locus-tag class description C5I45_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C5I45_00015 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C5I45_00030 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C5I45_00035 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C5I45_00050 ENOG4107QJE Chromosome Partitioning Protein C5I45_00055 ENOG4105FA0 parb-like partition protein C5I45_00060 ENOG4108ZDA Sporulation protein YyaC C5I45_00075 ENOG4105VDK protein, conserved in bacteria C5I45_00080 ENOG4108J2R molybdopterin oxidoreductase C5I45_00085 ENOG4105C3G gtp-binding protein C5I45_00090 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C5I45_00095 ENOG4108UUM single-stranded DNA-binding protein C5I45_00100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C5I45_00110 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C5I45_00115 ENOG4105CGK Exodeoxyribonuclease III C5I45_00125 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C5I45_00135 ENOG4107FCW Abortive infection protein C5I45_00140 ENOG4105C7Z Conserved Protein C5I45_00145 ENOG4105C7Z Conserved Protein C5I45_00150 ENOG4108UQV Membrane C5I45_00155 ENOG4108Z5V transcriptional regulator, merr family C5I45_00165 ENOG4107Y9U Membrane C5I45_00200 ENOG4105DTD Dehydrogenase C5I45_00205 ENOG4105CMU LysR family (Transcriptional regulator C5I45_00210 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase C5I45_00225 ENOG4108U05 Transcriptional regulator C5I45_00235 ENOG4105FS7 Transcriptional regulator C5I45_00240 ENOG4108TVJ Nitroreductase C5I45_00260 ENOG4107XBN GntR Family Transcriptional Regulator C5I45_00265 ENOG4108HKT sucrose-6-phosphate hydrolase C5I45_00270 ENOG4105EDQ levansucrase EC 2.4.1.10 C5I45_00275 ENOG4108UZ3 Transporter C5I45_00290 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C5I45_00295 ENOG4105KVH Transcriptional regulator C5I45_00310 ENOG4108XMW Membrane C5I45_00315 ENOG4105BZR domain protein C5I45_00335 ENOG4105CPK Glycosyl transferase (Group 1 C5I45_00340 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C5I45_00350 ENOG4107QPH glycogen) synthase C5I45_00355 ENOG4105EDW glycosyl transferase, family 39 C5I45_00375 ENOG4105CDU Replicative dna helicase C5I45_00380 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C5I45_00385 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C5I45_00415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5I45_00420 ENOG4105BZU Histidine kinase C5I45_00435 ENOG4105Q2H domain protein C5I45_00440 ENOG4105C0H protease C5I45_00450 ENOG4105BZU Histidine kinase C5I45_00455 ENOG4105D06 uba thif-type nad fad binding protein C5I45_00470 ENOG4105C5H ABC transporter C5I45_00480 ENOG4108JUB Transcriptional regulator C5I45_00485 ENOG4105C8Y Acetylornithine aminotransferase C5I45_00490 ENOG4108IQI permease C5I45_00495 ENOG41066UZ arginase EC 3.5.3.1 C5I45_00505 ENOG4105WQG acetyltransferase C5I45_00510 ENOG4105CPC Aldo Keto reductase C5I45_00515 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) C5I45_00535 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C5I45_00570 ENOG4105XRQ Xanthine dehydrogenase accessory factor C5I45_00590 ENOG4108XHQ (2Fe-2S)-binding domain protein C5I45_00595 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 C5I45_00600 ENOG4105C85 amino acid C5I45_00605 ENOG4108JU3 Alkyl hydroperoxide reductase C5I45_00610 ENOG4105D3R alkyl hydroperoxide reductase C5I45_00620 ENOG41085PJ rdd domain containing protein C5I45_00625 ENOG4105F27 Major Facilitator C5I45_00630 ENOG4105WAB arsR family transcriptional regulator C5I45_00640 ENOG4108ITS PQQ enzyme repeat C5I45_00645 ENOG4105C26 Dehydrogenase C5I45_00650 ENOG4105ST3 Transcriptional regulator C5I45_00660 ENOG4105ECK Fatty Acid Desaturase C5I45_00665 ENOG4108ZGX Histidine kinase C5I45_00670 ENOG4108S01 response regulator C5I45_00675 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C5I45_00685 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C5I45_00690 ENOG4107QNK )-transporter C5I45_00695 ENOG4105CPC Aldo Keto reductase C5I45_00705 ENOG4105C26 Dehydrogenase C5I45_00715 ENOG4105EDK PfkB domain protein C5I45_00725 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C5I45_00735 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C5I45_00740 ENOG4105F0H myo-inositol catabolism protein C5I45_00745 ENOG4105WZ4 isomerase C5I45_00780 ENOG4108V5C ABC transporter C5I45_00810 ENOG410667J hydrolase C5I45_00815 ENOG4107RHR regulatoR C5I45_00820 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C5I45_00825 ENOG4105D9N nucleoside C5I45_00830 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C5I45_00840 ENOG4107W25 arginase agmatinase formiminoglutamase C5I45_00845 ENOG4105CI2 imidazolone-5-propionate hydrolase C5I45_00850 ENOG4105CGP Urocanate hydratase C5I45_00855 ENOG4105C84 Histidine ammonia-lyase C5I45_00865 ENOG4106Z5D Glycoside Hydrolase Family 43 C5I45_00870 ENOG4105M6F mutator MutT protein C5I45_00880 ENOG4107YZX Universal stress protein C5I45_00890 ENOG4108NR7 pectate lyase C5I45_00980 ENOG4105C1J atp-dependent rna helicase C5I45_00985 ENOG4105DEU major facilitator superfamily C5I45_01000 ENOG4105D4T Citrate transporter C5I45_01005 ENOG4105CH6 catalase C5I45_01025 ENOG4105DHI Methyltransferase C5I45_01040 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C5I45_01045 ENOG4105CMR udp-glucose 4-epimerase C5I45_01055 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C5I45_01070 ENOG4107BJW polysaccharide deacetylase C5I45_01075 ENOG4105D2K citrate carrier protein C5I45_01080 ENOG4105C4M (Ubiquinol oxidase) subunit I C5I45_01085 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C5I45_01090 ENOG4108JJ9 ABC, transporter C5I45_01095 ENOG4108JJ8 (ABC) transporter C5I45_01100 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C5I45_01105 ENOG4105ETS cytosine purines uracil thiamine allantoin C5I45_01110 ENOG4107QHE Choloylglycine hydrolase C5I45_01115 ENOG4105CH6 catalase C5I45_01125 ENOG4105DG6 mannose-6-phosphate isomerase C5I45_01130 ENOG4105EVU fructokinase C5I45_01135 ENOG4105CS2 ec 3.2.1.21 C5I45_01140 ENOG4105CK1 PTS System C5I45_01145 ENOG4105VCP PTS System C5I45_01150 ENOG4105VZJ PTS System C5I45_01155 ENOG4107R5R arsenical pump membrane protein C5I45_01160 ENOG41082YX Transcriptional regulator, arsr family C5I45_01170 ENOG4105EHG Permease protein C5I45_01175 ENOG4105DQ5 transport system permease protein C5I45_01190 ENOG4105EMD TRANSCRIPTIONal C5I45_01195 ENOG4105VZJ PTS System C5I45_01200 ENOG4105CK1 PTS System C5I45_01205 ENOG4105VCP PTS System C5I45_01210 ENOG4105F8D glycoside hydrolase family 4 C5I45_01215 ENOG4105CM2 brancheD-chain amino acid aminotransferase C5I45_01220 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C5I45_01225 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) C5I45_01230 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C5I45_01235 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C5I45_01255 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C5I45_01265 ENOG4105X1N Glycosyl transferase family 8 C5I45_01270 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C5I45_01275 ENOG4105CK1 PTS System C5I45_01285 ENOG4105DR4 Methyltransferase C5I45_01290 ENOG4107TXC Transcriptional regulator C5I45_01300 ENOG41067MG lrgb family C5I45_01305 ENOG4105VAW lrga family C5I45_01310 ENOG4105CMU LysR family (Transcriptional regulator C5I45_01315 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase C5I45_01320 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C5I45_01330 ENOG410650H (LipO)protein C5I45_01335 ENOG4105DBE peroxidase C5I45_01340 ENOG4107ZXU DSBA oxidoreductase C5I45_01365 ENOG4105WH5 Teichoic acid glycosylation protein C5I45_01370 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C5I45_01370 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C5I45_01380 ENOG4107BMA Transglycosylase associated protein C5I45_01385 ENOG4105E2S oxidase) subunit II C5I45_01390 ENOG4105BZ9 Cytochrome C oxidase, subunit I C5I45_01410 ENOG4105I4A GCN5-related N-acetyltransferase C5I45_01420 ENOG4108DBC nitroreductase C5I45_01425 ENOG4105DEN Luciferase family C5I45_01430 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C5I45_01445 ENOG4105C5Y PTS System C5I45_01460 ENOG4105DWF phosphomethylpyrimidine kinase C5I45_01480 ENOG4108RJ9 Glycosyl transferase, family 2 C5I45_01485 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C5I45_01520 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5I45_01525 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD C5I45_01535 ENOG4107TY6 Acylneuraminate cytidylyltransferase C5I45_01540 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG C5I45_01545 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C5I45_01550 ENOG4105C1B dTDP-glucose 4-6-dehydratase C5I45_01555 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C5I45_01560 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase C5I45_01570 ENOG4105D82 Glutamate dehydrogenase C5I45_01575 ENOG4105C26 Dehydrogenase C5I45_01590 ENOG4105C2C drug resistance transporter, Bcr CflA C5I45_01595 ENOG4105FCW Major Facilitator superfamily C5I45_01625 ENOG4105CHM Aminotransferase C5I45_01635 ENOG4107JTW chlorite dismutase C5I45_01640 ENOG4108IJ2 phosphate acetyltransferase C5I45_01645 ENOG4105HMI Membrane C5I45_01650 ENOG4105DUM transcriptional regulator, lysR family C5I45_01655 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C5I45_01670 ENOG4105K7K Transcriptional regulator C5I45_01675 ENOG4108VCI transcription factor, rsfa family C5I45_01685 ENOG4105DCI Phosphohydrolase C5I45_01695 ENOG4105CUB amino acid C5I45_01705 ENOG41067TZ transcriptional regulator, MarR family C5I45_01710 ENOG41069HH 4-oxalocrotonate tautomerase C5I45_01715 ENOG4108Z4T Peptidase M50 C5I45_01720 ENOG4108XFG YwhD family C5I45_01730 ENOG4105BZ4 penicillin-binding protein C5I45_01735 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C5I45_01740 ENOG4105CYW agmatinase C5I45_01785 ENOG4107JM4 Tetratricopeptide repeat C5I45_01790 ENOG410684U Domain of unknown function (DUF1934) C5I45_01795 ENOG4105C75 arginyL-tRNA synthetase C5I45_01805 ENOG4107V6Q Cyclic nucleotide-binding domain C5I45_01825 ENOG4108IUE nitrate reductase beta subunit C5I45_01830 ENOG4105R3A Nitrate reductase C5I45_01845 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C5I45_01850 ENOG4105BZ1 (ABC) transporter C5I45_01860 ENOG4105E5J UV damage endonuclease C5I45_01870 ENOG4105DF6 Fe-S oxidoreductase C5I45_01880 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C5I45_01890 ENOG410812K response regulator receiver protein C5I45_01895 ENOG4105D2N Aldolase C5I45_01905 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C5I45_01910 ENOG4105CBT Fructose-1,6-bisphosphatase C5I45_01915 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C5I45_01920 ENOG41082DI 50s ribosomal protein l31 C5I45_01925 ENOG4107104 thymidine kinase C5I45_01930 ENOG4105C6K Malic enzyme C5I45_01935 ENOG4107TT2 Auxin Efflux Carrier C5I45_01945 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C5I45_01950 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C5I45_01955 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C5I45_01970 ENOG4108ZXQ stage ii sporulation protein r C5I45_01980 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C5I45_01985 ENOG410815N Probably functions as a manganese efflux pump (By similarity) C5I45_01990 ENOG4107WAU Protein tyrosine phosphatase C5I45_01995 ENOG4108YZG isomerase C5I45_02000 ENOG4108UIC UPF0340 protein C5I45_02005 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C5I45_02010 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C5I45_02020 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) C5I45_02035 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C5I45_02040 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C5I45_02045 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C5I45_02050 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C5I45_02055 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C5I45_02065 ENOG4106778 Protein of unknown function (DUF1146) C5I45_02075 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C5I45_02090 ENOG4108TF4 von Willebrand factor, type A C5I45_02095 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C5I45_02100 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C5I45_02120 ENOG4108YZ9 Urea amidohydrolase subunit gamma C5I45_02125 ENOG4105KI2 Urea amidohydrolase subunit beta C5I45_02130 ENOG4105CQM Urea amidohydrolase subunit alpha C5I45_02135 ENOG4108Z40 Transcriptional regulator C5I45_02145 ENOG4107T94 Endo-14-beta-xylanase C5I45_02155 ENOG4106BRK C5I45_02160 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C5I45_02175 ENOG4107TCE N-acetyltransferase C5I45_02180 ENOG4105FRN stage II sporulation protein C5I45_02190 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C5I45_02195 ENOG4105CNI cell division protein FtsW C5I45_02205 ENOG4105BZU Histidine kinase C5I45_02210 ENOG4105D3W isochorismatase C5I45_02215 ENOG41080V3 Major Facilitator superfamily C5I45_02220 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C5I45_02225 ENOG4105CZM Major Facilitator C5I45_02230 ENOG4107MII Sugar-specific transcriptional regulator TrmB C5I45_02235 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C5I45_02240 ENOG4105DFF Rod shape-determining protein mreb C5I45_02250 ENOG4105CGA flagellar basal-body rod protein FlgG C5I45_02260 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C5I45_02265 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C5I45_02280 ENOG4105Z8H single-stranded DNA-binding protein C5I45_02285 ENOG4105E98 transcriptional regulator DeoR family C5I45_02290 ENOG410667J hydrolase C5I45_02295 ENOG4105C0D helicase C5I45_02300 ENOG4105KBK Zinc finger, swim domain protein C5I45_02315 ENOG4105HTX biosynthesis protein C5I45_02320 ENOG4107YJ4 chain length determinant protein C5I45_02325 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C5I45_02330 ENOG4105C6Y Udp-glucose 6-dehydrogenase C5I45_02335 ENOG4108XI2 Domain of unknown function (DUF1963) C5I45_02360 ENOG4107V2S Transcriptional regulator C5I45_02365 ENOG4108WS4 fmn reductase C5I45_02375 ENOG4105FGV Chromate C5I45_02380 ENOG4105CAH Chromate C5I45_02390 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C5I45_02400 ENOG4107XC4 flavin reductase domain protein, FMN-binding C5I45_02415 ENOG4106UIA C5I45_02430 ENOG4107RSM transcriptional regulator C5I45_02440 ENOG4107FQX Alpha-acetolactate decarboxylase C5I45_02445 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C5I45_02455 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C5I45_02460 ENOG4105CNN ABC, transporter C5I45_02465 ENOG4105C2J ABC transporter C5I45_02470 