locus-tag class description BS11774_00010 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BS11774_00020 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BS11774_00150 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BS11774_00155 ENOG4105VRR gCN5-related N-acetyltransferase BS11774_00160 ENOG4105DZ6 Band 7 protein BS11774_00170 ENOG4106DF1 BS11774_00175 ENOG4108VNY MOSC domain protein BS11774_00180 ENOG4108JB8 alcohol dehydrogenase BS11774_00185 ENOG4105C26 Dehydrogenase BS11774_00190 ENOG4105TRT Transcriptional regulator BS11774_00210 ENOG4105CZN Potassium uptake protein BS11774_00215 ENOG4107I77 yiaA/B two helix domain BS11774_00220 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BS11774_00240 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BS11774_00250 ENOG4105EE0 oxidoreductase BS11774_00255 ENOG4105DKG l-rhamnose isomerase BS11774_00260 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) BS11774_00265 ENOG4105DET Rhamnulokinase BS11774_00270 ENOG4105E98 transcriptional regulator DeoR family BS11774_00285 ENOG4105C8Q Methyl-accepting chemotaxis BS11774_00290 ENOG4105C8Q Methyl-accepting chemotaxis BS11774_00295 ENOG4105C8Q Methyl-accepting chemotaxis BS11774_00300 ENOG4105C8Q Methyl-accepting chemotaxis BS11774_00315 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BS11774_00325 ENOG4105C37 (CBS) domain BS11774_00340 ENOG4107PBV potassium channel BS11774_00345 ENOG4107PBV potassium channel BS11774_00360 ENOG4107QYV phosphohexose isomerase BS11774_00370 ENOG4107QW4 alcohol dehydrogenase BS11774_00375 ENOG4105WG9 Conserved Protein BS11774_00385 ENOG4105CHM Aminotransferase BS11774_00390 ENOG4108ZB6 transcriptional regulator AsnC family BS11774_00395 ENOG4108MUZ hydrolase BS11774_00405 ENOG4105C87 Aminotransferase class I and II BS11774_00410 ENOG4108HGU Histidine kinase BS11774_00415 ENOG4105Y38 Kinase-associated protein B BS11774_00435 ENOG4105BZ4 penicillin-binding protein BS11774_00440 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BS11774_00455 ENOG4108MRH transcriptional regulatory protein BS11774_00460 ENOG4105DIH basic membrane BS11774_00465 ENOG4108JQ9 ABC transporter BS11774_00470 ENOG4105UIB (ABC) transporter BS11774_00490 ENOG4105D65 subunit l BS11774_00495 ENOG4105HC0 Na H antiporter BS11774_00500 ENOG4108ZE9 Monovalent cation H antiporter subunit C BS11774_00505 ENOG4108JPZ Monovalent cation H antiporter subunit D BS11774_00510 ENOG4105SC1 monovalent cation H antiporter subunit E BS11774_00520 ENOG4105KJM monovalent cation h antiporter subunit g BS11774_00525 ENOG4105KA0 thioesterase Superfamily protein BS11774_00575 ENOG4105D58 Diguanylate phosphodiesterase BS11774_00580 ENOG4105DAP Nicotinate phosphoribosyltransferase BS11774_00605 ENOG4105C02 permease BS11774_00625 ENOG410904N short-chain dehydrogenase reductase BS11774_00660 ENOG4108K8K Transcriptional regulator BS11774_00665 ENOG4105DCF alanine dehydrogenase BS11774_00680 ENOG4105WQT MbtH domain protein BS11774_00685 ENOG4105CEY Amp-dependent synthetase and ligase BS11774_00690 ENOG4105WQI isochorismatase BS11774_00695 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BS11774_00700 ENOG4105E4F Isochorismate synthase BS11774_00705 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BS11774_00710 ENOG4105NIV Esterase BS11774_00730 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BS11774_00740 ENOG41069ER domain protein BS11774_00755 ENOG4105CEP NADH dehydrogenase BS11774_00760 ENOG4105CAY ferredoxin--nadp reductase BS11774_00780 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BS11774_00785 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BS11774_00800 ENOG4105ZKE UPF0349 protein BS11774_00815 ENOG41083MR nifu domain-containing protein BS11774_00820 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BS11774_00825 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BS11774_00830 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BS11774_00835 ENOG4105D6E homoserine dehydrogenase BS11774_00845 ENOG4108W5N phosphatidylglycerophosphatase a BS11774_00850 ENOG4105D4U had-superfamily hydrolase, subfamily iia BS11774_00860 ENOG4105MMD transcriptional regulator BS11774_00865 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BS11774_00870 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BS11774_00875 ENOG4105FAA peptidase M23 BS11774_00880 ENOG4108YTE sporulation protein YunB BS11774_00885 ENOG4105KZD Domain of unknown function (DUF1805) BS11774_00890 ENOG4107R8B 5'-nucleotidase BS11774_00900 ENOG4105I3N Conserved Protein BS11774_00910 ENOG4105CD3 dihydroorotase BS11774_00915 ENOG4105G9B Transcriptional regulator BS11774_00930 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) BS11774_00935 ENOG4105VT2 5-hydroxyisourate hydrolase BS11774_00945 ENOG4107YV9 domain protein BS11774_00950 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BS11774_00965 ENOG4105XRQ Xanthine dehydrogenase accessory factor BS11774_00970 ENOG4105C5R Aminotransferase BS11774_00980 ENOG4108K8S endonuclease I BS11774_00985 ENOG4108IJ9 (ABC) transporter BS11774_00990 ENOG4105FDP GntR family transcriptional regulator BS11774_00995 ENOG4108KPW sugar kinase BS11774_01000 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BS11774_01005 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BS11774_01010 ENOG4105XN3 extracellular solute-binding protein family 1 BS11774_01015 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BS11774_01020 ENOG4105PKS Excinuclease abc c subunit domain protein BS11774_01025 ENOG4107VFR oxidoreductase BS11774_01045 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BS11774_01050 ENOG4105NPE arsR family transcriptional regulator BS11774_01095 ENOG41068G1 BS11774_01100 ENOG410651K Teichoic acid biosynthesis protein C BS11774_01165 ENOG4105CDU Replicative dna helicase BS11774_01190 ENOG4108ZUE Phage regulatory protein rha BS11774_01250 ENOG4105DIW FeS assembly protein SUFB BS11774_01255 ENOG4108UNV SUF system FeS assembly protein, NifU family BS11774_01260 ENOG4105C9B Cysteine desulfurase BS11774_01265 ENOG4105JRK feS assembly protein SufD BS11774_01270 ENOG4105C3K feS assembly ATPase SufC BS11774_01290 ENOG4105D01 (LipO)protein BS11774_01295 ENOG4108UMI ABC transporter, permease BS11774_01300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BS11774_01325 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BS11774_01330 ENOG41080E8 Transcriptional regulator, Spx MgsR family BS11774_01335 ENOG4105C1G acyl-Coa dehydrogenase BS11774_01340 ENOG4105CHU acetyl-coa acetyltransferase BS11774_01370 ENOG41067TZ transcriptional regulator, MarR family BS11774_01375 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS11774_01380 ENOG4105MDS 4-oxalocrotonate tautomerase BS11774_01390 ENOG4105EGI Transcriptional regulator BS11774_01400 ENOG4105E0A ABC, transporter BS11774_01415 ENOG4105E1F short-chain dehydrogenase reductase BS11774_01420 ENOG4105HUF DNA protection during starvation protein BS11774_01425 ENOG4105C0H protease BS11774_01435 ENOG4105F3H Histidine kinase BS11774_01445 ENOG41067SE Tetr family transcriptional regulator BS11774_01450 ENOG4105C9Q fumarate hydratase class II BS11774_01475 ENOG4105WH1 Two component transcriptional regulator luxr family BS11774_01480 ENOG4105ENE Histidine kinase BS11774_01495 ENOG41087YS Phage shock protein A BS11774_01510 ENOG4108WBT adenosyltransferase BS11774_01515 ENOG4105E0A ABC, transporter BS11774_01520 ENOG4105EHG Permease protein BS11774_01525 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BS11774_01530 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BS11774_01535 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BS11774_01545 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS11774_01555 ENOG4106DF4 Sigma-70, region 4 BS11774_01565 ENOG4105F0F Oxalate decarboxylase BS11774_01575 ENOG4107RBB ABC transporter, permease BS11774_01580 ENOG4105C19 ABC transporter BS11774_01585 ENOG4108WMK Efflux transporter RND family MFP subunit BS11774_01590 ENOG4105E0A ABC, transporter BS11774_01595 ENOG4105EHG Permease protein BS11774_01600 ENOG4105DQ5 transport system permease protein BS11774_01615 ENOG4105D5Q Arginine ornithine antiporter BS11774_01630 ENOG4107K5X Membrane-bound metal-dependent hydrolase BS11774_01635 ENOG4107QZ2 Sulfatase BS11774_01640 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BS11774_01645 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BS11774_01650 ENOG4105E0C molybdate abc transporter BS11774_01665 ENOG4105EEQ Na H antiporter BS11774_01670 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BS11774_01675 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BS11774_01680 ENOG4105EEM helicase BS11774_01685 ENOG4105EN6 Membrane BS11774_01695 ENOG4107ZQN disulfide bond BS11774_01700 ENOG4105C59 p-type ATPase BS11774_01705 ENOG4105C59 p-type ATPase BS11774_01710 ENOG410681U heavy metal transport detoxification protein BS11774_01715 ENOG4105VPX protein, conserved in bacteria BS11774_01720 ENOG4105D9R oxidoreductase BS11774_01725 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BS11774_01730 ENOG4105ME7 Membrane BS11774_01735 ENOG4105RXJ BS11774_01745 ENOG4105KBX Transcriptional regulator, TetR family BS11774_01750 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BS11774_01760 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BS11774_01765 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BS11774_01775 ENOG4105XZU Preprotein translocase, subunit SecG BS11774_01800 ENOG4105KVH Transcriptional regulator BS11774_01805 ENOG4105C8Q Methyl-accepting chemotaxis BS11774_01810 ENOG4105R40 Glycine betaine carnitine choline BS11774_01815 ENOG4108HQR Glycine betaine BS11774_01820 ENOG4105E90 ABC transporter BS11774_01825 ENOG4108IJ8 ABC transporter BS11774_01830 ENOG4107HG4 Transcriptional regulator BS11774_01835 ENOG4105R40 Glycine betaine carnitine choline BS11774_01840 ENOG4108HQR Glycine betaine BS11774_01845 ENOG4105E90 ABC transporter BS11774_01850 ENOG4108IJ8 ABC transporter BS11774_01855 ENOG4107HG4 Transcriptional regulator BS11774_01860 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BS11774_01875 ENOG4105T65 Membrane-associated protein BS11774_01880 ENOG4108W0I acetyltransferase BS11774_01890 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BS11774_01895 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BS11774_01900 ENOG4105CP7 Triose-phosphate isomerase BS11774_01905 ENOG4105BZA Phosphoglycerate kinase BS11774_01910 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BS11774_01925 ENOG4105CMD Transcriptional regulator, GntR family BS11774_01930 ENOG4105DEN Luciferase family BS11774_01940 ENOG4105GZI Transcriptional regulator BS11774_01945 ENOG4107RT3 EamA-like transporter family BS11774_01955 ENOG4105VRS hydrolase family 18 BS11774_01960 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BS11774_01965 ENOG4107QR9 Iron-sulfur cluster binding protein BS11774_01970 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BS11774_01980 ENOG4105BZU Histidine kinase BS11774_01985 ENOG4105KCT ABC transporter BS11774_01990 ENOG4108M15 ABC transporter BS11774_01995 ENOG4107R6F Alpha Beta Hydrolase Fold protein BS11774_02000 ENOG4108MJI response regulator BS11774_02015 ENOG4105EG2 ABC transporter, permease BS11774_02025 ENOG4107FKK extracellular solute-binding protein family 1 BS11774_02035 ENOG4105JXH GntR family transcriptional regulator BS11774_02040 ENOG4105DAA L-lactate BS11774_02045 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS11774_02055 ENOG4108ZPC Polysaccharide pyruvyl transferase BS11774_02060 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BS11774_02065 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BS11774_02070 ENOG4105D3Q Sugar transferase BS11774_02080 ENOG4105K64 Glycosyl transferase, family 2 BS11774_02090 ENOG4107QRS glycosyltransferase group 2 family protein BS11774_02095 ENOG41068W6 Capsular polysaccharide biosynthesis protein BS11774_02100 ENOG4108KMV Glycosyl transferase (Group 1 BS11774_02105 ENOG4105K64 Glycosyl transferase, family 2 BS11774_02120 ENOG4108QV3 biosynthesis protein BS11774_02125 ENOG4105HTX biosynthesis protein BS11774_02135 ENOG4105EBR Carboxylesterase BS11774_02145 ENOG4105PY6 Phenolic acid decarboxylase BS11774_02150 ENOG4105NI3 Protein of unknown function (DUF3237) BS11774_02160 ENOG4105FQP Beta-lactamase BS11774_02165 ENOG4105EDQ levansucrase EC 2.4.1.10 BS11774_02170 ENOG4108HKT sucrose-6-phosphate hydrolase BS11774_02175 ENOG4107QTZ amino acid BS11774_02205 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BS11774_02210 ENOG4107URF beta-phospho-glucomutase BS11774_02215 ENOG4105CG3 alpha amylase, catalytic region BS11774_02230 ENOG4105EG2 ABC transporter, permease BS11774_02235 ENOG4105D56 permease protein BS11774_02240 ENOG4107FKK extracellular solute-binding protein family 1 BS11774_02245 ENOG4108IUK alpha amylase, catalytic BS11774_02250 ENOG4105FKQ transcriptional regulator BS11774_02255 ENOG4108URH decarboxylase BS11774_02260 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BS11774_02265 ENOG4105CHH sulfate transporter BS11774_02270 ENOG4108V2W Carbonate dehydratase BS11774_02280 ENOG4105C5I Dehydrogenase BS11774_02290 ENOG4105C19 ABC transporter BS11774_02295 ENOG4105EWM Histidine kinase BS11774_02305 ENOG4107A6P BS11774_02310 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BS11774_02315 ENOG4105KRI phosphocarrier protein (HPr BS11774_02320 ENOG4105CIE May be required for sporulation (By similarity) BS11774_02325 ENOG4105CHW UPF0052 protein BS11774_02330 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BS11774_02335 ENOG4108Z4K mutator MutT protein BS11774_02340 ENOG4105C3M thioredoxin reductase BS11774_02355 ENOG4105BZ1 (ABC) transporter BS11774_02365 ENOG4106FGC BS11774_02375 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BS11774_02380 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BS11774_02385 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BS11774_02390 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BS11774_02395 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BS11774_02400 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BS11774_02405 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BS11774_02410 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BS11774_02420 ENOG4108E16 pectate lyase BS11774_02425 ENOG4108S4C acetyltransferase BS11774_02430 ENOG4107XGZ Hydrolase BS11774_02435 ENOG4105HKU nucleoside recognition domain-containing protein BS11774_02440 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BS11774_02445 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BS11774_02450 ENOG4105CE4 GlcNAc 6-P deacetylase BS11774_02455 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BS11774_02460 ENOG4105FDP GntR family transcriptional regulator BS11774_02465 ENOG41088CQ domain protein BS11774_02470 ENOG41086DT Membrane protein of unknown function BS11774_02475 ENOG41067S9 phage shock protein C, PspC BS11774_02480 ENOG4108PY7 BS11774_02495 ENOG4105I03 Flagellin BS11774_02500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BS11774_02505 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BS11774_02520 ENOG4105MKU Transcriptional regulator BS11774_02540 ENOG4105CN1 protease BS11774_02545 ENOG4105CRP Part of the ABC transporter FtsEX involved in BS11774_02550 ENOG4105CAK Cell division ATP-binding protein ftsE BS11774_02575 ENOG4105MS2 ribosomal subunit Interface protein BS11774_02590 ENOG4105MQ3 flagellar protein FliS BS11774_02595 ENOG4107RT6 flagellar hook-associated BS11774_02600 ENOG41083S7 flagellar protein FlaG BS11774_02605 ENOG4105I03 Flagellin BS11774_02610 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BS11774_02615 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BS11774_02620 ENOG4105MKD BS11774_02625 ENOG4105DTJ flagellar hook-associated protein BS11774_02630 ENOG4105E1Q flagellar hook-associated protein BS11774_02645 ENOG4105RU3 BS11774_02650 ENOG41081UC Inherit from COG: Competence protein BS11774_02670 ENOG4105WH1 Two component transcriptional regulator luxr family BS11774_02675 ENOG4105BZU Histidine kinase BS11774_02680 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BS11774_02685 ENOG4108KGH TRANSCRIPTIONal BS11774_02690 ENOG4105ESV Glycosyl transferase, family 4 BS11774_02695 ENOG4107EF8 Glycosyl transferase (Group 1 BS11774_02710 ENOG4105QZI O-Antigen Polymerase BS11774_02715 