locus-tag class description QF06_00005 ENOG4107E6A Cytochrome p-450 QF06_00015 ENOG4107QTZ amino acid QF06_00020 ENOG4107VXM glycerophosphoryl diester phosphodiesterase QF06_00035 ENOG410645S MarR family Transcriptional regulator QF06_00040 ENOG4105DCM major facilitator superfamily QF06_00055 ENOG410631K Membrane QF06_00060 ENOG4106AXJ AraC family transcriptional regulator QF06_00065 ENOG41065RQ ADP-ribosylation crystallin J1 QF06_00070 ENOG4106BHF QF06_00075 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR QF06_00080 ENOG4108TCS Glutamyl endopeptidase QF06_00090 ENOG4108WC5 Alpha Beta Hydrolase Fold protein QF06_00095 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase QF06_00100 ENOG4107ZTW SNARE associated Golgi QF06_00120 ENOG4105C72 UPF0176 protein QF06_00130 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane QF06_00135 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) QF06_00140 ENOG4108X79 transcriptional regulator QF06_00145 ENOG4105CM2 brancheD-chain amino acid aminotransferase QF06_00150 ENOG4108IQI permease QF06_00155 ENOG4108J5H Homocysteine s-methyltransferase QF06_00170 ENOG4105CSV Glutaminase QF06_00185 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase QF06_00190 ENOG4105C26 Dehydrogenase QF06_00195 ENOG4105DJB Major Facilitator Superfamily QF06_00200 ENOG4105EQX glucarate dehydratase QF06_00205 ENOG41073TP transcriptional regulator QF06_00210 ENOG4105CTX dehydratase QF06_00225 ENOG4106UX7 integral membrane protein QF06_00230 ENOG4105DPZ Two component transcriptional regulator (Winged helix family QF06_00260 ENOG4105MUA Resistance protein QF06_00265 ENOG4105DGI Alkaline phosphatase QF06_00270 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) QF06_00275 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) QF06_00280 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) QF06_00285 ENOG4107EPV Aminotransferase class V QF06_00290 ENOG4105C0R drug resistance transporter emrb qaca subfamily QF06_00295 ENOG4105J7D transcriptional regulator QF06_00300 ENOG4107RB3 L-asparaginase QF06_00305 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold QF06_00315 ENOG41060AI SEC-C motif QF06_00325 ENOG4107Y7X LytTR QF06_00330 ENOG4108IUW ABC transporter QF06_00335 ENOG4108SDH ABC, transporter QF06_00340 ENOG4107SET aldo keto reductase QF06_00370 ENOG4105H9W Short-chain dehydrogenase reductase Sdr QF06_00380 ENOG4105DSE periplasmic solute binding protein QF06_00385 ENOG4105DIK (ABC) transporter QF06_00395 ENOG4105DEN Luciferase family QF06_00400 ENOG4108N0M stress protein QF06_00405 ENOG4106FN3 tellurium resistance protein QF06_00410 ENOG4106FN3 tellurium resistance protein QF06_00415 ENOG4107TS3 membrane protein, TerC QF06_00420 ENOG4108TTB tellurium resistance protein QF06_00430 ENOG41079KZ Major Facilitator Superfamily QF06_00435 ENOG4107XZQ multidrug resistance protein QF06_00440 ENOG4108A65 Transcriptional regulator QF06_00445 ENOG4108IJ7 Glycine betaine QF06_00450 ENOG4107SQ8 Glycine betaine QF06_00480 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) QF06_00515 ENOG4105EIG urea carboxylase-associated protein 1 QF06_00520 ENOG4107RA1 nh(3)-dependent nad( ) synthetase QF06_00525 ENOG4105I1F Resistance protein QF06_00530 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) QF06_00535 ENOG41089UC methyltransferase, type 11 QF06_00540 ENOG4105C5Q Transcriptional regulator QF06_00545 ENOG4105I82 acetyl xylan esterase QF06_00550 ENOG410756H nucleotidyltransferase QF06_00560 ENOG4105C26 Dehydrogenase QF06_00565 ENOG4105CK7 Sodium proline symporter QF06_00570 ENOG4107YHD transcriptional regulator QF06_00580 ENOG4108PJD permease QF06_00585 ENOG4105U6C Alpha beta hydrolase fold protein QF06_00595 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) QF06_00600 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit QF06_00605 ENOG4108IFG nitrite reductase, (NAD(P)H) QF06_00610 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) QF06_00630 ENOG4105S7A ErfK ybiS ycfS ynhG family protein QF06_00635 ENOG4105CKI cobalamin synthesis protein QF06_00640 ENOG4105E5Q amino acid AbC transporter QF06_00645 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein QF06_00655 ENOG4105HHM rdd domain containing protein QF06_00665 ENOG4105CS2 ec 3.2.1.21 QF06_00680 ENOG4105C8Q Methyl-accepting chemotaxis QF06_00685 ENOG41080HJ 6-phospho 3-hexuloisomerase QF06_00690 ENOG4108VA3 3-hexulose-6-phosphate synthase QF06_00695 ENOG4105KVH Transcriptional regulator QF06_00700 ENOG4105CEY Amp-dependent synthetase and ligase QF06_00730 ENOG4105SX7 Transporter QF06_00740 ENOG4105W8Z 4'-phosphopantetheinyl transferase QF06_00750 ENOG4105CDA abc transporter atp-binding protein QF06_00755 ENOG4105DRP amino acid AbC transporter QF06_00765 ENOG4106P55 Transcriptional regulator QF06_00770 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase QF06_00775 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) QF06_00780 ENOG41069ZX QF06_00785 ENOG41069ZX QF06_00795 ENOG4105DUX Transporter QF06_00810 ENOG4105E1K spore germination protein QF06_00830 ENOG4107WD8 ABC transporter, permease QF06_00835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family QF06_00840 ENOG4105BZU Histidine kinase QF06_00865 ENOG4105CFH Aspartokinase QF06_00870 ENOG4105DHS permease protein QF06_00875 ENOG4105CM4 permease protein QF06_00880 ENOG4108IPW abc transporter atp-binding protein QF06_00895 ENOG4105R8C Transcriptional regulator QF06_00900 ENOG4108DBC nitroreductase QF06_00905 ENOG41067V3 Antibiotic biosynthesis monooxygenase QF06_00910 ENOG4105YVS arsR family transcriptional regulator QF06_00920 ENOG4108JPW Aminotransferase QF06_00925 ENOG4105C26 Dehydrogenase QF06_00935 ENOG4105H9W Short-chain dehydrogenase reductase Sdr QF06_00940 ENOG4105KTB nuclear export factor GLE1 QF06_00945 ENOG4108T5E Copper resistance protein QF06_00950 ENOG4108ZYE Transcriptional regulator QF06_00975 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) QF06_00980 ENOG4108ZX0 Signal peptidase I QF06_01000 ENOG4105E7W lamb ycsf family protein QF06_01005 ENOG4105C5A transporter QF06_01010 ENOG4105CFM UPF0317 protein QF06_01015 ENOG4105P4J Allophanate hydrolase, subunit 1 QF06_01025 ENOG4107258 Transcriptional regulator QF06_01030 ENOG4105XJB lipolytic protein G-D-S-L family QF06_01040 ENOG41061CK Antibiotic biosynthesis monooxygenase QF06_01045 ENOG4107RVG penicillin-binding protein QF06_01050 ENOG4107QM2 Aldo Keto reductase QF06_01055 ENOG4105ETD TRANSCRIPTIONal QF06_01065 ENOG4105HMZ Methyltransferase QF06_01070 ENOG4105CYX Short-chain dehydrogenase reductase Sdr QF06_01085 ENOG410606W general stress protein QF06_01095 ENOG4105VCH membrane QF06_01105 ENOG4105C9U ATP-dependent DNA helicase RecQ QF06_01120 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) QF06_01125 ENOG4107R8N Glycosyl transferase, family 2 QF06_01135 ENOG4105C0X amino acid QF06_01155 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) QF06_01165 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) QF06_01170 ENOG4105EU9 QF06_01175 ENOG4105QVS general stress protein QF06_01180 ENOG41082W1 Cupin 2, conserved barrel domain protein QF06_01195 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit QF06_01200 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism QF06_01205 ENOG4108MRH transcriptional regulatory protein QF06_01210 ENOG4107QJT sodium dicarboxylate symporter QF06_01215 ENOG4106F5Q Membrane QF06_01220 ENOG4105CJ1 ABC, transporter QF06_01235 ENOG4105FDT acyl-CoA dehydrogenase QF06_01245 ENOG4105SZ6 Thioredoxin QF06_01250 ENOG4105CPF Cell wall formation (By similarity) QF06_01255 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) QF06_01260 ENOG4105C1J atp-dependent rna helicase QF06_01265 ENOG410905X membrane-flanked domain protein QF06_01270 ENOG4105CKV Membrane QF06_01280 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) QF06_01285 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein QF06_01290 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) QF06_01300 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) QF06_01305 ENOG4107MMM Anti-sigma-factor antagonist QF06_01310 ENOG4105FUA antagonist QF06_01315 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase QF06_01320 ENOG4107SGM protein serine threonine phosphatase QF06_01325 ENOG4105WN5 stage II sporulation protein QF06_01330 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) QF06_01340 ENOG41064BQ Phosphatase QF06_01390 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) QF06_01415 ENOG4106ANW SMI1_KNR4 QF06_01425 ENOG4106BHF QF06_01435 ENOG4105VZ8 Transcriptional regulator QF06_01445 ENOG4105ECK Fatty Acid Desaturase QF06_01450 ENOG4105VEQ Cold shock protein QF06_01455 ENOG4108VJ1 Transcriptional regulator (CarD family QF06_01465 ENOG4108MCI Transcriptional regulator, ARAC family QF06_01470 ENOG4108UZ3 Transporter QF06_01475 ENOG41086D8 Transcriptional regulator QF06_01480 ENOG4107U9B transcriptional regulator QF06_01485 ENOG4105DXI Major Facilitator superfamily QF06_01495 ENOG4105CZ9 Domain of unknown function (DU1801) QF06_01500 ENOG4105GIG QF06_01505 ENOG4105KRI phosphocarrier protein (HPr QF06_01510 ENOG4105ST3 Transcriptional regulator QF06_01515 ENOG4105T38 integral membrane protein QF06_01520 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family QF06_01525 ENOG4108ZMQ domain protein QF06_01530 ENOG4105MJ9 esterase QF06_01535 ENOG4107Z6X Transcriptional regulator QF06_01545 ENOG4105KVH Transcriptional regulator QF06_01550 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein QF06_01555 ENOG4105EQ0 Major Facilitator superfamily QF06_01560 ENOG4108JGH Tetr family transcriptional regulator QF06_01565 ENOG41082YX Transcriptional regulator, arsr family QF06_01570 ENOG4107R5R arsenical pump membrane protein QF06_01575 ENOG4105Z7P Acetyltransferase (GNAT) family QF06_01580 ENOG4107Y9U Membrane QF06_01590 ENOG4108SQ9 flavin reductase domain protein, FMN-binding QF06_01595 ENOG4108ZHR arsR family transcriptional regulator QF06_01600 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) QF06_01610 ENOG4105ENE Histidine kinase QF06_01615 ENOG4108VB1 regulatoR QF06_01620 ENOG4105EYF MMPL domain protein QF06_01625 ENOG4108WC5 Alpha Beta Hydrolase Fold protein QF06_01630 ENOG4108UQV Membrane QF06_01635 ENOG4108Z5V transcriptional regulator, merr family QF06_01640 ENOG41076HS cation diffusion facilitator family transporter QF06_01645 ENOG4108TVJ Nitroreductase QF06_01650 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase QF06_01655 ENOG4108VGI doxx family QF06_01660 ENOG4105XXY Thioredoxin QF06_01685 ENOG410900G Protein of unknown function (DUF421) QF06_01690 ENOG4108QY0 Membrane QF06_01710 ENOG4105PF9 Transcriptional regulator QF06_01720 ENOG4105WQG acetyltransferase QF06_01730 ENOG4105C85 amino acid QF06_01740 ENOG41062A4 Transcriptional regulator QF06_01745 ENOG4105EYF MMPL domain protein QF06_01750 ENOG4108TVJ Nitroreductase QF06_01755 ENOG4105FS7 Transcriptional regulator QF06_01760 ENOG4105C2C drug resistance transporter, Bcr CflA QF06_01770 ENOG4105DRR Transcriptional regulator, GntR family QF06_01775 ENOG4105VRS hydrolase family 18 QF06_01790 ENOG4105G6Z alkaline phosphatase QF06_01795 ENOG4108ZMX Domain of unknown function (DU1801) QF06_01805 ENOG4108YM7 Gcn5-related n-acetyltransferase QF06_01810 ENOG4107TVP HD domain protein QF06_01815 ENOG41090UD (LipO)protein QF06_01820 ENOG4105F27 Major Facilitator QF06_01825 ENOG4105VZJ PTS System QF06_01830 ENOG4105VCP PTS System QF06_01835 ENOG4105CK1 PTS System QF06_01840 ENOG4105CS2 ec 3.2.1.21 QF06_01845 ENOG4108TZY GntR Family Transcriptional Regulator QF06_01850 ENOG4105EVU fructokinase QF06_01855 ENOG4105DG6 mannose-6-phosphate isomerase QF06_01860 ENOG4105D3P Mannan endo-1,4-beta-mannosidase QF06_01905 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) QF06_01910 ENOG4105K8N protein family UPF0079, ATPase QF06_01915 ENOG41072GX Peptidase M22 Glycoprotease QF06_01920 ENOG410801F ribosomal-protein-alanine acetyltransferase QF06_01925 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) QF06_01930 ENOG4105C5H ABC transporter QF06_01935 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) QF06_01940 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) QF06_01945 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) QF06_01950 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) QF06_01960 ENOG4108TYN CAAX amino terminal protease family protein QF06_01965 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) QF06_01970 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) QF06_01980 ENOG4105PGZ NB-ARC domain QF06_01985 ENOG4105CPQ Dehydrogenase QF06_01990 ENOG4105CT4 transporter QF06_02000 ENOG41087YS Phage shock protein A QF06_02005 ENOG4105DQX Zinc finger domain QF06_02010 ENOG4108WV1 Pfam:DUF477 QF06_02020 ENOG4108ZMR Ion transport 2 domain-containing protein QF06_02025 ENOG4107QNK )-transporter QF06_02055 ENOG4107YUH hydrolase QF06_02065 ENOG4107STQ Multicopper oxidase QF06_02070 ENOG4105C85 amino acid QF06_02080 ENOG4105C7R Atpase associated with various cellular activities aaa_3 QF06_02110 ENOG4105C7N Xanthine uracil vitamin C permease QF06_02130 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) QF06_02135 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit QF06_02140 ENOG4105C83 adenylosuccinate lyase QF06_02145 ENOG4105C8V SAICAR synthetase QF06_02150 ENOG4105VR9 phosphoribosylformylglycinamidine synthase QF06_02155 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I QF06_02160 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii QF06_02170 ENOG4105CXB phosphoribosylaminoimidazole synthetase QF06_02175 ENOG4108V3E phosphoribosylglycinamide formyltransferase QF06_02180 ENOG4105DC1 bifunctional purine biosynthesis protein purh QF06_02185 ENOG4105C12 Phosphoribosylglycinamide synthetase QF06_02195 ENOG4105DVH amino acid QF06_02210 ENOG4108R5T secreted protein QF06_02215 ENOG4105KGF protein, YerC YecD QF06_02220 ENOG4105CBC glutamate synthase QF06_02225 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) QF06_02230 ENOG4105C4R Atp-dependent dna helicase QF06_02235 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) QF06_02245 ENOG4105CRN Aminoglycoside phosphotransferase QF06_02250 ENOG4105KT7 mgtC SapB transporter QF06_02255 ENOG4105CK7 Sodium proline symporter QF06_02260 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) QF06_02265 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) QF06_02270 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) QF06_02275 ENOG4108IG5 Transcriptional regulator QF06_02285 ENOG4105CBD Diacylglycerol kinase QF06_02290 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) QF06_02325 ENOG4105CDY transcriptional regulatory protein QF06_02335 ENOG4105M4P Tetr family transcriptional regulator QF06_02340 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein QF06_02345 ENOG4107S9F NmrA family QF06_02360 ENOG4105WEF catalase QF06_02365 ENOG4105M18 -acetyltransferase QF06_02380 ENOG4105C2F Histidine kinase QF06_02385 ENOG4105EQD regulatoR QF06_02390 ENOG410769Z extracellular solute-binding protein family 1 QF06_02395 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component QF06_02400 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component QF06_02405 ENOG4105F5H Glycosyl Hydrolase Family 88 QF06_02410 ENOG41075H3 AraC family transcriptional regulator QF06_02415 ENOG4107TDE lipolytic protein G-D-S-L family QF06_02430 ENOG4105CX8 fg-gap repeat protein QF06_02435 ENOG4105CX8 fg-gap repeat protein QF06_02440 ENOG4107TDE lipolytic protein G-D-S-L family QF06_02450 ENOG4105EKC QF06_02455 ENOG4105E0S extracellular solute-binding protein family 1 QF06_02465 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component QF06_02470 ENOG4105F8D glycoside hydrolase family 4 QF06_02475 ENOG4105H67 Protein of unknown function (DUF421) QF06_02480 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) QF06_02485 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily QF06_02500 ENOG4106I4J membrane QF06_02505 