locus-tag	class	description
QF06_00005	COG2124	cytochrome p450
QF06_00015	COG0531	amino acid
QF06_00020	COG0584	glycerophosphoryl diester phosphodiesterase
QF06_00035	COG1846	Transcriptional regulator
QF06_00035	COG0456	acetyltransferase
QF06_00040	COG2271	Major facilitator Superfamily
QF06_00050	COG3409	Peptidoglycan-binding domain 1 protein
QF06_00055	COG0697	spore germination
QF06_00060	COG2207	Transcriptional regulator
QF06_00060	COG1917	Cupin 2, conserved barrel domain protein
QF06_00065	COG1397	ADP-ribosylglycohydrolase
QF06_00070	COG5444	nuclease activity
QF06_00075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
QF06_00080	COG3591	Belongs to the peptidase S1B family
QF06_00090	COG0596	Alpha beta hydrolase
QF06_00095	COG1183	phosphatidylcholine synthase activity
QF06_00100	COG0586	Pfam SNARE associated Golgi protein
QF06_00105	COG0688	phosphatidylethanolamine metabolic process
QF06_00115	COG2312	Erythromycin esterase
QF06_00125	COG1301	dicarboxylic acid transport
QF06_00130	COG2190	(PTS) system
QF06_00130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_00130	COG1263	PTS System
QF06_00135	COG0363	glucosamine-6-phosphate deaminase activity
QF06_00145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QF06_00150	COG0833	amino acid
QF06_00155	COG2040	homocysteine
QF06_00165	COG1115	amino acid carrier protein
QF06_00170	COG2066	Belongs to the glutaminase family
QF06_00175	COG4191	Histidine kinase
QF06_00180	COG0784	Response regulator, receiver
QF06_00185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
QF06_00190	COG1012	belongs to the aldehyde dehydrogenase family
QF06_00195	COG2271	Major facilitator Superfamily
QF06_00200	COG4948	Mandelate Racemase Muconate Lactonizing
QF06_00205	COG2186	Transcriptional regulator
QF06_00210	COG2721	sulfolactate sulfo-lyase activity
QF06_00215	COG3173	Aminoglycoside phosphotransferase
QF06_00225	COG0697	spore germination
QF06_00230	COG0745	RESPONSE REGULATOR receiver
QF06_00235	COG2205	protein histidine kinase activity
QF06_00240	COG1131	(ABC) transporter
QF06_00255	COG3773	Cell wall hydrolase
QF06_00260	COG2304	oxidoreductase activity
QF06_00265	COG3540	Alkaline phosphatase
QF06_00270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
QF06_00275	COG0805	protein transport
QF06_00280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
QF06_00285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
QF06_00290	COG0477	Major facilitator Superfamily
QF06_00295	COG1309	transcriptional regulator
QF06_00300	COG0252	asparaginase activity
QF06_00305	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
QF06_00310	COG1714	RDD family
QF06_00315	COG3012	SEC-C Motif Domain Protein
QF06_00315	COG1405	negative regulation of cell septum assembly
QF06_00320	COG3290	protein histidine kinase activity
QF06_00325	COG3279	Response regulator of the LytR AlgR family
QF06_00330	COG4555	ABC transporter
QF06_00335	COG1668	transmembrane transport
QF06_00340	COG0667	Aldo Keto reductase
QF06_00350	COG1595	DNA-templated transcription, initiation
QF06_00355	COG1595	DNA-templated transcription, initiation
QF06_00360	COG1876	peptidase activity
QF06_00365	COG0457	Tetratricopeptide repeat
QF06_00370	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_00375	COG0366	Alpha amylase catalytic
QF06_00380	COG0803	Belongs to the bacterial solute-binding protein 9 family
QF06_00385	COG1121	(ABC) transporter
QF06_00390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
QF06_00395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QF06_00400	COG2310	stress, protein
QF06_00405	COG2310	stress, protein
QF06_00410	COG2310	stress, protein
QF06_00415	COG0861	Integral membrane protein TerC family
QF06_00425	COG3853	Toxic anion resistance protein (TelA)
QF06_00430	COG0477	Major facilitator Superfamily
QF06_00435	COG2814	Major facilitator Superfamily
QF06_00440	COG0640	Transcriptional regulator
QF06_00445	COG4175	Glycine betaine
QF06_00445	COG0517	IMP dehydrogenase activity
QF06_00450	COG4176	ABC-type proline glycine betaine transport system permease component
QF06_00455	COG2113	Glycine betaine
QF06_00460	COG1473	amidohydrolase
QF06_00465	COG1288	antiporter activity
QF06_00475	COG0366	Alpha amylase catalytic
QF06_00480	COG0039	L-malate dehydrogenase activity
QF06_00485	COG1620	l-lactate permease
QF06_00490	COG2814	Major facilitator Superfamily
QF06_00495	COG1846	Transcriptional regulator
QF06_00500	COG1280	lysine exporter protein (LysE YggA)
QF06_00505	COG3403	YqcI/YcgG family
QF06_00510	COG1113	amino acid transport
QF06_00515	COG3665	Urea carboxylase-associated protein
QF06_00520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
QF06_00525	COG1660	Displays ATPase and GTPase activities
QF06_00530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
QF06_00535	COG2226	methyltransferase
QF06_00540	COG0583	DNA-binding transcription factor activity
QF06_00545	COG3458	cephalosporin-C deacetylase activity
QF06_00550	COG3541	Predicted nucleotidyltransferase
QF06_00560	COG1012	belongs to the aldehyde dehydrogenase family
QF06_00565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QF06_00570	COG2508	Transcriptional regulator
QF06_00575	COG3689	TIGRFAM TIGR03943 family protein
QF06_00580	COG0701	Predicted permease
QF06_00585	COG2267	carboxylic ester hydrolase activity
QF06_00590	COG0492	ferredoxin-NADP+ reductase activity
QF06_00595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
QF06_00595	COG1587	Uroporphyrinogen-III synthase
QF06_00600	COG2146	nitrite reductase [NAD(P)H] activity
QF06_00605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
QF06_00610	COG0243	molybdopterin cofactor binding
QF06_00615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
QF06_00620	COG2223	nitrite transmembrane transporter activity
QF06_00625	COG1469	GTP cyclohydrolase I activity
QF06_00630	COG1376	ErfK ybiS ycfS ynhG family protein
QF06_00635	COG0523	cobalamin synthesis protein
QF06_00640	COG0765	amino acid transport
QF06_00645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QF06_00655	COG1714	RDD family
QF06_00665	COG2723	6-phospho-beta-galactosidase activity
QF06_00675	COG3209	COG3209 Rhs family protein
QF06_00680	COG0840	transmembrane signaling receptor activity
QF06_00680	COG3290	protein histidine kinase activity
QF06_00685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
QF06_00690	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
QF06_00695	COG1733	regulation of RNA biosynthetic process
QF06_00700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_00705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_00710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_00715	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
QF06_00720	COG2814	Major facilitator Superfamily
QF06_00730	COG0697	spore germination
QF06_00735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QF06_00745	COG2364	Membrane
QF06_00750	COG1126	abc transporter atp-binding protein
QF06_00755	COG0765	amino acid transport
QF06_00760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QF06_00765	COG0583	DNA-binding transcription factor activity
QF06_00770	COG0163	prenyltransferase activity
QF06_00775	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
QF06_00790	COG0596	Alpha beta hydrolase
QF06_00795	COG3104	oligopeptide transport
QF06_00800	COG5434	Belongs to the glycosyl hydrolase 28 family
QF06_00810	COG0697	spore germination
QF06_00820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
QF06_00825	COG1136	(ABC) transporter
QF06_00830	COG0577	efflux transmembrane transporter activity
QF06_00835	COG0745	RESPONSE REGULATOR receiver
QF06_00840	COG5002	protein histidine kinase activity
QF06_00840	COG3850	Histidine kinase
QF06_00845	COG0457	Tetratricopeptide repeat
QF06_00865	COG0527	aspartate kinase activity
QF06_00870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_00875	COG4605	iron ion homeostasis
QF06_00880	COG4604	ABC transporter, ATP-binding protein
QF06_00885	COG4607	ABC-type enterochelin transport system periplasmic component
QF06_00890	COG2814	Major facilitator Superfamily
QF06_00895	COG1309	transcriptional regulator
QF06_00900	COG0778	Nitroreductase
QF06_00905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
QF06_00910	COG0640	Transcriptional regulator
QF06_00915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QF06_00920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
QF06_00925	COG1012	belongs to the aldehyde dehydrogenase family
QF06_00930	COG4975	Glucose uptake
QF06_00935	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_00940	COG4549	nuclear export factor GLE1
QF06_00945	COG2372	response to copper ion
QF06_00945	COG1276	copper resistance
QF06_00950	COG1349	DNA-binding transcription factor activity
QF06_00960	COG2213	PTS system mannitol-specific
QF06_00965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_00970	COG0246	Mannitol dehydrogenase
QF06_00975	COG0473	3-isopropylmalate dehydrogenase activity
QF06_00980	COG0681	Belongs to the peptidase S26 family
QF06_00985	COG0412	Dienelactone hydrolase
QF06_00990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
QF06_00995	COG0561	phosphatase activity
QF06_01000	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
QF06_01005	COG1914	H( )-stimulated, divalent metal cation uptake system
QF06_01010	COG4336	lyase activity
QF06_01015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
QF06_01020	COG1984	allophanate hydrolase subunit 2
QF06_01025	COG1414	Transcriptional regulator
QF06_01030	COG2755	lipolytic protein G-D-S-L family
QF06_01040	COG2329	Antibiotic biosynthesis monooxygenase
QF06_01045	COG0768	penicillin binding
QF06_01050	COG4989	oxidoreductase activity
QF06_01055	COG3711	transcriptional antiterminator
QF06_01060	COG0318	PFAM AMP-dependent synthetase and ligase
QF06_01065	COG2226	methyltransferase
QF06_01070	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_01075	COG1917	Cupin 2, conserved barrel domain protein
QF06_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_01085	COG3871	stress protein (general stress protein 26)
QF06_01095	COG2814	Major facilitator Superfamily
QF06_01100	COG1522	sequence-specific DNA binding
QF06_01105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
QF06_01105	COG0551	DNA topoisomerase type I activity
QF06_01110	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
QF06_01115	COG3706	GGDEF domain
QF06_01120	COG5298	Protein conserved in bacteria
QF06_01125	COG1215	transferase activity, transferring glycosyl groups
QF06_01135	COG0531	amino acid
QF06_01140	COG0494	nUDIX hydrolase
QF06_01145	COG0028	Belongs to the TPP enzyme family
QF06_01155	COG1914	H( )-stimulated, divalent metal cation uptake system
QF06_01160	COG2261	transglycosylase associated protein
QF06_01165	COG4876	unkown
QF06_01170	COG2217	Heavy metal translocating P-type atpase
QF06_01175	COG3729	General stress protein
QF06_01180	COG0662	Cupin 2, conserved barrel domain protein
QF06_01185	COG2329	Antibiotic biosynthesis monooxygenase
QF06_01190	COG3546	catalase activity
QF06_01195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
QF06_01200	COG3290	protein histidine kinase activity
QF06_01205	COG4565	transcriptional regulatory protein
QF06_01210	COG1301	dicarboxylic acid transport
QF06_01215	COG0628	permease
QF06_01220	COG1131	(ABC) transporter
QF06_01225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
QF06_01235	COG1960	acyl-CoA dehydrogenase activity
QF06_01240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
QF06_01245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_01250	COG1181	Belongs to the D-alanine--D-alanine ligase family
QF06_01255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
QF06_01260	COG0513	Belongs to the DEAD box helicase family
QF06_01265	COG3402	PFAM membrane-flanked domain
QF06_01270	COG3428	Bacterial PH domain
QF06_01275	COG0705	Rhomboid family
QF06_01280	COG0736	holo-[acyl-carrier-protein] synthase activity
QF06_01285	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
QF06_01290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
QF06_01295	COG0864	Transcriptional regulator
QF06_01300	COG2337	Toxic component of a toxin-antitoxin (TA) module
QF06_01305	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_01310	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_01315	COG2172	sigma factor antagonist activity
QF06_01320	COG2208	phosphoserine phosphatase activity
QF06_01325	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_01330	COG2172	sigma factor antagonist activity
QF06_01335	COG1191	sigma factor activity
QF06_01340	COG2208	phosphoserine phosphatase activity
QF06_01345	COG2183	response to ionizing radiation
QF06_01350	COG3091	SprT-like family
QF06_01390	COG0582	viral genome integration into host DNA
QF06_01405	COG0457	Tetratricopeptide repeat
QF06_01425	COG5444	nuclease activity
QF06_01435	COG1476	TRANSCRIPTIONal
QF06_01445	COG3239	Fatty acid desaturase
QF06_01450	COG1278	Cold shock
QF06_01455	COG1329	Transcriptional regulator
QF06_01460	COG0697	spore germination
QF06_01465	COG1917	Cupin 2, conserved barrel domain protein
QF06_01465	COG2207	Transcriptional regulator
QF06_01470	COG0697	spore germination
QF06_01475	COG3708	Transcriptional regulator
QF06_01475	COG2207	Transcriptional regulator
QF06_01480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QF06_01485	COG0477	Major facilitator Superfamily
QF06_01495	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
QF06_01510	COG1309	transcriptional regulator
QF06_01515	COG0697	spore germination
QF06_01520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QF06_01525	COG2030	dehydratase
QF06_01530	COG3545	Serine hydrolase
QF06_01535	COG1733	regulation of RNA biosynthetic process
QF06_01540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QF06_01545	COG1733	regulation of RNA biosynthetic process
QF06_01550	COG2249	NAD(P)H dehydrogenase (quinone) activity
QF06_01555	COG2814	Major facilitator Superfamily
QF06_01560	COG1309	transcriptional regulator
QF06_01565	COG0640	Transcriptional regulator
QF06_01570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
QF06_01575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_01580	COG0697	spore germination
QF06_01585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QF06_01590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
QF06_01595	COG0640	Transcriptional regulator
QF06_01600	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
QF06_01610	COG4585	Histidine kinase
QF06_01615	COG2197	response regulator
QF06_01620	COG2409	Drug exporters of the RND superfamily
QF06_01625	COG0596	Alpha beta hydrolase
QF06_01630	COG1811	Na channel or pump
QF06_01635	COG0789	Transcriptional regulator
QF06_01635	COG4978	Transcriptional regulator
QF06_01640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
QF06_01645	COG0778	Nitroreductase
QF06_01650	COG0346	lactoylglutathione lyase activity
QF06_01655	COG2259	Doxx family
QF06_01660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_01685	COG2323	membrane
QF06_01690	COG2323	membrane
QF06_01695	COG0071	Belongs to the small heat shock protein (HSP20) family
QF06_01710	COG1309	transcriptional regulator
QF06_01720	COG0456	acetyltransferase
QF06_01730	COG1113	amino acid transport
QF06_01735	COG2318	DinB family
QF06_01740	COG1846	Transcriptional regulator
QF06_01745	COG2409	Drug exporters of the RND superfamily
QF06_01745	COG1033	growth of symbiont in host cell
QF06_01750	COG0778	Nitroreductase
QF06_01755	COG1846	Transcriptional regulator
QF06_01760	COG2814	Major facilitator Superfamily
QF06_01765	COG0730	response to heat
QF06_01770	COG1802	Transcriptional regulator
QF06_01775	COG1388	LysM domain
QF06_01775	COG3858	chitin binding
QF06_01780	COG1819	glycosyl
QF06_01790	COG1785	Belongs to the alkaline phosphatase family
QF06_01795	COG5646	InterPro IPR014922
QF06_01805	COG0454	-acetyltransferase
QF06_01810	COG1078	dGTPase activity
QF06_01815	COG1388	LysM domain
QF06_01820	COG2814	Major facilitator Superfamily
QF06_01825	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QF06_01830	COG1447	Phosphotransferase system cellobiose-specific component IIA
QF06_01835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QF06_01840	COG2723	6-phospho-beta-galactosidase activity
QF06_01845	COG2188	Transcriptional regulator
QF06_01850	COG1940	carbohydrate kinase activity
QF06_01855	COG1482	cell wall glycoprotein biosynthetic process
QF06_01860	COG4124	Belongs to the glycosyl hydrolase 26 family
QF06_01905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
QF06_01910	COG0802	atpase or kinase
QF06_01915	COG1214	PFAM Peptidase M22, glycoprotease
QF06_01920	COG0456	acetyltransferase
QF06_01925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
QF06_01930	COG0488	(ABC) transporter
QF06_01935	COG0315	cyclic pyranopterin monophosphate synthase activity
QF06_01940	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
QF06_01945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
QF06_01950	COG0805	protein transport
QF06_01960	COG1266	CAAX protease self-immunity
QF06_01965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
QF06_01970	COG0459	protein refolding
QF06_01975	COG1073	alpha beta
QF06_01980	COG0457	Tetratricopeptide repeat
QF06_01985	COG1063	alcohol dehydrogenase
QF06_01990	COG2211	Major facilitator Superfamily
QF06_01995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
QF06_02000	COG1842	Phage shock protein A
QF06_02005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
QF06_02010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
QF06_02015	COG4260	virion core protein, lumpy skin disease virus
QF06_02025	COG2814	Major facilitator Superfamily
QF06_02030	COG1063	alcohol dehydrogenase
QF06_02035	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
QF06_02040	COG0823	Involved in the tonB-independent uptake of proteins
QF06_02055	COG2267	carboxylic ester hydrolase activity
QF06_02065	COG2132	Multicopper oxidase
QF06_02070	COG1113	amino acid transport
QF06_02075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
QF06_02080	COG0714	Associated with various cellular activities
QF06_02085	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
QF06_02090	COG1305	Transglutaminase-like
QF06_02095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
QF06_02095	COG0519	Catalyzes the synthesis of GMP from XMP
QF06_02110	COG2252	PERMEase
QF06_02115	COG3064	Membrane
QF06_02120	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
QF06_02130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
QF06_02135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
QF06_02140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
QF06_02145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
QF06_02150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
QF06_02155	COG0047	phosphoribosylformylglycinamidine synthase activity
QF06_02160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
QF06_02165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
QF06_02170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
QF06_02175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
QF06_02180	COG0138	bifunctional purine biosynthesis protein purh
QF06_02185	COG0151	Belongs to the GarS family
QF06_02190	COG1522	sequence-specific DNA binding
QF06_02195	COG0531	amino acid
QF06_02205	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
QF06_02210	COG1470	cell adhesion involved in biofilm formation
QF06_02215	COG4496	protein, YerC YecD
QF06_02220	COG0069	glutamate synthase activity
QF06_02225	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
QF06_02230	COG0210	DNA helicase
QF06_02235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
QF06_02240	COG4851	CamS sex pheromone cAM373 precursor
QF06_02245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QF06_02250	COG1285	pathogenesis
QF06_02255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QF06_02260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
QF06_02265	COG0154	amidase activity
QF06_02270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
QF06_02275	COG1309	transcriptional regulator
QF06_02280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
QF06_02285	COG1597	lipid kinase activity
QF06_02290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
QF06_02305	COG5444	nuclease activity
QF06_02310	COG3391	amine dehydrogenase activity
QF06_02315	COG0457	Tetratricopeptide repeat
QF06_02325	COG0217	transcriptional regulatory protein
QF06_02335	COG1309	transcriptional regulator
QF06_02340	COG3631	Ketosteroid isomerase-related protein
QF06_02345	COG0702	epimerase
QF06_02360	COG3546	catalase activity
QF06_02365	COG0454	-acetyltransferase
QF06_02375	COG5578	integral membrane protein
QF06_02380	COG2972	Histidine kinase
QF06_02385	COG4753	response regulator
QF06_02385	COG2207	Transcriptional regulator
QF06_02390	COG1653	transport
QF06_02395	COG1175	transmembrane transport
QF06_02400	COG0395	ABC-type sugar transport system, permease component
QF06_02405	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
QF06_02410	COG2207	Transcriptional regulator
QF06_02415	COG2755	lipolytic protein G-D-S-L family
QF06_02425	COG5578	integral membrane protein
QF06_02430	COG3401	FG-GAP repeat protein
QF06_02435	COG3401	FG-GAP repeat protein
QF06_02440	COG2755	lipolytic protein G-D-S-L family
QF06_02445	COG1874	Beta-galactosidase
QF06_02455	COG1653	transport
QF06_02460	COG4209	transmembrane transport
