locus-tag class description KS08_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) KS08_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) KS08_00015 ENOG410848D S4 domain protein YaaA KS08_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) KS08_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KS08_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KS08_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) KS08_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) KS08_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) KS08_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) KS08_00095 ENOG4105BZW Glycerate kinase KS08_00105 ENOG4105ZMH deoxynucleoside kinase KS08_00115 ENOG4105VRS hydrolase family 18 KS08_00120 ENOG4105GTG Isochorismatase KS08_00125 ENOG4108Z6B deaminase KS08_00130 ENOG4105C6E dna polymerase iii KS08_00135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) KS08_00140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) KS08_00150 ENOG41067KS pro-sigma K processing KS08_00190 ENOG4105CDW Resistance protein KS08_00195 ENOG4105CXN decarboxylase KS08_00200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) KS08_00205 ENOG4105X0R protein from nitrogen regulatory protein P-II KS08_00210 ENOG4105XVJ Protein of unknown function (DUF327) KS08_00215 ENOG4105FA2 dna polymerase iii KS08_00220 ENOG4105MA4 psp1 domain protein KS08_00230 ENOG41060K3 Methyltransferase KS08_00235 ENOG4105VC4 domain protein KS08_00240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) KS08_00245 ENOG4105KRN Transcriptional regulator, abrb family KS08_00250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) KS08_00255 ENOG4105F8V Hydrolase, tatD family KS08_00260 ENOG41069ER domain protein KS08_00270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) KS08_00275 ENOG4105XFA sporulation peptidase YabG KS08_00280 ENOG4105W42 Veg protein KS08_00285 ENOG4105XEW small acid-soluble spore protein KS08_00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) KS08_00295 ENOG4105DFT pur operon repressor KS08_00300 ENOG4105KME endoribonuclease L-psp KS08_00305 ENOG4105K4W Could be involved in septation (By similarity) KS08_00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) KS08_00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase KS08_00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) KS08_00335 ENOG4108JA2 transcriptioN-repair coupling factor KS08_00340 ENOG4108M14 stage v sporulation protein t KS08_00350 ENOG4108IY2 MazG family KS08_00355 ENOG41082I2 s4 domain protein KS08_00360 ENOG4105VYY sporulation protein yabp KS08_00375 ENOG41060GV RNA binding s1 domain protein KS08_00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) KS08_00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase KS08_00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KS08_00420 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) KS08_00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) KS08_00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase KS08_00435 ENOG4105C6T cysteine synthase KS08_00440 ENOG4105CRQ synthase (Component I) KS08_00445 ENOG4105DDQ anthranilate synthase KS08_00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 KS08_00455 ENOG4105EEI dihydropteroate synthase KS08_00460 ENOG4105KRF dihydroneopterin aldolase KS08_00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase KS08_00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KS08_00480 ENOG4105CRK lysyL-tRNA synthetase KS08_00505 ENOG4108Z0C Uvrb UvrC protein KS08_00510 ENOG41066A3 ATP guanido phosphotransferase KS08_00520 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) KS08_00525 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) KS08_00530 ENOG4105CTP PilT protein domain protein KS08_00535 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) KS08_00540 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) KS08_00545 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) KS08_00555 ENOG4105D7W serine acetyltransferase KS08_00565 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) KS08_00570 ENOG4105C2N RNA methyltransferase TrmH family group 3 KS08_00575 ENOG4105M0M Tetracycline resistance protein KS08_00595 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KS08_00600 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) KS08_00610 ENOG4108VZM 50s ribosomal protein L10 KS08_00615 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) KS08_00620 ENOG4107Y49 methyltransferase KS08_00625 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KS08_00630 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KS08_00635 ENOG4105XPM ribosomal protein KS08_00640 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) KS08_00645 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) KS08_00650 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) KS08_00655 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) KS08_00660 ENOG4107SKW Inherit from COG: Alpha beta hydrolase KS08_00665 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) KS08_00670 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) KS08_00675 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) KS08_00680 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) KS08_00685 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity KS08_00690 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) KS08_00695 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) KS08_00700 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) KS08_00705 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) KS08_00710 ENOG41082SA 50s ribosomal protein l29 KS08_00715 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal KS08_00720 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) KS08_00730 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits KS08_00740 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) KS08_00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) KS08_00750 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) KS08_00755 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) KS08_00760 ENOG4105VPB 50S ribosomal protein L30 KS08_00765 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) KS08_00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KS08_00775 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KS08_00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KS08_00790 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) KS08_00800 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits KS08_00805 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) KS08_00810 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KS08_00815 ENOG4108ZT0 50S ribosomal protein l17 KS08_00820 ENOG4108JJB ABC transporter KS08_00825 ENOG4108JJB ABC transporter KS08_00830 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) KS08_00835 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) KS08_00840 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) KS08_00845 ENOG4108UJD 30S ribosomal protein S9 KS08_00850 ENOG4108I0C methyltransferase KS08_00865 ENOG4105D1F ATP-binding protein KS08_00880 ENOG4108NMV polysaccharide deacetylase KS08_00905 