locus-tag class description DN405_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN405_00015 ENOG410848D S4 domain protein YaaA DN405_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN405_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DN405_00100 ENOG4105ZMH deoxynucleoside kinase DN405_00110 ENOG4105GTG Isochorismatase DN405_00120 ENOG4108Z6B deaminase DN405_00130 ENOG4105C6E dna polymerase iii DN405_00150 ENOG41067KS pro-sigma K processing DN405_00185 ENOG4105CXN decarboxylase DN405_00195 ENOG4105FA2 dna polymerase iii DN405_00200 ENOG4105MA4 psp1 domain protein DN405_00210 ENOG41060K3 Methyltransferase DN405_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DN405_00225 ENOG4105KRN Transcriptional regulator, abrb family DN405_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN405_00235 ENOG4105F8V Hydrolase, tatD family DN405_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DN405_00250 ENOG4105XFA sporulation peptidase YabG DN405_00255 ENOG4105W42 Veg protein DN405_00270 ENOG4105DFT pur operon repressor DN405_00275 ENOG4105KME endoribonuclease L-psp DN405_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DN405_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DN405_00305 ENOG4108JA2 transcriptioN-repair coupling factor DN405_00310 ENOG4108M14 stage v sporulation protein t DN405_00320 ENOG4108IY2 MazG family DN405_00325 ENOG41082I2 s4 domain protein DN405_00330 ENOG4105VYY sporulation protein yabp DN405_00345 ENOG41060GV RNA binding s1 domain protein DN405_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DN405_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN405_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DN405_00390 ENOG4105C6T cysteine synthase DN405_00395 ENOG4105CRQ synthase (Component I) DN405_00400 ENOG4105DDQ anthranilate synthase DN405_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DN405_00410 ENOG4105EEI dihydropteroate synthase DN405_00415 ENOG4105KRF dihydroneopterin aldolase DN405_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DN405_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DN405_00520 ENOG4108Z0C Uvrb UvrC protein DN405_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DN405_00545 ENOG4105CTP PilT protein domain protein DN405_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DN405_00565 ENOG4105D7W serine acetyltransferase DN405_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 DN405_00585 ENOG4105M0M Tetracycline resistance protein DN405_00590 ENOG4105QIV RNA polymerase DN405_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DN405_00630 ENOG4107Y49 methyltransferase DN405_00645 ENOG4105XPM ribosomal protein DN405_00755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DN405_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN405_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN405_00800 ENOG41067V7 50S ribosomal protein L36 DN405_00825 ENOG4108JJB ABC transporter DN405_00830 ENOG4108JJB ABC transporter DN405_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DN405_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN405_00865 ENOG4105D1F ATP-binding protein DN405_00880 ENOG4108NMV polysaccharide deacetylase DN405_00960 ENOG4105C8B TIGR00159 family DN405_00965 ENOG4107U5W ybbr family DN405_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DN405_01005 ENOG4108PSK reductase DN405_01010 ENOG4108UMI ABC transporter, permease DN405_01015 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DN405_01020 ENOG4105D01 (LipO)protein DN405_01025 ENOG4105CB2 alcohol dehydrogenase DN405_01035 ENOG4105IQ5 FAD linked oxidase domain protein DN405_01050 ENOG4105C2C drug resistance transporter, Bcr CflA DN405_01065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN405_01070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN405_01075 ENOG4105C3U ABC transporter DN405_01080 ENOG4108JQ7 (ABC) transporter DN405_01110 ENOG4108J59 Extracellular solute-binding protein, family 5 DN405_01115 ENOG4108J59 Extracellular solute-binding protein, family 5 DN405_01125 ENOG4105II7 pyrroline-5-carboxylate reductase DN405_01135 ENOG4105E0C molybdate abc transporter DN405_01140 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DN405_01145 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DN405_01155 ENOG4105EGI Transcriptional regulator DN405_01175 ENOG4105F6E Acyl-transferase DN405_01195 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN405_01210 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DN405_01230 ENOG4105C5H ABC transporter DN405_01245 ENOG4105DEF Extracellular solute-binding protein, family 5 DN405_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN405_01260 ENOG4105C3U ABC transporter DN405_01265 ENOG4108JQ7 (ABC) transporter DN405_01270 ENOG410667J hydrolase DN405_01300 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DN405_01305 ENOG4105ERH Fumarylacetoacetate hydrolase DN405_01315 ENOG4105CUB amino acid DN405_01320 ENOG4108SC4 )-transporter DN405_01325 ENOG4105CPF Cell wall formation (By similarity) DN405_01330 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DN405_01355 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DN405_01360 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN405_01370 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DN405_01475 ENOG4105K8N protein family UPF0079, ATPase DN405_01480 ENOG41072GX Peptidase M22 Glycoprotease DN405_01485 ENOG410801F ribosomal-protein-alanine acetyltransferase DN405_01490 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DN405_01495 ENOG4105C5H ABC transporter DN405_01510 ENOG4108TYN CAAX amino terminal protease family protein DN405_01530 ENOG4105C7N Xanthine uracil vitamin C permease DN405_01540 ENOG4105BZU Histidine kinase DN405_01570 ENOG4107ZXU DSBA oxidoreductase DN405_01620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN405_01650 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN405_01660 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) DN405_01690 ENOG4105SX7 Transporter DN405_01720 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DN405_01725 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DN405_01730 ENOG4105C83 adenylosuccinate lyase DN405_01740 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DN405_01765 ENOG4108V3E phosphoribosylglycinamide formyltransferase DN405_01775 ENOG4105C12 Phosphoribosylglycinamide synthetase DN405_01805 ENOG4105C4R Atp-dependent dna helicase DN405_01810 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DN405_01830 ENOG4108W2Y isochorismatase DN405_01835 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DN405_01840 ENOG4108UMI ABC transporter, permease DN405_01845 ENOG4105D01 (LipO)protein DN405_01865 ENOG410834F Transcriptional regulator DN405_01870 ENOG4107I77 yiaA/B two helix domain DN405_01880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN405_01890 ENOG4105CBD Diacylglycerol kinase DN405_01900 ENOG4108JPW Aminotransferase DN405_01910 ENOG4105C26 Dehydrogenase DN405_01915 ENOG4105KPY Small multidrug resistance protein DN405_01940 ENOG4105D9N nucleoside DN405_01945 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DN405_01955 ENOG4108W15 Protein of unknown function (DUF1456) DN405_01975 ENOG4105DTQ mandelate racemase muconate lactonizing DN405_01985 ENOG4105DFD Na H antiporter DN405_02005 ENOG4105D3R alkyl hydroperoxide reductase DN405_02010 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DN405_02015 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DN405_02020 ENOG4107W7X Aldolase DN405_02025 ENOG4105EHG Permease protein DN405_02030 ENOG4105DQ5 transport system permease protein DN405_02035 ENOG4108V5C ABC transporter DN405_02045 ENOG4105CAY ferredoxin--nadp reductase DN405_02065 ENOG4106UIA DN405_02070 ENOG4106UIA DN405_02085 ENOG4105BZU Histidine kinase DN405_02105 ENOG410756H nucleotidyltransferase DN405_02110 ENOG4105D2S major facilitator superfamily DN405_02125 ENOG4105E5Q amino acid AbC transporter DN405_02130 ENOG4105EAB amino acid AbC transporter DN405_02140 ENOG4105C8Q Methyl-accepting chemotaxis DN405_02155 ENOG4105DBV ornithine carbamoyltransferase DN405_02165 ENOG4105C5B carbamate kinase DN405_02170 ENOG4108W63 CRP FNR family transcriptional regulator DN405_02180 ENOG4105DNP FAD linked oxidase domain protein DN405_02190 ENOG4105CI1 PTS System DN405_02205 ENOG4105C9U ATP-dependent DNA helicase RecQ DN405_02220 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DN405_02240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN405_02245 ENOG4105D2X ABC transporter substrate-binding protein DN405_02285 ENOG41062JF Transcriptional regulator DN405_02300 ENOG4105DEU major facilitator superfamily DN405_02315 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DN405_02335 ENOG4108N0M stress protein DN405_02340 ENOG4106FN3 tellurium resistance protein DN405_02345 ENOG4106FN3 tellurium resistance protein DN405_02350 ENOG4107TS3 membrane protein, TerC DN405_02355 ENOG4108TTB tellurium resistance protein DN405_02370 ENOG41068PA UPF0435 protein DN405_02375 ENOG4105KJF protein tyrosine phosphatase DN405_02385 ENOG4107U9T Pfam:Ribonuclease_BN DN405_02390 ENOG4105C59 p-type ATPase DN405_02395 ENOG4108IPJ Membrane DN405_02415 ENOG4107ZTW SNARE associated Golgi DN405_02430 ENOG410606W general stress protein DN405_02435 ENOG4105UPD Calcium Proton DN405_02470 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DN405_02475 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DN405_02485 ENOG4108JUB Transcriptional regulator DN405_02495 ENOG4108IQI permease DN405_02535 ENOG4108A04 Beta-lactamase DN405_02550 ENOG4105CKK Glycosyl transferase, family 2 DN405_02555 ENOG4107QQG Dehydrogenase DN405_02560 ENOG4105C3I Nad-dependent epimerase dehydratase DN405_02580 ENOG4105F1A Pyruvate formate-lyase DN405_02600 ENOG4105CI2 imidazolone-5-propionate hydrolase DN405_02605 ENOG4105ECP epimerase DN405_02635 ENOG41067AE Membrane-bound metal-dependent hydrolase DN405_02640 ENOG4105CEN a g-specific adenine glycosylase DN405_02645 ENOG4106BXE DN405_02665 ENOG4105BZ1 (ABC) transporter DN405_02670 ENOG4107NBY Membrane DN405_02675 ENOG4105CBC glutamate synthase DN405_02685 ENOG4108IUW ABC transporter DN405_02705 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN405_02710 ENOG4105G5W regulator Fur family DN405_02820 ENOG4105CDY transcriptional regulatory protein DN405_02830 ENOG4108JQC penicillin-binding protein 1A DN405_02835 ENOG4108R9S DSBA oxidoreductase DN405_02845 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DN405_02855 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DN405_02860 ENOG4105BZU Histidine kinase DN405_02865 ENOG4105CYN Serine protein kinase DN405_02885 ENOG4105C94 Transporter DN405_02900 ENOG4105DZ6 Band 7 protein DN405_02910 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DN405_02915 ENOG4108V9W transcriptional regulatory protein DN405_02920 ENOG4105D4T Citrate transporter DN405_02945 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN405_02950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN405_02955 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DN405_02960 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DN405_02965 ENOG4105BZ7 extracellular solute-binding protein family 1 DN405_02970 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DN405_02975 ENOG4108STX response regulator DN405_02980 ENOG41062D9 Histidine kinase DN405_03005 ENOG4108MRH transcriptional regulatory protein DN405_03015 ENOG4105C6K Malic enzyme DN405_03025 ENOG4108UZ3 Transporter DN405_03030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN405_03040 ENOG4105BZU Histidine kinase DN405_03050 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN405_03055 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN405_03060 ENOG4108JB9 formate dehydrogenase DN405_03080 ENOG4105CUB amino acid DN405_03095 ENOG4105C59 p-type ATPase DN405_03100 ENOG4105DAP Nicotinate phosphoribosyltransferase DN405_03130 ENOG41073R8 VanW family DN405_03135 ENOG4108KGH TRANSCRIPTIONal DN405_03140 ENOG4105D9N nucleoside DN405_03145 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DN405_03150 ENOG4105C37 (CBS) domain DN405_03155 ENOG4108IJ0 Aspartate ammonia-lyase DN405_03160 ENOG4105DAA L-lactate DN405_03175 ENOG4105DUX Transporter DN405_03180 ENOG4108MES Periplasmic binding protein DN405_03185 ENOG4105DQ5 transport system permease protein DN405_03190 ENOG4108IHU transport system permease protein DN405_03195 ENOG4105E0A ABC, transporter DN405_03200 ENOG4105DMQ Methyltransferase DN405_03205 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DN405_03210 ENOG4105EXW epimerase dehydratase DN405_03220 ENOG4107T89 von Willebrand factor, type A DN405_03225 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DN405_03230 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN405_03240 ENOG4105BZU Histidine kinase DN405_03245 ENOG4105D5Q Arginine ornithine antiporter DN405_03250 ENOG4107414 GntR family transcriptional regulator DN405_03255 ENOG4105C5Y PTS System DN405_03260 ENOG4105CG3 alpha amylase, catalytic region DN405_03275 ENOG4105E1K spore germination protein DN405_03280 ENOG4105CRN Aminoglycoside phosphotransferase DN405_03285 ENOG4105BZG