locus-tag	class	description
HW35_00015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW35_00020	COG0598	Magnesium transport protein CorA
HW35_00030	COG0861	Integral membrane protein TerC family
HW35_00035	COG1183	phosphatidylcholine synthase activity
HW35_00040	COG1132	(ABC) transporter
HW35_00065	COG0307	riboflavin synthase, alpha
HW35_00075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HW35_00085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_00090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_00095	COG1120	ATPase activity
HW35_00100	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HW35_00110	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HW35_00120	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HW35_00135	COG2096	Adenosyltransferase
HW35_00150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW35_00165	COG0697	spore germination
HW35_00175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HW35_00180	COG1247	-acetyltransferase
HW35_00195	COG1360	Flagellar Motor Protein
HW35_00200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HW35_00205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HW35_00210	COG2201	protein-glutamate methylesterase activity
HW35_00220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HW35_00225	COG4786	Flagellar basal body rod
HW35_00230	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW35_00235	COG1776	CheC inhibitor of MCP methylation
HW35_00235	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW35_00240	COG2201	protein-glutamate methylesterase activity
HW35_00245	COG0643	Histidine kinase
HW35_00245	COG2198	Histidine kinase
HW35_00250	COG0835	chemotaxis
HW35_00255	COG0835	chemotaxis
HW35_00260	COG1728	Protein conserved in bacteria
HW35_00270	COG4786	Flagellar basal body rod
HW35_00275	COG4786	Flagellar basal body rod
HW35_00280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HW35_00290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW35_00335	COG4974	Belongs to the 'phage' integrase family
HW35_00390	COG1334	flagellar protein FlaG
HW35_00400	COG0840	transmembrane signaling receptor activity
HW35_00420	COG4786	Flagellar basal body rod
HW35_00420	COG1256	bacterial-type flagellum assembly
HW35_00425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HW35_00430	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HW35_00440	COG1516	flagellar protein fliS
HW35_00460	COG1815	bacterial-type flagellum-dependent cell motility
HW35_00465	COG1558	bacterial-type flagellum-dependent cell motility
HW35_00475	COG1766	The M ring may be actively involved in energy transduction
HW35_00480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HW35_00490	COG1157	protein secretion by the type III secretion system
HW35_00510	COG1338	Plays a role in the flagellum-specific transport system
HW35_00515	COG1987	bacterial-type flagellum assembly
HW35_00520	COG1684	flagellar biosynthetic protein fliR
HW35_00525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW35_00530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HW35_00535	COG1419	protein localization to endoplasmic reticulum
HW35_00540	COG0455	bacterial-type flagellum organization
HW35_00550	COG1191	sigma factor activity
HW35_00555	COG1227	inorganic diphosphatase activity
HW35_00560	COG0519	Catalyzes the synthesis of GMP from XMP
HW35_00580	COG2217	Heavy metal translocating P-type atpase
HW35_00595	COG2608	mercury ion transmembrane transporter activity
HW35_00600	COG2801	Transposase and inactivated derivatives
HW35_00610	COG2270	Major facilitator Superfamily
HW35_00620	COG3344	reverse transcriptase
HW35_00660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HW35_00665	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HW35_00670	COG0351	phosphomethylpyrimidine kinase
HW35_00675	COG0352	thiamine-phosphate diphosphorylase activity
HW35_00685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW35_00690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW35_00695	COG1116	anion transmembrane transporter activity
HW35_00700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW35_00705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW35_00720	COG0534	Mate efflux family protein
HW35_00730	COG2267	carboxylic ester hydrolase activity
HW35_00745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW35_00790	COG0477	Major facilitator Superfamily
HW35_00800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW35_00805	COG0217	transcriptional regulatory protein
HW35_00810	COG0697	spore germination
HW35_00825	COG0456	acetyltransferase
HW35_00840	COG2135	peptidase activity
HW35_00850	COG2188	Transcriptional regulator
HW35_00855	COG0366	Alpha amylase catalytic
HW35_00860	COG1263	PTS System
HW35_00860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_00865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HW35_00880	COG2814	Major facilitator Superfamily
HW35_00885	COG0488	(ABC) transporter
HW35_00900	COG2233	PERMEase
HW35_00940	COG1921	L-seryl-tRNASec selenium transferase activity
HW35_00960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HW35_00980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_01005	COG0824	Thioesterase
HW35_01015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW35_01020	COG1832	CoA-binding protein
HW35_01025	COG0187	DNA topoisomerase II activity
HW35_01030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW35_01045	COG4974	Belongs to the 'phage' integrase family
HW35_01075	COG5577	PFAM Coat F domain
HW35_01080	COG1368	sulfuric ester hydrolase activity
HW35_01095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW35_01100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW35_01105	COG1012	belongs to the aldehyde dehydrogenase family
HW35_01110	COG3829	transcription factor binding
HW35_01115	COG3384	dioxygenase
HW35_01130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HW35_01135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HW35_01140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW35_01145	COG1012	belongs to the aldehyde dehydrogenase family
HW35_01150	COG3835	regulator
HW35_01170	COG0167	dihydroorotate dehydrogenase activity
HW35_01175	COG0493	'glutamate synthase
HW35_01180	COG1587	Uroporphyrinogen-III synthase
HW35_01185	COG2814	Major facilitator Superfamily
HW35_01200	COG2720	vancomycin resistance protein
HW35_01215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW35_01220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HW35_01225	COG0583	DNA-binding transcription factor activity
HW35_01260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW35_01265	COG0456	acetyltransferase
HW35_01265	COG0454	-acetyltransferase
HW35_01275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW35_01295	COG3647	Membrane
HW35_01305	COG3773	Cell wall hydrolase
HW35_01315	COG0653	protein targeting
HW35_01325	COG0583	DNA-binding transcription factor activity
HW35_01335	COG3773	Cell wall hydrolase
HW35_01345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW35_01350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HW35_01355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW35_01360	COG0431	NADPH-dependent FMN reductase
HW35_01380	COG0720	synthase
HW35_01390	COG2031	fatty acid transporter
HW35_01420	COG0730	response to heat
HW35_01425	COG0425	Belongs to the sulfur carrier protein TusA family
HW35_01430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW35_01430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_01440	COG0425	Belongs to the sulfur carrier protein TusA family
HW35_01440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_01445	COG2210	Belongs to the sulfur carrier protein TusA family
HW35_01450	COG1937	Protein conserved in bacteria
HW35_01485	COG1396	sequence-specific DNA binding
HW35_01485	COG3800	Transcriptional regulator
HW35_01545	COG1695	Transcriptional regulator
HW35_01555	COG0305	Participates in initiation and elongation during chromosome replication
HW35_01570	COG1309	transcriptional regulator
HW35_01580	COG2309	aminopeptidase activity
HW35_01610	COG0656	L-ascorbic acid biosynthetic process
HW35_01615	COG2814	Major facilitator Superfamily
HW35_01620	COG1733	regulation of RNA biosynthetic process
HW35_01655	COG1525	nuclease
HW35_01660	COG1316	TRANSCRIPTIONal
HW35_01665	COG0010	Belongs to the arginase family
HW35_01670	COG1228	amidohydrolase
HW35_01675	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HW35_01680	COG1757	Na H antiporter
HW35_01685	COG1418	mRNA catabolic process
HW35_01695	COG2226	methyltransferase
HW35_01715	COG2839	Protein conserved in bacteria
HW35_01765	COG3773	Cell wall hydrolase
HW35_01775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW35_01780	COG1309	transcriptional regulator
HW35_01795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HW35_01800	COG0235	Class ii aldolase
HW35_01805	COG0402	S-adenosylhomocysteine deaminase activity
HW35_01815	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HW35_01830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW35_01845	COG0697	spore germination
HW35_01865	COG1414	Transcriptional regulator
HW35_01870	COG0179	Fumarylacetoacetate (FAA) hydrolase
HW35_01875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HW35_01880	COG0277	FAD linked oxidase domain protein
HW35_01885	COG0247	lactate metabolic process
HW35_01890	COG0277	FAD linked oxidase domain protein
HW35_01895	COG0716	FMN binding
HW35_01900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW35_01905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW35_01910	COG0671	phosphoesterase, PA-phosphatase related
HW35_01925	COG0024	Methionine aminopeptidase
HW35_01940	COG1114	Component of the transport system for branched-chain amino acids
HW35_01960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW35_01965	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW35_01980	COG2027	D-alanyl-D-alanine carboxypeptidase
HW35_01985	COG3858	chitin binding
HW35_02015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW35_02015	COG0574	Belongs to the PEP-utilizing enzyme family
HW35_02020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HW35_02105	COG0708	Exodeoxyribonuclease III
HW35_02110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW35_02125	COG1657	PFAM Prenyltransferase squalene oxidase
HW35_02130	COG3850	Histidine kinase
HW35_02130	COG5002	protein histidine kinase activity
HW35_02135	COG0745	RESPONSE REGULATOR receiver
HW35_02145	COG2720	vancomycin resistance protein
HW35_02155	COG2226	methyltransferase
HW35_02165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_02180	COG2323	membrane
HW35_02185	COG0697	spore germination
HW35_02190	COG0833	amino acid
HW35_02195	COG0706	membrane insertase activity
HW35_02230	COG0017	Asparaginyl-tRNA synthetase
HW35_02245	COG3973	AAA domain
HW35_02275	COG0463	Glycosyl transferase, family 2
HW35_02275	COG0457	Tetratricopeptide repeat
HW35_02285	COG0463	Glycosyl transferase, family 2
HW35_02360	COG0527	aspartate kinase activity
HW35_02365	COG0494	nUDIX hydrolase
HW35_02370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW35_02390	COG1368	sulfuric ester hydrolase activity
HW35_02405	COG3344	reverse transcriptase
HW35_02425	COG0569	domain protein
HW35_02430	COG2223	nitrite transmembrane transporter activity
HW35_02460	COG3344	reverse transcriptase
HW35_02475	COG0488	(ABC) transporter
HW35_02490	COG4149	molybdate abc transporter
HW35_02495	COG1686	Belongs to the peptidase S11 family
HW35_02510	COG1882	Formate acetyltransferase
HW35_02515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HW35_02520	COG0706	membrane insertase activity
HW35_02530	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_02565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HW35_02565	COG0512	Glutamine amidotransferase of anthranilate synthase
HW35_02570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW35_02575	COG2814	Major facilitator Superfamily
HW35_02580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_02580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_02580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_02585	COG1105	Belongs to the carbohydrate kinase PfkB family
HW35_02590	COG1349	DNA-binding transcription factor activity
HW35_02600	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HW35_02605	COG1793	dna ligase
HW35_02605	COG3285	dna ligase
HW35_02635	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_02665	COG3409	Peptidoglycan-binding domain 1 protein
HW35_02665	COG0793	Belongs to the peptidase S41A family
