locus-tag class description HW35_00015 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HW35_00020 ENOG4105D7N magnesium and cobalt transport protein CorA HW35_00030 ENOG4107TS3 membrane protein, TerC HW35_00035 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HW35_00040 ENOG4105BZ1 (ABC) transporter HW35_00065 ENOG4108R6K riboflavin synthase, subunit alpha HW35_00075 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HW35_00085 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HW35_00090 ENOG4105EHG Permease protein HW35_00095 ENOG4105E0A ABC, transporter HW35_00100 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HW35_00105 ENOG4107QZB decarboxylase HW35_00110 ENOG4108YZT Adenosylcobinamide kinase HW35_00120 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HW35_00135 ENOG4108WBT adenosyltransferase HW35_00150 ENOG4105BZ4 penicillin-binding protein HW35_00165 ENOG4105E1K spore germination protein HW35_00180 ENOG4107TCE N-acetyltransferase HW35_00195 ENOG4105ER2 Ompa motb domain protein HW35_00200 ENOG4105E14 MotA TolQ exbB proton channel HW35_00205 ENOG4105BZU Histidine kinase HW35_00210 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HW35_00220 ENOG410822I Flagellar hook capping protein HW35_00225 ENOG4108JQA flagellar HW35_00230 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HW35_00235 ENOG4105DD5 Flagellar motor switch protein HW35_00240 ENOG4107YTP response regulator receiver protein HW35_00245 ENOG4105CBS Chea signal transduction histidine kinase HW35_00250 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HW35_00255 ENOG4108V3W Chemotaxis protein, CheW HW35_00260 ENOG4105XVJ Protein of unknown function (DUF327) HW35_00275 ENOG4105CGA flagellar basal-body rod protein FlgG HW35_00280 ENOG4107RT6 flagellar hook-associated HW35_00290 ENOG4105I03 Flagellin HW35_00335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HW35_00390 ENOG41083S7 flagellar protein FlaG HW35_00400 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HW35_00420 ENOG4105E1Q flagellar hook-associated protein HW35_00425 ENOG4105DTJ flagellar hook-associated protein HW35_00440 ENOG4105MQ3 flagellar protein FliS HW35_00460 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HW35_00465 ENOG4108ZC9 flagellar basal-body rod protein flgc HW35_00475 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HW35_00480 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HW35_00510 ENOG4105CN7 Flagellar biosynthetic protein FliP HW35_00515 ENOG4105VS8 Flagellar biosynthetic protein fliq HW35_00520 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HW35_00525 ENOG4105D00 flagellar biosynthetic protein flhB HW35_00530 ENOG4105D7B Flagellar biosynthesis protein flha HW35_00535 ENOG4105FZW flagellar biosynthesis regulator FlhF HW35_00550 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HW35_00555 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HW35_00560 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HW35_00565 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HW35_00580 ENOG4105C59 p-type ATPase HW35_00595 ENOG410681U heavy metal transport detoxification protein HW35_00600 ENOG4105DQ6 Transposase HW35_00610 ENOG4105DEU major facilitator superfamily HW35_00615 ENOG4107XVH Transcriptional regulator HW35_00620 ENOG4105EKQ RNA-directed DNA polymerase HW35_00660 ENOG41067VN Glutaredoxin HW35_00665 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HW35_00670 ENOG4105DWF phosphomethylpyrimidine kinase HW35_00675 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HW35_00690 ENOG4105ETU transcriptional activator (TenA HW35_00700 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HW35_00730 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HW35_00745 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HW35_00790 ENOG4105C0R drug resistance transporter emrb qaca subfamily HW35_00800 ENOG4105C7B Threonine dehydratase HW35_00805 ENOG4105CDY transcriptional regulatory protein HW35_00810 ENOG4108UZ3 Transporter HW35_00840 ENOG4108RAV Conserved protein HW35_00850 ENOG4107414 GntR family transcriptional regulator HW35_00855 ENOG4105CG3 alpha amylase, catalytic region HW35_00860 ENOG4105C5Y PTS System HW35_00865 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HW35_00885 ENOG4105C5H ABC transporter HW35_00900 ENOG4105C2W permease HW35_00905 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HW35_00915 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HW35_00925 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HW35_00955 ENOG410746C Acid-soluble spore protein O HW35_00960 ENOG4108I0Z Aconitate hydratase HW35_00970 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HW35_00980 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HW35_00995 ENOG41067CD Small, acid-soluble spore protein Tlp HW35_01015 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HW35_01020 ENOG4105K4P CoA-binding domain protein HW35_01025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HW35_01045 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HW35_01095 ENOG4105D82 Glutamate dehydrogenase HW35_01100 ENOG4105C8Y Acetylornithine aminotransferase HW35_01105 ENOG4105C26 Dehydrogenase HW35_01110 ENOG4108JUB Transcriptional regulator HW35_01115 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HW35_01130 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HW35_01135 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HW35_01140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HW35_01145 ENOG4105C26 Dehydrogenase HW35_01150 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HW35_01170 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HW35_01175 ENOG4105BZ8 glutamate synthase HW35_01180 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HW35_01185 ENOG4105C0R drug resistance transporter emrb qaca subfamily HW35_01190 ENOG4108IG5 Transcriptional regulator HW35_01200 ENOG41073R8 VanW family HW35_01215 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HW35_01220 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HW35_01225 ENOG4105DUM transcriptional regulator, lysR family HW35_01260 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HW35_01265 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HW35_01275 ENOG4105KJF protein tyrosine phosphatase HW35_01295 ENOG4108R5S membrane HW35_01305 ENOG4105F0V Cell wall hydrolase HW35_01315 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HW35_01340 ENOG4105E2Y ABC, transporter HW35_01345 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HW35_01350 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HW35_01355 ENOG4105GVF (ABC) transporter HW35_01375 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HW35_01380 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HW35_01385 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HW35_01390 ENOG4105CRW Short chain fatty acid transporter HW35_01395 ENOG4105DWD nucleoside recognition domain protein HW35_01420 ENOG41087NI Sulfite exporter TauE/SafE HW35_01425 ENOG4105VFE sira family HW35_01430 ENOG4107TPS domain protein HW35_01440 ENOG4105VFE sira family HW35_01445 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HW35_01450 ENOG4105XTG Pfam:DUF156 HW35_01485 ENOG4105CFF transcriptional regulator HW35_01535 ENOG410751J HW35_01545 ENOG4105K7K Transcriptional regulator HW35_01555 ENOG4105CDU Replicative dna helicase HW35_01570 ENOG4108RZE Tetr family transcriptional regulator HW35_01580 ENOG4105C88 aminopeptidase HW35_01610 ENOG4105CV8 reductase HW35_01615 ENOG4105F27 Major Facilitator HW35_01620 ENOG4105KVH Transcriptional regulator HW35_01655 ENOG4107Y9E nuclease HW35_01660 ENOG4108RCF TRANSCRIPTIONal HW35_01665 ENOG4108903 Formimidoylglutamase HW35_01670 ENOG4105CI2 imidazolone-5-propionate hydrolase HW35_01675 ENOG4105CGP Urocanate hydratase HW35_01680 ENOG4107S6Z Na H antiporter HW35_01695 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HW35_01715 ENOG4105SXS Protein of unknown function (DUF456) HW35_01765 ENOG4105F0V Cell wall hydrolase HW35_01780 ENOG4108IG5 Transcriptional regulator HW35_01795 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HW35_01800 ENOG4105FB2 class II Aldolase HW35_01805 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HW35_01815 ENOG4108I5U Uridine phosphorylase HW35_01825 ENOG4108JJB ABC transporter HW35_01830 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HW35_01835 ENOG4105ETE Transcriptional regulator (LacI family HW35_01845 ENOG4108IPJ Membrane HW35_01865 ENOG4105J4Q Transcriptional regulator HW35_01870 ENOG4105ERH Fumarylacetoacetate hydrolase HW35_01875 ENOG4105C82 Malate synthase HW35_01880 ENOG4105CQB FAD linked oxidase domain protein HW35_01885 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HW35_01890 ENOG4105CQB FAD linked oxidase domain protein HW35_01900 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HW35_01905 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HW35_01910 ENOG410841Q phosphoesterase PA-phosphatase related protein HW35_01920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HW35_01925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HW35_01935 ENOG4105U0R haloacid dehalogenase-like hydrolase HW35_01960 ENOG4105BZ9 Cytochrome C oxidase, subunit I HW35_01965 ENOG4105E2S oxidase) subunit II HW35_01980 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HW35_01985 ENOG4105VRS hydrolase family 18 HW35_02015 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HW35_02020 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HW35_02105 ENOG4105CGK Exodeoxyribonuclease III HW35_02110 ENOG4107ZE5 PPIases accelerate the folding of proteins HW35_02125 ENOG4105EWU Squalene--hopene cyclase HW35_02130 ENOG4105BZU Histidine kinase HW35_02135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HW35_02145 ENOG41073R8 VanW family HW35_02165 ENOG4108JYZ YitT family HW35_02180 ENOG4108QY0 Membrane HW35_02190 ENOG4108IQI permease HW35_02195 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HW35_02230 ENOG4105C5S asparaginyl-tRNA synthetase HW35_02245 ENOG4105EEM helicase HW35_02275 ENOG4107TVC Glycosyl transferase, family 2 HW35_02285 ENOG4106WTF Glycosyl transferase, family 2 HW35_02360 ENOG4105CFH Aspartokinase HW35_02365 ENOG4105P8F nudix hydrolase HW35_02370 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HW35_02400 ENOG4106GRI small acid-soluble spore protein H HW35_02405 ENOG4105EKQ RNA-directed DNA polymerase HW35_02460 ENOG4105EKQ RNA-directed DNA polymerase HW35_02475 ENOG4105C5H ABC transporter HW35_02485 ENOG4106AUC UPF0180 protein HW35_02490 ENOG4105E0C molybdate abc transporter HW35_02495 ENOG4105DZ1 carboxypeptidase HW35_02510 ENOG4105C6N Formate acetyltransferase HW35_02515 ENOG4105F1A Pyruvate formate-lyase HW35_02530 ENOG4105CEY Amp-dependent synthetase and ligase HW35_02550 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HW35_02565 ENOG4105DDQ anthranilate synthase HW35_02570 ENOG4105CRQ synthase (Component I) HW35_02580 ENOG4105DM4 PTS System HW35_02585 ENOG4105DE4 1-phosphofructokinase HW35_02590 ENOG4105E98 