QF06_02465	COG0395	ABC-type sugar transport system, permease component
QF06_02470	COG1486	melibiose metabolic process
QF06_02475	COG2323	membrane
QF06_02480	COG2329	Antibiotic biosynthesis monooxygenase
QF06_02485	COG0346	lactoylglutathione lyase activity
QF06_02500	COG0670	Belongs to the BI1 family
QF06_02505	COG0697	spore germination
QF06_02510	COG1846	Transcriptional regulator
QF06_02515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
QF06_02530	COG2124	cytochrome p450
QF06_02530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
QF06_02535	COG1368	sulfuric ester hydrolase activity
QF06_02540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
QF06_02545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
QF06_02550	COG1442	glycosyl transferase family 8
QF06_02555	COG1216	Glycosyl transferase, family 2
QF06_02560	COG1442	glycosyl transferase family 8
QF06_02565	COG2223	nitrite transmembrane transporter activity
QF06_02570	COG1011	Hydrolase
QF06_02575	COG0531	amino acid
QF06_02580	COG1012	belongs to the aldehyde dehydrogenase family
QF06_02585	COG0840	transmembrane signaling receptor activity
QF06_02590	COG0488	(ABC) transporter
QF06_02600	COG0789	Transcriptional regulator
QF06_02605	COG2814	Major facilitator Superfamily
QF06_02625	COG0488	(ABC) transporter
QF06_02630	COG0513	Belongs to the DEAD box helicase family
QF06_02635	COG0456	acetyltransferase
QF06_02640	COG2130	NADP-dependent
QF06_02645	COG1120	ATPase activity
QF06_02650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_02655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_02660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
QF06_02675	COG3866	Pectate lyase
QF06_02680	COG0471	metal ion transport
QF06_02685	COG3290	protein histidine kinase activity
QF06_02690	COG4565	transcriptional regulatory protein
QF06_02695	COG3181	Tripartite tricarboxylate transporter family receptor
QF06_02700	COG2851	Citrate transporter
QF06_02705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_02710	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
QF06_02715	COG1254	Belongs to the acylphosphatase family
QF06_02720	COG2258	MOSC domain
QF06_02730	COG0024	Methionine aminopeptidase
QF06_02735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_02735	COG1263	PTS System
QF06_02740	COG1368	sulfuric ester hydrolase activity
QF06_02750	COG1115	amino acid carrier protein
QF06_02755	COG0531	amino acid
QF06_02770	COG0697	spore germination
QF06_02775	COG1263	PTS System
QF06_02775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_02780	COG0366	Alpha amylase catalytic
QF06_02785	COG2188	Transcriptional regulator
QF06_02790	COG0778	Nitroreductase
QF06_02795	COG0737	Belongs to the 5'-nucleotidase family
QF06_02800	COG0693	protein deglycase activity
QF06_02805	COG2814	Major facilitator Superfamily
QF06_02810	COG4840	Belongs to the UPF0435 family
QF06_02815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
QF06_02820	COG4980	gas vesicle protein
QF06_02825	COG1295	ribonuclease BN
QF06_02830	COG0477	Major facilitator Superfamily
QF06_02835	COG0387	Pfam Sodium calcium exchanger
QF06_02845	COG0668	transmembrane transport
QF06_02850	COG0535	radical SAM domain protein
QF06_02860	COG0726	polysaccharide deacetylase
QF06_02865	COG2084	Dehydrogenase
QF06_02870	COG0598	Magnesium transport protein CorA
QF06_02875	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
QF06_02880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
QF06_02890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
QF06_02895	COG4637	Psort location Cytoplasmic, score
QF06_02900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
QF06_02905	COG0022	dehydrogenase e1 component
QF06_02910	COG0508	dehydrogenase complex catalyzes the overall conversion of
QF06_02915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
QF06_02920	COG3284	Transcriptional regulator
QF06_02930	COG1742	UPF0060 membrane protein
QF06_02955	COG4842	Belongs to the WXG100 family
QF06_02960	COG1486	melibiose metabolic process
QF06_02965	COG1737	Transcriptional regulator
QF06_02970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_02970	COG1263	PTS System
QF06_02975	COG5434	Belongs to the glycosyl hydrolase 28 family
QF06_02980	COG1132	(ABC) transporter
QF06_02985	COG1132	(ABC) transporter
QF06_02990	COG2259	Doxx family
QF06_02995	COG2514	catechol 2,3-dioxygenase activity
QF06_03000	COG4585	Histidine kinase
QF06_03005	COG2197	response regulator
QF06_03010	COG1131	(ABC) transporter
QF06_03015	COG0842	Transport permease protein
QF06_03015	COG1511	domain protein
QF06_03020	COG0842	Transport permease protein
QF06_03025	COG1695	Transcriptional regulator
QF06_03030	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
QF06_03035	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
QF06_03040	COG2318	DinB family
QF06_03045	COG2814	Major facilitator Superfamily
QF06_03050	COG1846	Transcriptional regulator
QF06_03055	COG0392	lysyltransferase activity
QF06_03055	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
QF06_03060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QF06_03065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_03070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_03075	COG0384	phenazine biosynthesis protein PhzF
QF06_03080	COG0778	Nitroreductase
QF06_03090	COG1090	epimerase
QF06_03095	COG2137	regulation of response to DNA damage stimulus
QF06_03105	COG2814	Major facilitator Superfamily
QF06_03120	COG3103	Sh3 type 3 domain protein
QF06_03125	COG5658	integral membrane protein
QF06_03130	COG0596	Alpha beta hydrolase
QF06_03135	COG0463	Glycosyl transferase, family 2
QF06_03140	COG4485	Bacterial membrane protein, YfhO
QF06_03145	COG1988	membrane-bound metal-dependent
QF06_03150	COG1194	a g-specific adenine glycosylase
QF06_03160	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_03175	COG3557	Belongs to the UPF0374 family
QF06_03180	COG1132	(ABC) transporter
QF06_03185	COG4129	membrane
QF06_03190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
QF06_03195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
QF06_03200	COG0735	belongs to the Fur family
QF06_03310	COG4326	sporulation control protein
QF06_03325	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
QF06_03340	COG0753	catalase activity
QF06_03345	COG1116	anion transmembrane transporter activity
QF06_03350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
QF06_03355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
QF06_03360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QF06_03370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
QF06_03380	COG1476	TRANSCRIPTIONal
QF06_03390	COG3382	B3 4 domain protein
QF06_03395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
QF06_03405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
QF06_03410	COG0789	Transcriptional regulator
QF06_03415	COG1664	Polymer-forming cytoskeletal
QF06_03420	COG1664	Polymer-forming cytoskeletal
QF06_03425	COG2766	serine protein kinase
QF06_03430	COG2718	Belongs to the UPF0229 family
QF06_03435	COG1846	Transcriptional regulator
QF06_03440	COG1566	PFAM secretion protein HlyD family protein
QF06_03445	COG2814	Major facilitator Superfamily
QF06_03450	COG0655	NAD(P)H dehydrogenase (quinone) activity
QF06_03465	COG1725	Transcriptional regulator
QF06_03470	COG1131	(ABC) transporter
QF06_03475	COG1131	(ABC) transporter
QF06_03480	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
QF06_03485	COG1278	Cold shock
QF06_03490	COG1464	Belongs to the NlpA lipoprotein family
QF06_03495	COG3706	GGDEF domain
QF06_03500	COG1823	symporter activity
QF06_03530	COG5577	PFAM Coat F domain
QF06_03535	COG4085	toxin activity
QF06_03535	COG0737	Belongs to the 5'-nucleotidase family
QF06_03535	COG1525	nuclease
QF06_03540	COG3764	Sortase (surface protein transpeptidase)
QF06_03545	COG0564	pseudouridine synthase activity
QF06_03555	COG0517	IMP dehydrogenase activity
QF06_03560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
QF06_03565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
QF06_03565	COG3153	acetyltransferase
QF06_03570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
QF06_03575	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
QF06_03580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
QF06_03585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
QF06_03590	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
QF06_03595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
QF06_03600	COG2203	Gaf domain
QF06_03600	COG4585	Histidine kinase
QF06_03605	COG2197	response regulator
QF06_03610	COG0431	NADPH-dependent FMN reductase
QF06_03625	COG0791	NLP P60 protein
QF06_03625	COG1388	LysM domain
QF06_03630	COG1959	2 iron, 2 sulfur cluster binding
QF06_03635	COG0668	transmembrane transport
QF06_03640	COG2719	SpoVR family
QF06_03645	COG1785	Belongs to the alkaline phosphatase family
QF06_03650	COG0791	NLP P60 protein
QF06_03650	COG1388	LysM domain
QF06_03655	COG0583	DNA-binding transcription factor activity
QF06_03660	COG0372	Belongs to the citrate synthase family
QF06_03665	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_03670	COG0531	amino acid
QF06_03675	COG0733	neurotransmitter:sodium symporter activity
QF06_03680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QF06_03685	COG0456	acetyltransferase
QF06_03700	COG1595	DNA-templated transcription, initiation
QF06_03705	COG0667	Aldo Keto reductase
QF06_03710	COG0204	Acyl-transferase
QF06_03715	COG1253	flavin adenine dinucleotide binding
QF06_03720	COG0789	Transcriptional regulator
QF06_03725	COG0436	Aminotransferase
QF06_03730	COG1253	flavin adenine dinucleotide binding
QF06_03735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
QF06_03740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
QF06_03745	COG0584	glycerophosphoryl diester phosphodiesterase
QF06_03750	COG0668	transmembrane transport
QF06_03755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
QF06_03760	COG0726	polysaccharide deacetylase
QF06_03765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QF06_03770	COG1757	Na H antiporter
QF06_03775	COG0589	response to stress
QF06_03780	COG1132	(ABC) transporter
QF06_03785	COG1132	(ABC) transporter
QF06_03790	COG0702	epimerase
QF06_03805	COG0189	ligase activity
QF06_03810	COG0189	ligase activity
QF06_03815	COG4399	Belongs to the UPF0754 family
QF06_03820	COG3679	Belongs to the UPF0342 family
QF06_03825	COG4335	DNA alkylation repair
QF06_03830	COG0561	phosphatase activity
QF06_03835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
QF06_03840	COG0475	glutathione-regulated potassium exporter activity
QF06_03845	COG0490	domain, Protein
QF06_03855	COG1024	Enoyl-CoA hydratase
QF06_03865	COG4152	abc transporter atp-binding protein
QF06_03870	COG1668	transmembrane transport
QF06_03875	COG0420	3'-5' exonuclease activity
QF06_03880	COG4717	serine-type aminopeptidase activity
QF06_03885	COG3481	metal-dependent phosphohydrolase, HD sub domain
QF06_03895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
QF06_03920	COG1846	Transcriptional regulator
QF06_03925	COG4980	gas vesicle protein
QF06_03940	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
QF06_03945	COG0537	adenosine 5'-monophosphoramidase activity
QF06_03950	COG1131	(ABC) transporter
QF06_03955	COG4473	ABC transporter
QF06_03965	COG1473	amidohydrolase
QF06_03970	COG3069	C4-dicarboxylate transmembrane transporter activity
QF06_03980	COG2329	Antibiotic biosynthesis monooxygenase
QF06_03985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QF06_03990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
QF06_04005	COG1309	transcriptional regulator
QF06_04010	COG1511	domain protein
QF06_04015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
QF06_04020	COG4377	Putative membrane peptidase family (DUF2324)
QF06_04030	COG1363	Peptidase, m42
QF06_04035	COG4405	Protein conserved in bacteria
QF06_04040	COG1301	dicarboxylic acid transport
QF06_04045	COG1234	tRNA 3'-trailer cleavage
QF06_04050	COG0095	Lipoate-protein ligase
QF06_04055	COG0702	epimerase
QF06_04060	COG0318	PFAM AMP-dependent synthetase and ligase
QF06_04070	COG0501	Belongs to the peptidase M48B family
QF06_04080	COG0456	acetyltransferase
QF06_04085	COG0604	alcohol dehydrogenase
QF06_04090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
QF06_04095	COG0406	alpha-ribazole phosphatase activity
QF06_04100	COG0183	Belongs to the thiolase family
QF06_04105	COG0318	PFAM AMP-dependent synthetase and ligase
QF06_04110	COG1268	BioY protein
QF06_04115	COG0840	transmembrane signaling receptor activity
QF06_04120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
QF06_04120	COG0723	plastoquinol--plastocyanin reductase activity
QF06_04125	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_04135	COG4903	ComK protein
QF06_04140	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_04150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QF06_04165	COG0398	Pfam SNARE associated Golgi protein
QF06_04170	COG0681	Belongs to the peptidase S26 family
QF06_04175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
QF06_04180	COG1846	Transcriptional regulator
QF06_04195	COG0738	Major facilitator superfamily
QF06_04200	COG0673	inositol 2-dehydrogenase activity
QF06_04205	COG0561	phosphatase activity
QF06_04210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
QF06_04215	COG1609	Transcriptional regulator
QF06_04220	COG3180	Ammonia monooxygenase
QF06_04225	COG0477	Major facilitator Superfamily
QF06_04225	COG2814	Major facilitator Superfamily
QF06_04230	COG4533	DNA binding
QF06_04240	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
QF06_04245	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
QF06_04250	COG1074	ATP-dependent DNA helicase activity
QF06_04255	COG0420	3'-5' exonuclease activity
QF06_04260	COG0419	ATPase involved in DNA repair
QF06_04265	COG1403	HNH endonuclease
QF06_04305	COG5337	Spore coat protein CotH
QF06_04310	COG0179	Fumarylacetoacetate (FAA) hydrolase
QF06_04320	COG1404	Belongs to the peptidase S8 family
QF06_04330	COG0367	asparagine synthase
QF06_04335	COG2318	DinB family
QF06_04340	COG1562	ergosterol biosynthetic process
QF06_04345	COG0534	Mate efflux family protein
QF06_04350	COG2207	Transcriptional regulator
QF06_04350	COG1917	Cupin 2, conserved barrel domain protein
QF06_04355	COG1609	Transcriptional regulator
QF06_04360	COG0673	inositol 2-dehydrogenase activity
QF06_04365	COG2318	DinB family
QF06_04370	COG1279	arginine transmembrane transporter activity
QF06_04375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
QF06_04380	COG1357	PFAM Pentapeptide repeats (8 copies)
QF06_04385	COG2267	carboxylic ester hydrolase activity
QF06_04390	COG0529	Catalyzes the synthesis of activated sulfate
QF06_04395	COG2046	Belongs to the sulfate adenylyltransferase family
QF06_04400	COG0175	sulfate reduction
QF06_04405	COG2045	Belongs to the ComB family
QF06_04410	COG1809	phosphosulfolactate synthase activity
QF06_04415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QF06_04420	COG4948	Mandelate Racemase Muconate Lactonizing
QF06_04425	COG2814	Major facilitator Superfamily
QF06_04430	COG0454	-acetyltransferase
QF06_04435	COG2153	protein acetylation
QF06_04440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
QF06_04440	COG0646	methionine synthase
QF06_04445	COG1666	GTP binding
QF06_04450	COG2996	Protein conserved in bacteria
QF06_04470	COG1695	Transcriptional regulator
QF06_04485	COG3227	Zinc metalloprotease (Elastase)
QF06_04490	COG1307	EDD domain protein, DegV family
QF06_04495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QF06_04510	COG0561	phosphatase activity
QF06_04515	COG1073	alpha beta
QF06_04520	COG2151	metal-sulfur cluster biosynthetic enzyme
QF06_04525	COG0277	FAD linked oxidase domain protein
QF06_04530	COG2271	Major facilitator Superfamily
QF06_04535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
QF06_04550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
QF06_04555	COG0505	Belongs to the CarA family
QF06_04560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
QF06_04565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
QF06_04580	COG2267	carboxylic ester hydrolase activity
QF06_04590	COG1744	ABC transporter substrate-binding protein PnrA-like
QF06_04605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
QF06_04610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
QF06_04615	COG5504	Zn-dependent protease
QF06_04620	COG0444	Belongs to the ABC transporter superfamily
QF06_04625	COG4608	Belongs to the ABC transporter superfamily
QF06_04635	COG0601	transmembrane transport
QF06_04640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
QF06_04650	COG0180	Tryptophanyl-tRNA synthetase
QF06_04655	COG4166	transmembrane transport
QF06_04660	COG0601	transmembrane transport
QF06_04665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
QF06_04670	COG0444	Belongs to the ABC transporter superfamily
QF06_04675	COG4608	Belongs to the ABC transporter superfamily
QF06_04680	COG2814	Major facilitator Superfamily
QF06_04685	COG0456	acetyltransferase
QF06_04690	COG1393	Belongs to the ArsC family
QF06_04695	COG0861	Integral membrane protein TerC family
QF06_04700	COG4862	establishment of competence for transformation
QF06_04705	COG4469	Competence protein
QF06_04710	COG1164	Oligoendopeptidase f
QF06_04730	COG2346	COG2346, Truncated hemoglobins
QF06_04735	COG0741	lytic transglycosylase activity
QF06_04740	COG4116	CYTH
QF06_04750	COG2357	RelA SpoT domain protein
QF06_04755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
QF06_04760	COG0564	pseudouridine synthase activity
QF06_04765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
QF06_04770	COG0569	domain protein
QF06_04770	COG0475	glutathione-regulated potassium exporter activity
QF06_04775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
QF06_04780	COG0352	thiamine-phosphate diphosphorylase activity
QF06_04785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
QF06_04790	COG2104	thiamine diphosphate biosynthetic process
QF06_04795	COG2022	thiamine diphosphate biosynthetic process
QF06_04800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
QF06_04805	COG0351	phosphomethylpyrimidine kinase
QF06_04810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
QF06_04865	COG0210	DNA helicase
QF06_04875	COG2153	protein acetylation
QF06_04880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
QF06_04885	COG2382	esterase
QF06_04890	COG0626	cystathionine gamma-synthase activity
QF06_04895	COG0626	cystathionine gamma-synthase activity
QF06_04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_04905	COG5505	Protein of unknown function (DUF819)
QF06_04940	COG5444	nuclease activity
QF06_04965	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
QF06_04970	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_04980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_04980	COG3711	transcriptional antiterminator
QF06_04985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_04985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QF06_04985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QF06_04990	COG1482	cell wall glycoprotein biosynthetic process
QF06_05000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_05010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
QF06_05025	COG0109	protoheme IX farnesyltransferase activity
QF06_05035	COG0726	polysaccharide deacetylase
QF06_05050	COG2205	protein histidine kinase activity
QF06_05060	COG3383	formate dehydrogenase (NAD+) activity
QF06_05065	COG2427	Protein of unknown function (DUF1641)
QF06_05085	COG2124	cytochrome p450
QF06_05090	COG1819	glycosyl
QF06_05110	COG1587	Uroporphyrinogen-III synthase
QF06_05115	COG0390	transport system, permease component
QF06_05120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
QF06_05125	COG0697	spore germination
QF06_05130	COG4297	protein containing double-stranded beta helix domain
QF06_05145	COG1904	glucuronate isomerase
QF06_05150	COG2211	Major facilitator Superfamily
QF06_05155	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
QF06_05160	COG1063	alcohol dehydrogenase
QF06_05165	COG1312	Catalyzes the dehydration of D-mannonate
QF06_05170	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_05175	COG2271	Major facilitator Superfamily
QF06_05180	COG1609	Transcriptional regulator
QF06_05185	COG0246	Mannitol dehydrogenase
QF06_05190	COG2721	sulfolactate sulfo-lyase activity
QF06_05195	COG0730	response to heat
QF06_05200	COG2318	DinB family
QF06_05205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
QF06_05210	COG0457	Tetratricopeptide repeat
QF06_05220	COG2350	Protein conserved in bacteria
QF06_05225	COG1388	LysM domain
QF06_05225	COG5632	N-Acetylmuramoyl-L-alanine amidase
QF06_05225	COG3409	Peptidoglycan-binding domain 1 protein
QF06_05235	COG4195	phage-related replication protein
QF06_05240	COG3546	catalase activity
QF06_05245	COG2856	Zn peptidase
QF06_05250	COG1396	sequence-specific DNA binding
QF06_05260	COG1522	sequence-specific DNA binding
QF06_05265	COG1484	DNA-dependent DNA replication
QF06_05280	COG1595	DNA-templated transcription, initiation
QF06_05285	COG3728	DNA packaging
QF06_05285	COG5484	DNA packaging
QF06_05290	COG1783	phage Terminase large subunit
QF06_05295	COG5518	Phage portal protein
QF06_05300	COG0338	D12 class N6 adenine-specific DNA methyltransferase
QF06_05305	COG4653	Phage capsid family
QF06_05350	COG5412	phage tail tape measure protein
