105HMI Membrane AUL54_12280 ENOG4105DUM transcriptional regulator, lysR family AUL54_12285 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AUL54_12310 ENOG4108TU7 Inherit from COG: (ABC) transporter AUL54_12315 ENOG4105CJ1 ABC, transporter AUL54_12325 ENOG4105K7K Transcriptional regulator AUL54_12330 ENOG4108VCI transcription factor, rsfa family AUL54_12340 ENOG4105DCI Phosphohydrolase AUL54_12350 ENOG4105CUB amino acid AUL54_12355 ENOG41067TZ transcriptional regulator, MarR family AUL54_12360 ENOG41069HH 4-oxalocrotonate tautomerase AUL54_12365 ENOG4108Z4T Peptidase M50 AUL54_12370 ENOG4108XFG YwhD family AUL54_12380 ENOG4105BZ4 penicillin-binding protein AUL54_12385 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AUL54_12390 ENOG4105CYW agmatinase AUL54_12395 ENOG4107JM4 Tetratricopeptide repeat AUL54_12400 ENOG410684U Domain of unknown function (DUF1934) AUL54_12405 ENOG4105C75 arginyL-tRNA synthetase AUL54_12415 ENOG4107V6Q Cyclic nucleotide-binding domain AUL54_12435 ENOG4108IUE nitrate reductase beta subunit AUL54_12440 ENOG4105R3A Nitrate reductase AUL54_12455 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AUL54_12460 ENOG4105BZ1 (ABC) transporter AUL54_12470 ENOG4105E5J UV damage endonuclease AUL54_12480 ENOG4105DF6 Fe-S oxidoreductase AUL54_12490 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AUL54_12500 ENOG410812K response regulator receiver protein AUL54_12505 ENOG4105D2N Aldolase AUL54_12515 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AUL54_12520 ENOG4105CBT Fructose-1,6-bisphosphatase AUL54_12530 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AUL54_12535 ENOG41082DI 50s ribosomal protein l31 AUL54_12540 ENOG4107104 thymidine kinase AUL54_12545 ENOG4105C6K Malic enzyme AUL54_12550 ENOG4107TT2 Auxin Efflux Carrier AUL54_12560 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AUL54_12565 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AUL54_12570 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AUL54_12585 ENOG4108ZXQ stage ii sporulation protein r AUL54_12595 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AUL54_12600 ENOG410815N Probably functions as a manganese efflux pump (By similarity) AUL54_12605 ENOG4107WAU Protein tyrosine phosphatase AUL54_12610 ENOG4108YZG isomerase AUL54_12615 ENOG4108UIC UPF0340 protein AUL54_12620 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AUL54_12625 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AUL54_12635 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AUL54_12650 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AUL54_12655 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AUL54_12660 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AUL54_12665 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AUL54_12670 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AUL54_12680 ENOG4106778 Protein of unknown function (DUF1146) AUL54_12690 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AUL54_12705 ENOG4108TF4 von Willebrand factor, type A AUL54_12710 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AUL54_12715 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AUL54_12735 ENOG4108YZ9 Urea amidohydrolase subunit gamma AUL54_12740 ENOG4105KI2 Urea amidohydrolase subunit beta AUL54_12745 ENOG4105CQM Urea amidohydrolase subunit alpha AUL54_12750 ENOG4108Z40 Transcriptional regulator AUL54_12755 ENOG4107T94 Endo-14-beta-xylanase AUL54_12760 ENOG4106BRK AUL54_12765 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AUL54_12780 ENOG4107TCE N-acetyltransferase AUL54_12785 ENOG4105FRN stage II sporulation protein AUL54_12795 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AUL54_12800 ENOG4105CNI cell division protein FtsW AUL54_12810 ENOG4105BZU Histidine kinase AUL54_12815 ENOG4105D3W isochorismatase AUL54_12820 ENOG41080V3 Major Facilitator superfamily AUL54_12825 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AUL54_12830 ENOG4105CZM Major Facilitator AUL54_12835 ENOG4107MII Sugar-specific transcriptional regulator TrmB AUL54_12840 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AUL54_12845 ENOG4105DFF Rod shape-determining protein mreb AUL54_12855 ENOG4105CGA flagellar basal-body rod protein FlgG AUL54_12865 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AUL54_12870 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AUL54_12890 ENOG4105E98 transcriptional regulator DeoR family AUL54_12895 ENOG410667J hydrolase AUL54_12900 ENOG4105C0D helicase AUL54_12905 ENOG4105KBK Zinc finger, swim domain protein AUL54_12915 ENOG4105HTX biosynthesis protein AUL54_12920 ENOG4107YJ4 chain length determinant protein AUL54_12925 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AUL54_12930 ENOG4105C6Y Udp-glucose 6-dehydrogenase AUL54_12965 ENOG4105FGV Chromate AUL54_12970 ENOG4105CAH Chromate AUL54_12980 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AUL54_12990 ENOG4107XC4 flavin reductase domain protein, FMN-binding AUL54_13005 ENOG4106UIA AUL54_13020 ENOG4107RSM transcriptional regulator AUL54_13030 ENOG4107FQX Alpha-acetolactate decarboxylase AUL54_13035 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AUL54_13045 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AUL54_13050 ENOG4105CNN ABC, transporter AUL54_13055 ENOG4105C2J ABC transporter AUL54_13060 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AUL54_13065 ENOG4108RVA ribokinase AUL54_13070 ENOG4105ETE Transcriptional regulator (LacI family AUL54_13080 ENOG4105N98 Capsule biosynthesis protein capB AUL54_13090 ENOG4105PNM synthesis protein AUL54_13095 ENOG4105K4H Nlp p60 protein AUL54_13100 ENOG4106UBQ AUL54_13105 ENOG4105J7I hydrolase AUL54_13110 ENOG4108KGH TRANSCRIPTIONal AUL54_13115 ENOG4105C54 Major Facilitator superfamily AUL54_13120 ENOG4105K64 Glycosyl transferase, family 2 AUL54_13125 ENOG4108NHD germination protein AUL54_13140 ENOG4105DG6 mannose-6-phosphate isomerase AUL54_13150 ENOG4107RZX Teichoic acid biosynthesis protein AUL54_13160 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase