locus-tag	class	description
CS527_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CS527_00010	COG0592	DNA-directed DNA polymerase activity
CS527_00015	COG2501	S4 domain
CS527_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CS527_00025	COG0187	DNA topoisomerase II activity
CS527_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CS527_00065	COG0516	GMP reductase activity
CS527_00065	COG0517	IMP dehydrogenase activity
CS527_00080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CS527_00095	COG1428	Deoxynucleoside kinase
CS527_00100	COG1428	Deoxynucleoside kinase
CS527_00105	COG3858	chitin binding
CS527_00105	COG1388	LysM domain
CS527_00110	COG1335	isochorismatase
CS527_00115	COG0590	tRNA wobble adenosine to inosine editing
CS527_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CS527_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CS527_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CS527_00240	COG1982	Orn Lys Arg decarboxylase major
CS527_00245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CS527_00250	COG3870	Protein conserved in bacteria
CS527_00255	COG0470	DNA polymerase III
CS527_00260	COG1774	PSP1 C-terminal conserved region
CS527_00265	COG4467	Involved in initiation control of chromosome replication
CS527_00270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CS527_00275	COG2827	Endonuclease containing a URI domain
CS527_00280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CS527_00285	COG2002	toxin-antitoxin pair type II binding
CS527_00295	COG0084	hydrolase, TatD family'
CS527_00305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CS527_00315	COG4466	Protein conserved in bacteria
CS527_00330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS527_00335	COG0251	oxidation-reduction process
CS527_00340	COG2088	sporulation resulting in formation of a cellular spore
CS527_00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CS527_00350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CS527_00360	COG0193	aminoacyl-tRNA hydrolase activity
CS527_00370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CS527_00380	COG2002	toxin-antitoxin pair type II binding
CS527_00385	COG2244	polysaccharide biosynthetic process
CS527_00390	COG3956	TIGRFAM MazG family protein
CS527_00395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CS527_00410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CS527_00415	COG1098	S1 RNA binding domain
CS527_00435	COG2304	oxidoreductase activity
CS527_00440	COG0515	serine threonine protein kinase
CS527_00445	COG0037	tRNA processing
CS527_00455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CS527_00460	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CS527_00465	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CS527_00470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS527_00475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CS527_00480	COG0512	Glutamine amidotransferase of anthranilate synthase
CS527_00485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS527_00490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CS527_00495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CS527_00500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CS527_00525	COG3880	PFAM UvrB UvrC protein
CS527_00530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CS527_00535	COG0542	response to heat
CS527_00540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CS527_00545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CS527_00550	COG4956	integral membrane protein (PIN domain superfamily)
CS527_00555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CS527_00565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CS527_00570	COG1045	serine acetyltransferase
CS527_00575	COG0215	cysteine-tRNA ligase activity
CS527_00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS527_00590	COG3688	RNA-binding protein containing a PIN domain
CS527_00600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CS527_00605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CS527_00610	COG0250	Participates in transcription elongation, termination and antitermination
CS527_00620	COG0081	regulation of translation
CS527_00625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CS527_00635	COG2813	Specifically methylates the guanine in position
CS527_00640	COG0085	RNA polymerase activity
CS527_00650	COG1358	cellular component organization or biogenesis
CS527_00655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CS527_00660	COG0049	tRNA binding
CS527_00670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CS527_00675	COG0051	transcription antitermination factor activity, RNA binding
CS527_00680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CS527_00685	COG0088	Forms part of the polypeptide exit tunnel
CS527_00690	COG0089	rRNA binding
CS527_00695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CS527_00700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CS527_00705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CS527_00710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CS527_00715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CS527_00720	COG0255	Belongs to the universal ribosomal protein uL29 family
CS527_00725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CS527_00730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CS527_00745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CS527_00765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CS527_00770	COG1841	ribosomal large subunit assembly
CS527_00780	COG0201	protein transport
CS527_00785	COG0563	adenylate kinase activity
CS527_00790	COG0024	Methionine aminopeptidase
CS527_00795	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CS527_00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CS527_00805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CS527_00815	COG0202	RNA polymerase activity
CS527_00820	COG0203	ribosomal protein L17
CS527_00825	COG1122	ATPase activity
CS527_00830	COG1122	ATPase activity
CS527_00835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CS527_00840	COG0101	tRNA pseudouridine synthase activity
CS527_00845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CS527_00860	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_00865	COG0489	protein tyrosine kinase activity
CS527_00870	COG0583	DNA-binding transcription factor activity
CS527_00880	COG2194	sulfuric ester hydrolase activity
CS527_00885	COG0726	polysaccharide deacetylase
CS527_00965	COG1595	DNA-templated transcription, initiation
CS527_00970	COG5662	AntiSigma factor
CS527_00975	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS527_00985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS527_00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CS527_01005	COG3103	Sh3 type 3 domain protein
CS527_01005	COG0791	NLP P60 protein
CS527_01005	COG1388	LysM domain
CS527_01010	COG2213	PTS system mannitol-specific
CS527_01010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_01015	COG3711	transcriptional antiterminator
CS527_01020	COG0246	Mannitol dehydrogenase
CS527_01030	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_01035	COG1970	mechanosensitive ion channel activity
CS527_01040	COG1368	sulfuric ester hydrolase activity
CS527_01055	COG1176	ABC-type spermidine putrescine transport system, permease component I
CS527_01060	COG1177	transmembrane transport
CS527_01065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CS527_01075	COG0745	RESPONSE REGULATOR receiver
CS527_01080	COG5002	protein histidine kinase activity
CS527_01095	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CS527_01095	COG3976	FMN-binding domain protein
CS527_01100	COG1181	Belongs to the D-alanine--D-alanine ligase family
CS527_01105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS527_01110	COG0513	Belongs to the DEAD box helicase family
CS527_01115	COG4294	response to UV
CS527_01120	COG0705	Rhomboid family
CS527_01125	COG0736	holo-[acyl-carrier-protein] synthase activity
CS527_01130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CS527_01135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CS527_01140	COG0864	Transcriptional regulator
CS527_01145	COG2337	Toxic component of a toxin-antitoxin (TA) module
CS527_01150	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_01155	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_01160	COG2172	sigma factor antagonist activity
CS527_01165	COG2208	phosphoserine phosphatase activity
CS527_01170	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_01180	COG1191	sigma factor activity
CS527_01185	COG2208	phosphoserine phosphatase activity
CS527_01190	COG2183	response to ionizing radiation
CS527_01285	COG0802	atpase or kinase
CS527_01290	COG1214	PFAM Peptidase M22, glycoprotease
CS527_01295	COG0456	acetyltransferase
CS527_01305	COG0488	(ABC) transporter
CS527_01310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CS527_01315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_01320	COG0805	protein transport
CS527_01330	COG1266	CAAX protease self-immunity
CS527_01335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CS527_01345	COG0714	Associated with various cellular activities
CS527_01350	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CS527_01355	COG1305	Transglutaminase-like
CS527_01360	COG0519	Catalyzes the synthesis of GMP from XMP
CS527_01360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CS527_01365	COG2252	PERMEase
CS527_01420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CS527_01425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CS527_01430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CS527_01435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CS527_01440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CS527_01445	COG0047	phosphoribosylformylglycinamidine synthase activity
CS527_01450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CS527_01455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CS527_01460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CS527_01465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CS527_01470	COG0138	bifunctional purine biosynthesis protein purh
CS527_01475	COG0151	Belongs to the GarS family
CS527_01485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CS527_01490	COG4496	protein, YerC YecD
CS527_01495	COG0423	glycine-tRNA ligase activity
CS527_01505	COG0210	DNA helicase
CS527_01515	COG4851	CamS sex pheromone cAM373 precursor
CS527_01525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CS527_01530	COG0154	amidase activity
CS527_01540	COG1597	lipid kinase activity
CS527_01550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_01560	COG0166	Belongs to the GPI family
CS527_01565	COG1744	ABC transporter substrate-binding protein PnrA-like
CS527_01570	COG3852	Histidine kinase
CS527_01575	COG0024	Methionine aminopeptidase
CS527_01580	COG2706	6-phosphogluconolactonase activity
CS527_01590	COG4978	Transcriptional regulator
CS527_01590	COG0789	Transcriptional regulator
CS527_01595	COG2814	Major facilitator Superfamily
CS527_01605	COG1876	peptidase activity
CS527_01610	COG1126	abc transporter atp-binding protein
CS527_01615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_01620	COG0765	amino acid transport
CS527_01625	COG0765	amino acid transport
CS527_01630	COG1113	amino acid transport
CS527_01635	COG2733	membrane
CS527_01640	COG3212	peptidase
CS527_01645	COG3212	peptidase
CS527_01650	COG3850	Histidine kinase
CS527_01650	COG5002	protein histidine kinase activity
CS527_01655	COG0745	RESPONSE REGULATOR receiver
CS527_01660	COG2205	protein histidine kinase activity
CS527_01665	COG0745	RESPONSE REGULATOR receiver
CS527_01670	COG2311	Membrane
CS527_01685	COG0671	phosphoesterase, PA-phosphatase related
CS527_01690	COG1764	response to oxidative stress
CS527_01695	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CS527_01705	COG2259	Doxx family
CS527_01710	COG0693	protein deglycase activity
CS527_01720	COG2318	DinB family
CS527_01730	COG1115	amino acid carrier protein
CS527_01745	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CS527_01750	COG0598	Magnesium transport protein CorA
CS527_01755	COG3290	protein histidine kinase activity
CS527_01760	COG4565	transcriptional regulatory protein
CS527_01775	COG4191	Histidine kinase
CS527_01780	COG0513	Belongs to the DEAD box helicase family
CS527_01800	COG4842	Belongs to the WXG100 family
CS527_01805	COG5417	Belongs to the EsaB family
CS527_01810	COG4499	WXG100 protein secretion system (Wss), protein YukC
CS527_01815	COG1674	ftsk spoiiie
CS527_01815	COG0433	COG0433 Predicted ATPase
CS527_01820	COG1511	domain protein
CS527_01835	COG2356	endonuclease I
CS527_01845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_01860	COG0488	(ABC) transporter
CS527_01870	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CS527_01880	COG1959	2 iron, 2 sulfur cluster binding
CS527_01885	COG1017	nitric oxide dioxygenase activity
CS527_01885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS527_01895	COG0693	protein deglycase activity
CS527_01900	COG2340	Cysteine-rich secretory protein family
CS527_01905	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CS527_01910	COG4840	Belongs to the UPF0435 family
CS527_01915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CS527_01920	COG4980	gas vesicle protein
CS527_01925	COG1295	ribonuclease BN
CS527_01930	COG2217	Heavy metal translocating P-type atpase
CS527_01940	COG0640	Transcriptional regulator
CS527_01950	COG0477	Major facilitator Superfamily
CS527_01955	COG3479	Phenolic acid decarboxylase
CS527_01965	COG3871	stress protein (general stress protein 26)
CS527_01970	COG0387	Pfam Sodium calcium exchanger
CS527_01980	COG0535	radical SAM domain protein
CS527_02000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS527_02010	COG1113	amino acid transport
CS527_02015	COG5002	protein histidine kinase activity
CS527_02035	COG1090	epimerase
CS527_02045	COG4221	oxidoreductase activity
CS527_02065	COG1988	membrane-bound metal-dependent
CS527_02070	COG1194	a g-specific adenine glycosylase
CS527_02080	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_02095	COG3557	Belongs to the UPF0374 family
CS527_02100	COG1132	(ABC) transporter
CS527_02105	COG4129	membrane
CS527_02110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CS527_02115	COG4555	ABC transporter
CS527_02135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CS527_02140	COG0735	belongs to the Fur family
CS527_02250	COG4974	Belongs to the 'phage' integrase family
CS527_02340	COG3382	B3 4 domain protein
CS527_02355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CS527_02360	COG2766	serine protein kinase
CS527_02375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS527_02390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CS527_02400	COG1968	undecaprenyl-diphosphatase activity
CS527_02405	COG1301	dicarboxylic acid transport
CS527_02415	COG0586	Pfam SNARE associated Golgi protein
CS527_02420	COG2217	Heavy metal translocating P-type atpase
CS527_02425	COG0531	amino acid
CS527_02445	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CS527_02455	COG1175	transmembrane transport
CS527_02465	COG1653	transport
CS527_02470	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_02485	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_02530	COG3583	domain protein
CS527_02530	COG3584	3D domain protein
CS527_02535	COG1876	peptidase activity
CS527_02545	COG3103	Sh3 type 3 domain protein
CS527_02550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_02550	COG0456	acetyltransferase
CS527_02560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_02580	COG1609	Transcriptional regulator
CS527_02585	COG2814	Major facilitator Superfamily
CS527_02590	COG0673	inositol 2-dehydrogenase activity
CS527_02615	COG1609	Transcriptional regulator
CS527_02630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_02635	COG1522	sequence-specific DNA binding
CS527_02655	COG2814	Major facilitator Superfamily
CS527_02660	COG1309	transcriptional regulator
CS527_02665	COG1187	pseudouridine synthase activity
CS527_02675	COG1942	4-Oxalocrotonate Tautomerase
CS527_02680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS527_02685	COG0747	negative chemotaxis
CS527_02700	COG0084	hydrolase, TatD family'
CS527_02705	COG2962	Rard protein
CS527_02715	COG0628	permease
CS527_02730	COG0604	alcohol dehydrogenase
CS527_02735	COG1620	l-lactate permease
CS527_02745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS527_02750	COG0840	transmembrane signaling receptor activity
CS527_02755	COG0564	pseudouridine synthase activity
CS527_02765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS527_02770	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_02775	COG3153	acetyltransferase
CS527_02775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_02780	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CS527_02785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CS527_02795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CS527_02800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CS527_02805	COG1268	BioY protein
CS527_02815	COG2719	SpoVR family
CS527_02825	COG1959	2 iron, 2 sulfur cluster binding
CS527_02830	COG0604	alcohol dehydrogenase
CS527_02840	COG1126	abc transporter atp-binding protein
CS527_02845	COG0765	amino acid transport
CS527_02850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_02855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CS527_02860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CS527_02870	COG0352	thiamine-phosphate diphosphorylase activity
CS527_02875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_02890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS527_02895	COG0351	phosphomethylpyrimidine kinase
CS527_02910	COG0702	epimerase
CS527_02915	COG1253	flavin adenine dinucleotide binding
CS527_02930	COG3842	ATPase activity
CS527_02935	COG2508	Transcriptional regulator
CS527_02950	COG0189	ligase activity
CS527_02955	COG0189	ligase activity
CS527_02965	COG3679	Belongs to the UPF0342 family
CS527_02970	COG0561	phosphatase activity
CS527_02975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS527_02980	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_02985	COG1024	Enoyl-CoA hydratase
CS527_03000	COG4152	abc transporter atp-binding protein
CS527_03005	COG1668	transmembrane transport
CS527_03015	COG3481	metal-dependent phosphohydrolase, HD sub domain
CS527_03025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS527_03050	COG1846	Transcriptional regulator
CS527_03070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CS527_03075	COG1695	Transcriptional regulator
CS527_03080	COG2153	protein acetylation
CS527_03085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CS527_03085	COG2755	lipolytic protein G-D-S-L family
CS527_03090	COG0537	adenosine 5'-monophosphoramidase activity
CS527_03095	COG1131	(ABC) transporter
CS527_03100	COG4473	ABC transporter
CS527_03110	COG1473	amidohydrolase
CS527_03115	COG0671	phosphoesterase, PA-phosphatase related
CS527_03120	COG3069	C4-dicarboxylate transmembrane transporter activity
CS527_03125	COG2329	Antibiotic biosynthesis monooxygenase
CS527_03130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_03135	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CS527_03150	COG1309	transcriptional regulator