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C5I45_02475 ENOG4108RVA ribokinase C5I45_02480 ENOG4105ETE Transcriptional regulator (LacI family C5I45_02495 ENOG4105E1K spore germination protein C5I45_02505 ENOG4105N98 Capsule biosynthesis protein capB C5I45_02515 ENOG4105PNM synthesis protein C5I45_02525 ENOG4105K4H Nlp p60 protein C5I45_02530 ENOG4106UBQ C5I45_02535 ENOG4105J7I hydrolase C5I45_02540 ENOG4108KGH TRANSCRIPTIONal C5I45_02545 ENOG4105C54 Major Facilitator superfamily C5I45_02550 ENOG4107R8N Glycosyl transferase, family 2 C5I45_02555 ENOG4108NHD germination protein C5I45_02570 ENOG4105DG6 mannose-6-phosphate isomerase C5I45_02580 ENOG4107RZX Teichoic acid biosynthesis protein C5I45_02590 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C5I45_02600 ENOG4107SJB teichoic acid biosynthesis C5I45_02610 ENOG4105EY8 ABC transporter C5I45_02615 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C5I45_02620 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C5I45_02635 ENOG4105JFG SpoIID LytB domain protein C5I45_02640 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C5I45_02645 ENOG4105D3Q Sugar transferase C5I45_02650 ENOG4105PSV Polysaccharide Biosynthesis Protein C5I45_02655 ENOG4107RA4 Glycosyl transferase (Group 1 C5I45_02660 ENOG4105C6Y Udp-glucose 6-dehydrogenase C5I45_02665 ENOG4105QZI O-Antigen Polymerase C5I45_02680 ENOG4107EF8 Glycosyl transferase (Group 1 C5I45_02685 ENOG4105ESV Glycosyl transferase, family 4 C5I45_02690 ENOG4108KGH TRANSCRIPTIONal C5I45_02695 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C5I45_02700 ENOG4105BZU Histidine kinase C5I45_02705 ENOG4105WH1 Two component transcriptional regulator luxr family C5I45_02725 ENOG41081UC Inherit from COG: Competence protein C5I45_02730 ENOG4105RU3 C5I45_02745 ENOG4105E1Q flagellar hook-associated protein C5I45_02750 ENOG4105DTJ flagellar hook-associated protein C5I45_02760 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C5I45_02765 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C5I45_02770 ENOG4105I03 Flagellin C5I45_02775 ENOG4107RT6 flagellar hook-associated C5I45_02780 ENOG4105MQ3 flagellar protein FliS C5I45_02795 ENOG4105MS2 ribosomal subunit Interface protein C5I45_02800 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C5I45_02820 ENOG4105CAK Cell division ATP-binding protein ftsE C5I45_02825 ENOG4105CRP Part of the ABC transporter FtsEX involved in C5I45_02830 ENOG4108M26 parallel beta-helix repeat protein C5I45_02835 ENOG4105CN1 protease C5I45_02885 ENOG4105MKU Transcriptional regulator C5I45_02900 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C5I45_02905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C5I45_02920 ENOG4108PY7 C5I45_02925 ENOG41067S9 phage shock protein C, PspC C5I45_02930 ENOG41086DT Membrane protein of unknown function C5I45_02935 ENOG41088CQ domain protein C5I45_02940 ENOG4105J7D transcriptional regulator C5I45_02945 ENOG4105FDP GntR family transcriptional regulator C5I45_02950 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C5I45_02955 ENOG4105CE4 GlcNAc 6-P deacetylase C5I45_02960 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C5I45_02970 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C5I45_02975 ENOG4108S4C acetyltransferase C5I45_02985 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C5I45_02990 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C5I45_02995 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C5I45_03000 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C5I45_03005 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C5I45_03010 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C5I45_03015 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C5I45_03020 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C5I45_03025 ENOG4105BZ1 (ABC) transporter C5I45_03030 ENOG4105GIG C5I45_03035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5I45_03040 ENOG4105BZU Histidine kinase C5I45_03055 ENOG4105C3M thioredoxin reductase C5I45_03060 ENOG4108Z4K mutator MutT protein C5I45_03065 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C5I45_03070 ENOG4105CHW UPF0052 protein C5I45_03075 ENOG4105CIE May be required for sporulation (By similarity) C5I45_03080 ENOG4105KRI phosphocarrier protein (HPr C5I45_03085 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C5I45_03090 ENOG4105GGE ribonuclease C5I45_03095 ENOG4105C5I Dehydrogenase C5I45_03105 ENOG4108V2W Carbonate dehydratase C5I45_03110 ENOG4105CHH sulfate transporter C5I45_03115 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C5I45_03120 ENOG4108URH decarboxylase C5I45_03130 ENOG4105C7F AcnD-accessory protein PrpF C5I45_03135 ENOG4108KAM Transcriptional regulator C5I45_03140 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C5I45_03145 ENOG4105ETE Transcriptional regulator (LacI family C5I45_03150 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) C5I45_03155 ENOG4108HKT sucrose-6-phosphate hydrolase C5I45_03200 ENOG4105PY6 Phenolic acid decarboxylase C5I45_03205 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 C5I45_03215 ENOG4105NAE bifunctional deaminase-reductase domain protein C5I45_03225 ENOG4105EBR Carboxylesterase C5I45_03235 ENOG4105HTX biosynthesis protein C5I45_03240 ENOG4108QV3 biosynthesis protein C5I45_03250 ENOG4108PQP glycosyl transferase group 1 C5I45_03255 ENOG4105K64 Glycosyl transferase, family 2 C5I45_03260 ENOG4108KMV Glycosyl transferase (Group 1 C5I45_03265 ENOG41068W6 Capsular polysaccharide biosynthesis protein C5I45_03270 ENOG4107QRS glycosyltransferase group 2 family protein C5I45_03280 ENOG4105K64 Glycosyl transferase, family 2 C5I45_03290 ENOG4105D3Q Sugar transferase C5I45_03295 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family C5I45_03300 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5I45_03305 ENOG4108ZPC Polysaccharide pyruvyl transferase C5I45_03315 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5I45_03320 ENOG4105DAA L-lactate C5I45_03325 ENOG4105JXH GntR family transcriptional regulator C5I45_03330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5I45_03335 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C5I45_03340 ENOG4107QR9 Iron-sulfur cluster binding protein C5I45_03350 ENOG4105C6Z Gluconate C5I45_03355 ENOG4105CMG Carbohydrate kinase C5I45_03360 ENOG4106KNT transcriptional regulator C5I45_03370 ENOG4107RT3 EamA-like transporter family C5I45_03375 ENOG4105GZI Transcriptional regulator C5I45_03385 ENOG4105DEN Luciferase family C5I45_03390 ENOG4105CMD Transcriptional regulator, GntR family C5I45_03405 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C5I45_03415 ENOG4105BZA Phosphoglycerate kinase C5I45_03420 ENOG4105CP7 Triose-phosphate isomerase C5I45_03425 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C5I45_03430 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C5I45_03435 ENOG4105IIU Aminopeptidase C5I45_03440 ENOG4107QQG Dehydrogenase C5I45_03445 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5I45_03450 ENOG4108IAJ Nad-dependent epimerase dehydratase C5I45_03455 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5I45_03470 ENOG4105FJR Lmbe family C5I45_03485 ENOG4108W0I acetyltransferase C5I45_03490 ENOG4105T65 Membrane-associated protein C5I45_03505 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C5I45_03510 ENOG4107HG4 Transcriptional regulator C5I45_03515 ENOG4108IJ8 ABC transporter C5I45_03520 ENOG4105E90 ABC transporter C5I45_03525 ENOG4108HQR Glycine betaine C5I45_03530 ENOG4105R40 Glycine betaine carnitine choline C5I45_03535 ENOG4107HG4 Transcriptional regulator C5I45_03540 ENOG4108IJ8 ABC transporter C5I45_03545 ENOG4105E90 ABC transporter C5I45_03550 ENOG4108HQR Glycine betaine C5I45_03555 ENOG4105R40 Glycine betaine carnitine choline C5I45_03560 ENOG4105DA5 (ABC) transporter C5I45_03585 ENOG4105KVH Transcriptional regulator C5I45_03605 ENOG4105XZU Preprotein translocase, subunit SecG C5I45_03615 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C5I45_03620 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C5I45_03630 ENOG41067XF inhibitor C5I45_03635 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C5I45_03640 ENOG4108KSA LysR family transcriptional regulator C5I45_03645 ENOG4108XSB acetyltransferase, (GNAT) family C5I45_03670 ENOG4105CDA abc transporter atp-binding protein C5I45_03675 ENOG4105DEN Luciferase family C5I45_03715 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5I45_03720 ENOG4105D9R oxidoreductase C5I45_03725 ENOG4105VPX protein, conserved in bacteria C5I45_03730 ENOG410681U heavy metal transport detoxification protein C5I45_03735 ENOG4105C59 p-type ATPase C5I45_03740 ENOG4105C59 p-type ATPase C5I45_03745 ENOG4107ZQN disulfide bond C5I45_03760 ENOG4105EN6 Membrane C5I45_03765 ENOG4105EEM helicase C5I45_03770 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C5I45_03775 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C5I45_03785 ENOG4105EEQ Na H antiporter C5I45_03800 ENOG4108KYE ABC-2 type transporter C5I45_03810 ENOG4105CJ1 ABC, transporter C5I45_03815 ENOG4105BZU Histidine kinase C5I45_03820 ENOG4105WH1 Two component transcriptional regulator luxr family C5I45_03825 ENOG4105E0C molybdate abc transporter C5I45_03830 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C5I45_03835 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C5I45_03840 ENOG4107QZ2 Sulfatase C5I45_03845 ENOG4107K5X Membrane-bound metal-dependent hydrolase C5I45_03860 ENOG4105D5Q Arginine ornithine antiporter C5I45_03865 ENOG4105JQZ Methyltransferase C5I45_03875 ENOG4105DQ5 transport system permease protein C5I45_03880 ENOG4105EHG Permease protein C5I45_03885 ENOG4105E0A ABC, transporter C5I45_03895 ENOG4105F0F Oxalate decarboxylase C5I45_03905 ENOG4106DF4 Sigma-70, region 4 C5I45_03915 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5I45_03925 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C5I45_03930 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C5I45_03935 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C5I45_03940 ENOG4105EHG Permease protein C5I45_03945 ENOG4105E0A ABC, transporter C5I45_03950 ENOG4108WBT adenosyltransferase C5I45_03965 ENOG41087YS Phage shock protein A C5I45_03980 ENOG4105ENE Histidine kinase C5I45_03985 ENOG4105WH1 Two component transcriptional regulator luxr family C5I45_04010 ENOG4105C9Q fumarate hydratase class II C5I45_04015 ENOG41067SE Tetr family transcriptional regulator C5I45_04025 ENOG4105F3H Histidine kinase C5I45_04035 ENOG4105C0H protease C5I45_04040 ENOG4105HUF DNA protection during starvation protein C5I45_04045 ENOG4105E1F short-chain dehydrogenase reductase C5I45_04060 ENOG4105E0A ABC, transporter C5I45_04080 ENOG4105C5Q Transcriptional regulator C5I45_04085 ENOG4105C0R drug resistance transporter emrb qaca subfamily C5I45_04090 ENOG41067TZ transcriptional regulator, MarR family C5I45_04120 ENOG4105CHU acetyl-coa acetyltransferase C5I45_04125 ENOG4105C1G acyl-Coa dehydrogenase C5I45_04130 ENOG41080E8 Transcriptional regulator, Spx MgsR family C5I45_04135 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C5I45_04160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C5I45_04165 ENOG4108UMI ABC transporter, permease C5I45_04170 ENOG4105D01 (LipO)protein C5I45_04185 ENOG4105C3K feS assembly ATPase SufC C5I45_04190 ENOG4105JRK feS assembly protein SufD C5I45_04195 ENOG4105C9B Cysteine desulfurase C5I45_04200 ENOG4108UNV SUF system FeS assembly protein, NifU family C5I45_04205 ENOG4105DIW FeS assembly protein SUFB C5I45_04210 ENOG41083Q9 chitosanase C5I45_04220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C5I45_04225 ENOG4107VFR oxidoreductase C5I45_04230 ENOG4105PKS Excinuclease abc c subunit domain protein C5I45_04250 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C5I45_04255 ENOG4105XN3 extracellular solute-binding protein family 1 C5I45_04260 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C5I45_04265 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C5I45_04270 ENOG4108KPW sugar kinase C5I45_04275 ENOG4105FDP GntR family transcriptional regulator C5I45_04280 ENOG4108IJ9 (ABC) transporter C5I45_04285 ENOG4108K8S endonuclease I C5I45_04295 ENOG4105C5R Aminotransferase C5I45_04325 ENOG4105G9B Transcriptional regulator C5I45_04330 ENOG4105CD3 dihydroorotase C5I45_04340 ENOG4105I3N Conserved Protein C5I45_04350 ENOG4107R8B 5'-nucleotidase C5I45_04355 ENOG4108YTE sporulation protein YunB C5I45_04360 ENOG4105FAA peptidase M23 C5I45_04365 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C5I45_04375 ENOG4105MMD transcriptional regulator C5I45_04385 ENOG4105D4U had-superfamily hydrolase, subfamily iia C5I45_04390 ENOG4108W5N phosphatidylglycerophosphatase a C5I45_04400 ENOG4105D6E homoserine dehydrogenase C5I45_04405 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C5I45_04410 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C5I45_04415 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C5I45_04420 ENOG41083MR nifu domain-containing protein C5I45_04435 ENOG4105ZKE UPF0349 protein C5I45_04445 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C5I45_04450 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C5I45_04455 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C5I45_04480 ENOG4105CJ1 ABC, transporter C5I45_04495 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) C5I45_04510 ENOG4105CEP NADH dehydrogenase C5I45_04525 ENOG41069ER domain protein C5I45_04535 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C5I45_04555 ENOG4105NIV Esterase C5I45_04560 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C5I45_04565 ENOG4105E4F Isochorismate synthase C5I45_04570 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C5I45_04575 ENOG4105WQI isochorismatase C5I45_04580 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_04585 ENOG4105WQT MbtH domain protein C5I45_04595 ENOG4105DCF alanine dehydrogenase C5I45_04600 ENOG4108K8K Transcriptional regulator C5I45_04610 ENOG410904N short-chain dehydrogenase reductase C5I45_04625 ENOG4105C02 permease C5I45_04650 ENOG4105DAP Nicotinate phosphoribosyltransferase C5I45_04655 ENOG4105D58 Diguanylate phosphodiesterase C5I45_04680 ENOG4105BZU Histidine kinase C5I45_04690 ENOG4105KA0 thioesterase Superfamily protein C5I45_04695 ENOG4105KJM monovalent cation h antiporter subunit g C5I45_04705 ENOG4105SC1 monovalent cation H antiporter subunit E C5I45_04710 ENOG4108JPZ Monovalent cation H antiporter subunit D C5I45_04715 ENOG4108ZE9 Monovalent cation H antiporter subunit C C5I45_04720 ENOG4105HC0 Na H antiporter C5I45_04725 ENOG4105D65 subunit l C5I45_04740 ENOG4105UIB (ABC) transporter C5I45_04745 ENOG4108JQ9 ABC