ENOG4105C6Y Udp-glucose 6-dehydrogenase BS11774_02720 ENOG4107RA4 Glycosyl transferase (Group 1 BS11774_02725 ENOG4105PSV Polysaccharide Biosynthesis Protein BS11774_02730 ENOG4105D3Q Sugar transferase BS11774_02740 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS11774_02745 ENOG4105JFG SpoIID LytB domain protein BS11774_02760 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BS11774_02780 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS11774_02785 ENOG4105EY8 ABC transporter BS11774_02805 ENOG4107VDP teichoic acid biosynthesis BS11774_02810 ENOG41088M2 Glycosyl transferase family 2 BS11774_02860 ENOG4105DG6 mannose-6-phosphate isomerase BS11774_02875 ENOG4108NHD germination protein BS11774_02880 ENOG4105C54 Major Facilitator superfamily BS11774_02885 ENOG4108KGH TRANSCRIPTIONal BS11774_02890 ENOG4105J7I hydrolase BS11774_02900 ENOG4105K4H Nlp p60 protein BS11774_02910 ENOG4105PNM synthesis protein BS11774_02920 ENOG4105N98 Capsule biosynthesis protein capB BS11774_02925 ENOG4105ETE Transcriptional regulator (LacI family BS11774_02930 ENOG4108RVA ribokinase BS11774_02935 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BS11774_02940 ENOG4105C2J ABC transporter BS11774_02945 ENOG4105CNN ABC, transporter BS11774_02950 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BS11774_02965 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BS11774_02970 ENOG4107FQX Alpha-acetolactate decarboxylase BS11774_02980 ENOG4107RSM transcriptional regulator BS11774_02995 ENOG4106UIA BS11774_03010 ENOG4107XC4 flavin reductase domain protein, FMN-binding BS11774_03020 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BS11774_03030 ENOG4105CAH Chromate BS11774_03035 ENOG4105FGV Chromate BS11774_03045 ENOG4108WS4 fmn reductase BS11774_03050 ENOG4107V2S Transcriptional regulator BS11774_03055 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BS11774_03080 ENOG4108XI2 Domain of unknown function (DUF1963) BS11774_03085 ENOG4105C6Y Udp-glucose 6-dehydrogenase BS11774_03090 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BS11774_03095 ENOG4107YJ4 chain length determinant protein BS11774_03100 ENOG4105HTX biosynthesis protein BS11774_03115 ENOG4105KBK Zinc finger, swim domain protein BS11774_03120 ENOG4105C0D helicase BS11774_03130 ENOG410667J hydrolase BS11774_03135 ENOG4105E98 transcriptional regulator DeoR family BS11774_03140 ENOG4105Z8H single-stranded DNA-binding protein BS11774_03165 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BS11774_03170 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BS11774_03180 ENOG4105CGA flagellar basal-body rod protein FlgG BS11774_03190 ENOG4105DFF Rod shape-determining protein mreb BS11774_03195 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BS11774_03205 ENOG4107MII Sugar-specific transcriptional regulator TrmB BS11774_03210 ENOG4105CZM Major Facilitator BS11774_03215 ENOG4108M26 parallel beta-helix repeat protein BS11774_03220 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BS11774_03225 ENOG41080V3 Major Facilitator superfamily BS11774_03230 ENOG4105D3W isochorismatase BS11774_03235 ENOG4107P26 BS11774_03240 ENOG4105BZU Histidine kinase BS11774_03250 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BS11774_03260 ENOG4105FRN stage II sporulation protein BS11774_03265 ENOG4107TCE N-acetyltransferase BS11774_03280 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS11774_03285 ENOG4107TXC Transcriptional regulator BS11774_03290 ENOG4106BRK BS11774_03295 ENOG4108RYK Nad-dependent epimerase dehydratase BS11774_03300 ENOG4108Z40 Transcriptional regulator BS11774_03305 ENOG4105CQM Urea amidohydrolase subunit alpha BS11774_03310 ENOG4105KI2 Urea amidohydrolase subunit beta BS11774_03315 ENOG4108YZ9 Urea amidohydrolase subunit gamma BS11774_03355 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BS11774_03365 ENOG4108TF4 von Willebrand factor, type A BS11774_03380 ENOG4105JFG SpoIID LytB domain protein BS11774_03385 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BS11774_03395 ENOG4106778 Protein of unknown function (DUF1146) BS11774_03405 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BS11774_03410 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BS11774_03415 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BS11774_03420 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BS11774_03440 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) BS11774_03450 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BS11774_03455 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BS11774_03460 ENOG4108UIC UPF0340 protein BS11774_03465 ENOG4108YZG isomerase BS11774_03470 ENOG4107WAU Protein tyrosine phosphatase BS11774_03475 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BS11774_03480 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BS11774_03490 ENOG4108ZXQ stage ii sporulation protein r BS11774_03505 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BS11774_03510 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BS11774_03515 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BS11774_03525 ENOG4107TT2 Auxin Efflux Carrier BS11774_03530 ENOG4105C6K Malic enzyme BS11774_03535 ENOG4107104 thymidine kinase BS11774_03540 ENOG41082DI 50s ribosomal protein l31 BS11774_03545 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BS11774_03550 ENOG4105CBT Fructose-1,6-bisphosphatase BS11774_03555 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BS11774_03560 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway BS11774_03565 ENOG4105D2N Aldolase BS11774_03570 ENOG410812K response regulator receiver protein BS11774_03585 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BS11774_03595 ENOG4105C1G acyl-Coa dehydrogenase BS11774_03600 ENOG4105DF6 Fe-S oxidoreductase BS11774_03610 ENOG4105E5J UV damage endonuclease BS11774_03620 ENOG4105NAE bifunctional deaminase-reductase domain protein BS11774_03625 ENOG4105BZ1 (ABC) transporter BS11774_03645 ENOG4105R3A Nitrate reductase BS11774_03650 ENOG4108IUE nitrate reductase beta subunit BS11774_03670 ENOG4107V6Q Cyclic nucleotide-binding domain BS11774_03680 ENOG4105C75 arginyL-tRNA synthetase BS11774_03685 ENOG410684U Domain of unknown function (DUF1934) BS11774_03700 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E BS11774_03750 ENOG4107JM4 Tetratricopeptide repeat BS11774_03765 ENOG4105CYW agmatinase BS11774_03770 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BS11774_03775 ENOG4105BZ4 penicillin-binding protein BS11774_03785 ENOG4108XFG YwhD family BS11774_03790 ENOG4108Z4T Peptidase M50 BS11774_03795 ENOG41069HH 4-oxalocrotonate tautomerase BS11774_03800 ENOG41067TZ transcriptional regulator, MarR family BS11774_03805 ENOG4105C22 threonyL-tRNA synthetase BS11774_03815 ENOG4105C57 major facilitator superfamily BS11774_03820 ENOG41062ES Transcriptional regulator BS11774_03830 ENOG4105DCI Phosphohydrolase BS11774_03840 ENOG4108VCI transcription factor, rsfa family BS11774_03845 ENOG4108RNG Permease of the drug metabolite transporter BS11774_03850 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BS11774_03855 ENOG4105DUM transcriptional regulator, lysR family BS11774_03860 ENOG4108IJ2 phosphate acetyltransferase BS11774_03885 ENOG4105CHR reductase BS11774_03890 ENOG4106CHD Bacilysin biosynthesis protein bacB BS11774_03895 ENOG41061WN bacilysin biosynthesis protein BS11774_03900 ENOG4105FCW Major Facilitator superfamily BS11774_03915 ENOG4105C26 Dehydrogenase BS11774_03920 ENOG4105D82 Glutamate dehydrogenase BS11774_03930 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BS11774_03935 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BS11774_03940 ENOG4105C1B dTDP-glucose 4-6-dehydratase BS11774_03945 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BS11774_03950 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BS11774_03955 ENOG4107TY6 Acylneuraminate cytidylyltransferase BS11774_03965 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BS11774_03970 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BS11774_04010 ENOG4105C26 Dehydrogenase BS11774_04015 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BS11774_04020 ENOG4108RJ9 Glycosyl transferase, family 2 BS11774_04040 ENOG4105DWF phosphomethylpyrimidine kinase BS11774_04060 ENOG4108QTI )-transporter BS11774_04075 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BS11774_04080 ENOG4105DEN Luciferase family BS11774_04085 ENOG4108DBC nitroreductase BS11774_04100 ENOG41060D1 Quinol oxidase BS11774_04105 ENOG4105CCU oxidase (Subunit III) BS11774_04110 ENOG4105BZ9 Cytochrome C oxidase, subunit I BS11774_04115 ENOG4105E2S oxidase) subunit II BS11774_04120 ENOG4107BMA Transglycosylase associated protein BS11774_04130 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BS11774_04135 ENOG4105WH5 Teichoic acid glycosylation protein BS11774_04160 ENOG4107ZXU DSBA oxidoreductase BS11774_04165 ENOG4105DBE peroxidase BS11774_04170 ENOG410650H (LipO)protein BS11774_04175 ENOG4107SJW iron permease, FTR1 BS11774_04185 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BS11774_04195 ENOG4105CMU LysR family (Transcriptional regulator BS11774_04200 ENOG4105VAW lrga family BS11774_04205 ENOG41067MG lrgb family BS11774_04210 ENOG4105D8G Major Facilitator superfamily BS11774_04220 ENOG4105DR4 Methyltransferase BS11774_04230 ENOG4108YV3 Protein of unknown function (DUF2711) BS11774_04235 ENOG4105CK1 PTS System BS11774_04240 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BS11774_04255 ENOG4105X1N Glycosyl transferase family 8 BS11774_04265 ENOG4105GVJ transcriptional regulator BS11774_04270 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BS11774_04290 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BS11774_04305 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BS11774_04310 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BS11774_04320 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BS11774_04325 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BS11774_04330 ENOG4105CM2 brancheD-chain amino acid aminotransferase BS11774_04335 ENOG4105F8D glycoside hydrolase family 4 BS11774_04340 ENOG4105VCP PTS System BS11774_04345 ENOG4105CK1 PTS System BS11774_04350 ENOG4105VZJ PTS System BS11774_04355 ENOG4105EMD TRANSCRIPTIONal BS11774_04365 ENOG4108VX5 3-methyladenine DNA glycosylase BS11774_04370 ENOG4105CH6 catalase BS11774_04385 ENOG4105DA5 (ABC) transporter BS11774_04390 ENOG41069JR BS11774_04410 ENOG4105ETS cytosine purines uracil thiamine allantoin BS11774_04415 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BS11774_04420 ENOG4108JJ8 (ABC) transporter BS11774_04425 ENOG4108JJ9 ABC, transporter BS11774_04430 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BS11774_04435 ENOG4105C4M (Ubiquinol oxidase) subunit I BS11774_04440 ENOG4105D2K citrate carrier protein BS11774_04455 ENOG4107BJW polysaccharide deacetylase BS11774_04475 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BS11774_04485 ENOG4105CMR udp-glucose 4-epimerase BS11774_04495 ENOG4105BZU Histidine kinase BS11774_04500 ENOG4105WH1 Two component transcriptional regulator luxr family BS11774_04505 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BS11774_04530 ENOG4105DTD Dehydrogenase BS11774_04535 ENOG4108IIH CoA-transferase subunit B BS11774_04540 ENOG4105D6N CoA-transferase, subunit a BS11774_04545 ENOG4105CY2 Citrate transporter BS11774_04550 ENOG4105DHI Methyltransferase BS11774_04555 ENOG4105H67 Protein of unknown function (DUF421) BS11774_04560 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS11774_04570 ENOG4108QY0 Membrane BS11774_04585 ENOG4105CZ3 stage V sporulation protein ad BS11774_04590 ENOG41090VF Stage v sporulation protein ac BS11774_04610 ENOG4105WEF catalase BS11774_04665 ENOG4105D4T Citrate transporter BS11774_04670 ENOG4108RZ2 Glycoside hydrolase family 16 BS11774_04675 ENOG4105CID antiterminator BS11774_04685 ENOG4105DEU major facilitator superfamily BS11774_04690 ENOG4105C1J atp-dependent rna helicase BS11774_04695 ENOG4107TDE lipolytic protein G-D-S-L family BS11774_04750 ENOG4105CNA YD repeat protein BS11774_04760 ENOG4107YZX Universal stress protein BS11774_04765 ENOG4105CS2 ec 3.2.1.21 BS11774_04770 ENOG4105C5Y PTS System BS11774_04780 ENOG4107EV6 Inherit from COG: YD repeat protein BS11774_04815 ENOG4106Z5D Glycoside Hydrolase Family 43 BS11774_04825 ENOG4105C84 Histidine ammonia-lyase BS11774_04830 ENOG4105CGP Urocanate hydratase BS11774_04835 ENOG4105CI2 imidazolone-5-propionate hydrolase BS11774_04840 ENOG4107W25 arginase agmatinase formiminoglutamase BS11774_04850 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BS11774_04855 ENOG4105D9N nucleoside BS11774_04865 ENOG4107RHR regulatoR BS11774_04870 ENOG4108TM9 integral membrane protein BS11774_04875 ENOG4105ENY Ethanolamine utilization protein eutH BS11774_04880 ENOG4108PGP mmge prpd family protein BS11774_04885 ENOG4105CH2 amidohydrolase BS11774_04895 ENOG4108HW4 amino acid AbC transporter BS11774_04900 ENOG4105EAB amino acid AbC transporter BS11774_04905 ENOG4108XSB acetyltransferase, (GNAT) family BS11774_04910 ENOG4105CPU Monooxygenase BS11774_04920 ENOG4107QHE Choloylglycine hydrolase BS11774_04925 ENOG410667J hydrolase BS11774_04955 ENOG4108V5C ABC transporter BS11774_04985 ENOG4105D2N Aldolase BS11774_04990 ENOG4107TRN Xylose isomerase domain protein TIM barrel BS11774_04995 ENOG4105F0H myo-inositol catabolism protein BS11774_05000 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BS11774_05010 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BS11774_05015 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BS11774_05020 ENOG4105D7K pfkb domain protein BS11774_05030 ENOG4105C26 Dehydrogenase BS11774_05040 ENOG4105CPC Aldo Keto reductase BS11774_05055 ENOG4107QNK )-transporter BS11774_05060 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BS11774_05070 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BS11774_05075 ENOG4105ST3 Transcriptional regulator BS11774_05080 ENOG4105C26 Dehydrogenase BS11774_05090 ENOG4108ITS PQQ enzyme repeat BS11774_05100 ENOG41085PJ rdd domain containing protein BS11774_05115 ENOG4105J7D transcriptional regulator BS11774_05120 ENOG4107JEE Short-chain dehydrogenase reductase Sdr BS11774_05125 ENOG41061AU MarR family Transcriptional regulator BS11774_05135 ENOG41067MG lrgb family BS11774_05145 ENOG4105BZW Glycerate kinase BS11774_05150 ENOG4105G3Z GntR family transcriptional regulator BS11774_05155 ENOG4105CMG Carbohydrate kinase BS11774_05160 ENOG4105C6Z Gluconate BS11774_05165 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BS11774_05170 ENOG4105D3R alkyl hydroperoxide reductase BS11774_05175 ENOG4108JU3 Alkyl hydroperoxide reductase BS11774_05185 ENOG4105CS2 ec 3.2.1.21 BS11774_05195 ENOG4105C5Y PTS System BS11774_05200 ENOG4108S3Y transcriptional regulator BS11774_05210 ENOG4106KKU BS11774_05215 ENOG4108Z15 abc transporter atp-binding protein BS11774_05220 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BS11774_05235 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BS11774_05240 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BS11774_05255 ENOG4105E2A Dehydrogenase BS11774_05275 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BS11774_05285 ENOG410780I phosphoprotein phosphatase activity BS11774_05295 ENOG41066UZ arginase EC 3.5.3.1 BS11774_05300 ENOG4108IQI permease BS11774_05305 ENOG4105C8Y Acetylornithine aminotransferase BS11774_05310 ENOG4108JUB Transcriptional regulator BS11774_05315 ENOG4105BZU Histidine kinase BS11774_05335 ENOG4105C0H protease BS11774_05340 ENOG4105Q2H domain protein BS11774_05355 ENOG4105BZU Histidine kinase BS11774_05360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS11774_05385 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BS11774_05390 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BS11774_05395 ENOG4105CDU Replicative dna helicase BS11774_05420 ENOG4105EDW glycosyl transferase, family 39 BS11774_05425 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BS11774_05430 ENOG4105BZR domain protein BS11774_05435 ENOG4108XMW Membrane BS11774_05450 ENOG4105KVH Transcriptional regulator BS11774_05455 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BS11774_05475 ENOG41090E6 transcriptional regulator MERR family BS11774_05485 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein BS11774_05490 ENOG4105DDN Pentapeptide repeat-containing protein