HW35_02670	COG0813	purine-nucleoside phosphorylase activity
HW35_02685	COG4326	sporulation control protein
HW35_02705	COG4479	Belongs to the UPF0346 family
HW35_02715	COG1509	lysine 2,3-aminomutase activity
HW35_02720	COG3829	transcription factor binding
HW35_02725	COG0456	acetyltransferase
HW35_02730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW35_02735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HW35_02740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HW35_02745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HW35_02750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW35_02770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW35_02775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HW35_02785	COG2755	lipolytic protein G-D-S-L family
HW35_02790	COG1999	signal sequence binding
HW35_02810	COG0681	Belongs to the peptidase S26 family
HW35_02825	COG1396	sequence-specific DNA binding
HW35_02830	COG0805	protein transport
HW35_02835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW35_02845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HW35_02850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HW35_02860	COG2310	stress, protein
HW35_02865	COG2310	stress, protein
HW35_02870	COG3853	Toxic anion resistance protein (TelA)
HW35_02885	COG0861	Integral membrane protein TerC family
HW35_02890	COG2310	stress, protein
HW35_02900	COG1413	lyase activity
HW35_02905	COG0488	(ABC) transporter
HW35_02910	COG1418	mRNA catabolic process
HW35_02930	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HW35_02935	COG2801	Transposase and inactivated derivatives
HW35_02945	COG1321	iron dependent repressor
HW35_02950	COG0551	DNA topoisomerase type I activity
HW35_02950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW35_02960	COG1278	Cold shock
HW35_02970	COG0328	RNA-DNA hybrid ribonuclease activity
HW35_02985	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HW35_02995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW35_03000	COG2897	thiosulfate sulfurtransferase activity
HW35_03005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW35_03010	COG1755	Isoprenylcysteine carboxyl methyltransferase
HW35_03015	COG3424	synthase
HW35_03030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW35_03070	COG1199	ATP-dependent helicase activity
HW35_03075	COG0116	Belongs to the methyltransferase superfamily
HW35_03085	COG4474	Belongs to the UPF0398 family
HW35_03100	COG3359	exonuclease
HW35_03105	COG1111	helicase
HW35_03105	COG1205	dead DEAH box helicase
HW35_03110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW35_03115	COG0071	Belongs to the small heat shock protein (HSP20) family
HW35_03165	COG3331	DNA recombination
HW35_03175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HW35_03180	COG3935	DnaD domain protein
HW35_03205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HW35_03205	COG1199	ATP-dependent helicase activity
HW35_03210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HW35_03215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HW35_03230	COG0617	tRNA 3'-terminal CCA addition
HW35_03235	COG0438	transferase activity, transferring glycosyl groups
HW35_03240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW35_03245	COG1803	Methylglyoxal synthase
HW35_03255	COG1694	Mazg nucleotide pyrophosphohydrolase
HW35_03260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_03265	COG2738	Putative neutral zinc metallopeptidase
HW35_03275	COG4347	Protein of unknown function (DUF1405)
HW35_03285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HW35_03300	COG5582	Belongs to the UPF0302 family
HW35_03305	COG0457	Tetratricopeptide repeat
HW35_03315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HW35_03320	COG0287	Prephenate dehydrogenase
HW35_03325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HW35_03330	COG4401	Chorismate mutase type I
HW35_03335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HW35_03345	COG0105	UTP biosynthetic process
HW35_03350	COG0142	geranyltranstransferase activity
HW35_03355	COG2226	methyltransferase
HW35_03360	COG0142	geranyltranstransferase activity
HW35_03370	COG0302	gtp cyclohydrolase
HW35_03375	COG0776	regulation of translation
HW35_03380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HW35_03400	COG1160	GTP binding
HW35_03420	COG1304	FMN binding
HW35_03425	COG0539	negative regulation of cytoplasmic translation
HW35_03435	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HW35_03445	COG2959	enzyme of heme biosynthesis
HW35_03450	COG3409	Peptidoglycan-binding domain 1 protein
HW35_03450	COG3773	Cell wall hydrolase
HW35_03455	COG2339	peptidase activity
HW35_03465	COG0492	ferredoxin-NADP+ reductase activity
HW35_03470	COG3344	reverse transcriptase
HW35_03475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW35_03480	COG4862	establishment of competence for transformation
HW35_03495	COG3546	catalase activity
HW35_03510	COG1266	CAAX protease self-immunity
HW35_03515	COG0514	ATP-dependent DNA helicase (RecQ)
HW35_03520	COG4955	Helix-turn-helix domain
HW35_03530	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HW35_03535	COG3942	CHAP domain
HW35_03535	COG1388	LysM domain
HW35_03545	COG1595	DNA-templated transcription, initiation
HW35_03555	COG5002	protein histidine kinase activity
HW35_03560	COG0745	RESPONSE REGULATOR receiver
HW35_03565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW35_03570	COG1333	cytochrome c biogenesis protein
HW35_03575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_03580	COG1187	pseudouridine synthase activity
HW35_03585	COG0700	Nucleoside recognition
HW35_03590	COG2715	membrane protein required for spore maturation
HW35_03595	COG1686	Belongs to the peptidase S11 family
HW35_03600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HW35_03615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HW35_03620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HW35_03630	COG1547	Domain of unknown function (DUF309)
HW35_03640	COG4086	secreted protein
HW35_03650	COG0697	spore germination
HW35_03675	COG2172	sigma factor antagonist activity
HW35_03685	COG1686	Belongs to the peptidase S11 family
HW35_03705	COG4974	Belongs to the 'phage' integrase family
HW35_03720	COG0735	belongs to the Fur family
HW35_03725	COG1300	Membrane
HW35_03735	COG2801	Transposase and inactivated derivatives
HW35_03740	COG1379	DNA repair
HW35_03755	COG0667	Aldo Keto reductase
HW35_03765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW35_03775	COG1073	alpha beta
HW35_03800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW35_03810	COG0300	oxidoreductase activity
HW35_03815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW35_03820	COG1902	pentaerythritol trinitrate reductase activity
HW35_03825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HW35_03830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HW35_03835	COG1234	tRNA 3'-trailer cleavage
HW35_03840	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW35_03845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW35_03850	COG0346	lactoylglutathione lyase activity
HW35_03865	COG1703	isobutyryl-CoA mutase activity
HW35_03870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_03870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_03875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_03880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW35_03885	COG0022	dehydrogenase e1 component
HW35_03890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HW35_03895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HW35_03910	COG0280	phosphate acetyltransferase
HW35_03915	COG3290	protein histidine kinase activity
HW35_03915	COG3829	transcription factor binding
HW35_03930	COG0584	glycerophosphoryl diester phosphodiesterase
HW35_03940	COG0750	zinc metalloprotease
HW35_03945	COG0497	DNA recombination
HW35_03950	COG1438	arginine binding
HW35_03965	COG1722	exodeoxyribonuclease VII activity
HW35_03970	COG1570	exodeoxyribonuclease VII activity
HW35_03975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HW35_03985	COG1302	Protein conserved in bacteria
HW35_03990	COG0439	Biotin carboxylase
HW35_03995	COG0511	ligase activity, forming carbon-carbon bonds
HW35_04040	COG3854	ATPases associated with a variety of cellular activities
HW35_04060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HW35_04065	COG0006	proline dipeptidase activity
HW35_04075	COG3872	metal-dependent enzyme
HW35_04085	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW35_04105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HW35_04120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HW35_04135	COG0095	Lipoate-protein ligase
HW35_04140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_04145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW35_04150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HW35_04155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HW35_04160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW35_04190	COG4970	Tfp pilus assembly protein FimT
HW35_04195	COG4537	Required for transformation and DNA binding
HW35_04205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW35_04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW35_04240	COG1940	carbohydrate kinase activity
HW35_04245	COG4483	Protein conserved in bacteria
HW35_04265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HW35_04270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HW35_04290	COG0704	Plays a role in the regulation of phosphate uptake
HW35_04305	COG0573	inorganic phosphate transmembrane transporter activity
HW35_04310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HW35_04320	COG0477	Major facilitator Superfamily
HW35_04330	COG5521	maltodextrose utilization protein MalA
HW35_04340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HW35_04345	COG4709	membrane
HW35_04350	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HW35_04355	COG0735	belongs to the Fur family
HW35_04360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HW35_04365	COG1121	(ABC) transporter
HW35_04375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HW35_04380	COG0513	Belongs to the DEAD box helicase family
HW35_04390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HW35_04395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW35_04400	COG2384	SAM-dependent methyltransferase
HW35_04405	COG2010	Cytochrome c
HW35_04410	COG1960	acyl-CoA dehydrogenase activity
HW35_04415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HW35_04420	COG0358	DNA primase activity
HW35_04425	COG1671	Belongs to the UPF0178 family
HW35_04435	COG0517	IMP dehydrogenase activity
HW35_04445	COG2801	Transposase and inactivated derivatives
HW35_04450	COG0423	glycine-tRNA ligase activity
HW35_04455	COG1381	Involved in DNA repair and RecF pathway recombination
HW35_04465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HW35_04470	COG0295	cytidine deaminase activity
HW35_04475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HW35_04485	COG1480	7TM receptor with intracellular HD hydrolase
HW35_04490	COG1702	phosphate starvation-inducible protein PhoH
HW35_04505	COG1610	YqeY-like protein
HW35_04510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HW35_04520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW35_04525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HW35_04530	COG2264	protein methyltransferase activity
HW35_04535	COG0484	heat shock protein binding
HW35_04540	COG0443	Heat shock 70 kDa protein
HW35_04545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HW35_04555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW35_04560	COG0481	GTPase activity
HW35_04570	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW35_04580	COG0268	Binds directly to 16S ribosomal RNA
HW35_04590	COG1466	dna polymerase III delta subunit
HW35_04600	COG0658	competence protein
HW35_04600	COG2333	competence protein COMEC
HW35_04605	COG2131	deaminase
HW35_04610	COG1555	photosystem II stabilization
HW35_04610	COG1596	polysaccharide export
HW35_04615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HW35_04620	COG3344	reverse transcriptase
HW35_04625	COG2226	methyltransferase
HW35_04630	COG0799	negative regulation of ribosome biogenesis
HW35_04635	COG1713	HD superfamily hydrolase involved in NAD metabolism
HW35_04640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HW35_04645	COG1534	Rna-binding protein