transcriptional regulator DeoR family HW35_02600 ENOG4105FDF Could be involved in DNA repair (By similarity) HW35_02605 ENOG4105DQE DNA ligase HW35_02670 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HW35_02680 ENOG4106Z5R HW35_02685 ENOG4108N23 SpoOM-related protein HW35_02705 ENOG4105VSD UPF0346 protein HW35_02715 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HW35_02720 ENOG4108JUB Transcriptional regulator HW35_02725 ENOG4108TSC N-acetyltransferase HW35_02730 ENOG4107S4Y M20 DapE family protein YgeY HW35_02745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HW35_02770 ENOG4105E0X reductase HW35_02775 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HW35_02785 ENOG41090WU lipolytic protein G-D-S-L family HW35_02790 ENOG4108KF3 Electron transport protein SCO1 SenC HW35_02810 ENOG4105VFR signal peptidase HW35_02830 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HW35_02835 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HW35_02845 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HW35_02850 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HW35_02860 ENOG4106FN3 tellurium resistance protein HW35_02865 ENOG4108N0M stress protein HW35_02875 ENOG4108TTB tellurium resistance protein HW35_02885 ENOG4107TS3 membrane protein, TerC HW35_02890 ENOG4106FN3 tellurium resistance protein HW35_02895 ENOG4108Y6J UPF0403 protein HW35_02905 ENOG4105C5H ABC transporter HW35_02930 ENOG4105CVG Homoserine O-transsuccinylase HW35_02935 ENOG4105DQ6 Transposase HW35_02945 ENOG4105KST dependent repressor HW35_02950 ENOG4105C9U ATP-dependent DNA helicase RecQ HW35_03000 ENOG4105KHC sulfurtransferase HW35_03005 ENOG410890F Dynamin family HW35_03015 ENOG41065KQ synthase HW35_03025 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HW35_03030 ENOG4107RQ2 Cytochrome c oxidase, subunit I HW35_03070 ENOG4105DVT helicase HW35_03075 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HW35_03080 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HW35_03085 ENOG4106F55 Protein of unknown function (DUF1273) HW35_03100 ENOG4107X2U Inherit from COG: Exonuclease-like protein HW35_03105 ENOG4108I5C dEAD DEAH box helicase HW35_03110 ENOG4105IJJ transcriptional regulator, crp fnr family HW35_03115 ENOG4107Y70 Heat shock protein HW35_03165 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HW35_03175 ENOG4105CSM endonuclease III HW35_03205 ENOG4105DVT helicase HW35_03210 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HW35_03215 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HW35_03230 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HW35_03235 ENOG4105CPK Glycosyl transferase (Group 1 HW35_03240 ENOG4105FJR Lmbe family HW35_03245 ENOG4108Z5K methylglyoxal synthase HW35_03255 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HW35_03260 ENOG4108JYZ YitT family HW35_03280 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit HW35_03285 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HW35_03290 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HW35_03300 ENOG4108SXZ UPF0302 protein HW35_03305 ENOG41068YB TPR repeat-containing protein HW35_03325 ENOG4105CIH Imidazole acetol-phosphate transaminase HW35_03330 ENOG4105KHN chorismate mutase HW35_03335 ENOG4105D49 3-dehydroquinate synthase HW35_03345 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HW35_03350 ENOG4105EAH synthase HW35_03355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HW35_03360 ENOG4105XXQ heptaprenyl diphosphate synthase component I HW35_03370 ENOG4105EUJ GTP cyclohydrolase i HW35_03375 ENOG4105K70 DNA-binding protein HW35_03380 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HW35_03395 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HW35_03400 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HW35_03420 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HW35_03425 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HW35_03435 ENOG4105CAT Cytidine monophosphate kinase HW35_03445 ENOG4105MSI germination protein ypeb HW35_03460 ENOG4105HDK L-asparaginase HW35_03465 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HW35_03470 ENOG4105EKQ RNA-directed DNA polymerase HW35_03495 ENOG4105WEF catalase HW35_03510 ENOG4105I7S Abortive infection protein HW35_03515 ENOG4105C9U ATP-dependent DNA helicase RecQ HW35_03520 ENOG4105T7X HW35_03530 ENOG4108SAX Membrane HW35_03535 ENOG41068JE domain protein HW35_03555 ENOG4105BZU Histidine kinase HW35_03560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HW35_03565 ENOG4105CRE cytochrome C HW35_03570 ENOG4107TWT Cytochrome c biogenesis protein HW35_03575 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HW35_03580 ENOG4105FE9 pseudouridine synthase HW35_03590 ENOG4108JIC nucleoside recognition domain protein HW35_03595 ENOG4105DZ1 carboxypeptidase HW35_03600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HW35_03615 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HW35_03620 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HW35_03640 ENOG4105PTM secreted protein HW35_03655 ENOG4105G6R Stage v sporulation protein ae HW35_03670 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HW35_03675 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HW35_03685 ENOG4105DZ1 carboxypeptidase HW35_03705 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HW35_03720 ENOG4105I3K Ferric uptake regulator, Fur family HW35_03725 ENOG4105MZ9 stage II sporulation protein m HW35_03735 ENOG4105DQ6 Transposase HW35_03755 ENOG4105CPC Aldo Keto reductase HW35_03765 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HW35_03800 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HW35_03810 ENOG4108IXY short-chain dehydrogenase reductase HW35_03815 ENOG4105II7 pyrroline-5-carboxylate reductase HW35_03820 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HW35_03825 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HW35_03830 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HW35_03835 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HW35_03840 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HW35_03845 ENOG4108HNZ carboxyl transferase HW35_03850 ENOG4108ZVT methylmalonyl-coA epimerase HW35_03860 ENOG4108Y6J UPF0403 protein HW35_03865 ENOG4105DJT lAO AO transport system ATPase HW35_03870 ENOG4105D5P Methylmalonyl-coA mutase HW35_03875 ENOG4105CMN Methylmalonyl-coA mutase HW35_03880 ENOG4105C7S Dehydrogenase HW35_03885 ENOG4105CPP Dehydrogenase, E1 component HW35_03905 ENOG4107RDP Dehydrogenase HW35_03915 ENOG4108JUB Transcriptional regulator HW35_03920 ENOG4106CCJ Protein of unknown function (DUF2627) HW35_03930 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HW35_03935 ENOG4107QQR Sporulation HW35_03940 ENOG4105S1Z Stage IV sporulation protein B HW35_03945 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HW35_03950 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HW35_03965 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HW35_03970 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HW35_03975 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HW35_03980 ENOG4105M7K Involved in the transcription termination process (By similarity) HW35_03985 ENOG4108ZSR alkaline shock protein HW35_03990 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HW35_04015 ENOG410644B Stage III sporulation protein af HW35_04025 ENOG4105KQ4 Stage iii sporulation protein ad HW35_04030 ENOG4108CQH stage III sporulation protein AC HW35_04035 ENOG4105KR5 Stage iii sporulation protein HW35_04040 ENOG4105CD2 stage iii sporulation protein aa HW35_04060 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HW35_04065 ENOG4105DC7 peptidase M24 HW35_04075 ENOG4105CBJ Metal-dependent enzyme HW35_04105 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HW35_04120 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HW35_04135 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HW35_04140 ENOG4105WZW rhodanese family HW35_04145 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HW35_04150 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HW35_04155 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HW35_04160 ENOG4105C0D helicase HW35_04195 ENOG4106855 Competence protein HW35_04225 ENOG4105C5X domain protein HW35_04240 ENOG4105DKQ ROK family HW35_04265 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HW35_04270 ENOG4105WDJ 50S ribosomal protein L33 HW35_04290 ENOG4108UTW Plays a role in the regulation of phosphate uptake HW35_04295 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HW35_04305 ENOG4105C8U phosphate abc transporter HW35_04310 ENOG4105CVA phosphate HW35_04315 ENOG4107RF6 penicillin-binding protein HW35_04340 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HW35_04345 ENOG41063Y9 HW35_04350 ENOG4108U5J '-nucleotidase HW35_04355 ENOG4105N80 Ferric uptake regulator, Fur family HW35_04360 ENOG4105FAV ABC, transporter HW35_04365 ENOG4105FDK ABC transporter HW35_04370 ENOG41069ZM Protein of unknown function (DUF2624) HW35_04375 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HW35_04390 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HW35_04395 ENOG4105EGD dinuclear metal center protein, YbgI family HW35_04410 ENOG4105C1G acyl-Coa dehydrogenase HW35_04415 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HW35_04420 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HW35_04425 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 HW35_04430 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HW35_04445 ENOG4105DQ6 Transposase HW35_04450 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HW35_04455 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HW35_04465 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HW35_04470 ENOG4105KG3 cytidine deaminase HW35_04475 ENOG4107YR5 Diacylglycerol kinase HW35_04485 ENOG4105CTJ Metal Dependent Phosphohydrolase HW35_04490 ENOG4105C9A Phoh family HW35_04500 ENOG41068P3 sporulation protein YqfC HW35_04505 ENOG4105KTH gatB Yqey HW35_04510 ENOG4105VCC 30S ribosomal protein S21 HW35_04520 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HW35_04525 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HW35_04530 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HW35_04535 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HW35_04540 ENOG4105CFG Acts as a chaperone (By similarity) HW35_04545 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HW35_04550 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HW35_04555 ENOG4105CSA Coproporphyrinogen iii oxidase HW35_04560 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HW35_04570 ENOG4108ZRV stage ii sporulation protein p HW35_04580 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HW35_04590 ENOG4105TQK DNA polymerase iii, delta' subunit HW35_04600 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HW35_04605 ENOG4108UK2 deaminase HW35_04610 ENOG4105KQC Competence protein HW35_04620 ENOG4105EKQ RNA-directed DNA polymerase HW35_04625 ENOG4105DXX methyltransferase HW35_04635 ENOG4108WF2 Metal Dependent Phosphohydrolase HW35_04640 