locus-tag	class	description
O6U12_00005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O6U12_00010	COG0322	excinuclease ABC activity
O6U12_00015	COG2222	sugar isomerase
O6U12_00020	COG1653	transport
O6U12_00035	COG2188	Transcriptional regulator
O6U12_00040	COG3842	ATPase activity
O6U12_00045	COG0527	aspartate kinase activity
O6U12_00060	COG0072	phenylalanine-tRNA ligase activity
O6U12_00060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_00070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_00085	COG2356	endonuclease I
O6U12_00095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_00100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O6U12_00105	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O6U12_00110	COG2068	MobA-Related Protein
O6U12_00115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
O6U12_00120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O6U12_00125	COG2080	2 iron, 2 sulfur cluster binding
O6U12_00135	COG2351	hydroxyisourate hydrolase activity
O6U12_00140	COG3195	allantoin biosynthetic process
O6U12_00140	COG3648	Uricase
O6U12_00145	COG2233	PERMEase
O6U12_00150	COG2233	PERMEase
O6U12_00155	COG2508	Transcriptional regulator
O6U12_00160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O6U12_00170	COG1801	Protein of unknown function DUF72
O6U12_00175	COG0730	response to heat
O6U12_00180	COG0737	Belongs to the 5'-nucleotidase family
O6U12_00185	COG3377	Domain of unknown function (DUF1805)
O6U12_00195	COG0739	heme binding
O6U12_00200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O6U12_00210	COG4470	Protein conserved in bacteria
O6U12_00215	COG2445	Protein of unknown function DUF86
O6U12_00220	COG0647	UMP catabolic process
O6U12_00225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O6U12_00230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_00235	COG0460	homoserine dehydrogenase
O6U12_00240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O6U12_00245	COG0083	homoserine kinase activity
O6U12_00250	COG4946	Tricorn protease homolog
O6U12_00250	COG0823	Involved in the tonB-independent uptake of proteins
O6U12_00250	COG1506	peptidase
O6U12_00255	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O6U12_00260	COG4837	Protein of unknown function (DUF1462)
O6U12_00265	COG1252	NADH dehydrogenase
O6U12_00270	COG4844	belongs to the
O6U12_00275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O6U12_00280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O6U12_00285	COG0316	Belongs to the HesB IscA family
O6U12_00290	COG0456	acetyltransferase
O6U12_00295	COG2808	Putative FMN-binding domain
O6U12_00300	COG0516	GMP reductase activity
O6U12_00310	COG0492	ferredoxin-NADP+ reductase activity
O6U12_00315	COG1252	NADH dehydrogenase
O6U12_00330	COG3584	3D domain protein
O6U12_00335	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
O6U12_00340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O6U12_00345	COG2056	Na+-H+ antiporter family
O6U12_00350	COG1268	BioY protein
O6U12_00355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O6U12_00360	COG2819	hydrolase of the alpha beta superfamily
O6U12_00365	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_00370	COG1169	isochorismate synthase
O6U12_00375	COG1021	2,3-dihydroxybenzoate-AMP ligase
O6U12_00380	COG3433	isochorismatase activity
O6U12_00380	COG1535	isochorismatase
O6U12_00385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_00390	COG3251	PFAM MbtH domain protein
O6U12_00395	COG5634	Uncharacterized conserved protein (DUF2278)
O6U12_00400	COG0686	Belongs to the AlaDH PNT family
O6U12_00405	COG2508	Transcriptional regulator
O6U12_00405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O6U12_00410	COG4842	Belongs to the WXG100 family
O6U12_00415	COG5417	Belongs to the EsaB family
O6U12_00420	COG4499	WXG100 protein secretion system (Wss), protein YukC
O6U12_00425	COG1674	ftsk spoiiie
O6U12_00425	COG0433	COG0433 Predicted ATPase
O6U12_00430	COG1511	domain protein
O6U12_00440	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_00445	COG1418	mRNA catabolic process
O6U12_00460	COG0628	permease
O6U12_00475	COG5506	Protein of unknown function (DUF1694)
O6U12_00480	COG1335	isochorismatase
O6U12_00485	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O6U12_00490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O6U12_00510	COG0142	geranyltranstransferase activity
O6U12_00520	COG4585	Histidine kinase
O6U12_00525	COG2197	response regulator
O6U12_00530	COG2050	protein possibly involved in aromatic compounds catabolism
O6U12_00535	COG1320	monovalent cation:proton antiporter activity
O6U12_00540	COG2212	antiporter activity
O6U12_00545	COG1863	multisubunit Na H antiporter MnhE subunit
O6U12_00550	COG0651	ATP synthesis coupled electron transport
O6U12_00555	COG1006	Multisubunit Na H antiporter MnhC subunit
O6U12_00560	COG2111	Na H antiporter
O6U12_00565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O6U12_00565	COG2111	Na H antiporter
O6U12_00575	COG3493	citrate carrier protein
O6U12_00585	COG1079	Belongs to the binding-protein-dependent transport system permease family
O6U12_00590	COG4603	Belongs to the binding-protein-dependent transport system permease family
O6U12_00595	COG3845	ABC transporter
O6U12_00600	COG1744	ABC transporter substrate-binding protein PnrA-like
O6U12_00605	COG4565	transcriptional regulatory protein
O6U12_00610	COG3290	protein histidine kinase activity
O6U12_00620	COG3011	Protein conserved in bacteria
O6U12_00625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_00630	COG2814	Major facilitator Superfamily
O6U12_00640	COG5018	Exonuclease
O6U12_00650	COG2205	protein histidine kinase activity
O6U12_00665	COG2267	carboxylic ester hydrolase activity
O6U12_00670	COG1522	sequence-specific DNA binding
O6U12_00675	COG0436	Aminotransferase
O6U12_00680	COG1098	S1 RNA binding domain
O6U12_00685	COG2155	Conserved Protein
O6U12_00690	COG1979	alcohol dehydrogenase
O6U12_00695	COG1979	alcohol dehydrogenase
O6U12_00700	COG0166	Belongs to the GPI family
O6U12_00715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O6U12_00730	COG2738	Putative neutral zinc metallopeptidase
O6U12_00735	COG1253	flavin adenine dinucleotide binding
O6U12_00740	COG0366	Alpha amylase catalytic
O6U12_00750	COG0432	Pfam Uncharacterised protein family UPF0047
O6U12_00770	COG0840	transmembrane signaling receptor activity
O6U12_00775	COG0840	transmembrane signaling receptor activity
O6U12_00780	COG0840	transmembrane signaling receptor activity
O6U12_00785	COG0840	transmembrane signaling receptor activity
O6U12_00790	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_00790	COG3347	Dehydrogenase
O6U12_00795	COG1349	DNA-binding transcription factor activity
O6U12_00800	COG1070	Carbohydrate kinase
O6U12_00805	COG3254	rhamnose metabolic process
O6U12_00810	COG4806	L-rhamnose isomerase
O6U12_00815	COG0673	inositol 2-dehydrogenase activity
O6U12_00820	COG0628	permease
O6U12_00825	COG1968	undecaprenyl-diphosphatase activity
O6U12_00835	COG5553	Cysteine dioxygenase type I
O6U12_00840	COG0477	Major facilitator Superfamily
O6U12_00845	COG1705	Flagellar rod assembly protein muramidase FlgJ
O6U12_00850	COG4682	membrane
O6U12_00855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O6U12_00860	COG0569	domain protein
O6U12_00875	COG1510	regulation of RNA biosynthetic process
O6U12_00880	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_00885	COG1454	alcohol dehydrogenase
O6U12_00895	COG2318	DinB family
O6U12_00900	COG1585	Membrane protein implicated in regulation of membrane protease activity
O6U12_00905	COG2268	Band 7 protein
O6U12_00910	COG1247	-acetyltransferase
O6U12_00915	COG3859	Proton-coupled thiamine transporter YuaJ
O6U12_01040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O6U12_01045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O6U12_01050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O6U12_01055	COG0297	glycogen (starch) synthase activity
O6U12_01060	COG0058	SHG alpha-glucan phosphorylase activity
O6U12_01065	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
O6U12_01070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_01075	COG0438	transferase activity, transferring glycosyl groups
O6U12_01080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_01090	COG0438	transferase activity, transferring glycosyl groups
O6U12_01095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O6U12_01100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O6U12_01105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O6U12_01110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O6U12_01115	COG1169	isochorismate synthase
O6U12_01120	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O6U12_01125	COG0596	Alpha beta hydrolase
O6U12_01130	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O6U12_01135	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_01140	COG4948	Mandelate Racemase Muconate Lactonizing
O6U12_01145	COG0803	Belongs to the bacterial solute-binding protein 9 family
O6U12_01150	COG1121	(ABC) transporter
O6U12_01155	COG1321	iron dependent repressor
O6U12_01155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O6U12_01160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O6U12_01170	COG1294	oxidase, subunit
O6U12_01175	COG1271	oxidase subunit
O6U12_01180	COG0254	rRNA binding
O6U12_01185	COG0288	reversible hydration of carbon dioxide
O6U12_01190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O6U12_01195	COG1854	S-ribosylhomocysteine lyase activity
O6U12_01210	COG0783	Belongs to the Dps family
O6U12_01215	COG4824	toxin secretion phage lysis holin
O6U12_01220	COG0494	nUDIX hydrolase
O6U12_01225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O6U12_01230	COG1116	anion transmembrane transporter activity
O6U12_01235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O6U12_01240	COG1506	peptidase
O6U12_01250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O6U12_01255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O6U12_01260	COG0367	asparagine synthase
O6U12_01265	COG1113	amino acid transport
O6U12_01270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O6U12_01275	COG2267	carboxylic ester hydrolase activity
O6U12_01285	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O6U12_01290	COG1242	4 iron, 4 sulfur cluster binding
O6U12_01305	COG1725	Transcriptional regulator
O6U12_01310	COG1131	(ABC) transporter
O6U12_01325	COG1136	(ABC) transporter
O6U12_01330	COG0577	efflux transmembrane transporter activity
O6U12_01335	COG0745	RESPONSE REGULATOR receiver
O6U12_01340	COG2205	protein histidine kinase activity
O6U12_01345	COG1136	(ABC) transporter
O6U12_01350	COG0577	efflux transmembrane transporter activity
O6U12_01355	COG2433	Pfam Transposase IS66
O6U12_01360	COG2814	Major facilitator Superfamily
O6U12_01365	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_01365	COG2202	Pas domain
O6U12_01375	COG0495	leucyl-tRNA aminoacylation
O6U12_01380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O6U12_01385	COG1486	melibiose metabolic process
O6U12_01390	COG0395	ABC-type sugar transport system, permease component
O6U12_01395	COG1175	transmembrane transport
O6U12_01400	COG1653	transport
O6U12_01405	COG1609	Transcriptional regulator
O6U12_01410	COG1073	alpha beta
O6U12_01420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O6U12_01425	COG0156	8-amino-7-oxononanoate synthase activity
O6U12_01435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O6U12_01440	COG2124	cytochrome p450
O6U12_01445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O6U12_01450	COG0395	ABC-type sugar transport system, permease component
O6U12_01455	COG1653	transport
O6U12_01460	COG2207	Transcriptional regulator
O6U12_01465	COG4209	transmembrane transport
O6U12_01470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
O6U12_01475	COG1653	transport
O6U12_01480	COG0673	inositol 2-dehydrogenase activity
O6U12_01485	COG5578	integral membrane protein
O6U12_01495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O6U12_01500	COG2081	HI0933 family
O6U12_01505	COG2244	polysaccharide biosynthetic process
O6U12_01510	COG1187	pseudouridine synthase activity
O6U12_01515	COG1349	DNA-binding transcription factor activity
O6U12_01520	COG1131	(ABC) transporter
O6U12_01525	COG4473	ABC transporter
O6U12_01530	COG2252	PERMEase
O6U12_01535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_01540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O6U12_01545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O6U12_01555	COG1597	lipid kinase activity
O6U12_01560	COG1523	belongs to the glycosyl hydrolase 13 family
O6U12_01565	COG0510	thiamine kinase activity
O6U12_01575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O6U12_01580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_01585	COG0281	malic enzyme
O6U12_01590	COG5584	Small secreted protein
O6U12_01595	COG1363	Peptidase, m42
O6U12_01610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_01615	COG4848	Belongs to the UPF0354 family
O6U12_01620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_01625	COG1674	ftsk spoiiie
O6U12_01630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O6U12_01635	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
O6U12_01640	COG4980	gas vesicle protein
O6U12_01645	COG3118	belongs to the thioredoxin family
O6U12_01650	COG1605	Chorismate mutase
O6U12_01650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O6U12_01655	COG1609	Transcriptional regulator
O6U12_01660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O6U12_01665	COG1360	Flagellar Motor Protein
O6U12_01670	COG0123	including yeast histone deacetylase and acetoin utilization protein
O6U12_01675	COG0517	IMP dehydrogenase activity
O6U12_01680	COG0454	-acetyltransferase
O6U12_01685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O6U12_01690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O6U12_01705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O6U12_01735	COG3645	SOS response
O6U12_01735	COG3646	Phage regulatory protein
O6U12_01760	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_01780	COG1598	PFAM Uncharacterised protein family UPF0150
O6U12_01885	COG5280	Phage tail tape measure protein TP901
O6U12_01885	COG3953	SLT domain
O6U12_01895	COG1705	Flagellar rod assembly protein muramidase FlgJ
O6U12_01900	COG5434	Belongs to the glycosyl hydrolase 28 family
O6U12_01925	COG4824	toxin secretion phage lysis holin
O6U12_01930	COG1388	LysM domain
O6U12_01930	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_01930	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_01945	COG0457	Tetratricopeptide repeat
O6U12_01955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O6U12_01960	COG2199	diguanylate cyclase activity
O6U12_01960	COG2203	Gaf domain
O6U12_01965	COG1956	GAF domain-containing protein
O6U12_01970	COG1309	transcriptional regulator
O6U12_01975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O6U12_01980	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
O6U12_01985	COG1114	Component of the transport system for branched-chain amino acids
O6U12_01990	COG1104	cysteine desulfurase activity
O6U12_01995	COG0301	tRNA thio-modification
O6U12_02005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O6U12_02010	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O6U12_02015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O6U12_02020	COG0616	signal peptide processing
O6U12_02025	COG1714	RDD family
O6U12_02035	COG3874	Sporulation protein YtfJ
O6U12_02040	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O6U12_02045	COG0827	DNA restriction-modification system
O6U12_02055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O6U12_02060	COG0521	Mo-molybdopterin cofactor biosynthetic process
O6U12_02065	COG0137	argininosuccinate synthase activity
O6U12_02070	COG0165	Argininosuccinate lyase
O6U12_02080	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_02085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O6U12_02090	COG0583	DNA-binding transcription factor activity
O6U12_02095	COG0454	-acetyltransferase
O6U12_02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_02105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_02110	COG0765	amino acid transport
O6U12_02115	COG0765	amino acid transport
O6U12_02120	COG1126	abc transporter atp-binding protein
O6U12_02125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_02130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O6U12_02135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_02140	COG0196	riboflavin kinase activity
O6U12_02150	COG0730	response to heat
O6U12_02155	COG4109	DRTGG domain
O6U12_02165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O6U12_02185	COG0587	DNA-directed DNA polymerase activity
O6U12_02190	COG0281	malic enzyme
O6U12_02195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O6U12_02200	COG0825	malonyl-CoA metabolic process
O6U12_02205	COG0205	6-phosphofructokinase activity
O6U12_02210	COG0469	pyruvate kinase activity
O6U12_02215	COG3030	protein affecting phage T7 exclusion by the F plasmid
O6U12_02220	COG0628	permease
O6U12_02225	COG2707	UPF0756 membrane protein
O6U12_02230	COG0372	Belongs to the citrate synthase family
O6U12_02235	COG0538	isocitrate dehydrogenase activity
O6U12_02240	COG0039	L-malate dehydrogenase activity
O6U12_02245	COG0745	RESPONSE REGULATOR receiver
O6U12_02250	COG5002	protein histidine kinase activity
O6U12_02255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O6U12_02255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O6U12_02260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O6U12_02265	COG1971	Probably functions as a manganese efflux pump
O6U12_02270	COG0237	dephospho-CoA kinase activity
O6U12_02275	COG0656	L-ascorbic acid biosynthetic process
O6U12_02280	COG2814	Major facilitator Superfamily
O6U12_02285	COG1733	regulation of RNA biosynthetic process
O6U12_02290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O6U12_02300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O6U12_02305	COG3611	Membrane attachment protein
O6U12_02310	COG1484	DNA-dependent DNA replication
O6U12_02315	COG0398	Pfam SNARE associated Golgi protein
O6U12_02325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O6U12_02330	COG1011	Hydrolase
O6U12_02335	COG3275	phosphorelay sensor kinase activity
O6U12_02340	COG3279	Response regulator of the LytR AlgR family
O6U12_02345	COG1380	Effector of murein hydrolase LrgA
O6U12_02350	COG1346	cytolysis
O6U12_02360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O6U12_02365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O6U12_02370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O6U12_02375	COG3326	Membrane
O6U12_02385	COG1363	Peptidase, m42
O6U12_02390	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_02395	COG2160	L-arabinose isomerase activity
O6U12_02400	COG1069	ribulokinase activity
O6U12_02405	COG0235	Class ii aldolase
O6U12_02410	COG0647	UMP catabolic process
O6U12_02415	COG0371	Dehydrogenase
O6U12_02420	COG1653	transport
O6U12_02425	COG1175	transmembrane transport
O6U12_02430	COG0395	ABC-type sugar transport system, permease component
O6U12_02435	COG3534	alpha-L-arabinofuranosidase
O6U12_02440	COG1966	Carbon starvation protein
O6U12_02450	COG0346	lactoylglutathione lyase activity
O6U12_02455	COG0247	lactate metabolic process
O6U12_02460	COG0277	FAD linked oxidase domain protein
O6U12_02465	COG3835	regulator
O6U12_02475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O6U12_02485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O6U12_02490	COG0072	phenylalanine-tRNA ligase activity
O6U12_02490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_02495	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O6U12_02500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O6U12_02505	COG1286	toxin biosynthetic process
O6U12_02510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O6U12_02510	COG1796	DNA polymerase
O6U12_02515	COG1193	negative regulation of DNA recombination
O6U12_02520	COG3766	membrane
O6U12_02525	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_02530	COG1309	transcriptional regulator
O6U12_02535	COG1024	Enoyl-CoA hydratase
O6U12_02540	COG2086	electron transfer activity
O6U12_02545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O6U12_02550	COG3534	alpha-L-arabinofuranosidase
O6U12_02555	COG3118	belongs to the thioredoxin family
O6U12_02560	COG0322	excinuclease ABC activity
O6U12_02565	COG0527	aspartate kinase activity
O6U12_02570	COG1719	4-vinyl reductase, 4VR
O6U12_02575	COG2009	succinate dehydrogenase
O6U12_02580	COG1053	succinate dehydrogenase
O6U12_02585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O6U12_02590	COG0824	Thioesterase
O6U12_02595	COG2197	response regulator
O6U12_02600	COG2856	Zn peptidase
O6U12_02610	COG1525	nuclease
O6U12_02615	COG3620	sequence-specific DNA binding
O6U12_02640	COG3646	Phage regulatory protein
O6U12_02640	COG3645	SOS response
O6U12_02670	COG5377	YqaJ viral recombinase family
O6U12_02675	COG3723	Recombinational DNA repair protein, rece pathway
O6U12_02680	COG3935	DnaD domain protein
O6U12_02685	COG1484	DNA-dependent DNA replication
O6U12_02695	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