amino acid carrier protein DN405_03295 ENOG4105CDA abc transporter atp-binding protein DN405_03300 ENOG4105CT1 (ABC) transporter DN405_03305 ENOG4105EAD ABC transporter DN405_03310 ENOG4105DRP amino acid AbC transporter DN405_03315 ENOG4108IQI permease DN405_03330 ENOG4105D29 Helix-turn-helix type 11 domain protein DN405_03335 ENOG4105NAE bifunctional deaminase-reductase domain protein DN405_03340 ENOG4105BZU Histidine kinase DN405_03365 ENOG4105CHH sulfate transporter DN405_03370 ENOG41068KF Universal stress protein DN405_03380 ENOG4105CXY transporter DN405_03385 ENOG41067TZ transcriptional regulator, MarR family DN405_03390 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN405_03395 ENOG4105ETE Transcriptional regulator (LacI family DN405_03400 ENOG4108RVA ribokinase DN405_03410 ENOG4105C2J ABC transporter DN405_03415 ENOG4105CNN ABC, transporter DN405_03420 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DN405_03425 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DN405_03460 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) DN405_03490 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN405_03495 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN405_03500 ENOG41069ER domain protein DN405_03505 ENOG4105VZ8 Transcriptional regulator DN405_03510 ENOG4107D63 DN405_03525 ENOG4105DUX Transporter DN405_03545 ENOG4105C85 amino acid DN405_03550 ENOG4105C7N Xanthine uracil vitamin C permease DN405_03565 ENOG4105MA6 gCN5-related N-acetyltransferase DN405_03585 ENOG4105CCU oxidase (Subunit III) DN405_03590 ENOG4105BZ9 Cytochrome C oxidase, subunit I DN405_03595 ENOG4105E2S oxidase) subunit II DN405_03615 ENOG4106CAD Protein of unknown function (DUF3311) DN405_03620 ENOG4105E1V na solute symporter DN405_03635 ENOG4108NHD germination protein DN405_03640 ENOG4105CE1 Ferrous iron transport protein b DN405_03645 ENOG4105CE1 Ferrous iron transport protein b DN405_03650 ENOG4105CE1 Ferrous iron transport protein b DN405_03655 ENOG4105CVA phosphate DN405_03660 ENOG4105C8U phosphate abc transporter DN405_03665 ENOG4105E2Z phosphate ABC transporter (Permease DN405_03795 ENOG41080XQ Signal transduction protein with cbs domains DN405_03815 ENOG4105ETU transcriptional activator (TenA DN405_03825 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DN405_03835 ENOG4108VEU Thiamine monophosphate synthase DN405_03840 ENOG41080HI glycine oxidase DN405_03855 ENOG4105D06 uba thif-type nad fad binding protein DN405_03860 ENOG4105DWF phosphomethylpyrimidine kinase DN405_03910 ENOG4108INS Transcriptional regulator DN405_03920 ENOG4105C7N Xanthine uracil vitamin C permease DN405_03930 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN405_03950 ENOG4105C5Y PTS System DN405_03965 ENOG4105K63 Thioredoxin DN405_03985 ENOG4108B31 Spore germination protein DN405_04005 ENOG4107Y03 Nitroreductase DN405_04010 ENOG4105ED1 spovr family DN405_04020 ENOG4108TCS Glutamyl endopeptidase DN405_04045 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DN405_04050 ENOG4105XTG Pfam:DUF156 DN405_04055 ENOG4105VFE sira family DN405_04060 ENOG4107TPS domain protein DN405_04065 ENOG4105VFE sira family DN405_04070 ENOG4105VFE sira family DN405_04075 ENOG41085GJ domain protein DN405_04080 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DN405_04085 ENOG41087NI Sulfite exporter TauE/SafE DN405_04095 ENOG4108KGH TRANSCRIPTIONal DN405_04125 ENOG4105EMD TRANSCRIPTIONal DN405_04130 ENOG4105VCP PTS System DN405_04135 ENOG4105VZJ PTS System DN405_04160 ENOG41069ER domain protein DN405_04165 ENOG4107RBB ABC transporter, permease DN405_04170 ENOG4105C19 ABC transporter DN405_04200 ENOG4105WEF catalase DN405_04235 ENOG4107T5V SNARE associated Golgi DN405_04265 ENOG4105CUB amino acid DN405_04270 ENOG4107RWR Sodium hydrogen exchanger DN405_04280 ENOG4106KNT transcriptional regulator DN405_04320 ENOG4108YXU transcriptional regulator AsnC family DN405_04325 ENOG4105CH7 arginosuccinase DN405_04330 ENOG4108IXY short-chain dehydrogenase reductase DN405_04345 ENOG4105KPY Small multidrug resistance protein DN405_04380 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN405_04385 ENOG4105E5W Transporter DN405_04395 ENOG4105CH6 catalase DN405_04405 ENOG4105D5Q Arginine ornithine antiporter DN405_04420 ENOG4105C26 Dehydrogenase DN405_04435 ENOG4105BZ1 (ABC) transporter DN405_04440 ENOG4105BZ1 (ABC) transporter DN405_04455 ENOG4105DRP amino acid AbC transporter DN405_04460 ENOG4105CDA abc transporter atp-binding protein DN405_04475 ENOG410839P DN405_04485 ENOG4108UH6 UPF0754 membrane protein DN405_04510 ENOG4107FQX Alpha-acetolactate decarboxylase DN405_04535 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN405_04540 ENOG4105D4P Coproporphyrinogen iii oxidase DN405_04545 ENOG4105CEY Amp-dependent synthetase and ligase DN405_04560 ENOG4105CHH sulfate transporter DN405_04590 ENOG4105CGU Enoyl-CoA hydratase DN405_04610 ENOG4105DER m42 family DN405_04635 ENOG4105CIF Ornithine Cyclodeaminase DN405_04650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN405_04660 ENOG4108JQ7 (ABC) transporter DN405_04690 ENOG4105CSH Transporter DN405_04700 ENOG4108MRH transcriptional regulatory protein DN405_04755 ENOG4105CDU Replicative dna helicase DN405_04780 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN405_04795 ENOG4105D9U N-acetyltransferase DN405_04820 ENOG4105F6J Alpha beta hydrolase fold DN405_04860 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN405_04880 ENOG4105CMT Dihydroxyacetone kinase DN405_04895 ENOG4105CMT Dihydroxyacetone kinase DN405_04955 ENOG4108WC5 Alpha Beta Hydrolase Fold protein DN405_05015 ENOG4105WN5 stage II sporulation protein DN405_05025 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN405_05035 ENOG4108MJI response regulator DN405_05040 ENOG4105BZU Histidine kinase DN405_05045 ENOG4105BZU Histidine kinase DN405_05065 ENOG4105K8R UPF0145 protein DN405_05080 ENOG4107QHE Choloylglycine hydrolase DN405_05100 ENOG4107VRP DNA repair exonuclease DN405_05105 ENOG4106D4I domain protein DN405_05140 ENOG4108MUZ hydrolase DN405_05155 ENOG4105F0F Oxalate decarboxylase DN405_05160 ENOG41067QW Transcriptional regulator DN405_05165 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DN405_05180 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DN405_05195 ENOG4105DU6 RNA polymerase DN405_05215 ENOG4105EYF MMPL domain protein DN405_05220 ENOG4105EEM helicase DN405_05230 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN405_05260 ENOG4105K59 histidine triad (HIT) protein DN405_05290 ENOG410905X membrane-flanked domain protein DN405_05295 ENOG4105CKV Membrane DN405_05340 ENOG410905X membrane-flanked domain protein DN405_05345 ENOG4105CKV Membrane DN405_05350 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DN405_05355 ENOG4105BZ4 penicillin-binding protein DN405_05365 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DN405_05370 ENOG4105C1Q protoporphyrinogen oxidase DN405_05400 ENOG4105ECB domain protein DN405_05430 ENOG4108MK9 spermidine N(1)-acetyltransferase DN405_05440 ENOG4106AXD DN405_05445 ENOG4108RQ5 Beta-lactamase domain-containing protein DN405_05450 ENOG4105DF9 Lipoate-protein, ligase DN405_05460 ENOG4105CEY Amp-dependent synthetase and ligase DN405_05470 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DN405_05475 ENOG4108I5D sulfate abc transporter DN405_05480 ENOG4105ECW sulfate abc transporter DN405_05485 ENOG4108IJ6 ABC transporter DN405_05550 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DN405_05560 ENOG4107RN3 metallophosphoesterase DN405_05565 ENOG4107TVP HD domain protein DN405_05575 ENOG4108AEY RNA polymerase sigma factor DN405_05580 ENOG41086D8 Transcriptional regulator DN405_05590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN405_05610 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DN405_05615 ENOG4105C8Q Methyl-accepting chemotaxis DN405_05620 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) DN405_05630 ENOG4107QP3 malate synthase g DN405_05650 ENOG4105VEQ Cold shock protein DN405_05730 ENOG4105ERH Fumarylacetoacetate hydrolase DN405_05740 ENOG4105C8Y Acetylornithine aminotransferase DN405_05745 ENOG4106BKT UPF0344 protein DN405_05755 ENOG4105CAQ asparagine synthetase DN405_05760 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DN405_05765 ENOG4105CH6 catalase DN405_05770 ENOG4105BZU Histidine kinase DN405_05790 ENOG4108VPT UPF0234 protein DN405_05795 ENOG4105QNR S1 RNA binding domain protein DN405_05800 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN405_05810 ENOG4107AYK membrAne DN405_05815 ENOG41073B9 DN405_05825 ENOG4108KP7 hydrolase DN405_05835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DN405_05860 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DN405_05865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DN405_05885 ENOG4105C31 Tryptophanyl-tRNA synthetase DN405_05905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DN405_05910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DN405_05920 ENOG4108JQ7 (ABC) transporter DN405_05925 ENOG4105UQX Mate efflux family protein DN405_05945 ENOG4108ZCF integral membrane protein DN405_05955 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN405_05965 ENOG4105DPN Oligoendopeptidase f DN405_05975 ENOG4108Z18 K06886 hemoglobin DN405_05980 ENOG4105MIX Adenylate cyclase DN405_05985 ENOG4106EFP UPF0738 protein DN405_05995 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DN405_06000 ENOG4105EMS pseudouridine synthase DN405_06020 ENOG4105K64 Glycosyl transferase, family 2 DN405_06040 ENOG4107TVC Glycosyl transferase, family 2 DN405_06060 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DN405_06065 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DN405_06075 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DN405_06125 ENOG4108ZMI UPF0477 protein DN405_06155 ENOG4105CK7 Sodium proline symporter DN405_06165 ENOG4105CRQ synthase (Component I) DN405_06170 ENOG4105DDQ anthranilate synthase DN405_06180 ENOG4105DK0 Indole-3-glycerol phosphate synthase DN405_06195 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DN405_06260 ENOG4105C7S Dehydrogenase DN405_06265 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DN405_06270 ENOG4105VZ8 Transcriptional regulator DN405_06330 ENOG4105DZ1 carboxypeptidase DN405_06335 ENOG4105VFR signal peptidase DN405_06370 ENOG4105C26 Dehydrogenase DN405_06375 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN405_06380 ENOG4105F38 ABC transporter, permease DN405_06385 ENOG4105D38 putrescine abc transporter DN405_06390 ENOG4107RUE extracellular solute-binding protein family 1 DN405_06400 ENOG4105EYF MMPL domain protein DN405_06410 ENOG4108YBP pseudouridine synthase DN405_06420 ENOG4105K4I Scp-like extracellular DN405_06425 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DN405_06430 ENOG4105CQB FAD linked oxidase domain protein DN405_06445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_06450 ENOG4105BZU Histidine kinase DN405_06455 ENOG4105JXH GntR family transcriptional regulator DN405_06475 ENOG4106A3R peptidase DN405_06485 ENOG4108QTI )-transporter DN405_06490 ENOG4107TS3 membrane protein, TerC DN405_06495 ENOG4105CZN Potassium uptake protein DN405_06500 ENOG410681C small acid-soluble spore protein DN405_06505 ENOG4108Z7G MaoC domain protein dehydratase DN405_06525 ENOG4105CHR reductase DN405_06555 ENOG4105C4Y ABC transporter DN405_06560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DN405_06565 ENOG4107RCV ABC transporter, permease DN405_06585 ENOG4105E98 transcriptional regulator DeoR family DN405_06595 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DN405_06605 ENOG4105PXI polysaccharide deacetylase DN405_06615 ENOG4105BZU Histidine kinase DN405_06620 ENOG41090MY MarR family Transcriptional regulator DN405_06630 ENOG4106DF1 DN405_06635 ENOG4105BZU Histidine kinase DN405_06640 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DN405_06645 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DN405_06650 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DN405_06690 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DN405_06695 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DN405_06700 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DN405_06705 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN405_06710 ENOG4105CZV ABC transporter DN405_06720 ENOG4105CJ1 ABC, transporter DN405_06760 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DN405_06765 ENOG4105EA8 2-Nitropropane dioxygenase DN405_06770 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN405_06780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DN405_06800 ENOG4105NQC Flavodoxin DN405_06830 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN405_06860 ENOG4105CZN Potassium uptake protein DN405_06865 ENOG41063Y9 DN405_06870 ENOG4105KBJ sporulation protein ytfj DN405_06890 ENOG4105CM2 brancheD-chain amino acid aminotransferase DN405_06895 ENOG4105C7K acetolactate synthase DN405_06900 ENOG4108ZP8 Acetolactate synthase small subunit DN405_06905 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DN405_06920 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DN405_06940 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DN405_06945 