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HW35_04645 ENOG410812S Rna-binding protein HW35_04655 ENOG4105CQW ribosome biogenesis GTPase YqeH HW35_04660 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HW35_04670 ENOG4105DJ4 phosphatidylserine decarboxylase HW35_04675 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HW35_04680 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HW35_04705 ENOG4105C28 cystathionine HW35_04725 ENOG4107XRG penicillin-binding protein HW35_04730 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HW35_04735 ENOG4105DBI uridine monophosphokinase HW35_04740 ENOG4105CFP Peptidase U32 HW35_04745 ENOG4105XYU peptidase (U32 family) HW35_04750 ENOG4108VQJ O-methyltransferase HW35_04755 ENOG4105HHA aminodeoxychorismate lyase HW35_04760 ENOG4105VPH UPF0473 protein HW35_04765 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HW35_04770 ENOG4105VBH UPF0297 protein HW35_04775 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HW35_04780 ENOG4105C02 permease HW35_04790 ENOG41060CR HW35_04800 ENOG4105C7H Helicase, RecD TraA family HW35_04810 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HW35_04815 ENOG4105C3J Cysteine desulfurase HW35_04825 ENOG4105D1H recombination factor protein RarA HW35_04835 ENOG4105W8X HesB YadR YfhF-family protein HW35_04840 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HW35_04845 ENOG4105CNN ABC, transporter HW35_04850 ENOG4105C2J ABC transporter HW35_04855 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HW35_04860 ENOG4108RVA ribokinase HW35_04865 ENOG4105ETE Transcriptional regulator (LacI family HW35_04870 ENOG4105CUZ uba thif-type nad fad binding protein HW35_04875 ENOG4105C9M aspartyl-trna synthetase HW35_04880 ENOG4105CUT histidyl-tRNA synthetase HW35_04890 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HW35_04895 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HW35_04900 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HW35_04905 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HW35_04910 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HW35_04920 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HW35_04930 ENOG4105CKP Polysaccharide Biosynthesis Protein HW35_04935 ENOG4108QG2 Membrane HW35_04940 ENOG4105NAP HW35_04945 ENOG4105VIE preprotein translocase, subunit YajC HW35_04955 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HW35_04960 ENOG41061AI Protein of unknown function (DUF2905) HW35_04965 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HW35_04970 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HW35_04995 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HW35_05000 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HW35_05005 ENOG4108IYU L-aspartate oxidase HW35_05020 ENOG4105CQC Prephenate dehydratase HW35_05025 ENOG41090I5 UPF0735 ACT domain-containing protein HW35_05030 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HW35_05040 ENOG4105K46 50S ribosomal protein l27 HW35_05045 ENOG4105X36 (ribosomal) protein HW35_05050 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HW35_05055 ENOG4105C03 ribonuclease HW35_05070 ENOG4107QMS site-determining protein HW35_05075 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HW35_05085 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HW35_05090 ENOG4105DFF Rod shape-determining protein mreb HW35_05095 ENOG4105W5Q DNA repair protein (RadC HW35_05130 ENOG4105CZX twitching motility protein HW35_05135 ENOG4107QHF type ii secretion system protein e HW35_05160 ENOG4106A3R peptidase HW35_05170 ENOG4105BZU Histidine kinase HW35_05175 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HW35_05195 ENOG41068KH stage VI sporulation protein D HW35_05195 ENOG41068KH stage VI sporulation protein D HW35_05210 ENOG4105EKQ RNA-directed DNA polymerase HW35_05215 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HW35_05220 ENOG4105D52 delta-aminolevulinic acid dehydratase HW35_05230 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HW35_05240 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HW35_05255 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HW35_05260 ENOG4108IUQ atp-dependent protease HW35_05265 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HW35_05270 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HW35_05290 ENOG4105CIG ABC transporter HW35_05325 ENOG4105DQ6 Transposase HW35_05345 ENOG4105M59 Phosphodiesterase, mj0936 family HW35_05350 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HW35_05355 ENOG4108FK2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HW35_05360 ENOG4108XJQ germination protein HW35_05370 ENOG41067TZ transcriptional regulator, MarR family HW35_05375 ENOG4105EKQ RNA-directed DNA polymerase HW35_05400 ENOG4105PFC Transcriptional regulator HW35_05410 ENOG4105EKQ RNA-directed DNA polymerase HW35_05415 ENOG4105E33 succinate dehydrogenase HW35_05425 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HW35_05440 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HW35_05445 ENOG4105K63 Thioredoxin HW35_05455 ENOG4105C10 Electron transfer flavoprotein HW35_05460 ENOG4105BZJ Electron transfer flavoprotein HW35_05465 ENOG41060WC Enoyl-CoA hydratase HW35_05470 ENOG4107Z3H Transcriptional regulator, TetR family HW35_05475 ENOG4105CEY Amp-dependent synthetase and ligase HW35_05485 ENOG4105C98 muts2 protein HW35_05490 ENOG4105DCG PHP domain protein HW35_05500 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HW35_05505 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HW35_05525 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HW35_05530 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HW35_05535 ENOG4108RWN rrna methyltransferase HW35_05540 ENOG41067MF small acid-soluble spore protein HW35_05545 ENOG4105CN9 Peptidase m42 family protein HW35_05555 ENOG410696E Membrane HW35_05560 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HW35_05565 ENOG4105VJV 50s ribosomal protein L35 HW35_05570 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HW35_05575 ENOG4105C22 threonyL-tRNA synthetase HW35_05580 ENOG4108TDW sporulation protein YtxC HW35_05595 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HW35_05605 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HW35_05610 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HW35_05615 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HW35_05625 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HW35_05630 ENOG4105C2M dna polymerase I HW35_05640 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HW35_05645 ENOG4105EKQ RNA-directed DNA polymerase HW35_05660 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HW35_05665 ENOG4108HMX isocitrate dehydrogenase (NADP) HW35_05670 ENOG4105BZN citrate synthase HW35_05675 ENOG4108VMM UPF0756 membrane protein HW35_05680 ENOG4108REF Sporulation integral membrane protein ytvi HW35_05685 ENOG4105CA9 Pyruvate kinase HW35_05690 ENOG4105CTQ phosphohexokinase HW35_05695 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HW35_05700 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HW35_05705 ENOG41073TP transcriptional regulator HW35_05710 ENOG4105C6K Malic enzyme HW35_05715 ENOG4105C0B DNA polymerase III (alpha subunit) HW35_05720 ENOG4105VV2 HW35_05730 ENOG4105SFS phosphoesterase RecJ domain protein HW35_05750 ENOG4105E8R UPF0173 metal-dependent hydrolase HW35_05755 ENOG4105DC7 peptidase M24 HW35_05775 ENOG4107YZX Universal stress protein HW35_05785 ENOG4105EPU Molybdenum cofactor synthesis domain protein HW35_05795 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HW35_05805 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HW35_05810 ENOG4105KBJ sporulation protein ytfj HW35_05825 ENOG4105D07 Signal peptide peptidase, SppA HW35_05830 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HW35_05835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HW35_05850 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HW35_05860 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) HW35_05865 ENOG4105U5Y Transcriptional regulator HW35_05875 ENOG4105C28 cystathionine HW35_05885 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HW35_05895 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HW35_05905 ENOG4105F1V Acetoin utilization protein HW35_05910 ENOG4105W87 Cbs domain HW35_05915 ENOG4105DGU Histone deacetylase HW35_05920 ENOG4105ETE Transcriptional regulator (LacI family HW35_05925 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HW35_05945 ENOG4105DFU Cell wall formation (By similarity) HW35_05955 ENOG4108NKM UPF0354 protein HW35_05980 ENOG4105C8F Beta-lactamase domain protein HW35_05985 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HW35_05995 ENOG4108V15 phosphotransferase enzyme family HW35_06000 ENOG4108IUM Glycogen debranching enzyme HW35_06015 ENOG4105C6T cysteine synthase HW35_06045 ENOG4107QSE Dipeptidase HW35_06055 ENOG4105YW5 deoR family transcriptional regulator HW35_06065 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HW35_06080 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HW35_06085 ENOG4108RMU ferritin dps family protein HW35_06100 ENOG4105CBX hi0933 family HW35_06110 ENOG41085GJ domain protein HW35_06115 ENOG4105C8T Leucyl-tRNA synthetase HW35_06120 ENOG410605W Major Facilitator HW35_06135 ENOG4105N5T Radical SAM Protein HW35_06150 ENOG4105E8V Alpha Beta Hydrolase Fold protein HW35_06155 ENOG4108Z0R Transferase HW35_06160 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HW35_06180 ENOG4105D2X ABC transporter substrate-binding protein HW35_06190 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HW35_06205 ENOG4108X4Q Hydrolase HW35_06210 ENOG4105KWG Pfam:DUF1696 HW35_06215 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HW35_06255 ENOG4105DQ6 Transposase HW35_06270 ENOG4108RDQ ABC transporter HW35_06275 ENOG41064SH Protein of unknown function (DUF2705) HW35_06280 ENOG41064J9 HW35_06285 ENOG4106NWU HW35_06290 ENOG41060CM Protein of unknown function (DUF2712) HW35_06315 ENOG4105C7N Xanthine uracil vitamin C permease HW35_06325 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HW35_06330 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HW35_06350 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HW35_06355 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HW35_06360 ENOG4108V2W Carbonate dehydratase HW35_06375 ENOG4105DTQ mandelate racemase muconate lactonizing HW35_06380 ENOG4105CEY Amp-dependent synthetase and ligase HW35_06385 ENOG4108IPT Naphthoate synthase HW35_06390 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HW35_06395 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HW35_06400 ENOG4105E4F Isochorismate synthase HW35_06405 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HW35_06415 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HW35_06555 ENOG4105KT7 mgtC SapB transporter HW35_06595 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HW35_06600 ENOG4105D6E homoserine dehydrogenase HW35_06605 ENOG4108JQ1 Dehydrogenase HW35_06615 ENOG4105C8Q Methyl-accepting chemotaxis HW35_06620 ENOG4105C26 Dehydrogenase HW35_06625 