locus-tag	class	description
DI291_00010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DI291_00015	COG1263	PTS System
DI291_00015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_00020	COG0359	binds to the 23S rRNA
DI291_00025	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DI291_00030	COG4241	membrane
DI291_00035	COG5577	PFAM Coat F domain
DI291_00040	COG0589	response to stress
DI291_00045	COG0659	secondary active sulfate transmembrane transporter activity
DI291_00050	COG2271	Major facilitator Superfamily
DI291_00055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DI291_00060	COG0629	single-stranded DNA binding
DI291_00065	COG0360	Binds together with S18 to 16S ribosomal RNA
DI291_00070	COG0012	GTP binding
DI291_00080	COG4481	Protein conserved in bacteria
DI291_00085	COG3949	Membrane
DI291_00095	COG1475	DNA binding
DI291_00100	COG1192	Involved in chromosome partitioning
DI291_00105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DI291_00110	COG1595	DNA-templated transcription, initiation
DI291_00115	COG1475	DNA binding
DI291_00120	COG0357	Ribosomal RNA small subunit methyltransferase G
DI291_00125	COG0445	tRNA wobble uridine modification
DI291_00130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DI291_00135	COG1847	R3H domain protein
DI291_00140	COG0706	membrane insertase activity
DI291_00145	COG0594	ribonuclease P activity
DI291_00155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DI291_00160	COG0592	DNA-directed DNA polymerase activity
DI291_00165	COG2501	S4 domain
DI291_00170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DI291_00180	COG0187	DNA topoisomerase II activity
DI291_00185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DI291_00220	COG0516	GMP reductase activity
DI291_00220	COG0517	IMP dehydrogenase activity
DI291_00225	COG1686	Belongs to the peptidase S11 family
DI291_00230	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DI291_00235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DI291_00240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DI291_00245	COG1929	Belongs to the glycerate kinase type-1 family
DI291_00250	COG2610	gluconate transmembrane transporter activity
DI291_00255	COG3835	regulator
DI291_00270	COG1428	Deoxynucleoside kinase
DI291_00275	COG1428	Deoxynucleoside kinase
DI291_00280	COG1388	LysM domain
DI291_00280	COG3858	chitin binding
DI291_00285	COG1335	isochorismatase
DI291_00290	COG0590	tRNA wobble adenosine to inosine editing
DI291_0030	COG1113	amino acid transport
DI291_00300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DI291_00305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DI291_00310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DI291_00355	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DI291_00360	COG3853	Toxic anion resistance protein (TelA)
DI291_00365	COG1982	Orn Lys Arg decarboxylase major
DI291_00370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DI291_00375	COG3870	Protein conserved in bacteria
DI291_00380	COG1728	Protein conserved in bacteria
DI291_00385	COG0470	DNA polymerase III
DI291_00390	COG1774	PSP1 C-terminal conserved region
DI291_00395	COG4467	Involved in initiation control of chromosome replication
DI291_0040	COG2851	Citrate transporter
DI291_00400	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DI291_00405	COG2827	Endonuclease containing a URI domain
DI291_00410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DI291_00415	COG2002	toxin-antitoxin pair type II binding
DI291_00420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_00420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_00425	COG0084	hydrolase, TatD family'
DI291_00430	COG3584	3D domain protein
DI291_00430	COG3583	domain protein
DI291_00435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DI291_00440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DI291_0045	COG3181	Tripartite tricarboxylate transporter family receptor
DI291_00450	COG4466	Protein conserved in bacteria
DI291_00460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DI291_00465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DI291_00470	COG0251	oxidation-reduction process
DI291_00475	COG2088	sporulation resulting in formation of a cellular spore
DI291_00480	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DI291_00485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DI291_00490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DI291_00495	COG0193	aminoacyl-tRNA hydrolase activity
DI291_0050	COG4565	transcriptional regulatory protein
DI291_00505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DI291_00510	COG2002	toxin-antitoxin pair type II binding
DI291_00515	COG2244	polysaccharide biosynthetic process
DI291_00520	COG3956	TIGRFAM MazG family protein
DI291_00525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DI291_00540	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DI291_00545	COG1098	S1 RNA binding domain
DI291_0055	COG3290	protein histidine kinase activity
DI291_00560	COG2208	phosphoserine phosphatase activity
DI291_00565	COG2304	oxidoreductase activity
DI291_00570	COG0515	serine threonine protein kinase
DI291_00575	COG0037	tRNA processing
DI291_00580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DI291_00585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DI291_00590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DI291_00595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DI291_00600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DI291_00605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_00615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI291_00620	COG0512	Glutamine amidotransferase of anthranilate synthase
DI291_00625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DI291_00630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DI291_00635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DI291_00640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DI291_00645	COG1396	sequence-specific DNA binding
DI291_00650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DI291_00655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DI291_00735	COG4463	regulation of RNA biosynthetic process
DI291_00740	COG3880	PFAM UvrB UvrC protein
DI291_00745	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DI291_0075	COG0697	spore germination
DI291_00750	COG0542	response to heat
DI291_00755	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DI291_00760	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DI291_00765	COG4956	integral membrane protein (PIN domain superfamily)
DI291_00770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DI291_00775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DI291_00780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DI291_00785	COG1045	serine acetyltransferase
DI291_00790	COG0215	cysteine-tRNA ligase activity
DI291_00795	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DI291_00800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI291_00805	COG3688	RNA-binding protein containing a PIN domain
DI291_00825	COG0250	Participates in transcription elongation, termination and antitermination
DI291_00830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DI291_00835	COG0081	regulation of translation
DI291_00840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DI291_00845	COG0222	ribosome binding
DI291_00850	COG2813	Specifically methylates the guanine in position
DI291_00855	COG0085	RNA polymerase activity
DI291_00860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DI291_00865	COG1358	cellular component organization or biogenesis
DI291_00870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DI291_00875	COG0049	tRNA binding
DI291_00880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DI291_00885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DI291_00895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DI291_00900	COG0088	Forms part of the polypeptide exit tunnel
DI291_00905	COG0089	rRNA binding
DI291_00915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DI291_00920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DI291_00925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DI291_00930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DI291_00935	COG0255	Belongs to the universal ribosomal protein uL29 family
DI291_00940	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DI291_00945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DI291_00950	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DI291_00955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DI291_00960	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DI291_00965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DI291_00970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DI291_00975	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DI291_00980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DI291_00985	COG1841	ribosomal large subunit assembly
DI291_00990	COG0200	Binds to the 23S rRNA
DI291_00995	COG0201	protein transport
DI291_01000	COG0563	adenylate kinase activity
DI291_01005	COG0024	Methionine aminopeptidase
DI291_01010	COG2163	COG2163 Ribosomal protein L14E L6E L27E
DI291_01015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DI291_01020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DI291_01025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DI291_01030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DI291_01035	COG0202	RNA polymerase activity
DI291_01040	COG0203	ribosomal protein L17
DI291_01045	COG1122	ATPase activity
DI291_0105	COG0596	Alpha beta hydrolase
DI291_01050	COG1122	ATPase activity
DI291_01055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DI291_01060	COG0101	tRNA pseudouridine synthase activity
DI291_01065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DI291_01070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DI291_01075	COG2318	DinB family
DI291_01090	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_01095	COG0489	protein tyrosine kinase activity
DI291_01105	COG2194	sulfuric ester hydrolase activity
DI291_01110	COG0726	polysaccharide deacetylase
DI291_01140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_01150	COG0385	Bile acid
DI291_01165	COG3876	Protein conserved in bacteria
DI291_01170	COG1472	Belongs to the glycosyl hydrolase 3 family
DI291_01175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_01180	COG1263	PTS System
DI291_01185	COG1737	Transcriptional regulator
DI291_01190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DI291_01195	COG1683	Conserved Protein
DI291_0120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DI291_01230	COG1595	DNA-templated transcription, initiation
DI291_01235	COG5662	AntiSigma factor
DI291_01240	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DI291_01245	COG4856	YbbR-like protein
DI291_01250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DI291_01255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DI291_01275	COG1725	Transcriptional regulator
DI291_01285	COG0789	Transcriptional regulator
DI291_01295	COG0640	Transcriptional regulator
DI291_01300	COG2814	Major facilitator Superfamily
DI291_01320	COG1131	(ABC) transporter
DI291_01345	COG1132	(ABC) transporter
DI291_01350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DI291_01360	COG1132	(ABC) transporter
DI291_01365	COG2312	Erythromycin esterase
DI291_01385	COG1011	Hydrolase
DI291_01405	COG2211	Major facilitator Superfamily
DI291_01425	COG1331	Highly conserved protein containing a thioredoxin domain
DI291_01430	COG1331	Highly conserved protein containing a thioredoxin domain
DI291_0145	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DI291_0155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DI291_01565	COG1331	Highly conserved protein containing a thioredoxin domain
DI291_01575	COG2226	methyltransferase
DI291_01580	COG0076	glutamate decarboxylase activity
DI291_01585	COG0778	Nitroreductase
DI291_01590	COG1802	Transcriptional regulator
DI291_01595	COG0730	response to heat
DI291_01615	COG1283	sodium-dependent phosphate transmembrane transporter activity
DI291_01620	COG4682	membrane
DI291_0165	COG1136	(ABC) transporter
DI291_01650	COG0697	spore germination
DI291_01655	COG2207	Transcriptional regulator
DI291_01655	COG1917	Cupin 2, conserved barrel domain protein
DI291_01665	COG2197	response regulator
DI291_01680	COG0371	Dehydrogenase
DI291_01695	COG4257	antibiotic catabolic process
DI291_01705	COG0833	amino acid
DI291_01710	COG2040	homocysteine
DI291_01720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_01720	COG1263	PTS System
DI291_01730	COG2323	membrane
DI291_01735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DI291_01735	COG4451	ribulose bisphosphate carboxylase, small
DI291_01745	COG2205	protein histidine kinase activity
DI291_0175	COG1609	Transcriptional regulator
DI291_01750	COG1115	amino acid carrier protein
DI291_01755	COG2066	Belongs to the glutaminase family
DI291_01760	COG4191	Histidine kinase
DI291_01765	COG0784	Response regulator, receiver
DI291_01790	COG3540	Alkaline phosphatase
DI291_01795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DI291_0180	COG1653	transport
DI291_01800	COG0805	protein transport
DI291_01805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DI291_01810	COG1012	belongs to the aldehyde dehydrogenase family
DI291_01815	COG2271	Major facilitator Superfamily
DI291_01820	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_01825	COG2186	Transcriptional regulator
DI291_01830	COG2721	sulfolactate sulfo-lyase activity
DI291_0185	COG1175	transmembrane transport
DI291_01850	COG0745	RESPONSE REGULATOR receiver
DI291_01855	COG2205	protein histidine kinase activity
DI291_01860	COG1131	(ABC) transporter
DI291_01885	COG3173	Aminoglycoside phosphotransferase
DI291_01890	COG1846	Transcriptional regulator
DI291_01895	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_0190	COG0395	ABC-type sugar transport system, permease component
DI291_01915	COG0789	Transcriptional regulator
DI291_01940	COG0697	spore germination
DI291_01945	COG1714	RDD family
DI291_0195	COG1486	melibiose metabolic process
DI291_01950	COG1405	negative regulation of cell septum assembly
DI291_01950	COG3012	SEC-C Motif Domain Protein
DI291_01955	COG1131	(ABC) transporter
DI291_01980	COG0583	DNA-binding transcription factor activity
DI291_01985	COG1942	4-Oxalocrotonate Tautomerase
DI291_01990	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_02005	COG1288	antiporter activity
DI291_02015	COG0252	asparaginase activity
DI291_02020	COG0456	acetyltransferase
DI291_02030	COG1164	Oligoendopeptidase f
DI291_02035	COG2261	transglycosylase associated protein
DI291_02045	COG0247	lactate metabolic process
DI291_02050	COG0277	FAD linked oxidase domain protein
DI291_02055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_02060	COG1447	Phosphotransferase system cellobiose-specific component IIA
DI291_02065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_02070	COG1486	melibiose metabolic process
DI291_02075	COG2188	Transcriptional regulator
DI291_02080	COG3394	polysaccharide catabolic process
DI291_02095	COG3591	Belongs to the peptidase S1B family
DI291_02100	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_02110	COG1595	DNA-templated transcription, initiation
DI291_02120	COG3773	Cell wall hydrolase
DI291_02125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_02130	COG3883	PFAM NLP P60 protein
DI291_02130	COG0791	NLP P60 protein
DI291_02140	COG1131	(ABC) transporter
DI291_02145	COG1309	transcriptional regulator
DI291_02165	COG2310	stress, protein
DI291_02170	COG2310	stress, protein
DI291_02175	COG2310	stress, protein
DI291_02180	COG0861	Integral membrane protein TerC family
DI291_02200	COG3853	Toxic anion resistance protein (TelA)
DI291_02205	COG0785	Cytochrome C biogenesis protein
DI291_02215	COG2223	nitrite transmembrane transporter activity
DI291_02220	COG0039	L-malate dehydrogenase activity
DI291_02225	COG1620	l-lactate permease
DI291_02230	COG1280	lysine exporter protein (LysE YggA)
DI291_02235	COG1113	amino acid transport
DI291_02240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DI291_02245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DI291_02250	COG3541	Predicted nucleotidyltransferase
DI291_02260	COG0506	proline dehydrogenase activity
DI291_02265	COG1012	belongs to the aldehyde dehydrogenase family
DI291_02270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_02275	COG2508	Transcriptional regulator
DI291_02280	COG3689	TIGRFAM TIGR03943 family protein
DI291_02285	COG0701	Predicted permease
DI291_02290	COG3458	cephalosporin-C deacetylase activity
DI291_02315	COG0765	amino acid transport
DI291_02320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DI291_02325	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_02330	COG1116	anion transmembrane transporter activity
DI291_02335	COG2723	6-phospho-beta-galactosidase activity
DI291_02345	COG3209	COG3209 Rhs family protein
DI291_02355	COG5444	nuclease activity
DI291_02385	COG1177	transmembrane transport
DI291_02390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_02395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_02400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_02405	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DI291_02410	COG0697	spore germination
DI291_02415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_02425	COG2819	hydrolase of the alpha beta superfamily
DI291_02430	COG2207	Transcriptional regulator
DI291_02430	COG3708	Transcriptional regulator
DI291_02435	COG2364	Membrane
DI291_02465	COG1126	abc transporter atp-binding protein
DI291_02470	COG0765	amino acid transport
DI291_02475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DI291_02480	COG3829	transcription factor binding
DI291_02485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DI291_02490	COG0833	amino acid
DI291_02495	COG0010	Belongs to the arginase family
DI291_02500	COG0583	DNA-binding transcription factor activity
DI291_02505	COG0163	prenyltransferase activity
DI291_02510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DI291_02560	COG5444	nuclease activity
DI291_02580	COG2972	Histidine kinase
DI291_02585	COG4753	response regulator
DI291_02585	COG2207	Transcriptional regulator
DI291_02590	COG4213	ABC transporter substrate-binding protein
DI291_02600	COG4214	carbohydrate transport
DI291_02605	COG2271	Major facilitator Superfamily
DI291_02610	COG1846	Transcriptional regulator
DI291_02610	COG0456	acetyltransferase
DI291_02615	COG1874	Beta-galactosidase
DI291_02620	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
DI291_02630	COG3104	oligopeptide transport
DI291_02635	COG5434	Belongs to the glycosyl hydrolase 28 family
DI291_02645	COG0697	spore germination
DI291_02655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DI291_02660	COG0789	Transcriptional regulator
DI291_02665	COG1136	(ABC) transporter
DI291_02670	COG0577	efflux transmembrane transporter activity
DI291_02675	COG0745	RESPONSE REGULATOR receiver
DI291_02680	COG3850	Histidine kinase
DI291_02680	COG5002	protein histidine kinase activity
DI291_02685	COG0840	transmembrane signaling receptor activity
DI291_02690	COG0527	aspartate kinase activity
DI291_02695	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_0270	COG5444	nuclease activity
DI291_02700	COG4605	iron ion homeostasis
DI291_02705	COG4604	ABC transporter, ATP-binding protein
DI291_02710	COG4607	ABC-type enterochelin transport system periplasmic component
DI291_02715	COG2814	Major facilitator Superfamily
DI291_02720	COG1309	transcriptional regulator
DI291_02730	COG0778	Nitroreductase
DI291_02735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DI291_02740	COG0640	Transcriptional regulator
DI291_02745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_02750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DI291_02755	COG0531	amino acid
DI291_02760	COG1012	belongs to the aldehyde dehydrogenase family
DI291_02765	COG0697	spore germination
DI291_02775	COG4549	nuclear export factor GLE1
DI291_02780	COG2372	response to copper ion
DI291_02780	COG1276	copper resistance
DI291_02785	COG1349	DNA-binding transcription factor activity
DI291_02790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DI291_02795	COG0243	molybdopterin cofactor binding
DI291_02800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DI291_02805	COG2146	nitrite reductase [NAD(P)H] activity
DI291_02810	COG1587	Uroporphyrinogen-III synthase
DI291_02810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DI291_02815	COG1802	Transcriptional regulator
DI291_02820	COG0471	metal ion transport
