locus-tag	class	description
ZHX2020_00005	COG1086	Polysaccharide biosynthesis protein
ZHX2020_00010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZHX2020_00015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZHX2020_00020	COG1846	Transcriptional regulator
ZHX2020_00025	COG0534	Mate efflux family protein
ZHX2020_00035	COG4698	Protein conserved in bacteria
ZHX2020_00040	COG2755	lipolytic protein G-D-S-L family
ZHX2020_00045	COG1999	signal sequence binding
ZHX2020_00055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZHX2020_00060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ZHX2020_00065	COG1272	protein, Hemolysin III
ZHX2020_00070	COG0204	Acyl-transferase
ZHX2020_00075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZHX2020_00080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ZHX2020_00090	COG2136	Putative SAM-dependent methyltransferase
ZHX2020_00090	COG2521	methyltransferase
ZHX2020_00100	COG0129	dihydroxy-acid dehydratase activity
ZHX2020_00105	COG1413	lyase activity
ZHX2020_00110	COG1418	mRNA catabolic process
ZHX2020_00115	COG0386	Belongs to the glutathione peroxidase family
ZHX2020_00120	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ZHX2020_00125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZHX2020_00135	COG1278	Cold shock
ZHX2020_00155	COG0328	RNA-DNA hybrid ribonuclease activity
ZHX2020_00160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ZHX2020_00165	COG0328	RNA-DNA hybrid ribonuclease activity
ZHX2020_00175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZHX2020_00190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ZHX2020_00200	COG1755	Isoprenylcysteine carboxyl methyltransferase
ZHX2020_00205	COG3424	synthase
ZHX2020_00210	COG2233	PERMEase
ZHX2020_00215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ZHX2020_00220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ZHX2020_00230	COG0800	Aldolase
ZHX2020_00235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZHX2020_00240	COG1609	Transcriptional regulator
ZHX2020_00245	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ZHX2020_00250	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_00255	COG1199	ATP-dependent helicase activity
ZHX2020_00270	COG0116	Belongs to the methyltransferase superfamily
ZHX2020_00285	COG4474	Belongs to the UPF0398 family
ZHX2020_00300	COG3359	exonuclease
ZHX2020_00305	COG1111	helicase
ZHX2020_00305	COG1205	dead DEAH box helicase
ZHX2020_00310	COG2190	(PTS) system
ZHX2020_00315	COG0071	Belongs to the small heat shock protein (HSP20) family
ZHX2020_00350	COG3331	DNA recombination
ZHX2020_00355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZHX2020_00355	COG4499	WXG100 protein secretion system (Wss), protein YukC
ZHX2020_00365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ZHX2020_00370	COG3935	DnaD domain protein
ZHX2020_00375	COG0017	Asparaginyl-tRNA synthetase
ZHX2020_00380	COG0436	Aminotransferase
ZHX2020_00385	COG5353	protein conserved in bacteria
ZHX2020_00395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZHX2020_00395	COG1199	ATP-dependent helicase activity
ZHX2020_00400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ZHX2020_00405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ZHX2020_00410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ZHX2020_00415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ZHX2020_00415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ZHX2020_00420	COG0617	tRNA 3'-terminal CCA addition
ZHX2020_00425	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_00430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ZHX2020_00435	COG1803	Methylglyoxal synthase
ZHX2020_00440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZHX2020_00445	COG1694	Mazg nucleotide pyrophosphohydrolase
ZHX2020_00450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZHX2020_00460	COG4347	Protein of unknown function (DUF1405)
ZHX2020_00465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZHX2020_00465	COG2010	Cytochrome c
ZHX2020_00470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZHX2020_00475	COG0723	plastoquinol--plastocyanin reductase activity
ZHX2020_00485	COG5582	Belongs to the UPF0302 family
ZHX2020_00490	COG0457	Tetratricopeptide repeat
ZHX2020_00495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZHX2020_00500	COG0287	Prephenate dehydrogenase
ZHX2020_00515	COG0133	tryptophan synthase activity
ZHX2020_00520	COG0135	phosphoribosylanthranilate isomerase activity
ZHX2020_00530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZHX2020_00535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZHX2020_00540	COG4401	Chorismate mutase type I
ZHX2020_00545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZHX2020_00550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZHX2020_00555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ZHX2020_00560	COG0105	UTP biosynthetic process
ZHX2020_00565	COG0142	geranyltranstransferase activity
ZHX2020_00570	COG2226	methyltransferase
ZHX2020_00575	COG0142	geranyltranstransferase activity
ZHX2020_00585	COG0302	gtp cyclohydrolase
ZHX2020_00590	COG0776	regulation of translation
ZHX2020_00595	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ZHX2020_00610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZHX2020_00615	COG1160	GTP binding
ZHX2020_00640	COG1304	FMN binding
ZHX2020_00645	COG0539	negative regulation of cytoplasmic translation
ZHX2020_00650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZHX2020_00660	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ZHX2020_00665	COG2959	enzyme of heme biosynthesis
ZHX2020_00670	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_00670	COG3773	Cell wall hydrolase
ZHX2020_00675	COG2339	peptidase activity
ZHX2020_00680	COG0492	ferredoxin-NADP+ reductase activity
ZHX2020_00685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZHX2020_00690	COG4862	establishment of competence for transformation
ZHX2020_00695	COG1408	metallophosphoesterase
ZHX2020_00705	COG1388	LysM domain
ZHX2020_00710	COG1266	CAAX protease self-immunity
ZHX2020_00715	COG0514	ATP-dependent DNA helicase (RecQ)
ZHX2020_00720	COG4955	Helix-turn-helix domain
ZHX2020_00725	COG1141	Ferredoxin
ZHX2020_00730	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ZHX2020_00735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZHX2020_00740	COG0710	3-dehydroquinate dehydratase activity
ZHX2020_00750	COG1595	DNA-templated transcription, initiation
ZHX2020_00755	COG5002	protein histidine kinase activity
ZHX2020_00760	COG0745	RESPONSE REGULATOR receiver
ZHX2020_00765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZHX2020_00770	COG1333	cytochrome c biogenesis protein
ZHX2020_00775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_00780	COG1187	pseudouridine synthase activity
ZHX2020_00785	COG0700	Nucleoside recognition
ZHX2020_00790	COG2715	membrane protein required for spore maturation
ZHX2020_00795	COG1686	Belongs to the peptidase S11 family
ZHX2020_00805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ZHX2020_00810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ZHX2020_00815	COG1547	Domain of unknown function (DUF309)
ZHX2020_00820	COG0456	acetyltransferase
ZHX2020_00825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZHX2020_00830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZHX2020_00830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZHX2020_00835	COG0307	riboflavin synthase, alpha
ZHX2020_00840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZHX2020_00840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZHX2020_00850	COG0681	Belongs to the peptidase S26 family
ZHX2020_00860	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ZHX2020_00910	COG3328	transposase activity
ZHX2020_00960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZHX2020_00970	COG4086	secreted protein
ZHX2020_00975	COG0019	diaminopimelate decarboxylase activity
ZHX2020_00980	COG0697	spore germination
ZHX2020_00995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZHX2020_01015	COG1191	sigma factor activity
ZHX2020_01020	COG2172	sigma factor antagonist activity
ZHX2020_01025	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_01030	COG1686	Belongs to the peptidase S11 family
ZHX2020_01035	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ZHX2020_01040	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ZHX2020_01045	COG4974	Belongs to the 'phage' integrase family
ZHX2020_01055	COG0735	belongs to the Fur family
ZHX2020_01060	COG1300	Membrane
ZHX2020_01070	COG0281	malic enzyme
ZHX2020_01075	COG1757	Na H antiporter
ZHX2020_01080	COG1027	Aspartate ammonia-lyase
ZHX2020_01085	COG0252	asparaginase activity
ZHX2020_01090	COG1396	sequence-specific DNA binding
ZHX2020_01095	COG1379	DNA repair
ZHX2020_01100	COG0494	nUDIX hydrolase
ZHX2020_01110	COG0667	Aldo Keto reductase
ZHX2020_01120	COG1073	alpha beta
ZHX2020_01130	COG4918	Iron-sulphur cluster biosynthesis
ZHX2020_01135	COG0456	acetyltransferase
ZHX2020_01135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ZHX2020_01140	COG2329	Antibiotic biosynthesis monooxygenase
ZHX2020_01145	COG0456	acetyltransferase
ZHX2020_01155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZHX2020_01165	COG2211	Major facilitator Superfamily
ZHX2020_01175	COG0346	lactoylglutathione lyase activity
ZHX2020_01180	COG1072	(Pantothenic acid kinase))
ZHX2020_01185	COG3048	D-serine ammonia-lyase activity
ZHX2020_01190	COG0300	oxidoreductase activity
ZHX2020_01195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZHX2020_01200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZHX2020_01205	COG4187	Peptidase family M20/M25/M40
ZHX2020_01210	COG1902	pentaerythritol trinitrate reductase activity
ZHX2020_01220	COG0596	Alpha beta hydrolase
ZHX2020_01230	COG1234	tRNA 3'-trailer cleavage
ZHX2020_01235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZHX2020_01240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ZHX2020_01245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZHX2020_01255	COG0706	membrane insertase activity
ZHX2020_01260	COG3361	conserved protein (COG2071)
ZHX2020_01265	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZHX2020_01275	COG0346	lactoylglutathione lyase activity
ZHX2020_01285	COG1376	ErfK ybiS ycfS ynhG family protein
ZHX2020_01290	COG4129	membrane
ZHX2020_01295	COG1126	abc transporter atp-binding protein
ZHX2020_01300	COG0765	amino acid transport
ZHX2020_01305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZHX2020_01315	COG1597	lipid kinase activity
ZHX2020_01325	COG0789	Transcriptional regulator
ZHX2020_01325	COG4978	Transcriptional regulator
ZHX2020_01330	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZHX2020_01335	COG0022	dehydrogenase e1 component
ZHX2020_01340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZHX2020_01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZHX2020_01350	COG3426	butyrate kinase activity
ZHX2020_01355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZHX2020_01360	COG0280	phosphate acetyltransferase
ZHX2020_01365	COG3290	protein histidine kinase activity
ZHX2020_01365	COG3829	transcription factor binding
ZHX2020_01375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ZHX2020_01380	COG2079	MmgE PrpD family protein
ZHX2020_01385	COG0372	Belongs to the citrate synthase family
ZHX2020_01390	COG1960	acyl-CoA dehydrogenase activity
ZHX2020_01395	COG1250	3-hydroxyacyl-CoA dehydrogenase
ZHX2020_01400	COG0183	Belongs to the thiolase family
ZHX2020_01405	COG0584	glycerophosphoryl diester phosphodiesterase
ZHX2020_01410	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_01425	COG1902	pentaerythritol trinitrate reductase activity
ZHX2020_01430	COG0745	RESPONSE REGULATOR receiver
ZHX2020_01435	COG0750	zinc metalloprotease
ZHX2020_01440	COG0497	DNA recombination
ZHX2020_01445	COG1438	arginine binding
ZHX2020_01450	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZHX2020_01455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZHX2020_01460	COG0142	geranyltranstransferase activity
ZHX2020_01465	COG1722	exodeoxyribonuclease VII activity
ZHX2020_01470	COG1570	exodeoxyribonuclease VII activity
ZHX2020_01475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZHX2020_01480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZHX2020_01485	COG1302	Protein conserved in bacteria
ZHX2020_01490	COG0439	Biotin carboxylase
ZHX2020_01495	COG0511	ligase activity, forming carbon-carbon bonds
ZHX2020_01540	COG3854	ATPases associated with a variety of cellular activities
ZHX2020_01550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZHX2020_01555	COG0006	proline dipeptidase activity
ZHX2020_01560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZHX2020_01570	COG3872	metal-dependent enzyme
ZHX2020_01580	COG1752	Esterase of the alpha-beta hydrolase superfamily
ZHX2020_01585	COG1321	iron dependent repressor
ZHX2020_01590	COG0095	Lipoate-protein ligase
ZHX2020_01595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZHX2020_01600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ZHX2020_01605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ZHX2020_01610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ZHX2020_01615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ZHX2020_01630	COG1396	sequence-specific DNA binding
ZHX2020_01640	COG0681	Belongs to the peptidase S26 family
ZHX2020_01665	COG4940	Competence protein ComGF
ZHX2020_01675	COG4970	Tfp pilus assembly protein FimT
ZHX2020_01680	COG4537	Required for transformation and DNA binding
ZHX2020_01685	COG1459	type II secretion system
ZHX2020_01690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ZHX2020_01695	COG0517	IMP dehydrogenase activity
ZHX2020_01700	COG0598	Magnesium transport protein CorA
ZHX2020_01705	COG1253	flavin adenine dinucleotide binding
ZHX2020_01710	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_01720	COG1393	Belongs to the ArsC family
ZHX2020_01730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZHX2020_01740	COG0011	TIGRFAM Protein of
ZHX2020_01750	COG2866	Carboxypeptidase
ZHX2020_01755	COG1368	sulfuric ester hydrolase activity
ZHX2020_01760	COG1940	carbohydrate kinase activity
ZHX2020_01765	COG4483	Protein conserved in bacteria
ZHX2020_01770	COG0705	Rhomboid family
ZHX2020_01770	COG0457	Tetratricopeptide repeat
ZHX2020_01780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ZHX2020_01790	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_01805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZHX2020_01810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZHX2020_01815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZHX2020_01820	COG0581	inorganic phosphate transmembrane transporter activity
ZHX2020_01825	COG0573	inorganic phosphate transmembrane transporter activity
ZHX2020_01830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ZHX2020_01835	COG0768	penicillin binding
ZHX2020_01840	COG0477	Major facilitator Superfamily
ZHX2020_01845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZHX2020_01850	COG2839	Protein conserved in bacteria
ZHX2020_01855	COG5521	maltodextrose utilization protein MalA
ZHX2020_01860	COG1388	LysM domain
ZHX2020_01865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ZHX2020_01870	COG4709	membrane
ZHX2020_01875	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ZHX2020_01880	COG0735	belongs to the Fur family
ZHX2020_01885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZHX2020_01895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ZHX2020_01900	COG0513	Belongs to the DEAD box helicase family
ZHX2020_01910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ZHX2020_01915	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ZHX2020_01920	COG2384	SAM-dependent methyltransferase
ZHX2020_01925	COG2010	Cytochrome c
ZHX2020_01930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZHX2020_01935	COG0358	DNA primase activity
ZHX2020_01940	COG1671	Belongs to the UPF0178 family
ZHX2020_01945	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ZHX2020_01950	COG0517	IMP dehydrogenase activity
ZHX2020_01955	COG0751	glycine-tRNA ligase activity
ZHX2020_01960	COG0752	glycyl-tRNA synthetase alpha subunit
ZHX2020_01965	COG1381	Involved in DNA repair and RecF pathway recombination
ZHX2020_01975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZHX2020_01980	COG0295	cytidine deaminase activity
ZHX2020_01985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ZHX2020_01990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZHX2020_01995	COG1480	7TM receptor with intracellular HD hydrolase
ZHX2020_02000	COG1702	phosphate starvation-inducible protein PhoH
ZHX2020_02005	COG0561	phosphatase activity
ZHX2020_02020	COG4864	UPF0365 protein
ZHX2020_02025	COG1030	water channel activity
ZHX2020_02030	COG1610	YqeY-like protein
ZHX2020_02040	COG1283	sodium-dependent phosphate transmembrane transporter activity
ZHX2020_02045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZHX2020_02050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ZHX2020_02055	COG2264	protein methyltransferase activity
ZHX2020_02060	COG0484	heat shock protein binding
ZHX2020_02065	COG0443	Heat shock 70 kDa protein
ZHX2020_02070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZHX2020_02075	COG1420	regulation of RNA biosynthetic process
ZHX2020_02080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZHX2020_02085	COG0481	GTPase activity
ZHX2020_02095	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_02100	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ZHX2020_02105	COG0268	Binds directly to 16S ribosomal RNA
ZHX2020_02110	COG1466	dna polymerase III delta subunit
ZHX2020_02125	COG2333	competence protein COMEC
ZHX2020_02125	COG0658	competence protein
ZHX2020_02130	COG2131	deaminase
ZHX2020_02135	COG1596	polysaccharide export
ZHX2020_02135	COG1555	photosystem II stabilization
ZHX2020_02140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZHX2020_02145	COG2226	methyltransferase
ZHX2020_02150	COG0799	negative regulation of ribosome biogenesis
ZHX2020_02155	COG1713	HD superfamily hydrolase involved in NAD metabolism
ZHX2020_02160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZHX2020_02165	COG1534	Rna-binding protein
ZHX2020_02170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ZHX2020_02175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ZHX2020_02180	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ZHX2020_02190	COG2755	lipolytic protein G-D-S-L family
ZHX2020_02195	COG5632	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_02195	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_02200	COG0398	Pfam SNARE associated Golgi protein
ZHX2020_02205	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ZHX2020_02215	COG3209	COG3209 Rhs family protein
ZHX2020_02235	COG0114	fumarate hydratase activity
ZHX2020_02240	COG0583	DNA-binding transcription factor activity
ZHX2020_02250	COG0457	Tetratricopeptide repeat
ZHX2020_02375	COG4978	Transcriptional regulator
ZHX2020_02375	COG0789	Transcriptional regulator
ZHX2020_02380	COG2814	Major facilitator Superfamily
ZHX2020_02385	COG0456	acetyltransferase
ZHX2020_02390	COG1253	flavin adenine dinucleotide binding
ZHX2020_02400	COG0697	spore germination
ZHX2020_02405	COG0583	DNA-binding transcription factor activity
ZHX2020_02410	COG2072	flavoprotein involved in K transport
ZHX2020_02415	COG1230	cation diffusion facilitator family transporter
ZHX2020_02425	COG1114	Component of the transport system for branched-chain amino acids
ZHX2020_02430	COG1687	branched-chain amino acid
ZHX2020_02440	COG1522	sequence-specific DNA binding
ZHX2020_02445	COG2732	(Barnase) inhibitor
ZHX2020_02450	COG2124	cytochrome p450
ZHX2020_02465	COG1335	isochorismatase
ZHX2020_02485	COG2318	DinB family
ZHX2020_02495	COG2070	2-Nitropropane dioxygenase
ZHX2020_02500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZHX2020_02520	COG3443	Belongs to the bacterial solute-binding protein 9 family
ZHX2020_02525	COG1595	DNA-templated transcription, initiation
ZHX2020_02530	COG0667	Aldo Keto reductase
ZHX2020_02535	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_02540	COG5566	PFAM Mor transcription activator
ZHX2020_02550	COG4991	sh3 domain protein
ZHX2020_02555	COG4991	sh3 domain protein
ZHX2020_02565	COG0346	lactoylglutathione lyase activity
ZHX2020_02575	COG5577	PFAM Coat F domain
ZHX2020_02580	COG1063	alcohol dehydrogenase
ZHX2020_02590	COG5577	PFAM Coat F domain
ZHX2020_02595	COG0789	Transcriptional regulator
ZHX2020_02605	COG1064	alcohol dehydrogenase
ZHX2020_02610	COG0693	protein deglycase activity
ZHX2020_02615	COG1621	beta-fructofuranosidase activity
ZHX2020_02620	COG3716	PTS system mannose fructose sorbose family IID component
ZHX2020_02625	COG3715	PTS system
ZHX2020_02630	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_02635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_02640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ZHX2020_02640	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ZHX2020_02650	COG1113	amino acid transport
ZHX2020_02655	COG1280	lysine exporter protein (LysE YggA)
ZHX2020_02660	COG1378	Sugar-specific transcriptional regulator TrmB