ENOG4105F0V Cell wall hydrolase HW35_06630 ENOG4108RMU ferritin dps family protein HW35_06645 ENOG4107ZQN disulfide bond HW35_06650 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HW35_06655 ENOG4105C28 cystathionine HW35_06660 ENOG4105C28 cystathionine HW35_06680 ENOG4105CZM Major Facilitator HW35_06685 ENOG4105C3M thioredoxin reductase HW35_06700 ENOG4105DQ6 Transposase HW35_06730 ENOG41076HS cation diffusion facilitator family transporter HW35_06805 ENOG4107QW4 alcohol dehydrogenase HW35_06815 ENOG4105C8Y Acetylornithine aminotransferase HW35_06840 ENOG4105C87 Aminotransferase class I and II HW35_06850 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HW35_06870 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HW35_06875 ENOG4105Y38 Kinase-associated protein B HW35_06885 ENOG4105KA0 thioesterase Superfamily protein HW35_06895 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HW35_06900 ENOG41069ER domain protein HW35_06915 ENOG4105CEP NADH dehydrogenase HW35_06935 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HW35_06940 ENOG4105ZKE UPF0349 protein HW35_06955 ENOG41083MR nifu domain-containing protein HW35_06960 ENOG4105C5I Dehydrogenase HW35_06970 ENOG4108W5N phosphatidylglycerophosphatase a HW35_06975 ENOG4105D4U had-superfamily hydrolase, subfamily iia HW35_06995 ENOG4105MMD transcriptional regulator HW35_07000 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HW35_07005 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HW35_07010 ENOG4105FAA peptidase M23 HW35_07015 ENOG4108YTE sporulation protein YunB HW35_07020 ENOG4105KZD Domain of unknown function (DUF1805) HW35_07030 ENOG4105I3N Conserved Protein HW35_07055 ENOG4105DIW FeS assembly protein SUFB HW35_07060 ENOG4108UNV SUF system FeS assembly protein, NifU family HW35_07065 ENOG4105C9B Cysteine desulfurase HW35_07070 ENOG4105JRK feS assembly protein SufD HW35_07075 ENOG4105C3K feS assembly ATPase SufC HW35_07080 ENOG4105D01 (LipO)protein HW35_07085 ENOG4108UMI ABC transporter, permease HW35_07090 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HW35_07130 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HW35_07135 ENOG41080E8 Transcriptional regulator, Spx MgsR family HW35_07150 ENOG4105C1G acyl-Coa dehydrogenase HW35_07155 ENOG4105CHU acetyl-coa acetyltransferase HW35_07180 ENOG4105E0A ABC, transporter HW35_07185 ENOG4108IHU transport system permease protein HW35_07190 ENOG4105DQ5 transport system permease protein HW35_07195 ENOG4108MES Periplasmic binding protein HW35_07215 ENOG410904N short-chain dehydrogenase reductase HW35_07220 ENOG4105DZ6 Band 7 protein HW35_07235 ENOG4105CDA abc transporter atp-binding protein HW35_07240 ENOG4105DRP amino acid AbC transporter HW35_07250 ENOG4105D5Q Arginine ornithine antiporter HW35_07255 ENOG4105C4K Nad synthetase HW35_07260 ENOG4108S4H thioesterase Superfamily protein HW35_07275 ENOG4106F5Q Membrane HW35_07355 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HW35_07360 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HW35_07370 ENOG4105XZU Preprotein translocase, subunit SecG HW35_07395 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HW35_07400 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HW35_07410 ENOG4105BZA Phosphoglycerate kinase HW35_07430 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HW35_07445 ENOG4105C5E polysaccharide biosynthesis protein HW35_07450 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HW35_07455 ENOG4107TY6 Acylneuraminate cytidylyltransferase HW35_07460 ENOG4107DKY pseudaminic acid biosynthesis-associated protein PseG HW35_07470 ENOG4105D2T synthase HW35_07485 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HW35_07495 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HW35_07500 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HW35_07510 ENOG4108TWJ NADH dehydrogenase subunit 5 HW35_07525 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HW35_07540 ENOG4105CZN Potassium uptake protein HW35_07575 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HW35_07590 ENOG4105KRI phosphocarrier protein (HPr HW35_07600 ENOG4105CHW UPF0052 protein HW35_07605 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HW35_07610 ENOG4108Z4K mutator MutT protein HW35_07615 ENOG4105C3M thioredoxin reductase HW35_07630 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HW35_07635 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HW35_07640 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HW35_07645 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HW35_07650 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HW35_07660 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HW35_07665 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HW35_07670 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HW35_07675 ENOG4108S4C acetyltransferase HW35_07685 ENOG4105HKU nucleoside recognition domain-containing protein HW35_07695 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HW35_07700 ENOG41086DT Membrane protein of unknown function HW35_07705 ENOG4108PY7 HW35_07710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HW35_07715 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HW35_07725 ENOG4105BZG amino acid carrier protein HW35_07730 ENOG4105EHZ conserved protein UCP016719 HW35_07735 ENOG4105D17 glycoside hydrolase, family 3 domain protein HW35_07755 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component HW35_07765 ENOG4106KNT transcriptional regulator HW35_07770 ENOG4105PGM cation diffusion facilitator family transporter HW35_07775 ENOG4105DD7 kinase (PfkB family HW35_07780 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HW35_07790 ENOG4108HW3 (ABC) transporter HW35_07795 ENOG4105DRP amino acid AbC transporter HW35_07800 ENOG4105CDA abc transporter atp-binding protein HW35_07820 ENOG4105CN1 protease HW35_07825 ENOG4105DR5 peptidase HW35_07830 ENOG4105CRP Part of the ABC transporter FtsEX involved in HW35_07835 ENOG4105CAK Cell division ATP-binding protein ftsE HW35_07850 ENOG4105EKQ RNA-directed DNA polymerase HW35_07855 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HW35_07860 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HW35_07870 ENOG4105DQ6 Transposase HW35_07885 ENOG4105MJ2 Competence protein HW35_07900 ENOG4105WH1 Two component transcriptional regulator luxr family HW35_07905 ENOG4105BZU Histidine kinase HW35_07910 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HW35_07915 ENOG4105ESV Glycosyl transferase, family 4 HW35_07930 ENOG410838F Glycosyl transferase family 2 HW35_07950 ENOG4105DQ6 Transposase HW35_07960 ENOG4105ESV Glycosyl transferase, family 4 HW35_07965 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HW35_07980 ENOG4105CG5 Glycosyl transferase (Group 1 HW35_07990 ENOG4105WH5 Teichoic acid glycosylation protein HW35_08045 ENOG4106MCE EamA-like transporter family HW35_08050 ENOG4108KN0 Choline kinase HW35_08065 ENOG4105C6Y Udp-glucose 6-dehydrogenase HW35_08070 ENOG4105CEI nitrite reductase HW35_08085 ENOG4105CDW Resistance protein HW35_08095 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HW35_08110 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) HW35_08120 ENOG4108URH decarboxylase HW35_08140 ENOG4108J2R molybdopterin oxidoreductase HW35_08150 ENOG4105CK2 sodium dicarboxylate symporter HW35_08180 ENOG4105C7N Xanthine uracil vitamin C permease HW35_08205 ENOG4108ZB6 transcriptional regulator AsnC family HW35_08210 ENOG4105CHM Aminotransferase HW35_08235 ENOG4107S1E Beta-lactamase HW35_08240 ENOG4105RD7 BadF BadG BcrA BcrD HW35_08265 ENOG4108SU4 UPF0309 protein HW35_08365 ENOG41080HJ 6-phospho 3-hexuloisomerase HW35_08370 ENOG4108VA3 3-hexulose-6-phosphate synthase HW35_08380 ENOG4108UHU Aldolase HW35_08390 ENOG4105D7K pfkb domain protein HW35_08400 ENOG4108PB2 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HW35_08415 ENOG4108UW5 maltose o-acetyltransferase HW35_08460 ENOG410650H (LipO)protein HW35_08465 ENOG4105DBE peroxidase HW35_08470 ENOG4107SJW iron permease, FTR1 HW35_08525 ENOG4105CJ1 ABC, transporter HW35_08545 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HW35_08555 ENOG4105ETD TRANSCRIPTIONal HW35_08570 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HW35_08610 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HW35_08615 ENOG4107QR9 Iron-sulfur cluster binding protein HW35_08620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HW35_08625 ENOG4105JXH GntR family transcriptional regulator HW35_08630 ENOG4105DAA L-lactate HW35_08635 ENOG4105CQB FAD linked oxidase domain protein HW35_08640 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HW35_08705 ENOG4105DG6 mannose-6-phosphate isomerase HW35_08710 ENOG4105DM4 PTS System HW35_08720 ENOG4105EVU fructokinase HW35_08740 ENOG4105DQ6 Transposase HW35_08770 ENOG4105CMR udp-glucose 4-epimerase HW35_08780 ENOG4105C6Y Udp-glucose 6-dehydrogenase HW35_08800 ENOG4107EF8 Glycosyl transferase (Group 1 HW35_08810 ENOG4105C0B DNA polymerase III (alpha subunit) HW35_08815 ENOG4107EF8 Glycosyl transferase (Group 1 HW35_08820 ENOG4105D3Q Sugar transferase HW35_08825 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HW35_08830 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HW35_08835 ENOG4107YJ4 chain length determinant protein HW35_08840 ENOG4105HTX biosynthesis protein HW35_08850 ENOG4105DQ6 Transposase HW35_08885 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein HW35_08890 ENOG4105KBK Zinc finger, swim domain protein HW35_08895 ENOG4105C0D helicase HW35_08905 ENOG41069ER domain protein HW35_08915 ENOG4105EAB amino acid AbC transporter HW35_08920 ENOG4105E5Q amino acid AbC transporter HW35_08925 ENOG4105CDA abc transporter atp-binding protein HW35_08935 ENOG4105Z8H single-stranded DNA-binding protein HW35_08965 ENOG4105DFF Rod shape-determining protein mreb HW35_08970 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HW35_08975 ENOG4107RVG penicillin-binding protein HW35_08985 ENOG4105FRN stage II sporulation protein HW35_09015 ENOG4106778 Protein of unknown function (DUF1146) HW35_09025 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HW35_09030 ENOG4105C8S subunit m HW35_09035 ENOG4105D65 subunit l HW35_09055 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HW35_09060 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HW35_09065 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HW35_09070 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HW35_09075 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HW35_09080 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HW35_09085 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HW35_09090 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HW35_09095 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HW35_09110 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HW35_09115 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HW35_09120 ENOG41062M3 atp synthase HW35_09135 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HW35_09140 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HW35_09155 ENOG4108YZG