O6U12_02725	COG1595	DNA-templated transcription, initiation
O6U12_02745	COG5484	DNA packaging
O6U12_02820	COG3953	SLT domain
O6U12_02820	COG5280	Phage tail tape measure protein TP901
O6U12_02825	COG0791	NLP P60 protein
O6U12_02825	COG1388	LysM domain
O6U12_02875	COG4824	toxin secretion phage lysis holin
O6U12_02880	COG1388	LysM domain
O6U12_02880	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_02880	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_02905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_02915	COG1846	Transcriptional regulator
O6U12_02920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O6U12_02925	COG5401	PFAM Sporulation and spore germination
O6U12_02930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O6U12_02935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O6U12_02940	COG0622	Phosphoesterase
O6U12_02950	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
O6U12_02955	COG0454	-acetyltransferase
O6U12_02965	COG0028	Belongs to the TPP enzyme family
O6U12_02970	COG0440	acetolactate synthase activity
O6U12_02975	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O6U12_02980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O6U12_02985	COG0473	3-isopropylmalate dehydrogenase activity
O6U12_02990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O6U12_02995	COG0066	3-isopropylmalate dehydratase activity
O6U12_03005	COG0457	Tetratricopeptide repeat
O6U12_03005	COG1477	protein flavinylation
O6U12_03010	COG0544	peptidyl-prolyl cis-trans isomerase activity
O6U12_03015	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O6U12_03020	COG0470	DNA polymerase III
O6U12_03020	COG1067	ATP-dependent peptidase activity
O6U12_03025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O6U12_03030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O6U12_03040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O6U12_03045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O6U12_03050	COG0181	hydroxymethylbilane synthase activity
O6U12_03055	COG1587	Uroporphyrinogen-III synthase
O6U12_03060	COG0113	porphobilinogen synthase activity
O6U12_03065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O6U12_03070	COG1388	LysM domain
O6U12_03075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_03085	COG0525	valine-tRNA ligase activity
O6U12_03090	COG0285	dihydrofolate synthase activity
O6U12_03095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O6U12_03105	COG0424	maF-like protein
O6U12_03110	COG2003	Belongs to the UPF0758 family
O6U12_03115	COG1077	Cell shape determining protein MreB Mrl
O6U12_03125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O6U12_03130	COG0850	regulation of cytokinetic process
O6U12_03135	COG2894	cell division
O6U12_03140	COG0739	heme binding
O6U12_03145	COG1994	Peptidase M50
O6U12_03150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O6U12_03155	COG2868	ribosomal protein
O6U12_03160	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O6U12_03170	COG3290	protein histidine kinase activity
O6U12_03175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O6U12_03180	COG4492	Belongs to the UPF0735 family
O6U12_03185	COG0077	Prephenate dehydratase
O6U12_03190	COG1827	regulation of RNA biosynthetic process
O6U12_03195	COG1104	cysteine desulfurase activity
O6U12_03200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O6U12_03205	COG0157	Belongs to the NadC ModD family
O6U12_03210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O6U12_03215	COG1388	LysM domain
O6U12_03225	COG0217	transcriptional regulatory protein
O6U12_03230	COG1115	amino acid carrier protein
O6U12_03255	COG2112	serine threonine protein kinase
O6U12_03260	COG0673	inositol 2-dehydrogenase activity
O6U12_03265	COG2814	Major facilitator Superfamily
O6U12_03275	COG0632	four-way junction helicase activity
O6U12_03280	COG2255	four-way junction helicase activity
O6U12_03290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O6U12_03295	COG0343	queuine tRNA-ribosyltransferase activity
O6U12_03300	COG1862	Preprotein translocase
O6U12_03310	COG2323	membrane
O6U12_03315	COG2244	polysaccharide biosynthetic process
O6U12_03325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O6U12_03325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O6U12_03330	COG0490	domain, Protein
O6U12_03335	COG5416	Lipopolysaccharide assembly protein A domain
O6U12_03340	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O6U12_03340	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
O6U12_03345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O6U12_03350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O6U12_03355	COG1490	D-aminoacyl-tRNA deacylase activity
O6U12_03360	COG4991	sh3 domain protein
O6U12_03360	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_03360	COG3103	Sh3 type 3 domain protein
O6U12_03370	COG0124	histidyl-tRNA synthetase
O6U12_03375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O6U12_03385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O6U12_03390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O6U12_03395	COG1959	2 iron, 2 sulfur cluster binding
O6U12_03400	COG1104	cysteine desulfurase activity
O6U12_03405	COG0482	sulfurtransferase activity
O6U12_03410	COG0457	Tetratricopeptide repeat
O6U12_03415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O6U12_03420	COG3881	PFAM PRC-barrel domain
O6U12_03435	COG0765	amino acid transport
O6U12_03440	COG0765	amino acid transport
O6U12_03445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_03450	COG1126	abc transporter atp-binding protein
O6U12_03455	COG0628	permease
O6U12_03460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O6U12_03465	COG4472	Bacterial protein of unknown function (DUF965)
O6U12_03470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O6U12_03475	COG3906	Belongs to the UPF0473 family
O6U12_03480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O6U12_03485	COG4122	O-methyltransferase activity
O6U12_03490	COG0826	peptidase U32
O6U12_03495	COG0826	peptidase U32
O6U12_03500	COG0572	uridine kinase
O6U12_03505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O6U12_03510	COG0768	penicillin binding
O6U12_03525	COG2226	methyltransferase
O6U12_03530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O6U12_03535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O6U12_03540	COG0626	cystathionine gamma-synthase activity
O6U12_03550	COG2427	Protein of unknown function (DUF1641)
O6U12_03555	COG3383	formate dehydrogenase (NAD+) activity
O6U12_03560	COG5609	conserved protein (DUF2294)
O6U12_03565	COG2116	formate transmembrane transporter activity
O6U12_03580	COG2226	methyltransferase
O6U12_03585	COG1309	transcriptional regulator
O6U12_03590	COG2124	cytochrome p450
O6U12_03590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O6U12_03600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O6U12_03600	COG2755	lipolytic protein G-D-S-L family
O6U12_03610	COG1595	DNA-templated transcription, initiation
O6U12_03615	COG1378	Sugar-specific transcriptional regulator TrmB
O6U12_03620	COG1280	lysine exporter protein (LysE YggA)
O6U12_03625	COG1113	amino acid transport
O6U12_03635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O6U12_03635	COG3933	PFAM sigma-54 factor interaction domain-containing protein
O6U12_03640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_03645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_03650	COG3715	PTS system
O6U12_03655	COG3716	PTS system mannose fructose sorbose family IID component
O6U12_03665	COG1621	beta-fructofuranosidase activity
O6U12_03670	COG0693	protein deglycase activity
O6U12_03675	COG1064	alcohol dehydrogenase
O6U12_03685	COG0789	Transcriptional regulator
O6U12_03695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O6U12_03700	COG2070	2-Nitropropane dioxygenase
O6U12_03710	COG3328	transposase activity
O6U12_03715	COG2318	DinB family
O6U12_03750	COG2124	cytochrome p450
O6U12_03755	COG2732	(Barnase) inhibitor
O6U12_03765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
O6U12_03770	COG1687	branched-chain amino acid
O6U12_03790	COG1230	cation diffusion facilitator family transporter
O6U12_03820	COG0583	DNA-binding transcription factor activity
O6U12_03855	COG1253	flavin adenine dinucleotide binding
O6U12_03860	COG0456	acetyltransferase
O6U12_03865	COG2814	Major facilitator Superfamily
O6U12_03870	COG0789	Transcriptional regulator
O6U12_03870	COG4978	Transcriptional regulator
O6U12_03885	COG0662	Cupin 2, conserved barrel domain protein
O6U12_03895	COG1937	Protein conserved in bacteria
O6U12_03900	COG2210	Belongs to the sulfur carrier protein TusA family
O6U12_03910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O6U12_03910	COG0425	Belongs to the sulfur carrier protein TusA family
O6U12_03925	COG0425	Belongs to the sulfur carrier protein TusA family
O6U12_03930	COG0730	response to heat
O6U12_03935	COG4124	Belongs to the glycosyl hydrolase 26 family
O6U12_03950	COG3328	transposase activity
O6U12_03960	COG2856	Zn peptidase
O6U12_03965	COG0563	adenylate kinase activity
O6U12_03975	COG3328	transposase activity
O6U12_04000	COG4824	toxin secretion phage lysis holin
O6U12_04005	COG1388	LysM domain
O6U12_04005	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_04005	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_04015	COG4282	regulation of fungal-type cell wall biogenesis
O6U12_04055	COG0457	Tetratricopeptide repeat
O6U12_04085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_04090	COG0477	Major facilitator Superfamily
O6U12_04130	COG0398	Pfam SNARE associated Golgi protein
O6U12_04135	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_04135	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_04140	COG2755	lipolytic protein G-D-S-L family
O6U12_04150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
O6U12_04155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O6U12_04160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O6U12_04165	COG1534	Rna-binding protein
O6U12_04170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O6U12_04175	COG1713	HD superfamily hydrolase involved in NAD metabolism
O6U12_04180	COG0799	negative regulation of ribosome biogenesis
O6U12_04185	COG2226	methyltransferase
O6U12_04190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_04195	COG1555	photosystem II stabilization
O6U12_04195	COG1596	polysaccharide export
O6U12_04200	COG2131	deaminase
O6U12_04205	COG0658	competence protein
O6U12_04205	COG2333	competence protein COMEC
O6U12_04220	COG1466	dna polymerase III delta subunit
O6U12_04225	COG0268	Binds directly to 16S ribosomal RNA
O6U12_04230	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
O6U12_04235	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_04245	COG0481	GTPase activity
O6U12_04250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O6U12_04255	COG1420	regulation of RNA biosynthetic process
O6U12_04260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O6U12_04265	COG0443	Heat shock 70 kDa protein
O6U12_04270	COG0484	heat shock protein binding
O6U12_04275	COG2264	protein methyltransferase activity
O6U12_04280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O6U12_04285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O6U12_04290	COG1283	sodium-dependent phosphate transmembrane transporter activity
O6U12_04300	COG1610	YqeY-like protein
O6U12_04305	COG1030	water channel activity
O6U12_04310	COG4864	UPF0365 protein
O6U12_04325	COG0561	phosphatase activity
O6U12_04330	COG1702	phosphate starvation-inducible protein PhoH
O6U12_04335	COG1480	7TM receptor with intracellular HD hydrolase
O6U12_04340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O6U12_04345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O6U12_04350	COG0295	cytidine deaminase activity
O6U12_04355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O6U12_04365	COG1381	Involved in DNA repair and RecF pathway recombination
O6U12_04370	COG0752	glycyl-tRNA synthetase alpha subunit
O6U12_04375	COG0751	glycine-tRNA ligase activity
O6U12_04380	COG0517	IMP dehydrogenase activity
O6U12_04385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O6U12_04390	COG1671	Belongs to the UPF0178 family
O6U12_04395	COG0358	DNA primase activity
O6U12_04400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O6U12_04405	COG2010	Cytochrome c
O6U12_04410	COG2384	SAM-dependent methyltransferase
O6U12_04415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O6U12_04420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O6U12_04430	COG0513	Belongs to the DEAD box helicase family
O6U12_04435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O6U12_04445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_04450	COG0735	belongs to the Fur family
O6U12_04455	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
O6U12_04460	COG4709	membrane
O6U12_04465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O6U12_04470	COG1388	LysM domain
O6U12_04475	COG5521	maltodextrose utilization protein MalA
O6U12_04480	COG2839	Protein conserved in bacteria
O6U12_04485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O6U12_04490	COG0477	Major facilitator Superfamily
O6U12_04495	COG0768	penicillin binding
O6U12_04500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O6U12_04505	COG0573	inorganic phosphate transmembrane transporter activity
O6U12_04510	COG0581	inorganic phosphate transmembrane transporter activity
O6U12_04515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O6U12_04520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O6U12_04525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O6U12_04540	COG0438	transferase activity, transferring glycosyl groups
O6U12_04550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O6U12_04560	COG0457	Tetratricopeptide repeat
O6U12_04560	COG0705	Rhomboid family
O6U12_04565	COG4483	Protein conserved in bacteria
O6U12_04570	COG1940	carbohydrate kinase activity
O6U12_04575	COG1368	sulfuric ester hydrolase activity
O6U12_04580	COG2866	Carboxypeptidase
O6U12_04590	COG0011	TIGRFAM Protein of
O6U12_04600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_04610	COG1393	Belongs to the ArsC family
O6U12_04620	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_04625	COG1253	flavin adenine dinucleotide binding
O6U12_04630	COG0598	Magnesium transport protein CorA
O6U12_04635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O6U12_04640	COG1459	type II secretion system
O6U12_04645	COG4537	Required for transformation and DNA binding
O6U12_04650	COG4970	Tfp pilus assembly protein FimT
O6U12_04660	COG4940	Competence protein ComGF
O6U12_04685	COG0681	Belongs to the peptidase S26 family
O6U12_04695	COG1396	sequence-specific DNA binding
O6U12_04710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O6U12_04715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O6U12_04720	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O6U12_04725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O6U12_04730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O6U12_04735	COG0095	Lipoate-protein ligase
O6U12_04740	COG1321	iron dependent repressor
O6U12_04745	COG1752	Esterase of the alpha-beta hydrolase superfamily
O6U12_04755	COG3872	metal-dependent enzyme
O6U12_04765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O6U12_04770	COG0006	proline dipeptidase activity
O6U12_04775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O6U12_04785	COG3854	ATPases associated with a variety of cellular activities
O6U12_04825	COG0511	ligase activity, forming carbon-carbon bonds
O6U12_04830	COG0439	Biotin carboxylase
O6U12_04835	COG1302	Protein conserved in bacteria
O6U12_04840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O6U12_04845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O6U12_04850	COG1570	exodeoxyribonuclease VII activity
O6U12_04855	COG1722	exodeoxyribonuclease VII activity
O6U12_04860	COG0142	geranyltranstransferase activity
O6U12_04865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O6U12_04870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O6U12_04875	COG1438	arginine binding
O6U12_04880	COG0497	DNA recombination
O6U12_04885	COG0750	zinc metalloprotease
O6U12_04890	COG0745	RESPONSE REGULATOR receiver
O6U12_04895	COG1902	pentaerythritol trinitrate reductase activity
O6U12_04910	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_04915	COG0584	glycerophosphoryl diester phosphodiesterase
O6U12_04920	COG0183	Belongs to the thiolase family
O6U12_04925	COG1250	3-hydroxyacyl-CoA dehydrogenase
O6U12_04930	COG1960	acyl-CoA dehydrogenase activity
O6U12_04935	COG0372	Belongs to the citrate synthase family
O6U12_04940	COG2079	MmgE PrpD family protein
O6U12_04945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O6U12_04955	COG3290	protein histidine kinase activity
O6U12_04955	COG3829	transcription factor binding
O6U12_04960	COG0280	phosphate acetyltransferase
O6U12_04965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O6U12_04970	COG3426	butyrate kinase activity
O6U12_04975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O6U12_04980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O6U12_04985	COG0022	dehydrogenase e1 component
O6U12_04990	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_04995	COG0789	Transcriptional regulator
O6U12_04995	COG4978	Transcriptional regulator
O6U12_05000	COG2814	Major facilitator Superfamily
O6U12_05005	COG1597	lipid kinase activity
O6U12_05015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_05020	COG0765	amino acid transport
O6U12_05025	COG1126	abc transporter atp-binding protein
O6U12_05030	COG4129	membrane
O6U12_05035	COG1376	ErfK ybiS ycfS ynhG family protein
O6U12_05045	COG0346	lactoylglutathione lyase activity
O6U12_05050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O6U12_05055	COG2195	Cleaves the N-terminal amino acid of tripeptides
O6U12_05065	COG3361	conserved protein (COG2071)
O6U12_05070	COG0706	membrane insertase activity
O6U12_05080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O6U12_05085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O6U12_05090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O6U12_05095	COG1234	tRNA 3'-trailer cleavage
O6U12_05110	COG0596	Alpha beta hydrolase
O6U12_05115	COG1902	pentaerythritol trinitrate reductase activity
O6U12_05120	COG4187	Peptidase family M20/M25/M40
O6U12_05125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_05130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_05135	COG0300	oxidoreductase activity
O6U12_05140	COG3048	D-serine ammonia-lyase activity
O6U12_05145	COG1072	(Pantothenic acid kinase))
O6U12_05150	COG0346	lactoylglutathione lyase activity
O6U12_05160	COG2211	Major facilitator Superfamily
O6U12_05170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O6U12_05180	COG0456	acetyltransferase
O6U12_05185	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_05190	COG0456	acetyltransferase
O6U12_05190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O6U12_05195	COG4918	Iron-sulphur cluster biosynthesis
O6U12_05205	COG1073	alpha beta
O6U12_05215	COG0667	Aldo Keto reductase
O6U12_05225	COG0494	nUDIX hydrolase
O6U12_05230	COG1379	DNA repair
O6U12_05235	COG1396	sequence-specific DNA binding
O6U12_05240	COG0252	asparaginase activity
O6U12_05245	COG1027	Aspartate ammonia-lyase
O6U12_05250	COG1757	Na H antiporter
O6U12_05255	COG0281	malic enzyme
O6U12_05265	COG1300	Membrane
O6U12_05270	COG0735	belongs to the Fur family
O6U12_05280	COG4974	Belongs to the 'phage' integrase family
O6U12_05285	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O6U12_05290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O6U12_05295	COG1686	Belongs to the peptidase S11 family
O6U12_05300	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_05305	COG2172	sigma factor antagonist activity
O6U12_05310	COG1191	sigma factor activity
O6U12_05330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_05345	COG0697	spore germination
O6U12_05350	COG0019	diaminopimelate decarboxylase activity
O6U12_05355	COG4086	secreted protein
O6U12_05360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O6U12_05380	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
O6U12_05390	COG0681	Belongs to the peptidase S26 family
O6U12_05400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O6U12_05400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O6U12_05405	COG0307	riboflavin synthase, alpha
O6U12_05410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O6U12_05410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O6U12_05415	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O6U12_05420	COG0456	acetyltransferase
O6U12_05425	COG1547	Domain of unknown function (DUF309)
O6U12_05430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O6U12_05435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O6U12_05445	COG1686	Belongs to the peptidase S11 family
O6U12_05450	COG2715	membrane protein required for spore maturation
O6U12_05455	COG0700	Nucleoside recognition
O6U12_05460	COG1187	pseudouridine synthase activity
O6U12_05465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_05470	COG1333	cytochrome c biogenesis protein
O6U12_05475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O6U12_05480	COG0745	RESPONSE REGULATOR receiver
