locus-tag	class	description
C5I45_00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C5I45_00020	COG0706	membrane insertase activity
C5I45_00025	COG1847	R3H domain protein
C5I45_00050	COG1192	Involved in chromosome partitioning
C5I45_00055	COG1475	DNA binding
C5I45_00070	COG3949	Membrane
C5I45_00075	COG4481	Protein conserved in bacteria
C5I45_00080	COG0243	molybdopterin cofactor binding
C5I45_00085	COG0012	GTP binding
C5I45_00095	COG0629	single-stranded DNA binding
C5I45_00105	COG2169	Transcriptional regulator
C5I45_00110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5I45_00115	COG0708	Exodeoxyribonuclease III
C5I45_00120	COG1609	Transcriptional regulator
C5I45_00125	COG0346	lactoylglutathione lyase activity
C5I45_00130	COG0477	Major facilitator Superfamily
C5I45_00130	COG2814	Major facilitator Superfamily
C5I45_00135	COG1266	CAAX protease self-immunity
C5I45_00140	COG1331	Highly conserved protein containing a thioredoxin domain
C5I45_00145	COG1331	Highly conserved protein containing a thioredoxin domain
C5I45_00150	COG1811	Na channel or pump
C5I45_00155	COG4978	Transcriptional regulator
C5I45_00155	COG0789	Transcriptional regulator
C5I45_00165	COG0697	spore germination
C5I45_00170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5I45_00200	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_00205	COG0583	DNA-binding transcription factor activity
C5I45_00210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5I45_00225	COG1846	Transcriptional regulator
C5I45_00230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5I45_00235	COG1846	Transcriptional regulator
C5I45_00240	COG0778	Nitroreductase
C5I45_00250	COG2211	Major facilitator Superfamily
C5I45_00255	COG2318	DinB family
C5I45_00260	COG1802	Transcriptional regulator
C5I45_00265	COG1621	beta-fructofuranosidase activity
C5I45_00270	COG1621	beta-fructofuranosidase activity
C5I45_00275	COG0697	spore germination
C5I45_00295	COG1733	regulation of RNA biosynthetic process
C5I45_00300	COG5577	PFAM Coat F domain
C5I45_00310	COG4241	membrane
C5I45_00315	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C5I45_00335	COG0438	transferase activity, transferring glycosyl groups
C5I45_00340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C5I45_00350	COG0297	glycogen (starch) synthase activity
C5I45_00355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5I45_00360	COG3093	addiction module antidote protein HigA
C5I45_00375	COG0305	Participates in initiation and elongation during chromosome replication
C5I45_00380	COG0346	lactoylglutathione lyase activity
C5I45_00415	COG0745	RESPONSE REGULATOR receiver
C5I45_00420	COG5002	protein histidine kinase activity
C5I45_00425	COG4863	YycH protein
C5I45_00430	COG4853	Protein conserved in bacteria
C5I45_00435	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5I45_00440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5I45_00450	COG5002	protein histidine kinase activity
C5I45_00455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5I45_00470	COG0488	(ABC) transporter
C5I45_00480	COG3829	transcription factor binding
C5I45_00485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5I45_00490	COG0833	amino acid
C5I45_00495	COG0010	Belongs to the arginase family
C5I45_00500	COG0457	Tetratricopeptide repeat
C5I45_00505	COG0456	acetyltransferase
C5I45_00510	COG0667	Aldo Keto reductase
C5I45_00515	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C5I45_00570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C5I45_00575	COG2068	MobA-Related Protein
C5I45_00590	COG2080	2 iron, 2 sulfur cluster binding
C5I45_00600	COG1113	amino acid transport
C5I45_00605	COG3634	alkyl hydroperoxide reductase activity
C5I45_00610	COG0450	alkyl hydroperoxide reductase
C5I45_00620	COG1714	RDD family
C5I45_00625	COG2814	Major facilitator Superfamily
C5I45_00630	COG0640	Transcriptional regulator
C5I45_00640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5I45_00645	COG1012	belongs to the aldehyde dehydrogenase family
C5I45_00650	COG1309	transcriptional regulator
C5I45_00660	COG3239	Fatty acid desaturase
C5I45_00665	COG4585	Histidine kinase
C5I45_00670	COG2197	response regulator
C5I45_00675	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_00690	COG2814	Major facilitator Superfamily
C5I45_00695	COG0667	Aldo Keto reductase
C5I45_00700	COG1349	DNA-binding transcription factor activity
C5I45_00730	COG2814	Major facilitator Superfamily
C5I45_00740	COG1082	Xylose isomerase domain protein TIM barrel
C5I45_00755	COG0745	RESPONSE REGULATOR receiver
C5I45_00760	COG2205	protein histidine kinase activity
C5I45_00765	COG1136	(ABC) transporter
C5I45_00770	COG0577	efflux transmembrane transporter activity
C5I45_00775	COG5294	Protein conserved in bacteria
C5I45_00780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5I45_00810	COG0561	phosphatase activity
C5I45_00815	COG2390	Transcriptional regulator
C5I45_00825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5I45_00830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C5I45_00835	COG0833	amino acid
C5I45_00840	COG0010	Belongs to the arginase family
C5I45_00865	COG3507	Belongs to the glycosyl hydrolase 43 family
C5I45_00870	COG0494	nUDIX hydrolase
C5I45_00880	COG0589	response to stress
C5I45_00885	COG0697	spore germination
C5I45_00980	COG0513	Belongs to the DEAD box helicase family
C5I45_00985	COG2270	Major facilitator Superfamily
C5I45_00995	COG2273	Hydrolase Family 16
C5I45_01000	COG2851	Citrate transporter
C5I45_01005	COG0693	protein deglycase activity
C5I45_01005	COG0753	catalase activity
C5I45_01020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5I45_01025	COG0500	methyltransferase
C5I45_01030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5I45_01035	COG4894	glucomannan catabolic process
C5I45_01045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5I45_01055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5I45_01060	COG2508	Transcriptional regulator
C5I45_01065	COG3842	ATPase activity
C5I45_01070	COG0726	polysaccharide deacetylase
C5I45_01075	COG3493	citrate carrier protein
C5I45_01080	COG1271	oxidase subunit
C5I45_01085	COG1294	oxidase, subunit
C5I45_01090	COG4988	ABC transporter
C5I45_01095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5I45_01100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5I45_01105	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5I45_01110	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C5I45_01115	COG0753	catalase activity
C5I45_01125	COG1482	cell wall glycoprotein biosynthetic process
C5I45_01130	COG1940	carbohydrate kinase activity
C5I45_01135	COG2723	6-phospho-beta-galactosidase activity
C5I45_01140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5I45_01145	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5I45_01150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5I45_01155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5I45_01160	COG0640	Transcriptional regulator
C5I45_01170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_01175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_01190	COG3711	transcriptional antiterminator
C5I45_01190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5I45_01195	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5I45_01200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5I45_01205	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5I45_01210	COG1486	melibiose metabolic process
C5I45_01215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5I45_01220	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C5I45_01230	COG1696	Membrane protein involved in D-alanine export
C5I45_01255	COG1575	Belongs to the MenA family. Type 1 subfamily
C5I45_01260	COG2357	RelA SpoT domain protein
C5I45_01265	COG1442	glycosyl transferase family 8
C5I45_01270	COG1404	Belongs to the peptidase S8 family
C5I45_01275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5I45_01280	COG0346	lactoylglutathione lyase activity
C5I45_01285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5I45_01290	COG0789	Transcriptional regulator
C5I45_01295	COG4895	conserved protein (DUF2196)
C5I45_01300	COG1346	cytolysis
C5I45_01310	COG0583	DNA-binding transcription factor activity
C5I45_01330	COG2822	iron ion transport
C5I45_01335	COG2837	iron assimilation
C5I45_01340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C5I45_01360	COG1309	transcriptional regulator
C5I45_01365	COG2246	polysaccharide biosynthetic process
C5I45_01370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5I45_01370	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5I45_01375	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C5I45_01380	COG2261	transglycosylase associated protein
C5I45_01385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5I45_01390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5I45_01410	COG0454	-acetyltransferase
C5I45_01415	COG0772	Belongs to the SEDS family
C5I45_01420	COG0778	Nitroreductase
C5I45_01425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5I45_01430	COG1404	Belongs to the peptidase S8 family
C5I45_01440	COG3711	transcriptional antiterminator
C5I45_01445	COG1263	PTS System
C5I45_01445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5I45_01450	COG1621	beta-fructofuranosidase activity
C5I45_01460	COG0351	phosphomethylpyrimidine kinase
C5I45_01465	COG1695	Transcriptional regulator
C5I45_01480	COG1216	Glycosyl transferase, family 2
C5I45_01495	COG2233	PERMEase
C5I45_01500	COG2363	Small membrane protein
C5I45_01510	COG0463	Glycosyl transferase, family 2
C5I45_01515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5I45_01520	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5I45_01525	COG0456	acetyltransferase
C5I45_01530	COG2089	acid synthase
C5I45_01535	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C5I45_01540	COG3980	spore coat polysaccharide biosynthesis protein
C5I45_01545	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C5I45_01550	COG1088	dTDP-glucose 4,6-dehydratase activity
C5I45_01555	COG1091	dTDP-4-dehydrorhamnose reductase activity
C5I45_01560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C5I45_01570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5I45_01575	COG1012	belongs to the aldehyde dehydrogenase family
C5I45_01580	COG4187	Peptidase family M20/M25/M40
C5I45_01585	COG0833	amino acid
C5I45_01590	COG2814	Major facilitator Superfamily
C5I45_01595	COG2814	Major facilitator Superfamily
C5I45_01625	COG0436	Aminotransferase
C5I45_01630	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_01640	COG0280	phosphate acetyltransferase
C5I45_01645	COG2855	membrane
C5I45_01650	COG0583	DNA-binding transcription factor activity
C5I45_01670	COG1695	Transcriptional regulator
C5I45_01685	COG1078	dGTPase activity
C5I45_01690	COG3465	dGTPase activity
C5I45_01695	COG0531	amino acid
C5I45_01705	COG1846	Transcriptional regulator
C5I45_01710	COG1942	4-Oxalocrotonate Tautomerase
C5I45_01715	COG1994	Peptidase M50
C5I45_01730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5I45_01735	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C5I45_01740	COG0010	Belongs to the arginase family
C5I45_01785	COG0457	Tetratricopeptide repeat
C5I45_01790	COG4506	Protein conserved in bacteria
C5I45_01800	COG2223	nitrite transmembrane transporter activity
C5I45_01805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5I45_01815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5I45_01820	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C5I45_01825	COG1140	nitrate reductase beta subunit
C5I45_01830	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C5I45_01835	COG2181	nitrate reductase activity
C5I45_01845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5I45_01850	COG1132	(ABC) transporter
C5I45_01865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5I45_01870	COG0247	lactate metabolic process
C5I45_01870	COG2181	nitrate reductase activity
C5I45_01885	COG4821	SIS domain
C5I45_01890	COG2204	response regulator
C5I45_01895	COG0191	fructose-bisphosphate aldolase activity
C5I45_01905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5I45_01910	COG1494	fructose-1,6-bisphosphatase
C5I45_01915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5I45_01920	COG0254	rRNA binding
C5I45_01930	COG0281	malic enzyme
C5I45_01935	COG0679	Auxin Efflux Carrier
C5I45_01940	COG0789	Transcriptional regulator
C5I45_01945	COG0346	lactoylglutathione lyase activity
C5I45_01950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5I45_01955	COG2890	protein-(glutamine-N5) methyltransferase activity
C5I45_01975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5I45_01980	COG0009	L-threonylcarbamoyladenylate synthase
C5I45_01990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5I45_01995	COG0698	ribose 5-phosphate isomerase
C5I45_02025	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5I45_02065	COG4836	Membrane
C5I45_02075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5I45_02080	COG2385	sporulation resulting in formation of a cellular spore
C5I45_02085	COG2304	oxidoreductase activity
C5I45_02090	COG2304	oxidoreductase activity
C5I45_02095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5I45_02105	COG0457	Tetratricopeptide repeat
C5I45_02110	COG1994	Peptidase M50
C5I45_02115	COG3237	CsbD-like
C5I45_02120	COG0831	urea catabolic process
C5I45_02135	COG1959	2 iron, 2 sulfur cluster binding
C5I45_02145	COG0726	polysaccharide deacetylase
C5I45_02160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5I45_02175	COG1247	-acetyltransferase
C5I45_02180	COG0739	heme binding
C5I45_02190	COG0671	phosphoesterase, PA-phosphatase related
C5I45_02195	COG0772	Belongs to the SEDS family
C5I45_02200	COG0347	Belongs to the P(II) protein family
C5I45_02205	COG0004	ammonium transporteR
C5I45_02210	COG1335	isochorismatase
C5I45_02215	COG0477	Major facilitator Superfamily
C5I45_02220	COG1953	Uracil, thiamine, allantoin
C5I45_02225	COG2814	Major facilitator Superfamily
C5I45_02230	COG1846	Transcriptional regulator
C5I45_02235	COG1609	Transcriptional regulator
C5I45_02240	COG1077	Cell shape determining protein MreB Mrl
C5I45_02245	COG4786	Flagellar basal body rod
C5I45_02250	COG4786	Flagellar basal body rod
C5I45_02255	COG0457	Tetratricopeptide repeat
C5I45_02280	COG0629	single-stranded DNA binding
C5I45_02285	COG1349	DNA-binding transcription factor activity
C5I45_02290	COG0561	phosphatase activity
C5I45_02295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5I45_02300	COG4715	Zinc finger, swim domain protein
C5I45_02315	COG3944	biosynthesis protein
C5I45_02320	COG0489	protein tyrosine kinase activity
C5I45_02325	COG4464	protein tyrosine phosphatase activity
C5I45_02330	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5I45_02335	COG3878	Protein conserved in bacteria
C5I45_02350	COG5444	nuclease activity
C5I45_02360	COG0583	DNA-binding transcription factor activity
C5I45_02365	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5I45_02375	COG2059	Chromate
C5I45_02380	COG2059	Chromate
C5I45_02385	COG1522	sequence-specific DNA binding
C5I45_02390	COG0405	Gamma-glutamyltransferase
C5I45_02400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5I45_02410	COG5337	Spore coat protein CotH
C5I45_02425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5I45_02430	COG0583	DNA-binding transcription factor activity
C5I45_02435	COG0028	Belongs to the TPP enzyme family
C5I45_02440	COG3527	Alpha-acetolactate decarboxylase
C5I45_02445	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5I45_02450	COG3103	Sh3 type 3 domain protein
C5I45_02455	COG1879	ABC-type sugar transport system periplasmic component
C5I45_02460	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5I45_02465	COG1129	ABC transporter
C5I45_02475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5I45_02480	COG1609	Transcriptional regulator
C5I45_02490	COG0814	amino acid
C5I45_02495	COG0697	spore germination
C5I45_02505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5I45_02515	COG2843	Capsule synthesis protein
C5I45_02525	COG0791	NLP P60 protein
C5I45_02530	COG2433	Pfam Transposase IS66
C5I45_02535	COG0561	phosphatase activity
C5I45_02540	COG1316	TRANSCRIPTIONal
C5I45_02545	COG2814	Major facilitator Superfamily
C5I45_02550	COG1215	transferase activity, transferring glycosyl groups
C5I45_02560	COG0814	amino acid
C5I45_02565	COG0697	spore germination
C5I45_02570	COG1482	cell wall glycoprotein biosynthetic process
C5I45_02575	COG4193	domain, Protein