QF06_05350	COG3953	SLT domain
QF06_05355	COG1652	LysM domain
QF06_05360	COG4193	domain, Protein
QF06_05370	COG3628	GPW Gp25 family protein
QF06_05375	COG3299	homolog of phage Mu protein gp47
QF06_05380	COG3778	Protein conserved in bacteria
QF06_05420	COG5632	N-Acetylmuramoyl-L-alanine amidase
QF06_05420	COG3409	Peptidoglycan-binding domain 1 protein
QF06_05435	COG0306	phosphate transporter
QF06_05440	COG1392	Phosphate transport regulator
QF06_05445	COG0531	amino acid
QF06_05450	COG0346	lactoylglutathione lyase activity
QF06_05455	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
QF06_05460	COG0463	Glycosyl transferase, family 2
QF06_05465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QF06_05470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
QF06_05475	COG2362	D-Aminopeptidase
QF06_05480	COG0601	transmembrane transport
QF06_05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
QF06_05490	COG0444	Belongs to the ABC transporter superfamily
QF06_05495	COG4166	transmembrane transport
QF06_05500	COG1619	proteins homologs of microcin C7 resistance protein MccF
QF06_05505	COG4948	Mandelate Racemase Muconate Lactonizing
QF06_05510	COG0791	NLP P60 protein
QF06_05515	COG4608	Belongs to the ABC transporter superfamily
QF06_05520	COG2706	6-phosphogluconolactonase activity
QF06_05525	COG1834	amidinotransferase
QF06_05530	COG1607	acyl-coa hydrolase
QF06_05535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
QF06_05535	COG1017	nitric oxide dioxygenase activity
QF06_05545	COG2323	membrane
QF06_05550	COG2318	DinB family
QF06_05555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_05560	COG2076	Multidrug Resistance protein
QF06_05565	COG2076	Multidrug Resistance protein
QF06_05570	COG0788	formyltetrahydrofolate deformylase activity
QF06_05575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
QF06_05580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
QF06_05585	COG1764	response to oxidative stress
QF06_05590	COG1846	Transcriptional regulator
QF06_05595	COG1764	response to oxidative stress
QF06_05605	COG0590	tRNA wobble adenosine to inosine editing
QF06_05610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
QF06_05615	COG1404	Belongs to the peptidase S8 family
QF06_05620	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_05625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
QF06_05630	COG1122	ATPase activity
QF06_05635	COG4721	ABC-type cobalt transport system, permease component
QF06_05645	COG0745	RESPONSE REGULATOR receiver
QF06_05650	COG3850	Histidine kinase
QF06_05650	COG5002	protein histidine kinase activity
QF06_05655	COG3212	peptidase
QF06_05660	COG3212	peptidase
QF06_05670	COG2239	Acts as a magnesium transporter
QF06_05675	COG0789	Transcriptional regulator
QF06_05685	COG1846	Transcriptional regulator
QF06_05690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
QF06_05695	COG0726	polysaccharide deacetylase
QF06_05700	COG1408	metallophosphoesterase
QF06_05710	COG0463	Glycosyl transferase, family 2
QF06_05715	COG1793	dna ligase
QF06_05715	COG3285	dna ligase
QF06_05720	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
QF06_05725	COG5001	Diguanylate cyclase
QF06_05725	COG3300	MHYT domain
QF06_05730	COG0586	Pfam SNARE associated Golgi protein
QF06_05735	COG0861	Integral membrane protein TerC family
QF06_05740	COG1191	sigma factor activity
QF06_05760	COG0501	Belongs to the peptidase M48B family
QF06_05765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
QF06_05770	COG3594	Acyltransferase
QF06_05775	COG5002	protein histidine kinase activity
QF06_05780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
QF06_05785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
QF06_05790	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
QF06_05795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
QF06_05800	COG0436	Aminotransferase
QF06_05805	COG1850	ribulose-bisphosphate carboxylase activity
QF06_05810	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
QF06_05815	COG0235	Class ii aldolase
QF06_05820	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
QF06_05825	COG3339	Conserved Protein
QF06_05840	COG3852	Histidine kinase
QF06_05845	COG1846	Transcriptional regulator
QF06_05850	COG1360	Flagellar Motor Protein
QF06_05855	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
QF06_05860	COG0542	response to heat
QF06_05865	COG3949	Membrane
QF06_05870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
QF06_05875	COG0720	synthase
QF06_05880	COG0602	queuosine metabolic process
QF06_05885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
QF06_05890	COG1733	regulation of RNA biosynthetic process
QF06_05895	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_05900	COG1388	LysM domain
QF06_05900	COG4641	Protein conserved in bacteria
QF06_05905	COG1388	LysM domain
QF06_05910	COG3858	chitin binding
QF06_05915	COG3858	chitin binding
QF06_05925	COG4873	Protein conserved in bacteria
QF06_05935	COG3773	Cell wall hydrolase
QF06_05940	COG2244	polysaccharide biosynthetic process
QF06_05945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_05950	COG2217	Heavy metal translocating P-type atpase
QF06_05960	COG0006	proline dipeptidase activity
QF06_05965	COG1609	Transcriptional regulator
QF06_05970	COG3711	transcriptional antiterminator
QF06_05975	COG1263	PTS System
QF06_05975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_05975	COG2190	(PTS) system
QF06_05980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_05985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
QF06_05995	COG1533	DNA photolyase activity
QF06_06000	COG0456	acetyltransferase
QF06_06005	COG0840	transmembrane signaling receptor activity
QF06_06010	COG2084	Dehydrogenase
QF06_06015	COG4257	antibiotic catabolic process
QF06_06020	COG2340	Cysteine-rich secretory protein family
QF06_06025	COG0768	penicillin binding
QF06_06030	COG4191	Histidine kinase
QF06_06035	COG0436	Aminotransferase
QF06_06040	COG0784	Response regulator, receiver
QF06_06040	COG0835	chemotaxis
QF06_06050	COG2814	Major facilitator Superfamily
QF06_06055	COG1376	ErfK ybiS ycfS ynhG family protein
QF06_06060	COG1408	metallophosphoesterase
QF06_06065	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_06070	COG2200	EAL domain
QF06_06075	COG4703	Protein of unknown function (DUF1797)
QF06_06080	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
QF06_06090	COG0517	IMP dehydrogenase activity
QF06_06095	COG0583	DNA-binding transcription factor activity
QF06_06100	COG0716	FMN binding
QF06_06110	COG0716	FMN binding
QF06_06115	COG2171	N-acyltransferase activity
QF06_06120	COG1473	amidohydrolase
QF06_06130	COG0668	transmembrane transport
QF06_06135	COG0450	alkyl hydroperoxide reductase
QF06_06140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_06155	COG0746	molybdenum cofactor guanylyltransferase activity
QF06_06160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
QF06_06165	COG0303	'Molybdopterin
QF06_06170	COG1763	Mo-molybdopterin cofactor biosynthetic process
QF06_06175	COG0314	molybdopterin synthase activity
QF06_06180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
QF06_06185	COG1132	(ABC) transporter
QF06_06190	COG1132	(ABC) transporter
QF06_06200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
QF06_06205	COG1136	(ABC) transporter
QF06_06210	COG0577	efflux transmembrane transporter activity
QF06_06215	COG1349	DNA-binding transcription factor activity
QF06_06220	COG1105	Belongs to the carbohydrate kinase PfkB family
QF06_06225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QF06_06225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_06225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
QF06_06230	COG0681	Belongs to the peptidase S26 family
QF06_06240	COG0488	(ABC) transporter
QF06_06245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
QF06_06250	COG2309	aminopeptidase activity
QF06_06255	COG1077	Cell shape determining protein MreB Mrl
QF06_06260	COG2002	toxin-antitoxin pair type II binding
QF06_06265	COG3852	Histidine kinase
QF06_06270	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
QF06_06270	COG2105	PFAM AIG2 family protein
QF06_06275	COG0569	domain protein
QF06_06280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
QF06_06285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
QF06_06295	COG0561	phosphatase activity
QF06_06300	COG0242	peptide deformylase activity
QF06_06310	COG0497	DNA recombination
QF06_06315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
QF06_06320	COG0022	dehydrogenase e1 component
QF06_06325	COG0508	dehydrogenase complex catalyzes the overall conversion of
QF06_06330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
QF06_06335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_06340	COG1982	Orn Lys Arg decarboxylase major
QF06_06345	COG4476	Belongs to the UPF0223 family
QF06_06350	COG4493	Belongs to the UPF0637 family
QF06_06360	COG0483	inositol monophosphate 1-phosphatase activity
QF06_06370	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
QF06_06420	COG4896	Protein conserved in bacteria
QF06_06430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
QF06_06435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
QF06_06440	COG2066	Belongs to the glutaminase family
QF06_06445	COG4838	Belongs to the UPF0358 family
QF06_06450	COG0772	Belongs to the SEDS family
QF06_06455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
QF06_06460	COG1612	heme a metabolic process
QF06_06465	COG0109	protoheme IX farnesyltransferase activity
QF06_06470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
QF06_06470	COG2010	Cytochrome c
QF06_06475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
QF06_06480	COG1845	cytochrome c oxidase, subunit III
QF06_06485	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
QF06_06490	COG3336	cytochrome c oxidase
QF06_06500	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
QF06_06505	COG2340	Cysteine-rich secretory protein family
QF06_06520	COG3679	Belongs to the UPF0342 family
QF06_06525	COG4471	UPF0298 protein
QF06_06530	COG0742	ribosomal rna small subunit methyltransferase
QF06_06535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
QF06_06540	COG3314	Sporulation integral membrane protein YlbJ
QF06_06545	COG1752	Esterase of the alpha-beta hydrolase superfamily
QF06_06550	COG3480	Lon protease (S16) C-terminal proteolytic domain
QF06_06555	COG1323	Belongs to the UPF0348 family
QF06_06565	COG1399	metal-binding, possibly nucleic acid-binding protein
QF06_06575	COG0454	-acetyltransferase
QF06_06580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
QF06_06585	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
QF06_06590	COG2001	Belongs to the MraZ family
QF06_06595	COG0275	rRNA processing
QF06_06600	COG4839	cell division protein FtsL
QF06_06610	COG0768	penicillin binding
QF06_06615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
QF06_06620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
QF06_06625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
QF06_06630	COG0772	Belongs to the SEDS family
QF06_06635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
QF06_06640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
QF06_06645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
QF06_06650	COG3879	Bacterial protein of unknown function (DUF881)
QF06_06655	COG3879	Bacterial protein of unknown function (DUF881)
QF06_06660	COG3856	small basic protein
QF06_06665	COG0849	cell division
QF06_06670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
QF06_06675	COG1404	Belongs to the peptidase S8 family
QF06_06675	COG4412	M6 family metalloprotease domain protein
QF06_06685	COG1191	sigma factor activity
QF06_06690	COG1191	sigma factor activity
QF06_06695	COG1119	ATPase activity
QF06_06700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
QF06_06705	COG1873	PFAM PRC-barrel domain
QF06_06715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
QF06_06720	COG1799	cell septum assembly
QF06_06725	COG0762	integral membrane protein
QF06_06730	COG2302	S4 RNA-binding domain
QF06_06735	COG3599	regulation of cell shape
QF06_06740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
QF06_06745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
QF06_06750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
QF06_06755	COG0564	pseudouridine synthase activity
QF06_06760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
QF06_06765	COG2233	PERMEase
QF06_06770	COG0540	Belongs to the ATCase OTCase family
QF06_06775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
QF06_06780	COG0505	Belongs to the CarA family
QF06_06785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
QF06_06790	COG0543	2 iron, 2 sulfur cluster binding
QF06_06795	COG0167	dihydroorotate dehydrogenase activity
QF06_06800	COG0284	orotidine-5'-phosphate decarboxylase activity
QF06_06805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
QF06_06810	COG0175	sulfate reduction
QF06_06815	COG0306	phosphate transporter
QF06_06820	COG2046	Belongs to the sulfate adenylyltransferase family
QF06_06825	COG0529	Catalyzes the synthesis of activated sulfate
QF06_06830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
QF06_06835	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
QF06_06840	COG1648	precorrin-2 dehydrogenase activity
QF06_06850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
QF06_06855	COG1561	YicC-like family, N-terminal region
QF06_06860	COG2052	Domain of unknown function (DUF370)
QF06_06865	COG0194	GDP metabolic process
QF06_06870	COG1758	RNA polymerase activity
QF06_06875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
QF06_06880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
QF06_06885	COG0242	peptide deformylase activity
QF06_06890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
QF06_06895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
QF06_06895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
QF06_06900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
QF06_06905	COG0631	protein serine/threonine phosphatase activity
QF06_06910	COG2815	serine threonine protein kinase
QF06_06910	COG0515	serine threonine protein kinase
QF06_06915	COG1162	GTPase activity
QF06_06920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
QF06_06925	COG1564	THIamine pyrophosphokinase
QF06_06935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
QF06_06940	COG1302	Protein conserved in bacteria
QF06_06945	COG1461	Dihydroxyacetone kinase
QF06_06950	COG1760	l-serine dehydratase
QF06_06955	COG1760	l-serine dehydratase
QF06_06960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
QF06_06965	COG2050	protein possibly involved in aromatic compounds catabolism
QF06_06965	COG1349	DNA-binding transcription factor activity
QF06_06970	COG0416	fatty acid biosynthetic process
QF06_06975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
QF06_06980	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_06985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QF06_06990	COG0571	ribonuclease III activity
QF06_06995	COG1196	nuclear chromosome segregation
QF06_07000	COG0552	protein localization to endoplasmic reticulum
QF06_07010	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
QF06_07015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
QF06_07020	COG0228	four-way junction DNA binding
QF06_07025	COG1837	Belongs to the UPF0109 family
QF06_07035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
QF06_07040	COG0336	Belongs to the RNA methyltransferase TrmD family
QF06_07045	COG0335	large ribosomal subunit rRNA binding
QF06_07050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
QF06_07055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
QF06_07065	COG2257	FlhB HrpN YscU SpaS Family
QF06_07070	COG0045	succinate-CoA ligase (ADP-forming) activity
QF06_07075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
QF06_07080	COG0758	DNA mediated transformation
QF06_07085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
QF06_07090	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
QF06_07095	COG4974	Belongs to the 'phage' integrase family
QF06_07100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
QF06_07105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
QF06_07110	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
QF06_07115	COG1815	bacterial-type flagellum-dependent cell motility
QF06_07120	COG1558	bacterial-type flagellum-dependent cell motility
QF06_07125	COG1677	Flagellar hook-basal body complex protein FliE
QF06_07130	COG1766	The M ring may be actively involved in energy transduction
QF06_07135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
QF06_07140	COG1317	bacterial-type flagellum organization
QF06_07145	COG1157	protein secretion by the type III secretion system
QF06_07150	COG2882	bacterial-type flagellum organization
QF06_07155	COG3334	PFAM MgtE intracellular
QF06_07160	COG3144	bacterial-type flagellum assembly
QF06_07165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
QF06_07170	COG4786	Flagellar basal body rod
QF06_07175	COG1582	Flagellar protein (FlbD)
QF06_07180	COG1580	Controls the rotational direction of flagella during chemotaxis
QF06_07185	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
QF06_07190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
QF06_07190	COG1776	CheC inhibitor of MCP methylation
QF06_07195	COG2201	protein-glutamate methylesterase activity
QF06_07200	COG3190	flagellar
QF06_07205	COG1338	Plays a role in the flagellum-specific transport system
QF06_07210	COG1987	bacterial-type flagellum assembly
QF06_07215	COG1684	flagellar biosynthetic protein fliR
QF06_07220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
QF06_07225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
QF06_07230	COG1419	protein localization to endoplasmic reticulum
QF06_07235	COG0455	bacterial-type flagellum organization
QF06_07240	COG2201	protein-glutamate methylesterase activity
QF06_07245	COG0643	Histidine kinase
QF06_07245	COG2198	Histidine kinase
QF06_07250	COG0835	chemotaxis
QF06_07255	COG1776	CheC inhibitor of MCP methylation
QF06_07260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
QF06_07265	COG1191	sigma factor activity
QF06_07275	COG0052	Belongs to the universal ribosomal protein uS2 family
QF06_07280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
QF06_07285	COG0528	UMP kinase activity
QF06_07290	COG0233	cytoplasmic translational termination
QF06_07295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
QF06_07300	COG4589	Belongs to the CDS family
QF06_07305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
QF06_07310	COG0750	zinc metalloprotease
QF06_07315	COG0442	prolyl-tRNA aminoacylation
QF06_07320	COG2176	DNA-directed DNA polymerase activity
QF06_07345	COG0779	Required for maturation of 30S ribosomal subunits
QF06_07350	COG0195	Participates in both transcription termination and antitermination
QF06_07355	COG2740	Nucleic-acid-binding protein implicated in transcription termination
QF06_07360	COG1358	cellular component organization or biogenesis
QF06_07365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
QF06_07370	COG1550	Protein conserved in bacteria
QF06_07375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
QF06_07380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
QF06_07385	COG0196	riboflavin kinase activity
QF06_07390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
QF06_07395	COG1185	polyribonucleotide nucleotidyltransferase activity
QF06_07400	COG0726	polysaccharide deacetylase
QF06_07405	COG0612	Peptidase, M16
QF06_07410	COG1873	PFAM PRC-barrel domain
QF06_07415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
QF06_07420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
QF06_07425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
QF06_07430	COG0527	aspartate kinase activity
QF06_07435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
QF06_07440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
QF06_07445	COG0740	serine-type endopeptidase activity
QF06_07455	COG1674	ftsk spoiiie
QF06_07455	COG4980	gas vesicle protein
QF06_07460	COG2188	Transcriptional regulator
QF06_07465	COG2814	Major facilitator Superfamily
QF06_07470	COG0612	Peptidase, M16
QF06_07475	COG0612	Peptidase, M16
QF06_07480	COG0300	oxidoreductase activity
QF06_07495	COG1426	Protein conserved in bacteria
QF06_07500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
QF06_07505	COG1058	Belongs to the CinA family
QF06_07505	COG1546	Belongs to the CinA family
QF06_07510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
QF06_07515	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
QF06_07520	COG1418	mRNA catabolic process
QF06_07525	COG1692	metallophosphoesterase
QF06_07530	COG2359	stage V sporulation protein S
QF06_07535	COG1063	alcohol dehydrogenase
QF06_07540	COG0156	8-amino-7-oxononanoate synthase activity
QF06_07545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
QF06_07550	COG4550	Control of competence regulator ComK, YlbF/YmcA
QF06_07560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
QF06_07565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
QF06_07580	COG3226	Transcriptional regulator
QF06_07585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_07595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
QF06_07600	COG3321	synthase
QF06_07605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