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DN405_06970 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase DN405_06975 ENOG4107RVV histidinol phosphate phosphatase, hisj family DN405_06990 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN405_06995 ENOG4105E0M Sulfatase DN405_07005 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DN405_07020 ENOG4107S4M Sulfate adenylate transferase DN405_07025 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DN405_07030 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DN405_07040 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN405_07045 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN405_07050 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN405_07055 ENOG4105C8J )-transporter DN405_07075 ENOG4105DFD Na H antiporter DN405_07095 ENOG4105ENE Histidine kinase DN405_07100 ENOG4105WH1 Two component transcriptional regulator luxr family DN405_07120 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN405_07145 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DN405_07165 ENOG4105CJ3 phosphate transporter DN405_07170 ENOG4107GRR phosphate transport regulator DN405_07175 ENOG4105BZ4 penicillin-binding protein DN405_07190 ENOG4105BZU Histidine kinase DN405_07195 ENOG4105I3N Conserved Protein DN405_07210 ENOG4105BZU Histidine kinase DN405_07245 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN405_07250 ENOG4105DZ1 carboxypeptidase DN405_07255 ENOG4108JIC nucleoside recognition domain protein DN405_07265 ENOG4105FE9 pseudouridine synthase DN405_07270 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN405_07275 ENOG4107TWT Cytochrome c biogenesis protein DN405_07280 ENOG4105CRE cytochrome C DN405_07285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_07290 ENOG4105BZU Histidine kinase DN405_07295 ENOG4108WBT adenosyltransferase DN405_07310 ENOG4108SAX Membrane DN405_07325 ENOG4105C9U ATP-dependent DNA helicase RecQ DN405_07330 ENOG4105I7S Abortive infection protein DN405_07340 ENOG4107RGJ metallophosphoesterase DN405_07345 ENOG4108XDN Transcriptional regulator DN405_07350 ENOG4108S6Z Negative regulator of genetic competence DN405_07375 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DN405_07380 ENOG4107RB3 L-asparaginase DN405_07395 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DN405_07410 ENOG4105S2F DN405_07415 ENOG41065D1 DN405_07445 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DN405_07460 ENOG4105XXQ heptaprenyl diphosphate synthase component I DN405_07470 ENOG4105EAH synthase DN405_07475 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DN405_07480 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN405_07495 ENOG41068YB TPR repeat-containing protein DN405_07510 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DN405_07515 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DN405_07550 ENOG4108JYZ YitT family DN405_07560 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DN405_07575 ENOG4105FJR Lmbe family DN405_07580 ENOG4105CPK Glycosyl transferase (Group 1 DN405_07600 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DN405_07615 ENOG4105DVT helicase DN405_07620 ENOG4105YAC DN405_07640 ENOG4105CSM endonuclease III DN405_07650 ENOG4105BZ4 penicillin-binding protein DN405_07690 ENOG4106F55 Protein of unknown function (DUF1273) DN405_07705 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DN405_07715 ENOG4105DVT helicase DN405_07720 ENOG4105CTD carboxy-peptidase DN405_07730 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DN405_07735 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DN405_07740 ENOG4105C2W permease DN405_07745 ENOG4105DHF Membrane DN405_07750 ENOG410890F Dynamin family DN405_07760 ENOG4108W0I acetyltransferase DN405_07770 ENOG4105KHC sulfurtransferase DN405_07795 ENOG4106032 Glutathionylspermidine synthase DN405_07830 ENOG4105HTX biosynthesis protein DN405_07860 ENOG4105CPK Glycosyl transferase (Group 1 DN405_07875 ENOG4108SZE gCN5-related N-acetyltransferase DN405_07895 ENOG41081VK Ribonuclease DN405_07960 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN405_07970 ENOG4107RWR Sodium hydrogen exchanger DN405_07975 ENOG4105CN5 Metallo-Beta-Lactamase DN405_07980 ENOG4108Z5V transcriptional regulator, merr family DN405_07990 ENOG4105H67 Protein of unknown function (DUF421) DN405_07995 ENOG41080C8 DUF218 domain DN405_08030 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DN405_08040 ENOG4107R0U MotA TolQ exbB proton channel DN405_08045 ENOG4105ER2 Ompa motb domain protein DN405_08050 ENOG4107YTP response regulator receiver protein DN405_08055 ENOG4105CBS Chea signal transduction histidine kinase DN405_08060 ENOG4105DD5 Flagellar motor switch protein DN405_08075 ENOG4105BZU Histidine kinase DN405_08095 ENOG4105E1Q flagellar hook-associated protein DN405_08100 ENOG4105DTJ flagellar hook-associated protein DN405_08120 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DN405_08125 ENOG4108ZC9 flagellar basal-body rod protein flgc DN405_08130 ENOG41075Z6 flagellar hook-basal body complex protein fliE DN405_08135 ENOG4107U2N Flagellar M-ring protein DN405_08140 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN405_08170 ENOG4105BZE flagellar hook protein, FlgE DN405_08185 ENOG4107R88 Chemotaxis protein (CheV) DN405_08195 ENOG4105I03 Flagellin DN405_08200 ENOG4105I03 Flagellin DN405_08205 ENOG4105E4C Lytic transglycosylase catalytic DN405_08215 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DN405_08220 ENOG4105DD5 Flagellar motor switch protein DN405_08230 ENOG4105CN7 Flagellar biosynthetic protein FliP DN405_08235 ENOG4105VS8 Flagellar biosynthetic protein fliq DN405_08245 ENOG4105D00 flagellar biosynthetic protein flhB DN405_08250 ENOG4105D7B Flagellar biosynthesis protein flha DN405_08255 ENOG4105FZW flagellar biosynthesis regulator FlhF DN405_08260 ENOG4105KTQ flagellar basal-body rod protein DN405_08265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN405_08300 ENOG4105KAC Antibiotic biosynthesis monooxygenase DN405_08325 ENOG4105DUM transcriptional regulator, lysR family DN405_08340 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DN405_08345 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DN405_08375 ENOG4105CVJ phosphoglycerate mutase DN405_08385 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DN405_08405 ENOG4105CAQ asparagine synthetase DN405_08425 ENOG4105PGM cation diffusion facilitator family transporter DN405_08435 ENOG4105DRR Transcriptional regulator, GntR family DN405_08440 ENOG4108UZ3 Transporter DN405_08450 ENOG4105CKI cobalamin synthesis protein DN405_08460 ENOG4108PJD permease DN405_08475 ENOG4105DFD Na H antiporter DN405_08480 ENOG4105VUF Transcriptional regulator DN405_08490 ENOG4105C9Q fumarate hydratase class II DN405_08505 ENOG4107QJQ Mate efflux family protein DN405_08510 ENOG4105EC3 peptidase S51, dipeptidase E DN405_08530 ENOG4107QIV Cytochrome c biogenesis protein DN405_08535 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN405_08555 ENOG4106BRA Membrane DN405_08585 ENOG4105WH1 Two component transcriptional regulator luxr family DN405_08595 ENOG4105CJ1 ABC, transporter DN405_08620 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DN405_08630 ENOG4108IJ0 Aspartate ammonia-lyase DN405_08635 ENOG4105C6K Malic enzyme DN405_08695 ENOG4105FVX DN405_08700 ENOG4105E09 nadh pyrophosphatase DN405_08715 ENOG4105CSR polyphosphate kinase 2 DN405_08720 ENOG4105U3E Transcriptional regulator DN405_08735 ENOG4105DXI Major Facilitator superfamily DN405_08745 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN405_08750 ENOG4105EU0 Major facilitator Superfamily DN405_08755 ENOG4105C6T cysteine synthase DN405_08775 ENOG4105C8J )-transporter DN405_08785 ENOG4105X5K response regulator receiver protein DN405_08790 ENOG4105H67 Protein of unknown function (DUF421) DN405_08805 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DN405_08810 ENOG4105CHR reductase DN405_08815 ENOG4105CM2 brancheD-chain amino acid aminotransferase DN405_08820 ENOG4105C7K acetolactate synthase DN405_08830 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DN405_08840 ENOG4105C7B Threonine dehydratase DN405_08865 ENOG4105C6X Major Facilitator DN405_08870 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DN405_08880 ENOG4105DY9 regulatoR DN405_08885 ENOG4105CYC Transferase DN405_08890 ENOG4105K5X acetyltransferase DN405_08910 ENOG41068WN DN405_08930 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DN405_08935 ENOG4105C72 UPF0176 protein DN405_08945 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DN405_08950 ENOG4105C0X amino acid DN405_08995 ENOG410849A acetyltransferase, (GNAT) family DN405_09020 ENOG4107RHR regulatoR DN405_09030 ENOG4105D9N nucleoside DN405_09035 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DN405_09090 ENOG410811B TRANSCRIPTIONal DN405_09105 ENOG4107RAQ aminopeptidase DN405_09115 ENOG4107R16 Multicopper oxidase DN405_09170 ENOG4108T5E Copper resistance protein DN405_09175 ENOG4105KTB nuclear export factor GLE1 DN405_09180 ENOG4107RT3 EamA-like transporter family DN405_09185 ENOG4105GZI Transcriptional regulator DN405_09190 ENOG4108Z40 Transcriptional regulator DN405_09195 ENOG4107ZXU DSBA oxidoreductase DN405_09200 ENOG4108TVJ Nitroreductase DN405_09205 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN405_09210 ENOG4106F5Q Membrane DN405_09215 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN405_09230 ENOG4105CKI cobalamin synthesis protein DN405_09240 ENOG4105C0Z ABC transporter DN405_09245 ENOG4108IV0 ABC, transporter DN405_09250 ENOG4105C32 Amino acid ABC transporter (Permease) DN405_09260 ENOG4105SKE transcriptional Regulator LysR family DN405_09270 ENOG4105MDS 4-oxalocrotonate tautomerase DN405_09285 ENOG4105C4M (Ubiquinol oxidase) subunit I DN405_09290 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN405_09295 ENOG4108JJ9 ABC, transporter DN405_09300 ENOG4108JJ8 (ABC) transporter DN405_09310 ENOG4105K64 Glycosyl transferase, family 2 DN405_09320 ENOG4108UT6 Transferase hexapeptide repeat containing protein DN405_09375 ENOG4105BZ1 (ABC) transporter DN405_09380 ENOG4105EFI regulatoR DN405_09385 ENOG4105BZU Histidine kinase DN405_09395 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DN405_09400 ENOG4108ZJ4 polysaccharide deacetylase DN405_09420 ENOG4105D6E homoserine dehydrogenase DN405_09430 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DN405_09445 ENOG4108KGH TRANSCRIPTIONal DN405_09455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN405_09460 ENOG4105BZU Histidine kinase DN405_09465 ENOG4107VMI polysaccharide deacetylase DN405_09475 ENOG4105KT7 mgtC SapB transporter DN405_09480 ENOG4105VRR gCN5-related N-acetyltransferase DN405_09490 ENOG4105DUU IucA IucC family protein DN405_09495 ENOG4105CEY Amp-dependent synthetase and ligase DN405_09510 ENOG4108WBH protein TIM barrel DN405_09515 ENOG4105YWU small acid-soluble spore protein DN405_09525 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DN405_09530 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN405_09580 ENOG4105KRN Transcriptional regulator, abrb family DN405_09600 ENOG4105KAF membrAne DN405_09625 ENOG4105C8Q Methyl-accepting chemotaxis DN405_09640 ENOG4108K88 Membrane DN405_09645 ENOG4108WPJ Ferritin-like domain DN405_09660 ENOG4105DEN Luciferase family DN405_09675 ENOG4105VMI -acetyltransferase DN405_09680 ENOG4107QM2 Aldo Keto reductase DN405_09690 ENOG4105CKI cobalamin synthesis protein DN405_09700 ENOG4105DSE periplasmic solute binding protein DN405_09705 ENOG4105K4T epimerase DN405_09715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN405_09760 ENOG4107T5V SNARE associated Golgi DN405_09775 ENOG4108PJD permease DN405_09785 ENOG4108S4H thioesterase Superfamily protein DN405_09795 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DN405_09815 ENOG4105SXS Protein of unknown function (DUF456) DN405_09820 ENOG4105C37 (CBS) domain DN405_09840 ENOG4108Z7R Chaperone CsaA DN405_09860 ENOG4108ZRV stage ii sporulation protein p DN405_09870 ENOG4108VXD carboxy-peptidase DN405_09880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DN405_09900 ENOG4108ZRV stage ii sporulation protein p DN405_09910 ENOG4108X4Q Hydrolase DN405_09925 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DN405_09945 ENOG41087PP glycosyltransferase MGT family DN405_09950 ENOG4108JYZ YitT family DN405_09955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN405_09985 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DN405_10005 ENOG4106PAW secretion accessory protein EsaA YueB DN405_10015 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) DN405_10020 ENOG4108MGT Required for secretion of EsxA and EsxB DN405_10075 ENOG4105KBJ sporulation protein ytfj DN405_10100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DN405_10120 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DN405_10125 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DN405_10135 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DN405_10140 ENOG4105EMN RNA polymerase sigma factor DN405_10165 ENOG4108V06 Glutathione peroxidase DN405_10180 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN405_10190 ENOG4108IUE