ENOG4108PCN EamA-like transporter family QF06_02510 ENOG41082F9 transcriptional regulator QF06_02515 ENOG41061H0 Monooxygenase QF06_02525 ENOG4108R1P QF06_02530 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) QF06_02535 ENOG4105E0M Sulfatase QF06_02540 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase QF06_02550 ENOG41090R9 glycosyltransferase QF06_02555 ENOG4107R51 Glycosyl transferase, family 2 QF06_02560 ENOG41090R9 glycosyltransferase QF06_02565 ENOG4105EU0 Major facilitator Superfamily QF06_02575 ENOG4105CUB amino acid QF06_02580 ENOG4105C26 Dehydrogenase QF06_02585 ENOG4105FKZ Methyl-accepting chemotaxis QF06_02590 ENOG4105C5H ABC transporter QF06_02600 ENOG4107SWG transcriptional regulator MERR family QF06_02605 ENOG4105DXB Major Facilitator superfamily QF06_02625 ENOG4105C5H ABC transporter QF06_02630 ENOG4105FDU atp-dependent rna helicase QF06_02640 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein QF06_02645 ENOG4105E0A ABC, transporter QF06_02650 ENOG4108U1V ABC transporter, permease QF06_02655 ENOG4105DQ5 transport system permease protein QF06_02660 ENOG4108HUF Transporter QF06_02675 ENOG4108J20 pectate lyase QF06_02680 ENOG4107QPK )-transporter QF06_02690 ENOG4108MRH transcriptional regulatory protein QF06_02715 ENOG410855V Acylphosphatase QF06_02720 ENOG4108RPX mosc domain containing protein QF06_02730 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) QF06_02755 ENOG4105GEU Spore germination protein QF06_02765 ENOG4108Q5U germination protein, ger(x)c family QF06_02770 ENOG4105E1K spore germination protein QF06_02775 ENOG4105C5Y PTS System QF06_02780 ENOG4105CG3 alpha amylase, catalytic region QF06_02785 ENOG4107414 GntR family transcriptional regulator QF06_02790 ENOG4108RCM Nitroreductase QF06_02795 ENOG4105CGH 5'-nucleotidase QF06_02800 ENOG4107RKG DJ-1/PfpI family QF06_02815 ENOG4105KJF protein tyrosine phosphatase QF06_02825 ENOG4107U9T Pfam:Ribonuclease_BN QF06_02830 ENOG4108ISG Major Facilitator QF06_02835 ENOG4105UPD Calcium Proton QF06_02845 ENOG4105D8X mechanosensitive ion channel QF06_02865 ENOG4106KE4 Dehydrogenase QF06_02870 ENOG4105D7N magnesium and cobalt transport protein CorA QF06_02880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) QF06_02900 ENOG4107RUY (E1 component), alpha subunit QF06_02910 ENOG4107QKR Dehydrogenase QF06_02920 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family QF06_02925 ENOG41069DP small acid-soluble spore protein QF06_02930 ENOG4105KK4 UPF0060 membrane protein QF06_02960 ENOG4105F8D glycoside hydrolase family 4 QF06_02965 ENOG4108Q3X Transcriptional regulator QF06_02970 ENOG4105CI1 PTS System QF06_02980 ENOG4105BZ1 (ABC) transporter QF06_02985 ENOG4105BZ1 (ABC) transporter QF06_02995 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase QF06_03000 ENOG4105BZU Histidine kinase QF06_03005 ENOG4105WH1 Two component transcriptional regulator luxr family QF06_03010 ENOG4105CJ1 ABC, transporter QF06_03015 ENOG41090VJ ABC-2 type transporter QF06_03020 ENOG4108KYE ABC-2 type transporter QF06_03025 ENOG4105U3E Transcriptional regulator QF06_03030 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold QF06_03035 ENOG4105H93 Acyltransferase family QF06_03040 ENOG4108YYS metal-dependent hydrolase (By similarity) QF06_03045 ENOG4105C0R drug resistance transporter emrb qaca subfamily QF06_03050 ENOG410834F Transcriptional regulator QF06_03060 ENOG4108MES Periplasmic binding protein QF06_03065 ENOG4105DQ5 transport system permease protein QF06_03070 ENOG4108IHU transport system permease protein QF06_03075 ENOG4105JAB phenazine biosynthesis protein, phzf family QF06_03080 ENOG4107Y03 Nitroreductase QF06_03090 ENOG4105ECP epimerase QF06_03105 ENOG4105F27 Major Facilitator QF06_03125 ENOG4106AKJ QF06_03130 ENOG4105D74 hydrolase QF06_03135 ENOG4105CKK Glycosyl transferase, family 2 QF06_03140 ENOG4105EJV Membrane QF06_03145 ENOG41067AE Membrane-bound metal-dependent hydrolase QF06_03150 ENOG4105CEN a g-specific adenine glycosylase QF06_03155 ENOG4106BXE QF06_03160 ENOG4105CAN Short-chain dehydrogenase reductase Sdr QF06_03175 ENOG4105EVI UPF0374 protein QF06_03180 ENOG4105BZ1 (ABC) transporter QF06_03185 ENOG4107NBY Membrane QF06_03195 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen QF06_03200 ENOG4105G5W regulator Fur family QF06_03310 ENOG4108N23 SpoOM-related protein QF06_03325 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) QF06_03345 ENOG4105E2Y ABC, transporter QF06_03350 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein QF06_03355 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component QF06_03360 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) QF06_03370 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) QF06_03375 ENOG4107D63 QF06_03380 ENOG4105VZ8 Transcriptional regulator QF06_03395 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) QF06_03405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) QF06_03425 ENOG4105CYN Serine protein kinase QF06_03430 ENOG4106AKX UPF0229 protein QF06_03435 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes QF06_03440 ENOG4105CW7 secretion protein, HlyD family QF06_03445 ENOG4105C0R drug resistance transporter emrb qaca subfamily QF06_03450 ENOG4105CS1 NAD(P)H quinone oxidoreductase QF06_03465 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family QF06_03470 ENOG4105CZV ABC transporter QF06_03475 ENOG4105CJ1 ABC, transporter QF06_03480 ENOG4108TU7 Inherit from COG: (ABC) transporter QF06_03485 ENOG4105VEQ Cold shock protein QF06_03495 ENOG4105BZU Histidine kinase QF06_03545 ENOG4108YBP pseudouridine synthase QF06_03555 ENOG41080XP Cbs domain QF06_03560 ENOG4107YBY Hydrolase QF06_03565 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase QF06_03570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) QF06_03575 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator QF06_03585 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) QF06_03590 ENOG4105C6V Glycerol-3-phosphate dehydrogenase QF06_03600 ENOG4105BZU Histidine kinase QF06_03605 ENOG4105WH1 Two component transcriptional regulator luxr family QF06_03640 ENOG4105ED1 spovr family QF06_03645 ENOG4105G6Z alkaline phosphatase QF06_03660 ENOG4105BZN citrate synthase QF06_03665 ENOG4105CYX Short-chain dehydrogenase reductase Sdr QF06_03670 ENOG4105CUB amino acid QF06_03675 ENOG4105C8J )-transporter QF06_03680 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family QF06_03695 ENOG4105J37 QF06_03700 ENOG4108AEY RNA polymerase sigma factor QF06_03705 ENOG4108FN7 Aldo keto reductase QF06_03710 ENOG4105F6E Acyl-transferase QF06_03715 ENOG4105C37 (CBS) domain QF06_03725 ENOG4105CHM Aminotransferase QF06_03730 ENOG4105C37 (CBS) domain QF06_03740 ENOG4105WMR Protein CrcB homolog QF06_03745 ENOG4108QXE glycerophosphoryl diester phosphodiesterase QF06_03750 ENOG4105D64 Mechanosensitive ion channel QF06_03755 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) QF06_03760 ENOG4107VMI polysaccharide deacetylase QF06_03765 ENOG4105F0I Aminotransferase QF06_03780 ENOG4105BZ1 (ABC) transporter QF06_03785 ENOG4105BZ1 (ABC) transporter QF06_03805 ENOG410839P QF06_03815 ENOG4106MP8 UPF0754 membrane protein QF06_03820 ENOG4105WZB UPF0342 protein QF06_03825 ENOG4105F1N DNA alkylation repair QF06_03835 ENOG4105D4P Coproporphyrinogen iii oxidase QF06_03840 ENOG4107S91 Sodium hydrogen exchanger QF06_03845 ENOG4105NCW Trka-c domain protein QF06_03855 ENOG4105CGU Enoyl-CoA hydratase QF06_03865 ENOG4108IUX (ABC) transporter QF06_03870 ENOG4105RHA ABC transporter, permease QF06_03875 ENOG4107VRP DNA repair exonuclease QF06_03880 ENOG4106D4I domain protein QF06_03885 ENOG4105EQI Metal Dependent Phosphohydrolase QF06_03895 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) QF06_03935 ENOG4105NBU tryptophan transport protein QF06_03940 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) QF06_03945 ENOG4105K59 histidine triad (HIT) protein QF06_03980 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation QF06_03985 ENOG4105BZ4 penicillin-binding protein QF06_03990 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) QF06_03995 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) QF06_04000 ENOG4105C1Q protoporphyrinogen oxidase QF06_04010 ENOG4105ECB domain protein QF06_04020 ENOG41090T1 Membrane QF06_04030 ENOG4105DER m42 family QF06_04045 ENOG4108RQ5 Beta-lactamase domain-containing protein QF06_04050 ENOG4105DF9 Lipoate-protein, ligase QF06_04060 ENOG4105CEY Amp-dependent synthetase and ligase QF06_04070 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 QF06_04080 ENOG4105KD7 acetyltransferase QF06_04090 ENOG4108HUF Transporter QF06_04095 ENOG4107TB6 phosphoglycerate mutase QF06_04105 ENOG4107F3J Amp-dependent synthetase and ligase QF06_04110 ENOG4107ZYJ bioY protein QF06_04115 ENOG4106YBV Methyl-accepting chemotaxis QF06_04135 ENOG4105XVF Competence transcription factor QF06_04140 ENOG4105CYX Short-chain dehydrogenase reductase Sdr QF06_04145 ENOG4105X3H Excalibur domain protein QF06_04150 ENOG4105E1V na solute symporter QF06_04155 ENOG4106CAD Protein of unknown function (DUF3311) QF06_04160 ENOG41060YP QF06_04175 ENOG4107SCK Monooxygenase QF06_04180 ENOG4108INS Transcriptional regulator QF06_04205 ENOG4105TRI Hydrolase QF06_04220 ENOG4108KK1 membrane protein AbrB duplication QF06_04225 ENOG4106K7D Major facilitator family transporter QF06_04230 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) QF06_04250 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation QF06_04260 ENOG4105EYH Exonuclease QF06_04310 ENOG4105ERH Fumarylacetoacetate hydrolase QF06_04320 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin QF06_04330 ENOG4105CAQ asparagine synthetase QF06_04345 ENOG4105UQX Mate efflux family protein QF06_04350 ENOG4106HBX Transcriptional Regulator AraC Family QF06_04355 ENOG4105ETE Transcriptional regulator (LacI family QF06_04360 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) QF06_04365 ENOG4105SF0 DinB family QF06_04370 ENOG4108ZUB Lysine exporter protein (Lyse ygga) QF06_04375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family QF06_04380 ENOG4105MYW Pentapeptide repeat protein QF06_04385 ENOG4107S9D Alpha beta hydrolase QF06_04390 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) QF06_04395 ENOG4107RIQ Sulfate adenylate transferase QF06_04400 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) QF06_04405 ENOG4108N5B 2-phosphosulfolactate phosphatase QF06_04410 ENOG41061P3 phosphosulfolactate synthase QF06_04420 ENOG4105DIA mandelate racemase muconate lactonizing QF06_04425 ENOG4107RCC Major Facilitator Superfamily QF06_04430 ENOG4108SZE gCN5-related N-acetyltransferase QF06_04435 ENOG4105MA6 gCN5-related N-acetyltransferase QF06_04445 ENOG4108VPT UPF0234 protein QF06_04450 ENOG4105QNR S1 RNA binding domain protein QF06_04470 ENOG4105K7K Transcriptional regulator QF06_04480 ENOG410751J QF06_04485 ENOG4105D4Y metalloprotease QF06_04490 ENOG4105EPR degv family QF06_04495 ENOG4107AYK membrAne QF06_04505 ENOG41073B9 QF06_04510 ENOG4108KP7 hydrolase QF06_04515 ENOG4108MXZ Esterase QF06_04520 ENOG4105VG1 fes assembly suf system protein QF06_04525 ENOG4105IQ5 FAD linked oxidase domain protein QF06_04535 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase QF06_04550 ENOG4105C8Y Acetylornithine aminotransferase QF06_04555 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain QF06_04565 ENOG4105DBV ornithine carbamoyltransferase QF06_04590 ENOG4107RMD Basic membrane lipoprotein QF06_04605 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) QF06_04610 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) QF06_04620 ENOG4105C3U ABC transporter QF06_04625 ENOG4108JQ7 (ABC) transporter QF06_04640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component QF06_04650 ENOG4105C31 Tryptophanyl-tRNA synthetase QF06_04655 ENOG4108J59 Extracellular solute-binding protein, family 5 QF06_04660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component QF06_04665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component QF06_04675 ENOG4108JQ7 (ABC) transporter QF06_04690 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) QF06_04695 ENOG4108ZCF integral membrane protein QF06_04700 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis QF06_04710 ENOG4105DPN Oligoendopeptidase f QF06_04725 ENOG4105T58 Dithiol-disulfide isomerase QF06_04730 ENOG4108Z18 K06886 hemoglobin QF06_04735 ENOG4105E4C Lytic transglycosylase catalytic QF06_04740 ENOG4105MIX Adenylate cyclase QF06_04755 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) QF06_04760 ENOG4105EMS pseudouridine synthase QF06_04775 ENOG4105ETU transcriptional activator (TenA QF06_04780 ENOG4108VEU Thiamine monophosphate synthase QF06_04795 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) QF06_04800 ENOG4105D06 uba thif-type nad fad binding protein QF06_04805 ENOG4105DWF phosphomethylpyrimidine kinase QF06_04810 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH QF06_04815 ENOG4107A88 QF06_04865 ENOG4105ENA helicase QF06_04880 ENOG4108ZMI UPF0477 protein QF06_04890 ENOG4105C28 cystathionine QF06_04895 ENOG4105C28 cystathionine QF06_04900 ENOG4105D9U N-acetyltransferase QF06_04905 ENOG4105JHY Membrane QF06_04940 ENOG4106BHF QF06_04970 ENOG4108PSK reductase QF06_04985 ENOG4105DM4 PTS System QF06_04990 ENOG4105DG6 mannose-6-phosphate isomerase QF06_04995 ENOG4105G7B Protein of unknown function (DUF2992) QF06_05000 ENOG4105VMI -acetyltransferase QF06_05010 ENOG4108Z66 YbaK ebsC protein QF06_05025 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) QF06_05035 ENOG4108ZJ4 polysaccharide deacetylase QF06_05040 ENOG4107CUJ Protein of unknown function (DUF2690) QF06_05060 ENOG4108IEG Formate dehydrogenase Alpha subunit QF06_05085 ENOG4106A3M Cytochrome p-450 QF06_05090 ENOG41087PP glycosyltransferase MGT family QF06_05110 ENOG4105EXQ uroporphyrinogen iii synthase hem4 QF06_05115 ENOG4105C4B ABC transporter, permease QF06_05120 ENOG4108IXI (ABC) transporter QF06_05130 ENOG4105Q95 Cupin 2, conserved barrel domain protein QF06_05145 ENOG4105D2H Uronic isomerase QF06_05150 ENOG4105CT4 transporter QF06_05155 ENOG4105DG4 malate L-lactate dehydrogenase QF06_05160 ENOG4105CPQ Dehydrogenase QF06_05165 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) QF06_05170 ENOG4105DMW Dehydrogenase reductase QF06_05175 ENOG4108I5G Major Facilitator superfamily QF06_05180 ENOG4107KJX Transcriptional regulator QF06_05185 ENOG4107QZW Altronate oxidoreductase QF06_05190 ENOG4105CTX dehydratase QF06_05195 ENOG4107TSN permease QF06_05205 ENOG4105JD4 ATPase yjob QF06_05220 ENOG41068K0 YCII-related domain QF06_05225 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase QF06_05230 ENOG4105KWG Pfam:DUF1696 QF06_05235 ENOG4105K7W phage-related replication protein QF06_05240 ENOG4105WEF catalase QF06_05245 ENOG410635T phage-like element pbsx protein QF06_05285 ENOG4108TFU terminase (Small subunit) QF06_05290 ENOG4105IG6 Phage terminase, large subunit QF06_05295 ENOG4108MDF Phage Portal Protein QF06_05320 ENOG41060SN QF06_05335 ENOG4105PQS phage protein QF06_05340 ENOG4105FR7 XkdM protein, phage-like element PBSX QF06_05345 ENOG4105MTC XkdN-like protein QF06_05350 ENOG4108FKH Transglycosylase SLT domain QF06_05355 ENOG4108WZM domain protein QF06_05360 ENOG4105X7F QF06_05370 ENOG4105MFU Protein of unknown function (DUF2634) QF06_05375 ENOG41066EA baseplate J family protein QF06_05380 ENOG410906S phage-like element pbsx protein xkdt QF06_05390 ENOG41068G1 QF06_05420 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase QF06_05435 ENOG4105CJ3 phosphate transporter QF06_05440 ENOG4107GRR phosphate transport regulator QF06_05445 ENOG4107R7I amino acid QF06_05455 ENOG4105EDW glycosyl transferase, family 39 QF06_05460 ENOG4105CKK Glycosyl transferase, family 2 QF06_05465 ENOG4105C0H protease QF06_05475 ENOG4108ME1 Peptidase M55 D-aminopeptidase QF06_05480 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component QF06_05485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component