DI291_02825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DI291_02835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_02850	COG3959	Transketolase, thiamine diphosphate binding domain
DI291_02855	COG3958	Transketolase
DI291_02860	COG0561	phosphatase activity
DI291_02865	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DI291_02870	COG1914	H( )-stimulated, divalent metal cation uptake system
DI291_02875	COG4336	lyase activity
DI291_02880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DI291_02885	COG1984	allophanate hydrolase subunit 2
DI291_02890	COG1414	Transcriptional regulator
DI291_02895	COG2755	lipolytic protein G-D-S-L family
DI291_02900	COG2213	PTS system mannitol-specific
DI291_02905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_02910	COG0246	Mannitol dehydrogenase
DI291_02915	COG3711	transcriptional antiterminator
DI291_02920	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_02925	COG1917	Cupin 2, conserved barrel domain protein
DI291_02935	COG3871	stress protein (general stress protein 26)
DI291_0295	COG2814	Major facilitator Superfamily
DI291_02950	COG2814	Major facilitator Superfamily
DI291_02960	COG1522	sequence-specific DNA binding
DI291_02965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DI291_02965	COG0551	DNA topoisomerase type I activity
DI291_02970	COG0287	Prephenate dehydrogenase
DI291_02975	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI291_02975	COG0512	Glutamine amidotransferase of anthranilate synthase
DI291_02980	COG1605	Chorismate mutase
DI291_02985	COG0028	Belongs to the TPP enzyme family
DI291_02990	COG3397	chitin binding
DI291_0300	COG0457	Tetratricopeptide repeat
DI291_03000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_03005	COG1914	H( )-stimulated, divalent metal cation uptake system
DI291_03010	COG2261	transglycosylase associated protein
DI291_03015	COG1027	Aspartate ammonia-lyase
DI291_03020	COG1819	glycosyl
DI291_03025	COG4876	unkown
DI291_03030	COG2217	Heavy metal translocating P-type atpase
DI291_03040	COG0662	Cupin 2, conserved barrel domain protein
DI291_03050	COG0628	permease
DI291_03055	COG1301	dicarboxylic acid transport
DI291_03060	COG1131	(ABC) transporter
DI291_03065	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DI291_03075	COG1960	acyl-CoA dehydrogenase activity
DI291_03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_03095	COG1181	Belongs to the D-alanine--D-alanine ligase family
DI291_03100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DI291_03110	COG0513	Belongs to the DEAD box helicase family
DI291_03115	COG3402	PFAM membrane-flanked domain
DI291_03120	COG3428	Bacterial PH domain
DI291_03125	COG0705	Rhomboid family
DI291_03130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DI291_03135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DI291_03140	COG0864	Transcriptional regulator
DI291_03145	COG2337	Toxic component of a toxin-antitoxin (TA) module
DI291_03150	COG1366	Belongs to the anti-sigma-factor antagonist family
DI291_03155	COG1366	Belongs to the anti-sigma-factor antagonist family
DI291_03160	COG2172	sigma factor antagonist activity
DI291_03165	COG2208	phosphoserine phosphatase activity
DI291_03180	COG1191	sigma factor activity
DI291_03185	COG2208	phosphoserine phosphatase activity
DI291_03190	COG2183	response to ionizing radiation
DI291_03195	COG1309	transcriptional regulator
DI291_03205	COG2409	Drug exporters of the RND superfamily
DI291_03205	COG1033	growth of symbiont in host cell
DI291_03215	COG3091	SprT-like family
DI291_03255	COG0582	viral genome integration into host DNA
DI291_03270	COG1793	dna ligase
DI291_03275	COG0726	polysaccharide deacetylase
DI291_03280	COG3239	Fatty acid desaturase
DI291_03285	COG1278	Cold shock
DI291_03310	COG2364	Membrane
DI291_03315	COG1846	Transcriptional regulator
DI291_03320	COG0456	acetyltransferase
DI291_03325	COG2808	Putative FMN-binding domain
DI291_03335	COG1733	regulation of RNA biosynthetic process
DI291_03340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_03370	COG3545	Serine hydrolase
DI291_03375	COG1733	regulation of RNA biosynthetic process
DI291_03385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DI291_03390	COG1113	amino acid transport
DI291_0340	COG5444	nuclease activity
DI291_03420	COG5566	PFAM Mor transcription activator
DI291_03425	COG1595	DNA-templated transcription, initiation
DI291_03435	COG2755	lipolytic protein G-D-S-L family
DI291_03435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DI291_03440	COG0494	nUDIX hydrolase
DI291_03445	COG2814	Major facilitator Superfamily
DI291_0345	COG5444	nuclease activity
DI291_03450	COG1979	alcohol dehydrogenase
DI291_03455	COG0745	RESPONSE REGULATOR receiver
DI291_03455	COG2972	Histidine kinase
DI291_03460	COG3279	Response regulator of the LytR AlgR family
DI291_03470	COG3764	Sortase (surface protein transpeptidase)
DI291_03480	COG2814	Major facilitator Superfamily
DI291_03520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DI291_03525	COG0802	atpase or kinase
DI291_03530	COG1214	PFAM Peptidase M22, glycoprotease
DI291_03535	COG0456	acetyltransferase
DI291_03540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DI291_03545	COG0488	(ABC) transporter
DI291_03550	COG0315	cyclic pyranopterin monophosphate synthase activity
DI291_03555	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DI291_03560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DI291_03565	COG0805	protein transport
DI291_03575	COG1266	CAAX protease self-immunity
DI291_03580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DI291_03585	COG0459	protein refolding
DI291_03595	COG2720	vancomycin resistance protein
DI291_03615	COG2135	peptidase activity
DI291_03625	COG1309	transcriptional regulator
DI291_03630	COG0574	Belongs to the PEP-utilizing enzyme family
DI291_03630	COG3848	Pyruvate phosphate dikinase
DI291_03640	COG3189	MarR family transcriptional regulator
DI291_03645	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DI291_03650	COG2272	Belongs to the type-B carboxylesterase lipase family
DI291_03655	COG2814	Major facilitator Superfamily
DI291_03660	COG1842	Phage shock protein A
DI291_03665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DI291_03670	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DI291_03675	COG4260	virion core protein, lumpy skin disease virus
DI291_03685	COG1378	Sugar-specific transcriptional regulator TrmB
DI291_03690	COG1280	lysine exporter protein (LysE YggA)
DI291_03695	COG3339	Conserved Protein
DI291_03700	COG0772	Belongs to the SEDS family
DI291_03705	COG0772	Belongs to the SEDS family
DI291_03725	COG0726	polysaccharide deacetylase
DI291_03735	COG1609	Transcriptional regulator
DI291_03740	COG0366	Alpha amylase catalytic
DI291_03745	COG2182	Extracellular solute-binding protein
DI291_0375	COG1687	branched-chain amino acid
DI291_03750	COG1175	transmembrane transport
DI291_03755	COG3833	ABC-type maltose transport systems, permease component
DI291_03760	COG5521	maltodextrose utilization protein MalA
DI291_03765	COG1554	hydrolase, family 65, central catalytic
DI291_03770	COG0366	Alpha amylase catalytic
DI291_03775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DI291_03780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DI291_03785	COG1846	Transcriptional regulator
DI291_0380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DI291_03800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DI291_03805	COG0823	Involved in the tonB-independent uptake of proteins
DI291_03835	COG0702	epimerase
DI291_03845	COG2132	Multicopper oxidase
DI291_03865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DI291_03870	COG0714	Associated with various cellular activities
DI291_03875	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DI291_03880	COG1305	Transglutaminase-like
DI291_03885	COG0519	Catalyzes the synthesis of GMP from XMP
DI291_03885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DI291_03895	COG2252	PERMEase
DI291_03910	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DI291_03920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DI291_03925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DI291_03930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DI291_03935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DI291_03940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DI291_03945	COG0047	phosphoribosylformylglycinamidine synthase activity
DI291_0395	COG1309	transcriptional regulator
DI291_03950	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DI291_03955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DI291_03960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DI291_03965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DI291_03970	COG0138	bifunctional purine biosynthesis protein purh
DI291_03975	COG0151	Belongs to the GarS family
DI291_03985	COG2124	cytochrome p450
DI291_0400	COG1609	Transcriptional regulator
DI291_04010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DI291_04015	COG1470	cell adhesion involved in biofilm formation
DI291_04020	COG4496	protein, YerC YecD
DI291_04025	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DI291_04030	COG0210	DNA helicase
DI291_04035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DI291_04040	COG4851	CamS sex pheromone cAM373 precursor
DI291_0405	COG4195	phage-related replication protein
DI291_04090	COG1285	pathogenesis
DI291_04095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_0410	COG1120	ATPase activity
DI291_04100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DI291_04105	COG0154	amidase activity
DI291_04110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DI291_04125	COG4124	Belongs to the glycosyl hydrolase 26 family
DI291_04130	COG1309	transcriptional regulator
DI291_04135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DI291_04145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_04150	COG1957	nucleoside hydrolase
DI291_04155	COG1597	lipid kinase activity
DI291_04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_04190	COG2190	(PTS) system
DI291_04190	COG1263	PTS System
DI291_04195	COG2723	6-phospho-beta-galactosidase activity
DI291_0420	COG0561	phosphatase activity
DI291_04200	COG3711	transcriptional antiterminator
DI291_04205	COG0457	Tetratricopeptide repeat
DI291_04220	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DI291_04220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DI291_04225	COG3586	endonuclease activity
DI291_04230	COG0697	spore germination
DI291_04235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_04240	COG0697	spore germination
DI291_04245	COG0217	transcriptional regulatory protein
DI291_04275	COG1012	belongs to the aldehyde dehydrogenase family
DI291_04280	COG0840	transmembrane signaling receptor activity
DI291_04285	COG0109	protoheme IX farnesyltransferase activity
DI291_04290	COG1309	transcriptional regulator
DI291_04295	COG0471	metal ion transport
DI291_0430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DI291_04300	COG0488	(ABC) transporter
DI291_04320	COG1469	GTP cyclohydrolase I activity
DI291_04335	COG0523	cobalamin synthesis protein
DI291_04340	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
DI291_04345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DI291_0435	COG2186	Transcriptional regulator
DI291_04350	COG0156	8-amino-7-oxononanoate synthase activity
DI291_04355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DI291_04360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DI291_04365	COG2124	cytochrome p450
DI291_04375	COG0789	Transcriptional regulator
DI291_04380	COG2814	Major facilitator Superfamily
DI291_04385	COG0488	(ABC) transporter
DI291_04390	COG0513	Belongs to the DEAD box helicase family
DI291_04395	COG2130	NADP-dependent
DI291_04410	COG0471	metal ion transport
DI291_04425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_04435	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DI291_04440	COG3858	chitin binding
DI291_04445	COG5658	integral membrane protein
DI291_0445	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_04450	COG0640	Transcriptional regulator
DI291_04455	COG1254	Belongs to the acylphosphatase family
DI291_04460	COG2258	MOSC domain
DI291_04470	COG0024	Methionine aminopeptidase
DI291_04475	COG1368	sulfuric ester hydrolase activity
DI291_04485	COG1115	amino acid carrier protein
DI291_04490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_04490	COG1263	PTS System
DI291_04495	COG0366	Alpha amylase catalytic
DI291_0450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DI291_04500	COG2188	Transcriptional regulator
DI291_04525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DI291_04530	COG1045	serine acetyltransferase
DI291_04535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI291_04545	COG1215	transferase activity, transferring glycosyl groups
DI291_0455	COG3959	Transketolase, thiamine diphosphate binding domain
DI291_04550	COG0457	Tetratricopeptide repeat
DI291_04550	COG0463	Glycosyl transferase, family 2
DI291_04560	COG0673	inositol 2-dehydrogenase activity
DI291_04575	COG1733	regulation of RNA biosynthetic process
DI291_04580	COG0778	Nitroreductase
DI291_04585	COG0737	Belongs to the 5'-nucleotidase family
DI291_04590	COG0693	protein deglycase activity
DI291_04595	COG4840	Belongs to the UPF0435 family
DI291_04600	COG1115	amino acid carrier protein
DI291_04605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DI291_04610	COG4980	gas vesicle protein
DI291_04615	COG1295	ribonuclease BN
DI291_04620	COG0477	Major facilitator Superfamily
DI291_04630	COG0387	Pfam Sodium calcium exchanger
DI291_04640	COG0535	radical SAM domain protein
DI291_04650	COG0726	polysaccharide deacetylase
DI291_04655	COG0371	Dehydrogenase
DI291_04665	COG0598	Magnesium transport protein CorA
DI291_04670	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DI291_04675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DI291_04680	COG4637	Psort location Cytoplasmic, score
DI291_0470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DI291_04705	COG1819	glycosyl
DI291_04715	COG0477	Major facilitator Superfamily
DI291_04725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_04725	COG1263	PTS System
DI291_04730	COG3711	transcriptional antiterminator
DI291_04735	COG0288	reversible hydration of carbon dioxide
DI291_04740	COG3002	Belongs to the UPF0753 family
DI291_04745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DI291_0475	COG1376	ErfK ybiS ycfS ynhG family protein
DI291_04750	COG5609	conserved protein (DUF2294)
DI291_04760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DI291_04765	COG0022	dehydrogenase e1 component
DI291_04770	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_04775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DI291_04780	COG3284	Transcriptional regulator
DI291_04785	COG1742	UPF0060 membrane protein
DI291_04790	COG1486	melibiose metabolic process
DI291_04795	COG1737	Transcriptional regulator
DI291_04800	COG1263	PTS System
DI291_04800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_04815	COG1733	regulation of RNA biosynthetic process
DI291_04820	COG2259	Doxx family
DI291_04825	COG2514	catechol 2,3-dioxygenase activity
DI291_04835	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_04845	COG1653	transport
DI291_0485	COG0431	NADPH-dependent FMN reductase
DI291_04850	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_04855	COG1051	belongs to the nudix hydrolase family
DI291_04865	COG0392	lysyltransferase activity
DI291_04865	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DI291_04870	COG0384	phenazine biosynthesis protein PhzF
DI291_04875	COG0778	Nitroreductase
DI291_04895	COG1090	epimerase
DI291_04900	COG2137	regulation of response to DNA damage stimulus
DI291_04925	COG0463	Glycosyl transferase, family 2
DI291_04935	COG4485	Bacterial membrane protein, YfhO
DI291_04940	COG1988	membrane-bound metal-dependent
DI291_04945	COG1194	a g-specific adenine glycosylase
DI291_04955	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_04970	COG3557	Belongs to the UPF0374 family
DI291_04975	COG1132	(ABC) transporter
DI291_04980	COG0444	Belongs to the ABC transporter superfamily
DI291_04985	COG4608	Belongs to the ABC transporter superfamily
DI291_04990	COG0747	negative chemotaxis
DI291_04995	COG0601	transmembrane transport
DI291_05000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_05005	COG4129	membrane
DI291_05010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DI291_05015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DI291_05020	COG0735	belongs to the Fur family
DI291_05150	COG0582	viral genome integration into host DNA
DI291_05215	COG0457	Tetratricopeptide repeat
DI291_05220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DI291_05240	COG0710	3-dehydroquinate dehydratase activity
DI291_05245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DI291_05250	COG1116	anion transmembrane transporter activity
DI291_05255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DI291_05260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DI291_05265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_05275	COG1476	TRANSCRIPTIONal
DI291_05285	COG1131	(ABC) transporter
DI291_0530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_05305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DI291_05315	COG3382	B3 4 domain protein
DI291_05320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DI291_05330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DI291_05335	COG0789	Transcriptional regulator
DI291_05340	COG1664	Polymer-forming cytoskeletal
DI291_05345	COG1664	Polymer-forming cytoskeletal
DI291_0535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_05350	COG2766	serine protein kinase
DI291_05355	COG2718	Belongs to the UPF0229 family
DI291_05360	COG1566	PFAM secretion protein HlyD family protein
DI291_05365	COG2814	Major facilitator Superfamily
DI291_05370	COG0655	NAD(P)H dehydrogenase (quinone) activity
DI291_05385	COG1725	Transcriptional regulator
DI291_05390	COG1131	(ABC) transporter
DI291_05395	COG1131	(ABC) transporter
DI291_0540	COG1120	ATPase activity
DI291_05400	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DI291_05405	COG1278	Cold shock
DI291_05410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DI291_05415	COG2011	ABC-type metal ion transport system permease component
DI291_05420	COG1464	Belongs to the NlpA lipoprotein family
DI291_05425	COG1823	symporter activity
DI291_0545	COG0523	cobalamin synthesis protein
DI291_05450	COG5577	PFAM Coat F domain
DI291_05460	COG5002	protein histidine kinase activity
DI291_05465	COG4085	toxin activity
DI291_05465	COG1525	nuclease
DI291_05465	COG0737	Belongs to the 5'-nucleotidase family
DI291_05470	COG3764	Sortase (surface protein transpeptidase)
DI291_05475	COG0564	pseudouridine synthase activity
DI291_05485	COG0517	IMP dehydrogenase activity
DI291_05490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DI291_05495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DI291_05495	COG3153	acetyltransferase
DI291_0550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DI291_05500	COG0488	(ABC) transporter
DI291_05505	COG2116	formate transmembrane transporter activity
DI291_05520	COG0604	alcohol dehydrogenase
DI291_05525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DI291_05530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DI291_05535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DI291_05540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DI291_05545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DI291_0555	COG0113	porphobilinogen synthase activity
DI291_05560	COG2203	Gaf domain
DI291_05560	COG4585	Histidine kinase
DI291_05565	COG2197	response regulator
DI291_05570	COG0431	NADPH-dependent FMN reductase
DI291_05585	COG1959	2 iron, 2 sulfur cluster binding
DI291_05590	COG1017	nitric oxide dioxygenase activity
DI291_05590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DI291_05595	COG2719	SpoVR family
DI291_0560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DI291_05600	COG0791	NLP P60 protein
DI291_05600	COG1388	LysM domain
DI291_05605	COG0583	DNA-binding transcription factor activity
DI291_05610	COG0372	Belongs to the citrate synthase family
DI291_05615	COG2133	pyrroloquinoline quinone binding
DI291_05620	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_05625	COG0733	neurotransmitter:sodium symporter activity
DI291_05635	COG2207	Transcriptional regulator
DI291_05635	COG3708	Transcriptional regulator
DI291_05640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_05660	COG1595	DNA-templated transcription, initiation
DI291_05665	COG0662	Cupin 2, conserved barrel domain protein