AUL54_13170 ENOG4107SJB teichoic acid biosynthesis AUL54_13180 ENOG4105EY8 ABC transporter AUL54_13185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AUL54_13190 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AUL54_13205 ENOG4105JFG SpoIID LytB domain protein AUL54_13210 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AUL54_13215 ENOG4105D3Q Sugar transferase AUL54_13220 ENOG4105PSV Polysaccharide Biosynthesis Protein AUL54_13225 ENOG4107RA4 Glycosyl transferase (Group 1 AUL54_13230 ENOG4105C6Y Udp-glucose 6-dehydrogenase AUL54_13235 ENOG4105QZI O-Antigen Polymerase AUL54_13250 ENOG4107EF8 Glycosyl transferase (Group 1 AUL54_13255 ENOG4105ESV Glycosyl transferase, family 4 AUL54_13260 ENOG4108KGH TRANSCRIPTIONal AUL54_13265 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AUL54_13270 ENOG4105BZU Histidine kinase AUL54_13275 ENOG4105WH1 Two component transcriptional regulator luxr family AUL54_13295 ENOG41081UC Inherit from COG: Competence protein AUL54_13300 ENOG4105RU3 AUL54_13315 ENOG4105E1Q flagellar hook-associated protein AUL54_13320 ENOG4105DTJ flagellar hook-associated protein AUL54_13330 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AUL54_13335 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AUL54_13340 ENOG4105I03 Flagellin AUL54_13345 ENOG4107RT6 flagellar hook-associated AUL54_13350 ENOG4105MQ3 flagellar protein FliS AUL54_13365 ENOG4105MS2 ribosomal subunit Interface protein AUL54_13370 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AUL54_13375 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AUL54_13390 ENOG4105CAK Cell division ATP-binding protein ftsE AUL54_13395 ENOG4105CRP Part of the ABC transporter FtsEX involved in AUL54_13400 ENOG4108M26 parallel beta-helix repeat protein AUL54_13405 ENOG4105CN1 protease AUL54_13430 ENOG4105MKU Transcriptional regulator AUL54_13445 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AUL54_13450 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AUL54_13465 ENOG4108PY7 AUL54_13470 ENOG41067S9 phage shock protein C, PspC AUL54_13475 ENOG41086DT Membrane protein of unknown function AUL54_13480 ENOG41088CQ domain protein AUL54_13485 ENOG4105J7D transcriptional regulator AUL54_13490 ENOG4105FDP GntR family transcriptional regulator AUL54_13495 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AUL54_13500 ENOG4105CE4 GlcNAc 6-P deacetylase AUL54_13505 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AUL54_13515 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AUL54_13520 ENOG4108S4C acetyltransferase AUL54_13530 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AUL54_13535 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AUL54_13540 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AUL54_13545 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AUL54_13550 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AUL54_13555 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AUL54_13560 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AUL54_13565 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AUL54_13570 ENOG4105BZ1 (ABC) transporter AUL54_13575 ENOG4105GIG AUL54_13580 ENOG4105EFI regulatoR AUL54_13585 ENOG4105BZU Histidine kinase AUL54_13605 ENOG4105C3M thioredoxin reductase AUL54_13610 ENOG4108Z4K mutator MutT protein AUL54_13615 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AUL54_13620 ENOG4105CHW UPF0052 protein AUL54_13625 ENOG4105CIE May be required for sporulation (By similarity) AUL54_13630 ENOG4105KRI phosphocarrier protein (HPr AUL54_13635 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AUL54_13640 ENOG4105GGE ribonuclease AUL54_13645 ENOG4105C5I Dehydrogenase AUL54_13650 ENOG4108V2W Carbonate dehydratase AUL54_13655 ENOG4105CHH sulfate transporter AUL54_13660 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain AUL54_13665 ENOG4108URH decarboxylase AUL54_13680 ENOG4105C7F AcnD-accessory protein PrpF AUL54_13685 ENOG4108KAM Transcriptional regulator AUL54_13690 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AUL54_13695 ENOG4105ETE Transcriptional regulator (LacI family AUL54_13705 ENOG4108HKT sucrose-6-phosphate hydrolase AUL54_13765 ENOG4105PY6 Phenolic acid decarboxylase AUL54_13770 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AUL54_13780 ENOG4105NAE bifunctional deaminase-reductase domain protein AUL54_13790 ENOG4105EBR Carboxylesterase AUL54_13800 ENOG4105HTX biosynthesis protein AUL54_13805 ENOG4108QV3 biosynthesis protein AUL54_13815 ENOG4108PQP glycosyl transferase group 1 AUL54_13820 ENOG4105K64 Glycosyl transferase, family 2 AUL54_13825 ENOG4108KMV Glycosyl transferase (Group 1 AUL54_13830 ENOG41068W6 Capsular polysaccharide biosynthesis protein AUL54_13835 ENOG4107QRS glycosyltransferase group 2 family protein AUL54_13845 ENOG4105K64 Glycosyl transferase, family 2 AUL54_13855 ENOG4105D3Q Sugar transferase AUL54_13860 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family AUL54_13865 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AUL54_13870 ENOG4108ZPC Polysaccharide pyruvyl transferase AUL54_13880 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AUL54_13885 ENOG4105DAA L-lactate AUL54_13890 ENOG4105JXH GntR family transcriptional regulator AUL54_13895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AUL54_13900 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AUL54_13905 ENOG4107QR9 Iron-sulfur cluster binding protein AUL54_13915 ENOG4105C6Z Gluconate AUL54_13920 ENOG4105CMG Carbohydrate kinase AUL54_13925 ENOG4106KNT transcriptional regulator AUL54_13940 ENOG4105DQ6 Transposase AUL54_13945 ENOG4107RT3 EamA-like transporter family AUL54_13950 ENOG4105GZI Transcriptional regulator AUL54_13960 ENOG4105DEN Luciferase family AUL54_13965 ENOG4105CMD Transcriptional regulator, GntR family AUL54_13980 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AUL54_13985 ENOG4105BZA Phosphoglycerate kinase AUL54_13990 ENOG4105CP7 Triose-phosphate isomerase AUL54_13995 