ZHX2020_02665	COG1595	DNA-templated transcription, initiation
ZHX2020_02690	COG1309	transcriptional regulator
ZHX2020_02695	COG2226	methyltransferase
ZHX2020_02710	COG2116	formate transmembrane transporter activity
ZHX2020_02715	COG5609	conserved protein (DUF2294)
ZHX2020_02720	COG3383	formate dehydrogenase (NAD+) activity
ZHX2020_02725	COG2427	Protein of unknown function (DUF1641)
ZHX2020_02740	COG0626	cystathionine gamma-synthase activity
ZHX2020_02745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ZHX2020_02750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ZHX2020_02755	COG2226	methyltransferase
ZHX2020_02770	COG0768	penicillin binding
ZHX2020_02775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZHX2020_02780	COG0572	uridine kinase
ZHX2020_02785	COG0826	peptidase U32
ZHX2020_02790	COG0826	peptidase U32
ZHX2020_02795	COG4122	O-methyltransferase activity
ZHX2020_02800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZHX2020_02805	COG3906	Belongs to the UPF0473 family
ZHX2020_02810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZHX2020_02815	COG4472	Bacterial protein of unknown function (DUF965)
ZHX2020_02820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZHX2020_02825	COG0628	permease
ZHX2020_02830	COG1126	abc transporter atp-binding protein
ZHX2020_02835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZHX2020_02840	COG0765	amino acid transport
ZHX2020_02845	COG0765	amino acid transport
ZHX2020_02860	COG3881	PFAM PRC-barrel domain
ZHX2020_02865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ZHX2020_02870	COG0457	Tetratricopeptide repeat
ZHX2020_02875	COG0482	sulfurtransferase activity
ZHX2020_02880	COG1104	cysteine desulfurase activity
ZHX2020_02885	COG1959	2 iron, 2 sulfur cluster binding
ZHX2020_02890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZHX2020_02895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ZHX2020_02905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZHX2020_02910	COG0124	histidyl-tRNA synthetase
ZHX2020_02920	COG3103	Sh3 type 3 domain protein
ZHX2020_02920	COG4991	sh3 domain protein
ZHX2020_02920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_02925	COG1490	D-aminoacyl-tRNA deacylase activity
ZHX2020_02930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ZHX2020_02935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ZHX2020_02940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZHX2020_02940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZHX2020_02945	COG5416	Lipopolysaccharide assembly protein A domain
ZHX2020_02950	COG0490	domain, Protein
ZHX2020_02955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZHX2020_02955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZHX2020_02965	COG2244	polysaccharide biosynthetic process
ZHX2020_02970	COG2323	membrane
ZHX2020_02980	COG1862	Preprotein translocase
ZHX2020_02985	COG0343	queuine tRNA-ribosyltransferase activity
ZHX2020_02990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZHX2020_03000	COG2255	four-way junction helicase activity
ZHX2020_03005	COG0632	four-way junction helicase activity
ZHX2020_03015	COG2814	Major facilitator Superfamily
ZHX2020_03020	COG0673	inositol 2-dehydrogenase activity
ZHX2020_03025	COG2112	serine threonine protein kinase
ZHX2020_03045	COG1115	amino acid carrier protein
ZHX2020_03050	COG0217	transcriptional regulatory protein
ZHX2020_03060	COG1388	LysM domain
ZHX2020_03065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ZHX2020_03070	COG0157	Belongs to the NadC ModD family
ZHX2020_03075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ZHX2020_03080	COG1104	cysteine desulfurase activity
ZHX2020_03085	COG1827	regulation of RNA biosynthetic process
ZHX2020_03090	COG0077	Prephenate dehydratase
ZHX2020_03095	COG4492	Belongs to the UPF0735 family
ZHX2020_03100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZHX2020_03105	COG3290	protein histidine kinase activity
ZHX2020_03115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZHX2020_03120	COG2868	ribosomal protein
ZHX2020_03125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZHX2020_03130	COG1994	Peptidase M50
ZHX2020_03135	COG0739	heme binding
ZHX2020_03140	COG2894	cell division
ZHX2020_03145	COG0850	regulation of cytokinetic process
ZHX2020_03150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ZHX2020_03160	COG1077	Cell shape determining protein MreB Mrl
ZHX2020_03165	COG2003	Belongs to the UPF0758 family
ZHX2020_03170	COG0424	maF-like protein
ZHX2020_03180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ZHX2020_03185	COG0285	dihydrofolate synthase activity
ZHX2020_03190	COG0525	valine-tRNA ligase activity
ZHX2020_03200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZHX2020_03205	COG1388	LysM domain
ZHX2020_03210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ZHX2020_03215	COG0113	porphobilinogen synthase activity
ZHX2020_03220	COG1587	Uroporphyrinogen-III synthase
ZHX2020_03225	COG0181	hydroxymethylbilane synthase activity
ZHX2020_03230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZHX2020_03235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ZHX2020_03245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZHX2020_03250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ZHX2020_03255	COG0470	DNA polymerase III
ZHX2020_03255	COG1067	ATP-dependent peptidase activity
ZHX2020_03260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZHX2020_03265	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZHX2020_03270	COG1477	protein flavinylation
ZHX2020_03270	COG0457	Tetratricopeptide repeat
ZHX2020_03275	COG0066	3-isopropylmalate dehydratase activity
ZHX2020_03280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZHX2020_03285	COG0473	3-isopropylmalate dehydrogenase activity
ZHX2020_03290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZHX2020_03295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZHX2020_03300	COG0440	acetolactate synthase activity
ZHX2020_03305	COG0028	Belongs to the TPP enzyme family
ZHX2020_03320	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ZHX2020_03345	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ZHX2020_03375	COG0622	Phosphoesterase
ZHX2020_03380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZHX2020_03385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ZHX2020_03390	COG5401	PFAM Sporulation and spore germination
ZHX2020_03395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZHX2020_03400	COG1846	Transcriptional regulator
ZHX2020_03405	COG2197	response regulator
ZHX2020_03410	COG0824	Thioesterase
ZHX2020_03415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ZHX2020_03420	COG1053	succinate dehydrogenase
ZHX2020_03425	COG2009	succinate dehydrogenase
ZHX2020_03430	COG1719	4-vinyl reductase, 4VR
ZHX2020_03435	COG0527	aspartate kinase activity
ZHX2020_03450	COG3118	belongs to the thioredoxin family
ZHX2020_03455	COG3534	alpha-L-arabinofuranosidase
ZHX2020_03460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ZHX2020_03465	COG2086	electron transfer activity
ZHX2020_03470	COG1024	Enoyl-CoA hydratase
ZHX2020_03475	COG1309	transcriptional regulator
ZHX2020_03480	COG0318	PFAM AMP-dependent synthetase and ligase
ZHX2020_03485	COG3766	membrane
ZHX2020_03490	COG1193	negative regulation of DNA recombination
ZHX2020_03495	COG1796	DNA polymerase
ZHX2020_03495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ZHX2020_03500	COG1286	toxin biosynthetic process
ZHX2020_03505	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ZHX2020_03510	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZHX2020_03515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZHX2020_03515	COG0072	phenylalanine-tRNA ligase activity
ZHX2020_03520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZHX2020_03530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZHX2020_03540	COG3835	regulator
ZHX2020_03545	COG0277	FAD linked oxidase domain protein
ZHX2020_03550	COG0247	lactate metabolic process
ZHX2020_03555	COG0346	lactoylglutathione lyase activity
ZHX2020_03560	COG1966	Carbon starvation protein
ZHX2020_03565	COG3534	alpha-L-arabinofuranosidase
ZHX2020_03570	COG0395	ABC-type sugar transport system, permease component
ZHX2020_03575	COG1175	transmembrane transport
ZHX2020_03580	COG1653	transport
ZHX2020_03585	COG0371	Dehydrogenase
ZHX2020_03590	COG0647	UMP catabolic process
ZHX2020_03595	COG0235	Class ii aldolase
ZHX2020_03600	COG1069	ribulokinase activity
ZHX2020_03605	COG2160	L-arabinose isomerase activity
ZHX2020_03615	COG1363	Peptidase, m42
ZHX2020_03625	COG3326	Membrane
ZHX2020_03630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZHX2020_03635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ZHX2020_03640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZHX2020_03650	COG1346	cytolysis
ZHX2020_03655	COG1380	Effector of murein hydrolase LrgA
ZHX2020_03660	COG3279	Response regulator of the LytR AlgR family
ZHX2020_03665	COG3275	phosphorelay sensor kinase activity
ZHX2020_03670	COG1011	Hydrolase
ZHX2020_03675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZHX2020_03685	COG0398	Pfam SNARE associated Golgi protein
ZHX2020_03690	COG1484	DNA-dependent DNA replication
ZHX2020_03695	COG3611	Membrane attachment protein
ZHX2020_03700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZHX2020_03705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ZHX2020_03710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZHX2020_03715	COG1733	regulation of RNA biosynthetic process
ZHX2020_03720	COG2814	Major facilitator Superfamily
ZHX2020_03725	COG0656	L-ascorbic acid biosynthetic process
ZHX2020_03730	COG0237	dephospho-CoA kinase activity
ZHX2020_03735	COG1971	Probably functions as a manganese efflux pump
ZHX2020_03740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ZHX2020_03745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZHX2020_03745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZHX2020_03750	COG5002	protein histidine kinase activity
ZHX2020_03755	COG0745	RESPONSE REGULATOR receiver
ZHX2020_03760	COG0039	L-malate dehydrogenase activity
ZHX2020_03765	COG0538	isocitrate dehydrogenase activity
ZHX2020_03770	COG0372	Belongs to the citrate synthase family
ZHX2020_03775	COG2707	UPF0756 membrane protein
ZHX2020_03780	COG0628	permease
ZHX2020_03785	COG3030	protein affecting phage T7 exclusion by the F plasmid
ZHX2020_03790	COG0469	pyruvate kinase activity
ZHX2020_03795	COG0205	6-phosphofructokinase activity
ZHX2020_03800	COG0825	malonyl-CoA metabolic process
ZHX2020_03805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZHX2020_03810	COG0281	malic enzyme
ZHX2020_03815	COG0587	DNA-directed DNA polymerase activity
ZHX2020_03835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ZHX2020_03845	COG4109	DRTGG domain
ZHX2020_03855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ZHX2020_03860	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_03865	COG0165	Argininosuccinate lyase
ZHX2020_03870	COG0137	argininosuccinate synthase activity
ZHX2020_03875	COG0521	Mo-molybdopterin cofactor biosynthetic process
ZHX2020_03880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ZHX2020_03890	COG0827	DNA restriction-modification system
ZHX2020_03895	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ZHX2020_03900	COG3874	Sporulation protein YtfJ
ZHX2020_03910	COG1714	RDD family
ZHX2020_03915	COG0616	signal peptide processing
ZHX2020_03920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZHX2020_03925	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ZHX2020_03930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ZHX2020_03940	COG0301	tRNA thio-modification
ZHX2020_03945	COG1104	cysteine desulfurase activity
ZHX2020_03950	COG1114	Component of the transport system for branched-chain amino acids
ZHX2020_03955	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ZHX2020_03960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ZHX2020_03965	COG1309	transcriptional regulator
ZHX2020_03970	COG1956	GAF domain-containing protein
ZHX2020_03975	COG2203	Gaf domain
ZHX2020_03975	COG2199	diguanylate cyclase activity
ZHX2020_03980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZHX2020_03985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZHX2020_03990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ZHX2020_03995	COG0454	-acetyltransferase
ZHX2020_04000	COG0517	IMP dehydrogenase activity
ZHX2020_04005	COG0123	including yeast histone deacetylase and acetoin utilization protein
ZHX2020_04010	COG1360	Flagellar Motor Protein
ZHX2020_04015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ZHX2020_04020	COG1609	Transcriptional regulator
ZHX2020_04025	COG1605	Chorismate mutase
ZHX2020_04025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ZHX2020_04030	COG3118	belongs to the thioredoxin family
ZHX2020_04035	COG4980	gas vesicle protein
ZHX2020_04040	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ZHX2020_04045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZHX2020_04050	COG1674	ftsk spoiiie
ZHX2020_04055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZHX2020_04060	COG4848	Belongs to the UPF0354 family
ZHX2020_04065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_04080	COG1363	Peptidase, m42
ZHX2020_04085	COG5584	Small secreted protein
ZHX2020_04090	COG0281	malic enzyme
ZHX2020_04095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZHX2020_04100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZHX2020_04110	COG0510	thiamine kinase activity
ZHX2020_04115	COG1523	belongs to the glycosyl hydrolase 13 family
ZHX2020_04120	COG1597	lipid kinase activity
ZHX2020_04130	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ZHX2020_04135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ZHX2020_04140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZHX2020_04145	COG2252	PERMEase
ZHX2020_04150	COG4473	ABC transporter
ZHX2020_04155	COG1131	(ABC) transporter
ZHX2020_04160	COG1349	DNA-binding transcription factor activity
ZHX2020_04165	COG1187	pseudouridine synthase activity
ZHX2020_04170	COG2244	polysaccharide biosynthetic process
ZHX2020_04175	COG2081	HI0933 family
ZHX2020_04180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ZHX2020_04200	COG1653	transport
ZHX2020_04205	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ZHX2020_04210	COG4209	transmembrane transport
ZHX2020_04220	COG1653	transport
ZHX2020_04225	COG0395	ABC-type sugar transport system, permease component
ZHX2020_04230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZHX2020_04235	COG2124	cytochrome p450
ZHX2020_04255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZHX2020_04265	COG1073	alpha beta
ZHX2020_04270	COG1609	Transcriptional regulator
ZHX2020_04275	COG1653	transport
ZHX2020_04280	COG1175	transmembrane transport
ZHX2020_04285	COG0395	ABC-type sugar transport system, permease component
ZHX2020_04290	COG1486	melibiose metabolic process
ZHX2020_04295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZHX2020_04300	COG0495	leucyl-tRNA aminoacylation
ZHX2020_04310	COG2202	Pas domain
ZHX2020_04310	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_04315	COG2814	Major facilitator Superfamily
ZHX2020_04320	COG2433	Pfam Transposase IS66
ZHX2020_04325	COG0577	efflux transmembrane transporter activity
ZHX2020_04330	COG1136	(ABC) transporter
ZHX2020_04335	COG2205	protein histidine kinase activity
ZHX2020_04340	COG0745	RESPONSE REGULATOR receiver
ZHX2020_04345	COG0577	efflux transmembrane transporter activity
ZHX2020_04350	COG1136	(ABC) transporter
ZHX2020_04365	COG1131	(ABC) transporter
ZHX2020_04370	COG1725	Transcriptional regulator
ZHX2020_04385	COG1242	4 iron, 4 sulfur cluster binding
ZHX2020_04390	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ZHX2020_04400	COG2267	carboxylic ester hydrolase activity
ZHX2020_04405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ZHX2020_04410	COG1113	amino acid transport
ZHX2020_04415	COG0367	asparagine synthase
ZHX2020_04420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZHX2020_04425	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ZHX2020_04435	COG1506	peptidase
ZHX2020_04440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ZHX2020_04445	COG1116	anion transmembrane transporter activity
ZHX2020_04450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZHX2020_04455	COG0494	nUDIX hydrolase
ZHX2020_04460	COG4824	toxin secretion phage lysis holin
ZHX2020_04465	COG0783	Belongs to the Dps family
ZHX2020_04480	COG1854	S-ribosylhomocysteine lyase activity
ZHX2020_04485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ZHX2020_04490	COG0288	reversible hydration of carbon dioxide
ZHX2020_04495	COG0254	rRNA binding
ZHX2020_04500	COG1271	oxidase subunit
ZHX2020_04505	COG1294	oxidase, subunit
ZHX2020_04515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZHX2020_04520	COG1321	iron dependent repressor
ZHX2020_04520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZHX2020_04525	COG1121	(ABC) transporter
ZHX2020_04530	COG0803	Belongs to the bacterial solute-binding protein 9 family
ZHX2020_04535	COG4948	Mandelate Racemase Muconate Lactonizing
ZHX2020_04540	COG0318	PFAM AMP-dependent synthetase and ligase
ZHX2020_04545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ZHX2020_04550	COG0596	Alpha beta hydrolase
ZHX2020_04555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ZHX2020_04560	COG1169	isochorismate synthase
ZHX2020_04565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ZHX2020_04570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZHX2020_04575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZHX2020_04580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZHX2020_04585	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_04595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZHX2020_04600	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_04605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZHX2020_04610	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ZHX2020_04615	COG0058	SHG alpha-glucan phosphorylase activity
ZHX2020_04620	COG0297	glycogen (starch) synthase activity
ZHX2020_04625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ZHX2020_04630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ZHX2020_04635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ZHX2020_04760	COG3859	Proton-coupled thiamine transporter YuaJ
ZHX2020_04765	COG1247	-acetyltransferase
ZHX2020_04770	COG2268	Band 7 protein
ZHX2020_04775	COG1585	Membrane protein implicated in regulation of membrane protease activity
ZHX2020_04780	COG2318	DinB family
ZHX2020_04790	COG1454	alcohol dehydrogenase
ZHX2020_04795	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_04800	COG1510	regulation of RNA biosynthetic process
ZHX2020_04810	COG0569	domain protein
ZHX2020_04815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZHX2020_04820	COG4682	membrane
ZHX2020_04825	COG1705	Flagellar rod assembly protein muramidase FlgJ
ZHX2020_04830	COG0477	Major facilitator Superfamily
ZHX2020_04835	COG5553	Cysteine dioxygenase type I
ZHX2020_04845	COG1968	undecaprenyl-diphosphatase activity
ZHX2020_04850	COG0628	permease
ZHX2020_04855	COG0673	inositol 2-dehydrogenase activity
ZHX2020_04860	COG4806	L-rhamnose isomerase
ZHX2020_04865	COG3254	rhamnose metabolic process
ZHX2020_04870	COG1070	Carbohydrate kinase
ZHX2020_04875	COG1349	DNA-binding transcription factor activity
ZHX2020_04880	COG3347	Dehydrogenase
ZHX2020_04880	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_04890	COG0840	transmembrane signaling receptor activity
ZHX2020_04900	COG0840	transmembrane signaling receptor activity
ZHX2020_04915	COG0432	Pfam Uncharacterised protein family UPF0047
ZHX2020_04925	COG0366	Alpha amylase catalytic
ZHX2020_04930	COG1253	flavin adenine dinucleotide binding
ZHX2020_04935	COG2738	Putative neutral zinc metallopeptidase
ZHX2020_04950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ZHX2020_04965	COG0166	Belongs to the GPI family
ZHX2020_04970	COG1979	alcohol dehydrogenase
ZHX2020_04975	COG1979	alcohol dehydrogenase
ZHX2020_04980	COG2155	Conserved Protein
ZHX2020_04985	COG1098	S1 RNA binding domain
ZHX2020_04990	COG0436	Aminotransferase
ZHX2020_04995	COG1522	sequence-specific DNA binding
ZHX2020_05000	COG2267	carboxylic ester hydrolase activity
ZHX2020_05010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ZHX2020_05015	COG2205	protein histidine kinase activity
ZHX2020_05025	COG5018	Exonuclease
ZHX2020_05030	COG2814	Major facilitator Superfamily
ZHX2020_05035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZHX2020_05040	COG3011	Protein conserved in bacteria
ZHX2020_05050	COG3290	protein histidine kinase activity
ZHX2020_05055	COG4565	transcriptional regulatory protein
ZHX2020_05060	COG1744	ABC transporter substrate-binding protein PnrA-like
ZHX2020_05065	COG3845	ABC transporter
ZHX2020_05070	COG4603	Belongs to the binding-protein-dependent transport system permease family
ZHX2020_05075	COG1079	Belongs to the binding-protein-dependent transport system permease family
ZHX2020_05080	COG3493	citrate carrier protein
ZHX2020_05090	COG2111	Na H antiporter
ZHX2020_05090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ZHX2020_05095	COG2111	Na H antiporter