DI291_05670	COG0667	Aldo Keto reductase
DI291_05675	COG0204	Acyl-transferase
DI291_05680	COG3152	Membrane
DI291_05695	COG1253	flavin adenine dinucleotide binding
DI291_0570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DI291_05700	COG0789	Transcriptional regulator
DI291_05705	COG1253	flavin adenine dinucleotide binding
DI291_05725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DI291_05730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DI291_05735	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_05745	COG0668	transmembrane transport
DI291_05750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DI291_05760	COG0726	polysaccharide deacetylase
DI291_05770	COG1757	Na H antiporter
DI291_05775	COG2017	converts alpha-aldose to the beta-anomer
DI291_05800	COG0589	response to stress
DI291_05805	COG1132	(ABC) transporter
DI291_05810	COG1132	(ABC) transporter
DI291_05815	COG0702	epimerase
DI291_05830	COG3842	ATPase activity
DI291_05835	COG2508	Transcriptional regulator
DI291_05845	COG0189	ligase activity
DI291_05850	COG0189	ligase activity
DI291_05855	COG4399	Belongs to the UPF0754 family
DI291_05860	COG3679	Belongs to the UPF0342 family
DI291_05870	COG0561	phosphatase activity
DI291_05875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DI291_05880	COG1024	Enoyl-CoA hydratase
DI291_05885	COG0457	Tetratricopeptide repeat
DI291_05900	COG4152	abc transporter atp-binding protein
DI291_05905	COG1668	transmembrane transport
DI291_05910	COG0420	3'-5' exonuclease activity
DI291_05915	COG4717	serine-type aminopeptidase activity
DI291_05920	COG3481	metal-dependent phosphohydrolase, HD sub domain
DI291_05930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DI291_05960	COG1846	Transcriptional regulator
DI291_05965	COG4980	gas vesicle protein
DI291_05980	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DI291_05985	COG0537	adenosine 5'-monophosphoramidase activity
DI291_05995	COG1131	(ABC) transporter
DI291_06000	COG4473	ABC transporter
DI291_06010	COG1473	amidohydrolase
DI291_06015	COG3069	C4-dicarboxylate transmembrane transporter activity
DI291_06020	COG2329	Antibiotic biosynthesis monooxygenase
DI291_06025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_06030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DI291_06035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DI291_06040	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DI291_06045	COG1309	transcriptional regulator
DI291_06050	COG1511	domain protein
DI291_06055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI291_06060	COG1363	Peptidase, m42
DI291_06070	COG1301	dicarboxylic acid transport
DI291_06080	COG1234	tRNA 3'-trailer cleavage
DI291_06085	COG0095	Lipoate-protein ligase
DI291_06090	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_06100	COG1396	sequence-specific DNA binding
DI291_06115	COG0501	Belongs to the peptidase M48B family
DI291_06125	COG0697	spore germination
DI291_06130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DI291_06135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_06140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_06145	COG0406	alpha-ribazole phosphatase activity
DI291_0615	COG3152	Membrane
DI291_06165	COG0840	transmembrane signaling receptor activity
DI291_06170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DI291_06170	COG0723	plastoquinol--plastocyanin reductase activity
DI291_06175	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_06185	COG4903	ComK protein
DI291_06195	COG0398	Pfam SNARE associated Golgi protein
DI291_06200	COG0681	Belongs to the peptidase S26 family
DI291_06210	COG1404	Belongs to the peptidase S8 family
DI291_06220	COG2508	Transcriptional regulator
DI291_06225	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DI291_06230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DI291_06235	COG3257	ureidoglycine aminohydrolase activity
DI291_06240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DI291_06245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DI291_06250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DI291_06255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DI291_06265	COG0549	Belongs to the carbamate kinase family
DI291_06270	COG2814	Major facilitator Superfamily
DI291_06280	COG0457	Tetratricopeptide repeat
DI291_06300	COG3180	Ammonia monooxygenase
DI291_06315	COG3546	catalase activity
DI291_06320	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_06325	COG2814	Major facilitator Superfamily
DI291_06325	COG0477	Major facilitator Superfamily
DI291_06330	COG4533	DNA binding
DI291_06340	COG5002	protein histidine kinase activity
DI291_06345	COG0745	RESPONSE REGULATOR receiver
DI291_06350	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DI291_06355	COG0725	ABC transporter, periplasmic molybdate-binding protein
DI291_06360	COG4149	molybdate abc transporter
DI291_06365	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DI291_06370	COG1074	ATP-dependent DNA helicase activity
DI291_06375	COG0420	3'-5' exonuclease activity
DI291_06380	COG0419	ATPase involved in DNA repair
DI291_06425	COG5337	Spore coat protein CotH
DI291_06435	COG0179	Fumarylacetoacetate (FAA) hydrolase
DI291_06460	COG0367	asparagine synthase
DI291_06465	COG0004	ammonium transporteR
DI291_06470	COG0347	Belongs to the P(II) protein family
DI291_06475	COG0534	Mate efflux family protein
DI291_06480	COG2207	Transcriptional regulator
DI291_06480	COG1917	Cupin 2, conserved barrel domain protein
DI291_06490	COG1609	Transcriptional regulator
DI291_06495	COG0673	inositol 2-dehydrogenase activity
DI291_06510	COG0697	spore germination
DI291_06515	COG1279	arginine transmembrane transporter activity
DI291_06520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_06530	COG0076	glutamate decarboxylase activity
DI291_06555	COG2153	protein acetylation
DI291_06560	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_06565	COG2378	regulation of single-species biofilm formation
DI291_06570	COG1410	methionine synthase
DI291_06570	COG0646	methionine synthase
DI291_06575	COG0646	methionine synthase
DI291_06575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DI291_06580	COG1666	GTP binding
DI291_06585	COG2996	Protein conserved in bacteria
DI291_06600	COG1307	EDD domain protein, DegV family
DI291_06605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_06615	COG0516	GMP reductase activity
DI291_06625	COG0561	phosphatase activity
DI291_06630	COG1073	alpha beta
DI291_06635	COG2151	metal-sulfur cluster biosynthetic enzyme
DI291_06645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DI291_06650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DI291_06655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DI291_06660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DI291_06665	COG0505	Belongs to the CarA family
DI291_06670	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DI291_06675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DI291_06680	COG1968	undecaprenyl-diphosphatase activity
DI291_06695	COG2267	carboxylic ester hydrolase activity
DI291_06705	COG1744	ABC transporter substrate-binding protein PnrA-like
DI291_06720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI291_06725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DI291_06730	COG5504	Zn-dependent protease
DI291_06735	COG0444	Belongs to the ABC transporter superfamily
DI291_06740	COG4608	Belongs to the ABC transporter superfamily
DI291_06750	COG0601	transmembrane transport
DI291_06755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_06780	COG0180	Tryptophanyl-tRNA synthetase
DI291_06790	COG4166	transmembrane transport
DI291_06795	COG0601	transmembrane transport
DI291_06800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_06805	COG0444	Belongs to the ABC transporter superfamily
DI291_06810	COG4608	Belongs to the ABC transporter superfamily
DI291_06815	COG0456	acetyltransferase
DI291_06820	COG1393	Belongs to the ArsC family
DI291_06825	COG0861	Integral membrane protein TerC family
DI291_06830	COG4862	establishment of competence for transformation
DI291_06855	COG4565	transcriptional regulatory protein
DI291_06860	COG3290	protein histidine kinase activity
DI291_06865	COG4469	Competence protein
DI291_06870	COG1164	Oligoendopeptidase f
DI291_06880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DI291_06885	COG2346	COG2346, Truncated hemoglobins
DI291_06890	COG0741	lytic transglycosylase activity
DI291_06895	COG4116	CYTH
DI291_0690	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_0690	COG2247	cell wall binding repeat
DI291_06905	COG2357	RelA SpoT domain protein
DI291_06910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DI291_06915	COG0564	pseudouridine synthase activity
DI291_06920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DI291_06925	COG0475	glutathione-regulated potassium exporter activity
DI291_06925	COG0569	domain protein
DI291_06930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DI291_06935	COG0352	thiamine-phosphate diphosphorylase activity
DI291_06945	COG2104	thiamine diphosphate biosynthetic process
DI291_06950	COG2022	thiamine diphosphate biosynthetic process
DI291_06955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DI291_06960	COG0351	phosphomethylpyrimidine kinase
DI291_06965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DI291_07020	COG0210	DNA helicase
DI291_07030	COG0586	Pfam SNARE associated Golgi protein
DI291_07035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_07040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DI291_07045	COG2246	polysaccharide biosynthetic process
DI291_0705	COG1316	TRANSCRIPTIONal
DI291_07050	COG2153	protein acetylation
DI291_07055	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DI291_07060	COG2382	esterase
DI291_07080	COG0626	cystathionine gamma-synthase activity
DI291_07085	COG0626	cystathionine gamma-synthase activity
DI291_07090	COG5505	Protein of unknown function (DUF819)
DI291_0710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DI291_07105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_07115	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_0715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DI291_07190	COG0110	maltose O-acetyltransferase activity
DI291_0720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DI291_07200	COG0583	DNA-binding transcription factor activity
DI291_07205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DI291_07210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DI291_07215	COG0583	DNA-binding transcription factor activity
DI291_07220	COG0697	spore germination
DI291_07225	COG0346	lactoylglutathione lyase activity
DI291_07235	COG3584	3D domain protein
DI291_07235	COG1388	LysM domain
DI291_07240	COG2814	Major facilitator Superfamily
DI291_07245	COG1309	transcriptional regulator
DI291_0725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DI291_07260	COG4195	phage-related replication protein
DI291_07265	COG2856	Zn peptidase
DI291_07270	COG1396	sequence-specific DNA binding
DI291_07285	COG1522	sequence-specific DNA binding
DI291_07290	COG1484	DNA-dependent DNA replication
DI291_0730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DI291_07305	COG1595	DNA-templated transcription, initiation
DI291_07310	COG5484	DNA packaging
DI291_07310	COG3728	DNA packaging
DI291_07315	COG1783	phage Terminase large subunit
DI291_07320	COG5518	Phage portal protein
DI291_07325	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DI291_07330	COG4653	Phage capsid family
DI291_0735	COG0438	transferase activity, transferring glycosyl groups
DI291_07380	COG5280	Phage tail tape measure protein TP901
DI291_07380	COG3953	SLT domain
DI291_07385	COG1652	LysM domain
DI291_07390	COG4193	domain, Protein
DI291_0740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DI291_07400	COG3628	GPW Gp25 family protein
DI291_07405	COG3299	homolog of phage Mu protein gp47
DI291_07410	COG3778	Protein conserved in bacteria
DI291_07445	COG1802	Transcriptional regulator
DI291_07450	COG1063	alcohol dehydrogenase
DI291_07455	COG1312	Catalyzes the dehydration of D-mannonate
DI291_07460	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_07465	COG1063	alcohol dehydrogenase
DI291_07470	COG2271	Major facilitator Superfamily
DI291_07485	COG0306	phosphate transporter
DI291_07490	COG1392	Phosphate transport regulator
DI291_07495	COG0405	Gamma-glutamyltransferase
DI291_0750	COG1682	transport, permease protein
DI291_07500	COG5578	integral membrane protein
DI291_07505	COG2972	Histidine kinase
DI291_07510	COG4753	response regulator
DI291_07510	COG2207	Transcriptional regulator
DI291_07515	COG1653	transport
DI291_07520	COG1175	transmembrane transport
DI291_07525	COG0395	ABC-type sugar transport system, permease component
DI291_07530	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DI291_07535	COG2207	Transcriptional regulator
DI291_07540	COG2755	lipolytic protein G-D-S-L family
DI291_0755	COG1134	teichoic acid transport
DI291_07550	COG5578	integral membrane protein
DI291_07555	COG3401	FG-GAP repeat protein
DI291_07565	COG2755	lipolytic protein G-D-S-L family
DI291_07570	COG3401	FG-GAP repeat protein
DI291_07575	COG0667	Aldo Keto reductase
DI291_07580	COG2755	lipolytic protein G-D-S-L family
DI291_07585	COG1874	Beta-galactosidase
DI291_07595	COG1653	transport
DI291_0760	COG4193	domain, Protein
DI291_07600	COG4209	transmembrane transport
DI291_07605	COG0395	ABC-type sugar transport system, permease component
DI291_07610	COG0531	amino acid
DI291_07615	COG0346	lactoylglutathione lyase activity
DI291_07620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_07625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DI291_07630	COG2362	D-Aminopeptidase
DI291_07635	COG0601	transmembrane transport
DI291_07640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_07645	COG0444	Belongs to the ABC transporter superfamily
DI291_07650	COG4166	transmembrane transport
DI291_07655	COG1619	proteins homologs of microcin C7 resistance protein MccF
DI291_07660	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_07665	COG0791	NLP P60 protein
DI291_07670	COG4608	Belongs to the ABC transporter superfamily
DI291_07680	COG1834	amidinotransferase
DI291_07685	COG1607	acyl-coa hydrolase
DI291_07690	COG2323	membrane
DI291_07695	COG3866	Pectate lyase
DI291_07715	COG2318	DinB family
DI291_07720	COG2076	Multidrug Resistance protein
DI291_07725	COG2076	Multidrug Resistance protein
DI291_07730	COG0788	formyltetrahydrofolate deformylase activity
DI291_07740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DI291_07745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DI291_07750	COG1764	response to oxidative stress
DI291_07755	COG1846	Transcriptional regulator
DI291_07760	COG1764	response to oxidative stress
DI291_07770	COG0590	tRNA wobble adenosine to inosine editing
DI291_07775	COG0406	alpha-ribazole phosphatase activity
DI291_07790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DI291_07795	COG1404	Belongs to the peptidase S8 family
DI291_0780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DI291_07805	COG2239	Acts as a magnesium transporter
DI291_07815	COG0789	Transcriptional regulator
DI291_07830	COG1846	Transcriptional regulator
DI291_07835	COG1793	dna ligase
DI291_07835	COG3285	dna ligase
DI291_07840	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DI291_07845	COG5001	Diguanylate cyclase
DI291_07845	COG3300	MHYT domain
DI291_0785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DI291_07850	COG0586	Pfam SNARE associated Golgi protein
DI291_07855	COG0861	Integral membrane protein TerC family
DI291_07860	COG1191	sigma factor activity
DI291_07880	COG0501	Belongs to the peptidase M48B family
DI291_07885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DI291_07890	COG0768	penicillin binding
DI291_0790	COG0438	transferase activity, transferring glycosyl groups
DI291_07905	COG3594	Acyltransferase
DI291_07910	COG5002	protein histidine kinase activity
DI291_07915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DI291_07920	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DI291_07925	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DI291_07930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DI291_07935	COG0436	Aminotransferase
DI291_07940	COG1850	ribulose-bisphosphate carboxylase activity
DI291_07945	COG0235	Class ii aldolase
DI291_07945	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DI291_07950	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DI291_07950	COG0235	Class ii aldolase
DI291_07955	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DI291_07960	COG0346	lactoylglutathione lyase activity
DI291_07965	COG3339	Conserved Protein
DI291_07975	COG3852	Histidine kinase
DI291_07980	COG1846	Transcriptional regulator
DI291_07985	COG1360	Flagellar Motor Protein
DI291_07990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DI291_07995	COG0542	response to heat
DI291_0800	COG4193	domain, Protein
DI291_08000	COG3949	Membrane
DI291_08005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DI291_08010	COG0720	synthase
DI291_08015	COG0602	queuosine metabolic process
DI291_08020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DI291_08035	COG3739	integral membrane protein
DI291_08040	COG3655	Transcriptional regulator
DI291_0805	COG2910	NAD(P)H-binding
DI291_08075	COG4873	Protein conserved in bacteria
DI291_08085	COG3773	Cell wall hydrolase
DI291_08090	COG2244	polysaccharide biosynthetic process
DI291_08095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_08100	COG2217	Heavy metal translocating P-type atpase
DI291_08105	COG0006	proline dipeptidase activity
DI291_08115	COG1609	Transcriptional regulator
DI291_08120	COG3711	transcriptional antiterminator
DI291_08125	COG2190	(PTS) system
DI291_08125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_08125	COG1263	PTS System
DI291_08130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_08135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DI291_08145	COG1533	DNA photolyase activity
DI291_0815	COG0842	Transport permease protein
DI291_08150	COG0456	acetyltransferase
DI291_08155	COG0840	transmembrane signaling receptor activity
DI291_08160	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_08165	COG2084	Dehydrogenase
DI291_08170	COG2340	Cysteine-rich secretory protein family
DI291_08175	COG0768	penicillin binding
DI291_08180	COG4191	Histidine kinase
DI291_08185	COG0436	Aminotransferase
DI291_08190	COG1714	RDD family
DI291_0820	COG4585	Histidine kinase
DI291_08200	COG0784	Response regulator, receiver
DI291_08200	COG0835	chemotaxis
DI291_08210	COG2814	Major facilitator Superfamily
DI291_08215	COG1376	ErfK ybiS ycfS ynhG family protein
DI291_08220	COG1408	metallophosphoesterase
DI291_08225	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_08230	COG2200	EAL domain
DI291_08245	COG4703	Protein of unknown function (DUF1797)
DI291_0825	COG2197	response regulator
DI291_08250	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DI291_08260	COG0517	IMP dehydrogenase activity
DI291_08265	COG0583	DNA-binding transcription factor activity
DI291_08270	COG0716	FMN binding
DI291_08280	COG0716	FMN binding
DI291_08285	COG2171	N-acyltransferase activity
DI291_08290	COG1473	amidohydrolase
DI291_08300	COG0450	alkyl hydroperoxide reductase
DI291_08305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_08320	COG0746	molybdenum cofactor guanylyltransferase activity
DI291_08325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DI291_08330	COG0303	'Molybdopterin
DI291_08335	COG1763	Mo-molybdopterin cofactor biosynthetic process
DI291_08340	COG0314	molybdopterin synthase activity
DI291_08345	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DI291_08355	COG1132	(ABC) transporter
DI291_08360	COG1132	(ABC) transporter
DI291_08370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DI291_08375	COG1136	(ABC) transporter
DI291_08380	COG0577	efflux transmembrane transporter activity
DI291_08390	COG1349	DNA-binding transcription factor activity
DI291_08395	COG1105	Belongs to the carbohydrate kinase PfkB family
DI291_08400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_08400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_08400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_08420	COG0488	(ABC) transporter
DI291_08430	COG2309	aminopeptidase activity
DI291_08440	COG1077	Cell shape determining protein MreB Mrl
DI291_08445	COG2002	toxin-antitoxin pair type II binding
DI291_08450	COG3852	Histidine kinase
DI291_08455	COG0569	domain protein
DI291_08460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DI291_08465	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DI291_08470	COG5503	Protein of unknown function (DUF1447)