C5I45_02580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5I45_02585	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C5I45_02590	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5I45_02600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5I45_02605	COG1682	transport, permease protein
C5I45_02610	COG1134	teichoic acid transport
C5I45_02615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5I45_02620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C5I45_02625	COG1316	TRANSCRIPTIONal
C5I45_02635	COG2385	sporulation resulting in formation of a cellular spore
C5I45_02635	COG2247	cell wall binding repeat
C5I45_02640	COG2247	cell wall binding repeat
C5I45_02640	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5I45_02650	COG2244	polysaccharide biosynthetic process
C5I45_02655	COG0438	transferase activity, transferring glycosyl groups
C5I45_02655	COG0297	glycogen (starch) synthase activity
C5I45_02660	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5I45_02665	COG3307	-O-antigen
C5I45_02670	COG3206	protein involved in exopolysaccharide biosynthesis
C5I45_02675	COG1215	transferase activity, transferring glycosyl groups
C5I45_02680	COG0438	transferase activity, transferring glycosyl groups
C5I45_02685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5I45_02690	COG1316	TRANSCRIPTIONal
C5I45_02695	COG1739	Uncharacterized protein family UPF0029
C5I45_02700	COG4585	Histidine kinase
C5I45_02705	COG2197	response regulator
C5I45_02710	COG1307	EDD domain protein, DegV family
C5I45_02715	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C5I45_02725	COG1040	competence protein
C5I45_02735	COG2747	anti-sigma28 factor FlgM
C5I45_02740	COG3418	PFAM FlgN family protein
C5I45_02745	COG4786	Flagellar basal body rod
C5I45_02745	COG1256	bacterial-type flagellum assembly
C5I45_02750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5I45_02770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5I45_02775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5I45_02780	COG1516	flagellar protein fliS
C5I45_02795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5I45_02810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5I45_02815	COG2010	Cytochrome c
C5I45_02820	COG2884	Cell division ATP-binding protein ftsE
C5I45_02825	COG2177	Part of the ABC transporter FtsEX involved in
C5I45_02830	COG3420	alginic acid biosynthetic process
C5I45_02835	COG3409	Peptidoglycan-binding domain 1 protein
C5I45_02835	COG0793	Belongs to the peptidase S41A family
C5I45_02845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5I45_02880	COG2814	Major facilitator Superfamily
C5I45_02885	COG1309	transcriptional regulator
C5I45_02890	COG0574	Belongs to the PEP-utilizing enzyme family
C5I45_02890	COG3848	Pyruvate phosphate dikinase
C5I45_02895	COG4897	Protein conserved in bacteria
C5I45_02905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5I45_02920	COG3595	metallopeptidase activity
C5I45_02925	COG1983	PspC domain protein
C5I45_02930	COG1950	PFAM Membrane protein of
C5I45_02935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5I45_02940	COG1309	transcriptional regulator
C5I45_02955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5I45_02975	COG0110	maltose O-acetyltransferase activity
C5I45_02980	COG4990	cell redox homeostasis
C5I45_02995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5I45_03020	COG0140	phosphoribosyl-ATP diphosphatase activity
C5I45_03020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5I45_03025	COG1132	(ABC) transporter
C5I45_03035	COG0745	RESPONSE REGULATOR receiver
C5I45_03040	COG5002	protein histidine kinase activity
C5I45_03045	COG0457	Tetratricopeptide repeat
C5I45_03050	COG0791	NLP P60 protein
C5I45_03050	COG3883	PFAM NLP P60 protein
C5I45_03055	COG0492	ferredoxin-NADP+ reductase activity
C5I45_03060	COG1051	belongs to the nudix hydrolase family
C5I45_03070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5I45_03080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5I45_03085	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C5I45_03090	COG4290	ribonuclease
C5I45_03095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5I45_03105	COG0288	reversible hydration of carbon dioxide
C5I45_03110	COG0659	secondary active sulfate transmembrane transporter activity
C5I45_03115	COG1694	Mazg nucleotide pyrophosphohydrolase
C5I45_03120	COG1611	Belongs to the LOG family
C5I45_03125	COG0477	Major facilitator Superfamily
C5I45_03125	COG2814	Major facilitator Superfamily
C5I45_03130	COG2828	Protein conserved in bacteria
C5I45_03135	COG0583	DNA-binding transcription factor activity
C5I45_03145	COG1609	Transcriptional regulator
C5I45_03150	COG2223	nitrite transmembrane transporter activity
C5I45_03200	COG3479	Phenolic acid decarboxylase
C5I45_03205	COG0456	acetyltransferase
C5I45_03210	COG2364	Membrane
C5I45_03215	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5I45_03225	COG2272	Belongs to the type-B carboxylesterase lipase family
C5I45_03230	COG1396	sequence-specific DNA binding
C5I45_03235	COG3944	biosynthesis protein
C5I45_03240	COG0489	protein tyrosine kinase activity
C5I45_03245	COG1086	Polysaccharide biosynthesis protein
C5I45_03250	COG0438	transferase activity, transferring glycosyl groups
C5I45_03255	COG1215	transferase activity, transferring glycosyl groups
C5I45_03260	COG0438	transferase activity, transferring glycosyl groups
C5I45_03270	COG1216	Glycosyl transferase, family 2
C5I45_03275	COG5039	Polysaccharide pyruvyl transferase
C5I45_03280	COG1216	Glycosyl transferase, family 2
C5I45_03285	COG2244	polysaccharide biosynthetic process
C5I45_03290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5I45_03295	COG0110	maltose O-acetyltransferase activity
C5I45_03300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5I45_03305	COG5039	Polysaccharide pyruvyl transferase
C5I45_03315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5I45_03320	COG1620	l-lactate permease
C5I45_03325	COG2186	Transcriptional regulator
C5I45_03330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5I45_03355	COG1070	Carbohydrate kinase
C5I45_03360	COG1737	Transcriptional regulator
C5I45_03365	COG1113	amino acid transport
C5I45_03370	COG0697	spore germination
C5I45_03375	COG0583	DNA-binding transcription factor activity
C5I45_03385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5I45_03390	COG1609	Transcriptional regulator
C5I45_03395	COG2814	Major facilitator Superfamily
C5I45_03400	COG2390	Transcriptional regulator
C5I45_03405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5I45_03415	COG0126	phosphoglycerate kinase activity
C5I45_03435	COG2234	aminopeptidase activity
C5I45_03445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5I45_03450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_03455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5I45_03470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5I45_03485	COG0456	acetyltransferase
C5I45_03490	COG4640	response to antibiotic
C5I45_03495	COG3064	Membrane
C5I45_03505	COG2095	MarC family integral membrane protein
C5I45_03510	COG1510	regulation of RNA biosynthetic process
C5I45_03515	COG1125	glycine betaine transport
C5I45_03515	COG0517	IMP dehydrogenase activity
C5I45_03520	COG1174	glycine betaine transport
C5I45_03525	COG1732	Glycine betaine
C5I45_03530	COG1174	glycine betaine transport
C5I45_03535	COG1510	regulation of RNA biosynthetic process
C5I45_03540	COG1125	glycine betaine transport
C5I45_03540	COG0517	IMP dehydrogenase activity
C5I45_03545	COG1174	glycine betaine transport
C5I45_03550	COG1732	Glycine betaine
C5I45_03555	COG1174	glycine betaine transport
C5I45_03585	COG1733	regulation of RNA biosynthetic process
C5I45_03590	COG1396	sequence-specific DNA binding
C5I45_03595	COG1396	sequence-specific DNA binding
C5I45_03600	COG1476	TRANSCRIPTIONal
C5I45_03605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5I45_03610	COG1647	Serine aminopeptidase, S33
C5I45_03615	COG0557	exoribonuclease II activity
C5I45_03630	COG2732	(Barnase) inhibitor
C5I45_03635	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_03640	COG0583	DNA-binding transcription factor activity
C5I45_03645	COG0454	-acetyltransferase
C5I45_03650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5I45_03655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5I45_03660	COG0765	amino acid transport
C5I45_03665	COG0765	amino acid transport
C5I45_03670	COG1126	abc transporter atp-binding protein
C5I45_03675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5I45_03680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5I45_03685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5I45_03700	COG2814	Major facilitator Superfamily
C5I45_03720	COG0673	inositol 2-dehydrogenase activity
C5I45_03725	COG1937	Protein conserved in bacteria
C5I45_03730	COG2608	mercury ion transmembrane transporter activity
C5I45_03735	COG2217	Heavy metal translocating P-type atpase
C5I45_03740	COG2217	Heavy metal translocating P-type atpase
C5I45_03745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5I45_03750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C5I45_03760	COG2860	membrane
C5I45_03765	COG3973	AAA domain
C5I45_03770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5I45_03795	COG0656	L-ascorbic acid biosynthetic process
C5I45_03800	COG0842	Transport permease protein
C5I45_03810	COG1131	(ABC) transporter
C5I45_03815	COG3850	Histidine kinase
C5I45_03820	COG2197	response regulator
C5I45_03825	COG4149	molybdate abc transporter
C5I45_03830	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5I45_03835	COG1910	domain protein
C5I45_03840	COG1368	sulfuric ester hydrolase activity
C5I45_03845	COG1988	membrane-bound metal-dependent
C5I45_03860	COG0531	amino acid
C5I45_03865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C5I45_03870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5I45_03875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_03880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_03885	COG1120	ATPase activity
C5I45_03895	COG2140	Oxalate decarboxylase
C5I45_03905	COG1191	sigma factor activity
C5I45_03915	COG0745	RESPONSE REGULATOR receiver
C5I45_03920	COG2205	protein histidine kinase activity
C5I45_03925	COG3386	PFAM SMP-30 Gluconolaconase
C5I45_03930	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_03935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5I45_03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_03945	COG1120	ATPase activity
C5I45_03950	COG2096	Adenosyltransferase
C5I45_03955	COG2814	Major facilitator Superfamily
C5I45_03960	COG4758	membrane
C5I45_03965	COG1842	Phage shock protein A
C5I45_03970	COG3595	metallopeptidase activity
C5I45_03975	COG4758	membrane
C5I45_03980	COG4585	Histidine kinase
C5I45_03985	COG2197	response regulator
C5I45_03995	COG0814	amino acid
C5I45_04000	COG0697	spore germination
C5I45_04010	COG0114	fumarate hydratase activity
C5I45_04015	COG1309	transcriptional regulator
C5I45_04025	COG2205	protein histidine kinase activity
C5I45_04025	COG2770	Histidine kinase
C5I45_04030	COG0745	RESPONSE REGULATOR receiver
C5I45_04035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5I45_04040	COG0783	Belongs to the Dps family
C5I45_04045	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_04060	COG1120	ATPase activity
C5I45_04080	COG0583	DNA-binding transcription factor activity
C5I45_04085	COG0477	Major facilitator Superfamily
C5I45_04090	COG1846	Transcriptional regulator
C5I45_04095	COG5577	PFAM Coat F domain
C5I45_04115	COG1024	Enoyl-CoA hydratase
C5I45_04115	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5I45_04120	COG0183	Belongs to the thiolase family
C5I45_04125	COG1960	acyl-CoA dehydrogenase activity
C5I45_04130	COG1393	Belongs to the ArsC family
C5I45_04145	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C5I45_04150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_04160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5I45_04165	COG2011	ABC-type metal ion transport system permease component
C5I45_04170	COG1464	Belongs to the NlpA lipoprotein family
C5I45_04175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5I45_04185	COG0396	ATPase activity
C5I45_04190	COG0719	Fe-S assembly protein
C5I45_04195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5I45_04200	COG0822	iron-sulfur transferase activity
C5I45_04205	COG0719	Fe-S assembly protein
C5I45_04210	COG3409	Peptidoglycan-binding domain 1 protein
C5I45_04220	COG2226	methyltransferase
C5I45_04225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5I45_04230	COG0322	excinuclease ABC activity
C5I45_04245	COG0789	Transcriptional regulator
C5I45_04250	COG2222	sugar isomerase
C5I45_04255	COG1653	transport
C5I45_04260	COG1175	transmembrane transport
C5I45_04265	COG0395	ABC-type sugar transport system, permease component
C5I45_04270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5I45_04275	COG2188	Transcriptional regulator
C5I45_04280	COG3842	ATPase activity
C5I45_04285	COG2356	endonuclease I
C5I45_04290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5I45_04295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5I45_04300	COG2814	Major facilitator Superfamily
C5I45_04325	COG2508	Transcriptional regulator
C5I45_04340	COG1801	Protein of unknown function DUF72
C5I45_04345	COG0730	response to heat
C5I45_04350	COG0737	Belongs to the 5'-nucleotidase family
C5I45_04360	COG0739	heme binding
C5I45_04375	COG4470	Protein conserved in bacteria
C5I45_04380	COG2445	Protein of unknown function DUF86
C5I45_04385	COG0647	UMP catabolic process
C5I45_04390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C5I45_04395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5I45_04400	COG0460	homoserine dehydrogenase
C5I45_04405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5I45_04415	COG0823	Involved in the tonB-independent uptake of proteins
C5I45_04415	COG1506	peptidase
C5I45_04415	COG4946	Tricorn protease homolog
C5I45_04420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5I45_04425	COG4837	Protein of unknown function (DUF1462)
C5I45_04430	COG1252	NADH dehydrogenase
C5I45_04440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5I45_04450	COG0316	Belongs to the HesB IscA family
C5I45_04455	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C5I45_04480	COG1131	(ABC) transporter
C5I45_04510	COG1252	NADH dehydrogenase
C5I45_04525	COG3584	3D domain protein
C5I45_04530	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C5I45_04540	COG2056	Na+-H+ antiporter family
C5I45_04545	COG1268	BioY protein
C5I45_04550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5I45_04555	COG2819	hydrolase of the alpha beta superfamily
C5I45_04560	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_04565	COG1169	isochorismate synthase
C5I45_04570	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5I45_04575	COG1535	isochorismatase
C5I45_04575	COG3433	isochorismatase activity
C5I45_04580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_04585	COG3251	PFAM MbtH domain protein
C5I45_04590	COG5634	Uncharacterized conserved protein (DUF2278)
C5I45_04595	COG0686	Belongs to the AlaDH PNT family
C5I45_04600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C5I45_04600	COG2508	Transcriptional regulator
C5I45_04610	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_04615	COG1418	mRNA catabolic process
C5I45_04625	COG0628	permease
C5I45_04640	COG5506	Protein of unknown function (DUF1694)
C5I45_04645	COG1335	isochorismatase
C5I45_04650	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5I45_04655	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C5I45_04680	COG4585	Histidine kinase
C5I45_04685	COG2197	response regulator
C5I45_04690	COG2050	protein possibly involved in aromatic compounds catabolism
C5I45_04695	COG1320	monovalent cation:proton antiporter activity
C5I45_04700	COG2212	antiporter activity
C5I45_04705	COG1863	multisubunit Na H antiporter MnhE subunit
C5I45_04710	COG0651	ATP synthesis coupled electron transport
C5I45_04715	COG1006	Multisubunit Na H antiporter MnhC subunit
C5I45_04720	COG2111	Na H antiporter
C5I45_04725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5I45_04725	COG2111	Na H antiporter
C5I45_04755	COG4565	transcriptional regulatory protein
C5I45_04760	COG3290	protein histidine kinase activity
C5I45_04770	COG3011	Protein conserved in bacteria
C5I45_04775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5I45_04780	COG2814	Major facilitator Superfamily
C5I45_04785	COG5018	Exonuclease
C5I45_04795	COG2205	protein histidine kinase activity
C5I45_04800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5I45_04810	COG2267	carboxylic ester hydrolase activity
C5I45_04815	COG1522	sequence-specific DNA binding