ZHX2020_05100	COG1006	Multisubunit Na H antiporter MnhC subunit
ZHX2020_05105	COG0651	ATP synthesis coupled electron transport
ZHX2020_05110	COG1863	multisubunit Na H antiporter MnhE subunit
ZHX2020_05115	COG2212	antiporter activity
ZHX2020_05120	COG1320	monovalent cation:proton antiporter activity
ZHX2020_05125	COG2050	protein possibly involved in aromatic compounds catabolism
ZHX2020_05130	COG2197	response regulator
ZHX2020_05135	COG4585	Histidine kinase
ZHX2020_05145	COG0142	geranyltranstransferase activity
ZHX2020_05165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ZHX2020_05170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ZHX2020_05175	COG1335	isochorismatase
ZHX2020_05180	COG5506	Protein of unknown function (DUF1694)
ZHX2020_05195	COG0628	permease
ZHX2020_05210	COG1418	mRNA catabolic process
ZHX2020_05215	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_05225	COG1511	domain protein
ZHX2020_05230	COG1674	ftsk spoiiie
ZHX2020_05230	COG0433	COG0433 Predicted ATPase
ZHX2020_05235	COG4499	WXG100 protein secretion system (Wss), protein YukC
ZHX2020_05240	COG5417	Belongs to the EsaB family
ZHX2020_05245	COG4842	Belongs to the WXG100 family
ZHX2020_05250	COG2508	Transcriptional regulator
ZHX2020_05250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ZHX2020_05255	COG0686	Belongs to the AlaDH PNT family
ZHX2020_05260	COG5634	Uncharacterized conserved protein (DUF2278)
ZHX2020_05265	COG3251	PFAM MbtH domain protein
ZHX2020_05270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZHX2020_05275	COG1535	isochorismatase
ZHX2020_05275	COG3433	isochorismatase activity
ZHX2020_05280	COG1021	2,3-dihydroxybenzoate-AMP ligase
ZHX2020_05285	COG1169	isochorismate synthase
ZHX2020_05290	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_05295	COG2819	hydrolase of the alpha beta superfamily
ZHX2020_05300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ZHX2020_05305	COG1268	BioY protein
ZHX2020_05310	COG2056	Na+-H+ antiporter family
ZHX2020_05315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZHX2020_05320	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ZHX2020_05325	COG3584	3D domain protein
ZHX2020_05340	COG1252	NADH dehydrogenase
ZHX2020_05345	COG0492	ferredoxin-NADP+ reductase activity
ZHX2020_05355	COG0516	GMP reductase activity
ZHX2020_05360	COG2808	Putative FMN-binding domain
ZHX2020_05365	COG0456	acetyltransferase
ZHX2020_05475	COG0582	viral genome integration into host DNA
ZHX2020_05485	COG4974	Belongs to the 'phage' integrase family
ZHX2020_05490	COG0316	Belongs to the HesB IscA family
ZHX2020_05495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZHX2020_05500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZHX2020_05505	COG4844	belongs to the
ZHX2020_05510	COG1252	NADH dehydrogenase
ZHX2020_05515	COG4837	Protein of unknown function (DUF1462)
ZHX2020_05520	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ZHX2020_05525	COG4946	Tricorn protease homolog
ZHX2020_05525	COG1506	peptidase
ZHX2020_05525	COG0823	Involved in the tonB-independent uptake of proteins
ZHX2020_05530	COG0083	homoserine kinase activity
ZHX2020_05535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ZHX2020_05540	COG0460	homoserine dehydrogenase
ZHX2020_05545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZHX2020_05550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ZHX2020_05555	COG0647	UMP catabolic process
ZHX2020_05560	COG2445	Protein of unknown function DUF86
ZHX2020_05565	COG4470	Protein conserved in bacteria
ZHX2020_05575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZHX2020_05580	COG0739	heme binding
ZHX2020_05590	COG3377	Domain of unknown function (DUF1805)
ZHX2020_05595	COG0737	Belongs to the 5'-nucleotidase family
ZHX2020_05600	COG0730	response to heat
ZHX2020_05605	COG1801	Protein of unknown function DUF72
ZHX2020_05615	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZHX2020_05620	COG2508	Transcriptional regulator
ZHX2020_05625	COG2233	PERMEase
ZHX2020_05630	COG2233	PERMEase
ZHX2020_05635	COG3195	allantoin biosynthetic process
ZHX2020_05635	COG3648	Uricase
ZHX2020_05640	COG2351	hydroxyisourate hydrolase activity
ZHX2020_05650	COG2080	2 iron, 2 sulfur cluster binding
ZHX2020_05655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ZHX2020_05660	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ZHX2020_05665	COG2068	MobA-Related Protein
ZHX2020_05670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ZHX2020_05675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ZHX2020_05680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZHX2020_05690	COG2356	endonuclease I
ZHX2020_05695	COG3842	ATPase activity
ZHX2020_05700	COG2188	Transcriptional regulator
ZHX2020_05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZHX2020_05715	COG1175	transmembrane transport
ZHX2020_05720	COG1653	transport
ZHX2020_05725	COG2222	sugar isomerase
ZHX2020_05730	COG0322	excinuclease ABC activity
ZHX2020_05735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZHX2020_05750	COG0346	lactoylglutathione lyase activity
ZHX2020_05755	COG0640	Transcriptional regulator
ZHX2020_05760	COG0719	Fe-S assembly protein
ZHX2020_05765	COG0822	iron-sulfur transferase activity
ZHX2020_05770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZHX2020_05775	COG0719	Fe-S assembly protein
ZHX2020_05780	COG0396	ATPase activity
ZHX2020_05795	COG1464	Belongs to the NlpA lipoprotein family
ZHX2020_05800	COG2011	ABC-type metal ion transport system permease component
ZHX2020_05805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ZHX2020_05815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_05820	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ZHX2020_05830	COG0509	glycine decarboxylation via glycine cleavage system
ZHX2020_05835	COG1393	Belongs to the ArsC family
ZHX2020_05840	COG1960	acyl-CoA dehydrogenase activity
ZHX2020_05845	COG0183	Belongs to the thiolase family
ZHX2020_05850	COG1024	Enoyl-CoA hydratase
ZHX2020_05850	COG1250	3-hydroxyacyl-CoA dehydrogenase
ZHX2020_05870	COG5577	PFAM Coat F domain
ZHX2020_05875	COG1846	Transcriptional regulator
ZHX2020_05880	COG0477	Major facilitator Superfamily
ZHX2020_05885	COG1942	4-Oxalocrotonate Tautomerase
ZHX2020_05890	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_05895	COG0583	DNA-binding transcription factor activity
ZHX2020_05905	COG1120	ATPase activity
ZHX2020_05925	COG1131	(ABC) transporter
ZHX2020_05970	COG0783	Belongs to the Dps family
ZHX2020_05975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZHX2020_05980	COG0745	RESPONSE REGULATOR receiver
ZHX2020_05985	COG2205	protein histidine kinase activity
ZHX2020_05985	COG2770	Histidine kinase
ZHX2020_05995	COG1309	transcriptional regulator
ZHX2020_06000	COG0114	fumarate hydratase activity
ZHX2020_06010	COG0697	spore germination
ZHX2020_06015	COG0814	amino acid
ZHX2020_06025	COG2197	response regulator
ZHX2020_06030	COG4585	Histidine kinase
ZHX2020_06035	COG4758	membrane
ZHX2020_06040	COG3595	metallopeptidase activity
ZHX2020_06045	COG1842	Phage shock protein A
ZHX2020_06050	COG4758	membrane
ZHX2020_06055	COG2814	Major facilitator Superfamily
ZHX2020_06060	COG2096	Adenosyltransferase
ZHX2020_06065	COG1120	ATPase activity
ZHX2020_06070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_06075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZHX2020_06080	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_06085	COG3386	PFAM SMP-30 Gluconolaconase
ZHX2020_06090	COG2205	protein histidine kinase activity
ZHX2020_06095	COG0745	RESPONSE REGULATOR receiver
ZHX2020_06115	COG2140	Oxalate decarboxylase
ZHX2020_06125	COG0577	efflux transmembrane transporter activity
ZHX2020_06130	COG1136	(ABC) transporter
ZHX2020_06135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZHX2020_06140	COG1120	ATPase activity
ZHX2020_06145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_06150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_06155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZHX2020_06160	COG0531	amino acid
ZHX2020_06170	COG1988	membrane-bound metal-dependent
ZHX2020_06175	COG1368	sulfuric ester hydrolase activity
ZHX2020_06180	COG1910	domain protein
ZHX2020_06185	COG0725	ABC transporter, periplasmic molybdate-binding protein
ZHX2020_06190	COG4149	molybdate abc transporter
ZHX2020_06195	COG0656	L-ascorbic acid biosynthetic process
ZHX2020_06205	COG0025	NhaP-type Na H and K H
ZHX2020_06210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZHX2020_06215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ZHX2020_06220	COG3973	AAA domain
ZHX2020_06230	COG2860	membrane
ZHX2020_06235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ZHX2020_06240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ZHX2020_06245	COG2217	Heavy metal translocating P-type atpase
ZHX2020_06250	COG2217	Heavy metal translocating P-type atpase
ZHX2020_06255	COG2608	mercury ion transmembrane transporter activity
ZHX2020_06260	COG1937	Protein conserved in bacteria
ZHX2020_06265	COG0673	inositol 2-dehydrogenase activity
ZHX2020_06275	COG1289	transmembrane transporter activity
ZHX2020_06285	COG2076	Multidrug Resistance protein
ZHX2020_06290	COG1309	transcriptional regulator
ZHX2020_06295	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_06305	COG5444	nuclease activity
ZHX2020_06320	COG5632	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_06320	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_06325	COG4824	toxin secretion phage lysis holin
ZHX2020_06350	COG3942	CHAP domain
ZHX2020_06350	COG1705	Flagellar rod assembly protein muramidase FlgJ
ZHX2020_06590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZHX2020_06595	COG0557	exoribonuclease II activity
ZHX2020_06600	COG1647	Serine aminopeptidase, S33
ZHX2020_06605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ZHX2020_06610	COG0596	Alpha beta hydrolase
ZHX2020_06615	COG1476	TRANSCRIPTIONal
ZHX2020_06620	COG1396	sequence-specific DNA binding
ZHX2020_06625	COG1396	sequence-specific DNA binding
ZHX2020_06630	COG1733	regulation of RNA biosynthetic process
ZHX2020_06635	COG0840	transmembrane signaling receptor activity
ZHX2020_06640	COG1174	glycine betaine transport
ZHX2020_06645	COG1732	Glycine betaine
ZHX2020_06650	COG1174	glycine betaine transport
ZHX2020_06655	COG1125	glycine betaine transport
ZHX2020_06655	COG0517	IMP dehydrogenase activity
ZHX2020_06660	COG1510	regulation of RNA biosynthetic process
ZHX2020_06665	COG1174	glycine betaine transport
ZHX2020_06670	COG1732	Glycine betaine
ZHX2020_06675	COG1174	glycine betaine transport
ZHX2020_06680	COG0517	IMP dehydrogenase activity
ZHX2020_06680	COG1125	glycine betaine transport
ZHX2020_06685	COG1510	regulation of RNA biosynthetic process
ZHX2020_06690	COG2095	MarC family integral membrane protein
ZHX2020_06700	COG3064	Membrane
ZHX2020_06705	COG4640	response to antibiotic
ZHX2020_06710	COG0456	acetyltransferase
ZHX2020_06715	COG0148	phosphopyruvate hydratase activity
ZHX2020_06720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ZHX2020_06725	COG0149	triose-phosphate isomerase activity
ZHX2020_06730	COG0126	phosphoglycerate kinase activity
ZHX2020_06735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZHX2020_06740	COG2390	Transcriptional regulator
ZHX2020_06745	COG2814	Major facilitator Superfamily
ZHX2020_06750	COG1609	Transcriptional regulator
ZHX2020_06755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZHX2020_06760	COG0583	DNA-binding transcription factor activity
ZHX2020_06765	COG0697	spore germination
ZHX2020_06770	COG1113	amino acid transport
ZHX2020_06780	COG1556	Lactate utilization protein
ZHX2020_06785	COG1139	Iron-sulfur cluster binding protein
ZHX2020_06790	COG0247	lactate metabolic process
ZHX2020_06795	COG2197	response regulator
ZHX2020_06800	COG4585	Histidine kinase
ZHX2020_06805	COG0842	Transport permease protein
ZHX2020_06810	COG1131	(ABC) transporter
ZHX2020_06830	COG0596	Alpha beta hydrolase
ZHX2020_06835	COG2208	phosphoserine phosphatase activity
ZHX2020_06840	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ZHX2020_06845	COG1874	Beta-galactosidase
ZHX2020_06850	COG3833	ABC-type maltose transport systems, permease component
ZHX2020_06855	COG1175	transmembrane transport
ZHX2020_06860	COG2182	Extracellular solute-binding protein
ZHX2020_06865	COG1609	Transcriptional regulator
ZHX2020_06870	COG2186	Transcriptional regulator
ZHX2020_06875	COG1620	l-lactate permease
ZHX2020_06880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZHX2020_06890	COG5039	Polysaccharide pyruvyl transferase
ZHX2020_06895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ZHX2020_06900	COG0110	maltose O-acetyltransferase activity
ZHX2020_06905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ZHX2020_06910	COG2244	polysaccharide biosynthetic process
ZHX2020_06915	COG1216	Glycosyl transferase, family 2
ZHX2020_06920	COG5039	Polysaccharide pyruvyl transferase
ZHX2020_06925	COG1216	Glycosyl transferase, family 2
ZHX2020_06935	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_06940	COG1215	transferase activity, transferring glycosyl groups
ZHX2020_06945	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_06950	COG1086	Polysaccharide biosynthesis protein
ZHX2020_06955	COG0489	protein tyrosine kinase activity
ZHX2020_06960	COG3944	biosynthesis protein
ZHX2020_06965	COG1396	sequence-specific DNA binding
ZHX2020_06970	COG2272	Belongs to the type-B carboxylesterase lipase family
ZHX2020_06980	COG3479	Phenolic acid decarboxylase
ZHX2020_06995	COG1794	racemase activity, acting on amino acids and derivatives
ZHX2020_07005	COG1621	beta-fructofuranosidase activity
ZHX2020_07010	COG1621	beta-fructofuranosidase activity
ZHX2020_07015	COG0531	amino acid
ZHX2020_07020	COG1309	transcriptional regulator
ZHX2020_07025	COG2076	Multidrug Resistance protein
ZHX2020_07030	COG2076	Multidrug Resistance protein
ZHX2020_07050	COG1674	ftsk spoiiie
ZHX2020_07070	COG1388	LysM domain
ZHX2020_07070	COG5632	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_07070	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_07105	COG1705	Flagellar rod assembly protein muramidase FlgJ
ZHX2020_07185	COG0582	viral genome integration into host DNA
ZHX2020_07295	COG4974	Belongs to the 'phage' integrase family
ZHX2020_07305	COG0740	serine-type endopeptidase activity
ZHX2020_07310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZHX2020_07315	COG0366	Alpha amylase catalytic
ZHX2020_07320	COG1554	hydrolase, family 65, central catalytic
ZHX2020_07325	COG5521	maltodextrose utilization protein MalA
ZHX2020_07330	COG3833	ABC-type maltose transport systems, permease component
ZHX2020_07335	COG1175	transmembrane transport
ZHX2020_07340	COG2182	Extracellular solute-binding protein
ZHX2020_07350	COG1609	Transcriptional regulator
ZHX2020_07355	COG1611	Belongs to the LOG family
ZHX2020_07365	COG0659	secondary active sulfate transmembrane transporter activity
ZHX2020_07370	COG0288	reversible hydration of carbon dioxide
ZHX2020_07375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZHX2020_07380	COG0577	efflux transmembrane transporter activity
ZHX2020_07385	COG1136	(ABC) transporter
ZHX2020_07390	COG5002	protein histidine kinase activity
ZHX2020_07395	COG0745	RESPONSE REGULATOR receiver
ZHX2020_07405	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ZHX2020_07410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_07415	COG1481	regulation of sporulation
ZHX2020_07420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ZHX2020_07425	COG1660	Displays ATPase and GTPase activities
ZHX2020_07430	COG1051	belongs to the nudix hydrolase family
ZHX2020_07435	COG0492	ferredoxin-NADP+ reductase activity
ZHX2020_07440	COG0791	NLP P60 protein
ZHX2020_07440	COG3883	PFAM NLP P60 protein
ZHX2020_07445	COG0457	Tetratricopeptide repeat
ZHX2020_07450	COG1132	(ABC) transporter
ZHX2020_07470	COG0140	phosphoribosyl-ATP diphosphatase activity
ZHX2020_07470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZHX2020_07475	COG0107	imidazoleglycerol-phosphate synthase activity
ZHX2020_07480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZHX2020_07485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZHX2020_07490	COG0131	Imidazoleglycerol-phosphate dehydratase
ZHX2020_07495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZHX2020_07500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZHX2020_07505	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ZHX2020_07510	COG4990	cell redox homeostasis
ZHX2020_07515	COG5297	Belongs to the glycosyl hydrolase family 6
ZHX2020_07530	COG0546	phosphoglycolate phosphatase activity
ZHX2020_07535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ZHX2020_07540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZHX2020_07545	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ZHX2020_07550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ZHX2020_07555	COG0363	glucosamine-6-phosphate deaminase activity
ZHX2020_07560	COG2188	Transcriptional regulator
ZHX2020_07565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ZHX2020_07575	COG1950	PFAM Membrane protein of
ZHX2020_07580	COG1983	PspC domain protein
ZHX2020_07585	COG3595	metallopeptidase activity
ZHX2020_07600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ZHX2020_07605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZHX2020_07610	COG0556	nucleotide-excision repair
ZHX2020_07615	COG4897	Protein conserved in bacteria
ZHX2020_07620	COG0574	Belongs to the PEP-utilizing enzyme family
ZHX2020_07620	COG3848	Pyruvate phosphate dikinase
ZHX2020_07625	COG1309	transcriptional regulator
ZHX2020_07630	COG2814	Major facilitator Superfamily
ZHX2020_07635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZHX2020_07645	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_07645	COG0793	Belongs to the peptidase S41A family
ZHX2020_07650	COG2177	Part of the ABC transporter FtsEX involved in
ZHX2020_07655	COG2884	Cell division ATP-binding protein ftsE
ZHX2020_07660	COG2010	Cytochrome c
ZHX2020_07665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZHX2020_07675	COG0653	protein targeting
ZHX2020_07680	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ZHX2020_07695	COG1516	flagellar protein fliS
ZHX2020_07700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ZHX2020_07705	COG1334	flagellar protein FlaG
ZHX2020_07710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ZHX2020_07715	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ZHX2020_07720	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ZHX2020_07730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ZHX2020_07735	COG4786	Flagellar basal body rod
ZHX2020_07735	COG1256	bacterial-type flagellum assembly
ZHX2020_07740	COG3418	PFAM FlgN family protein
ZHX2020_07745	COG2747	anti-sigma28 factor FlgM
ZHX2020_07755	COG1040	competence protein
ZHX2020_07765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ZHX2020_07770	COG1307	EDD domain protein, DegV family
ZHX2020_07775	COG2197	response regulator
ZHX2020_07780	COG4585	Histidine kinase
ZHX2020_07785	COG1739	Uncharacterized protein family UPF0029
ZHX2020_07790	COG1316	TRANSCRIPTIONal
ZHX2020_07820	COG1131	(ABC) transporter
ZHX2020_07830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZHX2020_07835	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_07840	COG1215	transferase activity, transferring glycosyl groups
ZHX2020_07845	COG3206	protein involved in exopolysaccharide biosynthesis
ZHX2020_07850	COG3307	-O-antigen
ZHX2020_07855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZHX2020_07860	COG0297	glycogen (starch) synthase activity
ZHX2020_07860	COG0438	transferase activity, transferring glycosyl groups
ZHX2020_07865	COG2244	polysaccharide biosynthetic process
ZHX2020_07880	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_07880	COG2247	cell wall binding repeat
ZHX2020_07885	COG2385	sporulation resulting in formation of a cellular spore
ZHX2020_07885	COG2247	cell wall binding repeat
ZHX2020_07910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ZHX2020_07915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZHX2020_07925	COG1134	teichoic acid transport
ZHX2020_07930	COG1682	transport, permease protein
ZHX2020_07945	COG0463	Glycosyl transferase, family 2
ZHX2020_07945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ZHX2020_07950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ZHX2020_07955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ZHX2020_07960	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ZHX2020_07965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ZHX2020_07970	COG4193	domain, Protein
ZHX2020_07975	COG1482	cell wall glycoprotein biosynthetic process
ZHX2020_07980	COG0697	spore germination
ZHX2020_07985	COG0814	amino acid
ZHX2020_08000	COG1316	TRANSCRIPTIONal
ZHX2020_08005	COG0561	phosphatase activity
ZHX2020_08010	COG0791	NLP P60 protein
ZHX2020_08020	COG2843	Capsule synthesis protein
ZHX2020_08030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZHX2020_08035	COG1609	Transcriptional regulator
ZHX2020_08040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZHX2020_08045	COG1869	D-ribose catabolic process
ZHX2020_08050	COG1129	ABC transporter