isomerase HW35_09165 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HW35_09170 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HW35_09180 ENOG4108ZXQ stage ii sporulation protein r HW35_09185 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HW35_09190 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HW35_09200 ENOG4107104 thymidine kinase HW35_09205 ENOG4105VFB Binds the 23S rRNA (By similarity) HW35_09210 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HW35_09215 ENOG4105CBT Fructose-1,6-bisphosphatase HW35_09220 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HW35_09225 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HW35_09230 ENOG4105D2N Aldolase HW35_09235 ENOG410812K response regulator receiver protein HW35_09245 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HW35_09260 ENOG4105D5P Methylmalonyl-coA mutase HW35_09270 ENOG4105C1G acyl-Coa dehydrogenase HW35_09275 ENOG4105C1G acyl-Coa dehydrogenase HW35_09280 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HW35_09290 ENOG4105DF6 Fe-S oxidoreductase HW35_09300 ENOG4105EKQ RNA-directed DNA polymerase HW35_09310 ENOG4105C75 arginyL-tRNA synthetase HW35_09315 ENOG410684U Domain of unknown function (DUF1934) HW35_09320 ENOG4105CYW agmatinase HW35_09325 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HW35_09330 ENOG4105BZ4 penicillin-binding protein HW35_09335 ENOG4108XFG YwhD family HW35_09340 ENOG4108Z4T Peptidase M50 HW35_09345 ENOG41069HH 4-oxalocrotonate tautomerase HW35_09355 ENOG4105DCI Phosphohydrolase HW35_09365 ENOG4108VCI transcription factor, rsfa family HW35_09395 ENOG4108IJ2 phosphate acetyltransferase HW35_09400 ENOG4107JTW chlorite dismutase HW35_09420 ENOG4105D06 uba thif-type nad fad binding protein HW35_09435 ENOG4108ZAF Molybdopterin HW35_09445 ENOG4105DWF phosphomethylpyrimidine kinase HW35_09455 ENOG4108TN2 lmbE family HW35_09475 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) HW35_09495 ENOG4105CJ1 ABC, transporter HW35_09525 ENOG4108IV0 ABC, transporter HW35_09530 ENOG4105C0Z ABC transporter HW35_09535 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HW35_09540 ENOG4105C32 Amino acid ABC transporter (Permease) HW35_09550 ENOG41079KZ Major Facilitator Superfamily HW35_09555 ENOG4105BZ1 (ABC) transporter HW35_09560 ENOG4105BZ1 (ABC) transporter HW35_09570 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HW35_09575 ENOG4105CBC glutamate synthase HW35_09580 ENOG4105C5Q Transcriptional regulator HW35_09585 ENOG4105D82 Glutamate dehydrogenase HW35_09620 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HW35_09635 ENOG4105CMG Carbohydrate kinase HW35_09700 ENOG4108W7F transporter, permease HW35_09705 ENOG4108JJB ABC transporter HW35_09715 ENOG4105ETU transcriptional activator (TenA HW35_09735 ENOG4107F3J Amp-dependent synthetase and ligase HW35_09740 ENOG4107ZYJ bioY protein HW35_09745 ENOG4105EKQ RNA-directed DNA polymerase HW35_09750 ENOG4108WS4 fmn reductase HW35_09765 ENOG4105CVR type I restriction-modification system HW35_09770 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HW35_09780 ENOG4105C0H protease HW35_09785 ENOG4105Q2H domain protein HW35_09800 ENOG4105BZU Histidine kinase HW35_09805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HW35_09810 ENOG4105E4C Lytic transglycosylase catalytic HW35_09835 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HW35_09845 ENOG4105CDU Replicative dna helicase HW35_09855 ENOG4105BZR domain protein HW35_09875 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HW35_09880 ENOG4108UUM single-stranded DNA-binding protein HW35_09885 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HW35_09890 ENOG4105C3G gtp-binding protein HW35_09895 ENOG4108J2R molybdopterin oxidoreductase HW35_09900 ENOG4105VDK protein, conserved in bacteria HW35_09905 ENOG4105D8X mechanosensitive ion channel HW35_09910 ENOG4108ZDA Sporulation protein YyaC HW35_09920 ENOG4105FA0 parb-like partition protein HW35_09925 ENOG4107QJE Chromosome Partitioning Protein HW35_09930 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) HW35_09945 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HW35_09955 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HW35_09960 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HW35_09970 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HW35_09975 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HW35_09980 ENOG410848D S4 domain protein YaaA HW35_09985 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HW35_09995 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HW35_10000 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HW35_10040 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HW35_10050 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HW35_10055 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HW35_10070 ENOG4105ZMH deoxynucleoside kinase HW35_10080 ENOG4105VRS hydrolase family 18 HW35_10085 ENOG4108Z6B deaminase HW35_10090 ENOG4105C6E dna polymerase iii HW35_10100 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HW35_10110 ENOG41067KS pro-sigma K processing HW35_10145 ENOG4105CXN decarboxylase HW35_10150 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HW35_10155 ENOG4105X0R protein from nitrogen regulatory protein P-II HW35_10160 ENOG4105FA2 dna polymerase iii HW35_10165 ENOG4105MA4 psp1 domain protein HW35_10170 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) HW35_10175 ENOG41060K3 Methyltransferase HW35_10180 ENOG4105VC4 domain protein HW35_10185 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HW35_10190 ENOG4105KRN Transcriptional regulator, abrb family HW35_10205 ENOG4105F8V Hydrolase, tatD family HW35_10210 ENOG41069ER domain protein HW35_10215 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HW35_10220 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HW35_10225 ENOG4105XFA sporulation peptidase YabG HW35_10230 ENOG4105W42 Veg protein HW35_10245 ENOG4105DFT pur operon repressor HW35_10250 ENOG4105KME endoribonuclease L-psp HW35_10255 ENOG4105K4W Could be involved in septation (By similarity) HW35_10260 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HW35_10265 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HW35_10270 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HW35_10275 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HW35_10285 ENOG4108JA2 transcriptioN-repair coupling factor HW35_10290 ENOG4108M14 stage v sporulation protein t HW35_10300 ENOG4108IY2 MazG family HW35_10305 ENOG41082I2 s4 domain protein HW35_10310 ENOG4105VYY sporulation protein yabp HW35_10325 ENOG41060GV RNA binding s1 domain protein HW35_10350 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HW35_10355 ENOG4108UGV hypoxanthine phosphoribosyltransferase HW35_10360 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HW35_10365 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HW35_10370 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HW35_10375 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HW35_10385 ENOG4105C6T cysteine synthase HW35_10390 ENOG4105EEI dihydropteroate synthase HW35_10395 ENOG4105KRF dihydroneopterin aldolase HW35_10400 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HW35_10410 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HW35_10420 ENOG4105W1N transcriptional regulator HW35_10425 ENOG4105IIP Membrane HW35_10570 ENOG4108Z0C Uvrb UvrC protein HW35_10575 ENOG41066A3 ATP guanido phosphotransferase HW35_10585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HW35_10590 ENOG4105CTP PilT protein domain protein HW35_10595 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HW35_10600 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HW35_10605 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HW35_10610 ENOG4105D7W serine acetyltransferase HW35_10615 ENOG4105C8N cysteinyl-tRNA synthetase HW35_10625 ENOG4105C2N RNA methyltransferase TrmH family group 3 HW35_10630 ENOG4105M0M Tetracycline resistance protein HW35_10635 ENOG4105QIV RNA polymerase HW35_10645 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HW35_10650 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HW35_10655 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HW35_10660 ENOG4108VZM 50s ribosomal protein L10 HW35_10665 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HW35_10670 ENOG4107Y49 methyltransferase HW35_10675 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HW35_10685 ENOG4105XPM ribosomal protein HW35_10690 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HW35_10695 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HW35_10700 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HW35_10705 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HW35_10710 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HW35_10715 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HW35_10720 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HW35_10725 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HW35_10730 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HW35_10735 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HW35_10740 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HW35_10745 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HW35_10750 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HW35_10755 ENOG41082SA 50s ribosomal protein l29 HW35_10765 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HW35_10770 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HW35_10775 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HW35_10780 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HW35_10785 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HW35_10790 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HW35_10795 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HW35_10800 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HW35_10805 ENOG4105VPB 50S ribosomal protein L30 HW35_10810 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HW35_10815 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HW35_10820 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HW35_10825 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HW35_10830 ENOG41067V7 50S ribosomal protein L36 HW35_10835 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HW35_10840 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HW35_10845 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HW35_10850 ENOG4108ZT0 50S ribosomal protein l17 HW35_10855 ENOG4108JJB ABC transporter HW35_10860 ENOG4108JJB ABC transporter HW35_10865 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HW35_10870 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HW35_10875 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HW35_10880 ENOG4108UJD 30S ribosomal protein S9 HW35_10900 ENOG4108JJB ABC transporter HW35_10925 ENOG4107X8C Efflux transporter RND family MFP subunit HW35_10930 ENOG4105C19 ABC transporter HW35_10935 ENOG4107RBB ABC transporter, permease HW35_10950 ENOG4108B31 Spore germination protein HW35_10970 ENOG4105D1F ATP-binding protein