QF06_05490 ENOG4105C3U ABC transporter QF06_05500 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A QF06_05505 ENOG4105DTQ mandelate racemase muconate lactonizing QF06_05510 ENOG4107SN7 NLP P60 protein QF06_05515 ENOG4108JQ7 (ABC) transporter QF06_05520 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) QF06_05525 ENOG4107TUM Amidinotransferase QF06_05530 ENOG4108S4H thioesterase Superfamily protein QF06_05535 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) QF06_05555 ENOG4108428 Inherit from COG: -acetyltransferase QF06_05565 ENOG41080TC multidrug resistance protein QF06_05570 ENOG4105CIY formyltetrahydrofolate deformylase QF06_05575 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) QF06_05590 ENOG4105K56 Transcriptional regulator QF06_05595 ENOG4108ZHJ Organic hydroperoxide resistance protein QF06_05605 ENOG4107Y2X deaminase QF06_05610 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) QF06_05615 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin QF06_05625 ENOG4108W7F transporter, permease QF06_05630 ENOG4108JJB ABC transporter QF06_05635 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein QF06_05640 ENOG4108X43 YKOF domain protein QF06_05645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family QF06_05650 ENOG41062D9 Histidine kinase QF06_05660 ENOG4106849 propeptide, pepSY amd peptidase M4 QF06_05670 ENOG4105CJW magnesium transporter QF06_05675 ENOG4105V75 Transcriptional regulator QF06_05715 ENOG4105DQE DNA ligase QF06_05720 ENOG4105FDF Could be involved in DNA repair (By similarity) QF06_05725 ENOG4105BZU Histidine kinase QF06_05730 ENOG4107T5V SNARE associated Golgi QF06_05735 ENOG4107TS3 membrane protein, TerC QF06_05740 ENOG4108WZW RNA polymerase sigma QF06_05750 ENOG410681C small acid-soluble spore protein QF06_05760 ENOG4105D0M Protease HtpX homolog QF06_05770 ENOG4108TGC Acyltransferase QF06_05775 ENOG4105BZU Histidine kinase QF06_05780 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) QF06_05785 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) QF06_05790 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) QF06_05795 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase QF06_05805 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit QF06_05810 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) QF06_05815 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) QF06_05820 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) QF06_05840 ENOG4105BZU Histidine kinase QF06_05845 ENOG41090MY MarR family Transcriptional regulator QF06_05850 ENOG4105ER2 Ompa motb domain protein QF06_05855 ENOG4105E14 MotA TolQ exbB proton channel QF06_05865 ENOG4108K88 Membrane QF06_05870 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) QF06_05875 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase QF06_05880 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) QF06_05885 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) QF06_05895 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr QF06_05900 ENOG4105FEA Spore maturation protein QF06_05935 ENOG4105F0V Cell wall hydrolase QF06_05950 ENOG4105C59 p-type ATPase QF06_05960 ENOG4105DC7 peptidase M24 QF06_05970 ENOG4105CID antiterminator QF06_05980 ENOG4105KRI phosphocarrier protein (HPr QF06_05985 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) QF06_05995 ENOG4105F6S Spore photoproduct lyase QF06_06005 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer QF06_06010 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase QF06_06015 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid QF06_06020 ENOG4105K4I Scp-like extracellular QF06_06030 ENOG4105BZU Histidine kinase QF06_06035 ENOG4105CHM Aminotransferase QF06_06040 ENOG4107R88 Chemotaxis protein (CheV) QF06_06045 ENOG4105UIN QF06_06055 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein QF06_06065 ENOG4105K6S Short-chain dehydrogenase reductase Sdr QF06_06070 ENOG4105EPM Diguanylate phosphodiesterase QF06_06075 ENOG4107IN1 Protein of unknown function (DUF1797) QF06_06080 ENOG4108XRC Protein of unknown function (DUF458) QF06_06110 ENOG4105NQC Flavodoxin QF06_06120 ENOG4105CH2 amidohydrolase QF06_06130 ENOG4105D8X mechanosensitive ion channel QF06_06135 ENOG4105D3R alkyl hydroperoxide reductase QF06_06140 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen QF06_06155 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) QF06_06160 ENOG4105D06 uba thif-type nad fad binding protein QF06_06165 ENOG4105CVM Molybdenum cofactor synthesis domain protein QF06_06170 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein QF06_06175 ENOG4108ZAF Molybdopterin QF06_06180 ENOG41067WU Molybdopterin converting factor (Subunit 1) QF06_06185 ENOG4105BZ1 (ABC) transporter QF06_06190 ENOG4105BZ1 (ABC) transporter QF06_06200 ENOG4107X8C Efflux transporter RND family MFP subunit QF06_06205 ENOG4105C19 ABC transporter QF06_06210 ENOG4107RBB ABC transporter, permease QF06_06215 ENOG4105E98 transcriptional regulator DeoR family QF06_06220 ENOG4105DE4 1-phosphofructokinase QF06_06225 ENOG4105DM4 PTS System QF06_06230 ENOG4105C3F Signal peptidase i QF06_06240 ENOG4105C5H ABC transporter QF06_06245 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) QF06_06265 ENOG4105BZU Histidine kinase QF06_06275 ENOG4107ZYR domain protein QF06_06285 ENOG4105CN5 Metallo-Beta-Lactamase QF06_06295 ENOG4108X4Q Hydrolase QF06_06300 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) QF06_06320 ENOG4105CPP Dehydrogenase, E1 component QF06_06325 ENOG4105C7S Dehydrogenase QF06_06330 ENOG4107QN2 dihydrolipoyl dehydrogenase QF06_06340 ENOG4105CXN decarboxylase QF06_06345 ENOG4105WBI UPF0223 protein QF06_06360 ENOG4105ECY inositol monophosphatase QF06_06370 ENOG4105JQZ Methyltransferase QF06_06410 ENOG4105CI3 gtp-binding protein typa QF06_06415 ENOG4105QA2 QF06_06430 ENOG4108IAB Phoh family QF06_06440 ENOG4105CSV Glutaminase QF06_06445 ENOG4105ZPI UPF0358 protein QF06_06450 ENOG4105CNI cell division protein FtsW QF06_06455 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) QF06_06465 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) QF06_06475 ENOG4105BZ9 Cytochrome C oxidase, subunit I QF06_06480 ENOG4105CCU oxidase (Subunit III) QF06_06485 ENOG41064X9 cytochrome C oxidase subunit IV QF06_06500 ENOG41080XQ Signal transduction protein with cbs domains QF06_06505 ENOG4106UY4 Inherit from COG: Scp-like extracellular QF06_06525 ENOG4105WUC UPF0298 protein QF06_06530 ENOG4106H78 methyltransferase QF06_06535 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) QF06_06540 ENOG4105H20 Sporulation integral membrane protein YlbJ QF06_06545 ENOG4105D78 K07001 NTE family protein QF06_06550 ENOG41063PX domain protein QF06_06555 ENOG4105CDE UPF0348 protein QF06_06565 ENOG4105KNH Nucleic acid-binding protein QF06_06590 ENOG4108V6E Cell division protein mraZ QF06_06595 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) QF06_06605 ENOG4105CJN penicillin-binding protein QF06_06610 ENOG4105CJN penicillin-binding protein QF06_06615 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) QF06_06620 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) QF06_06625 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) QF06_06630 ENOG4105CNI cell division protein FtsW QF06_06635 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) QF06_06640 ENOG4105D4A Cell wall formation (By similarity) QF06_06645 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) QF06_06650 ENOG4108R2U division initiation protein QF06_06660 ENOG4105K67 small basic protein QF06_06665 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) QF06_06670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) QF06_06680 ENOG4105FFI sigma-e processing peptidase spoiiga QF06_06685 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) QF06_06695 ENOG4105DKW ABC transporter QF06_06705 ENOG4105WR5 sporulation protein, YlmC YmxH family QF06_06710 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase QF06_06715 ENOG4105DFA alanine racemase domain protein QF06_06720 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) QF06_06725 ENOG41067XK integral membrane protein QF06_06730 ENOG4105DBK s4 domain protein QF06_06740 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) QF06_06750 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) QF06_06755 ENOG4105C34 Pseudouridine synthase QF06_06760 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) QF06_06770 ENOG4105CXT aspartate transcarbamylase QF06_06780 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain QF06_06785 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain QF06_06790 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) QF06_06795 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) QF06_06800 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) QF06_06805 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) QF06_06810 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) QF06_06820 ENOG4107S4M Sulfate adenylate transferase QF06_06825 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) QF06_06830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) QF06_06835 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein QF06_06840 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein QF06_06845 ENOG4105F23 Fibronectin-binding protein QF06_06855 ENOG4105DSJ YicC domain protein QF06_06860 ENOG4105KC4 UPF0296 protein QF06_06865 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) QF06_06875 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase QF06_06880 ENOG4105C25 Primosomal protein n' QF06_06885 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) QF06_06890 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) QF06_06895 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B QF06_06900 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs QF06_06905 ENOG4108ZF3 Phosphatase QF06_06910 ENOG4105D9P serine threonine protein kinase QF06_06915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) QF06_06920 ENOG4105DJV ribulose-phosphate 3-epimerase QF06_06925 ENOG4105FJ0 thiamine QF06_06935 ENOG4105VB9 50S ribosomal protein l28 QF06_06940 ENOG4108ZAA Alkaline-shock protein QF06_06945 ENOG4105DP4 dak2 domain fusion protein ylov QF06_06955 ENOG4105EJQ L-serine dehydratase QF06_06960 ENOG4105CB5 ATP-dependent DNA helicase recG QF06_06965 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) QF06_06975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase QF06_06980 ENOG4105CHR reductase QF06_06985 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) QF06_06990 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) QF06_06995 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) QF06_07000 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) QF06_07010 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) QF06_07020 ENOG4105K5M 30s ribosomal protein S16 QF06_07025 ENOG4108BW8 UPF0109 protein QF06_07035 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) QF06_07040 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) QF06_07045 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) QF06_07050 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) QF06_07055 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) QF06_07065 ENOG4105VM1 flagellar QF06_07070 ENOG4105CMV Succinyl-CoA synthetase subunit beta QF06_07075 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha QF06_07080 ENOG4105C79 DNA protecting protein DprA QF06_07085 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) QF06_07090 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) QF06_07095 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) QF06_07100 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) QF06_07105 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) QF06_07115 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) QF06_07120 ENOG4108ZC9 flagellar basal-body rod protein flgc QF06_07125 ENOG4105VQ0 flagellar hook-basal body complex protein fliE QF06_07130 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) QF06_07135 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) QF06_07150 ENOG4106YF4 Flagellar biosynthesis chaperone QF06_07160 ENOG410696Y Flagellar hook-length control protein QF06_07165 ENOG410822I Flagellar hook capping protein QF06_07170 ENOG4108JQA flagellar QF06_07175 ENOG41068WV flagellar FlbD family protein QF06_07185 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) QF06_07190 ENOG4105DD5 Flagellar motor switch protein QF06_07195 ENOG4107YTP response regulator receiver protein QF06_07205 ENOG4105CN7 Flagellar biosynthetic protein FliP QF06_07210 ENOG4105VS8 Flagellar biosynthetic protein fliq QF06_07215 ENOG4105D19 Role in flagellar biosynthesis (By similarity) QF06_07220 ENOG4105D00 flagellar biosynthetic protein flhB QF06_07225 ENOG4105D7B Flagellar biosynthesis protein flha QF06_07230 ENOG4105FZW flagellar biosynthesis regulator FlhF QF06_07240 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) QF06_07245 ENOG4105CBS Chea signal transduction histidine kinase QF06_07250 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis QF06_07265 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) QF06_07275 ENOG4105CE9 30S ribosomal protein S2 QF06_07280 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) QF06_07290 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) QF06_07295 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) QF06_07300 ENOG4105KNE Phosphatidate cytidylyltransferase QF06_07310 ENOG4105DZP Membrane-associated zinc metalloprotease QF06_07315 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) QF06_07320 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) QF06_07345 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) QF06_07350 ENOG4105CHV Transcription elongation factor NusA QF06_07355 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination QF06_07360 ENOG4105VHM ribosomal protein QF06_07365 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) QF06_07370 ENOG4105W7A Protein of unknown function (DUF503) QF06_07375 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) QF06_07380 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) QF06_07385 ENOG4105DTN riboflavin biosynthesis protein ribF QF06_07390 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) QF06_07395 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) QF06_07405 ENOG4105C1V Peptidase, M16 QF06_07415 ENOG4105E35 Dipicolinate synthase subunit A QF06_07420 ENOG4108S0H Dipicolinic acid synthetase, b subunit QF06_07425 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) QF06_07435 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) QF06_07445 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit QF06_07455 ENOG4105CNU cell division protein FtsK QF06_07460 ENOG4105FDP GntR family transcriptional regulator QF06_07480 ENOG4108RKS Short-chain dehydrogenase reductase Sdr QF06_07485 ENOG4105XZV Protein of unknown function (DUF3243) QF06_07500 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase QF06_07505 ENOG4105CEV competence damage-inducible protein QF06_07515 ENOG4108A04 Beta-lactamase QF06_07520 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) QF06_07525 ENOG4105D48 metallophosphoesterase QF06_07530 ENOG4105MCT stage V sporulation protein S QF06_07540 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) QF06_07545 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) QF06_07560 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) QF06_07565 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) QF06_07575 ENOG4105IIP Membrane QF06_07580 ENOG4105W1N transcriptional regulator QF06_07585 ENOG4108151 Beta-lactamase domain protein QF06_07595 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase QF06_07605 ENOG4107QKG PfaD family QF06_07610 ENOG41062T2 Acyl carrier protein QF06_07615 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase QF06_07620 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase QF06_07625 ENOG4108MGH