DI291_08480	COG0561	phosphatase activity
DI291_08485	COG0242	peptide deformylase activity
DI291_08495	COG0497	DNA recombination
DI291_08500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DI291_08505	COG0022	dehydrogenase e1 component
DI291_08510	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_08515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DI291_08520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_08530	COG1982	Orn Lys Arg decarboxylase major
DI291_08540	COG4476	Belongs to the UPF0223 family
DI291_08545	COG4493	Belongs to the UPF0637 family
DI291_08555	COG0483	inositol monophosphate 1-phosphatase activity
DI291_08575	COG1595	DNA-templated transcription, initiation
DI291_08590	COG1217	gtp-binding protein TYPA
DI291_08600	COG1846	Transcriptional regulator
DI291_08605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DI291_08610	COG4896	Protein conserved in bacteria
DI291_08620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DI291_08625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DI291_08630	COG2066	Belongs to the glutaminase family
DI291_08635	COG4838	Belongs to the UPF0358 family
DI291_08640	COG0772	Belongs to the SEDS family
DI291_08645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DI291_08650	COG1612	heme a metabolic process
DI291_08655	COG0109	protoheme IX farnesyltransferase activity
DI291_08660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DI291_08660	COG2010	Cytochrome c
DI291_08665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DI291_08670	COG1845	cytochrome c oxidase, subunit III
DI291_08675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DI291_08680	COG3336	cytochrome c oxidase
DI291_08690	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DI291_08695	COG2340	Cysteine-rich secretory protein family
DI291_08710	COG3679	Belongs to the UPF0342 family
DI291_08715	COG4471	UPF0298 protein
DI291_08720	COG0742	ribosomal rna small subunit methyltransferase
DI291_08725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DI291_08730	COG3314	Sporulation integral membrane protein YlbJ
DI291_08735	COG3480	Lon protease (S16) C-terminal proteolytic domain
DI291_08740	COG1323	Belongs to the UPF0348 family
DI291_08745	COG1399	metal-binding, possibly nucleic acid-binding protein
DI291_08750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DI291_08760	COG0454	-acetyltransferase
DI291_08765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DI291_08770	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DI291_08775	COG2001	Belongs to the MraZ family
DI291_08780	COG0275	rRNA processing
DI291_08785	COG4839	cell division protein FtsL
DI291_08790	COG0768	penicillin binding
DI291_08795	COG0768	penicillin binding
DI291_08800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DI291_08805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DI291_08810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DI291_08815	COG0772	Belongs to the SEDS family
DI291_08820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_08825	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DI291_08830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DI291_08835	COG3879	Bacterial protein of unknown function (DUF881)
DI291_08840	COG3879	Bacterial protein of unknown function (DUF881)
DI291_08845	COG3856	small basic protein
DI291_08850	COG0849	cell division
DI291_08855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DI291_08860	COG4412	M6 family metalloprotease domain protein
DI291_08860	COG1404	Belongs to the peptidase S8 family
DI291_08865	COG1404	Belongs to the peptidase S8 family
DI291_08865	COG4412	M6 family metalloprotease domain protein
DI291_08875	COG1191	sigma factor activity
DI291_08880	COG1191	sigma factor activity
DI291_08885	COG1119	ATPase activity
DI291_08890	COG0500	methyltransferase
DI291_08895	COG1873	PFAM PRC-barrel domain
DI291_08900	COG1496	oxidoreductase activity
DI291_08905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DI291_08910	COG1799	cell septum assembly
DI291_08915	COG0762	integral membrane protein
DI291_08920	COG2302	S4 RNA-binding domain
DI291_08925	COG3599	regulation of cell shape
DI291_08930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DI291_08935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DI291_08940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DI291_08945	COG0564	pseudouridine synthase activity
DI291_08955	COG2233	PERMEase
DI291_08960	COG0540	Belongs to the ATCase OTCase family
DI291_08965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DI291_08970	COG0505	Belongs to the CarA family
DI291_08975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DI291_08980	COG0543	2 iron, 2 sulfur cluster binding
DI291_08985	COG0167	dihydroorotate dehydrogenase activity
DI291_08990	COG0284	orotidine-5'-phosphate decarboxylase activity
DI291_08995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DI291_09005	COG0175	sulfate reduction
DI291_09010	COG0306	phosphate transporter
DI291_09015	COG2046	Belongs to the sulfate adenylyltransferase family
DI291_09020	COG0529	Catalyzes the synthesis of activated sulfate
DI291_09025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DI291_09030	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DI291_09035	COG1648	precorrin-2 dehydrogenase activity
DI291_09045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DI291_09050	COG1561	YicC-like family, N-terminal region
DI291_09055	COG2052	Domain of unknown function (DUF370)
DI291_09060	COG0194	GDP metabolic process
DI291_09065	COG1758	RNA polymerase activity
DI291_09070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DI291_09075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DI291_09080	COG0242	peptide deformylase activity
DI291_09085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DI291_09090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DI291_09090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DI291_09095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DI291_09100	COG0631	protein serine/threonine phosphatase activity
DI291_09105	COG0515	serine threonine protein kinase
DI291_09105	COG2815	serine threonine protein kinase
DI291_09110	COG1162	GTPase activity
DI291_09115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DI291_09120	COG1564	THIamine pyrophosphokinase
DI291_09130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DI291_09135	COG1302	Protein conserved in bacteria
DI291_09140	COG1461	Dihydroxyacetone kinase
DI291_09145	COG1760	l-serine dehydratase
DI291_09150	COG1760	l-serine dehydratase
DI291_09155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DI291_09160	COG1349	DNA-binding transcription factor activity
DI291_09165	COG0416	fatty acid biosynthetic process
DI291_09170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DI291_09175	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DI291_09185	COG0571	ribonuclease III activity
DI291_09190	COG1196	nuclear chromosome segregation
DI291_09195	COG0552	protein localization to endoplasmic reticulum
DI291_09200	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DI291_09205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DI291_09210	COG0228	four-way junction DNA binding
DI291_09215	COG1837	Belongs to the UPF0109 family
DI291_09225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DI291_09230	COG0336	Belongs to the RNA methyltransferase TrmD family
DI291_09235	COG0335	large ribosomal subunit rRNA binding
DI291_09240	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DI291_09245	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DI291_09255	COG2257	FlhB HrpN YscU SpaS Family
DI291_09260	COG0045	succinate-CoA ligase (ADP-forming) activity
DI291_09265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DI291_09270	COG0758	DNA mediated transformation
DI291_09275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DI291_09280	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DI291_09285	COG4974	Belongs to the 'phage' integrase family
DI291_09290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DI291_09295	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DI291_09300	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DI291_09305	COG1815	bacterial-type flagellum-dependent cell motility
DI291_09310	COG1558	bacterial-type flagellum-dependent cell motility
DI291_09315	COG1677	Flagellar hook-basal body complex protein FliE
DI291_09320	COG1766	The M ring may be actively involved in energy transduction
DI291_09325	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DI291_09330	COG1317	bacterial-type flagellum organization
DI291_09335	COG1157	protein secretion by the type III secretion system
DI291_09340	COG2882	bacterial-type flagellum organization
DI291_09345	COG3334	PFAM MgtE intracellular
DI291_09350	COG3144	bacterial-type flagellum assembly
DI291_09355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DI291_09360	COG4786	Flagellar basal body rod
DI291_09365	COG1582	Flagellar protein (FlbD)
DI291_09370	COG1580	Controls the rotational direction of flagella during chemotaxis
DI291_09375	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DI291_09380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DI291_09380	COG1776	CheC inhibitor of MCP methylation
DI291_09385	COG2201	protein-glutamate methylesterase activity
DI291_09390	COG3190	flagellar
DI291_09395	COG1338	Plays a role in the flagellum-specific transport system
DI291_09400	COG1987	bacterial-type flagellum assembly
DI291_09405	COG1684	flagellar biosynthetic protein fliR
DI291_09410	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DI291_09415	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DI291_09420	COG1419	protein localization to endoplasmic reticulum
DI291_09425	COG0455	bacterial-type flagellum organization
DI291_09430	COG2201	protein-glutamate methylesterase activity
DI291_09435	COG2198	Histidine kinase
DI291_09435	COG0643	Histidine kinase
DI291_09440	COG0835	chemotaxis
DI291_09445	COG1776	CheC inhibitor of MCP methylation
DI291_09450	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DI291_09455	COG1191	sigma factor activity
DI291_09465	COG0052	Belongs to the universal ribosomal protein uS2 family
DI291_09470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DI291_09475	COG0528	UMP kinase activity
DI291_09480	COG0233	cytoplasmic translational termination
DI291_09485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DI291_09490	COG4589	Belongs to the CDS family
DI291_09495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DI291_09500	COG0750	zinc metalloprotease
DI291_09505	COG0442	prolyl-tRNA aminoacylation
DI291_09510	COG2176	DNA-directed DNA polymerase activity
DI291_09535	COG0779	Required for maturation of 30S ribosomal subunits
DI291_09540	COG0195	Participates in both transcription termination and antitermination
DI291_09545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DI291_09550	COG1358	cellular component organization or biogenesis
DI291_09555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DI291_09560	COG1550	Protein conserved in bacteria
DI291_09565	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DI291_09570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DI291_09575	COG0196	riboflavin kinase activity
DI291_09580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DI291_09585	COG1185	polyribonucleotide nucleotidyltransferase activity
DI291_09590	COG0726	polysaccharide deacetylase
DI291_09595	COG0612	Peptidase, M16
DI291_09600	COG1873	PFAM PRC-barrel domain
DI291_09605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_09610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DI291_09615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DI291_09620	COG0527	aspartate kinase activity
DI291_09630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DI291_09635	COG0740	serine-type endopeptidase activity
DI291_09645	COG4980	gas vesicle protein
DI291_09645	COG1674	ftsk spoiiie
DI291_09650	COG2188	Transcriptional regulator
DI291_09655	COG2814	Major facilitator Superfamily
DI291_09660	COG0612	Peptidase, M16
DI291_09665	COG0612	Peptidase, M16
DI291_09670	COG0300	oxidoreductase activity
DI291_09685	COG1426	Protein conserved in bacteria
DI291_09690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DI291_09695	COG1546	Belongs to the CinA family
DI291_09695	COG1058	Belongs to the CinA family
DI291_09705	COG1418	mRNA catabolic process
DI291_09710	COG1692	metallophosphoesterase
DI291_09715	COG2359	stage V sporulation protein S
DI291_09725	COG1063	alcohol dehydrogenase
DI291_09735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI291_09740	COG4550	Control of competence regulator ComK, YlbF/YmcA
DI291_09750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DI291_09755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DI291_09815	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DI291_09820	COG0457	Tetratricopeptide repeat
DI291_09845	COG0457	Tetratricopeptide repeat
DI291_09865	COG0523	cobalamin synthesis protein
DI291_09885	COG1231	oxidoreductase activity
DI291_09890	COG3619	membrane
DI291_09895	COG3263	regulation of cellular component size
DI291_09900	COG2814	Major facilitator Superfamily
DI291_09915	COG0393	Putative heavy-metal-binding
DI291_09920	COG0398	Pfam SNARE associated Golgi protein
DI291_09925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DI291_09930	COG1819	glycosyl
DI291_09935	COG0531	amino acid
DI291_09940	COG5577	PFAM Coat F domain
DI291_09950	COG1388	LysM domain
DI291_09950	COG3858	chitin binding
DI291_09955	COG1309	transcriptional regulator
DI291_09960	COG3631	Ketosteroid isomerase-related protein
DI291_09965	COG0702	epimerase
DI291_09975	COG1764	response to oxidative stress
DI291_09980	COG2076	Multidrug Resistance protein
DI291_09985	COG2076	Multidrug Resistance protein
DI291_10000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DI291_10005	COG1923	regulation of RNA biosynthetic process
DI291_10020	COG1780	Probably involved in ribonucleotide reductase function
DI291_10025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DI291_10030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DI291_10035	COG4112	unkown
DI291_10050	COG0735	belongs to the Fur family
DI291_10055	COG1802	Transcriptional regulator
DI291_10060	COG0697	spore germination
DI291_10095	COG1309	transcriptional regulator
DI291_10130	COG4282	regulation of fungal-type cell wall biogenesis
DI291_10135	COG5444	nuclease activity
DI291_10175	COG4413	Urea transporter
DI291_10180	COG0831	urea catabolic process
DI291_10185	COG0832	Belongs to the urease beta subunit family
DI291_10195	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DI291_10200	COG0830	nickel cation binding
DI291_10205	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DI291_10210	COG0829	nickel cation binding
DI291_10220	COG1695	Transcriptional regulator
DI291_10240	COG0464	growth
DI291_10245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DI291_10250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DI291_10255	COG0789	Transcriptional regulator
DI291_10260	COG0174	glutamine synthetase
DI291_10280	COG0174	glutamine synthetase
DI291_10325	COG1073	alpha beta
DI291_10360	COG1309	transcriptional regulator
DI291_10365	COG2076	Multidrug Resistance protein
DI291_10370	COG2076	Multidrug Resistance protein
DI291_10375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_10390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_10395	COG3546	catalase activity
DI291_10420	COG1846	Transcriptional regulator
DI291_10430	COG0346	lactoylglutathione lyase activity
DI291_10435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DI291_10440	COG0655	NAD(P)H dehydrogenase (quinone) activity
DI291_10460	COG3209	COG3209 Rhs family protein
DI291_10470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DI291_10475	COG1388	LysM domain
DI291_10480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DI291_10485	COG4224	UPF0291 protein
DI291_10490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DI291_10500	COG3763	UPF0154 protein
DI291_10510	COG0785	Cytochrome C biogenesis protein
DI291_10515	COG2201	protein-glutamate methylesterase activity
DI291_10520	COG4846	Membrane protein involved in cytochrome C biogenesis
DI291_10530	COG0071	Belongs to the small heat shock protein (HSP20) family
DI291_10545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DI291_10550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_10570	COG0824	Thioesterase
DI291_10590	COG4841	protein insertion into membrane
DI291_10595	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DI291_10600	COG1832	CoA-binding protein
DI291_10605	COG0187	DNA topoisomerase II activity
DI291_10610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DI291_10615	COG1609	Transcriptional regulator
DI291_10630	COG2160	L-arabinose isomerase activity
DI291_10650	COG1115	amino acid carrier protein
DI291_10660	COG2181	nitrate reductase activity
DI291_10665	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DI291_10670	COG1140	nitrate reductase beta subunit
DI291_10675	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DI291_10690	COG0535	radical SAM domain protein
DI291_10695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DI291_10705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DI291_10710	COG2223	nitrite transmembrane transporter activity
DI291_10730	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DI291_10740	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DI291_10750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_10775	COG0477	Major facilitator Superfamily
DI291_10780	COG3420	alginic acid biosynthetic process
DI291_10785	COG1114	Component of the transport system for branched-chain amino acids
DI291_10815	COG1024	Enoyl-CoA hydratase
DI291_10820	COG1012	belongs to the aldehyde dehydrogenase family
DI291_10825	COG2084	Dehydrogenase
DI291_10830	COG1960	acyl-CoA dehydrogenase activity
DI291_10835	COG1482	cell wall glycoprotein biosynthetic process
DI291_10840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_10840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_10840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_10865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_10865	COG3711	transcriptional antiterminator
DI291_10880	COG1725	Transcriptional regulator
DI291_10885	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_10890	COG1312	Catalyzes the dehydration of D-mannonate
DI291_10905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DI291_10915	COG1609	Transcriptional regulator
DI291_10920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DI291_10925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DI291_10930	COG0640	Transcriptional regulator
DI291_10935	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DI291_10950	COG1649	PFAM Uncharacterised BCR, COG1649
DI291_10955	COG2404	hydrolase activity, acting on ester bonds
DI291_10960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DI291_10970	COG0438	transferase activity, transferring glycosyl groups
DI291_10975	COG2027	D-alanyl-D-alanine carboxypeptidase
DI291_10995	COG1309	transcriptional regulator
DI291_11000	COG1252	NADH dehydrogenase
DI291_11015	COG0166	Belongs to the GPI family
DI291_11025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI291_11030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DI291_11035	COG1024	Enoyl-CoA hydratase
DI291_11040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DI291_11045	COG0511	ligase activity, forming carbon-carbon bonds
DI291_11050	COG0439	Biotin carboxylase
DI291_11055	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DI291_11055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_11060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_11065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_11070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_11075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_11080	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_11085	COG1960	acyl-CoA dehydrogenase activity
DI291_11090	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_11095	COG1733	regulation of RNA biosynthetic process
DI291_11100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DI291_11105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DI291_11115	COG2323	membrane
DI291_11120	COG0306	phosphate transporter
DI291_11125	COG0175	sulfate reduction
DI291_11130	COG1809	phosphosulfolactate synthase activity
DI291_11135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_11140	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_11145	COG2814	Major facilitator Superfamily