O6U12_05485	COG5002	protein histidine kinase activity
O6U12_05490	COG1595	DNA-templated transcription, initiation
O6U12_05500	COG0710	3-dehydroquinate dehydratase activity
O6U12_05505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O6U12_05510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
O6U12_05515	COG1141	Ferredoxin
O6U12_05520	COG4955	Helix-turn-helix domain
O6U12_05525	COG0514	ATP-dependent DNA helicase (RecQ)
O6U12_05530	COG1266	CAAX protease self-immunity
O6U12_05535	COG1388	LysM domain
O6U12_05545	COG1408	metallophosphoesterase
O6U12_05550	COG4862	establishment of competence for transformation
O6U12_05555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O6U12_05560	COG0492	ferredoxin-NADP+ reductase activity
O6U12_05565	COG2339	peptidase activity
O6U12_05570	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_05570	COG3773	Cell wall hydrolase
O6U12_05575	COG2959	enzyme of heme biosynthesis
O6U12_05580	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
O6U12_05590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O6U12_05595	COG0539	negative regulation of cytoplasmic translation
O6U12_05600	COG1304	FMN binding
O6U12_05630	COG1160	GTP binding
O6U12_05635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O6U12_05650	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O6U12_05655	COG0776	regulation of translation
O6U12_05660	COG0302	gtp cyclohydrolase
O6U12_05670	COG0142	geranyltranstransferase activity
O6U12_05675	COG2226	methyltransferase
O6U12_05680	COG0142	geranyltranstransferase activity
O6U12_05685	COG0105	UTP biosynthetic process
O6U12_05690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O6U12_05695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O6U12_05700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O6U12_05705	COG4401	Chorismate mutase type I
O6U12_05710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O6U12_05715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O6U12_05725	COG0135	phosphoribosylanthranilate isomerase activity
O6U12_05730	COG0133	tryptophan synthase activity
O6U12_05735	COG0159	tryptophan synthase activity
O6U12_05745	COG0287	Prephenate dehydrogenase
O6U12_05750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O6U12_05755	COG0457	Tetratricopeptide repeat
O6U12_05760	COG5582	Belongs to the UPF0302 family
O6U12_05770	COG0723	plastoquinol--plastocyanin reductase activity
O6U12_05775	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O6U12_05780	COG2010	Cytochrome c
O6U12_05780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O6U12_05785	COG4347	Protein of unknown function (DUF1405)
O6U12_05795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_05800	COG1694	Mazg nucleotide pyrophosphohydrolase
O6U12_05805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O6U12_05810	COG1803	Methylglyoxal synthase
O6U12_05815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O6U12_05820	COG0438	transferase activity, transferring glycosyl groups
O6U12_05825	COG0617	tRNA 3'-terminal CCA addition
O6U12_05830	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
O6U12_05830	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
O6U12_05835	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O6U12_05840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O6U12_05845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O6U12_05850	COG1199	ATP-dependent helicase activity
O6U12_05850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O6U12_05860	COG5353	protein conserved in bacteria
O6U12_05865	COG0436	Aminotransferase
O6U12_05870	COG0017	Asparaginyl-tRNA synthetase
O6U12_05875	COG3935	DnaD domain protein
O6U12_05880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O6U12_05890	COG4499	WXG100 protein secretion system (Wss), protein YukC
O6U12_05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_05895	COG3331	DNA recombination
O6U12_05930	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_05935	COG2190	(PTS) system
O6U12_05940	COG1205	dead DEAH box helicase
O6U12_05940	COG1111	helicase
O6U12_05945	COG3359	exonuclease
O6U12_05960	COG4474	Belongs to the UPF0398 family
O6U12_05975	COG0116	Belongs to the methyltransferase superfamily
O6U12_05990	COG1199	ATP-dependent helicase activity
O6U12_05995	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_06000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
O6U12_06005	COG1609	Transcriptional regulator
O6U12_06010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_06015	COG0800	Aldolase
O6U12_06025	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O6U12_06030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O6U12_06135	COG3328	transposase activity
O6U12_06140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_06180	COG1196	nuclear chromosome segregation
O6U12_06180	COG0741	lytic transglycosylase activity
O6U12_06180	COG0739	heme binding
O6U12_06185	COG3328	transposase activity
O6U12_06190	COG0741	lytic transglycosylase activity
O6U12_06190	COG1196	nuclear chromosome segregation
O6U12_06190	COG0739	heme binding
O6U12_06195	COG2433	Pfam Transposase IS66
O6U12_06250	COG3424	synthase
O6U12_06255	COG1755	Isoprenylcysteine carboxyl methyltransferase
O6U12_06265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O6U12_06280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O6U12_06290	COG0328	RNA-DNA hybrid ribonuclease activity
O6U12_06295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O6U12_06300	COG0328	RNA-DNA hybrid ribonuclease activity
O6U12_06320	COG1278	Cold shock
O6U12_06330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O6U12_06335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O6U12_06340	COG0386	Belongs to the glutathione peroxidase family
O6U12_06350	COG1413	lyase activity
O6U12_06355	COG0129	dihydroxy-acid dehydratase activity
O6U12_06365	COG2136	Putative SAM-dependent methyltransferase
O6U12_06365	COG2521	methyltransferase
O6U12_06375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O6U12_06380	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O6U12_06385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O6U12_06390	COG0204	Acyl-transferase
O6U12_06395	COG1272	protein, Hemolysin III
O6U12_06400	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O6U12_06405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O6U12_06415	COG1999	signal sequence binding
O6U12_06420	COG2755	lipolytic protein G-D-S-L family
O6U12_06425	COG4698	Protein conserved in bacteria
O6U12_06435	COG0534	Mate efflux family protein
O6U12_06440	COG1846	Transcriptional regulator
O6U12_06445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O6U12_06450	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O6U12_06455	COG1086	Polysaccharide biosynthesis protein
O6U12_06460	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
O6U12_06465	COG4641	Protein conserved in bacteria
O6U12_06480	COG0463	Glycosyl transferase, family 2
O6U12_06485	COG0456	acetyltransferase
O6U12_06500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O6U12_06505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O6U12_06510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O6U12_06515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_06520	COG0456	acetyltransferase
O6U12_06525	COG1509	lysine 2,3-aminomutase activity
O6U12_06535	COG4479	Belongs to the UPF0346 family
O6U12_06555	COG0671	phosphoesterase, PA-phosphatase related
O6U12_06570	COG0813	purine-nucleoside phosphorylase activity
O6U12_06575	COG1876	peptidase activity
O6U12_06585	COG2226	methyltransferase
O6U12_06590	COG0793	Belongs to the peptidase S41A family
O6U12_06590	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_06595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_06605	COG0346	lactoylglutathione lyase activity
O6U12_06610	COG0400	carboxylic ester hydrolase activity
O6U12_06615	COG0778	Nitroreductase
O6U12_06620	COG1733	regulation of RNA biosynthetic process
O6U12_06625	COG1942	4-Oxalocrotonate Tautomerase
O6U12_06630	COG2610	gluconate transmembrane transporter activity
O6U12_06645	COG2962	Rard protein
O6U12_06655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O6U12_06660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O6U12_06665	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_06675	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O6U12_06680	COG1819	glycosyl
O6U12_06685	COG1388	LysM domain
O6U12_06685	COG0791	NLP P60 protein
O6U12_06690	COG2032	superoxide dismutase activity
O6U12_06695	COG0714	Associated with various cellular activities
O6U12_06700	COG4548	von Willebrand factor, type A
O6U12_06705	COG0567	Dehydrogenase, E1 component
O6U12_06710	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_06715	COG0385	Bile acid
O6U12_06720	COG0733	neurotransmitter:sodium symporter activity
O6U12_06725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O6U12_06730	COG1657	PFAM Prenyltransferase squalene oxidase
O6U12_06735	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_06760	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_06775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O6U12_06780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O6U12_06790	COG0514	ATP-dependent DNA helicase (RecQ)
O6U12_06795	COG1388	LysM domain
O6U12_06795	COG3584	3D domain protein
O6U12_06800	COG2197	response regulator
O6U12_06805	COG4585	Histidine kinase
O6U12_06810	COG3239	Fatty acid desaturase
O6U12_06815	COG1619	proteins homologs of microcin C7 resistance protein MccF
O6U12_06830	COG2322	membrane
O6U12_06840	COG0741	lytic transglycosylase activity
O6U12_06845	COG0640	Transcriptional regulator
O6U12_06855	COG2378	regulation of single-species biofilm formation
O6U12_06860	COG3708	Transcriptional regulator
O6U12_06865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_06870	COG1309	transcriptional regulator
O6U12_06875	COG0456	acetyltransferase
O6U12_06880	COG0662	Cupin 2, conserved barrel domain protein
O6U12_06880	COG2207	Transcriptional regulator
O6U12_06885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_06895	COG1231	oxidoreductase activity
O6U12_06900	COG4282	regulation of fungal-type cell wall biogenesis
O6U12_06905	COG5444	nuclease activity
O6U12_06920	COG0693	protein deglycase activity
O6U12_06925	COG3328	transposase activity
O6U12_06935	COG0697	spore germination
O6U12_06940	COG0583	DNA-binding transcription factor activity
O6U12_06945	COG3739	integral membrane protein
O6U12_06960	COG2720	vancomycin resistance protein
O6U12_07000	COG2135	peptidase activity
O6U12_07010	COG3619	membrane
O6U12_07015	COG4305	rare lipoprotein A
O6U12_07020	COG2368	4-hydroxyphenylacetate
O6U12_07025	COG5278	phosphoserine phosphatase activity
O6U12_07025	COG0840	transmembrane signaling receptor activity
O6U12_07060	COG3328	transposase activity
O6U12_07075	COG0243	molybdopterin cofactor binding
O6U12_07080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O6U12_07085	COG1070	Carbohydrate kinase
O6U12_07090	COG2814	Major facilitator Superfamily
O6U12_07095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_07105	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
O6U12_07110	COG0300	oxidoreductase activity
O6U12_07120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_07125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O6U12_07130	COG0583	DNA-binding transcription factor activity
O6U12_07135	COG0067	glutamate synthase
O6U12_07135	COG0069	glutamate synthase activity
O6U12_07135	COG0070	glutamate synthase
O6U12_07140	COG0493	'glutamate synthase
O6U12_07145	COG0604	alcohol dehydrogenase
O6U12_07150	COG0583	DNA-binding transcription factor activity
O6U12_07155	COG0405	Gamma-glutamyltransferase
O6U12_07160	COG0166	Belongs to the GPI family
O6U12_07165	COG0582	viral genome integration into host DNA
O6U12_07175	COG3328	transposase activity
O6U12_07185	COG0534	Mate efflux family protein
O6U12_07190	COG2017	converts alpha-aldose to the beta-anomer
O6U12_07195	COG2027	D-alanyl-D-alanine carboxypeptidase
O6U12_07215	COG1649	PFAM Uncharacterised BCR, COG1649
O6U12_07230	COG1960	acyl-CoA dehydrogenase activity
O6U12_07235	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_07240	COG0439	Biotin carboxylase
O6U12_07245	COG0511	ligase activity, forming carbon-carbon bonds
O6U12_07250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O6U12_07255	COG1024	Enoyl-CoA hydratase
O6U12_07260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O6U12_07265	COG2404	hydrolase activity, acting on ester bonds
O6U12_07270	COG0586	Pfam SNARE associated Golgi protein
O6U12_07275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O6U12_07280	COG2246	polysaccharide biosynthetic process
O6U12_07285	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_07300	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
O6U12_07305	COG1115	amino acid carrier protein
O6U12_07320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O6U12_07325	COG0187	DNA topoisomerase II activity
O6U12_07330	COG1832	CoA-binding protein
O6U12_07335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O6U12_07340	COG4841	protein insertion into membrane
O6U12_07350	COG0824	Thioesterase
O6U12_07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_07375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O6U12_07390	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_07405	COG4846	Membrane protein involved in cytochrome C biogenesis
O6U12_07410	COG2201	protein-glutamate methylesterase activity
O6U12_07415	COG0785	Cytochrome C biogenesis protein
O6U12_07425	COG3763	UPF0154 protein
O6U12_07435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O6U12_07440	COG4224	UPF0291 protein
O6U12_07445	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O6U12_07450	COG1388	LysM domain
O6U12_07455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O6U12_07465	COG0346	lactoylglutathione lyase activity
O6U12_07475	COG4195	phage-related replication protein
O6U12_07505	COG0531	amino acid
O6U12_07510	COG0697	spore germination
O6U12_07525	COG3832	glyoxalase III activity
O6U12_07540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O6U12_07580	COG0756	dUTP diphosphatase activity
O6U12_07590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O6U12_07595	COG2814	Major facilitator Superfamily
O6U12_07600	COG1525	nuclease
O6U12_07615	COG1070	Carbohydrate kinase
O6U12_07620	COG2115	Belongs to the xylose isomerase family
O6U12_07625	COG1940	carbohydrate kinase activity
O6U12_07630	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_07635	COG2211	Major facilitator Superfamily
O6U12_07640	COG3328	transposase activity
O6U12_07645	COG0135	phosphoribosylanthranilate isomerase activity
O6U12_07670	COG3655	Transcriptional regulator
O6U12_07710	COG3328	transposase activity
O6U12_07720	COG4282	regulation of fungal-type cell wall biogenesis
O6U12_07745	COG5444	nuclease activity
O6U12_07755	COG1388	LysM domain
O6U12_07755	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_07755	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_07760	COG4824	toxin secretion phage lysis holin
O6U12_07780	COG5434	Belongs to the glycosyl hydrolase 28 family
O6U12_07785	COG1705	Flagellar rod assembly protein muramidase FlgJ
O6U12_07795	COG3953	SLT domain
O6U12_07795	COG5280	Phage tail tape measure protein TP901
O6U12_07900	COG0582	viral genome integration into host DNA
O6U12_07920	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_07945	COG3646	Phage regulatory protein
O6U12_07945	COG3645	SOS response
O6U12_07965	COG1396	sequence-specific DNA binding
O6U12_07980	COG0174	glutamine synthetase
O6U12_07985	COG0789	Transcriptional regulator
O6U12_07990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
O6U12_07995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O6U12_08000	COG0464	growth
O6U12_08005	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_08010	COG4112	unkown
O6U12_08015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O6U12_08020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O6U12_08025	COG1780	Probably involved in ribonucleotide reductase function
O6U12_08040	COG1923	regulation of RNA biosynthetic process
O6U12_08045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O6U12_08060	COG2076	Multidrug Resistance protein
O6U12_08065	COG2076	Multidrug Resistance protein
O6U12_08070	COG1764	response to oxidative stress
O6U12_08075	COG4195	phage-related replication protein
O6U12_08085	COG1404	Belongs to the peptidase S8 family
O6U12_08090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_08100	COG3226	Transcriptional regulator
O6U12_08115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O6U12_08120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O6U12_08130	COG4550	Control of competence regulator ComK, YlbF/YmcA
O6U12_08135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O6U12_08140	COG0156	8-amino-7-oxononanoate synthase activity
O6U12_08145	COG1063	alcohol dehydrogenase
O6U12_08150	COG2359	stage V sporulation protein S
O6U12_08155	COG1692	metallophosphoesterase
O6U12_08160	COG1418	mRNA catabolic process
O6U12_08165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O6U12_08170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O6U12_08175	COG1058	Belongs to the CinA family
O6U12_08175	COG1546	Belongs to the CinA family
O6U12_08180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O6U12_08185	COG1426	Protein conserved in bacteria
O6U12_08200	COG0300	oxidoreductase activity
O6U12_08205	COG0612	Peptidase, M16
O6U12_08210	COG0612	Peptidase, M16
O6U12_08215	COG2814	Major facilitator Superfamily
O6U12_08220	COG2188	Transcriptional regulator
O6U12_08225	COG1674	ftsk spoiiie
O6U12_08225	COG4980	gas vesicle protein
O6U12_08235	COG0740	serine-type endopeptidase activity
O6U12_08240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O6U12_08245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O6U12_08250	COG0527	aspartate kinase activity
O6U12_08255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O6U12_08260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O6U12_08265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O6U12_08270	COG1873	PFAM PRC-barrel domain
O6U12_08275	COG0612	Peptidase, M16
O6U12_08280	COG0726	polysaccharide deacetylase
O6U12_08285	COG1185	polyribonucleotide nucleotidyltransferase activity
O6U12_08290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O6U12_08295	COG0196	riboflavin kinase activity
O6U12_08300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O6U12_08305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O6U12_08310	COG1550	Protein conserved in bacteria
O6U12_08315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O6U12_08320	COG1358	cellular component organization or biogenesis
O6U12_08325	COG2740	Nucleic-acid-binding protein implicated in transcription termination
O6U12_08330	COG0195	Participates in both transcription termination and antitermination
O6U12_08335	COG0779	Required for maturation of 30S ribosomal subunits
O6U12_08340	COG2176	DNA-directed DNA polymerase activity
O6U12_08345	COG0442	prolyl-tRNA aminoacylation
O6U12_08350	COG0750	zinc metalloprotease
O6U12_08355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O6U12_08360	COG4589	Belongs to the CDS family
O6U12_08365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O6U12_08370	COG0233	cytoplasmic translational termination
O6U12_08375	COG0528	UMP kinase activity
O6U12_08380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O6U12_08385	COG0052	Belongs to the universal ribosomal protein uS2 family
O6U12_08395	COG1191	sigma factor activity
O6U12_08400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O6U12_08405	COG1776	CheC inhibitor of MCP methylation
O6U12_08410	COG0835	chemotaxis
O6U12_08415	COG0643	Histidine kinase
O6U12_08415	COG2198	Histidine kinase
O6U12_08420	COG2201	protein-glutamate methylesterase activity
O6U12_08425	COG0455	bacterial-type flagellum organization
O6U12_08430	COG1419	protein localization to endoplasmic reticulum
O6U12_08435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O6U12_08440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O6U12_08445	COG1684	flagellar biosynthetic protein fliR
O6U12_08450	COG1987	bacterial-type flagellum assembly
O6U12_08455	COG1338	Plays a role in the flagellum-specific transport system
O6U12_08460	COG3190	flagellar
O6U12_08465	COG2201	protein-glutamate methylesterase activity
O6U12_08470	COG1776	CheC inhibitor of MCP methylation
O6U12_08470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O6U12_08475	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O6U12_08480	COG1580	Controls the rotational direction of flagella during chemotaxis
O6U12_08485	COG1582	Flagellar protein (FlbD)
O6U12_08490	COG4786	Flagellar basal body rod
O6U12_08495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O6U12_08500	COG3144	bacterial-type flagellum assembly
O6U12_08505	COG3334	PFAM MgtE intracellular
O6U12_08510	COG2882	bacterial-type flagellum organization
O6U12_08515	COG1157	protein secretion by the type III secretion system
O6U12_08520	COG1317	bacterial-type flagellum organization
O6U12_08525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O6U12_08530	COG1766	The M ring may be actively involved in energy transduction
