locus-tag	class	description
QR42_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
QR42_00010	COG0592	DNA-directed DNA polymerase activity
QR42_00015	COG2501	S4 domain
QR42_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
QR42_00030	COG0187	DNA topoisomerase II activity
QR42_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
QR42_00070	COG0516	GMP reductase activity
QR42_00070	COG0517	IMP dehydrogenase activity
QR42_00075	COG1686	Belongs to the peptidase S11 family
QR42_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QR42_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
QR42_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
QR42_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
QR42_00100	COG0840	transmembrane signaling receptor activity
QR42_00110	COG1428	Deoxynucleoside kinase
QR42_00115	COG1428	Deoxynucleoside kinase
QR42_00120	COG1388	LysM domain
QR42_00120	COG3858	chitin binding
QR42_00125	COG1335	isochorismatase
QR42_00130	COG0590	tRNA wobble adenosine to inosine editing
QR42_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
QR42_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
QR42_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
QR42_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
QR42_00195	COG3853	Toxic anion resistance protein (TelA)
QR42_00200	COG1982	Orn Lys Arg decarboxylase major
QR42_00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
QR42_00210	COG3870	Protein conserved in bacteria
QR42_00215	COG1728	Protein conserved in bacteria
QR42_00220	COG0470	DNA polymerase III
QR42_00225	COG1774	PSP1 C-terminal conserved region
QR42_00230	COG4467	Involved in initiation control of chromosome replication
QR42_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
QR42_00240	COG2827	Endonuclease containing a URI domain
QR42_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
QR42_00250	COG2002	toxin-antitoxin pair type II binding
QR42_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QR42_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QR42_00260	COG0084	hydrolase, TatD family'
QR42_00265	COG3583	domain protein
QR42_00265	COG3584	3D domain protein
QR42_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
QR42_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
QR42_00285	COG4466	Protein conserved in bacteria
QR42_00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
QR42_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
QR42_00305	COG0251	oxidation-reduction process
QR42_00310	COG2088	sporulation resulting in formation of a cellular spore
QR42_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
QR42_00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
QR42_00330	COG0193	aminoacyl-tRNA hydrolase activity
QR42_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
QR42_00345	COG2002	toxin-antitoxin pair type II binding
QR42_00350	COG2244	polysaccharide biosynthetic process
QR42_00355	COG3956	TIGRFAM MazG family protein
QR42_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
QR42_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
QR42_00380	COG1098	S1 RNA binding domain
QR42_00395	COG2208	phosphoserine phosphatase activity
QR42_00400	COG2304	oxidoreductase activity
QR42_00405	COG0515	serine threonine protein kinase
QR42_00410	COG0037	tRNA processing
QR42_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
QR42_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
QR42_00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
QR42_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
QR42_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
QR42_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
QR42_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
QR42_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QR42_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
QR42_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
QR42_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
QR42_00475	COG1396	sequence-specific DNA binding
QR42_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
QR42_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
QR42_00565	COG4463	regulation of RNA biosynthetic process
QR42_00570	COG3880	PFAM UvrB UvrC protein
QR42_00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
QR42_00580	COG0542	response to heat
QR42_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
QR42_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
QR42_00595	COG4956	integral membrane protein (PIN domain superfamily)
QR42_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
QR42_00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
QR42_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
QR42_00615	COG1045	serine acetyltransferase
QR42_00620	COG0215	cysteine-tRNA ligase activity
QR42_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
QR42_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
QR42_00635	COG3688	RNA-binding protein containing a PIN domain
QR42_00640	COG1595	DNA-templated transcription, initiation
QR42_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
QR42_00650	COG0250	Participates in transcription elongation, termination and antitermination
QR42_00655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
QR42_00660	COG0081	regulation of translation
QR42_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
QR42_00670	COG0222	ribosome binding
QR42_00675	COG2813	Specifically methylates the guanine in position
QR42_00680	COG0085	RNA polymerase activity
QR42_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
QR42_00690	COG1358	cellular component organization or biogenesis
QR42_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
QR42_00700	COG0049	tRNA binding
QR42_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
QR42_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
QR42_00715	COG0596	Alpha beta hydrolase
QR42_00720	COG0051	transcription antitermination factor activity, RNA binding
QR42_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
QR42_00730	COG0088	Forms part of the polypeptide exit tunnel
QR42_00735	COG0089	rRNA binding
QR42_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
QR42_00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
QR42_00750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
QR42_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
QR42_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
QR42_00765	COG0255	Belongs to the universal ribosomal protein uL29 family
QR42_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
QR42_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
QR42_00780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
QR42_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
QR42_00790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
QR42_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
QR42_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
QR42_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
QR42_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
QR42_00815	COG1841	ribosomal large subunit assembly
QR42_00820	COG0200	Binds to the 23S rRNA
QR42_00825	COG0201	protein transport
QR42_00830	COG0563	adenylate kinase activity
QR42_00835	COG0024	Methionine aminopeptidase
QR42_00840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
QR42_00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
QR42_00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
QR42_00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
QR42_00860	COG0202	RNA polymerase activity
QR42_00865	COG0203	ribosomal protein L17
QR42_00870	COG1122	ATPase activity
QR42_00875	COG1122	ATPase activity
QR42_00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
QR42_00885	COG0101	tRNA pseudouridine synthase activity
QR42_00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
QR42_00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
QR42_00900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QR42_00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
QR42_00930	COG0489	protein tyrosine kinase activity
QR42_00940	COG2194	sulfuric ester hydrolase activity
QR42_00945	COG0726	polysaccharide deacetylase
QR42_00975	COG0659	secondary active sulfate transmembrane transporter activity
QR42_00980	COG0385	Bile acid
QR42_00985	COG3876	Protein conserved in bacteria
QR42_00990	COG1472	Belongs to the glycosyl hydrolase 3 family
QR42_00995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
QR42_01000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_01000	COG1263	PTS System
QR42_01005	COG1737	Transcriptional regulator
QR42_01010	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
QR42_01045	COG1595	DNA-templated transcription, initiation
QR42_01050	COG5662	AntiSigma factor
QR42_01055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
QR42_01060	COG4856	YbbR-like protein
QR42_01065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
QR42_01070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
QR42_01090	COG1131	(ABC) transporter
QR42_01105	COG1131	(ABC) transporter
QR42_01115	COG1413	lyase activity
QR42_01130	COG2311	Membrane
QR42_01150	COG1476	TRANSCRIPTIONal
QR42_01160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
QR42_01165	COG1309	transcriptional regulator
QR42_01180	COG1113	amino acid transport
QR42_01185	COG0584	glycerophosphoryl diester phosphodiesterase
QR42_01190	COG2271	Major facilitator Superfamily
QR42_01200	COG1331	Highly conserved protein containing a thioredoxin domain
QR42_01205	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
QR42_01225	COG1937	Protein conserved in bacteria
QR42_01230	COG2210	Belongs to the sulfur carrier protein TusA family
QR42_01235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QR42_01240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QR42_01240	COG0425	Belongs to the sulfur carrier protein TusA family
QR42_01245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QR42_01245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QR42_01250	COG0425	Belongs to the sulfur carrier protein TusA family
QR42_01255	COG0730	response to heat
QR42_01260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
QR42_01265	COG2814	Major facilitator Superfamily
QR42_01275	COG1846	Transcriptional regulator
QR42_01285	COG1683	Conserved Protein
QR42_01315	COG0656	L-ascorbic acid biosynthetic process
QR42_01320	COG0371	Dehydrogenase
QR42_01330	COG0531	amino acid
QR42_01340	COG3711	transcriptional antiterminator
QR42_01345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_01345	COG2190	(PTS) system
QR42_01345	COG1263	PTS System
QR42_01350	COG2723	6-phospho-beta-galactosidase activity
QR42_01365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_01365	COG3711	transcriptional antiterminator
QR42_01375	COG0383	alpha-mannosidase activity
QR42_01380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_01385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_01390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_01390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_01395	COG1404	Belongs to the peptidase S8 family
QR42_01410	COG0833	amino acid
QR42_01415	COG2040	homocysteine
QR42_01420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QR42_01425	COG1695	Transcriptional regulator
QR42_01435	COG2814	Major facilitator Superfamily
QR42_01455	COG1404	Belongs to the peptidase S8 family
QR42_01465	COG1309	transcriptional regulator
QR42_01470	COG1917	Cupin 2, conserved barrel domain protein
QR42_01475	COG1063	alcohol dehydrogenase
QR42_01480	COG1846	Transcriptional regulator
QR42_01485	COG0318	PFAM AMP-dependent synthetase and ligase
QR42_01490	COG0531	amino acid
QR42_01500	COG0596	Alpha beta hydrolase
QR42_01505	COG1115	amino acid carrier protein
QR42_01510	COG2066	Belongs to the glutaminase family
QR42_01515	COG4191	Histidine kinase
QR42_01520	COG0784	Response regulator, receiver
QR42_01525	COG3012	SEC-C Motif Domain Protein
QR42_01525	COG1405	negative regulation of cell septum assembly
QR42_01535	COG2197	response regulator
QR42_01540	COG4585	Histidine kinase
QR42_01550	COG0667	Aldo Keto reductase
QR42_01555	COG3290	protein histidine kinase activity
QR42_01560	COG3279	Response regulator of the LytR AlgR family
QR42_01565	COG4555	ABC transporter
QR42_01570	COG1668	transmembrane transport
QR42_01590	COG3773	Cell wall hydrolase
QR42_01595	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_01605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QR42_01610	COG2310	stress, protein
QR42_01615	COG2310	stress, protein
QR42_01620	COG2310	stress, protein
QR42_01625	COG0861	Integral membrane protein TerC family
QR42_01655	COG3853	Toxic anion resistance protein (TelA)
QR42_01660	COG4175	Glycine betaine
QR42_01660	COG0517	IMP dehydrogenase activity
QR42_01665	COG4176	ABC-type proline glycine betaine transport system permease component
QR42_01670	COG2113	Glycine betaine
QR42_01685	COG1473	amidohydrolase
QR42_01690	COG1288	antiporter activity
QR42_01695	COG0039	L-malate dehydrogenase activity
QR42_01700	COG1620	l-lactate permease
QR42_01705	COG1609	Transcriptional regulator
QR42_01710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
QR42_01715	COG0561	phosphatase activity
QR42_01720	COG0673	inositol 2-dehydrogenase activity
QR42_01725	COG0738	Major facilitator superfamily
QR42_01730	COG1280	lysine exporter protein (LysE YggA)
QR42_01740	COG3403	YqcI/YcgG family
QR42_01745	COG1113	amino acid transport
QR42_01750	COG3665	Urea carboxylase-associated protein
QR42_01755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
QR42_01765	COG1012	belongs to the aldehyde dehydrogenase family
QR42_01770	COG0710	3-dehydroquinate dehydratase activity
QR42_01775	COG0028	Belongs to the TPP enzyme family
QR42_01785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
QR42_01790	COG2271	Major facilitator Superfamily
QR42_01800	COG1414	Transcriptional regulator
QR42_01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
QR42_01810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
QR42_01820	COG0477	Major facilitator Superfamily
QR42_01825	COG2226	methyltransferase
QR42_01830	COG0583	DNA-binding transcription factor activity
QR42_01835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
QR42_01840	COG3458	cephalosporin-C deacetylase activity
QR42_01850	COG3541	Predicted nucleotidyltransferase
QR42_01855	COG0506	proline dehydrogenase activity
QR42_01860	COG1012	belongs to the aldehyde dehydrogenase family
QR42_01865	COG2508	Transcriptional regulator
QR42_01870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
QR42_01875	COG0765	amino acid transport
QR42_01880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_01890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
QR42_01895	COG1522	sequence-specific DNA binding
QR42_01900	COG2746	aminoglycoside 3-N-acetyltransferase activity
QR42_01910	COG0840	transmembrane signaling receptor activity
QR42_01910	COG3290	protein histidine kinase activity
QR42_01915	COG3209	COG3209 Rhs family protein
QR42_01940	COG3842	ATPase activity
QR42_01945	COG1176	ABC-type spermidine putrescine transport system, permease component I
QR42_01955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QR42_01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QR42_01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QR42_01980	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
QR42_01985	COG0697	spore germination
QR42_01990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QR42_02005	COG2364	Membrane
QR42_02010	COG0737	Belongs to the 5'-nucleotidase family
QR42_02015	COG3764	Sortase (surface protein transpeptidase)
QR42_02020	COG2002	toxin-antitoxin pair type II binding
QR42_02025	COG1126	abc transporter atp-binding protein
QR42_02030	COG0765	amino acid transport
QR42_02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_02040	COG0833	amino acid
QR42_02050	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_02055	COG1312	Catalyzes the dehydration of D-mannonate
QR42_02060	COG1802	Transcriptional regulator
QR42_02065	COG0673	inositol 2-dehydrogenase activity
QR42_02080	COG3104	oligopeptide transport
QR42_02085	COG5434	Belongs to the glycosyl hydrolase 28 family
QR42_02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_02105	COG0765	amino acid transport
QR42_02110	COG1126	abc transporter atp-binding protein
QR42_02120	COG2079	MmgE PrpD family protein
QR42_02130	COG0745	RESPONSE REGULATOR receiver
QR42_02135	COG5002	protein histidine kinase activity
QR42_02135	COG3850	Histidine kinase
QR42_02140	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_02145	COG0527	aspartate kinase activity
QR42_02150	COG2814	Major facilitator Superfamily
QR42_02155	COG1309	transcriptional regulator
QR42_02165	COG0640	Transcriptional regulator
QR42_02170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QR42_02175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
QR42_02180	COG0531	amino acid
QR42_02185	COG1012	belongs to the aldehyde dehydrogenase family
QR42_02190	COG2249	NAD(P)H dehydrogenase (quinone) activity
QR42_02195	COG4549	nuclear export factor GLE1
QR42_02200	COG2372	response to copper ion
QR42_02200	COG1276	copper resistance
QR42_02205	COG2213	PTS system mannitol-specific
QR42_02210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_02215	COG0246	Mannitol dehydrogenase
QR42_02220	COG0840	transmembrane signaling receptor activity
QR42_02240	COG0346	lactoylglutathione lyase activity
QR42_02250	COG0561	phosphatase activity
QR42_02255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
QR42_02260	COG1914	H( )-stimulated, divalent metal cation uptake system
QR42_02265	COG4336	lyase activity
QR42_02270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
QR42_02275	COG1984	allophanate hydrolase subunit 2