QF06_07605	COG2070	2-Nitropropane dioxygenase
QF06_07610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QF06_07615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
QF06_07620	COG3425	synthase
QF06_07625	COG1024	Enoyl-CoA hydratase
QF06_07630	COG1024	Enoyl-CoA hydratase
QF06_07635	COG0318	PFAM AMP-dependent synthetase and ligase
QF06_07635	COG3321	synthase
QF06_07635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_07635	COG0300	oxidoreductase activity
QF06_07635	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_07640	COG4221	oxidoreductase activity
QF06_07640	COG0300	oxidoreductase activity
QF06_07640	COG3321	synthase
QF06_07640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QF06_07645	COG3321	synthase
QF06_07645	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_07645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_07645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
QF06_07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QF06_07650	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_07650	COG3321	synthase
QF06_07650	COG4221	oxidoreductase activity
QF06_07650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_07655	COG3321	synthase
QF06_07655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QF06_07655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
QF06_07655	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
QF06_07660	COG2124	cytochrome p450
QF06_07670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_07675	COG1404	Belongs to the peptidase S8 family
QF06_07685	COG4195	phage-related replication protein
QF06_07690	COG1764	response to oxidative stress
QF06_07695	COG2076	Multidrug Resistance protein
QF06_07700	COG2076	Multidrug Resistance protein
QF06_07715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
QF06_07720	COG1923	regulation of RNA biosynthetic process
QF06_07735	COG1780	Probably involved in ribonucleotide reductase function
QF06_07740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
QF06_07745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
QF06_07750	COG4112	unkown
QF06_07755	COG0860	N-Acetylmuramoyl-L-alanine amidase
QF06_07760	COG0464	growth
QF06_07765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
QF06_07770	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
QF06_07775	COG0789	Transcriptional regulator
QF06_07780	COG0174	glutamine synthetase
QF06_07805	COG4282	regulation of fungal-type cell wall biogenesis
QF06_07810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_07830	COG0135	phosphoribosylanthranilate isomerase activity
QF06_07835	COG2211	Major facilitator Superfamily
QF06_07840	COG3507	Belongs to the glycosyl hydrolase 43 family
QF06_07845	COG1940	carbohydrate kinase activity
QF06_07850	COG2115	Belongs to the xylose isomerase family
QF06_07855	COG1070	Carbohydrate kinase
QF06_07865	COG2814	Major facilitator Superfamily
QF06_07870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
QF06_07885	COG0756	dUTP diphosphatase activity
QF06_07920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
QF06_07930	COG3832	glyoxalase III activity
QF06_07940	COG0697	spore germination
QF06_07945	COG0531	amino acid
QF06_07975	COG4195	phage-related replication protein
QF06_07985	COG0346	lactoylglutathione lyase activity
QF06_07990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
QF06_07995	COG1388	LysM domain
QF06_08000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
QF06_08005	COG4224	UPF0291 protein
QF06_08010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
QF06_08020	COG3763	UPF0154 protein
QF06_08030	COG0785	Cytochrome C biogenesis protein
QF06_08035	COG2201	protein-glutamate methylesterase activity
QF06_08040	COG4846	Membrane protein involved in cytochrome C biogenesis
QF06_08050	COG0071	Belongs to the small heat shock protein (HSP20) family
QF06_08065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
QF06_08070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_08090	COG0824	Thioesterase
QF06_08100	COG4841	protein insertion into membrane
QF06_08105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
QF06_08110	COG1832	CoA-binding protein
QF06_08115	COG0187	DNA topoisomerase II activity
QF06_08120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
QF06_08130	COG1115	amino acid carrier protein
QF06_08135	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
QF06_08145	COG5520	Belongs to the glycosyl hydrolase 30 family
QF06_08150	COG3507	Belongs to the glycosyl hydrolase 43 family
QF06_08155	COG2246	polysaccharide biosynthetic process
QF06_08160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
QF06_08165	COG0586	Pfam SNARE associated Golgi protein
QF06_08170	COG2404	hydrolase activity, acting on ester bonds
QF06_08175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
QF06_08180	COG1024	Enoyl-CoA hydratase
QF06_08185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
QF06_08190	COG0511	ligase activity, forming carbon-carbon bonds
QF06_08195	COG0439	Biotin carboxylase
QF06_08200	COG0318	PFAM AMP-dependent synthetase and ligase
QF06_08205	COG1960	acyl-CoA dehydrogenase activity
QF06_08215	COG1649	PFAM Uncharacterised BCR, COG1649
QF06_08225	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
QF06_08225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_08235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_08240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_08245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_08250	COG2027	D-alanyl-D-alanine carboxypeptidase
QF06_08255	COG2017	converts alpha-aldose to the beta-anomer
QF06_08260	COG0534	Mate efflux family protein
QF06_08275	COG0582	viral genome integration into host DNA
QF06_08280	COG0166	Belongs to the GPI family
QF06_08285	COG0405	Gamma-glutamyltransferase
QF06_08290	COG0583	DNA-binding transcription factor activity
QF06_08295	COG0604	alcohol dehydrogenase
QF06_08300	COG0493	'glutamate synthase
QF06_08305	COG0067	glutamate synthase
QF06_08305	COG0069	glutamate synthase activity
QF06_08305	COG0070	glutamate synthase
QF06_08310	COG0583	DNA-binding transcription factor activity
QF06_08315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
QF06_08320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
QF06_08330	COG0300	oxidoreductase activity
QF06_08335	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
QF06_08345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_08360	COG1131	(ABC) transporter
QF06_08370	COG2814	Major facilitator Superfamily
QF06_08375	COG1070	Carbohydrate kinase
QF06_08385	COG0243	molybdopterin cofactor binding
QF06_08395	COG2814	Major facilitator Superfamily
QF06_08400	COG0673	inositol 2-dehydrogenase activity
QF06_08405	COG1082	Xylose isomerase domain protein TIM barrel
QF06_08410	COG1609	Transcriptional regulator
QF06_08430	COG0840	transmembrane signaling receptor activity
QF06_08430	COG5278	phosphoserine phosphatase activity
QF06_08435	COG2368	4-hydroxyphenylacetate
QF06_08440	COG4305	rare lipoprotein A
QF06_08445	COG3619	membrane
QF06_08450	COG3866	Pectate lyase
QF06_08455	COG2135	peptidase activity
QF06_08465	COG2140	Oxalate decarboxylase
QF06_08485	COG2720	vancomycin resistance protein
QF06_08495	COG3655	Transcriptional regulator
QF06_08500	COG3739	integral membrane protein
QF06_08505	COG0583	DNA-binding transcription factor activity
QF06_08510	COG0697	spore germination
QF06_08520	COG0693	protein deglycase activity
QF06_08525	COG2367	Beta-lactamase
QF06_08540	COG3848	Pyruvate phosphate dikinase
QF06_08540	COG0574	Belongs to the PEP-utilizing enzyme family
QF06_08545	COG0726	polysaccharide deacetylase
QF06_08550	COG2314	TM2 domain
QF06_08605	COG0457	Tetratricopeptide repeat
QF06_08615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
QF06_08620	COG5444	nuclease activity
QF06_08625	COG4282	regulation of fungal-type cell wall biogenesis
QF06_08630	COG1231	oxidoreductase activity
QF06_08635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QF06_08640	COG2207	Transcriptional regulator
QF06_08640	COG0662	Cupin 2, conserved barrel domain protein
QF06_08645	COG0456	acetyltransferase
QF06_08650	COG1309	transcriptional regulator
QF06_08655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_08660	COG3708	Transcriptional regulator
QF06_08665	COG2378	regulation of single-species biofilm formation
QF06_08675	COG0640	Transcriptional regulator
QF06_08680	COG0741	lytic transglycosylase activity
QF06_08685	COG2322	membrane
QF06_08700	COG1619	proteins homologs of microcin C7 resistance protein MccF
QF06_08705	COG3239	Fatty acid desaturase
QF06_08710	COG4585	Histidine kinase
QF06_08715	COG2197	response regulator
QF06_08720	COG3584	3D domain protein
QF06_08720	COG1388	LysM domain
QF06_08725	COG0514	ATP-dependent DNA helicase (RecQ)
QF06_08735	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
QF06_08740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
QF06_08755	COG0071	Belongs to the small heat shock protein (HSP20) family
QF06_08780	COG1012	belongs to the aldehyde dehydrogenase family
QF06_08785	COG1657	PFAM Prenyltransferase squalene oxidase
QF06_08790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
QF06_08795	COG0733	neurotransmitter:sodium symporter activity
QF06_08800	COG0385	Bile acid
QF06_08805	COG0508	dehydrogenase complex catalyzes the overall conversion of
QF06_08810	COG0567	Dehydrogenase, E1 component
QF06_08815	COG4548	von Willebrand factor, type A
QF06_08820	COG0714	Associated with various cellular activities
QF06_08825	COG2032	superoxide dismutase activity
QF06_08830	COG1388	LysM domain
QF06_08830	COG0791	NLP P60 protein
QF06_08835	COG1819	glycosyl
QF06_08840	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
QF06_08845	COG0534	Mate efflux family protein
QF06_08850	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_08855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
QF06_08860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
QF06_08870	COG2962	Rard protein
QF06_08885	COG2610	gluconate transmembrane transporter activity
QF06_08890	COG1942	4-Oxalocrotonate Tautomerase
QF06_08895	COG1733	regulation of RNA biosynthetic process
QF06_08900	COG0778	Nitroreductase
QF06_08905	COG0400	carboxylic ester hydrolase activity
QF06_08910	COG0346	lactoylglutathione lyase activity
QF06_08920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QF06_08925	COG0793	Belongs to the peptidase S41A family
QF06_08925	COG3409	Peptidoglycan-binding domain 1 protein
QF06_08930	COG2226	methyltransferase
QF06_08940	COG1876	peptidase activity
QF06_08945	COG0813	purine-nucleoside phosphorylase activity
QF06_08955	COG0671	phosphoesterase, PA-phosphatase related
QF06_08970	COG4479	Belongs to the UPF0346 family
QF06_08980	COG1509	lysine 2,3-aminomutase activity
QF06_08985	COG0456	acetyltransferase
QF06_08990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
QF06_08995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
QF06_09000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
QF06_09005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
QF06_09015	COG0456	acetyltransferase
QF06_09020	COG0463	Glycosyl transferase, family 2
QF06_09035	COG4641	Protein conserved in bacteria
QF06_09040	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
QF06_09045	COG1086	Polysaccharide biosynthesis protein
QF06_09050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
QF06_09055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
QF06_09060	COG1846	Transcriptional regulator
QF06_09065	COG0534	Mate efflux family protein
QF06_09075	COG4698	Protein conserved in bacteria
QF06_09080	COG2755	lipolytic protein G-D-S-L family
QF06_09085	COG1999	signal sequence binding
QF06_09095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
QF06_09100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
QF06_09105	COG1272	protein, Hemolysin III
QF06_09110	COG0204	Acyl-transferase
QF06_09115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
QF06_09120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
QF06_09130	COG2136	Putative SAM-dependent methyltransferase
QF06_09130	COG2521	methyltransferase
QF06_09140	COG0129	dihydroxy-acid dehydratase activity
QF06_09145	COG1413	lyase activity
QF06_09150	COG1418	mRNA catabolic process
QF06_09155	COG0386	Belongs to the glutathione peroxidase family
QF06_09160	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
QF06_09165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
QF06_09170	COG1278	Cold shock
QF06_09190	COG0328	RNA-DNA hybrid ribonuclease activity
QF06_09195	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
QF06_09200	COG0328	RNA-DNA hybrid ribonuclease activity
QF06_09210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
QF06_09220	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
QF06_09225	COG1755	Isoprenylcysteine carboxyl methyltransferase
QF06_09230	COG3424	synthase
QF06_09235	COG2233	PERMEase
QF06_09240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
QF06_09245	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
QF06_09255	COG0800	Aldolase
QF06_09260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
QF06_09265	COG1609	Transcriptional regulator
QF06_09270	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
QF06_09275	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_09280	COG1199	ATP-dependent helicase activity
QF06_09290	COG0116	Belongs to the methyltransferase superfamily
QF06_09300	COG4474	Belongs to the UPF0398 family
QF06_09305	COG3359	exonuclease
QF06_09310	COG1111	helicase
QF06_09310	COG1205	dead DEAH box helicase
QF06_09315	COG2190	(PTS) system
QF06_09320	COG0071	Belongs to the small heat shock protein (HSP20) family
QF06_09355	COG3331	DNA recombination
QF06_09360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QF06_09360	COG4499	WXG100 protein secretion system (Wss), protein YukC
QF06_09370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
QF06_09375	COG3935	DnaD domain protein
QF06_09380	COG0017	Asparaginyl-tRNA synthetase
QF06_09385	COG0436	Aminotransferase
QF06_09390	COG5353	protein conserved in bacteria
QF06_09395	COG1199	ATP-dependent helicase activity
QF06_09395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
QF06_09400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
QF06_09405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
QF06_09410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
QF06_09415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
QF06_09415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
QF06_09420	COG0617	tRNA 3'-terminal CCA addition
QF06_09425	COG0438	transferase activity, transferring glycosyl groups
QF06_09430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
QF06_09435	COG1803	Methylglyoxal synthase
QF06_09440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
QF06_09445	COG1694	Mazg nucleotide pyrophosphohydrolase
QF06_09450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QF06_09460	COG4347	Protein of unknown function (DUF1405)
QF06_09465	COG2010	Cytochrome c
QF06_09465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
QF06_09470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
QF06_09475	COG0723	plastoquinol--plastocyanin reductase activity
QF06_09485	COG5582	Belongs to the UPF0302 family
QF06_09490	COG0457	Tetratricopeptide repeat
QF06_09495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
QF06_09500	COG0287	Prephenate dehydrogenase
QF06_09505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
QF06_09515	COG0133	tryptophan synthase activity
QF06_09520	COG0135	phosphoribosylanthranilate isomerase activity
QF06_09530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
QF06_09535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
QF06_09540	COG4401	Chorismate mutase type I
QF06_09545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
QF06_09550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
QF06_09555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
QF06_09560	COG0105	UTP biosynthetic process
QF06_09565	COG0142	geranyltranstransferase activity
QF06_09570	COG2226	methyltransferase
QF06_09575	COG0142	geranyltranstransferase activity
QF06_09585	COG0302	gtp cyclohydrolase
QF06_09590	COG0776	regulation of translation
QF06_09595	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
QF06_09610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
QF06_09615	COG1160	GTP binding
QF06_09635	COG1304	FMN binding
QF06_09640	COG0539	negative regulation of cytoplasmic translation
QF06_09645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
QF06_09650	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
QF06_09655	COG2959	enzyme of heme biosynthesis
QF06_09660	COG3409	Peptidoglycan-binding domain 1 protein
QF06_09660	COG3773	Cell wall hydrolase
QF06_09665	COG2339	peptidase activity
QF06_09670	COG0492	ferredoxin-NADP+ reductase activity
QF06_09675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
QF06_09680	COG4862	establishment of competence for transformation
QF06_09685	COG1408	metallophosphoesterase
QF06_09695	COG1388	LysM domain
QF06_09700	COG1266	CAAX protease self-immunity
QF06_09705	COG0514	ATP-dependent DNA helicase (RecQ)
QF06_09710	COG4955	Helix-turn-helix domain
QF06_09715	COG1141	Ferredoxin
QF06_09720	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
QF06_09725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
QF06_09730	COG0710	3-dehydroquinate dehydratase activity
QF06_09740	COG1595	DNA-templated transcription, initiation
QF06_09745	COG5002	protein histidine kinase activity
QF06_09750	COG0745	RESPONSE REGULATOR receiver
QF06_09755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
QF06_09760	COG1333	cytochrome c biogenesis protein
QF06_09765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_09770	COG1187	pseudouridine synthase activity
QF06_09775	COG0700	Nucleoside recognition
QF06_09780	COG2715	membrane protein required for spore maturation
QF06_09785	COG1686	Belongs to the peptidase S11 family
QF06_09795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
QF06_09800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
QF06_09805	COG1547	Domain of unknown function (DUF309)
QF06_09810	COG0456	acetyltransferase
QF06_09815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
QF06_09820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
QF06_09820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
QF06_09825	COG0307	riboflavin synthase, alpha
QF06_09830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
QF06_09830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
QF06_09840	COG0681	Belongs to the peptidase S26 family
QF06_09855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
QF06_09860	COG4086	secreted protein
QF06_09865	COG0019	diaminopimelate decarboxylase activity
QF06_09870	COG0697	spore germination
QF06_09885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
QF06_09905	COG1191	sigma factor activity
QF06_09910	COG2172	sigma factor antagonist activity
QF06_09915	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_09920	COG1686	Belongs to the peptidase S11 family
QF06_09925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
QF06_09930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
QF06_09935	COG4974	Belongs to the 'phage' integrase family
QF06_09945	COG0735	belongs to the Fur family
QF06_09950	COG1300	Membrane
QF06_09960	COG0281	malic enzyme
QF06_09965	COG1757	Na H antiporter
QF06_09970	COG1027	Aspartate ammonia-lyase
QF06_09975	COG0252	asparaginase activity
QF06_09980	COG1396	sequence-specific DNA binding
QF06_09985	COG1379	DNA repair
QF06_09990	COG0494	nUDIX hydrolase
QF06_10000	COG0667	Aldo Keto reductase
QF06_10010	COG1073	alpha beta
QF06_10020	COG4918	Iron-sulphur cluster biosynthesis
QF06_10025	COG0456	acetyltransferase
QF06_10025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
QF06_10030	COG2329	Antibiotic biosynthesis monooxygenase
QF06_10035	COG0456	acetyltransferase
QF06_10045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
QF06_10055	COG2211	Major facilitator Superfamily
QF06_10060	COG0346	lactoylglutathione lyase activity
QF06_10065	COG1072	(Pantothenic acid kinase))
QF06_10070	COG3048	D-serine ammonia-lyase activity
QF06_10075	COG0300	oxidoreductase activity
QF06_10080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_10085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
QF06_10090	COG4187	Peptidase family M20/M25/M40
QF06_10095	COG1902	pentaerythritol trinitrate reductase activity
QF06_10100	COG0596	Alpha beta hydrolase
QF06_10110	COG1234	tRNA 3'-trailer cleavage
QF06_10115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
QF06_10120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
QF06_10125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
QF06_10135	COG0706	membrane insertase activity
QF06_10140	COG3361	conserved protein (COG2071)
QF06_10145	COG2195	Cleaves the N-terminal amino acid of tripeptides
QF06_10150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
QF06_10155	COG0346	lactoylglutathione lyase activity
QF06_10160	COG1376	ErfK ybiS ycfS ynhG family protein
QF06_10165	COG4129	membrane
QF06_10170	COG1126	abc transporter atp-binding protein
QF06_10175	COG0765	amino acid transport
QF06_10180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QF06_10190	COG1597	lipid kinase activity
QF06_10195	COG2814	Major facilitator Superfamily
QF06_10200	COG4978	Transcriptional regulator
QF06_10200	COG0789	Transcriptional regulator