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AUL54_14000 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AUL54_14005 ENOG4108W0I acetyltransferase AUL54_14010 ENOG4105T65 Membrane-associated protein AUL54_14025 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AUL54_14030 ENOG4107HG4 Transcriptional regulator AUL54_14035 ENOG4108IJ8 ABC transporter AUL54_14040 ENOG4105E90 ABC transporter AUL54_14045 ENOG4108HQR Glycine betaine AUL54_14050 ENOG4105R40 Glycine betaine carnitine choline AUL54_14055 ENOG4107HG4 Transcriptional regulator AUL54_14060 ENOG4108IJ8 ABC transporter AUL54_14070 ENOG4108HQR Glycine betaine AUL54_14075 ENOG4105R40 Glycine betaine carnitine choline AUL54_14080 ENOG4105DA5 (ABC) transporter AUL54_14105 ENOG4105KVH Transcriptional regulator AUL54_14125 ENOG4105XZU Preprotein translocase, subunit SecG AUL54_14135 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AUL54_14140 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AUL54_14170 ENOG41067XF inhibitor AUL54_14175 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AUL54_14180 ENOG4108KSA LysR family transcriptional regulator AUL54_14185 ENOG4108XSB acetyltransferase, (GNAT) family AUL54_14210 ENOG4105CDA abc transporter atp-binding protein AUL54_14215 ENOG4105DEN Luciferase family AUL54_14250 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AUL54_14255 ENOG4105D9R oxidoreductase AUL54_14260 ENOG4105VPX protein, conserved in bacteria AUL54_14265 ENOG410681U heavy metal transport detoxification protein AUL54_14270 ENOG4105C59 p-type ATPase AUL54_14275 ENOG4105C59 p-type ATPase AUL54_14280 ENOG4107ZQN disulfide bond AUL54_14295 ENOG4105EN6 Membrane AUL54_14300 ENOG4105EEM helicase AUL54_14305 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AUL54_14310 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AUL54_14315 ENOG4105EEQ Na H antiporter AUL54_14330 ENOG4108KYE ABC-2 type transporter AUL54_14340 ENOG4105CJ1 ABC, transporter AUL54_14345 ENOG4105BZU Histidine kinase AUL54_14350 ENOG4105WH1 Two component transcriptional regulator luxr family AUL54_14355 ENOG4105E0C molybdate abc transporter AUL54_14360 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AUL54_14365 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AUL54_14370 ENOG4107QZ2 Sulfatase AUL54_14375 ENOG4107K5X Membrane-bound metal-dependent hydrolase AUL54_14385 ENOG4105D5Q Arginine ornithine antiporter AUL54_14390 ENOG4105JQZ Methyltransferase AUL54_14400 ENOG4105DQ5 transport system permease protein AUL54_14405 ENOG4105EHG Permease protein AUL54_14410 ENOG4105E0A ABC, transporter AUL54_14420 ENOG4105F0F Oxalate decarboxylase AUL54_14425 ENOG4106DF4 Sigma-70, region 4 AUL54_14435 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AUL54_14445 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AUL54_14450 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AUL54_14455 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AUL54_14460 ENOG4105EHG Permease protein AUL54_14465 ENOG4105E0A ABC, transporter AUL54_14470 ENOG4108WBT adenosyltransferase AUL54_14485 ENOG41087YS Phage shock protein A AUL54_14500 ENOG4105ENE Histidine kinase AUL54_14505 ENOG4105WH1 Two component transcriptional regulator luxr family AUL54_14530 ENOG4105C9Q fumarate hydratase class II AUL54_14535 ENOG41067SE Tetr family transcriptional regulator AUL54_14540 ENOG4105F3H Histidine kinase AUL54_14550 ENOG4105C0H protease AUL54_14555 ENOG4105HUF DNA protection during starvation protein AUL54_14560 ENOG4105E1F short-chain dehydrogenase reductase AUL54_14575 ENOG4105E0A ABC, transporter AUL54_14595 ENOG4105MDS 4-oxalocrotonate tautomerase AUL54_14600 ENOG4105C0R drug resistance transporter emrb qaca subfamily AUL54_14605 ENOG41067TZ transcriptional regulator, MarR family AUL54_14635 ENOG4105CHU acetyl-coa acetyltransferase AUL54_14640 ENOG4105C1G acyl-Coa dehydrogenase AUL54_14645 ENOG41080E8 Transcriptional regulator, Spx MgsR family AUL54_14650 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AUL54_14675 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AUL54_14680 ENOG4108UMI ABC transporter, permease AUL54_14685 ENOG4105D01 (LipO)protein AUL54_14695 ENOG4105C3K feS assembly ATPase SufC AUL54_14700 ENOG4105JRK feS assembly protein SufD AUL54_14705 ENOG4105C9B Cysteine desulfurase AUL54_14710 ENOG4108UNV SUF system FeS assembly protein, NifU family AUL54_14715 ENOG4105DIW FeS assembly protein SUFB AUL54_14750 ENOG41090VF Stage v sporulation protein ac AUL54_14755 ENOG4105CZ3 stage V sporulation protein ad AUL54_14770 ENOG4108QY0 Membrane AUL54_14775 ENOG4106BHF AUL54_14800 ENOG4107VFR oxidoreductase AUL54_14805 ENOG4105PKS Excinuclease abc c subunit domain protein AUL54_14830 ENOG4108Z6Z Transcriptional regulator AUL54_14835 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine AUL54_14840 ENOG4105XN3 extracellular solute-binding protein family 1 AUL54_14845 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AUL54_14850 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AUL54_14855 ENOG4108KPW sugar kinase AUL54_14860 ENOG4105FDP GntR family transcriptional regulator AUL54_14865 ENOG4108IJ9 (ABC) transporter AUL54_14870 ENOG4105E2Y ABC, transporter AUL54_14875 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AUL54_14880 ENOG4105GVF (ABC) transporter AUL54_14890 ENOG4108K8S endonuclease I AUL54_14900 ENOG4105C5R Aminotransferase AUL54_14905 ENOG4105XRQ Xanthine dehydrogenase accessory factor AUL54_14920 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AUL54_14925 ENOG4107YV9 domain protein AUL54_14935 ENOG4105VT2 5-hydroxyisourate hydrolase AUL54_14940 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) AUL54_14955 ENOG4105G9B Transcriptional regulator AUL54_14960 ENOG4105CD3 dihydroorotase AUL54_14970 ENOG4105I3N Conserved Protein AUL54_14980 ENOG4107R8B 5'-nucleotidase AUL54_14985 ENOG4108YTE sporulation protein YunB AUL54_14990 ENOG4105FAA peptidase M23 AUL54_14995 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AUL54_15000 ENOG4105MMD transcriptional