C5I45_04820	COG0436	Aminotransferase
C5I45_04825	COG1098	S1 RNA binding domain
C5I45_04830	COG2155	Conserved Protein
C5I45_04835	COG1979	alcohol dehydrogenase
C5I45_04840	COG1979	alcohol dehydrogenase
C5I45_04850	COG1335	isochorismatase
C5I45_04880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5I45_04895	COG2738	Putative neutral zinc metallopeptidase
C5I45_04900	COG1253	flavin adenine dinucleotide binding
C5I45_04905	COG0366	Alpha amylase catalytic
C5I45_04910	COG0432	Pfam Uncharacterised protein family UPF0047
C5I45_04915	COG2070	2-Nitropropane dioxygenase
C5I45_04930	COG0840	transmembrane signaling receptor activity
C5I45_04935	COG0840	transmembrane signaling receptor activity
C5I45_04940	COG0840	transmembrane signaling receptor activity
C5I45_04945	COG0840	transmembrane signaling receptor activity
C5I45_04950	COG0693	protein deglycase activity
C5I45_04955	COG0673	inositol 2-dehydrogenase activity
C5I45_04960	COG0628	permease
C5I45_05015	COG1017	nitric oxide dioxygenase activity
C5I45_05015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5I45_05020	COG1705	Flagellar rod assembly protein muramidase FlgJ
C5I45_05025	COG0569	domain protein
C5I45_05035	COG1510	regulation of RNA biosynthetic process
C5I45_05045	COG1454	alcohol dehydrogenase
C5I45_05055	COG2318	DinB family
C5I45_05060	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5I45_05065	COG2268	Band 7 protein
C5I45_05070	COG3859	Proton-coupled thiamine transporter YuaJ
C5I45_05195	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C5I45_05200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5I45_05205	COG1169	isochorismate synthase
C5I45_05215	COG0596	Alpha beta hydrolase
C5I45_05220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C5I45_05230	COG4948	Mandelate Racemase Muconate Lactonizing
C5I45_05245	COG1294	oxidase, subunit
C5I45_05250	COG1271	oxidase subunit
C5I45_05260	COG0288	reversible hydration of carbon dioxide
C5I45_05285	COG0783	Belongs to the Dps family
C5I45_05290	COG4824	toxin secretion phage lysis holin
C5I45_05295	COG0494	nUDIX hydrolase
C5I45_05300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5I45_05305	COG1116	anion transmembrane transporter activity
C5I45_05310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5I45_05315	COG1506	peptidase
C5I45_05335	COG0367	asparagine synthase
C5I45_05340	COG1113	amino acid transport
C5I45_05345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5I45_05350	COG2267	carboxylic ester hydrolase activity
C5I45_05360	COG0584	glycerophosphoryl diester phosphodiesterase
C5I45_05370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C5I45_05375	COG1242	4 iron, 4 sulfur cluster binding
C5I45_05380	COG0477	Major facilitator Superfamily
C5I45_05395	COG1725	Transcriptional regulator
C5I45_05400	COG1131	(ABC) transporter
C5I45_05420	COG1136	(ABC) transporter
C5I45_05425	COG0577	efflux transmembrane transporter activity
C5I45_05430	COG0745	RESPONSE REGULATOR receiver
C5I45_05435	COG2205	protein histidine kinase activity
C5I45_05440	COG1136	(ABC) transporter
C5I45_05445	COG0577	efflux transmembrane transporter activity
C5I45_05450	COG5522	Integral membrane protein (intg_mem_TP0381)
C5I45_05455	COG2814	Major facilitator Superfamily
C5I45_05460	COG2202	Pas domain
C5I45_05460	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_05475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5I45_05485	COG1486	melibiose metabolic process
C5I45_05515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5I45_05520	COG2081	HI0933 family
C5I45_05525	COG2244	polysaccharide biosynthetic process
C5I45_05530	COG1187	pseudouridine synthase activity
C5I45_05535	COG1349	DNA-binding transcription factor activity
C5I45_05545	COG1131	(ABC) transporter
C5I45_05550	COG4473	ABC transporter
C5I45_05555	COG2252	PERMEase
C5I45_05560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5I45_05565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5I45_05570	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C5I45_05580	COG1597	lipid kinase activity
C5I45_05585	COG0510	thiamine kinase activity
C5I45_05600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5I45_05605	COG0281	malic enzyme
C5I45_05610	COG5584	Small secreted protein
C5I45_05615	COG1363	Peptidase, m42
C5I45_05625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_05635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5I45_05640	COG1674	ftsk spoiiie
C5I45_05650	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C5I45_05655	COG4980	gas vesicle protein
C5I45_05660	COG3118	belongs to the thioredoxin family
C5I45_05665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C5I45_05665	COG1605	Chorismate mutase
C5I45_05670	COG1609	Transcriptional regulator
C5I45_05675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C5I45_05680	COG1360	Flagellar Motor Protein
C5I45_05685	COG0123	including yeast histone deacetylase and acetoin utilization protein
C5I45_05690	COG0517	IMP dehydrogenase activity
C5I45_05695	COG0454	-acetyltransferase
C5I45_05700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5I45_05725	COG1378	Sugar-specific transcriptional regulator TrmB
C5I45_05730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5I45_05755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5I45_05755	COG1017	nitric oxide dioxygenase activity
C5I45_05795	COG4282	regulation of fungal-type cell wall biogenesis
C5I45_05800	COG1012	belongs to the aldehyde dehydrogenase family
C5I45_05815	COG2203	Gaf domain
C5I45_05815	COG2199	diguanylate cyclase activity
C5I45_05820	COG1956	GAF domain-containing protein
C5I45_05825	COG1309	transcriptional regulator
C5I45_05830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5I45_05840	COG1114	Component of the transport system for branched-chain amino acids
C5I45_05845	COG1104	cysteine desulfurase activity
C5I45_05860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5I45_05865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C5I45_05870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5I45_05875	COG0616	signal peptide processing
C5I45_05880	COG1714	RDD family
C5I45_05890	COG3874	Sporulation protein YtfJ
C5I45_05895	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C5I45_05900	COG0827	DNA restriction-modification system
C5I45_05910	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5I45_05925	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_05935	COG4109	DRTGG domain
C5I45_05945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5I45_05965	COG0587	DNA-directed DNA polymerase activity
C5I45_05970	COG0281	malic enzyme
C5I45_05990	COG0469	pyruvate kinase activity
C5I45_05995	COG3030	protein affecting phage T7 exclusion by the F plasmid
C5I45_06000	COG0628	permease
C5I45_06030	COG0457	Tetratricopeptide repeat
C5I45_06035	COG0372	Belongs to the citrate synthase family
C5I45_06040	COG0538	isocitrate dehydrogenase activity
C5I45_06050	COG0745	RESPONSE REGULATOR receiver
C5I45_06055	COG5002	protein histidine kinase activity
C5I45_06060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5I45_06060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5I45_06065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5I45_06070	COG1971	Probably functions as a manganese efflux pump
C5I45_06075	COG0237	dephospho-CoA kinase activity
C5I45_06080	COG0656	L-ascorbic acid biosynthetic process
C5I45_06085	COG2814	Major facilitator Superfamily
C5I45_06090	COG1733	regulation of RNA biosynthetic process
C5I45_06095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5I45_06110	COG3611	Membrane attachment protein
C5I45_06115	COG1484	DNA-dependent DNA replication
C5I45_06120	COG0398	Pfam SNARE associated Golgi protein
C5I45_06140	COG3275	phosphorelay sensor kinase activity
C5I45_06145	COG3279	Response regulator of the LytR AlgR family
C5I45_06150	COG1380	Effector of murein hydrolase LrgA
C5I45_06155	COG1346	cytolysis
C5I45_06160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5I45_06170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5I45_06175	COG3326	Membrane
C5I45_06185	COG1363	Peptidase, m42
C5I45_06190	COG3507	Belongs to the glycosyl hydrolase 43 family
C5I45_06195	COG2160	L-arabinose isomerase activity
C5I45_06200	COG1069	ribulokinase activity
C5I45_06205	COG0235	Class ii aldolase
C5I45_06210	COG0647	UMP catabolic process
C5I45_06220	COG1653	transport
C5I45_06225	COG1175	transmembrane transport
C5I45_06230	COG0395	ABC-type sugar transport system, permease component
C5I45_06235	COG3534	alpha-L-arabinofuranosidase
C5I45_06240	COG1966	Carbon starvation protein
C5I45_06245	COG0247	lactate metabolic process
C5I45_06250	COG0277	FAD linked oxidase domain protein
C5I45_06255	COG3835	regulator
C5I45_06265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5I45_06270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5I45_06275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5I45_06275	COG0072	phenylalanine-tRNA ligase activity
C5I45_06290	COG1286	toxin biosynthetic process
C5I45_06295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5I45_06295	COG1796	DNA polymerase
C5I45_06305	COG3766	membrane
C5I45_06315	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_06320	COG1309	transcriptional regulator
C5I45_06325	COG1024	Enoyl-CoA hydratase
C5I45_06330	COG2086	electron transfer activity
C5I45_06335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5I45_06340	COG3534	alpha-L-arabinofuranosidase
C5I45_06345	COG3118	belongs to the thioredoxin family
C5I45_06360	COG0527	aspartate kinase activity
C5I45_06365	COG1719	4-vinyl reductase, 4VR
C5I45_06370	COG2009	succinate dehydrogenase
C5I45_06375	COG1053	succinate dehydrogenase
C5I45_06380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5I45_06385	COG0824	Thioesterase
C5I45_06390	COG2197	response regulator
C5I45_06395	COG1846	Transcriptional regulator
C5I45_06405	COG5401	PFAM Sporulation and spore germination
C5I45_06415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5I45_06420	COG0622	Phosphoesterase
C5I45_06440	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C5I45_06485	COG0028	Belongs to the TPP enzyme family
C5I45_06490	COG0440	acetolactate synthase activity
C5I45_06505	COG0473	3-isopropylmalate dehydrogenase activity
C5I45_06520	COG1477	protein flavinylation
C5I45_06520	COG0457	Tetratricopeptide repeat
C5I45_06535	COG1067	ATP-dependent peptidase activity
C5I45_06535	COG0470	DNA polymerase III
C5I45_06540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5I45_06560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5I45_06570	COG1587	Uroporphyrinogen-III synthase
C5I45_06575	COG0113	porphobilinogen synthase activity
C5I45_06585	COG1388	LysM domain
C5I45_06590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5I45_06600	COG0525	valine-tRNA ligase activity
C5I45_06605	COG0285	dihydrofolate synthase activity
C5I45_06610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C5I45_06630	COG1077	Cell shape determining protein MreB Mrl
C5I45_06635	COG1792	Involved in formation and maintenance of cell shape
C5I45_06640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C5I45_06650	COG2894	cell division
C5I45_06655	COG0739	heme binding
C5I45_06660	COG1994	Peptidase M50
C5I45_06670	COG2868	ribosomal protein
C5I45_06675	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5I45_06680	COG3290	protein histidine kinase activity
C5I45_06695	COG0077	Prephenate dehydratase
C5I45_06700	COG1827	regulation of RNA biosynthetic process
C5I45_06705	COG1104	cysteine desulfurase activity
C5I45_06710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5I45_06715	COG0157	Belongs to the NadC ModD family
C5I45_06725	COG1388	LysM domain
C5I45_06770	COG1862	Preprotein translocase
C5I45_06780	COG2323	membrane
C5I45_06785	COG2244	polysaccharide biosynthetic process
C5I45_06795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5I45_06795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5I45_06800	COG0490	domain, Protein
C5I45_06805	COG5416	Lipopolysaccharide assembly protein A domain
C5I45_06810	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5I45_06810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5I45_06820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5I45_06830	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5I45_06830	COG3103	Sh3 type 3 domain protein
C5I45_06830	COG4991	sh3 domain protein
C5I45_06850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5I45_06855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5I45_06860	COG1959	2 iron, 2 sulfur cluster binding
C5I45_06865	COG1104	cysteine desulfurase activity
C5I45_06875	COG0457	Tetratricopeptide repeat
C5I45_06880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5I45_06885	COG3881	PFAM PRC-barrel domain
C5I45_06900	COG0765	amino acid transport
C5I45_06905	COG0765	amino acid transport
C5I45_06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5I45_06915	COG1126	abc transporter atp-binding protein
C5I45_06920	COG0628	permease
C5I45_06930	COG4472	Bacterial protein of unknown function (DUF965)
C5I45_06945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5I45_06975	COG0768	penicillin binding
C5I45_07000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5I45_07005	COG0626	cystathionine gamma-synthase activity
C5I45_07015	COG2427	Protein of unknown function (DUF1641)
C5I45_07020	COG3383	formate dehydrogenase (NAD+) activity
C5I45_07025	COG5609	conserved protein (DUF2294)
C5I45_07030	COG2116	formate transmembrane transporter activity
C5I45_07045	COG2226	methyltransferase
C5I45_07050	COG1309	transcriptional regulator
C5I45_07055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5I45_07055	COG2124	cytochrome p450
C5I45_07060	COG2814	Major facilitator Superfamily
C5I45_07065	COG0583	DNA-binding transcription factor activity
C5I45_07070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5I45_07080	COG3711	transcriptional antiterminator
C5I45_07080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5I45_07085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5I45_07085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5I45_07085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5I45_07090	COG1482	cell wall glycoprotein biosynthetic process
C5I45_07100	COG0561	phosphatase activity
C5I45_07105	COG0561	phosphatase activity
C5I45_07115	COG2318	DinB family
C5I45_07120	COG0456	acetyltransferase
C5I45_07125	COG2814	Major facilitator Superfamily
C5I45_07135	COG0563	adenylate kinase activity
C5I45_07145	COG2207	Transcriptional regulator
C5I45_07145	COG3708	Transcriptional regulator
C5I45_07175	COG0398	Pfam SNARE associated Golgi protein
C5I45_07180	COG0726	polysaccharide deacetylase
C5I45_07185	COG2755	lipolytic protein G-D-S-L family
C5I45_07195	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C5I45_07200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C5I45_07205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5I45_07210	COG1534	Rna-binding protein
C5I45_07220	COG1713	HD superfamily hydrolase involved in NAD metabolism
C5I45_07225	COG0799	negative regulation of ribosome biogenesis
C5I45_07230	COG2226	methyltransferase
C5I45_07235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5I45_07240	COG1596	polysaccharide export
C5I45_07240	COG1555	photosystem II stabilization
C5I45_07245	COG2131	deaminase
C5I45_07250	COG0658	competence protein
C5I45_07250	COG2333	competence protein COMEC
C5I45_07260	COG1466	dna polymerase III delta subunit
C5I45_07275	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5I45_07290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5I45_07320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5I45_07325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5I45_07330	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5I45_07335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5I45_07340	COG1610	YqeY-like protein
C5I45_07345	COG1030	water channel activity
C5I45_07350	COG4864	UPF0365 protein
C5I45_07365	COG0561	phosphatase activity
C5I45_07370	COG1702	phosphate starvation-inducible protein PhoH
C5I45_07375	COG1480	7TM receptor with intracellular HD hydrolase
C5I45_07385	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C5I45_07390	COG0295	cytidine deaminase activity
C5I45_07395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5I45_07415	COG0751	glycine-tRNA ligase activity
C5I45_07420	COG0517	IMP dehydrogenase activity
C5I45_07435	COG0358	DNA primase activity
C5I45_07440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5I45_07445	COG2010	Cytochrome c
C5I45_07450	COG2384	SAM-dependent methyltransferase