nitrate reductase beta subunit DN405_10195 ENOG4105R3A Nitrate reductase DN405_10205 ENOG4107V6Q Cyclic nucleotide-binding domain DN405_10210 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN405_10215 ENOG4105D06 uba thif-type nad fad binding protein DN405_10220 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN405_10225 ENOG4108ZAF Molybdopterin DN405_10260 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DN405_10265 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DN405_10270 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DN405_10275 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DN405_10280 ENOG4108IFG nitrite reductase, (NAD(P)H) DN405_10285 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DN405_10320 ENOG4105MCT stage V sporulation protein S DN405_10365 ENOG4105C5H ABC transporter DN405_10380 ENOG4108UUM single-stranded DNA-binding protein DN405_10405 ENOG4107YX5 Pfam:DUF548 DN405_10410 ENOG4105C75 arginyL-tRNA synthetase DN405_10435 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN405_10465 ENOG4105C5S asparaginyl-tRNA synthetase DN405_10470 ENOG4105C8J )-transporter DN405_10490 ENOG4107XGZ Hydrolase DN405_10495 ENOG4105CY2 Citrate transporter DN405_10515 ENOG4105KD7 acetyltransferase DN405_10525 ENOG4105VMP Transcriptional regulator DN405_10530 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DN405_10555 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DN405_10570 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DN405_10575 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DN405_10585 ENOG4107RVG penicillin-binding protein DN405_10590 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DN405_10595 ENOG4105E9Q Acyl-transferase DN405_10600 ENOG4108UT2 hemolysin iii DN405_10610 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DN405_10620 ENOG4108RCR degv family DN405_10630 ENOG4108KF3 Electron transport protein SCO1 SenC DN405_10635 ENOG4107Y70 Heat shock protein DN405_10640 ENOG4105CAQ asparagine synthetase DN405_10655 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN405_10660 ENOG4108MES Periplasmic binding protein DN405_10665 ENOG4105F0I Aminotransferase DN405_10700 ENOG4105D8X mechanosensitive ion channel DN405_10705 ENOG4105BZU Histidine kinase DN405_10710 ENOG4105WH1 Two component transcriptional regulator luxr family DN405_10715 ENOG4106KNT transcriptional regulator DN405_10720 ENOG4107ZY0 Phenazine biosynthesis-like protein DN405_10740 ENOG4105CMG Carbohydrate kinase DN405_10745 ENOG4105C6Z Gluconate DN405_10755 ENOG4108YV3 Protein of unknown function (DUF2711) DN405_10785 ENOG4108IJ8 ABC transporter DN405_10790 ENOG4105E90 ABC transporter DN405_10825 ENOG4105C37 (CBS) domain DN405_10850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN405_10865 ENOG4107S4Y M20 DapE family protein YgeY DN405_10870 ENOG4108TSC N-acetyltransferase DN405_10875 ENOG4108JUB Transcriptional regulator DN405_10880 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DN405_10925 ENOG410841Q phosphoesterase PA-phosphatase related protein DN405_10935 ENOG4105SZ6 Thioredoxin DN405_10980 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN405_11035 ENOG4105BZ4 penicillin-binding protein DN405_11045 ENOG4105CZM Major Facilitator DN405_11050 ENOG4105W8X HesB YadR YfhF-family protein DN405_11060 ENOG4105DXD 2-methylcitrate dehydratase DN405_11065 ENOG4105CR4 methylisocitrate lyase DN405_11070 ENOG4105C1G acyl-Coa dehydrogenase DN405_11075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN405_11085 ENOG4105N14 lysine exporter protein LysE YggA DN405_11090 ENOG4105E39 Enoyl-CoA hydratase DN405_11105 ENOG4107RFY SbcCD D subunit DN405_11110 ENOG4105EYH Exonuclease DN405_11135 ENOG4105FCD Major Facilitator DN405_11140 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DN405_11145 ENOG4105E4F Isochorismate synthase DN405_11150 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DN405_11155 ENOG4105WQI isochorismatase DN405_11160 ENOG4105CEY Amp-dependent synthetase and ligase DN405_11165 ENOG4105WQT MbtH domain protein DN405_11170 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN405_11185 ENOG4105K70 DNA-binding protein DN405_11205 ENOG4105BZG amino acid carrier protein DN405_11225 ENOG4105FE9 pseudouridine synthase DN405_11230 ENOG4105C22 threonyL-tRNA synthetase DN405_11235 ENOG4105C19 ABC transporter DN405_11290 ENOG41081I9 integral membrane protein DN405_11300 ENOG4108Y4K DNA-binding transcriptional activator DN405_11310 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) DN405_11320 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DN405_11330 ENOG4105EYF MMPL domain protein DN405_11350 ENOG4105WCN acetyltransferase DN405_11370 ENOG4105C1Q protoporphyrinogen oxidase DN405_11380 ENOG41068WN DN405_11405 ENOG4108KP7 hydrolase DN405_11415 ENOG4107V2S Transcriptional regulator DN405_11420 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN405_11440 ENOG4105DND Transcriptional regulator DN405_11445 ENOG4108RPX mosc domain containing protein DN405_11460 ENOG4105BZ1 (ABC) transporter DN405_11465 ENOG4105BZ1 (ABC) transporter DN405_11495 ENOG4108JCI Transcriptional regulator DN405_11530 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DN405_11535 ENOG4108KPJ rna polymerase sigma factor DN405_11555 ENOG4105F32 YngK protein DN405_11575 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DN405_11580 ENOG4105RD7 BadF BadG BcrA BcrD DN405_11585 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DN405_11595 ENOG4105C7B Threonine dehydratase DN405_11600 ENOG4108INS Transcriptional regulator DN405_11615 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DN405_11625 ENOG4105C1J atp-dependent rna helicase DN405_11715 ENOG4105XSJ toxin secretion phage lysis holin DN405_11720 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DN405_11735 ENOG41088CC tellurite resistance protein tehB DN405_11750 ENOG4107RA9 decarboxylase DN405_11755 ENOG41090HR transcriptional regulator DN405_11760 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DN405_11780 ENOG4105CIN aminoacyl-histidine dipeptidase DN405_11805 ENOG4105KRN Transcriptional regulator, abrb family DN405_11815 ENOG4105EJ9 Membrane DN405_11820 ENOG4105EQK -acetyltransferase DN405_11970 ENOG4105EJQ L-serine dehydratase DN405_11975 ENOG4105C44 Serine transporter DN405_11985 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN405_12010 ENOG4108IG5 Transcriptional regulator DN405_12020 ENOG4105FQP Beta-lactamase DN405_12025 ENOG4107RVG penicillin-binding protein DN405_12040 ENOG4107RF6 penicillin-binding protein DN405_12045 ENOG4107RF6 penicillin-binding protein DN405_12055 ENOG4105DIN metallophosphoesterase DN405_12065 ENOG4105CJ1 ABC, transporter DN405_12075 ENOG4107Z3H Transcriptional regulator, TetR family DN405_12090 ENOG4105C1G acyl-Coa dehydrogenase DN405_12095 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN405_12100 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DN405_12105 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DN405_12110 ENOG4105E39 Enoyl-CoA hydratase DN405_12115 ENOG4107QX3 carboxylase DN405_12120 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN405_12150 ENOG4105DBI uridine monophosphokinase DN405_12175 ENOG4105DZ1 carboxypeptidase DN405_12190 ENOG4105T9C HD domain DN405_12200 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DN405_12220 ENOG41075H3 AraC family transcriptional regulator DN405_12250 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DN405_12260 ENOG4107Y80 Major Facilitator superfamily DN405_12265 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DN405_12275 ENOG4105KVH Transcriptional regulator DN405_12280 ENOG41089UC methyltransferase, type 11 DN405_12330 ENOG4105EFA 4-hydroxyphenylacetate DN405_12345 ENOG4105CPQ Dehydrogenase DN405_12355 ENOG410900G Protein of unknown function (DUF421) DN405_12370 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DN405_12445 ENOG4105D6E homoserine dehydrogenase DN405_12455 ENOG4105CPF Cell wall formation (By similarity) DN405_12460 ENOG4105ETU transcriptional activator (TenA DN405_12490 ENOG4105VTR Integrase DN405_12565 ENOG4105KNA -acetyltransferase DN405_12660 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN405_12740 ENOG4105XSJ toxin secretion phage lysis holin DN405_12835 ENOG410667J hydrolase DN405_12840 ENOG4105BZU Histidine kinase DN405_12845 ENOG4107RF6 penicillin-binding protein DN405_12870 ENOG4108JJB ABC transporter DN405_12885 ENOG4108HGU Histidine kinase DN405_13010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_13015 ENOG4105GR3 Histidine kinase DN405_13020 ENOG4105CB2 alcohol dehydrogenase DN405_13025 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DN405_13030 ENOG4105CJN penicillin-binding protein DN405_13070 ENOG4108V4B ThiJ pfpI DN405_13085 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DN405_13110 ENOG4107Y9U Membrane DN405_13150 ENOG4105FCD Major Facilitator DN405_13160 ENOG4105E09 nadh pyrophosphatase DN405_13165 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DN405_13185 ENOG4108XI2 Domain of unknown function (DUF1963) DN405_13210 ENOG4108NRW Phospholipase, patatin family DN405_13215 ENOG4105KWG Pfam:DUF1696 DN405_13225 ENOG4108YYS metal-dependent hydrolase (By similarity) DN405_13240 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DN405_13250 ENOG4105PKS Excinuclease abc c subunit domain protein DN405_13290 ENOG4107VFR oxidoreductase DN405_13325 ENOG4105PAD Hydrolase DN405_13330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_13335 ENOG4105BZU Histidine kinase DN405_13355 ENOG4107WD8 ABC transporter, permease DN405_13370 ENOG4105DY8 decarboxylase DN405_13385 ENOG4108IUM Glycogen debranching enzyme DN405_13395 ENOG4105CGH 5'-nucleotidase DN405_13415 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DN405_13420 ENOG4105FDR Membrane DN405_13425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DN405_13430 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DN405_13475 ENOG4105MSI germination protein ypeb DN405_13505 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DN405_13510 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DN405_13515 ENOG4107Z3H Transcriptional regulator, TetR family DN405_13540 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DN405_13555 ENOG4105E98 transcriptional regulator DeoR family DN405_13570 ENOG41062ES Transcriptional regulator DN405_13590 ENOG4107QKR Dehydrogenase DN405_13600 ENOG4107RUY (E1 component), alpha subunit DN405_13610 ENOG4105E1F short-chain dehydrogenase reductase DN405_13640 ENOG4107SQ8 Glycine betaine DN405_13645 ENOG4108IJ7 Glycine betaine DN405_13655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN405_13670 ENOG4105E66 phosphoriboisomerase A DN405_13675 ENOG41082BV acetyltransferase DN405_13680 ENOG4108M1A Chitin-binding protein DN405_13710 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN405_13715 ENOG4105MSB protein, conserved in bacteria DN405_13740 ENOG4108Z7F N-acetyltransferase DN405_13760 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DN405_13765 ENOG4105EEM helicase DN405_13780 ENOG4105C9U ATP-dependent DNA helicase RecQ DN405_13835 ENOG4108M1A Chitin-binding protein DN405_13850 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DN405_13860 ENOG4105BZG amino acid carrier protein DN405_13865 ENOG4105C26 Dehydrogenase DN405_13870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN405_13875 ENOG4105CTU Proline racemase DN405_13880 ENOG4105CTU Proline racemase DN405_13885 ENOG41080HI glycine oxidase DN405_13895 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DN405_13925 ENOG4107T5V SNARE associated Golgi DN405_13935 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DN405_13955 ENOG4105DTQ mandelate racemase muconate lactonizing DN405_13970 ENOG4107SET aldo keto reductase DN405_14005 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DN405_14010 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DN405_14015 ENOG4105BZU Histidine kinase DN405_14020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_14040 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 DN405_14055 ENOG4105DPN Oligoendopeptidase f DN405_14060 ENOG4105EPR degv family DN405_14120 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DN405_14125 ENOG4106K7D Major facilitator family transporter DN405_14145 ENOG4107BMA Transglycosylase associated protein DN405_14160 ENOG41089UC methyltransferase, type 11 DN405_14195 ENOG4105CHM Aminotransferase DN405_14210 ENOG4108ZMI UPF0477 protein DN405_14250 ENOG4105C02 permease DN405_14260 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DN405_14265 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DN405_14270 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DN405_14275 ENOG4105D7T ABC transporter DN405_14310 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DN405_14360 ENOG4107VC0 DNA alkylation repair enzyme DN405_14365 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DN405_14375 ENOG4107VMI polysaccharide deacetylase DN405_14385 ENOG4108ZCF integral membrane protein DN405_14390 ENOG4105E0M Sulfatase DN405_14395 ENOG4105C5H ABC transporter DN405_14400 ENOG4105EYF MMPL domain protein DN405_14405 