DI291_11150	COG0463	Glycosyl transferase, family 2
DI291_11165	COG0493	'glutamate synthase
DI291_11170	COG0070	glutamate synthase
DI291_11170	COG0069	glutamate synthase activity
DI291_11170	COG0067	glutamate synthase
DI291_11175	COG0583	DNA-binding transcription factor activity
DI291_11200	COG1132	(ABC) transporter
DI291_11210	COG0300	oxidoreductase activity
DI291_11215	COG3848	Pyruvate phosphate dikinase
DI291_11215	COG0574	Belongs to the PEP-utilizing enzyme family
DI291_11220	COG0477	Major facilitator Superfamily
DI291_11225	COG0243	molybdopterin cofactor binding
DI291_11230	COG1846	Transcriptional regulator
DI291_11235	COG2814	Major facilitator Superfamily
DI291_11240	COG0531	amino acid
DI291_11250	COG0531	amino acid
DI291_11255	COG0531	amino acid
DI291_11260	COG0697	spore germination
DI291_11265	COG0488	(ABC) transporter
DI291_11270	COG0840	transmembrane signaling receptor activity
DI291_11275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_11280	COG1404	Belongs to the peptidase S8 family
DI291_11290	COG1309	transcriptional regulator
DI291_11295	COG1846	Transcriptional regulator
DI291_11325	COG1309	transcriptional regulator
DI291_11330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_11335	COG3708	Transcriptional regulator
DI291_11345	COG2378	regulation of single-species biofilm formation
DI291_11355	COG0640	Transcriptional regulator
DI291_11370	COG0531	amino acid
DI291_11375	COG0741	lytic transglycosylase activity
DI291_11380	COG1086	Polysaccharide biosynthesis protein
DI291_11395	COG0438	transferase activity, transferring glycosyl groups
DI291_11400	COG2322	membrane
DI291_11415	COG1619	proteins homologs of microcin C7 resistance protein MccF
DI291_11420	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_11425	COG3584	3D domain protein
DI291_11425	COG1388	LysM domain
DI291_11430	COG0514	ATP-dependent DNA helicase (RecQ)
DI291_11450	COG2315	Protein conserved in bacteria
DI291_11455	COG5444	nuclease activity
DI291_11460	COG2427	Protein of unknown function (DUF1641)
DI291_11465	COG3383	formate dehydrogenase (NAD+) activity
DI291_11510	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DI291_11545	COG2350	Protein conserved in bacteria
DI291_11570	COG0402	S-adenosylhomocysteine deaminase activity
DI291_11585	COG2267	carboxylic ester hydrolase activity
DI291_11600	COG1280	lysine exporter protein (LysE YggA)
DI291_11610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DI291_11620	COG3848	Pyruvate phosphate dikinase
DI291_11620	COG0574	Belongs to the PEP-utilizing enzyme family
DI291_11640	COG2318	DinB family
DI291_11645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DI291_11670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DI291_11685	COG1012	belongs to the aldehyde dehydrogenase family
DI291_11705	COG1657	PFAM Prenyltransferase squalene oxidase
DI291_11710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DI291_11720	COG0733	neurotransmitter:sodium symporter activity
DI291_11725	COG0385	Bile acid
DI291_11730	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_11735	COG0567	Dehydrogenase, E1 component
DI291_11740	COG4548	von Willebrand factor, type A
DI291_11745	COG0714	Associated with various cellular activities
DI291_11750	COG2032	superoxide dismutase activity
DI291_11755	COG0791	NLP P60 protein
DI291_11755	COG1388	LysM domain
DI291_11765	COG0534	Mate efflux family protein
DI291_11770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DI291_11775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DI291_11785	COG2962	Rard protein
DI291_11795	COG4305	rare lipoprotein A
DI291_11805	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_11810	COG1733	regulation of RNA biosynthetic process
DI291_11815	COG0778	Nitroreductase
DI291_11820	COG0400	carboxylic ester hydrolase activity
DI291_11830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_11835	COG0793	Belongs to the peptidase S41A family
DI291_11835	COG3409	Peptidoglycan-binding domain 1 protein
DI291_11840	COG2226	methyltransferase
DI291_11850	COG1876	peptidase activity
DI291_11855	COG0813	purine-nucleoside phosphorylase activity
DI291_11860	COG0701	Predicted permease
DI291_11880	COG0671	phosphoesterase, PA-phosphatase related
DI291_11895	COG4479	Belongs to the UPF0346 family
DI291_11905	COG1509	lysine 2,3-aminomutase activity
DI291_11910	COG0456	acetyltransferase
DI291_11915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DI291_11920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DI291_11925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DI291_11930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DI291_11945	COG0456	acetyltransferase
DI291_11950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DI291_11955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DI291_11960	COG1846	Transcriptional regulator
DI291_11970	COG3706	GGDEF domain
DI291_11975	COG0534	Mate efflux family protein
DI291_11990	COG4698	Protein conserved in bacteria
DI291_11995	COG2755	lipolytic protein G-D-S-L family
DI291_12000	COG1999	signal sequence binding
DI291_12020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DI291_12025	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DI291_12030	COG1272	protein, Hemolysin III
DI291_12035	COG0204	Acyl-transferase
DI291_12040	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DI291_12050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DI291_12060	COG2521	methyltransferase
DI291_12060	COG2136	Putative SAM-dependent methyltransferase
DI291_12070	COG0129	dihydroxy-acid dehydratase activity
DI291_12075	COG1413	lyase activity
DI291_12080	COG1418	mRNA catabolic process
DI291_12085	COG0386	Belongs to the glutathione peroxidase family
DI291_12090	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DI291_12095	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DI291_12100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_12110	COG1278	Cold shock
DI291_12130	COG0328	RNA-DNA hybrid ribonuclease activity
DI291_12135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DI291_12140	COG0328	RNA-DNA hybrid ribonuclease activity
DI291_12150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DI291_12160	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DI291_12170	COG1755	Isoprenylcysteine carboxyl methyltransferase
DI291_12175	COG3424	synthase
DI291_12185	COG2233	PERMEase
DI291_12190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DI291_12195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DI291_12200	COG1199	ATP-dependent helicase activity
DI291_12220	COG0116	Belongs to the methyltransferase superfamily
DI291_12230	COG3599	regulation of cell shape
DI291_12235	COG4474	Belongs to the UPF0398 family
DI291_12245	COG3359	exonuclease
DI291_12250	COG1111	helicase
DI291_12250	COG1205	dead DEAH box helicase
DI291_12255	COG2190	(PTS) system
DI291_12260	COG0071	Belongs to the small heat shock protein (HSP20) family
DI291_12295	COG3331	DNA recombination
DI291_12300	COG4499	WXG100 protein secretion system (Wss), protein YukC
DI291_12300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_12310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DI291_12315	COG3935	DnaD domain protein
DI291_12320	COG0017	Asparaginyl-tRNA synthetase
DI291_12325	COG0436	Aminotransferase
DI291_12330	COG5353	protein conserved in bacteria
DI291_12340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DI291_12340	COG1199	ATP-dependent helicase activity
DI291_12345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DI291_12350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DI291_12355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DI291_12370	COG0617	tRNA 3'-terminal CCA addition
DI291_12375	COG0438	transferase activity, transferring glycosyl groups
DI291_12380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DI291_12385	COG1803	Methylglyoxal synthase
DI291_12390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DI291_12395	COG1694	Mazg nucleotide pyrophosphohydrolase
DI291_12400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_12410	COG4347	Protein of unknown function (DUF1405)
DI291_12415	COG2010	Cytochrome c
DI291_12415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DI291_12420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DI291_12425	COG0723	plastoquinol--plastocyanin reductase activity
DI291_12435	COG5582	Belongs to the UPF0302 family
DI291_12440	COG0457	Tetratricopeptide repeat
DI291_12445	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DI291_12450	COG0287	Prephenate dehydrogenase
DI291_12455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DI291_12460	COG0159	tryptophan synthase activity
DI291_12465	COG0133	tryptophan synthase activity
DI291_12470	COG0135	phosphoribosylanthranilate isomerase activity
DI291_12475	COG0134	indole-3-glycerol-phosphate synthase activity
DI291_12480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DI291_12485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DI291_12490	COG4401	Chorismate mutase type I
DI291_12495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DI291_12500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DI291_12505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DI291_12510	COG0105	UTP biosynthetic process
DI291_12515	COG0142	geranyltranstransferase activity
DI291_12520	COG2226	methyltransferase
DI291_12525	COG0142	geranyltranstransferase activity
DI291_12540	COG0776	regulation of translation
DI291_12545	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DI291_12565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DI291_12570	COG1160	GTP binding
DI291_12595	COG1304	FMN binding
DI291_12600	COG0539	negative regulation of cytoplasmic translation
DI291_12605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DI291_12610	COG2959	enzyme of heme biosynthesis
DI291_12615	COG3409	Peptidoglycan-binding domain 1 protein
DI291_12615	COG3773	Cell wall hydrolase
DI291_12620	COG2339	peptidase activity
DI291_12630	COG0492	ferredoxin-NADP+ reductase activity
DI291_12635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DI291_12640	COG4862	establishment of competence for transformation
DI291_12645	COG1408	metallophosphoesterase
DI291_12655	COG1388	LysM domain
DI291_12660	COG1266	CAAX protease self-immunity
DI291_12665	COG0514	ATP-dependent DNA helicase (RecQ)
DI291_12670	COG4955	Helix-turn-helix domain
DI291_12675	COG1141	Ferredoxin
DI291_12680	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DI291_12685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DI291_12690	COG0739	heme binding
DI291_12700	COG1595	DNA-templated transcription, initiation
DI291_12705	COG1316	TRANSCRIPTIONal
DI291_12720	COG5002	protein histidine kinase activity
DI291_12725	COG0745	RESPONSE REGULATOR receiver
DI291_12730	COG5002	protein histidine kinase activity
DI291_12735	COG0745	RESPONSE REGULATOR receiver
DI291_12740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DI291_12745	COG1333	cytochrome c biogenesis protein
DI291_12750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_12755	COG1187	pseudouridine synthase activity
DI291_12760	COG0700	Nucleoside recognition
DI291_12765	COG2715	membrane protein required for spore maturation
DI291_12770	COG1686	Belongs to the peptidase S11 family
DI291_12780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DI291_12785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DI291_12795	COG1547	Domain of unknown function (DUF309)
DI291_12800	COG0456	acetyltransferase
DI291_12805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DI291_12810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DI291_12810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DI291_12815	COG0307	riboflavin synthase, alpha
DI291_12820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DI291_12820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DI291_12840	COG0457	Tetratricopeptide repeat
DI291_12845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DI291_12850	COG4086	secreted protein
DI291_12855	COG4195	phage-related replication protein
DI291_12865	COG0019	diaminopimelate decarboxylase activity
DI291_12875	COG0697	spore germination
DI291_12890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DI291_12925	COG1686	Belongs to the peptidase S11 family
DI291_12930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DI291_12935	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DI291_12940	COG4974	Belongs to the 'phage' integrase family
DI291_12950	COG0735	belongs to the Fur family
DI291_12955	COG1300	Membrane
DI291_12960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_12970	COG1953	Uracil, thiamine, allantoin
DI291_12985	COG2153	protein acetylation
DI291_12990	COG1379	DNA repair
DI291_12995	COG0494	nUDIX hydrolase
DI291_13005	COG1309	transcriptional regulator
DI291_13015	COG0667	Aldo Keto reductase
DI291_13025	COG1073	alpha beta
DI291_13035	COG4918	Iron-sulphur cluster biosynthesis
DI291_13045	COG0456	acetyltransferase
DI291_13045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DI291_13050	COG2329	Antibiotic biosynthesis monooxygenase
DI291_13055	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DI291_13065	COG0747	negative chemotaxis
DI291_13070	COG0601	transmembrane transport
DI291_13075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_13080	COG0444	Belongs to the ABC transporter superfamily
DI291_13090	COG0534	Mate efflux family protein
DI291_13105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DI291_13115	COG2211	Major facilitator Superfamily
DI291_13120	COG0346	lactoylglutathione lyase activity
DI291_13125	COG1072	(Pantothenic acid kinase))
DI291_13140	COG3842	ATPase activity
DI291_13165	COG2205	protein histidine kinase activity
DI291_13170	COG0745	RESPONSE REGULATOR receiver
DI291_13190	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DI291_13195	COG2814	Major facilitator Superfamily
DI291_13205	COG4195	phage-related replication protein
DI291_13235	COG0300	oxidoreductase activity
DI291_13240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_13245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DI291_13250	COG4187	Peptidase family M20/M25/M40
DI291_13255	COG1902	pentaerythritol trinitrate reductase activity
DI291_13260	COG0596	Alpha beta hydrolase
DI291_13265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DI291_13270	COG1234	tRNA 3'-trailer cleavage
DI291_13275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DI291_13290	COG2358	TRAP transporter, solute receptor (TAXI family
DI291_13295	COG2188	Transcriptional regulator
DI291_13300	COG2723	6-phospho-beta-galactosidase activity
DI291_13305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_13310	COG1447	Phosphotransferase system cellobiose-specific component IIA
DI291_13315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_13320	COG1785	Belongs to the alkaline phosphatase family
DI291_13325	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_13330	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DI291_13335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DI291_13345	COG0706	membrane insertase activity
DI291_13350	COG2195	Cleaves the N-terminal amino acid of tripeptides
DI291_13355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DI291_13360	COG4129	membrane
DI291_13365	COG1126	abc transporter atp-binding protein
DI291_13370	COG0765	amino acid transport
DI291_13375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DI291_13385	COG1597	lipid kinase activity
DI291_13390	COG0508	dehydrogenase complex catalyzes the overall conversion of
DI291_13395	COG0022	dehydrogenase e1 component
DI291_13400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DI291_13405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DI291_13410	COG3426	butyrate kinase activity
DI291_13420	COG0280	phosphate acetyltransferase
DI291_13425	COG3829	transcription factor binding
DI291_13425	COG3290	protein histidine kinase activity
DI291_13435	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_13440	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_13465	COG0745	RESPONSE REGULATOR receiver
DI291_13470	COG0750	zinc metalloprotease
DI291_13475	COG0497	DNA recombination
DI291_13480	COG1438	arginine binding
DI291_13485	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DI291_13490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DI291_13495	COG0142	geranyltranstransferase activity
DI291_13500	COG1722	exodeoxyribonuclease VII activity
DI291_13505	COG1570	exodeoxyribonuclease VII activity
DI291_13510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DI291_13515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DI291_13520	COG1302	Protein conserved in bacteria
DI291_13525	COG0439	Biotin carboxylase
DI291_13530	COG0511	ligase activity, forming carbon-carbon bonds
DI291_13570	COG3854	ATPases associated with a variety of cellular activities
DI291_13580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DI291_13585	COG0006	proline dipeptidase activity
DI291_13590	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DI291_13600	COG3872	metal-dependent enzyme
DI291_13610	COG1752	Esterase of the alpha-beta hydrolase superfamily
DI291_13615	COG1321	iron dependent repressor
DI291_13620	COG0095	Lipoate-protein ligase
DI291_13625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_13630	COG2113	Glycine betaine
DI291_13635	COG4176	ABC-type proline glycine betaine transport system permease component
DI291_13640	COG0517	IMP dehydrogenase activity
DI291_13640	COG4175	Glycine betaine
DI291_13645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DI291_13650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DI291_13655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DI291_13665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DI291_13690	COG0681	Belongs to the peptidase S26 family
DI291_13715	COG4940	Competence protein ComGF
DI291_13725	COG4970	Tfp pilus assembly protein FimT
DI291_13730	COG4537	Required for transformation and DNA binding
DI291_13735	COG1459	type II secretion system
DI291_13740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DI291_13745	COG1366	Belongs to the anti-sigma-factor antagonist family
DI291_13755	COG1393	Belongs to the ArsC family
DI291_13765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_13775	COG0011	TIGRFAM Protein of
DI291_13785	COG2866	Carboxypeptidase
DI291_13790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_13795	COG1368	sulfuric ester hydrolase activity
DI291_13800	COG1940	carbohydrate kinase activity
DI291_13805	COG4483	Protein conserved in bacteria
DI291_13810	COG0697	spore germination
DI291_13815	COG0705	Rhomboid family
DI291_13815	COG0457	Tetratricopeptide repeat
DI291_13820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DI291_13825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DI291_13830	COG0438	transferase activity, transferring glycosyl groups
DI291_13845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DI291_13895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DI291_13900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DI291_13905	COG0581	inorganic phosphate transmembrane transporter activity
DI291_13910	COG0573	inorganic phosphate transmembrane transporter activity
DI291_13915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DI291_13920	COG0768	penicillin binding
DI291_13925	COG0477	Major facilitator Superfamily
DI291_13935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DI291_13940	COG2839	Protein conserved in bacteria
DI291_13945	COG5521	maltodextrose utilization protein MalA
DI291_13950	COG1388	LysM domain
DI291_13955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DI291_13960	COG4709	membrane
DI291_13965	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DI291_13970	COG0735	belongs to the Fur family
DI291_13975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DI291_13980	COG1121	(ABC) transporter
DI291_13985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_13995	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DI291_14000	COG0513	Belongs to the DEAD box helicase family
DI291_14010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DI291_14015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DI291_14020	COG2384	SAM-dependent methyltransferase
DI291_14060	COG5444	nuclease activity
DI291_14075	COG2010	Cytochrome c
DI291_14080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DI291_14085	COG0358	DNA primase activity
DI291_14090	COG1671	Belongs to the UPF0178 family
DI291_14095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DI291_14100	COG0517	IMP dehydrogenase activity
DI291_14105	COG0751	glycine-tRNA ligase activity