Enoyl-CoA hydratase QF06_07630 ENOG4108KQ6 Enoyl-CoA hydratase QF06_07635 ENOG4105C0W non-ribosomal peptide synthetase QF06_07640 ENOG4107SQU synthase QF06_07650 ENOG4105C0W non-ribosomal peptide synthetase QF06_07660 ENOG4106A3M Cytochrome p-450 QF06_07675 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin QF06_07685 ENOG4105K7W phage-related replication protein QF06_07690 ENOG4108X3M OsmC Ohr family protein QF06_07695 ENOG410814C multidrug resistance protein QF06_07715 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) QF06_07720 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) QF06_07735 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) QF06_07740 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) QF06_07745 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) QF06_07750 ENOG4105U6W MutT NUDIX family protein QF06_07755 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase QF06_07760 ENOG4106F1P AAA ATPase, central domain protein QF06_07765 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) QF06_07770 ENOG4105CXI aluminum resistance protein QF06_07775 ENOG4105KV4 Transcriptional regulator QF06_07780 ENOG4105C5F glutamine synthetase QF06_07785 ENOG41079P0 QF06_07830 ENOG410907G QF06_07835 ENOG4105CT4 transporter QF06_07840 ENOG4105DSG hydrolase family 43 QF06_07845 ENOG4105E2R ROK family QF06_07850 ENOG4105C93 Xylose Isomerase QF06_07855 ENOG4105CMG Carbohydrate kinase QF06_07865 ENOG4105C54 Major Facilitator superfamily QF06_07870 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) QF06_07885 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) QF06_07945 ENOG4108Q8B Spore germination protein QF06_07950 ENOG4108NHD germination protein QF06_07965 ENOG4105FVX QF06_07975 ENOG4105K7W phage-related replication protein QF06_07985 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) QF06_07990 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) QF06_08000 ENOG4108SVB resolvase QF06_08005 ENOG4105VPS UPF0291 protein QF06_08010 ENOG4105CV1 Transketolase (EC 2.2.1.1) QF06_08030 ENOG4107QIV Cytochrome c biogenesis protein QF06_08055 ENOG4107DZX Small, acid-soluble spore protein P QF06_08065 ENOG4108I0Z Aconitate hydratase QF06_08070 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen QF06_08085 ENOG41067CD Small, acid-soluble spore protein Tlp QF06_08095 ENOG4105MI2 QF06_08100 ENOG4105W8X HesB YadR YfhF-family protein QF06_08105 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) QF06_08110 ENOG4105K4P CoA-binding domain protein QF06_08115 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) QF06_08135 ENOG4107QWR cellulase (EC 3.2.1.4) QF06_08145 ENOG4108MYR Secreted protein QF06_08150 ENOG4107SYN Glycosyl hydrolases family 43 QF06_08160 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase QF06_08165 ENOG4107T5V SNARE associated Golgi QF06_08175 ENOG4107QX3 carboxylase QF06_08180 ENOG4105E39 Enoyl-CoA hydratase QF06_08185 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase QF06_08190 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit QF06_08195 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase QF06_08200 ENOG4105CEY Amp-dependent synthetase and ligase QF06_08205 ENOG4105C1G acyl-Coa dehydrogenase QF06_08215 ENOG4105F32 YngK protein QF06_08220 ENOG4106U2H Protein of unknown function (DUF1360) QF06_08235 ENOG4105C0W non-ribosomal peptide synthetase QF06_08245 ENOG4105C0W non-ribosomal peptide synthetase QF06_08250 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family QF06_08255 ENOG4108N2V aldose 1-epimerase QF06_08260 ENOG4107QJQ Mate efflux family protein QF06_08285 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) QF06_08290 ENOG4105SKE transcriptional Regulator LysR family QF06_08295 ENOG4105CB2 alcohol dehydrogenase QF06_08300 ENOG4105BZ8 glutamate synthase QF06_08305 ENOG4105CBC glutamate synthase QF06_08310 ENOG4105C5Q Transcriptional regulator QF06_08315 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) QF06_08320 ENOG4105II7 pyrroline-5-carboxylate reductase QF06_08340 ENOG4108UB7 QF06_08345 ENOG41068WN QF06_08360 ENOG4105CJ1 ABC, transporter QF06_08370 ENOG4105IE8 Alpha-ketoglutarate permease QF06_08375 ENOG4107U6E carbohydrate kinase FGGY QF06_08385 ENOG4108J2R molybdopterin oxidoreductase QF06_08395 ENOG4107QNK )-transporter QF06_08400 ENOG4105CIB oxidoreductase Domain protein QF06_08405 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) QF06_08410 ENOG4105ETE Transcriptional regulator (LacI family QF06_08430 ENOG4105EC8 Methyl-accepting chemotaxis QF06_08440 ENOG4108YQE rare lipoprotein a QF06_08445 ENOG4105XPP Protein of unknown function (DUF1275) QF06_08450 ENOG4108NR7 pectate lyase QF06_08455 ENOG4108RAV Conserved protein QF06_08465 ENOG4105F0F Oxalate decarboxylase QF06_08485 ENOG41073R8 VanW family QF06_08495 ENOG4105VMP Transcriptional regulator QF06_08500 ENOG4105NX3 Membrane QF06_08510 ENOG4108Q5Y Membrane QF06_08520 ENOG4108V4B ThiJ pfpI QF06_08525 ENOG4108J4B Beta-lactamase QF06_08540 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) QF06_08545 ENOG4107T94 Endo-14-beta-xylanase QF06_08550 ENOG4105YB8 TM2 domain containing protein QF06_08615 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) QF06_08620 ENOG4106BHF QF06_08635 ENOG4108Z7R Chaperone CsaA QF06_08640 ENOG4105FTV AraC Family Transcriptional Regulator QF06_08645 ENOG4108HJF gCN5-related N-acetyltransferase QF06_08655 ENOG4108W8B Beta-lactamase domain protein QF06_08665 ENOG4105D29 Helix-turn-helix type 11 domain protein QF06_08675 ENOG4105KTU Transcriptional regulator, arsr family QF06_08685 ENOG4108SJC Membrane QF06_08705 ENOG4105ECK Fatty Acid Desaturase QF06_08710 ENOG4108ZGX Histidine kinase QF06_08715 ENOG4108S01 response regulator QF06_08720 ENOG41069ER domain protein QF06_08725 ENOG4105C9U ATP-dependent DNA helicase RecQ QF06_08735 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) QF06_08740 ENOG4105SCY DNAK suppressor QF06_08780 ENOG4105C26 Dehydrogenase QF06_08785 ENOG4105EWU Squalene--hopene cyclase QF06_08790 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) QF06_08795 ENOG4105C8J )-transporter QF06_08800 ENOG4105C09 Bile acid QF06_08805 ENOG4105C7S Dehydrogenase QF06_08815 ENOG4107T89 von Willebrand factor, type A QF06_08820 ENOG4105GMT ATPase associated with various cellular activities aaa_5 QF06_08830 ENOG4105K4H Nlp p60 protein QF06_08835 ENOG41087PP glycosyltransferase MGT family QF06_08845 ENOG4107QMU Mate efflux family protein QF06_08850 ENOG4106SCS STAS domain QF06_08870 ENOG4105FR1 rard protein QF06_08885 ENOG4105C6Z Gluconate QF06_08890 ENOG41090U3 tautomerase QF06_08905 ENOG4105FBA Phospholipase Carboxylesterase QF06_08920 ENOG4105E1V na solute symporter QF06_08940 ENOG4108VXD carboxy-peptidase QF06_08945 ENOG4105D3A purine nucleoside phosphorylase DeoD-type QF06_08950 ENOG4106Z5R QF06_08955 ENOG410841Q phosphoesterase PA-phosphatase related protein QF06_08980 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein QF06_08985 ENOG4108TSC N-acetyltransferase QF06_08990 ENOG4107S4Y M20 DapE family protein YgeY QF06_09005 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) QF06_09040 ENOG4107T32 3-phytase (EC 3.1.3.8) QF06_09045 ENOG4105C5E polysaccharide biosynthesis protein QF06_09050 ENOG4105E0X reductase QF06_09055 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) QF06_09075 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) QF06_09080 ENOG41090WU lipolytic protein G-D-S-L family QF06_09085 ENOG4108KF3 Electron transport protein SCO1 SenC QF06_09095 ENOG4105C7B Threonine dehydratase QF06_09105 ENOG4108UT2 hemolysin iii QF06_09115 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) QF06_09130 ENOG4107YX5 Pfam:DUF548 QF06_09135 ENOG4108Y6J UPF0403 protein QF06_09140 ENOG4105C01 Dihydroxy-acid dehydratase QF06_09155 ENOG4108V06 Glutathione peroxidase QF06_09160 ENOG4105CVG Homoserine O-transsuccinylase QF06_09200 ENOG41081VK Ribonuclease QF06_09220 ENOG410890F Dynamin family QF06_09230 ENOG41065KQ synthase QF06_09235 ENOG4105C2W permease QF06_09240 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) QF06_09245 ENOG4105CTD carboxy-peptidase QF06_09250 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) QF06_09255 ENOG4108UHU Aldolase QF06_09260 ENOG4105D7K pfkb domain protein QF06_09265 ENOG4108M60 Transcriptional regulator QF06_09275 ENOG4105CHR reductase QF06_09280 ENOG4105DVT helicase QF06_09290 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) QF06_09300 ENOG4108UKS UPF0398 protein QF06_09305 ENOG4107X2U Inherit from COG: Exonuclease-like protein QF06_09310 ENOG4108I5C dEAD DEAH box helicase QF06_09360 ENOG4105BZ4 penicillin-binding protein QF06_09370 ENOG4105CSM endonuclease III QF06_09380 ENOG4105C5S asparaginyl-tRNA synthetase QF06_09385 ENOG4105CHM Aminotransferase QF06_09395 ENOG4105DVT helicase QF06_09400 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) QF06_09405 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) QF06_09410 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) QF06_09415 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase QF06_09420 ENOG4105DJ0 Poly(A) Polymerase QF06_09425 ENOG4105CPK Glycosyl transferase (Group 1 QF06_09430 ENOG4105FJR Lmbe family QF06_09435 ENOG4108Z5K methylglyoxal synthase QF06_09440 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) QF06_09445 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase QF06_09450 ENOG4108JYZ YitT family QF06_09470 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) QF06_09490 ENOG41068YB TPR repeat-containing protein QF06_09495 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase QF06_09505 ENOG4105CIH Imidazole acetol-phosphate transaminase QF06_09515 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) QF06_09520 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase QF06_09530 ENOG4108I0Q anthranilate phosphoribosyltransferase QF06_09535 ENOG4105CRQ synthase (Component I) QF06_09540 ENOG4105KHN chorismate mutase QF06_09545 ENOG4105D49 3-dehydroquinate synthase QF06_09550 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase QF06_09555 ENOG4105BZU Histidine kinase QF06_09560 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) QF06_09565 ENOG4105EAH synthase QF06_09570 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) QF06_09575 ENOG4105XXQ heptaprenyl diphosphate synthase component I QF06_09585 ENOG4105EUJ GTP cyclohydrolase i QF06_09590 ENOG4105K70 DNA-binding protein QF06_09595 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) QF06_09610 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase QF06_09615 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) QF06_09620 ENOG41065D1 QF06_09625 ENOG4105S2F QF06_09635 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) QF06_09640 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) QF06_09645 ENOG4105CAT Cytidine monophosphate kinase QF06_09655 ENOG4105MSI germination protein ypeb QF06_09665 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) QF06_09670 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase QF06_09685 ENOG4107RGJ metallophosphoesterase QF06_09700 ENOG4105I7S Abortive infection protein QF06_09705 ENOG4105C9U ATP-dependent DNA helicase RecQ QF06_09710 ENOG4105T7X QF06_09720 ENOG4108SAX Membrane QF06_09725 ENOG4108JQ1 Dehydrogenase QF06_09730 ENOG4105FF2 Type I DHQase QF06_09745 ENOG4105BZU Histidine kinase QF06_09750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family QF06_09755 ENOG4105CRE cytochrome C QF06_09760 ENOG4107TWT Cytochrome c biogenesis protein QF06_09770 ENOG4105FE9 pseudouridine synthase QF06_09780 ENOG4108JIC nucleoside recognition domain protein QF06_09785 ENOG4105DZ1 carboxypeptidase QF06_09795 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) QF06_09800 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) QF06_09815 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) QF06_09820 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) QF06_09825 ENOG4108R6K riboflavin synthase, subunit alpha QF06_09830 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) QF06_09840 ENOG4105C3F Signal peptidase i QF06_09855 ENOG4107ZE5 PPIases accelerate the folding of proteins QF06_09860 ENOG4105PTM secreted protein QF06_09865 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) QF06_09875 ENOG4105G6R Stage v sporulation protein ae QF06_09885 ENOG4105CZ3 stage V sporulation protein ad QF06_09890 ENOG41090VF Stage v sporulation protein ac QF06_09905 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) QF06_09910 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) QF06_09915 ENOG41082AN stage II sporulation protein QF06_09920 ENOG4105DZ1 carboxypeptidase QF06_09925 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) QF06_09930 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) QF06_09935 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) QF06_09945 ENOG4105I3K Ferric uptake regulator, Fur family QF06_09950 ENOG4105MZ9 stage II sporulation protein m QF06_09965 ENOG4105DFD Na H antiporter QF06_09970 ENOG4108IJ0 Aspartate ammonia-lyase QF06_09975 ENOG4105HDK L-asparaginase QF06_09980 ENOG4108IMY Transcriptional regulator QF06_09990 ENOG4108YZ4 nudix hydrolase QF06_10000 ENOG4105CPC Aldo Keto reductase QF06_10020 ENOG4106HZJ QF06_10025 ENOG4105RHY Pfam:UPF0157 QF06_10030 ENOG4105KAC Antibiotic biosynthesis monooxygenase QF06_10035 ENOG4108XET gCN5-related N-acetyltransferase QF06_10045 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) QF06_10055 ENOG4105E5W Transporter QF06_10060 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase QF06_10075 ENOG4108IXY short-chain dehydrogenase reductase QF06_10080 ENOG41069FQ Metallo-beta-lactamase superfamily QF06_10085 ENOG4105II7 pyrroline-5-carboxylate reductase QF06_10095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase QF06_10105 ENOG410861F 50S ribosomal protein L33 QF06_10110 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) QF06_10115 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase QF06_10120 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) QF06_10125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) QF06_10135 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) QF06_10140 ENOG4108NA0 Uncharacterized conserved protein (COG2071) QF06_10145 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) QF06_10150 ENOG4108HNZ carboxyl transferase QF06_10155 ENOG4108ZVT methylmalonyl-coA epimerase QF06_10160 ENOG4108VZI ErfK ybiS ycfS ynhG family protein QF06_10165 ENOG4108QEG Membrane QF06_10170 ENOG4105CDA abc transporter atp-binding protein QF06_10175 ENOG4105E5Q amino acid AbC transporter QF06_10180 ENOG4108HW3 (ABC) transporter QF06_10185 ENOG4108Y6J UPF0403 protein QF06_10190 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) QF06_10205 ENOG4105C7S Dehydrogenase QF06_10210 ENOG4105CPP Dehydrogenase, E1 component QF06_10225 ENOG4105CKM Branched-chain carboxylic acid kinase QF06_10230 ENOG4107RDP Dehydrogenase QF06_10240 ENOG4108JUB Transcriptional regulator QF06_10245 ENOG4106CCJ Protein of unknown function (DUF2627) QF06_10250 ENOG4105CR4 methylisocitrate lyase QF06_10255 ENOG4105DXD 2-methylcitrate dehydratase QF06_10265 ENOG4105C1G acyl-Coa dehydrogenase QF06_10270 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase QF06_10280 ENOG4108QXE glycerophosphoryl diester phosphodiesterase QF06_10285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase QF06_10295 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase QF06_10300 ENOG4107QQR Sporulation QF06_10305 ENOG4105S1Z Stage IV sporulation protein B QF06_10310 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) QF06_10315 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) QF06_10320 ENOG4105DX0 Hemolysin A QF06_10330 ENOG4105CTB Polyprenyl synthetase QF06_10335 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) QF06_10340 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) QF06_10345 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) QF06_10350 ENOG4105M7K