ENOG4108JPW Aminotransferase KS08_00915 ENOG4105CPQ Dehydrogenase KS08_00920 ENOG4105CHH sulfate transporter KS08_00930 ENOG4108SA1 esterase KS08_00950 ENOG410874W AraC family transcriptional regulator KS08_00955 ENOG4105EHZ conserved protein UCP016719 KS08_00960 ENOG4105D17 glycoside hydrolase, family 3 domain protein KS08_00975 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate KS08_00985 ENOG4105EWC Purine nucleoside phosphorylase KS08_01015 ENOG4105EMN RNA polymerase sigma factor KS08_01025 ENOG4105C8B TIGR00159 family KS08_01030 ENOG4107U5W ybbr family KS08_01035 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) KS08_01065 ENOG4106K80 KS08_01075 ENOG41067MG lrgb family KS08_01085 ENOG41061AU MarR family Transcriptional regulator KS08_01100 ENOG4105BZU Histidine kinase KS08_01105 ENOG4105WH1 Two component transcriptional regulator luxr family KS08_01110 ENOG4105CJ1 ABC, transporter KS08_01120 ENOG41090VJ ABC-2 type transporter KS08_01135 ENOG4106DDH Sporulation-specific SASP protein KS08_01150 ENOG4107QTZ amino acid KS08_01160 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KS08_01165 ENOG4105CXY transporter KS08_01190 ENOG4107SCQ Iron-containing alcohol dehydrogenase KS08_01195 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KS08_01200 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KS08_01205 ENOG4107ZTW SNARE associated Golgi KS08_01220 ENOG4105C72 UPF0176 protein KS08_01230 ENOG4105CM2 brancheD-chain amino acid aminotransferase KS08_01235 ENOG4108IQI permease KS08_01240 ENOG4108J5H Homocysteine s-methyltransferase KS08_01250 ENOG4105CSV Glutaminase KS08_01280 ENOG41076HS cation diffusion facilitator family transporter KS08_01285 ENOG4108TVJ Nitroreductase KS08_01290 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase KS08_01295 ENOG4108VGI doxx family KS08_01300 ENOG4105XXY Thioredoxin KS08_01320 ENOG4105DGI Alkaline phosphatase KS08_01325 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KS08_01330 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KS08_01335 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) KS08_01340 ENOG4107EPV Aminotransferase class V KS08_01345 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS08_01350 ENOG4105J7D transcriptional regulator KS08_01355 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold KS08_01360 ENOG41060AI SEC-C motif KS08_01365 ENOG4107SET aldo keto reductase KS08_01395 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KS08_01410 ENOG4105U3E Transcriptional regulator KS08_01415 ENOG4105DSE periplasmic solute binding protein KS08_01420 ENOG4105DIK (ABC) transporter KS08_01430 ENOG4105DEN Luciferase family KS08_01435 ENOG4108N0M stress protein KS08_01440 ENOG4106FN3 tellurium resistance protein KS08_01445 ENOG4106FN3 tellurium resistance protein KS08_01450 ENOG4107TS3 membrane protein, TerC KS08_01455 ENOG4108TTB tellurium resistance protein KS08_01465 ENOG41079KZ Major Facilitator Superfamily KS08_01470 ENOG4108IJ7 Glycine betaine KS08_01475 ENOG4107SQ8 Glycine betaine KS08_01505 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KS08_01535 ENOG4105EIG urea carboxylase-associated protein 1 KS08_01540 ENOG4107RA1 nh(3)-dependent nad( ) synthetase KS08_01545 ENOG4108WBH protein TIM barrel KS08_01550 ENOG4105DJB Major Facilitator Superfamily KS08_01555 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KS08_01560 ENOG4105I82 acetyl xylan esterase KS08_01565 ENOG410756H nucleotidyltransferase KS08_01575 ENOG4105C26 Dehydrogenase KS08_01580 ENOG4105CK7 Sodium proline symporter KS08_01585 ENOG4107YHD transcriptional regulator KS08_01590 ENOG4105CAY ferredoxin--nadp reductase KS08_01595 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KS08_01600 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit KS08_01605 ENOG4108IFG nitrite reductase, (NAD(P)H) KS08_01615 ENOG4105CKI cobalamin synthesis protein KS08_01620 ENOG4105E2A Dehydrogenase KS08_01625 ENOG4105HHM rdd domain containing protein KS08_01635 ENOG4105CS2 ec 3.2.1.21 KS08_01650 ENOG41080HJ 6-phospho 3-hexuloisomerase KS08_01655 ENOG4108VA3 3-hexulose-6-phosphate synthase KS08_01660 ENOG4105KVH Transcriptional regulator KS08_01670 ENOG4105CEY Amp-dependent synthetase and ligase KS08_01690 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) KS08_01705 ENOG4105CDA abc transporter atp-binding protein KS08_01710 ENOG4105DRP amino acid AbC transporter KS08_01720 ENOG4106P55 Transcriptional regulator KS08_01725 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase KS08_01730 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) KS08_01735 ENOG41069ZX KS08_01740 ENOG41069ZX KS08_01745 ENOG4105DUX Transporter KS08_01760 ENOG4105E1K spore germination protein KS08_01775 ENOG4105CPU Monooxygenase KS08_01780 ENOG4108XSB acetyltransferase, (GNAT) family KS08_01785 ENOG4105EAB amino acid AbC transporter KS08_01790 ENOG4108HW4 amino acid AbC transporter KS08_01800 ENOG4105CH2 amidohydrolase KS08_01805 ENOG4108PGP mmge prpd family protein KS08_01815 ENOG4107WD8 ABC transporter, permease KS08_01820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS08_01825 ENOG4105BZU Histidine kinase KS08_01845 ENOG4105CFH Aspartokinase KS08_01850 ENOG4105DHS permease protein KS08_01855 ENOG4105CM4 permease protein KS08_01860 ENOG4108IPW abc transporter atp-binding protein KS08_01875 ENOG4105R8C Transcriptional regulator KS08_01880 ENOG4108DBC nitroreductase KS08_01885 ENOG41067V3 Antibiotic biosynthesis monooxygenase KS08_01890 ENOG4105YVS arsR family transcriptional regulator KS08_01900 ENOG4108JPW Aminotransferase KS08_01905 ENOG4105C26 Dehydrogenase KS08_01915 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KS08_01920 ENOG4105KTB nuclear export factor GLE1 KS08_01925 ENOG4108T5E Copper resistance protein KS08_01930 ENOG4108ZYE Transcriptional regulator KS08_01950 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase KS08_01970 ENOG4105E7W lamb ycsf family protein KS08_01975 ENOG4105C5A transporter KS08_01980 ENOG4105CFM UPF0317 protein KS08_01985 ENOG4105P4J Allophanate hydrolase, subunit 1 KS08_01995 ENOG4107258 Transcriptional regulator KS08_02000 ENOG4105XJB lipolytic protein G-D-S-L family KS08_02010 ENOG41061CK Antibiotic biosynthesis monooxygenase KS08_02015 ENOG4107RVG penicillin-binding protein KS08_02020 ENOG4107QM2 Aldo Keto reductase KS08_02025 ENOG4105ETD TRANSCRIPTIONal KS08_02035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KS08_02050 ENOG410606W general stress protein KS08_02060 ENOG4105VCH membrane KS08_02070 ENOG4105C9U ATP-dependent DNA helicase RecQ KS08_02085 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) KS08_02100 ENOG4105C0X amino acid KS08_02115 ENOG41068KG domain protein KS08_02150 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) KS08_02165 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) KS08_02170 ENOG4105RXJ KS08_02175 ENOG4105KPY Small multidrug resistance protein KS08_02180 ENOG4105EU9 KS08_02185 ENOG4105QVS general stress protein KS08_02190 ENOG41082W1 Cupin 2, conserved barrel domain protein KS08_02205 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit KS08_02210 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism KS08_02215 