transporter C5I45_04750 ENOG4105DIH basic membrane C5I45_04755 ENOG4108MRH transcriptional regulatory protein C5I45_04770 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C5I45_04775 ENOG4105BZ4 penicillin-binding protein C5I45_04790 ENOG4105Y38 Kinase-associated protein B C5I45_04795 ENOG4108HGU Histidine kinase C5I45_04800 ENOG4105C87 Aminotransferase class I and II C5I45_04810 ENOG4108MUZ hydrolase C5I45_04815 ENOG4108ZB6 transcriptional regulator AsnC family C5I45_04820 ENOG4105CHM Aminotransferase C5I45_04830 ENOG4105WG9 Conserved Protein C5I45_04835 ENOG4107QW4 alcohol dehydrogenase C5I45_04850 ENOG4105CHJ isochorismatase hydrolase C5I45_04865 ENOG4107QYV phosphohexose isomerase C5I45_04880 ENOG4107PBV potassium channel C5I45_04885 ENOG4107PBV potassium channel C5I45_04900 ENOG4105C37 (CBS) domain C5I45_04910 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C5I45_04915 ENOG4105EA8 2-Nitropropane dioxygenase C5I45_04930 ENOG4105C8Q Methyl-accepting chemotaxis C5I45_04935 ENOG4105C8Q Methyl-accepting chemotaxis C5I45_04940 ENOG4105C8Q Methyl-accepting chemotaxis C5I45_04945 ENOG4105C8Q Methyl-accepting chemotaxis C5I45_04950 ENOG4108Z0Z intracellular protease Pfpi family C5I45_04955 ENOG4105EE0 oxidoreductase C5I45_04965 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C5I45_05015 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C5I45_05020 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C5I45_05035 ENOG4105TRT Transcriptional regulator C5I45_05040 ENOG4105C26 Dehydrogenase C5I45_05045 ENOG4108JB8 alcohol dehydrogenase C5I45_05050 ENOG4108VNY MOSC domain protein C5I45_05055 ENOG4106DF1 C5I45_05065 ENOG4105DZ6 Band 7 protein C5I45_05070 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C5I45_05205 ENOG4105E4F Isochorismate synthase C5I45_05210 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C5I45_05215 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C5I45_05220 ENOG4108IPT Naphthoate synthase C5I45_05225 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_05230 ENOG4105DTQ mandelate racemase muconate lactonizing C5I45_05255 ENOG4105NRA 50s ribosomal protein l31 type b C5I45_05260 ENOG4108V2W Carbonate dehydratase C5I45_05265 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C5I45_05270 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C5I45_05285 ENOG4108RMU ferritin dps family protein C5I45_05300 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C5I45_05310 ENOG4105D2X ABC transporter substrate-binding protein C5I45_05325 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C5I45_05330 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C5I45_05335 ENOG4105CAQ asparagine synthetase C5I45_05340 ENOG4105C85 amino acid C5I45_05345 ENOG4108Z0R Transferase C5I45_05350 ENOG4105E8V Alpha Beta Hydrolase Fold protein C5I45_05360 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C5I45_05375 ENOG4105N5T Radical SAM Protein C5I45_05395 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C5I45_05400 ENOG4105DVE abc transporter atp-binding protein C5I45_05420 ENOG4105C19 ABC transporter C5I45_05425 ENOG4107R34 abc transporter permease protein C5I45_05435 ENOG4105EWM Histidine kinase C5I45_05440 ENOG4105C19 ABC transporter C5I45_05455 ENOG410605W Major Facilitator C5I45_05460 ENOG4105BZU Histidine kinase C5I45_05470 ENOG4105C8T Leucyl-tRNA synthetase C5I45_05475 ENOG41085GJ domain protein C5I45_05490 ENOG4105I1K ABC transporter C5I45_05495 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component C5I45_05515 ENOG4105C94 Transporter C5I45_05520 ENOG4105CBX hi0933 family C5I45_05535 ENOG4105YW5 deoR family transcriptional regulator C5I45_05555 ENOG4105C7N Xanthine uracil vitamin C permease C5I45_05560 ENOG4107QSE Dipeptidase C5I45_05565 ENOG4105C6T cysteine synthase C5I45_05570 ENOG4107F58 2'-5' rna ligase C5I45_05585 ENOG4108V15 phosphotransferase enzyme family C5I45_05595 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C5I45_05600 ENOG4105C8F Beta-lactamase domain protein C5I45_05605 ENOG4105C6K Malic enzyme C5I45_05620 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C5I45_05635 ENOG4108VDD TRNA binding domain protein C5I45_05645 ENOG4105DFU Cell wall formation (By similarity) C5I45_05665 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C5I45_05670 ENOG4105ETE Transcriptional regulator (LacI family C5I45_05675 ENOG4107R0U MotA TolQ exbB proton channel C5I45_05680 ENOG4105ER2 Ompa motb domain protein C5I45_05685 ENOG4105DGU Histone deacetylase C5I45_05690 ENOG4105W87 Cbs domain C5I45_05695 ENOG4105F1V Acetoin utilization protein C5I45_05710 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C5I45_05725 ENOG4108NGU Transcriptional regulator C5I45_05755 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C5I45_05800 ENOG4105C26 Dehydrogenase C5I45_05805 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C5I45_05815 ENOG4105BZU Histidine kinase C5I45_05825 ENOG4105U5Y Transcriptional regulator C5I45_05850 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C5I45_05860 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C5I45_05865 ENOG4105EFZ amidohydrolase C5I45_05870 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C5I45_05875 ENOG4105D07 Signal peptide peptidase, SppA C5I45_05880 ENOG4105VK3 rdd domain containing protein C5I45_05890 ENOG4105KBJ sporulation protein ytfj C5I45_05895 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C5I45_05905 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C5I45_05910 ENOG4105EPU Molybdenum cofactor synthesis domain protein C5I45_05915 ENOG4105CDH Citrulline--aspartate ligase C5I45_05920 ENOG4105CH7 arginosuccinase C5I45_05930 ENOG4105E8R UPF0173 metal-dependent hydrolase C5I45_05945 ENOG4105SFS phosphoesterase RecJ domain protein C5I45_05950 ENOG4106EVM C5I45_05960 ENOG4105VV2 C5I45_05965 ENOG4105C0B DNA polymerase III (alpha subunit) C5I45_05970 ENOG4105C6K Malic enzyme C5I45_05975 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C5I45_05980 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C5I45_05985 ENOG4105CTQ phosphohexokinase C5I45_05990 ENOG4105CA9 Pyruvate kinase C5I45_05995 ENOG4105FS0 cytoplasmic membrane protein C5I45_06000 ENOG4108REF Sporulation integral membrane protein ytvi C5I45_06015 ENOG4105G7B Protein of unknown function (DUF2992) C5I45_06035 ENOG4105BZN citrate synthase C5I45_06040 ENOG4108HMX isocitrate dehydrogenase (NADP) C5I45_06050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5I45_06055 ENOG4105BZU Histidine kinase C5I45_06060 ENOG4105C2M dna polymerase I C5I45_06065 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C5I45_06075 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C5I45_06080 ENOG4105CV8 reductase C5I45_06085 ENOG4105F27 Major Facilitator C5I45_06090 ENOG4105KVH Transcriptional regulator C5I45_06095 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C5I45_06100 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C5I45_06125 ENOG4108TDW sporulation protein YtxC C5I45_06130 ENOG4105C22 threonyL-tRNA synthetase C5I45_06135 ENOG4105U0R haloacid dehalogenase-like hydrolase C5I45_06140 ENOG4108HRK Histidine kinase C5I45_06145 ENOG4105DY9 regulatoR C5I45_06155 ENOG41067MG lrgb family C5I45_06160 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C5I45_06165 ENOG4105VJV 50s ribosomal protein L35 C5I45_06170 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C5I45_06175 ENOG410696E Membrane C5I45_06185 ENOG4105CN9 Peptidase m42 family protein C5I45_06190 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase C5I45_06200 ENOG4105EF1 ribulokinase C5I45_06205 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase C5I45_06215 ENOG4108MDK Dehydrogenase C5I45_06230 ENOG4105DRS transport system, permease C5I45_06235 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C5I45_06245 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C5I45_06250 ENOG4105CQB FAD linked oxidase domain protein C5I45_06260 ENOG41067MF small acid-soluble spore protein C5I45_06265 ENOG4108RWN rrna methyltransferase C5I45_06270 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C5I45_06275 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C5I45_06280 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5I45_06295 ENOG4105DCG PHP domain protein C5I45_06300 ENOG4105C98 muts2 protein C5I45_06315 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_06320 ENOG4107Z3H Transcriptional regulator, TetR family C5I45_06325 ENOG41060WC Enoyl-CoA hydratase C5I45_06330 ENOG4105BZJ Electron transfer flavoprotein C5I45_06335 ENOG4105C10 Electron transfer flavoprotein C5I45_06340 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C5I45_06345 ENOG4105K63 Thioredoxin C5I45_06350 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C5I45_06360 ENOG4105CFH Aspartokinase C5I45_06370 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C5I45_06380 ENOG4105E33 succinate dehydrogenase C5I45_06390 ENOG4105PFC Transcriptional regulator C5I45_06395 ENOG41067TZ transcriptional regulator, MarR family C5I45_06400 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C5I45_06405 ENOG4108XJQ germination protein C5I45_06410 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C5I45_06415 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C5I45_06420 ENOG4105M59 Phosphodiesterase, mj0936 family C5I45_06440 ENOG4107SCJ type I restriction enzyme EcoKI subunit R C5I45_06485 ENOG4105C7K acetolactate synthase C5I45_06490 ENOG4108ZP8 Acetolactate synthase small subunit C5I45_06495 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C5I45_06505 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5I45_06510 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C5I45_06515 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C5I45_06525 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C5I45_06530 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C5I45_06535 ENOG4108IUQ atp-dependent protease C5I45_06540 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C5I45_06545 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C5I45_06555 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C5I45_06565 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C5I45_06575 ENOG4105D52 delta-aminolevulinic acid dehydratase C5I45_06580 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C5I45_06585 ENOG41068KH stage VI sporulation protein D C5I45_06590 ENOG4106AR7 Spore coat protein C5I45_06600 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C5I45_06605 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C5I45_06610 ENOG4106A3R peptidase C5I45_06620 ENOG4108Z03 MAF-like protein C5I45_06625 ENOG4105W5Q DNA repair protein (RadC C5I45_06630 ENOG4105DFF Rod shape-determining protein mreb C5I45_06635 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C5I45_06640 ENOG4105YHC Rod shape-determining protein MreD C5I45_06645 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C5I45_06650 ENOG4107QMS site-determining protein C5I45_06665 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C5I45_06670 ENOG4105X36 (ribosomal) protein C5I45_06675 ENOG4105K46 50S ribosomal protein l27 C5I45_06685 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C5I45_06695 ENOG4105CQC Prephenate dehydratase C5I45_06710 ENOG4108IYU L-aspartate oxidase C5I45_06715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C5I45_06720 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C5I45_06725 ENOG4106678 morphogenetic protein associated with SpoVID C5I45_06745 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C5I45_06750 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C5I45_06755 ENOG41061AI Protein of unknown function (DUF2905) C5I45_06760 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C5I45_06765 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C5I45_06770 ENOG4105VIE preprotein translocase, subunit YajC C5I45_06775 ENOG4105NAP C5I45_06780 ENOG4108QG2 Membrane C5I45_06785 ENOG4105CKP Polysaccharide Biosynthesis Protein C5I45_06795 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C5I45_06800 ENOG4105NCW Trka-c domain protein C5I45_06805 ENOG41067VP Protein of unknown function (DUF1049) C5I45_06810 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C5I45_06820 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C5I45_06825 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C5I45_06830 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C5I45_06835 ENOG4105CUT histidyl-tRNA synthetase C5I45_06840 ENOG4105C9M aspartyl-trna synthetase C5I45_06850 ENOG4105CUZ uba thif-type nad fad binding protein C5I45_06855 ENOG4105D1H recombination factor protein RarA C5I45_06865 ENOG4105C3J Cysteine desulfurase C5I45_06870 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C5I45_06880 ENOG4105C7H Helicase, RecD TraA family C5I45_06890 ENOG41060CR C5I45_06900 ENOG4105DRP amino acid AbC transporter C5I45_06905 ENOG4105EAD ABC transporter C5I45_06910 ENOG4105CT1 (ABC) transporter C5I45_06915 ENOG4105CDA abc transporter atp-binding protein C5I45_06920 ENOG4105C02 permease C5I45_06925 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C5I45_06930 ENOG4105VBH UPF0297 protein C5I45_06935 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C5I45_06945 ENOG4105HHA aminodeoxychorismate lyase C5I45_06950 ENOG4108VQJ O-methyltransferase C5I45_06955 ENOG4105XYU peptidase (U32 family) C5I45_06960 ENOG4105CFP Peptidase U32 C5I45_06970 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C5I45_06975 ENOG4107XRG penicillin-binding protein C5I45_07005 ENOG4105C28 cystathionine C5I45_07020 ENOG4108JB9 formate dehydrogenase C5I45_07025 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C5I45_07030 ENOG4105TMB Formate nitrite transporter C5I45_07050 ENOG41082JN Transcriptional regulator C5I45_07055 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C5I45_07060 ENOG4105D94 Major Facilitator Superfamily C5I45_07065 ENOG4107RSM transcriptional regulator C5I45_07070 ENOG4108Z66 YbaK ebsC protein C5I45_07085 ENOG4105DM4 PTS System C5I45_07090 ENOG4105DG6 mannose-6-phosphate isomerase C5I45_07100 ENOG4108HCJ Hydrolase C5I45_07105 ENOG4105DQF Hydrolase C5I45_07120 ENOG4108U7W acetyltransferase C5I45_07125 ENOG4108J8C transporter major facilitator family protein C5I45_07135 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C5I45_07145 ENOG41086D8 Transcriptional regulator C5I45_07160 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5I45_07175 ENOG41080BT SNARE associated Golgi C5I45_07195 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C5I45_07200 ENOG4105CQW ribosome biogenesis GTPase YqeH C5I45_07205 ENOG4105E2X shikimate dehydrogenase C5I45_07210 ENOG410812S