CS527_03165	COG2972	Histidine kinase
CS527_03180	COG1234	tRNA 3'-trailer cleavage
CS527_03185	COG0095	Lipoate-protein ligase
CS527_03190	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_03195	COG1024	Enoyl-CoA hydratase
CS527_03310	COG0501	Belongs to the peptidase M48B family
CS527_03315	COG2224	Isocitrate lyase
CS527_03325	COG1506	peptidase
CS527_03325	COG4946	Tricorn protease homolog
CS527_03325	COG0823	Involved in the tonB-independent uptake of proteins
CS527_03330	COG0398	Pfam SNARE associated Golgi protein
CS527_03335	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_03340	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CS527_03345	COG1074	ATP-dependent DNA helicase activity
CS527_03350	COG0420	3'-5' exonuclease activity
CS527_03355	COG0419	ATPase involved in DNA repair
CS527_03360	COG1403	HNH endonuclease
CS527_03395	COG2311	Membrane
CS527_03410	COG0367	asparagine synthase
CS527_03425	COG1562	ergosterol biosynthetic process
CS527_03430	COG0347	Belongs to the P(II) protein family
CS527_03435	COG0004	ammonium transporteR
CS527_03440	COG0366	Alpha amylase catalytic
CS527_03440	COG1874	Beta-galactosidase
CS527_03445	COG1609	Transcriptional regulator
CS527_03450	COG1012	belongs to the aldehyde dehydrogenase family
CS527_03455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CS527_03460	COG4187	Peptidase family M20/M25/M40
CS527_03465	COG0833	amino acid
CS527_03470	COG3829	transcription factor binding
CS527_03475	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_03480	COG1666	GTP binding
CS527_03485	COG2996	Protein conserved in bacteria
CS527_03495	COG1307	EDD domain protein, DegV family
CS527_03500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_03510	COG0561	phosphatase activity
CS527_03515	COG2151	metal-sulfur cluster biosynthetic enzyme
CS527_03520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS527_03525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CS527_03530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CS527_03535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CS527_03555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CS527_03570	COG0542	response to heat
CS527_03585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CS527_03590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CS527_03595	COG2084	Dehydrogenase
CS527_03605	COG2267	carboxylic ester hydrolase activity
CS527_03625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS527_03630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CS527_03635	COG5504	Zn-dependent protease
CS527_03640	COG0444	Belongs to the ABC transporter superfamily
CS527_03645	COG4608	Belongs to the ABC transporter superfamily
CS527_03655	COG0601	transmembrane transport
CS527_03670	COG0180	Tryptophanyl-tRNA synthetase
CS527_03680	COG4166	transmembrane transport
CS527_03685	COG0601	transmembrane transport
CS527_03690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_03695	COG0444	Belongs to the ABC transporter superfamily
CS527_03700	COG4608	Belongs to the ABC transporter superfamily
CS527_03705	COG0456	acetyltransferase
CS527_03710	COG1113	amino acid transport
CS527_03720	COG0531	amino acid
CS527_03725	COG1393	Belongs to the ArsC family
CS527_03730	COG0583	DNA-binding transcription factor activity
CS527_03745	COG0861	Integral membrane protein TerC family
CS527_03755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_03765	COG1164	Oligoendopeptidase f
CS527_03780	COG2346	COG2346, Truncated hemoglobins
CS527_03785	COG0741	lytic transglycosylase activity
CS527_03790	COG4116	CYTH
CS527_03800	COG2357	RelA SpoT domain protein
CS527_03805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS527_03810	COG0564	pseudouridine synthase activity
CS527_03820	COG2239	Acts as a magnesium transporter
CS527_03825	COG0475	glutathione-regulated potassium exporter activity
CS527_03825	COG0569	domain protein
CS527_03880	COG0210	DNA helicase
CS527_03890	COG2323	membrane
CS527_03895	COG2153	protein acetylation
CS527_03905	COG2382	esterase
CS527_03915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CS527_03925	COG1737	Transcriptional regulator
CS527_03930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CS527_03935	COG1070	Carbohydrate kinase
CS527_03940	COG1953	Uracil, thiamine, allantoin
CS527_03960	COG1522	sequence-specific DNA binding
CS527_03970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS527_03985	COG3142	Participates in the control of copper homeostasis
CS527_03990	COG1113	amino acid transport
CS527_04000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_04005	COG1309	transcriptional regulator
CS527_04010	COG3711	transcriptional antiterminator
CS527_04010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_04015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS527_04020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CS527_04025	COG1447	Phosphotransferase system cellobiose-specific component IIA
CS527_04030	COG1486	melibiose metabolic process
CS527_04035	COG3275	phosphorelay sensor kinase activity
CS527_04040	COG3279	Response regulator of the LytR AlgR family
CS527_04050	COG1346	cytolysis
CS527_04060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_04065	COG0243	molybdopterin cofactor binding
CS527_04070	COG2223	nitrite transmembrane transporter activity
CS527_04090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CS527_04115	COG3527	Alpha-acetolactate decarboxylase
CS527_04120	COG0028	Belongs to the TPP enzyme family
CS527_04130	COG4895	conserved protein (DUF2196)
CS527_04140	COG1733	regulation of RNA biosynthetic process
CS527_04145	COG2814	Major facilitator Superfamily
CS527_04150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_04175	COG3052	prosthetic group binding
CS527_04190	COG0784	Response regulator, receiver
CS527_04195	COG4191	Histidine kinase
CS527_04200	COG2066	Belongs to the glutaminase family
CS527_04205	COG1115	amino acid carrier protein
CS527_04210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_04220	COG4297	protein containing double-stranded beta helix domain
CS527_04225	COG0531	amino acid
CS527_04235	COG1607	acyl-coa hydrolase
CS527_04240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CS527_04255	COG0390	transport system, permease component
CS527_04260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CS527_04275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CS527_04280	COG1136	(ABC) transporter
CS527_04285	COG0577	efflux transmembrane transporter activity
CS527_04295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CS527_04300	COG1063	alcohol dehydrogenase
CS527_04315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS527_04320	COG0833	amino acid
CS527_04330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CS527_04335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_04345	COG0861	Integral membrane protein TerC family
CS527_04350	COG1301	dicarboxylic acid transport
CS527_04355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CS527_04360	COG3290	protein histidine kinase activity
CS527_04400	COG1476	TRANSCRIPTIONal
CS527_04410	COG1368	sulfuric ester hydrolase activity
CS527_04425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_04430	COG2040	homocysteine
CS527_04440	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS527_04460	COG3290	protein histidine kinase activity
CS527_04465	COG4565	transcriptional regulatory protein
CS527_04470	COG3181	Tripartite tricarboxylate transporter family receptor
CS527_04480	COG0583	DNA-binding transcription factor activity
CS527_04485	COG3180	Ammonia monooxygenase
CS527_04490	COG2226	methyltransferase
CS527_04500	COG4175	Glycine betaine
CS527_04500	COG0517	IMP dehydrogenase activity
CS527_04505	COG2113	Glycine betaine
CS527_04510	COG1309	transcriptional regulator
CS527_04530	COG0531	amino acid
CS527_04535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS527_04540	COG1464	Belongs to the NlpA lipoprotein family
CS527_04545	COG2011	ABC-type metal ion transport system permease component
CS527_04550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_04565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_04575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CS527_04580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_04585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_04610	COG1737	Transcriptional regulator
CS527_04615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_04615	COG1263	PTS System
CS527_04625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_04630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CS527_04635	COG1116	anion transmembrane transporter activity
CS527_04640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_04645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS527_04655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS527_04660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CS527_04665	COG1733	regulation of RNA biosynthetic process
CS527_04700	COG1511	domain protein
CS527_04710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CS527_04715	COG1733	regulation of RNA biosynthetic process
CS527_04725	COG1132	(ABC) transporter
CS527_04730	COG1132	(ABC) transporter
CS527_04740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_04745	COG3162	membrane
CS527_04755	COG1414	Transcriptional regulator
CS527_04760	COG0656	L-ascorbic acid biosynthetic process
CS527_04765	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CS527_04770	COG1846	Transcriptional regulator
CS527_04775	COG1566	PFAM secretion protein HlyD family protein
CS527_04780	COG2814	Major facilitator Superfamily
CS527_04785	COG0655	NAD(P)H dehydrogenase (quinone) activity
CS527_04800	COG1609	Transcriptional regulator
CS527_04805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_04815	COG1129	ABC transporter
CS527_04820	COG1172	Belongs to the binding-protein-dependent transport system permease family
CS527_04825	COG1879	ABC-type sugar transport system periplasmic component
CS527_04830	COG3583	domain protein
CS527_04830	COG3584	3D domain protein
CS527_04840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CS527_04845	COG1653	transport
CS527_04870	COG3706	GGDEF domain
CS527_04870	COG0745	RESPONSE REGULATOR receiver
CS527_04890	COG0745	RESPONSE REGULATOR receiver
CS527_04895	COG5002	protein histidine kinase activity
CS527_04935	COG0402	S-adenosylhomocysteine deaminase activity
CS527_04940	COG2252	PERMEase
CS527_04950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CS527_04955	COG1012	belongs to the aldehyde dehydrogenase family
CS527_04965	COG0710	3-dehydroquinate dehydratase activity
CS527_04975	COG1263	PTS System
CS527_04975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_04980	COG0366	Alpha amylase catalytic
CS527_04985	COG2188	Transcriptional regulator
CS527_04995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_05000	COG1984	allophanate hydrolase subunit 2
CS527_05005	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_05010	COG1914	H( )-stimulated, divalent metal cation uptake system
CS527_05015	COG1272	protein, Hemolysin III
CS527_05030	COG0778	Nitroreductase
CS527_05035	COG0628	permease
CS527_05060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CS527_05065	COG2271	Major facilitator Superfamily
CS527_05070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CS527_05075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS527_05080	COG1012	belongs to the aldehyde dehydrogenase family
CS527_05090	COG0402	S-adenosylhomocysteine deaminase activity
CS527_05095	COG1278	Cold shock
CS527_05100	COG2910	NAD(P)H-binding
CS527_05105	COG0673	inositol 2-dehydrogenase activity
CS527_05110	COG0450	alkyl hydroperoxide reductase
CS527_05115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_05145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_05150	COG2076	Multidrug Resistance protein
CS527_05155	COG2076	Multidrug Resistance protein
CS527_05225	COG1649	PFAM Uncharacterised BCR, COG1649
CS527_05230	COG1737	Transcriptional regulator
CS527_05250	COG1486	melibiose metabolic process
CS527_05260	COG1447	Phosphotransferase system cellobiose-specific component IIA
CS527_05270	COG2971	BadF BadG BcrA BcrD
CS527_05275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CS527_05280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_05290	COG3037	sugar-specific permease SgaT UlaA
CS527_05295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CS527_05295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_05305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CS527_05320	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_05325	COG4106	trans-aconitate 2-methyltransferase activity
CS527_05330	COG0583	DNA-binding transcription factor activity
CS527_05340	COG0667	Aldo Keto reductase
CS527_05365	COG1132	(ABC) transporter
CS527_05380	COG0154	amidase activity
CS527_05390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CS527_05430	COG2200	EAL domain
CS527_05430	COG2199	diguanylate cyclase activity
CS527_05440	COG1733	regulation of RNA biosynthetic process
CS527_05455	COG0385	Bile acid
CS527_05465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_05470	COG4191	Histidine kinase
CS527_05475	COG0784	Response regulator, receiver
CS527_05490	COG1388	LysM domain
CS527_05490	COG0791	NLP P60 protein
CS527_05500	COG2385	sporulation resulting in formation of a cellular spore
CS527_05505	COG0656	L-ascorbic acid biosynthetic process
CS527_05520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS527_05525	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_05560	COG0477	Major facilitator Superfamily
CS527_05565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS527_05575	COG0640	Transcriptional regulator
CS527_05580	COG5658	integral membrane protein
CS527_05600	COG5001	Diguanylate cyclase
CS527_05600	COG3300	MHYT domain
CS527_05605	COG0302	gtp cyclohydrolase
CS527_05625	COG2843	Capsule synthesis protein
CS527_05640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CS527_05675	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS527_05705	COG4464	protein tyrosine phosphatase activity
CS527_05710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CS527_05715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_05730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CS527_05735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CS527_05740	COG0438	transferase activity, transferring glycosyl groups
CS527_05765	COG2244	polysaccharide biosynthetic process
CS527_05770	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CS527_05780	COG3944	biosynthesis protein
CS527_05785	COG0489	protein tyrosine kinase activity
CS527_05790	COG1316	TRANSCRIPTIONal
CS527_05810	COG0028	Belongs to the TPP enzyme family
CS527_05815	COG0069	glutamate synthase activity
CS527_05860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_05865	COG2146	nitrite reductase [NAD(P)H] activity
CS527_05875	COG2116	formate transmembrane transporter activity
CS527_05885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_05890	COG4975	Glucose uptake
CS527_05905	COG0534	Mate efflux family protein
CS527_05915	COG1316	TRANSCRIPTIONal
CS527_05925	COG0598	Magnesium transport protein CorA
CS527_05930	COG1404	Belongs to the peptidase S8 family
CS527_05955	COG4821	SIS domain
CS527_05965	COG0363	glucosamine-6-phosphate deaminase activity
CS527_05970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CS527_05975	COG2190	(PTS) system
CS527_05975	COG1263	PTS System
CS527_05975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_05980	COG1811	Na channel or pump
CS527_05985	COG3961	Belongs to the TPP enzyme family
CS527_06020	COG1131	(ABC) transporter
CS527_06025	COG1253	flavin adenine dinucleotide binding
CS527_06030	COG0789	Transcriptional regulator
CS527_06040	COG0346	lactoylglutathione lyase activity
CS527_06045	COG2105	PFAM AIG2 family protein
CS527_06045	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CS527_06105	COG4187	Peptidase family M20/M25/M40
CS527_06120	COG0456	acetyltransferase
CS527_06120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CS527_06140	COG2252	PERMEase
CS527_06150	COG3279	Response regulator of the LytR AlgR family
CS527_06155	COG4555	ABC transporter
CS527_06160	COG1668	transmembrane transport
CS527_06170	COG0789	Transcriptional regulator
CS527_06175	COG1846	Transcriptional regulator
CS527_06180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_06180	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_06200	COG1785	Belongs to the alkaline phosphatase family
CS527_06205	COG3279	Response regulator of the LytR AlgR family
CS527_06210	COG0784	Response regulator, receiver
CS527_06210	COG2205	protein histidine kinase activity
CS527_06215	COG0861	Integral membrane protein TerC family
CS527_06220	COG1191	sigma factor activity
CS527_06250	COG3243	poly(R)-hydroxyalkanoic acid synthase
CS527_06255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS527_06270	COG2186	Transcriptional regulator
CS527_06275	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CS527_06285	COG0247	lactate metabolic process
CS527_06290	COG1139	Iron-sulfur cluster binding protein
CS527_06295	COG1556	Lactate utilization protein
CS527_06300	COG5002	protein histidine kinase activity
CS527_06305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CS527_06310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CS527_06315	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CS527_06320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_06325	COG0436	Aminotransferase
CS527_06330	COG1850	ribulose-bisphosphate carboxylase activity
CS527_06335	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CS527_06340	COG0235	Class ii aldolase
CS527_06345	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CS527_06355	COG1129	ABC transporter
CS527_06360	COG1172	Belongs to the binding-protein-dependent transport system permease family
CS527_06390	COG1846	Transcriptional regulator
CS527_06400	COG4191	Histidine kinase
CS527_06410	COG0542	response to heat
CS527_06425	COG0300	oxidoreductase activity
CS527_06430	COG0697	spore germination
CS527_06450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CS527_06455	COG0720	synthase
CS527_06465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CS527_06470	COG0702	epimerase
CS527_06480	COG4873	Protein conserved in bacteria
CS527_06500	COG3773	Cell wall hydrolase
CS527_06540	COG1410	methionine synthase
CS527_06540	COG0646	methionine synthase
CS527_06545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CS527_06545	COG0646	methionine synthase
CS527_06550	COG3949	Membrane
CS527_06560	COG0307	riboflavin synthase, alpha
CS527_06570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CS527_06580	COG3711	transcriptional antiterminator
CS527_06585	COG2190	(PTS) system
CS527_06585	COG1263	PTS System
CS527_06585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_06600	COG1346	cytolysis
CS527_06610	COG0583	DNA-binding transcription factor activity
CS527_06620	COG0456	acetyltransferase
CS527_06625	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_06630	COG0778	Nitroreductase
CS527_06635	COG0436	Aminotransferase
CS527_06655	COG0835	chemotaxis
CS527_06655	COG0784	Response regulator, receiver