ENOG4108MRH transcriptional regulatory protein KS08_02220 ENOG4107QJT sodium dicarboxylate symporter KS08_02225 ENOG4106F5Q Membrane KS08_02230 ENOG4105CJ1 ABC, transporter KS08_02245 ENOG4105FDT acyl-CoA dehydrogenase KS08_02265 ENOG4105SZ6 Thioredoxin KS08_02270 ENOG4105CPF Cell wall formation (By similarity) KS08_02275 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) KS08_02280 ENOG4105C1J atp-dependent rna helicase KS08_02285 ENOG410905X membrane-flanked domain protein KS08_02290 ENOG4105CKV Membrane KS08_02300 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) KS08_02305 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein KS08_02310 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KS08_02320 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) KS08_02325 ENOG4107MMM Anti-sigma-factor antagonist KS08_02330 ENOG4105FUA antagonist KS08_02335 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase KS08_02340 ENOG4107SGM protein serine threonine phosphatase KS08_02345 ENOG4105WN5 stage II sporulation protein KS08_02350 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KS08_02360 ENOG41064BQ Phosphatase KS08_02375 ENOG410906U SprT-like KS08_02425 ENOG4105K56 Transcriptional regulator KS08_02435 ENOG410645S MarR family Transcriptional regulator KS08_02440 ENOG4105DCM major facilitator superfamily KS08_02445 ENOG4105D3P Mannan endo-1,4-beta-mannosidase KS08_02465 ENOG410847I Transcriptional regulator, BadM Rrf2 family KS08_02475 ENOG4105VEQ Cold shock protein KS08_02495 ENOG4107U9B transcriptional regulator KS08_02500 ENOG4105DXI Major Facilitator superfamily KS08_02505 ENOG4105IRW patatin-like phospholipase family protein KS08_02515 ENOG4105DNP FAD linked oxidase domain protein KS08_02525 ENOG4105PGM cation diffusion facilitator family transporter KS08_02535 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein KS08_02540 ENOG4108U7W acetyltransferase KS08_02545 ENOG41086D8 Transcriptional regulator KS08_02570 ENOG4105DQ4 alcohol dehydrogenase KS08_02575 ENOG4105VUF Transcriptional regulator KS08_02585 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KS08_02595 ENOG4105EQ0 Major Facilitator superfamily KS08_02600 ENOG4108JGH Tetr family transcriptional regulator KS08_02605 ENOG4105T38 integral membrane protein KS08_02610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KS08_02625 ENOG4105E2A Dehydrogenase KS08_02630 ENOG4105PGS Spore coat protein KS08_02640 ENOG4105EYF MMPL domain protein KS08_02660 ENOG4108JYZ YitT family KS08_02670 ENOG4105C2C drug resistance transporter, Bcr CflA KS08_02675 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KS08_02695 ENOG41090E6 transcriptional regulator MERR family KS08_02710 ENOG4105EBM Alpha Beta Hydrolase Fold protein KS08_02715 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KS08_02720 ENOG4105DRR Transcriptional regulator, GntR family KS08_02735 ENOG4105FQP Beta-lactamase KS08_02740 ENOG41090UD (LipO)protein KS08_02745 ENOG4108SUT Major Facilitator Superfamily KS08_02750 ENOG4108TZY GntR Family Transcriptional Regulator KS08_02755 ENOG4105JXH GntR family transcriptional regulator KS08_02760 ENOG4105DJ2 Major Facilitator Superfamily KS08_02780 ENOG4107QTZ amino acid KS08_02800 ENOG4107QNK )-transporter KS08_02840 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) KS08_02845 ENOG4105K8N protein family UPF0079, ATPase KS08_02850 ENOG41072GX Peptidase M22 Glycoprotease KS08_02855 ENOG410801F ribosomal-protein-alanine acetyltransferase KS08_02860 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KS08_02865 ENOG4105C5H ABC transporter KS08_02870 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KS08_02875 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) KS08_02880 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KS08_02885 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KS08_02895 ENOG4108TYN CAAX amino terminal protease family protein KS08_02900 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) KS08_02905 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) KS08_02910 ENOG4105ESF Peptidoglycan binding domain protein KS08_02925 ENOG4105PGZ NB-ARC domain KS08_02930 ENOG4105CPQ Dehydrogenase KS08_02935 ENOG4105CT4 transporter KS08_02950 ENOG41087YS Phage shock protein A KS08_02955 ENOG4105DQX Zinc finger domain KS08_02960 ENOG4108WV1 Pfam:DUF477 KS08_02970 ENOG4105EXC Acyl-transferase KS08_02975 ENOG4108P49 AntiSigma factor KS08_02980 ENOG4105JVQ RNA Polymerase KS08_03010 ENOG4107STQ Multicopper oxidase KS08_03015 ENOG4105C85 amino acid KS08_03030 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KS08_03045 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KS08_03060 ENOG4105C7N Xanthine uracil vitamin C permease KS08_03085 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) KS08_03090 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit KS08_03095 ENOG4105C83 adenylosuccinate lyase KS08_03100 ENOG4105C8V SAICAR synthetase KS08_03105 ENOG4105VR9 phosphoribosylformylglycinamidine synthase KS08_03110 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I KS08_03115 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii KS08_03125 ENOG4105CXB phosphoribosylaminoimidazole synthetase KS08_03130 ENOG4108V3E phosphoribosylglycinamide formyltransferase KS08_03135 ENOG4105DC1 bifunctional purine biosynthesis protein purh KS08_03140 ENOG4105C12 Phosphoribosylglycinamide synthetase KS08_03150 ENOG4105DVH amino acid KS08_03165 ENOG4108R5T secreted protein KS08_03170 ENOG4105KGF protein, YerC YecD KS08_03175 ENOG4105CBC glutamate synthase KS08_03190 ENOG4105C4R Atp-dependent dna helicase KS08_03195 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) KS08_03205 ENOG4105CRN Aminoglycoside phosphotransferase KS08_03210 ENOG4105KT7 mgtC SapB transporter KS08_03215 ENOG4105CK7 Sodium proline symporter KS08_03220 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KS08_03225 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KS08_03230 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KS08_03235 ENOG4108IG5 Transcriptional regulator KS08_03245 ENOG4105CBD Diacylglycerol kinase KS08_03250 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KS08_03260 ENOG4105CJ1 ABC, transporter KS08_03290 ENOG4105CDY transcriptional regulatory protein KS08_03300 ENOG41075D4 Aminoglycoside 6-adenylyltransferase KS08_03315 ENOG4105WEF catalase KS08_03320 ENOG4105M18 -acetyltransferase KS08_03330 ENOG4105H67 Protein of unknown function (DUF421) KS08_03335 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) KS08_03340 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KS08_03360 ENOG4106I4J membrane KS08_03365 ENOG41082F9 transcriptional regulator KS08_03370 ENOG41061H0 Monooxygenase KS08_03375 ENOG4108R1P KS08_03380 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KS08_03390 ENOG4105E0M Sulfatase KS08_03395 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase KS08_03405 ENOG41090R9 glycosyltransferase KS08_03410 ENOG4107R51 Glycosyl transferase, family 2 KS08_03415 ENOG41090R9 glycosyltransferase KS08_03420 ENOG4105EU0 Major facilitator Superfamily KS08_03425 ENOG4105CUB amino acid KS08_03430 ENOG4105C26 Dehydrogenase KS08_03435 