QR42_02280	COG1414	Transcriptional regulator
QR42_02285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
QR42_02290	COG2755	lipolytic protein G-D-S-L family
QR42_02300	COG3711	transcriptional antiterminator
QR42_02305	COG2226	methyltransferase
QR42_02310	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_02315	COG3871	stress protein (general stress protein 26)
QR42_02335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
QR42_02360	COG0602	queuosine metabolic process
QR42_02365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
QR42_02375	COG0302	gtp cyclohydrolase
QR42_02380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
QR42_02385	COG0189	ligase activity
QR42_02400	COG2814	Major facilitator Superfamily
QR42_02405	COG1802	Transcriptional regulator
QR42_02410	COG1917	Cupin 2, conserved barrel domain protein
QR42_02410	COG2207	Transcriptional regulator
QR42_02415	COG0697	spore germination
QR42_02420	COG0473	3-isopropylmalate dehydrogenase activity
QR42_02425	COG0551	DNA topoisomerase type I activity
QR42_02425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
QR42_02430	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
QR42_02435	COG3706	GGDEF domain
QR42_02440	COG5298	Protein conserved in bacteria
QR42_02445	COG1215	transferase activity, transferring glycosyl groups
QR42_02455	COG0531	amino acid
QR42_02460	COG0028	Belongs to the TPP enzyme family
QR42_02465	COG5444	nuclease activity
QR42_02485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QR42_02490	COG1914	H( )-stimulated, divalent metal cation uptake system
QR42_02495	COG2261	transglycosylase associated protein
QR42_02500	COG2217	Heavy metal translocating P-type atpase
QR42_02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
QR42_02510	COG3290	protein histidine kinase activity
QR42_02515	COG4565	transcriptional regulatory protein
QR42_02520	COG1301	dicarboxylic acid transport
QR42_02525	COG0628	permease
QR42_02530	COG1301	dicarboxylic acid transport
QR42_02535	COG1131	(ABC) transporter
QR42_02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
QR42_02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_02555	COG1181	Belongs to the D-alanine--D-alanine ligase family
QR42_02560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
QR42_02575	COG0513	Belongs to the DEAD box helicase family
QR42_02580	COG3402	PFAM membrane-flanked domain
QR42_02585	COG3428	Bacterial PH domain
QR42_02590	COG0705	Rhomboid family
QR42_02595	COG0736	holo-[acyl-carrier-protein] synthase activity
QR42_02600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
QR42_02605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
QR42_02610	COG0864	Transcriptional regulator
QR42_02615	COG2337	Toxic component of a toxin-antitoxin (TA) module
QR42_02620	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_02625	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_02630	COG2172	sigma factor antagonist activity
QR42_02635	COG2208	phosphoserine phosphatase activity
QR42_02640	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_02645	COG2172	sigma factor antagonist activity
QR42_02650	COG1191	sigma factor activity
QR42_02655	COG2208	phosphoserine phosphatase activity
QR42_02660	COG2183	response to ionizing radiation
QR42_02665	COG3091	SprT-like family
QR42_02670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
QR42_02675	COG0022	dehydrogenase e1 component
QR42_02680	COG0508	dehydrogenase complex catalyzes the overall conversion of
QR42_02685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
QR42_02690	COG3284	Transcriptional regulator
QR42_02735	COG1278	Cold shock
QR42_02740	COG1329	Transcriptional regulator
QR42_02745	COG1064	alcohol dehydrogenase
QR42_02750	COG0789	Transcriptional regulator
QR42_02765	COG0477	Major facilitator Superfamily
QR42_02780	COG0583	DNA-binding transcription factor activity
QR42_02795	COG4221	oxidoreductase activity
QR42_02805	COG0252	asparaginase activity
QR42_02825	COG2814	Major facilitator Superfamily
QR42_02830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QR42_02860	COG1309	transcriptional regulator
QR42_02865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
QR42_02870	COG1846	Transcriptional regulator
QR42_02875	COG0778	Nitroreductase
QR42_02890	COG1396	sequence-specific DNA binding
QR42_02920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
QR42_02925	COG0697	spore germination
QR42_02935	COG1301	dicarboxylic acid transport
QR42_02975	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
QR42_02980	COG0802	atpase or kinase
QR42_02985	COG1214	PFAM Peptidase M22, glycoprotease
QR42_02990	COG0456	acetyltransferase
QR42_02995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
QR42_03000	COG0488	(ABC) transporter
QR42_03005	COG0315	cyclic pyranopterin monophosphate synthase activity
QR42_03010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
QR42_03015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
QR42_03020	COG0805	protein transport
QR42_03035	COG1266	CAAX protease self-immunity
QR42_03040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
QR42_03045	COG0459	protein refolding
QR42_03085	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
QR42_03090	COG0823	Involved in the tonB-independent uptake of proteins
QR42_03100	COG2132	Multicopper oxidase
QR42_03105	COG1113	amino acid transport
QR42_03110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
QR42_03115	COG0714	Associated with various cellular activities
QR42_03120	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
QR42_03125	COG1305	Transglutaminase-like
QR42_03130	COG0519	Catalyzes the synthesis of GMP from XMP
QR42_03130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
QR42_03135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
QR42_03145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
QR42_03175	COG1595	DNA-templated transcription, initiation
QR42_03185	COG2814	Major facilitator Superfamily
QR42_03190	COG0583	DNA-binding transcription factor activity
QR42_03195	COG2252	PERMEase
QR42_03205	COG3064	Membrane
QR42_03210	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
QR42_03220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
QR42_03225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
QR42_03230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
QR42_03235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
QR42_03240	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
QR42_03245	COG0047	phosphoribosylformylglycinamidine synthase activity
QR42_03250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
QR42_03255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
QR42_03260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
QR42_03265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
QR42_03270	COG0138	bifunctional purine biosynthesis protein purh
QR42_03275	COG0151	Belongs to the GarS family
QR42_03295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
QR42_03300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
QR42_03305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
QR42_03310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
QR42_03320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
QR42_03325	COG4496	protein, YerC YecD
QR42_03330	COG0069	glutamate synthase activity
QR42_03345	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
QR42_03350	COG0210	DNA helicase
QR42_03355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
QR42_03360	COG4851	CamS sex pheromone cAM373 precursor
QR42_03365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QR42_03370	COG1285	pathogenesis
QR42_03375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QR42_03380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
QR42_03385	COG0154	amidase activity
QR42_03390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
QR42_03395	COG1309	transcriptional regulator
QR42_03400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
QR42_03405	COG1957	nucleoside hydrolase
QR42_03410	COG1597	lipid kinase activity
QR42_03415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
QR42_03420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
QR42_03430	COG1737	Transcriptional regulator
QR42_03435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_03435	COG1263	PTS System
QR42_03440	COG1486	melibiose metabolic process
QR42_03450	COG1959	2 iron, 2 sulfur cluster binding
QR42_03455	COG0492	ferredoxin-NADP+ reductase activity
QR42_03470	COG1486	melibiose metabolic process
QR42_03480	COG2211	Major facilitator Superfamily
QR42_03505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
QR42_03510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
QR42_03515	COG1442	glycosyl transferase family 8
QR42_03520	COG1216	Glycosyl transferase, family 2
QR42_03525	COG1442	glycosyl transferase family 8
QR42_03530	COG2223	nitrite transmembrane transporter activity
QR42_03545	COG0693	protein deglycase activity
QR42_03560	COG0071	Belongs to the small heat shock protein (HSP20) family
QR42_03575	COG0531	amino acid
QR42_03580	COG0463	Glycosyl transferase, family 2
QR42_03585	COG0488	(ABC) transporter
QR42_03590	COG1469	GTP cyclohydrolase I activity
QR42_03595	COG0789	Transcriptional regulator
QR42_03600	COG2814	Major facilitator Superfamily
QR42_03605	COG0488	(ABC) transporter
QR42_03610	COG0513	Belongs to the DEAD box helicase family
QR42_03625	COG2130	NADP-dependent
QR42_03645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
QR42_03645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
QR42_03650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
QR42_03660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
QR42_03660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
QR42_03675	COG3290	protein histidine kinase activity
QR42_03680	COG4565	transcriptional regulatory protein
QR42_03685	COG3181	Tripartite tricarboxylate transporter family receptor
QR42_03690	COG2851	Citrate transporter
QR42_03700	COG3479	Phenolic acid decarboxylase
QR42_03705	COG1695	Transcriptional regulator
QR42_03710	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
QR42_03715	COG1254	Belongs to the acylphosphatase family
QR42_03720	COG2258	MOSC domain
QR42_03725	COG0024	Methionine aminopeptidase
QR42_03730	COG1263	PTS System
QR42_03730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_03735	COG3739	integral membrane protein
QR42_03755	COG1368	sulfuric ester hydrolase activity
QR42_03760	COG0076	glutamate decarboxylase activity
QR42_03775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_03775	COG1263	PTS System
QR42_03780	COG0366	Alpha amylase catalytic
QR42_03785	COG2188	Transcriptional regulator
QR42_03795	COG0737	Belongs to the 5'-nucleotidase family
QR42_03800	COG0693	protein deglycase activity
QR42_03805	COG4840	Belongs to the UPF0435 family
QR42_03810	COG1115	amino acid carrier protein
QR42_03815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
QR42_03820	COG4980	gas vesicle protein
QR42_03825	COG1295	ribonuclease BN
QR42_03830	COG0477	Major facilitator Superfamily
QR42_03840	COG0387	Pfam Sodium calcium exchanger
QR42_03850	COG0217	transcriptional regulatory protein
QR42_03860	COG0668	transmembrane transport
QR42_03865	COG0535	radical SAM domain protein
QR42_03875	COG0726	polysaccharide deacetylase
QR42_03880	COG0598	Magnesium transport protein CorA
QR42_03890	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
QR42_03895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
QR42_03910	COG0789	Transcriptional regulator
QR42_03915	COG2814	Major facilitator Superfamily
QR42_03925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
QR42_03970	COG2076	Multidrug Resistance protein
QR42_03975	COG2076	Multidrug Resistance protein
QR42_03980	COG1309	transcriptional regulator
QR42_03990	COG4637	Psort location Cytoplasmic, score
QR42_03995	COG2755	lipolytic protein G-D-S-L family
QR42_04000	COG0492	ferredoxin-NADP+ reductase activity
QR42_04005	COG0662	Cupin 2, conserved barrel domain protein
QR42_04005	COG2207	Transcriptional regulator
QR42_04010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_04015	COG1132	(ABC) transporter
QR42_04020	COG1742	UPF0060 membrane protein
QR42_04025	COG1595	DNA-templated transcription, initiation
QR42_04055	COG1846	Transcriptional regulator
QR42_04060	COG0392	lysyltransferase activity
QR42_04060	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
QR42_04080	COG0778	Nitroreductase
QR42_04090	COG1090	epimerase
QR42_04095	COG2137	regulation of response to DNA damage stimulus
QR42_04115	COG0463	Glycosyl transferase, family 2
QR42_04120	COG4485	Bacterial membrane protein, YfhO
QR42_04130	COG2140	Oxalate decarboxylase
QR42_04135	COG1191	sigma factor activity
QR42_04145	COG1988	membrane-bound metal-dependent
QR42_04150	COG1194	a g-specific adenine glycosylase
QR42_04160	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_04175	COG3557	Belongs to the UPF0374 family
QR42_04180	COG1132	(ABC) transporter
QR42_04185	COG0444	Belongs to the ABC transporter superfamily
QR42_04190	COG4608	Belongs to the ABC transporter superfamily
QR42_04195	COG0747	negative chemotaxis
QR42_04210	COG4129	membrane
QR42_04215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
QR42_04220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
QR42_04225	COG0735	belongs to the Fur family
QR42_04375	COG1368	sulfuric ester hydrolase activity
QR42_04380	COG0681	Belongs to the peptidase S26 family
QR42_04395	COG1116	anion transmembrane transporter activity
QR42_04400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
QR42_04405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
QR42_04420	COG1131	(ABC) transporter
QR42_04450	COG3382	B3 4 domain protein
QR42_04455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
QR42_04465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
QR42_04475	COG2766	serine protein kinase
QR42_04480	COG2718	Belongs to the UPF0229 family
QR42_04485	COG1566	PFAM secretion protein HlyD family protein
QR42_04490	COG2814	Major facilitator Superfamily
QR42_04495	COG0655	NAD(P)H dehydrogenase (quinone) activity
QR42_04505	COG1278	Cold shock
QR42_04510	COG3706	GGDEF domain
QR42_04535	COG5577	PFAM Coat F domain
QR42_04540	COG5002	protein histidine kinase activity
QR42_04545	COG1525	nuclease
QR42_04545	COG4085	toxin activity
QR42_04545	COG0737	Belongs to the 5'-nucleotidase family
QR42_04550	COG3764	Sortase (surface protein transpeptidase)
QR42_04555	COG0564	pseudouridine synthase activity
QR42_04565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
QR42_04570	COG3153	acetyltransferase
QR42_04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
QR42_04585	COG3835	regulator
QR42_04590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
QR42_04595	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
QR42_04600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
QR42_04605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
QR42_04610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
QR42_04615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
QR42_04620	COG2203	Gaf domain
QR42_04620	COG4585	Histidine kinase
QR42_04625	COG2197	response regulator
QR42_04645	COG0753	catalase activity
QR42_04650	COG1959	2 iron, 2 sulfur cluster binding
QR42_04655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
QR42_04655	COG1017	nitric oxide dioxygenase activity
QR42_04660	COG2719	SpoVR family
QR42_04665	COG1785	Belongs to the alkaline phosphatase family
QR42_04670	COG0791	NLP P60 protein
QR42_04670	COG1388	LysM domain
QR42_04675	COG0531	amino acid
QR42_04690	COG1595	DNA-templated transcription, initiation
QR42_04695	COG0204	Acyl-transferase
QR42_04700	COG1253	flavin adenine dinucleotide binding
QR42_04705	COG0789	Transcriptional regulator
QR42_04710	COG1253	flavin adenine dinucleotide binding
QR42_04720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
QR42_04725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
QR42_04730	COG0584	glycerophosphoryl diester phosphodiesterase
QR42_04735	COG0668	transmembrane transport
QR42_04740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
QR42_04750	COG0477	Major facilitator Superfamily
QR42_04755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
QR42_04765	COG0726	polysaccharide deacetylase
QR42_04770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QR42_04775	COG0589	response to stress
QR42_04780	COG1132	(ABC) transporter
QR42_04785	COG1132	(ABC) transporter
QR42_04795	COG0702	epimerase
QR42_04805	COG3842	ATPase activity
QR42_04810	COG2508	Transcriptional regulator
QR42_04820	COG0189	ligase activity
QR42_04825	COG0189	ligase activity
QR42_04830	COG4399	Belongs to the UPF0754 family
QR42_04835	COG3679	Belongs to the UPF0342 family
QR42_04840	COG0561	phosphatase activity
QR42_04845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
QR42_04855	COG0475	glutathione-regulated potassium exporter activity
QR42_04860	COG0490	domain, Protein
QR42_04875	COG1024	Enoyl-CoA hydratase
QR42_04885	COG0420	3'-5' exonuclease activity
QR42_04890	COG4717	serine-type aminopeptidase activity
QR42_04895	COG3481	metal-dependent phosphohydrolase, HD sub domain
QR42_04905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
QR42_04930	COG1846	Transcriptional regulator
QR42_04935	COG4980	gas vesicle protein
QR42_04950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
QR42_04955	COG0537	adenosine 5'-monophosphoramidase activity
QR42_04960	COG1131	(ABC) transporter
QR42_04965	COG4473	ABC transporter
QR42_04975	COG1473	amidohydrolase
QR42_04985	COG2329	Antibiotic biosynthesis monooxygenase
QR42_04990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QR42_04995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
QR42_05010	COG1309	transcriptional regulator
QR42_05015	COG1511	domain protein
QR42_05020	COG1363	Peptidase, m42