HW35_04655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HW35_04660	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HW35_04670	COG0688	phosphatidylethanolamine metabolic process
HW35_04675	COG1183	phosphatidylcholine synthase activity
HW35_04705	COG0626	cystathionine gamma-synthase activity
HW35_04710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW35_04715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HW35_04725	COG0768	penicillin binding
HW35_04730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HW35_04735	COG0572	uridine kinase
HW35_04755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HW35_04760	COG3906	Belongs to the UPF0473 family
HW35_04765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HW35_04770	COG4472	Bacterial protein of unknown function (DUF965)
HW35_04775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HW35_04780	COG0628	permease
HW35_04800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HW35_04815	COG1104	cysteine desulfurase activity
HW35_04820	COG1959	2 iron, 2 sulfur cluster binding
HW35_04825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HW35_04835	COG4841	protein insertion into membrane
HW35_04840	COG1879	ABC-type sugar transport system periplasmic component
HW35_04845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW35_04850	COG1129	ABC transporter
HW35_04855	COG1869	D-ribose catabolic process
HW35_04860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW35_04865	COG1609	Transcriptional regulator
HW35_04870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HW35_04875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HW35_04880	COG0124	histidyl-tRNA synthetase
HW35_04890	COG3103	Sh3 type 3 domain protein
HW35_04890	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW35_04890	COG4991	sh3 domain protein
HW35_04895	COG1490	D-aminoacyl-tRNA deacylase activity
HW35_04900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HW35_04905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW35_04910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HW35_04910	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HW35_04920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW35_04920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HW35_04930	COG2244	polysaccharide biosynthetic process
HW35_04935	COG2323	membrane
HW35_04945	COG1862	Preprotein translocase
HW35_04955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HW35_04965	COG2255	four-way junction helicase activity
HW35_04970	COG0632	four-way junction helicase activity
HW35_04995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HW35_05000	COG0157	Belongs to the NadC ModD family
HW35_05005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HW35_05010	COG1104	cysteine desulfurase activity
HW35_05015	COG1827	regulation of RNA biosynthetic process
HW35_05020	COG0077	Prephenate dehydratase
HW35_05025	COG4492	Belongs to the UPF0735 family
HW35_05030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HW35_05035	COG3290	protein histidine kinase activity
HW35_05040	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HW35_05045	COG2868	ribosomal protein
HW35_05050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HW35_05055	COG1530	ribonuclease E activity
HW35_05060	COG1994	Peptidase M50
HW35_05065	COG0739	heme binding
HW35_05070	COG2894	cell division
HW35_05085	COG1792	Involved in formation and maintenance of cell shape
HW35_05090	COG1077	Cell shape determining protein MreB Mrl
HW35_05095	COG2003	Belongs to the UPF0758 family
HW35_05135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HW35_05160	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HW35_05170	COG3706	GGDEF domain
HW35_05175	COG0285	dihydrofolate synthase activity
HW35_05195	COG1388	LysM domain
HW35_05195	COG1388	LysM domain
HW35_05210	COG3344	reverse transcriptase
HW35_05215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW35_05220	COG0113	porphobilinogen synthase activity
HW35_05230	COG0181	hydroxymethylbilane synthase activity
HW35_05235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HW35_05255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HW35_05260	COG1067	ATP-dependent peptidase activity
HW35_05260	COG0470	DNA polymerase III
HW35_05270	COG0544	peptidyl-prolyl cis-trans isomerase activity
HW35_05290	COG1131	(ABC) transporter
HW35_05325	COG2801	Transposase and inactivated derivatives
HW35_05345	COG0622	Phosphoesterase
HW35_05350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HW35_05355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HW35_05360	COG5401	PFAM Sporulation and spore germination
HW35_05370	COG1846	Transcriptional regulator
HW35_05375	COG3344	reverse transcriptase
HW35_05400	COG2197	response regulator
HW35_05405	COG3764	Sortase (surface protein transpeptidase)
HW35_05410	COG3344	reverse transcriptase
HW35_05415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HW35_05420	COG1053	succinate dehydrogenase
HW35_05425	COG2009	succinate dehydrogenase
HW35_05430	COG1719	4-vinyl reductase, 4VR
HW35_05440	COG0322	excinuclease ABC activity
HW35_05445	COG3118	belongs to the thioredoxin family
HW35_05455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW35_05460	COG2086	electron transfer activity
HW35_05465	COG1024	Enoyl-CoA hydratase
HW35_05470	COG1309	transcriptional regulator
HW35_05475	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_05480	COG3766	membrane
HW35_05485	COG1193	negative regulation of DNA recombination
HW35_05490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HW35_05490	COG1796	DNA polymerase
HW35_05495	COG1286	toxin biosynthetic process
HW35_05500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HW35_05525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HW35_05525	COG0072	phenylalanine-tRNA ligase activity
HW35_05530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HW35_05535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW35_05545	COG1363	Peptidase, m42
HW35_05555	COG3326	Membrane
HW35_05560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HW35_05565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HW35_05570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HW35_05575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW35_05585	COG1484	DNA-dependent DNA replication
HW35_05590	COG3611	Membrane attachment protein
HW35_05595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HW35_05605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW35_05610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HW35_05615	COG0237	dephospho-CoA kinase activity
HW35_05620	COG1971	Probably functions as a manganese efflux pump
HW35_05625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HW35_05630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW35_05630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HW35_05640	COG0745	RESPONSE REGULATOR receiver
HW35_05645	COG3344	reverse transcriptase
HW35_05660	COG0039	L-malate dehydrogenase activity
HW35_05665	COG0538	isocitrate dehydrogenase activity
HW35_05670	COG0372	Belongs to the citrate synthase family
HW35_05675	COG2707	UPF0756 membrane protein
HW35_05680	COG0628	permease
HW35_05690	COG0205	6-phosphofructokinase activity
HW35_05695	COG0825	malonyl-CoA metabolic process
HW35_05700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HW35_05705	COG2186	Transcriptional regulator
HW35_05710	COG0281	malic enzyme
HW35_05715	COG0587	DNA-directed DNA polymerase activity
HW35_05730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HW35_05740	COG4109	DRTGG domain
HW35_05750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HW35_05755	COG0006	proline dipeptidase activity
HW35_05775	COG0589	response to stress
HW35_05795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HW35_05800	COG0827	DNA restriction-modification system
HW35_05805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HW35_05810	COG3874	Sporulation protein YtfJ
HW35_05825	COG0616	signal peptide processing
HW35_05830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW35_05835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW35_05850	COG0301	tRNA thio-modification
HW35_05855	COG1104	cysteine desulfurase activity
HW35_05860	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HW35_05865	COG1309	transcriptional regulator
HW35_05870	COG1956	GAF domain-containing protein
HW35_05885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HW35_05895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HW35_05900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HW35_05905	COG0454	-acetyltransferase
HW35_05910	COG0517	IMP dehydrogenase activity
HW35_05915	COG0123	including yeast histone deacetylase and acetoin utilization protein
HW35_05920	COG1609	Transcriptional regulator
HW35_05925	COG1605	Chorismate mutase
HW35_05925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HW35_05930	COG3118	belongs to the thioredoxin family
HW35_05945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HW35_05950	COG1674	ftsk spoiiie
HW35_05955	COG4848	Belongs to the UPF0354 family
HW35_05960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_05965	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HW35_05970	COG1363	Peptidase, m42
HW35_05980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HW35_05985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HW35_05995	COG0510	thiamine kinase activity
HW35_06000	COG1523	belongs to the glycosyl hydrolase 13 family
HW35_06005	COG1597	lipid kinase activity
HW35_06015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW35_06045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HW35_06055	COG1349	DNA-binding transcription factor activity
HW35_06065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW35_06080	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HW35_06085	COG0783	Belongs to the Dps family
HW35_06090	COG1187	pseudouridine synthase activity
HW35_06095	COG2244	polysaccharide biosynthetic process
HW35_06100	COG2081	HI0933 family
HW35_06110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HW35_06115	COG0495	leucyl-tRNA aminoacylation
HW35_06120	COG2814	Major facilitator Superfamily
HW35_06135	COG1242	4 iron, 4 sulfur cluster binding
HW35_06140	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HW35_06150	COG2267	carboxylic ester hydrolase activity
HW35_06155	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HW35_06160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HW35_06175	COG1506	peptidase
HW35_06180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HW35_06185	COG1116	anion transmembrane transporter activity
HW35_06190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HW35_06195	COG0450	alkyl hydroperoxide reductase
HW35_06205	COG0561	phosphatase activity
HW35_06235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_06255	COG2801	Transposase and inactivated derivatives
HW35_06270	COG1131	(ABC) transporter
HW35_06315	COG2252	PERMEase
HW35_06320	COG1404	Belongs to the peptidase S8 family
HW35_06325	COG1279	arginine transmembrane transporter activity
HW35_06330	COG0494	nUDIX hydrolase
HW35_06350	COG1854	S-ribosylhomocysteine lyase activity
HW35_06355	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HW35_06360	COG0288	reversible hydration of carbon dioxide
HW35_06375	COG4948	Mandelate Racemase Muconate Lactonizing
HW35_06380	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_06385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HW35_06390	COG0596	Alpha beta hydrolase
HW35_06395	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HW35_06400	COG1169	isochorismate synthase
HW35_06405	COG1575	Belongs to the MenA family. Type 1 subfamily
HW35_06410	COG0058	SHG alpha-glucan phosphorylase activity
HW35_06415	COG0297	glycogen (starch) synthase activity
HW35_06420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HW35_06555	COG1285	pathogenesis
HW35_06565	COG3162	membrane
HW35_06570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW35_06590	COG0083	homoserine kinase activity
HW35_06595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HW35_06600	COG0460	homoserine dehydrogenase
HW35_06605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HW35_06615	COG0840	transmembrane signaling receptor activity
HW35_06625	COG3773	Cell wall hydrolase
HW35_06630	COG0783	Belongs to the Dps family
HW35_06640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HW35_06645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HW35_06650	COG2706	6-phosphogluconolactonase activity
HW35_06655	COG0626	cystathionine gamma-synthase activity