ENOG4105FKZ Methyl-accepting chemotaxis KS08_03440 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KS08_03445 ENOG4107TVC Glycosyl transferase, family 2 KS08_03450 ENOG4105C5H ABC transporter KS08_03455 ENOG4107SWG transcriptional regulator MERR family KS08_03460 ENOG4105DXB Major Facilitator superfamily KS08_03465 ENOG4105C5H ABC transporter KS08_03470 ENOG4105FDU atp-dependent rna helicase KS08_03475 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein KS08_03490 ENOG4108J20 pectate lyase KS08_03495 ENOG4107QPK )-transporter KS08_03520 ENOG4108NEV two component transcriptional regulator, LytTR family KS08_03530 ENOG4108Z6X (sortase) family KS08_03540 ENOG4108MRH transcriptional regulatory protein KS08_03565 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) KS08_03570 ENOG4108RPX mosc domain containing protein KS08_03590 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) KS08_03630 ENOG4105C5Y PTS System KS08_03635 ENOG4105CG3 alpha amylase, catalytic region KS08_03640 ENOG4107414 GntR family transcriptional regulator KS08_03645 ENOG4108RCM Nitroreductase KS08_03660 ENOG4105CGH 5'-nucleotidase KS08_03665 ENOG4107RKG DJ-1/PfpI family KS08_03670 ENOG4105ETE Transcriptional regulator (LacI family KS08_03675 ENOG4105E2X shikimate dehydrogenase KS08_03680 ENOG4105FF2 Type I DHQase KS08_03695 ENOG4105KJF protein tyrosine phosphatase KS08_03705 ENOG4107U9T Pfam:Ribonuclease_BN KS08_03715 ENOG4108ISG Major Facilitator KS08_03720 ENOG4105UPD Calcium Proton KS08_03730 ENOG4105D8X mechanosensitive ion channel KS08_03750 ENOG4106KE4 Dehydrogenase KS08_03760 ENOG4105D7N magnesium and cobalt transport protein CorA KS08_03770 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KS08_03785 ENOG4105BZ1 (ABC) transporter KS08_03790 ENOG4105CJA serine threonine protein kinase KS08_03810 ENOG4107RUY (E1 component), alpha subunit KS08_03820 ENOG4107QKR Dehydrogenase KS08_03830 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family KS08_03840 ENOG4105F8D glycoside hydrolase family 4 KS08_03845 ENOG4108Q3X Transcriptional regulator KS08_03850 ENOG4105CI1 PTS System KS08_03860 ENOG4105BZ1 (ABC) transporter KS08_03865 ENOG4105BZ1 (ABC) transporter KS08_03875 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KS08_03885 ENOG4105U3E Transcriptional regulator KS08_03890 ENOG4105DYS nad(p)h dehydrogenase (quinone) KS08_03895 ENOG4105H93 Acyltransferase family KS08_03905 ENOG4108YYS metal-dependent hydrolase (By similarity) KS08_03910 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS08_03915 ENOG410834F Transcriptional regulator KS08_03925 ENOG4105JAB phenazine biosynthesis protein, phzf family KS08_03930 ENOG4107Y03 Nitroreductase KS08_03945 ENOG4105ECP epimerase KS08_03950 ENOG410902V Modulates RecA activity (By similarity) KS08_03960 ENOG4105F27 Major Facilitator KS08_03970 ENOG4108TCS Glutamyl endopeptidase KS08_03990 ENOG4106AKJ KS08_03995 ENOG4105D74 hydrolase KS08_04000 ENOG4105CKK Glycosyl transferase, family 2 KS08_04005 ENOG4105EJV Membrane KS08_04010 ENOG41067AE Membrane-bound metal-dependent hydrolase KS08_04015 ENOG4105CEN a g-specific adenine glycosylase KS08_04020 ENOG4106BXE KS08_04025 ENOG4105CAN Short-chain dehydrogenase reductase Sdr KS08_04045 ENOG4105BZ1 (ABC) transporter KS08_04050 ENOG4107NBY Membrane KS08_04055 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KS08_04060 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KS08_04065 ENOG4105G5W regulator Fur family KS08_04070 ENOG4105TUA UPF0295 protein KS08_04175 ENOG4107S6Z Na H antiporter KS08_04180 ENOG4105EC3 peptidase S51, dipeptidase E KS08_04185 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) KS08_04190 ENOG4105DNP FAD linked oxidase domain protein KS08_04200 ENOG4105DEF Extracellular solute-binding protein, family 5 KS08_04210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS08_04215 ENOG4105C3U ABC transporter KS08_04235 ENOG4105E2Y ABC, transporter KS08_04240 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein KS08_04245 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component KS08_04265 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) KS08_04270 ENOG4107D63 KS08_04275 ENOG4105VZ8 Transcriptional regulator KS08_04290 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) KS08_04300 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) KS08_04320 ENOG4105CYN Serine protein kinase KS08_04330 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes KS08_04335 ENOG4105CW7 secretion protein, HlyD family KS08_04340 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS08_04345 ENOG4105CS1 NAD(P)H quinone oxidoreductase KS08_04360 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family KS08_04365 ENOG4105CZV ABC transporter KS08_04370 ENOG4105CJ1 ABC, transporter KS08_04375 ENOG4108TU7 Inherit from COG: (ABC) transporter KS08_04380 ENOG4105VEQ Cold shock protein KS08_04390 ENOG4105BZU Histidine kinase KS08_04400 ENOG4105CE7 Amidase, hydantoinase carbamoylase family KS08_04435 ENOG4108YBP pseudouridine synthase KS08_04445 ENOG41080XP Cbs domain KS08_04450 ENOG4107YBY Hydrolase KS08_04455 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KS08_04460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KS08_04465 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator KS08_04475 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) KS08_04480 ENOG4105C6V Glycerol-3-phosphate dehydrogenase KS08_04490 ENOG4105BZU Histidine kinase KS08_04495 ENOG4105WH1 Two component transcriptional regulator luxr family KS08_04530 ENOG4105ED1 spovr family KS08_04535 ENOG4105G6Z alkaline phosphatase KS08_04550 ENOG4105BZN citrate synthase KS08_04555 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KS08_04560 ENOG4105CUB amino acid KS08_04565 ENOG4105C8J )-transporter KS08_04575 ENOG4105J37 KS08_04580 ENOG4108AEY RNA polymerase sigma factor KS08_04585 ENOG4105F6E Acyl-transferase KS08_04590 ENOG4105C37 (CBS) domain KS08_04600 ENOG4105CHM Aminotransferase KS08_04605 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase KS08_04610 ENOG4105C37 (CBS) domain KS08_04620 ENOG4105WMR Protein CrcB homolog KS08_04625 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KS08_04635 ENOG4105D64 Mechanosensitive ion channel KS08_04640 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) KS08_04645 ENOG4107VMI polysaccharide deacetylase KS08_04650 ENOG4105F0I Aminotransferase KS08_04655 ENOG4105W1N transcriptional regulator KS08_04660 ENOG4105IIP Membrane KS08_04670 ENOG4105BZ1 (ABC) transporter KS08_04675 ENOG4105BZ1 (ABC) transporter KS08_04700 ENOG410839P KS08_04710 ENOG4106MP8 UPF0754 membrane protein KS08_04715 ENOG4105WZB UPF0342 protein KS08_04725 ENOG4105D4P Coproporphyrinogen iii oxidase KS08_04735 ENOG4107S91 Sodium hydrogen exchanger KS08_04740 ENOG4105NCW Trka-c domain protein KS08_04750 ENOG4105CGU Enoyl-CoA hydratase KS08_04760 ENOG4108IUX (ABC) transporter KS08_04765 ENOG4105RHA ABC transporter, permease KS08_04770 ENOG4107VRP DNA repair exonuclease KS08_04775 ENOG4106D4I domain protein KS08_04780 ENOG4105EQI Metal Dependent Phosphohydrolase KS08_04790 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KS08_04835 ENOG4105NBU