QR42_05025	COG1301	dicarboxylic acid transport
QR42_05030	COG1234	tRNA 3'-trailer cleavage
QR42_05035	COG0095	Lipoate-protein ligase
QR42_05040	COG0318	PFAM AMP-dependent synthetase and ligase
QR42_05050	COG0501	Belongs to the peptidase M48B family
QR42_05055	COG1404	Belongs to the peptidase S8 family
QR42_05060	COG0406	alpha-ribazole phosphatase activity
QR42_05065	COG0840	transmembrane signaling receptor activity
QR42_05070	COG0723	plastoquinol--plastocyanin reductase activity
QR42_05070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
QR42_05075	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_05085	COG4903	ComK protein
QR42_05095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QR42_05100	COG2814	Major facilitator Superfamily
QR42_05105	COG2732	(Barnase) inhibitor
QR42_05110	COG1316	TRANSCRIPTIONal
QR42_05120	COG0398	Pfam SNARE associated Golgi protein
QR42_05125	COG0681	Belongs to the peptidase S26 family
QR42_05130	COG3180	Ammonia monooxygenase
QR42_05140	COG0501	Belongs to the peptidase M48B family
QR42_05145	COG2259	Doxx family
QR42_05150	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
QR42_05155	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
QR42_05160	COG1074	ATP-dependent DNA helicase activity
QR42_05165	COG0420	3'-5' exonuclease activity
QR42_05170	COG0419	ATPase involved in DNA repair
QR42_05175	COG1403	HNH endonuclease
QR42_05215	COG5337	Spore coat protein CotH
QR42_05220	COG0179	Fumarylacetoacetate (FAA) hydrolase
QR42_05235	COG0367	asparagine synthase
QR42_05250	COG1562	ergosterol biosynthetic process
QR42_05255	COG0534	Mate efflux family protein
QR42_05260	COG2207	Transcriptional regulator
QR42_05260	COG1917	Cupin 2, conserved barrel domain protein
QR42_05290	COG0076	glutamate decarboxylase activity
QR42_05320	COG0646	methionine synthase
QR42_05320	COG1410	methionine synthase
QR42_05325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
QR42_05325	COG0646	methionine synthase
QR42_05330	COG1666	GTP binding
QR42_05335	COG2996	Protein conserved in bacteria
QR42_05345	COG0840	transmembrane signaling receptor activity
QR42_05350	COG1307	EDD domain protein, DegV family
QR42_05355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QR42_05375	COG0561	phosphatase activity
QR42_05380	COG1073	alpha beta
QR42_05385	COG2151	metal-sulfur cluster biosynthetic enzyme
QR42_05390	COG0277	FAD linked oxidase domain protein
QR42_05395	COG2271	Major facilitator Superfamily
QR42_05400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
QR42_05410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
QR42_05415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
QR42_05420	COG0505	Belongs to the CarA family
QR42_05425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
QR42_05430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
QR42_05440	COG2814	Major facilitator Superfamily
QR42_05450	COG2267	carboxylic ester hydrolase activity
QR42_05460	COG1744	ABC transporter substrate-binding protein PnrA-like
QR42_05475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
QR42_05480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
QR42_05485	COG5504	Zn-dependent protease
QR42_05490	COG0444	Belongs to the ABC transporter superfamily
QR42_05495	COG4608	Belongs to the ABC transporter superfamily
QR42_05505	COG0601	transmembrane transport
QR42_05510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
QR42_05520	COG0180	Tryptophanyl-tRNA synthetase
QR42_05525	COG4166	transmembrane transport
QR42_05530	COG0601	transmembrane transport
QR42_05535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
QR42_05540	COG0444	Belongs to the ABC transporter superfamily
QR42_05545	COG4608	Belongs to the ABC transporter superfamily
QR42_05555	COG0456	acetyltransferase
QR42_05560	COG1393	Belongs to the ArsC family
QR42_05565	COG0861	Integral membrane protein TerC family
QR42_05570	COG4862	establishment of competence for transformation
QR42_05575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
QR42_05585	COG1164	Oligoendopeptidase f
QR42_05600	COG2346	COG2346, Truncated hemoglobins
QR42_05605	COG0741	lytic transglycosylase activity
QR42_05610	COG4116	CYTH
QR42_05620	COG2357	RelA SpoT domain protein
QR42_05625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
QR42_05630	COG0564	pseudouridine synthase activity
QR42_05635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
QR42_05640	COG0569	domain protein
QR42_05640	COG0475	glutathione-regulated potassium exporter activity
QR42_05645	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
QR42_05650	COG0352	thiamine-phosphate diphosphorylase activity
QR42_05660	COG2104	thiamine diphosphate biosynthetic process
QR42_05665	COG2022	thiamine diphosphate biosynthetic process
QR42_05670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
QR42_05675	COG0351	phosphomethylpyrimidine kinase
QR42_05680	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
QR42_05735	COG0210	DNA helicase
QR42_05745	COG2153	protein acetylation
QR42_05750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
QR42_05755	COG2382	esterase
QR42_05760	COG0626	cystathionine gamma-synthase activity
QR42_05765	COG0626	cystathionine gamma-synthase activity
QR42_05780	COG0604	alcohol dehydrogenase
QR42_05790	COG0825	malonyl-CoA metabolic process
QR42_05800	COG2723	6-phospho-beta-galactosidase activity
QR42_05805	COG0589	response to stress
QR42_05815	COG2807	transmembrane transport
QR42_05825	COG0583	DNA-binding transcription factor activity
QR42_05845	COG0457	Tetratricopeptide repeat
QR42_05855	COG5444	nuclease activity
QR42_05880	COG0583	DNA-binding transcription factor activity
QR42_05885	COG2807	transmembrane transport
QR42_05905	COG0457	Tetratricopeptide repeat
QR42_05930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
QR42_05950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
QR42_05955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
QR42_05960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
QR42_05980	COG4195	phage-related replication protein
QR42_05985	COG2856	Zn peptidase
QR42_05990	COG5632	N-Acetylmuramoyl-L-alanine amidase
QR42_05990	COG3409	Peptidoglycan-binding domain 1 protein
QR42_06005	COG0306	phosphate transporter
QR42_06010	COG1392	Phosphate transport regulator
QR42_06020	COG0405	Gamma-glutamyltransferase
QR42_06025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
QR42_06035	COG4208	sulfate ABC transporter
QR42_06050	COG3775	system Galactitol-specific IIC component
QR42_06065	COG1063	alcohol dehydrogenase
QR42_06070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
QR42_06075	COG0508	dehydrogenase complex catalyzes the overall conversion of
QR42_06075	COG0022	dehydrogenase e1 component
QR42_06080	COG0508	dehydrogenase complex catalyzes the overall conversion of
QR42_06085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
QR42_06090	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_06095	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_06100	COG2390	Transcriptional regulator
QR42_06110	COG0531	amino acid
QR42_06115	COG0346	lactoylglutathione lyase activity
QR42_06120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QR42_06125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
QR42_06130	COG2362	D-Aminopeptidase
QR42_06135	COG0601	transmembrane transport
QR42_06140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
QR42_06145	COG0444	Belongs to the ABC transporter superfamily
QR42_06150	COG4166	transmembrane transport
QR42_06155	COG1619	proteins homologs of microcin C7 resistance protein MccF
QR42_06160	COG4948	Mandelate Racemase Muconate Lactonizing
QR42_06165	COG0791	NLP P60 protein
QR42_06170	COG4608	Belongs to the ABC transporter superfamily
QR42_06175	COG1834	amidinotransferase
QR42_06180	COG1607	acyl-coa hydrolase
QR42_06200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QR42_06210	COG2076	Multidrug Resistance protein
QR42_06215	COG2076	Multidrug Resistance protein
QR42_06225	COG0788	formyltetrahydrofolate deformylase activity
QR42_06230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
QR42_06235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
QR42_06240	COG0457	Tetratricopeptide repeat
QR42_06250	COG1764	response to oxidative stress
QR42_06255	COG1846	Transcriptional regulator
QR42_06260	COG1764	response to oxidative stress
QR42_06265	COG0590	tRNA wobble adenosine to inosine editing
QR42_06270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
QR42_06275	COG1404	Belongs to the peptidase S8 family
QR42_06290	COG0745	RESPONSE REGULATOR receiver
QR42_06295	COG5002	protein histidine kinase activity
QR42_06295	COG3850	Histidine kinase
QR42_06300	COG3212	peptidase
QR42_06305	COG3212	peptidase
QR42_06310	COG2239	Acts as a magnesium transporter
QR42_06320	COG0583	DNA-binding transcription factor activity
QR42_06330	COG0789	Transcriptional regulator
QR42_06340	COG1846	Transcriptional regulator
QR42_06345	COG5001	Diguanylate cyclase
QR42_06345	COG3300	MHYT domain
QR42_06350	COG0586	Pfam SNARE associated Golgi protein
QR42_06355	COG0861	Integral membrane protein TerC family
QR42_06360	COG1191	sigma factor activity
QR42_06380	COG0501	Belongs to the peptidase M48B family
QR42_06385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
QR42_06390	COG2323	membrane
QR42_06395	COG3594	Acyltransferase
QR42_06400	COG5002	protein histidine kinase activity
QR42_06405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
QR42_06410	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
QR42_06415	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
QR42_06420	COG0436	Aminotransferase
QR42_06425	COG1850	ribulose-bisphosphate carboxylase activity
QR42_06430	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
QR42_06435	COG0235	Class ii aldolase
QR42_06440	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
QR42_06450	COG3852	Histidine kinase
QR42_06455	COG1846	Transcriptional regulator
QR42_06460	COG1360	Flagellar Motor Protein
QR42_06465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
QR42_06470	COG0542	response to heat
QR42_06475	COG3949	Membrane
QR42_06480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
QR42_06485	COG0720	synthase
QR42_06490	COG0602	queuosine metabolic process
QR42_06495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
QR42_06515	COG4873	Protein conserved in bacteria
QR42_06525	COG3773	Cell wall hydrolase
QR42_06530	COG2244	polysaccharide biosynthetic process
QR42_06535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_06540	COG2217	Heavy metal translocating P-type atpase
QR42_06545	COG0006	proline dipeptidase activity
QR42_06550	COG1609	Transcriptional regulator
QR42_06555	COG3711	transcriptional antiterminator
QR42_06560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_06560	COG2190	(PTS) system
QR42_06560	COG1263	PTS System
QR42_06565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_06570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
QR42_06580	COG1533	DNA photolyase activity
QR42_06585	COG0840	transmembrane signaling receptor activity
QR42_06595	COG2084	Dehydrogenase
QR42_06600	COG2340	Cysteine-rich secretory protein family
QR42_06605	COG0768	penicillin binding
QR42_06610	COG4191	Histidine kinase
QR42_06615	COG0436	Aminotransferase
QR42_06620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
QR42_06625	COG1714	RDD family
QR42_06635	COG0835	chemotaxis
QR42_06635	COG0784	Response regulator, receiver
QR42_06645	COG2207	Transcriptional regulator
QR42_06645	COG1917	Cupin 2, conserved barrel domain protein
QR42_06650	COG0697	spore germination
QR42_06660	COG2814	Major facilitator Superfamily
QR42_06665	COG1376	ErfK ybiS ycfS ynhG family protein
QR42_06670	COG1408	metallophosphoesterase
QR42_06675	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_06680	COG2200	EAL domain
QR42_06685	COG3546	catalase activity
QR42_06690	COG4703	Protein of unknown function (DUF1797)
QR42_06695	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
QR42_06705	COG0517	IMP dehydrogenase activity
QR42_06710	COG0583	DNA-binding transcription factor activity
QR42_06715	COG0716	FMN binding
QR42_06725	COG0716	FMN binding
QR42_06730	COG2171	N-acyltransferase activity
QR42_06735	COG1473	amidohydrolase
QR42_06745	COG0668	transmembrane transport
QR42_06750	COG0450	alkyl hydroperoxide reductase
QR42_06755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_06770	COG0746	molybdenum cofactor guanylyltransferase activity
QR42_06775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
QR42_06780	COG0303	'Molybdopterin
QR42_06785	COG1763	Mo-molybdopterin cofactor biosynthetic process
QR42_06790	COG0314	molybdopterin synthase activity
QR42_06795	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
QR42_06810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
QR42_06815	COG1136	(ABC) transporter
QR42_06820	COG0577	efflux transmembrane transporter activity
QR42_06825	COG1349	DNA-binding transcription factor activity
QR42_06830	COG1105	Belongs to the carbohydrate kinase PfkB family
QR42_06835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_06835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_06835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_06850	COG0488	(ABC) transporter
QR42_06855	COG2309	aminopeptidase activity
QR42_06860	COG1077	Cell shape determining protein MreB Mrl
QR42_06865	COG2002	toxin-antitoxin pair type II binding
QR42_06870	COG3852	Histidine kinase
QR42_06875	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
QR42_06875	COG2105	PFAM AIG2 family protein
QR42_06880	COG0569	domain protein
QR42_06885	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
QR42_06890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
QR42_06900	COG0561	phosphatase activity
QR42_06905	COG0242	peptide deformylase activity
QR42_06920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
QR42_06925	COG0022	dehydrogenase e1 component
QR42_06930	COG0508	dehydrogenase complex catalyzes the overall conversion of
QR42_06935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
QR42_06940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_06950	COG1982	Orn Lys Arg decarboxylase major
QR42_06955	COG4476	Belongs to the UPF0223 family
QR42_06960	COG4493	Belongs to the UPF0637 family
QR42_06970	COG0483	inositol monophosphate 1-phosphatase activity
QR42_06985	COG1595	DNA-templated transcription, initiation
QR42_07015	COG4896	Protein conserved in bacteria
QR42_07025	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
QR42_07030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
QR42_07035	COG2066	Belongs to the glutaminase family
QR42_07040	COG4838	Belongs to the UPF0358 family
QR42_07045	COG0772	Belongs to the SEDS family
QR42_07050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
QR42_07060	COG1612	heme a metabolic process
QR42_07065	COG0109	protoheme IX farnesyltransferase activity
QR42_07070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
QR42_07070	COG2010	Cytochrome c
QR42_07075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
QR42_07080	COG1845	cytochrome c oxidase, subunit III
QR42_07085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
QR42_07090	COG3336	cytochrome c oxidase
QR42_07100	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
QR42_07105	COG2340	Cysteine-rich secretory protein family
QR42_07125	COG3679	Belongs to the UPF0342 family
QR42_07130	COG4471	UPF0298 protein
QR42_07135	COG0742	ribosomal rna small subunit methyltransferase
QR42_07140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
QR42_07145	COG3314	Sporulation integral membrane protein YlbJ
QR42_07150	COG1752	Esterase of the alpha-beta hydrolase superfamily
QR42_07155	COG3480	Lon protease (S16) C-terminal proteolytic domain
QR42_07160	COG1323	Belongs to the UPF0348 family
QR42_07165	COG1399	metal-binding, possibly nucleic acid-binding protein
QR42_07170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
QR42_07180	COG0454	-acetyltransferase
QR42_07185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
QR42_07190	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
QR42_07195	COG2001	Belongs to the MraZ family
QR42_07200	COG0275	rRNA processing
QR42_07205	COG4839	cell division protein FtsL
QR42_07215	COG0768	penicillin binding
QR42_07220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
QR42_07225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
QR42_07230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
QR42_07235	COG0772	Belongs to the SEDS family
QR42_07240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
QR42_07245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
QR42_07250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
QR42_07255	COG3879	Bacterial protein of unknown function (DUF881)
QR42_07260	COG3879	Bacterial protein of unknown function (DUF881)
QR42_07265	COG3856	small basic protein
QR42_07270	COG0849	cell division
QR42_07275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
QR42_07280	COG4412	M6 family metalloprotease domain protein
QR42_07280	COG1404	Belongs to the peptidase S8 family
QR42_07290	COG1191	sigma factor activity
QR42_07295	COG1191	sigma factor activity
QR42_07300	COG2390	Transcriptional regulator
QR42_07315	COG3730	PTS system glucitol sorbitol-specific
QR42_07320	COG3732	PTS system glucitol sorbitol-specific
QR42_07330	COG1119	ATPase activity
QR42_07335	COG1873	PFAM PRC-barrel domain
QR42_07345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
QR42_07350	COG1799	cell septum assembly
QR42_07355	COG0762	integral membrane protein
QR42_07360	COG2302	S4 RNA-binding domain
QR42_07365	COG3599	regulation of cell shape
QR42_07370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
QR42_07375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
QR42_07380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