C5I45_07455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5I45_07470	COG0513	Belongs to the DEAD box helicase family
C5I45_07485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5I45_07490	COG0735	belongs to the Fur family
C5I45_07495	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C5I45_07500	COG4709	membrane
C5I45_07510	COG1388	LysM domain
C5I45_07515	COG5521	maltodextrose utilization protein MalA
C5I45_07520	COG2839	Protein conserved in bacteria
C5I45_07525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5I45_07530	COG0477	Major facilitator Superfamily
C5I45_07540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5I45_07545	COG0573	inorganic phosphate transmembrane transporter activity
C5I45_07550	COG0581	inorganic phosphate transmembrane transporter activity
C5I45_07555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5I45_07560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5I45_07565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5I45_07575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5I45_07580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5I45_07590	COG1757	Na H antiporter
C5I45_07595	COG4483	Protein conserved in bacteria
C5I45_07600	COG1940	carbohydrate kinase activity
C5I45_07605	COG2866	Carboxypeptidase
C5I45_07615	COG0011	TIGRFAM Protein of
C5I45_07625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5I45_07635	COG1393	Belongs to the ArsC family
C5I45_07645	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_07650	COG1253	flavin adenine dinucleotide binding
C5I45_07655	COG0598	Magnesium transport protein CorA
C5I45_07660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5I45_07665	COG1459	type II secretion system
C5I45_07670	COG4537	Required for transformation and DNA binding
C5I45_07675	COG4970	Tfp pilus assembly protein FimT
C5I45_07685	COG4940	Competence protein ComGF
C5I45_07710	COG0681	Belongs to the peptidase S26 family
C5I45_07720	COG1396	sequence-specific DNA binding
C5I45_07735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5I45_07755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5I45_07770	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5I45_07780	COG3872	metal-dependent enzyme
C5I45_07790	COG0006	proline dipeptidase activity
C5I45_07805	COG3854	ATPases associated with a variety of cellular activities
C5I45_07845	COG0511	ligase activity, forming carbon-carbon bonds
C5I45_07850	COG0439	Biotin carboxylase
C5I45_07855	COG1302	Protein conserved in bacteria
C5I45_07870	COG1570	exodeoxyribonuclease VII activity
C5I45_07880	COG0142	geranyltranstransferase activity
C5I45_07890	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C5I45_07900	COG0497	DNA recombination
C5I45_07905	COG0750	zinc metalloprotease
C5I45_07910	COG0745	RESPONSE REGULATOR receiver
C5I45_07920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5I45_07935	COG1902	pentaerythritol trinitrate reductase activity
C5I45_07955	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5I45_07960	COG0584	glycerophosphoryl diester phosphodiesterase
C5I45_07965	COG0183	Belongs to the thiolase family
C5I45_07970	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5I45_07975	COG1960	acyl-CoA dehydrogenase activity
C5I45_07980	COG0372	Belongs to the citrate synthase family
C5I45_07985	COG2079	MmgE PrpD family protein
C5I45_07990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5I45_08000	COG3829	transcription factor binding
C5I45_08000	COG3290	protein histidine kinase activity
C5I45_08005	COG0280	phosphate acetyltransferase
C5I45_08010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5I45_08015	COG3426	butyrate kinase activity
C5I45_08020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5I45_08025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5I45_08030	COG0022	dehydrogenase e1 component
C5I45_08035	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5I45_08040	COG1597	lipid kinase activity
C5I45_08050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5I45_08055	COG0765	amino acid transport
C5I45_08060	COG1126	abc transporter atp-binding protein
C5I45_08065	COG4129	membrane
C5I45_08070	COG1376	ErfK ybiS ycfS ynhG family protein
C5I45_08075	COG0346	lactoylglutathione lyase activity
C5I45_08080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5I45_08085	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5I45_08090	COG0706	membrane insertase activity
C5I45_08105	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5I45_08110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5I45_08125	COG0596	Alpha beta hydrolase
C5I45_08150	COG0250	Participates in transcription elongation, termination and antitermination
C5I45_08160	COG2070	2-Nitropropane dioxygenase
C5I45_08160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5I45_08175	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_08180	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08185	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_08185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_08185	COG3321	synthase
C5I45_08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_08190	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08190	COG3321	synthase
C5I45_08190	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_08190	COG0300	oxidoreductase activity
C5I45_08190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_08195	COG3321	synthase
C5I45_08195	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_08195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_08195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_08200	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_08200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_08200	COG3321	synthase
C5I45_08200	COG0300	oxidoreductase activity
C5I45_08200	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08205	COG3321	synthase
C5I45_08205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_08205	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_08205	COG0300	oxidoreductase activity
C5I45_08205	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_08210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_08210	COG3321	synthase
C5I45_08210	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_08215	COG3321	synthase
C5I45_08215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_08215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_08215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_08215	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_08220	COG2124	cytochrome p450
C5I45_08225	COG3425	synthase
C5I45_08230	COG1024	Enoyl-CoA hydratase
C5I45_08235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5I45_08240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5I45_08245	COG0300	oxidoreductase activity
C5I45_08250	COG3048	D-serine ammonia-lyase activity
C5I45_08260	COG0346	lactoylglutathione lyase activity
C5I45_08270	COG0628	permease
C5I45_08285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5I45_08290	COG0456	acetyltransferase
C5I45_08295	COG2329	Antibiotic biosynthesis monooxygenase
C5I45_08300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5I45_08300	COG0456	acetyltransferase
C5I45_08305	COG4918	Iron-sulphur cluster biosynthesis
C5I45_08315	COG1073	alpha beta
C5I45_08325	COG0667	Aldo Keto reductase
C5I45_08335	COG0494	nUDIX hydrolase
C5I45_08340	COG1379	DNA repair
C5I45_08345	COG1396	sequence-specific DNA binding
C5I45_08350	COG0252	asparaginase activity
C5I45_08355	COG1027	Aspartate ammonia-lyase
C5I45_08360	COG1757	Na H antiporter
C5I45_08365	COG0281	malic enzyme
C5I45_08380	COG1300	Membrane
C5I45_08385	COG0735	belongs to the Fur family
C5I45_08395	COG4974	Belongs to the 'phage' integrase family
C5I45_08400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C5I45_08405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C5I45_08410	COG1686	Belongs to the peptidase S11 family
C5I45_08415	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_08425	COG1191	sigma factor activity
C5I45_08445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5I45_08460	COG0697	spore germination
C5I45_08465	COG0019	diaminopimelate decarboxylase activity
C5I45_08470	COG4086	secreted protein
C5I45_08475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5I45_08485	COG0681	Belongs to the peptidase S26 family
C5I45_08495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5I45_08495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5I45_08500	COG0307	riboflavin synthase, alpha
C5I45_08515	COG0456	acetyltransferase
C5I45_08525	COG1547	Domain of unknown function (DUF309)
C5I45_08550	COG1686	Belongs to the peptidase S11 family
C5I45_08555	COG2715	membrane protein required for spore maturation
C5I45_08560	COG0700	Nucleoside recognition
C5I45_08565	COG1187	pseudouridine synthase activity
C5I45_08570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_08575	COG1333	cytochrome c biogenesis protein
C5I45_08580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5I45_08585	COG0745	RESPONSE REGULATOR receiver
C5I45_08590	COG5002	protein histidine kinase activity
C5I45_08595	COG1595	DNA-templated transcription, initiation
C5I45_08605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5I45_08610	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C5I45_08615	COG1141	Ferredoxin
C5I45_08620	COG4955	Helix-turn-helix domain
C5I45_08625	COG0514	ATP-dependent DNA helicase (RecQ)
C5I45_08630	COG1266	CAAX protease self-immunity
C5I45_08635	COG1388	LysM domain
C5I45_08645	COG1408	metallophosphoesterase
C5I45_08650	COG4862	establishment of competence for transformation
C5I45_08655	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5I45_08660	COG0492	ferredoxin-NADP+ reductase activity
C5I45_08665	COG2339	peptidase activity
C5I45_08670	COG3409	Peptidoglycan-binding domain 1 protein
C5I45_08670	COG3773	Cell wall hydrolase
C5I45_08675	COG2959	enzyme of heme biosynthesis
C5I45_08680	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C5I45_08690	COG0539	negative regulation of cytoplasmic translation
C5I45_08730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C5I45_08735	COG0776	regulation of translation
C5I45_08750	COG0142	geranyltranstransferase activity
C5I45_08760	COG0142	geranyltranstransferase activity
C5I45_08765	COG0105	UTP biosynthetic process
C5I45_08770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5I45_08785	COG4401	Chorismate mutase type I
C5I45_08790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5I45_08825	COG0287	Prephenate dehydrogenase
C5I45_08835	COG0457	Tetratricopeptide repeat
C5I45_08850	COG0723	plastoquinol--plastocyanin reductase activity
C5I45_08855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5I45_08860	COG2010	Cytochrome c
C5I45_08860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5I45_08865	COG4347	Protein of unknown function (DUF1405)
C5I45_08875	COG2140	Oxalate decarboxylase
C5I45_08880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5I45_08885	COG1694	Mazg nucleotide pyrophosphohydrolase
C5I45_08900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5I45_08905	COG0438	transferase activity, transferring glycosyl groups
C5I45_08935	COG1199	ATP-dependent helicase activity
C5I45_08935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5I45_08945	COG5353	protein conserved in bacteria
C5I45_08950	COG0436	Aminotransferase
C5I45_08960	COG3935	DnaD domain protein
C5I45_08965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5I45_08975	COG4499	WXG100 protein secretion system (Wss), protein YukC
C5I45_08975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5I45_09015	COG0071	Belongs to the small heat shock protein (HSP20) family
C5I45_09020	COG2190	(PTS) system
C5I45_09025	COG1205	dead DEAH box helicase
C5I45_09025	COG1111	helicase
C5I45_09030	COG3359	exonuclease
C5I45_09055	COG0116	Belongs to the methyltransferase superfamily
C5I45_09070	COG1199	ATP-dependent helicase activity
C5I45_09075	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C5I45_09085	COG2233	PERMEase
C5I45_09095	COG1335	isochorismatase
C5I45_09120	COG3424	synthase
C5I45_09125	COG1755	Isoprenylcysteine carboxyl methyltransferase
C5I45_09135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C5I45_09150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5I45_09160	COG0328	RNA-DNA hybrid ribonuclease activity
C5I45_09165	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C5I45_09170	COG0328	RNA-DNA hybrid ribonuclease activity
C5I45_09190	COG1278	Cold shock
C5I45_09195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5I45_09205	COG0386	Belongs to the glutathione peroxidase family
C5I45_09210	COG1418	mRNA catabolic process
C5I45_09215	COG1413	lyase activity
C5I45_09230	COG2136	Putative SAM-dependent methyltransferase
C5I45_09230	COG2521	methyltransferase
C5I45_09245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5I45_09250	COG0204	Acyl-transferase
C5I45_09255	COG1272	protein, Hemolysin III
C5I45_09260	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C5I45_09265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5I45_09275	COG1999	signal sequence binding
C5I45_09280	COG2755	lipolytic protein G-D-S-L family
C5I45_09285	COG4698	Protein conserved in bacteria
C5I45_09290	COG1846	Transcriptional regulator
C5I45_09310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5I45_09330	COG1525	nuclease
C5I45_09335	COG4282	regulation of fungal-type cell wall biogenesis
C5I45_09340	COG5444	nuclease activity
C5I45_09385	COG0457	Tetratricopeptide repeat
C5I45_09390	COG1388	LysM domain
C5I45_09405	COG1793	dna ligase
C5I45_09445	COG1086	Polysaccharide biosynthesis protein
C5I45_09455	COG4641	Protein conserved in bacteria
C5I45_09470	COG0463	Glycosyl transferase, family 2
C5I45_09475	COG0456	acetyltransferase
C5I45_09485	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C5I45_09490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5I45_09495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5I45_09500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5I45_09505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5I45_09510	COG0456	acetyltransferase
C5I45_09515	COG1509	lysine 2,3-aminomutase activity
C5I45_09550	COG0671	phosphoesterase, PA-phosphatase related
C5I45_09570	COG1876	peptidase activity
C5I45_09580	COG2226	methyltransferase
C5I45_09585	COG0793	Belongs to the peptidase S41A family
C5I45_09585	COG3409	Peptidoglycan-binding domain 1 protein
C5I45_09590	COG2188	Transcriptional regulator
C5I45_09595	COG2723	6-phospho-beta-galactosidase activity
C5I45_09605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5I45_09615	COG0346	lactoylglutathione lyase activity
C5I45_09620	COG0400	carboxylic ester hydrolase activity
C5I45_09625	COG0778	Nitroreductase
C5I45_09630	COG1733	regulation of RNA biosynthetic process
C5I45_09640	COG1942	4-Oxalocrotonate Tautomerase
C5I45_09655	COG2962	Rard protein
C5I45_09665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5I45_09670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5I45_09675	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_09680	COG0534	Mate efflux family protein
C5I45_09685	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5I45_09690	COG1819	glycosyl
C5I45_09695	COG1388	LysM domain
C5I45_09695	COG0791	NLP P60 protein
C5I45_09700	COG2032	superoxide dismutase activity
C5I45_09705	COG0714	Associated with various cellular activities
C5I45_09710	COG4548	von Willebrand factor, type A
C5I45_09720	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5I45_09725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5I45_09730	COG0385	Bile acid
C5I45_09735	COG0733	neurotransmitter:sodium symporter activity
C5I45_09740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5I45_09745	COG1657	PFAM Prenyltransferase squalene oxidase
C5I45_09750	COG1012	belongs to the aldehyde dehydrogenase family
C5I45_09780	COG0071	Belongs to the small heat shock protein (HSP20) family
C5I45_09795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5I45_09800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5I45_09810	COG0514	ATP-dependent DNA helicase (RecQ)
C5I45_09815	COG3584	3D domain protein
C5I45_09815	COG1388	LysM domain
C5I45_09825	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5I45_09840	COG2322	membrane
C5I45_09845	COG0741	lytic transglycosylase activity
C5I45_09850	COG0640	Transcriptional regulator
C5I45_09860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5I45_09865	COG1309	transcriptional regulator
C5I45_09870	COG2207	Transcriptional regulator
C5I45_09870	COG0662	Cupin 2, conserved barrel domain protein