BS11774_05495 ENOG4105D94 Major Facilitator Superfamily BS11774_05500 ENOG4107RSM transcriptional regulator BS11774_05505 ENOG41082BV acetyltransferase BS11774_05510 ENOG41081I9 integral membrane protein BS11774_05525 ENOG4108U05 Transcriptional regulator BS11774_05530 ENOG41082BV acetyltransferase BS11774_05540 ENOG4108U7W acetyltransferase BS11774_05545 ENOG4105UNS Pfam:DUF419 BS11774_05550 ENOG4105NAE bifunctional deaminase-reductase domain protein BS11774_05560 ENOG4108J8C transporter major facilitator family protein BS11774_05565 ENOG4105C7Z Conserved Protein BS11774_05570 ENOG4107FCW Abortive infection protein BS11774_05580 ENOG4108UW5 maltose o-acetyltransferase BS11774_05585 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BS11774_05595 ENOG4105CGK Exodeoxyribonuclease III BS11774_05600 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BS11774_05605 ENOG4108UUM single-stranded DNA-binding protein BS11774_05610 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BS11774_05615 ENOG4105C3G gtp-binding protein BS11774_05620 ENOG4108J2R molybdopterin oxidoreductase BS11774_05625 ENOG4105VDK protein, conserved in bacteria BS11774_05635 ENOG4108ZDA Sporulation protein YyaC BS11774_05640 ENOG4105FA0 parb-like partition protein BS11774_05645 ENOG4107QJE Chromosome Partitioning Protein BS11774_05660 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BS11774_05665 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BS11774_05670 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BS11774_05685 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BS11774_05695 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BS11774_05700 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BS11774_05705 ENOG410848D S4 domain protein YaaA BS11774_05720 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS11774_05725 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS11774_05760 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BS11774_05770 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BS11774_05775 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BS11774_05785 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BS11774_05795 ENOG4105ZMH deoxynucleoside kinase BS11774_05805 ENOG4105VRS hydrolase family 18 BS11774_05810 ENOG4105GTG Isochorismatase BS11774_05815 ENOG4108Z6B deaminase BS11774_05825 ENOG4105C6E dna polymerase iii BS11774_05830 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BS11774_05835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BS11774_05845 ENOG41067KS pro-sigma K processing BS11774_05885 ENOG4105CDW Resistance protein BS11774_05890 ENOG4105CXN decarboxylase BS11774_05895 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BS11774_05900 ENOG4105X0R protein from nitrogen regulatory protein P-II BS11774_05905 ENOG4105XVJ Protein of unknown function (DUF327) BS11774_05910 ENOG4105FA2 dna polymerase iii BS11774_05915 ENOG4105MA4 psp1 domain protein BS11774_05920 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BS11774_05925 ENOG41060K3 Methyltransferase BS11774_05930 ENOG4105VC4 domain protein BS11774_05935 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BS11774_05940 ENOG4105KRN Transcriptional regulator, abrb family BS11774_05945 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BS11774_05950 ENOG4105F8V Hydrolase, tatD family BS11774_05955 ENOG41069ER domain protein BS11774_05965 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BS11774_05970 ENOG4105XFA sporulation peptidase YabG BS11774_05975 ENOG4105W42 Veg protein BS11774_05980 ENOG4105XEW small acid-soluble spore protein BS11774_05985 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BS11774_05990 ENOG4105DFT pur operon repressor BS11774_05995 ENOG4105KME endoribonuclease L-psp BS11774_06000 ENOG4105K4W Could be involved in septation (By similarity) BS11774_06005 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BS11774_06010 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BS11774_06015 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BS11774_06020 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BS11774_06030 ENOG4108JA2 transcriptioN-repair coupling factor BS11774_06035 ENOG4108M14 stage v sporulation protein t BS11774_06045 ENOG4108IY2 MazG family BS11774_06050 ENOG41082I2 s4 domain protein BS11774_06055 ENOG4105VYY sporulation protein yabp BS11774_06070 ENOG41060GV RNA binding s1 domain protein BS11774_06100 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BS11774_06105 ENOG4108UGV hypoxanthine phosphoribosyltransferase BS11774_06110 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BS11774_06125 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BS11774_06130 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BS11774_06135 ENOG4105C6T cysteine synthase BS11774_06140 ENOG4105CRQ synthase (Component I) BS11774_06145 ENOG4105DDQ anthranilate synthase BS11774_06150 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BS11774_06155 ENOG4105EEI dihydropteroate synthase BS11774_06160 ENOG4105KRF dihydroneopterin aldolase BS11774_06165 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BS11774_06175 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BS11774_06180 ENOG4105CRK lysyL-tRNA synthetase BS11774_06205 ENOG4108Z0C Uvrb UvrC protein BS11774_06210 ENOG41066A3 ATP guanido phosphotransferase BS11774_06220 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BS11774_06225 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BS11774_06230 ENOG4105CTP PilT protein domain protein BS11774_06235 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BS11774_06240 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BS11774_06245 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BS11774_06255 ENOG4105D7W serine acetyltransferase BS11774_06260 ENOG4105C8N cysteinyl-tRNA synthetase BS11774_06265 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BS11774_06270 ENOG4105C2N RNA methyltransferase TrmH family group 3 BS11774_06275 ENOG4105M0M Tetracycline resistance protein BS11774_06295 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BS11774_06300 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BS11774_06310 ENOG4108VZM 50s ribosomal protein L10 BS11774_06315 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BS11774_06320 ENOG4107Y49 methyltransferase BS11774_06325 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS11774_06330 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS11774_06335 ENOG4105XPM ribosomal protein BS11774_06340 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BS11774_06345 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BS11774_06350 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BS11774_06355 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BS11774_06360 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BS11774_06365 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BS11774_06370 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BS11774_06375 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BS11774_06380 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BS11774_06385 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BS11774_06390 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BS11774_06395 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BS11774_06400 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BS11774_06405 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BS11774_06410 ENOG41082SA 50s ribosomal protein l29 BS11774_06415 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BS11774_06420 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BS11774_06430 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BS11774_06440 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BS11774_06445 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BS11774_06450 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BS11774_06455 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BS11774_06460 ENOG4105VPB 50S ribosomal protein L30 BS11774_06465 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BS11774_06470 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BS11774_06480 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BS11774_06490 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BS11774_06500 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BS11774_06505 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BS11774_06510 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS11774_06515 ENOG4108ZT0 50S ribosomal protein l17 BS11774_06520 ENOG4108JJB ABC transporter BS11774_06525 ENOG4108JJB ABC transporter BS11774_06530 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BS11774_06535 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BS11774_06540 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BS11774_06545 ENOG4108UJD 30S ribosomal protein S9 BS11774_06550 ENOG4108I0C methyltransferase BS11774_06565 ENOG4105D1F ATP-binding protein BS11774_06580 ENOG4108NMV polysaccharide deacetylase BS11774_06615 ENOG410635T phage-like element pbsx protein BS11774_06625 ENOG41067QW Transcriptional regulator BS11774_06685 ENOG4105CDU Replicative dna helicase BS11774_06695 ENOG4105QBX endodeoxyribonuclease RusA BS11774_06790 ENOG4106BHF BS11774_06815 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BS11774_06890 ENOG4108SA1 esterase BS11774_06910 ENOG410874W AraC family transcriptional regulator BS11774_06915 ENOG4105EHZ conserved protein UCP016719 BS11774_06920 ENOG4105D17 glycoside hydrolase, family 3 domain protein BS11774_06940 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BS11774_06950 ENOG4105EWC Purine nucleoside phosphorylase BS11774_06980 ENOG4105EMN RNA polymerase sigma factor BS11774_06990 ENOG4105C8B TIGR00159 family BS11774_06995 ENOG4107U5W ybbr family BS11774_07000 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BS11774_07005 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BS11774_07015 ENOG4105D03 DNA-3-methyladenine glycosylase II BS11774_07025 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BS11774_07030 ENOG4108TWJ NADH dehydrogenase subunit 5 BS11774_07050 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BS11774_07055 ENOG4105WAB arsR family transcriptional regulator BS11774_07060 ENOG4108RWP Major Facilitator Superfamily protein BS11774_07075 ENOG4105G0J serine threonine protein kinase BS11774_07085 ENOG4106K80 BS11774_07095 ENOG4106DDH Sporulation-specific SASP protein BS11774_07105 ENOG4108HWY Beta-lactamase BS11774_07110 ENOG4107E6A Cytochrome p-450 BS11774_07120 ENOG4107QTZ amino acid BS11774_07130 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BS11774_07135 ENOG4105CXY transporter BS11774_07150 ENOG410645S MarR family Transcriptional regulator BS11774_07155 ENOG4105DCM major facilitator superfamily BS11774_07170 ENOG410631K Membrane BS11774_07175 ENOG4106AXJ AraC family transcriptional regulator BS11774_07180 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BS11774_07185 ENOG4108TCS Glutamyl endopeptidase BS11774_07195 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BS11774_07200 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BS11774_07205 ENOG4107ZTW SNARE associated Golgi BS11774_07220 ENOG4105C72 UPF0176 protein BS11774_07230 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane BS11774_07235 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BS11774_07240 ENOG4108X79 transcriptional regulator BS11774_07250 ENOG4105CM2 brancheD-chain amino acid aminotransferase BS11774_07255 ENOG4108IQI permease BS11774_07260 ENOG4108J5H Homocysteine s-methyltransferase BS11774_07275 ENOG4105CSV Glutaminase BS11774_07295 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase BS11774_07300 ENOG4105C26 Dehydrogenase BS11774_07305 ENOG4105DJB Major Facilitator Superfamily BS11774_07310 ENOG4105EQX glucarate dehydratase BS11774_07315 ENOG41073TP transcriptional regulator BS11774_07320 ENOG4105CTX dehydratase BS11774_07335 ENOG4106UX7 integral membrane protein BS11774_07340 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS11774_07375 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BS11774_07400 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 BS11774_07405 ENOG4105DVH amino acid BS11774_07420 ENOG4105CDH Citrulline--aspartate ligase BS11774_07430 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BS11774_07450 ENOG4105DGI Alkaline phosphatase BS11774_07455 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS11774_07460 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BS11774_07465 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BS11774_07470 ENOG4107EPV Aminotransferase class V BS11774_07475 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS11774_07480 ENOG4105J7D transcriptional regulator BS11774_07485 ENOG4107RB3 L-asparaginase BS11774_07490 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BS11774_07500 ENOG41060AI SEC-C motif BS11774_07510 ENOG4107Y7X LytTR BS11774_07515 ENOG4108IUW ABC transporter BS11774_07520 ENOG4108SDH ABC, transporter BS11774_07525 ENOG4107SET aldo keto reductase BS11774_07555 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BS11774_07565 ENOG4105DSE periplasmic solute binding protein BS11774_07570 ENOG4105DIK (ABC) transporter BS11774_07580 ENOG4105DEN Luciferase family BS11774_07585 ENOG4108N0M stress protein BS11774_07590 ENOG4106FN3 tellurium resistance protein BS11774_07595 ENOG4106FN3 tellurium resistance protein BS11774_07600 ENOG4107TS3 membrane protein, TerC BS11774_07605 ENOG4108TTB tellurium resistance protein BS11774_07615 ENOG41079KZ Major Facilitator Superfamily BS11774_07625 ENOG4107XZQ multidrug resistance protein BS11774_07630 ENOG4108A65 Transcriptional regulator BS11774_07635 ENOG4108IJ7 Glycine betaine BS11774_07640 ENOG4107SQ8 Glycine betaine BS11774_07670 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BS11774_07705 ENOG4105EIG urea carboxylase-associated protein 1 BS11774_07710 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BS11774_07715 ENOG4105I1F Resistance protein BS11774_07720 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BS11774_07730 ENOG41089UC methyltransferase, type 11 BS11774_07735 ENOG4105C5Q Transcriptional regulator BS11774_07740 ENOG4105I82 acetyl xylan esterase BS11774_07745 ENOG410756H nucleotidyltransferase BS11774_07755 ENOG4105C26 Dehydrogenase BS11774_07760 ENOG4105CK7 Sodium proline symporter BS11774_07765 ENOG4107YHD transcriptional regulator BS11774_07775 ENOG4108PJD permease BS11774_07790 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BS11774_07795 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BS11774_07800 ENOG4108IFG nitrite reductase, (NAD(P)H) BS11774_07805 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BS11774_07825 ENOG4105S7A ErfK ybiS ycfS ynhG family protein BS11774_07835 ENOG4105CKI cobalamin synthesis protein BS11774_07840 ENOG4105E5Q amino acid AbC transporter BS11774_07845 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BS11774_07850 ENOG4105HHM rdd domain containing protein BS11774_07860 ENOG4105CS2 ec 3.2.1.21 BS11774_07875 ENOG4105C8Q Methyl-accepting chemotaxis BS11774_07880 ENOG41080HJ 6-phospho 3-hexuloisomerase BS11774_07885 ENOG4108VA3 3-hexulose-6-phosphate synthase BS11774_07890 ENOG4105KVH Transcriptional regulator BS11774_07895 ENOG4105CEY Amp-dependent synthetase and ligase BS11774_07925 ENOG4105SX7 Transporter BS11774_07935 ENOG4105W8Z 4'-phosphopantetheinyl transferase BS11774_07945 ENOG4105CDA abc transporter atp-binding protein BS11774_07950 ENOG4105DRP amino acid AbC transporter BS11774_07960 ENOG4106P55 Transcriptional regulator BS11774_07965 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BS11774_07970 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BS11774_07975 ENOG41069ZX BS11774_07980 ENOG41069ZX BS11774_07990 ENOG4105DUX Transporter BS11774_08005 ENOG4105E1K spore germination protein BS11774_08025 ENOG4107WD8 ABC transporter, permease BS11774_08030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS11774_08035 ENOG4105BZU Histidine kinase BS11774_08060 ENOG4105CFH Aspartokinase BS11774_08065 ENOG4105DHS permease protein BS11774_08070 ENOG4105CM4 permease protein BS11774_08075 ENOG4108IPW abc transporter atp-binding protein BS11774_08090 ENOG4105R8C Transcriptional regulator BS11774_08095 ENOG4108DBC nitroreductase BS11774_08100 ENOG41067V3 Antibiotic