QF06_10205	COG0508	dehydrogenase complex catalyzes the overall conversion of
QF06_10210	COG0022	dehydrogenase e1 component
QF06_10215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
QF06_10220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
QF06_10225	COG3426	butyrate kinase activity
QF06_10230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
QF06_10235	COG0280	phosphate acetyltransferase
QF06_10240	COG3290	protein histidine kinase activity
QF06_10240	COG3829	transcription factor binding
QF06_10250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
QF06_10255	COG2079	MmgE PrpD family protein
QF06_10260	COG0372	Belongs to the citrate synthase family
QF06_10265	COG1960	acyl-CoA dehydrogenase activity
QF06_10270	COG1250	3-hydroxyacyl-CoA dehydrogenase
QF06_10275	COG0183	Belongs to the thiolase family
QF06_10280	COG0584	glycerophosphoryl diester phosphodiesterase
QF06_10285	COG0860	N-Acetylmuramoyl-L-alanine amidase
QF06_10295	COG1902	pentaerythritol trinitrate reductase activity
QF06_10300	COG0745	RESPONSE REGULATOR receiver
QF06_10305	COG0750	zinc metalloprotease
QF06_10310	COG0497	DNA recombination
QF06_10315	COG1438	arginine binding
QF06_10320	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
QF06_10325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
QF06_10330	COG0142	geranyltranstransferase activity
QF06_10335	COG1722	exodeoxyribonuclease VII activity
QF06_10340	COG1570	exodeoxyribonuclease VII activity
QF06_10345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
QF06_10350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
QF06_10355	COG1302	Protein conserved in bacteria
QF06_10360	COG0439	Biotin carboxylase
QF06_10365	COG0511	ligase activity, forming carbon-carbon bonds
QF06_10405	COG3854	ATPases associated with a variety of cellular activities
QF06_10415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
QF06_10420	COG0006	proline dipeptidase activity
QF06_10425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
QF06_10435	COG3872	metal-dependent enzyme
QF06_10445	COG1752	Esterase of the alpha-beta hydrolase superfamily
QF06_10450	COG1321	iron dependent repressor
QF06_10455	COG0095	Lipoate-protein ligase
QF06_10460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QF06_10465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
QF06_10470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
QF06_10475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
QF06_10480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
QF06_10495	COG1396	sequence-specific DNA binding
QF06_10505	COG0681	Belongs to the peptidase S26 family
QF06_10530	COG4940	Competence protein ComGF
QF06_10540	COG4970	Tfp pilus assembly protein FimT
QF06_10545	COG4537	Required for transformation and DNA binding
QF06_10550	COG1459	type II secretion system
QF06_10555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
QF06_10560	COG0598	Magnesium transport protein CorA
QF06_10565	COG1253	flavin adenine dinucleotide binding
QF06_10570	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_10580	COG1393	Belongs to the ArsC family
QF06_10590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_10600	COG0011	TIGRFAM Protein of
QF06_10610	COG2866	Carboxypeptidase
QF06_10615	COG1368	sulfuric ester hydrolase activity
QF06_10625	COG4483	Protein conserved in bacteria
QF06_10630	COG0705	Rhomboid family
QF06_10630	COG0457	Tetratricopeptide repeat
QF06_10635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
QF06_10640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
QF06_10645	COG0438	transferase activity, transferring glycosyl groups
QF06_10660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
QF06_10665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
QF06_10670	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
QF06_10675	COG0581	inorganic phosphate transmembrane transporter activity
QF06_10680	COG0573	inorganic phosphate transmembrane transporter activity
QF06_10685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
QF06_10695	COG0477	Major facilitator Superfamily
QF06_10700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
QF06_10705	COG2839	Protein conserved in bacteria
QF06_10710	COG5521	maltodextrose utilization protein MalA
QF06_10715	COG1388	LysM domain
QF06_10720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
QF06_10725	COG4709	membrane
QF06_10730	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
QF06_10735	COG0735	belongs to the Fur family
QF06_10740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QF06_10750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
QF06_10755	COG0513	Belongs to the DEAD box helicase family
QF06_10765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
QF06_10770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
QF06_10775	COG2384	SAM-dependent methyltransferase
QF06_10780	COG2010	Cytochrome c
QF06_10785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
QF06_10790	COG0358	DNA primase activity
QF06_10795	COG1671	Belongs to the UPF0178 family
QF06_10800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
QF06_10805	COG0517	IMP dehydrogenase activity
QF06_10810	COG0751	glycine-tRNA ligase activity
QF06_10815	COG0752	glycyl-tRNA synthetase alpha subunit
QF06_10820	COG1381	Involved in DNA repair and RecF pathway recombination
QF06_10825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
QF06_10830	COG0295	cytidine deaminase activity
QF06_10835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
QF06_10840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
QF06_10845	COG1480	7TM receptor with intracellular HD hydrolase
QF06_10850	COG1702	phosphate starvation-inducible protein PhoH
QF06_10855	COG0561	phosphatase activity
QF06_10870	COG4864	UPF0365 protein
QF06_10875	COG1030	water channel activity
QF06_10880	COG1610	YqeY-like protein
QF06_10885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
QF06_10890	COG1283	sodium-dependent phosphate transmembrane transporter activity
QF06_10895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
QF06_10900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
QF06_10905	COG2264	protein methyltransferase activity
QF06_10910	COG0484	heat shock protein binding
QF06_10915	COG0443	Heat shock 70 kDa protein
QF06_10920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
QF06_10925	COG1420	regulation of RNA biosynthetic process
QF06_10930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
QF06_10945	COG0860	N-Acetylmuramoyl-L-alanine amidase
QF06_10950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
QF06_10955	COG0268	Binds directly to 16S ribosomal RNA
QF06_10960	COG1466	dna polymerase III delta subunit
QF06_10970	COG2333	competence protein COMEC
QF06_10970	COG0658	competence protein
QF06_10975	COG2131	deaminase
QF06_10980	COG1596	polysaccharide export
QF06_10980	COG1555	photosystem II stabilization
QF06_10985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
QF06_10990	COG2226	methyltransferase
QF06_10995	COG0799	negative regulation of ribosome biogenesis
QF06_11000	COG1713	HD superfamily hydrolase involved in NAD metabolism
QF06_11005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
QF06_11010	COG1534	Rna-binding protein
QF06_11015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
QF06_11020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
QF06_11025	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
QF06_11035	COG2755	lipolytic protein G-D-S-L family
QF06_11040	COG3409	Peptidoglycan-binding domain 1 protein
QF06_11040	COG5632	N-Acetylmuramoyl-L-alanine amidase
QF06_11045	COG0398	Pfam SNARE associated Golgi protein
QF06_11050	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
QF06_11060	COG3209	COG3209 Rhs family protein
QF06_11070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
QF06_11075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
QF06_11080	COG0798	PFAM Bile acid sodium symporter
QF06_11085	COG0346	lactoylglutathione lyase activity
QF06_11090	COG0640	Transcriptional regulator
QF06_11095	COG3403	YqcI/YcgG family
QF06_11100	COG0457	Tetratricopeptide repeat
QF06_11110	COG5444	nuclease activity
QF06_11130	COG3409	Peptidoglycan-binding domain 1 protein
QF06_11130	COG5632	N-Acetylmuramoyl-L-alanine amidase
QF06_11135	COG4824	toxin secretion phage lysis holin
QF06_11165	COG3778	Protein conserved in bacteria
QF06_11170	COG3299	homolog of phage Mu protein gp47
QF06_11175	COG3628	GPW Gp25 family protein
QF06_11185	COG4193	domain, Protein
QF06_11190	COG1652	LysM domain
QF06_11195	COG5280	Phage tail tape measure protein TP901
QF06_11195	COG3953	SLT domain
QF06_11250	COG4653	Phage capsid family
QF06_11255	COG0338	D12 class N6 adenine-specific DNA methyltransferase
QF06_11265	COG2369	cell adhesion
QF06_11270	COG5518	Phage portal protein
QF06_11275	COG1783	phage Terminase large subunit
QF06_11280	COG5484	DNA packaging
QF06_11290	COG3677	Transposase
QF06_11305	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
QF06_11310	COG1484	DNA-dependent DNA replication
QF06_11315	COG3935	DnaD domain protein
QF06_11320	COG3723	Recombinational DNA repair protein, rece pathway
QF06_11325	COG5377	YqaJ viral recombinase family
QF06_11345	COG1476	TRANSCRIPTIONal
QF06_11350	COG3620	sequence-specific DNA binding
QF06_11355	COG0563	adenylate kinase activity
QF06_11360	COG2856	Zn peptidase
QF06_11370	COG3223	Belongs to the PsiE family
QF06_11375	COG5002	protein histidine kinase activity
QF06_11375	COG0642	Histidine kinase
QF06_11380	COG0745	RESPONSE REGULATOR receiver
QF06_11385	COG2311	Membrane
QF06_11390	COG0454	-acetyltransferase
QF06_11395	COG2249	NAD(P)H dehydrogenase (quinone) activity
QF06_11405	COG0730	response to heat
QF06_11410	COG0425	Belongs to the sulfur carrier protein TusA family
QF06_11415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_11415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QF06_11425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QF06_11425	COG0425	Belongs to the sulfur carrier protein TusA family
QF06_11430	COG2210	Belongs to the sulfur carrier protein TusA family
QF06_11435	COG1937	Protein conserved in bacteria
QF06_11440	COG0662	Cupin 2, conserved barrel domain protein
QF06_11445	COG0789	Transcriptional regulator
QF06_11445	COG4978	Transcriptional regulator
QF06_11450	COG2814	Major facilitator Superfamily
QF06_11455	COG0456	acetyltransferase
QF06_11460	COG1253	flavin adenine dinucleotide binding
QF06_11465	COG0697	spore germination
QF06_11470	COG0583	DNA-binding transcription factor activity
QF06_11475	COG2072	flavoprotein involved in K transport
QF06_11480	COG1230	cation diffusion facilitator family transporter
QF06_11485	COG1942	4-Oxalocrotonate Tautomerase
QF06_11490	COG0583	DNA-binding transcription factor activity
QF06_11500	COG1114	Component of the transport system for branched-chain amino acids
QF06_11505	COG1687	branched-chain amino acid
QF06_11510	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
QF06_11515	COG1522	sequence-specific DNA binding
QF06_11520	COG2732	(Barnase) inhibitor
QF06_11525	COG2124	cytochrome p450
QF06_11530	COG1335	isochorismatase
QF06_11540	COG2318	DinB family
QF06_11550	COG2070	2-Nitropropane dioxygenase
QF06_11555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
QF06_11565	COG2186	Transcriptional regulator
QF06_11575	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_11580	COG3958	Transketolase
QF06_11585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
QF06_11590	COG0477	Major facilitator Superfamily
QF06_11595	COG1846	Transcriptional regulator
QF06_11600	COG3443	Belongs to the bacterial solute-binding protein 9 family
QF06_11605	COG1595	DNA-templated transcription, initiation
QF06_11610	COG0667	Aldo Keto reductase
QF06_11615	COG2851	Citrate transporter
QF06_11620	COG0583	DNA-binding transcription factor activity
QF06_11625	COG2828	Protein conserved in bacteria
QF06_11630	COG3409	Peptidoglycan-binding domain 1 protein
QF06_11635	COG5566	PFAM Mor transcription activator
QF06_11640	COG0596	Alpha beta hydrolase
QF06_11645	COG4991	sh3 domain protein
QF06_11650	COG4991	sh3 domain protein
QF06_11655	COG0346	lactoylglutathione lyase activity
QF06_11665	COG5577	PFAM Coat F domain
QF06_11670	COG1063	alcohol dehydrogenase
QF06_11680	COG5577	PFAM Coat F domain
QF06_11685	COG0789	Transcriptional regulator
QF06_11695	COG1064	alcohol dehydrogenase
QF06_11700	COG0693	protein deglycase activity
QF06_11705	COG1621	beta-fructofuranosidase activity
QF06_11710	COG3716	PTS system mannose fructose sorbose family IID component
QF06_11715	COG3715	PTS system
QF06_11720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_11725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_11730	COG3933	PFAM sigma-54 factor interaction domain-containing protein
QF06_11730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
QF06_11735	COG1113	amino acid transport
QF06_11740	COG1280	lysine exporter protein (LysE YggA)
QF06_11745	COG1378	Sugar-specific transcriptional regulator TrmB
QF06_11750	COG1595	DNA-templated transcription, initiation
QF06_11760	COG2755	lipolytic protein G-D-S-L family
QF06_11760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
QF06_11770	COG2124	cytochrome p450
QF06_11770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
QF06_11775	COG1309	transcriptional regulator
QF06_11780	COG2226	methyltransferase
QF06_11790	COG2116	formate transmembrane transporter activity
QF06_11795	COG5609	conserved protein (DUF2294)
QF06_11800	COG3383	formate dehydrogenase (NAD+) activity
QF06_11805	COG2427	Protein of unknown function (DUF1641)
QF06_11815	COG0626	cystathionine gamma-synthase activity
QF06_11820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
QF06_11825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
QF06_11830	COG2226	methyltransferase
QF06_11845	COG0768	penicillin binding
QF06_11850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
QF06_11855	COG0572	uridine kinase
QF06_11875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
QF06_11880	COG3906	Belongs to the UPF0473 family
QF06_11885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
QF06_11890	COG4472	Bacterial protein of unknown function (DUF965)
QF06_11895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
QF06_11900	COG0628	permease
QF06_11905	COG1126	abc transporter atp-binding protein
QF06_11910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QF06_11915	COG0765	amino acid transport
QF06_11920	COG0765	amino acid transport
QF06_11930	COG3881	PFAM PRC-barrel domain
QF06_11935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
QF06_11940	COG0457	Tetratricopeptide repeat
QF06_11945	COG0482	sulfurtransferase activity
QF06_11950	COG1104	cysteine desulfurase activity
QF06_11955	COG1959	2 iron, 2 sulfur cluster binding
QF06_11960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
QF06_11965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
QF06_11970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
QF06_11975	COG0124	histidyl-tRNA synthetase
QF06_11980	COG3103	Sh3 type 3 domain protein
QF06_11980	COG0860	N-Acetylmuramoyl-L-alanine amidase
QF06_11980	COG4991	sh3 domain protein
QF06_11985	COG1490	D-aminoacyl-tRNA deacylase activity
QF06_11990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
QF06_11995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
QF06_12000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
QF06_12000	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
QF06_12005	COG5416	Lipopolysaccharide assembly protein A domain
QF06_12010	COG0490	domain, Protein
QF06_12015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
QF06_12015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
QF06_12025	COG2244	polysaccharide biosynthetic process
QF06_12030	COG2323	membrane
QF06_12040	COG1862	Preprotein translocase
QF06_12045	COG0343	queuine tRNA-ribosyltransferase activity
QF06_12050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
QF06_12060	COG2255	four-way junction helicase activity
QF06_12065	COG0632	four-way junction helicase activity
QF06_12075	COG2814	Major facilitator Superfamily
QF06_12080	COG0673	inositol 2-dehydrogenase activity
QF06_12085	COG2112	serine threonine protein kinase
QF06_12100	COG1115	amino acid carrier protein
QF06_12105	COG0217	transcriptional regulatory protein
QF06_12115	COG1388	LysM domain
QF06_12120	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
QF06_12125	COG0157	Belongs to the NadC ModD family
QF06_12130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
QF06_12135	COG1104	cysteine desulfurase activity
QF06_12140	COG1827	regulation of RNA biosynthetic process
QF06_12145	COG0077	Prephenate dehydratase
QF06_12150	COG4492	Belongs to the UPF0735 family
QF06_12155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
QF06_12160	COG3290	protein histidine kinase activity
QF06_12165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
QF06_12170	COG2868	ribosomal protein
QF06_12175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
QF06_12180	COG1994	Peptidase M50
QF06_12185	COG0739	heme binding
QF06_12190	COG2894	cell division
QF06_12195	COG0850	regulation of cytokinetic process
QF06_12200	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
QF06_12205	COG1792	Involved in formation and maintenance of cell shape
QF06_12210	COG1077	Cell shape determining protein MreB Mrl
QF06_12215	COG2003	Belongs to the UPF0758 family
QF06_12220	COG0424	maF-like protein
QF06_12230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
QF06_12235	COG0285	dihydrofolate synthase activity
QF06_12240	COG0525	valine-tRNA ligase activity
QF06_12250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QF06_12255	COG1388	LysM domain
QF06_12260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
QF06_12265	COG0113	porphobilinogen synthase activity
QF06_12270	COG1587	Uroporphyrinogen-III synthase
QF06_12275	COG0181	hydroxymethylbilane synthase activity
QF06_12280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
QF06_12285	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
QF06_12295	COG0218	Necessary for normal cell division and for the maintenance of normal septation
QF06_12300	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
QF06_12305	COG1067	ATP-dependent peptidase activity
QF06_12305	COG0470	DNA polymerase III
QF06_12310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
QF06_12315	COG0544	peptidyl-prolyl cis-trans isomerase activity
QF06_12320	COG1477	protein flavinylation
QF06_12320	COG0457	Tetratricopeptide repeat
QF06_12325	COG0066	3-isopropylmalate dehydratase activity
QF06_12330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
QF06_12335	COG0473	3-isopropylmalate dehydrogenase activity
QF06_12340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
QF06_12345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
QF06_12350	COG0440	acetolactate synthase activity
QF06_12355	COG0028	Belongs to the TPP enzyme family
QF06_12365	COG0454	-acetyltransferase
QF06_12370	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
QF06_12380	COG0622	Phosphoesterase
QF06_12385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
QF06_12390	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
QF06_12395	COG5401	PFAM Sporulation and spore germination
QF06_12400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
QF06_12405	COG1846	Transcriptional regulator
QF06_12410	COG2197	response regulator
QF06_12415	COG0824	Thioesterase
QF06_12420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
QF06_12425	COG1053	succinate dehydrogenase
QF06_12430	COG2009	succinate dehydrogenase
QF06_12435	COG1719	4-vinyl reductase, 4VR
QF06_12440	COG0527	aspartate kinase activity
QF06_12445	COG0322	excinuclease ABC activity
QF06_12450	COG3118	belongs to the thioredoxin family
QF06_12455	COG3534	alpha-L-arabinofuranosidase
QF06_12460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
QF06_12465	COG2086	electron transfer activity
QF06_12470	COG1024	Enoyl-CoA hydratase
QF06_12475	COG1309	transcriptional regulator
QF06_12480	COG0318	PFAM AMP-dependent synthetase and ligase
QF06_12485	COG3766	membrane
QF06_12490	COG1193	negative regulation of DNA recombination
QF06_12495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
QF06_12495	COG1796	DNA polymerase
QF06_12500	COG1286	toxin biosynthetic process
QF06_12505	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
QF06_12510	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
QF06_12515	COG0072	phenylalanine-tRNA ligase activity
QF06_12515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QF06_12520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
QF06_12530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
QF06_12540	COG3835	regulator
QF06_12545	COG0277	FAD linked oxidase domain protein
QF06_12550	COG0247	lactate metabolic process
QF06_12555	COG0346	lactoylglutathione lyase activity
QF06_12560	COG1966	Carbon starvation protein
QF06_12565	COG3534	alpha-L-arabinofuranosidase
QF06_12570	COG0395	ABC-type sugar transport system, permease component
QF06_12575	COG1175	transmembrane transport
QF06_12580	COG1653	transport
QF06_12585	COG0371	Dehydrogenase
QF06_12590	COG0647	UMP catabolic process
QF06_12595	COG0235	Class ii aldolase
QF06_12600	COG1069	ribulokinase activity
QF06_12605	COG2160	L-arabinose isomerase activity
QF06_12610	COG3507	Belongs to the glycosyl hydrolase 43 family
QF06_12615	COG1363	Peptidase, m42