Rna-binding protein C5I45_07215 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C5I45_07220 ENOG4108WF2 Metal Dependent Phosphohydrolase C5I45_07230 ENOG4108D32 Methyltransferase C5I45_07240 ENOG4105KQC Competence protein C5I45_07245 ENOG4108UK2 deaminase C5I45_07250 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C5I45_07260 ENOG4105TQK DNA polymerase iii, delta' subunit C5I45_07265 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) C5I45_07270 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) C5I45_07275 ENOG4108ZRV stage ii sporulation protein p C5I45_07285 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C5I45_07290 ENOG4105CSA Coproporphyrinogen iii oxidase C5I45_07295 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C5I45_07300 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C5I45_07305 ENOG4105CFG Acts as a chaperone (By similarity) C5I45_07310 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C5I45_07315 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C5I45_07320 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C5I45_07325 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C5I45_07340 ENOG4105KTH gatB Yqey C5I45_07345 ENOG4105F7J membrane-bound serine protease C5I45_07350 ENOG4105DI5 UPF0365 protein C5I45_07360 ENOG41068P3 sporulation protein YqfC C5I45_07365 ENOG4105EI1 sporulation protein yqfd C5I45_07370 ENOG4105C9A Phoh family C5I45_07375 ENOG4105CTJ Metal Dependent Phosphohydrolase C5I45_07380 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C5I45_07385 ENOG4107YR5 Diacylglycerol kinase C5I45_07390 ENOG4105KG3 cytidine deaminase C5I45_07395 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C5I45_07405 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) C5I45_07410 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C5I45_07415 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C5I45_07425 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C5I45_07430 ENOG4108UPT UPF0178 protein C5I45_07435 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C5I45_07440 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5I45_07455 ENOG4105EGD dinuclear metal center protein, YbgI family C5I45_07460 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C5I45_07475 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C5I45_07480 ENOG41069ZM Protein of unknown function (DUF2624) C5I45_07485 ENOG4108JYZ YitT family C5I45_07490 ENOG4105N80 Ferric uptake regulator, Fur family C5I45_07495 ENOG4108U5J '-nucleotidase C5I45_07500 ENOG41063Y9 C5I45_07505 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C5I45_07520 ENOG4105SXS Protein of unknown function (DUF456) C5I45_07525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C5I45_07535 ENOG4107RF6 penicillin-binding protein C5I45_07540 ENOG4105CVA phosphate C5I45_07545 ENOG4105C8U phosphate abc transporter C5I45_07550 ENOG4105E2Z phosphate ABC transporter (Permease C5I45_07555 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C5I45_07560 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C5I45_07565 ENOG41068DG YceG-like family C5I45_07575 ENOG4105WDJ 50S ribosomal protein L33 C5I45_07580 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C5I45_07625 ENOG4105C5X domain protein C5I45_07650 ENOG4105C37 (CBS) domain C5I45_07710 ENOG4105VFR signal peptidase C5I45_07720 ENOG4108IMY Transcriptional regulator C5I45_07735 ENOG4105C0D helicase C5I45_07740 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C5I45_07750 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C5I45_07755 ENOG4105WZW rhodanese family C5I45_07760 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C5I45_07780 ENOG4105CBJ Metal-dependent enzyme C5I45_07790 ENOG4105DC7 peptidase M24 C5I45_07795 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C5I45_07805 ENOG4105CD2 stage iii sporulation protein aa C5I45_07810 ENOG4105KR5 Stage iii sporulation protein C5I45_07815 ENOG4108CQH stage III sporulation protein AC C5I45_07820 ENOG4105KQ4 Stage iii sporulation protein ad C5I45_07830 ENOG410644B Stage III sporulation protein af C5I45_07850 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C5I45_07855 ENOG4108ZSR alkaline shock protein C5I45_07860 ENOG4105M7K Involved in the transcription termination process (By similarity) C5I45_07865 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C5I45_07870 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C5I45_07875 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C5I45_07880 ENOG4105CTB Polyprenyl synthetase C5I45_07885 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C5I45_07890 ENOG4105DX0 Hemolysin A C5I45_07895 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C5I45_07900 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C5I45_07905 ENOG4105S1Z Stage IV sporulation protein B C5I45_07910 ENOG4107QQR Sporulation C5I45_07920 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C5I45_07935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5I45_07955 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C5I45_07960 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5I45_07970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C5I45_07975 ENOG4105C1G acyl-Coa dehydrogenase C5I45_07985 ENOG4105DXD 2-methylcitrate dehydratase C5I45_07990 ENOG4105CR4 methylisocitrate lyase C5I45_07995 ENOG4106CCJ Protein of unknown function (DUF2627) C5I45_08000 ENOG4108JUB Transcriptional regulator C5I45_08010 ENOG4107RDP Dehydrogenase C5I45_08015 ENOG4105CKM Branched-chain carboxylic acid kinase C5I45_08030 ENOG4105CPP Dehydrogenase, E1 component C5I45_08035 ENOG4105C7S Dehydrogenase C5I45_08040 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C5I45_08045 ENOG4108Y6J UPF0403 protein C5I45_08050 ENOG4108HW3 (ABC) transporter C5I45_08055 ENOG4105E5Q amino acid AbC transporter C5I45_08060 ENOG4105CDA abc transporter atp-binding protein C5I45_08065 ENOG4108QEG Membrane C5I45_08070 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C5I45_08075 ENOG4108ZVT methylmalonyl-coA epimerase C5I45_08080 ENOG4108HNZ carboxyl transferase C5I45_08085 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C5I45_08090 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) C5I45_08100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5I45_08105 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C5I45_08110 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C5I45_08115 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C5I45_08120 ENOG410861F 50S ribosomal protein L33 C5I45_08130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5I45_08140 ENOG4108K70 Transcriptional regulator C5I45_08150 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C5I45_08160 ENOG4107QKG PfaD family C5I45_08175 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_08180 ENOG4105CHR reductase C5I45_08190 ENOG4105C0W non-ribosomal peptide synthetase C5I45_08200 ENOG4105C0W non-ribosomal peptide synthetase C5I45_08205 ENOG4105C0W non-ribosomal peptide synthetase C5I45_08220 ENOG4106A3M Cytochrome p-450 C5I45_08225 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C5I45_08230 ENOG4108KQ6 Enoyl-CoA hydratase C5I45_08235 ENOG4105II7 pyrroline-5-carboxylate reductase C5I45_08240 ENOG41069FQ Metallo-beta-lactamase superfamily C5I45_08245 ENOG4108IXY short-chain dehydrogenase reductase C5I45_08255 ENOG4105CS9 pantothenic acid kinase C5I45_08260 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C5I45_08270 ENOG4105C02 permease C5I45_08285 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5I45_08290 ENOG4108XET gCN5-related N-acetyltransferase C5I45_08295 ENOG4105KAC Antibiotic biosynthesis monooxygenase C5I45_08300 ENOG4105RHY Pfam:UPF0157 C5I45_08305 ENOG4106HZJ C5I45_08325 ENOG4105CPC Aldo Keto reductase C5I45_08335 ENOG4108YZ4 nudix hydrolase C5I45_08345 ENOG4108IMY Transcriptional regulator C5I45_08350 ENOG4105HDK L-asparaginase C5I45_08355 ENOG4108IJ0 Aspartate ammonia-lyase C5I45_08360 ENOG4105DFD Na H antiporter C5I45_08380 ENOG4105MZ9 stage II sporulation protein m C5I45_08385 ENOG4105I3K Ferric uptake regulator, Fur family C5I45_08395 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5I45_08400 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C5I45_08405 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) C5I45_08410 ENOG4105DZ1 carboxypeptidase C5I45_08415 ENOG41082AN stage II sporulation protein C5I45_08420 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C5I45_08425 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5I45_08440 ENOG41090VF Stage v sporulation protein ac C5I45_08445 ENOG4105CZ3 stage V sporulation protein ad C5I45_08455 ENOG4105G6R Stage v sporulation protein ae C5I45_08465 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C5I45_08470 ENOG4105PTM secreted protein C5I45_08475 ENOG4107ZE5 PPIases accelerate the folding of proteins C5I45_08500 ENOG4108R6K riboflavin synthase, subunit alpha C5I45_08505 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5I45_08510 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C5I45_08535 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C5I45_08540 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C5I45_08550 ENOG4105DZ1 carboxypeptidase C5I45_08555 ENOG4108JIC nucleoside recognition domain protein C5I45_08565 ENOG4105FE9 pseudouridine synthase C5I45_08575 ENOG4107TWT Cytochrome c biogenesis protein C5I45_08580 ENOG4105CRE cytochrome C C5I45_08585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5I45_08590 ENOG4105BZU Histidine kinase C5I45_08605 ENOG4108JQ1 Dehydrogenase C5I45_08610 ENOG4108SAX Membrane C5I45_08620 ENOG4105T7X C5I45_08625 ENOG4105C9U ATP-dependent DNA helicase RecQ C5I45_08630 ENOG4105I7S Abortive infection protein C5I45_08645 ENOG4107RGJ metallophosphoesterase C5I45_08660 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C5I45_08665 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) C5I45_08675 ENOG4105MSI germination protein ypeb C5I45_08685 ENOG4105CAT Cytidine monophosphate kinase C5I45_08690 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C5I45_08710 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C5I45_08715 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C5I45_08730 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C5I45_08735 ENOG4105K70 DNA-binding protein C5I45_08740 ENOG4105EUJ GTP cyclohydrolase i C5I45_08745 ENOG4105WP2 Tryptophan RNA-binding attenuator protein C5I45_08750 ENOG4105XXQ heptaprenyl diphosphate synthase component I C5I45_08755 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C5I45_08760 ENOG4105EAH synthase C5I45_08765 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C5I45_08770 ENOG4105BZU Histidine kinase C5I45_08775 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C5I45_08785 ENOG4105KHN chorismate mutase C5I45_08790 ENOG4105CRQ synthase (Component I) C5I45_08800 ENOG4105DK0 Indole-3-glycerol phosphate synthase C5I45_08805 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C5I45_08810 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C5I45_08820 ENOG4105CIH Imidazole acetol-phosphate transaminase C5I45_08830 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C5I45_08835 ENOG41068YB TPR repeat-containing protein C5I45_08855 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C5I45_08875 ENOG4105F0F Oxalate decarboxylase C5I45_08880 ENOG4108JYZ YitT family C5I45_08885 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C5I45_08890 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C5I45_08895 ENOG4108Z5K methylglyoxal synthase C5I45_08900 ENOG4105FJR Lmbe family C5I45_08905 ENOG4105CPK Glycosyl transferase (Group 1 C5I45_08910 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C5I45_08920 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C5I45_08930 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C5I45_08935 ENOG4105DVT helicase C5I45_08940 ENOG4105YAC C5I45_08950 ENOG4105CHM Aminotransferase C5I45_08955 ENOG4105C5S asparaginyl-tRNA synthetase C5I45_08965 ENOG4105CSM endonuclease III C5I45_08975 ENOG4105BZ4 penicillin-binding protein C5I45_08980 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) C5I45_09025 ENOG4108I5C dEAD DEAH box helicase C5I45_09030 ENOG4107X2U Inherit from COG: Exonuclease-like protein C5I45_09040 ENOG4108UKS UPF0398 protein C5I45_09045 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) C5I45_09055 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C5I45_09070 ENOG4105DVT helicase C5I45_09075 ENOG4105CTD carboxy-peptidase C5I45_09080 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C5I45_09085 ENOG4105C2W permease C5I45_09120 ENOG41065KQ synthase C5I45_09135 ENOG410890F Dynamin family C5I45_09160 ENOG41081VK Ribonuclease C5I45_09200 ENOG4105CVG Homoserine O-transsuccinylase C5I45_09205 ENOG4108V06 Glutathione peroxidase C5I45_09220 ENOG4105C01 Dihydroxy-acid dehydratase C5I45_09225 ENOG4108Y6J UPF0403 protein C5I45_09230 ENOG4107YX5 Pfam:DUF548 C5I45_09240 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C5I45_09245 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C5I45_09255 ENOG4108UT2 hemolysin iii C5I45_09265 ENOG4105C7B Threonine dehydratase C5I45_09275 ENOG4108KF3 Electron transport protein SCO1 SenC C5I45_09280 ENOG41090WU lipolytic protein G-D-S-L family C5I45_09285 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) C5I45_09295 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C5I45_09300 ENOG4105E0X reductase C5I45_09330 ENOG4107Y9E nuclease C5I45_09340 ENOG4106BHF C5I45_09345 ENOG4106ANW SMI1_KNR4 C5I45_09405 ENOG4108J9Q DNA ligase C5I45_09485 ENOG4105FTQ Dna gyrase C5I45_09490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C5I45_09505 ENOG4107S4Y M20 DapE family protein YgeY C5I45_09510 ENOG4108TSC N-acetyltransferase C5I45_09515 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C5I45_09550 ENOG410841Q phosphoesterase PA-phosphatase related protein C5I45_09555 ENOG4106Z5R C5I45_09565 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C5I45_09570 ENOG4108VXD carboxy-peptidase C5I45_09590 ENOG4108S3Y transcriptional regulator C5I45_09595 ENOG4105CS2 ec 3.2.1.21 C5I45_09605 ENOG4105E1V na solute symporter C5I45_09620 ENOG4105FBA Phospholipase Carboxylesterase C5I45_09640 ENOG41090U3 tautomerase C5I45_09655 ENOG4105FR1 rard protein C5I45_09675 ENOG4106SCS STAS domain C5I45_09680 ENOG4107QMU Mate efflux family protein C5I45_09690 ENOG41087PP glycosyltransferase MGT family C5I45_09695 ENOG4105K4H Nlp p60 protein C5I45_09705 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C5I45_09710 ENOG4107T89 von Willebrand factor, type A C5I45_09715 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C5I45_09720 