CS527_06665	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_06685	COG1408	metallophosphoesterase
CS527_06690	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_06695	COG2200	EAL domain
CS527_06710	COG4703	Protein of unknown function (DUF1797)
CS527_06715	COG0517	IMP dehydrogenase activity
CS527_06720	COG0583	DNA-binding transcription factor activity
CS527_06725	COG2171	N-acyltransferase activity
CS527_06730	COG1473	amidohydrolase
CS527_06740	COG0668	transmembrane transport
CS527_06745	COG0450	alkyl hydroperoxide reductase
CS527_06750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_06755	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CS527_06760	COG1132	(ABC) transporter
CS527_06765	COG1132	(ABC) transporter
CS527_06770	COG0569	domain protein
CS527_06775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS527_06785	COG0561	phosphatase activity
CS527_06810	COG0022	dehydrogenase e1 component
CS527_06815	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_06840	COG1982	Orn Lys Arg decarboxylase major
CS527_06845	COG4476	Belongs to the UPF0223 family
CS527_06850	COG4493	Belongs to the UPF0637 family
CS527_06860	COG0483	inositol monophosphate 1-phosphatase activity
CS527_06885	COG4896	Protein conserved in bacteria
CS527_06900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CS527_06905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CS527_06910	COG4838	Belongs to the UPF0358 family
CS527_06915	COG0772	Belongs to the SEDS family
CS527_06920	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CS527_06925	COG1612	heme a metabolic process
CS527_06930	COG0109	protoheme IX farnesyltransferase activity
CS527_06955	COG3336	cytochrome c oxidase
CS527_06965	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CS527_06970	COG2340	Cysteine-rich secretory protein family
CS527_06980	COG2738	Putative neutral zinc metallopeptidase
CS527_06985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_06990	COG1694	Mazg nucleotide pyrophosphohydrolase
CS527_06995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CS527_07000	COG1803	Methylglyoxal synthase
CS527_07005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS527_07010	COG0438	transferase activity, transferring glycosyl groups
CS527_07015	COG0617	tRNA 3'-terminal CCA addition
CS527_07020	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CS527_07020	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CS527_07030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CS527_07035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CS527_07040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CS527_07040	COG1199	ATP-dependent helicase activity
CS527_07060	COG0436	Aminotransferase
CS527_07065	COG0017	Asparaginyl-tRNA synthetase
CS527_07070	COG3935	DnaD domain protein
CS527_07075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CS527_07085	COG4499	WXG100 protein secretion system (Wss), protein YukC
CS527_07085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_07090	COG3331	DNA recombination
CS527_07125	COG5337	Spore coat protein CotH
CS527_07140	COG0626	cystathionine gamma-synthase activity
CS527_07145	COG0626	cystathionine gamma-synthase activity
CS527_07160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_07170	COG1278	Cold shock
CS527_07240	COG2197	response regulator
CS527_07245	COG0366	Alpha amylase catalytic
CS527_07250	COG0116	Belongs to the methyltransferase superfamily
CS527_07265	COG1175	transmembrane transport
CS527_07275	COG3842	ATPase activity
CS527_07285	COG1199	ATP-dependent helicase activity
CS527_07290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CS527_07295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS527_07300	COG2233	PERMEase
CS527_07305	COG0583	DNA-binding transcription factor activity
CS527_07310	COG1012	belongs to the aldehyde dehydrogenase family
CS527_07320	COG3424	synthase
CS527_07325	COG1755	Isoprenylcysteine carboxyl methyltransferase
CS527_07330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CS527_07335	COG3541	Predicted nucleotidyltransferase
CS527_07360	COG0328	RNA-DNA hybrid ribonuclease activity
CS527_07365	COG0328	RNA-DNA hybrid ribonuclease activity
CS527_07390	COG2814	Major facilitator Superfamily
CS527_07400	COG2233	PERMEase
CS527_07405	COG2362	D-Aminopeptidase
CS527_07410	COG0601	transmembrane transport
CS527_07415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_07420	COG0444	Belongs to the ABC transporter superfamily
CS527_07425	COG4166	transmembrane transport
CS527_07430	COG1619	proteins homologs of microcin C7 resistance protein MccF
CS527_07435	COG0791	NLP P60 protein
CS527_07440	COG4608	Belongs to the ABC transporter superfamily
CS527_07460	COG5001	Diguanylate cyclase
CS527_07460	COG3300	MHYT domain
CS527_07490	COG2197	response regulator
CS527_07495	COG4585	Histidine kinase
CS527_07500	COG3239	Fatty acid desaturase
CS527_07505	COG2205	protein histidine kinase activity
CS527_07515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_07530	COG0791	NLP P60 protein
CS527_07530	COG1388	LysM domain
CS527_07535	COG1819	glycosyl
CS527_07540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_07555	COG2814	Major facilitator Superfamily
CS527_07565	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_07570	COG3964	amidohydrolase
CS527_07590	COG2188	Transcriptional regulator
CS527_07600	COG0434	BtpA family
CS527_07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS527_07615	COG1785	Belongs to the alkaline phosphatase family
CS527_07620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS527_07625	COG1404	Belongs to the peptidase S8 family
CS527_07635	COG1846	Transcriptional regulator
CS527_07640	COG1566	PFAM secretion protein HlyD family protein
CS527_07645	COG2814	Major facilitator Superfamily
CS527_07650	COG1846	Transcriptional regulator
CS527_07670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_07675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_07680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_07685	COG1120	ATPase activity
CS527_07700	COG2814	Major facilitator Superfamily
CS527_07720	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_07725	COG1733	regulation of RNA biosynthetic process
CS527_07740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_07750	COG3448	diguanylate cyclase activity
CS527_07750	COG4175	Glycine betaine
CS527_07770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CS527_07775	COG2208	phosphoserine phosphatase activity
CS527_07785	COG0531	amino acid
CS527_07795	COG1011	Hydrolase
CS527_07800	COG0405	Gamma-glutamyltransferase
CS527_07805	COG1621	beta-fructofuranosidase activity
CS527_07810	COG1621	beta-fructofuranosidase activity
CS527_07815	COG2193	ferroxidase activity
CS527_07820	COG0477	Major facilitator Superfamily
CS527_07830	COG0156	8-amino-7-oxononanoate synthase activity
CS527_07835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CS527_07845	COG2814	Major facilitator Superfamily
CS527_07860	COG1012	belongs to the aldehyde dehydrogenase family
CS527_07865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_07875	COG1280	lysine exporter protein (LysE YggA)
CS527_07880	COG1113	amino acid transport
CS527_07890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS527_07915	COG1113	amino acid transport
CS527_07935	COG1609	Transcriptional regulator
CS527_07940	COG2223	nitrite transmembrane transporter activity
CS527_07950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CS527_07955	COG1621	beta-fructofuranosidase activity
CS527_07960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CS527_07960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CS527_07965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_07970	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_07975	COG3715	PTS system
CS527_07980	COG3716	PTS system mannose fructose sorbose family IID component
CS527_07985	COG1621	beta-fructofuranosidase activity
CS527_07990	COG0765	amino acid transport
CS527_07995	COG0765	amino acid transport
CS527_08000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_08005	COG1464	Belongs to the NlpA lipoprotein family
CS527_08010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_08015	COG2011	ABC-type metal ion transport system permease component
CS527_08035	COG1464	Belongs to the NlpA lipoprotein family
CS527_08040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_08045	COG2011	ABC-type metal ion transport system permease component
CS527_08050	COG1464	Belongs to the NlpA lipoprotein family
CS527_08060	COG0024	Methionine aminopeptidase
CS527_08080	COG0596	Alpha beta hydrolase
CS527_08085	COG0697	spore germination
CS527_08100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_08105	COG0531	amino acid
CS527_08115	COG2723	6-phospho-beta-galactosidase activity
CS527_08120	COG2188	Transcriptional regulator
CS527_08130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS527_08140	COG0656	L-ascorbic acid biosynthetic process
CS527_08145	COG2986	histidine ammonia-lyase
CS527_08150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CS527_08155	COG1228	amidohydrolase
CS527_08160	COG0010	Belongs to the arginase family
CS527_08165	COG1846	Transcriptional regulator
CS527_08170	COG1957	nucleoside hydrolase
CS527_08180	COG1288	antiporter activity
CS527_08185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CS527_08215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_08235	COG2364	Membrane
CS527_08240	COG1846	Transcriptional regulator
CS527_08245	COG0456	acetyltransferase
CS527_08280	COG3848	Pyruvate phosphate dikinase
CS527_08280	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_08285	COG1309	transcriptional regulator
CS527_08290	COG2814	Major facilitator Superfamily
CS527_08295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CS527_08300	COG3958	Transketolase
CS527_08305	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_08310	COG2186	Transcriptional regulator
CS527_08325	COG0698	ribose 5-phosphate isomerase
CS527_08350	COG1388	LysM domain
CS527_08350	COG0791	NLP P60 protein
CS527_08355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CS527_08370	COG2318	DinB family
CS527_08395	COG0583	DNA-binding transcription factor activity
CS527_08400	COG0596	Alpha beta hydrolase
CS527_08430	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_08450	COG0726	polysaccharide deacetylase
CS527_08460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_08470	COG0697	spore germination
CS527_08475	COG4977	sequence-specific DNA binding
CS527_08500	COG0387	Pfam Sodium calcium exchanger
CS527_08505	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_08520	COG1309	transcriptional regulator
CS527_08525	COG0861	Integral membrane protein TerC family
CS527_08535	COG5577	PFAM Coat F domain
CS527_08550	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_08560	COG1522	sequence-specific DNA binding
CS527_08565	COG3813	Protein conserved in bacteria
CS527_08595	COG2076	Multidrug Resistance protein
CS527_08615	COG1278	Cold shock
CS527_08625	COG0513	Belongs to the DEAD box helicase family
CS527_08630	COG1278	Cold shock
CS527_08680	COG0747	negative chemotaxis
CS527_08685	COG0601	transmembrane transport
CS527_08695	COG0444	Belongs to the ABC transporter superfamily
CS527_08700	COG4608	Belongs to the ABC transporter superfamily
CS527_08705	COG0534	Mate efflux family protein
CS527_08725	COG2172	sigma factor antagonist activity
CS527_08735	COG0477	Major facilitator Superfamily
CS527_08740	COG3858	chitin binding
CS527_08740	COG1388	LysM domain
CS527_08745	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_08775	COG2226	methyltransferase
CS527_08790	COG1733	regulation of RNA biosynthetic process
CS527_08795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_08810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_08815	COG3420	alginic acid biosynthetic process
CS527_08835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS527_08840	COG0640	Transcriptional regulator
CS527_08850	COG0640	Transcriptional regulator
CS527_08855	COG0346	lactoylglutathione lyase activity
CS527_08860	COG0475	glutathione-regulated potassium exporter activity
CS527_08860	COG0589	response to stress
CS527_08870	COG3011	Protein conserved in bacteria
CS527_08905	COG0583	DNA-binding transcription factor activity
CS527_08910	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CS527_08925	COG0753	catalase activity
CS527_08940	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_08945	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_08965	COG0384	phenazine biosynthesis protein PhzF
CS527_08975	COG5577	PFAM Coat F domain
CS527_08985	COG1063	alcohol dehydrogenase
CS527_08990	COG5577	PFAM Coat F domain
CS527_09005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CS527_09010	COG2205	protein histidine kinase activity
CS527_09010	COG0784	Response regulator, receiver
CS527_09030	COG0673	inositol 2-dehydrogenase activity
CS527_09035	COG0673	inositol 2-dehydrogenase activity
CS527_09040	COG1082	Xylose isomerase domain protein TIM barrel
CS527_09045	COG2814	Major facilitator Superfamily
CS527_09055	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_09070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_09085	COG0384	phenazine biosynthesis protein PhzF
CS527_09090	COG1694	Mazg nucleotide pyrophosphohydrolase
CS527_09110	COG0789	Transcriptional regulator
CS527_09115	COG1278	Cold shock
CS527_09175	COG1113	amino acid transport
CS527_09185	COG2207	Transcriptional regulator
CS527_09195	COG2376	Dihydroxyacetone kinase
CS527_09250	COG2323	membrane
CS527_09255	COG2323	membrane
CS527_09270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS527_09350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_09355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_09375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_09380	COG1587	Uroporphyrinogen-III synthase
CS527_09385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_09390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CS527_09405	COG1982	Orn Lys Arg decarboxylase major
CS527_09420	COG1073	alpha beta
CS527_09435	COG3545	Serine hydrolase
CS527_09440	COG3223	Belongs to the PsiE family
CS527_09445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS527_09455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_09470	COG1278	Cold shock
CS527_09480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_09485	COG0697	spore germination
CS527_09500	COG2226	methyltransferase
CS527_09505	COG0138	bifunctional purine biosynthesis protein purh
CS527_09510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_09515	COG1114	Component of the transport system for branched-chain amino acids
CS527_09525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CS527_09555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CS527_09555	COG1017	nitric oxide dioxygenase activity
CS527_09565	COG3848	Pyruvate phosphate dikinase
CS527_09565	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_09570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CS527_09580	COG0477	Major facilitator Superfamily
CS527_09600	COG1012	belongs to the aldehyde dehydrogenase family
CS527_09635	COG0517	IMP dehydrogenase activity
CS527_09650	COG1309	transcriptional regulator
CS527_09665	COG1070	Carbohydrate kinase
CS527_09670	COG0477	Major facilitator Superfamily
CS527_09670	COG2814	Major facilitator Superfamily
CS527_09680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CS527_09685	COG1845	cytochrome c oxidase, subunit III
CS527_09695	COG0589	response to stress
CS527_09705	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_09710	COG1612	heme a metabolic process
CS527_09715	COG2072	flavoprotein involved in K transport
CS527_09725	COG2252	PERMEase
CS527_09730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS527_09735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CS527_09740	COG0022	dehydrogenase e1 component
CS527_09745	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_09750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS527_09755	COG3284	Transcriptional regulator
CS527_09760	COG1063	alcohol dehydrogenase
CS527_09770	COG1846	Transcriptional regulator
CS527_09780	COG2721	sulfolactate sulfo-lyase activity
CS527_09790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS527_09795	COG1012	belongs to the aldehyde dehydrogenase family
CS527_09800	COG2271	Major facilitator Superfamily
CS527_09805	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_09810	COG2186	Transcriptional regulator
CS527_09830	COG0628	permease
CS527_09835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_09845	COG2211	Major facilitator Superfamily
CS527_09870	COG0589	response to stress
CS527_09875	COG5002	protein histidine kinase activity
CS527_09885	COG1937	Protein conserved in bacteria
CS527_09890	COG2608	mercury ion transmembrane transporter activity
CS527_09895	COG2217	Heavy metal translocating P-type atpase
CS527_09905	COG1388	LysM domain
CS527_09910	COG2271	Major facilitator Superfamily
CS527_09940	COG0640	Transcriptional regulator
CS527_09945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CS527_09955	COG2050	protein possibly involved in aromatic compounds catabolism
CS527_09960	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CS527_09965	COG2323	membrane
CS527_09980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_09985	COG1802	Transcriptional regulator
CS527_09990	COG0473	3-isopropylmalate dehydrogenase activity
CS527_09995	COG2814	Major facilitator Superfamily
CS527_10000	COG1733	regulation of RNA biosynthetic process
CS527_10005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS527_10005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CS527_10010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS527_10010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CS527_10025	COG2226	methyltransferase
CS527_10035	COG5566	PFAM Mor transcription activator
CS527_10050	COG0561	phosphatase activity
CS527_10055	COG1876	peptidase activity
CS527_10060	COG0726	polysaccharide deacetylase
CS527_10100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CS527_10115	COG0386	Belongs to the glutathione peroxidase family
CS527_10120	COG1418	mRNA catabolic process
CS527_10125	COG0488	(ABC) transporter
CS527_10130	COG1413	lyase activity
CS527_10135	COG0726	polysaccharide deacetylase
CS527_10145	COG2521	methyltransferase
CS527_10145	COG2136	Putative SAM-dependent methyltransferase
CS527_10155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_10160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_10170	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CS527_10175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CS527_10180	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CS527_10185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CS527_10190	COG0406	alpha-ribazole phosphatase activity
CS527_10200	COG2096	Adenosyltransferase
CS527_10205	COG2962	Rard protein
CS527_10215	COG0523	cobalamin synthesis protein
CS527_10220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS527_10225	COG0322	excinuclease ABC activity
CS527_10235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS527_10240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS527_10245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CS527_10255	COG3011	Protein conserved in bacteria
CS527_10260	COG1595	DNA-templated transcription, initiation