DI291_14110	COG0752	glycyl-tRNA synthetase alpha subunit
DI291_14115	COG1381	Involved in DNA repair and RecF pathway recombination
DI291_14125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DI291_14130	COG0295	cytidine deaminase activity
DI291_14135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DI291_14140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DI291_14145	COG1480	7TM receptor with intracellular HD hydrolase
DI291_14150	COG1702	phosphate starvation-inducible protein PhoH
DI291_14155	COG0561	phosphatase activity
DI291_14170	COG4864	UPF0365 protein
DI291_14175	COG1030	water channel activity
DI291_14180	COG1610	YqeY-like protein
DI291_14185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DI291_14190	COG1283	sodium-dependent phosphate transmembrane transporter activity
DI291_14195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DI291_14200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DI291_14205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DI291_14210	COG2264	protein methyltransferase activity
DI291_14215	COG0484	heat shock protein binding
DI291_14220	COG0443	Heat shock 70 kDa protein
DI291_14225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DI291_14230	COG1420	regulation of RNA biosynthetic process
DI291_14235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DI291_14240	COG0481	GTPase activity
DI291_14250	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_14255	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DI291_14260	COG0268	Binds directly to 16S ribosomal RNA
DI291_14275	COG1733	regulation of RNA biosynthetic process
DI291_14280	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_14285	COG1466	dna polymerase III delta subunit
DI291_14295	COG2333	competence protein COMEC
DI291_14295	COG0658	competence protein
DI291_14300	COG2131	deaminase
DI291_14305	COG1555	photosystem II stabilization
DI291_14305	COG1596	polysaccharide export
DI291_14310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DI291_14315	COG2226	methyltransferase
DI291_14320	COG0799	negative regulation of ribosome biogenesis
DI291_14325	COG1713	HD superfamily hydrolase involved in NAD metabolism
DI291_14330	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DI291_14335	COG1534	Rna-binding protein
DI291_14340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DI291_14345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DI291_14350	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DI291_14360	COG2755	lipolytic protein G-D-S-L family
DI291_14370	COG5609	conserved protein (DUF2294)
DI291_14375	COG3383	formate dehydrogenase (NAD+) activity
DI291_14380	COG2427	Protein of unknown function (DUF1641)
DI291_14425	COG3223	Belongs to the PsiE family
DI291_14430	COG5002	protein histidine kinase activity
DI291_14430	COG0642	Histidine kinase
DI291_14435	COG0745	RESPONSE REGULATOR receiver
DI291_14440	COG2311	Membrane
DI291_14445	COG0454	-acetyltransferase
DI291_14465	COG3616	Alanine racemase, N-terminal domain
DI291_14470	COG0251	oxidation-reduction process
DI291_14480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_14485	COG0251	oxidation-reduction process
DI291_14505	COG1486	melibiose metabolic process
DI291_14530	COG0789	Transcriptional regulator
DI291_14530	COG4978	Transcriptional regulator
DI291_14560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_14570	COG2197	response regulator
DI291_14575	COG4585	Histidine kinase
DI291_14580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_14585	COG0730	response to heat
DI291_14590	COG0425	Belongs to the sulfur carrier protein TusA family
DI291_14595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_14595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_14600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_14600	COG0425	Belongs to the sulfur carrier protein TusA family
DI291_14605	COG2210	Belongs to the sulfur carrier protein TusA family
DI291_14610	COG1937	Protein conserved in bacteria
DI291_14625	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DI291_14630	COG1522	sequence-specific DNA binding
DI291_14665	COG1942	4-Oxalocrotonate Tautomerase
DI291_14670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DI291_14675	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DI291_14680	COG1733	regulation of RNA biosynthetic process
DI291_14685	COG3239	Fatty acid desaturase
DI291_14690	COG4585	Histidine kinase
DI291_14695	COG2197	response regulator
DI291_14700	COG0492	ferredoxin-NADP+ reductase activity
DI291_14705	COG0747	negative chemotaxis
DI291_14710	COG0601	transmembrane transport
DI291_14715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DI291_14720	COG0444	Belongs to the ABC transporter superfamily
DI291_14725	COG4608	Belongs to the ABC transporter superfamily
DI291_14745	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_14760	COG2124	cytochrome p450
DI291_14770	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_14775	COG2211	Major facilitator Superfamily
DI291_14785	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_14790	COG1621	beta-fructofuranosidase activity
DI291_14795	COG3716	PTS system mannose fructose sorbose family IID component
DI291_14800	COG3715	PTS system
DI291_14805	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_14810	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_14815	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DI291_14815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DI291_14835	COG2169	Transcriptional regulator
DI291_14840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DI291_14845	COG2205	protein histidine kinase activity
DI291_14855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DI291_14860	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DI291_14870	COG0656	L-ascorbic acid biosynthetic process
DI291_14875	COG2814	Major facilitator Superfamily
DI291_14880	COG1733	regulation of RNA biosynthetic process
DI291_14885	COG3340	Belongs to the peptidase S51 family
DI291_14890	COG1587	Uroporphyrinogen-III synthase
DI291_14900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_14905	COG0583	DNA-binding transcription factor activity
DI291_14910	COG2814	Major facilitator Superfamily
DI291_14920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DI291_14920	COG2124	cytochrome p450
DI291_14925	COG1309	transcriptional regulator
DI291_14930	COG1404	Belongs to the peptidase S8 family
DI291_14935	COG2226	methyltransferase
DI291_14955	COG0626	cystathionine gamma-synthase activity
DI291_14960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_14965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DI291_14970	COG2226	methyltransferase
DI291_14985	COG0768	penicillin binding
DI291_14990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DI291_14995	COG0572	uridine kinase
DI291_15000	COG0826	peptidase U32
DI291_15005	COG0826	peptidase U32
DI291_15010	COG4122	O-methyltransferase activity
DI291_15015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DI291_15020	COG3906	Belongs to the UPF0473 family
DI291_15025	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DI291_15030	COG4472	Bacterial protein of unknown function (DUF965)
DI291_15035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DI291_15040	COG0628	permease
DI291_15055	COG3881	PFAM PRC-barrel domain
DI291_15060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DI291_15065	COG0457	Tetratricopeptide repeat
DI291_15070	COG0482	sulfurtransferase activity
DI291_15075	COG1104	cysteine desulfurase activity
DI291_15080	COG1959	2 iron, 2 sulfur cluster binding
DI291_15085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DI291_15090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DI291_15100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DI291_15105	COG0124	histidyl-tRNA synthetase
DI291_15110	COG0860	N-Acetylmuramoyl-L-alanine amidase
DI291_15110	COG3103	Sh3 type 3 domain protein
DI291_15110	COG4991	sh3 domain protein
DI291_15115	COG1490	D-aminoacyl-tRNA deacylase activity
DI291_15120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DI291_15125	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DI291_15130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DI291_15130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DI291_15135	COG5416	Lipopolysaccharide assembly protein A domain
DI291_15140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DI291_15140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DI291_15150	COG2244	polysaccharide biosynthetic process
DI291_15155	COG2323	membrane
DI291_15165	COG1862	Preprotein translocase
DI291_15170	COG0343	queuine tRNA-ribosyltransferase activity
DI291_15175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DI291_15185	COG2255	four-way junction helicase activity
DI291_15190	COG0632	four-way junction helicase activity
DI291_15200	COG2112	serine threonine protein kinase
DI291_15210	COG2318	DinB family
DI291_15215	COG4195	phage-related replication protein
DI291_15230	COG0217	transcriptional regulatory protein
DI291_15240	COG1388	LysM domain
DI291_15245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DI291_15250	COG0157	Belongs to the NadC ModD family
DI291_15255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DI291_15260	COG1104	cysteine desulfurase activity
DI291_15265	COG1827	regulation of RNA biosynthetic process
DI291_15270	COG0077	Prephenate dehydratase
DI291_15275	COG4492	Belongs to the UPF0735 family
DI291_15280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DI291_15285	COG3290	protein histidine kinase activity
DI291_15290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DI291_15295	COG2868	ribosomal protein
DI291_15300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DI291_15305	COG1994	Peptidase M50
DI291_15310	COG0739	heme binding
DI291_15315	COG3832	glyoxalase III activity
DI291_15320	COG0640	Transcriptional regulator
DI291_15325	COG2894	cell division
DI291_15330	COG0850	regulation of cytokinetic process
DI291_15335	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DI291_15345	COG1077	Cell shape determining protein MreB Mrl
DI291_15350	COG2003	Belongs to the UPF0758 family
DI291_15355	COG0424	maF-like protein
DI291_15365	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DI291_15370	COG0285	dihydrofolate synthase activity
DI291_15375	COG0525	valine-tRNA ligase activity
DI291_15385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DI291_15390	COG1388	LysM domain
DI291_15395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DI291_15400	COG0113	porphobilinogen synthase activity
DI291_15405	COG1587	Uroporphyrinogen-III synthase
DI291_15410	COG0181	hydroxymethylbilane synthase activity
DI291_15415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DI291_15420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DI291_15430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DI291_15435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DI291_15440	COG1067	ATP-dependent peptidase activity
DI291_15440	COG0470	DNA polymerase III
DI291_15445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DI291_15450	COG0544	peptidyl-prolyl cis-trans isomerase activity
DI291_15455	COG1477	protein flavinylation
DI291_15455	COG0457	Tetratricopeptide repeat
DI291_15460	COG0066	3-isopropylmalate dehydratase activity
DI291_15465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DI291_15470	COG0473	3-isopropylmalate dehydrogenase activity
DI291_15475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DI291_15480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DI291_15485	COG0440	acetolactate synthase activity
DI291_15490	COG0028	Belongs to the TPP enzyme family
DI291_15495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DI291_15505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DI291_15525	COG0622	Phosphoesterase
DI291_15530	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DI291_15535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DI291_15540	COG5401	PFAM Sporulation and spore germination
DI291_15545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DI291_15550	COG1846	Transcriptional regulator
DI291_15555	COG2197	response regulator
DI291_15560	COG4221	oxidoreductase activity
DI291_15565	COG0824	Thioesterase
DI291_15570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DI291_15575	COG1053	succinate dehydrogenase
DI291_15580	COG2009	succinate dehydrogenase
DI291_15585	COG1719	4-vinyl reductase, 4VR
DI291_15610	COG0527	aspartate kinase activity
DI291_15615	COG0322	excinuclease ABC activity
DI291_15620	COG3118	belongs to the thioredoxin family
DI291_15630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DI291_15635	COG2086	electron transfer activity
DI291_15640	COG1024	Enoyl-CoA hydratase
DI291_15645	COG1309	transcriptional regulator
DI291_15650	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_15655	COG3766	membrane
DI291_15660	COG1193	negative regulation of DNA recombination
DI291_15665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DI291_15665	COG1796	DNA polymerase
DI291_15670	COG1286	toxin biosynthetic process
DI291_15675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DI291_15680	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DI291_15695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_15695	COG0072	phenylalanine-tRNA ligase activity
DI291_15700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DI291_15705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DI291_15715	COG1966	Carbon starvation protein
DI291_15720	COG1309	transcriptional regulator
DI291_15725	COG3402	PFAM membrane-flanked domain
DI291_15740	COG3534	alpha-L-arabinofuranosidase
DI291_15745	COG0395	ABC-type sugar transport system, permease component
DI291_15750	COG1175	transmembrane transport
DI291_15755	COG1653	transport
DI291_15760	COG0371	Dehydrogenase
DI291_15765	COG0235	Class ii aldolase
DI291_15770	COG1069	ribulokinase activity
DI291_15775	COG2160	L-arabinose isomerase activity
DI291_15780	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_15785	COG1363	Peptidase, m42
DI291_15795	COG3326	Membrane
DI291_15800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DI291_15805	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DI291_15810	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DI291_15815	COG1346	cytolysis
DI291_15825	COG3540	Alkaline phosphatase
DI291_15830	COG3279	Response regulator of the LytR AlgR family
DI291_15835	COG3275	phosphorelay sensor kinase activity
DI291_15845	COG1011	Hydrolase
DI291_15850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DI291_15860	COG0398	Pfam SNARE associated Golgi protein
DI291_15865	COG1484	DNA-dependent DNA replication
DI291_15870	COG3611	Membrane attachment protein
DI291_15875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DI291_15890	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DI291_15895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DI291_15900	COG3866	Pectate lyase
DI291_15905	COG0237	dephospho-CoA kinase activity
DI291_15910	COG1971	Probably functions as a manganese efflux pump
DI291_15915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DI291_15920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DI291_15920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DI291_15925	COG5002	protein histidine kinase activity
DI291_15930	COG0745	RESPONSE REGULATOR receiver
DI291_15935	COG0039	L-malate dehydrogenase activity
DI291_15940	COG0538	isocitrate dehydrogenase activity
DI291_15945	COG0372	Belongs to the citrate synthase family
DI291_15955	COG2273	Hydrolase Family 16
DI291_15960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DI291_15965	COG2707	UPF0756 membrane protein
DI291_15970	COG0628	permease
DI291_15975	COG3030	protein affecting phage T7 exclusion by the F plasmid
DI291_15985	COG0205	6-phosphofructokinase activity
DI291_15990	COG0825	malonyl-CoA metabolic process
DI291_15995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DI291_16000	COG0281	malic enzyme
DI291_16005	COG0587	DNA-directed DNA polymerase activity
DI291_16025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DI291_16035	COG4109	DRTGG domain
DI291_16040	COG1695	Transcriptional regulator
DI291_16045	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DI291_16050	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_16055	COG0165	Argininosuccinate lyase
DI291_16060	COG0137	argininosuccinate synthase activity
DI291_16065	COG0521	Mo-molybdopterin cofactor biosynthetic process
DI291_16070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DI291_16075	COG0827	DNA restriction-modification system
DI291_16080	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DI291_16085	COG3874	Sporulation protein YtfJ
DI291_16095	COG1714	RDD family
DI291_16100	COG0616	signal peptide processing
DI291_16105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DI291_16110	COG1846	Transcriptional regulator
DI291_16115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI291_16125	COG0301	tRNA thio-modification
DI291_16130	COG1104	cysteine desulfurase activity
DI291_16135	COG1114	Component of the transport system for branched-chain amino acids
DI291_16140	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DI291_16145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DI291_16150	COG1309	transcriptional regulator
DI291_16155	COG1956	GAF domain-containing protein
DI291_16160	COG2199	diguanylate cyclase activity
DI291_16160	COG2203	Gaf domain
DI291_16165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DI291_16180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DI291_16185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DI291_16190	COG0454	-acetyltransferase
DI291_16195	COG0517	IMP dehydrogenase activity
DI291_16200	COG0123	including yeast histone deacetylase and acetoin utilization protein
DI291_16205	COG1360	Flagellar Motor Protein
DI291_16210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DI291_16215	COG1609	Transcriptional regulator
DI291_16220	COG1605	Chorismate mutase
DI291_16220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DI291_16230	COG3118	belongs to the thioredoxin family
DI291_16235	COG4980	gas vesicle protein
DI291_16240	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DI291_16245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DI291_16250	COG1674	ftsk spoiiie
DI291_16255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DI291_16260	COG4848	Belongs to the UPF0354 family
DI291_16265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_16275	COG1363	Peptidase, m42
DI291_16280	COG5584	Small secreted protein
DI291_16285	COG0281	malic enzyme
DI291_16290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DI291_16295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DI291_16305	COG0510	thiamine kinase activity
DI291_16310	COG1523	belongs to the glycosyl hydrolase 13 family
DI291_16315	COG1597	lipid kinase activity
DI291_16325	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DI291_16330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DI291_16345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DI291_16350	COG2252	PERMEase
DI291_16355	COG4473	ABC transporter
DI291_16360	COG1131	(ABC) transporter
DI291_16365	COG1349	DNA-binding transcription factor activity
DI291_16370	COG1187	pseudouridine synthase activity
DI291_16375	COG2244	polysaccharide biosynthetic process
DI291_16380	COG2081	HI0933 family
DI291_16385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DI291_16400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_16415	COG5578	integral membrane protein
DI291_16420	COG0673	inositol 2-dehydrogenase activity
DI291_16425	COG1653	transport
DI291_16430	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DI291_16435	COG4209	transmembrane transport
DI291_16440	COG2207	Transcriptional regulator
DI291_16445	COG1653	transport
DI291_16450	COG0395	ABC-type sugar transport system, permease component
DI291_16455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI291_16460	COG1073	alpha beta
DI291_16470	COG0583	DNA-binding transcription factor activity
DI291_16475	COG0346	lactoylglutathione lyase activity
DI291_16480	COG0495	leucyl-tRNA aminoacylation
DI291_16490	COG2814	Major facilitator Superfamily
DI291_16495	COG1464	Belongs to the NlpA lipoprotein family
DI291_16500	COG2433	Pfam Transposase IS66
DI291_16505	COG0577	efflux transmembrane transporter activity
DI291_16510	COG1136	(ABC) transporter
DI291_16520	COG1131	(ABC) transporter
DI291_16525	COG1725	Transcriptional regulator
DI291_16535	COG1242	4 iron, 4 sulfur cluster binding
DI291_16540	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DI291_16545	COG1301	dicarboxylic acid transport