QF06_12625	COG3326	Membrane
QF06_12630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
QF06_12635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
QF06_12640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
QF06_12650	COG1346	cytolysis
QF06_12655	COG1380	Effector of murein hydrolase LrgA
QF06_12660	COG3279	Response regulator of the LytR AlgR family
QF06_12665	COG3275	phosphorelay sensor kinase activity
QF06_12675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
QF06_12685	COG0398	Pfam SNARE associated Golgi protein
QF06_12690	COG1484	DNA-dependent DNA replication
QF06_12695	COG3611	Membrane attachment protein
QF06_12700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
QF06_12705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
QF06_12710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
QF06_12715	COG1733	regulation of RNA biosynthetic process
QF06_12720	COG2814	Major facilitator Superfamily
QF06_12725	COG0656	L-ascorbic acid biosynthetic process
QF06_12730	COG0237	dephospho-CoA kinase activity
QF06_12735	COG1971	Probably functions as a manganese efflux pump
QF06_12740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
QF06_12745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
QF06_12745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
QF06_12750	COG5002	protein histidine kinase activity
QF06_12755	COG0745	RESPONSE REGULATOR receiver
QF06_12760	COG0039	L-malate dehydrogenase activity
QF06_12765	COG0538	isocitrate dehydrogenase activity
QF06_12770	COG0372	Belongs to the citrate synthase family
QF06_12775	COG2707	UPF0756 membrane protein
QF06_12780	COG0628	permease
QF06_12785	COG3030	protein affecting phage T7 exclusion by the F plasmid
QF06_12790	COG0469	pyruvate kinase activity
QF06_12795	COG0205	6-phosphofructokinase activity
QF06_12800	COG0825	malonyl-CoA metabolic process
QF06_12805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
QF06_12810	COG0281	malic enzyme
QF06_12815	COG0587	DNA-directed DNA polymerase activity
QF06_12835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
QF06_12845	COG4109	DRTGG domain
QF06_12850	COG0730	response to heat
QF06_12855	COG1473	amidohydrolase
QF06_12860	COG0196	riboflavin kinase activity
QF06_12865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QF06_12870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
QF06_12875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QF06_12880	COG1126	abc transporter atp-binding protein
QF06_12885	COG0765	amino acid transport
QF06_12890	COG0765	amino acid transport
QF06_12895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QF06_12900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QF06_12905	COG0454	-acetyltransferase
QF06_12910	COG0583	DNA-binding transcription factor activity
QF06_12915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
QF06_12920	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_12925	COG0165	Argininosuccinate lyase
QF06_12930	COG0137	argininosuccinate synthase activity
QF06_12935	COG0521	Mo-molybdopterin cofactor biosynthetic process
QF06_12940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
QF06_12945	COG0827	DNA restriction-modification system
QF06_12950	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
QF06_12955	COG3874	Sporulation protein YtfJ
QF06_12965	COG1714	RDD family
QF06_12970	COG0616	signal peptide processing
QF06_12975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
QF06_12980	COG1574	metal-dependent hydrolase with the TIM-barrel fold
QF06_12985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
QF06_12995	COG0301	tRNA thio-modification
QF06_13000	COG1104	cysteine desulfurase activity
QF06_13005	COG1114	Component of the transport system for branched-chain amino acids
QF06_13010	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
QF06_13015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
QF06_13020	COG1309	transcriptional regulator
QF06_13025	COG1956	GAF domain-containing protein
QF06_13030	COG2199	diguanylate cyclase activity
QF06_13030	COG2203	Gaf domain
QF06_13035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
QF06_13040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
QF06_13045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
QF06_13050	COG0454	-acetyltransferase
QF06_13055	COG0517	IMP dehydrogenase activity
QF06_13060	COG0123	including yeast histone deacetylase and acetoin utilization protein
QF06_13065	COG1360	Flagellar Motor Protein
QF06_13070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
QF06_13075	COG1609	Transcriptional regulator
QF06_13080	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
QF06_13080	COG1605	Chorismate mutase
QF06_13085	COG3118	belongs to the thioredoxin family
QF06_13090	COG4980	gas vesicle protein
QF06_13095	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
QF06_13100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
QF06_13105	COG1674	ftsk spoiiie
QF06_13110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QF06_13115	COG4848	Belongs to the UPF0354 family
QF06_13120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_13130	COG1363	Peptidase, m42
QF06_13135	COG5584	Small secreted protein
QF06_13140	COG0281	malic enzyme
QF06_13145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_13150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
QF06_13160	COG0510	thiamine kinase activity
QF06_13165	COG1523	belongs to the glycosyl hydrolase 13 family
QF06_13170	COG1597	lipid kinase activity
QF06_13180	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
QF06_13185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
QF06_13190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
QF06_13195	COG2252	PERMEase
QF06_13200	COG4473	ABC transporter
QF06_13205	COG1131	(ABC) transporter
QF06_13210	COG1349	DNA-binding transcription factor activity
QF06_13215	COG1187	pseudouridine synthase activity
QF06_13220	COG2244	polysaccharide biosynthetic process
QF06_13225	COG2081	HI0933 family
QF06_13230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
QF06_13240	COG5578	integral membrane protein
QF06_13245	COG0673	inositol 2-dehydrogenase activity
QF06_13250	COG1653	transport
QF06_13255	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
QF06_13260	COG4209	transmembrane transport
QF06_13265	COG2207	Transcriptional regulator
QF06_13270	COG1653	transport
QF06_13275	COG0395	ABC-type sugar transport system, permease component
QF06_13280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
QF06_13285	COG2124	cytochrome p450
QF06_13290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
QF06_13300	COG0156	8-amino-7-oxononanoate synthase activity
QF06_13305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
QF06_13315	COG1073	alpha beta
QF06_13340	COG1486	melibiose metabolic process
QF06_13345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
QF06_13350	COG0495	leucyl-tRNA aminoacylation
QF06_13360	COG1366	Belongs to the anti-sigma-factor antagonist family
QF06_13360	COG2202	Pas domain
QF06_13365	COG2814	Major facilitator Superfamily
QF06_13370	COG2433	Pfam Transposase IS66
QF06_13375	COG0577	efflux transmembrane transporter activity
QF06_13380	COG1136	(ABC) transporter
QF06_13385	COG2205	protein histidine kinase activity
QF06_13390	COG0745	RESPONSE REGULATOR receiver
QF06_13395	COG0577	efflux transmembrane transporter activity
QF06_13400	COG1136	(ABC) transporter
QF06_13415	COG1131	(ABC) transporter
QF06_13420	COG1725	Transcriptional regulator
QF06_13430	COG1242	4 iron, 4 sulfur cluster binding
QF06_13435	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
QF06_13445	COG2267	carboxylic ester hydrolase activity
QF06_13450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
QF06_13455	COG1113	amino acid transport
QF06_13460	COG0367	asparagine synthase
QF06_13465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
QF06_13470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
QF06_13480	COG1506	peptidase
QF06_13485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
QF06_13490	COG1116	anion transmembrane transporter activity
QF06_13495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
QF06_13500	COG0494	nUDIX hydrolase
QF06_13505	COG4824	toxin secretion phage lysis holin
QF06_13510	COG0783	Belongs to the Dps family
QF06_13525	COG1854	S-ribosylhomocysteine lyase activity
QF06_13530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
QF06_13535	COG0288	reversible hydration of carbon dioxide
QF06_13540	COG0254	rRNA binding
QF06_13545	COG1271	oxidase subunit
QF06_13550	COG1294	oxidase, subunit
QF06_13555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
QF06_13560	COG1321	iron dependent repressor
QF06_13560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
QF06_13565	COG1121	(ABC) transporter
QF06_13570	COG0803	Belongs to the bacterial solute-binding protein 9 family
QF06_13575	COG4948	Mandelate Racemase Muconate Lactonizing
QF06_13580	COG0318	PFAM AMP-dependent synthetase and ligase
QF06_13585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
QF06_13590	COG0596	Alpha beta hydrolase
QF06_13595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
QF06_13600	COG1169	isochorismate synthase
QF06_13605	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
QF06_13610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
QF06_13615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
QF06_13620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
QF06_13625	COG0438	transferase activity, transferring glycosyl groups
QF06_13635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QF06_13640	COG0438	transferase activity, transferring glycosyl groups
QF06_13645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QF06_13650	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
QF06_13655	COG0058	SHG alpha-glucan phosphorylase activity
QF06_13660	COG0297	glycogen (starch) synthase activity
QF06_13665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
QF06_13670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
QF06_13675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
QF06_13800	COG3859	Proton-coupled thiamine transporter YuaJ
QF06_13805	COG1247	-acetyltransferase
QF06_13810	COG2268	Band 7 protein
QF06_13815	COG1585	Membrane protein implicated in regulation of membrane protease activity
QF06_13820	COG2318	DinB family
QF06_13830	COG1454	alcohol dehydrogenase
QF06_13840	COG1510	regulation of RNA biosynthetic process
QF06_13850	COG0569	domain protein
QF06_13855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
QF06_13860	COG4682	membrane
QF06_13865	COG1705	Flagellar rod assembly protein muramidase FlgJ
QF06_13870	COG0477	Major facilitator Superfamily
QF06_13875	COG5553	Cysteine dioxygenase type I
QF06_13885	COG1968	undecaprenyl-diphosphatase activity
QF06_13890	COG0628	permease
QF06_13895	COG0673	inositol 2-dehydrogenase activity
QF06_13900	COG4806	L-rhamnose isomerase
QF06_13905	COG3254	rhamnose metabolic process
QF06_13910	COG1070	Carbohydrate kinase
QF06_13915	COG1349	DNA-binding transcription factor activity
QF06_13920	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_13920	COG3347	Dehydrogenase
QF06_13925	COG0840	transmembrane signaling receptor activity
QF06_13930	COG0840	transmembrane signaling receptor activity
QF06_13935	COG0840	transmembrane signaling receptor activity
QF06_13940	COG0840	transmembrane signaling receptor activity
QF06_13955	COG0432	Pfam Uncharacterised protein family UPF0047
QF06_13960	COG0366	Alpha amylase catalytic
QF06_13965	COG1253	flavin adenine dinucleotide binding
QF06_13970	COG2738	Putative neutral zinc metallopeptidase
QF06_13985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
QF06_14000	COG0166	Belongs to the GPI family
QF06_14005	COG1979	alcohol dehydrogenase
QF06_14010	COG1979	alcohol dehydrogenase
QF06_14015	COG2155	Conserved Protein
QF06_14020	COG1098	S1 RNA binding domain
QF06_14025	COG0436	Aminotransferase
QF06_14030	COG1522	sequence-specific DNA binding
QF06_14035	COG2267	carboxylic ester hydrolase activity
QF06_14045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
QF06_14050	COG2205	protein histidine kinase activity
QF06_14060	COG5018	Exonuclease
QF06_14070	COG2814	Major facilitator Superfamily
QF06_14075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QF06_14080	COG3011	Protein conserved in bacteria
QF06_14090	COG3290	protein histidine kinase activity
QF06_14095	COG4565	transcriptional regulatory protein
QF06_14120	COG3493	citrate carrier protein
QF06_14130	COG2111	Na H antiporter
QF06_14130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
QF06_14135	COG2111	Na H antiporter
QF06_14140	COG1006	Multisubunit Na H antiporter MnhC subunit
QF06_14145	COG0651	ATP synthesis coupled electron transport
QF06_14150	COG1863	multisubunit Na H antiporter MnhE subunit
QF06_14155	COG2212	antiporter activity
QF06_14160	COG1320	monovalent cation:proton antiporter activity
QF06_14165	COG2050	protein possibly involved in aromatic compounds catabolism
QF06_14170	COG2197	response regulator
QF06_14175	COG4585	Histidine kinase
QF06_14185	COG0142	geranyltranstransferase activity
QF06_14205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
QF06_14210	COG1335	isochorismatase
QF06_14215	COG5506	Protein of unknown function (DUF1694)
QF06_14230	COG0628	permease
QF06_14245	COG1418	mRNA catabolic process
QF06_14250	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_14260	COG1511	domain protein
QF06_14265	COG0433	COG0433 Predicted ATPase
QF06_14265	COG1674	ftsk spoiiie
QF06_14270	COG4499	WXG100 protein secretion system (Wss), protein YukC
QF06_14275	COG5417	Belongs to the EsaB family
QF06_14280	COG4842	Belongs to the WXG100 family
QF06_14285	COG2508	Transcriptional regulator
QF06_14285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
QF06_14290	COG0686	Belongs to the AlaDH PNT family
QF06_14295	COG5634	Uncharacterized conserved protein (DUF2278)
QF06_14300	COG3251	PFAM MbtH domain protein
QF06_14305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_14310	COG1535	isochorismatase
QF06_14310	COG3433	isochorismatase activity
QF06_14315	COG1021	2,3-dihydroxybenzoate-AMP ligase
QF06_14320	COG1169	isochorismate synthase
QF06_14325	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_14330	COG2819	hydrolase of the alpha beta superfamily
QF06_14335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
QF06_14340	COG1268	BioY protein
QF06_14345	COG2056	Na+-H+ antiporter family
QF06_14350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
QF06_14355	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
QF06_14360	COG3584	3D domain protein
QF06_14370	COG1252	NADH dehydrogenase
QF06_14375	COG0492	ferredoxin-NADP+ reductase activity
QF06_14380	COG0516	GMP reductase activity
QF06_14385	COG2808	Putative FMN-binding domain
QF06_14390	COG0456	acetyltransferase
QF06_14395	COG0316	Belongs to the HesB IscA family
QF06_14400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
QF06_14405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
QF06_14410	COG4844	belongs to the
QF06_14415	COG1252	NADH dehydrogenase
QF06_14420	COG4837	Protein of unknown function (DUF1462)
QF06_14425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
QF06_14430	COG1506	peptidase
QF06_14430	COG0823	Involved in the tonB-independent uptake of proteins
QF06_14430	COG4946	Tricorn protease homolog
QF06_14435	COG0083	homoserine kinase activity
QF06_14440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
QF06_14445	COG0460	homoserine dehydrogenase
QF06_14450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
QF06_14455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
QF06_14460	COG0647	UMP catabolic process
QF06_14465	COG2445	Protein of unknown function DUF86
QF06_14470	COG4470	Protein conserved in bacteria
QF06_14480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
QF06_14485	COG0739	heme binding
QF06_14495	COG3377	Domain of unknown function (DUF1805)
QF06_14500	COG0737	Belongs to the 5'-nucleotidase family
QF06_14505	COG0730	response to heat
QF06_14510	COG1801	Protein of unknown function DUF72
QF06_14520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
QF06_14525	COG2508	Transcriptional regulator
QF06_14530	COG2233	PERMEase
QF06_14535	COG2233	PERMEase
QF06_14540	COG3195	allantoin biosynthetic process
QF06_14540	COG3648	Uricase
QF06_14545	COG2351	hydroxyisourate hydrolase activity
QF06_14555	COG2080	2 iron, 2 sulfur cluster binding
QF06_14560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
QF06_14565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
QF06_14570	COG2068	MobA-Related Protein
QF06_14575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
QF06_14580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
QF06_14585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
QF06_14590	COG2356	endonuclease I
QF06_14595	COG3842	ATPase activity
QF06_14600	COG2188	Transcriptional regulator
QF06_14605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
QF06_14610	COG0395	ABC-type sugar transport system, permease component
QF06_14615	COG1175	transmembrane transport
QF06_14620	COG1653	transport
QF06_14625	COG2222	sugar isomerase
QF06_14630	COG0322	excinuclease ABC activity
QF06_14635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
QF06_14650	COG0346	lactoylglutathione lyase activity
QF06_14655	COG0640	Transcriptional regulator
QF06_14660	COG0719	Fe-S assembly protein
QF06_14665	COG0822	iron-sulfur transferase activity
QF06_14670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
QF06_14675	COG0719	Fe-S assembly protein
QF06_14680	COG0396	ATPase activity
QF06_14685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
QF06_14690	COG1464	Belongs to the NlpA lipoprotein family
QF06_14695	COG2011	ABC-type metal ion transport system permease component
QF06_14700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
QF06_14710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
QF06_14715	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
QF06_14725	COG0509	glycine decarboxylation via glycine cleavage system
QF06_14730	COG1393	Belongs to the ArsC family
QF06_14735	COG1960	acyl-CoA dehydrogenase activity
QF06_14740	COG0183	Belongs to the thiolase family
QF06_14745	COG1024	Enoyl-CoA hydratase
QF06_14745	COG1250	3-hydroxyacyl-CoA dehydrogenase
QF06_14750	COG0506	proline dehydrogenase activity
QF06_14760	COG5577	PFAM Coat F domain
QF06_14765	COG1846	Transcriptional regulator
QF06_14770	COG0477	Major facilitator Superfamily
QF06_14775	COG1942	4-Oxalocrotonate Tautomerase
QF06_14780	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_14785	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_14790	COG0583	DNA-binding transcription factor activity
QF06_14800	COG1120	ATPase activity
QF06_14815	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_14820	COG0783	Belongs to the Dps family
QF06_14825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QF06_14830	COG0745	RESPONSE REGULATOR receiver
QF06_14835	COG2205	protein histidine kinase activity
QF06_14835	COG2770	Histidine kinase
QF06_14840	COG1309	transcriptional regulator
QF06_14845	COG0114	fumarate hydratase activity
QF06_14855	COG0697	spore germination
QF06_14860	COG0814	amino acid
QF06_14870	COG2197	response regulator
QF06_14875	COG4585	Histidine kinase
QF06_14880	COG4758	membrane
QF06_14885	COG3595	metallopeptidase activity
QF06_14890	COG1842	Phage shock protein A
QF06_14895	COG4758	membrane
QF06_14900	COG2814	Major facilitator Superfamily
QF06_14905	COG2096	Adenosyltransferase
QF06_14910	COG1120	ATPase activity
QF06_14915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_14920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QF06_14925	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_14930	COG3386	PFAM SMP-30 Gluconolaconase
QF06_14935	COG2205	protein histidine kinase activity
QF06_14940	COG0745	RESPONSE REGULATOR receiver
QF06_14950	COG1191	sigma factor activity
QF06_14955	COG2140	Oxalate decarboxylase
QF06_14965	COG0577	efflux transmembrane transporter activity
QF06_14970	COG1136	(ABC) transporter
QF06_14975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
QF06_14980	COG1120	ATPase activity
QF06_14985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_14990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_14995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QF06_15005	COG0531	amino acid
QF06_15015	COG1988	membrane-bound metal-dependent
QF06_15020	COG1368	sulfuric ester hydrolase activity
QF06_15025	COG1910	domain protein
QF06_15030	COG0725	ABC transporter, periplasmic molybdate-binding protein
QF06_15035	COG4149	molybdate abc transporter
QF06_15040	COG0656	L-ascorbic acid biosynthetic process
QF06_15050	COG0025	NhaP-type Na H and K H
QF06_15055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
QF06_15060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
QF06_15065	COG3973	AAA domain
QF06_15075	COG2860	membrane
QF06_15080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
QF06_15085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
QF06_15090	COG2217	Heavy metal translocating P-type atpase
QF06_15095	COG2217	Heavy metal translocating P-type atpase
QF06_15100	COG2608	mercury ion transmembrane transporter activity
QF06_15105	COG1937	Protein conserved in bacteria
QF06_15110	COG0673	inositol 2-dehydrogenase activity
QF06_15115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
QF06_15120	COG1289	transmembrane transporter activity