O6U12_08535	COG1677	Flagellar hook-basal body complex protein FliE
O6U12_08540	COG1558	bacterial-type flagellum-dependent cell motility
O6U12_08545	COG1815	bacterial-type flagellum-dependent cell motility
O6U12_08550	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O6U12_08555	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O6U12_08560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O6U12_08565	COG4974	Belongs to the 'phage' integrase family
O6U12_08570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
O6U12_08575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O6U12_08580	COG0758	DNA mediated transformation
O6U12_08585	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O6U12_08590	COG0045	succinate-CoA ligase (ADP-forming) activity
O6U12_08595	COG2257	FlhB HrpN YscU SpaS Family
O6U12_08605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O6U12_08610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O6U12_08615	COG0335	large ribosomal subunit rRNA binding
O6U12_08620	COG0336	Belongs to the RNA methyltransferase TrmD family
O6U12_08625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O6U12_08635	COG1837	Belongs to the UPF0109 family
O6U12_08640	COG0228	four-way junction DNA binding
O6U12_08645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O6U12_08650	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
O6U12_08660	COG0552	protein localization to endoplasmic reticulum
O6U12_08665	COG1196	nuclear chromosome segregation
O6U12_08670	COG0571	ribonuclease III activity
O6U12_08680	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_08685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O6U12_08690	COG0416	fatty acid biosynthetic process
O6U12_08695	COG2050	protein possibly involved in aromatic compounds catabolism
O6U12_08695	COG1349	DNA-binding transcription factor activity
O6U12_08700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O6U12_08705	COG1760	l-serine dehydratase
O6U12_08710	COG1760	l-serine dehydratase
O6U12_08715	COG1461	Dihydroxyacetone kinase
O6U12_08720	COG1302	Protein conserved in bacteria
O6U12_08725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O6U12_08735	COG1564	THIamine pyrophosphokinase
O6U12_08740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O6U12_08745	COG1162	GTPase activity
O6U12_08750	COG0515	serine threonine protein kinase
O6U12_08750	COG2815	serine threonine protein kinase
O6U12_08755	COG0631	protein serine/threonine phosphatase activity
O6U12_08760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O6U12_08765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O6U12_08765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O6U12_08770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O6U12_08775	COG0242	peptide deformylase activity
O6U12_08780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O6U12_08785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O6U12_08790	COG1758	RNA polymerase activity
O6U12_08795	COG0194	GDP metabolic process
O6U12_08805	COG1561	YicC-like family, N-terminal region
O6U12_08810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O6U12_08815	COG1293	RNA-binding protein homologous to eukaryotic snRNP
O6U12_08820	COG1648	precorrin-2 dehydrogenase activity
O6U12_08825	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
O6U12_08830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O6U12_08835	COG0529	Catalyzes the synthesis of activated sulfate
O6U12_08840	COG2046	Belongs to the sulfate adenylyltransferase family
O6U12_08845	COG0306	phosphate transporter
O6U12_08850	COG0175	sulfate reduction
O6U12_08855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O6U12_08860	COG0284	orotidine-5'-phosphate decarboxylase activity
O6U12_08865	COG0167	dihydroorotate dehydrogenase activity
O6U12_08870	COG0543	2 iron, 2 sulfur cluster binding
O6U12_08875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O6U12_08880	COG0505	Belongs to the CarA family
O6U12_08885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O6U12_08890	COG0540	Belongs to the ATCase OTCase family
O6U12_08895	COG2233	PERMEase
O6U12_08900	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O6U12_08905	COG0564	pseudouridine synthase activity
O6U12_08910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O6U12_08915	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O6U12_08920	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O6U12_08925	COG3599	regulation of cell shape
O6U12_08930	COG2302	S4 RNA-binding domain
O6U12_08935	COG0762	integral membrane protein
O6U12_08940	COG1799	cell septum assembly
O6U12_08945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O6U12_08950	COG1496	oxidoreductase activity
O6U12_08955	COG1873	PFAM PRC-barrel domain
O6U12_08960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O6U12_08965	COG1119	ATPase activity
O6U12_08970	COG1191	sigma factor activity
O6U12_08975	COG1191	sigma factor activity
O6U12_08985	COG1404	Belongs to the peptidase S8 family
O6U12_08985	COG4412	M6 family metalloprotease domain protein
O6U12_08990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O6U12_08995	COG0849	cell division
O6U12_09000	COG3856	small basic protein
O6U12_09005	COG3879	Bacterial protein of unknown function (DUF881)
O6U12_09010	COG3879	Bacterial protein of unknown function (DUF881)
O6U12_09015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O6U12_09020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O6U12_09025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O6U12_09030	COG0772	Belongs to the SEDS family
O6U12_09035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O6U12_09040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O6U12_09045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O6U12_09050	COG0768	penicillin binding
O6U12_09055	COG0768	penicillin binding
O6U12_09060	COG4839	cell division protein FtsL
O6U12_09065	COG0275	rRNA processing
O6U12_09070	COG2001	Belongs to the MraZ family
O6U12_09075	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
O6U12_09080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O6U12_09085	COG0454	-acetyltransferase
O6U12_09100	COG1399	metal-binding, possibly nucleic acid-binding protein
O6U12_09110	COG1323	Belongs to the UPF0348 family
O6U12_09115	COG3480	Lon protease (S16) C-terminal proteolytic domain
O6U12_09120	COG1752	Esterase of the alpha-beta hydrolase superfamily
O6U12_09125	COG3314	Sporulation integral membrane protein YlbJ
O6U12_09130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O6U12_09135	COG0742	ribosomal rna small subunit methyltransferase
O6U12_09140	COG4471	UPF0298 protein
O6U12_09145	COG3679	Belongs to the UPF0342 family
O6U12_09160	COG2340	Cysteine-rich secretory protein family
O6U12_09165	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
O6U12_09175	COG3336	cytochrome c oxidase
O6U12_09180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O6U12_09185	COG1845	cytochrome c oxidase, subunit III
O6U12_09190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O6U12_09195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O6U12_09195	COG2010	Cytochrome c
O6U12_09200	COG0109	protoheme IX farnesyltransferase activity
O6U12_09205	COG1612	heme a metabolic process
O6U12_09210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O6U12_09215	COG0772	Belongs to the SEDS family
O6U12_09220	COG4838	Belongs to the UPF0358 family
O6U12_09225	COG2066	Belongs to the glutaminase family
O6U12_09230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O6U12_09235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O6U12_09245	COG4896	Protein conserved in bacteria
O6U12_09255	COG1217	gtp-binding protein TYPA
O6U12_09275	COG1595	DNA-templated transcription, initiation
O6U12_09295	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
O6U12_09305	COG0483	inositol monophosphate 1-phosphatase activity
O6U12_09315	COG4493	Belongs to the UPF0637 family
O6U12_09320	COG4476	Belongs to the UPF0223 family
O6U12_09325	COG1982	Orn Lys Arg decarboxylase major
O6U12_09340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_09345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O6U12_09350	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_09355	COG0022	dehydrogenase e1 component
O6U12_09360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O6U12_09365	COG0497	DNA recombination
O6U12_09375	COG0242	peptide deformylase activity
O6U12_09380	COG0561	phosphatase activity
O6U12_09385	COG5503	Protein of unknown function (DUF1447)
O6U12_09390	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O6U12_09395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O6U12_09400	COG0569	domain protein
O6U12_09405	COG2105	PFAM AIG2 family protein
O6U12_09405	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
O6U12_09410	COG3852	Histidine kinase
O6U12_09415	COG2002	toxin-antitoxin pair type II binding
O6U12_09420	COG1077	Cell shape determining protein MreB Mrl
O6U12_09430	COG2309	aminopeptidase activity
O6U12_09435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O6U12_09440	COG0488	(ABC) transporter
O6U12_09450	COG0681	Belongs to the peptidase S26 family
O6U12_09455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_09455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_09455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_09460	COG1105	Belongs to the carbohydrate kinase PfkB family
O6U12_09465	COG1349	DNA-binding transcription factor activity
O6U12_09470	COG0577	efflux transmembrane transporter activity
O6U12_09475	COG1136	(ABC) transporter
O6U12_09480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O6U12_09490	COG1132	(ABC) transporter
O6U12_09495	COG1132	(ABC) transporter
O6U12_09500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O6U12_09505	COG0314	molybdopterin synthase activity
O6U12_09510	COG1763	Mo-molybdopterin cofactor biosynthetic process
O6U12_09515	COG0303	'Molybdopterin
O6U12_09520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O6U12_09525	COG0746	molybdenum cofactor guanylyltransferase activity
O6U12_09545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_09550	COG0450	alkyl hydroperoxide reductase
O6U12_09555	COG0668	transmembrane transport
O6U12_09565	COG1473	amidohydrolase
O6U12_09570	COG2171	N-acyltransferase activity
O6U12_09575	COG0716	FMN binding
O6U12_09585	COG0716	FMN binding
O6U12_09590	COG0583	DNA-binding transcription factor activity
O6U12_09595	COG0517	IMP dehydrogenase activity
O6U12_09605	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
O6U12_09610	COG4703	Protein of unknown function (DUF1797)
O6U12_09615	COG2200	EAL domain
O6U12_09625	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_09635	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_09640	COG1408	metallophosphoesterase
O6U12_09645	COG1376	ErfK ybiS ycfS ynhG family protein
O6U12_09650	COG2814	Major facilitator Superfamily
O6U12_09660	COG0784	Response regulator, receiver
O6U12_09660	COG0835	chemotaxis
O6U12_09670	COG0436	Aminotransferase
O6U12_09675	COG4191	Histidine kinase
O6U12_09680	COG0768	penicillin binding
O6U12_09685	COG2340	Cysteine-rich secretory protein family
O6U12_09690	COG3328	transposase activity
O6U12_09695	COG2084	Dehydrogenase
O6U12_09700	COG0840	transmembrane signaling receptor activity
O6U12_09705	COG0456	acetyltransferase
O6U12_09710	COG1533	DNA photolyase activity
O6U12_09720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O6U12_09725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_09730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_09730	COG2190	(PTS) system
O6U12_09730	COG1263	PTS System
O6U12_09735	COG3711	transcriptional antiterminator
O6U12_09740	COG1609	Transcriptional regulator
O6U12_09745	COG0006	proline dipeptidase activity
O6U12_09755	COG2217	Heavy metal translocating P-type atpase
O6U12_09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_09765	COG2244	polysaccharide biosynthetic process
O6U12_09770	COG3773	Cell wall hydrolase
O6U12_09780	COG4873	Protein conserved in bacteria
O6U12_09790	COG3858	chitin binding
O6U12_09795	COG1388	LysM domain
O6U12_09800	COG4641	Protein conserved in bacteria
O6U12_09800	COG1388	LysM domain
O6U12_09805	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_09810	COG1733	regulation of RNA biosynthetic process
O6U12_09815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O6U12_09820	COG0602	queuosine metabolic process
O6U12_09825	COG0720	synthase
O6U12_09830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O6U12_09835	COG3949	Membrane
O6U12_09840	COG0542	response to heat
O6U12_09845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O6U12_09850	COG1360	Flagellar Motor Protein
O6U12_09855	COG1846	Transcriptional regulator
O6U12_09860	COG3852	Histidine kinase
O6U12_09875	COG3339	Conserved Protein
O6U12_09880	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O6U12_09885	COG0235	Class ii aldolase
O6U12_09890	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
O6U12_09895	COG1850	ribulose-bisphosphate carboxylase activity
O6U12_09900	COG0436	Aminotransferase
O6U12_09905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O6U12_09910	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
O6U12_09915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O6U12_09925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O6U12_09930	COG5002	protein histidine kinase activity
O6U12_09935	COG3594	Acyltransferase
O6U12_09950	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O6U12_09955	COG0501	Belongs to the peptidase M48B family
O6U12_09975	COG1191	sigma factor activity
O6U12_09980	COG0861	Integral membrane protein TerC family
O6U12_09985	COG0586	Pfam SNARE associated Golgi protein
O6U12_09995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O6U12_10000	COG3285	dna ligase
O6U12_10000	COG1793	dna ligase
O6U12_10005	COG0463	Glycosyl transferase, family 2
O6U12_10015	COG1408	metallophosphoesterase
O6U12_10020	COG0726	polysaccharide deacetylase
O6U12_10025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O6U12_10030	COG1846	Transcriptional regulator
O6U12_10045	COG0789	Transcriptional regulator
O6U12_10050	COG2239	Acts as a magnesium transporter
O6U12_10065	COG3212	peptidase
O6U12_10070	COG3212	peptidase
O6U12_10075	COG5002	protein histidine kinase activity
O6U12_10075	COG3850	Histidine kinase
O6U12_10080	COG0745	RESPONSE REGULATOR receiver
O6U12_10090	COG4721	ABC-type cobalt transport system, permease component
O6U12_10095	COG1122	ATPase activity
O6U12_10100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O6U12_10105	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_10110	COG1404	Belongs to the peptidase S8 family
O6U12_10115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O6U12_10125	COG0590	tRNA wobble adenosine to inosine editing
O6U12_10135	COG1764	response to oxidative stress
O6U12_10140	COG1846	Transcriptional regulator
O6U12_10145	COG1764	response to oxidative stress
O6U12_10150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O6U12_10155	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O6U12_10160	COG0788	formyltetrahydrofolate deformylase activity
O6U12_10165	COG2076	Multidrug Resistance protein
O6U12_10170	COG2076	Multidrug Resistance protein
O6U12_10175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_10180	COG2318	DinB family
O6U12_10185	COG2323	membrane
O6U12_10195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O6U12_10195	COG1017	nitric oxide dioxygenase activity
O6U12_10200	COG1607	acyl-coa hydrolase
O6U12_10210	COG2706	6-phosphogluconolactonase activity
O6U12_10215	COG4608	Belongs to the ABC transporter superfamily
O6U12_10220	COG0791	NLP P60 protein
O6U12_10225	COG4948	Mandelate Racemase Muconate Lactonizing
O6U12_10230	COG1619	proteins homologs of microcin C7 resistance protein MccF
O6U12_10235	COG4166	transmembrane transport
O6U12_10240	COG0444	Belongs to the ABC transporter superfamily
O6U12_10245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O6U12_10250	COG0601	transmembrane transport
O6U12_10255	COG2362	D-Aminopeptidase
O6U12_10260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O6U12_10265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_10275	COG0463	Glycosyl transferase, family 2
O6U12_10280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O6U12_10290	COG0346	lactoylglutathione lyase activity
O6U12_10295	COG0531	amino acid
O6U12_10300	COG1392	Phosphate transport regulator
O6U12_10305	COG0306	phosphate transporter
O6U12_10325	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_10325	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_10365	COG3778	Protein conserved in bacteria
O6U12_10370	COG3299	homolog of phage Mu protein gp47
O6U12_10375	COG3628	GPW Gp25 family protein
O6U12_10385	COG4193	domain, Protein
O6U12_10390	COG1652	LysM domain
O6U12_10395	COG5412	phage tail tape measure protein
O6U12_10395	COG3953	SLT domain
O6U12_10445	COG4653	Phage capsid family
O6U12_10450	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O6U12_10455	COG5518	Phage portal protein
O6U12_10460	COG1783	phage Terminase large subunit
O6U12_10465	COG5484	DNA packaging
O6U12_10465	COG3728	DNA packaging
O6U12_10470	COG1595	DNA-templated transcription, initiation
O6U12_10505	COG1396	sequence-specific DNA binding
O6U12_10510	COG2856	Zn peptidase
O6U12_10515	COG3546	catalase activity
O6U12_10520	COG4195	phage-related replication protein
O6U12_10530	COG1388	LysM domain
O6U12_10530	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_10530	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_10535	COG2350	Protein conserved in bacteria
O6U12_10545	COG0457	Tetratricopeptide repeat
O6U12_10550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O6U12_10555	COG2318	DinB family
O6U12_10560	COG0730	response to heat
O6U12_10565	COG2721	sulfolactate sulfo-lyase activity
O6U12_10570	COG0246	Mannitol dehydrogenase
O6U12_10575	COG1609	Transcriptional regulator
O6U12_10580	COG2271	Major facilitator Superfamily
O6U12_10585	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_10590	COG1312	Catalyzes the dehydration of D-mannonate
O6U12_10595	COG1063	alcohol dehydrogenase
O6U12_10600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
O6U12_10605	COG2211	Major facilitator Superfamily
O6U12_10610	COG1904	glucuronate isomerase
O6U12_10615	COG1252	NADH dehydrogenase
O6U12_10625	COG4297	protein containing double-stranded beta helix domain
O6U12_10630	COG0697	spore germination
O6U12_10635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O6U12_10640	COG0390	transport system, permease component
O6U12_10645	COG1587	Uroporphyrinogen-III synthase
O6U12_10655	COG1819	glycosyl
O6U12_10660	COG2124	cytochrome p450
O6U12_10680	COG2427	Protein of unknown function (DUF1641)
O6U12_10695	COG2205	protein histidine kinase activity
O6U12_10700	COG5504	Zn-dependent protease
O6U12_10715	COG0726	polysaccharide deacetylase
O6U12_10725	COG0109	protoheme IX farnesyltransferase activity
O6U12_10740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O6U12_10750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_10755	COG3328	transposase activity
O6U12_10765	COG1482	cell wall glycoprotein biosynthetic process
O6U12_10770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_10770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_10770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O6U12_10775	COG3711	transcriptional antiterminator
O6U12_10775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_10785	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_10790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O6U12_10845	COG5444	nuclease activity
O6U12_10870	COG5505	Protein of unknown function (DUF819)
O6U12_10875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_10880	COG0626	cystathionine gamma-synthase activity
O6U12_10885	COG0626	cystathionine gamma-synthase activity
O6U12_10890	COG2382	esterase
O6U12_10895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O6U12_10900	COG2153	protein acetylation
O6U12_10910	COG0210	DNA helicase
O6U12_10965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O6U12_10970	COG0351	phosphomethylpyrimidine kinase
O6U12_10975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O6U12_10980	COG2022	thiamine diphosphate biosynthetic process
O6U12_10985	COG2104	thiamine diphosphate biosynthetic process
O6U12_10990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O6U12_10995	COG0352	thiamine-phosphate diphosphorylase activity
O6U12_11000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O6U12_11005	COG0569	domain protein
O6U12_11005	COG0475	glutathione-regulated potassium exporter activity
O6U12_11010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O6U12_11015	COG0564	pseudouridine synthase activity
O6U12_11020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O6U12_11025	COG2357	RelA SpoT domain protein
O6U12_11035	COG4116	CYTH
O6U12_11040	COG0741	lytic transglycosylase activity
O6U12_11045	COG2346	COG2346, Truncated hemoglobins
O6U12_11050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O6U12_11060	COG1164	Oligoendopeptidase f
O6U12_11065	COG4469	Competence protein
O6U12_11075	COG4862	establishment of competence for transformation