CS527_10280	COG2002	toxin-antitoxin pair type II binding
CS527_10285	COG0534	Mate efflux family protein
CS527_10290	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_10315	COG1368	sulfuric ester hydrolase activity
CS527_10325	COG3853	Toxic anion resistance protein (TelA)
CS527_10340	COG0726	polysaccharide deacetylase
CS527_10350	COG2234	aminopeptidase activity
CS527_10355	COG5002	protein histidine kinase activity
CS527_10365	COG1823	symporter activity
CS527_10370	COG1523	belongs to the glycosyl hydrolase 13 family
CS527_10375	COG1012	belongs to the aldehyde dehydrogenase family
CS527_10380	COG2124	cytochrome p450
CS527_10385	COG2112	serine threonine protein kinase
CS527_10395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CS527_10400	COG1360	Flagellar Motor Protein
CS527_10415	COG3361	conserved protein (COG2071)
CS527_10420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CS527_10425	COG1757	Na H antiporter
CS527_10435	COG0833	amino acid
CS527_10440	COG3594	Acyltransferase
CS527_10445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CS527_10450	COG0745	RESPONSE REGULATOR receiver
CS527_10455	COG5002	protein histidine kinase activity
CS527_10460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS527_10465	COG3104	oligopeptide transport
CS527_10475	COG0281	malic enzyme
CS527_10480	COG3493	citrate carrier protein
CS527_10485	COG0561	phosphatase activity
CS527_10495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_10510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CS527_10515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_10520	COG0765	amino acid transport
CS527_10525	COG0765	amino acid transport
CS527_10530	COG1126	abc transporter atp-binding protein
CS527_10535	COG0196	riboflavin kinase activity
CS527_10540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_10550	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_10590	COG1611	Belongs to the LOG family
CS527_10595	COG0281	malic enzyme
CS527_10600	COG3402	PFAM membrane-flanked domain
CS527_10605	COG3428	Bacterial PH domain
CS527_10620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_10625	COG0109	protoheme IX farnesyltransferase activity
CS527_10630	COG4195	phage-related replication protein
CS527_10640	COG0789	Transcriptional regulator
CS527_10675	COG0583	DNA-binding transcription factor activity
CS527_10680	COG0070	glutamate synthase
CS527_10680	COG0067	glutamate synthase
CS527_10680	COG0069	glutamate synthase activity
CS527_10685	COG0493	'glutamate synthase
CS527_10705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CS527_10720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_10735	COG1846	Transcriptional regulator
CS527_10740	COG1380	Effector of murein hydrolase LrgA
CS527_10745	COG1346	cytolysis
CS527_10750	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_10765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CS527_10770	COG0463	Glycosyl transferase, family 2
CS527_10780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_10785	COG0745	RESPONSE REGULATOR receiver
CS527_10795	COG5583	Uncharacterized small protein (DUF2292)
CS527_10805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CS527_10815	COG4208	sulfate ABC transporter
CS527_10830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_10840	COG1349	DNA-binding transcription factor activity
CS527_10845	COG1105	Belongs to the carbohydrate kinase PfkB family
CS527_10850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS527_10850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CS527_10850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_10855	COG0527	aspartate kinase activity
CS527_10865	COG2032	superoxide dismutase activity
CS527_10870	COG1233	COG1233 Phytoene dehydrogenase and related
CS527_10880	COG0300	oxidoreductase activity
CS527_10885	COG0640	Transcriptional regulator
CS527_10890	COG1012	belongs to the aldehyde dehydrogenase family
CS527_10895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CS527_10910	COG0733	neurotransmitter:sodium symporter activity
CS527_10920	COG3773	Cell wall hydrolase
CS527_10940	COG0673	inositol 2-dehydrogenase activity
CS527_10945	COG1082	Xylose isomerase domain protein TIM barrel
CS527_10950	COG2094	Belongs to the DNA glycosylase MPG family
CS527_10960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CS527_10970	COG0454	-acetyltransferase
CS527_10980	COG2814	Major facilitator Superfamily
CS527_10995	COG3871	stress protein (general stress protein 26)
CS527_11020	COG1595	DNA-templated transcription, initiation
CS527_11030	COG0714	Associated with various cellular activities
CS527_11035	COG4548	von Willebrand factor, type A
CS527_11040	COG0697	spore germination
CS527_11050	COG2207	Transcriptional regulator
CS527_11055	COG1994	Peptidase M50
CS527_11060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_11065	COG1119	ATPase activity
CS527_11080	COG1657	PFAM Prenyltransferase squalene oxidase
CS527_11090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CS527_11090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CS527_11100	COG0384	phenazine biosynthesis protein PhzF
CS527_11115	COG1378	Sugar-specific transcriptional regulator TrmB
CS527_11120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_11125	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_11145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_11150	COG1279	arginine transmembrane transporter activity
CS527_11180	COG1396	sequence-specific DNA binding
CS527_11195	COG0494	nUDIX hydrolase
CS527_11200	COG1335	isochorismatase
CS527_11205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CS527_11210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CS527_11220	COG1098	S1 RNA binding domain
CS527_11225	COG1404	Belongs to the peptidase S8 family
CS527_11230	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_11235	COG1254	Belongs to the acylphosphatase family
CS527_11240	COG2223	nitrite transmembrane transporter activity
CS527_11245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_11255	COG0662	Cupin 2, conserved barrel domain protein
CS527_11255	COG2207	Transcriptional regulator
CS527_11260	COG0697	spore germination
CS527_11265	COG0488	(ABC) transporter
CS527_11275	COG0697	spore germination
CS527_11280	COG0531	amino acid
CS527_11295	COG1131	(ABC) transporter
CS527_11300	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS527_11305	COG1757	Na H antiporter
CS527_11310	COG1609	Transcriptional regulator
CS527_11320	COG1533	DNA photolyase activity
CS527_11340	COG0551	DNA topoisomerase type I activity
CS527_11340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS527_11350	COG0446	pyridine nucleotide-disulphide oxidoreductase
CS527_11380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_11400	COG1757	Na H antiporter
CS527_11405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CS527_11415	COG0697	spore germination
CS527_11425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_11435	COG2720	vancomycin resistance protein
CS527_11475	COG0514	ATP-dependent DNA helicase (RecQ)
CS527_11505	COG1575	Belongs to the MenA family. Type 1 subfamily
CS527_11510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CS527_11530	COG0583	DNA-binding transcription factor activity
CS527_11535	COG1725	Transcriptional regulator
CS527_11540	COG1131	(ABC) transporter
CS527_11550	COG1595	DNA-templated transcription, initiation
CS527_11565	COG1764	response to oxidative stress
CS527_11570	COG1846	Transcriptional regulator
CS527_11585	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
CS527_11595	COG3584	3D domain protein
CS527_11595	COG1388	LysM domain
CS527_11615	COG5002	protein histidine kinase activity
CS527_11620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS527_11625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CS527_11630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CS527_11645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CS527_11660	COG2409	Drug exporters of the RND superfamily
CS527_11665	COG1834	amidinotransferase
CS527_11675	COG1295	ribonuclease BN
CS527_11760	COG0110	maltose O-acetyltransferase activity
CS527_11765	COG0346	lactoylglutathione lyase activity
CS527_11775	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_11785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CS527_11795	COG2176	DNA-directed DNA polymerase activity
CS527_11810	COG0114	fumarate hydratase activity
CS527_11820	COG3757	hydrolase, family 25
CS527_11820	COG3409	Peptidoglycan-binding domain 1 protein
CS527_11830	COG5002	protein histidine kinase activity
CS527_11870	COG0778	Nitroreductase
CS527_11880	COG0300	oxidoreductase activity
CS527_11885	COG3290	protein histidine kinase activity
CS527_11890	COG4565	transcriptional regulatory protein
CS527_11895	COG2851	Citrate transporter
CS527_11905	COG2610	gluconate transmembrane transporter activity
CS527_11910	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_11915	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS527_11945	COG0583	DNA-binding transcription factor activity
CS527_11960	COG1301	dicarboxylic acid transport
CS527_11965	COG0019	diaminopimelate decarboxylase activity
CS527_11985	COG4191	Histidine kinase
CS527_12005	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_12015	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS527_12020	COG1024	Enoyl-CoA hydratase
CS527_12035	COG2045	Belongs to the ComB family
CS527_12040	COG1960	acyl-CoA dehydrogenase activity
CS527_12045	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_12050	COG1024	Enoyl-CoA hydratase
CS527_12065	COG1141	Ferredoxin
CS527_12075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS527_12085	COG0183	Belongs to the thiolase family
CS527_12090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_12115	COG1509	lysine 2,3-aminomutase activity
CS527_12125	COG0833	amino acid
CS527_12130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_12145	COG1979	alcohol dehydrogenase
CS527_12150	COG0738	Major facilitator superfamily
CS527_12155	COG1181	Belongs to the D-alanine--D-alanine ligase family
CS527_12175	COG3977	Valine--pyruvate aminotransferase
CS527_12180	COG3773	Cell wall hydrolase
CS527_12205	COG0531	amino acid
CS527_12210	COG2814	Major facilitator Superfamily
CS527_12215	COG1846	Transcriptional regulator
CS527_12220	COG2409	Drug exporters of the RND superfamily
CS527_12220	COG1033	growth of symbiont in host cell
CS527_12225	COG3842	ATPase activity
CS527_12230	COG2222	sugar isomerase
CS527_12235	COG1653	transport
CS527_12240	COG1175	transmembrane transport
CS527_12245	COG0395	ABC-type sugar transport system, permease component
CS527_12250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_12255	COG2188	Transcriptional regulator
CS527_12260	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_12260	COG2202	Pas domain
CS527_12265	COG3832	glyoxalase III activity
CS527_12270	COG0640	Transcriptional regulator
CS527_12280	COG2267	carboxylic ester hydrolase activity
CS527_12290	COG3386	PFAM SMP-30 Gluconolaconase
CS527_12300	COG2368	4-hydroxyphenylacetate
CS527_12305	COG3739	integral membrane protein
CS527_12315	COG0326	Molecular chaperone. Has ATPase activity
CS527_12320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS527_12340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS527_12345	COG3757	hydrolase, family 25
CS527_12345	COG3409	Peptidoglycan-binding domain 1 protein
CS527_12355	COG0697	spore germination
CS527_12360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_12375	COG4572	Cation transport regulator
CS527_12380	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CS527_12385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS527_12400	COG3011	Protein conserved in bacteria
CS527_12405	COG1136	(ABC) transporter
CS527_12465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_12480	COG0494	nUDIX hydrolase
CS527_12485	COG0702	epimerase
CS527_12490	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_12495	COG1846	Transcriptional regulator
CS527_12500	COG2720	vancomycin resistance protein
CS527_12505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS527_12530	COG0076	glutamate decarboxylase activity
CS527_12560	COG2116	formate transmembrane transporter activity
CS527_12565	COG5609	conserved protein (DUF2294)
CS527_12580	COG2271	Major facilitator Superfamily
CS527_12585	COG0277	FAD linked oxidase domain protein
CS527_12590	COG0840	transmembrane signaling receptor activity
CS527_12600	COG0622	Phosphoesterase
CS527_12610	COG1408	metallophosphoesterase
CS527_12615	COG3663	DNA glycosylase
CS527_12620	COG0791	NLP P60 protein
CS527_12620	COG3883	PFAM NLP P60 protein
CS527_12625	COG1587	Uroporphyrinogen-III synthase
CS527_12630	COG1414	Transcriptional regulator
CS527_12635	COG0439	Biotin carboxylase
CS527_12640	COG0511	ligase activity, forming carbon-carbon bonds
CS527_12645	COG1984	allophanate hydrolase subunit 2
CS527_12650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_12655	COG4336	lyase activity
CS527_12660	COG1914	H( )-stimulated, divalent metal cation uptake system
CS527_12665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CS527_12680	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_12685	COG1268	BioY protein
CS527_12690	COG0183	Belongs to the thiolase family
CS527_12710	COG0431	NADPH-dependent FMN reductase
CS527_12715	COG2197	response regulator
CS527_12720	COG2203	Gaf domain
CS527_12720	COG4585	Histidine kinase
CS527_12740	COG0697	spore germination
CS527_12750	COG2153	protein acetylation
CS527_12755	COG0129	dihydroxy-acid dehydratase activity
CS527_12760	COG2267	carboxylic ester hydrolase activity
CS527_12765	COG1227	inorganic diphosphatase activity
CS527_12785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CS527_12795	COG0204	Acyl-transferase
CS527_12800	COG2233	PERMEase
CS527_12805	COG3648	Uricase
CS527_12805	COG3195	allantoin biosynthetic process
CS527_12830	COG1914	H( )-stimulated, divalent metal cation uptake system
CS527_12850	COG1846	Transcriptional regulator
CS527_12860	COG4974	Belongs to the 'phage' integrase family
CS527_12880	COG0531	amino acid
CS527_12885	COG4302	ethanolamine ammonia-lyase activity
CS527_12890	COG4303	Ethanolamine ammonia lyase large subunit
CS527_12895	COG4819	ethanolamine utilization protein
CS527_12905	COG0833	amino acid
CS527_12915	COG1247	-acetyltransferase
CS527_12920	COG1335	isochorismatase
CS527_12930	COG3403	YqcI/YcgG family
CS527_12935	COG1280	lysine exporter protein (LysE YggA)
CS527_12940	COG2267	carboxylic ester hydrolase activity
CS527_12945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CS527_12950	COG0187	DNA topoisomerase II activity
CS527_12955	COG1832	CoA-binding protein
CS527_12960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CS527_12965	COG4841	protein insertion into membrane
CS527_12970	COG0824	Thioesterase
CS527_13000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_13005	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CS527_13025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CS527_13060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CS527_13065	COG2068	MobA-Related Protein
CS527_13070	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CS527_13125	COG1183	phosphatidylcholine synthase activity
CS527_13140	COG2814	Major facilitator Superfamily
CS527_13145	COG1683	Conserved Protein
CS527_13150	COG1302	Protein conserved in bacteria
CS527_13165	COG1295	ribonuclease BN
CS527_13175	COG1115	amino acid carrier protein
CS527_13180	COG2814	Major facilitator Superfamily
CS527_13195	COG0789	Transcriptional regulator
CS527_13205	COG0288	reversible hydration of carbon dioxide
CS527_13210	COG0659	secondary active sulfate transmembrane transporter activity
CS527_13215	COG0745	RESPONSE REGULATOR receiver
CS527_13220	COG5002	protein histidine kinase activity
CS527_13230	COG0477	Major facilitator Superfamily
CS527_13235	COG4282	regulation of fungal-type cell wall biogenesis
CS527_13240	COG0531	amino acid
CS527_13250	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_13255	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CS527_13325	COG1363	Peptidase, m42
CS527_13335	COG1114	Component of the transport system for branched-chain amino acids
CS527_13355	COG0004	ammonium transporteR
CS527_13370	COG1252	NADH dehydrogenase
CS527_13375	COG0679	Auxin Efflux Carrier
CS527_13380	COG0281	malic enzyme
CS527_13385	COG1473	amidohydrolase
CS527_13390	COG2271	Major facilitator Superfamily
CS527_13410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CS527_13415	COG0163	prenyltransferase activity
CS527_13420	COG0583	DNA-binding transcription factor activity
CS527_13425	COG0679	Auxin Efflux Carrier
CS527_13445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_13450	COG0247	lactate metabolic process
CS527_13455	COG0277	FAD linked oxidase domain protein
CS527_13460	COG3835	regulator
CS527_13465	COG0693	protein deglycase activity
CS527_13475	COG2610	gluconate transmembrane transporter activity
CS527_13495	COG1131	(ABC) transporter
CS527_13505	COG2197	response regulator
CS527_13540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_13550	COG0586	Pfam SNARE associated Golgi protein
CS527_13555	COG1515	deoxyribonuclease V activity
CS527_13560	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_13565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_13565	COG3153	acetyltransferase
CS527_13575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CS527_13580	COG0531	amino acid
CS527_13715	COG0534	Mate efflux family protein
CS527_13720	COG1566	PFAM secretion protein HlyD family protein
CS527_13730	COG1846	Transcriptional regulator
CS527_13735	COG0708	Exodeoxyribonuclease III
CS527_13750	COG0673	inositol 2-dehydrogenase activity
CS527_13755	COG1349	DNA-binding transcription factor activity
CS527_13760	COG3853	Toxic anion resistance protein (TelA)
CS527_13770	COG2310	stress, protein
CS527_13775	COG2310	stress, protein
CS527_13780	COG2310	stress, protein
CS527_13785	COG0737	Belongs to the 5'-nucleotidase family
CS527_13805	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS527_13810	COG1131	(ABC) transporter
CS527_13820	COG2084	Dehydrogenase
CS527_13825	COG1278	Cold shock
CS527_13830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_13840	COG0028	Belongs to the TPP enzyme family
CS527_13845	COG1278	Cold shock
CS527_13870	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_13875	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_13885	COG0427	acetyl-CoA hydrolase
CS527_13890	COG3279	Response regulator of the LytR AlgR family
CS527_13895	COG2323	membrane
CS527_13900	COG2814	Major facilitator Superfamily
CS527_13905	COG3584	3D domain protein
CS527_13905	COG1388	LysM domain
CS527_13910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CS527_13935	COG3340	Belongs to the peptidase S51 family
CS527_13960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CS527_13990	COG2318	DinB family
CS527_14000	COG0579	oxidoreductase
CS527_14035	COG1486	melibiose metabolic process
CS527_14065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS527_14085	COG1929	Belongs to the glycerate kinase type-1 family
CS527_14090	COG2610	gluconate transmembrane transporter activity
CS527_14095	COG3835	regulator
CS527_14100	COG1454	alcohol dehydrogenase
CS527_14105	COG3152	Membrane