HW35_06660	COG0626	cystathionine gamma-synthase activity
HW35_06665	COG0646	methionine synthase
HW35_06665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HW35_06670	COG0646	methionine synthase
HW35_06670	COG1410	methionine synthase
HW35_06680	COG2814	Major facilitator Superfamily
HW35_06685	COG0492	ferredoxin-NADP+ reductase activity
HW35_06690	COG0346	lactoylglutathione lyase activity
HW35_06700	COG2801	Transposase and inactivated derivatives
HW35_06730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW35_06745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HW35_06755	COG1113	amino acid transport
HW35_06760	COG1280	lysine exporter protein (LysE YggA)
HW35_06765	COG0463	Glycosyl transferase, family 2
HW35_06805	COG1979	alcohol dehydrogenase
HW35_06815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW35_06825	COG1098	S1 RNA binding domain
HW35_06840	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HW35_06850	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HW35_06870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HW35_06880	COG5018	Exonuclease
HW35_06885	COG2050	protein possibly involved in aromatic compounds catabolism
HW35_06895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HW35_06900	COG3584	3D domain protein
HW35_06915	COG1252	NADH dehydrogenase
HW35_06935	COG0316	Belongs to the HesB IscA family
HW35_06940	COG4844	belongs to the
HW35_06945	COG1252	NADH dehydrogenase
HW35_06950	COG4837	Protein of unknown function (DUF1462)
HW35_06955	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HW35_06960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW35_06965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_06970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HW35_06975	COG0647	UMP catabolic process
HW35_06980	COG2445	Protein of unknown function DUF86
HW35_06995	COG4470	Protein conserved in bacteria
HW35_07005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HW35_07010	COG0739	heme binding
HW35_07020	COG3377	Domain of unknown function (DUF1805)
HW35_07025	COG0730	response to heat
HW35_07030	COG1801	Protein of unknown function DUF72
HW35_07055	COG0719	Fe-S assembly protein
HW35_07060	COG0822	iron-sulfur transferase activity
HW35_07065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HW35_07070	COG0719	Fe-S assembly protein
HW35_07075	COG0396	ATPase activity
HW35_07080	COG1464	Belongs to the NlpA lipoprotein family
HW35_07085	COG2011	ABC-type metal ion transport system permease component
HW35_07090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HW35_07120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HW35_07125	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HW35_07130	COG0509	glycine decarboxylation via glycine cleavage system
HW35_07135	COG1393	Belongs to the ArsC family
HW35_07150	COG1960	acyl-CoA dehydrogenase activity
HW35_07155	COG0183	Belongs to the thiolase family
HW35_07160	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW35_07160	COG1024	Enoyl-CoA hydratase
HW35_07180	COG1120	ATPase activity
HW35_07185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_07190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_07195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_07200	COG0772	Belongs to the SEDS family
HW35_07215	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_07220	COG2268	Band 7 protein
HW35_07225	COG1585	Membrane protein implicated in regulation of membrane protease activity
HW35_07235	COG1126	abc transporter atp-binding protein
HW35_07240	COG0765	amino acid transport
HW35_07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_07250	COG0531	amino acid
HW35_07255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HW35_07260	COG1607	acyl-coa hydrolase
HW35_07275	COG0628	permease
HW35_07355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HW35_07360	COG0557	exoribonuclease II activity
HW35_07365	COG1647	Serine aminopeptidase, S33
HW35_07370	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW35_07395	COG0148	phosphopyruvate hydratase activity
HW35_07400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HW35_07410	COG0126	phosphoglycerate kinase activity
HW35_07430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HW35_07440	COG4641	Protein conserved in bacteria
HW35_07445	COG1086	Polysaccharide biosynthesis protein
HW35_07450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HW35_07455	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HW35_07460	COG3980	spore coat polysaccharide biosynthesis protein
HW35_07470	COG2089	acid synthase
HW35_07475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HW35_07480	COG0463	Glycosyl transferase, family 2
HW35_07485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HW35_07495	COG1091	dTDP-4-dehydrorhamnose reductase activity
HW35_07510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW35_07515	COG3002	Belongs to the UPF0753 family
HW35_07520	COG0288	reversible hydration of carbon dioxide
HW35_07525	COG5609	conserved protein (DUF2294)
HW35_07540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HW35_07545	COG0569	domain protein
HW35_07590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_07600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HW35_07605	COG1660	Displays ATPase and GTPase activities
HW35_07610	COG1051	belongs to the nudix hydrolase family
HW35_07615	COG0492	ferredoxin-NADP+ reductase activity
HW35_07620	COG0457	Tetratricopeptide repeat
HW35_07630	COG0140	phosphoribosyl-ATP diphosphatase activity
HW35_07630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HW35_07635	COG0107	imidazoleglycerol-phosphate synthase activity
HW35_07640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HW35_07645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HW35_07650	COG0131	Imidazoleglycerol-phosphate dehydratase
HW35_07660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HW35_07665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HW35_07670	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HW35_07675	COG0110	maltose O-acetyltransferase activity
HW35_07685	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HW35_07695	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HW35_07700	COG1950	PFAM Membrane protein of
HW35_07705	COG3595	metallopeptidase activity
HW35_07710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HW35_07715	COG0556	nucleotide-excision repair
HW35_07720	COG4897	Protein conserved in bacteria
HW35_07725	COG1115	amino acid carrier protein
HW35_07730	COG3876	Protein conserved in bacteria
HW35_07735	COG1472	Belongs to the glycosyl hydrolase 3 family
HW35_07740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW35_07765	COG1737	Transcriptional regulator
HW35_07775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW35_07790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_07795	COG0765	amino acid transport
HW35_07800	COG1126	abc transporter atp-binding protein
HW35_07815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW35_07820	COG3409	Peptidoglycan-binding domain 1 protein
HW35_07820	COG0793	Belongs to the peptidase S41A family
HW35_07825	COG0739	heme binding
HW35_07830	COG2177	Part of the ABC transporter FtsEX involved in
HW35_07835	COG2884	Cell division ATP-binding protein ftsE
HW35_07845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_07850	COG3344	reverse transcriptase
HW35_07855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HW35_07860	COG0653	protein targeting
HW35_07870	COG2801	Transposase and inactivated derivatives
HW35_07885	COG1040	competence protein
HW35_07890	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HW35_07895	COG1307	EDD domain protein, DegV family
HW35_07900	COG2197	response regulator
HW35_07905	COG4585	Histidine kinase
HW35_07910	COG1739	Uncharacterized protein family UPF0029
HW35_07915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW35_07950	COG2801	Transposase and inactivated derivatives
HW35_07960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW35_07965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW35_07980	COG0438	transferase activity, transferring glycosyl groups
HW35_07990	COG2246	polysaccharide biosynthetic process
HW35_08005	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HW35_08025	COG4750	Nucleotidyl transferase
HW35_08035	COG4750	Nucleotidyl transferase
HW35_08045	COG0697	spore germination
HW35_08065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW35_08085	COG3853	Toxic anion resistance protein (TelA)
HW35_08090	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HW35_08095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HW35_08105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW35_08140	COG0243	molybdopterin cofactor binding
HW35_08150	COG1301	dicarboxylic acid transport
HW35_08170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HW35_08180	COG2252	PERMEase
HW35_08205	COG1522	sequence-specific DNA binding
HW35_08210	COG0436	Aminotransferase
HW35_08235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HW35_08240	COG2971	BadF BadG BcrA BcrD
HW35_08265	COG4821	SIS domain
HW35_08365	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HW35_08370	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HW35_08375	COG1609	Transcriptional regulator
HW35_08390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HW35_08400	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HW35_08410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_08415	COG0110	maltose O-acetyltransferase activity
HW35_08435	COG0778	Nitroreductase
HW35_08460	COG2822	iron ion transport
HW35_08465	COG2837	iron assimilation
HW35_08470	COG0672	)-iron permease
HW35_08495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW35_08525	COG1131	(ABC) transporter
HW35_08545	COG3037	sugar-specific permease SgaT UlaA
HW35_08555	COG3711	transcriptional antiterminator
HW35_08570	COG1136	(ABC) transporter
HW35_08610	COG1556	Lactate utilization protein
HW35_08615	COG1139	Iron-sulfur cluster binding protein
HW35_08620	COG0247	lactate metabolic process
HW35_08625	COG2186	Transcriptional regulator
HW35_08630	COG1620	l-lactate permease
HW35_08635	COG0277	FAD linked oxidase domain protein
HW35_08640	COG0247	lactate metabolic process
HW35_08655	COG1404	Belongs to the peptidase S8 family
HW35_08675	COG1191	sigma factor activity
HW35_08705	COG1482	cell wall glycoprotein biosynthetic process
HW35_08710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_08710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_08710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HW35_08715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_08715	COG3711	transcriptional antiterminator
HW35_08720	COG1940	carbohydrate kinase activity
HW35_08740	COG2801	Transposase and inactivated derivatives
HW35_08770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW35_08780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HW35_08800	COG0438	transferase activity, transferring glycosyl groups
HW35_08810	COG0587	DNA-directed DNA polymerase activity
HW35_08815	COG0438	transferase activity, transferring glycosyl groups
HW35_08825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HW35_08830	COG4464	protein tyrosine phosphatase activity
HW35_08835	COG0489	protein tyrosine kinase activity
HW35_08840	COG3944	biosynthesis protein
HW35_08850	COG2801	Transposase and inactivated derivatives
HW35_08870	COG0791	NLP P60 protein
HW35_08870	COG1388	LysM domain
HW35_08885	COG0662	Cupin 2, conserved barrel domain protein
HW35_08890	COG4715	Zinc finger, swim domain protein
HW35_08895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HW35_08905	COG3584	3D domain protein
HW35_08905	COG1388	LysM domain
HW35_08915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_08920	COG0765	amino acid transport
HW35_08925	COG1126	abc transporter atp-binding protein
HW35_08935	COG0629	single-stranded DNA binding
HW35_08965	COG1077	Cell shape determining protein MreB Mrl
HW35_08970	COG1609	Transcriptional regulator
HW35_08975	COG0768	penicillin binding
HW35_08985	COG0739	heme binding
HW35_08995	COG2385	sporulation resulting in formation of a cellular spore
HW35_09015	COG4836	Membrane
HW35_09025	COG1007	ATP synthesis coupled electron transport
HW35_09030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_09035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HW35_09045	COG0839	Belongs to the complex I subunit 6 family
HW35_09055	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HW35_09060	COG0649	NAD binding