QR42_07385	COG0564	pseudouridine synthase activity
QR42_07390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
QR42_07395	COG2233	PERMEase
QR42_07400	COG0540	Belongs to the ATCase OTCase family
QR42_07405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
QR42_07410	COG0505	Belongs to the CarA family
QR42_07415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
QR42_07420	COG0543	2 iron, 2 sulfur cluster binding
QR42_07425	COG0167	dihydroorotate dehydrogenase activity
QR42_07430	COG0284	orotidine-5'-phosphate decarboxylase activity
QR42_07435	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
QR42_07440	COG0175	sulfate reduction
QR42_07445	COG0306	phosphate transporter
QR42_07450	COG2046	Belongs to the sulfate adenylyltransferase family
QR42_07455	COG0529	Catalyzes the synthesis of activated sulfate
QR42_07460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
QR42_07465	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
QR42_07470	COG1648	precorrin-2 dehydrogenase activity
QR42_07480	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
QR42_07485	COG1561	YicC-like family, N-terminal region
QR42_07490	COG2052	Domain of unknown function (DUF370)
QR42_07495	COG0194	GDP metabolic process
QR42_07500	COG1758	RNA polymerase activity
QR42_07505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
QR42_07510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
QR42_07515	COG0242	peptide deformylase activity
QR42_07520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
QR42_07525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
QR42_07525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
QR42_07530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
QR42_07535	COG0631	protein serine/threonine phosphatase activity
QR42_07540	COG2815	serine threonine protein kinase
QR42_07540	COG0515	serine threonine protein kinase
QR42_07545	COG1162	GTPase activity
QR42_07550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
QR42_07555	COG1564	THIamine pyrophosphokinase
QR42_07565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
QR42_07570	COG1302	Protein conserved in bacteria
QR42_07575	COG1461	Dihydroxyacetone kinase
QR42_07580	COG1760	l-serine dehydratase
QR42_07585	COG1760	l-serine dehydratase
QR42_07590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
QR42_07595	COG1349	DNA-binding transcription factor activity
QR42_07600	COG0416	fatty acid biosynthetic process
QR42_07605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
QR42_07610	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_07615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QR42_07625	COG1196	nuclear chromosome segregation
QR42_07630	COG0552	protein localization to endoplasmic reticulum
QR42_07635	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
QR42_07640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
QR42_07645	COG0228	four-way junction DNA binding
QR42_07650	COG1837	Belongs to the UPF0109 family
QR42_07660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
QR42_07665	COG0336	Belongs to the RNA methyltransferase TrmD family
QR42_07670	COG0335	large ribosomal subunit rRNA binding
QR42_07675	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
QR42_07680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
QR42_07690	COG2257	FlhB HrpN YscU SpaS Family
QR42_07695	COG0045	succinate-CoA ligase (ADP-forming) activity
QR42_07700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
QR42_07705	COG0758	DNA mediated transformation
QR42_07710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
QR42_07715	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
QR42_07720	COG4974	Belongs to the 'phage' integrase family
QR42_07725	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
QR42_07730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
QR42_07735	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
QR42_07740	COG1815	bacterial-type flagellum-dependent cell motility
QR42_07745	COG1558	bacterial-type flagellum-dependent cell motility
QR42_07750	COG1677	Flagellar hook-basal body complex protein FliE
QR42_07755	COG1766	The M ring may be actively involved in energy transduction
QR42_07760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
QR42_07765	COG1317	bacterial-type flagellum organization
QR42_07770	COG1157	protein secretion by the type III secretion system
QR42_07775	COG2882	bacterial-type flagellum organization
QR42_07780	COG3334	PFAM MgtE intracellular
QR42_07785	COG3144	bacterial-type flagellum assembly
QR42_07790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
QR42_07795	COG4786	Flagellar basal body rod
QR42_07800	COG1582	Flagellar protein (FlbD)
QR42_07805	COG1580	Controls the rotational direction of flagella during chemotaxis
QR42_07810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
QR42_07815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
QR42_07815	COG1776	CheC inhibitor of MCP methylation
QR42_07820	COG2201	protein-glutamate methylesterase activity
QR42_07825	COG3190	flagellar
QR42_07830	COG1338	Plays a role in the flagellum-specific transport system
QR42_07835	COG1987	bacterial-type flagellum assembly
QR42_07840	COG1684	flagellar biosynthetic protein fliR
QR42_07845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
QR42_07850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
QR42_07855	COG1419	protein localization to endoplasmic reticulum
QR42_07860	COG0455	bacterial-type flagellum organization
QR42_07865	COG2201	protein-glutamate methylesterase activity
QR42_07870	COG0643	Histidine kinase
QR42_07870	COG2198	Histidine kinase
QR42_07875	COG0835	chemotaxis
QR42_07880	COG1776	CheC inhibitor of MCP methylation
QR42_07885	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
QR42_07890	COG1191	sigma factor activity
QR42_07905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
QR42_07910	COG0528	UMP kinase activity
QR42_07915	COG0233	cytoplasmic translational termination
QR42_07920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
QR42_07925	COG4589	Belongs to the CDS family
QR42_07930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
QR42_07935	COG0750	zinc metalloprotease
QR42_07940	COG0442	prolyl-tRNA aminoacylation
QR42_07945	COG2176	DNA-directed DNA polymerase activity
QR42_07980	COG1131	(ABC) transporter
QR42_08025	COG0779	Required for maturation of 30S ribosomal subunits
QR42_08030	COG0195	Participates in both transcription termination and antitermination
QR42_08035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
QR42_08040	COG1358	cellular component organization or biogenesis
QR42_08045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
QR42_08050	COG1550	Protein conserved in bacteria
QR42_08055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
QR42_08060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
QR42_08065	COG0196	riboflavin kinase activity
QR42_08070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
QR42_08075	COG1185	polyribonucleotide nucleotidyltransferase activity
QR42_08080	COG0726	polysaccharide deacetylase
QR42_08085	COG0612	Peptidase, M16
QR42_08095	COG1873	PFAM PRC-barrel domain
QR42_08100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
QR42_08105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
QR42_08110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
QR42_08115	COG0527	aspartate kinase activity
QR42_08125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
QR42_08130	COG0740	serine-type endopeptidase activity
QR42_08140	COG1674	ftsk spoiiie
QR42_08140	COG4980	gas vesicle protein
QR42_08145	COG2188	Transcriptional regulator
QR42_08150	COG2814	Major facilitator Superfamily
QR42_08155	COG1033	growth of symbiont in host cell
QR42_08155	COG2409	Drug exporters of the RND superfamily
QR42_08160	COG0612	Peptidase, M16
QR42_08165	COG0612	Peptidase, M16
QR42_08175	COG1033	growth of symbiont in host cell
QR42_08175	COG2409	Drug exporters of the RND superfamily
QR42_08180	COG0300	oxidoreductase activity
QR42_08195	COG1426	Protein conserved in bacteria
QR42_08200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
QR42_08205	COG1058	Belongs to the CinA family
QR42_08205	COG1546	Belongs to the CinA family
QR42_08210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
QR42_08215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
QR42_08220	COG1418	mRNA catabolic process
QR42_08225	COG1692	metallophosphoesterase
QR42_08230	COG2359	stage V sporulation protein S
QR42_08235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
QR42_08240	COG1063	alcohol dehydrogenase
QR42_08245	COG0156	8-amino-7-oxononanoate synthase activity
QR42_08250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
QR42_08255	COG4550	Control of competence regulator ComK, YlbF/YmcA
QR42_08265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
QR42_08270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
QR42_08290	COG1329	Transcriptional regulator
QR42_08295	COG4195	phage-related replication protein
QR42_08300	COG0457	Tetratricopeptide repeat
QR42_08305	COG1404	Belongs to the peptidase S8 family
QR42_08310	COG4195	phage-related replication protein
QR42_08315	COG1764	response to oxidative stress
QR42_08340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
QR42_08345	COG1923	regulation of RNA biosynthetic process
QR42_08360	COG1780	Probably involved in ribonucleotide reductase function
QR42_08365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
QR42_08370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
QR42_08375	COG4112	unkown
QR42_08385	COG0464	growth
QR42_08390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
QR42_08395	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
QR42_08400	COG0789	Transcriptional regulator
QR42_08405	COG0174	glutamine synthetase
QR42_08475	COG0457	Tetratricopeptide repeat
QR42_08480	COG5444	nuclease activity
QR42_08505	COG5646	InterPro IPR014922
QR42_08510	COG0457	Tetratricopeptide repeat
QR42_08515	COG3619	membrane
QR42_08520	COG1793	dna ligase
QR42_08520	COG3285	dna ligase
QR42_08525	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
QR42_08530	COG4876	unkown
QR42_08540	COG1959	2 iron, 2 sulfur cluster binding
QR42_08545	COG0702	epimerase
QR42_08550	COG0247	lactate metabolic process
QR42_08555	COG1139	Iron-sulfur cluster binding protein
QR42_08560	COG1556	Lactate utilization protein
QR42_08580	COG2323	membrane
QR42_08585	COG1309	transcriptional regulator
QR42_08590	COG2124	cytochrome p450
QR42_08590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
QR42_08595	COG3591	Belongs to the peptidase S1B family
QR42_08600	COG3209	COG3209 Rhs family protein
QR42_08605	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_08620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
QR42_08625	COG1388	LysM domain
QR42_08630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
QR42_08635	COG4224	UPF0291 protein
QR42_08640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
QR42_08650	COG3763	UPF0154 protein
QR42_08660	COG0785	Cytochrome C biogenesis protein
QR42_08665	COG4846	Membrane protein involved in cytochrome C biogenesis
QR42_08675	COG0071	Belongs to the small heat shock protein (HSP20) family
QR42_08690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
QR42_08695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_08715	COG0824	Thioesterase
QR42_08725	COG4841	protein insertion into membrane
QR42_08730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
QR42_08735	COG1832	CoA-binding protein
QR42_08740	COG0187	DNA topoisomerase II activity
QR42_08745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
QR42_08755	COG0738	Major facilitator superfamily
QR42_08760	COG2249	NAD(P)H dehydrogenase (quinone) activity
QR42_08765	COG1733	regulation of RNA biosynthetic process
QR42_08775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
QR42_08780	COG0251	oxidation-reduction process
QR42_08830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
QR42_08835	COG0583	DNA-binding transcription factor activity
QR42_08850	COG0657	acetylesterase activity
QR42_08855	COG0789	Transcriptional regulator
QR42_08860	COG2723	6-phospho-beta-galactosidase activity
QR42_08865	COG2190	(PTS) system
QR42_08865	COG1263	PTS System
QR42_08865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_08880	COG2205	protein histidine kinase activity
QR42_08885	COG0745	RESPONSE REGULATOR receiver
QR42_08895	COG3507	Belongs to the glycosyl hydrolase 43 family
QR42_08900	COG1012	belongs to the aldehyde dehydrogenase family
QR42_08905	COG1486	melibiose metabolic process
QR42_08930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
QR42_08945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_08950	COG0583	DNA-binding transcription factor activity
QR42_08955	COG1053	succinate dehydrogenase
QR42_08985	COG1846	Transcriptional regulator
QR42_08990	COG2814	Major facilitator Superfamily
QR42_09000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_09000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_09000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_09005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_09005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QR42_09005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_09010	COG1105	Belongs to the carbohydrate kinase PfkB family
QR42_09020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
QR42_09050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
QR42_09055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
QR42_09060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
QR42_09065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
QR42_09070	COG1024	Enoyl-CoA hydratase
QR42_09075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
QR42_09080	COG0511	ligase activity, forming carbon-carbon bonds
QR42_09085	COG0439	Biotin carboxylase
QR42_09090	COG0318	PFAM AMP-dependent synthetase and ligase
QR42_09095	COG1960	acyl-CoA dehydrogenase activity
QR42_09100	COG1649	PFAM Uncharacterised BCR, COG1649
QR42_09110	COG1349	DNA-binding transcription factor activity
QR42_09120	COG3835	regulator
QR42_09125	COG0277	FAD linked oxidase domain protein
QR42_09130	COG0247	lactate metabolic process
QR42_09155	COG0166	Belongs to the GPI family
QR42_09160	COG0586	Pfam SNARE associated Golgi protein
QR42_09165	COG1587	Uroporphyrinogen-III synthase
QR42_09175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QR42_09220	COG0534	Mate efflux family protein
QR42_09225	COG2027	D-alanyl-D-alanine carboxypeptidase
QR42_09230	COG4677	pectinesterase activity
QR42_09235	COG2323	membrane
QR42_09240	COG0493	'glutamate synthase
QR42_09245	COG0070	glutamate synthase
QR42_09245	COG0067	glutamate synthase
QR42_09245	COG0069	glutamate synthase activity
QR42_09250	COG0583	DNA-binding transcription factor activity
QR42_09260	COG1132	(ABC) transporter
QR42_09265	COG4978	Transcriptional regulator
QR42_09265	COG0789	Transcriptional regulator
QR42_09270	COG0454	-acetyltransferase
QR42_09275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
QR42_09280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
QR42_09295	COG0243	molybdopterin cofactor binding
QR42_09305	COG1070	Carbohydrate kinase
QR42_09310	COG2115	Belongs to the xylose isomerase family
QR42_09315	COG1940	carbohydrate kinase activity
QR42_09325	COG2211	Major facilitator Superfamily
QR42_09330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QR42_09335	COG1994	Peptidase M50
QR42_09355	COG1309	transcriptional regulator
QR42_09360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QR42_09365	COG3708	Transcriptional regulator
QR42_09370	COG2378	regulation of single-species biofilm formation
QR42_09380	COG0640	Transcriptional regulator
QR42_09385	COG0531	amino acid
QR42_09390	COG0741	lytic transglycosylase activity
QR42_09395	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
QR42_09400	COG2079	MmgE PrpD family protein
QR42_09405	COG0372	Belongs to the citrate synthase family
QR42_09410	COG2322	membrane
QR42_09420	COG3584	3D domain protein
QR42_09420	COG1388	LysM domain
QR42_09425	COG0514	ATP-dependent DNA helicase (RecQ)
QR42_09430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
QR42_09450	COG1012	belongs to the aldehyde dehydrogenase family
QR42_09455	COG1657	PFAM Prenyltransferase squalene oxidase
QR42_09460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
QR42_09465	COG0385	Bile acid
QR42_09470	COG0508	dehydrogenase complex catalyzes the overall conversion of
QR42_09475	COG0567	Dehydrogenase, E1 component
QR42_09480	COG4548	von Willebrand factor, type A
QR42_09485	COG0714	Associated with various cellular activities
QR42_09490	COG2032	superoxide dismutase activity
QR42_09495	COG1388	LysM domain
QR42_09495	COG0791	NLP P60 protein
QR42_09500	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
QR42_09505	COG0534	Mate efflux family protein
QR42_09510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
QR42_09515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
QR42_09525	COG2962	Rard protein
QR42_09540	COG1733	regulation of RNA biosynthetic process
QR42_09545	COG0778	Nitroreductase
QR42_09555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QR42_09560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
QR42_09565	COG0793	Belongs to the peptidase S41A family
QR42_09565	COG3409	Peptidoglycan-binding domain 1 protein
QR42_09570	COG2226	methyltransferase
QR42_09580	COG1876	peptidase activity
QR42_09585	COG0813	purine-nucleoside phosphorylase activity
QR42_09595	COG0671	phosphoesterase, PA-phosphatase related
QR42_09605	COG4479	Belongs to the UPF0346 family
QR42_09615	COG1509	lysine 2,3-aminomutase activity
QR42_09620	COG3829	transcription factor binding
QR42_09630	COG0463	Glycosyl transferase, family 2