CS527_14130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_14135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_14140	COG3152	Membrane
CS527_14160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS527_14170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CS527_14185	COG2390	Transcriptional regulator
CS527_14215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CS527_14225	COG1695	Transcriptional regulator
CS527_14230	COG0501	Belongs to the peptidase M48B family
CS527_14235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_14240	COG1742	UPF0060 membrane protein
CS527_14245	COG2182	Extracellular solute-binding protein
CS527_14265	COG2031	fatty acid transporter
CS527_14295	COG2391	methyltransferase activity
CS527_14310	COG1979	alcohol dehydrogenase
CS527_14315	COG0583	DNA-binding transcription factor activity
CS527_14330	COG2211	Major facilitator Superfamily
CS527_14360	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_14365	COG1063	alcohol dehydrogenase
CS527_14390	COG0025	NhaP-type Na H and K H
CS527_14395	COG1253	flavin adenine dinucleotide binding
CS527_14405	COG4325	translation initiation factor activity
CS527_14420	COG4608	Belongs to the ABC transporter superfamily
CS527_14430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_14435	COG0601	transmembrane transport
CS527_14440	COG0747	negative chemotaxis
CS527_14450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_14470	COG1525	nuclease
CS527_14480	COG0579	oxidoreductase
CS527_14485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CS527_14490	COG0561	phosphatase activity
CS527_14505	COG0668	transmembrane transport
CS527_14535	COG2309	aminopeptidase activity
CS527_14540	COG1414	Transcriptional regulator
CS527_14545	COG0179	Fumarylacetoacetate (FAA) hydrolase
CS527_14550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CS527_14555	COG0277	FAD linked oxidase domain protein
CS527_14560	COG0247	lactate metabolic process
CS527_14565	COG0277	FAD linked oxidase domain protein
CS527_14570	COG1620	l-lactate permease
CS527_14590	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CS527_14595	COG1131	(ABC) transporter
CS527_14615	COG1595	DNA-templated transcription, initiation
CS527_14635	COG4682	membrane
CS527_14650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_14655	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_14660	COG0598	Magnesium transport protein CorA
CS527_14665	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CS527_14675	COG2323	membrane
CS527_14680	COG1876	peptidase activity
CS527_14695	COG5002	protein histidine kinase activity
CS527_14700	COG0745	RESPONSE REGULATOR receiver
CS527_14720	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_14735	COG2814	Major facilitator Superfamily
CS527_14740	COG1764	response to oxidative stress
CS527_14750	COG2311	Membrane
CS527_14800	COG0559	Belongs to the binding-protein-dependent transport system permease family
CS527_14810	COG0347	Belongs to the P(II) protein family
CS527_14815	COG0004	ammonium transporteR
CS527_14820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CS527_14835	COG0596	Alpha beta hydrolase
CS527_14855	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CS527_14855	COG0456	acetyltransferase
CS527_14860	COG1960	acyl-CoA dehydrogenase activity
CS527_14900	COG4604	ABC transporter, ATP-binding protein
CS527_14905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_14910	COG1492	cobalamin metabolic process
CS527_14920	COG0531	amino acid
CS527_14930	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_14935	COG2404	hydrolase activity, acting on ester bonds
CS527_14940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CS527_14950	COG1609	Transcriptional regulator
CS527_14960	COG2271	Major facilitator Superfamily
CS527_14965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_14980	COG1233	COG1233 Phytoene dehydrogenase and related
CS527_14985	COG0463	Glycosyl transferase, family 2
CS527_15030	COG0804	urea catabolic process
CS527_15040	COG0831	urea catabolic process
CS527_15045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CS527_15050	COG0791	NLP P60 protein
CS527_15050	COG1388	LysM domain
CS527_15055	COG1388	LysM domain
CS527_15055	COG3584	3D domain protein
CS527_15055	COG3584	3D domain protein
CS527_15055	COG1388	LysM domain
CS527_15060	COG0778	Nitroreductase
CS527_15065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CS527_15070	COG0586	Pfam SNARE associated Golgi protein
CS527_15080	COG0400	carboxylic ester hydrolase activity
CS527_15085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_15090	COG2244	polysaccharide biosynthetic process
CS527_15095	COG0697	spore germination
CS527_15100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_15120	COG1132	(ABC) transporter
CS527_15145	COG4195	phage-related replication protein
CS527_15155	COG0783	Belongs to the Dps family
CS527_15165	COG5577	PFAM Coat F domain
CS527_15170	COG1253	flavin adenine dinucleotide binding
CS527_15185	COG0516	GMP reductase activity
CS527_15185	COG0517	IMP dehydrogenase activity
CS527_15195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_15195	COG0723	plastoquinol--plastocyanin reductase activity
CS527_15210	COG0287	Prephenate dehydrogenase
CS527_15220	COG1605	Chorismate mutase
CS527_15220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CS527_15230	COG2059	Chromate
CS527_15235	COG2059	Chromate
CS527_15245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CS527_15250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_15255	COG2508	Transcriptional regulator
CS527_15260	COG0011	TIGRFAM Protein of
CS527_15265	COG0791	NLP P60 protein
CS527_15265	COG1388	LysM domain
CS527_15270	COG0753	catalase activity
CS527_15280	COG0733	neurotransmitter:sodium symporter activity
CS527_15320	COG0730	response to heat
CS527_15325	COG1902	pentaerythritol trinitrate reductase activity
CS527_15340	COG2205	protein histidine kinase activity
CS527_15375	COG0640	Transcriptional regulator
CS527_15385	COG0778	Nitroreductase
CS527_15400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CS527_15405	COG3103	Sh3 type 3 domain protein
CS527_15405	COG4991	sh3 domain protein
CS527_15405	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_15410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CS527_15415	COG2002	toxin-antitoxin pair type II binding
CS527_15420	COG2318	DinB family
CS527_15425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CS527_15435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CS527_15440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_15455	COG2211	Major facilitator Superfamily
CS527_15460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_15465	COG1597	lipid kinase activity
CS527_15475	COG0372	Belongs to the citrate synthase family
CS527_15480	COG0583	DNA-binding transcription factor activity
CS527_15485	COG0697	spore germination
CS527_15490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_15510	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_15510	COG2202	Pas domain
CS527_15515	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_15545	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_15550	COG2261	transglycosylase associated protein
CS527_15560	COG0740	serine-type endopeptidase activity
CS527_15575	COG1027	Aspartate ammonia-lyase
CS527_15580	COG0252	asparaginase activity
CS527_15585	COG1396	sequence-specific DNA binding
CS527_15600	COG0640	Transcriptional regulator
CS527_15620	COG0531	amino acid
CS527_15625	COG1959	2 iron, 2 sulfur cluster binding
CS527_15645	COG0281	malic enzyme
CS527_15650	COG2746	aminoglycoside 3-N-acetyltransferase activity
CS527_15660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_15665	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_15675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CS527_15680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CS527_15690	COG0477	Major facilitator Superfamily
CS527_15695	COG1846	Transcriptional regulator
CS527_15700	COG0789	Transcriptional regulator
CS527_15705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_15740	COG1819	glycosyl
CS527_15755	COG1902	pentaerythritol trinitrate reductase activity
CS527_15765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS527_15780	COG2814	Major facilitator Superfamily
CS527_15790	COG1228	amidohydrolase
CS527_15800	COG1316	TRANSCRIPTIONal
CS527_15805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_15825	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CS527_15835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CS527_15840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CS527_15905	COG1280	lysine exporter protein (LysE YggA)
CS527_15915	COG0531	amino acid
CS527_15930	COG3764	Sortase (surface protein transpeptidase)
CS527_15935	COG0730	response to heat
CS527_15940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_15945	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CS527_15955	COG2130	NADP-dependent
CS527_15980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_15995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CS527_16005	COG0501	Belongs to the peptidase M48B family
CS527_16040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CS527_16040	COG0131	Imidazoleglycerol-phosphate dehydratase
CS527_16055	COG2076	Multidrug Resistance protein
CS527_16060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CS527_16065	COG1278	Cold shock
CS527_16070	COG2323	membrane
CS527_16080	COG2910	NAD(P)H-binding
CS527_16110	COG3546	catalase activity
CS527_16115	COG4607	ABC-type enterochelin transport system periplasmic component
CS527_16120	COG4604	ABC transporter, ATP-binding protein
CS527_16125	COG4605	iron ion homeostasis
CS527_16130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_16135	COG3773	Cell wall hydrolase
CS527_16155	COG1063	alcohol dehydrogenase
CS527_16160	COG3775	system Galactitol-specific IIC component
CS527_16165	COG3414	Phosphotransferase system galactitol-specific IIB component
CS527_16170	COG3414	Phosphotransferase system galactitol-specific IIB component
CS527_16185	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_16210	COG1349	DNA-binding transcription factor activity
CS527_16225	COG1193	negative regulation of DNA recombination
CS527_16235	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CS527_16240	COG1396	sequence-specific DNA binding
CS527_16245	COG0861	Integral membrane protein TerC family
CS527_16250	COG1609	Transcriptional regulator
CS527_16255	COG1959	2 iron, 2 sulfur cluster binding
CS527_16315	COG3773	Cell wall hydrolase
CS527_16320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CS527_16350	COG3546	catalase activity
CS527_16370	COG1280	lysine exporter protein (LysE YggA)
CS527_16375	COG2207	Transcriptional regulator
CS527_16375	COG1917	Cupin 2, conserved barrel domain protein
CS527_16380	COG4585	Histidine kinase
CS527_16390	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_16405	COG3209	COG3209 Rhs family protein
CS527_16445	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CS527_16455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_16475	COG0346	lactoylglutathione lyase activity
CS527_16480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CS527_16495	COG1136	(ABC) transporter
CS527_16500	COG0577	efflux transmembrane transporter activity
CS527_16505	COG3850	Histidine kinase
CS527_16505	COG5002	protein histidine kinase activity
CS527_16530	COG5002	protein histidine kinase activity
CS527_16535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_16540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CS527_16565	COG4989	oxidoreductase activity
CS527_16575	COG0697	spore germination
CS527_16580	COG2207	Transcriptional regulator
CS527_16580	COG1917	Cupin 2, conserved barrel domain protein
CS527_16655	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CS527_16665	COG1301	dicarboxylic acid transport
CS527_16670	COG2824	Alkylphosphonate utilization operon protein PhnA
CS527_16700	COG0405	Gamma-glutamyltransferase
CS527_16705	COG1073	alpha beta
CS527_16720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_16725	COG4521	taurine ABC transporter
CS527_16730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CS527_16735	COG2175	clavaminate synthase activity
CS527_16740	COG2814	Major facilitator Superfamily
CS527_16760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_16770	COG1960	acyl-CoA dehydrogenase activity
CS527_16775	COG1063	alcohol dehydrogenase
CS527_16780	COG0745	RESPONSE REGULATOR receiver
CS527_16785	COG0642	Histidine kinase
CS527_16790	COG1136	(ABC) transporter
CS527_16795	COG0577	efflux transmembrane transporter activity
CS527_16805	COG0412	Dienelactone hydrolase
CS527_16810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_16825	COG0730	response to heat
CS527_16830	COG0425	Belongs to the sulfur carrier protein TusA family
CS527_16835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_16835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_16840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_16840	COG0425	Belongs to the sulfur carrier protein TusA family
CS527_16850	COG2210	Belongs to the sulfur carrier protein TusA family
CS527_16860	COG1937	Protein conserved in bacteria
CS527_16880	COG0583	DNA-binding transcription factor activity
CS527_16895	COG2188	Transcriptional regulator
CS527_16905	COG2723	6-phospho-beta-galactosidase activity
CS527_16930	COG1280	lysine exporter protein (LysE YggA)
CS527_16945	COG0583	DNA-binding transcription factor activity
CS527_16950	COG2814	Major facilitator Superfamily
CS527_16955	COG0346	lactoylglutathione lyase activity
CS527_16980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CS527_16995	COG0778	Nitroreductase
CS527_17000	COG1012	belongs to the aldehyde dehydrogenase family
CS527_17020	COG1704	LemA family
CS527_17025	COG0726	polysaccharide deacetylase
CS527_17040	COG1733	regulation of RNA biosynthetic process
CS527_17045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_17050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_17055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CS527_17070	COG2304	oxidoreductase activity
CS527_17080	COG0346	lactoylglutathione lyase activity
CS527_17085	COG2808	Putative FMN-binding domain
CS527_17120	COG4807	Protein conserved in bacteria
CS527_17130	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CS527_17140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_17145	COG1278	Cold shock
CS527_17150	COG1278	Cold shock
CS527_17165	COG0747	negative chemotaxis
CS527_17170	COG0601	transmembrane transport
CS527_17175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CS527_17180	COG0444	Belongs to the ABC transporter superfamily
CS527_17185	COG4608	Belongs to the ABC transporter superfamily
CS527_17195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CS527_17200	COG1301	dicarboxylic acid transport
CS527_17215	COG0477	Major facilitator Superfamily
CS527_17260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_17265	COG0659	secondary active sulfate transmembrane transporter activity
CS527_17275	COG2211	Major facilitator Superfamily
CS527_17280	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CS527_17285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CS527_17290	COG1691	(AIR) carboxylase
CS527_17295	COG1606	tRNA processing
CS527_17300	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_17310	COG1904	glucuronate isomerase
CS527_17360	COG0561	phosphatase activity
CS527_17370	COG2312	Erythromycin esterase
CS527_17385	COG2329	Antibiotic biosynthesis monooxygenase
CS527_17425	COG3655	Transcriptional regulator
CS527_17435	COG0583	DNA-binding transcription factor activity
CS527_17440	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_17455	COG1609	Transcriptional regulator
CS527_17460	COG1082	Xylose isomerase domain protein TIM barrel
CS527_17465	COG0673	inositol 2-dehydrogenase activity
CS527_17485	COG3718	enzyme involved in inositol metabolism
CS527_17490	COG3962	Belongs to the TPP enzyme family
CS527_17495	COG1349	DNA-binding transcription factor activity
CS527_17500	COG0191	fructose-bisphosphate aldolase activity
CS527_17505	COG1082	Xylose isomerase domain protein TIM barrel
CS527_17510	COG2814	Major facilitator Superfamily
CS527_17525	COG1064	alcohol dehydrogenase
CS527_17530	COG0789	Transcriptional regulator
CS527_17545	COG0662	Cupin 2, conserved barrel domain protein
CS527_17565	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_17570	COG1278	Cold shock
CS527_17585	COG1876	peptidase activity
CS527_17605	COG0598	Magnesium transport protein CorA
CS527_17610	COG1366	Belongs to the anti-sigma-factor antagonist family
CS527_17620	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_17630	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_17645	COG4335	DNA alkylation repair
CS527_17650	COG0454	-acetyltransferase
CS527_17670	COG2814	Major facilitator Superfamily
CS527_17675	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_17675	COG3848	Pyruvate phosphate dikinase
CS527_17680	COG3848	Pyruvate phosphate dikinase
CS527_17680	COG0574	Belongs to the PEP-utilizing enzyme family
CS527_17695	COG2186	Transcriptional regulator
CS527_17715	COG3619	membrane
CS527_17725	COG1349	DNA-binding transcription factor activity
CS527_17730	COG0561	phosphatase activity
CS527_17740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS527_17755	COG1280	lysine exporter protein (LysE YggA)
CS527_17780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CS527_17795	COG2814	Major facilitator Superfamily
CS527_17800	COG2160	L-arabinose isomerase activity
CS527_17815	COG1609	Transcriptional regulator
CS527_17820	COG1078	dGTPase activity
CS527_17840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS527_17845	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS527_17850	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CS527_17850	COG1918	ferrous iron import across plasma membrane
CS527_17880	COG1846	Transcriptional regulator
CS527_17915	COG0697	spore germination
CS527_17920	COG0791	NLP P60 protein
CS527_17920	COG1388	LysM domain
CS527_17925	COG2258	MOSC domain
CS527_17930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CS527_17965	COG4974	Belongs to the 'phage' integrase family
CS527_18005	COG1309	transcriptional regulator
CS527_18010	COG3844	kynureninase activity
CS527_18015	COG1113	amino acid transport
CS527_18020	COG3483	tryptophan 2,3-dioxygenase activity
CS527_18025	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CS527_18030	COG1942	4-Oxalocrotonate Tautomerase
CS527_18060	COG0251	oxidation-reduction process
CS527_18075	COG0431	NADPH-dependent FMN reductase
CS527_18080	COG0196	riboflavin kinase activity
CS527_18085	COG2368	4-hydroxyphenylacetate
CS527_18105	COG0789	Transcriptional regulator
CS527_18140	COG5646	InterPro IPR014922
CS527_18180	COG2814	Major facilitator Superfamily
CS527_18190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CS527_18200	COG2258	MOSC domain
CS527_18215	COG0477	Major facilitator Superfamily
CS527_18220	COG0583	DNA-binding transcription factor activity
CS527_18225	COG2070	2-Nitropropane dioxygenase
CS527_18230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CS527_18255	COG2271	Major facilitator Superfamily
CS527_18260	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_18270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CS527_18275	COG1414	Transcriptional regulator