tryptophan transport protein KS08_04840 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) KS08_04845 ENOG4105K59 histidine triad (HIT) protein KS08_04875 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation KS08_04880 ENOG4105BZ4 penicillin-binding protein KS08_04885 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) KS08_04890 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) KS08_04895 ENOG4105C1Q protoporphyrinogen oxidase KS08_04905 ENOG4105ECB domain protein KS08_04920 ENOG4105DER m42 family KS08_04930 ENOG4106AXD KS08_04935 ENOG4108RQ5 Beta-lactamase domain-containing protein KS08_04940 ENOG4105DF9 Lipoate-protein, ligase KS08_04950 ENOG4105CEY Amp-dependent synthetase and ligase KS08_04960 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 KS08_04970 ENOG4108HUF Transporter KS08_04975 ENOG4107TB6 phosphoglycerate mutase KS08_04985 ENOG4107F3J Amp-dependent synthetase and ligase KS08_04990 ENOG4107ZYJ bioY protein KS08_04995 ENOG4106YBV Methyl-accepting chemotaxis KS08_05015 ENOG4105XVF Competence transcription factor KS08_05020 ENOG4108ZMX Domain of unknown function (DU1801) KS08_05035 ENOG4105X3H Excalibur domain protein KS08_05040 ENOG4105K8R UPF0145 protein KS08_05045 ENOG4105E1V na solute symporter KS08_05050 ENOG4106CAD Protein of unknown function (DUF3311) KS08_05055 ENOG41060YP KS08_05070 ENOG4107SCK Monooxygenase KS08_05075 ENOG4108INS Transcriptional regulator KS08_05080 ENOG4108KK1 membrane protein AbrB duplication KS08_05090 ENOG4108IG5 Transcriptional regulator KS08_05100 ENOG4108QY0 Membrane KS08_05105 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination KS08_05110 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation KS08_05120 ENOG4105EYH Exonuclease KS08_05165 ENOG4105ERH Fumarylacetoacetate hydrolase KS08_05175 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KS08_05185 ENOG4105CAQ asparagine synthetase KS08_05195 ENOG4105UQX Mate efflux family protein KS08_05200 ENOG4106HBX Transcriptional Regulator AraC Family KS08_05205 ENOG4105ETE Transcriptional regulator (LacI family KS08_05210 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KS08_05215 ENOG4105SF0 DinB family KS08_05220 ENOG4108ZUB Lysine exporter protein (Lyse ygga) KS08_05225 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KS08_05230 ENOG4105MYW Pentapeptide repeat protein KS08_05235 ENOG4105MA6 gCN5-related N-acetyltransferase KS08_05245 ENOG4108VPT UPF0234 protein KS08_05250 ENOG4105QNR S1 RNA binding domain protein KS08_05255 ENOG4105DIH basic membrane KS08_05260 ENOG4105C8Q Methyl-accepting chemotaxis KS08_05265 ENOG4107E6A Cytochrome p-450 KS08_05270 ENOG4105EPR degv family KS08_05275 ENOG4107AYK membrAne KS08_05285 ENOG41073B9 KS08_05295 ENOG4108KP7 hydrolase KS08_05300 ENOG4108MXZ Esterase KS08_05305 ENOG4105VG1 fes assembly suf system protein KS08_05310 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) KS08_05315 ENOG4105IQ5 FAD linked oxidase domain protein KS08_05325 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase KS08_05335 ENOG4105CAS nag kinase KS08_05340 ENOG4105C8Y Acetylornithine aminotransferase KS08_05345 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KS08_05355 ENOG4105DBV ornithine carbamoyltransferase KS08_05380 ENOG4107RMD Basic membrane lipoprotein KS08_05395 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KS08_05400 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KS08_05410 ENOG4105C3U ABC transporter KS08_05415 ENOG4108JQ7 (ABC) transporter KS08_05430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS08_05440 ENOG4105C31 Tryptophanyl-tRNA synthetase KS08_05445 ENOG4108J59 Extracellular solute-binding protein, family 5 KS08_05450 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KS08_05455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS08_05465 ENOG4108JQ7 (ABC) transporter KS08_05480 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) KS08_05485 ENOG4108ZCF integral membrane protein KS08_05490 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis KS08_05500 ENOG4105DPN Oligoendopeptidase f KS08_05515 ENOG4105T58 Dithiol-disulfide isomerase KS08_05520 ENOG4108Z18 K06886 hemoglobin KS08_05525 ENOG4105E4C Lytic transglycosylase catalytic KS08_05530 ENOG4105MIX Adenylate cyclase KS08_05545 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KS08_05550 ENOG4105EMS pseudouridine synthase KS08_05555 ENOG4107S1Q Phosphatase KS08_05565 ENOG4105ETU transcriptional activator (TenA KS08_05570 ENOG4108VEU Thiamine monophosphate synthase KS08_05590 ENOG4105D06 uba thif-type nad fad binding protein KS08_05595 ENOG4105DWF phosphomethylpyrimidine kinase KS08_05600 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH KS08_05605 ENOG4107A88 KS08_05660 ENOG4105ENA helicase KS08_05680 ENOG4105CJ1 ABC, transporter KS08_05695 ENOG4108ZMI UPF0477 protein KS08_05705 ENOG4105C28 cystathionine KS08_05710 ENOG4105C28 cystathionine KS08_05720 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) KS08_05725 ENOG410635T phage-like element pbsx protein KS08_05735 ENOG4107Y9E nuclease KS08_05740 ENOG41067QW Transcriptional regulator KS08_05805 ENOG4105QBX endodeoxyribonuclease RusA KS08_05880 ENOG4107KNS KS08_05970 ENOG4108FKH Transglycosylase SLT domain KS08_06010 ENOG41068G1 KS08_06060 ENOG4106BHF KS08_06120 ENOG4105DB4 KS08_06125 ENOG4105DB4 KS08_06135 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KS08_06190 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS08_06205 ENOG4105CK1 PTS System KS08_06210 ENOG4105VCP PTS System KS08_06215 ENOG4105CS2 ec 3.2.1.21 KS08_06220 ENOG4105E98 transcriptional regulator DeoR family KS08_06240 ENOG4105KT7 mgtC SapB transporter KS08_06260 ENOG4108IEG Formate dehydrogenase Alpha subunit KS08_06270 ENOG4106A3M Cytochrome p-450 KS08_06275 ENOG41087PP glycosyltransferase MGT family KS08_06285 ENOG4105EXQ uroporphyrinogen iii synthase hem4 KS08_06290 ENOG4105C4B ABC transporter, permease KS08_06295 ENOG4108IXI (ABC) transporter KS08_06305 ENOG4105Q95 Cupin 2, conserved barrel domain protein KS08_06320 ENOG4105D2H Uronic isomerase KS08_06325 ENOG4107KJX Transcriptional regulator KS08_06330 ENOG4105CTX dehydratase KS08_06335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS08_06340 ENOG4105F3H Histidine kinase KS08_06350 ENOG4107TSN permease KS08_06370 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KS08_06375 ENOG4105KWG Pfam:DUF1696 KS08_06380 ENOG4105K7W phage-related replication protein KS08_06385 ENOG410635T phage-like element pbsx protein KS08_06430 ENOG4108TFU terminase (Small subunit) KS08_06435 ENOG4105IG6 Phage terminase, large subunit KS08_06440 ENOG4108MDF Phage Portal Protein KS08_06465 ENOG41060SN KS08_06480 ENOG4105PQS phage protein KS08_06485 ENOG4105FR7 XkdM protein, phage-like element PBSX KS08_06490 ENOG4105MTC XkdN-like protein KS08_06500 ENOG4108FKH Transglycosylase SLT domain KS08_06500 ENOG4108FKH Transglycosylase SLT domain KS08_06500 ENOG4108FKH Transglycosylase SLT domain KS08_06505 ENOG4108WZM domain protein KS08_06510 ENOG4105X7F KS08_06520 ENOG4105MFU Protein of unknown function (DUF2634) KS08_06525 ENOG41066EA baseplate J family protein KS08_06530 ENOG410906S phage-like element pbsx