QR42_09645	COG4641	Protein conserved in bacteria
QR42_09655	COG1086	Polysaccharide biosynthesis protein
QR42_09660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
QR42_09665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
QR42_09670	COG1846	Transcriptional regulator
QR42_09690	COG4698	Protein conserved in bacteria
QR42_09695	COG2755	lipolytic protein G-D-S-L family
QR42_09700	COG1999	signal sequence binding
QR42_09715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
QR42_09720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
QR42_09725	COG1272	protein, Hemolysin III
QR42_09730	COG0204	Acyl-transferase
QR42_09735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
QR42_09740	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
QR42_09745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
QR42_09755	COG2136	Putative SAM-dependent methyltransferase
QR42_09755	COG2521	methyltransferase
QR42_09765	COG0129	dihydroxy-acid dehydratase activity
QR42_09770	COG1413	lyase activity
QR42_09775	COG1418	mRNA catabolic process
QR42_09780	COG0386	Belongs to the glutathione peroxidase family
QR42_09785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
QR42_09790	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
QR42_09795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
QR42_09805	COG1278	Cold shock
QR42_09820	COG0328	RNA-DNA hybrid ribonuclease activity
QR42_09825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
QR42_09830	COG0328	RNA-DNA hybrid ribonuclease activity
QR42_09840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
QR42_09850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
QR42_09855	COG1755	Isoprenylcysteine carboxyl methyltransferase
QR42_09860	COG3424	synthase
QR42_09865	COG0726	polysaccharide deacetylase
QR42_09870	COG2233	PERMEase
QR42_09875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
QR42_09880	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
QR42_09885	COG1199	ATP-dependent helicase activity
QR42_09895	COG0116	Belongs to the methyltransferase superfamily
QR42_09900	COG3599	regulation of cell shape
QR42_09905	COG4474	Belongs to the UPF0398 family
QR42_09910	COG3359	exonuclease
QR42_09915	COG1205	dead DEAH box helicase
QR42_09915	COG1111	helicase
QR42_09920	COG1902	pentaerythritol trinitrate reductase activity
QR42_09925	COG2190	(PTS) system
QR42_09930	COG0071	Belongs to the small heat shock protein (HSP20) family
QR42_09960	COG3331	DNA recombination
QR42_09965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QR42_09965	COG4499	WXG100 protein secretion system (Wss), protein YukC
QR42_09975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
QR42_09980	COG3935	DnaD domain protein
QR42_09985	COG0017	Asparaginyl-tRNA synthetase
QR42_09990	COG5353	protein conserved in bacteria
QR42_09995	COG1199	ATP-dependent helicase activity
QR42_09995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
QR42_10000	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
QR42_10005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
QR42_10010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
QR42_10020	COG0617	tRNA 3'-terminal CCA addition
QR42_10025	COG0438	transferase activity, transferring glycosyl groups
QR42_10030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
QR42_10035	COG1803	Methylglyoxal synthase
QR42_10040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
QR42_10045	COG1694	Mazg nucleotide pyrophosphohydrolase
QR42_10050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QR42_10060	COG4347	Protein of unknown function (DUF1405)
QR42_10065	COG2010	Cytochrome c
QR42_10065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
QR42_10070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
QR42_10075	COG0723	plastoquinol--plastocyanin reductase activity
QR42_10085	COG5582	Belongs to the UPF0302 family
QR42_10090	COG0457	Tetratricopeptide repeat
QR42_10095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
QR42_10100	COG0287	Prephenate dehydrogenase
QR42_10105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
QR42_10110	COG0159	tryptophan synthase activity
QR42_10115	COG0133	tryptophan synthase activity
QR42_10120	COG0135	phosphoribosylanthranilate isomerase activity
QR42_10125	COG0134	indole-3-glycerol-phosphate synthase activity
QR42_10140	COG4401	Chorismate mutase type I
QR42_10145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
QR42_10150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
QR42_10155	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
QR42_10160	COG0105	UTP biosynthetic process
QR42_10165	COG0142	geranyltranstransferase activity
QR42_10170	COG2226	methyltransferase
QR42_10175	COG0142	geranyltranstransferase activity
QR42_10185	COG0302	gtp cyclohydrolase
QR42_10190	COG0776	regulation of translation
QR42_10195	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
QR42_10210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
QR42_10215	COG1160	GTP binding
QR42_10235	COG1304	FMN binding
QR42_10240	COG0539	negative regulation of cytoplasmic translation
QR42_10245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
QR42_10255	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
QR42_10260	COG2959	enzyme of heme biosynthesis
QR42_10265	COG3409	Peptidoglycan-binding domain 1 protein
QR42_10265	COG3773	Cell wall hydrolase
QR42_10270	COG2339	peptidase activity
QR42_10275	COG0492	ferredoxin-NADP+ reductase activity
QR42_10280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
QR42_10285	COG4862	establishment of competence for transformation
QR42_10290	COG1408	metallophosphoesterase
QR42_10300	COG1388	LysM domain
QR42_10305	COG1266	CAAX protease self-immunity
QR42_10310	COG0514	ATP-dependent DNA helicase (RecQ)
QR42_10315	COG4955	Helix-turn-helix domain
QR42_10320	COG1141	Ferredoxin
QR42_10325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
QR42_10330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
QR42_10335	COG0791	NLP P60 protein
QR42_10335	COG1388	LysM domain
QR42_10345	COG1595	DNA-templated transcription, initiation
QR42_10350	COG5002	protein histidine kinase activity
QR42_10355	COG0745	RESPONSE REGULATOR receiver
QR42_10360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
QR42_10365	COG1333	cytochrome c biogenesis protein
QR42_10370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_10375	COG1187	pseudouridine synthase activity
QR42_10380	COG0700	Nucleoside recognition
QR42_10385	COG2715	membrane protein required for spore maturation
QR42_10390	COG1686	Belongs to the peptidase S11 family
QR42_10400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
QR42_10405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
QR42_10410	COG1547	Domain of unknown function (DUF309)
QR42_10415	COG0456	acetyltransferase
QR42_10420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
QR42_10430	COG0307	riboflavin synthase, alpha
QR42_10445	COG1309	transcriptional regulator
QR42_10455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
QR42_10460	COG4086	secreted protein
QR42_10465	COG0019	diaminopimelate decarboxylase activity
QR42_10470	COG0697	spore germination
QR42_10485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
QR42_10505	COG1191	sigma factor activity
QR42_10510	COG2172	sigma factor antagonist activity
QR42_10520	COG1686	Belongs to the peptidase S11 family
QR42_10525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
QR42_10530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
QR42_10535	COG4974	Belongs to the 'phage' integrase family
QR42_10545	COG0735	belongs to the Fur family
QR42_10550	COG1300	Membrane
QR42_10555	COG1404	Belongs to the peptidase S8 family
QR42_10565	COG2153	protein acetylation
QR42_10570	COG1379	DNA repair
QR42_10575	COG0494	nUDIX hydrolase
QR42_10580	COG0667	Aldo Keto reductase
QR42_10595	COG1073	alpha beta
QR42_10600	COG0457	Tetratricopeptide repeat
QR42_10615	COG4918	Iron-sulphur cluster biosynthesis
QR42_10620	COG0456	acetyltransferase
QR42_10620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
QR42_10625	COG0456	acetyltransferase
QR42_10635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
QR42_10645	COG2211	Major facilitator Superfamily
QR42_10650	COG1072	(Pantothenic acid kinase))
QR42_10655	COG0446	pyridine nucleotide-disulphide oxidoreductase
QR42_10660	COG0300	oxidoreductase activity
QR42_10665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QR42_10670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
QR42_10680	COG4187	Peptidase family M20/M25/M40
QR42_10685	COG1902	pentaerythritol trinitrate reductase activity
QR42_10690	COG0596	Alpha beta hydrolase
QR42_10695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QR42_10705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
QR42_10710	COG2188	Transcriptional regulator
QR42_10715	COG2723	6-phospho-beta-galactosidase activity
QR42_10720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QR42_10725	COG1447	Phosphotransferase system cellobiose-specific component IIA
QR42_10730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QR42_10735	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_10745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
QR42_10750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
QR42_10765	COG0706	membrane insertase activity
QR42_10775	COG2195	Cleaves the N-terminal amino acid of tripeptides
QR42_10780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
QR42_10785	COG0346	lactoylglutathione lyase activity
QR42_10790	COG1376	ErfK ybiS ycfS ynhG family protein
QR42_10795	COG4129	membrane
QR42_10800	COG1126	abc transporter atp-binding protein
QR42_10805	COG0765	amino acid transport
QR42_10810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_10820	COG1597	lipid kinase activity
QR42_10830	COG0508	dehydrogenase complex catalyzes the overall conversion of
QR42_10835	COG0022	dehydrogenase e1 component
QR42_10840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
QR42_10845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
QR42_10850	COG3426	butyrate kinase activity
QR42_10855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
QR42_10860	COG0280	phosphate acetyltransferase
QR42_10865	COG3829	transcription factor binding
QR42_10865	COG3290	protein histidine kinase activity
QR42_10875	COG0584	glycerophosphoryl diester phosphodiesterase
QR42_10880	COG0457	Tetratricopeptide repeat
QR42_10890	COG0745	RESPONSE REGULATOR receiver
QR42_10895	COG0750	zinc metalloprotease
QR42_10900	COG0497	DNA recombination
QR42_10905	COG1438	arginine binding
QR42_10910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
QR42_10915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
QR42_10920	COG0142	geranyltranstransferase activity
QR42_10925	COG1722	exodeoxyribonuclease VII activity
QR42_10930	COG1570	exodeoxyribonuclease VII activity
QR42_10935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
QR42_10940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
QR42_10945	COG1302	Protein conserved in bacteria
QR42_10950	COG0439	Biotin carboxylase
QR42_10955	COG0511	ligase activity, forming carbon-carbon bonds
QR42_10995	COG3854	ATPases associated with a variety of cellular activities
QR42_11005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
QR42_11010	COG0006	proline dipeptidase activity
QR42_11015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
QR42_11025	COG3872	metal-dependent enzyme
QR42_11035	COG1752	Esterase of the alpha-beta hydrolase superfamily
QR42_11040	COG1321	iron dependent repressor
QR42_11045	COG0095	Lipoate-protein ligase
QR42_11050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QR42_11055	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
QR42_11060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
QR42_11065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
QR42_11070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
QR42_11090	COG0681	Belongs to the peptidase S26 family
QR42_11125	COG4970	Tfp pilus assembly protein FimT
QR42_11130	COG4537	Required for transformation and DNA binding
QR42_11135	COG1459	type II secretion system
QR42_11140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
QR42_11145	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_11155	COG1393	Belongs to the ArsC family
QR42_11165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QR42_11175	COG0011	TIGRFAM Protein of
QR42_11180	COG2814	Major facilitator Superfamily
QR42_11185	COG2866	Carboxypeptidase
QR42_11190	COG1368	sulfuric ester hydrolase activity
QR42_11195	COG1940	carbohydrate kinase activity
QR42_11200	COG4483	Protein conserved in bacteria
QR42_11205	COG0457	Tetratricopeptide repeat
QR42_11205	COG0705	Rhomboid family
QR42_11215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
QR42_11220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
QR42_11230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
QR42_11235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
QR42_11240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
QR42_11245	COG0581	inorganic phosphate transmembrane transporter activity
QR42_11250	COG0573	inorganic phosphate transmembrane transporter activity
QR42_11255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
QR42_11265	COG0477	Major facilitator Superfamily
QR42_11270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
QR42_11275	COG2839	Protein conserved in bacteria
QR42_11280	COG5521	maltodextrose utilization protein MalA
QR42_11285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QR42_11290	COG1388	LysM domain
QR42_11295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
QR42_11300	COG4709	membrane
QR42_11305	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
QR42_11310	COG1940	carbohydrate kinase activity
QR42_11315	COG0735	belongs to the Fur family
QR42_11320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
QR42_11325	COG1121	(ABC) transporter
QR42_11330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QR42_11345	COG0513	Belongs to the DEAD box helicase family
QR42_11355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
QR42_11360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
QR42_11365	COG2384	SAM-dependent methyltransferase
QR42_11370	COG2010	Cytochrome c
QR42_11375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
QR42_11380	COG0358	DNA primase activity
QR42_11385	COG1671	Belongs to the UPF0178 family
QR42_11390	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
QR42_11395	COG0517	IMP dehydrogenase activity
QR42_11400	COG0751	glycine-tRNA ligase activity
QR42_11405	COG0752	glycyl-tRNA synthetase alpha subunit
QR42_11410	COG1381	Involved in DNA repair and RecF pathway recombination
QR42_11415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
QR42_11420	COG0295	cytidine deaminase activity
QR42_11425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
QR42_11430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
QR42_11435	COG1480	7TM receptor with intracellular HD hydrolase
QR42_11440	COG1702	phosphate starvation-inducible protein PhoH
QR42_11445	COG0561	phosphatase activity
QR42_11460	COG4864	UPF0365 protein
QR42_11465	COG1030	water channel activity
QR42_11470	COG1610	YqeY-like protein
QR42_11475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
QR42_11480	COG1283	sodium-dependent phosphate transmembrane transporter activity
QR42_11485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
QR42_11490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
QR42_11495	COG2264	protein methyltransferase activity
QR42_11500	COG0484	heat shock protein binding
QR42_11505	COG0443	Heat shock 70 kDa protein
QR42_11510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
QR42_11515	COG1420	regulation of RNA biosynthetic process
QR42_11520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
QR42_11525	COG0481	GTPase activity
QR42_11535	COG0860	N-Acetylmuramoyl-L-alanine amidase
QR42_11540	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
QR42_11545	COG0268	Binds directly to 16S ribosomal RNA
QR42_11550	COG1466	dna polymerase III delta subunit
QR42_11560	COG2333	competence protein COMEC
QR42_11560	COG0658	competence protein
QR42_11565	COG2131	deaminase
QR42_11570	COG1555	photosystem II stabilization
QR42_11575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
QR42_11580	COG2226	methyltransferase
QR42_11585	COG0799	negative regulation of ribosome biogenesis
QR42_11590	COG1713	HD superfamily hydrolase involved in NAD metabolism
QR42_11595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
QR42_11600	COG1534	Rna-binding protein
QR42_11605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
QR42_11610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
QR42_11615	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
QR42_11625	COG2755	lipolytic protein G-D-S-L family
QR42_11635	COG0457	Tetratricopeptide repeat
QR42_11670	COG0726	polysaccharide deacetylase
QR42_11700	COG2160	L-arabinose isomerase activity
QR42_11715	COG1609	Transcriptional regulator
QR42_11735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
QR42_11740	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
QR42_11745	COG1733	regulation of RNA biosynthetic process
QR42_11880	COG1309	transcriptional regulator
QR42_11885	COG0109	protoheme IX farnesyltransferase activity
QR42_11890	COG2602	Beta-lactamase
QR42_11895	COG1960	acyl-CoA dehydrogenase activity
QR42_11900	COG1126	abc transporter atp-binding protein
QR42_11905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_11910	COG0765	amino acid transport
QR42_11920	COG3546	catalase activity
QR42_11925	COG1063	alcohol dehydrogenase
QR42_11935	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_11940	COG2226	methyltransferase
QR42_11945	COG1063	alcohol dehydrogenase
QR42_11950	COG2226	methyltransferase