ENOG41082JN Transcriptional regulator DN405_14425 ENOG4105CIH Imidazole acetol-phosphate transaminase DN405_14430 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DN405_14435 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN405_14485 ENOG41069ER domain protein DN405_14495 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DN405_14500 ENOG4105DNP FAD linked oxidase domain protein DN405_14525 ENOG4105D4B ABC, transporter DN405_14530 ENOG4105F5R ABC transporter DN405_14535 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DN405_14545 ENOG4105DKT Transcriptional regulator DN405_14550 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DN405_14560 ENOG41061GT Aldolase DN405_14570 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DN405_14605 ENOG4105II7 pyrroline-5-carboxylate reductase DN405_14615 ENOG4107258 Transcriptional regulator DN405_14635 ENOG4105ECK Fatty Acid Desaturase DN405_14645 ENOG4107RBI VanW family DN405_14650 ENOG4105G6Z alkaline phosphatase DN405_14660 ENOG4105VMP Transcriptional regulator DN405_14675 ENOG41090T1 Membrane DN405_14685 ENOG4108WCX response regulator DN405_14695 ENOG41068WN DN405_14730 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN405_14755 ENOG4105CKK Glycosyl transferase, family 2 DN405_14785 ENOG4105C8Y Acetylornithine aminotransferase DN405_14830 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DN405_14855 ENOG4108IBT Inherit from COG: transposase DN405_14875 ENOG4108TVJ Nitroreductase DN405_14880 ENOG4105FS7 Transcriptional regulator DN405_14905 ENOG4105WEC Molybdate metabolism regulator DN405_14925 ENOG4108DMH HTH_ARAC DN405_14930 ENOG4108XET gCN5-related N-acetyltransferase DN405_14945 ENOG4108PCN EamA-like transporter family DN405_14955 ENOG4107XJU UPF0178 protein DN405_14990 ENOG410635A Membrane DN405_15000 ENOG4108IQI permease DN405_15010 ENOG4105F1N DNA alkylation repair DN405_15070 ENOG4107RF6 penicillin-binding protein DN405_15075 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DN405_15095 ENOG4105E7W lamb ycsf family protein DN405_15105 ENOG4105P4J Allophanate hydrolase, subunit 1 DN405_15110 ENOG4107258 Transcriptional regulator DN405_15120 ENOG4106N3A copper homeostasis protein cutc DN405_15125 ENOG4108ZHR arsR family transcriptional regulator DN405_15135 ENOG4105FDT acyl-CoA dehydrogenase DN405_15150 ENOG4105DWD nucleoside recognition domain protein DN405_15195 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DN405_15220 ENOG4105E2A Dehydrogenase DN405_15225 ENOG4108IJ0 Aspartate ammonia-lyase DN405_15230 ENOG4105HDK L-asparaginase DN405_15235 ENOG4108IMY Transcriptional regulator DN405_15260 ENOG4108B31 Spore germination protein DN405_15270 ENOG4105BZU Histidine kinase DN405_15295 ENOG41075H3 AraC family transcriptional regulator DN405_15315 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DN405_15320 ENOG4105CUB amino acid DN405_15325 ENOG4105II7 pyrroline-5-carboxylate reductase DN405_15330 ENOG4108NHD germination protein DN405_15335 ENOG4108Q8B Spore germination protein DN405_15355 ENOG4105CSV Glutaminase DN405_15390 ENOG4105CGH 5'-nucleotidase DN405_15400 ENOG4105CHJ isochorismatase hydrolase DN405_15425 ENOG41090MY MarR family Transcriptional regulator DN405_15450 ENOG4105F6J Alpha beta hydrolase fold DN405_15465 ENOG4108606 TspO/MBR family DN405_15470 ENOG4105CVP deoxyribo-dipyrimidine photolyase DN405_15495 ENOG4108TWJ NADH dehydrogenase subunit 5 DN405_15500 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DN405_15505 ENOG4107VMI polysaccharide deacetylase DN405_15510 ENOG4105KY5 gCN5-related N-acetyltransferase DN405_15515 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN405_15530 ENOG4105NAE bifunctional deaminase-reductase domain protein DN405_15555 ENOG4107P5I polyketide synthase DN405_15560 ENOG4108IG5 Transcriptional regulator DN405_15565 ENOG4105F27 Major Facilitator DN405_15570 ENOG4105M4P Tetr family transcriptional regulator DN405_15575 ENOG4105CHR reductase DN405_15580 ENOG4108YXU transcriptional regulator AsnC family DN405_15610 ENOG4105N0V mono-oxygenase ydhR DN405_15645 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DN405_15650 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN405_15665 ENOG4105K6H D-cysteine desulfhydrase DN405_15675 ENOG4105E0Y RtcB Protein DN405_15685 ENOG4105JQZ Methyltransferase DN405_15705 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DN405_15725 ENOG4105BZU Histidine kinase DN405_15735 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DN405_15745 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DN405_15770 ENOG4108JQ1 Dehydrogenase DN405_15775 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DN405_15815 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN405_15920 ENOG4108VXD carboxy-peptidase DN405_15925 ENOG4105PNM synthesis protein DN405_15935 ENOG4108ISG Major Facilitator DN405_15950 ENOG4107MII Sugar-specific transcriptional regulator TrmB DN405_15955 ENOG4105CZM Major Facilitator DN405_15965 ENOG4105CRW Short chain fatty acid transporter DN405_15975 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN405_16035 ENOG4108K8S endonuclease I DN405_16060 ENOG4108Z66 YbaK ebsC protein DN405_16065 ENOG4105CUT histidyl-tRNA synthetase DN405_16080 ENOG4105KVH Transcriptional regulator DN405_16085 ENOG4108RCM Nitroreductase DN405_16115 ENOG4108PSK reductase DN405_16190 ENOG4105C31 Tryptophanyl-tRNA synthetase DN405_16225 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) DN405_16265 ENOG4105C37 (CBS) domain DN405_16280 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DN405_16285 ENOG4105FAW cDP-glucose 4,6-dehydratase DN405_16320 ENOG4105DDN Pentapeptide repeat-containing protein DN405_16325 ENOG4105XDF Protein of unknown function (DUF1272) DN405_16330 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DN405_16335 ENOG4105CMG Carbohydrate kinase DN405_16340 ENOG4105C6Z Gluconate DN405_16345 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DN405_16360 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DN405_16365 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DN405_16375 ENOG4105CIS alcohol dehydrogenase DN405_16380 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DN405_16390 ENOG4105PDP Short chain dehydrogenase DN405_16400 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DN405_16415 ENOG4105C8Q Methyl-accepting chemotaxis DN405_16420 ENOG4108UX3 '-nucleotidase DN405_16425 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DN405_16430 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DN405_16435 ENOG4105KVH Transcriptional regulator DN405_16450 ENOG4105CV8 reductase DN405_16455 ENOG4105F27 Major Facilitator DN405_16465 ENOG41090KN UPF0303 protein DN405_16480 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DN405_16485 ENOG4105CHH sulfate transporter DN405_16500 ENOG4105C44 Serine transporter DN405_16535 ENOG4105KVH Transcriptional regulator DN405_16540 ENOG4108TZY GntR Family Transcriptional Regulator DN405_16545 ENOG4105D9R oxidoreductase DN405_16550 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DN405_16555 ENOG4105KVH Transcriptional regulator DN405_16560 ENOG4105KVH Transcriptional regulator DN405_16605 ENOG4105JAB phenazine biosynthesis protein, phzf family DN405_16615 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DN405_16620 ENOG4105KVH Transcriptional regulator DN405_16630 ENOG4108ZJ4 polysaccharide deacetylase DN405_16655 ENOG4105W1N transcriptional regulator DN405_16660 ENOG4105CVK Glutamate decarboxylase DN405_16730 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DN405_16760 ENOG4105H3G oxidoreductase DN405_16840 ENOG4108TN2 lmbE family DN405_16850 ENOG4107R3E Citrate transporter DN405_16860 ENOG4105WCN acetyltransferase DN405_16865 ENOG4108MES Periplasmic binding protein DN405_16870 ENOG4105EHG Permease protein DN405_16875 ENOG4105DQ5 transport system permease protein DN405_16880 ENOG4105NX3 Membrane DN405_16900 ENOG41068WN DN405_16905 ENOG4107CUJ Protein of unknown function (DUF2690) DN405_16915 ENOG4107V2S Transcriptional regulator DN405_16935 ENOG4105C98 muts2 protein DN405_16940 ENOG4105E5K Alpha-amylase DN405_16945 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DN405_16950 ENOG4105DPN Oligoendopeptidase f DN405_16975 ENOG4105FFC UPF0187 protein DN405_16995 ENOG4108A04 Beta-lactamase DN405_17020 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DN405_17030 ENOG41082BM Transcriptional regulator, arsr family DN405_17035 ENOG4105CB2 alcohol dehydrogenase DN405_17040 ENOG4105CNG UPF0061 protein DN405_17060 ENOG4105CQB FAD linked oxidase domain protein DN405_17085 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DN405_17095 ENOG4107TPS domain protein DN405_17100 ENOG4105CEP NADH dehydrogenase DN405_17110 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DN405_17120 ENOG4108IAJ Nad-dependent epimerase dehydratase DN405_17125 ENOG4105FAW cDP-glucose 4,6-dehydratase DN405_17130 ENOG4105D7V transposase DN405_17165 ENOG41067SE Tetr family transcriptional regulator DN405_17170 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity DN405_17180 ENOG4107DUR UPF0457 protein DN405_17200 ENOG4105BZU Histidine kinase DN405_17210 ENOG4105KT7 mgtC SapB transporter DN405_17220 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN405_17225 ENOG41073R8 VanW family DN405_17235 ENOG4108R1P DN405_17250 ENOG4105VEQ Cold shock protein DN405_17270 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DN405_17290 ENOG410904N short-chain dehydrogenase reductase DN405_17300 ENOG4106IQC argininosuccinate lyase DN405_17315 ENOG4108IA2 Sodium pantothenate symporter DN405_17325 ENOG4105C26 Dehydrogenase DN405_17330 ENOG4105CHR reductase DN405_17340 ENOG4105EWU Squalene--hopene cyclase DN405_17350 ENOG4105FR1 rard protein DN405_17355 ENOG410696E Membrane DN405_17370 ENOG4105D1F ATP-binding protein DN405_17380 ENOG4108ZAF Molybdopterin DN405_17385 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN405_17390 ENOG4105D06 uba thif-type nad fad binding protein DN405_17395 ENOG4105TMB Formate nitrite transporter DN405_17405 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DN405_17410 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DN405_17420 ENOG4108JB9 formate dehydrogenase DN405_17425 ENOG4105E1K spore germination protein DN405_17440 ENOG4105CUB amino acid DN405_17495 ENOG4107QJT sodium dicarboxylate symporter DN405_17500 ENOG4108KGH TRANSCRIPTIONal DN405_17510 ENOG4105EMN RNA polymerase sigma factor DN405_17520 ENOG4105CIG ABC transporter DN405_17530 ENOG4105D9R oxidoreductase DN405_17540 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DN405_17545 ENOG4105K4P CoA-binding domain protein DN405_17550 ENOG4105C0H protease DN405_17555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_17565 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DN405_17570 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DN405_17575 ENOG4105W8X HesB YadR YfhF-family protein DN405_17605 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN405_17610 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DN405_17620 ENOG4108JJA ABC, transporter DN405_17625 ENOG4108I0Z Aconitate hydratase DN405_17655 ENOG4105E5W Transporter DN405_17665 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN405_17685 ENOG4107F3J Amp-dependent synthetase and ligase DN405_17690 ENOG4107ZYJ bioY protein DN405_17695 ENOG4105CEY Amp-dependent synthetase and ligase DN405_17725 ENOG4105D9G High-affinity DN405_17730 ENOG4105IW1 AmiS UreI transporter DN405_17745 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DN405_17785 ENOG4107AYK membrAne DN405_17800 ENOG4105BZU Histidine kinase DN405_17805 ENOG4105FBA Phospholipase Carboxylesterase DN405_17810 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DN405_17815 ENOG4105CK7 Sodium proline symporter DN405_17825 ENOG4105CBC glutamate synthase DN405_17830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DN405_17835 ENOG4108VJ1 Transcriptional regulator (CarD family DN405_17840 ENOG4108903 Formimidoylglutamase DN405_17900 ENOG4107QIV Cytochrome c biogenesis protein DN405_17915 ENOG4105CH2 amidohydrolase DN405_17925 ENOG4105CJ1 ABC, transporter DN405_17940 ENOG4107RSM transcriptional regulator DN405_17945 ENOG4105VAW lrga family DN405_17950 ENOG41067MG lrgb family DN405_17990 ENOG4105BZ1 (ABC) transporter DN405_17995 ENOG4105BZ1 (ABC) transporter DN405_18030 ENOG4108HW3 (ABC) transporter DN405_18035 ENOG4105CGH 5'-nucleotidase DN405_18045 ENOG4108SVB resolvase DN405_18065 ENOG4105K7K Transcriptional regulator DN405_18075 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DN405_18080 ENOG4105DR5 peptidase DN405_18085 ENOG41065S2 pneumococcal vaccine antigen DN405_18115 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DN405_18120 ENOG4105C5F glutamine synthetase DN405_18125 ENOG4105KV4 Transcriptional regulator DN405_18130 ENOG4105CXI aluminum resistance protein DN405_18135 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DN405_18140 ENOG4105EN6 Membrane DN405_18145 ENOG4106F1P AAA ATPase, central domain protein DN405_18175 ENOG41069ER domain protein DN405_18180 ENOG4105DM4 PTS System DN405_18185 ENOG4105DE4 1-phosphofructokinase DN405_18190 ENOG4105E98 