ZHX2020_08055	COG1172	Belongs to the binding-protein-dependent transport system permease family
ZHX2020_08060	COG1879	ABC-type sugar transport system periplasmic component
ZHX2020_08065	COG3103	Sh3 type 3 domain protein
ZHX2020_08075	COG2249	NAD(P)H dehydrogenase (quinone) activity
ZHX2020_08080	COG3527	Alpha-acetolactate decarboxylase
ZHX2020_08085	COG0028	Belongs to the TPP enzyme family
ZHX2020_08090	COG0583	DNA-binding transcription factor activity
ZHX2020_08095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ZHX2020_08110	COG5337	Spore coat protein CotH
ZHX2020_08120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ZHX2020_08130	COG0405	Gamma-glutamyltransferase
ZHX2020_08135	COG1522	sequence-specific DNA binding
ZHX2020_08140	COG2059	Chromate
ZHX2020_08145	COG2059	Chromate
ZHX2020_08155	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZHX2020_08160	COG0583	DNA-binding transcription factor activity
ZHX2020_08190	COG5444	nuclease activity
ZHX2020_08215	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZHX2020_08220	COG4464	protein tyrosine phosphatase activity
ZHX2020_08225	COG0489	protein tyrosine kinase activity
ZHX2020_08230	COG3944	biosynthesis protein
ZHX2020_08240	COG4715	Zinc finger, swim domain protein
ZHX2020_08245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ZHX2020_08250	COG0561	phosphatase activity
ZHX2020_08255	COG1349	DNA-binding transcription factor activity
ZHX2020_08260	COG0629	single-stranded DNA binding
ZHX2020_08275	COG3764	Sortase (surface protein transpeptidase)
ZHX2020_08285	COG2972	Histidine kinase
ZHX2020_08285	COG0745	RESPONSE REGULATOR receiver
ZHX2020_08290	COG1970	mechanosensitive ion channel activity
ZHX2020_08295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZHX2020_08300	COG0457	Tetratricopeptide repeat
ZHX2020_08305	COG4786	Flagellar basal body rod
ZHX2020_08310	COG4786	Flagellar basal body rod
ZHX2020_08315	COG1077	Cell shape determining protein MreB Mrl
ZHX2020_08320	COG1609	Transcriptional regulator
ZHX2020_08330	COG1846	Transcriptional regulator
ZHX2020_08335	COG2814	Major facilitator Superfamily
ZHX2020_08340	COG3420	alginic acid biosynthetic process
ZHX2020_08345	COG1953	Uracil, thiamine, allantoin
ZHX2020_08350	COG0477	Major facilitator Superfamily
ZHX2020_08355	COG1335	isochorismatase
ZHX2020_08365	COG0004	ammonium transporteR
ZHX2020_08370	COG0347	Belongs to the P(II) protein family
ZHX2020_08375	COG0671	phosphoesterase, PA-phosphatase related
ZHX2020_08385	COG0739	heme binding
ZHX2020_08390	COG1247	-acetyltransferase
ZHX2020_08400	COG2089	acid synthase
ZHX2020_08410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZHX2020_08415	COG0789	Transcriptional regulator
ZHX2020_08425	COG2910	NAD(P)H-binding
ZHX2020_08430	COG1959	2 iron, 2 sulfur cluster binding
ZHX2020_08435	COG0804	urea catabolic process
ZHX2020_08440	COG0832	Belongs to the urease beta subunit family
ZHX2020_08445	COG0831	urea catabolic process
ZHX2020_08460	COG3237	CsbD-like
ZHX2020_08465	COG1994	Peptidase M50
ZHX2020_08470	COG0457	Tetratricopeptide repeat
ZHX2020_08475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ZHX2020_08480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ZHX2020_08490	COG2304	oxidoreductase activity
ZHX2020_08500	COG2304	oxidoreductase activity
ZHX2020_08505	COG2385	sporulation resulting in formation of a cellular spore
ZHX2020_08510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZHX2020_08520	COG4836	Membrane
ZHX2020_08530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZHX2020_08535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZHX2020_08540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZHX2020_08545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZHX2020_08550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZHX2020_08555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZHX2020_08565	COG0356	it plays a direct role in the translocation of protons across the membrane
ZHX2020_08575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ZHX2020_08580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZHX2020_08585	COG4475	Protein of unknown function (DUF436)
ZHX2020_08590	COG0698	ribose 5-phosphate isomerase
ZHX2020_08595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZHX2020_08600	COG1971	Probably functions as a manganese efflux pump
ZHX2020_08605	COG0009	L-threonylcarbamoyladenylate synthase
ZHX2020_08610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ZHX2020_08630	COG2890	protein-(glutamine-N5) methyltransferase activity
ZHX2020_08635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZHX2020_08640	COG0346	lactoylglutathione lyase activity
ZHX2020_08645	COG0789	Transcriptional regulator
ZHX2020_08650	COG0679	Auxin Efflux Carrier
ZHX2020_08655	COG0281	malic enzyme
ZHX2020_08660	COG1435	thymidine kinase activity
ZHX2020_08670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ZHX2020_08680	COG1494	fructose-1,6-bisphosphatase
ZHX2020_08685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZHX2020_08695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ZHX2020_08700	COG0191	fructose-bisphosphate aldolase activity
ZHX2020_08705	COG2204	response regulator
ZHX2020_08710	COG4821	SIS domain
ZHX2020_08715	COG0504	CTP synthase activity
ZHX2020_08720	COG3343	RNA polymerase activity
ZHX2020_08725	COG1960	acyl-CoA dehydrogenase activity
ZHX2020_08730	COG0247	lactate metabolic process
ZHX2020_08730	COG2181	nitrate reductase activity
ZHX2020_08735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZHX2020_08740	COG4294	response to UV
ZHX2020_08750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZHX2020_08760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZHX2020_08770	COG2181	nitrate reductase activity
ZHX2020_08775	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ZHX2020_08780	COG1140	nitrate reductase beta subunit
ZHX2020_08785	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ZHX2020_08790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ZHX2020_08800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ZHX2020_08805	COG2223	nitrite transmembrane transporter activity
ZHX2020_08810	COG0018	arginyl-trna synthetase
ZHX2020_08815	COG4506	Protein conserved in bacteria
ZHX2020_08830	COG0535	radical SAM domain protein
ZHX2020_08840	COG1131	(ABC) transporter
ZHX2020_08845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ZHX2020_08850	COG0612	Peptidase, M16
ZHX2020_08855	COG0612	Peptidase, M16
ZHX2020_08865	COG3391	amine dehydrogenase activity
ZHX2020_08870	COG3391	amine dehydrogenase activity
ZHX2020_08875	COG0457	Tetratricopeptide repeat
ZHX2020_08885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZHX2020_08890	COG0010	Belongs to the arginase family
ZHX2020_08895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ZHX2020_08900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZHX2020_08915	COG1994	Peptidase M50
ZHX2020_08920	COG1942	4-Oxalocrotonate Tautomerase
ZHX2020_08925	COG1846	Transcriptional regulator
ZHX2020_08930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZHX2020_08935	COG0477	Major facilitator Superfamily
ZHX2020_08940	COG1959	2 iron, 2 sulfur cluster binding
ZHX2020_08945	COG3465	dGTPase activity
ZHX2020_08950	COG1078	dGTPase activity
ZHX2020_08955	COG4844	belongs to the
ZHX2020_08965	COG0697	spore germination
ZHX2020_08970	COG0095	Lipoate-protein ligase
ZHX2020_08975	COG0583	DNA-binding transcription factor activity
ZHX2020_08980	COG0280	phosphate acetyltransferase
ZHX2020_08985	COG3253	May function as heme-dependent peroxidase
ZHX2020_08990	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_08995	COG0436	Aminotransferase
ZHX2020_09000	COG2814	Major facilitator Superfamily
ZHX2020_09005	COG0151	Belongs to the GarS family
ZHX2020_09010	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_09015	COG1917	Cupin 2, conserved barrel domain protein
ZHX2020_09020	COG0077	Prephenate dehydratase
ZHX2020_09025	COG2814	Major facilitator Superfamily
ZHX2020_09030	COG0833	amino acid
ZHX2020_09035	COG4187	Peptidase family M20/M25/M40
ZHX2020_09040	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_09045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZHX2020_09055	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ZHX2020_09060	COG1091	dTDP-4-dehydrorhamnose reductase activity
ZHX2020_09065	COG1088	dTDP-glucose 4,6-dehydratase activity
ZHX2020_09070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ZHX2020_09075	COG3980	spore coat polysaccharide biosynthesis protein
ZHX2020_09080	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ZHX2020_09085	COG2089	acid synthase
ZHX2020_09090	COG0456	acetyltransferase
ZHX2020_09095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ZHX2020_09100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ZHX2020_09105	COG0463	Glycosyl transferase, family 2
ZHX2020_09115	COG2363	Small membrane protein
ZHX2020_09120	COG2233	PERMEase
ZHX2020_09130	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_09135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ZHX2020_09140	COG1216	Glycosyl transferase, family 2
ZHX2020_09145	COG0351	phosphomethylpyrimidine kinase
ZHX2020_09155	COG1621	beta-fructofuranosidase activity
ZHX2020_09160	COG1263	PTS System
ZHX2020_09160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_09165	COG2116	formate transmembrane transporter activity
ZHX2020_09180	COG1404	Belongs to the peptidase S8 family
ZHX2020_09185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZHX2020_09190	COG0778	Nitroreductase
ZHX2020_09195	COG0772	Belongs to the SEDS family
ZHX2020_09210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ZHX2020_09215	COG1845	cytochrome c oxidase, subunit III
ZHX2020_09220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ZHX2020_09225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ZHX2020_09230	COG2261	transglycosylase associated protein
ZHX2020_09235	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ZHX2020_09240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ZHX2020_09245	COG2246	polysaccharide biosynthetic process
ZHX2020_09250	COG1309	transcriptional regulator
ZHX2020_09260	COG3162	membrane
ZHX2020_09265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ZHX2020_09270	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ZHX2020_09275	COG2837	iron assimilation
ZHX2020_09280	COG2822	iron ion transport
ZHX2020_09285	COG0672	)-iron permease
ZHX2020_09290	COG0352	thiamine-phosphate diphosphorylase activity
ZHX2020_09295	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ZHX2020_09300	COG0583	DNA-binding transcription factor activity
ZHX2020_09305	COG1380	Effector of murein hydrolase LrgA
ZHX2020_09310	COG1346	cytolysis
ZHX2020_09315	COG2814	Major facilitator Superfamily
ZHX2020_09320	COG4895	conserved protein (DUF2196)
ZHX2020_09325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ZHX2020_09330	COG0346	lactoylglutathione lyase activity
ZHX2020_09340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZHX2020_09350	COG1263	PTS System
ZHX2020_09350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_09355	COG3711	transcriptional antiterminator
ZHX2020_09360	COG1442	glycosyl transferase family 8
ZHX2020_09365	COG5522	Integral membrane protein (intg_mem_TP0381)
ZHX2020_09370	COG1846	Transcriptional regulator
ZHX2020_09375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZHX2020_09380	COG2234	aminopeptidase activity
ZHX2020_09385	COG2357	RelA SpoT domain protein
ZHX2020_09395	COG1575	Belongs to the MenA family. Type 1 subfamily
ZHX2020_09410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZHX2020_09415	COG1696	Membrane protein involved in D-alanine export
ZHX2020_09420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZHX2020_09425	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ZHX2020_09435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZHX2020_09440	COG1486	melibiose metabolic process
ZHX2020_09445	COG1447	Phosphotransferase system cellobiose-specific component IIA
ZHX2020_09450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZHX2020_09455	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZHX2020_09460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_09460	COG3711	transcriptional antiterminator
ZHX2020_09470	COG2094	Belongs to the DNA glycosylase MPG family
ZHX2020_09475	COG0753	catalase activity
ZHX2020_09480	COG2814	Major facilitator Superfamily
ZHX2020_09485	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ZHX2020_09490	COG1131	(ABC) transporter
ZHX2020_09510	COG1595	DNA-templated transcription, initiation
ZHX2020_09515	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ZHX2020_09520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ZHX2020_09525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ZHX2020_09530	COG4988	ABC transporter
ZHX2020_09535	COG1294	oxidase, subunit
ZHX2020_09540	COG1271	oxidase subunit
ZHX2020_09545	COG3493	citrate carrier protein
ZHX2020_09550	COG0501	Belongs to the peptidase M48B family
ZHX2020_09560	COG0726	polysaccharide deacetylase
ZHX2020_09565	COG3842	ATPase activity
ZHX2020_09570	COG2508	Transcriptional regulator
ZHX2020_09575	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_09580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZHX2020_09585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ZHX2020_09595	COG4585	Histidine kinase
ZHX2020_09600	COG2197	response regulator
ZHX2020_09605	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZHX2020_09615	COG4894	glucomannan catabolic process
ZHX2020_09620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZHX2020_09625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZHX2020_09630	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_09635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ZHX2020_09640	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ZHX2020_09645	COG2610	gluconate transmembrane transporter activity
ZHX2020_09650	COG0500	methyltransferase
ZHX2020_09655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZHX2020_09670	COG0693	protein deglycase activity
ZHX2020_09670	COG0753	catalase activity
ZHX2020_09675	COG2851	Citrate transporter
ZHX2020_09680	COG2273	Hydrolase Family 16
ZHX2020_09685	COG3711	transcriptional antiterminator
ZHX2020_09695	COG2270	Major facilitator Superfamily
ZHX2020_09700	COG0513	Belongs to the DEAD box helicase family
ZHX2020_09705	COG2755	lipolytic protein G-D-S-L family
ZHX2020_09705	COG3401	FG-GAP repeat protein
ZHX2020_09830	COG0589	response to stress
ZHX2020_09840	COG1263	PTS System
ZHX2020_09840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_09840	COG2190	(PTS) system
ZHX2020_09860	COG5444	nuclease activity
ZHX2020_09880	COG0494	nUDIX hydrolase
ZHX2020_09885	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ZHX2020_09890	COG3507	Belongs to the glycosyl hydrolase 43 family
ZHX2020_09905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ZHX2020_09910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZHX2020_09915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ZHX2020_09920	COG2390	Transcriptional regulator
ZHX2020_09930	COG3192	ethanolamine utilization protein
ZHX2020_09935	COG2079	MmgE PrpD family protein
ZHX2020_09940	COG1473	amidohydrolase
ZHX2020_09945	COG1126	abc transporter atp-binding protein
ZHX2020_09950	COG0765	amino acid transport
ZHX2020_09955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZHX2020_09960	COG0456	acetyltransferase
ZHX2020_09965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZHX2020_09970	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ZHX2020_09975	COG0561	phosphatase activity
ZHX2020_10005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZHX2020_10010	COG5294	Protein conserved in bacteria
ZHX2020_10025	COG2205	protein histidine kinase activity
ZHX2020_10030	COG0745	RESPONSE REGULATOR receiver
ZHX2020_10035	COG0191	fructose-bisphosphate aldolase activity
ZHX2020_10040	COG1082	Xylose isomerase domain protein TIM barrel
ZHX2020_10045	COG1082	Xylose isomerase domain protein TIM barrel
ZHX2020_10050	COG0673	inositol 2-dehydrogenase activity
ZHX2020_10055	COG2814	Major facilitator Superfamily
ZHX2020_10060	COG1082	Xylose isomerase domain protein TIM barrel
ZHX2020_10065	COG3962	Belongs to the TPP enzyme family
ZHX2020_10070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZHX2020_10090	COG1349	DNA-binding transcription factor activity
ZHX2020_10095	COG0667	Aldo Keto reductase
ZHX2020_10125	COG0326	Molecular chaperone. Has ATPase activity
ZHX2020_10180	COG1917	Cupin 2, conserved barrel domain protein
ZHX2020_10185	COG1309	transcriptional regulator
ZHX2020_10190	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_10195	COG1846	Transcriptional regulator
ZHX2020_10200	COG1380	Effector of murein hydrolase LrgA
ZHX2020_10205	COG1346	cytolysis
ZHX2020_10210	COG5039	Polysaccharide pyruvyl transferase
ZHX2020_10215	COG1929	Belongs to the glycerate kinase type-1 family
ZHX2020_10220	COG1802	Transcriptional regulator
ZHX2020_10225	COG1070	Carbohydrate kinase
ZHX2020_10230	COG2610	gluconate transmembrane transporter activity
ZHX2020_10235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ZHX2020_10240	COG0450	alkyl hydroperoxide reductase
ZHX2020_10245	COG3634	alkyl hydroperoxide reductase activity
ZHX2020_10250	COG2723	6-phospho-beta-galactosidase activity
ZHX2020_10260	COG2188	Transcriptional regulator
ZHX2020_10270	COG1131	(ABC) transporter
ZHX2020_10275	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ZHX2020_10290	COG0071	Belongs to the small heat shock protein (HSP20) family
ZHX2020_10320	COG0210	DNA helicase
ZHX2020_10350	COG2963	transposase activity
ZHX2020_10385	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZHX2020_10400	COG1063	alcohol dehydrogenase
ZHX2020_10420	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ZHX2020_10425	COG0456	acetyltransferase
ZHX2020_10430	COG0457	Tetratricopeptide repeat
ZHX2020_10440	COG0010	Belongs to the arginase family
ZHX2020_10445	COG0833	amino acid
ZHX2020_10450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZHX2020_10470	COG5658	integral membrane protein
ZHX2020_10475	COG0640	Transcriptional regulator
ZHX2020_10480	COG3829	transcription factor binding
ZHX2020_10495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZHX2020_10500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ZHX2020_10505	COG4853	Protein conserved in bacteria
ZHX2020_10510	COG4863	YycH protein
ZHX2020_10515	COG5002	protein histidine kinase activity
ZHX2020_10520	COG0745	RESPONSE REGULATOR receiver
ZHX2020_10550	COG0346	lactoylglutathione lyase activity
ZHX2020_10555	COG0305	Participates in initiation and elongation during chromosome replication
ZHX2020_10570	COG3093	addiction module antidote protein HigA
ZHX2020_10575	COG2807	transmembrane transport
ZHX2020_10580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ZHX2020_10585	COG0359	binds to the 23S rRNA
ZHX2020_10590	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ZHX2020_10595	COG4241	membrane
ZHX2020_10610	COG1733	regulation of RNA biosynthetic process
ZHX2020_10615	COG1227	inorganic diphosphatase activity
ZHX2020_10630	COG2271	Major facilitator Superfamily
ZHX2020_10635	COG0789	Transcriptional regulator
ZHX2020_10635	COG4978	Transcriptional regulator
ZHX2020_10645	COG4319	ketosteroid isomerase
ZHX2020_10650	COG1357	PFAM Pentapeptide repeats (8 copies)
ZHX2020_10665	COG1846	Transcriptional regulator
ZHX2020_10670	COG2153	protein acetylation
ZHX2020_10675	COG2364	Membrane
ZHX2020_10680	COG0456	acetyltransferase
ZHX2020_10685	COG2315	Protein conserved in bacteria
ZHX2020_10690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZHX2020_10695	COG1331	Highly conserved protein containing a thioredoxin domain
ZHX2020_10700	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ZHX2020_10705	COG1331	Highly conserved protein containing a thioredoxin domain
ZHX2020_10710	COG1266	CAAX protease self-immunity
ZHX2020_10715	COG2814	Major facilitator Superfamily
ZHX2020_10715	COG0477	Major facilitator Superfamily
ZHX2020_10720	COG0346	lactoylglutathione lyase activity
ZHX2020_10725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZHX2020_10730	COG0542	response to heat
ZHX2020_10745	COG0708	Exodeoxyribonuclease III
ZHX2020_10750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZHX2020_10755	COG0629	single-stranded DNA binding
ZHX2020_10760	COG0360	Binds together with S18 to 16S ribosomal RNA
ZHX2020_10765	COG0012	GTP binding
ZHX2020_10770	COG0243	molybdopterin cofactor binding
ZHX2020_10775	COG4481	Protein conserved in bacteria
ZHX2020_10780	COG3949	Membrane
ZHX2020_10790	COG1475	DNA binding
ZHX2020_10795	COG1192	Involved in chromosome partitioning
ZHX2020_10805	COG1475	DNA binding
ZHX2020_10810	COG0357	Ribosomal RNA small subunit methyltransferase G
ZHX2020_10815	COG0445	tRNA wobble uridine modification
ZHX2020_10820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZHX2020_10825	COG1847	R3H domain protein
ZHX2020_10830	COG0706	membrane insertase activity
ZHX2020_10835	COG0594	ribonuclease P activity
ZHX2020_10845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZHX2020_10850	COG0592	DNA-directed DNA polymerase activity
ZHX2020_10855	COG2501	S4 domain