Involved in the transcription termination process (By similarity) QF06_10355 ENOG4108ZSR alkaline shock protein QF06_10360 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase QF06_10380 ENOG410644B Stage III sporulation protein af QF06_10390 ENOG4105KQ4 Stage iii sporulation protein ad QF06_10395 ENOG4108CQH stage III sporulation protein AC QF06_10400 ENOG4105KR5 Stage iii sporulation protein QF06_10405 ENOG4105CD2 stage iii sporulation protein aa QF06_10415 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) QF06_10420 ENOG4105DC7 peptidase M24 QF06_10425 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) QF06_10435 ENOG4105CBJ Metal-dependent enzyme QF06_10450 ENOG4105KST dependent repressor QF06_10455 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) QF06_10460 ENOG4105WZW rhodanese family QF06_10465 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor QF06_10470 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor QF06_10475 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) QF06_10480 ENOG4105C0D helicase QF06_10495 ENOG4108IMY Transcriptional regulator QF06_10505 ENOG4105VFR signal peptidase QF06_10565 ENOG4105C37 (CBS) domain QF06_10590 ENOG4105C5X domain protein QF06_10615 ENOG4105E0M Sulfatase QF06_10630 ENOG4107ZXI Rhomboid family QF06_10635 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase QF06_10640 ENOG4105WDJ 50S ribosomal protein L33 QF06_10660 ENOG41068DG YceG-like family QF06_10665 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) QF06_10670 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) QF06_10675 ENOG4105E2Z phosphate ABC transporter (Permease QF06_10680 ENOG4105C8U phosphate abc transporter QF06_10685 ENOG4105CVA phosphate QF06_10690 ENOG4107RF6 penicillin-binding protein QF06_10700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) QF06_10705 ENOG4105SXS Protein of unknown function (DUF456) QF06_10720 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) QF06_10725 ENOG41063Y9 QF06_10730 ENOG4108U5J '-nucleotidase QF06_10735 ENOG4105N80 Ferric uptake regulator, Fur family QF06_10740 ENOG4108JYZ YitT family QF06_10745 ENOG41069ZM Protein of unknown function (DUF2624) QF06_10750 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) QF06_10765 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) QF06_10770 ENOG4105EGD dinuclear metal center protein, YbgI family QF06_10785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) QF06_10790 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) QF06_10795 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 QF06_10800 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) QF06_10810 ENOG4105C38 Glycyl-tRNA synthetase beta subunit QF06_10815 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit QF06_10820 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) QF06_10825 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) QF06_10830 ENOG4105KG3 cytidine deaminase QF06_10835 ENOG4107YR5 Diacylglycerol kinase QF06_10840 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) QF06_10845 ENOG4105CTJ Metal Dependent Phosphohydrolase QF06_10850 ENOG4105C9A Phoh family QF06_10855 ENOG4105EI1 sporulation protein yqfd QF06_10860 ENOG41068P3 sporulation protein YqfC QF06_10870 ENOG4105DI5 UPF0365 protein QF06_10875 ENOG4105F7J membrane-bound serine protease QF06_10880 ENOG4105KTH gatB Yqey QF06_10895 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) QF06_10900 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) QF06_10905 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) QF06_10915 ENOG4105CFG Acts as a chaperone (By similarity) QF06_10920 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ QF06_10925 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) QF06_10930 ENOG4105CSA Coproporphyrinogen iii oxidase QF06_10945 ENOG4108ZRV stage ii sporulation protein p QF06_10950 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) QF06_10955 ENOG41082YS Binds directly to 16S ribosomal RNA QF06_10960 ENOG4105TQK DNA polymerase iii, delta' subunit QF06_10970 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 QF06_10975 ENOG4108UK2 deaminase QF06_10980 ENOG4105KQC Competence protein QF06_10990 ENOG4108D32 Methyltransferase QF06_11000 ENOG4108WF2 Metal Dependent Phosphohydrolase QF06_11005 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) QF06_11010 ENOG410812S Rna-binding protein QF06_11015 ENOG4105E2X shikimate dehydrogenase QF06_11020 ENOG4105CQW ribosome biogenesis GTPase YqeH QF06_11025 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase QF06_11040 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase QF06_11045 ENOG41080BT SNARE associated Golgi QF06_11060 ENOG4105WFK nuclease QF06_11065 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) QF06_11070 ENOG4107Y5K Resolvase QF06_11075 ENOG4108UXE Protein tyrosine phosphatase QF06_11080 ENOG4105D6J arsenicaL-resistance protein QF06_11085 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase QF06_11090 ENOG41085FC arsR family transcriptional regulator QF06_11115 ENOG41064HX Suppressor of fused protein (SUFU) QF06_11130 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase QF06_11165 ENOG410906S phage-like element pbsx protein xkdt QF06_11170 ENOG41066EA baseplate J family protein QF06_11175 ENOG4105MFU Protein of unknown function (DUF2634) QF06_11185 ENOG4105X7F QF06_11190 ENOG4108WZM domain protein QF06_11195 ENOG4108FKH Transglycosylase SLT domain QF06_11200 ENOG4105MTC XkdN-like protein QF06_11210 ENOG4105FR7 XkdM protein, phage-like element PBSX QF06_11215 ENOG4105PQS phage protein QF06_11230 ENOG41060SN QF06_11265 ENOG4106CGH Phage Mu protein F like protein QF06_11270 ENOG4108MDF Phage Portal Protein QF06_11275 ENOG4105IG6 Phage terminase, large subunit QF06_11295 ENOG4106129 QF06_11305 ENOG4105QBX endodeoxyribonuclease RusA QF06_11320 ENOG4108PNI recT protein QF06_11325 ENOG4108NF7 phage-type endonuclease QF06_11345 ENOG4106A7E Transcriptional regulator QF06_11350 ENOG41067QW Transcriptional regulator QF06_11355 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) QF06_11375 ENOG4108SWU Histidine kinase QF06_11380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family QF06_11385 ENOG4105DHF Membrane QF06_11390 ENOG4108UYN gCN5-related N-acetyltransferase QF06_11395 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein QF06_11400 ENOG41068VA QF06_11405 ENOG41087NI Sulfite exporter TauE/SafE QF06_11410 ENOG4105VFE sira family QF06_11415 ENOG4107TPS domain protein QF06_11425 ENOG4105VFE sira family QF06_11430 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase QF06_11435 ENOG4105XTG Pfam:DUF156 QF06_11440 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein QF06_11445 ENOG41090E6 transcriptional regulator MERR family QF06_11460 ENOG4105C37 (CBS) domain QF06_11470 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family QF06_11475 ENOG4105H3G oxidoreductase QF06_11480 ENOG4105PGM cation diffusion facilitator family transporter QF06_11485 ENOG41090U3 tautomerase QF06_11505 ENOG4105KMT branched-chain amino acid QF06_11510 ENOG4108UMN azlc family QF06_11515 ENOG4108ZRZ Transcriptional regulator (AsnC family) QF06_11520 ENOG41067XF inhibitor QF06_11535 ENOG41064BW Protein of unknown function (DUF2568) QF06_11545 ENOG41075D4 Aminoglycoside 6-adenylyltransferase QF06_11550 ENOG4105EA8 2-Nitropropane dioxygenase QF06_11555 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) QF06_11565 ENOG4107YCY Transcriptional regulator QF06_11575 ENOG4105CHR reductase QF06_11580 ENOG4108IUS Transketolase QF06_11585 ENOG4105CV1 Transketolase (EC 2.2.1.1) QF06_11590 ENOG4105C0R drug resistance transporter emrb qaca subfamily QF06_11595 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes QF06_11600 ENOG4108MEK Metal-binding protein YodA QF06_11605 ENOG410904A RNA polymerase QF06_11610 ENOG4105CPC Aldo Keto reductase QF06_11620 ENOG4108KAM Transcriptional regulator QF06_11625 ENOG4105C7F AcnD-accessory protein PrpF QF06_11630 ENOG41083Q9 chitosanase QF06_11635 ENOG4105X5K response regulator receiver protein QF06_11640 ENOG4108VQT Alpha beta hydrolase fold protein QF06_11645 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein QF06_11650 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein QF06_11655 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase QF06_11665 ENOG4105PGS Spore coat protein QF06_11670 ENOG4105E2A Dehydrogenase QF06_11685 ENOG4105VUF Transcriptional regulator QF06_11695 ENOG4105DQ4 alcohol dehydrogenase QF06_11700 ENOG4108Z0Z intracellular protease Pfpi family QF06_11705 ENOG4108HKT sucrose-6-phosphate hydrolase QF06_11710 ENOG4105F3R pts system mannose fructose sorbose family iid QF06_11715 ENOG4105ETZ PTS System QF06_11720 ENOG4108IQ3 PTS system QF06_11725 ENOG4105YHU PTS system QF06_11730 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family QF06_11735 ENOG4105C85 amino acid QF06_11740 ENOG4105N14 lysine exporter protein LysE YggA QF06_11745 ENOG4108NGU Transcriptional regulator QF06_11750 ENOG4105JVQ RNA Polymerase QF06_11755 ENOG4108P49 AntiSigma factor QF06_11760 ENOG4105EXC Acyl-transferase QF06_11765 ENOG4105WDR QF06_11770 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) QF06_11775 ENOG41082JN Transcriptional regulator QF06_11790 ENOG4105TMB Formate nitrite transporter QF06_11795 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) QF06_11800 ENOG4108JB9 formate dehydrogenase QF06_11815 ENOG4105C28 cystathionine QF06_11830 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) QF06_11845 ENOG4107XRG penicillin-binding protein QF06_11850 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) QF06_11855 ENOG4105DBI uridine monophosphokinase QF06_11860 ENOG4105CFP Peptidase U32 QF06_11865 ENOG4105XYU peptidase (U32 family) QF06_11870 ENOG4108VQJ O-methyltransferase QF06_11875 ENOG4105HHA aminodeoxychorismate lyase QF06_11880 ENOG4105VPH UPF0473 protein QF06_11885 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) QF06_11890 ENOG4105VBH UPF0297 protein QF06_11895 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) QF06_11900 ENOG4105C02 permease QF06_11905 ENOG4105CDA abc transporter atp-binding protein QF06_11910 ENOG4105CT1 (ABC) transporter QF06_11915 ENOG4105EAD ABC transporter QF06_11920 ENOG4105DRP amino acid AbC transporter QF06_11925 ENOG41060CR QF06_11935 ENOG4105C7H Helicase, RecD TraA family QF06_11945 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) QF06_11950 ENOG4105C3J Cysteine desulfurase QF06_11960 ENOG4105D1H recombination factor protein RarA QF06_11965 ENOG4105CUZ uba thif-type nad fad binding protein QF06_11970 ENOG4105C9M aspartyl-trna synthetase QF06_11975 ENOG4105CUT histidyl-tRNA synthetase QF06_11980 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase QF06_11990 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) QF06_11995 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) QF06_12000 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) QF06_12005 ENOG41067VP Protein of unknown function (DUF1049) QF06_12010 ENOG4105NCW Trka-c domain protein QF06_12015 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) QF06_12025 ENOG4105CKP Polysaccharide Biosynthesis Protein QF06_12030 ENOG4108QG2 Membrane QF06_12035 ENOG4105NAP QF06_12040 ENOG4105VIE preprotein translocase, subunit YajC QF06_12045 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) QF06_12050 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) QF06_12055 ENOG41061AI Protein of unknown function (DUF2905) QF06_12060 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) QF06_12065 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) QF06_12075 ENOG4105IE8 Alpha-ketoglutarate permease QF06_12080 ENOG4105CK5 oxidoreductase QF06_12100 ENOG4105BZG amino acid carrier protein QF06_12105 ENOG4105CDY transcriptional regulatory protein QF06_12115 ENOG4106678 morphogenetic protein associated with SpoVID QF06_12120 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) QF06_12125 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase QF06_12130 ENOG4108IYU L-aspartate oxidase QF06_12145 ENOG4105CQC Prephenate dehydratase QF06_12150 ENOG41090I5 UPF0735 ACT domain-containing protein QF06_12155 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control QF06_12165 ENOG4105K46 50S ribosomal protein l27 QF06_12170 ENOG4105X36 (ribosomal) protein QF06_12175 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) QF06_12190 ENOG4107QMS site-determining protein QF06_12195 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) QF06_12200 ENOG4105YHC Rod shape-determining protein MreD QF06_12205 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) QF06_12210 ENOG4105DFF Rod shape-determining protein mreb QF06_12215 ENOG4105W5Q DNA repair protein (RadC QF06_12220 ENOG4108Z03 MAF-like protein QF06_12230 ENOG4106A3R peptidase QF06_12235 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase QF06_12240 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) QF06_12250 ENOG4106AR7 Spore coat protein QF06_12255 ENOG41068KH stage VI sporulation protein D QF06_12260 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase QF06_12265 ENOG4105D52 delta-aminolevulinic acid dehydratase QF06_12275 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) QF06_12285 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) QF06_12295 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) QF06_12300 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) QF06_12305 ENOG4108IUQ atp-dependent protease QF06_12310 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) QF06_12315 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation QF06_12325 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) QF06_12330 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) QF06_12335 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) QF06_12340 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) QF06_12345 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase QF06_12350 ENOG4108ZP8 Acetolactate synthase small subunit QF06_12355 ENOG4105C7K acetolactate synthase QF06_12365 ENOG4105I4A GCN5-related N-acetyltransferase QF06_12370 ENOG4107KM7 Heat induced stress protein YflT QF06_12380 ENOG4105M59 Phosphodiesterase, mj0936 family QF06_12385 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) QF06_12390 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) QF06_12395 ENOG4108XJQ germination protein QF06_12400 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) QF06_12405 ENOG41067TZ transcriptional regulator, MarR family QF06_12410 ENOG4105PFC Transcriptional regulator QF06_12420 ENOG4105E33 succinate dehydrogenase QF06_12430 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit QF06_12440 ENOG4105CFH Aspartokinase QF06_12445 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) QF06_12450 ENOG4105K63 Thioredoxin QF06_12455 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) QF06_12460 ENOG4105C10 Electron transfer flavoprotein QF06_12465 ENOG4105BZJ Electron transfer flavoprotein QF06_12470 ENOG41060WC Enoyl-CoA hydratase QF06_12475 ENOG4107Z3H Transcriptional regulator, TetR family QF06_12480 ENOG4105CEY Amp-dependent synthetase and ligase QF06_12490 ENOG4105C98 muts2 protein QF06_12495 ENOG4105DCG PHP domain protein QF06_12510 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) QF06_12515 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) QF06_12520 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) QF06_12530 ENOG4108RWN rrna methyltransferase QF06_12535 ENOG41067MF small acid-soluble spore protein QF06_12545 ENOG4105CQB FAD linked oxidase domain protein QF06_12550 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) QF06_12565 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) QF06_12570 ENOG4105DRS transport system, permease QF06_12585 ENOG4108MDK Dehydrogenase QF06_12595 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase QF06_12600 ENOG4105EF1 ribulokinase QF06_12610 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase QF06_12615 ENOG4105CN9 Peptidase m42 family protein QF06_12625 ENOG410696E Membrane QF06_12630 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) QF06_12635 ENOG4105VJV 50s ribosomal protein L35 QF06_12640 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) QF06_12650 ENOG41067MG lrgb family QF06_12660 ENOG4105DY9 regulatoR QF06_12665 ENOG4108HRK Histidine kinase QF06_12670 ENOG4105U0R haloacid dehalogenase-like hydrolase QF06_12675 ENOG4105C22 threonyL-tRNA synthetase QF06_12680 ENOG4108TDW sporulation protein YtxC QF06_12700 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) QF06_12705 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) QF06_12710 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase QF06_12715 ENOG4105KVH Transcriptional regulator QF06_12720 ENOG4105F27 Major Facilitator QF06_12725 ENOG4105CV8 reductase QF06_12730 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) QF06_12740 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) QF06_12745 ENOG4105C2M dna polymerase I QF06_12750 ENOG4105BZU Histidine kinase QF06_12755 ENOG4105DPZ Two component transcriptional regulator (Winged helix family QF06_12760 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) QF06_12765 ENOG4108HMX isocitrate dehydrogenase (NADP) QF06_12770 ENOG4105BZN citrate synthase QF06_12780 ENOG4108REF Sporulation integral membrane protein ytvi QF06_12785 ENOG4105FS0 cytoplasmic membrane protein QF06_12790 ENOG4105CA9 Pyruvate kinase QF06_12795 ENOG4105CTQ phosphohexokinase QF06_12805 ENOG4108IEY Carboxyl transferase domain QF06_12810 ENOG4105C6K Malic enzyme QF06_12815 ENOG4105C0B DNA polymerase III (alpha subunit) QF06_12820 ENOG4105VV2 QF06_12830 ENOG4106EVM QF06_12835 ENOG4105SFS phosphoesterase RecJ domain protein QF06_12850 ENOG410635A Membrane QF06_12855 ENOG4105CH2 amidohydrolase QF06_12875 ENOG4105DEN Luciferase family QF06_12880 ENOG4105CDA abc transporter atp-binding protein QF06_12905 ENOG4108XSB acetyltransferase, (GNAT) family QF06_12910 ENOG4108KSA LysR family transcriptional regulator QF06_12915 ENOG4105E8R UPF0173 metal-dependent hydrolase QF06_12925 ENOG4105CH7 arginosuccinase QF06_12930 ENOG4105CDH Citrulline--aspartate ligase QF06_12935 ENOG4105EPU Molybdenum cofactor synthesis domain protein QF06_12940 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) QF06_12950 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) QF06_12955 ENOG4105KBJ sporulation protein ytfj QF06_12965 ENOG4105VK3 rdd domain containing protein QF06_12970 ENOG4105D07 Signal peptide peptidase, SppA QF06_12975 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) QF06_12980 ENOG4105EFZ amidohydrolase QF06_12985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) QF06_13020 ENOG4105U5Y Transcriptional regulator QF06_13030 ENOG4105BZU Histidine kinase QF06_13035 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) QF06_13040 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) QF06_13050 ENOG4105F1V Acetoin utilization protein QF06_13055 ENOG4105W87 Cbs domain QF06_13060 ENOG4105DGU Histone deacetylase QF06_13065 ENOG4105ER2 Ompa motb domain protein QF06_13070 ENOG4107R0U MotA TolQ exbB proton channel QF06_13075 ENOG4105ETE Transcriptional regulator (LacI family QF06_13080 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase QF06_13100 ENOG4105DFU Cell wall formation (By similarity) QF06_13110 ENOG4108VDD TRNA binding domain protein QF06_13125 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ QF06_13140 ENOG4105C6K Malic enzyme QF06_13145 ENOG4105C8F Beta-lactamase domain protein QF06_13150 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) QF06_13160 ENOG4108V15 phosphotransferase enzyme family QF06_13165 ENOG4108IUM Glycogen debranching enzyme QF06_13180 ENOG4107F58 2'-5' rna ligase QF06_13185 ENOG4105C6T cysteine synthase QF06_13190 ENOG4107QSE Dipeptidase QF06_13195 ENOG4105C7N Xanthine uracil vitamin C permease QF06_13210 ENOG4105YW5 deoR family transcriptional regulator QF06_13225 ENOG4105CBX hi0933 family QF06_13230 ENOG4105C94 Transporter QF06_13240 ENOG4105MU9 integral membrane protein QF06_13245 ENOG4105DDC Oxidoreductase domain protein QF06_13255 ENOG4105F5H Glycosyl Hydrolase Family 88 QF06_13265 ENOG41075H3 AraC family transcriptional regulator QF06_13275 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component QF06_13285 ENOG4106A3M Cytochrome p-450 QF06_13290 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) QF06_13300 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) QF06_13305 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) QF06_13315 ENOG4105NTD Inherit from COG: Hydrolase QF06_13330 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component QF06_13335 ENOG4105I1K ABC transporter QF06_13345 ENOG41085GJ domain protein QF06_13350 ENOG4105C8T Leucyl-tRNA synthetase QF06_13360 ENOG4105BZU Histidine kinase QF06_13365 ENOG410605W Major Facilitator QF06_13370 ENOG4106UBQ QF06_13380 ENOG4105C19 ABC transporter QF06_13385 ENOG4105EWM Histidine kinase QF06_13395 ENOG4107R34 abc transporter permease protein QF06_13400 ENOG4105C19 ABC transporter QF06_13415 ENOG4105DVE abc transporter atp-binding protein QF06_13420 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family QF06_13430 ENOG4105N5T Radical SAM Protein QF06_13445 ENOG4105E8V Alpha Beta Hydrolase Fold protein QF06_13450 ENOG4108Z0R Transferase QF06_13455 ENOG4105C85 amino acid QF06_13460 ENOG4105CAQ asparagine synthetase QF06_13465 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP QF06_13470 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase QF06_13485 ENOG4105D2X ABC transporter substrate-binding protein QF06_13495 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component QF06_13510 ENOG4108RMU ferritin dps family protein QF06_13525 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) QF06_13530 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) QF06_13535 ENOG4108V2W Carbonate dehydratase QF06_13555 ENOG4105CC5 ABC transporter QF06_13560 ENOG4105CC5 ABC transporter QF06_13565 ENOG4105DIK (ABC) transporter QF06_13570 ENOG4105DSE periplasmic solute binding protein QF06_13575 ENOG4105DTQ mandelate racemase muconate lactonizing QF06_13580 ENOG4105CEY Amp-dependent synthetase and ligase QF06_13585 ENOG4108IPT Naphthoate synthase QF06_13590 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) QF06_13595 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) QF06_13600 ENOG4105E4F Isochorismate synthase QF06_13620 ENOG4108IAJ Nad-dependent epimerase dehydratase QF06_13625 ENOG4107SBE Glycosyl transferase (Group 1 QF06_13640 ENOG4107SBE Glycosyl transferase (Group 1 QF06_13645 ENOG4108KS4 Spore coat protein QF06_13660 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) QF06_13670 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) QF06_13800 ENOG4105N67 Proton-coupled thiamine transporter YuaJ QF06_13805 ENOG4105VRR gCN5-related N-acetyltransferase QF06_13810 ENOG4105DZ6 Band 7 protein QF06_13820 ENOG4106DF1 QF06_13825 ENOG4108VNY MOSC domain protein QF06_13830 ENOG4108JB8 alcohol dehydrogenase QF06_13835 ENOG4105C26 Dehydrogenase QF06_13840 ENOG4105TRT Transcriptional regulator QF06_13855 ENOG4105CZN Potassium uptake protein QF06_13860 ENOG4107I77 yiaA/B two helix domain QF06_13865 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj QF06_13885 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) QF06_13895 ENOG4105EE0 oxidoreductase QF06_13900 ENOG4105DKG l-rhamnose isomerase QF06_13905 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) QF06_13910 ENOG4105DET Rhamnulokinase QF06_13915 ENOG4105E98 transcriptional regulator DeoR family QF06_13925 ENOG4105C8Q Methyl-accepting chemotaxis QF06_13930 ENOG4105C8Q Methyl-accepting chemotaxis QF06_13935 ENOG4105C8Q Methyl-accepting chemotaxis QF06_13940 ENOG4105C8Q Methyl-accepting chemotaxis QF06_13955 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme QF06_13965 ENOG4105C37 (CBS) domain QF06_13980 ENOG4107PBV potassium channel QF06_13985 ENOG4107PBV potassium channel QF06_14000 ENOG4107QYV phosphohexose isomerase QF06_14010 ENOG4107QW4 alcohol dehydrogenase QF06_14015 ENOG4105WG9 Conserved Protein QF06_14025 ENOG4105CHM Aminotransferase QF06_14030 ENOG4108ZB6 transcriptional regulator AsnC family QF06_14035 ENOG4108MUZ hydrolase QF06_14045 ENOG4105C87 Aminotransferase class I and II QF06_14050 ENOG4108HGU Histidine kinase QF06_14055 ENOG4105Y38 Kinase-associated protein B QF06_14075 ENOG4105BZ4 penicillin-binding protein QF06_14080 ENOG4105KIR Thiol-disulfide oxidoreductase dcc QF06_14095 ENOG4108MRH transcriptional regulatory protein QF06_14100 ENOG4105DIH basic membrane QF06_14105 ENOG4108JQ9 ABC transporter QF06_14110 ENOG4105UIB (ABC) transporter QF06_14130 ENOG4105D65 subunit l QF06_14135 ENOG4105HC0 Na H antiporter QF06_14140 ENOG4108ZE9 Monovalent cation H antiporter subunit C QF06_14145 ENOG4108JPZ Monovalent cation H antiporter subunit D QF06_14150 ENOG4105SC1 monovalent cation H antiporter subunit E QF06_14160 ENOG4105KJM monovalent cation h antiporter subunit g QF06_14165 ENOG4105KA0 thioesterase Superfamily protein QF06_14175 ENOG4105BZU Histidine kinase QF06_14205 ENOG4105DAP Nicotinate phosphoribosyltransferase QF06_14230 ENOG4105C02 permease QF06_14250 ENOG410904N short-chain dehydrogenase reductase QF06_14285 ENOG4108K8K Transcriptional regulator QF06_14290 ENOG4105DCF alanine dehydrogenase QF06_14300 ENOG4105WQT MbtH domain protein QF06_14305 ENOG4105CEY Amp-dependent synthetase and ligase QF06_14310 ENOG4105WQI isochorismatase QF06_14315 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase QF06_14320 ENOG4105E4F Isochorismate synthase QF06_14325 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase QF06_14330 ENOG4105NIV Esterase QF06_14350 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) QF06_14360 ENOG41069ER domain protein QF06_14370 ENOG4105CEP NADH dehydrogenase QF06_14375 ENOG4105CAY ferredoxin--nadp reductase QF06_14390 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 QF06_14395 ENOG4108YX9 iron--sulfur cluster insertion protein erpA QF06_14410 ENOG4105ZKE UPF0349 protein QF06_14425 ENOG41083MR nifu domain-containing protein QF06_14430 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein QF06_14435 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) QF06_14440 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) QF06_14445 ENOG4105D6E homoserine dehydrogenase QF06_14455 ENOG4108W5N phosphatidylglycerophosphatase a QF06_14460 ENOG4105D4U had-superfamily hydrolase, subfamily iia QF06_14470 ENOG4105MMD transcriptional regulator QF06_14475 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) QF06_14480 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) QF06_14485 ENOG4105FAA peptidase M23 QF06_14490 ENOG4108YTE sporulation protein YunB QF06_14495 ENOG4105KZD Domain of unknown function (DUF1805) QF06_14500 ENOG4107R8B 5'-nucleotidase QF06_14510 ENOG4105I3N Conserved Protein QF06_14520 ENOG4105CD3 dihydroorotase QF06_14525 ENOG4105G9B Transcriptional regulator QF06_14540 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) QF06_14545 ENOG4105VT2 5-hydroxyisourate hydrolase QF06_14555 ENOG4107YV9 domain protein QF06_14560 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding QF06_14575 ENOG4105XRQ Xanthine dehydrogenase accessory factor QF06_14580 ENOG4105C5R Aminotransferase QF06_14590 ENOG4108K8S endonuclease I QF06_14595 ENOG4108IJ9 (ABC) transporter QF06_14600 ENOG4105FDP GntR family transcriptional regulator QF06_14605 ENOG4108KPW sugar kinase QF06_14610 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component QF06_14615 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component QF06_14620 ENOG4105XN3 extracellular solute-binding protein family 1 QF06_14625 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine QF06_14630 ENOG4105PKS Excinuclease abc c subunit domain protein QF06_14635 ENOG4107VFR oxidoreductase QF06_14650 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase QF06_14655 ENOG4105NPE arsR family transcriptional regulator QF06_14660 ENOG4105DIW FeS assembly protein SUFB QF06_14665 ENOG4108UNV SUF system FeS assembly protein, NifU family QF06_14670 ENOG4105C9B Cysteine desulfurase QF06_14675 ENOG4105JRK feS assembly protein SufD QF06_14680 ENOG4105C3K feS assembly ATPase SufC QF06_14690 ENOG4105D01 (LipO)protein QF06_14695 ENOG4108UMI ABC transporter, permease QF06_14700 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) QF06_14725 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) QF06_14730 ENOG41080E8 Transcriptional regulator, Spx MgsR family QF06_14735 ENOG4105C1G acyl-Coa dehydrogenase QF06_14740 ENOG4105CHU acetyl-coa acetyltransferase QF06_14765 ENOG41067TZ transcriptional regulator, MarR family QF06_14770 ENOG4105C0R drug resistance transporter emrb qaca subfamily QF06_14775 ENOG4105MDS 4-oxalocrotonate tautomerase QF06_14790 ENOG4105EGI Transcriptional regulator QF06_14800 ENOG4105E0A ABC, transporter QF06_14815 ENOG4105E1F short-chain dehydrogenase reductase QF06_14820 ENOG4105HUF DNA protection during starvation protein QF06_14825 ENOG4105C0H protease QF06_14835 ENOG4105F3H Histidine kinase QF06_14840 ENOG41067SE Tetr family transcriptional regulator QF06_14845 ENOG4105C9Q fumarate hydratase class II QF06_14870 ENOG4105WH1 Two component transcriptional regulator luxr family QF06_14875 ENOG4105ENE Histidine kinase QF06_14890 ENOG41087YS Phage shock protein A QF06_14905 ENOG4108WBT adenosyltransferase QF06_14910 ENOG4105E0A ABC, transporter QF06_14915 ENOG4105EHG Permease protein QF06_14920 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) QF06_14925 ENOG4105EWI Short-chain dehydrogenase reductase Sdr QF06_14930 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein QF06_14940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family QF06_14950 ENOG4106DF4 Sigma-70, region 4 QF06_14955 ENOG4105F0F Oxalate decarboxylase QF06_14965 ENOG4107RBB ABC transporter, permease QF06_14970 ENOG4105C19 ABC transporter QF06_14975 ENOG4108WMK Efflux transporter RND family MFP subunit QF06_14980 ENOG4105E0A ABC, transporter QF06_14985 ENOG4105EHG Permease protein QF06_14990 ENOG4105DQ5 transport system permease protein QF06_15005 ENOG4105D5Q Arginine ornithine antiporter QF06_15015 ENOG4107K5X Membrane-bound metal-dependent hydrolase QF06_15020 ENOG4107QZ2 Sulfatase QF06_15025 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family QF06_15030 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein QF06_15035 ENOG4105E0C molybdate abc transporter QF06_15050 ENOG4105EEQ Na H antiporter QF06_15055 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) QF06_15060 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) QF06_15065 ENOG4105EEM helicase QF06_15075 ENOG4105EN6 Membrane QF06_15085 ENOG4107ZQN disulfide bond QF06_15090 ENOG4105C59 p-type ATPase QF06_15095 ENOG4105C59 p-type ATPase QF06_15100 ENOG410681U heavy metal transport detoxification protein QF06_15105 ENOG4105VPX protein, conserved in bacteria QF06_15110 ENOG4105D9R oxidoreductase QF06_15115 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) QF06_15120 ENOG4105ME7 Membrane QF06_15125 ENOG4105RXJ QF06_15130 ENOG4105KPY Small multidrug resistance protein QF06_15135 ENOG4105KBX Transcriptional regulator, TetR family QF06_15140 ENOG4105EWI Short-chain dehydrogenase reductase Sdr QF06_15155 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) QF06_15160 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) QF06_15170 ENOG4105XZU Preprotein translocase, subunit SecG QF06_15195 ENOG4105KVH Transcriptional regulator QF06_15200 ENOG4105C8Q Methyl-accepting chemotaxis QF06_15225 ENOG4105DA5 (ABC) transporter QF06_15255 ENOG4105R40 Glycine betaine carnitine choline QF06_15260 ENOG4108HQR Glycine betaine QF06_15265 ENOG4105E90 ABC transporter QF06_15270 ENOG4108IJ8 ABC transporter QF06_15275 ENOG4107HG4 Transcriptional regulator QF06_15280 ENOG4105R40 Glycine betaine carnitine choline QF06_15285 ENOG4108HQR Glycine