HW35_09065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_09070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_09075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HW35_09080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HW35_09085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HW35_09090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HW35_09095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HW35_09105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HW35_09110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HW35_09115	COG0356	it plays a direct role in the translocation of protons across the membrane
HW35_09135	COG1404	Belongs to the peptidase S8 family
HW35_09140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HW35_09155	COG0698	ribose 5-phosphate isomerase
HW35_09165	COG1971	Probably functions as a manganese efflux pump
HW35_09170	COG0009	L-threonylcarbamoyladenylate synthase
HW35_09185	COG2890	protein-(glutamine-N5) methyltransferase activity
HW35_09190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HW35_09200	COG1435	thymidine kinase activity
HW35_09210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HW35_09215	COG1494	fructose-1,6-bisphosphatase
HW35_09220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HW35_09225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HW35_09230	COG0191	fructose-bisphosphate aldolase activity
HW35_09235	COG2204	response regulator
HW35_09240	COG4821	SIS domain
HW35_09245	COG0504	CTP synthase activity
HW35_09250	COG3343	RNA polymerase activity
HW35_09260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_09260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HW35_09260	COG1703	isobutyryl-CoA mutase activity
HW35_09270	COG1960	acyl-CoA dehydrogenase activity
HW35_09275	COG1960	acyl-CoA dehydrogenase activity
HW35_09280	COG1250	3-hydroxyacyl-CoA dehydrogenase
HW35_09285	COG0183	Belongs to the thiolase family
HW35_09290	COG0247	lactate metabolic process
HW35_09290	COG2181	nitrate reductase activity
HW35_09295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW35_09300	COG3344	reverse transcriptase
HW35_09310	COG0018	arginyl-trna synthetase
HW35_09315	COG4506	Protein conserved in bacteria
HW35_09320	COG0010	Belongs to the arginase family
HW35_09325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HW35_09330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HW35_09340	COG1994	Peptidase M50
HW35_09350	COG3465	dGTPase activity
HW35_09355	COG1078	dGTPase activity
HW35_09360	COG4844	belongs to the
HW35_09370	COG0095	Lipoate-protein ligase
HW35_09395	COG0280	phosphate acetyltransferase
HW35_09410	COG2363	Small membrane protein
HW35_09420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW35_09435	COG0314	molybdopterin synthase activity
HW35_09445	COG0351	phosphomethylpyrimidine kinase
HW35_09450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HW35_09460	COG1113	amino acid transport
HW35_09495	COG1131	(ABC) transporter
HW35_09505	COG0561	phosphatase activity
HW35_09540	COG0559	Belongs to the binding-protein-dependent transport system permease family
HW35_09550	COG0477	Major facilitator Superfamily
HW35_09555	COG1132	(ABC) transporter
HW35_09560	COG1132	(ABC) transporter
HW35_09570	COG2195	Cleaves the N-terminal amino acid of tripeptides
HW35_09575	COG0069	glutamate synthase activity
HW35_09580	COG0583	DNA-binding transcription factor activity
HW35_09585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HW35_09620	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HW35_09700	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW35_09705	COG1122	ATPase activity
HW35_09715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HW35_09730	COG0183	Belongs to the thiolase family
HW35_09735	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_09740	COG1268	BioY protein
HW35_09745	COG3344	reverse transcriptase
HW35_09750	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW35_09765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HW35_09780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HW35_09785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HW35_09790	COG4853	Protein conserved in bacteria
HW35_09795	COG4863	YycH protein
HW35_09800	COG5002	protein histidine kinase activity
HW35_09805	COG0745	RESPONSE REGULATOR receiver
HW35_09810	COG0741	lytic transglycosylase activity
HW35_09810	COG1196	nuclear chromosome segregation
HW35_09810	COG0739	heme binding
HW35_09845	COG0305	Participates in initiation and elongation during chromosome replication
HW35_09855	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HW35_09875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HW35_09880	COG0629	single-stranded DNA binding
HW35_09885	COG0360	Binds together with S18 to 16S ribosomal RNA
HW35_09890	COG0012	GTP binding
HW35_09895	COG0243	molybdopterin cofactor binding
HW35_09900	COG4481	Protein conserved in bacteria
HW35_09905	COG0668	transmembrane transport
HW35_09920	COG1475	DNA binding
HW35_09925	COG1192	Involved in chromosome partitioning
HW35_09930	COG1475	DNA binding
HW35_09935	COG0357	Ribosomal RNA small subunit methyltransferase G
HW35_09945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HW35_09950	COG1847	R3H domain protein
HW35_09960	COG0594	ribonuclease P activity
HW35_09970	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HW35_09975	COG0592	DNA-directed DNA polymerase activity
HW35_09980	COG2501	S4 domain
HW35_09985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HW35_09995	COG0187	DNA topoisomerase II activity
HW35_10000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HW35_10040	COG0517	IMP dehydrogenase activity
HW35_10040	COG0516	GMP reductase activity
HW35_10055	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HW35_10070	COG1428	Deoxynucleoside kinase
HW35_10075	COG1428	Deoxynucleoside kinase
HW35_10080	COG1388	LysM domain
HW35_10080	COG3858	chitin binding
HW35_10085	COG0590	tRNA wobble adenosine to inosine editing
HW35_10090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HW35_10100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HW35_10145	COG1982	Orn Lys Arg decarboxylase major
HW35_10150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HW35_10155	COG3870	Protein conserved in bacteria
HW35_10160	COG0470	DNA polymerase III
HW35_10165	COG1774	PSP1 C-terminal conserved region
HW35_10170	COG4467	Involved in initiation control of chromosome replication
HW35_10175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HW35_10180	COG2827	Endonuclease containing a URI domain
HW35_10185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HW35_10190	COG2002	toxin-antitoxin pair type II binding
HW35_10205	COG0084	hydrolase, TatD family'
HW35_10210	COG3583	domain protein
HW35_10210	COG3584	3D domain protein
HW35_10220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HW35_10230	COG4466	Protein conserved in bacteria
HW35_10245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HW35_10250	COG0251	oxidation-reduction process
HW35_10255	COG2088	sporulation resulting in formation of a cellular spore
HW35_10260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HW35_10265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HW35_10270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HW35_10275	COG0193	aminoacyl-tRNA hydrolase activity
HW35_10285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HW35_10290	COG2002	toxin-antitoxin pair type II binding
HW35_10295	COG2244	polysaccharide biosynthetic process
HW35_10300	COG3956	TIGRFAM MazG family protein
HW35_10305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HW35_10325	COG1098	S1 RNA binding domain
HW35_10335	COG2208	phosphoserine phosphatase activity
HW35_10340	COG2304	oxidoreductase activity
HW35_10345	COG0515	serine threonine protein kinase
HW35_10360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW35_10365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HW35_10370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HW35_10375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW35_10385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HW35_10390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HW35_10395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HW35_10400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HW35_10405	COG1396	sequence-specific DNA binding
HW35_10410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HW35_10420	COG3226	Transcriptional regulator
HW35_10570	COG3880	PFAM UvrB UvrC protein
HW35_10575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HW35_10580	COG0542	response to heat
HW35_10585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HW35_10590	COG4956	integral membrane protein (PIN domain superfamily)
HW35_10595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HW35_10600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HW35_10605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HW35_10610	COG1045	serine acetyltransferase
HW35_10615	COG0215	cysteine-tRNA ligase activity
HW35_10625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HW35_10630	COG3688	RNA-binding protein containing a PIN domain
HW35_10640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HW35_10645	COG0250	Participates in transcription elongation, termination and antitermination
HW35_10650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HW35_10655	COG0081	regulation of translation
HW35_10660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HW35_10665	COG0222	ribosome binding
HW35_10670	COG2813	Specifically methylates the guanine in position
HW35_10675	COG0085	RNA polymerase activity
HW35_10685	COG1358	cellular component organization or biogenesis
HW35_10690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HW35_10695	COG0049	tRNA binding
HW35_10700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HW35_10705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HW35_10710	COG0051	transcription antitermination factor activity, RNA binding
HW35_10715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HW35_10720	COG0088	Forms part of the polypeptide exit tunnel
HW35_10730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HW35_10735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HW35_10740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HW35_10745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HW35_10750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HW35_10755	COG0255	Belongs to the universal ribosomal protein uL29 family
HW35_10765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HW35_10770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HW35_10775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HW35_10780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HW35_10790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HW35_10795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HW35_10800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HW35_10805	COG1841	ribosomal large subunit assembly
HW35_10810	COG0200	Binds to the 23S rRNA
HW35_10815	COG0201	protein transport
HW35_10820	COG0563	adenylate kinase activity
HW35_10825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HW35_10830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HW35_10835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HW35_10840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HW35_10845	COG0202	RNA polymerase activity
HW35_10850	COG0203	ribosomal protein L17
HW35_10855	COG1122	ATPase activity
HW35_10860	COG1122	ATPase activity
HW35_10865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HW35_10870	COG0101	tRNA pseudouridine synthase activity
HW35_10875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HW35_10880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HW35_10925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW35_10930	COG1136	(ABC) transporter
HW35_10935	COG0577	efflux transmembrane transporter activity
HW35_10965	COG0860	N-Acetylmuramoyl-L-alanine amidase
HW35_10970	COG0489	protein tyrosine kinase activity
HW35_10985	COG0726	polysaccharide deacetylase
HW35_11065	COG1595	DNA-templated transcription, initiation
HW35_11070	COG5662	AntiSigma factor
HW35_11075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HW35_11080	COG4856	YbbR-like protein
HW35_11085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW35_11095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HW35_11130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HW35_11140	COG1388	LysM domain