HW35_10985 ENOG4108NMV polysaccharide deacetylase HW35_11065 ENOG4105EMN RNA polymerase sigma factor HW35_11075 ENOG4105C8B TIGR00159 family HW35_11080 ENOG4107U5W ybbr family HW35_11085 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HW35_11095 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HW35_11140 ENOG41090UD (LipO)protein HW35_11155 ENOG41080BT SNARE associated Golgi HW35_11160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HW35_11165 ENOG4105BZU Histidine kinase HW35_11180 ENOG4105EMD TRANSCRIPTIONal HW35_11185 ENOG4105CK1 PTS System HW35_11190 ENOG4105VZJ PTS System HW35_11195 ENOG4105VCP PTS System HW35_11200 ENOG4105CS2 ec 3.2.1.21 HW35_11230 ENOG4105K56 Transcriptional regulator HW35_11255 ENOG4105ETD TRANSCRIPTIONal HW35_11275 ENOG4105VMP Transcriptional regulator HW35_11280 ENOG4105BZU Histidine kinase HW35_11295 ENOG4108Z0Z intracellular protease Pfpi family HW35_11300 ENOG4105EYF MMPL domain protein HW35_11340 ENOG4105C75 arginyL-tRNA synthetase HW35_11350 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HW35_11360 ENOG41080TC multidrug resistance protein HW35_11365 ENOG4107T5V SNARE associated Golgi HW35_11375 ENOG4105CJW magnesium transporter HW35_11385 ENOG4105CPF Cell wall formation (By similarity) HW35_11390 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HW35_11410 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HW35_11415 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HW35_11430 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HW35_11455 ENOG410906U SprT-like HW35_11535 ENOG4105K8N protein family UPF0079, ATPase HW35_11540 ENOG41072GX Peptidase M22 Glycoprotease HW35_11545 ENOG410801F ribosomal-protein-alanine acetyltransferase HW35_11550 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HW35_11555 ENOG4105C5H ABC transporter HW35_11565 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HW35_11575 ENOG4108TYN CAAX amino terminal protease family protein HW35_11580 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HW35_11585 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HW35_11590 ENOG4105E2R ROK family HW35_11600 ENOG4107QNK )-transporter HW35_11605 ENOG4105CMG Carbohydrate kinase HW35_11610 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HW35_11630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HW35_11635 ENOG4105C7N Xanthine uracil vitamin C permease HW35_11640 ENOG4105CID antiterminator HW35_11680 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HW35_11685 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HW35_11690 ENOG4105C83 adenylosuccinate lyase HW35_11695 ENOG4105C8V SAICAR synthetase HW35_11700 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HW35_11705 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HW35_11710 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HW35_11720 ENOG4105CXB phosphoribosylaminoimidazole synthetase HW35_11725 ENOG4108V3E phosphoribosylglycinamide formyltransferase HW35_11730 ENOG4105DC1 bifunctional purine biosynthesis protein purh HW35_11735 ENOG4105C12 Phosphoribosylglycinamide synthetase HW35_11750 ENOG4108R5T secreted protein HW35_11755 ENOG4105KGF protein, YerC YecD HW35_11760 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HW35_11765 ENOG4105C4R Atp-dependent dna helicase HW35_11770 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HW35_11780 ENOG4105C26 Dehydrogenase HW35_11785 ENOG4108IFG nitrite reductase, (NAD(P)H) HW35_11790 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HW35_11810 ENOG4108X3M OsmC Ohr family protein HW35_11820 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HW35_11825 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HW35_11830 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HW35_11840 ENOG4105CK7 Sodium proline symporter HW35_11845 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HW35_11855 ENOG4105CBD Diacylglycerol kinase HW35_11860 ENOG4105DAP Nicotinate phosphoribosyltransferase HW35_11930 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HW35_11945 ENOG4105NAA Cytochrome C oxidase, subunit II HW35_11950 ENOG4107RQ2 Cytochrome c oxidase, subunit I HW35_11970 ENOG4105C37 (CBS) domain HW35_11975 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HW35_12005 ENOG4105DHS permease protein HW35_12010 ENOG4105CM4 permease protein HW35_12015 ENOG4108IPW abc transporter atp-binding protein HW35_12025 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HW35_12030 ENOG4108XRC Protein of unknown function (DUF458) HW35_12050 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HW35_12055 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HW35_12060 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HW35_12065 ENOG4105CMR udp-glucose 4-epimerase HW35_12070 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase HW35_12075 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HW35_12085 ENOG4105D4B ABC, transporter HW35_12090 ENOG4105C2F Histidine kinase HW35_12095 ENOG4107YTP response regulator receiver protein HW35_12105 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HW35_12110 ENOG4105C2J ABC transporter HW35_12115 ENOG4108HWV )-transporter HW35_12120 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HW35_12125 ENOG4105DVE abc transporter atp-binding protein HW35_12135 ENOG4105JVQ RNA Polymerase HW35_12150 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HW35_12175 ENOG4105DAA L-lactate HW35_12190 ENOG4105C94 Transporter HW35_12215 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HW35_12220 ENOG4105EHG Permease protein HW35_12225 ENOG4105DQ5 transport system permease protein HW35_12235 ENOG4105E0A ABC, transporter HW35_12240 ENOG4105CAY ferredoxin--nadp reductase HW35_12250 ENOG4105CN5 Metallo-Beta-Lactamase HW35_12255 ENOG4105EKQ RNA-directed DNA polymerase HW35_12270 ENOG4105C19 ABC transporter HW35_12275 ENOG4105EWM Histidine kinase HW35_12280 ENOG4105CJZ response regulator HW35_12285 ENOG4105D9N nucleoside HW35_12290 ENOG4107R6U sodium dicarboxylate symporter HW35_12295 ENOG4108YZ4 nudix hydrolase HW35_12310 ENOG4105EE0 oxidoreductase HW35_12325 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HW35_12350 ENOG4108HGU Histidine kinase HW35_12360 ENOG4108JPW Aminotransferase HW35_12365 ENOG4107V2S Transcriptional regulator HW35_12380 ENOG4105CNT hydrolase family 2 HW35_12400 ENOG4105CT1 (ABC) transporter HW35_12405 ENOG4105EAD ABC transporter HW35_12410 ENOG4105DRP amino acid AbC transporter HW35_12415 ENOG4105DQ6 Transposase HW35_12430 ENOG4105D06 uba thif-type nad fad binding protein HW35_12435 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HW35_12445 ENOG41080HI glycine oxidase HW35_12450 ENOG4108VEU Thiamine monophosphate synthase HW35_12470 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HW35_12480 ENOG41069ER domain protein HW35_12490 ENOG4107RWR Sodium hydrogen exchanger HW35_12510 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HW35_12515 ENOG4105C2J ABC transporter HW35_12520 ENOG4105CNN ABC, transporter HW35_12525 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HW35_12530 ENOG4105ETE Transcriptional regulator (LacI family HW35_12535 ENOG4105CK5 oxidoreductase HW35_12550 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HW35_12555 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HW35_12560 ENOG4105D2N Aldolase HW35_12565 ENOG4105DH8 myo-inositol catabolism HW35_12575 ENOG4105M6F mutator MutT protein HW35_12585 ENOG4105DHI Methyltransferase HW35_12590 ENOG4105F6J Alpha beta hydrolase fold HW35_12610 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HW35_12625 ENOG4108IA2 Sodium pantothenate symporter HW35_12630 ENOG41080XP Cbs domain HW35_12635 ENOG4105K4I Scp-like extracellular HW35_12655 ENOG4105DJ2 Major Facilitator Superfamily HW35_12680 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HW35_12695 ENOG4107QNR UPF0135 protein HW35_12710 ENOG4105C19 ABC transporter HW35_12735 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HW35_12740 ENOG4105E4F Isochorismate synthase HW35_12745 ENOG4105WQI isochorismatase HW35_12755 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HW35_12760 ENOG4105WQI isochorismatase HW35_12765 ENOG4105CEY Amp-dependent synthetase and ligase HW35_12830 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HW35_12835 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HW35_12840 ENOG4108UX3 '-nucleotidase HW35_12850 ENOG4108RPX mosc domain containing protein HW35_12875 ENOG4105CZ9 Domain of unknown function (DU1801) HW35_12900 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HW35_12920 ENOG4105C8J )-transporter HW35_12955 ENOG4105WD1 Membrane HW35_12980 ENOG4106IPI cyclase, family HW35_12985 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HW35_12990 ENOG4105C85 amino acid HW35_13010 ENOG4105EFA 4-hydroxyphenylacetate HW35_13015 ENOG4107V0Z fmn reductase HW35_13030 ENOG4105KME endoribonuclease L-psp HW35_13060 ENOG4108IJ0 Aspartate ammonia-lyase HW35_13070 ENOG4105NCW Trka-c domain protein HW35_13075 ENOG4107S91 Sodium hydrogen exchanger HW35_13080 ENOG4107HP6 Transcriptional regulator HW35_13105 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HW35_13125 ENOG4108Z18 K06886 hemoglobin HW35_13130 ENOG4105XN3 extracellular solute-binding protein family 1 HW35_13155 ENOG4105CK5 oxidoreductase HW35_13160 ENOG4105CK5 oxidoreductase HW35_13220 ENOG4105K78 MarR family Transcriptional regulator HW35_13225 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HW35_13230 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HW35_13235 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HW35_13240 ENOG4105DT3 PTS system, galactitol-specific IIc component HW35_13245 ENOG4105CPQ Dehydrogenase HW35_13270 ENOG4105DQ6 Transposase HW35_13275 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HW35_13280 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HW35_13285 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HW35_13290 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HW35_13295 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HW35_13300 ENOG4108ZP8 Acetolactate synthase small subunit HW35_13305 ENOG4105C7K acetolactate synthase HW35_13310 ENOG4105C01 Dihydroxy-acid dehydratase HW35_13315 ENOG4105CM2 brancheD-chain amino acid aminotransferase HW35_13325 ENOG4105V75 Transcriptional regulator HW35_13335 ENOG4106PMH Extracellular solute-binding protein family 3 HW35_13340 ENOG4105E5Q amino acid AbC transporter HW35_13345 ENOG4105CDA abc transporter atp-binding protein HW35_13360 ENOG4105CHU acetyl-coa acetyltransferase HW35_13375 ENOG4105C9U ATP-dependent DNA helicase RecQ HW35_13395 ENOG4105C2J ABC transporter HW35_13400 ENOG4105CNN ABC, transporter HW35_13410 ENOG4105D22 carbon starvation protein HW35_13415 ENOG4105DWK Membrane HW35_13425 ENOG4108HRK Histidine kinase HW35_13430 ENOG4108NEV two component transcriptional regulator, LytTR family HW35_13440 ENOG4105CUB amino acid HW35_13445 ENOG4105DQ6 Transposase HW35_13455 ENOG4105BZU Histidine kinase HW35_13460 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HW35_13475 