C5I45_09875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5I45_09880	COG1733	regulation of RNA biosynthetic process
C5I45_09885	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_09920	COG3220	belongs to the UPF0276 family
C5I45_10005	COG0243	molybdopterin cofactor binding
C5I45_10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5I45_10015	COG1070	Carbohydrate kinase
C5I45_10020	COG2814	Major facilitator Superfamily
C5I45_10030	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C5I45_10035	COG0300	oxidoreductase activity
C5I45_10050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5I45_10055	COG0583	DNA-binding transcription factor activity
C5I45_10060	COG0069	glutamate synthase activity
C5I45_10060	COG0070	glutamate synthase
C5I45_10060	COG0067	glutamate synthase
C5I45_10065	COG0493	'glutamate synthase
C5I45_10075	COG0604	alcohol dehydrogenase
C5I45_10090	COG0640	Transcriptional regulator
C5I45_10095	COG2814	Major facilitator Superfamily
C5I45_10100	COG0405	Gamma-glutamyltransferase
C5I45_10105	COG0166	Belongs to the GPI family
C5I45_10110	COG0582	viral genome integration into host DNA
C5I45_10125	COG0534	Mate efflux family protein
C5I45_10130	COG2017	converts alpha-aldose to the beta-anomer
C5I45_10135	COG2027	D-alanyl-D-alanine carboxypeptidase
C5I45_10150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_10160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_10165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_10165	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C5I45_10175	COG1649	PFAM Uncharacterised BCR, COG1649
C5I45_10180	COG1960	acyl-CoA dehydrogenase activity
C5I45_10185	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_10190	COG0439	Biotin carboxylase
C5I45_10195	COG0511	ligase activity, forming carbon-carbon bonds
C5I45_10200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5I45_10205	COG1024	Enoyl-CoA hydratase
C5I45_10210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5I45_10215	COG0586	Pfam SNARE associated Golgi protein
C5I45_10220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5I45_10225	COG2246	polysaccharide biosynthetic process
C5I45_10235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5I45_10250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5I45_10255	COG2124	cytochrome p450
C5I45_10260	COG2610	gluconate transmembrane transporter activity
C5I45_10265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5I45_10270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5I45_10275	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_10305	COG3507	Belongs to the glycosyl hydrolase 43 family
C5I45_10315	COG0745	RESPONSE REGULATOR receiver
C5I45_10320	COG2205	protein histidine kinase activity
C5I45_10370	COG2271	Major facilitator Superfamily
C5I45_10375	COG1609	Transcriptional regulator
C5I45_10380	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_10385	COG1312	Catalyzes the dehydration of D-mannonate
C5I45_10390	COG0800	Aldolase
C5I45_10395	COG1063	alcohol dehydrogenase
C5I45_10405	COG1115	amino acid carrier protein
C5I45_10415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5I45_10420	COG0187	DNA topoisomerase II activity
C5I45_10425	COG1832	CoA-binding protein
C5I45_10435	COG4841	protein insertion into membrane
C5I45_10445	COG0824	Thioesterase
C5I45_10465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_10470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5I45_10485	COG0071	Belongs to the small heat shock protein (HSP20) family
C5I45_10495	COG4846	Membrane protein involved in cytochrome C biogenesis
C5I45_10500	COG2201	protein-glutamate methylesterase activity
C5I45_10505	COG0785	Cytochrome C biogenesis protein
C5I45_10525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5I45_10535	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5I45_10565	COG4195	phage-related replication protein
C5I45_10570	COG0756	dUTP diphosphatase activity
C5I45_10580	COG5434	Belongs to the glycosyl hydrolase 28 family
C5I45_10595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5I45_10605	COG3397	chitin binding
C5I45_10655	COG1064	alcohol dehydrogenase
C5I45_10660	COG2318	DinB family
C5I45_10665	COG2378	regulation of single-species biofilm formation
C5I45_10685	COG0574	Belongs to the PEP-utilizing enzyme family
C5I45_10685	COG3848	Pyruvate phosphate dikinase
C5I45_10690	COG1070	Carbohydrate kinase
C5I45_10705	COG3507	Belongs to the glycosyl hydrolase 43 family
C5I45_10710	COG2211	Major facilitator Superfamily
C5I45_10760	COG0174	glutamine synthetase
C5I45_10765	COG0789	Transcriptional regulator
C5I45_10770	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C5I45_10775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5I45_10780	COG0464	growth
C5I45_10790	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5I45_10795	COG4112	unkown
C5I45_10800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5I45_10805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5I45_10845	COG2076	Multidrug Resistance protein
C5I45_10855	COG1764	response to oxidative stress
C5I45_10860	COG4195	phage-related replication protein
C5I45_10870	COG1404	Belongs to the peptidase S8 family
C5I45_10880	COG3619	membrane
C5I45_10885	COG3209	COG3209 Rhs family protein
C5I45_10890	COG2124	cytochrome p450
C5I45_10895	COG3321	synthase
C5I45_10895	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C5I45_10895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5I45_10895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_10900	COG4221	oxidoreductase activity
C5I45_10900	COG3321	synthase
C5I45_10900	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_10900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_10905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_10905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_10905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_10905	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_10905	COG3321	synthase
C5I45_10905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_10905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_10905	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_10905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_10905	COG3321	synthase
C5I45_10910	COG3321	synthase
C5I45_10910	COG0300	oxidoreductase activity
C5I45_10910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_10910	COG4221	oxidoreductase activity
C5I45_10915	COG0300	oxidoreductase activity
C5I45_10915	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_10915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_10915	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_10915	COG3321	synthase
C5I45_10920	COG1024	Enoyl-CoA hydratase
C5I45_10925	COG1024	Enoyl-CoA hydratase
C5I45_10930	COG3425	synthase
C5I45_10935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_10985	COG4550	Control of competence regulator ComK, YlbF/YmcA
C5I45_11005	COG2359	stage V sporulation protein S
C5I45_11010	COG1692	metallophosphoesterase
C5I45_11020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5I45_11035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5I45_11040	COG1426	Protein conserved in bacteria
C5I45_11055	COG0300	oxidoreductase activity
C5I45_11060	COG0612	Peptidase, M16
C5I45_11065	COG0612	Peptidase, M16
C5I45_11070	COG2409	Drug exporters of the RND superfamily
C5I45_11070	COG1033	growth of symbiont in host cell
C5I45_11075	COG1846	Transcriptional regulator
C5I45_11080	COG2814	Major facilitator Superfamily
C5I45_11085	COG2188	Transcriptional regulator
C5I45_11090	COG4980	gas vesicle protein
C5I45_11090	COG1674	ftsk spoiiie
C5I45_11100	COG0740	serine-type endopeptidase activity
C5I45_11105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C5I45_11115	COG0527	aspartate kinase activity
C5I45_11120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5I45_11125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5I45_11130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5I45_11135	COG1873	PFAM PRC-barrel domain
C5I45_11140	COG0612	Peptidase, M16
C5I45_11145	COG0726	polysaccharide deacetylase
C5I45_11160	COG0196	riboflavin kinase activity
C5I45_11175	COG1550	Protein conserved in bacteria
C5I45_11185	COG1358	cellular component organization or biogenesis
C5I45_11190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C5I45_11195	COG0195	Participates in both transcription termination and antitermination
C5I45_11205	COG2176	DNA-directed DNA polymerase activity
C5I45_11215	COG0750	zinc metalloprotease
C5I45_11225	COG4589	Belongs to the CDS family
C5I45_11230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5I45_11260	COG1191	sigma factor activity
C5I45_11270	COG1776	CheC inhibitor of MCP methylation
C5I45_11275	COG0835	chemotaxis
C5I45_11280	COG2198	Histidine kinase
C5I45_11280	COG0643	Histidine kinase
C5I45_11285	COG2201	protein-glutamate methylesterase activity
C5I45_11290	COG0455	bacterial-type flagellum organization
C5I45_11295	COG1419	protein localization to endoplasmic reticulum
C5I45_11300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5I45_11305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5I45_11310	COG1684	flagellar biosynthetic protein fliR
C5I45_11315	COG1987	bacterial-type flagellum assembly
C5I45_11320	COG1338	Plays a role in the flagellum-specific transport system
C5I45_11325	COG3190	flagellar
C5I45_11330	COG2201	protein-glutamate methylesterase activity
C5I45_11335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5I45_11335	COG1776	CheC inhibitor of MCP methylation
C5I45_11340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5I45_11345	COG1580	Controls the rotational direction of flagella during chemotaxis
C5I45_11350	COG1582	Flagellar protein (FlbD)
C5I45_11355	COG4786	Flagellar basal body rod
C5I45_11360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5I45_11365	COG3144	bacterial-type flagellum assembly
C5I45_11370	COG3334	PFAM MgtE intracellular
C5I45_11375	COG2882	bacterial-type flagellum organization
C5I45_11380	COG1157	protein secretion by the type III secretion system
C5I45_11385	COG1317	bacterial-type flagellum organization
C5I45_11390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5I45_11395	COG1766	The M ring may be actively involved in energy transduction
C5I45_11400	COG1677	Flagellar hook-basal body complex protein FliE
C5I45_11405	COG1558	bacterial-type flagellum-dependent cell motility
C5I45_11410	COG1815	bacterial-type flagellum-dependent cell motility
C5I45_11430	COG4974	Belongs to the 'phage' integrase family
C5I45_11440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5I45_11445	COG0758	DNA mediated transformation
C5I45_11450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5I45_11460	COG2257	FlhB HrpN YscU SpaS Family
C5I45_11475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C5I45_11500	COG1837	Belongs to the UPF0109 family
C5I45_11510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5I45_11525	COG0552	protein localization to endoplasmic reticulum
C5I45_11530	COG1196	nuclear chromosome segregation
C5I45_11540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_11545	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_11550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5I45_11565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5I45_11570	COG1760	l-serine dehydratase
C5I45_11575	COG1760	l-serine dehydratase
C5I45_11580	COG1461	Dihydroxyacetone kinase
C5I45_11585	COG1302	Protein conserved in bacteria
C5I45_11600	COG1564	THIamine pyrophosphokinase
C5I45_11605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5I45_11615	COG0515	serine threonine protein kinase
C5I45_11615	COG2815	serine threonine protein kinase
C5I45_11620	COG0631	protein serine/threonine phosphatase activity
C5I45_11630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5I45_11630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5I45_11640	COG0242	peptide deformylase activity
C5I45_11645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5I45_11650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5I45_11660	COG0194	GDP metabolic process
C5I45_11665	COG2052	Domain of unknown function (DUF370)
C5I45_11670	COG1561	YicC-like family, N-terminal region
C5I45_11675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5I45_11690	COG1648	precorrin-2 dehydrogenase activity
C5I45_11695	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C5I45_11700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5I45_11715	COG0306	phosphate transporter
C5I45_11725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5I45_11730	COG0284	orotidine-5'-phosphate decarboxylase activity
C5I45_11745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5I45_11750	COG0505	Belongs to the CarA family
C5I45_11755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5I45_11765	COG2233	PERMEase
C5I45_11775	COG0564	pseudouridine synthase activity
C5I45_11785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5I45_11790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5I45_11800	COG3599	regulation of cell shape
C5I45_11805	COG2302	S4 RNA-binding domain
C5I45_11810	COG0762	integral membrane protein
C5I45_11820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5I45_11830	COG1873	PFAM PRC-barrel domain
C5I45_11835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5I45_11840	COG1119	ATPase activity
C5I45_11845	COG1191	sigma factor activity
C5I45_11850	COG1191	sigma factor activity
C5I45_11860	COG4412	M6 family metalloprotease domain protein
C5I45_11860	COG1404	Belongs to the peptidase S8 family
C5I45_11865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5I45_11870	COG0849	cell division
C5I45_11875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5I45_11890	COG0772	Belongs to the SEDS family
C5I45_11910	COG0768	penicillin binding
C5I45_11920	COG4839	cell division protein FtsL
C5I45_11940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5I45_11955	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5I45_11960	COG1399	metal-binding, possibly nucleic acid-binding protein
C5I45_11970	COG3480	Lon protease (S16) C-terminal proteolytic domain
C5I45_11975	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5I45_11980	COG3314	Sporulation integral membrane protein YlbJ
C5I45_11990	COG0742	ribosomal rna small subunit methyltransferase
C5I45_12005	COG3679	Belongs to the UPF0342 family
C5I45_12020	COG2340	Cysteine-rich secretory protein family
C5I45_12025	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C5I45_12035	COG3336	cytochrome c oxidase
C5I45_12040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C5I45_12045	COG1845	cytochrome c oxidase, subunit III
C5I45_12050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5I45_12055	COG2010	Cytochrome c
C5I45_12055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5I45_12070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C5I45_12075	COG0772	Belongs to the SEDS family
C5I45_12085	COG2066	Belongs to the glutaminase family
C5I45_12090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5I45_12095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5I45_12105	COG4896	Protein conserved in bacteria
C5I45_12140	COG3227	Zinc metalloprotease (Elastase)
C5I45_12150	COG0483	inositol monophosphate 1-phosphatase activity
C5I45_12180	COG1982	Orn Lys Arg decarboxylase major
C5I45_12195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_12200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5I45_12205	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5I45_12210	COG0022	dehydrogenase e1 component
C5I45_12215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5I45_12220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5I45_12225	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_12225	COG4221	oxidoreductase activity
C5I45_12225	COG3321	synthase
C5I45_12225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_12230	COG4221	oxidoreductase activity
C5I45_12230	COG3321	synthase
C5I45_12230	COG0300	oxidoreductase activity
C5I45_12230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_12235	COG4221	oxidoreductase activity
C5I45_12235	COG3321	synthase
C5I45_12235	COG0300	oxidoreductase activity
C5I45_12235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_12240	COG3321	synthase
C5I45_12240	COG0300	oxidoreductase activity
C5I45_12240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_12240	COG4221	oxidoreductase activity
C5I45_12245	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_12245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_12245	COG3321	synthase