HW35_11155	COG0398	Pfam SNARE associated Golgi protein
HW35_11160	COG0745	RESPONSE REGULATOR receiver
HW35_11165	COG5002	protein histidine kinase activity
HW35_11180	COG3711	transcriptional antiterminator
HW35_11180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_11185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW35_11190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HW35_11195	COG1447	Phosphotransferase system cellobiose-specific component IIA
HW35_11200	COG2723	6-phospho-beta-galactosidase activity
HW35_11225	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HW35_11230	COG1846	Transcriptional regulator
HW35_11255	COG3711	transcriptional antiterminator
HW35_11275	COG3655	Transcriptional regulator
HW35_11295	COG0693	protein deglycase activity
HW35_11300	COG2409	Drug exporters of the RND superfamily
HW35_11330	COG1309	transcriptional regulator
HW35_11340	COG0018	arginyl-trna synthetase
HW35_11350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HW35_11355	COG2076	Multidrug Resistance protein
HW35_11360	COG2076	Multidrug Resistance protein
HW35_11365	COG0586	Pfam SNARE associated Golgi protein
HW35_11370	COG0772	Belongs to the SEDS family
HW35_11375	COG2239	Acts as a magnesium transporter
HW35_11385	COG1181	Belongs to the D-alanine--D-alanine ligase family
HW35_11390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HW35_11405	COG0705	Rhomboid family
HW35_11410	COG0736	holo-[acyl-carrier-protein] synthase activity
HW35_11415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HW35_11425	COG0864	Transcriptional regulator
HW35_11430	COG2337	Toxic component of a toxin-antitoxin (TA) module
HW35_11445	COG2183	response to ionizing radiation
HW35_11455	COG3091	SprT-like family
HW35_11535	COG0802	atpase or kinase
HW35_11540	COG1214	PFAM Peptidase M22, glycoprotease
HW35_11545	COG0456	acetyltransferase
HW35_11555	COG0488	(ABC) transporter
HW35_11565	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HW35_11575	COG1266	CAAX protease self-immunity
HW35_11580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HW35_11590	COG1940	carbohydrate kinase activity
HW35_11600	COG2814	Major facilitator Superfamily
HW35_11600	COG0477	Major facilitator Superfamily
HW35_11605	COG1070	Carbohydrate kinase
HW35_11625	COG0730	response to heat
HW35_11630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HW35_11630	COG0519	Catalyzes the synthesis of GMP from XMP
HW35_11635	COG2252	PERMEase
HW35_11640	COG3711	transcriptional antiterminator
HW35_11645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_11645	COG1263	PTS System
HW35_11645	COG2190	(PTS) system
HW35_11680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HW35_11685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HW35_11690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HW35_11695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HW35_11700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW35_11705	COG0047	phosphoribosylformylglycinamidine synthase activity
HW35_11710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HW35_11715	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HW35_11720	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HW35_11725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HW35_11730	COG0138	bifunctional purine biosynthesis protein purh
HW35_11735	COG0151	Belongs to the GarS family
HW35_11750	COG1470	cell adhesion involved in biofilm formation
HW35_11755	COG4496	protein, YerC YecD
HW35_11760	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HW35_11765	COG0210	DNA helicase
HW35_11770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HW35_11775	COG4851	CamS sex pheromone cAM373 precursor
HW35_11780	COG1012	belongs to the aldehyde dehydrogenase family
HW35_11785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HW35_11790	COG2146	nitrite reductase [NAD(P)H] activity
HW35_11805	COG2224	Isocitrate lyase
HW35_11810	COG1764	response to oxidative stress
HW35_11820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW35_11825	COG0154	amidase activity
HW35_11830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HW35_11840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW35_11845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HW35_11855	COG1597	lipid kinase activity
HW35_11860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HW35_11930	COG0109	protoheme IX farnesyltransferase activity
HW35_11945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HW35_11950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HW35_11970	COG1253	flavin adenine dinucleotide binding
HW35_11975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HW35_11975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW35_11985	COG1263	PTS System
HW35_11985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_11990	COG3711	transcriptional antiterminator
HW35_12005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_12010	COG4605	iron ion homeostasis
HW35_12015	COG4604	ABC transporter, ATP-binding protein
HW35_12020	COG4607	ABC-type enterochelin transport system periplasmic component
HW35_12025	COG2329	Antibiotic biosynthesis monooxygenase
HW35_12030	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HW35_12035	COG1268	BioY protein
HW35_12040	COG1115	amino acid carrier protein
HW35_12055	COG0346	lactoylglutathione lyase activity
HW35_12060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HW35_12065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HW35_12070	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HW35_12075	COG2017	converts alpha-aldose to the beta-anomer
HW35_12080	COG1609	Transcriptional regulator
HW35_12090	COG2972	Histidine kinase
HW35_12095	COG2201	protein-glutamate methylesterase activity
HW35_12110	COG1129	ABC transporter
HW35_12115	COG4211	Belongs to the binding-protein-dependent transport system permease family
HW35_12120	COG1725	Transcriptional regulator
HW35_12125	COG1131	(ABC) transporter
HW35_12135	COG1595	DNA-templated transcription, initiation
HW35_12150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HW35_12175	COG1620	l-lactate permease
HW35_12190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HW35_12215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW35_12220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_12225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HW35_12230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HW35_12235	COG1120	ATPase activity
HW35_12245	COG2318	DinB family
HW35_12250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW35_12255	COG3344	reverse transcriptase
HW35_12270	COG1136	(ABC) transporter
HW35_12275	COG0642	Histidine kinase
HW35_12280	COG0745	RESPONSE REGULATOR receiver
HW35_12285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HW35_12290	COG1823	symporter activity
HW35_12295	COG0494	nUDIX hydrolase
HW35_12310	COG0673	inositol 2-dehydrogenase activity
HW35_12325	COG0194	GDP metabolic process
HW35_12350	COG2205	protein histidine kinase activity
HW35_12365	COG0583	DNA-binding transcription factor activity
HW35_12380	COG3250	beta-galactosidase activity
HW35_12400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HW35_12405	COG0765	amino acid transport
HW35_12410	COG0765	amino acid transport
HW35_12415	COG2801	Transposase and inactivated derivatives
HW35_12430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HW35_12435	COG2022	thiamine diphosphate biosynthetic process
HW35_12445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW35_12450	COG0352	thiamine-phosphate diphosphorylase activity
HW35_12470	COG0577	efflux transmembrane transporter activity
HW35_12470	COG1136	(ABC) transporter
HW35_12480	COG1388	LysM domain
HW35_12480	COG3584	3D domain protein
HW35_12490	COG0475	glutathione-regulated potassium exporter activity
HW35_12510	COG0673	inositol 2-dehydrogenase activity
HW35_12515	COG1129	ABC transporter
HW35_12520	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW35_12525	COG1879	ABC-type sugar transport system periplasmic component
HW35_12530	COG1609	Transcriptional regulator
HW35_12535	COG0673	inositol 2-dehydrogenase activity
HW35_12550	COG3962	Belongs to the TPP enzyme family
HW35_12555	COG1082	Xylose isomerase domain protein TIM barrel
HW35_12560	COG0191	fructose-bisphosphate aldolase activity
HW35_12565	COG3718	enzyme involved in inositol metabolism
HW35_12575	COG0494	nUDIX hydrolase
HW35_12585	COG0500	methyltransferase
HW35_12590	COG1073	alpha beta
HW35_12600	COG1609	Transcriptional regulator
HW35_12610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HW35_12625	COG4145	pantothenate transmembrane transporter activity
HW35_12630	COG0517	IMP dehydrogenase activity
HW35_12635	COG2340	Cysteine-rich secretory protein family
HW35_12655	COG2807	transmembrane transport
HW35_12680	COG3844	kynureninase activity
HW35_12695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HW35_12710	COG1136	(ABC) transporter
HW35_12735	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_12740	COG1169	isochorismate synthase
HW35_12745	COG3433	isochorismatase activity
HW35_12745	COG1535	isochorismatase
HW35_12755	COG1021	2,3-dihydroxybenzoate-AMP ligase
HW35_12760	COG1535	isochorismatase
HW35_12760	COG3433	isochorismatase activity
HW35_12765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HW35_12830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW35_12830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HW35_12835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW35_12835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HW35_12850	COG2258	MOSC domain
HW35_12875	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HW35_12890	COG0716	FMN binding
HW35_12900	COG0432	Pfam Uncharacterised protein family UPF0047
HW35_12920	COG0733	neurotransmitter:sodium symporter activity
HW35_12925	COG1051	belongs to the nudix hydrolase family
HW35_12930	COG2814	Major facilitator Superfamily
HW35_12955	COG2832	Protein of unknown function (DUF454)
HW35_12980	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HW35_12985	COG3483	tryptophan 2,3-dioxygenase activity
HW35_12990	COG1113	amino acid transport
HW35_12995	COG1309	transcriptional regulator
HW35_13010	COG2368	4-hydroxyphenylacetate
HW35_13015	COG0431	NADPH-dependent FMN reductase
HW35_13030	COG0251	oxidation-reduction process
HW35_13060	COG1027	Aspartate ammonia-lyase
HW35_13065	COG0582	viral genome integration into host DNA
HW35_13070	COG0490	domain, Protein
HW35_13075	COG0475	glutathione-regulated potassium exporter activity
HW35_13080	COG1414	Transcriptional regulator
HW35_13105	COG2176	DNA-directed DNA polymerase activity
HW35_13125	COG2346	COG2346, Truncated hemoglobins
HW35_13130	COG1653	transport
HW35_13145	COG1609	Transcriptional regulator
HW35_13155	COG0673	inositol 2-dehydrogenase activity
HW35_13160	COG0673	inositol 2-dehydrogenase activity
HW35_13175	COG0366	Alpha amylase catalytic
HW35_13195	COG3832	glyoxalase III activity
HW35_13215	COG0166	Belongs to the GPI family
HW35_13220	COG3189	MarR family transcriptional regulator
HW35_13225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_13230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HW35_13235	COG3414	Phosphotransferase system galactitol-specific IIB component
HW35_13240	COG3775	system Galactitol-specific IIC component
HW35_13245	COG1063	alcohol dehydrogenase
HW35_13260	COG0456	acetyltransferase
HW35_13270	COG2801	Transposase and inactivated derivatives
HW35_13275	COG0066	3-isopropylmalate dehydratase activity
HW35_13280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HW35_13285	COG0473	3-isopropylmalate dehydrogenase activity
HW35_13290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HW35_13295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HW35_13300	COG0440	acetolactate synthase activity
HW35_13305	COG0028	Belongs to the TPP enzyme family
HW35_13310	COG0129	dihydroxy-acid dehydratase activity
HW35_13325	COG0789	Transcriptional regulator
HW35_13340	COG0765	amino acid transport
HW35_13345	COG1126	abc transporter atp-binding protein
HW35_13360	COG0183	Belongs to the thiolase family
HW35_13375	COG0514	ATP-dependent DNA helicase (RecQ)
HW35_13380	COG0535	radical SAM domain protein
HW35_13385	COG2814	Major facilitator Superfamily
HW35_13395	COG1129	ABC transporter
HW35_13400	COG1172	Belongs to the binding-protein-dependent transport system permease family
HW35_13410	COG1966	Carbon starvation protein
HW35_13415	COG2966	Psort location CytoplasmicMembrane, score