regulator AUL54_15010 ENOG4105D4U had-superfamily hydrolase, subfamily iia AUL54_15015 ENOG4108W5N phosphatidylglycerophosphatase a AUL54_15025 ENOG4105D6E homoserine dehydrogenase AUL54_15030 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AUL54_15035 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AUL54_15040 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AUL54_15045 ENOG41083MR nifu domain-containing protein AUL54_15060 ENOG4105ZKE UPF0349 protein AUL54_15070 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AUL54_15075 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AUL54_15080 ENOG4108VHC Short-chain dehydrogenase reductase Sdr AUL54_15105 ENOG4105CJ1 ABC, transporter AUL54_15120 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) AUL54_15135 ENOG4105CEP NADH dehydrogenase AUL54_15145 ENOG41069ER domain protein AUL54_15155 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AUL54_15175 ENOG4105NIV Esterase AUL54_15180 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AUL54_15185 ENOG4105E4F Isochorismate synthase AUL54_15190 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AUL54_15195 ENOG4105WQI isochorismatase AUL54_15200 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_15205 ENOG4105WQT MbtH domain protein AUL54_15215 ENOG4105DCF alanine dehydrogenase AUL54_15220 ENOG4108K8K Transcriptional regulator AUL54_15255 ENOG410904N short-chain dehydrogenase reductase AUL54_15270 ENOG4105C02 permease AUL54_15295 ENOG4105DAP Nicotinate phosphoribosyltransferase AUL54_15300 ENOG4105D58 Diguanylate phosphodiesterase AUL54_15325 ENOG4105BZU Histidine kinase AUL54_15335 ENOG4105KA0 thioesterase Superfamily protein AUL54_15340 ENOG4105KJM monovalent cation h antiporter subunit g AUL54_15350 ENOG4105SC1 monovalent cation H antiporter subunit E AUL54_15355 ENOG4108JPZ Monovalent cation H antiporter subunit D AUL54_15360 ENOG4108ZE9 Monovalent cation H antiporter subunit C AUL54_15365 ENOG4105HC0 Na H antiporter AUL54_15370 ENOG4105D65 subunit l AUL54_15385 ENOG4105UIB (ABC) transporter AUL54_15390 ENOG4108JQ9 ABC transporter AUL54_15395 ENOG4105DIH basic membrane AUL54_15400 ENOG4108MRH transcriptional regulatory protein AUL54_15415 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AUL54_15420 ENOG4105BZ4 penicillin-binding protein AUL54_15435 ENOG4105Y38 Kinase-associated protein B AUL54_15440 ENOG4108HGU Histidine kinase AUL54_15445 ENOG4105C87 Aminotransferase class I and II AUL54_15455 ENOG4108MUZ hydrolase AUL54_15460 ENOG4108ZB6 transcriptional regulator AsnC family AUL54_15465 ENOG4105CHM Aminotransferase AUL54_15475 ENOG4105WG9 Conserved Protein AUL54_15480 ENOG4107QW4 alcohol dehydrogenase AUL54_15490 ENOG4105CHJ isochorismatase hydrolase AUL54_15500 ENOG4107QYV phosphohexose isomerase AUL54_15515 ENOG4107PBV potassium channel AUL54_15520 ENOG4107PBV potassium channel AUL54_15535 ENOG4105C37 (CBS) domain AUL54_15545 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AUL54_15550 ENOG4105EA8 2-Nitropropane dioxygenase AUL54_15565 ENOG4105C8Q Methyl-accepting chemotaxis AUL54_15570 ENOG4105C8Q Methyl-accepting chemotaxis AUL54_15575 ENOG4105C8Q Methyl-accepting chemotaxis AUL54_15580 ENOG4105C8Q Methyl-accepting chemotaxis AUL54_15585 ENOG4108Z0Z intracellular protease Pfpi family AUL54_15590 ENOG4105EE0 oxidoreductase AUL54_15600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AUL54_15640 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AUL54_15645 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AUL54_15660 ENOG4105TRT Transcriptional regulator AUL54_15665 ENOG4105C26 Dehydrogenase AUL54_15670 ENOG4108JB8 alcohol dehydrogenase AUL54_15675 ENOG4108VNY MOSC domain protein AUL54_15680 ENOG4106DF1 AUL54_15695 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AUL54_15830 ENOG4105E4F Isochorismate synthase AUL54_15835 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AUL54_15840 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AUL54_15845 ENOG4108IPT Naphthoate synthase AUL54_15850 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_15855 ENOG4105DTQ mandelate racemase muconate lactonizing AUL54_15875 ENOG4105NRA 50s ribosomal protein l31 type b AUL54_15880 ENOG4108V2W Carbonate dehydratase AUL54_15885 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AUL54_15890 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AUL54_15905 ENOG4108RMU ferritin dps family protein AUL54_15920 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AUL54_15930 ENOG4105D2X ABC transporter substrate-binding protein AUL54_15945 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AUL54_15950 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AUL54_15955 ENOG4105CAQ asparagine synthetase AUL54_15960 ENOG4105C85 amino acid AUL54_15965 ENOG4108Z0R Transferase AUL54_15970 ENOG4105E8V Alpha Beta Hydrolase Fold protein AUL54_15995 ENOG4105N5T Radical SAM Protein AUL54_16015 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AUL54_16020 ENOG4105DVE abc transporter atp-binding protein AUL54_16040 ENOG4105C19 ABC transporter AUL54_16045 ENOG4107R34 abc transporter permease protein AUL54_16055 ENOG4105EWM Histidine kinase AUL54_16060 ENOG4105C19 ABC transporter AUL54_16075 ENOG410605W Major Facilitator AUL54_16080 ENOG4105BZU Histidine kinase AUL54_16090 ENOG4105C8T Leucyl-tRNA synthetase AUL54_16095 ENOG41085GJ domain protein AUL54_16115 ENOG4105C94 Transporter AUL54_16120 ENOG4105CBX hi0933 family AUL54_16135 ENOG4105YW5 deoR family transcriptional regulator AUL54_16150 ENOG4105C7N Xanthine uracil vitamin C permease AUL54_16155 ENOG4107QSE Dipeptidase AUL54_16160 ENOG4105C6T cysteine synthase AUL54_16165 ENOG4107F58 2'-5' rna ligase AUL54_16180 ENOG4108V15 phosphotransferase enzyme family AUL54_16190 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AUL54_16195 ENOG4105C8F Beta-lactamase domain protein AUL54_16200 ENOG4105C6K Malic enzyme AUL54_16220 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AUL54_16230 ENOG4108QY0 Membrane AUL54_16245 ENOG4105CZ3 