biosynthesis monooxygenase BS11774_08105 ENOG4105YVS arsR family transcriptional regulator BS11774_08115 ENOG4108JPW Aminotransferase BS11774_08120 ENOG4105C26 Dehydrogenase BS11774_08130 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BS11774_08135 ENOG4105KTB nuclear export factor GLE1 BS11774_08140 ENOG4108T5E Copper resistance protein BS11774_08145 ENOG4108ZYE Transcriptional regulator BS11774_08170 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS11774_08175 ENOG4108ZX0 Signal peptidase I BS11774_08200 ENOG4105E7W lamb ycsf family protein BS11774_08205 ENOG4105C5A transporter BS11774_08210 ENOG4105CFM UPF0317 protein BS11774_08215 ENOG4105P4J Allophanate hydrolase, subunit 1 BS11774_08225 ENOG4107258 Transcriptional regulator BS11774_08230 ENOG4105XJB lipolytic protein G-D-S-L family BS11774_08240 ENOG41061CK Antibiotic biosynthesis monooxygenase BS11774_08245 ENOG4107RVG penicillin-binding protein BS11774_08250 ENOG4107QM2 Aldo Keto reductase BS11774_08255 ENOG4105ETD TRANSCRIPTIONal BS11774_08265 ENOG4105HMZ Methyltransferase BS11774_08270 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BS11774_08285 ENOG410606W general stress protein BS11774_08295 ENOG4105VCH membrane BS11774_08305 ENOG4105C9U ATP-dependent DNA helicase RecQ BS11774_08320 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BS11774_08325 ENOG4107R8N Glycosyl transferase, family 2 BS11774_08335 ENOG4105C0X amino acid BS11774_08355 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BS11774_08365 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BS11774_08370 ENOG4105EU9 BS11774_08375 ENOG4105QVS general stress protein BS11774_08380 ENOG41082W1 Cupin 2, conserved barrel domain protein BS11774_08400 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BS11774_08405 ENOG4108MRH transcriptional regulatory protein BS11774_08410 ENOG4107QJT sodium dicarboxylate symporter BS11774_08415 ENOG4106F5Q Membrane BS11774_08420 ENOG4105CJ1 ABC, transporter BS11774_08435 ENOG4105FDT acyl-CoA dehydrogenase BS11774_08455 ENOG4105SZ6 Thioredoxin BS11774_08460 ENOG4105CPF Cell wall formation (By similarity) BS11774_08465 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BS11774_08475 ENOG4105C1J atp-dependent rna helicase BS11774_08480 ENOG410905X membrane-flanked domain protein BS11774_08485 ENOG4105CKV Membrane BS11774_08495 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BS11774_08500 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BS11774_08505 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BS11774_08515 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BS11774_08520 ENOG4107MMM Anti-sigma-factor antagonist BS11774_08525 ENOG4105FUA antagonist BS11774_08530 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BS11774_08535 ENOG4107SGM protein serine threonine phosphatase BS11774_08540 ENOG4105WN5 stage II sporulation protein BS11774_08545 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BS11774_08555 ENOG41064BQ Phosphatase BS11774_08635 ENOG4106DF4 Sigma-70, region 4 BS11774_08665 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BS11774_08670 ENOG41068WC Domain of unknown function (DUF955) BS11774_08675 ENOG4108IMY Transcriptional regulator BS11774_08695 ENOG4108RYM conjugative transposon protein BS11774_08710 ENOG4108VJ1 Transcriptional regulator (CarD family BS11774_08725 ENOG4108MCI Transcriptional regulator, ARAC family BS11774_08730 ENOG4108UZ3 Transporter BS11774_08735 ENOG41086D8 Transcriptional regulator BS11774_08740 ENOG4107U9B transcriptional regulator BS11774_08755 ENOG4105CZ9 Domain of unknown function (DU1801) BS11774_08760 ENOG4105GIG BS11774_08770 ENOG4105KRI phosphocarrier protein (HPr BS11774_08775 ENOG4105ST3 Transcriptional regulator BS11774_08780 ENOG4105T38 integral membrane protein BS11774_08785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS11774_08790 ENOG4108ZMQ domain protein BS11774_08800 ENOG4107Z6X Transcriptional regulator BS11774_08810 ENOG41082YX Transcriptional regulator, arsr family BS11774_08815 ENOG4107R5R arsenical pump membrane protein BS11774_08820 ENOG4108UXE Protein tyrosine phosphatase BS11774_08825 ENOG4105Z7P Acetyltransferase (GNAT) family BS11774_08830 ENOG4107Y9U Membrane BS11774_08840 ENOG4108SQ9 flavin reductase domain protein, FMN-binding BS11774_08845 ENOG4108ZHR arsR family transcriptional regulator BS11774_08850 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BS11774_08880 ENOG41076HS cation diffusion facilitator family transporter BS11774_08890 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BS11774_08895 ENOG4108VGI doxx family BS11774_08900 ENOG4105XXY Thioredoxin BS11774_08920 ENOG4108QY0 Membrane BS11774_08940 ENOG4105PF9 Transcriptional regulator BS11774_08950 ENOG4105WQG acetyltransferase BS11774_08960 ENOG4105C85 amino acid BS11774_08970 ENOG41062A4 Transcriptional regulator BS11774_08975 ENOG4105EYF MMPL domain protein BS11774_08980 ENOG4108TVJ Nitroreductase BS11774_08985 ENOG4105FS7 Transcriptional regulator BS11774_08990 ENOG4105C2C drug resistance transporter, Bcr CflA BS11774_09005 ENOG4105DRR Transcriptional regulator, GntR family BS11774_09010 ENOG4105VRS hydrolase family 18 BS11774_09025 ENOG4105G6Z alkaline phosphatase BS11774_09030 ENOG4108ZMX Domain of unknown function (DU1801) BS11774_09040 ENOG4108YM7 Gcn5-related n-acetyltransferase BS11774_09045 ENOG4107TVP HD domain protein BS11774_09050 ENOG41090UD (LipO)protein BS11774_09055 ENOG4105F27 Major Facilitator BS11774_09060 ENOG4105VZJ PTS System BS11774_09065 ENOG4105VCP PTS System BS11774_09070 ENOG4105CK1 PTS System BS11774_09075 ENOG4105CS2 ec 3.2.1.21 BS11774_09080 ENOG4108TZY GntR Family Transcriptional Regulator BS11774_09085 ENOG4105EVU fructokinase BS11774_09090 ENOG4105DG6 mannose-6-phosphate isomerase BS11774_09095 ENOG4105D3P Mannan endo-1,4-beta-mannosidase BS11774_09140 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BS11774_09145 ENOG4105K8N protein family UPF0079, ATPase BS11774_09150 ENOG41072GX Peptidase M22 Glycoprotease BS11774_09155 ENOG410801F ribosomal-protein-alanine acetyltransferase BS11774_09160 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BS11774_09165 ENOG4105C5H ABC transporter BS11774_09170 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BS11774_09175 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BS11774_09180 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS11774_09185 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BS11774_09200 ENOG4108TYN CAAX amino terminal protease family protein BS11774_09205 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BS11774_09210 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BS11774_09225 ENOG4105PGZ NB-ARC domain BS11774_09230 ENOG4105CPQ Dehydrogenase BS11774_09235 ENOG4105CT4 transporter BS11774_09245 ENOG41087YS Phage shock protein A BS11774_09250 ENOG4105DQX Zinc finger domain BS11774_09255 ENOG4108WV1 Pfam:DUF477 BS11774_09265 ENOG4108ZMR Ion transport 2 domain-containing protein BS11774_09275 ENOG4107QNK )-transporter BS11774_09310 ENOG4107YUH hydrolase BS11774_09320 ENOG4107STQ Multicopper oxidase BS11774_09325 ENOG4105C85 amino acid BS11774_09340 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BS11774_09370 ENOG4105C7N Xanthine uracil vitamin C permease BS11774_09395 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BS11774_09400 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BS11774_09405 ENOG4105C83 adenylosuccinate lyase BS11774_09410 ENOG4105C8V SAICAR synthetase BS11774_09415 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BS11774_09420 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BS11774_09425 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BS11774_09435 ENOG4105CXB phosphoribosylaminoimidazole synthetase BS11774_09440 ENOG4108V3E phosphoribosylglycinamide formyltransferase BS11774_09445 ENOG4105DC1 bifunctional purine biosynthesis protein purh BS11774_09450 ENOG4105C12 Phosphoribosylglycinamide synthetase BS11774_09475 ENOG4108R5T secreted protein BS11774_09480 ENOG4105KGF protein, YerC YecD BS11774_09485 ENOG4105CBC glutamate synthase BS11774_09490 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BS11774_09495 ENOG4105C4R Atp-dependent dna helicase BS11774_09500 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BS11774_09510 ENOG4105CRN Aminoglycoside phosphotransferase BS11774_09515 ENOG4105KT7 mgtC SapB transporter BS11774_09520 ENOG4105CK7 Sodium proline symporter BS11774_09525 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BS11774_09530 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BS11774_09535 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BS11774_09540 ENOG4108IG5 Transcriptional regulator BS11774_09550 ENOG4105CBD Diacylglycerol kinase BS11774_09620 ENOG4105CDY transcriptional regulatory protein BS11774_09630 ENOG4105M4P Tetr family transcriptional regulator BS11774_09635 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein BS11774_09640 ENOG4107S9F NmrA family BS11774_09655 ENOG4105WEF catalase BS11774_09660 ENOG4105M18 -acetyltransferase BS11774_09675 ENOG4105C2F Histidine kinase BS11774_09680 ENOG4105EQD regulatoR BS11774_09685 ENOG410769Z extracellular solute-binding protein family 1 BS11774_09690 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BS11774_09695 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BS11774_09700 ENOG4105F5H Glycosyl Hydrolase Family 88 BS11774_09705 ENOG41075H3 AraC family transcriptional regulator BS11774_09710 ENOG4107TDE lipolytic protein G-D-S-L family BS11774_09725 ENOG4105CX8 fg-gap repeat protein BS11774_09730 ENOG4105CX8 fg-gap repeat protein BS11774_09735 ENOG4107TDE lipolytic protein G-D-S-L family BS11774_09745 ENOG4105EKC BS11774_09750 ENOG4105E0S extracellular solute-binding protein family 1 BS11774_09760 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BS11774_09770 ENOG4105H67 Protein of unknown function (DUF421) BS11774_09775 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BS11774_09780 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BS11774_09800 ENOG4106I4J membrane BS11774_09815 ENOG41061H0 Monooxygenase BS11774_09820 ENOG4108R1P BS11774_09825 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BS11774_09840 ENOG4105E0M Sulfatase BS11774_09845 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BS11774_09855 ENOG41090R9 glycosyltransferase BS11774_09860 ENOG4107R51 Glycosyl transferase, family 2 BS11774_09865 ENOG41090R9 glycosyltransferase BS11774_09870 ENOG4105EU0 Major facilitator Superfamily BS11774_09880 ENOG4105CUB amino acid BS11774_09885 ENOG4105C26 Dehydrogenase BS11774_09890 ENOG4105FKZ Methyl-accepting chemotaxis BS11774_09895 ENOG4105C5H ABC transporter BS11774_09905 ENOG4107SWG transcriptional regulator MERR family BS11774_09920 ENOG4105C5H ABC transporter BS11774_09925 ENOG4105FDU atp-dependent rna helicase BS11774_09935 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BS11774_09950 ENOG4105E6M Sulphatase-modifying factor protein BS11774_09955 ENOG4105E0A ABC, transporter BS11774_09960 ENOG4108U1V ABC transporter, permease BS11774_09965 ENOG4105DQ5 transport system permease protein BS11774_09970 ENOG4108HUF Transporter BS11774_09990 ENOG4108J20 pectate lyase BS11774_09995 ENOG4107QPK )-transporter BS11774_10005 ENOG4108MRH transcriptional regulatory protein BS11774_10030 ENOG410855V Acylphosphatase BS11774_10035 ENOG4108RPX mosc domain containing protein BS11774_10055 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BS11774_10090 ENOG4105C5Y PTS System BS11774_10095 ENOG4105CG3 alpha amylase, catalytic region BS11774_10100 ENOG4107414 GntR family transcriptional regulator BS11774_10105 ENOG4108RCM Nitroreductase BS11774_10110 ENOG4105CGH 5'-nucleotidase BS11774_10115 ENOG4107RKG DJ-1/PfpI family BS11774_10130 ENOG4105KJF protein tyrosine phosphatase BS11774_10140 ENOG4107U9T Pfam:Ribonuclease_BN BS11774_10145 ENOG4108ISG Major Facilitator BS11774_10150 ENOG4105UPD Calcium Proton BS11774_10160 ENOG4105D8X mechanosensitive ion channel BS11774_10180 ENOG4106KE4 Dehydrogenase BS11774_10185 ENOG4105D7N magnesium and cobalt transport protein CorA BS11774_10195 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BS11774_10215 ENOG4105BZ1 (ABC) transporter BS11774_10220 ENOG4105CJA serine threonine protein kinase BS11774_10250 ENOG4107RUY (E1 component), alpha subunit BS11774_10260 ENOG4107QKR Dehydrogenase BS11774_10270 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BS11774_10275 ENOG41069DP small acid-soluble spore protein BS11774_10305 ENOG4105F8D glycoside hydrolase family 4 BS11774_10310 ENOG4108Q3X Transcriptional regulator BS11774_10315 ENOG4105CI1 PTS System BS11774_10320 ENOG4105BZ1 (ABC) transporter BS11774_10325 ENOG4105BZ1 (ABC) transporter BS11774_10335 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BS11774_10340 ENOG4105BZU Histidine kinase BS11774_10345 ENOG4105WH1 Two component transcriptional regulator luxr family BS11774_10350 ENOG4105CJ1 ABC, transporter BS11774_10355 ENOG41090VJ ABC-2 type transporter BS11774_10360 ENOG4108KYE ABC-2 type transporter BS11774_10365 ENOG4105U3E Transcriptional regulator BS11774_10370 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BS11774_10375 ENOG4105H93 Acyltransferase family BS11774_10380 ENOG4108YYS metal-dependent hydrolase (By similarity) BS11774_10385 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS11774_10390 ENOG410834F Transcriptional regulator BS11774_10400 ENOG4108MES Periplasmic binding protein BS11774_10405 ENOG4105DQ5 transport system permease protein BS11774_10410 ENOG4108IHU transport system permease protein BS11774_10415 ENOG4105JAB phenazine biosynthesis protein, phzf family BS11774_10420 ENOG4107Y03 Nitroreductase BS11774_10435 ENOG4105ECP epimerase BS11774_10450 ENOG4105F27 Major Facilitator BS11774_10475 ENOG4106AKJ BS11774_10480 ENOG4105D74 hydrolase BS11774_10485 ENOG4105CKK Glycosyl transferase, family 2 BS11774_10490 ENOG4105EJV Membrane BS11774_10495 ENOG41067AE Membrane-bound metal-dependent hydrolase BS11774_10500 ENOG4105CEN a g-specific adenine glycosylase BS11774_10505 ENOG4106BXE BS11774_10510 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BS11774_10525 ENOG4105EVI UPF0374 protein BS11774_10530 ENOG4105BZ1 (ABC) transporter BS11774_10535 ENOG4107NBY Membrane BS11774_10545 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS11774_10550 ENOG4105G5W regulator Fur family BS11774_10680 ENOG4105EC3 peptidase S51, dipeptidase E BS11774_10685 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BS11774_10690 ENOG4105DNP FAD linked oxidase domain protein BS11774_10705 ENOG4105E2Y ABC, transporter BS11774_10710 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BS11774_10715 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BS11774_10720 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BS11774_10730 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BS11774_10735 ENOG4107D63 BS11774_10740 ENOG4105VZ8 Transcriptional regulator BS11774_10755 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BS11774_10765 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BS11774_10785 ENOG4105CYN Serine protein kinase BS11774_10790 ENOG4106AKX UPF0229 protein BS11774_10795 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BS11774_10800 ENOG4105CW7 secretion protein, HlyD family BS11774_10805 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS11774_10810 ENOG4105CS1 NAD(P)H quinone oxidoreductase BS11774_10830 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BS11774_10835 ENOG4105CZV ABC transporter BS11774_10840 ENOG4105CJ1 ABC, transporter BS11774_10845 ENOG4108TU7 Inherit from COG: (ABC) transporter BS11774_10850 ENOG4105VEQ Cold shock protein BS11774_10905 ENOG4108YBP pseudouridine synthase BS11774_10915 ENOG41080XP Cbs domain BS11774_10925 ENOG4107YBY Hydrolase BS11774_10930 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BS11774_10935 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS11774_10940 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BS11774_10950 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BS11774_10955 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BS11774_10965 ENOG4105BZU Histidine kinase BS11774_10970 ENOG4105WH1 Two component transcriptional regulator luxr family BS11774_11005 ENOG4105ED1 spovr family BS11774_11010 ENOG4105G6Z alkaline phosphatase BS11774_11025 ENOG4105BZN