ENOG4105C7S Dehydrogenase C5I45_09730 ENOG4105C09 Bile acid C5I45_09735 ENOG4105C8J )-transporter C5I45_09740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C5I45_09745 ENOG4105EWU Squalene--hopene cyclase C5I45_09750 ENOG4105C26 Dehydrogenase C5I45_09795 ENOG4105SCY DNAK suppressor C5I45_09800 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5I45_09810 ENOG4105C9U ATP-dependent DNA helicase RecQ C5I45_09815 ENOG41069ER domain protein C5I45_09840 ENOG4108SJC Membrane C5I45_09850 ENOG4105KTU Transcriptional regulator, arsr family C5I45_09860 ENOG4108W8B Beta-lactamase domain protein C5I45_09870 ENOG4105FTV AraC Family Transcriptional Regulator C5I45_09875 ENOG4108Z7R Chaperone CsaA C5I45_09885 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C5I45_09920 ENOG4105E18 UPF0276 protein C5I45_10005 ENOG4108J2R molybdopterin oxidoreductase C5I45_10010 ENOG4108M3J Dehydrogenase C5I45_10015 ENOG4107U6E carbohydrate kinase FGGY C5I45_10020 ENOG4105IE8 Alpha-ketoglutarate permease C5I45_10025 ENOG4108UB7 C5I45_10050 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C5I45_10055 ENOG4105C5Q Transcriptional regulator C5I45_10060 ENOG4105CBC glutamate synthase C5I45_10065 ENOG4105BZ8 glutamate synthase C5I45_10075 ENOG4105CB2 alcohol dehydrogenase C5I45_10080 ENOG4108KSA LysR family transcriptional regulator C5I45_10085 ENOG4105C22 threonyL-tRNA synthetase C5I45_10090 ENOG4105WAB arsR family transcriptional regulator C5I45_10095 ENOG4108RWP Major Facilitator Superfamily protein C5I45_10100 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C5I45_10125 ENOG4107QJQ Mate efflux family protein C5I45_10130 ENOG4108N2V aldose 1-epimerase C5I45_10135 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C5I45_10160 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_10170 ENOG4106U2H Protein of unknown function (DUF1360) C5I45_10175 ENOG4105F32 YngK protein C5I45_10180 ENOG4105C1G acyl-Coa dehydrogenase C5I45_10185 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_10190 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C5I45_10195 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C5I45_10200 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C5I45_10205 ENOG4105E39 Enoyl-CoA hydratase C5I45_10210 ENOG4107QX3 carboxylase C5I45_10215 ENOG4107T5V SNARE associated Golgi C5I45_10220 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C5I45_10230 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) C5I45_10235 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C5I45_10240 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C5I45_10245 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C5I45_10250 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C5I45_10255 ENOG4106A3M Cytochrome p-450 C5I45_10260 ENOG4105CY2 Citrate transporter C5I45_10265 ENOG4105D6N CoA-transferase, subunit a C5I45_10270 ENOG4108IIH CoA-transferase subunit B C5I45_10275 ENOG4105DTD Dehydrogenase C5I45_10305 ENOG4107SYN Glycosyl hydrolases family 43 C5I45_10315 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5I45_10355 ENOG4105FVX C5I45_10370 ENOG4108I5G Major Facilitator superfamily C5I45_10380 ENOG4105DMW Dehydrogenase reductase C5I45_10385 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C5I45_10390 ENOG4108UHU Aldolase C5I45_10395 ENOG4105CPQ Dehydrogenase C5I45_10420 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5I45_10425 ENOG4105K4P CoA-binding domain protein C5I45_10430 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C5I45_10435 ENOG4105W8X HesB YadR YfhF-family protein C5I45_10440 ENOG4105MI2 C5I45_10450 ENOG41067CD Small, acid-soluble spore protein Tlp C5I45_10465 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5I45_10470 ENOG4108I0Z Aconitate hydratase C5I45_10505 ENOG4107QIV Cytochrome c biogenesis protein C5I45_10515 ENOG4105VXM UPF0154 protein C5I45_10525 ENOG4105CV1 Transketolase (EC 2.2.1.1) C5I45_10530 ENOG4105VPS UPF0291 protein C5I45_10535 ENOG4108SVB resolvase C5I45_10545 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C5I45_10565 ENOG4105K7W phage-related replication protein C5I45_10570 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C5I45_10595 ENOG41068WN C5I45_10605 ENOG4108M1A Chitin-binding protein C5I45_10655 ENOG4105DQ4 alcohol dehydrogenase C5I45_10665 ENOG4105D29 Helix-turn-helix type 11 domain protein C5I45_10685 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C5I45_10690 ENOG4105CMG Carbohydrate kinase C5I45_10695 ENOG4105C93 Xylose Isomerase C5I45_10705 ENOG4105DSG hydrolase family 43 C5I45_10710 ENOG4105CT4 transporter C5I45_10735 ENOG41064BW Protein of unknown function (DUF2568) C5I45_10760 ENOG4105C5F glutamine synthetase C5I45_10765 ENOG4105KV4 Transcriptional regulator C5I45_10770 ENOG4105CXI aluminum resistance protein C5I45_10775 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C5I45_10780 ENOG4106F1P AAA ATPase, central domain protein C5I45_10790 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C5I45_10795 ENOG4105U6W MutT NUDIX family protein C5I45_10800 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C5I45_10805 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C5I45_10830 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C5I45_10855 ENOG4108X3M OsmC Ohr family protein C5I45_10860 ENOG4105K7W phage-related replication protein C5I45_10870 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C5I45_10880 ENOG4105XPP Protein of unknown function (DUF1275) C5I45_10885 ENOG4105WFK nuclease C5I45_10890 ENOG4106A3M Cytochrome p-450 C5I45_10900 ENOG4105C0W non-ribosomal peptide synthetase C5I45_10910 ENOG4107SQU synthase C5I45_10915 ENOG4105C0W non-ribosomal peptide synthetase C5I45_10920 ENOG4108KQ6 Enoyl-CoA hydratase C5I45_10925 ENOG4108MGH Enoyl-CoA hydratase C5I45_10930 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C5I45_10935 ENOG41062T2 Acyl carrier protein C5I45_10940 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C5I45_10945 ENOG4108JA1 polyketide synthase C5I45_10950 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C5I45_10955 ENOG4108151 Beta-lactamase domain protein C5I45_10970 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C5I45_10990 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C5I45_10995 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C5I45_11000 ENOG4105CPQ Dehydrogenase C5I45_11005 ENOG4105MCT stage V sporulation protein S C5I45_11010 ENOG4105D48 metallophosphoesterase C5I45_11020 ENOG4108A04 Beta-lactamase C5I45_11025 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C5I45_11030 ENOG4105CEV competence damage-inducible protein C5I45_11035 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C5I45_11050 ENOG4105XZV Protein of unknown function (DUF3243) C5I45_11055 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C5I45_11070 ENOG4105EYF MMPL domain protein C5I45_11085 ENOG4105FDP GntR family transcriptional regulator C5I45_11090 ENOG4105CNU cell division protein FtsK C5I45_11100 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C5I45_11110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5I45_11120 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C5I45_11125 ENOG4108S0H Dipicolinic acid synthetase, b subunit C5I45_11130 ENOG4105E35 Dipicolinate synthase subunit A C5I45_11140 ENOG4105C1V Peptidase, M16 C5I45_11150 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C5I45_11155 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C5I45_11160 ENOG4105DTN riboflavin biosynthesis protein ribF C5I45_11165 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C5I45_11170 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C5I45_11175 ENOG4105W7A Protein of unknown function (DUF503) C5I45_11180 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C5I45_11185 ENOG4105VHM ribosomal protein C5I45_11190 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C5I45_11195 ENOG4105CHV Transcription elongation factor NusA C5I45_11200 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C5I45_11205 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C5I45_11210 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C5I45_11215 ENOG4105DZP Membrane-associated zinc metalloprotease C5I45_11225 ENOG4105KNE Phosphatidate cytidylyltransferase C5I45_11230 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C5I45_11235 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C5I45_11240 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C5I45_11250 ENOG4105CE9 30S ribosomal protein S2 C5I45_11260 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5I45_11265 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) C5I45_11275 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C5I45_11280 ENOG4105CBS Chea signal transduction histidine kinase C5I45_11285 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C5I45_11295 ENOG4105FZW flagellar biosynthesis regulator FlhF C5I45_11300 ENOG4105D7B Flagellar biosynthesis protein flha C5I45_11305 ENOG4105D00 flagellar biosynthetic protein flhB C5I45_11310 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C5I45_11315 ENOG4105VS8 Flagellar biosynthetic protein fliq C5I45_11320 ENOG4105CN7 Flagellar biosynthetic protein FliP C5I45_11330 ENOG4107YTP response regulator receiver protein C5I45_11335 ENOG4105DD5 Flagellar motor switch protein C5I45_11340 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C5I45_11350 ENOG41068WV flagellar FlbD family protein C5I45_11355 ENOG4108JQA flagellar C5I45_11360 ENOG410822I Flagellar hook capping protein C5I45_11365 ENOG410696Y Flagellar hook-length control protein C5I45_11375 ENOG4106YF4 Flagellar biosynthesis chaperone C5I45_11390 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C5I45_11395 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C5I45_11400 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C5I45_11405 ENOG4108ZC9 flagellar basal-body rod protein flgc C5I45_11410 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C5I45_11420 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C5I45_11425 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C5I45_11430 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5I45_11435 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C5I45_11440 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C5I45_11445 ENOG4105C79 DNA protecting protein DprA C5I45_11450 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C5I45_11455 ENOG4105CMV Succinyl-CoA synthetase subunit beta C5I45_11460 ENOG4105VM1 flagellar C5I45_11470 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5I45_11475 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C5I45_11480 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C5I45_11485 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C5I45_11500 ENOG4108BW8 UPF0109 protein C5I45_11505 ENOG4105K5M 30s ribosomal protein S16 C5I45_11515 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C5I45_11525 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C5I45_11530 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C5I45_11535 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C5I45_11540 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C5I45_11545 ENOG4105CHR reductase C5I45_11550 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C5I45_11555 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C5I45_11560 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C5I45_11565 ENOG4105CB5 ATP-dependent DNA helicase recG C5I45_11570 ENOG4105EJQ L-serine dehydratase C5I45_11580 ENOG4105DP4 dak2 domain fusion protein ylov C5I45_11585 ENOG4108ZAA Alkaline-shock protein C5I45_11590 ENOG4105VB9 50S ribosomal protein l28 C5I45_11600 ENOG4105FJ0 thiamine C5I45_11605 ENOG4105DJV ribulose-phosphate 3-epimerase C5I45_11610 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C5I45_11615 ENOG4105D9P serine threonine protein kinase C5I45_11620 ENOG4108ZF3 Phosphatase C5I45_11625 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C5I45_11630 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C5I45_11635 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C5I45_11640 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C5I45_11645 ENOG4105C25 Primosomal protein n' C5I45_11650 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C5I45_11660 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C5I45_11665 ENOG4105KC4 UPF0296 protein C5I45_11670 ENOG4105DSJ YicC domain protein C5I45_11680 ENOG4105F23 Fibronectin-binding protein C5I45_11690 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C5I45_11695 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C5I45_11700 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C5I45_11710 ENOG4107RIQ Sulfate adenylate transferase C5I45_11725 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C5I45_11730 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C5I45_11735 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) C5I45_11740 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C5I45_11745 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C5I45_11750 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C5I45_11760 ENOG4105CXT aspartate transcarbamylase C5I45_11770 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C5I45_11775 ENOG4105C34 Pseudouridine synthase C5I45_11780 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C5I45_11790 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C5I45_11805 ENOG4105DBK s4 domain protein C5I45_11810 ENOG41067XK integral membrane protein C5I45_11815 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C5I45_11820 ENOG4105DFA alanine racemase domain protein C5I45_11825 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C5I45_11830 ENOG4105WR5 sporulation protein, YlmC YmxH family C5I45_11840 ENOG4105DKW ABC transporter C5I45_11850 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5I45_11855 ENOG4105FFI sigma-e processing peptidase spoiiga C5I45_11865 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C5I45_11870 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C5I45_11875 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C5I45_11880 ENOG4105D4A Cell wall formation (By similarity) C5I45_11885 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C5I45_11890 ENOG4105CNI cell division protein FtsW C5I45_11895 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C5I45_11900 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C5I45_11905 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C5I45_11910 ENOG4105CJN penicillin-binding protein C5I45_11915 ENOG4105CJN penicillin-binding protein C5I45_11925 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C5I45_11930 