QR42_11960	COG0626	cystathionine gamma-synthase activity
QR42_11965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
QR42_11970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
QR42_11975	COG2226	methyltransferase
QR42_11990	COG0768	penicillin binding
QR42_11995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
QR42_12005	COG0572	uridine kinase
QR42_12025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
QR42_12030	COG0183	Belongs to the thiolase family
QR42_12035	COG0318	PFAM AMP-dependent synthetase and ligase
QR42_12040	COG1268	BioY protein
QR42_12045	COG3906	Belongs to the UPF0473 family
QR42_12050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
QR42_12055	COG4472	Bacterial protein of unknown function (DUF965)
QR42_12060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
QR42_12065	COG0628	permease
QR42_12070	COG1126	abc transporter atp-binding protein
QR42_12075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_12080	COG0765	amino acid transport
QR42_12085	COG0765	amino acid transport
QR42_12095	COG3881	PFAM PRC-barrel domain
QR42_12100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
QR42_12105	COG0457	Tetratricopeptide repeat
QR42_12110	COG0482	sulfurtransferase activity
QR42_12115	COG1104	cysteine desulfurase activity
QR42_12120	COG1959	2 iron, 2 sulfur cluster binding
QR42_12125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
QR42_12130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
QR42_12140	COG0124	histidyl-tRNA synthetase
QR42_12145	COG0860	N-Acetylmuramoyl-L-alanine amidase
QR42_12145	COG4991	sh3 domain protein
QR42_12145	COG3103	Sh3 type 3 domain protein
QR42_12150	COG1490	D-aminoacyl-tRNA deacylase activity
QR42_12155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
QR42_12160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
QR42_12165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
QR42_12165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
QR42_12170	COG5416	Lipopolysaccharide assembly protein A domain
QR42_12175	COG0490	domain, Protein
QR42_12180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
QR42_12180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
QR42_12190	COG2244	polysaccharide biosynthetic process
QR42_12195	COG2323	membrane
QR42_12205	COG1862	Preprotein translocase
QR42_12210	COG0343	queuine tRNA-ribosyltransferase activity
QR42_12215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
QR42_12225	COG2255	four-way junction helicase activity
QR42_12230	COG0632	four-way junction helicase activity
QR42_12240	COG2112	serine threonine protein kinase
QR42_12250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
QR42_12265	COG1388	LysM domain
QR42_12265	COG1388	LysM domain
QR42_12270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
QR42_12275	COG0157	Belongs to the NadC ModD family
QR42_12280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
QR42_12285	COG1104	cysteine desulfurase activity
QR42_12290	COG1827	regulation of RNA biosynthetic process
QR42_12295	COG0077	Prephenate dehydratase
QR42_12300	COG4492	Belongs to the UPF0735 family
QR42_12305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
QR42_12310	COG3290	protein histidine kinase activity
QR42_12315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
QR42_12320	COG2868	ribosomal protein
QR42_12325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
QR42_12330	COG1994	Peptidase M50
QR42_12335	COG0739	heme binding
QR42_12340	COG2894	cell division
QR42_12345	COG0850	regulation of cytokinetic process
QR42_12350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
QR42_12355	COG1792	Involved in formation and maintenance of cell shape
QR42_12360	COG1077	Cell shape determining protein MreB Mrl
QR42_12365	COG2003	Belongs to the UPF0758 family
QR42_12370	COG0424	maF-like protein
QR42_12380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
QR42_12385	COG0285	dihydrofolate synthase activity
QR42_12390	COG0525	valine-tRNA ligase activity
QR42_12400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QR42_12405	COG1388	LysM domain
QR42_12410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
QR42_12415	COG0113	porphobilinogen synthase activity
QR42_12420	COG1587	Uroporphyrinogen-III synthase
QR42_12425	COG0181	hydroxymethylbilane synthase activity
QR42_12430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
QR42_12435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
QR42_12445	COG0218	Necessary for normal cell division and for the maintenance of normal septation
QR42_12450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
QR42_12455	COG1067	ATP-dependent peptidase activity
QR42_12455	COG0470	DNA polymerase III
QR42_12460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
QR42_12465	COG0544	peptidyl-prolyl cis-trans isomerase activity
QR42_12470	COG0457	Tetratricopeptide repeat
QR42_12470	COG1477	protein flavinylation
QR42_12475	COG0066	3-isopropylmalate dehydratase activity
QR42_12480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
QR42_12485	COG0473	3-isopropylmalate dehydrogenase activity
QR42_12490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
QR42_12495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
QR42_12500	COG0440	acetolactate synthase activity
QR42_12505	COG0028	Belongs to the TPP enzyme family
QR42_12510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QR42_12515	COG2706	6-phosphogluconolactonase activity
QR42_12520	COG3339	Conserved Protein
QR42_12525	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
QR42_12530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QR42_12535	COG1696	Membrane protein involved in D-alanine export
QR42_12540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QR42_12555	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_12565	COG0622	Phosphoesterase
QR42_12570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
QR42_12575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
QR42_12580	COG5401	PFAM Sporulation and spore germination
QR42_12585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
QR42_12590	COG1846	Transcriptional regulator
QR42_12595	COG2197	response regulator
QR42_12600	COG2851	Citrate transporter
QR42_12605	COG0583	DNA-binding transcription factor activity
QR42_12610	COG2828	Protein conserved in bacteria
QR42_12620	COG0824	Thioesterase
QR42_12625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
QR42_12630	COG1053	succinate dehydrogenase
QR42_12635	COG2009	succinate dehydrogenase
QR42_12640	COG1719	4-vinyl reductase, 4VR
QR42_12645	COG0527	aspartate kinase activity
QR42_12650	COG0322	excinuclease ABC activity
QR42_12655	COG3118	belongs to the thioredoxin family
QR42_12660	COG3534	alpha-L-arabinofuranosidase
QR42_12665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
QR42_12670	COG2086	electron transfer activity
QR42_12675	COG1024	Enoyl-CoA hydratase
QR42_12680	COG1309	transcriptional regulator
QR42_12685	COG0318	PFAM AMP-dependent synthetase and ligase
QR42_12695	COG3766	membrane
QR42_12700	COG1193	negative regulation of DNA recombination
QR42_12705	COG1796	DNA polymerase
QR42_12705	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
QR42_12710	COG1286	toxin biosynthetic process
QR42_12715	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
QR42_12720	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
QR42_12725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QR42_12725	COG0072	phenylalanine-tRNA ligase activity
QR42_12730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
QR42_12735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
QR42_12745	COG1966	Carbon starvation protein
QR42_12750	COG1363	Peptidase, m42
QR42_12760	COG3326	Membrane
QR42_12765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
QR42_12770	COG0291	Belongs to the bacterial ribosomal protein bL35 family
QR42_12775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
QR42_12780	COG1346	cytolysis
QR42_12790	COG3279	Response regulator of the LytR AlgR family
QR42_12795	COG3275	phosphorelay sensor kinase activity
QR42_12810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
QR42_12820	COG0398	Pfam SNARE associated Golgi protein
QR42_12825	COG1484	DNA-dependent DNA replication
QR42_12830	COG3611	Membrane attachment protein
QR42_12835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
QR42_12845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
QR42_12850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
QR42_12855	COG0237	dephospho-CoA kinase activity
QR42_12860	COG1971	Probably functions as a manganese efflux pump
QR42_12865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
QR42_12870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
QR42_12870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
QR42_12875	COG5002	protein histidine kinase activity
QR42_12880	COG0745	RESPONSE REGULATOR receiver
QR42_12885	COG0039	L-malate dehydrogenase activity
QR42_12890	COG0538	isocitrate dehydrogenase activity
QR42_12895	COG0372	Belongs to the citrate synthase family
QR42_12900	COG2707	UPF0756 membrane protein
QR42_12905	COG0628	permease
QR42_12910	COG3030	protein affecting phage T7 exclusion by the F plasmid
QR42_12920	COG0205	6-phosphofructokinase activity
QR42_12925	COG0825	malonyl-CoA metabolic process
QR42_12930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
QR42_12935	COG0281	malic enzyme
QR42_12940	COG0587	DNA-directed DNA polymerase activity
QR42_12960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
QR42_12970	COG4109	DRTGG domain
QR42_12975	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
QR42_12980	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_12990	COG0165	Argininosuccinate lyase
QR42_12995	COG0137	argininosuccinate synthase activity
QR42_13000	COG0521	Mo-molybdopterin cofactor biosynthetic process
QR42_13005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
QR42_13010	COG0827	DNA restriction-modification system
QR42_13015	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
QR42_13020	COG3874	Sporulation protein YtfJ
QR42_13030	COG1714	RDD family
QR42_13035	COG0616	signal peptide processing
QR42_13040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
QR42_13050	COG3239	Fatty acid desaturase
QR42_13055	COG4585	Histidine kinase
QR42_13060	COG2197	response regulator
QR42_13065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_13070	COG0745	RESPONSE REGULATOR receiver
QR42_13075	COG0642	Histidine kinase
QR42_13080	COG1136	(ABC) transporter
QR42_13085	COG0577	efflux transmembrane transporter activity
QR42_13090	COG0402	S-adenosylhomocysteine deaminase activity
QR42_13095	COG2249	NAD(P)H dehydrogenase (quinone) activity
QR42_13110	COG1279	arginine transmembrane transporter activity
QR42_13115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
QR42_13125	COG0301	tRNA thio-modification
QR42_13130	COG1104	cysteine desulfurase activity
QR42_13135	COG1114	Component of the transport system for branched-chain amino acids
QR42_13140	COG1114	Component of the transport system for branched-chain amino acids
QR42_13145	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
QR42_13150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
QR42_13155	COG1309	transcriptional regulator
QR42_13160	COG1956	GAF domain-containing protein
QR42_13165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
QR42_13175	COG1335	isochorismatase
QR42_13180	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
QR42_13185	COG2329	Antibiotic biosynthesis monooxygenase
QR42_13190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
QR42_13195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
QR42_13200	COG0454	-acetyltransferase
QR42_13205	COG0517	IMP dehydrogenase activity
QR42_13210	COG0123	including yeast histone deacetylase and acetoin utilization protein
QR42_13215	COG1609	Transcriptional regulator
QR42_13220	COG1605	Chorismate mutase
QR42_13220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
QR42_13225	COG3118	belongs to the thioredoxin family
QR42_13230	COG4980	gas vesicle protein
QR42_13235	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
QR42_13240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
QR42_13245	COG1674	ftsk spoiiie
QR42_13250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QR42_13255	COG4848	Belongs to the UPF0354 family
QR42_13260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_13275	COG1363	Peptidase, m42
QR42_13280	COG5584	Small secreted protein
QR42_13285	COG0281	malic enzyme
QR42_13290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QR42_13295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
QR42_13305	COG0510	thiamine kinase activity
QR42_13315	COG1597	lipid kinase activity
QR42_13325	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
QR42_13330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
QR42_13340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
QR42_13345	COG2252	PERMEase
QR42_13350	COG1349	DNA-binding transcription factor activity
QR42_13355	COG1187	pseudouridine synthase activity
QR42_13360	COG2244	polysaccharide biosynthetic process
QR42_13365	COG2081	HI0933 family
QR42_13375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
QR42_13380	COG3196	Protein conserved in bacteria
QR42_13390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QR42_13395	COG5578	integral membrane protein
QR42_13400	COG0673	inositol 2-dehydrogenase activity
QR42_13405	COG1653	transport
QR42_13410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
QR42_13415	COG4209	transmembrane transport
QR42_13420	COG2207	Transcriptional regulator
QR42_13425	COG1733	regulation of RNA biosynthetic process
QR42_13430	COG2814	Major facilitator Superfamily
QR42_13435	COG0656	L-ascorbic acid biosynthetic process
QR42_13440	COG1653	transport
QR42_13445	COG0395	ABC-type sugar transport system, permease component
QR42_13450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
QR42_13455	COG1073	alpha beta
QR42_13460	COG0495	leucyl-tRNA aminoacylation
QR42_13470	COG2202	Pas domain
QR42_13470	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_13475	COG2433	Pfam Transposase IS66
QR42_13480	COG0577	efflux transmembrane transporter activity
QR42_13485	COG1136	(ABC) transporter
QR42_13495	COG1131	(ABC) transporter
QR42_13500	COG1725	Transcriptional regulator
QR42_13535	COG1242	4 iron, 4 sulfur cluster binding
QR42_13540	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
QR42_13550	COG2267	carboxylic ester hydrolase activity
QR42_13555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
QR42_13560	COG0367	asparagine synthase
QR42_13565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
QR42_13570	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
QR42_13580	COG1506	peptidase
QR42_13585	COG1233	COG1233 Phytoene dehydrogenase and related
QR42_13605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
QR42_13610	COG1116	anion transmembrane transporter activity
QR42_13615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
QR42_13620	COG0494	nUDIX hydrolase
QR42_13625	COG2310	stress, protein
QR42_13640	COG4824	toxin secretion phage lysis holin
QR42_13650	COG0783	Belongs to the Dps family
QR42_13665	COG1854	S-ribosylhomocysteine lyase activity
QR42_13670	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
QR42_13675	COG0288	reversible hydration of carbon dioxide
QR42_13680	COG0803	Belongs to the bacterial solute-binding protein 9 family
QR42_13680	COG3443	Belongs to the bacterial solute-binding protein 9 family
QR42_13685	COG0254	rRNA binding
QR42_13690	COG1271	oxidase subunit
QR42_13695	COG1294	oxidase, subunit
QR42_13710	COG4948	Mandelate Racemase Muconate Lactonizing
QR42_13715	COG0318	PFAM AMP-dependent synthetase and ligase
QR42_13720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
QR42_13725	COG0596	Alpha beta hydrolase
QR42_13730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
QR42_13735	COG1169	isochorismate synthase
QR42_13740	COG1575	Belongs to the MenA family. Type 1 subfamily
QR42_13745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
QR42_13875	COG3859	Proton-coupled thiamine transporter YuaJ
QR42_13885	COG1247	-acetyltransferase
QR42_13890	COG2268	Band 7 protein
QR42_13895	COG1585	Membrane protein implicated in regulation of membrane protease activity
QR42_13900	COG2318	DinB family
QR42_13905	COG1454	alcohol dehydrogenase
QR42_13915	COG1510	regulation of RNA biosynthetic process
QR42_13930	COG5632	N-Acetylmuramoyl-L-alanine amidase
QR42_13930	COG3409	Peptidoglycan-binding domain 1 protein
QR42_13980	COG3778	Protein conserved in bacteria
QR42_13985	COG3299	homolog of phage Mu protein gp47
QR42_13990	COG3628	GPW Gp25 family protein
QR42_14000	COG4193	domain, Protein
QR42_14005	COG1652	LysM domain
QR42_14010	COG5280	Phage tail tape measure protein TP901
QR42_14010	COG5280	Phage tail tape measure protein TP901
QR42_14010	COG3953	SLT domain
QR42_14010	COG3953	SLT domain
QR42_14060	COG4653	Phage capsid family
QR42_14065	COG0338	D12 class N6 adenine-specific DNA methyltransferase
QR42_14070	COG5518	Phage portal protein
QR42_14075	COG1783	phage Terminase large subunit
QR42_14080	COG5484	DNA packaging
QR42_14085	COG1595	DNA-templated transcription, initiation
QR42_14095	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
QR42_14110	COG1396	sequence-specific DNA binding
QR42_14120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
QR42_14135	COG0628	permease
QR42_14145	COG0673	inositol 2-dehydrogenase activity
QR42_14150	COG0693	protein deglycase activity
QR42_14155	COG0840	transmembrane signaling receptor activity
QR42_14160	COG0840	transmembrane signaling receptor activity
QR42_14165	COG0840	transmembrane signaling receptor activity
QR42_14170	COG0840	transmembrane signaling receptor activity
QR42_14185	COG2070	2-Nitropropane dioxygenase