C5I45_12245	COG4221	oxidoreductase activity
C5I45_12250	COG0300	oxidoreductase activity
C5I45_12250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_12250	COG4221	oxidoreductase activity
C5I45_12250	COG3321	synthase
C5I45_12255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_12255	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_12255	COG3321	synthase
C5I45_12255	COG4221	oxidoreductase activity
C5I45_12270	COG0497	DNA recombination
C5I45_12280	COG0242	peptide deformylase activity
C5I45_12285	COG0561	phosphatase activity
C5I45_12300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C5I45_12310	COG0569	domain protein
C5I45_12315	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C5I45_12315	COG2105	PFAM AIG2 family protein
C5I45_12320	COG3852	Histidine kinase
C5I45_12325	COG2002	toxin-antitoxin pair type II binding
C5I45_12335	COG1077	Cell shape determining protein MreB Mrl
C5I45_12345	COG2309	aminopeptidase activity
C5I45_12350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5I45_12355	COG0488	(ABC) transporter
C5I45_12365	COG0681	Belongs to the peptidase S26 family
C5I45_12370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5I45_12370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5I45_12370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5I45_12375	COG1105	Belongs to the carbohydrate kinase PfkB family
C5I45_12380	COG1349	DNA-binding transcription factor activity
C5I45_12385	COG0577	efflux transmembrane transporter activity
C5I45_12390	COG1136	(ABC) transporter
C5I45_12395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5I45_12405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C5I45_12410	COG0314	molybdopterin synthase activity
C5I45_12415	COG1763	Mo-molybdopterin cofactor biosynthetic process
C5I45_12420	COG0303	'Molybdopterin
C5I45_12425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5I45_12445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_12450	COG0668	transmembrane transport
C5I45_12470	COG0716	FMN binding
C5I45_12480	COG0716	FMN binding
C5I45_12485	COG0583	DNA-binding transcription factor activity
C5I45_12490	COG0517	IMP dehydrogenase activity
C5I45_12500	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C5I45_12505	COG4703	Protein of unknown function (DUF1797)
C5I45_12510	COG2200	EAL domain
C5I45_12525	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_12530	COG1408	metallophosphoesterase
C5I45_12535	COG1376	ErfK ybiS ycfS ynhG family protein
C5I45_12540	COG2814	Major facilitator Superfamily
C5I45_12550	COG0784	Response regulator, receiver
C5I45_12550	COG0835	chemotaxis
C5I45_12560	COG0436	Aminotransferase
C5I45_12565	COG4191	Histidine kinase
C5I45_12570	COG0768	penicillin binding
C5I45_12575	COG2340	Cysteine-rich secretory protein family
C5I45_12580	COG2084	Dehydrogenase
C5I45_12585	COG0840	transmembrane signaling receptor activity
C5I45_12590	COG1533	DNA photolyase activity
C5I45_12600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5I45_12605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5I45_12610	COG1263	PTS System
C5I45_12610	COG2190	(PTS) system
C5I45_12610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5I45_12615	COG3711	transcriptional antiterminator
C5I45_12620	COG1609	Transcriptional regulator
C5I45_12625	COG0006	proline dipeptidase activity
C5I45_12630	COG2217	Heavy metal translocating P-type atpase
C5I45_12635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_12640	COG2244	polysaccharide biosynthetic process
C5I45_12645	COG3773	Cell wall hydrolase
C5I45_12655	COG4873	Protein conserved in bacteria
C5I45_12670	COG0602	queuosine metabolic process
C5I45_12675	COG0720	synthase
C5I45_12690	COG3949	Membrane
C5I45_12700	COG0542	response to heat
C5I45_12705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C5I45_12710	COG1360	Flagellar Motor Protein
C5I45_12715	COG1846	Transcriptional regulator
C5I45_12720	COG3852	Histidine kinase
C5I45_12750	COG0436	Aminotransferase
C5I45_12755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5I45_12770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5I45_12775	COG5002	protein histidine kinase activity
C5I45_12780	COG3594	Acyltransferase
C5I45_12790	COG2323	membrane
C5I45_12795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5I45_12820	COG1191	sigma factor activity
C5I45_12825	COG0861	Integral membrane protein TerC family
C5I45_12830	COG0586	Pfam SNARE associated Golgi protein
C5I45_12840	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C5I45_12845	COG1793	dna ligase
C5I45_12845	COG3285	dna ligase
C5I45_12850	COG0726	polysaccharide deacetylase
C5I45_12855	COG1846	Transcriptional regulator
C5I45_12870	COG0789	Transcriptional regulator
C5I45_12875	COG2239	Acts as a magnesium transporter
C5I45_12890	COG1388	LysM domain
C5I45_12890	COG3858	chitin binding
C5I45_12895	COG4721	ABC-type cobalt transport system, permease component
C5I45_12900	COG1122	ATPase activity
C5I45_12905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5I45_12910	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_12915	COG1404	Belongs to the peptidase S8 family
C5I45_12925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5I45_12930	COG2814	Major facilitator Superfamily
C5I45_12940	COG0463	Glycosyl transferase, family 2
C5I45_12940	COG0457	Tetratricopeptide repeat
C5I45_12955	COG1764	response to oxidative stress
C5I45_12960	COG1846	Transcriptional regulator
C5I45_12965	COG1764	response to oxidative stress
C5I45_12975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5I45_12980	COG0788	formyltetrahydrofolate deformylase activity
C5I45_12985	COG2076	Multidrug Resistance protein
C5I45_12990	COG2076	Multidrug Resistance protein
C5I45_12995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5I45_13000	COG1607	acyl-coa hydrolase
C5I45_13005	COG1834	amidinotransferase
C5I45_13010	COG2706	6-phosphogluconolactonase activity
C5I45_13015	COG4608	Belongs to the ABC transporter superfamily
C5I45_13020	COG0791	NLP P60 protein
C5I45_13025	COG4948	Mandelate Racemase Muconate Lactonizing
C5I45_13030	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5I45_13035	COG4166	transmembrane transport
C5I45_13040	COG0444	Belongs to the ABC transporter superfamily
C5I45_13045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5I45_13050	COG0601	transmembrane transport
C5I45_13055	COG2362	D-Aminopeptidase
C5I45_13060	COG0477	Major facilitator Superfamily
C5I45_13065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5I45_13070	COG0463	Glycosyl transferase, family 2
C5I45_13075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5I45_13080	COG0346	lactoylglutathione lyase activity
C5I45_13085	COG0531	amino acid
C5I45_13090	COG1392	Phosphate transport regulator
C5I45_13095	COG0306	phosphate transporter
C5I45_13110	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5I45_13110	COG3409	Peptidoglycan-binding domain 1 protein
C5I45_13150	COG3778	Protein conserved in bacteria
C5I45_13155	COG3299	homolog of phage Mu protein gp47
C5I45_13160	COG3628	GPW Gp25 family protein
C5I45_13170	COG4193	domain, Protein
C5I45_13175	COG1652	LysM domain
C5I45_13180	COG5412	phage tail tape measure protein
C5I45_13180	COG3953	SLT domain
C5I45_13180	COG3953	SLT domain
C5I45_13180	COG3953	SLT domain
C5I45_13180	COG5412	phage tail tape measure protein
C5I45_13180	COG5412	phage tail tape measure protein
C5I45_13230	COG4653	Phage capsid family
C5I45_13235	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C5I45_13240	COG5518	Phage portal protein
C5I45_13245	COG1783	phage Terminase large subunit
C5I45_13250	COG3728	DNA packaging
C5I45_13250	COG5484	DNA packaging
C5I45_13255	COG1595	DNA-templated transcription, initiation
C5I45_13270	COG1484	DNA-dependent DNA replication
C5I45_13275	COG1522	sequence-specific DNA binding
C5I45_13285	COG1396	sequence-specific DNA binding
C5I45_13290	COG2856	Zn peptidase
C5I45_13295	COG4195	phage-related replication protein
C5I45_13305	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5I45_13305	COG3409	Peptidoglycan-binding domain 1 protein
C5I45_13305	COG1388	LysM domain
C5I45_13310	COG0457	Tetratricopeptide repeat
C5I45_13315	COG2318	DinB family
C5I45_13320	COG0730	response to heat
C5I45_13335	COG2770	Histidine kinase
C5I45_13335	COG2205	protein histidine kinase activity
C5I45_13340	COG0745	RESPONSE REGULATOR receiver
C5I45_13345	COG2721	sulfolactate sulfo-lyase activity
C5I45_13350	COG0246	Mannitol dehydrogenase
C5I45_13355	COG1609	Transcriptional regulator
C5I45_13360	COG2211	Major facilitator Superfamily
C5I45_13370	COG1252	NADH dehydrogenase
C5I45_13380	COG4297	protein containing double-stranded beta helix domain
C5I45_13385	COG0697	spore germination
C5I45_13390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5I45_13395	COG0390	transport system, permease component
C5I45_13400	COG1587	Uroporphyrinogen-III synthase
C5I45_13410	COG1819	glycosyl
C5I45_13415	COG2124	cytochrome p450
C5I45_13420	COG2427	Protein of unknown function (DUF1641)
C5I45_13425	COG3383	formate dehydrogenase (NAD+) activity
C5I45_13435	COG2205	protein histidine kinase activity
C5I45_13450	COG1285	pathogenesis
C5I45_13470	COG1349	DNA-binding transcription factor activity
C5I45_13480	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5I45_13485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5I45_13485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5I45_13490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5I45_13495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5I45_13500	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C5I45_13510	COG1846	Transcriptional regulator
C5I45_13520	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5I45_13525	COG2367	Beta-lactamase
C5I45_13530	COG0346	lactoylglutathione lyase activity
C5I45_13585	COG0626	cystathionine gamma-synthase activity
C5I45_13590	COG0626	cystathionine gamma-synthase activity
C5I45_13595	COG2382	esterase
C5I45_13605	COG2153	protein acetylation
C5I45_13615	COG1131	(ABC) transporter
C5I45_13635	COG0210	DNA helicase
C5I45_13690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5I45_13695	COG0351	phosphomethylpyrimidine kinase
C5I45_13700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5I45_13710	COG2104	thiamine diphosphate biosynthetic process
C5I45_13715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5I45_13720	COG0352	thiamine-phosphate diphosphorylase activity
C5I45_13725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C5I45_13730	COG0475	glutathione-regulated potassium exporter activity
C5I45_13730	COG0569	domain protein
C5I45_13745	COG0564	pseudouridine synthase activity
C5I45_13750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5I45_13755	COG2357	RelA SpoT domain protein
C5I45_13765	COG4116	CYTH
C5I45_13770	COG0741	lytic transglycosylase activity
C5I45_13775	COG2346	COG2346, Truncated hemoglobins
C5I45_13785	COG1164	Oligoendopeptidase f
C5I45_13790	COG4469	Competence protein
C5I45_13795	COG4862	establishment of competence for transformation
C5I45_13800	COG0861	Integral membrane protein TerC family
C5I45_13805	COG1393	Belongs to the ArsC family
C5I45_13810	COG0456	acetyltransferase
C5I45_13820	COG4608	Belongs to the ABC transporter superfamily
C5I45_13825	COG0444	Belongs to the ABC transporter superfamily
C5I45_13830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5I45_13835	COG0601	transmembrane transport
C5I45_13840	COG4166	transmembrane transport
C5I45_13845	COG0180	Tryptophanyl-tRNA synthetase
C5I45_13855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5I45_13860	COG0601	transmembrane transport
C5I45_13870	COG4608	Belongs to the ABC transporter superfamily
C5I45_13875	COG0444	Belongs to the ABC transporter superfamily
C5I45_13880	COG5504	Zn-dependent protease
C5I45_13885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5I45_13890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5I45_13905	COG1744	ABC transporter substrate-binding protein PnrA-like
C5I45_13915	COG2267	carboxylic ester hydrolase activity
C5I45_13935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5I45_13940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5I45_13945	COG0505	Belongs to the CarA family
C5I45_13950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5I45_13970	COG2271	Major facilitator Superfamily
C5I45_13975	COG0277	FAD linked oxidase domain protein
C5I45_13985	COG2151	metal-sulfur cluster biosynthetic enzyme
C5I45_13990	COG1073	alpha beta
C5I45_13995	COG0561	phosphatase activity
C5I45_14010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5I45_14015	COG1307	EDD domain protein, DegV family
C5I45_14025	COG0840	transmembrane signaling receptor activity
C5I45_14035	COG2996	Protein conserved in bacteria
C5I45_14045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5I45_14045	COG0646	methionine synthase
C5I45_14050	COG2153	protein acetylation
C5I45_14055	COG1357	PFAM Pentapeptide repeats (8 copies)
C5I45_14065	COG2318	DinB family
C5I45_14070	COG0673	inositol 2-dehydrogenase activity
C5I45_14075	COG1609	Transcriptional regulator
C5I45_14080	COG2207	Transcriptional regulator
C5I45_14080	COG1917	Cupin 2, conserved barrel domain protein
C5I45_14085	COG0534	Mate efflux family protein
C5I45_14090	COG1562	ergosterol biosynthetic process
C5I45_14095	COG0367	asparagine synthase
C5I45_14115	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5I45_14155	COG1403	HNH endonuclease
C5I45_14160	COG0419	ATPase involved in DNA repair
C5I45_14165	COG0420	3'-5' exonuclease activity
C5I45_14180	COG2323	membrane
C5I45_14185	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C5I45_14195	COG2814	Major facilitator Superfamily
C5I45_14200	COG3180	Ammonia monooxygenase
C5I45_14205	COG1846	Transcriptional regulator
C5I45_14210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5I45_14215	COG0681	Belongs to the peptidase S26 family
C5I45_14220	COG0398	Pfam SNARE associated Golgi protein
C5I45_14235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5I45_14255	COG5646	InterPro IPR014922
C5I45_14275	COG4903	ComK protein
C5I45_14285	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_14290	COG0723	plastoquinol--plastocyanin reductase activity
C5I45_14290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5I45_14295	COG0840	transmembrane signaling receptor activity
C5I45_14300	COG1268	BioY protein
C5I45_14305	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_14310	COG0183	Belongs to the thiolase family
C5I45_14315	COG0406	alpha-ribazole phosphatase activity
C5I45_14320	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C5I45_14330	COG1404	Belongs to the peptidase S8 family
C5I45_14335	COG0501	Belongs to the peptidase M48B family
C5I45_14345	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_14350	COG0702	epimerase
C5I45_14355	COG0095	Lipoate-protein ligase
C5I45_14360	COG1234	tRNA 3'-trailer cleavage
C5I45_14370	COG1301	dicarboxylic acid transport
C5I45_14375	COG1363	Peptidase, m42
C5I45_14385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5I45_14390	COG1511	domain protein
C5I45_14395	COG1309	transcriptional regulator
C5I45_14415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5I45_14420	COG2329	Antibiotic biosynthesis monooxygenase
C5I45_14425	COG3069	C4-dicarboxylate transmembrane transporter activity
C5I45_14430	COG1473	amidohydrolase
C5I45_14440	COG4473	ABC transporter
C5I45_14445	COG1131	(ABC) transporter
C5I45_14450	COG0537	adenosine 5'-monophosphoramidase activity
C5I45_14455	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5I45_14470	COG4980	gas vesicle protein
C5I45_14510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5I45_14525	COG4717	serine-type aminopeptidase activity
C5I45_14530	COG0420	3'-5' exonuclease activity
C5I45_14535	COG1668	transmembrane transport
C5I45_14540	COG4152	abc transporter atp-binding protein
C5I45_14550	COG1024	Enoyl-CoA hydratase
C5I45_14560	COG0490	domain, Protein
C5I45_14565	COG0475	glutathione-regulated potassium exporter activity
C5I45_14575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5I45_14580	COG0561	phosphatase activity
C5I45_14585	COG4335	DNA alkylation repair
C5I45_14600	COG0189	ligase activity
C5I45_14605	COG0189	ligase activity
C5I45_14625	COG0702	epimerase
C5I45_14630	COG1132	(ABC) transporter
C5I45_14635	COG1132	(ABC) transporter
C5I45_14640	COG0589	response to stress
C5I45_14650	COG3226	Transcriptional regulator
C5I45_14655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5I45_14660	COG0726	polysaccharide deacetylase
C5I45_14665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5I45_14670	COG0668	transmembrane transport