DI291_16555	COG2267	carboxylic ester hydrolase activity
DI291_16560	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DI291_16565	COG0671	phosphoesterase, PA-phosphatase related
DI291_16570	COG0438	transferase activity, transferring glycosyl groups
DI291_16570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_16575	COG0367	asparagine synthase
DI291_16580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DI291_16585	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DI291_16600	COG1506	peptidase
DI291_16605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DI291_16610	COG1116	anion transmembrane transporter activity
DI291_16615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DI291_16620	COG0494	nUDIX hydrolase
DI291_16630	COG4824	toxin secretion phage lysis holin
DI291_16635	COG0783	Belongs to the Dps family
DI291_16650	COG1854	S-ribosylhomocysteine lyase activity
DI291_16655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DI291_16660	COG0288	reversible hydration of carbon dioxide
DI291_16665	COG0523	cobalamin synthesis protein
DI291_16670	COG0803	Belongs to the bacterial solute-binding protein 9 family
DI291_16675	COG0254	rRNA binding
DI291_16680	COG1271	oxidase subunit
DI291_16685	COG1294	oxidase, subunit
DI291_16700	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_16705	COG0318	PFAM AMP-dependent synthetase and ligase
DI291_16710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DI291_16715	COG0596	Alpha beta hydrolase
DI291_16720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DI291_16725	COG1169	isochorismate synthase
DI291_16730	COG1575	Belongs to the MenA family. Type 1 subfamily
DI291_16735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DI291_16740	COG0058	SHG alpha-glucan phosphorylase activity
DI291_16745	COG0297	glycogen (starch) synthase activity
DI291_16750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DI291_16755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DI291_16760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DI291_16885	COG1609	Transcriptional regulator
DI291_16890	COG3859	Proton-coupled thiamine transporter YuaJ
DI291_16895	COG3764	Sortase (surface protein transpeptidase)
DI291_16910	COG0457	Tetratricopeptide repeat
DI291_16915	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DI291_16920	COG0569	domain protein
DI291_16925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DI291_16935	COG2318	DinB family
DI291_16945	COG1454	alcohol dehydrogenase
DI291_16950	COG1012	belongs to the aldehyde dehydrogenase family
DI291_16955	COG1510	regulation of RNA biosynthetic process
DI291_16965	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DI291_16970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DI291_16975	COG2140	Oxalate decarboxylase
DI291_16985	COG1397	ADP-ribosylglycohydrolase
DI291_17040	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DI291_17050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DI291_17055	COG0726	polysaccharide deacetylase
DI291_17060	COG1408	metallophosphoesterase
DI291_17065	COG1968	undecaprenyl-diphosphatase activity
DI291_17070	COG0628	permease
DI291_17075	COG0673	inositol 2-dehydrogenase activity
DI291_17080	COG0693	protein deglycase activity
DI291_17085	COG0840	transmembrane signaling receptor activity
DI291_17090	COG0840	transmembrane signaling receptor activity
DI291_17095	COG0840	transmembrane signaling receptor activity
DI291_17105	COG2070	2-Nitropropane dioxygenase
DI291_17110	COG0432	Pfam Uncharacterised protein family UPF0047
DI291_17115	COG0366	Alpha amylase catalytic
DI291_17130	COG5297	Belongs to the glycosyl hydrolase family 6
DI291_17135	COG1253	flavin adenine dinucleotide binding
DI291_17140	COG2738	Putative neutral zinc metallopeptidase
DI291_17155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DI291_17165	COG2323	membrane
DI291_17170	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DI291_17200	COG5444	nuclease activity
DI291_17440	COG0166	Belongs to the GPI family
DI291_17445	COG1979	alcohol dehydrogenase
DI291_17450	COG2155	Conserved Protein
DI291_17455	COG1098	S1 RNA binding domain
DI291_17460	COG0436	Aminotransferase
DI291_17465	COG1522	sequence-specific DNA binding
DI291_17470	COG2267	carboxylic ester hydrolase activity
DI291_17485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DI291_17500	COG5018	Exonuclease
DI291_17505	COG2814	Major facilitator Superfamily
DI291_17510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_17515	COG3011	Protein conserved in bacteria
DI291_17525	COG3290	protein histidine kinase activity
DI291_17530	COG4565	transcriptional regulatory protein
DI291_17540	COG1183	phosphatidylcholine synthase activity
DI291_17545	COG0586	Pfam SNARE associated Golgi protein
DI291_17550	COG0688	phosphatidylethanolamine metabolic process
DI291_17555	COG3493	citrate carrier protein
DI291_17565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DI291_17565	COG2111	Na H antiporter
DI291_17570	COG2111	Na H antiporter
DI291_17575	COG1006	Multisubunit Na H antiporter MnhC subunit
DI291_17580	COG0651	ATP synthesis coupled electron transport
DI291_17585	COG1863	multisubunit Na H antiporter MnhE subunit
DI291_17590	COG2212	antiporter activity
DI291_17595	COG1320	monovalent cation:proton antiporter activity
DI291_17600	COG2050	protein possibly involved in aromatic compounds catabolism
DI291_17605	COG2197	response regulator
DI291_17610	COG4585	Histidine kinase
DI291_17620	COG0142	geranyltranstransferase activity
DI291_17640	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DI291_17645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DI291_17650	COG1335	isochorismatase
DI291_17655	COG5506	Protein of unknown function (DUF1694)
DI291_17670	COG0628	permease
DI291_17675	COG1959	2 iron, 2 sulfur cluster binding
DI291_17680	COG0657	acetylesterase activity
DI291_17690	COG1418	mRNA catabolic process
DI291_17695	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_17710	COG1511	domain protein
DI291_17715	COG1674	ftsk spoiiie
DI291_17715	COG0433	COG0433 Predicted ATPase
DI291_17720	COG4499	WXG100 protein secretion system (Wss), protein YukC
DI291_17725	COG5417	Belongs to the EsaB family
DI291_17730	COG4842	Belongs to the WXG100 family
DI291_17735	COG1115	amino acid carrier protein
DI291_17740	COG2508	Transcriptional regulator
DI291_17740	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DI291_17745	COG0686	Belongs to the AlaDH PNT family
DI291_17755	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DI291_17760	COG1268	BioY protein
DI291_17765	COG2056	Na+-H+ antiporter family
DI291_17770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DI291_17775	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DI291_17780	COG3584	3D domain protein
DI291_17790	COG1252	NADH dehydrogenase
DI291_17795	COG0492	ferredoxin-NADP+ reductase activity
DI291_17810	COG0456	acetyltransferase
DI291_17815	COG0316	Belongs to the HesB IscA family
DI291_17820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DI291_17825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DI291_17830	COG4844	belongs to the
DI291_17835	COG1252	NADH dehydrogenase
DI291_17840	COG5646	InterPro IPR014922
DI291_17855	COG0457	Tetratricopeptide repeat
DI291_17860	COG3479	Phenolic acid decarboxylase
DI291_17870	COG4837	Protein of unknown function (DUF1462)
DI291_17875	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DI291_17880	COG1506	peptidase
DI291_17880	COG4946	Tricorn protease homolog
DI291_17880	COG0823	Involved in the tonB-independent uptake of proteins
DI291_17885	COG0083	homoserine kinase activity
DI291_17890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DI291_17895	COG0460	homoserine dehydrogenase
DI291_17900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_17905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DI291_17910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DI291_17915	COG0647	UMP catabolic process
DI291_17920	COG2445	Protein of unknown function DUF86
DI291_17925	COG4470	Protein conserved in bacteria
DI291_17940	COG0739	heme binding
DI291_17950	COG0733	neurotransmitter:sodium symporter activity
DI291_17960	COG3377	Domain of unknown function (DUF1805)
DI291_17965	COG0737	Belongs to the 5'-nucleotidase family
DI291_17970	COG0730	response to heat
DI291_17975	COG1801	Protein of unknown function DUF72
DI291_17985	COG3226	Transcriptional regulator
DI291_17990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DI291_17995	COG2508	Transcriptional regulator
DI291_18000	COG2814	Major facilitator Superfamily
DI291_18005	COG1288	antiporter activity
DI291_18010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DI291_18020	COG2356	endonuclease I
DI291_18030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DI291_18045	COG0457	Tetratricopeptide repeat
DI291_18055	COG0719	Fe-S assembly protein
DI291_18060	COG0822	iron-sulfur transferase activity
DI291_18065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DI291_18070	COG0719	Fe-S assembly protein
DI291_18075	COG0396	ATPase activity
DI291_18085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DI291_18090	COG1464	Belongs to the NlpA lipoprotein family
DI291_18095	COG2011	ABC-type metal ion transport system permease component
DI291_18100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DI291_18110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DI291_18115	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DI291_18125	COG0509	glycine decarboxylation via glycine cleavage system
DI291_18130	COG1393	Belongs to the ArsC family
DI291_18135	COG1960	acyl-CoA dehydrogenase activity
DI291_18140	COG0183	Belongs to the thiolase family
DI291_18145	COG1250	3-hydroxyacyl-CoA dehydrogenase
DI291_18145	COG1024	Enoyl-CoA hydratase
DI291_18160	COG5577	PFAM Coat F domain
DI291_18175	COG1120	ATPase activity
DI291_18180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_18185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_18190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_18205	COG1686	Belongs to the peptidase S11 family
DI291_18210	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_18215	COG0783	Belongs to the Dps family
DI291_18220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_18225	COG0745	RESPONSE REGULATOR receiver
DI291_18230	COG2770	Histidine kinase
DI291_18230	COG2205	protein histidine kinase activity
DI291_18235	COG1309	transcriptional regulator
DI291_18240	COG0114	fumarate hydratase activity
DI291_18250	COG0697	spore germination
DI291_18255	COG0814	amino acid
DI291_18270	COG2197	response regulator
DI291_18275	COG4585	Histidine kinase
DI291_18280	COG4758	membrane
DI291_18290	COG1842	Phage shock protein A
DI291_18295	COG4758	membrane
DI291_18300	COG4677	pectinesterase activity
DI291_18305	COG2096	Adenosyltransferase
DI291_18310	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_18330	COG1454	alcohol dehydrogenase
DI291_18335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DI291_18340	COG1120	ATPase activity
DI291_18345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_18350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_18355	COG1802	Transcriptional regulator
DI291_18360	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_18365	COG2258	MOSC domain
DI291_18370	COG0583	DNA-binding transcription factor activity
DI291_18380	COG2721	sulfolactate sulfo-lyase activity
DI291_18385	COG0246	Mannitol dehydrogenase
DI291_18390	COG1609	Transcriptional regulator
DI291_18395	COG2211	Major facilitator Superfamily
DI291_18400	COG1904	glucuronate isomerase
DI291_18405	COG2205	protein histidine kinase activity
DI291_18410	COG0745	RESPONSE REGULATOR receiver
DI291_18415	COG1120	ATPase activity
DI291_18420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_18425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_18430	COG0531	amino acid
DI291_18440	COG1988	membrane-bound metal-dependent
DI291_18445	COG1368	sulfuric ester hydrolase activity
DI291_18450	COG2814	Major facilitator Superfamily
DI291_18455	COG0656	L-ascorbic acid biosynthetic process
DI291_18460	COG1940	carbohydrate kinase activity
DI291_18465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DI291_18475	COG0596	Alpha beta hydrolase
DI291_18480	COG3973	AAA domain
DI291_18485	COG2860	membrane
DI291_18490	COG0456	acetyltransferase
DI291_18490	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DI291_18495	COG0456	acetyltransferase
DI291_18500	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DI291_18505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DI291_18510	COG2217	Heavy metal translocating P-type atpase
DI291_18515	COG1653	transport
DI291_18520	COG1175	transmembrane transport
DI291_18525	COG0395	ABC-type sugar transport system, permease component
DI291_18530	COG1501	Belongs to the glycosyl hydrolase 31 family
DI291_18535	COG1472	Belongs to the glycosyl hydrolase 3 family
DI291_18540	COG1121	(ABC) transporter
DI291_18545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DI291_18550	COG0803	Belongs to the bacterial solute-binding protein 9 family
DI291_18570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_18570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_18570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DI291_18575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_18585	COG2217	Heavy metal translocating P-type atpase
DI291_18590	COG2608	mercury ion transmembrane transporter activity
DI291_18595	COG1937	Protein conserved in bacteria
DI291_18600	COG0693	protein deglycase activity
DI291_18605	COG1349	DNA-binding transcription factor activity
DI291_18610	COG1070	Carbohydrate kinase
DI291_18615	COG4952	isomerase
DI291_18625	COG3347	Dehydrogenase
DI291_18625	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_18635	COG2814	Major facilitator Superfamily
DI291_18640	COG2814	Major facilitator Superfamily
DI291_18650	COG2124	cytochrome p450
DI291_18660	COG1846	Transcriptional regulator
DI291_18670	COG0673	inositol 2-dehydrogenase activity
DI291_18675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DI291_18680	COG1054	Belongs to the UPF0176 family
DI291_18690	COG1191	sigma factor activity
DI291_18700	COG2140	Oxalate decarboxylase
DI291_18720	COG5520	Belongs to the glycosyl hydrolase 30 family
DI291_18725	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_18740	COG5444	nuclease activity
DI291_18760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DI291_18765	COG0557	exoribonuclease II activity
DI291_18770	COG1647	Serine aminopeptidase, S33
DI291_18775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DI291_18780	COG2002	toxin-antitoxin pair type II binding
DI291_18785	COG1476	TRANSCRIPTIONal
DI291_18790	COG1396	sequence-specific DNA binding
DI291_18795	COG1396	sequence-specific DNA binding
DI291_18800	COG1174	glycine betaine transport
DI291_18805	COG1732	Glycine betaine
DI291_18810	COG1174	glycine betaine transport
DI291_18815	COG0517	IMP dehydrogenase activity
DI291_18815	COG1125	glycine betaine transport
DI291_18820	COG1510	regulation of RNA biosynthetic process
DI291_18825	COG2095	MarC family integral membrane protein
DI291_18830	COG3064	Membrane
DI291_18840	COG4640	response to antibiotic
DI291_18845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_18865	COG0693	protein deglycase activity
DI291_18870	COG0148	phosphopyruvate hydratase activity
DI291_18875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DI291_18880	COG0149	triose-phosphate isomerase activity
DI291_18885	COG0126	phosphoglycerate kinase activity
DI291_18895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DI291_18900	COG2390	Transcriptional regulator
DI291_18905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_18910	COG1113	amino acid transport
DI291_18930	COG1556	Lactate utilization protein
DI291_18935	COG1139	Iron-sulfur cluster binding protein
DI291_18940	COG0247	lactate metabolic process
DI291_18945	COG2186	Transcriptional regulator
DI291_18950	COG1620	l-lactate permease
DI291_18955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DI291_18965	COG5039	Polysaccharide pyruvyl transferase
DI291_18970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DI291_18975	COG0110	maltose O-acetyltransferase activity
DI291_18980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DI291_18985	COG2244	polysaccharide biosynthetic process
DI291_18990	COG1216	Glycosyl transferase, family 2
DI291_18995	COG5039	Polysaccharide pyruvyl transferase
DI291_19000	COG1216	Glycosyl transferase, family 2
DI291_19010	COG0438	transferase activity, transferring glycosyl groups
DI291_19015	COG1215	transferase activity, transferring glycosyl groups
DI291_19020	COG0438	transferase activity, transferring glycosyl groups
DI291_19025	COG1086	Polysaccharide biosynthesis protein
DI291_19030	COG0489	protein tyrosine kinase activity
DI291_19035	COG3944	biosynthesis protein
DI291_19040	COG1396	sequence-specific DNA binding
DI291_19045	COG2249	NAD(P)H dehydrogenase (quinone) activity
DI291_19050	COG2271	Major facilitator Superfamily
DI291_19060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DI291_19070	COG1454	alcohol dehydrogenase
DI291_19075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DI291_19085	COG1733	regulation of RNA biosynthetic process
DI291_19090	COG1902	pentaerythritol trinitrate reductase activity
DI291_19095	COG1621	beta-fructofuranosidase activity
DI291_19100	COG1621	beta-fructofuranosidase activity
DI291_19115	COG0740	serine-type endopeptidase activity
DI291_19120	COG1611	Belongs to the LOG family
DI291_19125	COG1694	Mazg nucleotide pyrophosphohydrolase
DI291_19130	COG1078	dGTPase activity
DI291_19135	COG0659	secondary active sulfate transmembrane transporter activity
DI291_19140	COG0288	reversible hydration of carbon dioxide
DI291_19145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_19150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DI291_19155	COG0640	Transcriptional regulator
DI291_19165	COG2732	(Barnase) inhibitor
DI291_19170	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DI291_19175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_19180	COG1481	regulation of sporulation
DI291_19185	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DI291_19190	COG1660	Displays ATPase and GTPase activities
DI291_19195	COG1051	belongs to the nudix hydrolase family
DI291_19205	COG0492	ferredoxin-NADP+ reductase activity
DI291_19210	COG0457	Tetratricopeptide repeat
DI291_19215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DI291_19220	COG0140	phosphoribosyl-ATP diphosphatase activity
DI291_19220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DI291_19225	COG0107	imidazoleglycerol-phosphate synthase activity
DI291_19230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DI291_19235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DI291_19240	COG0131	Imidazoleglycerol-phosphate dehydratase
DI291_19245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DI291_19250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DI291_19255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DI291_19260	COG4990	cell redox homeostasis
DI291_19265	COG5297	Belongs to the glycosyl hydrolase family 6
DI291_19270	COG0110	maltose O-acetyltransferase activity
DI291_19275	COG0546	phosphoglycolate phosphatase activity
DI291_19280	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DI291_19285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DI291_19290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DI291_19295	COG1846	Transcriptional regulator
DI291_19300	COG2814	Major facilitator Superfamily
DI291_19305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DI291_19310	COG1950	PFAM Membrane protein of
DI291_19315	COG1983	PspC domain protein
DI291_19320	COG3595	metallopeptidase activity
DI291_19340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DI291_19345	COG0556	nucleotide-excision repair
DI291_19350	COG4897	Protein conserved in bacteria
DI291_19360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_19370	COG3409	Peptidoglycan-binding domain 1 protein
DI291_19370	COG0793	Belongs to the peptidase S41A family
DI291_19375	COG0473	3-isopropylmalate dehydrogenase activity
DI291_19380	COG3883	PFAM NLP P60 protein
DI291_19380	COG0791	NLP P60 protein
DI291_19385	COG2177	Part of the ABC transporter FtsEX involved in
DI291_19390	COG2884	Cell division ATP-binding protein ftsE
DI291_19400	COG2010	Cytochrome c
DI291_19405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_19415	COG0653	protein targeting
DI291_19420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DI291_19435	COG1516	flagellar protein fliS
DI291_19440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DI291_19445	COG1334	flagellar protein FlaG