ENOG4108V6E Cell division protein mraZ C5I45_11955 ENOG41067VY 50S ribosomal protein L32 C5I45_11960 ENOG4105KNH Nucleic acid-binding protein C5I45_11965 ENOG4105CDE UPF0348 protein C5I45_11970 ENOG41063PX domain protein C5I45_11975 ENOG4105D78 K07001 NTE family protein C5I45_11980 ENOG4105H20 Sporulation integral membrane protein YlbJ C5I45_11985 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C5I45_11990 ENOG4106H78 methyltransferase C5I45_12020 ENOG4106UY4 Inherit from COG: Scp-like extracellular C5I45_12025 ENOG41080XQ Signal transduction protein with cbs domains C5I45_12040 ENOG41064X9 cytochrome C oxidase subunit IV C5I45_12045 ENOG4105CCU oxidase (Subunit III) C5I45_12050 ENOG4105BZ9 Cytochrome C oxidase, subunit I C5I45_12060 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C5I45_12070 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C5I45_12075 ENOG4105CNI cell division protein FtsW C5I45_12085 ENOG4105CSV Glutaminase C5I45_12095 ENOG4108IAB Phoh family C5I45_12110 ENOG4105QA2 C5I45_12115 ENOG4105CI3 gtp-binding protein typa C5I45_12140 ENOG4105D4Y metalloprotease C5I45_12150 ENOG4105ECY inositol monophosphatase C5I45_12170 ENOG4105WBI UPF0223 protein C5I45_12180 ENOG4105CXN decarboxylase C5I45_12200 ENOG4107QN2 dihydrolipoyl dehydrogenase C5I45_12205 ENOG4105C7S Dehydrogenase C5I45_12210 ENOG4105CPP Dehydrogenase, E1 component C5I45_12220 ENOG4105FQP Beta-lactamase C5I45_12225 ENOG4105C0W non-ribosomal peptide synthetase C5I45_12230 ENOG4107SQU synthase C5I45_12235 ENOG4107SQU synthase C5I45_12240 ENOG4107SQU synthase C5I45_12245 ENOG4105C0W non-ribosomal peptide synthetase C5I45_12250 ENOG4107SQU synthase C5I45_12255 ENOG4105C0W non-ribosomal peptide synthetase C5I45_12260 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C5I45_12280 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C5I45_12285 ENOG4108X4Q Hydrolase C5I45_12295 ENOG4106148 UPF0356 protein C5I45_12300 ENOG4105CN5 Metallo-Beta-Lactamase C5I45_12305 ENOG4105CPN adenine deaminase C5I45_12310 ENOG4107ZYR domain protein C5I45_12320 ENOG4105BZU Histidine kinase C5I45_12350 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C5I45_12355 ENOG4105C5H ABC transporter C5I45_12370 ENOG4105DM4 PTS System C5I45_12375 ENOG4105DE4 1-phosphofructokinase C5I45_12380 ENOG4105E98 transcriptional regulator DeoR family C5I45_12385 ENOG4107RBB ABC transporter, permease C5I45_12390 ENOG4105C19 ABC transporter C5I45_12395 ENOG4107X8C Efflux transporter RND family MFP subunit C5I45_12405 ENOG41067WU Molybdopterin converting factor (Subunit 1) C5I45_12410 ENOG4108ZAF Molybdopterin C5I45_12415 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C5I45_12420 ENOG4105CVM Molybdenum cofactor synthesis domain protein C5I45_12425 ENOG4105D06 uba thif-type nad fad binding protein C5I45_12430 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C5I45_12445 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5I45_12450 ENOG4105D8X mechanosensitive ion channel C5I45_12470 ENOG4105NQC Flavodoxin C5I45_12500 ENOG4108XRC Protein of unknown function (DUF458) C5I45_12505 ENOG4107IN1 Protein of unknown function (DUF1797) C5I45_12510 ENOG4105EPM Diguanylate phosphodiesterase C5I45_12525 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C5I45_12535 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein C5I45_12545 ENOG4105UIN C5I45_12550 ENOG4107R88 Chemotaxis protein (CheV) C5I45_12560 ENOG4105CHM Aminotransferase C5I45_12565 ENOG4105BZU Histidine kinase C5I45_12575 ENOG4105K4I Scp-like extracellular C5I45_12580 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C5I45_12585 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C5I45_12590 ENOG4105F6S Spore photoproduct lyase C5I45_12600 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C5I45_12605 ENOG4105KRI phosphocarrier protein (HPr C5I45_12615 ENOG4105CID antiterminator C5I45_12625 ENOG4105DC7 peptidase M24 C5I45_12630 ENOG4105C59 p-type ATPase C5I45_12645 ENOG4105F0V Cell wall hydrolase C5I45_12665 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C5I45_12670 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C5I45_12675 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase C5I45_12680 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C5I45_12690 ENOG4108K88 Membrane C5I45_12705 ENOG4105E14 MotA TolQ exbB proton channel C5I45_12710 ENOG4105ER2 Ompa motb domain protein C5I45_12715 ENOG41090MY MarR family Transcriptional regulator C5I45_12720 ENOG4105BZU Histidine kinase C5I45_12730 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C5I45_12735 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C5I45_12740 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) C5I45_12745 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate C5I45_12755 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C5I45_12765 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C5I45_12770 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C5I45_12775 ENOG4105BZU Histidine kinase C5I45_12780 ENOG4108TGC Acyltransferase C5I45_12790 ENOG410900G Protein of unknown function (DUF421) C5I45_12800 ENOG4105D0M Protease HtpX homolog C5I45_12810 ENOG410681C small acid-soluble spore protein C5I45_12820 ENOG4108WZW RNA polymerase sigma C5I45_12825 ENOG4107TS3 membrane protein, TerC C5I45_12830 ENOG4107T5V SNARE associated Golgi C5I45_12840 ENOG4105FDF Could be involved in DNA repair (By similarity) C5I45_12845 ENOG4105DQE DNA ligase C5I45_12870 ENOG4105V75 Transcriptional regulator C5I45_12875 ENOG4105CJW magnesium transporter C5I45_12890 ENOG4105VRS hydrolase family 18 C5I45_12895 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C5I45_12900 ENOG4108JJB ABC transporter C5I45_12905 ENOG4108W7F transporter, permease C5I45_12915 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C5I45_12920 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C5I45_12925 ENOG4108Y4K DNA-binding transcriptional activator C5I45_12930 ENOG4105D8G Major Facilitator superfamily C5I45_12940 ENOG4107TVC Glycosyl transferase, family 2 C5I45_12955 ENOG4108ZHJ Organic hydroperoxide resistance protein C5I45_12960 ENOG4105K56 Transcriptional regulator C5I45_12975 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C5I45_12980 ENOG4105CIY formyltetrahydrofolate deformylase C5I45_12985 ENOG41080TC multidrug resistance protein C5I45_12995 ENOG4108428 Inherit from COG: -acetyltransferase C5I45_13000 ENOG4108S4H thioesterase Superfamily protein C5I45_13005 ENOG4107TUM Amidinotransferase C5I45_13010 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C5I45_13015 ENOG4108JQ7 (ABC) transporter C5I45_13020 ENOG4107SN7 NLP P60 protein C5I45_13025 ENOG4105DTQ mandelate racemase muconate lactonizing C5I45_13030 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C5I45_13040 ENOG4105C3U ABC transporter C5I45_13045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5I45_13050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C5I45_13055 ENOG4108ME1 Peptidase M55 D-aminopeptidase C5I45_13065 ENOG4105C0H protease C5I45_13070 ENOG4105CKK Glycosyl transferase, family 2 C5I45_13075 ENOG4105EDW glycosyl transferase, family 39 C5I45_13085 ENOG4107R7I amino acid C5I45_13090 ENOG4107GRR phosphate transport regulator C5I45_13095 ENOG4105CJ3 phosphate transporter C5I45_13110 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C5I45_13140 ENOG41068G1 C5I45_13150 ENOG410906S phage-like element pbsx protein xkdt C5I45_13155 ENOG41066EA baseplate J family protein C5I45_13160 ENOG4105MFU Protein of unknown function (DUF2634) C5I45_13170 ENOG4105X7F C5I45_13175 ENOG4108WZM domain protein C5I45_13180 ENOG4108FKH Transglycosylase SLT domain C5I45_13180 ENOG4108FKH Transglycosylase SLT domain C5I45_13180 ENOG4108FKH Transglycosylase SLT domain C5I45_13190 ENOG4105MTC XkdN-like protein C5I45_13195 ENOG4105FR7 XkdM protein, phage-like element PBSX C5I45_13200 ENOG4105PQS phage protein C5I45_13215 ENOG41060SN C5I45_13240 ENOG4108MDF Phage Portal Protein C5I45_13245 ENOG4105IG6 Phage terminase, large subunit C5I45_13250 ENOG4108TFU terminase (Small subunit) C5I45_13290 ENOG410635T phage-like element pbsx protein C5I45_13295 ENOG4105K7W phage-related replication protein C5I45_13300 ENOG4105KWG Pfam:DUF1696 C5I45_13305 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C5I45_13320 ENOG4107TSN permease C5I45_13335 ENOG4105F3H Histidine kinase C5I45_13340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5I45_13345 ENOG4105CTX dehydratase C5I45_13350 ENOG4107QZW Altronate oxidoreductase C5I45_13355 ENOG4107KJX Transcriptional regulator C5I45_13360 ENOG4105CT4 transporter C5I45_13365 ENOG4105D2H Uronic isomerase C5I45_13380 ENOG4105Q95 Cupin 2, conserved barrel domain protein C5I45_13390 ENOG4108IXI (ABC) transporter C5I45_13395 ENOG4105C4B ABC transporter, permease C5I45_13400 ENOG4105EXQ uroporphyrinogen iii synthase hem4 C5I45_13410 ENOG41087PP glycosyltransferase MGT family C5I45_13415 ENOG4106A3M Cytochrome p-450 C5I45_13425 ENOG4108IEG Formate dehydrogenase Alpha subunit C5I45_13450 ENOG4105KT7 mgtC SapB transporter C5I45_13470 ENOG4105E98 transcriptional regulator DeoR family C5I45_13480 ENOG4105VCP PTS System C5I45_13485 ENOG4105CK1 PTS System C5I45_13490 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C5I45_13495 ENOG4105CMR udp-glucose 4-epimerase C5I45_13500 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase C5I45_13530 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase C5I45_13585 ENOG4105C28 cystathionine C5I45_13590 ENOG4105C28 cystathionine C5I45_13600 ENOG4108ZMI UPF0477 protein C5I45_13615 ENOG4105CJ1 ABC, transporter C5I45_13635 ENOG4105ENA helicase C5I45_13685 ENOG4107A88 C5I45_13690 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C5I45_13695 ENOG4105DWF phosphomethylpyrimidine kinase C5I45_13700 ENOG4105D06 uba thif-type nad fad binding protein C5I45_13720 ENOG4108VEU Thiamine monophosphate synthase C5I45_13725 ENOG4105ETU transcriptional activator (TenA C5I45_13740 ENOG4107S1Q Phosphatase C5I45_13745 ENOG4105EMS pseudouridine synthase C5I45_13750 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C5I45_13765 ENOG4105MIX Adenylate cyclase C5I45_13770 ENOG4105E4C Lytic transglycosylase catalytic C5I45_13775 ENOG4108Z18 K06886 hemoglobin C5I45_13780 ENOG4105T58 Dithiol-disulfide isomerase C5I45_13785 ENOG4105DPN Oligoendopeptidase f C5I45_13795 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C5I45_13800 ENOG4108ZCF integral membrane protein C5I45_13805 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C5I45_13820 ENOG4108JQ7 (ABC) transporter C5I45_13830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5I45_13835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C5I45_13840 ENOG4108J59 Extracellular solute-binding protein, family 5 C5I45_13845 ENOG4105C31 Tryptophanyl-tRNA synthetase C5I45_13855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5I45_13870 ENOG4108JQ7 (ABC) transporter C5I45_13875 ENOG4105C3U ABC transporter C5I45_13885 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5I45_13890 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C5I45_13905 ENOG4107RMD Basic membrane lipoprotein C5I45_13935 ENOG4105DBV ornithine carbamoyltransferase C5I45_13945 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C5I45_13950 ENOG4105C8Y Acetylornithine aminotransferase C5I45_13955 ENOG4105CAS nag kinase C5I45_13965 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C5I45_13975 ENOG4105IQ5 FAD linked oxidase domain protein C5I45_13980 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C5I45_13985 ENOG4105VG1 fes assembly suf system protein C5I45_13990 ENOG4108MXZ Esterase C5I45_13995 ENOG4108KP7 hydrolase C5I45_14000 ENOG41073B9 C5I45_14010 ENOG4107AYK membrAne C5I45_14015 ENOG4105EPR degv family C5I45_14025 ENOG4105C8Q Methyl-accepting chemotaxis C5I45_14030 ENOG4105DIH basic membrane C5I45_14035 ENOG4105QNR S1 RNA binding domain protein C5I45_14040 ENOG4108VPT UPF0234 protein C5I45_14050 ENOG4105MA6 gCN5-related N-acetyltransferase C5I45_14055 ENOG4105MYW Pentapeptide repeat protein C5I45_14065 ENOG4105SF0 DinB family C5I45_14070 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C5I45_14075 ENOG4105ETE Transcriptional regulator (LacI family C5I45_14080 ENOG4106HBX Transcriptional Regulator AraC Family C5I45_14085 ENOG4105UQX Mate efflux family protein C5I45_14095 ENOG4105CAQ asparagine synthetase C5I45_14115 ENOG4105ERH Fumarylacetoacetate hydrolase C5I45_14160 ENOG4105EYH Exonuclease C5I45_14170 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C5I45_14175 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination C5I45_14180 ENOG4108QY0 Membrane C5I45_14190 ENOG4108IG5 Transcriptional regulator C5I45_14200 ENOG4108KK1 membrane protein AbrB duplication C5I45_14205 ENOG4108INS Transcriptional regulator C5I45_14210 ENOG4107SCK Monooxygenase C5I45_14225 ENOG41060YP C5I45_14230 ENOG4106CAD Protein of unknown function (DUF3311) C5I45_14235 ENOG4105E1V na solute symporter C5I45_14240 ENOG4105K8R UPF0145 protein C5I45_14245 ENOG4105X3H Excalibur domain protein C5I45_14255 ENOG4108ZMX Domain of unknown function (DU1801) C5I45_14275 ENOG4105XVF Competence transcription factor C5I45_14295 ENOG4106YBV Methyl-accepting chemotaxis C5I45_14300 ENOG4107ZYJ bioY protein C5I45_14305 ENOG4107F3J Amp-dependent synthetase and ligase C5I45_14315 ENOG4107TB6 phosphoglycerate mutase C5I45_14320 ENOG4108HUF Transporter C5I45_14335 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C5I45_14345 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_14355 ENOG4105DF9 Lipoate-protein, ligase C5I45_14360 ENOG4108RQ5 Beta-lactamase domain-containing protein C5I45_14365 ENOG4106AXD C5I45_14375 ENOG4105DER m42 family C5I45_14390 ENOG4105ECB domain protein C5I45_14400 ENOG4105C1Q protoporphyrinogen oxidase C5I45_14405 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C5I45_14410 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C5I45_14415 ENOG4105BZ4 penicillin-binding protein C5I45_14420 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C5I45_14450 ENOG4105K59 histidine triad (HIT) protein C5I45_14455 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C5I45_14460 ENOG4105NBU tryptophan transport protein C5I45_14510 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C5I45_14520 ENOG4105EQI Metal Dependent Phosphohydrolase C5I45_14525 ENOG4106D4I domain protein C5I45_14530 ENOG4107VRP DNA repair exonuclease C5I45_14535 ENOG4105RHA ABC transporter, permease C5I45_14540 ENOG4108IUX (ABC) transporter C5I45_14550 ENOG4105CGU Enoyl-CoA hydratase C5I45_14560 ENOG4105NCW Trka-c domain protein C5I45_14565 ENOG4107S91 Sodium