betaine QF06_15290 ENOG4105E90 ABC transporter QF06_15295 ENOG4108IJ8 ABC transporter QF06_15300 ENOG4107HG4 Transcriptional regulator QF06_15305 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein QF06_15310 ENOG4108QCI YvbH-like oligomerisation region QF06_15320 ENOG4105T65 Membrane-associated protein QF06_15325 ENOG4108W0I acetyltransferase QF06_15330 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) QF06_15335 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) QF06_15340 ENOG4105CP7 Triose-phosphate isomerase QF06_15345 ENOG4105BZA Phosphoglycerate kinase QF06_15350 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase QF06_15365 ENOG4105CMD Transcriptional regulator, GntR family QF06_15370 ENOG4105DEN Luciferase family QF06_15375 ENOG4105GZI Transcriptional regulator QF06_15380 ENOG4107RT3 EamA-like transporter family QF06_15390 ENOG4105VRS hydrolase family 18 QF06_15395 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) QF06_15400 ENOG4107QR9 Iron-sulfur cluster binding protein QF06_15405 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) QF06_15415 ENOG4105BZU Histidine kinase QF06_15420 ENOG4105KCT ABC transporter QF06_15425 ENOG4108M15 ABC transporter QF06_15430 ENOG4107R6F Alpha Beta Hydrolase Fold protein QF06_15435 ENOG4108MJI response regulator QF06_15450 ENOG4105EG2 ABC transporter, permease QF06_15460 ENOG4107FKK extracellular solute-binding protein family 1 QF06_15470 ENOG4105JXH GntR family transcriptional regulator QF06_15475 ENOG4105DAA L-lactate QF06_15480 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) QF06_15490 ENOG4108ZPC Polysaccharide pyruvyl transferase QF06_15495 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase QF06_15500 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family QF06_15505 ENOG4105D3Q Sugar transferase QF06_15515 ENOG4105K64 Glycosyl transferase, family 2 QF06_15525 ENOG4107QRS glycosyltransferase group 2 family protein QF06_15530 ENOG41068W6 Capsular polysaccharide biosynthesis protein QF06_15535 ENOG4108KMV Glycosyl transferase (Group 1 QF06_15540 ENOG4105K64 Glycosyl transferase, family 2 QF06_15545 ENOG4108PQP glycosyl transferase group 1 QF06_15555 ENOG4108QV3 biosynthesis protein QF06_15560 ENOG4105HTX biosynthesis protein QF06_15570 ENOG4105EBR Carboxylesterase QF06_15580 ENOG4105PY6 Phenolic acid decarboxylase QF06_15585 ENOG4105NI3 Protein of unknown function (DUF3237) QF06_15595 ENOG4105FQP Beta-lactamase QF06_15600 ENOG4105EDQ levansucrase EC 2.4.1.10 QF06_15605 ENOG4108HKT sucrose-6-phosphate hydrolase QF06_15610 ENOG4107QTZ amino acid QF06_15640 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) QF06_15645 ENOG4107URF beta-phospho-glucomutase QF06_15650 ENOG4105CG3 alpha amylase, catalytic region QF06_15665 ENOG4105EG2 ABC transporter, permease QF06_15670 ENOG4105D56 permease protein QF06_15675 ENOG4107FKK extracellular solute-binding protein family 1 QF06_15680 ENOG4108IUK alpha amylase, catalytic QF06_15685 ENOG4105FKQ transcriptional regulator QF06_15690 ENOG4108URH decarboxylase QF06_15695 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain QF06_15700 ENOG4105CHH sulfate transporter QF06_15705 ENOG4108V2W Carbonate dehydratase QF06_15710 ENOG4105C5I Dehydrogenase QF06_15720 ENOG4105C19 ABC transporter QF06_15725 ENOG4105EWM Histidine kinase QF06_15745 ENOG4107A6P QF06_15750 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase QF06_15755 ENOG4105KRI phosphocarrier protein (HPr QF06_15760 ENOG4105CIE May be required for sporulation (By similarity) QF06_15765 ENOG4105CHW UPF0052 protein QF06_15770 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) QF06_15775 ENOG4108Z4K mutator MutT protein QF06_15780 ENOG4105C3M thioredoxin reductase QF06_15795 ENOG4105BZ1 (ABC) transporter QF06_15805 ENOG4106FGC QF06_15815 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase QF06_15820 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) QF06_15825 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase QF06_15830 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) QF06_15835 ENOG4105ECC imidazole-glycerol-phosphate dehydratase QF06_15840 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) QF06_15845 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) QF06_15850 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) QF06_15860 ENOG4108E16 pectate lyase QF06_15865 ENOG4108S4C acetyltransferase QF06_15870 ENOG4107XGZ Hydrolase QF06_15875 ENOG4105HKU nucleoside recognition domain-containing protein QF06_15880 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) QF06_15885 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) QF06_15890 ENOG4105CE4 GlcNAc 6-P deacetylase QF06_15895 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) QF06_15900 ENOG4105FDP GntR family transcriptional regulator QF06_15905 ENOG41088CQ domain protein QF06_15920 ENOG410625E QF06_15935 ENOG41086DT Membrane protein of unknown function QF06_15940 ENOG41067S9 phage shock protein C, PspC QF06_15945 ENOG4108PY7 QF06_15965 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) QF06_15970 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) QF06_15985 ENOG4105MKU Transcriptional regulator QF06_16005 ENOG4105CN1 protease QF06_16010 ENOG4105CRP Part of the ABC transporter FtsEX involved in QF06_16015 ENOG4105CAK Cell division ATP-binding protein ftsE QF06_16030 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) QF06_16040 ENOG4105MS2 ribosomal subunit Interface protein QF06_16055 ENOG4105MQ3 flagellar protein FliS QF06_16060 ENOG4107RT6 flagellar hook-associated QF06_16065 ENOG41083S7 flagellar protein FlaG QF06_16070 ENOG4105I03 Flagellin QF06_16075 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) QF06_16080 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) QF06_16085 ENOG4105MKD QF06_16090 ENOG4105DTJ flagellar hook-associated protein QF06_16095 ENOG4105E1Q flagellar hook-associated protein QF06_16110 ENOG4105RU3 QF06_16115 ENOG41081UC Inherit from COG: Competence protein QF06_16135 ENOG4105WH1 Two component transcriptional regulator luxr family QF06_16140 ENOG4105BZU Histidine kinase QF06_16145 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein QF06_16150 ENOG4108KGH TRANSCRIPTIONal QF06_16155 ENOG4105ESV Glycosyl transferase, family 4 QF06_16160 ENOG4107EF8 Glycosyl transferase (Group 1 QF06_16175 ENOG4105QZI O-Antigen Polymerase QF06_16180 ENOG4105C6Y Udp-glucose 6-dehydrogenase QF06_16185 ENOG4107RA4 Glycosyl transferase (Group 1 QF06_16190 ENOG4105PSV Polysaccharide Biosynthesis Protein QF06_16195 ENOG4105D3Q Sugar transferase QF06_16205 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase QF06_16210 ENOG4105JFG SpoIID LytB domain protein QF06_16225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase QF06_16245 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase QF06_16250 ENOG4105EY8 ABC transporter QF06_16260 ENOG4107VDP teichoic acid biosynthesis QF06_16265 ENOG41088M2 Glycosyl transferase family 2 QF06_16315 ENOG4105DG6 mannose-6-phosphate isomerase QF06_16330 ENOG4108NHD germination protein QF06_16335 ENOG4105C54 Major Facilitator superfamily QF06_16340 ENOG4108KGH TRANSCRIPTIONal QF06_16345 ENOG4105J7I hydrolase QF06_16350 ENOG4105K4H Nlp p60 protein QF06_16355 ENOG4105PNM synthesis protein QF06_16365 ENOG4105N98 Capsule biosynthesis protein capB QF06_16370 ENOG4105ETE Transcriptional regulator (LacI family QF06_16375 ENOG4108RVA ribokinase QF06_16380 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) QF06_16385 ENOG4105C2J ABC transporter QF06_16390 ENOG4105CNN ABC, transporter QF06_16395 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator QF06_16410 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein QF06_16415 ENOG4107FQX Alpha-acetolactate decarboxylase QF06_16425 ENOG4107RSM transcriptional regulator QF06_16440 ENOG4106UIA QF06_16455 ENOG4107XC4 flavin reductase domain protein, FMN-binding QF06_16465 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) QF06_16475 ENOG4105CAH Chromate QF06_16480 ENOG4105FGV Chromate QF06_16485 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) QF06_16510 ENOG4108XI2 Domain of unknown function (DUF1963) QF06_16515 ENOG4105C6Y Udp-glucose 6-dehydrogenase QF06_16520 ENOG4108RB3 Capsular polysaccharide biosynthesis protein QF06_16525 ENOG4107YJ4 chain length determinant protein QF06_16530 ENOG4105HTX biosynthesis protein QF06_16535 ENOG4105KBK Zinc finger, swim domain protein QF06_16540 ENOG4105C0D helicase QF06_16545 ENOG410667J hydrolase QF06_16550 ENOG4105E98 transcriptional regulator DeoR family QF06_16555 ENOG4105Z8H single-stranded DNA-binding protein QF06_16580 ENOG4108VAC response regulator QF06_16590 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) QF06_16595 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) QF06_16605 ENOG4105CGA flagellar basal-body rod protein FlgG QF06_16615 ENOG4105DFF Rod shape-determining protein mreb QF06_16620 ENOG4105MT0 Sporulation transcriptional regulator spoiiid QF06_16625 ENOG4107MII Sugar-specific transcriptional regulator TrmB QF06_16630 ENOG4105CZM Major Facilitator QF06_16635 ENOG4108M26 parallel beta-helix repeat protein QF06_16640 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease QF06_16645 ENOG41080V3 Major Facilitator superfamily QF06_16650 ENOG4105D3W isochorismatase QF06_16655 ENOG4107P26 QF06_16660 ENOG4105BZU Histidine kinase QF06_16670 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase QF06_16680 ENOG4105FRN stage II sporulation protein QF06_16685 ENOG4107TCE N-acetyltransferase QF06_16700 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) QF06_16705 ENOG4107TXC Transcriptional regulator QF06_16710 ENOG4106BRK QF06_16715 ENOG4108RYK Nad-dependent epimerase dehydratase QF06_16720 ENOG4108Z40 Transcriptional regulator QF06_16725 ENOG4105CQM Urea amidohydrolase subunit alpha QF06_16730 ENOG4105KI2 Urea amidohydrolase subunit beta QF06_16735 ENOG4108YZ9 Urea amidohydrolase subunit gamma QF06_16765 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) QF06_16770 ENOG4108TF4 von Willebrand factor, type A QF06_16785 ENOG4105JFG SpoIID LytB domain protein QF06_16790 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) QF06_16800 ENOG4106778 Protein of unknown function (DUF1146) QF06_16810 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) QF06_16815 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) QF06_16820 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) QF06_16825 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) QF06_16845 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) QF06_16855 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) QF06_16860 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) QF06_16865 ENOG4108UIC UPF0340 protein QF06_16870 ENOG4108YZG isomerase QF06_16875 ENOG4107WAU Protein tyrosine phosphatase QF06_16880 ENOG410815N Probably functions as a manganese efflux pump (By similarity) QF06_16885 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) QF06_16895 ENOG4108ZXQ stage ii sporulation protein r QF06_16910 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) QF06_16915 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) QF06_16920 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase QF06_16930 ENOG4107TT2 Auxin Efflux Carrier QF06_16935 ENOG4105C6K Malic enzyme QF06_16940 ENOG4107104 thymidine kinase QF06_16945 ENOG41082DI 50s ribosomal protein l31 QF06_16950 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) QF06_16955 ENOG4105CBT Fructose-1,6-bisphosphatase QF06_16960 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) QF06_16965 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway QF06_16970 ENOG4105D2N Aldolase QF06_16975 ENOG410812K response regulator receiver protein QF06_16985 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) QF06_16995 ENOG4105C1G acyl-Coa dehydrogenase QF06_17000 ENOG4105DF6 Fe-S oxidoreductase QF06_17010 ENOG4105E5J UV damage endonuclease QF06_17020 ENOG4105NAE bifunctional deaminase-reductase domain protein QF06_17025 ENOG4105BZ1 (ABC) transporter QF06_17030 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) QF06_17040 ENOG4105R3A Nitrate reductase QF06_17045 ENOG4108IUE nitrate reductase beta subunit QF06_17065 ENOG4107V6Q Cyclic nucleotide-binding domain QF06_17075 ENOG4105C75 arginyL-tRNA synthetase QF06_17080 ENOG410684U Domain of unknown function (DUF1934) QF06_17090 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E QF06_17140 ENOG4107JM4 Tetratricopeptide repeat QF06_17170 ENOG4108RDQ ABC transporter QF06_17180 ENOG4105CYW agmatinase QF06_17185 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) QF06_17190 ENOG4105BZ4 penicillin-binding protein QF06_17200 ENOG4108XFG YwhD family QF06_17205 ENOG4108Z4T Peptidase M50 QF06_17210 ENOG41069HH 4-oxalocrotonate tautomerase QF06_17215 ENOG41067TZ transcriptional regulator, MarR family QF06_17220 ENOG4105C22 threonyL-tRNA synthetase QF06_17225 ENOG4105C57 major facilitator superfamily QF06_17230 ENOG41062ES Transcriptional regulator QF06_17240 ENOG4105DCI Phosphohydrolase QF06_17250 ENOG4108VCI transcription factor, rsfa family QF06_17255 ENOG4108RNG Permease of the drug metabolite transporter QF06_17260 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) QF06_17265 ENOG4105DUM transcriptional regulator, lysR family QF06_17270 ENOG4108IJ2 phosphate acetyltransferase QF06_17285 ENOG4105CHM Aminotransferase QF06_17295 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase QF06_17300 ENOG4105CHR reductase QF06_17305 ENOG4106CHD Bacilysin biosynthesis protein bacB QF06_17310 ENOG41061WN bacilysin biosynthesis protein QF06_17315 ENOG4105FCW Major Facilitator superfamily QF06_17330 ENOG4105C26 Dehydrogenase QF06_17335 ENOG4105D82 Glutamate dehydrogenase QF06_17345 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase QF06_17350 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase QF06_17355 ENOG4105C1B dTDP-glucose 4-6-dehydratase QF06_17360 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) QF06_17365 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG QF06_17370 ENOG4107TY6 Acylneuraminate cytidylyltransferase QF06_17380 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD QF06_17385 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase QF06_17420 ENOG4105C26 Dehydrogenase QF06_17425 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) QF06_17430 ENOG4108RJ9 Glycosyl transferase, family 2 QF06_17450 ENOG4105DWF phosphomethylpyrimidine kinase QF06_17465 ENOG4105C5Y PTS System QF06_17470 ENOG4108QTI )-transporter QF06_17485 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin QF06_17490 ENOG4105DEN Luciferase family QF06_17495 ENOG4108DBC nitroreductase QF06_17510 ENOG41060D1 Quinol oxidase QF06_17515 ENOG4105CCU oxidase (Subunit III) QF06_17520 ENOG4105BZ9 Cytochrome C oxidase, subunit I QF06_17525 ENOG4105E2S oxidase) subunit II QF06_17530 ENOG4107BMA Transglycosylase associated protein QF06_17540 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) QF06_17545 ENOG4105WH5 Teichoic acid glycosylation protein QF06_17570 ENOG4107ZXU DSBA oxidoreductase QF06_17575 ENOG4105DBE peroxidase QF06_17580 ENOG410650H (LipO)protein QF06_17585 ENOG4107SJW iron permease, FTR1 QF06_17590 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) QF06_17600 ENOG4105CMU LysR family (Transcriptional regulator QF06_17605 ENOG4105VAW lrga family QF06_17610 ENOG41067MG lrgb family QF06_17615 ENOG4105D8G Major Facilitator superfamily QF06_17625 ENOG4105DR4 Methyltransferase QF06_17645 ENOG4105CK1 PTS System QF06_17650 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin QF06_17665 ENOG4105X1N Glycosyl transferase family 8 QF06_17675 ENOG4105GVJ transcriptional regulator QF06_17680 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) QF06_17685 ENOG4105IIU Aminopeptidase QF06_17710 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase QF06_17720 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) QF06_17725 