citrate synthase BS11774_11030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BS11774_11035 ENOG4105CUB amino acid BS11774_11040 ENOG4105C8J )-transporter BS11774_11045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS11774_11060 ENOG4105J37 BS11774_11065 ENOG4108AEY RNA polymerase sigma factor BS11774_11070 ENOG4108FN7 Aldo keto reductase BS11774_11075 ENOG4105F6E Acyl-transferase BS11774_11085 ENOG4105C37 (CBS) domain BS11774_11095 ENOG4105CHM Aminotransferase BS11774_11100 ENOG4105C37 (CBS) domain BS11774_11110 ENOG4105WMR Protein CrcB homolog BS11774_11115 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BS11774_11125 ENOG4105D64 Mechanosensitive ion channel BS11774_11130 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BS11774_11135 ENOG4107VMI polysaccharide deacetylase BS11774_11140 ENOG4105F0I Aminotransferase BS11774_11160 ENOG4105BZ1 (ABC) transporter BS11774_11165 ENOG4105BZ1 (ABC) transporter BS11774_11190 ENOG410839P BS11774_11200 ENOG4106MP8 UPF0754 membrane protein BS11774_11205 ENOG4105WZB UPF0342 protein BS11774_11210 ENOG4105F1N DNA alkylation repair BS11774_11220 ENOG4105D4P Coproporphyrinogen iii oxidase BS11774_11225 ENOG4107S91 Sodium hydrogen exchanger BS11774_11230 ENOG4105NCW Trka-c domain protein BS11774_11240 ENOG4105CGU Enoyl-CoA hydratase BS11774_11250 ENOG4108IUX (ABC) transporter BS11774_11255 ENOG4105RHA ABC transporter, permease BS11774_11260 ENOG4107VRP DNA repair exonuclease BS11774_11265 ENOG4106D4I domain protein BS11774_11280 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BS11774_11325 ENOG4105NBU tryptophan transport protein BS11774_11330 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BS11774_11335 ENOG4105K59 histidine triad (HIT) protein BS11774_11370 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BS11774_11375 ENOG4105BZ4 penicillin-binding protein BS11774_11380 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BS11774_11385 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BS11774_11390 ENOG4105C1Q protoporphyrinogen oxidase BS11774_11400 ENOG4105ECB domain protein BS11774_11410 ENOG41090T1 Membrane BS11774_11420 ENOG4105DER m42 family BS11774_11435 ENOG4106AXD BS11774_11440 ENOG4108RQ5 Beta-lactamase domain-containing protein BS11774_11445 ENOG4105DF9 Lipoate-protein, ligase BS11774_11455 ENOG4105CEY Amp-dependent synthetase and ligase BS11774_11465 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BS11774_11470 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS11774_11475 ENOG4105KD7 acetyltransferase BS11774_11485 ENOG4108HUF Transporter BS11774_11490 ENOG4107TB6 phosphoglycerate mutase BS11774_11500 ENOG4107F3J Amp-dependent synthetase and ligase BS11774_11505 ENOG4107ZYJ bioY protein BS11774_11510 ENOG4106YBV Methyl-accepting chemotaxis BS11774_11530 ENOG4105XVF Competence transcription factor BS11774_11535 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BS11774_11540 ENOG4105X3H Excalibur domain protein BS11774_11545 ENOG4105E1V na solute symporter BS11774_11550 ENOG4106CAD Protein of unknown function (DUF3311) BS11774_11555 ENOG41060YP BS11774_11570 ENOG4107SCK Monooxygenase BS11774_11575 ENOG4108INS Transcriptional regulator BS11774_11590 ENOG4105TRI Hydrolase BS11774_11605 ENOG4108KK1 membrane protein AbrB duplication BS11774_11610 ENOG4106K7D Major facilitator family transporter BS11774_11615 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BS11774_11620 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding BS11774_11635 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BS11774_11645 ENOG4105EYH Exonuclease BS11774_11695 ENOG4105ERH Fumarylacetoacetate hydrolase BS11774_11705 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS11774_11715 ENOG4105CAQ asparagine synthetase BS11774_11730 ENOG4105UQX Mate efflux family protein BS11774_11735 ENOG4106HBX Transcriptional Regulator AraC Family BS11774_11740 ENOG4105ETE Transcriptional regulator (LacI family BS11774_11745 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BS11774_11750 ENOG4105SF0 DinB family BS11774_11755 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BS11774_11760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS11774_11765 ENOG4105MYW Pentapeptide repeat protein BS11774_11770 ENOG4107S9D Alpha beta hydrolase BS11774_11780 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BS11774_11785 ENOG4107RIQ Sulfate adenylate transferase BS11774_11790 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BS11774_11795 ENOG4108N5B 2-phosphosulfolactate phosphatase BS11774_11800 ENOG41061P3 phosphosulfolactate synthase BS11774_11810 ENOG4105DIA mandelate racemase muconate lactonizing BS11774_11825 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS11774_11845 ENOG4105WEF catalase BS11774_11860 ENOG41090VF Stage v sporulation protein ac BS11774_11865 ENOG4105CZ3 stage V sporulation protein ad BS11774_11880 ENOG4108QY0 Membrane BS11774_11890 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS11774_11895 ENOG4105H67 Protein of unknown function (DUF421) BS11774_11900 ENOG4107RCC Major Facilitator Superfamily BS11774_11905 ENOG4108SZE gCN5-related N-acetyltransferase BS11774_11910 ENOG4105MA6 gCN5-related N-acetyltransferase BS11774_11920 ENOG4108VPT UPF0234 protein BS11774_11925 ENOG4105QNR S1 RNA binding domain protein BS11774_11945 ENOG4105K7K Transcriptional regulator BS11774_11955 ENOG410751J BS11774_11960 ENOG4105D4Y metalloprotease BS11774_11965 ENOG4105EPR degv family BS11774_11970 ENOG4107AYK membrAne BS11774_11980 ENOG41073B9 BS11774_11985 ENOG4108KP7 hydrolase BS11774_11990 ENOG4108MXZ Esterase BS11774_11995 ENOG4105VG1 fes assembly suf system protein BS11774_12005 ENOG4105IQ5 FAD linked oxidase domain protein BS11774_12015 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BS11774_12030 ENOG4105C8Y Acetylornithine aminotransferase BS11774_12035 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BS11774_12045 ENOG4105DBV ornithine carbamoyltransferase BS11774_12070 ENOG4107RMD Basic membrane lipoprotein BS11774_12085 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BS11774_12090 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BS11774_12100 ENOG4105C3U ABC transporter BS11774_12105 ENOG4108JQ7 (ABC) transporter BS11774_12120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS11774_12130 ENOG4105C31 Tryptophanyl-tRNA synthetase BS11774_12140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS11774_12145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS11774_12155 ENOG4108JQ7 (ABC) transporter BS11774_12170 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BS11774_12175 ENOG4108ZCF integral membrane protein BS11774_12180 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BS11774_12190 ENOG4105DPN Oligoendopeptidase f BS11774_12205 ENOG4105T58 Dithiol-disulfide isomerase BS11774_12210 ENOG4108Z18 K06886 hemoglobin BS11774_12215 ENOG4105E4C Lytic transglycosylase catalytic BS11774_12220 ENOG4105MIX Adenylate cyclase BS11774_12235 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BS11774_12240 ENOG4105EMS pseudouridine synthase BS11774_12255 ENOG4105ETU transcriptional activator (TenA BS11774_12260 ENOG4108VEU Thiamine monophosphate synthase BS11774_12275 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BS11774_12280 ENOG4105D06 uba thif-type nad fad binding protein BS11774_12285 ENOG4105DWF phosphomethylpyrimidine kinase BS11774_12290 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BS11774_12295 ENOG4107A88 BS11774_12345 ENOG4105ENA helicase BS11774_12365 ENOG4108ZMI UPF0477 protein BS11774_12375 ENOG4105C28 cystathionine BS11774_12380 ENOG4105C28 cystathionine BS11774_12385 ENOG4105D9U N-acetyltransferase BS11774_12390 ENOG4105JHY Membrane BS11774_12430 ENOG4108PSK reductase BS11774_12445 ENOG4105DM4 PTS System BS11774_12450 ENOG4105DG6 mannose-6-phosphate isomerase BS11774_12455 ENOG4105G7B Protein of unknown function (DUF2992) BS11774_12470 ENOG4105VMI -acetyltransferase BS11774_12480 ENOG4108Z66 YbaK ebsC protein BS11774_12500 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BS11774_12510 ENOG4108ZJ4 polysaccharide deacetylase BS11774_12515 ENOG4107CUJ Protein of unknown function (DUF2690) BS11774_12540 ENOG4108IEG Formate dehydrogenase Alpha subunit BS11774_12565 ENOG4106A3M Cytochrome p-450 BS11774_12570 ENOG41087PP glycosyltransferase MGT family BS11774_12580 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BS11774_12585 ENOG4105C4B ABC transporter, permease BS11774_12590 ENOG4108IXI (ABC) transporter BS11774_12600 ENOG4105Q95 Cupin 2, conserved barrel domain protein BS11774_12615 ENOG4105D2H Uronic isomerase BS11774_12620 ENOG4105CT4 transporter BS11774_12625 ENOG4105DG4 malate L-lactate dehydrogenase BS11774_12635 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BS11774_12640 ENOG4105DMW Dehydrogenase reductase BS11774_12645 ENOG4108I5G Major Facilitator superfamily BS11774_12650 ENOG4107KJX Transcriptional regulator BS11774_12655 ENOG4107QZW Altronate oxidoreductase BS11774_12660 ENOG4105CTX dehydratase BS11774_12665 ENOG4107TSN permease BS11774_12700 ENOG41068K0 YCII-related domain BS11774_12705 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BS11774_12710 ENOG4105KWG Pfam:DUF1696 BS11774_12715 ENOG4105K7W phage-related replication protein BS11774_12720 ENOG4105WEF catalase BS11774_12725 ENOG410635T phage-like element pbsx protein BS11774_12770 ENOG4108TFU terminase (Small subunit) BS11774_12775 ENOG4105IG6 Phage terminase, large subunit BS11774_12780 ENOG4108MDF Phage Portal Protein BS11774_12805 ENOG41060SN BS11774_12820 ENOG4105PQS phage protein BS11774_12825 ENOG4105FR7 XkdM protein, phage-like element PBSX BS11774_12830 ENOG4105MTC XkdN-like protein BS11774_12840 ENOG4108FKH Transglycosylase SLT domain BS11774_12845 ENOG4108WZM domain protein BS11774_12850 ENOG4105X7F BS11774_12860 ENOG4105MFU Protein of unknown function (DUF2634) BS11774_12865 ENOG41066EA baseplate J family protein BS11774_12870 ENOG410906S phage-like element pbsx protein xkdt BS11774_12880 ENOG41068G1 BS11774_12910 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BS11774_12925 ENOG4105CJ3 phosphate transporter BS11774_12930 ENOG4107GRR phosphate transport regulator BS11774_12935 ENOG4107R7I amino acid BS11774_12945 ENOG4105EDW glycosyl transferase, family 39 BS11774_12950 ENOG4105CKK Glycosyl transferase, family 2 BS11774_12955 ENOG4105C0H protease BS11774_12965 ENOG4108ME1 Peptidase M55 D-aminopeptidase BS11774_12970 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS11774_12975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS11774_12980 ENOG4105C3U ABC transporter BS11774_12990 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BS11774_12995 ENOG4105DTQ mandelate racemase muconate lactonizing BS11774_13000 ENOG4107SN7 NLP P60 protein BS11774_13005 ENOG4108JQ7 (ABC) transporter BS11774_13010 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BS11774_13015 ENOG4107TUM Amidinotransferase BS11774_13020 ENOG4108S4H thioesterase Superfamily protein BS11774_13025 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BS11774_13045 ENOG4108428 Inherit from COG: -acetyltransferase BS11774_13055 ENOG41080TC multidrug resistance protein BS11774_13060 ENOG4105CIY formyltetrahydrofolate deformylase BS11774_13065 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BS11774_13080 ENOG4105K56 Transcriptional regulator BS11774_13085 ENOG4108ZHJ Organic hydroperoxide resistance protein BS11774_13095 ENOG4107Y2X deaminase BS11774_13105 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BS11774_13110 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS11774_13120 ENOG4108W7F transporter, permease BS11774_13125 ENOG4108JJB ABC transporter BS11774_13130 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BS11774_13135 ENOG4108X43 YKOF domain protein BS11774_13140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS11774_13145 ENOG41062D9 Histidine kinase BS11774_13155 ENOG4106849 propeptide, pepSY amd peptidase M4 BS11774_13170 ENOG4105CJW magnesium transporter BS11774_13180 ENOG4105V75 Transcriptional regulator BS11774_13225 ENOG4105DQE DNA ligase BS11774_13230 ENOG4105FDF Could be involved in DNA repair (By similarity) BS11774_13240 ENOG4107T5V SNARE associated Golgi BS11774_13245 ENOG4107TS3 membrane protein, TerC BS11774_13250 ENOG4108WZW RNA polymerase sigma BS11774_13260 ENOG410681C small acid-soluble spore protein BS11774_13270 ENOG4105D0M Protease HtpX homolog BS11774_13290 ENOG4108TGC Acyltransferase BS11774_13295 ENOG4105BZU Histidine kinase BS11774_13300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BS11774_13305 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BS11774_13310 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BS11774_13315 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BS11774_13325 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit BS11774_13330 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BS11774_13335 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BS11774_13340 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BS11774_13365 ENOG4105BZU Histidine kinase BS11774_13375 ENOG41090MY MarR family Transcriptional regulator BS11774_13380 ENOG4105ER2 Ompa motb domain protein BS11774_13385 ENOG4105E14 MotA TolQ exbB proton channel BS11774_13400 ENOG4108K88 Membrane BS11774_13405 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BS11774_13410 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BS11774_13415 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BS11774_13420 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BS11774_13440 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BS11774_13445 ENOG4105FEA Spore maturation protein BS11774_13480 ENOG4105F0V Cell wall hydrolase BS11774_13495 ENOG4105C59 p-type ATPase BS11774_13505 ENOG4105DC7 peptidase M24 BS11774_13515 ENOG4105CID antiterminator BS11774_13525 ENOG4105KRI phosphocarrier protein (HPr BS11774_13530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BS11774_13540 ENOG4105F6S Spore photoproduct lyase BS11774_13550 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BS11774_13555 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BS11774_13560 ENOG4105K4I Scp-like extracellular BS11774_13590 ENOG4105CHM Aminotransferase BS11774_13600 ENOG4107R88 Chemotaxis protein (CheV) BS11774_13605 ENOG4105UIN BS11774_13615 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BS11774_13625 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BS11774_13630 ENOG4105EPM Diguanylate phosphodiesterase BS11774_13635 ENOG4107IN1 Protein of unknown function (DUF1797) BS11774_13640 ENOG4108XRC Protein of unknown function (DUF458) BS11774_13670 ENOG4105NQC Flavodoxin BS11774_13680 ENOG4105CH2 amidohydrolase BS11774_13690 ENOG4105D8X mechanosensitive ion channel BS11774_13695 ENOG4105D3R alkyl hydroperoxide reductase BS11774_13700 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS11774_13715 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BS11774_13720 ENOG4105D06 uba thif-type nad fad binding protein BS11774_13725 ENOG4105CVM Molybdenum cofactor synthesis domain protein BS11774_13730 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BS11774_13735 ENOG4108ZAF Molybdopterin BS11774_13740 ENOG41067WU Molybdopterin converting factor (Subunit 1) BS11774_13745 ENOG4105BZ1 (ABC) transporter BS11774_13750 ENOG4105BZ1 (ABC) transporter BS11774_13760 ENOG4107X8C Efflux transporter RND family MFP subunit BS11774_13765 ENOG4105C19 ABC transporter BS11774_13770 ENOG4107RBB ABC transporter, permease BS11774_13775 ENOG4105E98 transcriptional regulator DeoR family BS11774_13780 ENOG4105DE4 1-phosphofructokinase BS11774_13785 ENOG4105DM4 PTS System BS11774_13790 ENOG4105C3F Signal peptidase i BS11774_13800 ENOG4105C5H ABC transporter BS11774_13805 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BS11774_13830 ENOG4105BZU Histidine kinase BS11774_13840 ENOG4107ZYR domain protein BS11774_13850 ENOG4105CN5 Metallo-Beta-Lactamase BS11774_13860 ENOG4108X4Q Hydrolase BS11774_13865 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BS11774_13885 ENOG4105CPP Dehydrogenase, E1 component BS11774_13890 ENOG4105C7S Dehydrogenase BS11774_13895 ENOG4107QN2 dihydrolipoyl dehydrogenase BS11774_13910 ENOG4105CXN decarboxylase BS11774_13915 ENOG4105WBI UPF0223 protein BS11774_13930 ENOG4105ECY inositol monophosphatase BS11774_13940 ENOG4105JQZ Methyltransferase BS11774_13985 ENOG4105CI3 gtp-binding protein typa BS11774_13990 ENOG4105QA2 BS11774_14005 ENOG4108IAB Phoh family BS11774_14015 ENOG4105CSV Glutaminase BS11774_14020 ENOG4105ZPI UPF0358 protein BS11774_14025 ENOG4105CNI cell division protein FtsW BS11774_14030 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BS11774_14040 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BS11774_14050 ENOG4105BZ9 Cytochrome C oxidase, subunit I BS11774_14055 ENOG4105CCU oxidase (Subunit III) BS11774_14060 ENOG41064X9 cytochrome C oxidase subunit IV BS11774_14075 ENOG41080XQ Signal transduction protein with cbs domains BS11774_14080 ENOG4106UY4 Inherit from COG: Scp-like extracellular BS11774_14100 ENOG4105WUC UPF0298 protein BS11774_14105 ENOG4106H78 methyltransferase BS11774_14110 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BS11774_14115 ENOG4105H20 Sporulation integral membrane protein YlbJ BS11774_14120 ENOG4105D78 K07001 NTE family protein BS11774_14125 ENOG41063PX domain protein BS11774_14130 ENOG4105CDE UPF0348 protein BS11774_14140 ENOG4105KNH Nucleic acid-binding protein BS11774_14145 ENOG41067VY 50S ribosomal protein L32 BS11774_14170 ENOG4108V6E Cell division protein mraZ BS11774_14175 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BS11774_14185 ENOG4105CJN penicillin-binding protein BS11774_14190 ENOG4105CJN penicillin-binding protein BS11774_14195 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BS11774_14200 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BS11774_14205 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BS11774_14210 ENOG4105CNI cell division protein FtsW BS11774_14215 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BS11774_14220 ENOG4105D4A Cell wall formation (By similarity) BS11774_14225 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BS11774_14230 ENOG4108R2U division initiation protein BS11774_14240 ENOG4105K67 small basic protein BS11774_14245 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BS11774_14250 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BS11774_14260 ENOG4105FFI sigma-e processing peptidase spoiiga BS11774_14265 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS11774_14275 ENOG4105DKW ABC transporter BS11774_14285 ENOG4105WR5 sporulation protein, YlmC YmxH family BS11774_14290 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BS11774_14295 ENOG4105DFA alanine racemase domain protein BS11774_14300 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BS11774_14305 ENOG41067XK integral membrane protein BS11774_14310 ENOG4105DBK s4 domain protein BS11774_14320 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BS11774_14330 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BS11774_14335 ENOG4105C34 Pseudouridine synthase BS11774_14340 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BS11774_14350 ENOG4105CXT aspartate transcarbamylase BS11774_14360 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BS11774_14365 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BS11774_14370 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BS11774_14375 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BS11774_14380 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BS11774_14385 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BS11774_14390 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BS11774_14400 ENOG4107S4M Sulfate adenylate transferase BS11774_14405 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BS11774_14410 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BS11774_14415 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BS11774_14420 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BS11774_14425 ENOG4105F23 Fibronectin-binding protein BS11774_14435 ENOG4105DSJ YicC domain protein BS11774_14440 ENOG4105KC4 UPF0296 protein BS11774_14445 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BS11774_14455 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BS11774_14460 ENOG4105C25 Primosomal protein n' BS11774_14465 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BS11774_14470 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BS11774_14475 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BS11774_14480 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BS11774_14485 ENOG4108ZF3 Phosphatase BS11774_14490 ENOG4105D9P serine threonine protein kinase BS11774_14495 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BS11774_14500 ENOG4105DJV ribulose-phosphate 3-epimerase BS11774_14505 ENOG4105FJ0 thiamine BS11774_14515 ENOG4105VB9 50S ribosomal protein l28 BS11774_14520 ENOG4108ZAA Alkaline-shock protein BS11774_14525 ENOG4105DP4 dak2 domain fusion protein ylov BS11774_14535 ENOG4105EJQ L-serine dehydratase BS11774_14540 ENOG4105CB5 ATP-dependent DNA helicase recG BS11774_14545 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BS11774_14555 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BS11774_14560 ENOG4105CHR reductase BS11774_14565 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BS11774_14570 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BS11774_14575 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BS11774_14580 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BS11774_14590 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BS11774_14600 ENOG4105K5M 30s ribosomal protein S16 BS11774_14605 ENOG4108BW8 UPF0109 protein BS11774_14615 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BS11774_14620 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BS11774_14625 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BS11774_14630 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BS11774_14635 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BS11774_14645 ENOG4105VM1 flagellar BS11774_14650 ENOG4105CMV Succinyl-CoA synthetase subunit beta BS11774_14655 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BS11774_14660 ENOG4105C79 DNA protecting protein DprA BS11774_14665 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BS11774_14670 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BS11774_14675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS11774_14680 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BS11774_14685 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BS11774_14695 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BS11774_14700 ENOG4108ZC9 flagellar basal-body rod protein flgc BS11774_14705 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BS11774_14710 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BS11774_14715 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BS11774_14730 ENOG4106YF4 Flagellar biosynthesis chaperone BS11774_14740 ENOG410696Y Flagellar hook-length control protein BS11774_14745 ENOG410822I Flagellar hook capping protein BS11774_14750 ENOG4108JQA flagellar BS11774_14755 ENOG41068WV flagellar FlbD family protein BS11774_14765 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BS11774_14770 ENOG4105DD5 Flagellar motor switch protein BS11774_14775 ENOG4107YTP response regulator receiver protein BS11774_14785 ENOG4105CN7 Flagellar biosynthetic protein FliP BS11774_14790 ENOG4105VS8 Flagellar biosynthetic protein fliq BS11774_14795 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BS11774_14800 ENOG4105D00 flagellar biosynthetic protein flhB BS11774_14805 ENOG4105D7B Flagellar biosynthesis protein flha BS11774_14810 ENOG4105FZW flagellar biosynthesis regulator FlhF BS11774_14820 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BS11774_14825 ENOG4105CBS Chea signal transduction histidine kinase BS11774_14830 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BS11774_14845 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS11774_14855 ENOG4105CE9 30S ribosomal protein S2 BS11774_14860 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BS11774_14870 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BS11774_14875 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BS11774_14880 ENOG4105KNE Phosphatidate cytidylyltransferase BS11774_14890 ENOG4105DZP Membrane-associated zinc metalloprotease BS11774_14895 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BS11774_14900 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BS11774_14905 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BS11774_14910 ENOG4105CHV Transcription elongation factor NusA BS11774_14915 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BS11774_14920 ENOG4105VHM ribosomal protein BS11774_14925 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BS11774_14930 ENOG4105W7A Protein of unknown function (DUF503) BS11774_14935 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BS11774_14940 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BS11774_14945 ENOG4105DTN riboflavin biosynthesis protein ribF BS11774_14950 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BS11774_14955 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BS11774_14965 ENOG4105C1V Peptidase, M16 BS11774_14975 ENOG4105E35 Dipicolinate synthase subunit A BS11774_14980 ENOG4108S0H Dipicolinic acid synthetase, b subunit BS11774_14985 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BS11774_14995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS11774_15005 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BS11774_15015 ENOG4105CNU cell division protein FtsK BS11774_15020 ENOG4105FDP GntR family transcriptional regulator BS11774_15040 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BS11774_15045 ENOG4105XZV Protein of unknown function (DUF3243) BS11774_15060 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BS11774_15065 ENOG4105CEV competence damage-inducible protein BS11774_15075 ENOG4108A04 Beta-lactamase BS11774_15080 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BS11774_15085 ENOG4105D48 metallophosphoesterase BS11774_15090 ENOG4105MCT stage V sporulation protein S BS11774_15100 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BS11774_15105 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BS11774_15120 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BS11774_15125 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BS11774_15135 ENOG4105IIP Membrane BS11774_15140 ENOG4105W1N transcriptional regulator BS11774_15165 ENOG4105K7W phage-related replication protein BS11774_15170 ENOG4108X3M OsmC Ohr family protein BS11774_15175 ENOG410814C multidrug resistance protein BS11774_15195 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BS11774_15200 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BS11774_15215 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BS11774_15220 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS11774_15225 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS11774_15230 ENOG4105U6W MutT NUDIX family protein BS11774_15235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS11774_15245 ENOG4106F1P AAA ATPase, central domain protein BS11774_15250 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BS11774_15255 ENOG4105CXI aluminum resistance protein BS11774_15260 ENOG4105KV4 Transcriptional regulator BS11774_15265 ENOG4105C5F glutamine synthetase BS11774_15355 ENOG410907G BS11774_15360 ENOG4105CT4 transporter BS11774_15365 ENOG4105DSG hydrolase family 43 BS11774_15370 ENOG4105E2R ROK family BS11774_15375 ENOG4105C93 Xylose Isomerase BS11774_15380 ENOG4105CMG Carbohydrate kinase BS11774_15390 ENOG4107Y9E nuclease BS11774_15395 ENOG4105C54 Major Facilitator superfamily BS11774_15400 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BS11774_15415 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BS11774_15490 ENOG4108NHD germination protein BS11774_15505 ENOG4105FVX BS11774_15515 ENOG4105K7W phage-related replication protein BS11774_15535 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BS11774_15545 ENOG4108SVB resolvase BS11774_15550 ENOG4105VPS UPF0291 protein BS11774_15555 ENOG4105CV1 Transketolase (EC 2.2.1.1) BS11774_15575 ENOG4107QIV Cytochrome c biogenesis protein BS11774_15605 ENOG4107DZX Small, acid-soluble spore protein P BS11774_15615 ENOG4108I0Z Aconitate hydratase BS11774_15620 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS11774_15635 ENOG41067CD Small, acid-soluble spore protein Tlp BS11774_15645 ENOG4105MI2 BS11774_15650 ENOG4105W8X HesB YadR YfhF-family protein BS11774_15655 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BS11774_15660 ENOG4105K4P CoA-binding domain protein BS11774_15665 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS11774_15700 ENOG4107SYN Glycosyl hydrolases family 43 BS11774_15710 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS11774_15715 ENOG4107T5V SNARE associated Golgi BS11774_15725 ENOG4107QX3 carboxylase BS11774_15730 ENOG4105E39 Enoyl-CoA hydratase BS11774_15735 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BS11774_15740 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BS11774_15745 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BS11774_15750 ENOG4105CEY Amp-dependent synthetase and ligase BS11774_15755 ENOG4105C1G acyl-Coa dehydrogenase BS11774_15765 ENOG4105F32 YngK protein BS11774_15770 ENOG4106U2H Protein of unknown function (DUF1360) BS11774_15785 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BS11774_15790 ENOG4108N2V aldose 1-epimerase BS11774_15795 ENOG4107QJQ Mate efflux family protein BS11774_15820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BS11774_15825 ENOG4105SKE transcriptional Regulator LysR family BS11774_15830 ENOG4105CB2 alcohol dehydrogenase BS11774_15835 ENOG4105BZ8 glutamate synthase BS11774_15840 ENOG4105CBC glutamate synthase BS11774_15845 ENOG4105C5Q Transcriptional regulator BS11774_15850 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BS11774_15855 ENOG4105II7 pyrroline-5-carboxylate reductase BS11774_15875 ENOG4108UB7 BS11774_15880 ENOG41068WN BS11774_15890 ENOG4107U6E carbohydrate kinase FGGY BS11774_15935 ENOG4106ANW SMI1_KNR4 BS11774_15940 ENOG4106BHF BS11774_15970 ENOG4108YQE rare lipoprotein a BS11774_15975 ENOG4105XPP Protein of unknown function (DUF1275) BS11774_15980 ENOG4108NR7 pectate lyase BS11774_15985 ENOG4108RAV Conserved protein BS11774_15995 ENOG4105F0F Oxalate decarboxylase BS11774_16020 ENOG41073R8 VanW family BS11774_16030 ENOG4105VMP Transcriptional regulator BS11774_16055 ENOG4108V4B ThiJ pfpI BS11774_16060 ENOG4108J4B Beta-lactamase BS11774_16080 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BS11774_16085 ENOG4107T94 Endo-14-beta-xylanase BS11774_16095 ENOG4105YB8 TM2 domain containing protein BS11774_16100 ENOG4108IMY Transcriptional regulator BS11774_16160 ENOG4105D9U N-acetyltransferase BS11774_16170 ENOG4105D06 uba thif-type nad fad binding protein BS11774_16175 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BS11774_16195 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS11774_16220 ENOG4105UA4 acetyltransferase BS11774_16235 ENOG4106ANW SMI1_KNR4 BS11774_16240 ENOG4106BHF BS11774_16255 ENOG4108Z7R Chaperone CsaA BS11774_16260 ENOG4105FTV AraC Family Transcriptional Regulator BS11774_16265 ENOG4108HJF gCN5-related N-acetyltransferase BS11774_16275 ENOG4108W8B Beta-lactamase domain protein BS11774_16285 ENOG4105D29 Helix-turn-helix type 11 domain protein BS11774_16295 ENOG4105KTU Transcriptional regulator, arsr family BS11774_16305 ENOG4108SJC Membrane BS11774_16325 ENOG4105ECK Fatty Acid Desaturase BS11774_16330 ENOG4108ZGX Histidine kinase BS11774_16335 ENOG4108S01 response regulator BS11774_16340 ENOG41069ER domain protein BS11774_16345 ENOG4105C9U ATP-dependent DNA helicase RecQ BS11774_16360 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BS11774_16365 ENOG4105SCY DNAK suppressor BS11774_16405 ENOG4105C26 Dehydrogenase BS11774_16410 ENOG4105EWU Squalene--hopene cyclase BS11774_16420 ENOG4105C8J )-transporter BS11774_16425 ENOG4105C09 Bile acid BS11774_16430 ENOG4105C7S Dehydrogenase BS11774_16440 ENOG4107T89 von Willebrand factor, type A BS11774_16445 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BS11774_16455 ENOG4105K4H Nlp p60 protein BS11774_16460 ENOG41087PP glycosyltransferase MGT family BS11774_16470 ENOG4107QMU Mate efflux family protein BS11774_16475 ENOG4106SCS STAS domain BS11774_16495 ENOG4105FR1 rard protein BS11774_16515 ENOG4105C6Z Gluconate BS11774_16520 ENOG41090U3 tautomerase BS11774_16535 ENOG4105FBA Phospholipase Carboxylesterase BS11774_16550 