CS527_18285	COG1476	TRANSCRIPTIONal
CS527_18320	COG1012	belongs to the aldehyde dehydrogenase family
CS527_18335	COG1501	Belongs to the glycosyl hydrolase 31 family
CS527_18345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CS527_18355	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CS527_18365	COG0300	oxidoreductase activity
CS527_18375	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_18375	COG0596	Alpha beta hydrolase
CS527_18380	COG1309	transcriptional regulator
CS527_18385	COG1733	regulation of RNA biosynthetic process
CS527_18390	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_18395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CS527_18400	COG2226	methyltransferase
CS527_18415	COG1942	4-Oxalocrotonate Tautomerase
CS527_18420	COG0583	DNA-binding transcription factor activity
CS527_18425	COG0047	phosphoribosylformylglycinamidine synthase activity
CS527_18430	COG1522	sequence-specific DNA binding
CS527_18440	COG2267	carboxylic ester hydrolase activity
CS527_18450	COG1335	isochorismatase
CS527_18460	COG0346	lactoylglutathione lyase activity
CS527_18465	COG2259	Doxx family
CS527_18470	COG0039	L-malate dehydrogenase activity
CS527_18480	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CS527_18495	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CS527_18500	COG1454	alcohol dehydrogenase
CS527_18500	COG1012	belongs to the aldehyde dehydrogenase family
CS527_18505	COG4816	utilization protein
CS527_18510	COG4302	ethanolamine ammonia-lyase activity
CS527_18515	COG4303	Ethanolamine ammonia lyase large subunit
CS527_18525	COG4917	ethanolamine utilization protein
CS527_18530	COG4810	utilization protein
CS527_18535	COG3192	ethanolamine utilization protein
CS527_18565	COG1309	transcriptional regulator
CS527_18570	COG2076	Multidrug Resistance protein
CS527_18580	COG0477	Major facilitator Superfamily
CS527_18585	COG1609	Transcriptional regulator
CS527_18590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CS527_18610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CS527_18620	COG2851	Citrate transporter
CS527_18630	COG0477	Major facilitator Superfamily
CS527_18640	COG0477	Major facilitator Superfamily
CS527_18645	COG1309	transcriptional regulator
CS527_18665	COG2318	DinB family
CS527_18670	COG0156	8-amino-7-oxononanoate synthase activity
CS527_18675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CS527_18690	COG1378	Sugar-specific transcriptional regulator TrmB
CS527_18695	COG0697	spore germination
CS527_18705	COG0583	DNA-binding transcription factor activity
CS527_18745	COG1266	CAAX protease self-immunity
CS527_18765	COG0252	asparaginase activity
CS527_18785	COG1695	Transcriptional regulator
CS527_18795	COG0656	L-ascorbic acid biosynthetic process
CS527_18805	COG0583	DNA-binding transcription factor activity
CS527_18815	COG2814	Major facilitator Superfamily
CS527_18825	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CS527_18835	COG0281	malic enzyme
CS527_18840	COG2404	hydrolase activity, acting on ester bonds
CS527_18900	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CS527_18970	COG3339	Conserved Protein
CS527_18985	COG3708	Transcriptional regulator
CS527_18985	COG2207	Transcriptional regulator
CS527_19000	COG1357	PFAM Pentapeptide repeats (8 copies)
CS527_19010	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_19015	COG1733	regulation of RNA biosynthetic process
CS527_19045	COG0303	'Molybdopterin
CS527_19055	COG0521	Mo-molybdopterin cofactor biosynthetic process
CS527_19060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CS527_19090	COG2244	polysaccharide biosynthetic process
CS527_19110	COG2828	Protein conserved in bacteria
CS527_19115	COG0583	DNA-binding transcription factor activity
CS527_19120	COG2851	Citrate transporter
CS527_19135	COG0670	Belongs to the BI1 family
CS527_19155	COG0791	NLP P60 protein
CS527_19160	COG2814	Major facilitator Superfamily
CS527_19165	COG1846	Transcriptional regulator
CS527_19185	COG1278	Cold shock
CS527_19200	COG1113	amino acid transport
CS527_19205	COG1113	amino acid transport
CS527_19210	COG1012	belongs to the aldehyde dehydrogenase family
CS527_19215	COG0506	proline dehydrogenase activity
CS527_19220	COG3878	Protein conserved in bacteria
CS527_19235	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_19240	COG3300	MHYT domain
CS527_19240	COG5001	Diguanylate cyclase
CS527_19290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CS527_19295	COG5609	conserved protein (DUF2294)
CS527_19300	COG3223	Belongs to the PsiE family
CS527_19305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CS527_19330	COG0454	-acetyltransferase
CS527_19345	COG0789	Transcriptional regulator
CS527_19350	COG0667	Aldo Keto reductase
CS527_19360	COG0789	Transcriptional regulator
CS527_19385	COG1621	beta-fructofuranosidase activity
CS527_19390	COG4980	gas vesicle protein
CS527_19415	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS527_19420	COG0577	efflux transmembrane transporter activity
CS527_19425	COG1136	(ABC) transporter
CS527_19435	COG0642	Histidine kinase
CS527_19440	COG0745	RESPONSE REGULATOR receiver
CS527_19450	COG1289	transmembrane transporter activity
CS527_19455	COG1937	Protein conserved in bacteria
CS527_19460	COG3209	COG3209 Rhs family protein
CS527_19470	COG3973	AAA domain
CS527_19475	COG1024	Enoyl-CoA hydratase
CS527_19480	COG1733	regulation of RNA biosynthetic process
CS527_19495	COG2124	cytochrome p450
CS527_19500	COG2259	Doxx family
CS527_19505	COG0463	Glycosyl transferase, family 2
CS527_19515	COG0463	Glycosyl transferase, family 2
CS527_19530	COG1388	LysM domain
CS527_19530	COG0791	NLP P60 protein
CS527_19535	COG0840	transmembrane signaling receptor activity
CS527_19540	COG1846	Transcriptional regulator
CS527_19550	COG1595	DNA-templated transcription, initiation
CS527_19555	COG0726	polysaccharide deacetylase
CS527_19575	COG0833	amino acid
CS527_19585	COG0405	Gamma-glutamyltransferase
CS527_19605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CS527_19610	COG0569	domain protein
CS527_19620	COG1522	sequence-specific DNA binding
CS527_19630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS527_19635	COG0745	RESPONSE REGULATOR receiver
CS527_19640	COG2770	Histidine kinase
CS527_19640	COG2205	protein histidine kinase activity
CS527_19645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CS527_19650	COG1607	acyl-coa hydrolase
CS527_19655	COG1802	Transcriptional regulator
CS527_19660	COG0697	spore germination
CS527_19670	COG0006	proline dipeptidase activity
CS527_19680	COG1316	TRANSCRIPTIONal
CS527_19690	COG2249	NAD(P)H dehydrogenase (quinone) activity
CS527_19695	COG5522	Integral membrane protein (intg_mem_TP0381)
CS527_19700	COG1174	glycine betaine transport
CS527_19705	COG0517	IMP dehydrogenase activity
CS527_19705	COG1125	glycine betaine transport
CS527_19720	COG2814	Major facilitator Superfamily
CS527_19730	COG0395	ABC-type sugar transport system, permease component
CS527_19755	COG2205	protein histidine kinase activity
CS527_19760	COG0730	response to heat
CS527_19765	COG1301	dicarboxylic acid transport
CS527_19805	COG1368	sulfuric ester hydrolase activity
CS527_19815	COG0697	spore germination
CS527_19820	COG1902	pentaerythritol trinitrate reductase activity
CS527_19835	COG1113	amino acid transport
CS527_19840	COG5505	Protein of unknown function (DUF819)
CS527_19845	COG1309	transcriptional regulator
CS527_19855	COG0583	DNA-binding transcription factor activity
CS527_19860	COG0730	response to heat
CS527_19865	COG1247	-acetyltransferase
CS527_19870	COG2910	NAD(P)H-binding
CS527_19875	COG1285	pathogenesis
CS527_19880	COG2226	methyltransferase
CS527_19885	COG4195	phage-related replication protein
CS527_19890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CS527_19905	COG1113	amino acid transport
CS527_19935	COG0463	Glycosyl transferase, family 2
CS527_19965	COG2514	catechol 2,3-dioxygenase activity
CS527_19985	COG1280	lysine exporter protein (LysE YggA)
CS527_19990	COG1115	amino acid carrier protein
CS527_20000	COG0385	Bile acid
CS527_20005	COG0668	transmembrane transport
CS527_20010	COG2340	Cysteine-rich secretory protein family
CS527_20015	COG1253	flavin adenine dinucleotide binding
CS527_20025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CS527_20030	COG0589	response to stress
CS527_20035	COG0205	6-phosphofructokinase activity
CS527_20040	COG1388	LysM domain
CS527_20040	COG0791	NLP P60 protein
CS527_20050	COG0432	Pfam Uncharacterised protein family UPF0047
CS527_20055	COG0697	spore germination
CS527_20060	COG0814	amino acid
CS527_20085	COG1131	(ABC) transporter
CS527_20100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CS527_20115	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_20125	COG1131	(ABC) transporter
CS527_20150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_20150	COG1263	PTS System
CS527_20155	COG3711	transcriptional antiterminator
CS527_20160	COG2190	(PTS) system
CS527_20165	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CS527_20180	COG0772	Belongs to the SEDS family
CS527_20185	COG0659	secondary active sulfate transmembrane transporter activity
CS527_20190	COG0813	purine-nucleoside phosphorylase activity
CS527_20200	COG0671	phosphoesterase, PA-phosphatase related
CS527_20205	COG4326	sporulation control protein
CS527_20210	COG2815	serine threonine protein kinase
CS527_20210	COG0515	serine threonine protein kinase
CS527_20230	COG4479	Belongs to the UPF0346 family
CS527_20235	COG3594	Acyltransferase
CS527_20250	COG1509	lysine 2,3-aminomutase activity
CS527_20255	COG0456	acetyltransferase
CS527_20260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_20265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS527_20270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS527_20275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_20280	COG1301	dicarboxylic acid transport
CS527_20290	COG4191	Histidine kinase
CS527_20315	COG2755	lipolytic protein G-D-S-L family
CS527_20320	COG1999	signal sequence binding
CS527_20330	COG1307	EDD domain protein, DegV family
CS527_20340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CS527_20350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CS527_20355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CS527_20360	COG0788	formyltetrahydrofolate deformylase activity
CS527_20390	COG0076	glutamate decarboxylase activity
CS527_20410	COG0415	Belongs to the DNA photolyase family
CS527_20415	COG3852	Histidine kinase
CS527_20430	COG1012	belongs to the aldehyde dehydrogenase family
CS527_20440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CS527_20450	COG4846	Membrane protein involved in cytochrome C biogenesis
CS527_20455	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CS527_20460	COG0785	Cytochrome C biogenesis protein
CS527_20470	COG1132	(ABC) transporter
CS527_20475	COG1132	(ABC) transporter
CS527_20495	COG4224	UPF0291 protein
CS527_20500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CS527_20525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CS527_20530	COG0531	amino acid
CS527_20540	COG0174	glutamine synthetase
CS527_20545	COG0789	Transcriptional regulator
CS527_20550	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CS527_20555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CS527_20560	COG2860	membrane
CS527_20565	COG0464	growth
CS527_20575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CS527_20585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CS527_20590	COG0531	amino acid
CS527_20600	COG4550	Control of competence regulator ComK, YlbF/YmcA
CS527_20605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS527_20610	COG1013	pyruvate-flavodoxin oxidoreductase activity
CS527_20615	COG0674	pyruvate-flavodoxin oxidoreductase activity
CS527_20615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CS527_20625	COG2359	stage V sporulation protein S
CS527_20630	COG1692	metallophosphoesterase
CS527_20640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CS527_20645	COG1546	Belongs to the CinA family
CS527_20645	COG1058	Belongs to the CinA family
CS527_20650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CS527_20655	COG1426	Protein conserved in bacteria
CS527_20670	COG0300	oxidoreductase activity
CS527_20675	COG0612	Peptidase, M16
CS527_20680	COG0612	Peptidase, M16
CS527_20705	COG2188	Transcriptional regulator
CS527_20710	COG1674	ftsk spoiiie
CS527_20710	COG4980	gas vesicle protein
CS527_20720	COG0740	serine-type endopeptidase activity
CS527_20725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CS527_20735	COG0527	aspartate kinase activity
CS527_20740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CS527_20745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CS527_20750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS527_20755	COG1873	PFAM PRC-barrel domain
CS527_20760	COG0612	Peptidase, M16
CS527_20765	COG0726	polysaccharide deacetylase
CS527_20770	COG1185	polyribonucleotide nucleotidyltransferase activity
CS527_20775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CS527_20780	COG0196	riboflavin kinase activity
CS527_20795	COG1550	Protein conserved in bacteria
CS527_20805	COG1358	cellular component organization or biogenesis
CS527_20810	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CS527_20815	COG0195	Participates in both transcription termination and antitermination
CS527_20820	COG0779	Required for maturation of 30S ribosomal subunits
CS527_20825	COG2176	DNA-directed DNA polymerase activity
CS527_20830	COG0442	prolyl-tRNA aminoacylation
CS527_20835	COG0750	zinc metalloprotease
CS527_20845	COG4589	Belongs to the CDS family
CS527_20855	COG0233	cytoplasmic translational termination
CS527_20860	COG0528	UMP kinase activity
CS527_20865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CS527_20880	COG1191	sigma factor activity
CS527_20885	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CS527_20890	COG0835	chemotaxis
CS527_20895	COG0643	Histidine kinase
CS527_20895	COG2198	Histidine kinase
CS527_20900	COG2201	protein-glutamate methylesterase activity
CS527_20905	COG0455	bacterial-type flagellum organization
CS527_20910	COG1419	protein localization to endoplasmic reticulum
CS527_20915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CS527_20920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CS527_20925	COG1684	flagellar biosynthetic protein fliR
CS527_20930	COG1987	bacterial-type flagellum assembly
CS527_20935	COG1338	Plays a role in the flagellum-specific transport system
CS527_20940	COG3190	flagellar
CS527_20945	COG2201	protein-glutamate methylesterase activity
CS527_20950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS527_20950	COG1776	CheC inhibitor of MCP methylation
CS527_20955	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS527_20965	COG1582	Flagellar protein (FlbD)
CS527_20970	COG4786	Flagellar basal body rod
CS527_20975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CS527_20990	COG2882	bacterial-type flagellum organization
CS527_20995	COG1157	protein secretion by the type III secretion system
CS527_21000	COG1317	bacterial-type flagellum organization
CS527_21005	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CS527_21010	COG1766	The M ring may be actively involved in energy transduction
CS527_21015	COG1677	Flagellar hook-basal body complex protein FliE
CS527_21020	COG1558	bacterial-type flagellum-dependent cell motility
CS527_21025	COG1815	bacterial-type flagellum-dependent cell motility
CS527_21030	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CS527_21035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CS527_21045	COG4974	Belongs to the 'phage' integrase family
CS527_21055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CS527_21060	COG0758	DNA mediated transformation
CS527_21065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CS527_21070	COG0045	succinate-CoA ligase (ADP-forming) activity
CS527_21090	COG0335	large ribosomal subunit rRNA binding
CS527_21100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CS527_21110	COG1837	Belongs to the UPF0109 family
CS527_21115	COG0228	four-way junction DNA binding
CS527_21120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CS527_21130	COG0552	protein localization to endoplasmic reticulum
CS527_21135	COG1196	nuclear chromosome segregation
CS527_21145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CS527_21150	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_21155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CS527_21160	COG0416	fatty acid biosynthetic process
CS527_21165	COG1349	DNA-binding transcription factor activity
CS527_21170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CS527_21175	COG1760	l-serine dehydratase
CS527_21180	COG1760	l-serine dehydratase
CS527_21190	COG1461	Dihydroxyacetone kinase
CS527_21195	COG1302	Protein conserved in bacteria
CS527_21200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CS527_21210	COG1564	THIamine pyrophosphokinase
CS527_21215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CS527_21220	COG1162	GTPase activity
CS527_21225	COG0515	serine threonine protein kinase
CS527_21225	COG2815	serine threonine protein kinase
CS527_21230	COG0631	protein serine/threonine phosphatase activity
CS527_21240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CS527_21240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS527_21245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CS527_21255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CS527_21260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CS527_21265	COG1758	RNA polymerase activity
CS527_21270	COG0194	GDP metabolic process
CS527_21275	COG2052	Domain of unknown function (DUF370)
CS527_21280	COG1561	YicC-like family, N-terminal region
CS527_21285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CS527_21295	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CS527_21325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CS527_21340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CS527_21345	COG0564	pseudouridine synthase activity
CS527_21350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CS527_21365	COG3599	regulation of cell shape
CS527_21370	COG2302	S4 RNA-binding domain
CS527_21375	COG0762	integral membrane protein
CS527_21380	COG1799	cell septum assembly
CS527_21385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CS527_21395	COG1873	PFAM PRC-barrel domain
CS527_21400	COG1191	sigma factor activity
CS527_21405	COG1191	sigma factor activity
CS527_21415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CS527_21420	COG0849	cell division
CS527_21425	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CS527_21430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CS527_21435	COG0772	Belongs to the SEDS family
CS527_21440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CS527_21445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS527_21450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CS527_21455	COG0768	penicillin binding
CS527_21465	COG4839	cell division protein FtsL
CS527_21475	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CS527_21485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CS527_21490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS527_21495	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CS527_21500	COG0439	Biotin carboxylase