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein QF06_17735 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD QF06_17740 ENOG4108VHC Short-chain dehydrogenase reductase Sdr QF06_17745 ENOG4105CM2 brancheD-chain amino acid aminotransferase QF06_17750 ENOG4105F8D glycoside hydrolase family 4 QF06_17755 ENOG4105VCP PTS System QF06_17760 ENOG4105CK1 PTS System QF06_17765 ENOG4105VZJ PTS System QF06_17770 ENOG4105EMD TRANSCRIPTIONal QF06_17775 ENOG4108VX5 3-methyladenine DNA glycosylase QF06_17780 ENOG4105CH6 catalase QF06_17795 ENOG4105DA5 (ABC) transporter QF06_17800 ENOG41069JR QF06_17820 ENOG4105ETS cytosine purines uracil thiamine allantoin QF06_17825 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) QF06_17830 ENOG4108JJ8 (ABC) transporter QF06_17835 ENOG4108JJ9 ABC, transporter QF06_17840 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii QF06_17845 ENOG4105C4M (Ubiquinol oxidase) subunit I QF06_17850 ENOG4105D2K citrate carrier protein QF06_17865 ENOG4107BJW polysaccharide deacetylase QF06_17895 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) QF06_17905 ENOG4105CMR udp-glucose 4-epimerase QF06_17910 ENOG4105KIS phospholipid-binding protein QF06_17915 ENOG4108WAV Transcriptional regulator QF06_17925 ENOG4105BZU Histidine kinase QF06_17930 ENOG4105WH1 Two component transcriptional regulator luxr family QF06_17935 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) QF06_17955 ENOG4105DTD Dehydrogenase QF06_17960 ENOG4108IIH CoA-transferase subunit B QF06_17965 ENOG4105D6N CoA-transferase, subunit a QF06_17970 ENOG4105CY2 Citrate transporter QF06_17975 ENOG4105DHI Methyltransferase QF06_17995 ENOG4105CH6 catalase QF06_18000 ENOG4105D4T Citrate transporter QF06_18005 ENOG4108RZ2 Glycoside hydrolase family 16 QF06_18010 ENOG4105CID antiterminator QF06_18020 ENOG4105DEU major facilitator superfamily QF06_18025 ENOG4105C1J atp-dependent rna helicase QF06_18030 ENOG4107TDE lipolytic protein G-D-S-L family QF06_18070 ENOG4105CNA YD repeat protein QF06_18080 ENOG4107YZX Universal stress protein QF06_18085 ENOG4105CS2 ec 3.2.1.21 QF06_18090 ENOG4105C5Y PTS System QF06_18135 ENOG4106Z5D Glycoside Hydrolase Family 43 QF06_18145 ENOG4105C84 Histidine ammonia-lyase QF06_18150 ENOG4105CGP Urocanate hydratase QF06_18155 ENOG4105CI2 imidazolone-5-propionate hydrolase QF06_18160 ENOG4107W25 arginase agmatinase formiminoglutamase QF06_18170 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) QF06_18175 ENOG4105D9N nucleoside QF06_18185 ENOG4107RHR regulatoR QF06_18190 ENOG4108TM9 integral membrane protein QF06_18195 ENOG4105ENY Ethanolamine utilization protein eutH QF06_18200 ENOG4108PGP mmge prpd family protein QF06_18205 ENOG4105CH2 amidohydrolase QF06_18215 ENOG4108HW4 amino acid AbC transporter QF06_18220 ENOG4105EAB amino acid AbC transporter QF06_18225 ENOG4108XSB acetyltransferase, (GNAT) family QF06_18230 ENOG4105CPU Monooxygenase QF06_18235 ENOG4107QHE Choloylglycine hydrolase QF06_18240 ENOG410667J hydrolase QF06_18270 ENOG4108V5C ABC transporter QF06_18300 ENOG4105D2N Aldolase QF06_18305 ENOG4107TRN Xylose isomerase domain protein TIM barrel QF06_18310 ENOG4105F0H myo-inositol catabolism protein QF06_18315 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) QF06_18325 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) QF06_18330 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) QF06_18335 ENOG4105D7K pfkb domain protein QF06_18345 ENOG4105C26 Dehydrogenase QF06_18355 ENOG4105CPC Aldo Keto reductase QF06_18370 ENOG4107QNK )-transporter QF06_18375 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) QF06_18385 ENOG41061TZ Short-chain dehydrogenase reductase Sdr QF06_18410 ENOG4105ST3 Transcriptional regulator QF06_18415 ENOG4105C26 Dehydrogenase QF06_18420 ENOG41085PJ rdd domain containing protein QF06_18425 ENOG4108ITS PQQ enzyme repeat QF06_18435 ENOG41085PJ rdd domain containing protein QF06_18450 ENOG4105J7D transcriptional regulator QF06_18455 ENOG4107JEE Short-chain dehydrogenase reductase Sdr QF06_18460 ENOG41061AU MarR family Transcriptional regulator QF06_18470 ENOG41067MG lrgb family QF06_18480 ENOG4105BZW Glycerate kinase QF06_18485 ENOG4105G3Z GntR family transcriptional regulator QF06_18490 ENOG4105CMG Carbohydrate kinase QF06_18495 ENOG4105C6Z Gluconate QF06_18500 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) QF06_18505 ENOG4105D3R alkyl hydroperoxide reductase QF06_18510 ENOG4108JU3 Alkyl hydroperoxide reductase QF06_18530 ENOG4108S3Y transcriptional regulator QF06_18540 ENOG4106KKU QF06_18545 ENOG4108Z15 abc transporter atp-binding protein QF06_18555 ENOG4105Y2Z radical SAM domain protein QF06_18565 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 QF06_18575 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) QF06_18585 ENOG4105E2A Dehydrogenase QF06_18605 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) QF06_18610 ENOG4105WQG acetyltransferase QF06_18615 ENOG410780I phosphoprotein phosphatase activity QF06_18625 ENOG41066UZ arginase EC 3.5.3.1 QF06_18630 ENOG4108IQI permease QF06_18635 ENOG4105C8Y Acetylornithine aminotransferase QF06_18640 ENOG4108JUB Transcriptional regulator QF06_18645 ENOG4105C0H protease QF06_18650 ENOG4105Q2H domain protein QF06_18665 ENOG4105BZU Histidine kinase QF06_18670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family QF06_18695 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis QF06_18700 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase QF06_18705 ENOG4105CDU Replicative dna helicase QF06_18720 ENOG4105DJ2 Major Facilitator Superfamily QF06_18725 ENOG4105EDW glycosyl transferase, family 39 QF06_18730 ENOG4105K9Q Binds to the 23S rRNA (By similarity) QF06_18735 ENOG4105BZR domain protein QF06_18740 ENOG4108XMW Membrane QF06_18755 ENOG4105KVH Transcriptional regulator QF06_18760 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase QF06_18780 ENOG41090E6 transcriptional regulator MERR family QF06_18800 ENOG4108U05 Transcriptional regulator QF06_18805 ENOG41082BV acetyltransferase QF06_18815 ENOG4108U7W acetyltransferase QF06_18820 ENOG4105UNS Pfam:DUF419 QF06_18825 ENOG4105NAE bifunctional deaminase-reductase domain protein QF06_18840 ENOG4108IPJ Membrane QF06_18845 ENOG4105C7Z Conserved Protein QF06_18850 ENOG4107FCW Abortive infection protein QF06_18860 ENOG4108UW5 maltose o-acetyltransferase QF06_18865 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase QF06_18875 ENOG4105CGK Exodeoxyribonuclease III QF06_18880 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) QF06_18885 ENOG4108UUM single-stranded DNA-binding protein QF06_18890 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) QF06_18895 ENOG4105C3G gtp-binding protein QF06_18900 ENOG4108J2R molybdopterin oxidoreductase QF06_18905 ENOG4105VDK protein, conserved in bacteria QF06_18915 ENOG4108ZDA Sporulation protein YyaC QF06_18920 ENOG4105FA0 parb-like partition protein QF06_18925 ENOG4107QJE Chromosome Partitioning Protein QF06_18940 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) QF06_18945 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) QF06_18950 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) QF06_18965 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) QF06_18975 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) QF06_18980 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) QF06_18985 ENOG410848D S4 domain protein YaaA QF06_19000 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) QF06_19005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) QF06_19030 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) QF06_19040 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) QF06_19045 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) QF06_19050 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) QF06_19060 ENOG4105ZMH deoxynucleoside kinase QF06_19070 ENOG4105VRS hydrolase family 18 QF06_19075 ENOG4105GTG Isochorismatase QF06_19080 ENOG4108Z6B deaminase QF06_19085 ENOG4105C6E dna polymerase iii QF06_19090 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) QF06_19095 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) QF06_19105 ENOG41067KS pro-sigma K processing QF06_19135 ENOG4105CDW Resistance protein QF06_19140 ENOG4105CXN decarboxylase QF06_19145 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) QF06_19150 ENOG4105X0R protein from nitrogen regulatory protein P-II QF06_19155 ENOG4105XVJ Protein of unknown function (DUF327) QF06_19160 ENOG4105FA2 dna polymerase iii QF06_19165 ENOG4105MA4 psp1 domain protein QF06_19170 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) QF06_19175 ENOG41060K3 Methyltransferase QF06_19180 ENOG4105VC4 domain protein QF06_19185 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) QF06_19190 ENOG4105KRN Transcriptional regulator, abrb family QF06_19195 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) QF06_19200 ENOG4105F8V Hydrolase, tatD family QF06_19205 ENOG41069ER domain protein QF06_19215 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) QF06_19220 ENOG4105XFA sporulation peptidase YabG QF06_19225 ENOG4105W42 Veg protein QF06_19230 ENOG4105XEW small acid-soluble spore protein QF06_19235 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) QF06_19240 ENOG4105DFT pur operon repressor QF06_19245 ENOG4105KME endoribonuclease L-psp QF06_19250 ENOG4105K4W Could be involved in septation (By similarity) QF06_19255 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) QF06_19260 ENOG4105C5T Phosphoribosyl pyrophosphate synthase QF06_19265 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) QF06_19270 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) QF06_19280 ENOG4108JA2 transcriptioN-repair coupling factor QF06_19285 ENOG4108M14 stage v sporulation protein t QF06_19295 ENOG4108IY2 MazG family QF06_19300 ENOG41082I2 s4 domain protein QF06_19305 ENOG4105VYY sporulation protein yabp QF06_19320 ENOG41060GV RNA binding s1 domain protein QF06_19350 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) QF06_19355 ENOG4108UGV hypoxanthine phosphoribosyltransferase QF06_19360 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) QF06_19370 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) QF06_19375 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase QF06_19380 ENOG4105C6T cysteine synthase QF06_19385 ENOG4105CRQ synthase (Component I) QF06_19390 ENOG4105DDQ anthranilate synthase QF06_19395 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 QF06_19400 ENOG4105EEI dihydropteroate synthase QF06_19405 ENOG4105KRF dihydroneopterin aldolase QF06_19410 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase QF06_19420 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) QF06_19425 ENOG4105CRK lysyL-tRNA synthetase QF06_19495 ENOG4108Z0C Uvrb UvrC protein QF06_19500 ENOG41066A3 ATP guanido phosphotransferase QF06_19510 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) QF06_19515 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) QF06_19520 ENOG4105CTP PilT protein domain protein QF06_19525 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) QF06_19530 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) QF06_19535 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) QF06_19545 ENOG4105D7W serine acetyltransferase QF06_19550 ENOG4105C8N cysteinyl-tRNA synthetase QF06_19555 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) QF06_19560 ENOG4105C2N RNA methyltransferase TrmH family group 3 QF06_19565 ENOG4105M0M Tetracycline resistance protein QF06_19580 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) QF06_19585 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) QF06_19595 ENOG4108VZM 50s ribosomal protein L10 QF06_19600 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) QF06_19605 ENOG4107Y49 methyltransferase QF06_19610 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) QF06_19615 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) QF06_19620 ENOG4105XPM ribosomal protein QF06_19625 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) QF06_19630 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) QF06_19635 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) QF06_19640 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) QF06_19645 ENOG4107SKW Inherit from COG: Alpha beta hydrolase QF06_19650 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) QF06_19655 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) QF06_19660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) QF06_19665 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) QF06_19670 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity QF06_19675 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) QF06_19680 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) QF06_19685 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) QF06_19690 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) QF06_19695 ENOG41082SA 50s ribosomal protein l29 QF06_19700 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal QF06_19705 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) QF06_19715 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits QF06_19725 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) QF06_19730 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) QF06_19735 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) QF06_19740 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) QF06_19745 ENOG4105VPB 50S ribosomal protein L30 QF06_19750 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) QF06_19755 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) QF06_19765 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) QF06_19775 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) QF06_19785 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits QF06_19790 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) QF06_19795 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) QF06_19800 ENOG4108ZT0 50S ribosomal protein l17 QF06_19805 ENOG4108JJB ABC transporter QF06_19810 ENOG4108JJB ABC transporter QF06_19815 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) QF06_19820 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) QF06_19825 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) QF06_19830 ENOG4108UJD 30S ribosomal protein S9 QF06_19835 ENOG4108I0C methyltransferase QF06_19850 ENOG4105D1F ATP-binding protein QF06_19865 ENOG4108NMV polysaccharide deacetylase QF06_19975 ENOG4105CHH sulfate transporter QF06_19985 ENOG4108SA1 esterase QF06_20005 ENOG410874W AraC family transcriptional regulator QF06_20010 ENOG4105EHZ conserved protein UCP016719 QF06_20015 ENOG4105D17 glycoside hydrolase, family 3 domain protein QF06_20035 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate QF06_20045 ENOG4105EWC Purine nucleoside phosphorylase QF06_20075 ENOG4105EMN RNA polymerase sigma factor QF06_20085 ENOG4105C8B TIGR00159 family QF06_20090 ENOG4107U5W ybbr family QF06_20095 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) QF06_20100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) QF06_20105 ENOG4105D03 DNA-3-methyladenine glycosylase II QF06_20115 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) QF06_20120 ENOG4108TWJ NADH dehydrogenase subunit 5 QF06_20140 ENOG4105GPN Uncharacterized conserved protein (DUF2294) QF06_20145 ENOG4105WAB arsR family transcriptional regulator QF06_20150 ENOG4108RWP Major Facilitator Superfamily protein QF06_20165 ENOG4105G0J serine threonine protein kinase QF06_20175 ENOG4106K80 QF06_20185 ENOG4106DDH Sporulation-specific SASP protein QF06_20195 ENOG4108HWY Beta-lactamase QF06_20500 ENOG41088HM QF06_20505 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) QF06_20510 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) QF06_20515 ENOG4105NQC Flavodoxin QF06_20590 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) QF06_20610 ENOG4106J9J DNA polymerase QF06_20630 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) QF06_20675 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)