transcriptional regulator DeoR family DN405_18195 ENOG4107QW4 alcohol dehydrogenase DN405_18200 ENOG4108SJC Membrane DN405_18210 ENOG4105C85 amino acid DN405_18230 ENOG4105TMB Formate nitrite transporter DN405_18235 ENOG4105K70 DNA-binding protein DN405_18245 ENOG4105C59 p-type ATPase DN405_18250 ENOG410681U heavy metal transport detoxification protein DN405_18255 ENOG4105VPX protein, conserved in bacteria DN405_18265 ENOG4105NIV Esterase DN405_18270 ENOG4105E0A ABC, transporter DN405_18305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DN405_18310 ENOG4105D03 DNA-3-methyladenine glycosylase II DN405_18340 ENOG4105BZU Histidine kinase DN405_18380 ENOG41067MG lrgb family DN405_18400 ENOG4107YEI lmbE family DN405_18420 ENOG4105F0V Cell wall hydrolase DN405_18435 ENOG4105E0M Sulfatase DN405_18440 ENOG410890F Dynamin family DN405_18475 ENOG4105DQU oxidoreductase, subunit beta DN405_18480 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DN405_18485 ENOG4108IGT Dipeptidase DN405_18490 ENOG4105MCT stage V sporulation protein S DN405_18495 ENOG4105D48 metallophosphoesterase DN405_18515 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DN405_18530 ENOG4105XZV Protein of unknown function (DUF3243) DN405_18535 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DN405_18555 ENOG4105UIB (ABC) transporter DN405_18560 ENOG4108JQ9 ABC transporter DN405_18565 ENOG4105DIH basic membrane DN405_18570 ENOG4105FDP GntR family transcriptional regulator DN405_18580 ENOG4105CNU cell division protein FtsK DN405_18590 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DN405_18600 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DN405_18610 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DN405_18615 ENOG4108S0H Dipicolinic acid synthetase, b subunit DN405_18620 ENOG4105E35 Dipicolinate synthase subunit A DN405_18630 ENOG4105C1V Peptidase, M16 DN405_18650 ENOG4105DTN riboflavin biosynthesis protein ribF DN405_18665 ENOG4105W7A Protein of unknown function (DUF503) DN405_18675 ENOG4105VHM ribosomal protein DN405_18680 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DN405_18685 ENOG4105CHV Transcription elongation factor NusA DN405_18695 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DN405_18705 ENOG4105DZP Membrane-associated zinc metalloprotease DN405_18710 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DN405_18715 ENOG4105KNE Phosphatidate cytidylyltransferase DN405_18720 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DN405_18730 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DN405_18760 ENOG4108HE4 integrase family DN405_18770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DN405_18775 ENOG4105C79 DNA protecting protein DprA DN405_18780 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DN405_18795 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DN405_18820 ENOG4105VB6 UPF0109 protein DN405_18840 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DN405_18845 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DN405_18860 ENOG4105CHR reductase DN405_18865 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DN405_18880 ENOG4105CB5 ATP-dependent DNA helicase recG DN405_18885 ENOG4105DP4 dak2 domain fusion protein ylov DN405_18890 ENOG4108ZAA Alkaline-shock protein DN405_18905 ENOG4105FJ0 thiamine DN405_18910 ENOG4105DJV ribulose-phosphate 3-epimerase DN405_18915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DN405_18920 ENOG4105D9P serine threonine protein kinase DN405_18925 ENOG4108ZF3 Phosphatase DN405_18935 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DN405_18950 ENOG4105C25 Primosomal protein n' DN405_18955 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DN405_18975 ENOG4105DSJ YicC domain protein DN405_18985 ENOG4105F23 Fibronectin-binding protein DN405_18990 ENOG4105DC7 peptidase M24 DN405_19015 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DN405_19030 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DN405_19035 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DN405_19045 ENOG4105CD3 dihydroorotase DN405_19065 ENOG4105C34 Pseudouridine synthase DN405_19080 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DN405_19090 ENOG4105DBK s4 domain protein DN405_19095 ENOG41067XK integral membrane protein DN405_19105 ENOG4105DFA alanine racemase domain protein DN405_19110 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DN405_19115 ENOG4105WR5 sporulation protein, YlmC YmxH family DN405_19125 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN405_19135 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DN405_19140 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DN405_19150 ENOG4105D4A Cell wall formation (By similarity) DN405_19155 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN405_19160 ENOG4105CNI cell division protein FtsW DN405_19175 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DN405_19180 ENOG4105CJN penicillin-binding protein DN405_19185 ENOG4105CJN penicillin-binding protein DN405_19200 ENOG41074B2 UPF0747 protein DN405_19225 ENOG4105KNH Nucleic acid-binding protein DN405_19235 ENOG41063PX domain protein DN405_19240 ENOG4105D78 K07001 NTE family protein DN405_19245 ENOG4105H20 Sporulation integral membrane protein YlbJ DN405_19255 ENOG4106H78 methyltransferase DN405_19275 ENOG4107TB6 phosphoglycerate mutase DN405_19290 ENOG4106UY4 Inherit from COG: Scp-like extracellular DN405_19340 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DN405_19350 ENOG4105CNI cell division protein FtsW DN405_19365 ENOG4108IAB Phoh family DN405_19385 ENOG4105QA2 DN405_19390 ENOG4105CI3 gtp-binding protein typa DN405_19400 ENOG4105ECY inositol monophosphatase DN405_19420 ENOG4105CXN decarboxylase DN405_19470 ENOG4105CPP Dehydrogenase, E1 component DN405_19485 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DN405_19490 ENOG4108X4Q Hydrolase DN405_19505 ENOG4105CN5 Metallo-Beta-Lactamase DN405_19510 ENOG4107ZYR domain protein DN405_19545 ENOG4108XRC Protein of unknown function (DUF458) DN405_19550 ENOG4107IN1 Protein of unknown function (DUF1797) DN405_19565 ENOG4105EPM Diguanylate phosphodiesterase DN405_19570 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DN405_19585 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DN405_19595 ENOG4105UIN DN405_19630 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DN405_19650 ENOG4108HGU Histidine kinase DN405_19660 ENOG4105CHM Aminotransferase DN405_19665 ENOG4105FKQ transcriptional regulator DN405_19670 ENOG4105EG2 ABC transporter, permease DN405_19680 ENOG4107FKK extracellular solute-binding protein family 1 DN405_19690 ENOG4105CG3 alpha amylase, catalytic region DN405_19735 ENOG4105CHU acetyl-coa acetyltransferase DN405_19770 ENOG4105K7K Transcriptional regulator DN405_19775 ENOG4105DTD Dehydrogenase DN405_19795 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DN405_19820 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DN405_19835 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DN405_19845 ENOG4105BZU Histidine kinase DN405_19865 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DN405_19880 ENOG4105CID antiterminator DN405_19890 ENOG4105FDP GntR family transcriptional regulator DN405_19900 ENOG4105CE4 GlcNAc 6-P deacetylase DN405_19940 ENOG4107ZE5 PPIases accelerate the folding of proteins DN405_19945 ENOG4105PTM secreted protein DN405_19950 ENOG4105J7I hydrolase DN405_19960 ENOG4105G6R Stage v sporulation protein ae DN405_19970 ENOG4105CZ3 stage V sporulation protein ad DN405_19975 ENOG41090VF Stage v sporulation protein ac DN405_19995 ENOG4105C8J )-transporter DN405_20000 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN405_20010 ENOG41082AN stage II sporulation protein DN405_20015 ENOG4105DZ1 carboxypeptidase DN405_20025 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN405_20030 ENOG4105DVE abc transporter atp-binding protein DN405_20065 ENOG4105D7N magnesium and cobalt transport protein CorA DN405_20090 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DN405_20100 ENOG4105I3K Ferric uptake regulator, Fur family DN405_20105 ENOG4105MZ9 stage II sporulation protein m DN405_20125 ENOG4105CPC Aldo Keto reductase DN405_20135 ENOG4105RHY Pfam:UPF0157 DN405_20155 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DN405_20165 ENOG4105ETE Transcriptional regulator (LacI family DN405_20170 ENOG4108YM7 Gcn5-related n-acetyltransferase DN405_20190 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DN405_20195 ENOG4108R6K riboflavin synthase, subunit alpha DN405_20220 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN405_20225 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DN405_20240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DN405_20250 ENOG4105DFD Na H antiporter DN405_20255 ENOG4105CGH 5'-nucleotidase DN405_20280 ENOG4105DBV ornithine carbamoyltransferase DN405_20295 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DN405_20310 ENOG4108IXY short-chain dehydrogenase reductase DN405_20315 ENOG41069FQ Metallo-beta-lactamase superfamily DN405_20320 ENOG4105II7 pyrroline-5-carboxylate reductase DN405_20325 ENOG4105EJQ L-serine dehydratase DN405_20340 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DN405_20355 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DN405_20370 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DN405_20375 ENOG4105D9U N-acetyltransferase DN405_20385 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DN405_20390 ENOG4108QEG Membrane DN405_20395 ENOG4105CDA abc transporter atp-binding protein DN405_20400 ENOG4105E5Q amino acid AbC transporter DN405_20405 ENOG4108HW3 (ABC) transporter DN405_20415 ENOG4105G7B Protein of unknown function (DUF2992) DN405_20425 ENOG4108QY0 Membrane DN405_20435 ENOG4105C7S Dehydrogenase DN405_20440 ENOG4105CPP Dehydrogenase, E1 component DN405_20455 ENOG4105CKM Branched-chain carboxylic acid kinase DN405_20460 ENOG4107RDP Dehydrogenase DN405_20475 ENOG4108JUB Transcriptional regulator DN405_20485 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN405_20500 ENOG4107QQR Sporulation DN405_20510 ENOG4105S1Z Stage IV sporulation protein B DN405_20515 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DN405_20520 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DN405_20525 ENOG4105DX0 Hemolysin A DN405_20535 ENOG4105CTB Polyprenyl synthetase DN405_20550 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DN405_20560 ENOG4108ZSR alkaline shock protein DN405_20565 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DN405_20590 ENOG410644B Stage III sporulation protein af DN405_20600 ENOG4105KQ4 Stage iii sporulation protein ad DN405_20605 ENOG4108CQH stage III sporulation protein AC DN405_20610 ENOG4105KR5 Stage iii sporulation protein DN405_20615 ENOG4105CD2 stage iii sporulation protein aa DN405_20640 ENOG4105DC7 peptidase M24 DN405_20645 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DN405_20655 ENOG4105CBJ Metal-dependent enzyme DN405_20665 ENOG4107YBY Hydrolase DN405_20680 ENOG4105K7K Transcriptional regulator DN405_20695 ENOG41082GG biotin lipoate A B protein ligase DN405_20700 ENOG4105WZW rhodanese family DN405_20725 ENOG41080TC multidrug resistance protein DN405_20755 ENOG4105CJ1 ABC, transporter DN405_20760 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DN405_20775 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DN405_20795 ENOG4105C0D helicase DN405_20845 ENOG4107UNZ domain protein DN405_20880 ENOG41063R6 DN405_20940 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DN405_20945 ENOG4105C3R Methionine synthase DN405_20955 ENOG4105C28 cystathionine DN405_20960 ENOG4105C28 cystathionine DN405_20980 ENOG4105C5X domain protein DN405_20990 ENOG4105DKQ ROK family DN405_21000 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DN405_21015 ENOG4108UTW Plays a role in the regulation of phosphate uptake DN405_21020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DN405_21025 ENOG4105C8U phosphate abc transporter DN405_21030 ENOG4105C8U phosphate abc transporter DN405_21035 ENOG4105EXS phosphate abc transporter DN405_21040 ENOG4107RF6 penicillin-binding protein DN405_21050 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN405_21075 ENOG4105N80 Ferric uptake regulator, Fur family DN405_21085 ENOG4105FDK ABC transporter DN405_21090 ENOG4108JYZ YitT family DN405_21095 ENOG41069ZM Protein of unknown function (DUF2624) DN405_21120 ENOG4105EGD dinuclear metal center protein, YbgI family DN405_21135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN405_21140 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DN405_21165 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DN405_21170 ENOG4105KG3 cytidine deaminase DN405_21175 ENOG4107YR5 Diacylglycerol kinase DN405_21180 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DN405_21185 ENOG4105CTJ Metal Dependent Phosphohydrolase DN405_21190 ENOG4105C9A Phoh family DN405_21200 ENOG41068P3 sporulation protein YqfC DN405_21210 ENOG4105KTH gatB Yqey DN405_21225 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DN405_21230 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DN405_21260 ENOG4105CSA Coproporphyrinogen iii oxidase DN405_21265 ENOG4105KVH Transcriptional