stage V sporulation protein ad AUL54_16250 ENOG41090VF Stage v sporulation protein ac AUL54_16280 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AUL54_16320 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ AUL54_16335 ENOG4108VDD TRNA binding domain protein AUL54_16345 ENOG4105DFU Cell wall formation (By similarity) AUL54_16365 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AUL54_16370 ENOG4105ETE Transcriptional regulator (LacI family AUL54_16375 ENOG4107R0U MotA TolQ exbB proton channel AUL54_16380 ENOG4105ER2 Ompa motb domain protein AUL54_16385 ENOG4105DGU Histone deacetylase AUL54_16390 ENOG4105W87 Cbs domain AUL54_16395 ENOG4105F1V Acetoin utilization protein AUL54_16405 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AUL54_16420 ENOG4108NGU Transcriptional regulator AUL54_16440 ENOG4108Z0Z intracellular protease Pfpi family AUL54_16450 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AUL54_16480 ENOG4105C26 Dehydrogenase AUL54_16485 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AUL54_16490 ENOG4105BZU Histidine kinase AUL54_16500 ENOG4105U5Y Transcriptional regulator AUL54_16525 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) AUL54_16535 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AUL54_16540 ENOG4105EFZ amidohydrolase AUL54_16545 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AUL54_16550 ENOG4105D07 Signal peptide peptidase, SppA AUL54_16555 ENOG4105VK3 rdd domain containing protein AUL54_16565 ENOG4105KBJ sporulation protein ytfj AUL54_16570 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AUL54_16580 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AUL54_16585 ENOG4105EPU Molybdenum cofactor synthesis domain protein AUL54_16590 ENOG4105CDH Citrulline--aspartate ligase AUL54_16595 ENOG4105CH7 arginosuccinase AUL54_16605 ENOG4105E8R UPF0173 metal-dependent hydrolase AUL54_16620 ENOG4105SFS phosphoesterase RecJ domain protein AUL54_16625 ENOG4106EVM AUL54_16635 ENOG4105VV2 AUL54_16640 ENOG4105C0B DNA polymerase III (alpha subunit) AUL54_16645 ENOG4105C6K Malic enzyme AUL54_16650 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AUL54_16655 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AUL54_16660 ENOG4105CTQ phosphohexokinase AUL54_16665 ENOG4105CA9 Pyruvate kinase AUL54_16670 ENOG4105FS0 cytoplasmic membrane protein AUL54_16675 ENOG4108REF Sporulation integral membrane protein ytvi AUL54_16685 ENOG4105BZN citrate synthase AUL54_16690 ENOG4108HMX isocitrate dehydrogenase (NADP) AUL54_16700 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AUL54_16705 ENOG4105BZU Histidine kinase AUL54_16710 ENOG4105C2M dna polymerase I AUL54_16715 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AUL54_16725 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AUL54_16730 ENOG4105CV8 reductase AUL54_16735 ENOG4105F27 Major Facilitator AUL54_16740 ENOG4105KVH Transcriptional regulator AUL54_16745 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AUL54_16750 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AUL54_16775 ENOG4108TDW sporulation protein YtxC AUL54_16780 ENOG4105C22 threonyL-tRNA synthetase AUL54_16785 ENOG4105U0R haloacid dehalogenase-like hydrolase AUL54_16790 ENOG4108HRK Histidine kinase AUL54_16795 ENOG4105DY9 regulatoR AUL54_16805 ENOG41067MG lrgb family AUL54_16810 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AUL54_16815 ENOG4105VJV 50s ribosomal protein L35 AUL54_16820 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AUL54_16825 ENOG410696E Membrane AUL54_16835 ENOG4105CN9 Peptidase m42 family protein AUL54_16840 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase AUL54_16850 ENOG4105EF1 ribulokinase AUL54_16855 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AUL54_16865 ENOG4108MDK Dehydrogenase AUL54_16880 ENOG4105DRS transport system, permease AUL54_16885 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) AUL54_16895 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AUL54_16900 ENOG4105CQB FAD linked oxidase domain protein AUL54_16910 ENOG41067MF small acid-soluble spore protein AUL54_16915 ENOG4108RWN rrna methyltransferase AUL54_16920 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AUL54_16925 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AUL54_16930 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AUL54_16945 ENOG4105DCG PHP domain protein AUL54_16950 ENOG4105C98 muts2 protein AUL54_16965 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_16970 ENOG4107Z3H Transcriptional regulator, TetR family AUL54_16975 ENOG41060WC Enoyl-CoA hydratase AUL54_16980 ENOG4105BZJ Electron transfer flavoprotein AUL54_16985 ENOG4105C10 Electron transfer flavoprotein AUL54_16990 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) AUL54_16995 ENOG4105K63 Thioredoxin AUL54_17000 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AUL54_17005 ENOG4105CFH Aspartokinase AUL54_17015 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AUL54_17025 ENOG4105E33 succinate dehydrogenase AUL54_17035 ENOG4105PFC Transcriptional regulator AUL54_17040 ENOG41067TZ transcriptional regulator, MarR family AUL54_17045 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AUL54_17050 ENOG4108XJQ germination protein AUL54_17055 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AUL54_17060 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AUL54_17065 ENOG4105M59 Phosphodiesterase, mj0936 family AUL54_17085 ENOG4107SCJ type I restriction enzyme EcoKI subunit R AUL54_17130 ENOG4105C7K acetolactate synthase AUL54_17135 ENOG4108ZP8 Acetolactate synthase small subunit AUL54_17140 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AUL54_17150 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AUL54_17155 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AUL54_17160 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AUL54_17170 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AUL54_17175 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AUL54_17180 ENOG4108IUQ atp-dependent