protein xkdt KS08_06540 ENOG41068G1 KS08_06570 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KS08_06585 ENOG4105CJ3 phosphate transporter KS08_06590 ENOG4107GRR phosphate transport regulator KS08_06595 ENOG4107R7I amino acid KS08_06605 ENOG4105EDW glycosyl transferase, family 39 KS08_06610 ENOG4105CKK Glycosyl transferase, family 2 KS08_06615 ENOG4105C0H protease KS08_06625 ENOG4108ME1 Peptidase M55 D-aminopeptidase KS08_06630 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KS08_06635 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS08_06640 ENOG4105C3U ABC transporter KS08_06650 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A KS08_06655 ENOG4105DTQ mandelate racemase muconate lactonizing KS08_06660 ENOG4107SN7 NLP P60 protein KS08_06665 ENOG4108JQ7 (ABC) transporter KS08_06670 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) KS08_06675 ENOG4107TUM Amidinotransferase KS08_06680 ENOG4108S4H thioesterase Superfamily protein KS08_06685 ENOG4108428 Inherit from COG: -acetyltransferase KS08_06695 ENOG41080TC multidrug resistance protein KS08_06705 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KS08_06720 ENOG4105K56 Transcriptional regulator KS08_06725 ENOG4108ZHJ Organic hydroperoxide resistance protein KS08_06740 ENOG4107TVC Glycosyl transferase, family 2 KS08_06755 ENOG4108Y4K DNA-binding transcriptional activator KS08_06760 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) KS08_06765 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KS08_06775 ENOG4108W7F transporter, permease KS08_06780 ENOG4108JJB ABC transporter KS08_06785 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein KS08_06790 ENOG4105VRS hydrolase family 18 KS08_06805 ENOG4105CJW magnesium transporter KS08_06810 ENOG4105V75 Transcriptional regulator KS08_06835 ENOG4105DQE DNA ligase KS08_06840 ENOG4105FDF Could be involved in DNA repair (By similarity) KS08_06845 ENOG4105BZU Histidine kinase KS08_06850 ENOG4107T5V SNARE associated Golgi KS08_06855 ENOG4107TS3 membrane protein, TerC KS08_06860 ENOG4108WZW RNA polymerase sigma KS08_06870 ENOG410681C small acid-soluble spore protein KS08_06880 ENOG4105D0M Protease HtpX homolog KS08_06905 ENOG4108TGC Acyltransferase KS08_06910 ENOG4105BZU Histidine kinase KS08_06915 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KS08_06920 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) KS08_06930 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KS08_06940 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate KS08_06945 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) KS08_06950 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) KS08_06955 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) KS08_06965 ENOG4105BZU Histidine kinase KS08_06970 ENOG41090MY MarR family Transcriptional regulator KS08_06975 ENOG4105ER2 Ompa motb domain protein KS08_06980 ENOG4105E14 MotA TolQ exbB proton channel KS08_06990 ENOG4108K88 Membrane KS08_07000 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) KS08_07005 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase KS08_07010 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) KS08_07015 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) KS08_07035 ENOG4105F0V Cell wall hydrolase KS08_07050 ENOG4105C59 p-type ATPase KS08_07055 ENOG4105DC7 peptidase M24 KS08_07070 ENOG4105CID antiterminator KS08_07080 ENOG4105KRI phosphocarrier protein (HPr KS08_07085 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KS08_07095 ENOG4105F6S Spore photoproduct lyase KS08_07100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer KS08_07105 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KS08_07115 ENOG4105K4I Scp-like extracellular KS08_07125 ENOG4105BZU Histidine kinase KS08_07130 ENOG4105CHM Aminotransferase KS08_07140 ENOG4107R88 Chemotaxis protein (CheV) KS08_07145 ENOG4105UIN KS08_07155 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein KS08_07165 ENOG4105K6S Short-chain dehydrogenase reductase Sdr KS08_07175 ENOG4105EPM Diguanylate phosphodiesterase KS08_07180 ENOG4107IN1 Protein of unknown function (DUF1797) KS08_07185 ENOG4108XRC Protein of unknown function (DUF458) KS08_07215 ENOG4105NQC Flavodoxin KS08_07235 ENOG4105D8X mechanosensitive ion channel KS08_07245 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KS08_07260 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) KS08_07265 ENOG4105D06 uba thif-type nad fad binding protein KS08_07270 ENOG4105CVM Molybdenum cofactor synthesis domain protein KS08_07275 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein KS08_07280 ENOG4108ZAF Molybdopterin KS08_07285 ENOG41067WU Molybdopterin converting factor (Subunit 1) KS08_07295 ENOG4107X8C Efflux transporter RND family MFP subunit KS08_07300 ENOG4105C19 ABC transporter KS08_07305 ENOG4107RBB ABC transporter, permease KS08_07310 ENOG4105E98 transcriptional regulator DeoR family KS08_07315 ENOG4105DE4 1-phosphofructokinase KS08_07320 ENOG4105DM4 PTS System KS08_07335 ENOG4105C5H ABC transporter KS08_07340 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) KS08_07365 ENOG4105BZU Histidine kinase KS08_07375 ENOG4107ZYR domain protein KS08_07380 ENOG4105CPN adenine deaminase KS08_07385 ENOG4105CN5 Metallo-Beta-Lactamase KS08_07390 ENOG4106148 UPF0356 protein KS08_07395 ENOG4108X4Q Hydrolase KS08_07400 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KS08_07420 ENOG4105CPP Dehydrogenase, E1 component KS08_07425 ENOG4105C7S Dehydrogenase KS08_07430 ENOG4107QN2 dihydrolipoyl dehydrogenase KS08_07445 ENOG4105CXN decarboxylase KS08_07450 ENOG4105WBI UPF0223 protein KS08_07465 ENOG4105ECY inositol monophosphatase KS08_07475 ENOG4105D4Y metalloprotease KS08_07500 ENOG4105CI3 gtp-binding protein typa KS08_07505 ENOG4105QA2 KS08_07520 ENOG4108IAB Phoh family KS08_07530 ENOG4105CSV Glutaminase KS08_07540 ENOG4105CNI cell division protein FtsW KS08_07545 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) KS08_07555 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KS08_07565 ENOG4105BZ9 Cytochrome C oxidase, subunit I KS08_07570 ENOG4105CCU oxidase (Subunit III) KS08_07575 ENOG41064X9 cytochrome C oxidase subunit IV KS08_07590 ENOG41080XQ Signal transduction protein with cbs domains KS08_07595 ENOG4106UY4 Inherit from COG: Scp-like extracellular KS08_07620 ENOG4106H78 methyltransferase KS08_07625 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) KS08_07630 ENOG4105H20 Sporulation integral membrane protein YlbJ KS08_07635 ENOG4105D78 K07001 NTE family protein KS08_07640 ENOG41063PX domain protein KS08_07645 ENOG4105CDE UPF0348 protein KS08_07650 ENOG4105KNH Nucleic acid-binding protein KS08_07655 ENOG41067VY 50S ribosomal protein L32 KS08_07680 ENOG4108V6E Cell division protein mraZ KS08_07685 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) KS08_07695 ENOG4105CJN penicillin-binding protein KS08_07700 ENOG4105CJN penicillin-binding protein KS08_07705 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KS08_07715 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) KS08_07720 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) KS08_07725 ENOG4105CNI cell division protein FtsW KS08_07730 