C5I45_14680	COG0584	glycerophosphoryl diester phosphodiesterase
C5I45_14685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5I45_14690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5I45_14695	COG1253	flavin adenine dinucleotide binding
C5I45_14700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5I45_14705	COG0436	Aminotransferase
C5I45_14710	COG0789	Transcriptional regulator
C5I45_14715	COG1253	flavin adenine dinucleotide binding
C5I45_14720	COG0204	Acyl-transferase
C5I45_14725	COG1595	DNA-templated transcription, initiation
C5I45_14740	COG0733	neurotransmitter:sodium symporter activity
C5I45_14745	COG0531	amino acid
C5I45_14750	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_14755	COG0372	Belongs to the citrate synthase family
C5I45_14760	COG0583	DNA-binding transcription factor activity
C5I45_14765	COG1388	LysM domain
C5I45_14765	COG0791	NLP P60 protein
C5I45_14770	COG1785	Belongs to the alkaline phosphatase family
C5I45_14775	COG2719	SpoVR family
C5I45_14780	COG0668	transmembrane transport
C5I45_14785	COG1959	2 iron, 2 sulfur cluster binding
C5I45_14790	COG1388	LysM domain
C5I45_14790	COG0791	NLP P60 protein
C5I45_14805	COG0431	NADPH-dependent FMN reductase
C5I45_14810	COG2197	response regulator
C5I45_14815	COG2203	Gaf domain
C5I45_14815	COG4585	Histidine kinase
C5I45_14820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5I45_14825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5I45_14835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5I45_14840	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C5I45_14845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5I45_14850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5I45_14850	COG3153	acetyltransferase
C5I45_14855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5I45_14860	COG0517	IMP dehydrogenase activity
C5I45_14870	COG0564	pseudouridine synthase activity
C5I45_14875	COG3764	Sortase (surface protein transpeptidase)
C5I45_14880	COG4085	toxin activity
C5I45_14880	COG0737	Belongs to the 5'-nucleotidase family
C5I45_14880	COG1525	nuclease
C5I45_14885	COG5577	PFAM Coat F domain
C5I45_14905	COG1823	symporter activity
C5I45_14910	COG3706	GGDEF domain
C5I45_14915	COG1464	Belongs to the NlpA lipoprotein family
C5I45_14925	COG1278	Cold shock
C5I45_14930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C5I45_14935	COG1131	(ABC) transporter
C5I45_14940	COG1131	(ABC) transporter
C5I45_14945	COG1725	Transcriptional regulator
C5I45_14960	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5I45_14965	COG2814	Major facilitator Superfamily
C5I45_14970	COG1566	PFAM secretion protein HlyD family protein
C5I45_14975	COG1846	Transcriptional regulator
C5I45_14990	COG2766	serine protein kinase
C5I45_14995	COG1664	Polymer-forming cytoskeletal
C5I45_15000	COG1664	Polymer-forming cytoskeletal
C5I45_15005	COG0789	Transcriptional regulator
C5I45_15010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5I45_15020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5I45_15025	COG3382	B3 4 domain protein
C5I45_15035	COG1476	TRANSCRIPTIONal
C5I45_15055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5I45_15060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5I45_15065	COG1116	anion transmembrane transporter activity
C5I45_15080	COG0753	catalase activity
C5I45_15085	COG4608	Belongs to the ABC transporter superfamily
C5I45_15090	COG0444	Belongs to the ABC transporter superfamily
C5I45_15095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5I45_15100	COG0601	transmembrane transport
C5I45_15105	COG0747	negative chemotaxis
C5I45_15115	COG0277	FAD linked oxidase domain protein
C5I45_15125	COG3340	Belongs to the peptidase S51 family
C5I45_15240	COG0735	belongs to the Fur family
C5I45_15245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5I45_15255	COG4129	membrane
C5I45_15260	COG1132	(ABC) transporter
C5I45_15280	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_15290	COG1194	a g-specific adenine glycosylase
C5I45_15295	COG1988	membrane-bound metal-dependent
C5I45_15300	COG4485	Bacterial membrane protein, YfhO
C5I45_15305	COG0463	Glycosyl transferase, family 2
C5I45_15310	COG0596	Alpha beta hydrolase
C5I45_15315	COG5658	integral membrane protein
C5I45_15320	COG3103	Sh3 type 3 domain protein
C5I45_15335	COG3591	Belongs to the peptidase S1B family
C5I45_15345	COG2814	Major facilitator Superfamily
C5I45_15360	COG1090	epimerase
C5I45_15375	COG0778	Nitroreductase
C5I45_15380	COG0384	phenazine biosynthesis protein PhzF
C5I45_15385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5I45_15385	COG0392	lysyltransferase activity
C5I45_15390	COG1846	Transcriptional regulator
C5I45_15395	COG2814	Major facilitator Superfamily
C5I45_15400	COG2318	DinB family
C5I45_15405	COG2732	(Barnase) inhibitor
C5I45_15410	COG3848	Pyruvate phosphate dikinase
C5I45_15410	COG0574	Belongs to the PEP-utilizing enzyme family
C5I45_15415	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C5I45_15420	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5I45_15425	COG1695	Transcriptional regulator
C5I45_15440	COG2514	catechol 2,3-dioxygenase activity
C5I45_15445	COG2259	Doxx family
C5I45_15450	COG1132	(ABC) transporter
C5I45_15455	COG1132	(ABC) transporter
C5I45_15460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5I45_15460	COG1263	PTS System
C5I45_15465	COG1737	Transcriptional regulator
C5I45_15470	COG1486	melibiose metabolic process
C5I45_15480	COG3284	Transcriptional regulator
C5I45_15485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5I45_15490	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5I45_15495	COG0022	dehydrogenase e1 component
C5I45_15500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5I45_15505	COG4637	Psort location Cytoplasmic, score
C5I45_15510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5I45_15520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5I45_15525	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C5I45_15530	COG0598	Magnesium transport protein CorA
C5I45_15540	COG2084	Dehydrogenase
C5I45_15545	COG0726	polysaccharide deacetylase
C5I45_15555	COG0535	radical SAM domain protein
C5I45_15560	COG0668	transmembrane transport
C5I45_15570	COG0387	Pfam Sodium calcium exchanger
C5I45_15575	COG0477	Major facilitator Superfamily
C5I45_15580	COG1295	ribonuclease BN
C5I45_15585	COG4980	gas vesicle protein
C5I45_15590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5I45_15600	COG2814	Major facilitator Superfamily
C5I45_15610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5I45_15615	COG1609	Transcriptional regulator
C5I45_15620	COG0693	protein deglycase activity
C5I45_15625	COG0737	Belongs to the 5'-nucleotidase family
C5I45_15640	COG0778	Nitroreductase
C5I45_15645	COG2188	Transcriptional regulator
C5I45_15650	COG0366	Alpha amylase catalytic
C5I45_15655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5I45_15655	COG1263	PTS System
C5I45_15670	COG0071	Belongs to the small heat shock protein (HSP20) family
C5I45_15680	COG1368	sulfuric ester hydrolase activity
C5I45_15690	COG1263	PTS System
C5I45_15690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5I45_15695	COG0024	Methionine aminopeptidase
C5I45_15715	COG2258	MOSC domain
C5I45_15725	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C5I45_15730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5I45_15735	COG2851	Citrate transporter
C5I45_15740	COG3181	Tripartite tricarboxylate transporter family receptor
C5I45_15745	COG4565	transcriptional regulatory protein
C5I45_15750	COG3290	protein histidine kinase activity
C5I45_15765	COG0471	metal ion transport
C5I45_15770	COG3866	Pectate lyase
C5I45_15785	COG2130	NADP-dependent
C5I45_15795	COG0513	Belongs to the DEAD box helicase family
C5I45_15800	COG0488	(ABC) transporter
C5I45_15805	COG2814	Major facilitator Superfamily
C5I45_15810	COG0789	Transcriptional regulator
C5I45_15815	COG0488	(ABC) transporter
C5I45_15820	COG0463	Glycosyl transferase, family 2
C5I45_15820	COG0457	Tetratricopeptide repeat
C5I45_15825	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_15830	COG0840	transmembrane signaling receptor activity
C5I45_15835	COG1012	belongs to the aldehyde dehydrogenase family
C5I45_15840	COG0531	amino acid
C5I45_15845	COG2223	nitrite transmembrane transporter activity
C5I45_15850	COG1442	glycosyl transferase family 8
C5I45_15855	COG1216	Glycosyl transferase, family 2
C5I45_15860	COG1442	glycosyl transferase family 8
C5I45_15865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5I45_15870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5I45_15875	COG1368	sulfuric ester hydrolase activity
C5I45_15885	COG1131	(ABC) transporter
C5I45_15900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5I45_15900	COG2124	cytochrome p450
C5I45_15910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5I45_15915	COG1846	Transcriptional regulator
C5I45_15920	COG0670	Belongs to the BI1 family
C5I45_15925	COG0196	riboflavin kinase activity
C5I45_15930	COG5583	Uncharacterized small protein (DUF2292)
C5I45_15935	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_15940	COG0346	lactoylglutathione lyase activity
C5I45_15945	COG2329	Antibiotic biosynthesis monooxygenase
C5I45_15950	COG2323	membrane
C5I45_15960	COG0454	-acetyltransferase
C5I45_15965	COG3546	catalase activity
C5I45_16020	COG1131	(ABC) transporter
C5I45_16025	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_16035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5I45_16045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5I45_16055	COG2197	response regulator
C5I45_16060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5I45_16065	COG1597	lipid kinase activity
C5I45_16070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5I45_16075	COG1309	transcriptional regulator
C5I45_16095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5I45_16100	COG1285	pathogenesis
C5I45_16105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5I45_16110	COG4851	CamS sex pheromone cAM373 precursor
C5I45_16120	COG0210	DNA helicase
C5I45_16135	COG0069	glutamate synthase activity
C5I45_16140	COG4496	protein, YerC YecD
C5I45_16145	COG1470	cell adhesion involved in biofilm formation
C5I45_16150	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5I45_16160	COG0151	Belongs to the GarS family
C5I45_16165	COG0138	bifunctional purine biosynthesis protein purh
C5I45_16170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5I45_16180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5I45_16195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5I45_16200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5I45_16205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5I45_16210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5I45_16215	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5I45_16235	COG3064	Membrane
C5I45_16240	COG2252	PERMEase
C5I45_16260	COG1305	Transglutaminase-like
C5I45_16265	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C5I45_16270	COG0714	Associated with various cellular activities
C5I45_16275	COG1113	amino acid transport
C5I45_16280	COG2132	Multicopper oxidase
C5I45_16290	COG0823	Involved in the tonB-independent uptake of proteins
C5I45_16295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5I45_16300	COG1063	alcohol dehydrogenase
C5I45_16305	COG1595	DNA-templated transcription, initiation
C5I45_16315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5I45_16315	COG2755	lipolytic protein G-D-S-L family
C5I45_16320	COG4260	virion core protein, lumpy skin disease virus
C5I45_16325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5I45_16330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5I45_16335	COG1842	Phage shock protein A
C5I45_16345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5I45_16350	COG2211	Major facilitator Superfamily
C5I45_16355	COG1063	alcohol dehydrogenase
C5I45_16360	COG0457	Tetratricopeptide repeat
C5I45_16385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5I45_16390	COG1266	CAAX protease self-immunity
C5I45_16400	COG0805	protein transport
C5I45_16405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5I45_16420	COG0488	(ABC) transporter
C5I45_16425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5I45_16430	COG0456	acetyltransferase
C5I45_16435	COG1214	PFAM Peptidase M22, glycoprotease
C5I45_16440	COG0802	atpase or kinase
C5I45_16445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5I45_16485	COG2814	Major facilitator Superfamily
C5I45_16490	COG0604	alcohol dehydrogenase
C5I45_16495	COG3832	glyoxalase III activity
C5I45_16505	COG0531	amino acid
C5I45_16510	COG1309	transcriptional regulator
C5I45_16515	COG2076	Multidrug Resistance protein
C5I45_16520	COG2076	Multidrug Resistance protein
C5I45_16525	COG2807	transmembrane transport
C5I45_16530	COG2186	Transcriptional regulator
C5I45_16535	COG2188	Transcriptional regulator
C5I45_16540	COG2814	Major facilitator Superfamily
C5I45_16545	COG1388	LysM domain
C5I45_16550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5I45_16565	COG1819	glycosyl
C5I45_16570	COG1802	Transcriptional regulator
C5I45_16575	COG0473	3-isopropylmalate dehydrogenase activity
C5I45_16580	COG2226	methyltransferase
C5I45_16585	COG1051	belongs to the nudix hydrolase family
C5I45_16590	COG0697	spore germination
C5I45_16595	COG4978	Transcriptional regulator
C5I45_16595	COG0789	Transcriptional regulator
C5I45_16600	COG0456	acetyltransferase
C5I45_16605	COG0730	response to heat
C5I45_16615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5I45_16620	COG2814	Major facilitator Superfamily
C5I45_16630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5I45_16635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5I45_16645	COG1959	2 iron, 2 sulfur cluster binding
C5I45_16650	COG0477	Major facilitator Superfamily
C5I45_16655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C5I45_16660	COG2409	Drug exporters of the RND superfamily
C5I45_16665	COG2197	response regulator
C5I45_16670	COG4585	Histidine kinase
C5I45_16680	COG5577	PFAM Coat F domain
C5I45_16685	COG1063	alcohol dehydrogenase
C5I45_16695	COG5577	PFAM Coat F domain
C5I45_16705	COG1309	transcriptional regulator
C5I45_16710	COG2814	Major facilitator Superfamily
C5I45_16725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5I45_16735	COG0789	Transcriptional regulator
C5I45_16740	COG1064	alcohol dehydrogenase
C5I45_16765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5I45_16800	COG0277	FAD linked oxidase domain protein
C5I45_16820	COG0477	Major facilitator Superfamily
C5I45_16825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5I45_16835	COG2207	Transcriptional regulator
C5I45_16835	COG1917	Cupin 2, conserved barrel domain protein
C5I45_16840	COG1473	amidohydrolase
C5I45_16845	COG0814	amino acid
C5I45_16850	COG0251	oxidation-reduction process
C5I45_16855	COG1802	Transcriptional regulator
C5I45_16860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5I45_16870	COG3621	Patatin-like phospholipase
C5I45_16885	COG1794	racemase activity, acting on amino acids and derivatives
C5I45_16890	COG0730	response to heat
C5I45_16895	COG0425	Belongs to the sulfur carrier protein TusA family
C5I45_16900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5I45_16900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5I45_16905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5I45_16905	COG0425	Belongs to the sulfur carrier protein TusA family
C5I45_16915	COG2210	Belongs to the sulfur carrier protein TusA family
C5I45_16920	COG1937	Protein conserved in bacteria
C5I45_16930	COG1278	Cold shock
C5I45_16935	COG2910	NAD(P)H-binding
C5I45_16940	COG1959	2 iron, 2 sulfur cluster binding
C5I45_16945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5I45_16955	COG2030	dehydratase
C5I45_16965	COG1846	Transcriptional regulator
C5I45_16970	COG1764	response to oxidative stress
C5I45_16980	COG0477	Major facilitator Superfamily
C5I45_16985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5I45_17005	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5I45_17055	COG2183	response to ionizing radiation
C5I45_17060	COG2208	phosphoserine phosphatase activity
C5I45_17065	COG1191	sigma factor activity
C5I45_17075	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_17080	COG2208	phosphoserine phosphatase activity
C5I45_17085	COG2172	sigma factor antagonist activity
C5I45_17090	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_17095	COG1366	Belongs to the anti-sigma-factor antagonist family
C5I45_17100	COG2337	Toxic component of a toxin-antitoxin (TA) module
C5I45_17105	COG0864	Transcriptional regulator