HW35_13425	COG3275	phosphorelay sensor kinase activity
HW35_13435	COG1966	Carbon starvation protein
HW35_13440	COG0531	amino acid
HW35_13445	COG2801	Transposase and inactivated derivatives
HW35_13455	COG5002	protein histidine kinase activity
HW35_13460	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HW35_13460	COG2199	diguanylate cyclase activity
HW35_13475	COG0243	molybdopterin cofactor binding
HW35_13505	COG4585	Histidine kinase
HW35_13510	COG2197	response regulator
HW35_13535	COG1114	Component of the transport system for branched-chain amino acids
HW35_13565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW35_13580	COG0723	plastoquinol--plastocyanin reductase activity
HW35_13580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW35_13615	COG2197	response regulator
HW35_13620	COG2244	polysaccharide biosynthetic process
HW35_13625	COG2801	Transposase and inactivated derivatives
HW35_13630	COG0670	Belongs to the BI1 family
HW35_13635	COG1970	mechanosensitive ion channel activity
HW35_13640	COG2309	aminopeptidase activity
HW35_13650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW35_13650	COG0551	DNA topoisomerase type I activity
HW35_13655	COG2986	histidine ammonia-lyase
HW35_13690	COG0024	Methionine aminopeptidase
HW35_13695	COG4840	Belongs to the UPF0435 family
HW35_13705	COG1295	ribonuclease BN
HW35_13715	COG2801	Transposase and inactivated derivatives
HW35_13725	COG2217	Heavy metal translocating P-type atpase
HW35_13730	COG0477	Major facilitator Superfamily
HW35_13740	COG0387	Pfam Sodium calcium exchanger
HW35_13770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HW35_13800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HW35_13805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HW35_13810	COG0640	Transcriptional regulator
HW35_13820	COG1695	Transcriptional regulator
HW35_13835	COG1695	Transcriptional regulator
HW35_13850	COG2207	Transcriptional regulator
HW35_13850	COG3708	Transcriptional regulator
HW35_13865	COG1929	Belongs to the glycerate kinase type-1 family
HW35_13880	COG0039	L-malate dehydrogenase activity
HW35_13885	COG1620	l-lactate permease
HW35_13890	COG1846	Transcriptional regulator
HW35_13890	COG0456	acetyltransferase
HW35_13900	COG1533	DNA photolyase activity
HW35_13920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW35_13925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HW35_13940	COG1960	acyl-CoA dehydrogenase activity
HW35_13945	COG0784	Response regulator, receiver
HW35_13950	COG4191	Histidine kinase
HW35_13965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_13970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_13990	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HW35_14020	COG1518	maintenance of DNA repeat elements
HW35_14025	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HW35_14040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HW35_14050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HW35_14055	COG1140	nitrate reductase beta subunit
HW35_14060	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HW35_14065	COG2181	nitrate reductase activity
HW35_14075	COG2066	Belongs to the glutaminase family
HW35_14085	COG0789	Transcriptional regulator
HW35_14090	COG0444	Belongs to the ABC transporter superfamily
HW35_14095	COG4608	Belongs to the ABC transporter superfamily
HW35_14100	COG0747	negative chemotaxis
HW35_14115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HW35_14120	COG0710	3-dehydroquinate dehydratase activity
HW35_14125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HW35_14130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HW35_14135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HW35_14140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HW35_14145	COG0505	Belongs to the CarA family
HW35_14150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HW35_14155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HW35_14160	COG0137	argininosuccinate synthase activity
HW35_14165	COG0165	Argininosuccinate lyase
HW35_14170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HW35_14170	COG3153	acetyltransferase
HW35_14175	COG0456	acetyltransferase
HW35_14195	COG2137	regulation of response to DNA damage stimulus
HW35_14205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HW35_14215	COG0300	oxidoreductase activity
HW35_14235	COG1988	membrane-bound metal-dependent
HW35_14240	COG1194	a g-specific adenine glycosylase
HW35_14250	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_14270	COG1132	(ABC) transporter
HW35_14275	COG4129	membrane
HW35_14280	COG0069	glutamate synthase activity
HW35_14280	COG0070	glutamate synthase
HW35_14280	COG0067	glutamate synthase
HW35_14285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HW35_14290	COG4555	ABC transporter
HW35_14310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HW35_14315	COG2096	Adenosyltransferase
HW35_14320	COG0735	belongs to the Fur family
HW35_14420	COG4974	Belongs to the 'phage' integrase family
HW35_14435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW35_14450	COG1674	ftsk spoiiie
HW35_14530	COG0071	Belongs to the small heat shock protein (HSP20) family
HW35_14555	COG3382	B3 4 domain protein
HW35_14560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HW35_14565	COG2801	Transposase and inactivated derivatives
HW35_14590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HW35_14600	COG2766	serine protein kinase
HW35_14610	COG1263	PTS System
HW35_14610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HW35_14610	COG2190	(PTS) system
HW35_14615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HW35_14620	COG0363	glucosamine-6-phosphate deaminase activity
HW35_14630	COG2340	Cysteine-rich secretory protein family
HW35_14645	COG5002	protein histidine kinase activity
HW35_14665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HW35_14670	COG0306	phosphate transporter
HW35_14675	COG1392	Phosphate transport regulator
HW35_14680	COG2261	transglycosylase associated protein
HW35_14685	COG0564	pseudouridine synthase activity
HW35_14695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HW35_14715	COG2719	SpoVR family
HW35_14720	COG0686	Belongs to the AlaDH PNT family
HW35_14725	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW35_14725	COG2508	Transcriptional regulator
HW35_14735	COG3344	reverse transcriptase
HW35_14740	COG2733	membrane
HW35_14745	COG4841	protein insertion into membrane
HW35_14770	COG1253	flavin adenine dinucleotide binding
HW35_14775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HW35_14780	COG3852	Histidine kinase
HW35_14785	COG3859	Proton-coupled thiamine transporter YuaJ
HW35_14805	COG3842	ATPase activity
HW35_14810	COG2508	Transcriptional regulator
HW35_14830	COG0189	ligase activity
HW35_14835	COG0189	ligase activity
HW35_14845	COG3679	Belongs to the UPF0342 family
HW35_14850	COG0561	phosphatase activity
HW35_14855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HW35_14860	COG1024	Enoyl-CoA hydratase
HW35_14870	COG4152	abc transporter atp-binding protein
HW35_14875	COG1668	transmembrane transport
HW35_14880	COG0420	3'-5' exonuclease activity
HW35_14885	COG4717	serine-type aminopeptidase activity
HW35_14890	COG3481	metal-dependent phosphohydrolase, HD sub domain
HW35_14900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HW35_14920	COG1846	Transcriptional regulator
HW35_14935	COG0537	adenosine 5'-monophosphoramidase activity
HW35_14945	COG1131	(ABC) transporter
HW35_14950	COG4473	ABC transporter
HW35_14965	COG3069	C4-dicarboxylate transmembrane transporter activity
HW35_14975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HW35_14990	COG1511	domain protein
HW35_14995	COG1234	tRNA 3'-trailer cleavage
HW35_15000	COG0095	Lipoate-protein ligase
HW35_15005	COG0318	PFAM AMP-dependent synthetase and ligase
HW35_15010	COG1024	Enoyl-CoA hydratase
HW35_15015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HW35_15025	COG0501	Belongs to the peptidase M48B family
HW35_15050	COG1316	TRANSCRIPTIONal
HW35_15055	COG0398	Pfam SNARE associated Golgi protein
HW35_15065	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HW35_15070	COG1074	ATP-dependent DNA helicase activity
HW35_15115	COG0367	asparagine synthase
HW35_15125	COG1666	GTP binding
HW35_15130	COG2996	Protein conserved in bacteria
HW35_15140	COG3344	reverse transcriptase
HW35_15145	COG1307	EDD domain protein, DegV family
HW35_15175	COG0561	phosphatase activity
HW35_15180	COG2151	metal-sulfur cluster biosynthetic enzyme
HW35_15195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HW35_15200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HW35_15205	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HW35_15210	COG0303	'Molybdopterin
HW35_15215	COG1763	Mo-molybdopterin cofactor biosynthetic process
HW35_15225	COG0542	response to heat
HW35_15235	COG2267	carboxylic ester hydrolase activity
HW35_15245	COG1744	ABC transporter substrate-binding protein PnrA-like
HW35_15250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW35_15255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HW35_15260	COG5504	Zn-dependent protease
HW35_15265	COG0444	Belongs to the ABC transporter superfamily
HW35_15270	COG4608	Belongs to the ABC transporter superfamily
HW35_15280	COG0601	transmembrane transport
HW35_15285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW35_15295	COG0180	Tryptophanyl-tRNA synthetase
HW35_15310	COG0601	transmembrane transport
HW35_15315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW35_15320	COG0444	Belongs to the ABC transporter superfamily
HW35_15325	COG4608	Belongs to the ABC transporter superfamily
HW35_15335	COG1393	Belongs to the ArsC family
HW35_15345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HW35_15355	COG1164	Oligoendopeptidase f
HW35_15370	COG2346	COG2346, Truncated hemoglobins
HW35_15375	COG4116	CYTH
HW35_15385	COG2357	RelA SpoT domain protein
HW35_15390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HW35_15395	COG0564	pseudouridine synthase activity
HW35_15400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HW35_15405	COG0569	domain protein
HW35_15405	COG0475	glutathione-regulated potassium exporter activity
HW35_15410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HW35_15450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HW35_15465	COG2153	protein acetylation
HW35_15470	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HW35_15475	COG2382	esterase
HW35_15515	COG2801	Transposase and inactivated derivatives
HW35_15525	COG0725	ABC transporter, periplasmic molybdate-binding protein
HW35_15540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HW35_15545	COG1136	(ABC) transporter
HW35_15550	COG0577	efflux transmembrane transporter activity
HW35_15555	COG3344	reverse transcriptase
HW35_15565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HW35_15570	COG0512	Glutamine amidotransferase of anthranilate synthase
HW35_15575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HW35_15595	COG1968	undecaprenyl-diphosphatase activity
HW35_15610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HW35_15620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HW35_15625	COG1191	sigma factor activity
HW35_15660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW35_15665	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW35_15670	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HW35_15675	COG0436	Aminotransferase
HW35_15685	COG1850	ribulose-bisphosphate carboxylase activity
HW35_15690	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HW35_15695	COG0235	Class ii aldolase
HW35_15700	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HW35_15710	COG0644	oxidoreductase
HW35_15720	COG0204	Acyl-transferase
HW35_15725	COG3949	Membrane
HW35_15730	COG0542	response to heat
HW35_15745	COG1846	Transcriptional regulator
HW35_15750	COG3852	Histidine kinase
HW35_15755	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HW35_15775	COG4873	Protein conserved in bacteria
HW35_15785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HW35_15795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HW35_15800	COG2084	Dehydrogenase
HW35_15815	COG2801	Transposase and inactivated derivatives
HW35_15820	COG0436	Aminotransferase
HW35_15830	COG5001	Diguanylate cyclase
HW35_15830	COG3300	MHYT domain
HW35_15860	COG1408	metallophosphoesterase
HW35_15865	COG2200	EAL domain
HW35_15875	COG4703	Protein of unknown function (DUF1797)
HW35_15880	COG0517	IMP dehydrogenase activity
HW35_15885	COG0477	Major facilitator Superfamily