O6U12_11085	COG0861	Integral membrane protein TerC family
O6U12_11090	COG1393	Belongs to the ArsC family
O6U12_11095	COG0456	acetyltransferase
O6U12_11100	COG2814	Major facilitator Superfamily
O6U12_11105	COG4608	Belongs to the ABC transporter superfamily
O6U12_11110	COG0444	Belongs to the ABC transporter superfamily
O6U12_11115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O6U12_11120	COG0601	transmembrane transport
O6U12_11125	COG4166	transmembrane transport
O6U12_11130	COG0180	Tryptophanyl-tRNA synthetase
O6U12_11140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O6U12_11145	COG0601	transmembrane transport
O6U12_11155	COG4608	Belongs to the ABC transporter superfamily
O6U12_11160	COG0444	Belongs to the ABC transporter superfamily
O6U12_11165	COG5504	Zn-dependent protease
O6U12_11170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O6U12_11175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_11190	COG1744	ABC transporter substrate-binding protein PnrA-like
O6U12_11200	COG2267	carboxylic ester hydrolase activity
O6U12_11215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O6U12_11220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O6U12_11225	COG0505	Belongs to the CarA family
O6U12_11230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O6U12_11240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O6U12_11245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O6U12_11250	COG2271	Major facilitator Superfamily
O6U12_11255	COG0277	FAD linked oxidase domain protein
O6U12_11265	COG2151	metal-sulfur cluster biosynthetic enzyme
O6U12_11270	COG1073	alpha beta
O6U12_11275	COG0561	phosphatase activity
O6U12_11295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_11300	COG1307	EDD domain protein, DegV family
O6U12_11305	COG3227	Zinc metalloprotease (Elastase)
O6U12_11320	COG1695	Transcriptional regulator
O6U12_11345	COG1666	GTP binding
O6U12_11350	COG0646	methionine synthase
O6U12_11350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O6U12_11355	COG2153	protein acetylation
O6U12_11360	COG0454	-acetyltransferase
O6U12_11365	COG2814	Major facilitator Superfamily
O6U12_11370	COG2323	membrane
O6U12_11375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_11385	COG2323	membrane
O6U12_11400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_11455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_11460	COG1809	phosphosulfolactate synthase activity
O6U12_11465	COG2045	Belongs to the ComB family
O6U12_11480	COG0529	Catalyzes the synthesis of activated sulfate
O6U12_11485	COG2267	carboxylic ester hydrolase activity
O6U12_11490	COG1357	PFAM Pentapeptide repeats (8 copies)
O6U12_11495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_11500	COG1279	arginine transmembrane transporter activity
O6U12_11505	COG2318	DinB family
O6U12_11510	COG0673	inositol 2-dehydrogenase activity
O6U12_11515	COG1609	Transcriptional regulator
O6U12_11520	COG1917	Cupin 2, conserved barrel domain protein
O6U12_11520	COG2207	Transcriptional regulator
O6U12_11525	COG0534	Mate efflux family protein
O6U12_11535	COG0367	asparagine synthase
O6U12_11545	COG1404	Belongs to the peptidase S8 family
O6U12_11555	COG0179	Fumarylacetoacetate (FAA) hydrolase
O6U12_11560	COG5337	Spore coat protein CotH
O6U12_11600	COG1403	HNH endonuclease
O6U12_11605	COG0419	ATPase involved in DNA repair
O6U12_11610	COG0420	3'-5' exonuclease activity
O6U12_11615	COG1074	ATP-dependent DNA helicase activity
O6U12_11620	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
O6U12_11625	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
O6U12_11635	COG4533	DNA binding
O6U12_11640	COG2814	Major facilitator Superfamily
O6U12_11640	COG0477	Major facilitator Superfamily
O6U12_11645	COG3180	Ammonia monooxygenase
O6U12_11650	COG1609	Transcriptional regulator
O6U12_11660	COG0561	phosphatase activity
O6U12_11665	COG0673	inositol 2-dehydrogenase activity
O6U12_11670	COG0738	Major facilitator superfamily
O6U12_11675	COG1846	Transcriptional regulator
O6U12_11680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O6U12_11685	COG0681	Belongs to the peptidase S26 family
O6U12_11690	COG0398	Pfam SNARE associated Golgi protein
O6U12_11705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_11715	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_11720	COG4903	ComK protein
O6U12_11730	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_11740	COG0840	transmembrane signaling receptor activity
O6U12_11745	COG1268	BioY protein
O6U12_11750	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_11755	COG0183	Belongs to the thiolase family
O6U12_11760	COG0406	alpha-ribazole phosphatase activity
O6U12_11765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
O6U12_11770	COG0604	alcohol dehydrogenase
O6U12_11775	COG0456	acetyltransferase
O6U12_11780	COG1404	Belongs to the peptidase S8 family
O6U12_11785	COG0501	Belongs to the peptidase M48B family
O6U12_11795	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_11800	COG0702	epimerase
O6U12_11805	COG0095	Lipoate-protein ligase
O6U12_11810	COG1234	tRNA 3'-trailer cleavage
O6U12_11820	COG1301	dicarboxylic acid transport
O6U12_11825	COG4405	Protein conserved in bacteria
O6U12_11830	COG1363	Peptidase, m42
O6U12_11840	COG4377	Putative membrane peptidase family (DUF2324)
O6U12_11845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_11850	COG1511	domain protein
O6U12_11855	COG1309	transcriptional regulator
O6U12_11860	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O6U12_11865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O6U12_11870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O6U12_11875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_11880	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_11890	COG3069	C4-dicarboxylate transmembrane transporter activity
O6U12_11895	COG1473	amidohydrolase
O6U12_11905	COG4473	ABC transporter
O6U12_11910	COG1131	(ABC) transporter
O6U12_11915	COG0537	adenosine 5'-monophosphoramidase activity
O6U12_11920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O6U12_11935	COG4980	gas vesicle protein
O6U12_11940	COG1846	Transcriptional regulator
O6U12_11970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O6U12_11980	COG3481	metal-dependent phosphohydrolase, HD sub domain
O6U12_11985	COG4717	serine-type aminopeptidase activity
O6U12_11990	COG0420	3'-5' exonuclease activity
O6U12_11995	COG1668	transmembrane transport
O6U12_12000	COG4152	abc transporter atp-binding protein
O6U12_12010	COG1024	Enoyl-CoA hydratase
O6U12_12020	COG0490	domain, Protein
O6U12_12025	COG0475	glutathione-regulated potassium exporter activity
O6U12_12030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O6U12_12035	COG0561	phosphatase activity
O6U12_12040	COG4335	DNA alkylation repair
O6U12_12045	COG3679	Belongs to the UPF0342 family
O6U12_12050	COG4399	Belongs to the UPF0754 family
O6U12_12055	COG0189	ligase activity
O6U12_12060	COG0189	ligase activity
O6U12_12085	COG1132	(ABC) transporter
O6U12_12090	COG1132	(ABC) transporter
O6U12_12100	COG0589	response to stress
O6U12_12105	COG1757	Na H antiporter
O6U12_12110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_12115	COG0726	polysaccharide deacetylase
O6U12_12120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O6U12_12125	COG0668	transmembrane transport
O6U12_12135	COG0584	glycerophosphoryl diester phosphodiesterase
O6U12_12140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O6U12_12145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O6U12_12150	COG1253	flavin adenine dinucleotide binding
O6U12_12155	COG0436	Aminotransferase
O6U12_12160	COG0789	Transcriptional regulator
O6U12_12165	COG1253	flavin adenine dinucleotide binding
O6U12_12170	COG0204	Acyl-transferase
O6U12_12175	COG0667	Aldo Keto reductase
O6U12_12180	COG1595	DNA-templated transcription, initiation
O6U12_12195	COG0456	acetyltransferase
O6U12_12200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_12205	COG0733	neurotransmitter:sodium symporter activity
O6U12_12210	COG0531	amino acid
O6U12_12215	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_12220	COG0372	Belongs to the citrate synthase family
O6U12_12230	COG0791	NLP P60 protein
O6U12_12230	COG1388	LysM domain
O6U12_12235	COG1785	Belongs to the alkaline phosphatase family
O6U12_12240	COG2719	SpoVR family
O6U12_12250	COG1959	2 iron, 2 sulfur cluster binding
O6U12_12255	COG0791	NLP P60 protein
O6U12_12255	COG1388	LysM domain
O6U12_12270	COG0431	NADPH-dependent FMN reductase
O6U12_12275	COG2197	response regulator
O6U12_12280	COG2203	Gaf domain
O6U12_12280	COG4585	Histidine kinase
O6U12_12285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O6U12_12290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O6U12_12295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O6U12_12300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O6U12_12305	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
O6U12_12310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O6U12_12315	COG3153	acetyltransferase
O6U12_12315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O6U12_12320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O6U12_12325	COG0517	IMP dehydrogenase activity
O6U12_12335	COG0564	pseudouridine synthase activity
O6U12_12340	COG3764	Sortase (surface protein transpeptidase)
O6U12_12345	COG0737	Belongs to the 5'-nucleotidase family
O6U12_12345	COG1525	nuclease
O6U12_12345	COG4085	toxin activity
O6U12_12365	COG1823	symporter activity
O6U12_12375	COG1464	Belongs to the NlpA lipoprotein family
O6U12_12380	COG1278	Cold shock
O6U12_12385	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O6U12_12390	COG1131	(ABC) transporter
O6U12_12395	COG1131	(ABC) transporter
O6U12_12400	COG1725	Transcriptional regulator
O6U12_12420	COG0655	NAD(P)H dehydrogenase (quinone) activity
O6U12_12425	COG2814	Major facilitator Superfamily
O6U12_12430	COG1566	PFAM secretion protein HlyD family protein
O6U12_12435	COG1846	Transcriptional regulator
O6U12_12440	COG2718	Belongs to the UPF0229 family
O6U12_12445	COG2766	serine protein kinase
O6U12_12450	COG1664	Polymer-forming cytoskeletal
O6U12_12455	COG0789	Transcriptional regulator
O6U12_12465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O6U12_12475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O6U12_12480	COG3382	B3 4 domain protein
O6U12_12490	COG1476	TRANSCRIPTIONal
O6U12_12500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O6U12_12510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_12515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O6U12_12520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O6U12_12525	COG1116	anion transmembrane transporter activity
O6U12_12530	COG0753	catalase activity
O6U12_12540	COG0277	FAD linked oxidase domain protein
O6U12_12545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O6U12_12550	COG3340	Belongs to the peptidase S51 family
O6U12_12555	COG5577	PFAM Coat F domain
O6U12_12565	COG4326	sporulation control protein
O6U12_12680	COG0735	belongs to the Fur family
O6U12_12685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O6U12_12690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O6U12_12695	COG4129	membrane
O6U12_12700	COG1132	(ABC) transporter
O6U12_12705	COG3557	Belongs to the UPF0374 family
O6U12_12720	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_12730	COG1194	a g-specific adenine glycosylase
O6U12_12735	COG1988	membrane-bound metal-dependent
O6U12_12740	COG4485	Bacterial membrane protein, YfhO
O6U12_12745	COG0463	Glycosyl transferase, family 2
O6U12_12750	COG0596	Alpha beta hydrolase
O6U12_12755	COG5658	integral membrane protein
O6U12_12760	COG3103	Sh3 type 3 domain protein
O6U12_12780	COG2814	Major facilitator Superfamily
O6U12_12790	COG2137	regulation of response to DNA damage stimulus
O6U12_12815	COG0778	Nitroreductase
O6U12_12820	COG0384	phenazine biosynthesis protein PhzF
O6U12_12825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_12830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_12835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_12840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O6U12_12840	COG0392	lysyltransferase activity
O6U12_12845	COG1846	Transcriptional regulator
O6U12_12850	COG2814	Major facilitator Superfamily
O6U12_12855	COG2318	DinB family
O6U12_12860	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
O6U12_12870	COG1695	Transcriptional regulator
O6U12_12880	COG0842	Transport permease protein
O6U12_12885	COG0842	Transport permease protein
O6U12_12885	COG1511	domain protein
O6U12_12890	COG1131	(ABC) transporter
O6U12_12895	COG2197	response regulator
O6U12_12900	COG4585	Histidine kinase
O6U12_12905	COG0673	inositol 2-dehydrogenase activity
O6U12_12910	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_12915	COG2814	Major facilitator Superfamily
O6U12_12920	COG1917	Cupin 2, conserved barrel domain protein
O6U12_12920	COG4977	sequence-specific DNA binding
O6U12_12925	COG2514	catechol 2,3-dioxygenase activity
O6U12_12930	COG2259	Doxx family
O6U12_12935	COG1132	(ABC) transporter
O6U12_12940	COG1132	(ABC) transporter
O6U12_12945	COG1263	PTS System
O6U12_12945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_12950	COG1737	Transcriptional regulator
O6U12_12955	COG1486	melibiose metabolic process
O6U12_12960	COG4842	Belongs to the WXG100 family
O6U12_12980	COG1742	UPF0060 membrane protein
O6U12_12990	COG3284	Transcriptional regulator
O6U12_12995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O6U12_13000	COG0508	dehydrogenase complex catalyzes the overall conversion of
O6U12_13005	COG0022	dehydrogenase e1 component
O6U12_13010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O6U12_13020	COG4637	Psort location Cytoplasmic, score
O6U12_13025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O6U12_13035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O6U12_13040	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O6U12_13045	COG0598	Magnesium transport protein CorA
O6U12_13050	COG2084	Dehydrogenase
O6U12_13055	COG0726	polysaccharide deacetylase
O6U12_13065	COG0535	radical SAM domain protein
O6U12_13070	COG0668	transmembrane transport
O6U12_13085	COG0387	Pfam Sodium calcium exchanger
O6U12_13090	COG0477	Major facilitator Superfamily
O6U12_13095	COG1295	ribonuclease BN
O6U12_13100	COG4980	gas vesicle protein
O6U12_13105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O6U12_13110	COG4840	Belongs to the UPF0435 family
O6U12_13115	COG2814	Major facilitator Superfamily
O6U12_13120	COG0693	protein deglycase activity
O6U12_13125	COG0737	Belongs to the 5'-nucleotidase family
O6U12_13130	COG0778	Nitroreductase
O6U12_13135	COG2188	Transcriptional regulator
O6U12_13140	COG0366	Alpha amylase catalytic
O6U12_13145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_13145	COG1263	PTS System
O6U12_13170	COG1368	sulfuric ester hydrolase activity
O6U12_13175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_13175	COG1263	PTS System
O6U12_13180	COG0024	Methionine aminopeptidase
O6U12_13205	COG1254	Belongs to the acylphosphatase family
O6U12_13210	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
O6U12_13215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_13220	COG2851	Citrate transporter
O6U12_13225	COG3181	Tripartite tricarboxylate transporter family receptor
O6U12_13230	COG4565	transcriptional regulatory protein
O6U12_13235	COG3290	protein histidine kinase activity
O6U12_13240	COG0471	metal ion transport
O6U12_13245	COG3866	Pectate lyase
O6U12_13255	COG0513	Belongs to the DEAD box helicase family
O6U12_13260	COG0488	(ABC) transporter
O6U12_13285	COG2814	Major facilitator Superfamily
O6U12_13290	COG0789	Transcriptional regulator
O6U12_13300	COG0488	(ABC) transporter
O6U12_13310	COG0840	transmembrane signaling receptor activity
O6U12_13315	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_13320	COG0531	amino acid
O6U12_13325	COG1011	Hydrolase
O6U12_13330	COG2223	nitrite transmembrane transporter activity
O6U12_13335	COG1442	glycosyl transferase family 8
O6U12_13340	COG1216	Glycosyl transferase, family 2
O6U12_13345	COG1442	glycosyl transferase family 8
O6U12_13350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O6U12_13355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O6U12_13360	COG1368	sulfuric ester hydrolase activity
O6U12_13365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O6U12_13365	COG2124	cytochrome p450
O6U12_13380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O6U12_13385	COG1846	Transcriptional regulator
O6U12_13390	COG0697	spore germination
O6U12_13395	COG0670	Belongs to the BI1 family
O6U12_13400	COG5583	Uncharacterized small protein (DUF2292)
O6U12_13420	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_13430	COG2323	membrane
O6U12_13435	COG1486	melibiose metabolic process
O6U12_13440	COG0395	ABC-type sugar transport system, permease component
O6U12_13445	COG4209	transmembrane transport
O6U12_13450	COG1653	transport
O6U12_13460	COG1874	Beta-galactosidase
O6U12_13465	COG2755	lipolytic protein G-D-S-L family
O6U12_13470	COG3401	FG-GAP repeat protein
O6U12_13480	COG5578	integral membrane protein
O6U12_13490	COG2755	lipolytic protein G-D-S-L family
O6U12_13500	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
O6U12_13505	COG0395	ABC-type sugar transport system, permease component
O6U12_13510	COG1175	transmembrane transport
O6U12_13515	COG1653	transport
O6U12_13520	COG2207	Transcriptional regulator
O6U12_13520	COG4753	response regulator
O6U12_13525	COG2972	Histidine kinase
O6U12_13530	COG5578	integral membrane protein
O6U12_13540	COG0454	-acetyltransferase
O6U12_13545	COG3546	catalase activity
O6U12_13560	COG1309	transcriptional regulator
O6U12_13570	COG0217	transcriptional regulatory protein
O6U12_13580	COG0457	Tetratricopeptide repeat
O6U12_13590	COG5444	nuclease activity
O6U12_13610	COG0457	Tetratricopeptide repeat
O6U12_13620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O6U12_13625	COG1597	lipid kinase activity
O6U12_13630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O6U12_13640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O6U12_13645	COG0154	amidase activity
O6U12_13650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O6U12_13655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_13660	COG1285	pathogenesis
O6U12_13665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O6U12_13670	COG4851	CamS sex pheromone cAM373 precursor
O6U12_13675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O6U12_13680	COG0210	DNA helicase
O6U12_13685	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
O6U12_13695	COG4496	protein, YerC YecD
O6U12_13700	COG1470	cell adhesion involved in biofilm formation
O6U12_13705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O6U12_13715	COG0531	amino acid
O6U12_13720	COG1522	sequence-specific DNA binding
O6U12_13725	COG0151	Belongs to the GarS family
O6U12_13730	COG0138	bifunctional purine biosynthesis protein purh
O6U12_13735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O6U12_13740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O6U12_13745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O6U12_13750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O6U12_13755	COG0047	phosphoribosylformylglycinamidine synthase activity
O6U12_13760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O6U12_13765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O6U12_13770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O6U12_13775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O6U12_13780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O6U12_13790	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
O6U12_13805	COG3064	Membrane
O6U12_13810	COG2252	PERMEase
O6U12_13815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O6U12_13815	COG0519	Catalyzes the synthesis of GMP from XMP
O6U12_13820	COG1305	Transglutaminase-like
O6U12_13825	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
O6U12_13830	COG0714	Associated with various cellular activities
O6U12_13835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O6U12_13845	COG1113	amino acid transport
O6U12_13850	COG2132	Multicopper oxidase
O6U12_13860	COG2267	carboxylic ester hydrolase activity
O6U12_13880	COG0823	Involved in the tonB-independent uptake of proteins
O6U12_13885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O6U12_13890	COG1063	alcohol dehydrogenase
O6U12_13895	COG2814	Major facilitator Superfamily
O6U12_13905	COG4260	virion core protein, lumpy skin disease virus
O6U12_13910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O6U12_13915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O6U12_13920	COG1842	Phage shock protein A
O6U12_13925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_13930	COG2211	Major facilitator Superfamily
O6U12_13935	COG1063	alcohol dehydrogenase
O6U12_13940	COG0457	Tetratricopeptide repeat
O6U12_13950	COG3328	transposase activity
O6U12_13980	COG0459	protein refolding
O6U12_13990	COG1266	CAAX protease self-immunity
O6U12_14000	COG0805	protein transport
O6U12_14005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O6U12_14010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O6U12_14015	COG0315	cyclic pyranopterin monophosphate synthase activity