protease AUL54_17185 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AUL54_17190 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AUL54_17200 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AUL54_17210 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AUL54_17220 ENOG4105D52 delta-aminolevulinic acid dehydratase AUL54_17225 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AUL54_17230 ENOG41068KH stage VI sporulation protein D AUL54_17235 ENOG4106AR7 Spore coat protein AUL54_17245 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AUL54_17250 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AUL54_17255 ENOG4106A3R peptidase AUL54_17265 ENOG4108Z03 MAF-like protein AUL54_17270 ENOG4105W5Q DNA repair protein (RadC AUL54_17275 ENOG4105DFF Rod shape-determining protein mreb AUL54_17280 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AUL54_17285 ENOG4105YHC Rod shape-determining protein MreD AUL54_17290 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AUL54_17295 ENOG4107QMS site-determining protein AUL54_17310 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AUL54_17315 ENOG4105X36 (ribosomal) protein AUL54_17320 ENOG4105K46 50S ribosomal protein l27 AUL54_17330 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AUL54_17340 ENOG4105CQC Prephenate dehydratase AUL54_17355 ENOG4108IYU L-aspartate oxidase AUL54_17360 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AUL54_17365 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AUL54_17370 ENOG4106678 morphogenetic protein associated with SpoVID AUL54_17385 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AUL54_17390 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AUL54_17395 ENOG41061AI Protein of unknown function (DUF2905) AUL54_17400 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AUL54_17405 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AUL54_17410 ENOG4105VIE preprotein translocase, subunit YajC AUL54_17415 ENOG4105NAP AUL54_17420 ENOG4108QG2 Membrane AUL54_17435 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AUL54_17440 ENOG4105NCW Trka-c domain protein AUL54_17445 ENOG41067VP Protein of unknown function (DUF1049) AUL54_17450 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AUL54_17460 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AUL54_17465 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AUL54_17470 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AUL54_17475 ENOG4105CUT histidyl-tRNA synthetase AUL54_17480 ENOG4105C9M aspartyl-trna synthetase AUL54_17490 ENOG4105CUZ uba thif-type nad fad binding protein AUL54_17495 ENOG4105D1H recombination factor protein RarA AUL54_17505 ENOG4105C3J Cysteine desulfurase AUL54_17510 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AUL54_17520 ENOG4105C7H Helicase, RecD TraA family AUL54_17530 ENOG41060CR AUL54_17535 ENOG4105DRP amino acid AbC transporter AUL54_17540 ENOG4105EAD ABC transporter AUL54_17545 ENOG4105CT1 (ABC) transporter AUL54_17550 ENOG4105CDA abc transporter atp-binding protein AUL54_17555 ENOG4105C02 permease AUL54_17560 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AUL54_17565 ENOG4105VBH UPF0297 protein AUL54_17570 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AUL54_17580 ENOG4105HHA aminodeoxychorismate lyase AUL54_17585 ENOG4108VQJ O-methyltransferase AUL54_17590 ENOG4105XYU peptidase (U32 family) AUL54_17595 ENOG4105CFP Peptidase U32 AUL54_17605 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AUL54_17610 ENOG4107XRG penicillin-binding protein AUL54_17640 ENOG4105C28 cystathionine AUL54_17655 ENOG4108JB9 formate dehydrogenase AUL54_17660 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AUL54_17665 ENOG4105TMB Formate nitrite transporter AUL54_17675 ENOG41082JN Transcriptional regulator AUL54_17680 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AUL54_17685 ENOG4105D94 Major Facilitator Superfamily AUL54_17690 ENOG4108Z66 YbaK ebsC protein AUL54_17705 ENOG4108HCJ Hydrolase AUL54_17730 ENOG4108J8C transporter major facilitator family protein AUL54_17740 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AUL54_17745 ENOG41086D8 Transcriptional regulator AUL54_17805 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AUL54_17810 ENOG4105CSC Glucose uptake protein AUL54_17820 ENOG4105KVH Transcriptional regulator AUL54_17825 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AUL54_17840 ENOG41080BT SNARE associated Golgi AUL54_17845 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AUL54_17850 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AUL54_17870 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AUL54_17875 ENOG4105CQW ribosome biogenesis GTPase YqeH AUL54_17880 ENOG4105E2X shikimate dehydrogenase AUL54_17885 ENOG410812S Rna-binding protein AUL54_17890 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AUL54_17895 ENOG4108WF2 Metal Dependent Phosphohydrolase AUL54_17905 ENOG4108D32 Methyltransferase AUL54_17915 ENOG4105KQC Competence protein AUL54_17920 ENOG4108UK2 deaminase AUL54_17925 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AUL54_17930 ENOG4105TQK DNA polymerase iii, delta' subunit AUL54_17935 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AUL54_17940 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) AUL54_17945 ENOG4108ZRV stage ii sporulation protein p AUL54_17955 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AUL54_17960 ENOG4105CSA Coproporphyrinogen iii oxidase AUL54_17965 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AUL54_17970 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AUL54_17975 ENOG4105CFG Acts as a chaperone (By similarity) AUL54_17980 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AUL54_17985 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AUL54_17990 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AUL54_17995 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AUL54_18010 ENOG4105KTH gatB Yqey AUL54_18015 ENOG4105F7J membrane-bound serine protease AUL54_18020 ENOG4105DI5 UPF0365 protein AUL54_18030 ENOG41068P3 sporulation protein YqfC AUL54_18035 ENOG4105EI1 sporulation protein yqfd AUL54_18040 ENOG4105C9A Phoh family AUL54_18045 ENOG4105CTJ Metal Dependent Phosphohydrolase AUL54_18050 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AUL54_18055 ENOG4107YR5 Diacylglycerol kinase AUL54_18060 ENOG4105KG3 cytidine deaminase AUL54_18065 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AUL54_18070 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) AUL54_18075 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AUL54_18080 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AUL54_18090 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AUL54_18095 ENOG4108UPT UPF0178 protein AUL54_18100 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AUL54_18105 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AUL54_18120 ENOG4105EGD dinuclear metal center protein, YbgI family AUL54_18125 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AUL54_18140 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AUL54_18145 ENOG41069ZM Protein of unknown function (DUF2624) AUL54_18150 ENOG4108JYZ YitT family AUL54_18155 ENOG4105N80 Ferric uptake regulator, Fur family AUL54_18160 ENOG4108U5J '-nucleotidase AUL54_18165 ENOG41063Y9 AUL54_18170 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AUL54_18185 ENOG4105SXS Protein of unknown function (DUF456) AUL54_18190 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AUL54_18200 ENOG4107RF6 penicillin-binding protein AUL54_18205 ENOG4105CVA phosphate AUL54_18210 ENOG4105C8U phosphate abc transporter AUL54_18215 ENOG4105E2Z phosphate ABC transporter (Permease AUL54_18220 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AUL54_18225 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AUL54_18230 ENOG41068DG YceG-like family AUL54_18240 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AUL54_18275 ENOG4105C5X domain protein AUL54_18300 ENOG4105C37 (CBS) domain AUL54_18360 ENOG4105VFR signal peptidase AUL54_18370 ENOG4108IMY Transcriptional regulator AUL54_18385 ENOG4105C0D helicase AUL54_18390 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AUL54_18400 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AUL54_18405 ENOG4105WZW rhodanese family AUL54_18410 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AUL54_18430 ENOG4105CBJ Metal-dependent enzyme AUL54_18440 ENOG4105DC7 peptidase M24 AUL54_18445 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AUL54_18455 ENOG4105CD2 stage iii sporulation protein aa AUL54_18460 ENOG4105KR5 Stage iii sporulation protein AUL54_18465 ENOG4108CQH stage III sporulation protein AC AUL54_18470 ENOG4105KQ4 Stage iii sporulation protein ad AUL54_18480 ENOG410644B Stage III sporulation protein af AUL54_18500 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AUL54_18505 ENOG4108ZSR alkaline shock protein AUL54_18510 ENOG4105M7K Involved in the transcription termination process (By similarity) AUL54_18515 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AUL54_18520 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AUL54_18525 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AUL54_18530 ENOG4105CTB Polyprenyl synthetase AUL54_18535 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AUL54_18540 ENOG4105DX0 Hemolysin A AUL54_18545 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AUL54_18550 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AUL54_18555 ENOG4105S1Z Stage IV sporulation protein B AUL54_18560 ENOG4107QQR Sporulation AUL54_18565 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AUL54_18580 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AUL54_18605 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AUL54_18610 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AUL54_18620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AUL54_18625 ENOG4105C1G acyl-Coa dehydrogenase AUL54_18635 ENOG4105DXD 2-methylcitrate dehydratase AUL54_18640 ENOG4105CR4 methylisocitrate lyase AUL54_18645 ENOG4106CCJ Protein of unknown function (DUF2627) AUL54_18650 ENOG4108JUB Transcriptional regulator AUL54_18660 ENOG4107RDP Dehydrogenase AUL54_18665 ENOG4105CKM Branched-chain carboxylic acid kinase AUL54_18680 ENOG4105CPP Dehydrogenase, E1 component AUL54_18685 ENOG4105C7S Dehydrogenase AUL54_18690 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AUL54_18695 ENOG4108Y6J UPF0403 protein AUL54_18700 ENOG4108HW3 (ABC) transporter AUL54_18705 ENOG4105E5Q amino acid AbC transporter AUL54_18710 ENOG4105CDA abc transporter atp-binding protein AUL54_18715 ENOG4108QEG Membrane AUL54_18720 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AUL54_18725 ENOG4108ZVT methylmalonyl-coA epimerase AUL54_18730 ENOG4108HNZ carboxyl transferase AUL54_18735 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AUL54_18740 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) AUL54_18750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AUL54_18755 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AUL54_18760 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AUL54_18765 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AUL54_18775 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AUL54_18780 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AUL54_18785 ENOG4107QKG PfaD family AUL54_18800 ENOG4105CEY Amp-dependent synthetase and ligase AUL54_18805 ENOG4105CHR reductase AUL54_18815 ENOG4105C0W non-ribosomal peptide synthetase AUL54_18825 ENOG4105C0W non-ribosomal peptide synthetase AUL54_18830 ENOG4105C0W non-ribosomal peptide synthetase AUL54_18845 ENOG4106A3M Cytochrome p-450 AUL54_18850 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase AUL54_18855 ENOG4108KQ6 Enoyl-CoA hydratase AUL54_18860 ENOG4105II7 pyrroline-5-carboxylate reductase AUL54_18865 ENOG41069FQ Metallo-beta-lactamase superfamily AUL54_18870 ENOG4108IXY short-chain dehydrogenase reductase AUL54_18880 ENOG4105CS9 pantothenic acid kinase AUL54_18885 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase AUL54_18895 ENOG4105C02 permease AUL54_18910 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AUL54_18915 ENOG4108XET gCN5-related N-acetyltransferase AUL54_18920 ENOG4105KAC Antibiotic biosynthesis monooxygenase AUL54_18925 ENOG4105RHY Pfam:UPF0157 AUL54_18930 ENOG4106HZJ AUL54_18950 ENOG4105CPC Aldo Keto reductase AUL54_18960 ENOG4108YZ4 nudix hydrolase AUL54_18970 ENOG4108IMY Transcriptional regulator AUL54_18975 ENOG4105HDK L-asparaginase AUL54_18980 ENOG4108IJ0 Aspartate ammonia-lyase AUL54_18985 ENOG4105DFD Na H antiporter AUL54_19005 ENOG4105MZ9 stage II sporulation protein m AUL54_19010 ENOG4105I3K Ferric uptake regulator, Fur family AUL54_19020 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AUL54_19025 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AUL54_19030 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AUL54_19035 ENOG4105DZ1 carboxypeptidase AUL54_19040 ENOG41082AN stage II sporulation protein AUL54_19045 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AUL54_19050 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AUL54_19065 ENOG41090VF Stage v sporulation protein ac AUL54_19070 ENOG4105CZ3 stage V sporulation protein ad AUL54_19080 ENOG4105G6R Stage v sporulation protein ae AUL54_19090 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AUL54_19095 ENOG4105PTM secreted protein AUL54_19100 ENOG4107ZE5 PPIases accelerate the folding of proteins AUL54_19125 ENOG4108R6K riboflavin synthase, subunit alpha AUL54_19130 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AUL54_19135 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AUL54_19150 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AUL54_19155 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AUL54_19165 ENOG4105DZ1 carboxypeptidase AUL54_19170 ENOG4108JIC nucleoside recognition domain protein AUL54_19180 ENOG4105FE9 pseudouridine synthase AUL54_19190 ENOG4107TWT Cytochrome c biogenesis protein AUL54_19195 ENOG4105CRE cytochrome C AUL54_19200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AUL54_19205 ENOG4105BZU Histidine kinase AUL54_19220 ENOG4108JQ1 Dehydrogenase AUL54_19225 ENOG4108SAX Membrane AUL54_19235 ENOG4105T7X AUL54_19240 ENOG4105C9U ATP-dependent DNA helicase RecQ AUL54_19245 ENOG4105I7S Abortive infection protein AUL54_19260 ENOG4107RGJ metallophosphoesterase AUL54_19275 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AUL54_19280 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) AUL54_19290 ENOG4105MSI germination protein ypeb AUL54_19300 ENOG4105CAT Cytidine monophosphate kinase AUL54_19305 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AUL54_19320 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AUL54_19325 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AUL54_19340 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AUL54_19345 ENOG4105K70 DNA-binding protein AUL54_19350 ENOG4105EUJ GTP cyclohydrolase i AUL54_19355 ENOG4105WP2 Tryptophan RNA-binding attenuator protein AUL54_19360 ENOG4105XXQ heptaprenyl diphosphate synthase component I AUL54_19365 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AUL54_19370 ENOG4105EAH synthase AUL54_19375 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AUL54_19380 ENOG4105BZU Histidine kinase AUL54_19385 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AUL54_19395 ENOG4105KHN chorismate mutase AUL54_19400 ENOG4105CRQ synthase (Component I) AUL54_19410 ENOG4105DK0 Indole-3-glycerol phosphate synthase AUL54_19415 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AUL54_19420 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AUL54_19430 ENOG4105CIH Imidazole acetol-phosphate transaminase AUL54_19440 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AUL54_19445 ENOG41068YB TPR repeat-containing protein AUL54_19465 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AUL54_19485 ENOG4105F0F Oxalate decarboxylase AUL54_19490 ENOG4108JYZ YitT family AUL54_19495 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AUL54_19500 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AUL54_19505 ENOG4108Z5K methylglyoxal synthase AUL54_19510 ENOG4105FJR Lmbe family AUL54_19515 ENOG4105CPK Glycosyl transferase (Group 1 AUL54_19520 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AUL54_19525 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AUL54_19530 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AUL54_19540 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AUL54_19545 ENOG4105DVT helicase AUL54_19555 ENOG4105CHM Aminotransferase AUL54_19560 ENOG4105C5S asparaginyl-tRNA synthetase AUL54_19570 ENOG4105CSM endonuclease III AUL54_19580 ENOG4105BZ4 penicillin-binding protein AUL54_19585 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AUL54_19630 ENOG4108I5C dEAD DEAH box helicase AUL54_19635 ENOG4107X2U Inherit from COG: Exonuclease-like protein AUL54_19640 ENOG4108UKS UPF0398 protein AUL54_19645 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) AUL54_19655 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AUL54_19665 ENOG4105DVT helicase AUL54_19670 ENOG4105CTD carboxy-peptidase AUL54_19675 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AUL54_19680 ENOG4105C2W permease AUL54_19690 ENOG4107Y9E nuclease AUL54_19705 ENOG4106BHF AUL54_19715 ENOG41090AA AUL54_19730 ENOG4108YTE sporulation protein YunB AUL54_19740 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AUL54_19770 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AUL54_19795 ENOG4105E4C Lytic transglycosylase catalytic AUL54_19840 ENOG41068G1 AUL54_19950 ENOG4105K70 DNA-binding protein AUL54_19955 ENOG4105ZUG AUL54_19995 ENOG4108NE4 AUL54_20055 ENOG4107NTZ AUL54_20135 ENOG4107D0N AUL54_20215 ENOG4105GJD protein, conserved in bacteria AUL54_20235 ENOG4108J9Q DNA ligase AUL54_20240 ENOG4108RAV Conserved protein AUL54_20260 ENOG4105K7W phage-related replication protein AUL54_20285 ENOG4106YR8 AUL54_20290 ENOG41088HM AUL54_20300 ENOG4106PTB DnaB-like helicase C terminal domain AUL54_20305 ENOG4106IVX