C5I45_17110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5I45_17115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5I45_17125	COG0705	Rhomboid family
C5I45_17130	COG3428	Bacterial PH domain
C5I45_17135	COG3402	PFAM membrane-flanked domain
C5I45_17140	COG0513	Belongs to the DEAD box helicase family
C5I45_17145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5I45_17155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_17160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5I45_17175	COG1960	acyl-CoA dehydrogenase activity
C5I45_17185	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C5I45_17190	COG1131	(ABC) transporter
C5I45_17195	COG0628	permease
C5I45_17200	COG1301	dicarboxylic acid transport
C5I45_17205	COG4565	transcriptional regulatory protein
C5I45_17210	COG3290	protein histidine kinase activity
C5I45_17215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5I45_17220	COG3546	catalase activity
C5I45_17225	COG2329	Antibiotic biosynthesis monooxygenase
C5I45_17230	COG0662	Cupin 2, conserved barrel domain protein
C5I45_17235	COG3729	General stress protein
C5I45_17240	COG2217	Heavy metal translocating P-type atpase
C5I45_17245	COG2076	Multidrug Resistance protein
C5I45_17255	COG4876	unkown
C5I45_17270	COG1914	H( )-stimulated, divalent metal cation uptake system
C5I45_17345	COG0028	Belongs to the TPP enzyme family
C5I45_17350	COG0494	nUDIX hydrolase
C5I45_17355	COG0531	amino acid
C5I45_17365	COG1215	transferase activity, transferring glycosyl groups
C5I45_17370	COG5298	Protein conserved in bacteria
C5I45_17375	COG3706	GGDEF domain
C5I45_17380	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C5I45_17385	COG0551	DNA topoisomerase type I activity
C5I45_17385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5I45_17390	COG1522	sequence-specific DNA binding
C5I45_17395	COG2814	Major facilitator Superfamily
C5I45_17405	COG3871	stress protein (general stress protein 26)
C5I45_17410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5I45_17415	COG1917	Cupin 2, conserved barrel domain protein
C5I45_17420	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_17425	COG0318	PFAM AMP-dependent synthetase and ligase
C5I45_17430	COG3711	transcriptional antiterminator
C5I45_17435	COG4989	oxidoreductase activity
C5I45_17440	COG0768	penicillin binding
C5I45_17445	COG2329	Antibiotic biosynthesis monooxygenase
C5I45_17455	COG2755	lipolytic protein G-D-S-L family
C5I45_17460	COG1414	Transcriptional regulator
C5I45_17465	COG1984	allophanate hydrolase subunit 2
C5I45_17470	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5I45_17480	COG1914	H( )-stimulated, divalent metal cation uptake system
C5I45_17490	COG0561	phosphatase activity
C5I45_17500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5I45_17510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5I45_17515	COG2213	PTS system mannitol-specific
C5I45_17525	COG1349	DNA-binding transcription factor activity
C5I45_17530	COG2372	response to copper ion
C5I45_17530	COG1276	copper resistance
C5I45_17535	COG4549	nuclear export factor GLE1
C5I45_17540	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_17545	COG4975	Glucose uptake
C5I45_17550	COG1012	belongs to the aldehyde dehydrogenase family
C5I45_17555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5I45_17560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5I45_17565	COG0640	Transcriptional regulator
C5I45_17570	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5I45_17575	COG0778	Nitroreductase
C5I45_17580	COG1309	transcriptional regulator
C5I45_17585	COG2814	Major facilitator Superfamily
C5I45_17590	COG4607	ABC-type enterochelin transport system periplasmic component
C5I45_17595	COG4604	ABC transporter, ATP-binding protein
C5I45_17600	COG4605	iron ion homeostasis
C5I45_17605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_17615	COG0527	aspartate kinase activity
C5I45_17630	COG0457	Tetratricopeptide repeat
C5I45_17635	COG5002	protein histidine kinase activity
C5I45_17635	COG3850	Histidine kinase
C5I45_17640	COG0745	RESPONSE REGULATOR receiver
C5I45_17645	COG0577	efflux transmembrane transporter activity
C5I45_17650	COG1136	(ABC) transporter
C5I45_17655	COG2079	MmgE PrpD family protein
C5I45_17665	COG1126	abc transporter atp-binding protein
C5I45_17670	COG0765	amino acid transport
C5I45_17675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5I45_17690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5I45_17700	COG0697	spore germination
C5I45_17710	COG5434	Belongs to the glycosyl hydrolase 28 family
C5I45_17715	COG3104	oligopeptide transport
C5I45_17730	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C5I45_17735	COG0163	prenyltransferase activity
C5I45_17740	COG0583	DNA-binding transcription factor activity
C5I45_17745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5I45_17750	COG0765	amino acid transport
C5I45_17755	COG1126	abc transporter atp-binding protein
C5I45_17760	COG2364	Membrane
C5I45_17775	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C5I45_17780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_17785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_17790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5I45_17795	COG1733	regulation of RNA biosynthetic process
C5I45_17800	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C5I45_17805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5I45_17810	COG3209	COG3209 Rhs family protein
C5I45_17830	COG1714	RDD family
C5I45_17835	COG1063	alcohol dehydrogenase
C5I45_17840	COG0523	cobalamin synthesis protein
C5I45_17845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5I45_17850	COG2146	nitrite reductase [NAD(P)H] activity
C5I45_17855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5I45_17855	COG1587	Uroporphyrinogen-III synthase
C5I45_17865	COG2508	Transcriptional regulator
C5I45_17870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5I45_17875	COG1012	belongs to the aldehyde dehydrogenase family
C5I45_17880	COG0506	proline dehydrogenase activity
C5I45_17885	COG3541	Predicted nucleotidyltransferase
C5I45_17890	COG3458	cephalosporin-C deacetylase activity
C5I45_17895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5I45_17900	COG2271	Major facilitator Superfamily
C5I45_17905	COG1082	Xylose isomerase domain protein TIM barrel
C5I45_17910	COG1660	Displays ATPase and GTPase activities
C5I45_17925	COG3665	Urea carboxylase-associated protein
C5I45_17930	COG1113	amino acid transport
C5I45_17935	COG3403	YqcI/YcgG family
C5I45_17940	COG1280	lysine exporter protein (LysE YggA)
C5I45_17945	COG1846	Transcriptional regulator
C5I45_17950	COG2814	Major facilitator Superfamily
C5I45_17975	COG1288	antiporter activity
C5I45_17980	COG1473	amidohydrolase
C5I45_17985	COG2113	Glycine betaine
C5I45_17990	COG4176	ABC-type proline glycine betaine transport system permease component
C5I45_17995	COG0517	IMP dehydrogenase activity
C5I45_17995	COG4175	Glycine betaine
C5I45_18000	COG0477	Major facilitator Superfamily
C5I45_18005	COG3853	Toxic anion resistance protein (TelA)
C5I45_18015	COG0861	Integral membrane protein TerC family
C5I45_18020	COG2310	stress, protein
C5I45_18025	COG2310	stress, protein
C5I45_18030	COG2310	stress, protein
C5I45_18035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5I45_18040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5I45_18045	COG1121	(ABC) transporter
C5I45_18050	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5I45_18055	COG0366	Alpha amylase catalytic
C5I45_18060	COG1028	Short-chain dehydrogenase reductase Sdr
C5I45_18065	COG0457	Tetratricopeptide repeat
C5I45_18070	COG1876	peptidase activity
C5I45_18075	COG1595	DNA-templated transcription, initiation
C5I45_18080	COG1595	DNA-templated transcription, initiation
C5I45_18090	COG0667	Aldo Keto reductase
C5I45_18095	COG3012	SEC-C Motif Domain Protein
C5I45_18095	COG1405	negative regulation of cell septum assembly
C5I45_18100	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C5I45_18105	COG0252	asparaginase activity
C5I45_18110	COG1309	transcriptional regulator
C5I45_18115	COG0477	Major facilitator Superfamily
C5I45_18120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5I45_18130	COG0805	protein transport
C5I45_18135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5I45_18140	COG3540	Alkaline phosphatase
C5I45_18150	COG3773	Cell wall hydrolase
C5I45_18165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5I45_18170	COG2259	Doxx family
C5I45_18175	COG0346	lactoylglutathione lyase activity
C5I45_18180	COG0778	Nitroreductase
C5I45_18185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5I45_18195	COG3173	Aminoglycoside phosphotransferase
C5I45_18200	COG0784	Response regulator, receiver
C5I45_18205	COG4191	Histidine kinase
C5I45_18210	COG2066	Belongs to the glutaminase family
C5I45_18215	COG1115	amino acid carrier protein
C5I45_18220	COG2040	homocysteine
C5I45_18225	COG0833	amino acid
C5I45_18230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5I45_18235	COG1301	dicarboxylic acid transport
C5I45_18250	COG0688	phosphatidylethanolamine metabolic process
C5I45_18255	COG0586	Pfam SNARE associated Golgi protein
C5I45_18260	COG1183	phosphatidylcholine synthase activity
C5I45_18270	COG0371	Dehydrogenase
C5I45_18285	COG3409	Peptidoglycan-binding domain 1 protein
C5I45_18295	COG2368	4-hydroxyphenylacetate
C5I45_18310	COG2271	Major facilitator Superfamily
C5I45_18315	COG0584	glycerophosphoryl diester phosphodiesterase
C5I45_18330	COG0531	amino acid
C5I45_18370	COG1131	(ABC) transporter
C5I45_18375	COG2197	response regulator
C5I45_18380	COG4585	Histidine kinase
C5I45_18385	COG1011	Hydrolase
C5I45_18390	COG1113	amino acid transport
C5I45_18395	COG1846	Transcriptional regulator
C5I45_18400	COG1380	Effector of murein hydrolase LrgA
C5I45_18405	COG1346	cytolysis
C5I45_18445	COG4856	YbbR-like protein
C5I45_18450	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5I45_18455	COG5662	AntiSigma factor
C5I45_18460	COG1595	DNA-templated transcription, initiation
C5I45_18490	COG1683	Conserved Protein
C5I45_18495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5I45_18505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5I45_18505	COG1263	PTS System
C5I45_18510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5I45_18515	COG1472	Belongs to the glycosyl hydrolase 3 family
C5I45_18520	COG3876	Protein conserved in bacteria
C5I45_18525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5I45_18525	COG2207	Transcriptional regulator
C5I45_18530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5I45_18535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_18540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5I45_18545	COG2819	hydrolase of the alpha beta superfamily
C5I45_18550	COG0385	Bile acid
C5I45_18555	COG0659	secondary active sulfate transmembrane transporter activity
C5I45_18570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5I45_18575	COG0738	Major facilitator superfamily
C5I45_18635	COG0726	polysaccharide deacetylase
C5I45_18640	COG2194	sulfuric ester hydrolase activity
C5I45_18650	COG0489	protein tyrosine kinase activity
C5I45_18655	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5I45_18665	COG2318	DinB family
C5I45_18670	COG2226	methyltransferase
C5I45_18690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5I45_18695	COG1122	ATPase activity
C5I45_18700	COG1122	ATPase activity
C5I45_18725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5I45_18730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5I45_18740	COG0024	Methionine aminopeptidase
C5I45_18750	COG0201	protein transport
C5I45_18760	COG1841	ribosomal large subunit assembly
C5I45_18800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5I45_18810	COG0255	Belongs to the universal ribosomal protein uL29 family
C5I45_18815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5I45_18825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5I45_18830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5I45_18840	COG0089	rRNA binding
C5I45_18855	COG0051	transcription antitermination factor activity, RNA binding
C5I45_18860	COG0596	Alpha beta hydrolase
C5I45_18885	COG1358	cellular component organization or biogenesis
C5I45_18900	COG2813	Specifically methylates the guanine in position
C5I45_18905	COG0222	ribosome binding
C5I45_18920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5I45_18925	COG0250	Participates in transcription elongation, termination and antitermination
C5I45_18930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5I45_18935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5I45_18940	COG1595	DNA-templated transcription, initiation
C5I45_18945	COG3688	RNA-binding protein containing a PIN domain
C5I45_18950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5I45_18955	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C5I45_18965	COG1045	serine acetyltransferase
C5I45_18990	COG4956	integral membrane protein (PIN domain superfamily)
C5I45_18995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C5I45_19000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5I45_19010	COG1132	(ABC) transporter
C5I45_19025	COG0542	response to heat
C5I45_19035	COG3880	PFAM UvrB UvrC protein
C5I45_19040	COG4463	regulation of RNA biosynthetic process
C5I45_19120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5I45_19125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5I45_19130	COG1396	sequence-specific DNA binding
C5I45_19135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5I45_19140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5I45_19145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5I45_19150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5I45_19155	COG0512	Glutamine amidotransferase of anthranilate synthase
C5I45_19160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5I45_19165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5I45_19170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5I45_19185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5I45_19195	COG0037	tRNA processing
C5I45_19200	COG0515	serine threonine protein kinase
C5I45_19205	COG2304	oxidoreductase activity
C5I45_19210	COG2208	phosphoserine phosphatase activity
C5I45_19225	COG1098	S1 RNA binding domain
C5I45_19230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C5I45_19245	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5I45_19250	COG3956	TIGRFAM MazG family protein
C5I45_19255	COG2244	polysaccharide biosynthetic process
C5I45_19260	COG2002	toxin-antitoxin pair type II binding
C5I45_19265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5I45_19285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5I45_19300	COG0251	oxidation-reduction process
C5I45_19305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5I45_19320	COG4466	Protein conserved in bacteria
C5I45_19330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5I45_19335	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C5I45_19340	COG3583	domain protein
C5I45_19340	COG3584	3D domain protein
C5I45_19345	COG0084	hydrolase, TatD family'
C5I45_19350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5I45_19350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5I45_19355	COG2002	toxin-antitoxin pair type II binding
C5I45_19360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5I45_19370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C5I45_19380	COG1774	PSP1 C-terminal conserved region
C5I45_19385	COG0470	DNA polymerase III
C5I45_19390	COG1728	Protein conserved in bacteria
C5I45_19395	COG3870	Protein conserved in bacteria
C5I45_19405	COG1982	Orn Lys Arg decarboxylase major
C5I45_19410	COG3853	Toxic anion resistance protein (TelA)
C5I45_19415	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C5I45_19465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5I45_19470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5I45_19480	COG0590	tRNA wobble adenosine to inosine editing
C5I45_19485	COG1335	isochorismatase
C5I45_19490	COG3858	chitin binding
C5I45_19490	COG1388	LysM domain
C5I45_19495	COG1428	Deoxynucleoside kinase
C5I45_19500	COG1428	Deoxynucleoside kinase
C5I45_19510	COG1929	Belongs to the glycerate kinase type-1 family
C5I45_19530	COG1686	Belongs to the peptidase S11 family
C5I45_19535	COG0517	IMP dehydrogenase activity
C5I45_19535	COG0516	GMP reductase activity
C5I45_19570	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5I45_19575	COG0187	DNA topoisomerase II activity
C5I45_19590	COG2501	S4 domain
C5I45_19595	COG0592	DNA-directed DNA polymerase activity