HW35_15890	COG0583	DNA-binding transcription factor activity
HW35_15895	COG2171	N-acyltransferase activity
HW35_15900	COG1473	amidohydrolase
HW35_15905	COG0569	domain protein
HW35_15910	COG2801	Transposase and inactivated derivatives
HW35_15915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW35_15940	COG0508	dehydrogenase complex catalyzes the overall conversion of
HW35_15965	COG1982	Orn Lys Arg decarboxylase major
HW35_15975	COG4476	Belongs to the UPF0223 family
HW35_16000	COG4493	Belongs to the UPF0637 family
HW35_16010	COG0483	inositol monophosphate 1-phosphatase activity
HW35_16035	COG4896	Protein conserved in bacteria
HW35_16050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HW35_16055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HW35_16065	COG0772	Belongs to the SEDS family
HW35_16070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HW35_16080	COG2801	Transposase and inactivated derivatives
HW35_16090	COG0109	protoheme IX farnesyltransferase activity
HW35_16115	COG3336	cytochrome c oxidase
HW35_16130	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HW35_16135	COG2340	Cysteine-rich secretory protein family
HW35_16165	COG3679	Belongs to the UPF0342 family
HW35_16170	COG4471	UPF0298 protein
HW35_16180	COG2801	Transposase and inactivated derivatives
HW35_16185	COG0742	ribosomal rna small subunit methyltransferase
HW35_16190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HW35_16205	COG3314	Sporulation integral membrane protein YlbJ
HW35_16210	COG1752	Esterase of the alpha-beta hydrolase superfamily
HW35_16215	COG3480	Lon protease (S16) C-terminal proteolytic domain
HW35_16220	COG1323	Belongs to the UPF0348 family
HW35_16225	COG1399	metal-binding, possibly nucleic acid-binding protein
HW35_16230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HW35_16235	COG1024	Enoyl-CoA hydratase
HW35_16245	COG0454	-acetyltransferase
HW35_16250	COG0439	Biotin carboxylase
HW35_16255	COG0511	ligase activity, forming carbon-carbon bonds
HW35_16260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HW35_16265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HW35_16275	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HW35_16280	COG2001	Belongs to the MraZ family
HW35_16290	COG4839	cell division protein FtsL
HW35_16300	COG0768	penicillin binding
HW35_16305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HW35_16315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HW35_16320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HW35_16325	COG0772	Belongs to the SEDS family
HW35_16330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HW35_16335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HW35_16340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HW35_16345	COG3879	Bacterial protein of unknown function (DUF881)
HW35_16350	COG3879	Bacterial protein of unknown function (DUF881)
HW35_16355	COG3856	small basic protein
HW35_16360	COG0849	cell division
HW35_16365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HW35_16375	COG3344	reverse transcriptase
HW35_16385	COG1191	sigma factor activity
HW35_16395	COG1191	sigma factor activity
HW35_16400	COG1873	PFAM PRC-barrel domain
HW35_16410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HW35_16415	COG1799	cell septum assembly
HW35_16420	COG0762	integral membrane protein
HW35_16425	COG2302	S4 RNA-binding domain
HW35_16430	COG3599	regulation of cell shape
HW35_16435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HW35_16450	COG0564	pseudouridine synthase activity
HW35_16455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HW35_16470	COG0540	Belongs to the ATCase OTCase family
HW35_16495	COG0167	dihydroorotate dehydrogenase activity
HW35_16500	COG0284	orotidine-5'-phosphate decarboxylase activity
HW35_16515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HW35_16520	COG1561	YicC-like family, N-terminal region
HW35_16525	COG2052	Domain of unknown function (DUF370)
HW35_16530	COG0194	GDP metabolic process
HW35_16540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW35_16545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HW35_16550	COG0242	peptide deformylase activity
HW35_16555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HW35_16560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HW35_16560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HW35_16565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HW35_16570	COG0631	protein serine/threonine phosphatase activity
HW35_16575	COG2815	serine threonine protein kinase
HW35_16575	COG0515	serine threonine protein kinase
HW35_16580	COG1162	GTPase activity
HW35_16585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HW35_16590	COG1564	THIamine pyrophosphokinase
HW35_16600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HW35_16605	COG1302	Protein conserved in bacteria
HW35_16610	COG1461	Dihydroxyacetone kinase
HW35_16615	COG1760	l-serine dehydratase
HW35_16620	COG1760	l-serine dehydratase
HW35_16625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HW35_16630	COG1349	DNA-binding transcription factor activity
HW35_16640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HW35_16645	COG1028	Short-chain dehydrogenase reductase Sdr
HW35_16650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HW35_16655	COG0571	ribonuclease III activity
HW35_16660	COG1196	nuclear chromosome segregation
HW35_16665	COG0552	protein localization to endoplasmic reticulum
HW35_16670	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HW35_16675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HW35_16685	COG1837	Belongs to the UPF0109 family
HW35_16695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HW35_16700	COG0336	Belongs to the RNA methyltransferase TrmD family
HW35_16705	COG0335	large ribosomal subunit rRNA binding
HW35_16725	COG0045	succinate-CoA ligase (ADP-forming) activity
HW35_16730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HW35_16735	COG0758	DNA mediated transformation
HW35_16740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HW35_16745	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HW35_16750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HW35_16755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HW35_16760	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HW35_16765	COG0052	Belongs to the universal ribosomal protein uS2 family
HW35_16775	COG0528	UMP kinase activity
HW35_16780	COG0233	cytoplasmic translational termination
HW35_16785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HW35_16790	COG4589	Belongs to the CDS family
HW35_16795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HW35_16800	COG0750	zinc metalloprotease
HW35_16805	COG2176	DNA-directed DNA polymerase activity
HW35_16810	COG0779	Required for maturation of 30S ribosomal subunits
HW35_16815	COG0195	Participates in both transcription termination and antitermination
HW35_16820	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HW35_16825	COG1358	cellular component organization or biogenesis
HW35_16830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HW35_16835	COG1550	Protein conserved in bacteria
HW35_16845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HW35_16850	COG0196	riboflavin kinase activity
HW35_16855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HW35_16860	COG1185	polyribonucleotide nucleotidyltransferase activity
HW35_16865	COG0726	polysaccharide deacetylase
HW35_16870	COG0612	Peptidase, M16
HW35_16875	COG1873	PFAM PRC-barrel domain
HW35_16880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HW35_16885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HW35_16890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HW35_16895	COG0527	aspartate kinase activity
HW35_16905	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HW35_16910	COG0740	serine-type endopeptidase activity
HW35_16920	COG1674	ftsk spoiiie
HW35_16920	COG4980	gas vesicle protein
HW35_16925	COG2188	Transcriptional regulator
HW35_16950	COG0612	Peptidase, M16
HW35_16955	COG0612	Peptidase, M16
HW35_16960	COG0300	oxidoreductase activity
HW35_16975	COG1426	Protein conserved in bacteria
HW35_16980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HW35_16985	COG1546	Belongs to the CinA family
HW35_16985	COG1058	Belongs to the CinA family
HW35_16990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HW35_17000	COG1692	metallophosphoesterase
HW35_17005	COG2359	stage V sporulation protein S
HW35_17010	COG3344	reverse transcriptase
HW35_17015	COG0674	pyruvate-flavodoxin oxidoreductase activity
HW35_17015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HW35_17020	COG1013	pyruvate-flavodoxin oxidoreductase activity
HW35_17025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HW35_17030	COG4550	Control of competence regulator ComK, YlbF/YmcA
HW35_17045	COG1119	ATPase activity
HW35_17050	COG0861	Integral membrane protein TerC family
HW35_17060	COG1846	Transcriptional regulator
HW35_17065	COG2259	Doxx family
HW35_17070	COG0346	lactoylglutathione lyase activity
HW35_17075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HW35_17080	COG0346	lactoylglutathione lyase activity
HW35_17085	COG0400	carboxylic ester hydrolase activity
HW35_17090	COG2259	Doxx family
HW35_17095	COG0655	NAD(P)H dehydrogenase (quinone) activity
HW35_17120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HW35_17125	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HW35_17135	COG1077	Cell shape determining protein MreB Mrl
HW35_17140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HW35_17145	COG1923	regulation of RNA biosynthetic process
HW35_17150	COG0464	growth
HW35_17155	COG2860	membrane
HW35_17160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HW35_17165	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HW35_17170	COG0789	Transcriptional regulator
HW35_17175	COG0174	glutamine synthetase
HW35_17180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HW35_17190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HW35_17195	COG4224	UPF0291 protein
HW35_17205	COG2801	Transposase and inactivated derivatives
HW35_17215	COG3763	UPF0154 protein
HW35_17235	COG1132	(ABC) transporter
HW35_17240	COG1132	(ABC) transporter
HW35_17255	COG0785	Cytochrome C biogenesis protein
HW35_17265	COG4846	Membrane protein involved in cytochrome C biogenesis
HW35_17295	COG0305	Participates in initiation and elongation during chromosome replication
HW35_17305	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HW35_17335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HW35_17380	COG0697	spore germination
HW35_17405	COG0730	response to heat
HW35_17415	COG2814	Major facilitator Superfamily
HW35_17430	COG0175	sulfate reduction
HW35_17435	COG2046	Belongs to the sulfate adenylyltransferase family
HW35_17440	COG0529	Catalyzes the synthesis of activated sulfate
HW35_17445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HW35_17450	COG4191	Histidine kinase
HW35_17480	COG0175	sulfate reduction
HW35_17485	COG0306	phosphate transporter
HW35_17490	COG2046	Belongs to the sulfate adenylyltransferase family
HW35_17495	COG0529	Catalyzes the synthesis of activated sulfate
HW35_17505	COG0531	amino acid
HW35_17515	COG0656	L-ascorbic acid biosynthetic process
HW35_17525	COG0833	amino acid
HW35_17540	COG1278	Cold shock
HW35_17545	COG0420	3'-5' exonuclease activity
HW35_17550	COG0419	ATPase involved in DNA repair
HW35_17560	COG2362	D-Aminopeptidase
HW35_17565	COG0601	transmembrane transport
HW35_17570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HW35_17575	COG0444	Belongs to the ABC transporter superfamily
HW35_17580	COG4166	transmembrane transport
HW35_17585	COG1619	proteins homologs of microcin C7 resistance protein MccF
HW35_17590	COG4948	Mandelate Racemase Muconate Lactonizing
HW35_17595	COG0791	NLP P60 protein
HW35_17600	COG4608	Belongs to the ABC transporter superfamily
HW35_17610	COG2801	Transposase and inactivated derivatives
HW35_17620	COG1033	growth of symbiont in host cell
HW35_17620	COG2409	Drug exporters of the RND superfamily
HW35_17625	COG1846	Transcriptional regulator
HW35_17645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HW35_17670	COG1473	amidohydrolase
HW35_17675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HW35_17680	COG0006	proline dipeptidase activity
HW35_17685	COG2508	Transcriptional regulator
HW35_17690	COG2423	ornithine cyclodeaminase activity
HW35_17710	COG1012	belongs to the aldehyde dehydrogenase family
HW35_17715	COG0006	proline dipeptidase activity