ENOG4105E1V na solute symporter BS11774_16570 ENOG4108VXD carboxy-peptidase BS11774_16575 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BS11774_16585 ENOG4106Z5R BS11774_16590 ENOG410841Q phosphoesterase PA-phosphatase related protein BS11774_16635 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BS11774_16670 ENOG41068G1 BS11774_16720 ENOG4105E4C Lytic transglycosylase catalytic BS11774_16745 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BS11774_16765 ENOG4107R0E Glycosyl transferase, family 2 BS11774_16790 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS11774_16810 ENOG4106BHF BS11774_16830 ENOG4107Y9E nuclease BS11774_16855 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BS11774_16860 ENOG4108TSC N-acetyltransferase BS11774_16865 ENOG4107S4Y M20 DapE family protein YgeY BS11774_16880 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS11774_16915 ENOG4107T32 3-phytase (EC 3.1.3.8) BS11774_16920 ENOG4105C5E polysaccharide biosynthesis protein BS11774_16925 ENOG4105E0X reductase BS11774_16930 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BS11774_16950 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BS11774_16955 ENOG41090WU lipolytic protein G-D-S-L family BS11774_16960 ENOG4108KF3 Electron transport protein SCO1 SenC BS11774_16970 ENOG4105C7B Threonine dehydratase BS11774_16980 ENOG4108UT2 hemolysin iii BS11774_16990 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BS11774_17005 ENOG4107YX5 Pfam:DUF548 BS11774_17010 ENOG4108Y6J UPF0403 protein BS11774_17015 ENOG4105C01 Dihydroxy-acid dehydratase BS11774_17030 ENOG4108V06 Glutathione peroxidase BS11774_17035 ENOG4105CVG Homoserine O-transsuccinylase BS11774_17075 ENOG41081VK Ribonuclease BS11774_17100 ENOG410890F Dynamin family BS11774_17115 ENOG41065KQ synthase BS11774_17120 ENOG4105C2W permease BS11774_17125 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BS11774_17130 ENOG4105CTD carboxy-peptidase BS11774_17135 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BS11774_17140 ENOG4108UHU Aldolase BS11774_17145 ENOG4105D7K pfkb domain protein BS11774_17150 ENOG4108M60 Transcriptional regulator BS11774_17160 ENOG4105CHR reductase BS11774_17165 ENOG4105DVT helicase BS11774_17180 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BS11774_17195 ENOG4108UKS UPF0398 protein BS11774_17205 ENOG4107X2U Inherit from COG: Exonuclease-like protein BS11774_17210 ENOG4108I5C dEAD DEAH box helicase BS11774_17260 ENOG4105BZ4 penicillin-binding protein BS11774_17270 ENOG4105CSM endonuclease III BS11774_17280 ENOG4105C5S asparaginyl-tRNA synthetase BS11774_17285 ENOG4105CHM Aminotransferase BS11774_17295 ENOG4105YAC BS11774_17300 ENOG4105DVT helicase BS11774_17305 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BS11774_17310 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BS11774_17315 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BS11774_17320 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BS11774_17325 ENOG4105DJ0 Poly(A) Polymerase BS11774_17330 ENOG4105CPK Glycosyl transferase (Group 1 BS11774_17335 ENOG4105FJR Lmbe family BS11774_17340 ENOG4108Z5K methylglyoxal synthase BS11774_17345 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BS11774_17350 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BS11774_17355 ENOG4108JYZ YitT family BS11774_17375 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BS11774_17395 ENOG41068YB TPR repeat-containing protein BS11774_17400 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BS11774_17410 ENOG4105CIH Imidazole acetol-phosphate transaminase BS11774_17420 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BS11774_17425 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BS11774_17435 ENOG4108I0Q anthranilate phosphoribosyltransferase BS11774_17440 ENOG4105CRQ synthase (Component I) BS11774_17445 ENOG4105KHN chorismate mutase BS11774_17450 ENOG4105D49 3-dehydroquinate synthase BS11774_17455 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BS11774_17460 ENOG4105BZU Histidine kinase BS11774_17465 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BS11774_17470 ENOG4105EAH synthase BS11774_17475 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BS11774_17480 ENOG4105XXQ heptaprenyl diphosphate synthase component I BS11774_17490 ENOG4105EUJ GTP cyclohydrolase i BS11774_17495 ENOG4105K70 DNA-binding protein BS11774_17500 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BS11774_17515 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BS11774_17520 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BS11774_17525 ENOG41065D1 BS11774_17530 ENOG4105S2F BS11774_17545 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BS11774_17550 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BS11774_17555 ENOG4105CAT Cytidine monophosphate kinase BS11774_17570 ENOG4105MSI germination protein ypeb BS11774_17580 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BS11774_17585 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BS11774_17600 ENOG4107RGJ metallophosphoesterase BS11774_17615 ENOG4105I7S Abortive infection protein BS11774_17620 ENOG4105C9U ATP-dependent DNA helicase RecQ BS11774_17625 ENOG4105T7X BS11774_17635 ENOG4108SAX Membrane BS11774_17640 ENOG4108JQ1 Dehydrogenase BS11774_17650 ENOG4105FF2 Type I DHQase BS11774_17665 ENOG4105BZU Histidine kinase BS11774_17670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS11774_17675 ENOG4105CRE cytochrome C BS11774_17680 ENOG4107TWT Cytochrome c biogenesis protein BS11774_17690 ENOG4105FE9 pseudouridine synthase BS11774_17700 ENOG4108JIC nucleoside recognition domain protein BS11774_17705 ENOG4105DZ1 carboxypeptidase BS11774_17715 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BS11774_17720 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BS11774_17735 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BS11774_17740 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BS11774_17745 ENOG4108R6K riboflavin synthase, subunit alpha BS11774_17750 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BS11774_17760 ENOG4105C3F Signal peptidase i BS11774_17775 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BS11774_17805 ENOG4107ZE5 PPIases accelerate the folding of proteins BS11774_17815 ENOG4105PTM secreted protein BS11774_17820 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BS11774_17830 ENOG4105G6R Stage v sporulation protein ae BS11774_17840 ENOG4105CZ3 stage V sporulation protein ad BS11774_17845 ENOG41090VF Stage v sporulation protein ac BS11774_17860 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS11774_17865 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BS11774_17870 ENOG41082AN stage II sporulation protein BS11774_17875 ENOG4105DZ1 carboxypeptidase BS11774_17880 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BS11774_17885 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BS11774_17890 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS11774_17900 ENOG4105I3K Ferric uptake regulator, Fur family BS11774_17905 ENOG4105MZ9 stage II sporulation protein m BS11774_17920 ENOG4105DFD Na H antiporter BS11774_17925 ENOG4108IJ0 Aspartate ammonia-lyase BS11774_17930 ENOG4105HDK L-asparaginase BS11774_17935 ENOG4108IMY Transcriptional regulator BS11774_17945 ENOG4108YZ4 nudix hydrolase BS11774_17955 ENOG4105CPC Aldo Keto reductase BS11774_17975 ENOG4106HZJ BS11774_17980 ENOG4105RHY Pfam:UPF0157 BS11774_17985 ENOG4105KAC Antibiotic biosynthesis monooxygenase BS11774_17990 ENOG4108XET gCN5-related N-acetyltransferase BS11774_18000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS11774_18010 ENOG4105E5W Transporter BS11774_18020 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BS11774_18035 ENOG4108IXY short-chain dehydrogenase reductase BS11774_18040 ENOG41069FQ Metallo-beta-lactamase superfamily BS11774_18045 ENOG4105II7 pyrroline-5-carboxylate reductase BS11774_18055 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS11774_18070 ENOG410861F 50S ribosomal protein L33 BS11774_18075 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BS11774_18080 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BS11774_18085 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BS11774_18090 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS11774_18100 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BS11774_18105 ENOG4108NA0 Uncharacterized conserved protein (COG2071) BS11774_18110 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BS11774_18115 ENOG4108HNZ carboxyl transferase BS11774_18120 ENOG4108ZVT methylmalonyl-coA epimerase BS11774_18125 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BS11774_18130 ENOG4108QEG Membrane BS11774_18135 ENOG4105CDA abc transporter atp-binding protein BS11774_18140 ENOG4105E5Q amino acid AbC transporter BS11774_18145 ENOG4108HW3 (ABC) transporter BS11774_18150 ENOG4108Y6J UPF0403 protein BS11774_18155 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BS11774_18170 ENOG4105C7S Dehydrogenase BS11774_18175 ENOG4105CPP Dehydrogenase, E1 component BS11774_18190 ENOG4105CKM Branched-chain carboxylic acid kinase BS11774_18195 ENOG4107RDP Dehydrogenase BS11774_18205 ENOG4108JUB Transcriptional regulator BS11774_18210 ENOG4106CCJ Protein of unknown function (DUF2627) BS11774_18215 ENOG4105CR4 methylisocitrate lyase BS11774_18220 ENOG4105DXD 2-methylcitrate dehydratase BS11774_18230 ENOG4105C1G acyl-Coa dehydrogenase BS11774_18235 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BS11774_18245 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BS11774_18250 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS11774_18260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS11774_18265 ENOG4107QQR Sporulation BS11774_18275 ENOG4105S1Z Stage IV sporulation protein B BS11774_18280 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BS11774_18285 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BS11774_18290 ENOG4105DX0 Hemolysin A BS11774_18300 ENOG4105CTB Polyprenyl synthetase BS11774_18305 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BS11774_18310 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BS11774_18315 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BS11774_18320 ENOG4105M7K Involved in the transcription termination process (By similarity) BS11774_18325 ENOG4108ZSR alkaline shock protein BS11774_18330 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BS11774_18350 ENOG410644B Stage III sporulation protein af BS11774_18360 ENOG4105KQ4 Stage iii sporulation protein ad BS11774_18365 ENOG4108CQH stage III sporulation protein AC BS11774_18370 ENOG4105KR5 Stage iii sporulation protein BS11774_18375 ENOG4105CD2 stage iii sporulation protein aa BS11774_18385 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BS11774_18390 ENOG4105DC7 peptidase M24 BS11774_18395 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BS11774_18405 ENOG4105CBJ Metal-dependent enzyme BS11774_18420 ENOG4105KST dependent repressor BS11774_18425 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BS11774_18430 ENOG4105WZW rhodanese family BS11774_18435 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BS11774_18440 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BS11774_18445 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BS11774_18450 ENOG4105C0D helicase BS11774_18465 ENOG4108IMY Transcriptional regulator BS11774_18475 ENOG4105VFR signal peptidase BS11774_18530 ENOG41080XP Cbs domain BS11774_18540 ENOG4105C37 (CBS) domain BS11774_18565 ENOG4105C5X domain protein BS11774_18590 ENOG4105E0M Sulfatase BS11774_18605 ENOG4107ZXI Rhomboid family BS11774_18615 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BS11774_18620 ENOG4105WDJ 50S ribosomal protein L33 BS11774_18640 ENOG41068DG YceG-like family BS11774_18645 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BS11774_18650 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BS11774_18655 ENOG4105E2Z phosphate ABC transporter (Permease BS11774_18660 ENOG4105C8U phosphate abc transporter BS11774_18665 ENOG4105CVA phosphate BS11774_18670 ENOG4107RF6 penicillin-binding protein BS11774_18680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BS11774_18685 ENOG4105SXS Protein of unknown function (DUF456) BS11774_18700 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BS11774_18705 ENOG41063Y9 BS11774_18710 ENOG4108U5J '-nucleotidase BS11774_18715 ENOG4105N80 Ferric uptake regulator, Fur family BS11774_18720 ENOG4108JYZ YitT family BS11774_18725 ENOG41069ZM Protein of unknown function (DUF2624) BS11774_18730 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BS11774_18745 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BS11774_18750 ENOG4105EGD dinuclear metal center protein, YbgI family BS11774_18770 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS11774_18775 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BS11774_18780 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 BS11774_18785 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BS11774_18795 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BS11774_18800 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BS11774_18805 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BS11774_18815 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BS11774_18820 ENOG4105KG3 cytidine deaminase BS11774_18825 ENOG4107YR5 Diacylglycerol kinase BS11774_18830 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BS11774_18835 ENOG4105CTJ Metal Dependent Phosphohydrolase BS11774_18840 ENOG4105C9A Phoh family BS11774_18845 ENOG4105EI1 sporulation protein yqfd BS11774_18850 ENOG41068P3 sporulation protein YqfC BS11774_18860 ENOG4105DI5 UPF0365 protein BS11774_18865 ENOG4105F7J membrane-bound serine protease BS11774_18870 ENOG4105KTH gatB Yqey BS11774_18885 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BS11774_18890 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BS11774_18895 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BS11774_18905 ENOG4105CFG Acts as a chaperone (By similarity) BS11774_18910 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BS11774_18915 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BS11774_18920 ENOG4105CSA Coproporphyrinogen iii oxidase BS11774_18925 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BS11774_18935 ENOG4108ZRV stage ii sporulation protein p BS11774_18940 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BS11774_18945 ENOG41082YS Binds directly to 16S ribosomal RNA BS11774_18950 ENOG4105TQK DNA polymerase iii, delta' subunit BS11774_18960 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BS11774_18965 ENOG4108UK2 deaminase BS11774_18970 ENOG4105KQC Competence protein BS11774_18980 ENOG4108D32 Methyltransferase BS11774_18990 ENOG4108WF2 Metal Dependent Phosphohydrolase BS11774_18995 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BS11774_19000 ENOG410812S Rna-binding protein BS11774_19005 ENOG4105E2X shikimate dehydrogenase BS11774_19010 ENOG4105CQW ribosome biogenesis GTPase YqeH BS11774_19015 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BS11774_19030 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BS11774_19035 ENOG41080BT SNARE associated Golgi BS11774_19060 ENOG4107Y5K Resolvase BS11774_19085 ENOG4108UXE Protein tyrosine phosphatase BS11774_19090 ENOG4105D6J arsenicaL-resistance protein BS11774_19095 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BS11774_19100 ENOG41085FC arsR family transcriptional regulator BS11774_19140 ENOG41064HX Suppressor of fused protein (SUFU) BS11774_19155 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BS11774_19190 ENOG410906S phage-like element pbsx protein xkdt BS11774_19195 ENOG41066EA baseplate J family protein BS11774_19200 ENOG4105MFU Protein of unknown function (DUF2634) BS11774_19210 ENOG4105X7F BS11774_19215 ENOG4108WZM domain protein BS11774_19220 ENOG4108FKH Transglycosylase SLT domain BS11774_19230 ENOG4105MTC XkdN-like protein BS11774_19235 ENOG4105FR7 XkdM protein, phage-like element PBSX BS11774_19240 ENOG4105PQS phage protein BS11774_19255 ENOG41060SN BS11774_19290 ENOG4106CGH Phage Mu protein F like protein BS11774_19295 ENOG4108MDF Phage Portal Protein BS11774_19300 ENOG4105IG6 Phage terminase, large subunit BS11774_19340 ENOG4105QBX endodeoxyribonuclease RusA BS11774_19360 ENOG4108PNI recT protein BS11774_19365 ENOG4108NF7 phage-type endonuclease BS11774_19390 ENOG4106A7E