QF06_15130	COG2076	Multidrug Resistance protein
QF06_15135	COG1309	transcriptional regulator
QF06_15140	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_15155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
QF06_15160	COG0557	exoribonuclease II activity
QF06_15165	COG1647	Serine aminopeptidase, S33
QF06_15170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
QF06_15175	COG0596	Alpha beta hydrolase
QF06_15180	COG1476	TRANSCRIPTIONal
QF06_15185	COG1396	sequence-specific DNA binding
QF06_15190	COG1396	sequence-specific DNA binding
QF06_15195	COG1733	regulation of RNA biosynthetic process
QF06_15200	COG0840	transmembrane signaling receptor activity
QF06_15255	COG1174	glycine betaine transport
QF06_15260	COG1732	Glycine betaine
QF06_15265	COG1174	glycine betaine transport
QF06_15270	COG1125	glycine betaine transport
QF06_15270	COG0517	IMP dehydrogenase activity
QF06_15275	COG1510	regulation of RNA biosynthetic process
QF06_15280	COG1174	glycine betaine transport
QF06_15285	COG1732	Glycine betaine
QF06_15290	COG1174	glycine betaine transport
QF06_15295	COG1125	glycine betaine transport
QF06_15295	COG0517	IMP dehydrogenase activity
QF06_15300	COG1510	regulation of RNA biosynthetic process
QF06_15305	COG2095	MarC family integral membrane protein
QF06_15315	COG3064	Membrane
QF06_15320	COG4640	response to antibiotic
QF06_15325	COG0456	acetyltransferase
QF06_15330	COG0148	phosphopyruvate hydratase activity
QF06_15335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
QF06_15340	COG0149	triose-phosphate isomerase activity
QF06_15345	COG0126	phosphoglycerate kinase activity
QF06_15350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
QF06_15355	COG2390	Transcriptional regulator
QF06_15360	COG2814	Major facilitator Superfamily
QF06_15365	COG1609	Transcriptional regulator
QF06_15370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QF06_15375	COG0583	DNA-binding transcription factor activity
QF06_15380	COG0697	spore germination
QF06_15385	COG1113	amino acid transport
QF06_15390	COG3858	chitin binding
QF06_15395	COG1556	Lactate utilization protein
QF06_15400	COG1139	Iron-sulfur cluster binding protein
QF06_15405	COG0247	lactate metabolic process
QF06_15410	COG2197	response regulator
QF06_15415	COG4585	Histidine kinase
QF06_15420	COG0842	Transport permease protein
QF06_15425	COG1131	(ABC) transporter
QF06_15430	COG0596	Alpha beta hydrolase
QF06_15435	COG2208	phosphoserine phosphatase activity
QF06_15440	COG3867	Arabinogalactan endo-beta-1,4-galactanase
QF06_15445	COG1874	Beta-galactosidase
QF06_15450	COG3833	ABC-type maltose transport systems, permease component
QF06_15455	COG1175	transmembrane transport
QF06_15460	COG2182	Extracellular solute-binding protein
QF06_15465	COG1609	Transcriptional regulator
QF06_15470	COG2186	Transcriptional regulator
QF06_15475	COG1620	l-lactate permease
QF06_15480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
QF06_15490	COG5039	Polysaccharide pyruvyl transferase
QF06_15495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
QF06_15500	COG0110	maltose O-acetyltransferase activity
QF06_15505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
QF06_15510	COG2244	polysaccharide biosynthetic process
QF06_15515	COG1216	Glycosyl transferase, family 2
QF06_15520	COG5039	Polysaccharide pyruvyl transferase
QF06_15525	COG1216	Glycosyl transferase, family 2
QF06_15535	COG0438	transferase activity, transferring glycosyl groups
QF06_15540	COG1215	transferase activity, transferring glycosyl groups
QF06_15545	COG0438	transferase activity, transferring glycosyl groups
QF06_15550	COG1086	Polysaccharide biosynthesis protein
QF06_15555	COG0489	protein tyrosine kinase activity
QF06_15560	COG3944	biosynthesis protein
QF06_15565	COG1396	sequence-specific DNA binding
QF06_15570	COG2272	Belongs to the type-B carboxylesterase lipase family
QF06_15580	COG3479	Phenolic acid decarboxylase
QF06_15590	COG1794	racemase activity, acting on amino acids and derivatives
QF06_15595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
QF06_15600	COG1621	beta-fructofuranosidase activity
QF06_15605	COG1621	beta-fructofuranosidase activity
QF06_15610	COG0531	amino acid
QF06_15615	COG1309	transcriptional regulator
QF06_15620	COG2076	Multidrug Resistance protein
QF06_15625	COG2076	Multidrug Resistance protein
QF06_15640	COG0740	serine-type endopeptidase activity
QF06_15645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
QF06_15650	COG0366	Alpha amylase catalytic
QF06_15655	COG1554	hydrolase, family 65, central catalytic
QF06_15660	COG5521	maltodextrose utilization protein MalA
QF06_15665	COG3833	ABC-type maltose transport systems, permease component
QF06_15670	COG1175	transmembrane transport
QF06_15675	COG2182	Extracellular solute-binding protein
QF06_15680	COG0366	Alpha amylase catalytic
QF06_15685	COG1609	Transcriptional regulator
QF06_15690	COG1611	Belongs to the LOG family
QF06_15695	COG1694	Mazg nucleotide pyrophosphohydrolase
QF06_15700	COG0659	secondary active sulfate transmembrane transporter activity
QF06_15705	COG0288	reversible hydration of carbon dioxide
QF06_15710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
QF06_15715	COG0577	efflux transmembrane transporter activity
QF06_15720	COG1136	(ABC) transporter
QF06_15725	COG5002	protein histidine kinase activity
QF06_15730	COG0745	RESPONSE REGULATOR receiver
QF06_15750	COG2162	N-hydroxyarylamine O-acetyltransferase activity
QF06_15755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_15760	COG1481	regulation of sporulation
QF06_15765	COG0391	Required for morphogenesis under gluconeogenic growth conditions
QF06_15770	COG1660	Displays ATPase and GTPase activities
QF06_15775	COG1051	belongs to the nudix hydrolase family
QF06_15780	COG0492	ferredoxin-NADP+ reductase activity
QF06_15785	COG3883	PFAM NLP P60 protein
QF06_15785	COG0791	NLP P60 protein
QF06_15790	COG0457	Tetratricopeptide repeat
QF06_15795	COG1132	(ABC) transporter
QF06_15815	COG0140	phosphoribosyl-ATP diphosphatase activity
QF06_15815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
QF06_15820	COG0107	imidazoleglycerol-phosphate synthase activity
QF06_15825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
QF06_15830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
QF06_15835	COG0131	Imidazoleglycerol-phosphate dehydratase
QF06_15840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
QF06_15845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
QF06_15850	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
QF06_15855	COG4990	cell redox homeostasis
QF06_15860	COG5297	Belongs to the glycosyl hydrolase family 6
QF06_15865	COG0110	maltose O-acetyltransferase activity
QF06_15870	COG0546	phosphoglycolate phosphatase activity
QF06_15875	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
QF06_15880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
QF06_15885	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
QF06_15890	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
QF06_15895	COG0363	glucosamine-6-phosphate deaminase activity
QF06_15905	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
QF06_15910	COG1846	Transcriptional regulator
QF06_15925	COG1846	Transcriptional regulator
QF06_15930	COG2814	Major facilitator Superfamily
QF06_15935	COG1950	PFAM Membrane protein of
QF06_15940	COG1983	PspC domain protein
QF06_15945	COG3595	metallopeptidase activity
QF06_15960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
QF06_15965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
QF06_15970	COG0556	nucleotide-excision repair
QF06_15975	COG4897	Protein conserved in bacteria
QF06_15980	COG0574	Belongs to the PEP-utilizing enzyme family
QF06_15980	COG3848	Pyruvate phosphate dikinase
QF06_15985	COG1309	transcriptional regulator
QF06_15990	COG2814	Major facilitator Superfamily
QF06_15995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QF06_16005	COG3409	Peptidoglycan-binding domain 1 protein
QF06_16005	COG0793	Belongs to the peptidase S41A family
QF06_16010	COG2177	Part of the ABC transporter FtsEX involved in
QF06_16015	COG2884	Cell division ATP-binding protein ftsE
QF06_16020	COG2010	Cytochrome c
QF06_16025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QF06_16030	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
QF06_16035	COG0653	protein targeting
QF06_16040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
QF06_16055	COG1516	flagellar protein fliS
QF06_16060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
QF06_16065	COG1334	flagellar protein FlaG
QF06_16070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
QF06_16075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
QF06_16080	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
QF06_16090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
QF06_16095	COG1256	bacterial-type flagellum assembly
QF06_16095	COG4786	Flagellar basal body rod
QF06_16100	COG3418	PFAM FlgN family protein
QF06_16105	COG2747	anti-sigma28 factor FlgM
QF06_16115	COG1040	competence protein
QF06_16125	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
QF06_16130	COG1307	EDD domain protein, DegV family
QF06_16135	COG2197	response regulator
QF06_16140	COG4585	Histidine kinase
QF06_16145	COG1739	Uncharacterized protein family UPF0029
QF06_16150	COG1316	TRANSCRIPTIONal
QF06_16155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
QF06_16160	COG0438	transferase activity, transferring glycosyl groups
QF06_16165	COG1215	transferase activity, transferring glycosyl groups
QF06_16170	COG3206	protein involved in exopolysaccharide biosynthesis
QF06_16175	COG3307	-O-antigen
QF06_16180	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
QF06_16185	COG0438	transferase activity, transferring glycosyl groups
QF06_16185	COG0297	glycogen (starch) synthase activity
QF06_16190	COG2244	polysaccharide biosynthetic process
QF06_16205	COG2247	cell wall binding repeat
QF06_16205	COG0860	N-Acetylmuramoyl-L-alanine amidase
QF06_16210	COG2385	sporulation resulting in formation of a cellular spore
QF06_16210	COG2247	cell wall binding repeat
QF06_16220	COG1316	TRANSCRIPTIONal
QF06_16225	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
QF06_16245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
QF06_16250	COG1134	teichoic acid transport
QF06_16255	COG1682	transport, permease protein
QF06_16260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
QF06_16260	COG1215	transferase activity, transferring glycosyl groups
QF06_16265	COG0463	Glycosyl transferase, family 2
QF06_16310	COG4193	domain, Protein
QF06_16315	COG1482	cell wall glycoprotein biosynthetic process
QF06_16320	COG0697	spore germination
QF06_16325	COG0814	amino acid
QF06_16335	COG2814	Major facilitator Superfamily
QF06_16340	COG1316	TRANSCRIPTIONal
QF06_16345	COG0561	phosphatase activity
QF06_16350	COG0791	NLP P60 protein
QF06_16355	COG2843	Capsule synthesis protein
QF06_16365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
QF06_16370	COG1609	Transcriptional regulator
QF06_16375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
QF06_16380	COG1869	D-ribose catabolic process
QF06_16385	COG1129	ABC transporter
QF06_16390	COG1172	Belongs to the binding-protein-dependent transport system permease family
QF06_16395	COG1879	ABC-type sugar transport system periplasmic component
QF06_16400	COG3103	Sh3 type 3 domain protein
QF06_16410	COG2249	NAD(P)H dehydrogenase (quinone) activity
QF06_16415	COG3527	Alpha-acetolactate decarboxylase
QF06_16420	COG0028	Belongs to the TPP enzyme family
QF06_16425	COG0583	DNA-binding transcription factor activity
QF06_16430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
QF06_16445	COG5337	Spore coat protein CotH
QF06_16455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
QF06_16465	COG0405	Gamma-glutamyltransferase
QF06_16470	COG1522	sequence-specific DNA binding
QF06_16475	COG2059	Chromate
QF06_16480	COG2059	Chromate
QF06_16495	COG5444	nuclease activity
QF06_16510	COG3878	Protein conserved in bacteria
QF06_16515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
QF06_16520	COG4464	protein tyrosine phosphatase activity
QF06_16525	COG0489	protein tyrosine kinase activity
QF06_16530	COG3944	biosynthesis protein
QF06_16535	COG4715	Zinc finger, swim domain protein
QF06_16540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
QF06_16545	COG0561	phosphatase activity
QF06_16550	COG1349	DNA-binding transcription factor activity
QF06_16555	COG0629	single-stranded DNA binding
QF06_16570	COG3764	Sortase (surface protein transpeptidase)
QF06_16580	COG3279	Response regulator of the LytR AlgR family
QF06_16585	COG2972	Histidine kinase
QF06_16585	COG0745	RESPONSE REGULATOR receiver
QF06_16590	COG1970	mechanosensitive ion channel activity
QF06_16595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
QF06_16600	COG0457	Tetratricopeptide repeat
QF06_16605	COG4786	Flagellar basal body rod
QF06_16610	COG4786	Flagellar basal body rod
QF06_16615	COG1077	Cell shape determining protein MreB Mrl
QF06_16620	COG1609	Transcriptional regulator
QF06_16625	COG1846	Transcriptional regulator
QF06_16630	COG2814	Major facilitator Superfamily
QF06_16635	COG3420	alginic acid biosynthetic process
QF06_16640	COG1953	Uracil, thiamine, allantoin
QF06_16645	COG0477	Major facilitator Superfamily
QF06_16650	COG1335	isochorismatase
QF06_16660	COG0004	ammonium transporteR
QF06_16665	COG0347	Belongs to the P(II) protein family
QF06_16670	COG0671	phosphoesterase, PA-phosphatase related
QF06_16680	COG0739	heme binding
QF06_16685	COG1247	-acetyltransferase
QF06_16700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
QF06_16705	COG0789	Transcriptional regulator
QF06_16715	COG2910	NAD(P)H-binding
QF06_16720	COG1959	2 iron, 2 sulfur cluster binding
QF06_16725	COG0804	urea catabolic process
QF06_16730	COG0832	Belongs to the urease beta subunit family
QF06_16735	COG0831	urea catabolic process
QF06_16745	COG3237	CsbD-like
QF06_16750	COG1994	Peptidase M50
QF06_16755	COG0457	Tetratricopeptide repeat
QF06_16760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
QF06_16765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
QF06_16770	COG2304	oxidoreductase activity
QF06_16780	COG2304	oxidoreductase activity
QF06_16785	COG2385	sporulation resulting in formation of a cellular spore
QF06_16790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
QF06_16800	COG4836	Membrane
QF06_16810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
QF06_16815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
QF06_16820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
QF06_16825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
QF06_16830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
QF06_16835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
QF06_16840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
QF06_16845	COG0356	it plays a direct role in the translocation of protons across the membrane
QF06_16855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
QF06_16860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
QF06_16865	COG4475	Protein of unknown function (DUF436)
QF06_16870	COG0698	ribose 5-phosphate isomerase
QF06_16875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
QF06_16880	COG1971	Probably functions as a manganese efflux pump
QF06_16885	COG0009	L-threonylcarbamoyladenylate synthase
QF06_16890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
QF06_16910	COG2890	protein-(glutamine-N5) methyltransferase activity
QF06_16915	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
QF06_16920	COG0346	lactoylglutathione lyase activity
QF06_16925	COG0789	Transcriptional regulator
QF06_16930	COG0679	Auxin Efflux Carrier
QF06_16935	COG0281	malic enzyme
QF06_16940	COG1435	thymidine kinase activity
QF06_16945	COG0254	rRNA binding
QF06_16950	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
QF06_16955	COG1494	fructose-1,6-bisphosphatase
QF06_16960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
QF06_16965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
QF06_16970	COG0191	fructose-bisphosphate aldolase activity
QF06_16975	COG2204	response regulator
QF06_16980	COG4821	SIS domain
QF06_16985	COG0504	CTP synthase activity
QF06_16990	COG3343	RNA polymerase activity
QF06_16995	COG1960	acyl-CoA dehydrogenase activity
QF06_17000	COG2181	nitrate reductase activity
QF06_17000	COG0247	lactate metabolic process
QF06_17005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
QF06_17010	COG4294	response to UV
QF06_17020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
QF06_17025	COG1132	(ABC) transporter
QF06_17030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
QF06_17035	COG2181	nitrate reductase activity
QF06_17040	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
QF06_17045	COG1140	nitrate reductase beta subunit
QF06_17050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
QF06_17055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
QF06_17065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
QF06_17070	COG2223	nitrite transmembrane transporter activity
QF06_17075	COG0018	arginyl-trna synthetase
QF06_17080	COG4506	Protein conserved in bacteria
QF06_17090	COG0535	radical SAM domain protein
QF06_17100	COG1131	(ABC) transporter
QF06_17105	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
QF06_17110	COG0612	Peptidase, M16
QF06_17115	COG0612	Peptidase, M16
QF06_17125	COG3391	amine dehydrogenase activity
QF06_17130	COG3391	amine dehydrogenase activity
QF06_17140	COG0457	Tetratricopeptide repeat
QF06_17170	COG1131	(ABC) transporter
QF06_17180	COG0010	Belongs to the arginase family
QF06_17185	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
QF06_17190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
QF06_17205	COG1994	Peptidase M50
QF06_17210	COG1942	4-Oxalocrotonate Tautomerase
QF06_17215	COG1846	Transcriptional regulator
QF06_17220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
QF06_17225	COG0477	Major facilitator Superfamily
QF06_17230	COG1959	2 iron, 2 sulfur cluster binding
QF06_17235	COG3465	dGTPase activity
QF06_17240	COG1078	dGTPase activity
QF06_17245	COG4844	belongs to the
QF06_17255	COG0697	spore germination
QF06_17260	COG0095	Lipoate-protein ligase
QF06_17265	COG0583	DNA-binding transcription factor activity
QF06_17270	COG0280	phosphate acetyltransferase
QF06_17280	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_17285	COG0436	Aminotransferase
QF06_17290	COG2814	Major facilitator Superfamily
QF06_17295	COG0151	Belongs to the GarS family
QF06_17300	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_17305	COG1917	Cupin 2, conserved barrel domain protein
QF06_17310	COG0077	Prephenate dehydratase
QF06_17315	COG2814	Major facilitator Superfamily
QF06_17320	COG0833	amino acid
QF06_17325	COG4187	Peptidase family M20/M25/M40
QF06_17330	COG1012	belongs to the aldehyde dehydrogenase family
QF06_17335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
QF06_17345	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
QF06_17350	COG1091	dTDP-4-dehydrorhamnose reductase activity
QF06_17355	COG1088	dTDP-glucose 4,6-dehydratase activity
QF06_17360	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
QF06_17365	COG3980	spore coat polysaccharide biosynthesis protein
QF06_17370	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
QF06_17375	COG2089	acid synthase
QF06_17380	COG0456	acetyltransferase
QF06_17385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
QF06_17390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
QF06_17395	COG0463	Glycosyl transferase, family 2
QF06_17405	COG2363	Small membrane protein
QF06_17410	COG2233	PERMEase
QF06_17420	COG1012	belongs to the aldehyde dehydrogenase family
QF06_17425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
QF06_17430	COG1216	Glycosyl transferase, family 2
QF06_17445	COG1695	Transcriptional regulator
QF06_17450	COG0351	phosphomethylpyrimidine kinase
QF06_17460	COG1621	beta-fructofuranosidase activity
QF06_17465	COG1263	PTS System
QF06_17465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_17470	COG2116	formate transmembrane transporter activity
QF06_17475	COG3711	transcriptional antiterminator
QF06_17485	COG1404	Belongs to the peptidase S8 family
QF06_17490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
QF06_17495	COG0778	Nitroreductase
QF06_17500	COG0772	Belongs to the SEDS family
QF06_17510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
QF06_17515	COG1845	cytochrome c oxidase, subunit III
QF06_17520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
QF06_17525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
QF06_17530	COG2261	transglycosylase associated protein
QF06_17535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
QF06_17540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
QF06_17545	COG2246	polysaccharide biosynthetic process
QF06_17550	COG1309	transcriptional regulator
QF06_17560	COG3162	membrane
QF06_17565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
QF06_17570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
QF06_17575	COG2837	iron assimilation
QF06_17580	COG2822	iron ion transport
QF06_17585	COG0672	)-iron permease
QF06_17590	COG0352	thiamine-phosphate diphosphorylase activity
QF06_17595	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
QF06_17600	COG0583	DNA-binding transcription factor activity
QF06_17605	COG1380	Effector of murein hydrolase LrgA