CS527_21505	COG0454	-acetyltransferase
CS527_21515	COG1024	Enoyl-CoA hydratase
CS527_21520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CS527_21525	COG1399	metal-binding, possibly nucleic acid-binding protein
CS527_21530	COG1323	Belongs to the UPF0348 family
CS527_21535	COG3480	Lon protease (S16) C-terminal proteolytic domain
CS527_21540	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS527_21545	COG3314	Sporulation integral membrane protein YlbJ
CS527_21550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CS527_21555	COG0742	ribosomal rna small subunit methyltransferase
CS527_21565	COG4471	UPF0298 protein
CS527_21575	COG3679	Belongs to the UPF0342 family
CS527_21595	COG4347	Protein of unknown function (DUF1405)
CS527_21605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CS527_21620	COG5582	Belongs to the UPF0302 family
CS527_21625	COG0457	Tetratricopeptide repeat
CS527_21630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CS527_21635	COG0287	Prephenate dehydrogenase
CS527_21640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CS527_21645	COG0159	tryptophan synthase activity
CS527_21655	COG0135	phosphoribosylanthranilate isomerase activity
CS527_21660	COG0134	indole-3-glycerol-phosphate synthase activity
CS527_21665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CS527_21675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CS527_21680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CS527_21685	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CS527_21690	COG0105	UTP biosynthetic process
CS527_21695	COG0142	geranyltranstransferase activity
CS527_21700	COG2226	methyltransferase
CS527_21705	COG0142	geranyltranstransferase activity
CS527_21715	COG0302	gtp cyclohydrolase
CS527_21720	COG0776	regulation of translation
CS527_21725	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CS527_21760	COG2271	Major facilitator Superfamily
CS527_21765	COG1304	FMN binding
CS527_21770	COG0539	negative regulation of cytoplasmic translation
CS527_21780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CS527_21790	COG2959	enzyme of heme biosynthesis
CS527_21795	COG3773	Cell wall hydrolase
CS527_21795	COG3409	Peptidoglycan-binding domain 1 protein
CS527_21800	COG2339	peptidase activity
CS527_21805	COG0252	asparaginase activity
CS527_21810	COG0492	ferredoxin-NADP+ reductase activity
CS527_21815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CS527_21820	COG4862	establishment of competence for transformation
CS527_21825	COG0789	Transcriptional regulator
CS527_21830	COG1408	metallophosphoesterase
CS527_21845	COG1266	CAAX protease self-immunity
CS527_21860	COG1141	Ferredoxin
CS527_21865	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CS527_21870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CS527_21875	COG0739	heme binding
CS527_21880	COG5002	protein histidine kinase activity
CS527_21885	COG0745	RESPONSE REGULATOR receiver
CS527_21890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS527_21895	COG1333	cytochrome c biogenesis protein
CS527_21900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_21905	COG1187	pseudouridine synthase activity
CS527_21910	COG0700	Nucleoside recognition
CS527_21915	COG2715	membrane protein required for spore maturation
CS527_21920	COG1686	Belongs to the peptidase S11 family
CS527_21925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CS527_21930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CS527_21940	COG1547	Domain of unknown function (DUF309)
CS527_21950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CS527_21955	COG4086	secreted protein
CS527_21965	COG0697	spore germination
CS527_21980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CS527_22015	COG1686	Belongs to the peptidase S11 family
CS527_22030	COG4974	Belongs to the 'phage' integrase family
CS527_22040	COG0735	belongs to the Fur family
CS527_22045	COG1300	Membrane
CS527_22050	COG0494	nUDIX hydrolase
CS527_22060	COG0667	Aldo Keto reductase
CS527_22070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CS527_22075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CS527_22085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS527_22090	COG1073	alpha beta
CS527_22105	COG0300	oxidoreductase activity
CS527_22110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_22115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS527_22120	COG1902	pentaerythritol trinitrate reductase activity
CS527_22130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CS527_22135	COG1012	belongs to the aldehyde dehydrogenase family
CS527_22140	COG2508	Transcriptional regulator
CS527_22160	COG0167	dihydroorotate dehydrogenase activity
CS527_22160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CS527_22165	COG0493	'glutamate synthase
CS527_22170	COG2195	Cleaves the N-terminal amino acid of tripeptides
CS527_22175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CS527_22180	COG0346	lactoylglutathione lyase activity
CS527_22185	COG1376	ErfK ybiS ycfS ynhG family protein
CS527_22190	COG4129	membrane
CS527_22195	COG1126	abc transporter atp-binding protein
CS527_22200	COG0765	amino acid transport
CS527_22205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CS527_22215	COG1703	isobutyryl-CoA mutase activity
CS527_22220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_22220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_22230	COG0508	dehydrogenase complex catalyzes the overall conversion of
CS527_22235	COG0022	dehydrogenase e1 component
CS527_22240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CS527_22245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CS527_22260	COG0280	phosphate acetyltransferase
CS527_22265	COG3290	protein histidine kinase activity
CS527_22265	COG3829	transcription factor binding
CS527_22275	COG0584	glycerophosphoryl diester phosphodiesterase
CS527_22280	COG3093	addiction module antidote protein HigA
CS527_22285	COG3104	oligopeptide transport
CS527_22290	COG0745	RESPONSE REGULATOR receiver
CS527_22295	COG0750	zinc metalloprotease
CS527_22300	COG0497	DNA recombination
CS527_22310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CS527_22325	COG1722	exodeoxyribonuclease VII activity
CS527_22335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CS527_22340	COG1302	Protein conserved in bacteria
CS527_22345	COG0439	Biotin carboxylase
CS527_22350	COG0511	ligase activity, forming carbon-carbon bonds
CS527_22390	COG3854	ATPases associated with a variety of cellular activities
CS527_22400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CS527_22405	COG0006	proline dipeptidase activity
CS527_22410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CS527_22420	COG3872	metal-dependent enzyme
CS527_22430	COG1752	Esterase of the alpha-beta hydrolase superfamily
CS527_22435	COG1321	iron dependent repressor
CS527_22440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_22445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_22450	COG0095	Lipoate-protein ligase
CS527_22455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_22465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CS527_22470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CS527_22475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CS527_22505	COG4970	Tfp pilus assembly protein FimT
CS527_22510	COG4537	Required for transformation and DNA binding
CS527_22515	COG1459	type II secretion system
CS527_22520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CS527_22525	COG1393	Belongs to the ArsC family
CS527_22535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_22545	COG2866	Carboxypeptidase
CS527_22550	COG1940	carbohydrate kinase activity
CS527_22555	COG4483	Protein conserved in bacteria
CS527_22560	COG0457	Tetratricopeptide repeat
CS527_22560	COG0705	Rhomboid family
CS527_22570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CS527_22580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CS527_22595	COG0704	Plays a role in the regulation of phosphate uptake
CS527_22610	COG0477	Major facilitator Superfamily
CS527_22645	COG2839	Protein conserved in bacteria
CS527_22655	COG2814	Major facilitator Superfamily
CS527_22660	COG1388	LysM domain
CS527_22665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CS527_22670	COG4709	membrane
CS527_22675	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CS527_22680	COG0735	belongs to the Fur family
CS527_22685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CS527_22690	COG1121	(ABC) transporter
CS527_22700	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CS527_22705	COG0513	Belongs to the DEAD box helicase family
CS527_22715	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CS527_22720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CS527_22725	COG2384	SAM-dependent methyltransferase
CS527_22730	COG2010	Cytochrome c
CS527_22735	COG1960	acyl-CoA dehydrogenase activity
CS527_22740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CS527_22745	COG0358	DNA primase activity
CS527_22750	COG1671	Belongs to the UPF0178 family
CS527_22755	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CS527_22760	COG0517	IMP dehydrogenase activity
CS527_22775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CS527_22780	COG0295	cytidine deaminase activity
CS527_22785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CS527_22795	COG1480	7TM receptor with intracellular HD hydrolase
CS527_22800	COG1702	phosphate starvation-inducible protein PhoH
CS527_22825	COG1030	water channel activity
CS527_22830	COG1610	YqeY-like protein
CS527_22835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CS527_22840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CS527_22845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CS527_22850	COG2264	protein methyltransferase activity
CS527_22865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CS527_22870	COG1420	regulation of RNA biosynthetic process
CS527_22875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CS527_22880	COG0481	GTPase activity
CS527_22890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CS527_22895	COG0268	Binds directly to 16S ribosomal RNA
CS527_22900	COG1466	dna polymerase III delta subunit
CS527_22910	COG2333	competence protein COMEC
CS527_22910	COG0658	competence protein
CS527_22915	COG2131	deaminase
CS527_22920	COG1596	polysaccharide export
CS527_22920	COG1555	photosystem II stabilization
CS527_22925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CS527_22930	COG2226	methyltransferase
CS527_22935	COG0799	negative regulation of ribosome biogenesis
CS527_22940	COG1713	HD superfamily hydrolase involved in NAD metabolism
CS527_22945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CS527_22950	COG1534	Rna-binding protein
CS527_22955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CS527_22960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CS527_22965	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CS527_22975	COG0688	phosphatidylethanolamine metabolic process
CS527_22980	COG1183	phosphatidylcholine synthase activity
CS527_22985	COG1191	sigma factor activity
CS527_23000	COG0626	cystathionine gamma-synthase activity
CS527_23005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CS527_23010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CS527_23015	COG2226	methyltransferase
CS527_23030	COG0768	penicillin binding
CS527_23035	COG1335	isochorismatase
CS527_23040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CS527_23045	COG0572	uridine kinase
CS527_23065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CS527_23070	COG3906	Belongs to the UPF0473 family
CS527_23080	COG4472	Bacterial protein of unknown function (DUF965)
CS527_23090	COG0628	permease
CS527_23105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CS527_23115	COG0482	sulfurtransferase activity
CS527_23120	COG1104	cysteine desulfurase activity
CS527_23125	COG1959	2 iron, 2 sulfur cluster binding
CS527_23130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CS527_23135	COG0581	inorganic phosphate transmembrane transporter activity
CS527_23140	COG0573	inorganic phosphate transmembrane transporter activity
CS527_23145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CS527_23150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CS527_23160	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CS527_23165	COG0124	histidyl-tRNA synthetase
CS527_23175	COG0860	N-Acetylmuramoyl-L-alanine amidase
CS527_23180	COG1490	D-aminoacyl-tRNA deacylase activity
CS527_23185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CS527_23190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CS527_23195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CS527_23195	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CS527_23200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS527_23200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CS527_23210	COG2244	polysaccharide biosynthetic process
CS527_23215	COG2323	membrane
CS527_23225	COG1862	Preprotein translocase
CS527_23235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CS527_23245	COG2255	four-way junction helicase activity
CS527_23275	COG1388	LysM domain
CS527_23280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CS527_23285	COG0157	Belongs to the NadC ModD family
CS527_23290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CS527_23295	COG1104	cysteine desulfurase activity
CS527_23300	COG1827	regulation of RNA biosynthetic process
CS527_23305	COG0077	Prephenate dehydratase
CS527_23310	COG4492	Belongs to the UPF0735 family
CS527_23315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CS527_23320	COG3290	protein histidine kinase activity
CS527_23330	COG2868	ribosomal protein
CS527_23340	COG1530	ribonuclease E activity
CS527_23345	COG1994	Peptidase M50
CS527_23350	COG0739	heme binding
CS527_23355	COG2894	cell division
CS527_23360	COG0850	regulation of cytokinetic process
CS527_23365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CS527_23370	COG1792	Involved in formation and maintenance of cell shape
CS527_23375	COG1077	Cell shape determining protein MreB Mrl
CS527_23380	COG2003	Belongs to the UPF0758 family
CS527_23385	COG0424	maF-like protein
CS527_23395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CS527_23405	COG2322	membrane
CS527_23410	COG0285	dihydrofolate synthase activity
CS527_23415	COG0525	valine-tRNA ligase activity
CS527_23425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS527_23430	COG1388	LysM domain
CS527_23435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CS527_23440	COG0113	porphobilinogen synthase activity
CS527_23445	COG1587	Uroporphyrinogen-III synthase
CS527_23450	COG0181	hydroxymethylbilane synthase activity
CS527_23455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CS527_23470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CS527_23475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CS527_23480	COG0470	DNA polymerase III
CS527_23480	COG1067	ATP-dependent peptidase activity
CS527_23485	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CS527_23490	COG0544	peptidyl-prolyl cis-trans isomerase activity
CS527_23495	COG1477	protein flavinylation
CS527_23495	COG0457	Tetratricopeptide repeat
CS527_23500	COG0066	3-isopropylmalate dehydratase activity
CS527_23505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CS527_23515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CS527_23520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CS527_23525	COG0440	acetolactate synthase activity
CS527_23530	COG0028	Belongs to the TPP enzyme family
CS527_23540	COG0622	Phosphoesterase
CS527_23550	COG5401	PFAM Sporulation and spore germination
CS527_23555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CS527_23560	COG1846	Transcriptional regulator
CS527_23570	COG0306	phosphate transporter
CS527_23575	COG1392	Phosphate transport regulator
CS527_23580	COG0768	penicillin binding
CS527_23590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CS527_23595	COG0431	NADPH-dependent FMN reductase
CS527_23600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_23605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS527_23610	COG1116	anion transmembrane transporter activity
CS527_23615	COG0475	glutathione-regulated potassium exporter activity
CS527_23620	COG0490	domain, Protein
CS527_23630	COG2197	response regulator
CS527_23635	COG0824	Thioesterase
CS527_23640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CS527_23645	COG1053	succinate dehydrogenase
CS527_23650	COG2009	succinate dehydrogenase
CS527_23655	COG1719	4-vinyl reductase, 4VR
CS527_23660	COG0527	aspartate kinase activity
CS527_23670	COG3118	belongs to the thioredoxin family
CS527_23680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CS527_23685	COG2086	electron transfer activity
CS527_23690	COG1024	Enoyl-CoA hydratase
CS527_23695	COG1309	transcriptional regulator
CS527_23700	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_23705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CS527_23715	COG3766	membrane
CS527_23720	COG1193	negative regulation of DNA recombination
CS527_23725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS527_23725	COG1796	DNA polymerase
CS527_23730	COG1286	toxin biosynthetic process
CS527_23735	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CS527_23740	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CS527_23745	COG0072	phenylalanine-tRNA ligase activity
CS527_23745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS527_23755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CS527_23765	COG1363	Peptidase, m42
CS527_23785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CS527_23790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CS527_23795	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CS527_23800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CS527_23810	COG1484	DNA-dependent DNA replication
CS527_23815	COG3611	Membrane attachment protein
CS527_23820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CS527_23830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CS527_23835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CS527_23840	COG0237	dephospho-CoA kinase activity
CS527_23845	COG1971	Probably functions as a manganese efflux pump
CS527_23850	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CS527_23855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS527_23855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CS527_23860	COG5002	protein histidine kinase activity
CS527_23865	COG0745	RESPONSE REGULATOR receiver
CS527_23875	COG0039	L-malate dehydrogenase activity
CS527_23880	COG0538	isocitrate dehydrogenase activity
CS527_23885	COG0372	Belongs to the citrate synthase family
CS527_23890	COG2707	UPF0756 membrane protein
CS527_23895	COG0628	permease
CS527_23900	COG3030	protein affecting phage T7 exclusion by the F plasmid
CS527_23910	COG0825	malonyl-CoA metabolic process
CS527_23915	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CS527_23920	COG2186	Transcriptional regulator
CS527_23925	COG0281	malic enzyme
CS527_23930	COG0587	DNA-directed DNA polymerase activity
CS527_23945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CS527_23955	COG4109	DRTGG domain