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HW35_13505 ENOG4105BZU Histidine kinase HW35_13510 ENOG4105WH1 Two component transcriptional regulator luxr family HW35_13565 ENOG4105IJJ transcriptional regulator, crp fnr family HW35_13590 ENOG4106U2H Protein of unknown function (DUF1360) HW35_13615 ENOG4105WH1 Two component transcriptional regulator luxr family HW35_13625 ENOG4105DQ6 Transposase HW35_13630 ENOG4106I4J membrane HW35_13635 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HW35_13650 ENOG4105C9U ATP-dependent DNA helicase RecQ HW35_13655 ENOG4105C84 Histidine ammonia-lyase HW35_13690 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HW35_13695 ENOG41068PA UPF0435 protein HW35_13705 ENOG4107U9T Pfam:Ribonuclease_BN HW35_13715 ENOG4105DQ6 Transposase HW35_13725 ENOG4105C59 p-type ATPase HW35_13730 ENOG4108ISG Major Facilitator HW35_13740 ENOG4105UPD Calcium Proton HW35_13770 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HW35_13795 ENOG4105G7B Protein of unknown function (DUF2992) HW35_13800 ENOG4108UXE Protein tyrosine phosphatase HW35_13805 ENOG4107R5R arsenical pump membrane protein HW35_13810 ENOG41082YX Transcriptional regulator, arsr family HW35_13815 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HW35_13850 ENOG41086D8 Transcriptional regulator HW35_13865 ENOG4105BZW Glycerate kinase HW35_13880 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HW35_13890 ENOG410645S MarR family Transcriptional regulator HW35_13900 ENOG4105F6S Spore photoproduct lyase HW35_13920 ENOG4105WMR Protein CrcB homolog HW35_13925 ENOG41084I6 Protein CrcB homolog HW35_13940 ENOG4105FDT acyl-CoA dehydrogenase HW35_13965 ENOG4108KS4 Spore coat protein HW35_13970 ENOG4108KS4 Spore coat protein HW35_13990 ENOG4108KS4 Spore coat protein HW35_14000 ENOG4105FB9 CRISPR-associated protein HW35_14020 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HW35_14025 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) HW35_14040 ENOG4107VFR oxidoreductase HW35_14055 ENOG4108IUE nitrate reductase beta subunit HW35_14060 ENOG4105R3A Nitrate reductase HW35_14075 ENOG4105CSV Glutaminase HW35_14085 ENOG4107TXC Transcriptional regulator HW35_14090 ENOG4105C3U ABC transporter HW35_14095 ENOG4108JQ7 (ABC) transporter HW35_14100 ENOG4105DEF Extracellular solute-binding protein, family 5 HW35_14105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HW35_14110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HW35_14115 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HW35_14120 ENOG4105FF2 Type I DHQase HW35_14125 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HW35_14130 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HW35_14135 ENOG4105CAS nag kinase HW35_14140 ENOG4105C8Y Acetylornithine aminotransferase HW35_14145 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HW35_14150 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HW35_14155 ENOG4105DBV ornithine carbamoyltransferase HW35_14160 ENOG4105CDH Citrulline--aspartate ligase HW35_14165 ENOG4105CH7 arginosuccinase HW35_14170 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HW35_14195 ENOG410902V Modulates RecA activity (By similarity) HW35_14205 ENOG4105E1V na solute symporter HW35_14210 ENOG4106CAD Protein of unknown function (DUF3311) HW35_14225 ENOG4105XHU Acid-soluble spore protein K HW35_14235 ENOG41067AE Membrane-bound metal-dependent hydrolase HW35_14240 ENOG4105CEN a g-specific adenine glycosylase HW35_14245 ENOG4106BXE HW35_14250 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HW35_14270 ENOG4105BZ1 (ABC) transporter HW35_14275 ENOG4107NBY Membrane HW35_14280 ENOG4105CBC glutamate synthase HW35_14285 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HW35_14290 ENOG4108IUW ABC transporter HW35_14310 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HW35_14315 ENOG4108WBT adenosyltransferase HW35_14320 ENOG4105G5W regulator Fur family HW35_14325 ENOG4105TUA UPF0295 protein HW35_14420 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HW35_14435 ENOG4108C33 Resolvase HW35_14450 ENOG4105CNU cell division protein FtsK HW35_14530 ENOG4105VN1 Heat shock protein HW35_14560 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HW35_14565 ENOG4105DQ6 Transposase HW35_14590 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HW35_14600 ENOG4105CYN Serine protein kinase HW35_14605 ENOG4106AKX UPF0229 protein HW35_14610 ENOG4105CI1 PTS System HW35_14615 ENOG4105CE4 GlcNAc 6-P deacetylase HW35_14620 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HW35_14625 ENOG4105FDP GntR family transcriptional regulator HW35_14630 ENOG4105K4I Scp-like extracellular HW35_14645 ENOG4105BZU Histidine kinase HW35_14665 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HW35_14670 ENOG4105CJ3 phosphate transporter HW35_14675 ENOG4107GRR phosphate transport regulator HW35_14680 ENOG4107BMA Transglycosylase associated protein HW35_14685 ENOG4108YBP pseudouridine synthase HW35_14715 ENOG4105ED1 spovr family HW35_14720 ENOG4105DCF alanine dehydrogenase HW35_14725 ENOG4108K8K Transcriptional regulator HW35_14735 ENOG4105EKQ RNA-directed DNA polymerase HW35_14740 ENOG4106BRA Membrane HW35_14745 ENOG4105W8X HesB YadR YfhF-family protein HW35_14770 ENOG4105C37 (CBS) domain HW35_14775 ENOG41068WN HW35_14780 ENOG4105BZU Histidine kinase HW35_14785 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HW35_14830 ENOG410839P HW35_14845 ENOG4105WZB UPF0342 protein HW35_14855 ENOG4105D4P Coproporphyrinogen iii oxidase HW35_14860 ENOG4105CGU Enoyl-CoA hydratase HW35_14870 ENOG4108IUX (ABC) transporter HW35_14875 ENOG4105RHA ABC transporter, permease HW35_14880 ENOG4107VRP DNA repair exonuclease HW35_14885 ENOG4106D4I domain protein HW35_14890 ENOG4105EQI Metal Dependent Phosphohydrolase HW35_14900 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HW35_14920 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) HW35_14930 ENOG4105NBU tryptophan transport protein HW35_14935 ENOG4105K59 histidine triad (HIT) protein HW35_14975 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HW35_14980 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HW35_14985 ENOG4105C1Q protoporphyrinogen oxidase HW35_14990 ENOG4105ECB domain protein HW35_14995 ENOG4108RQ5 Beta-lactamase domain-containing protein HW35_15000 ENOG4105DF9 Lipoate-protein, ligase HW35_15005 ENOG4105CEY Amp-dependent synthetase and ligase HW35_15010 ENOG4105E39 Enoyl-CoA hydratase HW35_15015 ENOG4108UMN azlc family HW35_15025 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HW35_15040 ENOG41060YP HW35_15050 ENOG4108RCF TRANSCRIPTIONal HW35_15070 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HW35_15105 ENOG4105YHS UPF0344 protein HW35_15115 ENOG4105CAQ asparagine synthetase HW35_15125 ENOG4108VPT UPF0234 protein HW35_15130 ENOG4105QNR S1 RNA binding domain protein HW35_15140 ENOG4105EKQ RNA-directed DNA polymerase HW35_15145 ENOG4105EPR degv family HW35_15165 ENOG41073B9 HW35_15175 ENOG4108KP7 hydrolase HW35_15180 ENOG4105VG1 fes assembly suf system protein HW35_15195 ENOG4107V6Q Cyclic nucleotide-binding domain HW35_15200 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HW35_15205 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HW35_15210 ENOG4105CVM Molybdenum cofactor synthesis domain protein HW35_15215 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HW35_15225 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HW35_15245 ENOG4107RMD Basic membrane lipoprotein HW35_15250 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HW35_15255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HW35_15265 ENOG4105C3U ABC transporter HW35_15270 ENOG4108JQ7 (ABC) transporter HW35_15285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HW35_15290 ENOG4108KU1 UPF0736 protein HW35_15295 ENOG4105C31 Tryptophanyl-tRNA synthetase HW35_15305 ENOG4107QSI ABC, transporter HW35_15310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HW35_15315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HW35_15325 ENOG4108JQ7 (ABC) transporter HW35_15335 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HW35_15345 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HW35_15355 ENOG4105DPN Oligoendopeptidase f HW35_15365 ENOG4105T58 Dithiol-disulfide isomerase HW35_15370 ENOG4108Z18 K06886 hemoglobin HW35_15375 ENOG4105MIX Adenylate cyclase HW35_15390 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HW35_15395 ENOG4105EMS pseudouridine synthase HW35_15400 ENOG4107S1Q Phosphatase HW35_15410 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HW35_15445 ENOG41090VF Stage v sporulation protein ac HW35_15450 ENOG4105CZ3 stage V sporulation protein ad HW35_15515 ENOG4105DQ6 Transposase HW35_15525 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HW35_15540 ENOG4107X8C Efflux transporter RND family MFP subunit HW35_15545 ENOG4105C19 ABC transporter HW35_15550 ENOG4107RBB ABC transporter, permease HW35_15555 ENOG4105EKQ RNA-directed DNA polymerase HW35_15565 ENOG4105CRQ synthase (Component I) HW35_15570 ENOG4105DDQ anthranilate synthase HW35_15575 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HW35_15595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HW35_15610 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HW35_15620 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HW35_15625 ENOG4108WZW RNA polymerase sigma HW35_15635 ENOG410681C small acid-soluble spore protein HW35_15660 ENOG4105EJ5 oxidoreductase gamma subunit HW35_15665 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HW35_15670 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HW35_15685 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HW35_15690 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HW35_15695 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HW35_15700 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HW35_15710 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HW35_15720 ENOG4105F6E Acyl-transferase HW35_15725 ENOG4108K88 Membrane HW35_15745 ENOG41090MY MarR family Transcriptional regulator HW35_15750 ENOG4105BZU Histidine kinase HW35_15755 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HW35_15785 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HW35_15790 ENOG4105KRI phosphocarrier protein (HPr HW35_15795 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HW35_15800 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HW35_15815 ENOG4105DQ6 Transposase HW35_15820 ENOG4105CHM Aminotransferase HW35_15825 ENOG4105UIN HW35_15830 ENOG4105BZU Histidine kinase HW35_15865 ENOG4105EPM Diguanylate phosphodiesterase HW35_15875 ENOG4107IN1 Protein of unknown function (DUF1797) HW35_15885 ENOG4105C0R drug resistance transporter emrb qaca subfamily HW35_15900 ENOG4105CH2 amidohydrolase HW35_15905 ENOG4107ZYR domain protein HW35_15910 ENOG4105DQ6 Transposase HW35_15915 ENOG4105CN5 Metallo-Beta-Lactamase HW35_15920 ENOG4106148 UPF0356 protein HW35_15940 ENOG4105C7S Dehydrogenase HW35_15965 ENOG4105CXN decarboxylase HW35_15970 ENOG4105EA8 2-Nitropropane dioxygenase HW35_15975 ENOG4105WBI UPF0223 protein