hydrogen exchanger C5I45_14575 ENOG4105D4P Coproporphyrinogen iii oxidase C5I45_14585 ENOG4105F1N DNA alkylation repair C5I45_14590 ENOG4105WZB UPF0342 protein C5I45_14595 ENOG4106MP8 UPF0754 membrane protein C5I45_14605 ENOG410839P C5I45_14630 ENOG4105BZ1 (ABC) transporter C5I45_14635 ENOG4105BZ1 (ABC) transporter C5I45_14645 ENOG4105IIP Membrane C5I45_14650 ENOG4105W1N transcriptional regulator C5I45_14655 ENOG4105F0I Aminotransferase C5I45_14660 ENOG4107VMI polysaccharide deacetylase C5I45_14665 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C5I45_14670 ENOG4105D64 Mechanosensitive ion channel C5I45_14680 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5I45_14685 ENOG4105WMR Protein CrcB homolog C5I45_14695 ENOG4105C37 (CBS) domain C5I45_14700 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase C5I45_14705 ENOG4105CHM Aminotransferase C5I45_14715 ENOG4105C37 (CBS) domain C5I45_14720 ENOG4105F6E Acyl-transferase C5I45_14725 ENOG4108AEY RNA polymerase sigma factor C5I45_14730 ENOG4105J37 C5I45_14740 ENOG4105C8J )-transporter C5I45_14745 ENOG4105CUB amino acid C5I45_14750 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C5I45_14755 ENOG4105BZN citrate synthase C5I45_14770 ENOG4105G6Z alkaline phosphatase C5I45_14775 ENOG4105ED1 spovr family C5I45_14810 ENOG4105WH1 Two component transcriptional regulator luxr family C5I45_14815 ENOG4105BZU Histidine kinase C5I45_14825 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C5I45_14830 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C5I45_14840 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C5I45_14845 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C5I45_14850 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C5I45_14855 ENOG4107YBY Hydrolase C5I45_14860 ENOG41080XP Cbs domain C5I45_14870 ENOG4108YBP pseudouridine synthase C5I45_14910 ENOG4105BZU Histidine kinase C5I45_14925 ENOG4105VEQ Cold shock protein C5I45_14930 ENOG4108TU7 Inherit from COG: (ABC) transporter C5I45_14935 ENOG4105CJ1 ABC, transporter C5I45_14940 ENOG4105CZV ABC transporter C5I45_14945 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C5I45_14960 ENOG4105CS1 NAD(P)H quinone oxidoreductase C5I45_14965 ENOG4105C0R drug resistance transporter emrb qaca subfamily C5I45_14970 ENOG4105CW7 secretion protein, HlyD family C5I45_14975 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C5I45_14990 ENOG4105CYN Serine protein kinase C5I45_15010 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C5I45_15020 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C5I45_15035 ENOG4105VZ8 Transcriptional regulator C5I45_15040 ENOG4107D63 C5I45_15045 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C5I45_15055 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C5I45_15060 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C5I45_15065 ENOG4105E2Y ABC, transporter C5I45_15085 ENOG4108JQ7 (ABC) transporter C5I45_15090 ENOG4105C3U ABC transporter C5I45_15095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5I45_15105 ENOG4105DEF Extracellular solute-binding protein, family 5 C5I45_15115 ENOG4105DNP FAD linked oxidase domain protein C5I45_15120 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C5I45_15125 ENOG4105EC3 peptidase S51, dipeptidase E C5I45_15235 ENOG4105TUA UPF0295 protein C5I45_15240 ENOG4105G5W regulator Fur family C5I45_15245 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5I45_15250 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C5I45_15255 ENOG4107NBY Membrane C5I45_15260 ENOG4105BZ1 (ABC) transporter C5I45_15280 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C5I45_15285 ENOG4106BXE C5I45_15290 ENOG4105CEN a g-specific adenine glycosylase C5I45_15295 ENOG41067AE Membrane-bound metal-dependent hydrolase C5I45_15300 ENOG4105EJV Membrane C5I45_15305 ENOG4105CKK Glycosyl transferase, family 2 C5I45_15310 ENOG4105D74 hydrolase C5I45_15315 ENOG4106AKJ C5I45_15335 ENOG4108TCS Glutamyl endopeptidase C5I45_15345 ENOG4105F27 Major Facilitator C5I45_15355 ENOG410902V Modulates RecA activity (By similarity) C5I45_15360 ENOG4105ECP epimerase C5I45_15375 ENOG4107Y03 Nitroreductase C5I45_15380 ENOG4105JAB phenazine biosynthesis protein, phzf family C5I45_15390 ENOG410834F Transcriptional regulator C5I45_15395 ENOG4105C0R drug resistance transporter emrb qaca subfamily C5I45_15400 ENOG4108YYS metal-dependent hydrolase (By similarity) C5I45_15415 ENOG4105H93 Acyltransferase family C5I45_15420 ENOG4105DYS nad(p)h dehydrogenase (quinone) C5I45_15425 ENOG4105U3E Transcriptional regulator C5I45_15430 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C5I45_15440 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C5I45_15450 ENOG4105BZ1 (ABC) transporter C5I45_15455 ENOG4105BZ1 (ABC) transporter C5I45_15460 ENOG4105CI1 PTS System C5I45_15465 ENOG4108Q3X Transcriptional regulator C5I45_15470 ENOG4105F8D glycoside hydrolase family 4 C5I45_15480 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C5I45_15490 ENOG4107QKR Dehydrogenase C5I45_15500 ENOG4107RUY (E1 component), alpha subunit C5I45_15520 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C5I45_15530 ENOG4105D7N magnesium and cobalt transport protein CorA C5I45_15540 ENOG4106KE4 Dehydrogenase C5I45_15560 ENOG4105D8X mechanosensitive ion channel C5I45_15570 ENOG4105UPD Calcium Proton C5I45_15575 ENOG4108ISG Major Facilitator C5I45_15580 ENOG4107U9T Pfam:Ribonuclease_BN C5I45_15590 ENOG4105KJF protein tyrosine phosphatase C5I45_15605 ENOG4105FF2 Type I DHQase C5I45_15610 ENOG4105E2X shikimate dehydrogenase C5I45_15615 ENOG4105ETE Transcriptional regulator (LacI family C5I45_15620 ENOG4107RKG DJ-1/PfpI family C5I45_15625 ENOG4105CGH 5'-nucleotidase C5I45_15640 ENOG4108RCM Nitroreductase C5I45_15645 ENOG4107414 GntR family transcriptional regulator C5I45_15650 ENOG4105CG3 alpha amylase, catalytic region C5I45_15655 ENOG4105C5Y PTS System C5I45_15695 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C5I45_15715 ENOG4108RPX mosc domain containing protein C5I45_15720 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) C5I45_15745 ENOG4108MRH transcriptional regulatory protein C5I45_15765 ENOG4107QPK )-transporter C5I45_15770 ENOG4108J20 pectate lyase C5I45_15785 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C5I45_15795 ENOG4105FDU atp-dependent rna helicase C5I45_15800 ENOG4105C5H ABC transporter C5I45_15805 ENOG4105DXB Major Facilitator superfamily C5I45_15810 ENOG4107SWG transcriptional regulator MERR family C5I45_15815 ENOG4105C5H ABC transporter C5I45_15820 ENOG4107TVC Glycosyl transferase, family 2 C5I45_15825 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C5I45_15830 ENOG4105FKZ Methyl-accepting chemotaxis C5I45_15835 ENOG4105C26 Dehydrogenase C5I45_15840 ENOG4105CUB amino acid C5I45_15845 ENOG4105EU0 Major facilitator Superfamily C5I45_15850 ENOG41090R9 glycosyltransferase C5I45_15855 ENOG4107R51 Glycosyl transferase, family 2 C5I45_15860 ENOG41090R9 glycosyltransferase C5I45_15870 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C5I45_15875 ENOG4105E0M Sulfatase C5I45_15885 ENOG4105CJ1 ABC, transporter C5I45_15900 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C5I45_15905 ENOG4108R1P C5I45_15910 ENOG41061H0 Monooxygenase C5I45_15915 ENOG41082F9 transcriptional regulator C5I45_15920 ENOG4106I4J membrane C5I45_15940 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C5I45_15945 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C5I45_15950 ENOG4105H67 Protein of unknown function (DUF421) C5I45_15960 ENOG4105M18 -acetyltransferase C5I45_15965 ENOG4105WEF catalase C5I45_15980 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C5I45_15990 ENOG4105CDY transcriptional regulatory protein C5I45_16020 ENOG4105CJ1 ABC, transporter C5I45_16025 ENOG4105CHR reductase C5I45_16035 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5I45_16055 ENOG4105WH1 Two component transcriptional regulator luxr family C5I45_16060 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C5I45_16065 ENOG4105CBD Diacylglycerol kinase C5I45_16075 ENOG4108IG5 Transcriptional regulator C5I45_16080 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5I45_16085 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C5I45_16090 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5I45_16095 ENOG4105CK7 Sodium proline symporter C5I45_16100 ENOG4105KT7 mgtC SapB transporter C5I45_16105 ENOG4105CRN Aminoglycoside phosphotransferase C5I45_16115 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C5I45_16120 ENOG4105C4R Atp-dependent dna helicase C5I45_16135 ENOG4105CBC glutamate synthase C5I45_16140 ENOG4105KGF protein, YerC YecD C5I45_16145 ENOG4108R5T secreted protein C5I45_16160 ENOG4105C12 Phosphoribosylglycinamide synthetase C5I45_16165 ENOG4105DC1 bifunctional purine biosynthesis protein purh C5I45_16170 ENOG4108V3E phosphoribosylglycinamide formyltransferase C5I45_16175 ENOG4105CXB phosphoribosylaminoimidazole synthetase C5I45_16185 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C5I45_16190 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C5I45_16195 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C5I45_16200 ENOG4105C8V SAICAR synthetase C5I45_16205 ENOG4105C83 adenylosuccinate lyase C5I45_16210 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C5I45_16215 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C5I45_16240 ENOG4105C7N Xanthine uracil vitamin C permease C5I45_16255 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C5I45_16270 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C5I45_16275 ENOG4105C85 amino acid C5I45_16280 ENOG4107STQ Multicopper oxidase C5I45_16305 ENOG4105JVQ RNA Polymerase C5I45_16310 ENOG4108P49 AntiSigma factor C5I45_16315 ENOG4105EXC Acyl-transferase C5I45_16325 ENOG4108WV1 Pfam:DUF477 C5I45_16330 ENOG4105DQX Zinc finger domain C5I45_16335 ENOG41087YS Phage shock protein A C5I45_16350 ENOG4105CT4 transporter C5I45_16355 ENOG4105CPQ Dehydrogenase C5I45_16360 ENOG4105PGZ NB-ARC domain C5I45_16380 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C5I45_16385 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C5I45_16390 ENOG4108TYN CAAX amino terminal protease family protein C5I45_16400 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C5I45_16405 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C5I45_16410 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C5I45_16415 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C5I45_16420 ENOG4105C5H ABC transporter C5I45_16425 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C5I45_16430 ENOG410801F ribosomal-protein-alanine acetyltransferase C5I45_16435 ENOG41072GX Peptidase M22 Glycoprotease C5I45_16440 ENOG4105K8N protein family UPF0079, ATPase C5I45_16445 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C5I45_16485 ENOG4107QNK )-transporter C5I45_16505 ENOG4107QTZ amino acid C5I45_16525 ENOG4105DJ2 Major Facilitator Superfamily C5I45_16530 ENOG4105JXH GntR family transcriptional regulator C5I45_16535 ENOG4108TZY GntR Family Transcriptional Regulator C5I45_16540 ENOG4108SUT Major Facilitator Superfamily C5I45_16545 ENOG41090UD (LipO)protein C5I45_16550 ENOG4105FQP Beta-lactamase C5I45_16570 ENOG4105DRR Transcriptional regulator, GntR family C5I45_16575 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5I45_16580 ENOG4105F2W methyltransferase C5I45_16595 ENOG41090E6 transcriptional regulator MERR family C5I45_16615 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5I45_16620 ENOG4105C2C drug resistance transporter, Bcr CflA C5I45_16630 ENOG4108JYZ YitT family C5I45_16645 ENOG41062ES Transcriptional regulator C5I45_16650 ENOG4105C57 major facilitator superfamily C5I45_16660 ENOG4105EYF MMPL domain protein C5I45_16665 ENOG4108VB1 regulatoR C5I45_16670 ENOG4105ENE Histidine kinase C5I45_16680 ENOG4105PGS Spore coat protein C5I45_16685 ENOG4105E2A Dehydrogenase C5I45_16705 ENOG4108JGH Tetr family transcriptional regulator C5I45_16710 ENOG4105EQ0 Major Facilitator superfamily C5I45_16725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5I45_16735 ENOG4105VUF Transcriptional regulator C5I45_16740 ENOG4105DQ4 alcohol dehydrogenase C5I45_16765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5I45_16785 ENOG4105H3G oxidoreductase C5I45_16790 ENOG4105PGM cation diffusion facilitator family transporter C5I45_16800 ENOG4105DNP FAD linked oxidase domain protein C5I45_16820 ENOG4105DXI Major Facilitator superfamily C5I45_16825 ENOG4107U9B transcriptional regulator C5I45_16830 ENOG4105CE7 Amidase, hydantoinase carbamoylase family C5I45_16835 ENOG4108MCI Transcriptional regulator, ARAC family C5I45_16840 ENOG4105CH2 amidohydrolase C5I45_16845 ENOG4105C44 Serine transporter C5I45_16850 ENOG4105KME endoribonuclease L-psp C5I45_16855 ENOG4108WYP Transcriptional regulator C5I45_16860 ENOG4107RCH Diaminopropionate ammonia-lyase C5I45_16870 ENOG4105IRW patatin-like phospholipase family protein C5I45_16890 ENOG41087NI Sulfite exporter TauE/SafE C5I45_16895 ENOG4105VFE sira family C5I45_16900 ENOG4107TPS domain protein C5I45_16905 ENOG4105VFE sira family C5I45_16915 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C5I45_16920 ENOG4105XTG Pfam:DUF156 C5I45_16930 ENOG4105VEQ Cold shock protein C5I45_16935 ENOG4108RYK Nad-dependent epimerase dehydratase C5I45_16940 ENOG4108Z40 Transcriptional regulator C5I45_16945 ENOG4105D1H recombination factor protein RarA C5I45_16955 ENOG4108ZMQ domain protein C5I45_16965 ENOG4105K56 Transcriptional regulator C5I45_16980 ENOG4105CSH Transporter C5I45_16985 ENOG4105C94 Transporter C5I45_17005 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C5I45_17045 ENOG410906U SprT-like C5I45_17060 ENOG41064BQ Phosphatase C5I45_17070 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C5I45_17075 ENOG4105WN5 stage II sporulation protein C5I45_17080 ENOG4107SGM protein serine threonine phosphatase C5I45_17085 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C5I45_17090 ENOG4105FUA antagonist C5I45_17095 ENOG4107MMM Anti-sigma-factor antagonist C5I45_17100 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C5I45_17110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C5I45_17115 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C5I45_17120 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C5I45_17130 ENOG4105CKV Membrane C5I45_17135 ENOG410905X membrane-flanked domain protein C5I45_17140 ENOG4105C1J atp-dependent rna helicase C5I45_17145 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C5I45_17150 ENOG4105CPF Cell wall formation (By similarity) C5I45_17155 ENOG4105SZ6 Thioredoxin C5I45_17175 ENOG4105FDT acyl-CoA dehydrogenase C5I45_17190 ENOG4105CJ1 