Transcriptional regulator BS11774_19395 ENOG41067QW Transcriptional regulator BS11774_19420 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BS11774_19445 ENOG4105D3P Mannan endo-1,4-beta-mannosidase BS11774_19450 ENOG41087NI Sulfite exporter TauE/SafE BS11774_19455 ENOG4105VFE sira family BS11774_19460 ENOG4107TPS domain protein BS11774_19470 ENOG4105VFE sira family BS11774_19475 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BS11774_19480 ENOG4105XTG Pfam:DUF156 BS11774_19495 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BS11774_19510 ENOG41090E6 transcriptional regulator MERR family BS11774_19525 ENOG4105C37 (CBS) domain BS11774_19540 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family BS11774_19545 ENOG4105H3G oxidoreductase BS11774_19550 ENOG4105PGM cation diffusion facilitator family transporter BS11774_19565 ENOG4105KMT branched-chain amino acid BS11774_19570 ENOG4108UMN azlc family BS11774_19575 ENOG4108ZRZ Transcriptional regulator (AsnC family) BS11774_19600 ENOG41064BW Protein of unknown function (DUF2568) BS11774_19615 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BS11774_19620 ENOG4105EA8 2-Nitropropane dioxygenase BS11774_19635 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BS11774_19660 ENOG4105CPC Aldo Keto reductase BS11774_19670 ENOG4108KAM Transcriptional regulator BS11774_19675 ENOG4105C7F AcnD-accessory protein PrpF BS11774_19680 ENOG41083Q9 chitosanase BS11774_19685 ENOG4105X5K response regulator receiver protein BS11774_19690 ENOG4108VQT Alpha beta hydrolase fold protein BS11774_19695 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BS11774_19700 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein BS11774_19715 ENOG4105PGS Spore coat protein BS11774_19720 ENOG4105E2A Dehydrogenase BS11774_19735 ENOG4105VUF Transcriptional regulator BS11774_19745 ENOG4105DQ4 alcohol dehydrogenase BS11774_19750 ENOG4108Z0Z intracellular protease Pfpi family BS11774_19755 ENOG4108HKT sucrose-6-phosphate hydrolase BS11774_19760 ENOG4105F3R pts system mannose fructose sorbose family iid BS11774_19765 ENOG4105ETZ PTS System BS11774_19770 ENOG4108IQ3 PTS system BS11774_19775 ENOG4105YHU PTS system BS11774_19780 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BS11774_19785 ENOG4105C85 amino acid BS11774_19790 ENOG4105N14 lysine exporter protein LysE YggA BS11774_19795 ENOG4108NGU Transcriptional regulator BS11774_19830 ENOG4105JVQ RNA Polymerase BS11774_19835 ENOG4108P49 AntiSigma factor BS11774_19840 ENOG4105EXC Acyl-transferase BS11774_19845 ENOG4105WDR BS11774_19865 ENOG4105TMB Formate nitrite transporter BS11774_19870 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BS11774_19875 ENOG4108JB9 formate dehydrogenase BS11774_19890 ENOG4105C28 cystathionine BS11774_19905 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BS11774_19920 ENOG4107XRG penicillin-binding protein BS11774_19925 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BS11774_19930 ENOG4105DBI uridine monophosphokinase BS11774_19935 ENOG4105CFP Peptidase U32 BS11774_19940 ENOG4105XYU peptidase (U32 family) BS11774_19945 ENOG4108VQJ O-methyltransferase BS11774_19950 ENOG4105HHA aminodeoxychorismate lyase BS11774_19955 ENOG4105VPH UPF0473 protein BS11774_19960 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BS11774_19965 ENOG4105VBH UPF0297 protein BS11774_19970 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BS11774_19975 ENOG4105C02 permease BS11774_19980 ENOG4105CDA abc transporter atp-binding protein BS11774_19985 ENOG4105CT1 (ABC) transporter BS11774_19990 ENOG4105EAD ABC transporter BS11774_19995 ENOG4105DRP amino acid AbC transporter BS11774_20005 ENOG41060CR BS11774_20015 ENOG4105C7H Helicase, RecD TraA family BS11774_20025 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BS11774_20030 ENOG4105C3J Cysteine desulfurase BS11774_20040 ENOG4105D1H recombination factor protein RarA BS11774_20045 ENOG4105CUZ uba thif-type nad fad binding protein BS11774_20055 ENOG4105C9M aspartyl-trna synthetase BS11774_20060 ENOG4105CUT histidyl-tRNA synthetase BS11774_20070 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS11774_20080 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BS11774_20085 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BS11774_20090 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BS11774_20095 ENOG41067VP Protein of unknown function (DUF1049) BS11774_20100 ENOG4105NCW Trka-c domain protein BS11774_20105 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BS11774_20115 ENOG4105CKP Polysaccharide Biosynthesis Protein BS11774_20120 ENOG4108QG2 Membrane BS11774_20125 ENOG4105NAP BS11774_20130 ENOG4105VIE preprotein translocase, subunit YajC BS11774_20135 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BS11774_20140 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BS11774_20145 ENOG41061AI Protein of unknown function (DUF2905) BS11774_20150 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BS11774_20155 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BS11774_20165 ENOG4105IE8 Alpha-ketoglutarate permease BS11774_20170 ENOG4105CK5 oxidoreductase BS11774_20190 ENOG4105BZG amino acid carrier protein BS11774_20195 ENOG4105CDY transcriptional regulatory protein BS11774_20205 ENOG4106678 morphogenetic protein associated with SpoVID BS11774_20210 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BS11774_20215 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BS11774_20220 ENOG4108IYU L-aspartate oxidase BS11774_20235 ENOG4105CQC Prephenate dehydratase BS11774_20240 ENOG41090I5 UPF0735 ACT domain-containing protein BS11774_20245 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BS11774_20255 ENOG4105K46 50S ribosomal protein l27 BS11774_20260 ENOG4105X36 (ribosomal) protein BS11774_20265 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BS11774_20280 ENOG4107QMS site-determining protein BS11774_20285 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BS11774_20290 ENOG4105YHC Rod shape-determining protein MreD BS11774_20295 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BS11774_20300 ENOG4105DFF Rod shape-determining protein mreb BS11774_20305 ENOG4105W5Q DNA repair protein (RadC BS11774_20310 ENOG4108Z03 MAF-like protein BS11774_20320 ENOG4106A3R peptidase BS11774_20325 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BS11774_20330 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BS11774_20340 ENOG4106AR7 Spore coat protein BS11774_20345 ENOG41068KH stage VI sporulation protein D BS11774_20350 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BS11774_20355 ENOG4105D52 delta-aminolevulinic acid dehydratase BS11774_20365 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BS11774_20375 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BS11774_20385 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BS11774_20390 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BS11774_20395 ENOG4108IUQ atp-dependent protease BS11774_20400 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BS11774_20405 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BS11774_20415 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BS11774_20420 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BS11774_20425 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS11774_20430 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BS11774_20435 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BS11774_20440 ENOG4108ZP8 Acetolactate synthase small subunit BS11774_20445 ENOG4105C7K acetolactate synthase BS11774_20460 ENOG4107KM7 Heat induced stress protein YflT BS11774_20470 ENOG4105M59 Phosphodiesterase, mj0936 family BS11774_20475 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BS11774_20480 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BS11774_20485 ENOG4108XJQ germination protein BS11774_20490 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BS11774_20495 ENOG41067TZ transcriptional regulator, MarR family BS11774_20500 ENOG4105PFC Transcriptional regulator BS11774_20510 ENOG4105E33 succinate dehydrogenase BS11774_20520 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BS11774_20530 ENOG4105CFH Aspartokinase BS11774_20540 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BS11774_20545 ENOG4105K63 Thioredoxin BS11774_20555 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BS11774_20560 ENOG4105C10 Electron transfer flavoprotein BS11774_20565 ENOG4105BZJ Electron transfer flavoprotein BS11774_20570 ENOG41060WC Enoyl-CoA hydratase BS11774_20575 ENOG4107Z3H Transcriptional regulator, TetR family BS11774_20580 ENOG4105CEY Amp-dependent synthetase and ligase BS11774_20590 ENOG4105C98 muts2 protein BS11774_20595 ENOG4105DCG PHP domain protein BS11774_20610 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BS11774_20615 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BS11774_20620 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BS11774_20630 ENOG4108RWN rrna methyltransferase BS11774_20635 ENOG41067MF small acid-soluble spore protein BS11774_20645 ENOG4105CQB FAD linked oxidase domain protein BS11774_20650 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BS11774_20670 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BS11774_20675 ENOG4105DRS transport system, permease BS11774_20690 ENOG4108MDK Dehydrogenase BS11774_20700 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BS11774_20705 ENOG4105EF1 ribulokinase BS11774_20720 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BS11774_20725 ENOG4105CN9 Peptidase m42 family protein BS11774_20735 ENOG410696E Membrane BS11774_20740 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BS11774_20745 ENOG4105VJV 50s ribosomal protein L35 BS11774_20750 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BS11774_20760 ENOG41067MG lrgb family BS11774_20770 ENOG4105DY9 regulatoR BS11774_20775 ENOG4108HRK Histidine kinase BS11774_20780 ENOG4105U0R haloacid dehalogenase-like hydrolase BS11774_20785 ENOG4105C22 threonyL-tRNA synthetase BS11774_20790 ENOG4108TDW sporulation protein YtxC BS11774_20810 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BS11774_20815 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BS11774_20820 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BS11774_20825 ENOG4105KVH Transcriptional regulator BS11774_20830 ENOG4105F27 Major Facilitator BS11774_20835 ENOG4105CV8 reductase BS11774_20840 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BS11774_20850 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BS11774_20855 ENOG4105C2M dna polymerase I BS11774_20860 ENOG4105BZU Histidine kinase BS11774_20865 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS11774_20870 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BS11774_20875 ENOG4108HMX isocitrate dehydrogenase (NADP) BS11774_20880 ENOG4105BZN citrate synthase BS11774_20890 ENOG4108REF Sporulation integral membrane protein ytvi BS11774_20895 ENOG4105FS0 cytoplasmic membrane protein BS11774_20900 ENOG4105CA9 Pyruvate kinase BS11774_20905 ENOG4105CTQ phosphohexokinase BS11774_20915 ENOG4108IEY Carboxyl transferase domain BS11774_20920 ENOG4105C6K Malic enzyme BS11774_20925 ENOG4105C0B DNA polymerase III (alpha subunit) BS11774_20930 ENOG4105VV2 BS11774_20940 ENOG4106EVM BS11774_20945 ENOG4105SFS phosphoesterase RecJ domain protein BS11774_20960 ENOG410635A Membrane BS11774_20965 ENOG4105CH2 amidohydrolase BS11774_20985 ENOG4105DEN Luciferase family BS11774_20990 ENOG4105CDA abc transporter atp-binding protein BS11774_21015 ENOG4108XSB acetyltransferase, (GNAT) family BS11774_21020 ENOG4108KSA LysR family transcriptional regulator BS11774_21025 ENOG4105E8R UPF0173 metal-dependent hydrolase BS11774_21040 ENOG4105CH7 arginosuccinase BS11774_21045 ENOG4105CDH Citrulline--aspartate ligase BS11774_21050 ENOG4105EPU Molybdenum cofactor synthesis domain protein BS11774_21055 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BS11774_21070 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BS11774_21075 ENOG4105KBJ sporulation protein ytfj BS11774_21085 ENOG4105VK3 rdd domain containing protein BS11774_21090 ENOG4105D07 Signal peptide peptidase, SppA BS11774_21095 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BS11774_21100 ENOG4105EFZ amidohydrolase BS11774_21105 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BS11774_21140 ENOG4105U5Y Transcriptional regulator BS11774_21165 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BS11774_21170 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BS11774_21185 ENOG4105F1V Acetoin utilization protein BS11774_21190 ENOG4105W87 Cbs domain BS11774_21195 ENOG4105DGU Histone deacetylase BS11774_21200 ENOG4105ER2 Ompa motb domain protein BS11774_21205 ENOG4107R0U MotA TolQ exbB proton channel BS11774_21210 ENOG4105ETE Transcriptional regulator (LacI family BS11774_21215 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BS11774_21235 ENOG4105DFU Cell wall formation (By similarity) BS11774_21245 ENOG4108VDD TRNA binding domain protein BS11774_21260 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BS11774_21275 ENOG4105C6K Malic enzyme BS11774_21280 ENOG4105C8F Beta-lactamase domain protein BS11774_21285 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BS11774_21295 ENOG4108V15 phosphotransferase enzyme family BS11774_21300 ENOG4108IUM Glycogen debranching enzyme BS11774_21315 ENOG4107F58 2'-5' rna ligase BS11774_21320 ENOG4105C6T cysteine synthase BS11774_21325 ENOG4107QSE Dipeptidase BS11774_21330 ENOG4105C7N Xanthine uracil vitamin C permease BS11774_21345 ENOG4105YW5 deoR family transcriptional regulator BS11774_21360 ENOG4105CBX hi0933 family BS11774_21365 ENOG4105C94 Transporter BS11774_21375 ENOG4105MU9 integral membrane protein BS11774_21380 ENOG4105DDC Oxidoreductase domain protein BS11774_21390 ENOG4105F5H Glycosyl Hydrolase Family 88 BS11774_21400 ENOG41075H3 AraC family transcriptional regulator BS11774_21410 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BS11774_21420 ENOG4106A3M Cytochrome p-450 BS11774_21425 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BS11774_21435 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BS11774_21440 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS11774_21455 ENOG4105NTD Inherit from COG: Hydrolase BS11774_21470 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BS11774_21475 ENOG4105I1K ABC transporter BS11774_21485 ENOG41085GJ domain protein BS11774_21490 ENOG4105C8T Leucyl-tRNA synthetase BS11774_21500 ENOG4105BZU Histidine kinase BS11774_21510 ENOG410605W Major Facilitator BS11774_21515 ENOG4106UBQ BS11774_21525 ENOG4105C19 ABC transporter BS11774_21530 ENOG4105EWM Histidine kinase BS11774_21540 ENOG4107R34 abc transporter permease protein BS11774_21545 ENOG4105C19 ABC transporter BS11774_21560 ENOG4105DVE abc transporter atp-binding protein BS11774_21565 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BS11774_21575 ENOG4105N5T Radical SAM Protein BS11774_21590 ENOG4105E8V Alpha Beta Hydrolase Fold protein BS11774_21595 ENOG4108Z0R Transferase BS11774_21600 ENOG4105C85 amino acid BS11774_21605 ENOG4105CAQ asparagine synthetase BS11774_21610 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BS11774_21615 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BS11774_21630 ENOG4105D2X ABC transporter substrate-binding protein BS11774_21640 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BS11774_21655 ENOG4108RMU ferritin dps family protein BS11774_21670 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BS11774_21675 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BS11774_21680 ENOG4108V2W Carbonate dehydratase BS11774_21705 ENOG4105CC5 ABC transporter BS11774_21710 ENOG4105CC5 ABC transporter BS11774_21715 ENOG4105DIK (ABC) transporter BS11774_21720 ENOG4105DSE periplasmic solute binding protein BS11774_21725 ENOG4105DTQ mandelate racemase muconate lactonizing BS11774_21730 ENOG4105CEY Amp-dependent synthetase and ligase BS11774_21735 ENOG4108IPT Naphthoate synthase BS11774_21740 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BS11774_21745 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BS11774_21750 ENOG4105E4F Isochorismate synthase BS11774_21775 ENOG4108IAJ Nad-dependent epimerase dehydratase BS11774_21780 ENOG4107SBE Glycosyl transferase (Group 1 BS11774_21795 ENOG4107SBE Glycosyl transferase (Group 1 BS11774_21800 ENOG4108KS4 Spore coat protein