ZHX2020_10860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZHX2020_10870	COG0187	DNA topoisomerase II activity
ZHX2020_10875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZHX2020_10910	COG0517	IMP dehydrogenase activity
ZHX2020_10910	COG0516	GMP reductase activity
ZHX2020_10915	COG1686	Belongs to the peptidase S11 family
ZHX2020_10920	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ZHX2020_10925	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ZHX2020_10930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZHX2020_10940	COG1428	Deoxynucleoside kinase
ZHX2020_10945	COG1428	Deoxynucleoside kinase
ZHX2020_10950	COG1388	LysM domain
ZHX2020_10950	COG3858	chitin binding
ZHX2020_10955	COG1335	isochorismatase
ZHX2020_10960	COG0590	tRNA wobble adenosine to inosine editing
ZHX2020_10970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZHX2020_10975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZHX2020_10980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZHX2020_11025	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ZHX2020_11030	COG3853	Toxic anion resistance protein (TelA)
ZHX2020_11035	COG1982	Orn Lys Arg decarboxylase major
ZHX2020_11040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZHX2020_11045	COG3870	Protein conserved in bacteria
ZHX2020_11050	COG1728	Protein conserved in bacteria
ZHX2020_11055	COG0470	DNA polymerase III
ZHX2020_11060	COG1774	PSP1 C-terminal conserved region
ZHX2020_11065	COG4467	Involved in initiation control of chromosome replication
ZHX2020_11070	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ZHX2020_11075	COG2827	Endonuclease containing a URI domain
ZHX2020_11080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZHX2020_11085	COG2002	toxin-antitoxin pair type II binding
ZHX2020_11090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZHX2020_11090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZHX2020_11095	COG0084	hydrolase, TatD family'
ZHX2020_11100	COG3583	domain protein
ZHX2020_11100	COG3584	3D domain protein
ZHX2020_11105	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ZHX2020_11110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZHX2020_11120	COG4466	Protein conserved in bacteria
ZHX2020_11130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ZHX2020_11135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ZHX2020_11140	COG0251	oxidation-reduction process
ZHX2020_11145	COG2088	sporulation resulting in formation of a cellular spore
ZHX2020_11150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZHX2020_11155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZHX2020_11160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZHX2020_11165	COG0193	aminoacyl-tRNA hydrolase activity
ZHX2020_11175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZHX2020_11180	COG2002	toxin-antitoxin pair type II binding
ZHX2020_11185	COG2244	polysaccharide biosynthetic process
ZHX2020_11190	COG3956	TIGRFAM MazG family protein
ZHX2020_11195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ZHX2020_11210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ZHX2020_11215	COG1098	S1 RNA binding domain
ZHX2020_11230	COG2208	phosphoserine phosphatase activity
ZHX2020_11235	COG2304	oxidoreductase activity
ZHX2020_11240	COG0515	serine threonine protein kinase
ZHX2020_11245	COG0037	tRNA processing
ZHX2020_11250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ZHX2020_11255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZHX2020_11260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZHX2020_11265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ZHX2020_11270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZHX2020_11275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ZHX2020_11280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZHX2020_11285	COG0512	Glutamine amidotransferase of anthranilate synthase
ZHX2020_11290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZHX2020_11295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZHX2020_11300	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ZHX2020_11305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ZHX2020_11310	COG1396	sequence-specific DNA binding
ZHX2020_11315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ZHX2020_11320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ZHX2020_11400	COG4463	regulation of RNA biosynthetic process
ZHX2020_11405	COG3880	PFAM UvrB UvrC protein
ZHX2020_11410	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ZHX2020_11415	COG0542	response to heat
ZHX2020_11420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ZHX2020_11425	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ZHX2020_11430	COG4956	integral membrane protein (PIN domain superfamily)
ZHX2020_11435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ZHX2020_11440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ZHX2020_11445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZHX2020_11450	COG1045	serine acetyltransferase
ZHX2020_11455	COG0215	cysteine-tRNA ligase activity
ZHX2020_11460	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ZHX2020_11465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZHX2020_11470	COG3688	RNA-binding protein containing a PIN domain
ZHX2020_11475	COG1595	DNA-templated transcription, initiation
ZHX2020_11485	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ZHX2020_11490	COG0250	Participates in transcription elongation, termination and antitermination
ZHX2020_11500	COG0081	regulation of translation
ZHX2020_11505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZHX2020_11515	COG2813	Specifically methylates the guanine in position
ZHX2020_11520	COG0085	RNA polymerase activity
ZHX2020_11525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZHX2020_11530	COG1358	cellular component organization or biogenesis
ZHX2020_11535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZHX2020_11540	COG0049	tRNA binding
ZHX2020_11545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZHX2020_11550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZHX2020_11555	COG0596	Alpha beta hydrolase
ZHX2020_11565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZHX2020_11570	COG0088	Forms part of the polypeptide exit tunnel
ZHX2020_11580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZHX2020_11595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZHX2020_11600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZHX2020_11610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZHX2020_11615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZHX2020_11625	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZHX2020_11635	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZHX2020_11640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZHX2020_11645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZHX2020_11650	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZHX2020_11660	COG0200	Binds to the 23S rRNA
ZHX2020_11665	COG0201	protein transport
ZHX2020_11670	COG0563	adenylate kinase activity
ZHX2020_11675	COG0024	Methionine aminopeptidase
ZHX2020_11690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZHX2020_11695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZHX2020_11700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZHX2020_11705	COG0202	RNA polymerase activity
ZHX2020_11710	COG0203	ribosomal protein L17
ZHX2020_11715	COG1122	ATPase activity
ZHX2020_11720	COG1122	ATPase activity
ZHX2020_11725	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ZHX2020_11730	COG0101	tRNA pseudouridine synthase activity
ZHX2020_11735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZHX2020_11740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZHX2020_11745	COG2226	methyltransferase
ZHX2020_11755	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_11760	COG0489	protein tyrosine kinase activity
ZHX2020_11770	COG2194	sulfuric ester hydrolase activity
ZHX2020_11775	COG0726	polysaccharide deacetylase
ZHX2020_11855	COG0659	secondary active sulfate transmembrane transporter activity
ZHX2020_11860	COG0385	Bile acid
ZHX2020_11865	COG2819	hydrolase of the alpha beta superfamily
ZHX2020_11870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_11875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_11880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZHX2020_11885	COG2207	Transcriptional regulator
ZHX2020_11885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZHX2020_11890	COG3876	Protein conserved in bacteria
ZHX2020_11895	COG1472	Belongs to the glycosyl hydrolase 3 family
ZHX2020_11900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZHX2020_11905	COG1263	PTS System
ZHX2020_11905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_11910	COG1737	Transcriptional regulator
ZHX2020_11915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ZHX2020_11920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_11925	COG1683	Conserved Protein
ZHX2020_11955	COG1595	DNA-templated transcription, initiation
ZHX2020_11960	COG5662	AntiSigma factor
ZHX2020_11965	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ZHX2020_11970	COG4856	YbbR-like protein
ZHX2020_11975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZHX2020_11980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZHX2020_11995	COG2169	Transcriptional regulator
ZHX2020_12000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZHX2020_12005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ZHX2020_12010	COG3002	Belongs to the UPF0753 family
ZHX2020_12015	COG0288	reversible hydration of carbon dioxide
ZHX2020_12025	COG5609	conserved protein (DUF2294)
ZHX2020_12035	COG0642	Histidine kinase
ZHX2020_12045	COG0515	serine threonine protein kinase
ZHX2020_12060	COG1113	amino acid transport
ZHX2020_12075	COG2602	Beta-lactamase
ZHX2020_12080	COG2124	cytochrome p450
ZHX2020_12090	COG0531	amino acid
ZHX2020_12095	COG0584	glycerophosphoryl diester phosphodiesterase
ZHX2020_12100	COG2271	Major facilitator Superfamily
ZHX2020_12110	COG0456	acetyltransferase
ZHX2020_12110	COG1846	Transcriptional regulator
ZHX2020_12125	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_12130	COG0697	spore germination
ZHX2020_12135	COG1917	Cupin 2, conserved barrel domain protein
ZHX2020_12135	COG2207	Transcriptional regulator
ZHX2020_12160	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ZHX2020_12165	COG3591	Belongs to the peptidase S1B family
ZHX2020_12175	COG0596	Alpha beta hydrolase
ZHX2020_12180	COG1183	phosphatidylcholine synthase activity
ZHX2020_12185	COG0586	Pfam SNARE associated Golgi protein
ZHX2020_12190	COG0688	phosphatidylethanolamine metabolic process
ZHX2020_12200	COG2312	Erythromycin esterase
ZHX2020_12205	COG2207	Transcriptional regulator
ZHX2020_12210	COG1054	Belongs to the UPF0176 family
ZHX2020_12215	COG1301	dicarboxylic acid transport
ZHX2020_12220	COG1263	PTS System
ZHX2020_12220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_12220	COG2190	(PTS) system
ZHX2020_12225	COG0363	glucosamine-6-phosphate deaminase activity
ZHX2020_12230	COG2188	Transcriptional regulator
ZHX2020_12240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZHX2020_12245	COG0833	amino acid
ZHX2020_12250	COG2040	homocysteine
ZHX2020_12260	COG2066	Belongs to the glutaminase family
ZHX2020_12265	COG4191	Histidine kinase
ZHX2020_12270	COG0784	Response regulator, receiver
ZHX2020_12275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZHX2020_12280	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_12285	COG2271	Major facilitator Superfamily
ZHX2020_12290	COG4948	Mandelate Racemase Muconate Lactonizing
ZHX2020_12295	COG2186	Transcriptional regulator
ZHX2020_12300	COG2721	sulfolactate sulfo-lyase activity
ZHX2020_12305	COG3173	Aminoglycoside phosphotransferase
ZHX2020_12315	COG0697	spore germination
ZHX2020_12320	COG0745	RESPONSE REGULATOR receiver
ZHX2020_12325	COG2205	protein histidine kinase activity
ZHX2020_12330	COG1131	(ABC) transporter
ZHX2020_12350	COG3773	Cell wall hydrolase
ZHX2020_12355	COG2304	oxidoreductase activity
ZHX2020_12365	COG3540	Alkaline phosphatase
ZHX2020_12370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZHX2020_12375	COG0805	protein transport
ZHX2020_12380	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ZHX2020_12385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZHX2020_12390	COG0477	Major facilitator Superfamily
ZHX2020_12395	COG1309	transcriptional regulator
ZHX2020_12400	COG0252	asparaginase activity
ZHX2020_12405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ZHX2020_12410	COG1714	RDD family
ZHX2020_12415	COG1405	negative regulation of cell septum assembly
ZHX2020_12415	COG3012	SEC-C Motif Domain Protein
ZHX2020_12425	COG3279	Response regulator of the LytR AlgR family
ZHX2020_12435	COG1668	transmembrane transport
ZHX2020_12440	COG0667	Aldo Keto reductase
ZHX2020_12455	COG1595	DNA-templated transcription, initiation
ZHX2020_12460	COG1595	DNA-templated transcription, initiation
ZHX2020_12465	COG1876	peptidase activity
ZHX2020_12475	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_12480	COG0366	Alpha amylase catalytic
ZHX2020_12485	COG0803	Belongs to the bacterial solute-binding protein 9 family
ZHX2020_12490	COG1121	(ABC) transporter
ZHX2020_12495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZHX2020_12505	COG2310	stress, protein
ZHX2020_12510	COG2310	stress, protein
ZHX2020_12515	COG2310	stress, protein
ZHX2020_12520	COG0861	Integral membrane protein TerC family
ZHX2020_12530	COG3853	Toxic anion resistance protein (TelA)
ZHX2020_12540	COG0477	Major facilitator Superfamily
ZHX2020_12545	COG2814	Major facilitator Superfamily
ZHX2020_12550	COG0640	Transcriptional regulator
ZHX2020_12555	COG0517	IMP dehydrogenase activity
ZHX2020_12555	COG4175	Glycine betaine
ZHX2020_12560	COG4176	ABC-type proline glycine betaine transport system permease component
ZHX2020_12565	COG2113	Glycine betaine
ZHX2020_12570	COG1473	amidohydrolase
ZHX2020_12575	COG1288	antiporter activity
ZHX2020_12590	COG0039	L-malate dehydrogenase activity
ZHX2020_12605	COG3403	YqcI/YcgG family
ZHX2020_12620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ZHX2020_12625	COG1660	Displays ATPase and GTPase activities
ZHX2020_12630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZHX2020_12640	COG2226	methyltransferase
ZHX2020_12645	COG0583	DNA-binding transcription factor activity
ZHX2020_12650	COG3458	cephalosporin-C deacetylase activity
ZHX2020_12655	COG3541	Predicted nucleotidyltransferase
ZHX2020_12660	COG0506	proline dehydrogenase activity
ZHX2020_12665	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_12670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ZHX2020_12675	COG2508	Transcriptional regulator
ZHX2020_12680	COG3689	TIGRFAM TIGR03943 family protein
ZHX2020_12685	COG0701	Predicted permease
ZHX2020_12690	COG2267	carboxylic ester hydrolase activity
ZHX2020_12695	COG0492	ferredoxin-NADP+ reductase activity
ZHX2020_12700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZHX2020_12700	COG1587	Uroporphyrinogen-III synthase
ZHX2020_12705	COG2146	nitrite reductase [NAD(P)H] activity
ZHX2020_12710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZHX2020_12715	COG0243	molybdopterin cofactor binding
ZHX2020_12720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZHX2020_12725	COG2223	nitrite transmembrane transporter activity
ZHX2020_12735	COG1376	ErfK ybiS ycfS ynhG family protein
ZHX2020_12750	COG0765	amino acid transport
ZHX2020_12755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZHX2020_12765	COG1714	RDD family
ZHX2020_12775	COG1846	Transcriptional regulator
ZHX2020_12790	COG2723	6-phospho-beta-galactosidase activity
ZHX2020_12800	COG3209	COG3209 Rhs family protein
ZHX2020_12810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZHX2020_12815	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ZHX2020_12820	COG1733	regulation of RNA biosynthetic process
ZHX2020_12825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZHX2020_12830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZHX2020_12835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZHX2020_12840	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ZHX2020_12845	COG2814	Major facilitator Superfamily
ZHX2020_12855	COG0697	spore germination
ZHX2020_12860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZHX2020_12870	COG2364	Membrane
ZHX2020_12875	COG1126	abc transporter atp-binding protein
ZHX2020_12880	COG0765	amino acid transport
ZHX2020_12885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZHX2020_12890	COG0583	DNA-binding transcription factor activity
ZHX2020_12895	COG0163	prenyltransferase activity
ZHX2020_12900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ZHX2020_12915	COG0596	Alpha beta hydrolase
ZHX2020_12920	COG3104	oligopeptide transport
ZHX2020_12925	COG5434	Belongs to the glycosyl hydrolase 28 family
ZHX2020_12935	COG0697	spore germination
ZHX2020_12945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ZHX2020_12950	COG1136	(ABC) transporter
ZHX2020_12955	COG0577	efflux transmembrane transporter activity
ZHX2020_12960	COG0745	RESPONSE REGULATOR receiver
ZHX2020_12965	COG3850	Histidine kinase
ZHX2020_12965	COG5002	protein histidine kinase activity
ZHX2020_12970	COG0457	Tetratricopeptide repeat
ZHX2020_12990	COG0527	aspartate kinase activity
ZHX2020_12995	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_13000	COG4605	iron ion homeostasis
ZHX2020_13005	COG4604	ABC transporter, ATP-binding protein
ZHX2020_13010	COG4607	ABC-type enterochelin transport system periplasmic component
ZHX2020_13020	COG2814	Major facilitator Superfamily
ZHX2020_13025	COG1309	transcriptional regulator
ZHX2020_13030	COG0778	Nitroreductase
ZHX2020_13035	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ZHX2020_13040	COG0640	Transcriptional regulator
ZHX2020_13045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZHX2020_13050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ZHX2020_13055	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_13060	COG4975	Glucose uptake
ZHX2020_13065	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_13070	COG4549	nuclear export factor GLE1
ZHX2020_13075	COG1276	copper resistance
ZHX2020_13075	COG2372	response to copper ion
ZHX2020_13080	COG1349	DNA-binding transcription factor activity
ZHX2020_13090	COG2213	PTS system mannitol-specific
ZHX2020_13095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_13100	COG0246	Mannitol dehydrogenase
ZHX2020_13105	COG0473	3-isopropylmalate dehydrogenase activity
ZHX2020_13110	COG0681	Belongs to the peptidase S26 family
ZHX2020_13120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZHX2020_13130	COG0561	phosphatase activity
ZHX2020_13135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ZHX2020_13140	COG1914	H( )-stimulated, divalent metal cation uptake system
ZHX2020_13145	COG4336	lyase activity
ZHX2020_13150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ZHX2020_13155	COG1984	allophanate hydrolase subunit 2
ZHX2020_13160	COG1414	Transcriptional regulator
ZHX2020_13165	COG2755	lipolytic protein G-D-S-L family
ZHX2020_13175	COG2329	Antibiotic biosynthesis monooxygenase
ZHX2020_13180	COG0768	penicillin binding
ZHX2020_13185	COG4989	oxidoreductase activity
ZHX2020_13190	COG3711	transcriptional antiterminator
ZHX2020_13195	COG0318	PFAM AMP-dependent synthetase and ligase
ZHX2020_13200	COG2226	methyltransferase
ZHX2020_13205	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_13210	COG1917	Cupin 2, conserved barrel domain protein
ZHX2020_13215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_13220	COG3871	stress protein (general stress protein 26)
ZHX2020_13230	COG2814	Major facilitator Superfamily
ZHX2020_13235	COG1522	sequence-specific DNA binding
ZHX2020_13240	COG0551	DNA topoisomerase type I activity
ZHX2020_13240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZHX2020_13245	COG0494	nUDIX hydrolase
ZHX2020_13250	COG0028	Belongs to the TPP enzyme family
ZHX2020_13275	COG1914	H( )-stimulated, divalent metal cation uptake system
ZHX2020_13280	COG2261	transglycosylase associated protein
ZHX2020_13285	COG4876	unkown
ZHX2020_13290	COG2217	Heavy metal translocating P-type atpase
ZHX2020_13295	COG3729	General stress protein
ZHX2020_13300	COG0662	Cupin 2, conserved barrel domain protein
ZHX2020_13305	COG2329	Antibiotic biosynthesis monooxygenase
ZHX2020_13310	COG3546	catalase activity
ZHX2020_13315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ZHX2020_13320	COG3290	protein histidine kinase activity
ZHX2020_13325	COG4565	transcriptional regulatory protein
ZHX2020_13330	COG1301	dicarboxylic acid transport
ZHX2020_13335	COG0628	permease
ZHX2020_13345	COG1131	(ABC) transporter
ZHX2020_13350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ZHX2020_13360	COG1960	acyl-CoA dehydrogenase activity
ZHX2020_13375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ZHX2020_13380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_13385	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZHX2020_13390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ZHX2020_13395	COG0513	Belongs to the DEAD box helicase family
ZHX2020_13400	COG3402	PFAM membrane-flanked domain