ABC, transporter C5I45_17195 ENOG4106F5Q Membrane C5I45_17200 ENOG4107QJT sodium dicarboxylate symporter C5I45_17205 ENOG4108MRH transcriptional regulatory protein C5I45_17210 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C5I45_17215 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C5I45_17230 ENOG41082W1 Cupin 2, conserved barrel domain protein C5I45_17235 ENOG4105QVS general stress protein C5I45_17240 ENOG4105EU9 C5I45_17245 ENOG4105KPY Small multidrug resistance protein C5I45_17250 ENOG4105RXJ C5I45_17255 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) C5I45_17270 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C5I45_17355 ENOG4105C0X amino acid C5I45_17365 ENOG4107R8N Glycosyl transferase, family 2 C5I45_17370 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C5I45_17385 ENOG4105C9U ATP-dependent DNA helicase RecQ C5I45_17395 ENOG4105VCH membrane C5I45_17405 ENOG410606W general stress protein C5I45_17420 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C5I45_17430 ENOG4105ETD TRANSCRIPTIONal C5I45_17435 ENOG4107QM2 Aldo Keto reductase C5I45_17440 ENOG4107RVG penicillin-binding protein C5I45_17445 ENOG41061CK Antibiotic biosynthesis monooxygenase C5I45_17455 ENOG4105XJB lipolytic protein G-D-S-L family C5I45_17460 ENOG4107258 Transcriptional regulator C5I45_17470 ENOG4105P4J Allophanate hydrolase, subunit 1 C5I45_17475 ENOG4105CFM UPF0317 protein C5I45_17480 ENOG4105C5A transporter C5I45_17485 ENOG4105E7W lamb ycsf family protein C5I45_17505 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase C5I45_17525 ENOG4108ZYE Transcriptional regulator C5I45_17530 ENOG4108T5E Copper resistance protein C5I45_17535 ENOG4105KTB nuclear export factor GLE1 C5I45_17540 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C5I45_17550 ENOG4105C26 Dehydrogenase C5I45_17555 ENOG4108JPW Aminotransferase C5I45_17565 ENOG4105YVS arsR family transcriptional regulator C5I45_17570 ENOG41067V3 Antibiotic biosynthesis monooxygenase C5I45_17575 ENOG4108DBC nitroreductase C5I45_17580 ENOG4105R8C Transcriptional regulator C5I45_17595 ENOG4108IPW abc transporter atp-binding protein C5I45_17600 ENOG4105CM4 permease protein C5I45_17605 ENOG4105DHS permease protein C5I45_17615 ENOG4105CFH Aspartokinase C5I45_17635 ENOG4105BZU Histidine kinase C5I45_17640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5I45_17645 ENOG4107WD8 ABC transporter, permease C5I45_17655 ENOG4108PGP mmge prpd family protein C5I45_17660 ENOG4105CH2 amidohydrolase C5I45_17670 ENOG4108HW4 amino acid AbC transporter C5I45_17675 ENOG4105EAB amino acid AbC transporter C5I45_17680 ENOG4108XSB acetyltransferase, (GNAT) family C5I45_17685 ENOG4105CPU Monooxygenase C5I45_17700 ENOG4105E1K spore germination protein C5I45_17715 ENOG4105DUX Transporter C5I45_17720 ENOG41069ZX C5I45_17725 ENOG41069ZX C5I45_17730 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C5I45_17735 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C5I45_17740 ENOG4106P55 Transcriptional regulator C5I45_17750 ENOG4105DRP amino acid AbC transporter C5I45_17755 ENOG4105CDA abc transporter atp-binding protein C5I45_17770 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C5I45_17790 ENOG4105CEY Amp-dependent synthetase and ligase C5I45_17795 ENOG4105KVH Transcriptional regulator C5I45_17800 ENOG4108VA3 3-hexulose-6-phosphate synthase C5I45_17805 ENOG41080HJ 6-phospho 3-hexuloisomerase C5I45_17830 ENOG4105HHM rdd domain containing protein C5I45_17835 ENOG4105E2A Dehydrogenase C5I45_17840 ENOG4105CKI cobalamin synthesis protein C5I45_17845 ENOG4108IFG nitrite reductase, (NAD(P)H) C5I45_17850 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C5I45_17855 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C5I45_17860 ENOG4105CAY ferredoxin--nadp reductase C5I45_17865 ENOG4107YHD transcriptional regulator C5I45_17870 ENOG4105CK7 Sodium proline symporter C5I45_17875 ENOG4105C26 Dehydrogenase C5I45_17885 ENOG410756H nucleotidyltransferase C5I45_17890 ENOG4105I82 acetyl xylan esterase C5I45_17895 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C5I45_17900 ENOG4105DJB Major Facilitator Superfamily C5I45_17905 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C5I45_17910 ENOG4105I1F Resistance protein C5I45_17920 ENOG4107RA1 nh(3)-dependent nad( ) synthetase C5I45_17925 ENOG4105EIG urea carboxylase-associated protein 1 C5I45_17955 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C5I45_17990 ENOG4107SQ8 Glycine betaine C5I45_17995 ENOG4108IJ7 Glycine betaine C5I45_18000 ENOG41079KZ Major Facilitator Superfamily C5I45_18010 ENOG4108TTB tellurium resistance protein C5I45_18015 ENOG4107TS3 membrane protein, TerC C5I45_18020 ENOG4106FN3 tellurium resistance protein C5I45_18025 ENOG4106FN3 tellurium resistance protein C5I45_18030 ENOG4108N0M stress protein C5I45_18035 ENOG4105DEN Luciferase family C5I45_18045 ENOG4105DIK (ABC) transporter C5I45_18050 ENOG4105DSE periplasmic solute binding protein C5I45_18060 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C5I45_18090 ENOG4107SET aldo keto reductase C5I45_18095 ENOG41060AI SEC-C motif C5I45_18100 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C5I45_18105 ENOG4107RB3 L-asparaginase C5I45_18110 ENOG4105J7D transcriptional regulator C5I45_18115 ENOG4105C0R drug resistance transporter emrb qaca subfamily C5I45_18120 ENOG4107EPV Aminotransferase class V C5I45_18125 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) C5I45_18130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C5I45_18135 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C5I45_18140 ENOG4105DGI Alkaline phosphatase C5I45_18165 ENOG4105XXY Thioredoxin C5I45_18170 ENOG4108VGI doxx family C5I45_18175 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C5I45_18180 ENOG4108TVJ Nitroreductase C5I45_18185 ENOG41076HS cation diffusion facilitator family transporter C5I45_18210 ENOG4105CSV Glutaminase C5I45_18220 ENOG4108J5H Homocysteine s-methyltransferase C5I45_18225 ENOG4108IQI permease C5I45_18230 ENOG4105CM2 brancheD-chain amino acid aminotransferase C5I45_18240 ENOG4105C72 UPF0176 protein C5I45_18255 ENOG4107ZTW SNARE associated Golgi C5I45_18260 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C5I45_18265 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C5I45_18270 ENOG4107SCQ Iron-containing alcohol dehydrogenase C5I45_18310 ENOG4105CXY transporter C5I45_18315 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C5I45_18330 ENOG4107QTZ amino acid C5I45_18345 ENOG4106DDH Sporulation-specific SASP protein C5I45_18370 ENOG4105CJ1 ABC, transporter C5I45_18375 ENOG4105WH1 Two component transcriptional regulator luxr family C5I45_18380 ENOG4105BZU Histidine kinase C5I45_18395 ENOG41061AU MarR family Transcriptional regulator C5I45_18405 ENOG41067MG lrgb family C5I45_18415 ENOG4106K80 C5I45_18440 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C5I45_18445 ENOG4107U5W ybbr family C5I45_18450 ENOG4105C8B TIGR00159 family C5I45_18460 ENOG4105EMN RNA polymerase sigma factor C5I45_18490 ENOG4105EWC Purine nucleoside phosphorylase C5I45_18500 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C5I45_18515 ENOG4105D17 glycoside hydrolase, family 3 domain protein C5I45_18520 ENOG4105EHZ conserved protein UCP016719 C5I45_18525 ENOG410874W AraC family transcriptional regulator C5I45_18545 ENOG4108SA1 esterase C5I45_18555 ENOG4105CHH sulfate transporter C5I45_18570 ENOG4108JPW Aminotransferase C5I45_18635 ENOG4108NMV polysaccharide deacetylase C5I45_18650 ENOG4105D1F ATP-binding protein C5I45_18670 ENOG4108I0C methyltransferase C5I45_18675 ENOG4108UJD 30S ribosomal protein S9 C5I45_18680 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C5I45_18685 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C5I45_18690 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C5I45_18695 ENOG4108JJB ABC transporter C5I45_18700 ENOG4108JJB ABC transporter C5I45_18705 ENOG4108ZT0 50S ribosomal protein l17 C5I45_18710 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5I45_18715 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C5I45_18720 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C5I45_18730 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C5I45_18740 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C5I45_18745 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C5I45_18750 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C5I45_18755 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C5I45_18760 ENOG4105VPB 50S ribosomal protein L30 C5I45_18765 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C5I45_18770 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C5I45_18775 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C5I45_18780 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C5I45_18790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C5I45_18800 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C5I45_18805 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C5I45_18810 ENOG41082SA 50s ribosomal protein l29 C5I45_18815 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C5I45_18820 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C5I45_18825 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C5I45_18830 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C5I45_18835 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C5I45_18840 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C5I45_18845 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C5I45_18850 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C5I45_18855 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C5I45_18860 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C5I45_18865 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C5I45_18870 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C5I45_18875 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C5I45_18880 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C5I45_18885 ENOG4105XPM ribosomal protein C5I45_18890 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5I45_18895 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5I45_18900 ENOG4107Y49 methyltransferase C5I45_18905 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C5I45_18910 ENOG4108VZM 50s ribosomal protein L10 C5I45_18920 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C5I45_18925 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C5I45_18945 ENOG4105M0M Tetracycline resistance protein C5I45_18950 ENOG4105C2N RNA methyltransferase TrmH family group 3 C5I45_18955 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) C5I45_18965 ENOG4105D7W serine acetyltransferase C5I45_18975 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C5I45_18980 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C5I45_18985 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C5I45_18990 ENOG4105CTP PilT protein domain protein C5I45_18995 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C5I45_19000 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C5I45_19010 ENOG4105BZ1 (ABC) transporter C5I45_19030 ENOG41066A3 ATP guanido phosphotransferase C5I45_19035 ENOG4108Z0C Uvrb UvrC protein C5I45_19120 ENOG4105CRK lysyL-tRNA synthetase C5I45_19125 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C5I45_19135 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C5I45_19140 ENOG4105KRF dihydroneopterin aldolase C5I45_19145 ENOG4105EEI dihydropteroate synthase C5I45_19150 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C5I45_19155 ENOG4105DDQ anthranilate synthase C5I45_19160 ENOG4105CRQ synthase (Component I) C5I45_19165 ENOG4105C6T cysteine synthase C5I45_19170 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase C5I45_19175 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C5I45_19180 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C5I45_19185 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C5I45_19190 ENOG4108UGV hypoxanthine phosphoribosyltransferase C5I45_19195 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C5I45_19225 ENOG41060GV RNA binding s1 domain protein C5I45_19240 ENOG4105VYY sporulation protein yabp C5I45_19245 ENOG41082I2 s4 domain protein C5I45_19250 ENOG4108IY2 MazG family C5I45_19260 ENOG4108M14 stage v sporulation protein t C5I45_19265 ENOG4108JA2 transcriptioN-repair coupling factor C5I45_19280 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C5I45_19285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C5I45_19290 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C5I45_19295 ENOG4105K4W Could be involved in septation (By similarity) C5I45_19300 ENOG4105KME endoribonuclease L-psp C5I45_19305 ENOG4105DFT pur operon repressor C5I45_19310 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C5I45_19315 ENOG4105XEW small acid-soluble spore protein C5I45_19320 ENOG4105W42 Veg protein C5I45_19325 ENOG4105XFA sporulation peptidase YabG C5I45_19330 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C5I45_19340 ENOG41069ER domain protein C5I45_19345 ENOG4105F8V Hydrolase, tatD family C5I45_19350 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C5I45_19355 ENOG4105KRN Transcriptional regulator, abrb family C5I45_19360 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C5I45_19365 ENOG4105VC4 domain protein C5I45_19370 ENOG41060K3 Methyltransferase C5I45_19380 ENOG4105MA4 psp1 domain protein C5I45_19385 ENOG4105FA2 dna polymerase iii C5I45_19390 ENOG4105XVJ Protein of unknown function (DUF327) C5I45_19395 ENOG4105X0R protein from nitrogen regulatory protein P-II C5I45_19400 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C5I45_19405 ENOG4105CXN decarboxylase C5I45_19410 ENOG4105CDW Resistance protein C5I45_19450 ENOG41067KS pro-sigma K processing C5I45_19460 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C5I45_19465 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C5I45_19470 ENOG4105C6E dna polymerase iii C5I45_19480 ENOG4108Z6B deaminase C5I45_19485 ENOG4105GTG Isochorismatase C5I45_19490 ENOG4105VRS hydrolase family 18 C5I45_19500 ENOG4105ZMH deoxynucleoside kinase C5I45_19510 ENOG4105BZW Glycerate kinase C5I45_19515 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C5I45_19520 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C5I45_19525 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C5I45_19535 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C5I45_19570 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5I45_19575 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5I45_19585 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C5I45_19590 ENOG410848D S4 domain protein YaaA C5I45_19595 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)