QR42_14190	COG0432	Pfam Uncharacterised protein family UPF0047
QR42_14195	COG1253	flavin adenine dinucleotide binding
QR42_14200	COG2738	Putative neutral zinc metallopeptidase
QR42_14210	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
QR42_14225	COG0166	Belongs to the GPI family
QR42_14230	COG1979	alcohol dehydrogenase
QR42_14235	COG1979	alcohol dehydrogenase
QR42_14240	COG2155	Conserved Protein
QR42_14245	COG1098	S1 RNA binding domain
QR42_14250	COG0436	Aminotransferase
QR42_14255	COG1522	sequence-specific DNA binding
QR42_14260	COG2267	carboxylic ester hydrolase activity
QR42_14270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
QR42_14275	COG2205	protein histidine kinase activity
QR42_14285	COG5018	Exonuclease
QR42_14290	COG2814	Major facilitator Superfamily
QR42_14295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QR42_14300	COG3011	Protein conserved in bacteria
QR42_14310	COG3290	protein histidine kinase activity
QR42_14315	COG4565	transcriptional regulatory protein
QR42_14340	COG3493	citrate carrier protein
QR42_14350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
QR42_14350	COG2111	Na H antiporter
QR42_14355	COG2111	Na H antiporter
QR42_14360	COG1006	Multisubunit Na H antiporter MnhC subunit
QR42_14365	COG0651	ATP synthesis coupled electron transport
QR42_14370	COG1863	multisubunit Na H antiporter MnhE subunit
QR42_14375	COG2212	antiporter activity
QR42_14380	COG1320	monovalent cation:proton antiporter activity
QR42_14385	COG2050	protein possibly involved in aromatic compounds catabolism
QR42_14390	COG2197	response regulator
QR42_14395	COG4585	Histidine kinase
QR42_14405	COG0142	geranyltranstransferase activity
QR42_14420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
QR42_14425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
QR42_14430	COG1335	isochorismatase
QR42_14435	COG5506	Protein of unknown function (DUF1694)
QR42_14455	COG0628	permease
QR42_14470	COG1418	mRNA catabolic process
QR42_14475	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_14485	COG1511	domain protein
QR42_14490	COG1674	ftsk spoiiie
QR42_14490	COG0433	COG0433 Predicted ATPase
QR42_14495	COG4499	WXG100 protein secretion system (Wss), protein YukC
QR42_14500	COG5417	Belongs to the EsaB family
QR42_14505	COG4842	Belongs to the WXG100 family
QR42_14510	COG2508	Transcriptional regulator
QR42_14510	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
QR42_14515	COG0686	Belongs to the AlaDH PNT family
QR42_14520	COG1268	BioY protein
QR42_14525	COG4326	sporulation control protein
QR42_14530	COG2056	Na+-H+ antiporter family
QR42_14535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
QR42_14540	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
QR42_14545	COG3584	3D domain protein
QR42_14555	COG1252	NADH dehydrogenase
QR42_14560	COG0492	ferredoxin-NADP+ reductase activity
QR42_14570	COG0789	Transcriptional regulator
QR42_14575	COG0316	Belongs to the HesB IscA family
QR42_14580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
QR42_14585	COG4844	belongs to the
QR42_14590	COG1252	NADH dehydrogenase
QR42_14600	COG4837	Protein of unknown function (DUF1462)
QR42_14605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
QR42_14610	COG4946	Tricorn protease homolog
QR42_14610	COG0823	Involved in the tonB-independent uptake of proteins
QR42_14610	COG1506	peptidase
QR42_14615	COG0083	homoserine kinase activity
QR42_14620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
QR42_14625	COG0460	homoserine dehydrogenase
QR42_14630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
QR42_14635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QR42_14640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
QR42_14645	COG0647	UMP catabolic process
QR42_14650	COG2445	Protein of unknown function DUF86
QR42_14655	COG4470	Protein conserved in bacteria
QR42_14665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
QR42_14670	COG0739	heme binding
QR42_14680	COG3377	Domain of unknown function (DUF1805)
QR42_14685	COG0737	Belongs to the 5'-nucleotidase family
QR42_14690	COG1801	Protein of unknown function DUF72
QR42_14695	COG2508	Transcriptional regulator
QR42_14700	COG2140	Oxalate decarboxylase
QR42_14710	COG2814	Major facilitator Superfamily
QR42_14715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
QR42_14720	COG2356	endonuclease I
QR42_14730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QR42_14735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QR42_14740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_14755	COG5002	protein histidine kinase activity
QR42_14755	COG0642	Histidine kinase
QR42_14760	COG0745	RESPONSE REGULATOR receiver
QR42_14765	COG2311	Membrane
QR42_14775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
QR42_14780	COG1090	epimerase
QR42_14815	COG0719	Fe-S assembly protein
QR42_14820	COG0822	iron-sulfur transferase activity
QR42_14825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
QR42_14830	COG0719	Fe-S assembly protein
QR42_14835	COG0396	ATPase activity
QR42_14840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
QR42_14845	COG1464	Belongs to the NlpA lipoprotein family
QR42_14850	COG2011	ABC-type metal ion transport system permease component
QR42_14855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
QR42_14865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_14870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
QR42_14880	COG0509	glycine decarboxylation via glycine cleavage system
QR42_14885	COG1393	Belongs to the ArsC family
QR42_14890	COG1960	acyl-CoA dehydrogenase activity
QR42_14895	COG0183	Belongs to the thiolase family
QR42_14900	COG1250	3-hydroxyacyl-CoA dehydrogenase
QR42_14900	COG1024	Enoyl-CoA hydratase
QR42_14910	COG5577	PFAM Coat F domain
QR42_14920	COG1120	ATPase activity
QR42_14930	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_14935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QR42_14940	COG0745	RESPONSE REGULATOR receiver
QR42_14945	COG2205	protein histidine kinase activity
QR42_14945	COG2770	Histidine kinase
QR42_14950	COG1309	transcriptional regulator
QR42_14955	COG0114	fumarate hydratase activity
QR42_14960	COG0697	spore germination
QR42_14965	COG0814	amino acid
QR42_14980	COG2197	response regulator
QR42_14985	COG4585	Histidine kinase
QR42_14990	COG4758	membrane
QR42_15000	COG1842	Phage shock protein A
QR42_15005	COG4758	membrane
QR42_15010	COG1917	Cupin 2, conserved barrel domain protein
QR42_15010	COG4977	sequence-specific DNA binding
QR42_15020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_15025	COG0492	ferredoxin-NADP+ reductase activity
QR42_15030	COG2096	Adenosyltransferase
QR42_15040	COG1120	ATPase activity
QR42_15045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QR42_15050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_15060	COG2721	sulfolactate sulfo-lyase activity
QR42_15065	COG0246	Mannitol dehydrogenase
QR42_15070	COG1609	Transcriptional regulator
QR42_15075	COG1904	glucuronate isomerase
QR42_15080	COG2205	protein histidine kinase activity
QR42_15085	COG0745	RESPONSE REGULATOR receiver
QR42_15090	COG1120	ATPase activity
QR42_15095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QR42_15100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QR42_15105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_15110	COG0531	amino acid
QR42_15125	COG1988	membrane-bound metal-dependent
QR42_15130	COG1368	sulfuric ester hydrolase activity
QR42_15135	COG0725	ABC transporter, periplasmic molybdate-binding protein
QR42_15140	COG4149	molybdate abc transporter
QR42_15145	COG0656	L-ascorbic acid biosynthetic process
QR42_15150	COG1940	carbohydrate kinase activity
QR42_15155	COG0025	NhaP-type Na H and K H
QR42_15160	COG2860	membrane
QR42_15165	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
QR42_15170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
QR42_15175	COG2217	Heavy metal translocating P-type atpase
QR42_15180	COG1121	(ABC) transporter
QR42_15185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
QR42_15190	COG0803	Belongs to the bacterial solute-binding protein 9 family
QR42_15200	COG3226	Transcriptional regulator
QR42_15205	COG0784	Response regulator, receiver
QR42_15210	COG4191	Histidine kinase
QR42_15215	COG1027	Aspartate ammonia-lyase
QR42_15225	COG2217	Heavy metal translocating P-type atpase
QR42_15230	COG2608	mercury ion transmembrane transporter activity
QR42_15235	COG1937	Protein conserved in bacteria
QR42_15245	COG0745	RESPONSE REGULATOR receiver
QR42_15245	COG3706	GGDEF domain
QR42_15275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
QR42_15280	COG0557	exoribonuclease II activity
QR42_15285	COG1647	Serine aminopeptidase, S33
QR42_15290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
QR42_15295	COG2002	toxin-antitoxin pair type II binding
QR42_15300	COG1476	TRANSCRIPTIONal
QR42_15305	COG1396	sequence-specific DNA binding
QR42_15310	COG1396	sequence-specific DNA binding
QR42_15315	COG1733	regulation of RNA biosynthetic process
QR42_15320	COG1174	glycine betaine transport
QR42_15325	COG1732	Glycine betaine
QR42_15330	COG1174	glycine betaine transport
QR42_15335	COG0517	IMP dehydrogenase activity
QR42_15335	COG1125	glycine betaine transport
QR42_15340	COG1510	regulation of RNA biosynthetic process
QR42_15345	COG2095	MarC family integral membrane protein
QR42_15355	COG0456	acetyltransferase
QR42_15375	COG4555	ABC transporter
QR42_15385	COG0148	phosphopyruvate hydratase activity
QR42_15390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
QR42_15395	COG0149	triose-phosphate isomerase activity
QR42_15400	COG0126	phosphoglycerate kinase activity
QR42_15405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
QR42_15410	COG2390	Transcriptional regulator
QR42_15420	COG0833	amino acid
QR42_15425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
QR42_15430	COG3829	transcription factor binding
QR42_15435	COG2186	Transcriptional regulator
QR42_15440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
QR42_15450	COG0534	Mate efflux family protein
QR42_15455	COG4608	Belongs to the ABC transporter superfamily
QR42_15460	COG0444	Belongs to the ABC transporter superfamily
QR42_15465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
QR42_15470	COG0601	transmembrane transport
QR42_15475	COG0747	negative chemotaxis
QR42_15480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
QR42_15485	COG0110	maltose O-acetyltransferase activity
QR42_15490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
QR42_15495	COG2244	polysaccharide biosynthetic process
QR42_15500	COG5039	Polysaccharide pyruvyl transferase
QR42_15505	COG1216	Glycosyl transferase, family 2
QR42_15515	COG0438	transferase activity, transferring glycosyl groups
QR42_15520	COG1215	transferase activity, transferring glycosyl groups
QR42_15525	COG0438	transferase activity, transferring glycosyl groups
QR42_15530	COG1086	Polysaccharide biosynthesis protein
QR42_15535	COG0489	protein tyrosine kinase activity
QR42_15540	COG3944	biosynthesis protein
QR42_15545	COG1396	sequence-specific DNA binding
QR42_15555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_15560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QR42_15565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QR42_15570	COG0726	polysaccharide deacetylase
QR42_15585	COG0444	Belongs to the ABC transporter superfamily
QR42_15595	COG0601	transmembrane transport
QR42_15600	COG0747	negative chemotaxis
QR42_15605	COG1819	glycosyl
QR42_15610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_15630	COG0740	serine-type endopeptidase activity
QR42_15635	COG1611	Belongs to the LOG family
QR42_15640	COG1694	Mazg nucleotide pyrophosphohydrolase
QR42_15645	COG0659	secondary active sulfate transmembrane transporter activity
QR42_15650	COG0288	reversible hydration of carbon dioxide
QR42_15655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
QR42_15665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
QR42_15670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_15675	COG1481	regulation of sporulation
QR42_15680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
QR42_15685	COG1660	Displays ATPase and GTPase activities
QR42_15690	COG1051	belongs to the nudix hydrolase family
QR42_15695	COG0492	ferredoxin-NADP+ reductase activity
QR42_15700	COG3883	PFAM NLP P60 protein
QR42_15700	COG0791	NLP P60 protein
QR42_15705	COG0457	Tetratricopeptide repeat
QR42_15710	COG0140	phosphoribosyl-ATP diphosphatase activity
QR42_15710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
QR42_15715	COG0107	imidazoleglycerol-phosphate synthase activity
QR42_15720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
QR42_15725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
QR42_15730	COG0131	Imidazoleglycerol-phosphate dehydratase
QR42_15735	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
QR42_15740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
QR42_15745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
QR42_15750	COG4990	cell redox homeostasis
QR42_15760	COG2910	NAD(P)H-binding
QR42_15765	COG1959	2 iron, 2 sulfur cluster binding
QR42_15770	COG0110	maltose O-acetyltransferase activity
QR42_15775	COG0546	phosphoglycolate phosphatase activity
QR42_15780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
QR42_15790	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
QR42_15795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
QR42_15800	COG0363	glucosamine-6-phosphate deaminase activity
QR42_15810	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
QR42_15815	COG1950	PFAM Membrane protein of
QR42_15820	COG1983	PspC domain protein
QR42_15825	COG3595	metallopeptidase activity
QR42_15840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
QR42_15850	COG4897	Protein conserved in bacteria
QR42_15860	COG3848	Pyruvate phosphate dikinase
QR42_15860	COG0574	Belongs to the PEP-utilizing enzyme family
QR42_15865	COG1309	transcriptional regulator
QR42_15870	COG2814	Major facilitator Superfamily
QR42_15880	COG0745	RESPONSE REGULATOR receiver
QR42_15885	COG5002	protein histidine kinase activity
QR42_15890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
QR42_15895	COG0463	Glycosyl transferase, family 2
QR42_15900	COG1113	amino acid transport
QR42_15905	COG0778	Nitroreductase
QR42_15910	COG1733	regulation of RNA biosynthetic process
QR42_15915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QR42_15925	COG3409	Peptidoglycan-binding domain 1 protein
QR42_15925	COG0793	Belongs to the peptidase S41A family
QR42_15930	COG0730	response to heat
QR42_15935	COG3883	PFAM NLP P60 protein
QR42_15935	COG0791	NLP P60 protein
QR42_15940	COG2177	Part of the ABC transporter FtsEX involved in
QR42_15945	COG2884	Cell division ATP-binding protein ftsE
QR42_15950	COG2010	Cytochrome c
QR42_15955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QR42_15970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
QR42_15975	COG0653	protein targeting
QR42_15980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
QR42_15985	COG0840	transmembrane signaling receptor activity
QR42_16000	COG1516	flagellar protein fliS
QR42_16005	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
QR42_16010	COG1334	flagellar protein FlaG
QR42_16015	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
QR42_16020	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
QR42_16030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
QR42_16035	COG1256	bacterial-type flagellum assembly
QR42_16035	COG4786	Flagellar basal body rod
QR42_16040	COG3418	PFAM FlgN family protein
QR42_16055	COG1040	competence protein
QR42_16065	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
QR42_16070	COG1307	EDD domain protein, DegV family
QR42_16075	COG2197	response regulator
QR42_16080	COG4585	Histidine kinase
QR42_16085	COG1739	Uncharacterized protein family UPF0029
QR42_16090	COG1316	TRANSCRIPTIONal
QR42_16095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
QR42_16100	COG0438	transferase activity, transferring glycosyl groups
QR42_16105	COG1215	transferase activity, transferring glycosyl groups
QR42_16110	COG3206	protein involved in exopolysaccharide biosynthesis
QR42_16115	COG3307	-O-antigen
QR42_16120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
QR42_16125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
QR42_16130	COG0438	transferase activity, transferring glycosyl groups
QR42_16130	COG0297	glycogen (starch) synthase activity
QR42_16135	COG2244	polysaccharide biosynthetic process
QR42_16150	COG2247	cell wall binding repeat
QR42_16150	COG0860	N-Acetylmuramoyl-L-alanine amidase
QR42_16155	COG2385	sporulation resulting in formation of a cellular spore
QR42_16155	COG2247	cell wall binding repeat
QR42_16165	COG1316	TRANSCRIPTIONal
QR42_16170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
QR42_16175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
QR42_16180	COG1134	teichoic acid transport
QR42_16185	COG1682	transport, permease protein
QR42_16190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
QR42_16225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
QR42_16235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
QR42_16240	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
QR42_16245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
QR42_16250	COG4193	domain, Protein
QR42_16255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
QR42_16255	COG0463	Glycosyl transferase, family 2
QR42_16260	COG1482	cell wall glycoprotein biosynthetic process
QR42_16270	COG1175	transmembrane transport
QR42_16275	COG1653	transport
QR42_16280	COG2197	response regulator
QR42_16285	COG2972	Histidine kinase
QR42_16295	COG0454	-acetyltransferase
QR42_16300	COG0800	Aldolase
QR42_16305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