O6U12_14020	COG0488	(ABC) transporter
O6U12_14025	COG3328	transposase activity
O6U12_14030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O6U12_14035	COG0456	acetyltransferase
O6U12_14040	COG1214	PFAM Peptidase M22, glycoprotease
O6U12_14045	COG0802	atpase or kinase
O6U12_14050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O6U12_14095	COG4124	Belongs to the glycosyl hydrolase 26 family
O6U12_14100	COG1482	cell wall glycoprotein biosynthetic process
O6U12_14105	COG1940	carbohydrate kinase activity
O6U12_14110	COG2188	Transcriptional regulator
O6U12_14115	COG2723	6-phospho-beta-galactosidase activity
O6U12_14120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_14125	COG1447	Phosphotransferase system cellobiose-specific component IIA
O6U12_14130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_14135	COG2814	Major facilitator Superfamily
O6U12_14140	COG1388	LysM domain
O6U12_14145	COG1078	dGTPase activity
O6U12_14150	COG0454	-acetyltransferase
O6U12_14160	COG5646	InterPro IPR014922
O6U12_14165	COG1785	Belongs to the alkaline phosphatase family
O6U12_14175	COG1819	glycosyl
O6U12_14180	COG1388	LysM domain
O6U12_14180	COG3858	chitin binding
O6U12_14185	COG1802	Transcriptional regulator
O6U12_14190	COG0730	response to heat
O6U12_14195	COG2814	Major facilitator Superfamily
O6U12_14200	COG1846	Transcriptional regulator
O6U12_14205	COG0778	Nitroreductase
O6U12_14210	COG2409	Drug exporters of the RND superfamily
O6U12_14210	COG1033	growth of symbiont in host cell
O6U12_14215	COG1846	Transcriptional regulator
O6U12_14220	COG2318	DinB family
O6U12_14225	COG1113	amino acid transport
O6U12_14240	COG0456	acetyltransferase
O6U12_14250	COG1309	transcriptional regulator
O6U12_14265	COG0071	Belongs to the small heat shock protein (HSP20) family
O6U12_14270	COG2323	membrane
O6U12_14295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_14300	COG2259	Doxx family
O6U12_14305	COG0346	lactoylglutathione lyase activity
O6U12_14310	COG0778	Nitroreductase
O6U12_14315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O6U12_14330	COG0457	Tetratricopeptide repeat
O6U12_14340	COG0789	Transcriptional regulator
O6U12_14340	COG4978	Transcriptional regulator
O6U12_14345	COG1811	Na channel or pump
O6U12_14350	COG2409	Drug exporters of the RND superfamily
O6U12_14355	COG2197	response regulator
O6U12_14360	COG4585	Histidine kinase
O6U12_14375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O6U12_14380	COG0640	Transcriptional regulator
O6U12_14385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O6U12_14390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_14395	COG0697	spore germination
O6U12_14405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O6U12_14410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O6U12_14415	COG0640	Transcriptional regulator
O6U12_14420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_14425	COG1733	regulation of RNA biosynthetic process
O6U12_14430	COG3545	Serine hydrolase
O6U12_14435	COG2030	dehydratase
O6U12_14440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_14445	COG0697	spore germination
O6U12_14450	COG1309	transcriptional regulator
O6U12_14455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_14465	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
O6U12_14475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_14480	COG3708	Transcriptional regulator
O6U12_14480	COG2207	Transcriptional regulator
O6U12_14485	COG0697	spore germination
O6U12_14490	COG2207	Transcriptional regulator
O6U12_14490	COG1917	Cupin 2, conserved barrel domain protein
O6U12_14495	COG0697	spore germination
O6U12_14500	COG1329	Transcriptional regulator
O6U12_14505	COG1278	Cold shock
O6U12_14510	COG3239	Fatty acid desaturase
O6U12_14520	COG1476	TRANSCRIPTIONal
O6U12_14530	COG3328	transposase activity
O6U12_14540	COG5444	nuclease activity
O6U12_14550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_14590	COG3091	SprT-like family
O6U12_14600	COG2183	response to ionizing radiation
O6U12_14605	COG2208	phosphoserine phosphatase activity
O6U12_14610	COG1191	sigma factor activity
O6U12_14615	COG2172	sigma factor antagonist activity
O6U12_14620	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_14625	COG2208	phosphoserine phosphatase activity
O6U12_14630	COG2172	sigma factor antagonist activity
O6U12_14635	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_14640	COG1366	Belongs to the anti-sigma-factor antagonist family
O6U12_14645	COG2337	Toxic component of a toxin-antitoxin (TA) module
O6U12_14650	COG0864	Transcriptional regulator
O6U12_14655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O6U12_14660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O6U12_14665	COG0736	holo-[acyl-carrier-protein] synthase activity
O6U12_14670	COG0705	Rhomboid family
O6U12_14675	COG3428	Bacterial PH domain
O6U12_14680	COG3402	PFAM membrane-flanked domain
O6U12_14685	COG0513	Belongs to the DEAD box helicase family
O6U12_14690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O6U12_14695	COG1181	Belongs to the D-alanine--D-alanine ligase family
O6U12_14700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_14705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O6U12_14725	COG1960	acyl-CoA dehydrogenase activity
O6U12_14735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O6U12_14740	COG1131	(ABC) transporter
O6U12_14750	COG0628	permease
O6U12_14755	COG1301	dicarboxylic acid transport
O6U12_14760	COG4565	transcriptional regulatory protein
O6U12_14765	COG3290	protein histidine kinase activity
O6U12_14770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O6U12_14775	COG3546	catalase activity
O6U12_14780	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_14785	COG0662	Cupin 2, conserved barrel domain protein
O6U12_14790	COG3729	General stress protein
O6U12_14795	COG2217	Heavy metal translocating P-type atpase
O6U12_14800	COG4876	unkown
O6U12_14805	COG2261	transglycosylase associated protein
O6U12_14810	COG1914	H( )-stimulated, divalent metal cation uptake system
O6U12_14830	COG0494	nUDIX hydrolase
O6U12_14835	COG0531	amino acid
O6U12_14845	COG1215	transferase activity, transferring glycosyl groups
O6U12_14860	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
O6U12_14865	COG0551	DNA topoisomerase type I activity
O6U12_14865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O6U12_14870	COG1522	sequence-specific DNA binding
O6U12_14875	COG2814	Major facilitator Superfamily
O6U12_14885	COG3871	stress protein (general stress protein 26)
O6U12_14890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O6U12_14895	COG1917	Cupin 2, conserved barrel domain protein
O6U12_14900	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_14905	COG2226	methyltransferase
O6U12_14910	COG0318	PFAM AMP-dependent synthetase and ligase
O6U12_14915	COG3711	transcriptional antiterminator
O6U12_14920	COG4989	oxidoreductase activity
O6U12_14925	COG0768	penicillin binding
O6U12_14930	COG2329	Antibiotic biosynthesis monooxygenase
O6U12_14940	COG2755	lipolytic protein G-D-S-L family
O6U12_14945	COG1414	Transcriptional regulator
O6U12_14950	COG1984	allophanate hydrolase subunit 2
O6U12_14955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O6U12_14960	COG4336	lyase activity
O6U12_14965	COG1914	H( )-stimulated, divalent metal cation uptake system
O6U12_14970	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O6U12_14975	COG0561	phosphatase activity
O6U12_14985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O6U12_14990	COG0412	Dienelactone hydrolase
O6U12_14995	COG0681	Belongs to the peptidase S26 family
O6U12_15000	COG0473	3-isopropylmalate dehydrogenase activity
O6U12_15005	COG0246	Mannitol dehydrogenase
O6U12_15010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_15015	COG2213	PTS system mannitol-specific
O6U12_15025	COG1349	DNA-binding transcription factor activity
O6U12_15030	COG1276	copper resistance
O6U12_15030	COG2372	response to copper ion
O6U12_15035	COG4549	nuclear export factor GLE1
O6U12_15040	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_15045	COG4975	Glucose uptake
O6U12_15050	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_15055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O6U12_15060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_15065	COG0640	Transcriptional regulator
O6U12_15070	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O6U12_15075	COG0778	Nitroreductase
O6U12_15080	COG1309	transcriptional regulator
O6U12_15085	COG2814	Major facilitator Superfamily
O6U12_15090	COG4607	ABC-type enterochelin transport system periplasmic component
O6U12_15095	COG4604	ABC transporter, ATP-binding protein
O6U12_15100	COG4605	iron ion homeostasis
O6U12_15105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_15110	COG0527	aspartate kinase activity
O6U12_15130	COG0457	Tetratricopeptide repeat
O6U12_15135	COG5002	protein histidine kinase activity
O6U12_15135	COG3850	Histidine kinase
O6U12_15140	COG0745	RESPONSE REGULATOR receiver
O6U12_15145	COG0577	efflux transmembrane transporter activity
O6U12_15150	COG1136	(ABC) transporter
O6U12_15155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O6U12_15165	COG0697	spore germination
O6U12_15175	COG5434	Belongs to the glycosyl hydrolase 28 family
O6U12_15180	COG3104	oligopeptide transport
O6U12_15185	COG0596	Alpha beta hydrolase
O6U12_15200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O6U12_15205	COG0163	prenyltransferase activity
O6U12_15210	COG0583	DNA-binding transcription factor activity
O6U12_15215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_15220	COG0765	amino acid transport
O6U12_15225	COG1126	abc transporter atp-binding protein
O6U12_15230	COG2364	Membrane
O6U12_15240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_15245	COG0697	spore germination
O6U12_15255	COG2814	Major facilitator Superfamily
O6U12_15260	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
O6U12_15265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_15270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_15290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_15295	COG1733	regulation of RNA biosynthetic process
O6U12_15300	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
O6U12_15305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O6U12_15310	COG0840	transmembrane signaling receptor activity
O6U12_15310	COG3290	protein histidine kinase activity
O6U12_15315	COG3209	COG3209 Rhs family protein
O6U12_15325	COG2723	6-phospho-beta-galactosidase activity
O6U12_15330	COG3842	ATPase activity
O6U12_15340	COG1846	Transcriptional regulator
O6U12_15350	COG1714	RDD family
O6U12_15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_15365	COG0765	amino acid transport
O6U12_15370	COG0523	cobalamin synthesis protein
O6U12_15385	COG1376	ErfK ybiS ycfS ynhG family protein
O6U12_15390	COG1469	GTP cyclohydrolase I activity
O6U12_15395	COG2223	nitrite transmembrane transporter activity
O6U12_15400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O6U12_15405	COG0243	molybdopterin cofactor binding
O6U12_15410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O6U12_15415	COG2146	nitrite reductase [NAD(P)H] activity
O6U12_15420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O6U12_15420	COG1587	Uroporphyrinogen-III synthase
O6U12_15425	COG0492	ferredoxin-NADP+ reductase activity
O6U12_15430	COG2267	carboxylic ester hydrolase activity
O6U12_15435	COG0701	Predicted permease
O6U12_15440	COG3689	TIGRFAM TIGR03943 family protein
O6U12_15445	COG2508	Transcriptional regulator
O6U12_15450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_15455	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_15460	COG0506	proline dehydrogenase activity
O6U12_15465	COG3541	Predicted nucleotidyltransferase
O6U12_15470	COG3458	cephalosporin-C deacetylase activity
O6U12_15475	COG0583	DNA-binding transcription factor activity
O6U12_15480	COG2226	methyltransferase
O6U12_15485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O6U12_15495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O6U12_15500	COG3665	Urea carboxylase-associated protein
O6U12_15510	COG3403	YqcI/YcgG family
O6U12_15520	COG1620	l-lactate permease
O6U12_15525	COG0039	L-malate dehydrogenase activity
O6U12_15545	COG1288	antiporter activity
O6U12_15550	COG1473	amidohydrolase
O6U12_15555	COG2113	Glycine betaine
O6U12_15560	COG4176	ABC-type proline glycine betaine transport system permease component
O6U12_15565	COG4175	Glycine betaine
O6U12_15565	COG0517	IMP dehydrogenase activity
O6U12_15570	COG0640	Transcriptional regulator
O6U12_15575	COG2814	Major facilitator Superfamily
O6U12_15580	COG0477	Major facilitator Superfamily
O6U12_15585	COG3853	Toxic anion resistance protein (TelA)
O6U12_15595	COG0861	Integral membrane protein TerC family
O6U12_15600	COG2310	stress, protein
O6U12_15605	COG2310	stress, protein
O6U12_15610	COG2310	stress, protein
O6U12_15615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_15620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O6U12_15625	COG1121	(ABC) transporter
O6U12_15630	COG0803	Belongs to the bacterial solute-binding protein 9 family
O6U12_15640	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_15650	COG1876	peptidase activity
O6U12_15655	COG1595	DNA-templated transcription, initiation
O6U12_15660	COG1595	DNA-templated transcription, initiation
O6U12_15675	COG0667	Aldo Keto reductase
O6U12_15680	COG1668	transmembrane transport
O6U12_15685	COG4555	ABC transporter
O6U12_15690	COG3279	Response regulator of the LytR AlgR family
O6U12_15700	COG3012	SEC-C Motif Domain Protein
O6U12_15700	COG1405	negative regulation of cell septum assembly
O6U12_15705	COG1714	RDD family
O6U12_15710	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O6U12_15715	COG0252	asparaginase activity
O6U12_15720	COG1309	transcriptional regulator
O6U12_15725	COG0477	Major facilitator Superfamily
O6U12_15730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O6U12_15735	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
O6U12_15740	COG0805	protein transport
O6U12_15745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O6U12_15750	COG3540	Alkaline phosphatase
O6U12_15765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O6U12_15770	COG1279	arginine transmembrane transporter activity
O6U12_15775	COG0626	cystathionine gamma-synthase activity
O6U12_15780	COG0137	argininosuccinate synthase activity
O6U12_15795	COG0531	amino acid
O6U12_15825	COG0072	phenylalanine-tRNA ligase activity
O6U12_15825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_15835	COG3773	Cell wall hydrolase
O6U12_15855	COG1131	(ABC) transporter
O6U12_15860	COG2205	protein histidine kinase activity
O6U12_15865	COG0745	RESPONSE REGULATOR receiver
O6U12_15870	COG0697	spore germination
O6U12_15885	COG2721	sulfolactate sulfo-lyase activity
O6U12_15890	COG2186	Transcriptional regulator
O6U12_15895	COG4948	Mandelate Racemase Muconate Lactonizing
O6U12_15900	COG2271	Major facilitator Superfamily
O6U12_15905	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_15910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O6U12_15915	COG0784	Response regulator, receiver
O6U12_15920	COG4191	Histidine kinase
O6U12_15925	COG2066	Belongs to the glutaminase family
O6U12_15930	COG1115	amino acid carrier protein
O6U12_15935	COG2040	homocysteine
O6U12_15940	COG0833	amino acid
O6U12_15945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_15955	COG2188	Transcriptional regulator
O6U12_15960	COG0363	glucosamine-6-phosphate deaminase activity
O6U12_15970	COG1301	dicarboxylic acid transport
O6U12_15975	COG1054	Belongs to the UPF0176 family
O6U12_15980	COG2312	Erythromycin esterase
O6U12_15990	COG0688	phosphatidylethanolamine metabolic process
O6U12_15995	COG0586	Pfam SNARE associated Golgi protein
O6U12_16000	COG1183	phosphatidylcholine synthase activity
O6U12_16005	COG0596	Alpha beta hydrolase
O6U12_16015	COG3591	Belongs to the peptidase S1B family
O6U12_16020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O6U12_16025	COG1917	Cupin 2, conserved barrel domain protein
O6U12_16025	COG2207	Transcriptional regulator
O6U12_16030	COG0697	spore germination
O6U12_16035	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_16045	COG2271	Major facilitator Superfamily
O6U12_16050	COG1846	Transcriptional regulator
O6U12_16050	COG0456	acetyltransferase
O6U12_16060	COG2271	Major facilitator Superfamily
O6U12_16065	COG0584	glycerophosphoryl diester phosphodiesterase
O6U12_16070	COG0531	amino acid
O6U12_16080	COG2124	cytochrome p450
O6U12_16085	COG2602	Beta-lactamase
O6U12_16100	COG1113	amino acid transport
O6U12_16115	COG0515	serine threonine protein kinase
O6U12_16125	COG0642	Histidine kinase
O6U12_16130	COG0745	RESPONSE REGULATOR receiver
O6U12_16135	COG0596	Alpha beta hydrolase
O6U12_16140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_16145	COG1413	lyase activity
O6U12_16155	COG1131	(ABC) transporter
O6U12_16160	COG1266	CAAX protease self-immunity
O6U12_16165	COG0535	radical SAM domain protein
O6U12_16180	COG2814	Major facilitator Superfamily
O6U12_16185	COG0640	Transcriptional regulator
O6U12_16190	COG5609	conserved protein (DUF2294)
O6U12_16200	COG0288	reversible hydration of carbon dioxide
O6U12_16205	COG3002	Belongs to the UPF0753 family
O6U12_16210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O6U12_16215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O6U12_16220	COG2169	Transcriptional regulator
O6U12_16225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O6U12_16310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_16325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O6U12_16330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O6U12_16335	COG4856	YbbR-like protein
O6U12_16340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O6U12_16345	COG5662	AntiSigma factor
O6U12_16350	COG1595	DNA-templated transcription, initiation
O6U12_16380	COG1683	Conserved Protein
O6U12_16390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O6U12_16395	COG1737	Transcriptional regulator
O6U12_16400	COG1263	PTS System
O6U12_16400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_16405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O6U12_16415	COG3876	Protein conserved in bacteria
O6U12_16420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_16420	COG2207	Transcriptional regulator
O6U12_16425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_16430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_16435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_16440	COG2819	hydrolase of the alpha beta superfamily
O6U12_16445	COG0385	Bile acid
O6U12_16450	COG0659	secondary active sulfate transmembrane transporter activity
O6U12_16520	COG0726	polysaccharide deacetylase
O6U12_16525	COG2194	sulfuric ester hydrolase activity
O6U12_16535	COG0489	protein tyrosine kinase activity
O6U12_16540	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_16550	COG2226	methyltransferase
O6U12_16555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O6U12_16560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O6U12_16565	COG0101	tRNA pseudouridine synthase activity
O6U12_16570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O6U12_16575	COG1122	ATPase activity
O6U12_16580	COG1122	ATPase activity
O6U12_16585	COG0203	ribosomal protein L17
O6U12_16590	COG0202	RNA polymerase activity
O6U12_16595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O6U12_16600	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O6U12_16605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O6U12_16615	COG2163	COG2163 Ribosomal protein L14E L6E L27E
O6U12_16620	COG0024	Methionine aminopeptidase
O6U12_16625	COG0563	adenylate kinase activity
O6U12_16630	COG0201	protein transport
O6U12_16635	COG0200	Binds to the 23S rRNA
O6U12_16645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O6U12_16650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O6U12_16655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O6U12_16660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O6U12_16670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O6U12_16685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O6U12_16695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O6U12_16700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O6U12_16715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O6U12_16725	COG0088	Forms part of the polypeptide exit tunnel
O6U12_16730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O6U12_16740	COG0596	Alpha beta hydrolase
O6U12_16745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O6U12_16750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O6U12_16755	COG0049	tRNA binding
O6U12_16760	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O6U12_16765	COG1358	cellular component organization or biogenesis
O6U12_16770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O6U12_16775	COG0085	RNA polymerase activity
O6U12_16780	COG2813	Specifically methylates the guanine in position
O6U12_16790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O6U12_16795	COG0081	regulation of translation
O6U12_16805	COG0250	Participates in transcription elongation, termination and antitermination