HW35_16000 ENOG4108WQ8 UPF0637 protein HW35_16010 ENOG4105ECY inositol monophosphatase HW35_16020 ENOG4105CI3 gtp-binding protein typa HW35_16025 ENOG4105QA2 HW35_16050 ENOG4108IAB Phoh family HW35_16065 ENOG4105CNI cell division protein FtsW HW35_16070 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HW35_16080 ENOG4105DQ6 Transposase HW35_16090 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HW35_16130 ENOG41080XQ Signal transduction protein with cbs domains HW35_16135 ENOG4106UY4 Inherit from COG: Scp-like extracellular HW35_16180 ENOG4105DQ6 Transposase HW35_16185 ENOG4106H78 methyltransferase HW35_16190 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HW35_16205 ENOG4105H20 Sporulation integral membrane protein YlbJ HW35_16210 ENOG4105D78 K07001 NTE family protein HW35_16215 ENOG41063PX domain protein HW35_16220 ENOG4105CDE UPF0348 protein HW35_16225 ENOG4105KNH Nucleic acid-binding protein HW35_16230 ENOG41067VY 50S ribosomal protein L32 HW35_16235 ENOG4105E39 Enoyl-CoA hydratase HW35_16250 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HW35_16255 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HW35_16260 ENOG4107QX3 carboxylase HW35_16275 ENOG41074B2 UPF0747 protein HW35_16280 ENOG4108V6E Cell division protein mraZ HW35_16290 ENOG41068DC Essential cell division protein (By similarity) HW35_16295 ENOG4105CJN penicillin-binding protein HW35_16300 ENOG4105CJN penicillin-binding protein HW35_16305 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HW35_16315 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HW35_16320 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HW35_16325 ENOG4105CNI cell division protein FtsW HW35_16330 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HW35_16335 ENOG4105D4A Cell wall formation (By similarity) HW35_16340 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HW35_16345 ENOG4108R2U division initiation protein HW35_16355 ENOG4105K67 small basic protein HW35_16360 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HW35_16365 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HW35_16375 ENOG4105EKQ RNA-directed DNA polymerase HW35_16380 ENOG4108AWX Sporulation factor SpoIIGA HW35_16385 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HW35_16400 ENOG4105WR5 sporulation protein, YlmC YmxH family HW35_16405 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HW35_16410 ENOG4105DFA alanine racemase domain protein HW35_16415 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HW35_16420 ENOG41067XK integral membrane protein HW35_16425 ENOG4105DBK s4 domain protein HW35_16435 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HW35_16450 ENOG4105C34 Pseudouridine synthase HW35_16455 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HW35_16470 ENOG4105CXT aspartate transcarbamylase HW35_16490 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HW35_16495 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HW35_16500 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HW35_16510 ENOG4105F23 Fibronectin-binding protein HW35_16520 ENOG4105DSJ YicC domain protein HW35_16525 ENOG4105KC4 UPF0296 protein HW35_16530 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HW35_16535 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HW35_16540 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HW35_16545 ENOG4105C25 Primosomal protein n' HW35_16550 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HW35_16555 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HW35_16560 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HW35_16565 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HW35_16570 ENOG4108ZF3 Phosphatase HW35_16575 ENOG4105D9P serine threonine protein kinase HW35_16580 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HW35_16585 ENOG4105DJV ribulose-phosphate 3-epimerase HW35_16590 ENOG4105FJ0 thiamine HW35_16600 ENOG4105VB9 50S ribosomal protein l28 HW35_16605 ENOG4108ZAA Alkaline-shock protein HW35_16610 ENOG4105DP4 dak2 domain fusion protein ylov HW35_16620 ENOG4105EJQ L-serine dehydratase HW35_16625 ENOG4105CB5 ATP-dependent DNA helicase recG HW35_16630 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HW35_16640 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HW35_16645 ENOG4105CHR reductase HW35_16650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HW35_16655 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HW35_16660 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HW35_16665 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HW35_16670 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HW35_16680 ENOG4105K5M 30s ribosomal protein S16 HW35_16685 ENOG4105VB6 UPF0109 protein HW35_16695 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HW35_16700 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HW35_16705 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HW35_16715 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HW35_16725 ENOG4105CMV Succinyl-CoA synthetase subunit beta HW35_16730 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HW35_16735 ENOG4105C79 DNA protecting protein DprA HW35_16740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HW35_16745 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HW35_16750 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HW35_16755 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HW35_16760 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) HW35_16765 ENOG4105CE9 30S ribosomal protein S2 HW35_16775 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HW35_16780 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HW35_16785 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HW35_16790 ENOG4105KNE Phosphatidate cytidylyltransferase HW35_16795 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HW35_16800 ENOG4105DZP Membrane-associated zinc metalloprotease HW35_16805 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HW35_16810 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HW35_16815 ENOG4105CHV Transcription elongation factor NusA HW35_16820 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HW35_16825 ENOG4105VHM ribosomal protein HW35_16830 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HW35_16835 ENOG4105W7A Protein of unknown function (DUF503) HW35_16845 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HW35_16850 ENOG4105DTN riboflavin biosynthesis protein ribF HW35_16855 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HW35_16860 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HW35_16870 ENOG4105C1V Peptidase, M16 HW35_16880 ENOG4105E35 Dipicolinate synthase subunit A HW35_16885 ENOG4108S0H Dipicolinic acid synthetase, b subunit HW35_16890 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HW35_16900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HW35_16910 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HW35_16920 ENOG4105CNU cell division protein FtsK HW35_16925 ENOG4105FDP GntR family transcriptional regulator HW35_16930 ENOG4105DIH basic membrane HW35_16935 ENOG4108JQ9 ABC transporter HW35_16940 ENOG4105UIB (ABC) transporter HW35_16960 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HW35_16965 ENOG4105XZV Protein of unknown function (DUF3243) HW35_16980 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HW35_16985 ENOG4105CEV competence damage-inducible protein HW35_16990 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HW35_17000 ENOG4105D48 metallophosphoesterase HW35_17005 ENOG4105MCT stage V sporulation protein S HW35_17010 ENOG4105EKQ RNA-directed DNA polymerase HW35_17015 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HW35_17020 ENOG4105DQU oxidoreductase, subunit beta HW35_17025 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HW35_17045 ENOG4105DKW ABC transporter HW35_17050 ENOG4107TS3 membrane protein, TerC HW35_17060 ENOG41090MY MarR family Transcriptional regulator HW35_17065 ENOG4108VGI doxx family HW35_17070 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HW35_17075 ENOG4107XWI flavin reductase domain protein, FMN-binding HW35_17080 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HW35_17085 ENOG4105FBA Phospholipase Carboxylesterase HW35_17095 ENOG4105CS1 NAD(P)H quinone oxidoreductase HW35_17120 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HW35_17125 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HW35_17140 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HW35_17145 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HW35_17150 ENOG4106F1P AAA ATPase, central domain protein HW35_17155 ENOG4105EN6 Membrane HW35_17160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HW35_17165 ENOG4105CXI aluminum resistance protein HW35_17170 ENOG4105KV4 Transcriptional regulator HW35_17175 ENOG4105C5F glutamine synthetase HW35_17180 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HW35_17190 ENOG4108SVB resolvase HW35_17195 ENOG4105VPS UPF0291 protein HW35_17205 ENOG4105DQ6 Transposase HW35_17235 ENOG4105BZ1 (ABC) transporter HW35_17240 ENOG4105BZ1 (ABC) transporter HW35_17255 ENOG4107QIV Cytochrome c biogenesis protein HW35_17295 ENOG4105CDU Replicative dna helicase HW35_17305 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HW35_17330 ENOG4105BZJ Electron transfer flavoprotein HW35_17335 ENOG4105C10 Electron transfer flavoprotein HW35_17380 ENOG4105E1K spore germination protein HW35_17385 ENOG4108Q5U germination protein, ger(x)c family HW35_17405 ENOG4107TSN permease HW35_17415 ENOG4107RCC Major Facilitator Superfamily HW35_17430 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HW35_17435 ENOG4107RIQ Sulfate adenylate transferase HW35_17440 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HW35_17450 ENOG4105BZU Histidine kinase HW35_17480 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HW35_17490 ENOG4107RIQ Sulfate adenylate transferase HW35_17495 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HW35_17500 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HW35_17505 ENOG4105C0X amino acid HW35_17525 ENOG4108IQI permease HW35_17540 ENOG4105VEQ Cold shock protein HW35_17545 ENOG4107RFY SbcCD D subunit HW35_17550 ENOG4105EYH Exonuclease HW35_17555 ENOG4105EM7 Selenocysteine-specific translation elongation factor HW35_17560 ENOG4108ME1 Peptidase M55 D-aminopeptidase HW35_17565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HW35_17570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HW35_17575 ENOG4105C3U ABC transporter HW35_17585 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HW35_17590 ENOG4105DTQ mandelate racemase muconate lactonizing HW35_17595 ENOG4107SN7 NLP P60 protein HW35_17600 ENOG4108JQ7 (ABC) transporter HW35_17605 ENOG4108J4B Beta-lactamase HW35_17610 ENOG4105DQ6 Transposase HW35_17620 ENOG4105EYF MMPL domain protein HW35_17625 ENOG41067TZ transcriptional regulator, MarR family HW35_17645 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HW35_17685 ENOG4105G9B Transcriptional regulator HW35_17695 ENOG4105C28 cystathionine HW35_17705 ENOG4105D6E homoserine dehydrogenase