ZHX2020_13405	COG3428	Bacterial PH domain
ZHX2020_13410	COG0705	Rhomboid family
ZHX2020_13415	COG0736	holo-[acyl-carrier-protein] synthase activity
ZHX2020_13420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ZHX2020_13425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZHX2020_13430	COG0864	Transcriptional regulator
ZHX2020_13435	COG2337	Toxic component of a toxin-antitoxin (TA) module
ZHX2020_13440	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_13445	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_13450	COG2172	sigma factor antagonist activity
ZHX2020_13455	COG2208	phosphoserine phosphatase activity
ZHX2020_13460	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_13465	COG2172	sigma factor antagonist activity
ZHX2020_13470	COG1191	sigma factor activity
ZHX2020_13475	COG2208	phosphoserine phosphatase activity
ZHX2020_13490	COG1673	EVE domain
ZHX2020_13495	COG1846	Transcriptional regulator
ZHX2020_13500	COG2183	response to ionizing radiation
ZHX2020_13510	COG3091	SprT-like family
ZHX2020_13550	COG0582	viral genome integration into host DNA
ZHX2020_13555	COG2856	Zn peptidase
ZHX2020_13560	COG1396	sequence-specific DNA binding
ZHX2020_13590	COG1674	ftsk spoiiie
ZHX2020_13595	COG2946	Replication initiation factor
ZHX2020_13635	COG0433	COG0433 Predicted ATPase
ZHX2020_13645	COG5644	endopeptidase inhibitor activity
ZHX2020_13655	COG0741	lytic transglycosylase activity
ZHX2020_13655	COG0791	NLP P60 protein
ZHX2020_13670	COG0457	Tetratricopeptide repeat
ZHX2020_13700	COG0583	DNA-binding transcription factor activity
ZHX2020_13705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_13715	COG5444	nuclease activity
ZHX2020_13720	COG1476	TRANSCRIPTIONal
ZHX2020_13740	COG0693	protein deglycase activity
ZHX2020_13745	COG1278	Cold shock
ZHX2020_13750	COG1329	Transcriptional regulator
ZHX2020_13755	COG0697	spore germination
ZHX2020_13760	COG1917	Cupin 2, conserved barrel domain protein
ZHX2020_13760	COG2207	Transcriptional regulator
ZHX2020_13770	COG2207	Transcriptional regulator
ZHX2020_13770	COG3708	Transcriptional regulator
ZHX2020_13775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZHX2020_13790	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ZHX2020_13805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_13810	COG1309	transcriptional regulator
ZHX2020_13815	COG0697	spore germination
ZHX2020_13820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZHX2020_13825	COG2030	dehydratase
ZHX2020_13830	COG3545	Serine hydrolase
ZHX2020_13840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZHX2020_13845	COG0640	Transcriptional regulator
ZHX2020_13850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ZHX2020_13860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_13865	COG0697	spore germination
ZHX2020_13870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZHX2020_13875	COG0076	glutamate decarboxylase activity
ZHX2020_13880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ZHX2020_13885	COG0640	Transcriptional regulator
ZHX2020_13890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ZHX2020_13905	COG4585	Histidine kinase
ZHX2020_13910	COG2197	response regulator
ZHX2020_13915	COG2409	Drug exporters of the RND superfamily
ZHX2020_13920	COG0596	Alpha beta hydrolase
ZHX2020_13925	COG1811	Na channel or pump
ZHX2020_13930	COG0789	Transcriptional regulator
ZHX2020_13930	COG4978	Transcriptional regulator
ZHX2020_13935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ZHX2020_13940	COG0778	Nitroreductase
ZHX2020_13945	COG0346	lactoylglutathione lyase activity
ZHX2020_13950	COG2259	Doxx family
ZHX2020_13955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_13980	COG2323	membrane
ZHX2020_13985	COG0071	Belongs to the small heat shock protein (HSP20) family
ZHX2020_14000	COG1309	transcriptional regulator
ZHX2020_14010	COG0456	acetyltransferase
ZHX2020_14015	COG0488	(ABC) transporter
ZHX2020_14020	COG1113	amino acid transport
ZHX2020_14025	COG2318	DinB family
ZHX2020_14030	COG1846	Transcriptional regulator
ZHX2020_14035	COG2409	Drug exporters of the RND superfamily
ZHX2020_14035	COG1033	growth of symbiont in host cell
ZHX2020_14040	COG0778	Nitroreductase
ZHX2020_14045	COG1846	Transcriptional regulator
ZHX2020_14050	COG2814	Major facilitator Superfamily
ZHX2020_14055	COG0730	response to heat
ZHX2020_14060	COG1802	Transcriptional regulator
ZHX2020_14065	COG1388	LysM domain
ZHX2020_14065	COG3858	chitin binding
ZHX2020_14070	COG1819	glycosyl
ZHX2020_14080	COG1785	Belongs to the alkaline phosphatase family
ZHX2020_14085	COG5646	InterPro IPR014922
ZHX2020_14095	COG0454	-acetyltransferase
ZHX2020_14100	COG1078	dGTPase activity
ZHX2020_14105	COG1388	LysM domain
ZHX2020_14110	COG2814	Major facilitator Superfamily
ZHX2020_14115	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ZHX2020_14130	COG2723	6-phospho-beta-galactosidase activity
ZHX2020_14135	COG2188	Transcriptional regulator
ZHX2020_14140	COG1940	carbohydrate kinase activity
ZHX2020_14150	COG4124	Belongs to the glycosyl hydrolase 26 family
ZHX2020_14195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZHX2020_14200	COG0802	atpase or kinase
ZHX2020_14205	COG1214	PFAM Peptidase M22, glycoprotease
ZHX2020_14210	COG0456	acetyltransferase
ZHX2020_14215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZHX2020_14220	COG0488	(ABC) transporter
ZHX2020_14225	COG0315	cyclic pyranopterin monophosphate synthase activity
ZHX2020_14230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ZHX2020_14235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZHX2020_14240	COG0805	protein transport
ZHX2020_14250	COG1266	CAAX protease self-immunity
ZHX2020_14260	COG0459	protein refolding
ZHX2020_14280	COG0457	Tetratricopeptide repeat
ZHX2020_14285	COG1063	alcohol dehydrogenase
ZHX2020_14290	COG2211	Major facilitator Superfamily
ZHX2020_14295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZHX2020_14305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ZHX2020_14310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ZHX2020_14315	COG4260	virion core protein, lumpy skin disease virus
ZHX2020_14325	COG2814	Major facilitator Superfamily
ZHX2020_14330	COG1063	alcohol dehydrogenase
ZHX2020_14335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ZHX2020_14340	COG0823	Involved in the tonB-independent uptake of proteins
ZHX2020_14360	COG2267	carboxylic ester hydrolase activity
ZHX2020_14370	COG2132	Multicopper oxidase
ZHX2020_14375	COG1113	amino acid transport
ZHX2020_14385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ZHX2020_14390	COG0714	Associated with various cellular activities
ZHX2020_14395	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ZHX2020_14400	COG1305	Transglutaminase-like
ZHX2020_14405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZHX2020_14405	COG0519	Catalyzes the synthesis of GMP from XMP
ZHX2020_14415	COG2252	PERMEase
ZHX2020_14420	COG3064	Membrane
ZHX2020_14430	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ZHX2020_14440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZHX2020_14445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZHX2020_14450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ZHX2020_14455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZHX2020_14460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZHX2020_14465	COG0047	phosphoribosylformylglycinamidine synthase activity
ZHX2020_14470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZHX2020_14475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZHX2020_14480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZHX2020_14485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZHX2020_14490	COG0138	bifunctional purine biosynthesis protein purh
ZHX2020_14495	COG0151	Belongs to the GarS family
ZHX2020_14500	COG1522	sequence-specific DNA binding
ZHX2020_14505	COG0531	amino acid
ZHX2020_14515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ZHX2020_14520	COG1470	cell adhesion involved in biofilm formation
ZHX2020_14525	COG4496	protein, YerC YecD
ZHX2020_14530	COG0069	glutamate synthase activity
ZHX2020_14535	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ZHX2020_14540	COG0210	DNA helicase
ZHX2020_14545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZHX2020_14550	COG4851	CamS sex pheromone cAM373 precursor
ZHX2020_14560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZHX2020_14565	COG1285	pathogenesis
ZHX2020_14570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ZHX2020_14575	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZHX2020_14580	COG0154	amidase activity
ZHX2020_14585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZHX2020_14590	COG1309	transcriptional regulator
ZHX2020_14595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZHX2020_14600	COG1597	lipid kinase activity
ZHX2020_14605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZHX2020_14635	COG5444	nuclease activity
ZHX2020_14645	COG0457	Tetratricopeptide repeat
ZHX2020_14655	COG0217	transcriptional regulatory protein
ZHX2020_14665	COG1309	transcriptional regulator
ZHX2020_14680	COG3546	catalase activity
ZHX2020_14685	COG0454	-acetyltransferase
ZHX2020_14695	COG5578	integral membrane protein
ZHX2020_14700	COG2972	Histidine kinase
ZHX2020_14710	COG1653	transport
ZHX2020_14715	COG1175	transmembrane transport
ZHX2020_14720	COG0395	ABC-type sugar transport system, permease component
ZHX2020_14725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ZHX2020_14730	COG2207	Transcriptional regulator
ZHX2020_14735	COG2755	lipolytic protein G-D-S-L family
ZHX2020_14745	COG5578	integral membrane protein
ZHX2020_14750	COG3401	FG-GAP repeat protein
ZHX2020_14755	COG3401	FG-GAP repeat protein
ZHX2020_14760	COG2755	lipolytic protein G-D-S-L family
ZHX2020_14775	COG1653	transport
ZHX2020_14780	COG4209	transmembrane transport
ZHX2020_14785	COG0395	ABC-type sugar transport system, permease component
ZHX2020_14790	COG1486	melibiose metabolic process
ZHX2020_14795	COG2323	membrane
ZHX2020_14800	COG2329	Antibiotic biosynthesis monooxygenase
ZHX2020_14805	COG0346	lactoylglutathione lyase activity
ZHX2020_14820	COG5583	Uncharacterized small protein (DUF2292)
ZHX2020_14825	COG0670	Belongs to the BI1 family
ZHX2020_14830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZHX2020_14840	COG3328	transposase activity
ZHX2020_14850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ZHX2020_14850	COG2124	cytochrome p450
ZHX2020_14855	COG1368	sulfuric ester hydrolase activity
ZHX2020_14860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ZHX2020_14865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZHX2020_14870	COG1442	glycosyl transferase family 8
ZHX2020_14875	COG1216	Glycosyl transferase, family 2
ZHX2020_14880	COG1442	glycosyl transferase family 8
ZHX2020_14885	COG2223	nitrite transmembrane transporter activity
ZHX2020_14890	COG1011	Hydrolase
ZHX2020_14895	COG0531	amino acid
ZHX2020_14900	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_14905	COG0840	transmembrane signaling receptor activity
ZHX2020_14910	COG0488	(ABC) transporter
ZHX2020_14920	COG0789	Transcriptional regulator
ZHX2020_14925	COG2814	Major facilitator Superfamily
ZHX2020_14940	COG0488	(ABC) transporter
ZHX2020_14945	COG0513	Belongs to the DEAD box helicase family
ZHX2020_14955	COG3866	Pectate lyase
ZHX2020_14960	COG0471	metal ion transport
ZHX2020_14965	COG3290	protein histidine kinase activity
ZHX2020_14970	COG4565	transcriptional regulatory protein
ZHX2020_14975	COG3181	Tripartite tricarboxylate transporter family receptor
ZHX2020_14980	COG2851	Citrate transporter
ZHX2020_14985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZHX2020_14990	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ZHX2020_14995	COG1254	Belongs to the acylphosphatase family
ZHX2020_15000	COG2258	MOSC domain
ZHX2020_15020	COG0024	Methionine aminopeptidase
ZHX2020_15025	COG1263	PTS System
ZHX2020_15025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_15030	COG1368	sulfuric ester hydrolase activity
ZHX2020_15045	COG1115	amino acid carrier protein
ZHX2020_15060	COG0697	spore germination
ZHX2020_15065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_15065	COG1263	PTS System
ZHX2020_15070	COG0366	Alpha amylase catalytic
ZHX2020_15075	COG2188	Transcriptional regulator
ZHX2020_15080	COG0778	Nitroreductase
ZHX2020_15085	COG0737	Belongs to the 5'-nucleotidase family
ZHX2020_15090	COG0693	protein deglycase activity
ZHX2020_15100	COG2814	Major facilitator Superfamily
ZHX2020_15105	COG4840	Belongs to the UPF0435 family
ZHX2020_15110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZHX2020_15115	COG4980	gas vesicle protein
ZHX2020_15120	COG1295	ribonuclease BN
ZHX2020_15125	COG0477	Major facilitator Superfamily
ZHX2020_15130	COG0387	Pfam Sodium calcium exchanger
ZHX2020_15140	COG0668	transmembrane transport
ZHX2020_15145	COG0535	radical SAM domain protein
ZHX2020_15155	COG0726	polysaccharide deacetylase
ZHX2020_15160	COG2084	Dehydrogenase
ZHX2020_15165	COG0598	Magnesium transport protein CorA
ZHX2020_15170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ZHX2020_15175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZHX2020_15185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ZHX2020_15190	COG4637	Psort location Cytoplasmic, score
ZHX2020_15200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZHX2020_15205	COG0022	dehydrogenase e1 component
ZHX2020_15210	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZHX2020_15215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZHX2020_15220	COG3284	Transcriptional regulator
ZHX2020_15230	COG1742	UPF0060 membrane protein
ZHX2020_15255	COG4842	Belongs to the WXG100 family
ZHX2020_15260	COG1486	melibiose metabolic process
ZHX2020_15265	COG1737	Transcriptional regulator
ZHX2020_15270	COG1263	PTS System
ZHX2020_15270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_15275	COG5434	Belongs to the glycosyl hydrolase 28 family
ZHX2020_15280	COG1132	(ABC) transporter
ZHX2020_15285	COG1132	(ABC) transporter
ZHX2020_15290	COG2259	Doxx family
ZHX2020_15295	COG2514	catechol 2,3-dioxygenase activity
ZHX2020_15300	COG1917	Cupin 2, conserved barrel domain protein
ZHX2020_15300	COG4977	sequence-specific DNA binding
ZHX2020_15305	COG2814	Major facilitator Superfamily
ZHX2020_15310	COG1082	Xylose isomerase domain protein TIM barrel
ZHX2020_15320	COG4585	Histidine kinase
ZHX2020_15325	COG2197	response regulator
ZHX2020_15330	COG1131	(ABC) transporter
ZHX2020_15335	COG1511	domain protein
ZHX2020_15335	COG0842	Transport permease protein
ZHX2020_15340	COG0842	Transport permease protein
ZHX2020_15345	COG1695	Transcriptional regulator
ZHX2020_15350	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ZHX2020_15355	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ZHX2020_15360	COG1309	transcriptional regulator
ZHX2020_15365	COG2814	Major facilitator Superfamily
ZHX2020_15370	COG2318	DinB family
ZHX2020_15380	COG1846	Transcriptional regulator
ZHX2020_15385	COG0392	lysyltransferase activity
ZHX2020_15385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ZHX2020_15390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZHX2020_15395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_15400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZHX2020_15405	COG0384	phenazine biosynthesis protein PhzF
ZHX2020_15410	COG0778	Nitroreductase
ZHX2020_15425	COG1090	epimerase
ZHX2020_15430	COG2137	regulation of response to DNA damage stimulus
ZHX2020_15440	COG2814	Major facilitator Superfamily
ZHX2020_15455	COG3103	Sh3 type 3 domain protein
ZHX2020_15460	COG5658	integral membrane protein
ZHX2020_15465	COG0596	Alpha beta hydrolase
ZHX2020_15470	COG0463	Glycosyl transferase, family 2
ZHX2020_15475	COG4485	Bacterial membrane protein, YfhO
ZHX2020_15480	COG1988	membrane-bound metal-dependent
ZHX2020_15485	COG1194	a g-specific adenine glycosylase
ZHX2020_15495	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_15510	COG3557	Belongs to the UPF0374 family
ZHX2020_15515	COG1132	(ABC) transporter
ZHX2020_15520	COG4129	membrane
ZHX2020_15525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ZHX2020_15530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ZHX2020_15535	COG0735	belongs to the Fur family
ZHX2020_15645	COG4326	sporulation control protein
ZHX2020_15655	COG5577	PFAM Coat F domain
ZHX2020_15660	COG3340	Belongs to the peptidase S51 family
ZHX2020_15665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZHX2020_15680	COG0753	catalase activity
ZHX2020_15685	COG1116	anion transmembrane transporter activity
ZHX2020_15690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ZHX2020_15695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZHX2020_15700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZHX2020_15710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZHX2020_15720	COG1476	TRANSCRIPTIONal
ZHX2020_15730	COG3382	B3 4 domain protein
ZHX2020_15735	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZHX2020_15745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ZHX2020_15750	COG0789	Transcriptional regulator
ZHX2020_15755	COG1664	Polymer-forming cytoskeletal
ZHX2020_15760	COG1664	Polymer-forming cytoskeletal
ZHX2020_15765	COG2766	serine protein kinase
ZHX2020_15770	COG2718	Belongs to the UPF0229 family
ZHX2020_15775	COG1846	Transcriptional regulator
ZHX2020_15780	COG1566	PFAM secretion protein HlyD family protein
ZHX2020_15785	COG2814	Major facilitator Superfamily
ZHX2020_15790	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZHX2020_15810	COG1725	Transcriptional regulator
ZHX2020_15815	COG1131	(ABC) transporter
ZHX2020_15820	COG1131	(ABC) transporter
ZHX2020_15825	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ZHX2020_15830	COG1278	Cold shock
ZHX2020_15835	COG1464	Belongs to the NlpA lipoprotein family
ZHX2020_15840	COG3706	GGDEF domain
ZHX2020_15845	COG1823	symporter activity
ZHX2020_15850	COG5444	nuclease activity
ZHX2020_15875	COG0582	viral genome integration into host DNA
ZHX2020_15880	COG2946	Replication initiation factor
ZHX2020_15935	COG5644	endopeptidase inhibitor activity
ZHX2020_15940	COG0741	lytic transglycosylase activity
ZHX2020_15940	COG0791	NLP P60 protein
ZHX2020_15960	COG0457	Tetratricopeptide repeat
ZHX2020_15985	COG1525	nuclease
ZHX2020_15985	COG4085	toxin activity
ZHX2020_15985	COG0737	Belongs to the 5'-nucleotidase family
ZHX2020_15990	COG3764	Sortase (surface protein transpeptidase)
ZHX2020_15995	COG0564	pseudouridine synthase activity
ZHX2020_16005	COG0517	IMP dehydrogenase activity
ZHX2020_16010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZHX2020_16015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZHX2020_16015	COG3153	acetyltransferase
ZHX2020_16020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZHX2020_16025	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ZHX2020_16030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ZHX2020_16035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ZHX2020_16040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ZHX2020_16045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZHX2020_16050	COG2203	Gaf domain
ZHX2020_16050	COG4585	Histidine kinase
ZHX2020_16055	COG2197	response regulator
ZHX2020_16060	COG0431	NADPH-dependent FMN reductase
ZHX2020_16075	COG0791	NLP P60 protein
ZHX2020_16075	COG1388	LysM domain
ZHX2020_16080	COG1959	2 iron, 2 sulfur cluster binding
ZHX2020_16085	COG0668	transmembrane transport
ZHX2020_16090	COG2719	SpoVR family
ZHX2020_16095	COG1785	Belongs to the alkaline phosphatase family
ZHX2020_16100	COG1388	LysM domain
ZHX2020_16100	COG0791	NLP P60 protein
ZHX2020_16105	COG0583	DNA-binding transcription factor activity
ZHX2020_16110	COG0372	Belongs to the citrate synthase family
ZHX2020_16115	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_16120	COG0531	amino acid
ZHX2020_16125	COG0733	neurotransmitter:sodium symporter activity
ZHX2020_16130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZHX2020_16135	COG0456	acetyltransferase
ZHX2020_16150	COG1595	DNA-templated transcription, initiation
ZHX2020_16155	COG0667	Aldo Keto reductase
ZHX2020_16160	COG0204	Acyl-transferase
ZHX2020_16165	COG1253	flavin adenine dinucleotide binding
ZHX2020_16170	COG0789	Transcriptional regulator
ZHX2020_16180	COG1253	flavin adenine dinucleotide binding
ZHX2020_16185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ZHX2020_16190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ZHX2020_16195	COG0584	glycerophosphoryl diester phosphodiesterase
ZHX2020_16205	COG0668	transmembrane transport
ZHX2020_16210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ZHX2020_16215	COG0726	polysaccharide deacetylase
ZHX2020_16220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZHX2020_16225	COG1757	Na H antiporter
ZHX2020_16230	COG0589	response to stress
ZHX2020_16240	COG1132	(ABC) transporter
ZHX2020_16245	COG1132	(ABC) transporter
ZHX2020_16250	COG0702	epimerase
ZHX2020_16275	COG0189	ligase activity
ZHX2020_16280	COG0189	ligase activity
ZHX2020_16285	COG4399	Belongs to the UPF0754 family
ZHX2020_16290	COG3679	Belongs to the UPF0342 family
ZHX2020_16300	COG0561	phosphatase activity