O6U12_16810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O6U12_16820	COG1595	DNA-templated transcription, initiation
O6U12_16825	COG3688	RNA-binding protein containing a PIN domain
O6U12_16830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O6U12_16835	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
O6U12_16840	COG0215	cysteine-tRNA ligase activity
O6U12_16845	COG1045	serine acetyltransferase
O6U12_16850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O6U12_16855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O6U12_16860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O6U12_16865	COG4956	integral membrane protein (PIN domain superfamily)
O6U12_16870	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O6U12_16875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O6U12_16880	COG0542	response to heat
O6U12_16885	COG3869	Catalyzes the specific phosphorylation of arginine residues in
O6U12_16890	COG3880	PFAM UvrB UvrC protein
O6U12_16895	COG4463	regulation of RNA biosynthetic process
O6U12_16975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O6U12_16980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O6U12_16985	COG1396	sequence-specific DNA binding
O6U12_16990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O6U12_16995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O6U12_17000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O6U12_17005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_17010	COG0512	Glutamine amidotransferase of anthranilate synthase
O6U12_17015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O6U12_17020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O6U12_17025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O6U12_17030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O6U12_17035	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O6U12_17040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O6U12_17045	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O6U12_17050	COG0037	tRNA processing
O6U12_17055	COG0515	serine threonine protein kinase
O6U12_17060	COG2304	oxidoreductase activity
O6U12_17065	COG2208	phosphoserine phosphatase activity
O6U12_17080	COG1098	S1 RNA binding domain
O6U12_17085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O6U12_17100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O6U12_17105	COG3956	TIGRFAM MazG family protein
O6U12_17110	COG2244	polysaccharide biosynthetic process
O6U12_17115	COG2002	toxin-antitoxin pair type II binding
O6U12_17120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O6U12_17130	COG0193	aminoacyl-tRNA hydrolase activity
O6U12_17135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O6U12_17140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O6U12_17145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O6U12_17150	COG2088	sporulation resulting in formation of a cellular spore
O6U12_17155	COG0251	oxidation-reduction process
O6U12_17160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O6U12_17165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O6U12_17175	COG4466	Protein conserved in bacteria
O6U12_17185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O6U12_17190	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O6U12_17195	COG3583	domain protein
O6U12_17195	COG3584	3D domain protein
O6U12_17200	COG0084	hydrolase, TatD family'
O6U12_17205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_17205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O6U12_17210	COG2002	toxin-antitoxin pair type II binding
O6U12_17215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O6U12_17220	COG2827	Endonuclease containing a URI domain
O6U12_17225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O6U12_17230	COG4467	Involved in initiation control of chromosome replication
O6U12_17235	COG1774	PSP1 C-terminal conserved region
O6U12_17240	COG0470	DNA polymerase III
O6U12_17245	COG1728	Protein conserved in bacteria
O6U12_17250	COG3870	Protein conserved in bacteria
O6U12_17255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O6U12_17260	COG1982	Orn Lys Arg decarboxylase major
O6U12_17265	COG3853	Toxic anion resistance protein (TelA)
O6U12_17270	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
O6U12_17315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O6U12_17320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O6U12_17325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O6U12_17335	COG0590	tRNA wobble adenosine to inosine editing
O6U12_17340	COG1335	isochorismatase
O6U12_17345	COG3858	chitin binding
O6U12_17345	COG1388	LysM domain
O6U12_17350	COG1428	Deoxynucleoside kinase
O6U12_17355	COG1428	Deoxynucleoside kinase
O6U12_17365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O6U12_17370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O6U12_17375	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O6U12_17380	COG1686	Belongs to the peptidase S11 family
O6U12_17385	COG0516	GMP reductase activity
O6U12_17385	COG0517	IMP dehydrogenase activity
O6U12_17425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O6U12_17430	COG0187	DNA topoisomerase II activity
O6U12_17440	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O6U12_17445	COG2501	S4 domain
O6U12_17450	COG0592	DNA-directed DNA polymerase activity
O6U12_17455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O6U12_17465	COG0594	ribonuclease P activity
O6U12_17470	COG0706	membrane insertase activity
O6U12_17475	COG1847	R3H domain protein
O6U12_17480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O6U12_17485	COG0445	tRNA wobble uridine modification
O6U12_17490	COG0357	Ribosomal RNA small subunit methyltransferase G
O6U12_17495	COG1475	DNA binding
O6U12_17505	COG1192	Involved in chromosome partitioning
O6U12_17510	COG1475	DNA binding
O6U12_17520	COG3949	Membrane
O6U12_17525	COG4481	Protein conserved in bacteria
O6U12_17530	COG0243	molybdopterin cofactor binding
O6U12_17535	COG0012	GTP binding
O6U12_17540	COG0360	Binds together with S18 to 16S ribosomal RNA
O6U12_17545	COG0629	single-stranded DNA binding
O6U12_17550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O6U12_17555	COG0708	Exodeoxyribonuclease III
O6U12_17560	COG1609	Transcriptional regulator
O6U12_17565	COG0346	lactoylglutathione lyase activity
O6U12_17570	COG0110	maltose O-acetyltransferase activity
O6U12_17575	COG0477	Major facilitator Superfamily
O6U12_17575	COG2814	Major facilitator Superfamily
O6U12_17580	COG1266	CAAX protease self-immunity
O6U12_17585	COG1331	Highly conserved protein containing a thioredoxin domain
O6U12_17590	COG2814	Major facilitator Superfamily
O6U12_17600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O6U12_17610	COG0456	acetyltransferase
O6U12_17615	COG2364	Membrane
O6U12_17625	COG1846	Transcriptional regulator
O6U12_17630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O6U12_17645	COG2153	protein acetylation
O6U12_17650	COG0583	DNA-binding transcription factor activity
O6U12_17655	COG2814	Major facilitator Superfamily
O6U12_17660	COG1357	PFAM Pentapeptide repeats (8 copies)
O6U12_17665	COG4319	ketosteroid isomerase
O6U12_17680	COG2271	Major facilitator Superfamily
O6U12_17695	COG1227	inorganic diphosphatase activity
O6U12_17700	COG1733	regulation of RNA biosynthetic process
O6U12_17715	COG4241	membrane
O6U12_17720	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
O6U12_17725	COG0359	binds to the 23S rRNA
O6U12_17730	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O6U12_17735	COG2807	transmembrane transport
O6U12_17740	COG3093	addiction module antidote protein HigA
O6U12_17755	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_17760	COG0346	lactoylglutathione lyase activity
O6U12_17790	COG0745	RESPONSE REGULATOR receiver
O6U12_17795	COG5002	protein histidine kinase activity
O6U12_17800	COG4863	YycH protein
O6U12_17805	COG4853	Protein conserved in bacteria
O6U12_17810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O6U12_17815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_17830	COG3829	transcription factor binding
O6U12_17835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O6U12_17840	COG0833	amino acid
O6U12_17845	COG0010	Belongs to the arginase family
O6U12_17855	COG0457	Tetratricopeptide repeat
O6U12_17860	COG0456	acetyltransferase
O6U12_17865	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
O6U12_17885	COG1063	alcohol dehydrogenase
O6U12_17900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O6U12_17935	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
O6U12_17945	COG0535	radical SAM domain protein
O6U12_17950	COG1994	Peptidase M50
O6U12_17955	COG1131	(ABC) transporter
O6U12_17970	COG2188	Transcriptional regulator
O6U12_17985	COG2723	6-phospho-beta-galactosidase activity
O6U12_17990	COG3634	alkyl hydroperoxide reductase activity
O6U12_17995	COG0450	alkyl hydroperoxide reductase
O6U12_18000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O6U12_18005	COG2610	gluconate transmembrane transporter activity
O6U12_18010	COG1070	Carbohydrate kinase
O6U12_18015	COG1802	Transcriptional regulator
O6U12_18020	COG1929	Belongs to the glycerate kinase type-1 family
O6U12_18030	COG1346	cytolysis
O6U12_18035	COG1380	Effector of murein hydrolase LrgA
O6U12_18040	COG1846	Transcriptional regulator
O6U12_18050	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_18055	COG1309	transcriptional regulator
O6U12_18060	COG1917	Cupin 2, conserved barrel domain protein
O6U12_18065	COG2311	Membrane
O6U12_18070	COG1714	RDD family
O6U12_18080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O6U12_18095	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_18100	COG1309	transcriptional regulator
O6U12_18105	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_18115	COG0326	Molecular chaperone. Has ATPase activity
O6U12_18120	COG2814	Major facilitator Superfamily
O6U12_18135	COG0667	Aldo Keto reductase
O6U12_18140	COG1349	DNA-binding transcription factor activity
O6U12_18145	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_18150	COG3718	enzyme involved in inositol metabolism
O6U12_18155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_18160	COG3962	Belongs to the TPP enzyme family
O6U12_18165	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_18170	COG2814	Major facilitator Superfamily
O6U12_18175	COG0673	inositol 2-dehydrogenase activity
O6U12_18180	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_18185	COG1082	Xylose isomerase domain protein TIM barrel
O6U12_18190	COG0191	fructose-bisphosphate aldolase activity
O6U12_18195	COG0745	RESPONSE REGULATOR receiver
O6U12_18200	COG2205	protein histidine kinase activity
O6U12_18205	COG1136	(ABC) transporter
O6U12_18210	COG0577	efflux transmembrane transporter activity
O6U12_18215	COG5294	Protein conserved in bacteria
O6U12_18220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_18250	COG0561	phosphatase activity
O6U12_18255	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
O6U12_18260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_18265	COG0456	acetyltransferase
O6U12_18270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O6U12_18275	COG0765	amino acid transport
O6U12_18280	COG1126	abc transporter atp-binding protein
O6U12_18285	COG1473	amidohydrolase
O6U12_18290	COG2079	MmgE PrpD family protein
O6U12_18295	COG3192	ethanolamine utilization protein
O6U12_18305	COG2390	Transcriptional regulator
O6U12_18310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O6U12_18315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O6U12_18320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O6U12_18335	COG1228	amidohydrolase
O6U12_18345	COG3507	Belongs to the glycosyl hydrolase 43 family
O6U12_18350	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
O6U12_18355	COG0494	nUDIX hydrolase
O6U12_18375	COG5444	nuclease activity
O6U12_18385	COG1263	PTS System
O6U12_18385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_18385	COG2190	(PTS) system
O6U12_18390	COG2723	6-phospho-beta-galactosidase activity
O6U12_18395	COG0589	response to stress
O6U12_18405	COG0697	spore germination
O6U12_18410	COG3209	COG3209 Rhs family protein
O6U12_18465	COG2755	lipolytic protein G-D-S-L family
O6U12_18465	COG3401	FG-GAP repeat protein
O6U12_18470	COG0513	Belongs to the DEAD box helicase family
O6U12_18475	COG2270	Major facilitator Superfamily
O6U12_18495	COG2851	Citrate transporter
O6U12_18500	COG0693	protein deglycase activity
O6U12_18500	COG0753	catalase activity
O6U12_18515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O6U12_18530	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_18550	COG3546	catalase activity
O6U12_18570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O6U12_18585	COG2323	membrane
O6U12_18595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_18600	COG2323	membrane
O6U12_18605	COG0500	methyltransferase
O6U12_18610	COG2610	gluconate transmembrane transporter activity
O6U12_18615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O6U12_18620	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O6U12_18630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O6U12_18635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O6U12_18640	COG4894	glucomannan catabolic process
O6U12_18655	COG2195	Cleaves the N-terminal amino acid of tripeptides
O6U12_18660	COG2197	response regulator
O6U12_18665	COG4585	Histidine kinase
O6U12_18675	COG0583	DNA-binding transcription factor activity
O6U12_18680	COG1881	PFAM PEBP family protein
O6U12_18685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O6U12_18695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_18700	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_18705	COG2508	Transcriptional regulator
O6U12_18710	COG3842	ATPase activity
O6U12_18715	COG0726	polysaccharide deacetylase
O6U12_18725	COG0501	Belongs to the peptidase M48B family
O6U12_18730	COG3493	citrate carrier protein
O6U12_18735	COG1271	oxidase subunit
O6U12_18740	COG1294	oxidase, subunit
O6U12_18745	COG4988	ABC transporter
O6U12_18750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O6U12_18755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O6U12_18760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O6U12_18765	COG1595	DNA-templated transcription, initiation
O6U12_18785	COG1131	(ABC) transporter
O6U12_18800	COG0753	catalase activity
O6U12_18805	COG2094	Belongs to the DNA glycosylase MPG family
O6U12_18815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_18815	COG3711	transcriptional antiterminator
O6U12_18820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_18825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O6U12_18830	COG1447	Phosphotransferase system cellobiose-specific component IIA
O6U12_18835	COG1486	melibiose metabolic process
O6U12_18840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O6U12_18845	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
O6U12_18850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
O6U12_18855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O6U12_18860	COG1696	Membrane protein involved in D-alanine export
O6U12_18865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O6U12_18880	COG1575	Belongs to the MenA family. Type 1 subfamily
O6U12_18885	COG2357	RelA SpoT domain protein
O6U12_18890	COG2814	Major facilitator Superfamily
O6U12_18910	COG2234	aminopeptidase activity
O6U12_18915	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O6U12_18920	COG1846	Transcriptional regulator
O6U12_18930	COG1442	glycosyl transferase family 8
O6U12_18935	COG3711	transcriptional antiterminator
O6U12_18940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_18940	COG1263	PTS System
O6U12_18945	COG1404	Belongs to the peptidase S8 family
O6U12_18960	COG0346	lactoylglutathione lyase activity
O6U12_18965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O6U12_18970	COG4895	conserved protein (DUF2196)
O6U12_18975	COG2814	Major facilitator Superfamily
O6U12_18980	COG1346	cytolysis
O6U12_18985	COG1380	Effector of murein hydrolase LrgA
O6U12_18990	COG0583	DNA-binding transcription factor activity
O6U12_18995	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
O6U12_19000	COG0352	thiamine-phosphate diphosphorylase activity
O6U12_19005	COG0672	)-iron permease
O6U12_19010	COG2822	iron ion transport
O6U12_19015	COG2837	iron assimilation
O6U12_19020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O6U12_19025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O6U12_19030	COG3162	membrane
O6U12_19040	COG1309	transcriptional regulator
O6U12_19045	COG2246	polysaccharide biosynthetic process
O6U12_19050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O6U12_19055	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
O6U12_19060	COG2261	transglycosylase associated protein
O6U12_19065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O6U12_19070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O6U12_19075	COG1845	cytochrome c oxidase, subunit III
O6U12_19080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O6U12_19095	COG0772	Belongs to the SEDS family
O6U12_19100	COG0778	Nitroreductase
O6U12_19105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_19110	COG1404	Belongs to the peptidase S8 family
O6U12_19120	COG3711	transcriptional antiterminator
O6U12_19125	COG2116	formate transmembrane transporter activity
O6U12_19130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O6U12_19130	COG1263	PTS System
O6U12_19135	COG1621	beta-fructofuranosidase activity
O6U12_19145	COG0351	phosphomethylpyrimidine kinase
O6U12_19150	COG1695	Transcriptional regulator
O6U12_19165	COG1216	Glycosyl transferase, family 2
O6U12_19170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O6U12_19175	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_19185	COG2233	PERMEase
O6U12_19190	COG2363	Small membrane protein
O6U12_19200	COG0463	Glycosyl transferase, family 2
O6U12_19205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_19210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O6U12_19215	COG0456	acetyltransferase
O6U12_19220	COG2089	acid synthase
O6U12_19225	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
O6U12_19230	COG3980	spore coat polysaccharide biosynthesis protein
O6U12_19235	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O6U12_19240	COG1088	dTDP-glucose 4,6-dehydratase activity
O6U12_19245	COG1091	dTDP-4-dehydrorhamnose reductase activity
O6U12_19250	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
O6U12_19265	COG1012	belongs to the aldehyde dehydrogenase family
O6U12_19270	COG4187	Peptidase family M20/M25/M40
O6U12_19275	COG0833	amino acid
O6U12_19280	COG2814	Major facilitator Superfamily
O6U12_19285	COG0077	Prephenate dehydratase
O6U12_19295	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_19300	COG0151	Belongs to the GarS family
O6U12_19305	COG2814	Major facilitator Superfamily
O6U12_19310	COG0436	Aminotransferase
O6U12_19320	COG3253	May function as heme-dependent peroxidase
O6U12_19325	COG0280	phosphate acetyltransferase
O6U12_19330	COG0583	DNA-binding transcription factor activity
O6U12_19335	COG0095	Lipoate-protein ligase
O6U12_19340	COG0697	spore germination
O6U12_19350	COG4844	belongs to the
O6U12_19355	COG1078	dGTPase activity
O6U12_19360	COG3465	dGTPase activity
O6U12_19365	COG1959	2 iron, 2 sulfur cluster binding
O6U12_19370	COG0477	Major facilitator Superfamily
O6U12_19375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O6U12_19380	COG1846	Transcriptional regulator
O6U12_19385	COG1942	4-Oxalocrotonate Tautomerase
O6U12_19390	COG1994	Peptidase M50
O6U12_19400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O6U12_19405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O6U12_19410	COG0010	Belongs to the arginase family
O6U12_19425	COG0457	Tetratricopeptide repeat
O6U12_19430	COG3391	amine dehydrogenase activity
O6U12_19435	COG3391	amine dehydrogenase activity
O6U12_19445	COG0612	Peptidase, M16
O6U12_19450	COG0612	Peptidase, M16
O6U12_19455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O6U12_19460	COG1131	(ABC) transporter
O6U12_19470	COG0535	radical SAM domain protein
O6U12_19485	COG4506	Protein conserved in bacteria
O6U12_19490	COG0018	arginyl-trna synthetase
O6U12_19495	COG2223	nitrite transmembrane transporter activity
O6U12_19500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O6U12_19510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O6U12_19515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
O6U12_19520	COG1140	nitrate reductase beta subunit
O6U12_19525	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
O6U12_19530	COG2181	nitrate reductase activity
O6U12_19540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_19545	COG1132	(ABC) transporter
O6U12_19550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O6U12_19560	COG4294	response to UV
O6U12_19565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_19570	COG0247	lactate metabolic process
O6U12_19570	COG2181	nitrate reductase activity
O6U12_19575	COG1960	acyl-CoA dehydrogenase activity
O6U12_19580	COG3343	RNA polymerase activity
O6U12_19585	COG0504	CTP synthase activity
O6U12_19590	COG2801	Transposase and inactivated derivatives
O6U12_19600	COG4821	SIS domain