QF06_17610	COG1346	cytolysis
QF06_17615	COG2814	Major facilitator Superfamily
QF06_17620	COG4895	conserved protein (DUF2196)
QF06_17625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
QF06_17630	COG0346	lactoylglutathione lyase activity
QF06_17645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QF06_17650	COG1404	Belongs to the peptidase S8 family
QF06_17655	COG1263	PTS System
QF06_17655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_17660	COG3711	transcriptional antiterminator
QF06_17665	COG1442	glycosyl transferase family 8
QF06_17670	COG5522	Integral membrane protein (intg_mem_TP0381)
QF06_17675	COG1846	Transcriptional regulator
QF06_17680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
QF06_17685	COG2234	aminopeptidase activity
QF06_17700	COG2814	Major facilitator Superfamily
QF06_17705	COG2357	RelA SpoT domain protein
QF06_17710	COG1575	Belongs to the MenA family. Type 1 subfamily
QF06_17720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
QF06_17725	COG1696	Membrane protein involved in D-alanine export
QF06_17730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
QF06_17735	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
QF06_17740	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
QF06_17745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QF06_17750	COG1486	melibiose metabolic process
QF06_17755	COG1447	Phosphotransferase system cellobiose-specific component IIA
QF06_17760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QF06_17765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
QF06_17770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
QF06_17770	COG3711	transcriptional antiterminator
QF06_17775	COG2094	Belongs to the DNA glycosylase MPG family
QF06_17780	COG0753	catalase activity
QF06_17785	COG2814	Major facilitator Superfamily
QF06_17790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
QF06_17795	COG1131	(ABC) transporter
QF06_17815	COG1595	DNA-templated transcription, initiation
QF06_17820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
QF06_17825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
QF06_17830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
QF06_17835	COG4988	ABC transporter
QF06_17840	COG1294	oxidase, subunit
QF06_17845	COG1271	oxidase subunit
QF06_17850	COG3493	citrate carrier protein
QF06_17855	COG0501	Belongs to the peptidase M48B family
QF06_17865	COG0726	polysaccharide deacetylase
QF06_17880	COG3842	ATPase activity
QF06_17885	COG2508	Transcriptional regulator
QF06_17890	COG1012	belongs to the aldehyde dehydrogenase family
QF06_17895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
QF06_17905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
QF06_17910	COG1881	PFAM PEBP family protein
QF06_17915	COG0583	DNA-binding transcription factor activity
QF06_17925	COG4585	Histidine kinase
QF06_17930	COG2197	response regulator
QF06_17935	COG2195	Cleaves the N-terminal amino acid of tripeptides
QF06_17940	COG4894	glucomannan catabolic process
QF06_17945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
QF06_17950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
QF06_17955	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_17960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
QF06_17965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
QF06_17970	COG2610	gluconate transmembrane transporter activity
QF06_17975	COG0500	methyltransferase
QF06_17980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
QF06_17995	COG0693	protein deglycase activity
QF06_17995	COG0753	catalase activity
QF06_18000	COG2851	Citrate transporter
QF06_18005	COG2273	Hydrolase Family 16
QF06_18010	COG3711	transcriptional antiterminator
QF06_18020	COG2270	Major facilitator Superfamily
QF06_18025	COG0513	Belongs to the DEAD box helicase family
QF06_18030	COG2755	lipolytic protein G-D-S-L family
QF06_18030	COG3401	FG-GAP repeat protein
QF06_18070	COG3209	COG3209 Rhs family protein
QF06_18075	COG0697	spore germination
QF06_18080	COG0589	response to stress
QF06_18085	COG2723	6-phospho-beta-galactosidase activity
QF06_18090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_18090	COG2190	(PTS) system
QF06_18090	COG1263	PTS System
QF06_18135	COG3507	Belongs to the glycosyl hydrolase 43 family
QF06_18145	COG2986	histidine ammonia-lyase
QF06_18150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
QF06_18155	COG1228	amidohydrolase
QF06_18160	COG0010	Belongs to the arginase family
QF06_18165	COG0833	amino acid
QF06_18170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
QF06_18175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
QF06_18180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
QF06_18185	COG2390	Transcriptional regulator
QF06_18195	COG3192	ethanolamine utilization protein
QF06_18200	COG2079	MmgE PrpD family protein
QF06_18210	COG1126	abc transporter atp-binding protein
QF06_18215	COG0765	amino acid transport
QF06_18220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
QF06_18235	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
QF06_18240	COG0561	phosphatase activity
QF06_18270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QF06_18275	COG5294	Protein conserved in bacteria
QF06_18280	COG0577	efflux transmembrane transporter activity
QF06_18285	COG1136	(ABC) transporter
QF06_18290	COG2205	protein histidine kinase activity
QF06_18295	COG0745	RESPONSE REGULATOR receiver
QF06_18300	COG0191	fructose-bisphosphate aldolase activity
QF06_18305	COG1082	Xylose isomerase domain protein TIM barrel
QF06_18310	COG1082	Xylose isomerase domain protein TIM barrel
QF06_18315	COG0673	inositol 2-dehydrogenase activity
QF06_18320	COG2814	Major facilitator Superfamily
QF06_18325	COG1082	Xylose isomerase domain protein TIM barrel
QF06_18330	COG3962	Belongs to the TPP enzyme family
QF06_18335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
QF06_18345	COG1012	belongs to the aldehyde dehydrogenase family
QF06_18350	COG1349	DNA-binding transcription factor activity
QF06_18355	COG0667	Aldo Keto reductase
QF06_18370	COG2814	Major facilitator Superfamily
QF06_18375	COG0326	Molecular chaperone. Has ATPase activity
QF06_18385	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_18410	COG1309	transcriptional regulator
QF06_18415	COG1012	belongs to the aldehyde dehydrogenase family
QF06_18420	COG1714	RDD family
QF06_18425	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
QF06_18435	COG1714	RDD family
QF06_18440	COG2311	Membrane
QF06_18445	COG1917	Cupin 2, conserved barrel domain protein
QF06_18450	COG1309	transcriptional regulator
QF06_18455	COG1028	Short-chain dehydrogenase reductase Sdr
QF06_18460	COG1846	Transcriptional regulator
QF06_18465	COG1380	Effector of murein hydrolase LrgA
QF06_18470	COG1346	cytolysis
QF06_18475	COG5039	Polysaccharide pyruvyl transferase
QF06_18480	COG1929	Belongs to the glycerate kinase type-1 family
QF06_18485	COG1802	Transcriptional regulator
QF06_18490	COG1070	Carbohydrate kinase
QF06_18495	COG2610	gluconate transmembrane transporter activity
QF06_18500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
QF06_18505	COG0450	alkyl hydroperoxide reductase
QF06_18510	COG3634	alkyl hydroperoxide reductase activity
QF06_18530	COG2188	Transcriptional regulator
QF06_18545	COG1131	(ABC) transporter
QF06_18550	COG1994	Peptidase M50
QF06_18555	COG0535	radical SAM domain protein
QF06_18565	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
QF06_18575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
QF06_18585	COG1063	alcohol dehydrogenase
QF06_18605	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
QF06_18610	COG0456	acetyltransferase
QF06_18615	COG0457	Tetratricopeptide repeat
QF06_18625	COG0010	Belongs to the arginase family
QF06_18630	COG0833	amino acid
QF06_18635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
QF06_18640	COG3829	transcription factor binding
QF06_18645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
QF06_18650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
QF06_18655	COG4853	Protein conserved in bacteria
QF06_18660	COG4863	YycH protein
QF06_18665	COG5002	protein histidine kinase activity
QF06_18670	COG0745	RESPONSE REGULATOR receiver
QF06_18700	COG0346	lactoylglutathione lyase activity
QF06_18705	COG0305	Participates in initiation and elongation during chromosome replication
QF06_18720	COG2807	transmembrane transport
QF06_18725	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
QF06_18730	COG0359	binds to the 23S rRNA
QF06_18735	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
QF06_18740	COG4241	membrane
QF06_18750	COG5577	PFAM Coat F domain
QF06_18755	COG1733	regulation of RNA biosynthetic process
QF06_18760	COG1227	inorganic diphosphatase activity
QF06_18775	COG2271	Major facilitator Superfamily
QF06_18780	COG0789	Transcriptional regulator
QF06_18780	COG4978	Transcriptional regulator
QF06_18795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
QF06_18800	COG1846	Transcriptional regulator
QF06_18805	COG2153	protein acetylation
QF06_18810	COG2364	Membrane
QF06_18815	COG0456	acetyltransferase
QF06_18820	COG2315	Protein conserved in bacteria
QF06_18825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
QF06_18835	COG0789	Transcriptional regulator
QF06_18840	COG0697	spore germination
QF06_18845	COG1331	Highly conserved protein containing a thioredoxin domain
QF06_18850	COG1266	CAAX protease self-immunity
QF06_18855	COG0477	Major facilitator Superfamily
QF06_18855	COG2814	Major facilitator Superfamily
QF06_18860	COG0110	maltose O-acetyltransferase activity
QF06_18865	COG0346	lactoylglutathione lyase activity
QF06_18870	COG1609	Transcriptional regulator
QF06_18875	COG0708	Exodeoxyribonuclease III
QF06_18880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
QF06_18885	COG0629	single-stranded DNA binding
QF06_18890	COG0360	Binds together with S18 to 16S ribosomal RNA
QF06_18895	COG0012	GTP binding
QF06_18900	COG0243	molybdopterin cofactor binding
QF06_18905	COG4481	Protein conserved in bacteria
QF06_18910	COG3949	Membrane
QF06_18920	COG1475	DNA binding
QF06_18925	COG1192	Involved in chromosome partitioning
QF06_18935	COG1475	DNA binding
QF06_18940	COG0357	Ribosomal RNA small subunit methyltransferase G
QF06_18945	COG0445	tRNA wobble uridine modification
QF06_18950	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
QF06_18955	COG1847	R3H domain protein
QF06_18960	COG0706	membrane insertase activity
QF06_18965	COG0594	ribonuclease P activity
QF06_18970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
QF06_18975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
QF06_18980	COG0592	DNA-directed DNA polymerase activity
QF06_18985	COG2501	S4 domain
QF06_18990	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
QF06_19000	COG0187	DNA topoisomerase II activity
QF06_19005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
QF06_19030	COG0516	GMP reductase activity
QF06_19030	COG0517	IMP dehydrogenase activity
QF06_19035	COG1686	Belongs to the peptidase S11 family
QF06_19040	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
QF06_19045	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
QF06_19050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
QF06_19060	COG1428	Deoxynucleoside kinase
QF06_19065	COG1428	Deoxynucleoside kinase
QF06_19070	COG1388	LysM domain
QF06_19070	COG3858	chitin binding
QF06_19075	COG1335	isochorismatase
QF06_19080	COG0590	tRNA wobble adenosine to inosine editing
QF06_19085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
QF06_19090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
QF06_19095	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
QF06_19130	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
QF06_19135	COG3853	Toxic anion resistance protein (TelA)
QF06_19140	COG1982	Orn Lys Arg decarboxylase major
QF06_19145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
QF06_19150	COG3870	Protein conserved in bacteria
QF06_19155	COG1728	Protein conserved in bacteria
QF06_19160	COG0470	DNA polymerase III
QF06_19165	COG1774	PSP1 C-terminal conserved region
QF06_19170	COG4467	Involved in initiation control of chromosome replication
QF06_19175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
QF06_19180	COG2827	Endonuclease containing a URI domain
QF06_19185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
QF06_19190	COG2002	toxin-antitoxin pair type II binding
QF06_19195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QF06_19195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
QF06_19200	COG0084	hydrolase, TatD family'
QF06_19205	COG3584	3D domain protein
QF06_19205	COG3583	domain protein
QF06_19210	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
QF06_19215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
QF06_19225	COG4466	Protein conserved in bacteria
QF06_19235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
QF06_19240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
QF06_19245	COG0251	oxidation-reduction process
QF06_19250	COG2088	sporulation resulting in formation of a cellular spore
QF06_19255	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
QF06_19260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
QF06_19265	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
QF06_19270	COG0193	aminoacyl-tRNA hydrolase activity
QF06_19280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
QF06_19285	COG2002	toxin-antitoxin pair type II binding
QF06_19290	COG2244	polysaccharide biosynthetic process
QF06_19295	COG3956	TIGRFAM MazG family protein
QF06_19300	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
QF06_19315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
QF06_19320	COG1098	S1 RNA binding domain
QF06_19335	COG2208	phosphoserine phosphatase activity
QF06_19340	COG2304	oxidoreductase activity
QF06_19345	COG0515	serine threonine protein kinase
QF06_19350	COG0037	tRNA processing
QF06_19360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
QF06_19365	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
QF06_19370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
QF06_19375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
QF06_19380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
QF06_19385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
QF06_19390	COG0512	Glutamine amidotransferase of anthranilate synthase
QF06_19395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
QF06_19400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
QF06_19405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
QF06_19410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
QF06_19415	COG1396	sequence-specific DNA binding
QF06_19420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
QF06_19425	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
QF06_19490	COG4463	regulation of RNA biosynthetic process
QF06_19495	COG3880	PFAM UvrB UvrC protein
QF06_19500	COG3869	Catalyzes the specific phosphorylation of arginine residues in
QF06_19505	COG0542	response to heat
QF06_19510	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
QF06_19515	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
QF06_19520	COG4956	integral membrane protein (PIN domain superfamily)
QF06_19525	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
QF06_19530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
QF06_19535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
QF06_19545	COG1045	serine acetyltransferase
QF06_19550	COG0215	cysteine-tRNA ligase activity
QF06_19555	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
QF06_19560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
QF06_19565	COG3688	RNA-binding protein containing a PIN domain
QF06_19570	COG1595	DNA-templated transcription, initiation
QF06_19575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
QF06_19580	COG0250	Participates in transcription elongation, termination and antitermination
QF06_19585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
QF06_19590	COG0081	regulation of translation
QF06_19595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
QF06_19600	COG0222	ribosome binding
QF06_19605	COG2813	Specifically methylates the guanine in position
QF06_19610	COG0085	RNA polymerase activity
QF06_19615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
QF06_19620	COG1358	cellular component organization or biogenesis
QF06_19625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
QF06_19630	COG0049	tRNA binding
QF06_19635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
QF06_19640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
QF06_19645	COG0596	Alpha beta hydrolase
QF06_19650	COG0051	transcription antitermination factor activity, RNA binding
QF06_19655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
QF06_19660	COG0088	Forms part of the polypeptide exit tunnel
QF06_19665	COG0089	rRNA binding
QF06_19670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
QF06_19675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
QF06_19680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
QF06_19685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
QF06_19690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
QF06_19695	COG0255	Belongs to the universal ribosomal protein uL29 family
QF06_19700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
QF06_19705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
QF06_19715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
QF06_19725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
QF06_19730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
QF06_19735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
QF06_19740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
QF06_19745	COG1841	ribosomal large subunit assembly
QF06_19750	COG0200	Binds to the 23S rRNA
QF06_19755	COG0201	protein transport
QF06_19760	COG0563	adenylate kinase activity
QF06_19765	COG0024	Methionine aminopeptidase
QF06_19770	COG2163	COG2163 Ribosomal protein L14E L6E L27E
QF06_19775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
QF06_19780	COG0257	Belongs to the bacterial ribosomal protein bL36 family
QF06_19785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
QF06_19790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
QF06_19795	COG0202	RNA polymerase activity
QF06_19800	COG0203	ribosomal protein L17
QF06_19805	COG1122	ATPase activity
QF06_19810	COG1122	ATPase activity
QF06_19815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
QF06_19820	COG0101	tRNA pseudouridine synthase activity
QF06_19825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
QF06_19830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
QF06_19835	COG2226	methyltransferase
QF06_19845	COG0860	N-Acetylmuramoyl-L-alanine amidase
QF06_19850	COG0489	protein tyrosine kinase activity
QF06_19860	COG2194	sulfuric ester hydrolase activity
QF06_19865	COG0726	polysaccharide deacetylase
QF06_19975	COG0659	secondary active sulfate transmembrane transporter activity
QF06_19980	COG0385	Bile acid
QF06_19985	COG2819	hydrolase of the alpha beta superfamily
QF06_19990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_19995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
QF06_20000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QF06_20005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
QF06_20005	COG2207	Transcriptional regulator
QF06_20010	COG3876	Protein conserved in bacteria
QF06_20015	COG1472	Belongs to the glycosyl hydrolase 3 family
QF06_20020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
QF06_20025	COG1263	PTS System
QF06_20025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
QF06_20030	COG1737	Transcriptional regulator
QF06_20035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
QF06_20040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
QF06_20045	COG1683	Conserved Protein
QF06_20075	COG1595	DNA-templated transcription, initiation
QF06_20080	COG5662	AntiSigma factor
QF06_20085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
QF06_20090	COG4856	YbbR-like protein
QF06_20095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
QF06_20100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
QF06_20105	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
QF06_20110	COG2169	Transcriptional regulator
QF06_20115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
QF06_20120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
QF06_20125	COG3002	Belongs to the UPF0753 family
QF06_20130	COG0288	reversible hydration of carbon dioxide
QF06_20140	COG5609	conserved protein (DUF2294)
QF06_20145	COG0640	Transcriptional regulator
QF06_20150	COG2814	Major facilitator Superfamily
QF06_20165	COG0515	serine threonine protein kinase
QF06_20180	COG1113	amino acid transport
QF06_20195	COG2602	Beta-lactamase
QF06_20250	COG5444	nuclease activity
QF06_20400	COG0457	Tetratricopeptide repeat
QF06_20430	COG0582	viral genome integration into host DNA
QF06_20500	COG2887	Belongs to the helicase family. UvrD subfamily
QF06_20505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
QF06_20510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
QF06_20515	COG0716	FMN binding
QF06_20555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
QF06_20590	COG0328	RNA-DNA hybrid ribonuclease activity
QF06_20610	COG0587	DNA-directed DNA polymerase activity
QF06_20630	COG0194	GDP metabolic process
QF06_20675	COG0187	DNA topoisomerase II activity