ZHX2020_16305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZHX2020_16310	COG0475	glutathione-regulated potassium exporter activity
ZHX2020_16315	COG0490	domain, Protein
ZHX2020_16325	COG1024	Enoyl-CoA hydratase
ZHX2020_16335	COG4152	abc transporter atp-binding protein
ZHX2020_16340	COG1668	transmembrane transport
ZHX2020_16345	COG0420	3'-5' exonuclease activity
ZHX2020_16350	COG4717	serine-type aminopeptidase activity
ZHX2020_16355	COG3481	metal-dependent phosphohydrolase, HD sub domain
ZHX2020_16365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZHX2020_16395	COG1846	Transcriptional regulator
ZHX2020_16400	COG4980	gas vesicle protein
ZHX2020_16415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ZHX2020_16420	COG0537	adenosine 5'-monophosphoramidase activity
ZHX2020_16425	COG1131	(ABC) transporter
ZHX2020_16430	COG4473	ABC transporter
ZHX2020_16440	COG1473	amidohydrolase
ZHX2020_16445	COG3069	C4-dicarboxylate transmembrane transporter activity
ZHX2020_16455	COG2329	Antibiotic biosynthesis monooxygenase
ZHX2020_16460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZHX2020_16465	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZHX2020_16470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZHX2020_16475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ZHX2020_16480	COG1309	transcriptional regulator
ZHX2020_16485	COG1511	domain protein
ZHX2020_16490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZHX2020_16495	COG4377	Putative membrane peptidase family (DUF2324)
ZHX2020_16505	COG1363	Peptidase, m42
ZHX2020_16510	COG4405	Protein conserved in bacteria
ZHX2020_16515	COG1301	dicarboxylic acid transport
ZHX2020_16525	COG1234	tRNA 3'-trailer cleavage
ZHX2020_16530	COG0095	Lipoate-protein ligase
ZHX2020_16535	COG0702	epimerase
ZHX2020_16540	COG0318	PFAM AMP-dependent synthetase and ligase
ZHX2020_16550	COG0501	Belongs to the peptidase M48B family
ZHX2020_16560	COG0456	acetyltransferase
ZHX2020_16565	COG0604	alcohol dehydrogenase
ZHX2020_16570	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ZHX2020_16575	COG0406	alpha-ribazole phosphatase activity
ZHX2020_16580	COG0183	Belongs to the thiolase family
ZHX2020_16585	COG0318	PFAM AMP-dependent synthetase and ligase
ZHX2020_16590	COG1268	BioY protein
ZHX2020_16595	COG0840	transmembrane signaling receptor activity
ZHX2020_16605	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_16615	COG4903	ComK protein
ZHX2020_16620	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_16630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ZHX2020_16645	COG0398	Pfam SNARE associated Golgi protein
ZHX2020_16650	COG0681	Belongs to the peptidase S26 family
ZHX2020_16655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZHX2020_16660	COG1846	Transcriptional regulator
ZHX2020_16670	COG0738	Major facilitator superfamily
ZHX2020_16675	COG0673	inositol 2-dehydrogenase activity
ZHX2020_16680	COG0561	phosphatase activity
ZHX2020_16685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ZHX2020_16690	COG1609	Transcriptional regulator
ZHX2020_16695	COG3180	Ammonia monooxygenase
ZHX2020_16700	COG0477	Major facilitator Superfamily
ZHX2020_16700	COG2814	Major facilitator Superfamily
ZHX2020_16705	COG4533	DNA binding
ZHX2020_16720	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ZHX2020_16725	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ZHX2020_16730	COG1074	ATP-dependent DNA helicase activity
ZHX2020_16735	COG0420	3'-5' exonuclease activity
ZHX2020_16740	COG0419	ATPase involved in DNA repair
ZHX2020_16745	COG1403	HNH endonuclease
ZHX2020_16785	COG5337	Spore coat protein CotH
ZHX2020_16790	COG0179	Fumarylacetoacetate (FAA) hydrolase
ZHX2020_16800	COG1404	Belongs to the peptidase S8 family
ZHX2020_16810	COG0367	asparagine synthase
ZHX2020_16815	COG1562	ergosterol biosynthetic process
ZHX2020_16820	COG0534	Mate efflux family protein
ZHX2020_16825	COG1917	Cupin 2, conserved barrel domain protein
ZHX2020_16825	COG2207	Transcriptional regulator
ZHX2020_16830	COG1609	Transcriptional regulator
ZHX2020_16835	COG0673	inositol 2-dehydrogenase activity
ZHX2020_16840	COG2318	DinB family
ZHX2020_16845	COG1279	arginine transmembrane transporter activity
ZHX2020_16850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZHX2020_16855	COG1357	PFAM Pentapeptide repeats (8 copies)
ZHX2020_16860	COG2267	carboxylic ester hydrolase activity
ZHX2020_16870	COG2153	protein acetylation
ZHX2020_16875	COG0646	methionine synthase
ZHX2020_16875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ZHX2020_16880	COG1666	GTP binding
ZHX2020_16885	COG2996	Protein conserved in bacteria
ZHX2020_16895	COG1307	EDD domain protein, DegV family
ZHX2020_16900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ZHX2020_16920	COG0561	phosphatase activity
ZHX2020_16925	COG1073	alpha beta
ZHX2020_16930	COG2151	metal-sulfur cluster biosynthetic enzyme
ZHX2020_16950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ZHX2020_16955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ZHX2020_16965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZHX2020_16970	COG0505	Belongs to the CarA family
ZHX2020_16975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ZHX2020_16980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZHX2020_17000	COG2267	carboxylic ester hydrolase activity
ZHX2020_17010	COG1744	ABC transporter substrate-binding protein PnrA-like
ZHX2020_17025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZHX2020_17030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZHX2020_17035	COG5504	Zn-dependent protease
ZHX2020_17040	COG0444	Belongs to the ABC transporter superfamily
ZHX2020_17045	COG4608	Belongs to the ABC transporter superfamily
ZHX2020_17055	COG0601	transmembrane transport
ZHX2020_17060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZHX2020_17070	COG0180	Tryptophanyl-tRNA synthetase
ZHX2020_17075	COG4166	transmembrane transport
ZHX2020_17080	COG0601	transmembrane transport
ZHX2020_17085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZHX2020_17090	COG0444	Belongs to the ABC transporter superfamily
ZHX2020_17095	COG4608	Belongs to the ABC transporter superfamily
ZHX2020_17100	COG2814	Major facilitator Superfamily
ZHX2020_17105	COG0456	acetyltransferase
ZHX2020_17110	COG1393	Belongs to the ArsC family
ZHX2020_17115	COG0861	Integral membrane protein TerC family
ZHX2020_17125	COG4862	establishment of competence for transformation
ZHX2020_17135	COG4469	Competence protein
ZHX2020_17140	COG1164	Oligoendopeptidase f
ZHX2020_17150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ZHX2020_17155	COG2346	COG2346, Truncated hemoglobins
ZHX2020_17160	COG0741	lytic transglycosylase activity
ZHX2020_17165	COG4116	CYTH
ZHX2020_17175	COG2357	RelA SpoT domain protein
ZHX2020_17180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZHX2020_17185	COG0564	pseudouridine synthase activity
ZHX2020_17190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ZHX2020_17195	COG0475	glutathione-regulated potassium exporter activity
ZHX2020_17195	COG0569	domain protein
ZHX2020_17200	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ZHX2020_17205	COG0352	thiamine-phosphate diphosphorylase activity
ZHX2020_17210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZHX2020_17215	COG2104	thiamine diphosphate biosynthetic process
ZHX2020_17220	COG2022	thiamine diphosphate biosynthetic process
ZHX2020_17225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZHX2020_17230	COG0351	phosphomethylpyrimidine kinase
ZHX2020_17235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZHX2020_17290	COG0210	DNA helicase
ZHX2020_17300	COG2153	protein acetylation
ZHX2020_17305	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ZHX2020_17310	COG2382	esterase
ZHX2020_17315	COG0626	cystathionine gamma-synthase activity
ZHX2020_17320	COG0626	cystathionine gamma-synthase activity
ZHX2020_17325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_17330	COG5505	Protein of unknown function (DUF819)
ZHX2020_17360	COG1396	sequence-specific DNA binding
ZHX2020_17435	COG0457	Tetratricopeptide repeat
ZHX2020_17440	COG5444	nuclease activity
ZHX2020_17450	COG3328	transposase activity
ZHX2020_17500	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ZHX2020_17510	COG3711	transcriptional antiterminator
ZHX2020_17510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_17515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ZHX2020_17515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ZHX2020_17515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_17520	COG1482	cell wall glycoprotein biosynthetic process
ZHX2020_17530	COG3328	transposase activity
ZHX2020_17535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_17545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZHX2020_17560	COG0109	protoheme IX farnesyltransferase activity
ZHX2020_17570	COG0726	polysaccharide deacetylase
ZHX2020_17585	COG5504	Zn-dependent protease
ZHX2020_17590	COG2205	protein histidine kinase activity
ZHX2020_17605	COG2427	Protein of unknown function (DUF1641)
ZHX2020_17615	COG1051	belongs to the nudix hydrolase family
ZHX2020_17625	COG2124	cytochrome p450
ZHX2020_17630	COG1819	glycosyl
ZHX2020_17640	COG1587	Uroporphyrinogen-III synthase
ZHX2020_17645	COG0390	transport system, permease component
ZHX2020_17650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZHX2020_17655	COG0697	spore germination
ZHX2020_17670	COG1252	NADH dehydrogenase
ZHX2020_17675	COG1904	glucuronate isomerase
ZHX2020_17680	COG2211	Major facilitator Superfamily
ZHX2020_17685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ZHX2020_17690	COG1063	alcohol dehydrogenase
ZHX2020_17695	COG1312	Catalyzes the dehydration of D-mannonate
ZHX2020_17700	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_17705	COG2271	Major facilitator Superfamily
ZHX2020_17710	COG1609	Transcriptional regulator
ZHX2020_17715	COG0246	Mannitol dehydrogenase
ZHX2020_17720	COG2721	sulfolactate sulfo-lyase activity
ZHX2020_17725	COG0730	response to heat
ZHX2020_17730	COG2318	DinB family
ZHX2020_17750	COG0457	Tetratricopeptide repeat
ZHX2020_17765	COG1388	LysM domain
ZHX2020_17765	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_17765	COG5632	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_17775	COG4195	phage-related replication protein
ZHX2020_17780	COG3546	catalase activity
ZHX2020_17785	COG2856	Zn peptidase
ZHX2020_17790	COG1396	sequence-specific DNA binding
ZHX2020_17800	COG1522	sequence-specific DNA binding
ZHX2020_17805	COG1484	DNA-dependent DNA replication
ZHX2020_17825	COG1595	DNA-templated transcription, initiation
ZHX2020_17830	COG5484	DNA packaging
ZHX2020_17830	COG3728	DNA packaging
ZHX2020_17835	COG1783	phage Terminase large subunit
ZHX2020_17840	COG5518	Phage portal protein
ZHX2020_17845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ZHX2020_17850	COG4653	Phage capsid family
ZHX2020_17900	COG3953	SLT domain
ZHX2020_17900	COG5412	phage tail tape measure protein
ZHX2020_17900	COG3953	SLT domain
ZHX2020_17900	COG5412	phage tail tape measure protein
ZHX2020_17900	COG5412	phage tail tape measure protein
ZHX2020_17900	COG3953	SLT domain
ZHX2020_17905	COG1652	LysM domain
ZHX2020_17910	COG4193	domain, Protein
ZHX2020_17920	COG3628	GPW Gp25 family protein
ZHX2020_17925	COG3299	homolog of phage Mu protein gp47
ZHX2020_17930	COG3778	Protein conserved in bacteria
ZHX2020_17970	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_17970	COG5632	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_17990	COG0306	phosphate transporter
ZHX2020_17995	COG1392	Phosphate transport regulator
ZHX2020_18000	COG0531	amino acid
ZHX2020_18005	COG0346	lactoylglutathione lyase activity
ZHX2020_18010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ZHX2020_18015	COG0463	Glycosyl transferase, family 2
ZHX2020_18020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZHX2020_18025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZHX2020_18030	COG2362	D-Aminopeptidase
ZHX2020_18035	COG0601	transmembrane transport
ZHX2020_18040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZHX2020_18045	COG0444	Belongs to the ABC transporter superfamily
ZHX2020_18050	COG4166	transmembrane transport
ZHX2020_18055	COG1619	proteins homologs of microcin C7 resistance protein MccF
ZHX2020_18060	COG4948	Mandelate Racemase Muconate Lactonizing
ZHX2020_18065	COG0791	NLP P60 protein
ZHX2020_18070	COG4608	Belongs to the ABC transporter superfamily
ZHX2020_18075	COG2706	6-phosphogluconolactonase activity
ZHX2020_18085	COG1607	acyl-coa hydrolase
ZHX2020_18090	COG1017	nitric oxide dioxygenase activity
ZHX2020_18090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ZHX2020_18100	COG2323	membrane
ZHX2020_18105	COG2318	DinB family
ZHX2020_18110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_18115	COG2076	Multidrug Resistance protein
ZHX2020_18120	COG2076	Multidrug Resistance protein
ZHX2020_18125	COG0788	formyltetrahydrofolate deformylase activity
ZHX2020_18130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZHX2020_18135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZHX2020_18140	COG1764	response to oxidative stress
ZHX2020_18150	COG1846	Transcriptional regulator
ZHX2020_18155	COG1764	response to oxidative stress
ZHX2020_18165	COG0590	tRNA wobble adenosine to inosine editing
ZHX2020_18170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZHX2020_18175	COG1404	Belongs to the peptidase S8 family
ZHX2020_18180	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_18185	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ZHX2020_18190	COG1122	ATPase activity
ZHX2020_18195	COG4721	ABC-type cobalt transport system, permease component
ZHX2020_18205	COG0745	RESPONSE REGULATOR receiver
ZHX2020_18210	COG5002	protein histidine kinase activity
ZHX2020_18210	COG3850	Histidine kinase
ZHX2020_18215	COG3212	peptidase
ZHX2020_18220	COG3212	peptidase
ZHX2020_18230	COG2239	Acts as a magnesium transporter
ZHX2020_18235	COG0789	Transcriptional regulator
ZHX2020_18250	COG1846	Transcriptional regulator
ZHX2020_18255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZHX2020_18260	COG0726	polysaccharide deacetylase
ZHX2020_18265	COG1408	metallophosphoesterase
ZHX2020_18275	COG0463	Glycosyl transferase, family 2
ZHX2020_18280	COG3285	dna ligase
ZHX2020_18280	COG1793	dna ligase
ZHX2020_18285	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ZHX2020_18290	COG3300	MHYT domain
ZHX2020_18290	COG5001	Diguanylate cyclase
ZHX2020_18295	COG0586	Pfam SNARE associated Golgi protein
ZHX2020_18300	COG0861	Integral membrane protein TerC family
ZHX2020_18305	COG1191	sigma factor activity
ZHX2020_18325	COG0501	Belongs to the peptidase M48B family
ZHX2020_18330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZHX2020_18350	COG3594	Acyltransferase
ZHX2020_18355	COG5002	protein histidine kinase activity
ZHX2020_18360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZHX2020_18370	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ZHX2020_18375	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ZHX2020_18380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZHX2020_18385	COG0436	Aminotransferase
ZHX2020_18390	COG1850	ribulose-bisphosphate carboxylase activity
ZHX2020_18395	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ZHX2020_18400	COG0235	Class ii aldolase
ZHX2020_18405	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ZHX2020_18410	COG3339	Conserved Protein
ZHX2020_18425	COG3852	Histidine kinase
ZHX2020_18430	COG1846	Transcriptional regulator
ZHX2020_18435	COG1360	Flagellar Motor Protein
ZHX2020_18440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ZHX2020_18445	COG0542	response to heat
ZHX2020_18450	COG3949	Membrane
ZHX2020_18455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ZHX2020_18460	COG0720	synthase
ZHX2020_18465	COG0602	queuosine metabolic process
ZHX2020_18470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZHX2020_18480	COG4873	Protein conserved in bacteria
ZHX2020_18490	COG3773	Cell wall hydrolase
ZHX2020_18495	COG2244	polysaccharide biosynthetic process
ZHX2020_18500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_18505	COG2217	Heavy metal translocating P-type atpase
ZHX2020_18515	COG0006	proline dipeptidase activity
ZHX2020_18520	COG1609	Transcriptional regulator
ZHX2020_18525	COG3711	transcriptional antiterminator
ZHX2020_18530	COG2190	(PTS) system
ZHX2020_18530	COG1263	PTS System
ZHX2020_18530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZHX2020_18535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_18540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ZHX2020_18550	COG1533	DNA photolyase activity
ZHX2020_18555	COG0456	acetyltransferase
ZHX2020_18560	COG0840	transmembrane signaling receptor activity
ZHX2020_18565	COG2084	Dehydrogenase
ZHX2020_18570	COG3328	transposase activity
ZHX2020_18575	COG2340	Cysteine-rich secretory protein family
ZHX2020_18580	COG0768	penicillin binding
ZHX2020_18585	COG4191	Histidine kinase
ZHX2020_18590	COG0436	Aminotransferase
ZHX2020_18600	COG0784	Response regulator, receiver
ZHX2020_18600	COG0835	chemotaxis
ZHX2020_18610	COG2814	Major facilitator Superfamily
ZHX2020_18615	COG1376	ErfK ybiS ycfS ynhG family protein
ZHX2020_18620	COG1408	metallophosphoesterase
ZHX2020_18625	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_18630	COG2200	EAL domain
ZHX2020_18635	COG4703	Protein of unknown function (DUF1797)
ZHX2020_18640	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ZHX2020_18650	COG0517	IMP dehydrogenase activity
ZHX2020_18655	COG0583	DNA-binding transcription factor activity
ZHX2020_18660	COG0716	FMN binding
ZHX2020_18670	COG0716	FMN binding
ZHX2020_18675	COG2171	N-acyltransferase activity
ZHX2020_18680	COG1473	amidohydrolase
ZHX2020_18690	COG0668	transmembrane transport
ZHX2020_18695	COG0450	alkyl hydroperoxide reductase
ZHX2020_18700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_18720	COG0746	molybdenum cofactor guanylyltransferase activity
ZHX2020_18725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZHX2020_18730	COG0303	'Molybdopterin
ZHX2020_18735	COG1763	Mo-molybdopterin cofactor biosynthetic process
ZHX2020_18740	COG0314	molybdopterin synthase activity
ZHX2020_18745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ZHX2020_18755	COG1132	(ABC) transporter
ZHX2020_18765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZHX2020_18770	COG1136	(ABC) transporter
ZHX2020_18775	COG0577	efflux transmembrane transporter activity
ZHX2020_18780	COG1349	DNA-binding transcription factor activity
ZHX2020_18785	COG1105	Belongs to the carbohydrate kinase PfkB family
ZHX2020_18790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZHX2020_18790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ZHX2020_18790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ZHX2020_18795	COG0681	Belongs to the peptidase S26 family
ZHX2020_18805	COG0488	(ABC) transporter
ZHX2020_18810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ZHX2020_18815	COG2309	aminopeptidase activity
ZHX2020_18825	COG1077	Cell shape determining protein MreB Mrl
ZHX2020_18830	COG2002	toxin-antitoxin pair type II binding
ZHX2020_18835	COG3852	Histidine kinase
ZHX2020_18840	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ZHX2020_18840	COG2105	PFAM AIG2 family protein
ZHX2020_18845	COG0569	domain protein
ZHX2020_18850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ZHX2020_18855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ZHX2020_18860	COG5503	Protein of unknown function (DUF1447)
ZHX2020_18865	COG0561	phosphatase activity
ZHX2020_18870	COG0242	peptide deformylase activity
ZHX2020_18885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZHX2020_18890	COG0022	dehydrogenase e1 component
ZHX2020_18895	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZHX2020_18900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZHX2020_18905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_18915	COG1982	Orn Lys Arg decarboxylase major
ZHX2020_18920	COG4476	Belongs to the UPF0223 family
ZHX2020_18925	COG4493	Belongs to the UPF0637 family
ZHX2020_18935	COG0483	inositol monophosphate 1-phosphatase activity
ZHX2020_18950	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ZHX2020_18990	COG1217	gtp-binding protein TYPA
ZHX2020_19000	COG4896	Protein conserved in bacteria
ZHX2020_19010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ZHX2020_19015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ZHX2020_19020	COG2066	Belongs to the glutaminase family
ZHX2020_19025	COG4838	Belongs to the UPF0358 family
ZHX2020_19030	COG0772	Belongs to the SEDS family
ZHX2020_19035	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ZHX2020_19040	COG1612	heme a metabolic process
ZHX2020_19045	COG0109	protoheme IX farnesyltransferase activity
ZHX2020_19050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ZHX2020_19050	COG2010	Cytochrome c
ZHX2020_19055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ZHX2020_19060	COG1845	cytochrome c oxidase, subunit III
ZHX2020_19065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ZHX2020_19070	COG3336	cytochrome c oxidase
ZHX2020_19080	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ZHX2020_19085	COG2340	Cysteine-rich secretory protein family