O6U12_19605	COG2204	response regulator
O6U12_19610	COG0191	fructose-bisphosphate aldolase activity
O6U12_19615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O6U12_19620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O6U12_19625	COG1494	fructose-1,6-bisphosphatase
O6U12_19635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O6U12_19645	COG1435	thymidine kinase activity
O6U12_19650	COG0281	malic enzyme
O6U12_19655	COG0679	Auxin Efflux Carrier
O6U12_19660	COG0789	Transcriptional regulator
O6U12_19665	COG0346	lactoylglutathione lyase activity
O6U12_19670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O6U12_19675	COG2890	protein-(glutamine-N5) methyltransferase activity
O6U12_19695	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O6U12_19700	COG0009	L-threonylcarbamoyladenylate synthase
O6U12_19705	COG1971	Probably functions as a manganese efflux pump
O6U12_19710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O6U12_19715	COG0698	ribose 5-phosphate isomerase
O6U12_19720	COG4475	Protein of unknown function (DUF436)
O6U12_19725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O6U12_19730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O6U12_19740	COG0356	it plays a direct role in the translocation of protons across the membrane
O6U12_19750	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O6U12_19755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O6U12_19760	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O6U12_19765	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O6U12_19770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O6U12_19775	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O6U12_19785	COG4836	Membrane
O6U12_19795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O6U12_19800	COG2385	sporulation resulting in formation of a cellular spore
O6U12_19815	COG2304	oxidoreductase activity
O6U12_19825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O6U12_19830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O6U12_19835	COG0457	Tetratricopeptide repeat
O6U12_19840	COG1994	Peptidase M50
O6U12_19845	COG3237	CsbD-like
O6U12_19875	COG0831	urea catabolic process
O6U12_19880	COG0832	Belongs to the urease beta subunit family
O6U12_19885	COG0804	urea catabolic process
O6U12_19890	COG1959	2 iron, 2 sulfur cluster binding
O6U12_19895	COG2910	NAD(P)H-binding
O6U12_19905	COG0789	Transcriptional regulator
O6U12_19910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O6U12_19930	COG1247	-acetyltransferase
O6U12_19935	COG0739	heme binding
O6U12_19945	COG0671	phosphoesterase, PA-phosphatase related
O6U12_19950	COG0347	Belongs to the P(II) protein family
O6U12_19955	COG0004	ammonium transporteR
O6U12_19965	COG1335	isochorismatase
O6U12_19970	COG0477	Major facilitator Superfamily
O6U12_19975	COG1953	Uracil, thiamine, allantoin
O6U12_19980	COG3420	alginic acid biosynthetic process
O6U12_19985	COG2814	Major facilitator Superfamily
O6U12_19990	COG1846	Transcriptional regulator
O6U12_20000	COG1609	Transcriptional regulator
O6U12_20005	COG1077	Cell shape determining protein MreB Mrl
O6U12_20010	COG4786	Flagellar basal body rod
O6U12_20015	COG4786	Flagellar basal body rod
O6U12_20020	COG0457	Tetratricopeptide repeat
O6U12_20025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O6U12_20030	COG1970	mechanosensitive ion channel activity
O6U12_20035	COG0745	RESPONSE REGULATOR receiver
O6U12_20035	COG2972	Histidine kinase
O6U12_20050	COG3328	transposase activity
O6U12_20065	COG0629	single-stranded DNA binding
O6U12_20070	COG1349	DNA-binding transcription factor activity
O6U12_20075	COG0561	phosphatase activity
O6U12_20080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O6U12_20085	COG4715	Zinc finger, swim domain protein
O6U12_20095	COG3944	biosynthesis protein
O6U12_20100	COG0489	protein tyrosine kinase activity
O6U12_20105	COG4464	protein tyrosine phosphatase activity
O6U12_20110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O6U12_20130	COG5444	nuclease activity
O6U12_20145	COG0583	DNA-binding transcription factor activity
O6U12_20160	COG2059	Chromate
O6U12_20165	COG2059	Chromate
O6U12_20170	COG1522	sequence-specific DNA binding
O6U12_20175	COG0405	Gamma-glutamyltransferase
O6U12_20185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O6U12_20195	COG5337	Spore coat protein CotH
O6U12_20215	COG0583	DNA-binding transcription factor activity
O6U12_20220	COG0028	Belongs to the TPP enzyme family
O6U12_20225	COG3527	Alpha-acetolactate decarboxylase
O6U12_20230	COG2249	NAD(P)H dehydrogenase (quinone) activity
O6U12_20240	COG3103	Sh3 type 3 domain protein
O6U12_20245	COG1879	ABC-type sugar transport system periplasmic component
O6U12_20250	COG1172	Belongs to the binding-protein-dependent transport system permease family
O6U12_20255	COG1129	ABC transporter
O6U12_20260	COG1869	D-ribose catabolic process
O6U12_20265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O6U12_20270	COG1609	Transcriptional regulator
O6U12_20275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O6U12_20285	COG2843	Capsule synthesis protein
O6U12_20295	COG0791	NLP P60 protein
O6U12_20305	COG0561	phosphatase activity
O6U12_20310	COG1316	TRANSCRIPTIONal
O6U12_20315	COG2814	Major facilitator Superfamily
O6U12_20325	COG0814	amino acid
O6U12_20330	COG0697	spore germination
O6U12_20335	COG1482	cell wall glycoprotein biosynthetic process
O6U12_20340	COG4193	domain, Protein
O6U12_20350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_20355	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O6U12_20360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O6U12_20365	COG0438	transferase activity, transferring glycosyl groups
O6U12_20370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_20375	COG1682	transport, permease protein
O6U12_20380	COG1134	teichoic acid transport
O6U12_20400	COG0463	Glycosyl transferase, family 2
O6U12_20405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O6U12_20405	COG1215	transferase activity, transferring glycosyl groups
O6U12_20415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O6U12_20420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O6U12_20425	COG1316	TRANSCRIPTIONal
O6U12_20435	COG2385	sporulation resulting in formation of a cellular spore
O6U12_20435	COG2247	cell wall binding repeat
O6U12_20440	COG2247	cell wall binding repeat
O6U12_20440	COG0860	N-Acetylmuramoyl-L-alanine amidase
O6U12_20450	COG2244	polysaccharide biosynthetic process
O6U12_20455	COG0438	transferase activity, transferring glycosyl groups
O6U12_20455	COG0297	glycogen (starch) synthase activity
O6U12_20460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O6U12_20465	COG3307	-O-antigen
O6U12_20470	COG3206	protein involved in exopolysaccharide biosynthesis
O6U12_20475	COG1215	transferase activity, transferring glycosyl groups
O6U12_20480	COG0438	transferase activity, transferring glycosyl groups
O6U12_20485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O6U12_20490	COG1316	TRANSCRIPTIONal
O6U12_20495	COG1739	Uncharacterized protein family UPF0029
O6U12_20500	COG4585	Histidine kinase
O6U12_20505	COG2197	response regulator
O6U12_20510	COG1307	EDD domain protein, DegV family
O6U12_20515	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
O6U12_20525	COG1040	competence protein
O6U12_20535	COG2747	anti-sigma28 factor FlgM
O6U12_20540	COG3418	PFAM FlgN family protein
O6U12_20545	COG4786	Flagellar basal body rod
O6U12_20545	COG1256	bacterial-type flagellum assembly
O6U12_20550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O6U12_20560	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
O6U12_20565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O6U12_20570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O6U12_20575	COG1334	flagellar protein FlaG
O6U12_20580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O6U12_20585	COG1516	flagellar protein fliS
O6U12_20600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O6U12_20605	COG0653	protein targeting
O6U12_20615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O6U12_20620	COG2010	Cytochrome c
O6U12_20625	COG2884	Cell division ATP-binding protein ftsE
O6U12_20630	COG2177	Part of the ABC transporter FtsEX involved in
O6U12_20635	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_20635	COG0793	Belongs to the peptidase S41A family
O6U12_20645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_20650	COG2814	Major facilitator Superfamily
O6U12_20655	COG1309	transcriptional regulator
O6U12_20660	COG0574	Belongs to the PEP-utilizing enzyme family
O6U12_20660	COG3848	Pyruvate phosphate dikinase
O6U12_20665	COG4897	Protein conserved in bacteria
O6U12_20670	COG0556	nucleotide-excision repair
O6U12_20675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O6U12_20695	COG3595	metallopeptidase activity
O6U12_20700	COG1983	PspC domain protein
O6U12_20705	COG1950	PFAM Membrane protein of
O6U12_20710	COG2814	Major facilitator Superfamily
O6U12_20715	COG1846	Transcriptional regulator
O6U12_20725	COG2124	cytochrome p450
O6U12_20730	COG1846	Transcriptional regulator
O6U12_20735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O6U12_20740	COG2188	Transcriptional regulator
O6U12_20745	COG0363	glucosamine-6-phosphate deaminase activity
O6U12_20750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O6U12_20755	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
O6U12_20760	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O6U12_20765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
O6U12_20770	COG0546	phosphoglycolate phosphatase activity
O6U12_20775	COG0110	maltose O-acetyltransferase activity
O6U12_20780	COG5297	Belongs to the glycosyl hydrolase family 6
O6U12_20785	COG4990	cell redox homeostasis
O6U12_20790	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O6U12_20795	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O6U12_20800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O6U12_20805	COG0131	Imidazoleglycerol-phosphate dehydratase
O6U12_20810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O6U12_20815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O6U12_20820	COG0107	imidazoleglycerol-phosphate synthase activity
O6U12_20825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O6U12_20825	COG0140	phosphoribosyl-ATP diphosphatase activity
O6U12_20850	COG0457	Tetratricopeptide repeat
O6U12_20855	COG0791	NLP P60 protein
O6U12_20855	COG3883	PFAM NLP P60 protein
O6U12_20860	COG0492	ferredoxin-NADP+ reductase activity
O6U12_20865	COG1051	belongs to the nudix hydrolase family
O6U12_20870	COG1660	Displays ATPase and GTPase activities
O6U12_20875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O6U12_20880	COG1481	regulation of sporulation
O6U12_20885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O6U12_20890	COG2162	N-hydroxyarylamine O-acetyltransferase activity
O6U12_20900	COG0745	RESPONSE REGULATOR receiver
O6U12_20905	COG5002	protein histidine kinase activity
O6U12_20910	COG1136	(ABC) transporter
O6U12_20915	COG0577	efflux transmembrane transporter activity
O6U12_20920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O6U12_20925	COG0288	reversible hydration of carbon dioxide
O6U12_20930	COG0659	secondary active sulfate transmembrane transporter activity
O6U12_20935	COG1694	Mazg nucleotide pyrophosphohydrolase
O6U12_20940	COG1611	Belongs to the LOG family
O6U12_20945	COG1609	Transcriptional regulator
O6U12_20950	COG0366	Alpha amylase catalytic
O6U12_20955	COG2182	Extracellular solute-binding protein
O6U12_20960	COG1175	transmembrane transport
O6U12_20965	COG3833	ABC-type maltose transport systems, permease component
O6U12_20970	COG5521	maltodextrose utilization protein MalA
O6U12_20975	COG1554	hydrolase, family 65, central catalytic
O6U12_20980	COG0366	Alpha amylase catalytic
O6U12_20985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O6U12_20990	COG0740	serine-type endopeptidase activity
O6U12_21005	COG2076	Multidrug Resistance protein
O6U12_21010	COG2076	Multidrug Resistance protein
O6U12_21015	COG1309	transcriptional regulator
O6U12_21020	COG0531	amino acid
O6U12_21025	COG1621	beta-fructofuranosidase activity
O6U12_21030	COG1621	beta-fructofuranosidase activity
O6U12_21035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O6U12_21040	COG1794	racemase activity, acting on amino acids and derivatives
O6U12_21050	COG3479	Phenolic acid decarboxylase
O6U12_21060	COG2272	Belongs to the type-B carboxylesterase lipase family
O6U12_21065	COG1396	sequence-specific DNA binding
O6U12_21070	COG3944	biosynthesis protein
O6U12_21075	COG0489	protein tyrosine kinase activity
O6U12_21080	COG1086	Polysaccharide biosynthesis protein
O6U12_21085	COG0438	transferase activity, transferring glycosyl groups
O6U12_21090	COG1215	transferase activity, transferring glycosyl groups
O6U12_21095	COG0438	transferase activity, transferring glycosyl groups
O6U12_21105	COG1216	Glycosyl transferase, family 2
O6U12_21110	COG5039	Polysaccharide pyruvyl transferase
O6U12_21115	COG1216	Glycosyl transferase, family 2
O6U12_21120	COG2244	polysaccharide biosynthetic process
O6U12_21125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O6U12_21130	COG0110	maltose O-acetyltransferase activity
O6U12_21135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O6U12_21140	COG5039	Polysaccharide pyruvyl transferase
O6U12_21150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O6U12_21155	COG1620	l-lactate permease
O6U12_21160	COG2186	Transcriptional regulator
O6U12_21165	COG1609	Transcriptional regulator
O6U12_21170	COG2182	Extracellular solute-binding protein
O6U12_21175	COG1175	transmembrane transport
O6U12_21180	COG3833	ABC-type maltose transport systems, permease component
O6U12_21185	COG1874	Beta-galactosidase
O6U12_21190	COG3867	Arabinogalactan endo-beta-1,4-galactanase
O6U12_21195	COG2208	phosphoserine phosphatase activity
O6U12_21200	COG0596	Alpha beta hydrolase
O6U12_21205	COG1131	(ABC) transporter
O6U12_21210	COG0842	Transport permease protein
O6U12_21215	COG4585	Histidine kinase
O6U12_21220	COG2197	response regulator
O6U12_21235	COG0247	lactate metabolic process
O6U12_21240	COG1139	Iron-sulfur cluster binding protein
O6U12_21245	COG1556	Lactate utilization protein
O6U12_21250	COG3858	chitin binding
O6U12_21255	COG1113	amino acid transport
O6U12_21260	COG0697	spore germination
O6U12_21265	COG0583	DNA-binding transcription factor activity
O6U12_21270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O6U12_21275	COG1609	Transcriptional regulator
O6U12_21280	COG2814	Major facilitator Superfamily
O6U12_21285	COG2390	Transcriptional regulator
O6U12_21290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O6U12_21295	COG0126	phosphoglycerate kinase activity
O6U12_21300	COG0149	triose-phosphate isomerase activity
O6U12_21305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O6U12_21310	COG0148	phosphopyruvate hydratase activity
O6U12_21315	COG0456	acetyltransferase
O6U12_21325	COG3064	Membrane
O6U12_21335	COG2095	MarC family integral membrane protein
O6U12_21340	COG1510	regulation of RNA biosynthetic process
O6U12_21345	COG0517	IMP dehydrogenase activity
O6U12_21345	COG1125	glycine betaine transport
O6U12_21350	COG1174	glycine betaine transport
O6U12_21355	COG1732	Glycine betaine
O6U12_21360	COG1174	glycine betaine transport
O6U12_21365	COG0640	Transcriptional regulator
O6U12_21370	COG5658	integral membrane protein
O6U12_21390	COG1510	regulation of RNA biosynthetic process
O6U12_21395	COG1125	glycine betaine transport
O6U12_21395	COG0517	IMP dehydrogenase activity
O6U12_21400	COG1174	glycine betaine transport
O6U12_21405	COG1732	Glycine betaine
O6U12_21410	COG1174	glycine betaine transport
O6U12_21415	COG0840	transmembrane signaling receptor activity
O6U12_21425	COG1733	regulation of RNA biosynthetic process
O6U12_21430	COG1396	sequence-specific DNA binding
O6U12_21435	COG1396	sequence-specific DNA binding
O6U12_21440	COG1476	TRANSCRIPTIONal
O6U12_21445	COG0596	Alpha beta hydrolase
O6U12_21450	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O6U12_21455	COG1647	Serine aminopeptidase, S33
O6U12_21460	COG0557	exoribonuclease II activity
O6U12_21465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O6U12_21480	COG1309	transcriptional regulator
O6U12_21485	COG2076	Multidrug Resistance protein
O6U12_21495	COG1289	transmembrane transporter activity
O6U12_21500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O6U12_21505	COG0673	inositol 2-dehydrogenase activity
O6U12_21510	COG1937	Protein conserved in bacteria
O6U12_21515	COG2608	mercury ion transmembrane transporter activity
O6U12_21520	COG2217	Heavy metal translocating P-type atpase
O6U12_21525	COG2217	Heavy metal translocating P-type atpase
O6U12_21530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O6U12_21535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O6U12_21540	COG2860	membrane
O6U12_21545	COG3973	AAA domain
O6U12_21550	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O6U12_21555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O6U12_21560	COG0025	NhaP-type Na H and K H
O6U12_21570	COG0656	L-ascorbic acid biosynthetic process
O6U12_21575	COG4149	molybdate abc transporter
O6U12_21580	COG0725	ABC transporter, periplasmic molybdate-binding protein
O6U12_21585	COG1910	domain protein
O6U12_21590	COG1368	sulfuric ester hydrolase activity
O6U12_21595	COG1988	membrane-bound metal-dependent
O6U12_21605	COG0531	amino acid
O6U12_21610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_21615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_21620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_21625	COG1120	ATPase activity
O6U12_21630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O6U12_21635	COG1136	(ABC) transporter
O6U12_21640	COG0577	efflux transmembrane transporter activity
O6U12_21650	COG2140	Oxalate decarboxylase
O6U12_21660	COG1191	sigma factor activity
O6U12_21670	COG0745	RESPONSE REGULATOR receiver
O6U12_21675	COG2205	protein histidine kinase activity
O6U12_21680	COG3386	PFAM SMP-30 Gluconolaconase
O6U12_21685	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_21690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O6U12_21695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O6U12_21700	COG1120	ATPase activity
O6U12_21705	COG2096	Adenosyltransferase
O6U12_21710	COG2814	Major facilitator Superfamily
O6U12_21715	COG4758	membrane
O6U12_21720	COG1842	Phage shock protein A
O6U12_21730	COG4758	membrane
O6U12_21735	COG4585	Histidine kinase
O6U12_21740	COG2197	response regulator
O6U12_21750	COG0814	amino acid
O6U12_21755	COG0697	spore germination
O6U12_21765	COG0114	fumarate hydratase activity
O6U12_21770	COG1309	transcriptional regulator
O6U12_21780	COG2770	Histidine kinase
O6U12_21780	COG2205	protein histidine kinase activity
O6U12_21785	COG0745	RESPONSE REGULATOR receiver
O6U12_21790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O6U12_21795	COG0783	Belongs to the Dps family
O6U12_21800	COG1028	Short-chain dehydrogenase reductase Sdr
O6U12_21815	COG1120	ATPase activity
O6U12_21825	COG3328	transposase activity
O6U12_21830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O6U12_21865	COG1942	4-Oxalocrotonate Tautomerase
O6U12_21870	COG0477	Major facilitator Superfamily
O6U12_21875	COG1846	Transcriptional regulator
O6U12_21880	COG5577	PFAM Coat F domain
O6U12_21890	COG0506	proline dehydrogenase activity
O6U12_21900	COG1250	3-hydroxyacyl-CoA dehydrogenase
O6U12_21900	COG1024	Enoyl-CoA hydratase
O6U12_21905	COG0183	Belongs to the thiolase family
O6U12_21910	COG1960	acyl-CoA dehydrogenase activity
O6U12_21915	COG1393	Belongs to the ArsC family
O6U12_21920	COG0509	glycine decarboxylation via glycine cleavage system
O6U12_21930	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O6U12_21935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O6U12_21945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O6U12_21950	COG2011	ABC-type metal ion transport system permease component
O6U12_21955	COG1464	Belongs to the NlpA lipoprotein family
O6U12_21970	COG0396	ATPase activity
O6U12_21975	COG0719	Fe-S assembly protein
O6U12_21980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O6U12_21985	COG0822	iron-sulfur transferase activity
O6U12_21990	COG0719	Fe-S assembly protein
O6U12_21995	COG4974	Belongs to the 'phage' integrase family
O6U12_22035	COG3646	Phage regulatory protein
O6U12_22035	COG3645	SOS response
O6U12_22065	COG0305	Participates in initiation and elongation during chromosome replication
O6U12_22080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O6U12_22095	COG2337	Toxic component of a toxin-antitoxin (TA) module
O6U12_22135	COG0740	serine-type endopeptidase activity
O6U12_22230	COG5632	N-Acetylmuramoyl-L-alanine amidase
O6U12_22230	COG3409	Peptidoglycan-binding domain 1 protein
O6U12_22230	COG1388	LysM domain
O6U12_22300	COG3883	PFAM NLP P60 protein
O6U12_22300	COG0791	NLP P60 protein
O6U12_22315	COG3209	COG3209 Rhs family protein
O6U12_22365	COG2003	Belongs to the UPF0758 family
O6U12_22395	COG1988	membrane-bound metal-dependent
O6U12_22410	COG2002	toxin-antitoxin pair type II binding
O6U12_22505	COG3764	Sortase (surface protein transpeptidase)
O6U12_22540	COG0457	Tetratricopeptide repeat