CS527_23965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CS527_23975	COG0165	Argininosuccinate lyase
CS527_23980	COG0137	argininosuccinate synthase activity
CS527_23995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CS527_24000	COG0827	DNA restriction-modification system
CS527_24005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CS527_24010	COG3874	Sporulation protein YtfJ
CS527_24020	COG1714	RDD family
CS527_24025	COG0616	signal peptide processing
CS527_24030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CS527_24035	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CS527_24045	COG0301	tRNA thio-modification
CS527_24050	COG1104	cysteine desulfurase activity
CS527_24055	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CS527_24060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CS527_24065	COG1309	transcriptional regulator
CS527_24070	COG1956	GAF domain-containing protein
CS527_24080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CS527_24085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CS527_24090	COG0454	-acetyltransferase
CS527_24095	COG0517	IMP dehydrogenase activity
CS527_24100	COG0123	including yeast histone deacetylase and acetoin utilization protein
CS527_24120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CS527_24120	COG1605	Chorismate mutase
CS527_24125	COG3118	belongs to the thioredoxin family
CS527_24130	COG4980	gas vesicle protein
CS527_24145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CS527_24155	COG1674	ftsk spoiiie
CS527_24160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CS527_24165	COG4848	Belongs to the UPF0354 family
CS527_24170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_24175	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CS527_24180	COG1363	Peptidase, m42
CS527_24185	COG5584	Small secreted protein
CS527_24190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CS527_24195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CS527_24205	COG0510	thiamine kinase activity
CS527_24210	COG1523	belongs to the glycosyl hydrolase 13 family
CS527_24220	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CS527_24230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CS527_24235	COG1349	DNA-binding transcription factor activity
CS527_24240	COG1187	pseudouridine synthase activity
CS527_24245	COG2244	polysaccharide biosynthetic process
CS527_24250	COG2081	HI0933 family
CS527_24260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CS527_24265	COG0495	leucyl-tRNA aminoacylation
CS527_24275	COG2610	gluconate transmembrane transporter activity
CS527_24280	COG2814	Major facilitator Superfamily
CS527_24295	COG1242	4 iron, 4 sulfur cluster binding
CS527_24300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CS527_24310	COG2267	carboxylic ester hydrolase activity
CS527_24315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CS527_24320	COG0671	phosphoesterase, PA-phosphatase related
CS527_24325	COG0438	transferase activity, transferring glycosyl groups
CS527_24330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CS527_24335	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CS527_24345	COG1506	peptidase
CS527_24350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CS527_24355	COG1116	anion transmembrane transporter activity
CS527_24360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CS527_24365	COG0494	nUDIX hydrolase
CS527_24375	COG4824	toxin secretion phage lysis holin
CS527_24380	COG0783	Belongs to the Dps family
CS527_24390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CS527_24395	COG0288	reversible hydration of carbon dioxide
CS527_24400	COG0523	cobalamin synthesis protein
CS527_24410	COG0254	rRNA binding
CS527_24415	COG1271	oxidase subunit
CS527_24420	COG1294	oxidase, subunit
CS527_24425	COG0716	FMN binding
CS527_24450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_24455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CS527_24460	COG4948	Mandelate Racemase Muconate Lactonizing
CS527_24465	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_24470	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CS527_24475	COG0596	Alpha beta hydrolase
CS527_24480	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CS527_24485	COG1169	isochorismate synthase
CS527_24490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CS527_24500	COG0058	SHG alpha-glucan phosphorylase activity
CS527_24505	COG0297	glycogen (starch) synthase activity
CS527_24510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CS527_24645	COG0318	PFAM AMP-dependent synthetase and ligase
CS527_24650	COG1285	pathogenesis
CS527_24670	COG0529	Catalyzes the synthesis of activated sulfate
CS527_24680	COG0306	phosphate transporter
CS527_24690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CS527_24695	COG0346	lactoylglutathione lyase activity
CS527_24700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CS527_24715	COG0166	Belongs to the GPI family
CS527_24725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CS527_24725	COG2111	Na H antiporter
CS527_24730	COG2111	Na H antiporter
CS527_24735	COG1006	Multisubunit Na H antiporter MnhC subunit
CS527_24740	COG0651	ATP synthesis coupled electron transport
CS527_24745	COG1863	multisubunit Na H antiporter MnhE subunit
CS527_24750	COG2212	antiporter activity
CS527_24755	COG1320	monovalent cation:proton antiporter activity
CS527_24760	COG1979	alcohol dehydrogenase
CS527_24765	COG2155	Conserved Protein
CS527_24770	COG1098	S1 RNA binding domain
CS527_24775	COG0436	Aminotransferase
CS527_24780	COG1522	sequence-specific DNA binding
CS527_24785	COG2267	carboxylic ester hydrolase activity
CS527_24790	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CS527_24795	COG2032	superoxide dismutase activity
CS527_24810	COG5018	Exonuclease
CS527_24815	COG2050	protein possibly involved in aromatic compounds catabolism
CS527_24825	COG1418	mRNA catabolic process
CS527_24835	COG2056	Na+-H+ antiporter family
CS527_24840	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CS527_24845	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CS527_24850	COG3584	3D domain protein
CS527_24860	COG1252	NADH dehydrogenase
CS527_24865	COG0492	ferredoxin-NADP+ reductase activity
CS527_24875	COG0316	Belongs to the HesB IscA family
CS527_24880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CS527_24890	COG4844	belongs to the
CS527_24895	COG1252	NADH dehydrogenase
CS527_24900	COG4837	Protein of unknown function (DUF1462)
CS527_24905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CS527_24910	COG0083	homoserine kinase activity
CS527_24915	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CS527_24920	COG0460	homoserine dehydrogenase
CS527_24925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CS527_24930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CS527_24935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CS527_24940	COG0647	UMP catabolic process
CS527_24945	COG2445	Protein of unknown function DUF86
CS527_24955	COG4470	Protein conserved in bacteria
CS527_24965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CS527_24970	COG0739	heme binding
CS527_24985	COG3377	Domain of unknown function (DUF1805)
CS527_24990	COG1801	Protein of unknown function DUF72
CS527_24995	COG0719	Fe-S assembly protein
CS527_25000	COG0822	iron-sulfur transferase activity
CS527_25005	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CS527_25010	COG0719	Fe-S assembly protein
CS527_25015	COG0396	ATPase activity
CS527_25020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CS527_25025	COG1464	Belongs to the NlpA lipoprotein family
CS527_25030	COG2011	ABC-type metal ion transport system permease component
CS527_25035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CS527_25040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CS527_25045	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CS527_25055	COG0509	glycine decarboxylation via glycine cleavage system
CS527_25060	COG1393	Belongs to the ArsC family
CS527_25065	COG1960	acyl-CoA dehydrogenase activity
CS527_25070	COG0183	Belongs to the thiolase family
CS527_25075	COG1024	Enoyl-CoA hydratase
CS527_25075	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS527_25100	COG1120	ATPase activity
CS527_25105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_25110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CS527_25115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CS527_25125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CS527_25130	COG1309	transcriptional regulator
CS527_25140	COG1028	Short-chain dehydrogenase reductase Sdr
CS527_25145	COG0477	Major facilitator Superfamily
CS527_25155	COG3850	Histidine kinase
CS527_25155	COG5002	protein histidine kinase activity
CS527_25160	COG0745	RESPONSE REGULATOR receiver
CS527_25165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CS527_25170	COG0671	phosphoesterase, PA-phosphatase related
CS527_25180	COG1846	Transcriptional regulator
CS527_25185	COG0778	Nitroreductase
CS527_25190	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CS527_25195	COG0314	molybdopterin synthase activity
CS527_25200	COG1763	Mo-molybdopterin cofactor biosynthetic process
CS527_25205	COG0303	'Molybdopterin
CS527_25210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CS527_25215	COG0746	molybdenum cofactor guanylyltransferase activity
CS527_25225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CS527_25230	COG5609	conserved protein (DUF2294)
CS527_25235	COG3383	formate dehydrogenase (NAD+) activity
CS527_25240	COG2427	Protein of unknown function (DUF1641)
CS527_25245	COG0725	ABC transporter, periplasmic molybdate-binding protein
CS527_25250	COG4149	molybdate abc transporter
CS527_25260	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CS527_25265	COG0557	exoribonuclease II activity
CS527_25270	COG1647	Serine aminopeptidase, S33
CS527_25275	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CS527_25285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CS527_25315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CS527_25335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CS527_25345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CS527_25350	COG1660	Displays ATPase and GTPase activities
CS527_25355	COG1051	belongs to the nudix hydrolase family
CS527_25360	COG0492	ferredoxin-NADP+ reductase activity
CS527_25365	COG0457	Tetratricopeptide repeat
CS527_25370	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CS527_25370	COG0140	phosphoribosyl-ATP diphosphatase activity
CS527_25375	COG0107	imidazoleglycerol-phosphate synthase activity
CS527_25380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CS527_25385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CS527_25390	COG0131	Imidazoleglycerol-phosphate dehydratase
CS527_25395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CS527_25400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CS527_25405	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CS527_25410	COG0110	maltose O-acetyltransferase activity
CS527_25415	COG0546	phosphoglycolate phosphatase activity
CS527_25420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CS527_25425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CS527_25430	COG1950	PFAM Membrane protein of
CS527_25440	COG3595	metallopeptidase activity
CS527_25450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CS527_25455	COG0556	nucleotide-excision repair
CS527_25460	COG2204	response regulator
CS527_25465	COG1012	belongs to the aldehyde dehydrogenase family
CS527_25470	COG0506	proline dehydrogenase activity
CS527_25475	COG4897	Protein conserved in bacteria
CS527_25480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS527_25485	COG0793	Belongs to the peptidase S41A family
CS527_25485	COG3409	Peptidoglycan-binding domain 1 protein
CS527_25490	COG0739	heme binding
CS527_25495	COG2177	Part of the ABC transporter FtsEX involved in
CS527_25500	COG2884	Cell division ATP-binding protein ftsE
CS527_25505	COG0655	NAD(P)H dehydrogenase (quinone) activity
CS527_25515	COG0805	protein transport
CS527_25520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CS527_25525	COG3540	Alkaline phosphatase
CS527_25535	COG0653	protein targeting
CS527_25540	COG0456	acetyltransferase
CS527_25545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CS527_25555	COG1516	flagellar protein fliS
CS527_25560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CS527_25570	COG1113	amino acid transport
CS527_25585	COG1454	alcohol dehydrogenase
CS527_25590	COG1510	regulation of RNA biosynthetic process
CS527_25595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CS527_25600	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CS527_25605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CS527_25610	COG4786	Flagellar basal body rod
CS527_25610	COG1256	bacterial-type flagellum assembly
CS527_25630	COG1040	competence protein
CS527_25635	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CS527_25640	COG1307	EDD domain protein, DegV family
CS527_25645	COG1728	Protein conserved in bacteria
CS527_25655	COG2197	response regulator
CS527_25660	COG4585	Histidine kinase
CS527_25665	COG1739	Uncharacterized protein family UPF0029
CS527_25670	COG1316	TRANSCRIPTIONal
CS527_25675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CS527_25680	COG1585	Membrane protein implicated in regulation of membrane protease activity
CS527_25685	COG2268	Band 7 protein
CS527_25690	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CS527_25700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CS527_25710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CS527_25715	COG0791	NLP P60 protein
CS527_25715	COG1388	LysM domain
CS527_25720	COG0629	single-stranded DNA binding
CS527_25745	COG4786	Flagellar basal body rod
CS527_25750	COG4786	Flagellar basal body rod
CS527_25755	COG1077	Cell shape determining protein MreB Mrl
CS527_25760	COG1609	Transcriptional regulator
CS527_25765	COG0739	heme binding
CS527_25770	COG2385	sporulation resulting in formation of a cellular spore
CS527_25785	COG4836	Membrane
CS527_25790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CS527_25795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CS527_25800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CS527_25805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CS527_25810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CS527_25815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CS527_25820	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CS527_25825	COG0356	it plays a direct role in the translocation of protons across the membrane
CS527_25840	COG1404	Belongs to the peptidase S8 family
CS527_25845	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CS527_25850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CS527_25865	COG0698	ribose 5-phosphate isomerase
CS527_25875	COG1971	Probably functions as a manganese efflux pump
CS527_25880	COG0009	L-threonylcarbamoyladenylate synthase
CS527_25900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CS527_25915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CS527_25925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CS527_25930	COG0191	fructose-bisphosphate aldolase activity
CS527_25935	COG2204	response regulator
CS527_25940	COG4821	SIS domain
CS527_25945	COG0504	CTP synthase activity
CS527_25955	COG1703	isobutyryl-CoA mutase activity
CS527_25955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_25955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CS527_25965	COG1960	acyl-CoA dehydrogenase activity
CS527_25970	COG1960	acyl-CoA dehydrogenase activity
CS527_25975	COG1250	3-hydroxyacyl-CoA dehydrogenase
CS527_25980	COG0183	Belongs to the thiolase family
CS527_25985	COG2181	nitrate reductase activity
CS527_25985	COG0247	lactate metabolic process
CS527_25990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CS527_26005	COG4506	Protein conserved in bacteria
CS527_26010	COG0010	Belongs to the arginase family
CS527_26015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CS527_26020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CS527_26030	COG1994	Peptidase M50
CS527_26035	COG1942	4-Oxalocrotonate Tautomerase
CS527_26040	COG3465	dGTPase activity
CS527_26045	COG1078	dGTPase activity
CS527_26050	COG4844	belongs to the
CS527_26060	COG0095	Lipoate-protein ligase
CS527_26065	COG0280	phosphate acetyltransferase
CS527_26075	COG3773	Cell wall hydrolase
CS527_26085	COG2363	Small membrane protein
CS527_26095	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CS527_26105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CS527_26110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CS527_26115	COG2508	Transcriptional regulator
CS527_26115	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CS527_26120	COG0686	Belongs to the AlaDH PNT family
CS527_26130	COG0351	phosphomethylpyrimidine kinase
CS527_26135	COG0561	phosphatase activity
CS527_26140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CS527_26145	COG1263	PTS System
CS527_26145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CS527_26145	COG2190	(PTS) system
CS527_26155	COG0438	transferase activity, transferring glycosyl groups
CS527_26170	COG2076	Multidrug Resistance protein
CS527_26180	COG0728	peptidoglycan biosynthetic process
CS527_26195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CS527_26200	COG4988	ABC transporter
CS527_26205	COG1294	oxidase, subunit
CS527_26210	COG1271	oxidase subunit
CS527_26215	COG3610	response to peptide
CS527_26220	COG2966	Psort location CytoplasmicMembrane, score
CS527_26225	COG1609	Transcriptional regulator
CS527_26235	COG2814	Major facilitator Superfamily
CS527_26250	COG1966	Carbon starvation protein
CS527_26255	COG0753	catalase activity
CS527_26270	COG0471	metal ion transport
CS527_26275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CS527_26285	COG0745	RESPONSE REGULATOR receiver
CS527_26290	COG5002	protein histidine kinase activity
CS527_26305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CS527_26310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CS527_26320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CS527_26325	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CS527_26330	COG4853	Protein conserved in bacteria
CS527_26340	COG5002	protein histidine kinase activity
CS527_26345	COG0745	RESPONSE REGULATOR receiver
CS527_26370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CS527_26375	COG0305	Participates in initiation and elongation during chromosome replication
CS527_26385	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CS527_26395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CS527_26410	COG0012	GTP binding
CS527_26415	COG4481	Protein conserved in bacteria
CS527_26420	COG0668	transmembrane transport
CS527_26425	COG3949	Membrane
CS527_26435	COG1475	DNA binding
CS527_26440	COG1192	Involved in chromosome partitioning
CS527_26445	COG1475	DNA binding
CS527_26455	COG0445	tRNA wobble uridine modification
CS527_26460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CS527_26465	COG1847	R3H domain protein
CS527_26470	COG0706	membrane insertase activity
CS527_26475	COG0594	ribonuclease P activity
CS527_26480	COG0230	Belongs to the bacterial ribosomal protein bL34 family