ZHX2020_19100	COG3679	Belongs to the UPF0342 family
ZHX2020_19105	COG4471	UPF0298 protein
ZHX2020_19110	COG0742	ribosomal rna small subunit methyltransferase
ZHX2020_19115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZHX2020_19120	COG3314	Sporulation integral membrane protein YlbJ
ZHX2020_19125	COG1752	Esterase of the alpha-beta hydrolase superfamily
ZHX2020_19130	COG3480	Lon protease (S16) C-terminal proteolytic domain
ZHX2020_19135	COG1323	Belongs to the UPF0348 family
ZHX2020_19145	COG1399	metal-binding, possibly nucleic acid-binding protein
ZHX2020_19160	COG0454	-acetyltransferase
ZHX2020_19165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ZHX2020_19170	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ZHX2020_19175	COG2001	Belongs to the MraZ family
ZHX2020_19180	COG0275	rRNA processing
ZHX2020_19185	COG4839	cell division protein FtsL
ZHX2020_19190	COG0768	penicillin binding
ZHX2020_19195	COG0768	penicillin binding
ZHX2020_19200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZHX2020_19205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZHX2020_19210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZHX2020_19215	COG0772	Belongs to the SEDS family
ZHX2020_19220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZHX2020_19225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZHX2020_19230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ZHX2020_19235	COG3879	Bacterial protein of unknown function (DUF881)
ZHX2020_19240	COG3879	Bacterial protein of unknown function (DUF881)
ZHX2020_19245	COG3856	small basic protein
ZHX2020_19250	COG0849	cell division
ZHX2020_19255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZHX2020_19260	COG1404	Belongs to the peptidase S8 family
ZHX2020_19260	COG4412	M6 family metalloprotease domain protein
ZHX2020_19270	COG1191	sigma factor activity
ZHX2020_19275	COG1191	sigma factor activity
ZHX2020_19280	COG1119	ATPase activity
ZHX2020_19285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZHX2020_19290	COG1873	PFAM PRC-barrel domain
ZHX2020_19295	COG1496	oxidoreductase activity
ZHX2020_19300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ZHX2020_19305	COG1799	cell septum assembly
ZHX2020_19310	COG0762	integral membrane protein
ZHX2020_19315	COG2302	S4 RNA-binding domain
ZHX2020_19320	COG3599	regulation of cell shape
ZHX2020_19325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZHX2020_19330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ZHX2020_19335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZHX2020_19340	COG0564	pseudouridine synthase activity
ZHX2020_19345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ZHX2020_19350	COG2233	PERMEase
ZHX2020_19355	COG0540	Belongs to the ATCase OTCase family
ZHX2020_19360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZHX2020_19365	COG0505	Belongs to the CarA family
ZHX2020_19370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ZHX2020_19375	COG0543	2 iron, 2 sulfur cluster binding
ZHX2020_19380	COG0167	dihydroorotate dehydrogenase activity
ZHX2020_19385	COG0284	orotidine-5'-phosphate decarboxylase activity
ZHX2020_19390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZHX2020_19395	COG0175	sulfate reduction
ZHX2020_19400	COG0306	phosphate transporter
ZHX2020_19405	COG2046	Belongs to the sulfate adenylyltransferase family
ZHX2020_19410	COG0529	Catalyzes the synthesis of activated sulfate
ZHX2020_19415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZHX2020_19420	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ZHX2020_19425	COG1648	precorrin-2 dehydrogenase activity
ZHX2020_19435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ZHX2020_19440	COG1561	YicC-like family, N-terminal region
ZHX2020_19450	COG0194	GDP metabolic process
ZHX2020_19455	COG1758	RNA polymerase activity
ZHX2020_19460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZHX2020_19465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ZHX2020_19470	COG0242	peptide deformylase activity
ZHX2020_19475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZHX2020_19480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZHX2020_19480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZHX2020_19485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZHX2020_19490	COG0631	protein serine/threonine phosphatase activity
ZHX2020_19495	COG2815	serine threonine protein kinase
ZHX2020_19495	COG0515	serine threonine protein kinase
ZHX2020_19500	COG1162	GTPase activity
ZHX2020_19505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZHX2020_19510	COG1564	THIamine pyrophosphokinase
ZHX2020_19520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZHX2020_19525	COG1302	Protein conserved in bacteria
ZHX2020_19530	COG1461	Dihydroxyacetone kinase
ZHX2020_19535	COG1760	l-serine dehydratase
ZHX2020_19540	COG1760	l-serine dehydratase
ZHX2020_19545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ZHX2020_19550	COG1349	DNA-binding transcription factor activity
ZHX2020_19550	COG2050	protein possibly involved in aromatic compounds catabolism
ZHX2020_19555	COG0416	fatty acid biosynthetic process
ZHX2020_19560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZHX2020_19565	COG1028	Short-chain dehydrogenase reductase Sdr
ZHX2020_19575	COG0571	ribonuclease III activity
ZHX2020_19580	COG1196	nuclear chromosome segregation
ZHX2020_19585	COG0552	protein localization to endoplasmic reticulum
ZHX2020_19595	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ZHX2020_19600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZHX2020_19605	COG0228	four-way junction DNA binding
ZHX2020_19610	COG1837	Belongs to the UPF0109 family
ZHX2020_19620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZHX2020_19625	COG0336	Belongs to the RNA methyltransferase TrmD family
ZHX2020_19630	COG0335	large ribosomal subunit rRNA binding
ZHX2020_19635	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ZHX2020_19640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZHX2020_19650	COG2257	FlhB HrpN YscU SpaS Family
ZHX2020_19655	COG0045	succinate-CoA ligase (ADP-forming) activity
ZHX2020_19660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ZHX2020_19665	COG0758	DNA mediated transformation
ZHX2020_19670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZHX2020_19675	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ZHX2020_19680	COG4974	Belongs to the 'phage' integrase family
ZHX2020_19685	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ZHX2020_19690	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ZHX2020_19695	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ZHX2020_19700	COG1815	bacterial-type flagellum-dependent cell motility
ZHX2020_19705	COG1558	bacterial-type flagellum-dependent cell motility
ZHX2020_19710	COG1677	Flagellar hook-basal body complex protein FliE
ZHX2020_19720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZHX2020_19725	COG1317	bacterial-type flagellum organization
ZHX2020_19730	COG1157	protein secretion by the type III secretion system
ZHX2020_19735	COG2882	bacterial-type flagellum organization
ZHX2020_19740	COG3334	PFAM MgtE intracellular
ZHX2020_19745	COG3144	bacterial-type flagellum assembly
ZHX2020_19750	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ZHX2020_19755	COG4786	Flagellar basal body rod
ZHX2020_19760	COG1582	Flagellar protein (FlbD)
ZHX2020_19765	COG1580	Controls the rotational direction of flagella during chemotaxis
ZHX2020_19770	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZHX2020_19775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZHX2020_19775	COG1776	CheC inhibitor of MCP methylation
ZHX2020_19780	COG2201	protein-glutamate methylesterase activity
ZHX2020_19785	COG3190	flagellar
ZHX2020_19790	COG1338	Plays a role in the flagellum-specific transport system
ZHX2020_19795	COG1987	bacterial-type flagellum assembly
ZHX2020_19800	COG1684	flagellar biosynthetic protein fliR
ZHX2020_19805	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ZHX2020_19810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ZHX2020_19815	COG1419	protein localization to endoplasmic reticulum
ZHX2020_19820	COG0455	bacterial-type flagellum organization
ZHX2020_19825	COG2201	protein-glutamate methylesterase activity
ZHX2020_19830	COG0643	Histidine kinase
ZHX2020_19830	COG2198	Histidine kinase
ZHX2020_19835	COG0835	chemotaxis
ZHX2020_19845	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ZHX2020_19850	COG1191	sigma factor activity
ZHX2020_19860	COG0052	Belongs to the universal ribosomal protein uS2 family
ZHX2020_19865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZHX2020_19870	COG0528	UMP kinase activity
ZHX2020_19875	COG0233	cytoplasmic translational termination
ZHX2020_19880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZHX2020_19885	COG4589	Belongs to the CDS family
ZHX2020_19890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ZHX2020_19895	COG0750	zinc metalloprotease
ZHX2020_19900	COG0442	prolyl-tRNA aminoacylation
ZHX2020_19905	COG2176	DNA-directed DNA polymerase activity
ZHX2020_19910	COG0779	Required for maturation of 30S ribosomal subunits
ZHX2020_19915	COG0195	Participates in both transcription termination and antitermination
ZHX2020_19920	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ZHX2020_19925	COG1358	cellular component organization or biogenesis
ZHX2020_19930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZHX2020_19935	COG1550	Protein conserved in bacteria
ZHX2020_19940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZHX2020_19945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZHX2020_19950	COG0196	riboflavin kinase activity
ZHX2020_19955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZHX2020_19960	COG1185	polyribonucleotide nucleotidyltransferase activity
ZHX2020_19965	COG0726	polysaccharide deacetylase
ZHX2020_19970	COG0612	Peptidase, M16
ZHX2020_19975	COG1873	PFAM PRC-barrel domain
ZHX2020_19980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZHX2020_19985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZHX2020_19990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZHX2020_19995	COG0527	aspartate kinase activity
ZHX2020_20000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZHX2020_20005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ZHX2020_20010	COG0740	serine-type endopeptidase activity
ZHX2020_20020	COG4980	gas vesicle protein
ZHX2020_20020	COG1674	ftsk spoiiie
ZHX2020_20025	COG2188	Transcriptional regulator
ZHX2020_20030	COG2814	Major facilitator Superfamily
ZHX2020_20035	COG0612	Peptidase, M16
ZHX2020_20040	COG0612	Peptidase, M16
ZHX2020_20045	COG0300	oxidoreductase activity
ZHX2020_20060	COG1426	Protein conserved in bacteria
ZHX2020_20065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZHX2020_20070	COG1546	Belongs to the CinA family
ZHX2020_20070	COG1058	Belongs to the CinA family
ZHX2020_20075	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZHX2020_20080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZHX2020_20085	COG1418	mRNA catabolic process
ZHX2020_20090	COG1692	metallophosphoesterase
ZHX2020_20095	COG2359	stage V sporulation protein S
ZHX2020_20100	COG1063	alcohol dehydrogenase
ZHX2020_20105	COG0156	8-amino-7-oxononanoate synthase activity
ZHX2020_20110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZHX2020_20115	COG4550	Control of competence regulator ComK, YlbF/YmcA
ZHX2020_20125	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZHX2020_20130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZHX2020_20220	COG3328	transposase activity
ZHX2020_20235	COG3226	Transcriptional regulator
ZHX2020_20245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZHX2020_20250	COG1404	Belongs to the peptidase S8 family
ZHX2020_20260	COG4195	phage-related replication protein
ZHX2020_20265	COG1764	response to oxidative stress
ZHX2020_20270	COG2076	Multidrug Resistance protein
ZHX2020_20275	COG2076	Multidrug Resistance protein
ZHX2020_20290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZHX2020_20295	COG1923	regulation of RNA biosynthetic process
ZHX2020_20310	COG1780	Probably involved in ribonucleotide reductase function
ZHX2020_20315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZHX2020_20320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZHX2020_20325	COG4112	unkown
ZHX2020_20330	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_20335	COG0464	growth
ZHX2020_20340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZHX2020_20345	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ZHX2020_20350	COG0789	Transcriptional regulator
ZHX2020_20355	COG0174	glutamine synthetase
ZHX2020_20360	COG4974	Belongs to the 'phage' integrase family
ZHX2020_20380	COG3645	SOS response
ZHX2020_20380	COG3646	Phage regulatory protein
ZHX2020_20525	COG5412	phage tail tape measure protein
ZHX2020_20525	COG3953	SLT domain
ZHX2020_20570	COG5632	N-Acetylmuramoyl-L-alanine amidase
ZHX2020_20570	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_20570	COG1388	LysM domain
ZHX2020_20580	COG5444	nuclease activity
ZHX2020_20615	COG4282	regulation of fungal-type cell wall biogenesis
ZHX2020_20650	COG3655	Transcriptional regulator
ZHX2020_20675	COG0135	phosphoribosylanthranilate isomerase activity
ZHX2020_20680	COG2211	Major facilitator Superfamily
ZHX2020_20695	COG3507	Belongs to the glycosyl hydrolase 43 family
ZHX2020_20700	COG1940	carbohydrate kinase activity
ZHX2020_20705	COG2115	Belongs to the xylose isomerase family
ZHX2020_20710	COG1070	Carbohydrate kinase
ZHX2020_20720	COG3328	transposase activity
ZHX2020_20725	COG1525	nuclease
ZHX2020_20730	COG2814	Major facilitator Superfamily
ZHX2020_20735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZHX2020_20750	COG0756	dUTP diphosphatase activity
ZHX2020_20790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZHX2020_20805	COG3832	glyoxalase III activity
ZHX2020_20845	COG4195	phage-related replication protein
ZHX2020_20855	COG0346	lactoylglutathione lyase activity
ZHX2020_20860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ZHX2020_20865	COG1388	LysM domain
ZHX2020_20870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ZHX2020_20875	COG4224	UPF0291 protein
ZHX2020_20880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ZHX2020_20890	COG3763	UPF0154 protein
ZHX2020_20900	COG0785	Cytochrome C biogenesis protein
ZHX2020_20905	COG2201	protein-glutamate methylesterase activity
ZHX2020_20910	COG4846	Membrane protein involved in cytochrome C biogenesis
ZHX2020_20920	COG0071	Belongs to the small heat shock protein (HSP20) family
ZHX2020_20935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZHX2020_20940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZHX2020_20960	COG0824	Thioesterase
ZHX2020_20970	COG4841	protein insertion into membrane
ZHX2020_20975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ZHX2020_20980	COG1832	CoA-binding protein
ZHX2020_20985	COG0187	DNA topoisomerase II activity
ZHX2020_20990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZHX2020_21000	COG1115	amino acid carrier protein
ZHX2020_21005	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ZHX2020_21015	COG5520	Belongs to the glycosyl hydrolase 30 family
ZHX2020_21025	COG2246	polysaccharide biosynthetic process
ZHX2020_21030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZHX2020_21035	COG0586	Pfam SNARE associated Golgi protein
ZHX2020_21040	COG2404	hydrolase activity, acting on ester bonds
ZHX2020_21045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ZHX2020_21050	COG1024	Enoyl-CoA hydratase
ZHX2020_21055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZHX2020_21060	COG0511	ligase activity, forming carbon-carbon bonds
ZHX2020_21065	COG0439	Biotin carboxylase
ZHX2020_21070	COG0318	PFAM AMP-dependent synthetase and ligase
ZHX2020_21075	COG1960	acyl-CoA dehydrogenase activity
ZHX2020_21085	COG1649	PFAM Uncharacterised BCR, COG1649
ZHX2020_21100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZHX2020_21105	COG2027	D-alanyl-D-alanine carboxypeptidase
ZHX2020_21110	COG2017	converts alpha-aldose to the beta-anomer
ZHX2020_21115	COG0534	Mate efflux family protein
ZHX2020_21135	COG0582	viral genome integration into host DNA
ZHX2020_21140	COG0166	Belongs to the GPI family
ZHX2020_21145	COG0405	Gamma-glutamyltransferase
ZHX2020_21150	COG0583	DNA-binding transcription factor activity
ZHX2020_21155	COG0604	alcohol dehydrogenase
ZHX2020_21160	COG0493	'glutamate synthase
ZHX2020_21165	COG0070	glutamate synthase
ZHX2020_21165	COG0069	glutamate synthase activity
ZHX2020_21165	COG0067	glutamate synthase
ZHX2020_21170	COG0583	DNA-binding transcription factor activity
ZHX2020_21200	COG0300	oxidoreductase activity
ZHX2020_21205	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ZHX2020_21215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_21230	COG1131	(ABC) transporter
ZHX2020_21240	COG2814	Major facilitator Superfamily
ZHX2020_21245	COG3328	transposase activity
ZHX2020_21275	COG3328	transposase activity
ZHX2020_21330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZHX2020_21335	COG2226	methyltransferase
ZHX2020_21340	COG2211	Major facilitator Superfamily
ZHX2020_21345	COG3328	transposase activity
ZHX2020_21375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZHX2020_21395	COG5444	nuclease activity
ZHX2020_21400	COG4282	regulation of fungal-type cell wall biogenesis
ZHX2020_21405	COG1231	oxidoreductase activity
ZHX2020_21410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZHX2020_21415	COG0662	Cupin 2, conserved barrel domain protein
ZHX2020_21415	COG2207	Transcriptional regulator
ZHX2020_21420	COG0456	acetyltransferase
ZHX2020_21425	COG1309	transcriptional regulator
ZHX2020_21430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZHX2020_21435	COG3708	Transcriptional regulator
ZHX2020_21440	COG2378	regulation of single-species biofilm formation
ZHX2020_21450	COG0640	Transcriptional regulator
ZHX2020_21455	COG0741	lytic transglycosylase activity
ZHX2020_21460	COG2322	membrane
ZHX2020_21475	COG1619	proteins homologs of microcin C7 resistance protein MccF
ZHX2020_21480	COG3239	Fatty acid desaturase
ZHX2020_21485	COG4585	Histidine kinase
ZHX2020_21490	COG2197	response regulator
ZHX2020_21495	COG1388	LysM domain
ZHX2020_21495	COG3584	3D domain protein
ZHX2020_21500	COG0514	ATP-dependent DNA helicase (RecQ)
ZHX2020_21510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ZHX2020_21515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ZHX2020_21530	COG0071	Belongs to the small heat shock protein (HSP20) family
ZHX2020_21555	COG1012	belongs to the aldehyde dehydrogenase family
ZHX2020_21560	COG1657	PFAM Prenyltransferase squalene oxidase
ZHX2020_21565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZHX2020_21570	COG0733	neurotransmitter:sodium symporter activity
ZHX2020_21575	COG0385	Bile acid
ZHX2020_21580	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZHX2020_21585	COG0567	Dehydrogenase, E1 component
ZHX2020_21590	COG4548	von Willebrand factor, type A
ZHX2020_21595	COG0714	Associated with various cellular activities
ZHX2020_21600	COG2032	superoxide dismutase activity
ZHX2020_21605	COG0791	NLP P60 protein
ZHX2020_21605	COG1388	LysM domain
ZHX2020_21610	COG1819	glycosyl
ZHX2020_21615	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ZHX2020_21620	COG0534	Mate efflux family protein
ZHX2020_21625	COG1366	Belongs to the anti-sigma-factor antagonist family
ZHX2020_21630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ZHX2020_21635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ZHX2020_21645	COG2962	Rard protein
ZHX2020_21665	COG1942	4-Oxalocrotonate Tautomerase
ZHX2020_21670	COG1733	regulation of RNA biosynthetic process
ZHX2020_21675	COG0778	Nitroreductase
ZHX2020_21685	COG0400	carboxylic ester hydrolase activity
ZHX2020_21700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ZHX2020_21705	COG0793	Belongs to the peptidase S41A family
ZHX2020_21705	COG3409	Peptidoglycan-binding domain 1 protein
ZHX2020_21710	COG2226	methyltransferase
ZHX2020_21720	COG1876	peptidase activity
ZHX2020_21725	COG0813	purine-nucleoside phosphorylase activity
ZHX2020_21740	COG0671	phosphoesterase, PA-phosphatase related
ZHX2020_21760	COG4479	Belongs to the UPF0346 family
ZHX2020_21770	COG1509	lysine 2,3-aminomutase activity
ZHX2020_21775	COG0456	acetyltransferase
ZHX2020_21780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZHX2020_21785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ZHX2020_21790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ZHX2020_21795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZHX2020_21810	COG0456	acetyltransferase
ZHX2020_21815	COG0463	Glycosyl transferase, family 2
ZHX2020_21830	COG4641	Protein conserved in bacteria
ZHX2020_21835	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ZHX2020_21850	COG1793	dna ligase
ZHX2020_21880	COG0582	viral genome integration into host DNA
ZHX2020_21895	COG0629	single-stranded DNA binding
ZHX2020_21955	COG0791	NLP P60 protein
ZHX2020_21955	COG3883	PFAM NLP P60 protein
ZHX2020_22100	COG0457	Tetratricopeptide repeat
ZHX2020_22145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZHX2020_22250	COG1525	nuclease