DI291_19455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DI291_19460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DI291_19465	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DI291_19475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DI291_19480	COG4786	Flagellar basal body rod
DI291_19480	COG1256	bacterial-type flagellum assembly
DI291_19485	COG3418	PFAM FlgN family protein
DI291_19490	COG2747	anti-sigma28 factor FlgM
DI291_19500	COG1040	competence protein
DI291_19510	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DI291_19515	COG1307	EDD domain protein, DegV family
DI291_19520	COG2197	response regulator
DI291_19525	COG4585	Histidine kinase
DI291_19530	COG1739	Uncharacterized protein family UPF0029
DI291_19535	COG1316	TRANSCRIPTIONal
DI291_19545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DI291_19550	COG0438	transferase activity, transferring glycosyl groups
DI291_19555	COG1215	transferase activity, transferring glycosyl groups
DI291_19560	COG3206	protein involved in exopolysaccharide biosynthesis
DI291_19565	COG3307	-O-antigen
DI291_19570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DI291_19575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DI291_19580	COG0297	glycogen (starch) synthase activity
DI291_19580	COG0438	transferase activity, transferring glycosyl groups
DI291_19585	COG2244	polysaccharide biosynthetic process
DI291_19695	COG1482	cell wall glycoprotein biosynthetic process
DI291_19715	COG0800	Aldolase
DI291_19720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_19725	COG1609	Transcriptional regulator
DI291_19730	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DI291_19735	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_19740	COG1063	alcohol dehydrogenase
DI291_19745	COG2814	Major facilitator Superfamily
DI291_19750	COG1316	TRANSCRIPTIONal
DI291_19755	COG0561	phosphatase activity
DI291_19760	COG0791	NLP P60 protein
DI291_19765	COG2843	Capsule synthesis protein
DI291_19775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DI291_19780	COG1609	Transcriptional regulator
DI291_19785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_19790	COG1869	D-ribose catabolic process
DI291_19795	COG1129	ABC transporter
DI291_19800	COG1172	Belongs to the binding-protein-dependent transport system permease family
DI291_19805	COG1879	ABC-type sugar transport system periplasmic component
DI291_19810	COG0583	DNA-binding transcription factor activity
DI291_19815	COG2226	methyltransferase
DI291_19820	COG3527	Alpha-acetolactate decarboxylase
DI291_19825	COG0028	Belongs to the TPP enzyme family
DI291_19830	COG0583	DNA-binding transcription factor activity
DI291_19835	COG0405	Gamma-glutamyltransferase
DI291_19840	COG1522	sequence-specific DNA binding
DI291_19845	COG2059	Chromate
DI291_19850	COG2059	Chromate
DI291_19855	COG4464	protein tyrosine phosphatase activity
DI291_19860	COG3944	biosynthesis protein
DI291_19870	COG4715	Zinc finger, swim domain protein
DI291_19875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DI291_19880	COG3878	Protein conserved in bacteria
DI291_19885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DI291_19900	COG0561	phosphatase activity
DI291_19905	COG1349	DNA-binding transcription factor activity
DI291_19915	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_19925	COG3732	PTS system glucitol sorbitol-specific
DI291_19945	COG0629	single-stranded DNA binding
DI291_19960	COG1970	mechanosensitive ion channel activity
DI291_19965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DI291_19970	COG4786	Flagellar basal body rod
DI291_19975	COG4786	Flagellar basal body rod
DI291_19980	COG1077	Cell shape determining protein MreB Mrl
DI291_19985	COG1609	Transcriptional regulator
DI291_19995	COG1846	Transcriptional regulator
DI291_20000	COG2814	Major facilitator Superfamily
DI291_20005	COG0671	phosphoesterase, PA-phosphatase related
DI291_20010	COG1227	inorganic diphosphatase activity
DI291_20015	COG3546	catalase activity
DI291_20020	COG3361	conserved protein (COG2071)
DI291_20035	COG0517	IMP dehydrogenase activity
DI291_20040	COG0598	Magnesium transport protein CorA
DI291_20045	COG1253	flavin adenine dinucleotide binding
DI291_20050	COG0004	ammonium transporteR
DI291_20055	COG0347	Belongs to the P(II) protein family
DI291_20065	COG0740	serine-type endopeptidase activity
DI291_20075	COG0739	heme binding
DI291_20080	COG1247	-acetyltransferase
DI291_20090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DI291_20095	COG0477	Major facilitator Superfamily
DI291_20100	COG3251	PFAM MbtH domain protein
DI291_20105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_20110	COG1535	isochorismatase
DI291_20110	COG3433	isochorismatase activity
DI291_20115	COG1021	2,3-dihydroxybenzoate-AMP ligase
DI291_20120	COG1169	isochorismate synthase
DI291_20125	COG1028	Short-chain dehydrogenase reductase Sdr
DI291_20130	COG2819	hydrolase of the alpha beta superfamily
DI291_20135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_20140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_20145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_20150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_20150	COG2207	Transcriptional regulator
DI291_20165	COG1959	2 iron, 2 sulfur cluster binding
DI291_20175	COG1994	Peptidase M50
DI291_20180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DI291_20185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DI291_20190	COG2223	nitrite transmembrane transporter activity
DI291_20195	COG3383	formate dehydrogenase (NAD+) activity
DI291_20200	COG2304	oxidoreductase activity
DI291_20205	COG2304	oxidoreductase activity
DI291_20210	COG2385	sporulation resulting in formation of a cellular spore
DI291_20215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DI291_20225	COG4836	Membrane
DI291_20230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DI291_20235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DI291_20240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DI291_20245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DI291_20250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DI291_20255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DI291_20265	COG0356	it plays a direct role in the translocation of protons across the membrane
DI291_20280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DI291_20285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DI291_20290	COG4475	Protein of unknown function (DUF436)
DI291_20295	COG0698	ribose 5-phosphate isomerase
DI291_20300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DI291_20305	COG1971	Probably functions as a manganese efflux pump
DI291_20310	COG0009	L-threonylcarbamoyladenylate synthase
DI291_20315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DI291_20325	COG0738	Major facilitator superfamily
DI291_20330	COG0673	inositol 2-dehydrogenase activity
DI291_20335	COG0561	phosphatase activity
DI291_20340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DI291_20345	COG1609	Transcriptional regulator
DI291_20355	COG2890	protein-(glutamine-N5) methyltransferase activity
DI291_20360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DI291_20365	COG0346	lactoylglutathione lyase activity
DI291_20370	COG0789	Transcriptional regulator
DI291_20375	COG0679	Auxin Efflux Carrier
DI291_20380	COG0281	malic enzyme
DI291_20385	COG1435	thymidine kinase activity
DI291_20390	COG0254	rRNA binding
DI291_20395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DI291_20400	COG1494	fructose-1,6-bisphosphatase
DI291_20405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DI291_20410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DI291_20415	COG0191	fructose-bisphosphate aldolase activity
DI291_20420	COG2204	response regulator
DI291_20425	COG4821	SIS domain
DI291_20430	COG0504	CTP synthase activity
DI291_20435	COG3343	RNA polymerase activity
DI291_20440	COG1960	acyl-CoA dehydrogenase activity
DI291_20445	COG1960	acyl-CoA dehydrogenase activity
DI291_20450	COG1250	3-hydroxyacyl-CoA dehydrogenase
DI291_20455	COG0183	Belongs to the thiolase family
DI291_20460	COG2181	nitrate reductase activity
DI291_20460	COG0247	lactate metabolic process
DI291_20465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DI291_20475	COG0018	arginyl-trna synthetase
DI291_20480	COG4506	Protein conserved in bacteria
DI291_20485	COG0010	Belongs to the arginase family
DI291_20490	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DI291_20495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DI291_20505	COG1994	Peptidase M50
DI291_20510	COG1942	4-Oxalocrotonate Tautomerase
DI291_20520	COG3465	dGTPase activity
DI291_20525	COG1078	dGTPase activity
DI291_20530	COG4844	belongs to the
DI291_20555	COG2814	Major facilitator Superfamily
DI291_20580	COG1414	Transcriptional regulator
DI291_20590	COG0280	phosphate acetyltransferase
DI291_20595	COG3253	May function as heme-dependent peroxidase
DI291_20610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DI291_20630	COG1131	(ABC) transporter
DI291_20645	COG2363	Small membrane protein
DI291_20650	COG2233	PERMEase
DI291_20660	COG1012	belongs to the aldehyde dehydrogenase family
DI291_20665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DI291_20670	COG1216	Glycosyl transferase, family 2
DI291_20675	COG0351	phosphomethylpyrimidine kinase
DI291_20685	COG1621	beta-fructofuranosidase activity
DI291_20690	COG1263	PTS System
DI291_20690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_20695	COG3711	transcriptional antiterminator
DI291_20705	COG1404	Belongs to the peptidase S8 family
DI291_20715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DI291_20720	COG0778	Nitroreductase
DI291_20725	COG1473	amidohydrolase
DI291_20730	COG0772	Belongs to the SEDS family
DI291_20735	COG0772	Belongs to the SEDS family
DI291_20740	COG3314	Sporulation integral membrane protein YlbJ
DI291_20760	COG0456	acetyltransferase
DI291_20795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DI291_20805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DI291_20810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DI291_20815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_20830	COG0655	NAD(P)H dehydrogenase (quinone) activity
DI291_20835	COG3162	membrane
DI291_20840	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_20845	COG1070	Carbohydrate kinase
DI291_20850	COG2115	Belongs to the xylose isomerase family
DI291_20855	COG1940	carbohydrate kinase activity
DI291_20860	COG0352	thiamine-phosphate diphosphorylase activity
DI291_20865	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DI291_20870	COG0583	DNA-binding transcription factor activity
DI291_20885	COG1380	Effector of murein hydrolase LrgA
DI291_20890	COG1346	cytolysis
DI291_20900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DI291_20905	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DI291_20910	COG0346	lactoylglutathione lyase activity
DI291_20915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DI291_20920	COG1442	glycosyl transferase family 8
DI291_20930	COG4585	Histidine kinase
DI291_20935	COG2197	response regulator
DI291_20940	COG2409	Drug exporters of the RND superfamily
DI291_20945	COG5522	Integral membrane protein (intg_mem_TP0381)
DI291_20950	COG2271	Major facilitator Superfamily
DI291_20955	COG4948	Mandelate Racemase Muconate Lactonizing
DI291_20960	COG0800	Aldolase
DI291_20965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_20975	COG2234	aminopeptidase activity
DI291_20980	COG0477	Major facilitator Superfamily
DI291_20990	COG2357	RelA SpoT domain protein
DI291_21005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DI291_21010	COG1696	Membrane protein involved in D-alanine export
DI291_21015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DI291_21020	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DI291_21025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DI291_21030	COG2814	Major facilitator Superfamily
DI291_21035	COG1486	melibiose metabolic process
DI291_21040	COG1447	Phosphotransferase system cellobiose-specific component IIA
DI291_21045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_21050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_21055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DI291_21055	COG3711	transcriptional antiterminator
DI291_21060	COG2094	Belongs to the DNA glycosylase MPG family
DI291_21070	COG0372	Belongs to the citrate synthase family
DI291_21075	COG2079	MmgE PrpD family protein
DI291_21080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DI291_21095	COG1132	(ABC) transporter
DI291_21100	COG2755	lipolytic protein G-D-S-L family
DI291_21115	COG2814	Major facilitator Superfamily
DI291_21120	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DI291_21125	COG1131	(ABC) transporter
DI291_21145	COG1595	DNA-templated transcription, initiation
DI291_21150	COG2814	Major facilitator Superfamily
DI291_21160	COG0753	catalase activity
DI291_21165	COG0753	catalase activity
DI291_21170	COG0735	belongs to the Fur family
DI291_21175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DI291_21185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DI291_21190	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DI291_21195	COG4988	ABC transporter
DI291_21200	COG1294	oxidase, subunit
DI291_21205	COG1271	oxidase subunit
DI291_21215	COG2116	formate transmembrane transporter activity
DI291_21225	COG0281	malic enzyme
DI291_21230	COG1757	Na H antiporter
DI291_21235	COG1027	Aspartate ammonia-lyase
DI291_21240	COG0252	asparaginase activity
DI291_21245	COG1396	sequence-specific DNA binding
DI291_21250	COG2706	6-phosphogluconolactonase activity
DI291_21255	COG0745	RESPONSE REGULATOR receiver
DI291_21260	COG2205	protein histidine kinase activity
DI291_21265	COG1136	(ABC) transporter
DI291_21270	COG0577	efflux transmembrane transporter activity
DI291_21275	COG5294	Protein conserved in bacteria
DI291_21290	COG0726	polysaccharide deacetylase
DI291_21295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DI291_21305	COG1215	transferase activity, transferring glycosyl groups
DI291_21310	COG3493	citrate carrier protein
DI291_21320	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_21335	COG1368	sulfuric ester hydrolase activity
DI291_21345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DI291_21365	COG2235	arginine
DI291_21370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DI291_21380	COG0549	Belongs to the carbamate kinase family
DI291_21390	COG2723	6-phospho-beta-galactosidase activity
DI291_21395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DI291_21405	COG1595	DNA-templated transcription, initiation
DI291_21415	COG2195	Cleaves the N-terminal amino acid of tripeptides
DI291_21430	COG2223	nitrite transmembrane transporter activity
DI291_21435	COG0395	ABC-type sugar transport system, permease component
DI291_21440	COG1175	transmembrane transport
DI291_21450	COG1609	Transcriptional regulator
DI291_21465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DI291_21470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DI291_21475	COG0463	Glycosyl transferase, family 2
DI291_21480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_21505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DI291_21510	COG0693	protein deglycase activity
DI291_21510	COG0753	catalase activity
DI291_21520	COG2723	6-phospho-beta-galactosidase activity
DI291_21525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_21525	COG1263	PTS System
DI291_21525	COG2190	(PTS) system
DI291_21530	COG3711	transcriptional antiterminator
DI291_21535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DI291_21540	COG1122	ATPase activity
DI291_21545	COG4721	ABC-type cobalt transport system, permease component
DI291_21550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DI291_21555	COG2224	Isocitrate lyase
DI291_21560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DI291_21570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DI291_21630	COG0577	efflux transmembrane transporter activity
DI291_21635	COG1136	(ABC) transporter
DI291_21640	COG2205	protein histidine kinase activity
DI291_21645	COG0745	RESPONSE REGULATOR receiver
DI291_21650	COG2723	6-phospho-beta-galactosidase activity
DI291_21655	COG1263	PTS System
DI291_21655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DI291_21655	COG2190	(PTS) system
DI291_21665	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DI291_21670	COG3507	Belongs to the glycosyl hydrolase 43 family
DI291_21675	COG0513	Belongs to the DEAD box helicase family
DI291_21710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DI291_21715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DI291_21720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DI291_21725	COG2390	Transcriptional regulator
DI291_21730	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DI291_21735	COG3706	GGDEF domain
DI291_21740	COG5298	Protein conserved in bacteria
DI291_21745	COG1215	transferase activity, transferring glycosyl groups
DI291_21755	COG3977	Valine--pyruvate aminotransferase
DI291_21770	COG1181	Belongs to the D-alanine--D-alanine ligase family
DI291_21780	COG0191	fructose-bisphosphate aldolase activity
DI291_21785	COG1082	Xylose isomerase domain protein TIM barrel
DI291_21790	COG1082	Xylose isomerase domain protein TIM barrel
DI291_21795	COG0673	inositol 2-dehydrogenase activity
DI291_21800	COG2814	Major facilitator Superfamily
DI291_21805	COG1082	Xylose isomerase domain protein TIM barrel
DI291_21810	COG3962	Belongs to the TPP enzyme family
DI291_21815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DI291_21820	COG3718	enzyme involved in inositol metabolism
DI291_21825	COG1012	belongs to the aldehyde dehydrogenase family
DI291_21830	COG1349	DNA-binding transcription factor activity
DI291_21835	COG0667	Aldo Keto reductase
DI291_21840	COG0584	glycerophosphoryl diester phosphodiesterase
DI291_21845	COG2271	Major facilitator Superfamily
DI291_21850	COG0326	Molecular chaperone. Has ATPase activity
DI291_21855	COG0488	(ABC) transporter
DI291_21860	COG0561	phosphatase activity
DI291_21880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_21910	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DI291_21915	COG0577	efflux transmembrane transporter activity
DI291_21920	COG1136	(ABC) transporter
DI291_21925	COG2205	protein histidine kinase activity
DI291_21930	COG0745	RESPONSE REGULATOR receiver
DI291_21940	COG0840	transmembrane signaling receptor activity
DI291_21940	COG5278	phosphoserine phosphatase activity
DI291_21945	COG1115	amino acid carrier protein
DI291_21950	COG0686	Belongs to the AlaDH PNT family
DI291_21955	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DI291_21960	COG1874	Beta-galactosidase
DI291_21965	COG3833	ABC-type maltose transport systems, permease component
DI291_21970	COG1175	transmembrane transport
DI291_21975	COG2182	Extracellular solute-binding protein
DI291_21980	COG1609	Transcriptional regulator
DI291_21990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DI291_21995	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DI291_22000	COG1940	carbohydrate kinase activity
DI291_22010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DI291_22040	COG1012	belongs to the aldehyde dehydrogenase family
DI291_22040	COG1454	alcohol dehydrogenase
DI291_22045	COG0450	alkyl hydroperoxide reductase
DI291_22050	COG3634	alkyl hydroperoxide reductase activity
DI291_22055	COG1113	amino acid transport
DI291_22075	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DI291_22090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DI291_22095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_22100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DI291_22110	COG1131	(ABC) transporter
DI291_22135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DI291_22150	COG0456	acetyltransferase
DI291_22165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DI291_22170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DI291_22175	COG4853	Protein conserved in bacteria
DI291_22180	COG4863	YycH protein
DI291_22185	COG5002	protein histidine kinase activity
DI291_22190	COG0745	RESPONSE REGULATOR receiver
DI291_22215	COG1051	belongs to the nudix hydrolase family
DI291_22220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DI291_22230	COG0305	Participates in initiation and elongation during chromosome replication
DI291_22245	COG3093	addiction module antidote protein HigA
DI291_22250	COG2807	transmembrane transport
DI291_22255	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DI291_22260	COG0363	glucosamine-6-phosphate deaminase activity