regulator DN405_21290 ENOG4105TQK DNA polymerase iii, delta' subunit DN405_21300 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DN405_21305 ENOG4108UK2 deaminase DN405_21310 ENOG4105KQC Competence protein DN405_21320 ENOG4105DXX methyltransferase DN405_21330 ENOG4108WF2 Metal Dependent Phosphohydrolase DN405_21340 ENOG410812S Rna-binding protein DN405_21350 ENOG4105CQW ribosome biogenesis GTPase YqeH DN405_21355 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DN405_21370 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN405_21390 ENOG4108TVJ Nitroreductase DN405_21405 ENOG4105G6Z alkaline phosphatase DN405_21410 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DN405_21415 ENOG4108MUZ hydrolase DN405_21450 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DN405_21455 ENOG4105MIR Phenylalanine 4-monooxygenase DN405_21465 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DN405_21505 ENOG4105S6R Iron-hydroxamate transporter permease subunit DN405_21510 ENOG4108V5C ABC transporter DN405_21525 ENOG4108EKI Dehydrogenase DN405_21530 ENOG4105C28 cystathionine DN405_21560 ENOG4107XRG penicillin-binding protein DN405_21570 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DN405_21580 ENOG4105CFP Peptidase U32 DN405_21585 ENOG4105XYU peptidase (U32 family) DN405_21590 ENOG4108VQJ O-methyltransferase DN405_21595 ENOG4105HHA aminodeoxychorismate lyase DN405_21615 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DN405_21625 ENOG4105C02 permease DN405_21640 ENOG41060CR DN405_21645 ENOG4105C7H Helicase, RecD TraA family DN405_21655 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DN405_21660 ENOG4105C3J Cysteine desulfurase DN405_21670 ENOG4105D1H recombination factor protein RarA DN405_21675 ENOG4108VCI transcription factor, rsfa family DN405_21690 ENOG4105CUZ uba thif-type nad fad binding protein DN405_21700 ENOG4105CUT histidyl-tRNA synthetase DN405_21705 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DN405_21710 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DN405_21720 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DN405_21725 ENOG41076HS cation diffusion facilitator family transporter DN405_21730 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DN405_21740 ENOG4105CKP Polysaccharide Biosynthesis Protein DN405_21745 ENOG4108QG2 Membrane DN405_21755 ENOG4105VIE preprotein translocase, subunit YajC DN405_21770 ENOG41061AI Protein of unknown function (DUF2905) DN405_21785 ENOG4108HUF Transporter DN405_21815 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DN405_21820 ENOG4108IYU L-aspartate oxidase DN405_21835 ENOG4108RPX mosc domain containing protein DN405_21840 ENOG4105CQC Prephenate dehydratase DN405_21855 ENOG4105C19 ABC transporter DN405_21860 ENOG4105EWM Histidine kinase DN405_21870 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DN405_21885 ENOG4105X36 (ribosomal) protein DN405_21895 ENOG4105C03 ribonuclease DN405_21910 ENOG4107QMS site-determining protein DN405_21925 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DN405_21930 ENOG4105DFF Rod shape-determining protein mreb DN405_21950 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DN405_21955 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DN405_21965 ENOG41068KH stage VI sporulation protein D DN405_21975 ENOG4105D52 delta-aminolevulinic acid dehydratase DN405_22000 ENOG4105K56 Transcriptional regulator DN405_22020 ENOG4108IUQ atp-dependent protease DN405_22045 ENOG4108QCI YvbH-like oligomerisation region DN405_22065 ENOG4105M59 Phosphodiesterase, mj0936 family DN405_22070 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DN405_22080 ENOG4108XJQ germination protein DN405_22095 ENOG4105PFC Transcriptional regulator DN405_22105 ENOG4105DZC cytosine deaminase DN405_22110 ENOG41067S9 phage shock protein C, PspC DN405_22115 ENOG4108JCI Transcriptional regulator DN405_22125 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DN405_22130 ENOG4108Z40 Transcriptional regulator DN405_22135 ENOG4105RHA ABC transporter, permease DN405_22140 ENOG4108IUX (ABC) transporter DN405_22145 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DN405_22150 ENOG4105ER2 Ompa motb domain protein DN405_22155 ENOG4105E14 MotA TolQ exbB proton channel DN405_22165 ENOG4108VXD carboxy-peptidase DN405_22175 ENOG4105E33 succinate dehydrogenase DN405_22185 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DN405_22195 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DN405_22200 ENOG4105K63 Thioredoxin DN405_22205 ENOG4105C10 Electron transfer flavoprotein DN405_22210 ENOG4105BZJ Electron transfer flavoprotein DN405_22215 ENOG41060WC Enoyl-CoA hydratase DN405_22220 ENOG4107Z3H Transcriptional regulator, TetR family DN405_22225 ENOG4105CEY Amp-dependent synthetase and ligase DN405_22235 ENOG4105J76 Periplasmic binding protein DN405_22240 ENOG4105S6R Iron-hydroxamate transporter permease subunit DN405_22290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN405_22300 ENOG4105DR4 Methyltransferase DN405_22310 ENOG4105KFN sortase, SrtB family DN405_22315 ENOG4105E0A ABC, transporter DN405_22330 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DN405_22340 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DN405_22350 ENOG4105FE9 pseudouridine synthase DN405_22360 ENOG4105DCG PHP domain protein DN405_22375 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DN405_22390 ENOG4105C5S asparaginyl-tRNA synthetase DN405_22395 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DN405_22405 ENOG4108RWN rrna methyltransferase DN405_22425 ENOG4105C0R drug resistance transporter emrb qaca subfamily DN405_22430 ENOG4105CW7 secretion protein, HlyD family DN405_22435 ENOG4108JGH Tetr family transcriptional regulator DN405_22440 ENOG4105CN9 Peptidase m42 family protein DN405_22460 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DN405_22465 ENOG4105C22 threonyL-tRNA synthetase DN405_22470 ENOG4108TDW sporulation protein YtxC DN405_22495 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DN405_22500 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DN405_22505 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DN405_22515 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DN405_22520 ENOG4105C2M dna polymerase I DN405_22525 ENOG4105BZU Histidine kinase DN405_22530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN405_22545 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN405_22550 ENOG4108HMX isocitrate dehydrogenase (NADP) DN405_22555 ENOG4105BZN citrate synthase DN405_22570 ENOG4108REF Sporulation integral membrane protein ytvi DN405_22575 ENOG4105FS0 cytoplasmic membrane protein DN405_22600 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DN405_22605 ENOG4105C6K Malic enzyme DN405_22610 ENOG4105C0B DNA polymerase III (alpha subunit) DN405_22615 ENOG4105VV2 DN405_22625 ENOG4105SFS phosphoesterase RecJ domain protein DN405_22645 ENOG4105E8R UPF0173 metal-dependent hydrolase DN405_22650 ENOG4105DC7 peptidase M24 DN405_22685 ENOG4105Z7P Acetyltransferase (GNAT) family DN405_22690 ENOG41082W1 Cupin 2, conserved barrel domain protein DN405_22710 ENOG4107YZX Universal stress protein DN405_22750 ENOG4108JYZ YitT family DN405_22770 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DN405_22780 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DN405_22785 ENOG4105KBJ sporulation protein ytfj DN405_22800 ENOG4105EFZ amidohydrolase DN405_22810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DN405_22835 ENOG4105RQF LysR family Transcriptional regulator DN405_22845 ENOG4105U5Y Transcriptional regulator DN405_22855 ENOG4105C28 cystathionine DN405_22885 ENOG4108UW5 maltose o-acetyltransferase DN405_22895 ENOG4105F1V Acetoin utilization protein DN405_22900 ENOG4105W87 Cbs domain DN405_22905 ENOG4105DGU Histone deacetylase DN405_22920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DN405_22930 ENOG4107SNB ankyrin repeat protein YahD DN405_22935 ENOG4105EP9 oxidoreductase DN405_22965 ENOG4105ETE Transcriptional regulator (LacI family DN405_22970 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DN405_22990 ENOG4105C88 aminopeptidase DN405_23025 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DN405_23035 ENOG4108VDD TRNA binding domain protein DN405_23065 ENOG4105C8F Beta-lactamase domain protein DN405_23080 ENOG4108V15 phosphotransferase enzyme family DN405_23085 ENOG4108IUM Glycogen debranching enzyme DN405_23095 ENOG4107QSE Dipeptidase DN405_23100 ENOG4105YW5 deoR family transcriptional regulator DN405_23115 ENOG4105CBX hi0933 family DN405_23155 ENOG4108VJ1 Transcriptional regulator (CarD family DN405_23160 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DN405_23165 ENOG4105CSC Glucose uptake protein DN405_23180 ENOG4108ZAF Molybdopterin DN405_23185 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DN405_23190 ENOG4105CVM Molybdenum cofactor synthesis domain protein DN405_23200 ENOG4105D06 uba thif-type nad fad binding protein DN405_23205 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DN405_23230 ENOG41085GJ domain protein DN405_23240 ENOG4105DWV Homoserine O-trans-acetylase DN405_23250 ENOG4108B31 Spore germination protein DN405_23275 ENOG4105C8T Leucyl-tRNA synthetase DN405_23280 ENOG410605W Major Facilitator DN405_23285 ENOG4107S91 Sodium hydrogen exchanger DN405_23290 ENOG4105NCW Trka-c domain protein DN405_23305 ENOG4105C19 ABC transporter DN405_23325 ENOG4105N5T Radical SAM Protein DN405_23355 ENOG4105E8V Alpha Beta Hydrolase Fold protein DN405_23360 ENOG4108Z0R Transferase DN405_23365 ENOG4105YVM Phosphoesterase, PA-phosphatase related DN405_23370 ENOG4105BZF Glycosyl transferase (Group 1 DN405_23380 ENOG4105EPU Molybdenum cofactor synthesis domain protein DN405_23390 ENOG4108MK9 spermidine N(1)-acetyltransferase DN405_23465 ENOG4105BZU Histidine kinase DN405_23470 ENOG4105BZU Histidine kinase DN405_23475 ENOG4105CH6 catalase DN405_23485 ENOG4107S9D Alpha beta hydrolase DN405_23490 ENOG4107T7U Sulfatase DN405_23505 ENOG4105D2X ABC transporter substrate-binding protein DN405_23515 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DN405_23585 ENOG4108V2W Carbonate dehydratase DN405_23590 ENOG4105C4M (Ubiquinol oxidase) subunit I DN405_23595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DN405_23635 ENOG41087YS Phage shock protein A DN405_23665 ENOG4105BZU Histidine kinase DN405_23670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_23695 ENOG4108UGV hypoxanthine phosphoribosyltransferase DN405_23700 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DN405_23765 ENOG4107ZTW SNARE associated Golgi DN405_23780 ENOG4105C19 ABC transporter DN405_23785 ENOG41086D8 Transcriptional regulator DN405_23800 ENOG41082BM Transcriptional regulator, arsr family DN405_23850 ENOG4105C6Z Gluconate DN405_23855 ENOG4105FDP GntR family transcriptional regulator DN405_23875 ENOG41069H0 dihydroorotase EC 3.5.2.3 DN405_23895 ENOG4105DTQ mandelate racemase muconate lactonizing DN405_23900 ENOG4105CEY Amp-dependent synthetase and ligase DN405_23905 ENOG4108IPT Naphthoate synthase DN405_23910 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DN405_23915 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DN405_23920 ENOG4105E4F Isochorismate synthase DN405_23925 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DN405_23935 ENOG4105VEQ Cold shock protein DN405_23965 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DN405_23980 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DN405_23990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN405_23995 ENOG4108Q5F Tetr family transcriptional regulator DN405_24095 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DN405_24130 ENOG4105KT7 mgtC SapB transporter DN405_24135 ENOG4107PBV potassium channel DN405_24155 ENOG4105WG9 Conserved Protein DN405_24165 ENOG4105CHM Aminotransferase DN405_24170 ENOG4108ZB6 transcriptional regulator AsnC family DN405_24175 ENOG4105C5I Dehydrogenase DN405_24180 ENOG4108MUZ hydrolase DN405_24190 ENOG4105C87 Aminotransferase class I and II DN405_24200 ENOG4105Y38 Kinase-associated protein B DN405_24210 ENOG4107R3E Citrate transporter DN405_24225 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DN405_24230 ENOG4105KA0 thioesterase Superfamily protein DN405_24245 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN405_24270 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) DN405_24275 ENOG4106YN8 Prenyltransferase DN405_24285 ENOG41069ER domain protein DN405_24300 ENOG4105CEP NADH dehydrogenase DN405_24330 ENOG4105EWC Purine nucleoside phosphorylase DN405_24350 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DN405_24375 ENOG4108JJA ABC, transporter DN405_24380 ENOG4105C4B ABC transporter, permease DN405_24385 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DN405_24440 ENOG41083MR nifu domain-containing protein DN405_24455 ENOG4108W5N phosphatidylglycerophosphatase a DN405_24475 ENOG4105DAX Pfam:DUF2983 DN405_24490 ENOG4105DYS nad(p)h dehydrogenase (quinone) DN405_24495 ENOG4105D4U had-superfamily hydrolase, subfamily iia DN405_24510 ENOG4105CBT Fructose-1,6-bisphosphatase DN405_24535 ENOG4105MMD transcriptional regulator DN405_24540 