QR42_16310	COG1609	Transcriptional regulator
QR42_16315	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
QR42_16320	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_16325	COG0697	spore germination
QR42_16330	COG0814	amino acid
QR42_16345	COG2814	Major facilitator Superfamily
QR42_16350	COG1316	TRANSCRIPTIONal
QR42_16355	COG0561	phosphatase activity
QR42_16360	COG0791	NLP P60 protein
QR42_16365	COG2843	Capsule synthesis protein
QR42_16375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
QR42_16380	COG0697	spore germination
QR42_16395	COG1609	Transcriptional regulator
QR42_16400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
QR42_16405	COG1869	D-ribose catabolic process
QR42_16410	COG1129	ABC transporter
QR42_16415	COG1172	Belongs to the binding-protein-dependent transport system permease family
QR42_16420	COG1879	ABC-type sugar transport system periplasmic component
QR42_16425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
QR42_16430	COG0583	DNA-binding transcription factor activity
QR42_16435	COG0028	Belongs to the TPP enzyme family
QR42_16440	COG3527	Alpha-acetolactate decarboxylase
QR42_16445	COG1522	sequence-specific DNA binding
QR42_16450	COG2059	Chromate
QR42_16455	COG2059	Chromate
QR42_16460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
QR42_16465	COG4715	Zinc finger, swim domain protein
QR42_16470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
QR42_16475	COG2202	Pas domain
QR42_16475	COG1366	Belongs to the anti-sigma-factor antagonist family
QR42_16480	COG0561	phosphatase activity
QR42_16495	COG1970	mechanosensitive ion channel activity
QR42_16500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
QR42_16505	COG0457	Tetratricopeptide repeat
QR42_16510	COG4786	Flagellar basal body rod
QR42_16515	COG4786	Flagellar basal body rod
QR42_16520	COG1077	Cell shape determining protein MreB Mrl
QR42_16525	COG1609	Transcriptional regulator
QR42_16530	COG1846	Transcriptional regulator
QR42_16535	COG2814	Major facilitator Superfamily
QR42_16540	COG0671	phosphoesterase, PA-phosphatase related
QR42_16545	COG0477	Major facilitator Superfamily
QR42_16550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_16565	COG0004	ammonium transporteR
QR42_16570	COG0347	Belongs to the P(II) protein family
QR42_16575	COG0739	heme binding
QR42_16580	COG1247	-acetyltransferase
QR42_16615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
QR42_16620	COG0523	cobalamin synthesis protein
QR42_16625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
QR42_16630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
QR42_16635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
QR42_16645	COG0243	molybdopterin cofactor binding
QR42_16650	COG2304	oxidoreductase activity
QR42_16655	COG2304	oxidoreductase activity
QR42_16660	COG2385	sporulation resulting in formation of a cellular spore
QR42_16665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
QR42_16675	COG4836	Membrane
QR42_16685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
QR42_16690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
QR42_16695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
QR42_16700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
QR42_16705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
QR42_16710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
QR42_16715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
QR42_16720	COG0356	it plays a direct role in the translocation of protons across the membrane
QR42_16735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
QR42_16740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
QR42_16745	COG4475	Protein of unknown function (DUF436)
QR42_16750	COG0698	ribose 5-phosphate isomerase
QR42_16755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
QR42_16760	COG1971	Probably functions as a manganese efflux pump
QR42_16765	COG0009	L-threonylcarbamoyladenylate synthase
QR42_16770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
QR42_16785	COG2890	protein-(glutamine-N5) methyltransferase activity
QR42_16790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
QR42_16795	COG0789	Transcriptional regulator
QR42_16800	COG0679	Auxin Efflux Carrier
QR42_16805	COG0281	malic enzyme
QR42_16810	COG1435	thymidine kinase activity
QR42_16815	COG0254	rRNA binding
QR42_16820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
QR42_16825	COG1494	fructose-1,6-bisphosphatase
QR42_16830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
QR42_16835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
QR42_16840	COG0191	fructose-bisphosphate aldolase activity
QR42_16845	COG2204	response regulator
QR42_16850	COG4821	SIS domain
QR42_16855	COG0504	CTP synthase activity
QR42_16860	COG3343	RNA polymerase activity
QR42_16870	COG1960	acyl-CoA dehydrogenase activity
QR42_16875	COG1960	acyl-CoA dehydrogenase activity
QR42_16880	COG1250	3-hydroxyacyl-CoA dehydrogenase
QR42_16885	COG0183	Belongs to the thiolase family
QR42_16890	COG0247	lactate metabolic process
QR42_16890	COG2181	nitrate reductase activity
QR42_16895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
QR42_16900	COG4294	response to UV
QR42_16910	COG1619	proteins homologs of microcin C7 resistance protein MccF
QR42_16920	COG1132	(ABC) transporter
QR42_16925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
QR42_16930	COG1619	proteins homologs of microcin C7 resistance protein MccF
QR42_16935	COG0018	arginyl-trna synthetase
QR42_16940	COG4506	Protein conserved in bacteria
QR42_16955	COG0010	Belongs to the arginase family
QR42_16960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
QR42_16965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QR42_16975	COG1994	Peptidase M50
QR42_16980	COG1942	4-Oxalocrotonate Tautomerase
QR42_16990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QR42_16995	COG0583	DNA-binding transcription factor activity
QR42_17000	COG0431	NADPH-dependent FMN reductase
QR42_17005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QR42_17010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
QR42_17015	COG0454	-acetyltransferase
QR42_17020	COG0765	amino acid transport
QR42_17025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_17035	COG1126	abc transporter atp-binding protein
QR42_17040	COG3465	dGTPase activity
QR42_17045	COG1078	dGTPase activity
QR42_17050	COG4844	belongs to the
QR42_17095	COG5444	nuclease activity
QR42_17125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
QR42_17135	COG0280	phosphate acetyltransferase
QR42_17145	COG2814	Major facilitator Superfamily
QR42_17150	COG1522	sequence-specific DNA binding
QR42_17155	COG2814	Major facilitator Superfamily
QR42_17160	COG0077	Prephenate dehydratase
QR42_17170	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_17175	COG0151	Belongs to the GarS family
QR42_17180	COG0436	Aminotransferase
QR42_17185	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_17190	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
QR42_17195	COG1091	dTDP-4-dehydrorhamnose reductase activity
QR42_17200	COG1088	dTDP-glucose 4,6-dehydratase activity
QR42_17205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
QR42_17210	COG3980	spore coat polysaccharide biosynthesis protein
QR42_17215	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
QR42_17220	COG2089	acid synthase
QR42_17225	COG0456	acetyltransferase
QR42_17230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
QR42_17235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
QR42_17240	COG0463	Glycosyl transferase, family 2
QR42_17260	COG2363	Small membrane protein
QR42_17265	COG2233	PERMEase
QR42_17275	COG1012	belongs to the aldehyde dehydrogenase family
QR42_17280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
QR42_17285	COG1216	Glycosyl transferase, family 2
QR42_17295	COG0351	phosphomethylpyrimidine kinase
QR42_17315	COG3964	amidohydrolase
QR42_17320	COG1621	beta-fructofuranosidase activity
QR42_17325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_17325	COG1263	PTS System
QR42_17330	COG3711	transcriptional antiterminator
QR42_17340	COG1404	Belongs to the peptidase S8 family
QR42_17345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QR42_17350	COG0778	Nitroreductase
QR42_17355	COG0772	Belongs to the SEDS family
QR42_17365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
QR42_17370	COG1845	cytochrome c oxidase, subunit III
QR42_17375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
QR42_17380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
QR42_17390	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
QR42_17395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
QR42_17400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
QR42_17415	COG2246	polysaccharide biosynthetic process
QR42_17435	COG3162	membrane
QR42_17440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QR42_17455	COG0352	thiamine-phosphate diphosphorylase activity
QR42_17460	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
QR42_17465	COG0583	DNA-binding transcription factor activity
QR42_17470	COG1380	Effector of murein hydrolase LrgA
QR42_17475	COG1346	cytolysis
QR42_17480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
QR42_17485	COG0346	lactoylglutathione lyase activity
QR42_17495	COG0765	amino acid transport
QR42_17500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QR42_17505	COG0457	Tetratricopeptide repeat
QR42_17510	COG2357	RelA SpoT domain protein
QR42_17515	COG1172	Belongs to the binding-protein-dependent transport system permease family
QR42_17520	COG1129	ABC transporter
QR42_17530	COG3420	alginic acid biosynthetic process
QR42_17535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QR42_17550	COG1486	melibiose metabolic process
QR42_17555	COG1447	Phosphotransferase system cellobiose-specific component IIA
QR42_17560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QR42_17565	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QR42_17570	COG3711	transcriptional antiterminator
QR42_17570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_17585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
QR42_17600	COG1595	DNA-templated transcription, initiation
QR42_17605	COG3866	Pectate lyase
QR42_17610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
QR42_17615	COG4988	ABC transporter
QR42_17620	COG1294	oxidase, subunit
QR42_17625	COG1271	oxidase subunit
QR42_17645	COG4509	Sortase family
QR42_17670	COG5386	Cell surface protein
QR42_17675	COG5386	Cell surface protein
QR42_17680	COG1733	regulation of RNA biosynthetic process
QR42_17685	COG2514	catechol 2,3-dioxygenase activity
QR42_17690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
QR42_17690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
QR42_17695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
QR42_17695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
QR42_17705	COG0726	polysaccharide deacetylase
QR42_17710	COG1447	Phosphotransferase system cellobiose-specific component IIA
QR42_17715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QR42_17720	COG2723	6-phospho-beta-galactosidase activity
QR42_17725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QR42_17730	COG3711	transcriptional antiterminator
QR42_17730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QR42_17755	COG1757	Na H antiporter
QR42_17760	COG1027	Aspartate ammonia-lyase
QR42_17765	COG0252	asparaginase activity
QR42_17770	COG1396	sequence-specific DNA binding
QR42_17795	COG4842	Belongs to the WXG100 family
QR42_17800	COG2195	Cleaves the N-terminal amino acid of tripeptides
QR42_17815	COG1737	Transcriptional regulator
QR42_17820	COG2084	Dehydrogenase
QR42_17830	COG2610	gluconate transmembrane transporter activity
QR42_17835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
QR42_17840	COG2723	6-phospho-beta-galactosidase activity
QR42_17845	COG2190	(PTS) system
QR42_17845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_17845	COG1263	PTS System
QR42_17850	COG3711	transcriptional antiterminator
QR42_17855	COG3878	Protein conserved in bacteria
QR42_17865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
QR42_17870	COG1122	ATPase activity
QR42_17875	COG4721	ABC-type cobalt transport system, permease component
QR42_17880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
QR42_17905	COG3291	Pkd domain containing protein
QR42_17905	COG4412	M6 family metalloprotease domain protein
QR42_17910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
QR42_17915	COG0778	Nitroreductase
QR42_17920	COG1846	Transcriptional regulator
QR42_17925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
QR42_17930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
QR42_17935	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
QR42_17940	COG2390	Transcriptional regulator
QR42_17950	COG2755	lipolytic protein G-D-S-L family
QR42_17950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
QR42_17955	COG0477	Major facilitator Superfamily
QR42_17975	COG0561	phosphatase activity
QR42_17980	COG0789	Transcriptional regulator
QR42_17985	COG0673	inositol 2-dehydrogenase activity
QR42_17990	COG0840	transmembrane signaling receptor activity
QR42_17995	COG1113	amino acid transport
QR42_18000	COG4335	DNA alkylation repair
QR42_18010	COG1070	Carbohydrate kinase
QR42_18015	COG1737	Transcriptional regulator
QR42_18050	COG0583	DNA-binding transcription factor activity
QR42_18055	COG1609	Transcriptional regulator
QR42_18060	COG2182	Extracellular solute-binding protein
QR42_18065	COG1175	transmembrane transport
QR42_18070	COG3833	ABC-type maltose transport systems, permease component
QR42_18080	COG1874	Beta-galactosidase
QR42_18085	COG2851	Citrate transporter
QR42_18095	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
QR42_18100	COG1131	(ABC) transporter
QR42_18110	COG2824	Alkylphosphonate utilization operon protein PhnA
QR42_18115	COG1929	Belongs to the glycerate kinase type-1 family
QR42_18120	COG2610	gluconate transmembrane transporter activity
QR42_18125	COG3835	regulator
QR42_18130	COG1309	transcriptional regulator
QR42_18145	COG0577	efflux transmembrane transporter activity
QR42_18145	COG1136	(ABC) transporter
QR42_18155	COG0457	Tetratricopeptide repeat
QR42_18160	COG3711	transcriptional antiterminator
QR42_18165	COG2723	6-phospho-beta-galactosidase activity
QR42_18170	COG2190	(PTS) system
QR42_18170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QR42_18170	COG1263	PTS System
QR42_18210	COG1113	amino acid transport
QR42_18220	COG2814	Major facilitator Superfamily
QR42_18225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
QR42_18230	COG2814	Major facilitator Superfamily
QR42_18255	COG2723	6-phospho-beta-galactosidase activity
QR42_18265	COG2188	Transcriptional regulator
QR42_18280	COG0384	phenazine biosynthesis protein PhzF
QR42_18285	COG0583	DNA-binding transcription factor activity
QR42_18310	COG2814	Major facilitator Superfamily
QR42_18315	COG0640	Transcriptional regulator
QR42_18330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
QR42_18335	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
QR42_18345	COG4720	Psort location CytoplasmicMembrane, score
QR42_18375	COG0456	acetyltransferase
QR42_18380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QR42_18385	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
QR42_18390	COG4853	Protein conserved in bacteria
QR42_18395	COG4863	YycH protein
QR42_18400	COG5002	protein histidine kinase activity
QR42_18405	COG0745	RESPONSE REGULATOR receiver
QR42_18430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QR42_18440	COG2311	Membrane
QR42_18445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
QR42_18450	COG0346	lactoylglutathione lyase activity
QR42_18455	COG0305	Participates in initiation and elongation during chromosome replication
QR42_18480	COG2819	hydrolase of the alpha beta superfamily
QR42_18485	COG1028	Short-chain dehydrogenase reductase Sdr
QR42_18490	COG1169	isochorismate synthase
QR42_18495	COG1021	2,3-dihydroxybenzoate-AMP ligase
QR42_18500	COG1535	isochorismatase
QR42_18500	COG3433	isochorismatase activity
QR42_18505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QR42_18510	COG3251	PFAM MbtH domain protein
QR42_18515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_18515	COG2207	Transcriptional regulator
QR42_18520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QR42_18525	COG2819	hydrolase of the alpha beta superfamily
QR42_18530	COG2807	transmembrane transport
QR42_18535	COG0359	binds to the 23S rRNA
QR42_18540	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
QR42_18545	COG4241	membrane
QR42_18550	COG1227	inorganic diphosphatase activity
QR42_18560	COG1595	DNA-templated transcription, initiation
QR42_18570	COG0753	catalase activity
QR42_18575	COG0655	NAD(P)H dehydrogenase (quinone) activity
QR42_18580	COG0400	carboxylic ester hydrolase activity
QR42_18585	COG0346	lactoylglutathione lyase activity
QR42_18590	COG1174	glycine betaine transport
QR42_18595	COG0517	IMP dehydrogenase activity
QR42_18595	COG1125	glycine betaine transport
QR42_18600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
QR42_18605	COG0629	single-stranded DNA binding
QR42_18610	COG0360	Binds together with S18 to 16S ribosomal RNA
QR42_18615	COG0012	GTP binding
QR42_18620	COG4481	Protein conserved in bacteria
QR42_18635	COG3949	Membrane
QR42_18645	COG1475	DNA binding
QR42_18650	COG1192	Involved in chromosome partitioning
QR42_18660	COG1475	DNA binding
QR42_18665	COG0357	Ribosomal RNA small subunit methyltransferase G
QR42_18670	COG0445	tRNA wobble uridine modification
QR42_18675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
QR42_18680	COG1847	R3H domain protein
QR42_18685	COG0706	membrane insertase activity
QR42_18690	COG0594	ribonuclease P activity