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DN405_24545 ENOG4107TXC Transcriptional regulator DN405_24550 ENOG41090T1 Membrane DN405_24575 ENOG4105FAA peptidase M23 DN405_24580 ENOG4108YTE sporulation protein YunB DN405_24585 ENOG4105KZD Domain of unknown function (DUF1805) DN405_24590 ENOG4107R8B 5'-nucleotidase DN405_24600 ENOG4105DIW FeS assembly protein SUFB DN405_24605 ENOG4108UNV SUF system FeS assembly protein, NifU family DN405_24610 ENOG4105C9B Cysteine desulfurase DN405_24615 ENOG4105JRK feS assembly protein SufD DN405_24620 ENOG4105C3K feS assembly ATPase SufC DN405_24625 ENOG4105D01 (LipO)protein DN405_24630 ENOG4105D01 (LipO)protein DN405_24635 ENOG4108UMI ABC transporter, permease DN405_24665 ENOG41080E8 Transcriptional regulator, Spx MgsR family DN405_24685 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DN405_24710 ENOG4108W8B Beta-lactamase domain protein DN405_24715 ENOG4105C1G acyl-Coa dehydrogenase DN405_24720 ENOG4105CHU acetyl-coa acetyltransferase DN405_24735 ENOG4105DZ1 carboxypeptidase DN405_24755 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DN405_24765 ENOG4108SUT Major Facilitator Superfamily DN405_24770 ENOG4107R7I amino acid DN405_24785 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN405_24795 ENOG4107AYK membrAne DN405_24835 ENOG4107ZTW SNARE associated Golgi DN405_24845 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DN405_24850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_24855 ENOG4105BZU Histidine kinase DN405_24870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DN405_24885 ENOG4105C8Q Methyl-accepting chemotaxis DN405_24890 ENOG4105VG1 fes assembly suf system protein DN405_24895 ENOG4105D4Y metalloprotease DN405_24900 ENOG4105C2I pirin domain protein DN405_24915 ENOG4107T5V SNARE associated Golgi DN405_24920 ENOG4107S91 Sodium hydrogen exchanger DN405_24925 ENOG4105NCW Trka-c domain protein DN405_24935 ENOG4108RMU ferritin dps family protein DN405_24960 ENOG4108URH decarboxylase DN405_24970 ENOG41090A1 ferritin DN405_24980 ENOG4105D9N nucleoside DN405_24985 ENOG4105D9N nucleoside DN405_25000 ENOG4108RYK Nad-dependent epimerase dehydratase DN405_25015 ENOG4105CV8 reductase DN405_25020 ENOG4105F27 Major Facilitator DN405_25025 ENOG4105KVH Transcriptional regulator DN405_25040 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DN405_25045 ENOG4105D4A Cell wall formation (By similarity) DN405_25055 ENOG4105C8Q Methyl-accepting chemotaxis DN405_25065 ENOG4105WMR Protein CrcB homolog DN405_25070 ENOG4105WMR Protein CrcB homolog DN405_25085 ENOG4108MK9 spermidine N(1)-acetyltransferase DN405_25090 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DN405_25120 ENOG4108IPW abc transporter atp-binding protein DN405_25125 ENOG4105CM4 permease protein DN405_25175 ENOG4105EWM Histidine kinase DN405_25180 ENOG4105CJZ response regulator DN405_25185 ENOG4105C19 ABC transporter DN405_25205 ENOG4105C19 ABC transporter DN405_25240 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DN405_25250 ENOG4105XZU Preprotein translocase, subunit SecG DN405_25255 ENOG41067MG lrgb family DN405_25305 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN405_25325 ENOG41090VF Stage v sporulation protein ac DN405_25330 ENOG4105CZ3 stage V sporulation protein ad DN405_25345 ENOG4108QY0 Membrane DN405_25350 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DN405_25355 ENOG4105KRI phosphocarrier protein (HPr DN405_25365 ENOG4105CHW UPF0052 protein DN405_25370 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DN405_25375 ENOG4108Z4K mutator MutT protein DN405_25385 ENOG4105C3M thioredoxin reductase DN405_25395 ENOG4108S4C acetyltransferase DN405_25415 ENOG41086DT Membrane protein of unknown function DN405_25425 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DN405_25430 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DN405_25445 ENOG4107TXC Transcriptional regulator DN405_25460 ENOG4105HMI Membrane DN405_25465 ENOG4105DUM transcriptional regulator, lysR family DN405_25475 ENOG4108WS4 fmn reductase DN405_25490 ENOG4105BZ1 (ABC) transporter DN405_25500 ENOG4105CN1 protease DN405_25505 ENOG4105CRP Part of the ABC transporter FtsEX involved in DN405_25510 ENOG4105CAK Cell division ATP-binding protein ftsE DN405_25535 ENOG4105MS2 ribosomal subunit Interface protein DN405_25540 ENOG4105VEQ Cold shock protein DN405_25545 ENOG41081UC Inherit from COG: Competence protein DN405_25560 ENOG4105KVH Transcriptional regulator DN405_25570 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DN405_25575 ENOG4108KGH TRANSCRIPTIONal DN405_25580 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DN405_25585 ENOG4105C6Y Udp-glucose 6-dehydrogenase DN405_25590 ENOG4105ESV Glycosyl transferase, family 4 DN405_25600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DN405_25620 ENOG4105F8D glycoside hydrolase family 4 DN405_25625 ENOG4105VCP PTS System DN405_25630 ENOG4105CK1 PTS System DN405_25640 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DN405_25645 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DN405_25650 ENOG4105VCP PTS System DN405_25660 ENOG4105VZJ PTS System DN405_25680 ENOG4105ECB domain protein DN405_25685 ENOG4107RSM transcriptional regulator DN405_25735 ENOG4105DAA L-lactate DN405_25745 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DN405_25760 ENOG4105E0M Sulfatase DN405_25785 ENOG4107R8N Glycosyl transferase, family 2 DN405_25790 ENOG4105C94 Transporter DN405_25800 ENOG41069ER domain protein DN405_25830 ENOG4105KBK Zinc finger, swim domain protein DN405_25835 ENOG4105C0D helicase DN405_25865 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DN405_25875 ENOG4107RBB ABC transporter, permease DN405_25880 ENOG4105C19 ABC transporter DN405_25900 ENOG4105CXY transporter DN405_25915 ENOG4105BZU Histidine kinase DN405_25920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_25930 ENOG4108KGH TRANSCRIPTIONal DN405_25940 ENOG4105C6Y Udp-glucose 6-dehydrogenase DN405_25945 ENOG4108SHN Glycosyl transferase, family 2 DN405_25965 ENOG4105E2K Glycosyl transferase (Group 1 DN405_25970 ENOG4107SBE Glycosyl transferase (Group 1 DN405_25975 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DN405_25985 ENOG4105C5E polysaccharide biosynthesis protein DN405_25995 ENOG4105D7W serine acetyltransferase DN405_26000 ENOG4105D3Q Sugar transferase DN405_26005 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DN405_26015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DN405_26020 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DN405_26025 ENOG4107YJ4 chain length determinant protein DN405_26030 ENOG4105HTX biosynthesis protein DN405_26035 ENOG4108QV3 biosynthesis protein DN405_26050 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DN405_26060 ENOG4105FRN stage II sporulation protein DN405_26075 ENOG4105DY9 regulatoR DN405_26095 ENOG4106778 Protein of unknown function (DUF1146) DN405_26100 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN405_26105 ENOG4105C8S subunit m DN405_26110 ENOG4105D65 subunit l DN405_26135 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DN405_26140 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN405_26150 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DN405_26155 ENOG4105BZU Histidine kinase DN405_26205 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DN405_26210 ENOG41062M3 atp synthase DN405_26230 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DN405_26235 ENOG4108UIC UPF0340 protein DN405_26240 ENOG4108YZG isomerase DN405_26255 ENOG4108VGI doxx family DN405_26260 ENOG4107XC4 flavin reductase domain protein, FMN-binding DN405_26275 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DN405_26285 ENOG4108ZXQ stage ii sporulation protein r DN405_26290 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DN405_26295 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DN405_26300 ENOG4107104 thymidine kinase DN405_26315 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DN405_26320 ENOG4105CBT Fructose-1,6-bisphosphatase DN405_26325 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DN405_26345 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DN405_26360 ENOG4105C1G acyl-Coa dehydrogenase DN405_26365 ENOG4105C1G acyl-Coa dehydrogenase DN405_26370 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DN405_26380 ENOG4105DF6 Fe-S oxidoreductase DN405_26395 ENOG4105BZU Histidine kinase DN405_26410 ENOG4105D4Y metalloprotease DN405_26420 ENOG4105BZU Histidine kinase DN405_26425 ENOG4105KCT ABC transporter DN405_26430 ENOG4108M15 ABC transporter DN405_26435 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DN405_26445 ENOG4105IIU Aminopeptidase DN405_26470 ENOG410684U Domain of unknown function (DUF1934) DN405_26490 ENOG4105CYW agmatinase DN405_26500 ENOG4105DXB Major Facilitator superfamily DN405_26505 ENOG4107SWG transcriptional regulator MERR family DN405_26510 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DN405_26515 ENOG4105BZ4 penicillin-binding protein DN405_26520 ENOG4108XFG YwhD family DN405_26525 ENOG4108Z4T Peptidase M50 DN405_26530 ENOG41069HH 4-oxalocrotonate tautomerase DN405_26535 ENOG4105DCI Phosphohydrolase DN405_26540 ENOG4108MES Periplasmic binding protein DN405_26545 ENOG4105E0A ABC, transporter DN405_26550 ENOG4105EHG Permease protein DN405_26555 ENOG4105DQ5 transport system permease protein DN405_26565 ENOG4108VCI transcription factor, rsfa family DN405_26570 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DN405_26575 ENOG4108IJ2 phosphate acetyltransferase DN405_26580 ENOG4107UEZ chlorite dismutase DN405_26590 ENOG4108VKI Cell wall hydrolase DN405_26610 ENOG4107SVH Potassium channel protein DN405_26620 ENOG410667J hydrolase DN405_26625 ENOG4105VCH membrane DN405_26635 ENOG4108TU7 Inherit from COG: (ABC) transporter DN405_26640 ENOG4105CJ1 ABC, transporter DN405_26645 ENOG41090WU lipolytic protein G-D-S-L family DN405_26660 ENOG4105D6E homoserine dehydrogenase DN405_26685 ENOG4108Y4K DNA-binding transcriptional activator DN405_26695 ENOG4105WH1 Two component transcriptional regulator luxr family DN405_26700 ENOG4105BZU Histidine kinase DN405_26705 ENOG4105DWF phosphomethylpyrimidine kinase DN405_26710 ENOG4105BZU Histidine kinase DN405_26715 ENOG4105VCD cytoplasmic protein DN405_26720 ENOG4105D22 carbon starvation protein DN405_26725 ENOG4105DY9 regulatoR DN405_26730 ENOG41079KZ Major Facilitator Superfamily DN405_26745 ENOG4105CG5 Glycosyl transferase (Group 1 DN405_26755 ENOG4105EN6 Membrane DN405_26760 ENOG4106YBV Methyl-accepting chemotaxis DN405_26770 ENOG4108S4H thioesterase Superfamily protein DN405_26780 ENOG4105K64 Glycosyl transferase, family 2 DN405_26795 ENOG4105CKK Glycosyl transferase, family 2 DN405_26800 ENOG4105C5H ABC transporter DN405_26805 ENOG41067SE Tetr family transcriptional regulator DN405_26815 ENOG4105E0X reductase DN405_26820 ENOG4106F5Q Membrane DN405_26835 ENOG4108NEV two component transcriptional regulator, LytTR family DN405_26840 ENOG4108HRK Histidine kinase DN405_26845 ENOG4107RGD Major Facilitator superfamily DN405_26865 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DN405_26875 ENOG4105IW1 AmiS UreI transporter DN405_26885 ENOG4105CMR udp-glucose 4-epimerase DN405_26890 ENOG4108UT2 hemolysin iii DN405_26900 ENOG4105C1J atp-dependent rna helicase DN405_26905 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DN405_26910 ENOG4105DPN Oligoendopeptidase f DN405_26920 ENOG4105BZU Histidine kinase DN405_26925 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DN405_26935 ENOG4105C0H protease DN405_26940 ENOG4105Q2H domain protein DN405_26955 ENOG4105BZU Histidine kinase DN405_26960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DN405_26985 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DN405_26990 ENOG4105CDU Replicative dna helicase DN405_27000 ENOG4105BZR domain protein DN405_27005 ENOG4108XMW Membrane DN405_27015 ENOG4108UUM single-stranded DNA-binding protein DN405_27025 ENOG4105C3G gtp-binding protein DN405_27030 ENOG4105VDK protein, conserved in bacteria DN405_27035 ENOG4105D8X mechanosensitive ion channel DN405_27040 ENOG4108ZDA Sporulation protein YyaC DN405_27045 ENOG4105FA0 parb-like partition protein DN405_27050 ENOG4107QJE Chromosome Partitioning Protein DN405_27065 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DN405_27070 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DN405_27080 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DN405_27125 ENOG4107JM4 Tetratricopeptide repeat DN405_27310 ENOG4105K4H Nlp p60 protein DN405_27380 ENOG4105C9U ATP-dependent DNA helicase RecQ DN405_27410 ENOG4107QI6 Cysteine desulfurase DN405_27465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DN405_27520 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DN405_27535 ENOG4108J59 Extracellular solute-binding protein, family 5 DN405_27565 ENOG4105K4H Nlp p60 protein DN405_27580 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DN405_27740 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DN405_27865 ENOG4105K4H Nlp p60 protein DN405_27895 ENOG4105C9U ATP-dependent DNA helicase RecQ DN405_27905 ENOG4105BZU Histidine kinase DN405_27935 ENOG4107QJE Chromosome Partitioning Protein