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KS08_07735 ENOG4105D4A Cell wall formation (By similarity) KS08_07740 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) KS08_07750 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) KS08_07755 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) KS08_07765 ENOG4105FFI sigma-e processing peptidase spoiiga KS08_07770 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS08_07780 ENOG4105DKW ABC transporter KS08_07790 ENOG4105WR5 sporulation protein, YlmC YmxH family KS08_07795 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase KS08_07800 ENOG4105DFA alanine racemase domain protein KS08_07805 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) KS08_07810 ENOG41067XK integral membrane protein KS08_07815 ENOG4105DBK s4 domain protein KS08_07830 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KS08_07840 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) KS08_07845 ENOG4105C34 Pseudouridine synthase KS08_07850 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) KS08_07860 ENOG4105CXT aspartate transcarbamylase KS08_07870 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KS08_07875 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain KS08_07880 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) KS08_07885 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) KS08_07890 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) KS08_07895 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) KS08_07915 ENOG4107RIQ Sulfate adenylate transferase KS08_07925 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KS08_07930 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein KS08_07935 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein KS08_07945 ENOG4105F23 Fibronectin-binding protein KS08_07955 ENOG4105DSJ YicC domain protein KS08_07960 ENOG4105KC4 UPF0296 protein KS08_07965 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) KS08_07975 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase KS08_07980 ENOG4105C25 Primosomal protein n' KS08_07985 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KS08_07990 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) KS08_07995 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B KS08_08000 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KS08_08005 ENOG4108ZF3 Phosphatase KS08_08010 ENOG4105D9P serine threonine protein kinase KS08_08015 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) KS08_08020 ENOG4105DJV ribulose-phosphate 3-epimerase KS08_08025 ENOG4105FJ0 thiamine KS08_08035 ENOG4105VB9 50S ribosomal protein l28 KS08_08040 ENOG4108ZAA Alkaline-shock protein KS08_08045 ENOG4105DP4 dak2 domain fusion protein ylov KS08_08055 ENOG4105EJQ L-serine dehydratase KS08_08060 ENOG4105CB5 ATP-dependent DNA helicase recG KS08_08065 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) KS08_08070 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) KS08_08075 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KS08_08080 ENOG4105CHR reductase KS08_08085 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) KS08_08090 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) KS08_08095 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) KS08_08100 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KS08_08105 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) KS08_08115 ENOG4105K5M 30s ribosomal protein S16 KS08_08120 ENOG4108BW8 UPF0109 protein KS08_08135 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) KS08_08140 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) KS08_08145 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) KS08_08150 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KS08_08160 ENOG4105VM1 flagellar KS08_08165 ENOG4105CMV Succinyl-CoA synthetase subunit beta KS08_08170 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha KS08_08175 ENOG4105C79 DNA protecting protein DprA KS08_08180 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) KS08_08185 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) KS08_08190 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KS08_08195 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) KS08_08200 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) KS08_08215 ENOG4108ZC9 flagellar basal-body rod protein flgc KS08_08220 ENOG4105VQ0 flagellar hook-basal body complex protein fliE KS08_08225 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) KS08_08230 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KS08_08245 ENOG4106YF4 Flagellar biosynthesis chaperone KS08_08255 ENOG410696Y Flagellar hook-length control protein KS08_08260 ENOG410822I Flagellar hook capping protein KS08_08265 ENOG4108JQA flagellar KS08_08270 ENOG41068WV flagellar FlbD family protein KS08_08280 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KS08_08285 ENOG4105DD5 Flagellar motor switch protein KS08_08290 ENOG4107YTP response regulator receiver protein KS08_08300 ENOG4105CN7 Flagellar biosynthetic protein FliP KS08_08305 ENOG4105VS8 Flagellar biosynthetic protein fliq KS08_08310 ENOG4105D19 Role in flagellar biosynthesis (By similarity) KS08_08315 ENOG4105D00 flagellar biosynthetic protein flhB KS08_08320 ENOG4105D7B Flagellar biosynthesis protein flha KS08_08325 ENOG4105FZW flagellar biosynthesis regulator FlhF KS08_08335 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) KS08_08340 ENOG4105CBS Chea signal transduction histidine kinase KS08_08345 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis KS08_08355 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) KS08_08360 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS08_08370 ENOG4105CE9 30S ribosomal protein S2 KS08_08380 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) KS08_08385 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) KS08_08390 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) KS08_08395 ENOG4105KNE Phosphatidate cytidylyltransferase KS08_08405 ENOG4105DZP Membrane-associated zinc metalloprotease KS08_08410 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) KS08_08415 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) KS08_08420 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) KS08_08425 ENOG4105CHV Transcription elongation factor NusA KS08_08430 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination KS08_08435 ENOG4105VHM ribosomal protein KS08_08440 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) KS08_08445 ENOG4105W7A Protein of unknown function (DUF503) KS08_08450 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) KS08_08455 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) KS08_08460 ENOG4105DTN riboflavin biosynthesis protein ribF KS08_08465 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) KS08_08470 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) KS08_08480 ENOG4105C1V Peptidase, M16 KS08_08490 ENOG4105E35 Dipicolinate synthase subunit A KS08_08495 ENOG4108S0H Dipicolinic acid synthetase, b subunit KS08_08500 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) KS08_08510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KS08_08520 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit KS08_08530 ENOG4105CNU cell division protein FtsK KS08_08535 ENOG4105FDP GntR family transcriptional regulator KS08_08550 ENOG4105EYF MMPL domain protein KS08_08565 ENOG4108RKS Short-chain dehydrogenase reductase Sdr KS08_08570 ENOG4105XZV Protein of unknown function (DUF3243) KS08_08585 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase KS08_08590 ENOG4105CEV competence damage-inducible protein KS08_08595 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) KS08_08600 ENOG4108A04 Beta-lactamase KS08_08610 ENOG4105D48 metallophosphoesterase KS08_08615 ENOG4105MCT stage V sporulation protein S KS08_08620 ENOG4105CPQ Dehydrogenase KS08_08625 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KS08_08630 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KS08_08650 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) KS08_08655 ENOG4108151 Beta-lactamase domain protein KS08_08660 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KS08_08665 ENOG4108JA1 polyketide synthase KS08_08670 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KS08_08675 ENOG41062T2 Acyl carrier protein KS08_08680 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KS08_08685 ENOG4108MGH Enoyl-CoA hydratase KS08_08690 ENOG4108KQ6 Enoyl-CoA hydratase KS08_08695 ENOG4105C0W non-ribosomal peptide synthetase KS08_08700 ENOG4107SQU synthase KS08_08710 ENOG4105C0W non-ribosomal peptide synthetase KS08_08720 ENOG4106A3M Cytochrome p-450 KS08_08725 ENOG4105WFK nuclease KS08_08730 ENOG4105XPP Protein of unknown function (DUF1275) KS08_08740 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KS08_08750 ENOG4105K7W phage-related replication protein KS08_08755 ENOG4108X3M OsmC Ohr family protein KS08_08780 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) KS08_08805 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KS08_08810 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KS08_08815 ENOG4105U6W MutT NUDIX family protein KS08_08830 ENOG4106F1P AAA ATPase, central domain protein KS08_08835 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) KS08_08840 ENOG4105CXI aluminum resistance protein KS08_08845 ENOG4105KV4 Transcriptional regulator KS08_08850 ENOG4105C5F glutamine synthetase KS08_08875 ENOG4107T94 Endo-14-beta-xylanase KS08_08885 ENOG4105CT4 transporter KS08_08890 ENOG4105DSG hydrolase family 43 KS08_08900 ENOG4105C93 Xylose Isomerase KS08_08905 ENOG4105CMG Carbohydrate kinase KS08_08915 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) KS08_08935 ENOG410780I phosphoprotein phosphatase activity KS08_08955 ENOG4105DQ4 alcohol dehydrogenase KS08_08980 ENOG4105EPI acetyltransferase, (GNAT) family KS08_09015 ENOG4108M1A Chitin-binding protein KS08_09035 ENOG4105YB8 TM2 domain containing protein KS08_09040 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KS08_09050 ENOG4105K7W phage-related replication protein KS08_09070 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) KS08_09080 ENOG4108SVB resolvase KS08_09085 ENOG4105VPS UPF0291 protein KS08_09090 ENOG4105CV1 Transketolase (EC 2.2.1.1) KS08_09100 ENOG4105VXM UPF0154 protein KS08_09110 ENOG4107QIV Cytochrome c biogenesis protein KS08_09145 ENOG4108I0Z Aconitate hydratase KS08_09150 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KS08_09165 ENOG41067CD Small, acid-soluble spore protein Tlp KS08_09175 ENOG4105MI2 KS08_09180 ENOG4105W8X HesB YadR YfhF-family protein KS08_09185 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) KS08_09190 ENOG4105K4P CoA-binding domain protein KS08_09195 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KS08_09230 ENOG4105FVX KS08_09250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS08_09260 ENOG4107SYN Glycosyl hydrolases family 43 KS08_09285 ENOG4105DTD Dehydrogenase KS08_09290 ENOG4108IIH CoA-transferase subunit B KS08_09295 ENOG4105D6N CoA-transferase, subunit a KS08_09300 ENOG4106A3M Cytochrome p-450 KS08_09305 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) KS08_09310 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) KS08_09315 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KS08_09320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KS08_09335 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KS08_09340 ENOG4107T5V SNARE associated Golgi KS08_09345 ENOG4107QX3 carboxylase KS08_09350 ENOG4105E39 Enoyl-CoA hydratase KS08_09355 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase KS08_09360 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit KS08_09365 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KS08_09370 ENOG4105CEY Amp-dependent synthetase and ligase KS08_09375 ENOG4105C1G acyl-Coa dehydrogenase KS08_09380 ENOG4105F32 YngK protein KS08_09385 ENOG4106U2H Protein of unknown function (DUF1360) KS08_09395 ENOG4105CEY Amp-dependent synthetase and ligase KS08_09400 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family KS08_09405 ENOG4108N2V aldose 1-epimerase KS08_09410 ENOG4107QJQ Mate efflux family protein KS08_09435 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KS08_09440 ENOG4108RWP Major Facilitator Superfamily protein KS08_09445 ENOG4105WAB arsR family transcriptional regulator KS08_09450 ENOG4105C22 threonyL-tRNA synthetase KS08_09455 ENOG4108KSA LysR family transcriptional regulator KS08_09460 ENOG4105CB2 alcohol dehydrogenase KS08_09470 ENOG4105BZ8 glutamate synthase KS08_09475 ENOG4105CBC glutamate synthase KS08_09480 ENOG4105C5Q Transcriptional regulator KS08_09485 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KS08_09510 ENOG4108UB7 KS08_09515 ENOG4105IE8 Alpha-ketoglutarate permease KS08_09520 ENOG4107U6E carbohydrate kinase FGGY KS08_09525 ENOG4108M3J Dehydrogenase KS08_09530 ENOG4108J2R molybdopterin oxidoreductase KS08_09560 ENOG4108Z7R Chaperone CsaA KS08_09565 ENOG4105FTV AraC Family Transcriptional Regulator KS08_09575 ENOG4108W8B Beta-lactamase domain protein KS08_09585 ENOG4105KTU Transcriptional regulator, arsr family KS08_09595 ENOG4108SJC Membrane KS08_09620 ENOG41069ER domain protein KS08_09625 ENOG4105C9U ATP-dependent DNA helicase RecQ KS08_09635 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KS08_09640 ENOG4105SCY DNAK suppressor KS08_09685 ENOG4105C26 Dehydrogenase KS08_09690 ENOG4105EWU Squalene--hopene cyclase KS08_09695 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KS08_09700 ENOG4105C8J )-transporter KS08_09705 ENOG4105C09 Bile acid KS08_09715 ENOG4105C7S Dehydrogenase KS08_09720 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 KS08_09725 ENOG4107T89 von Willebrand factor, type A KS08_09730 ENOG4105GMT ATPase associated with various cellular activities aaa_5 KS08_09740 ENOG4105K4H Nlp p60 protein KS08_09745 ENOG41087PP glycosyltransferase MGT family KS08_09755 ENOG4107QMU Mate efflux family protein KS08_09760 ENOG4106SCS STAS domain KS08_09780 ENOG4105FR1 rard protein KS08_09795 ENOG41090U3 tautomerase KS08_09815 ENOG4105FBA Phospholipase Carboxylesterase KS08_09830 ENOG4105E1V na solute symporter KS08_09840 ENOG4105CS2 ec 3.2.1.21 KS08_09845 ENOG4108S3Y transcriptional regulator KS08_09865 ENOG4108VXD carboxy-peptidase KS08_09870 ENOG4105D3A purine nucleoside phosphorylase DeoD-type KS08_09880 ENOG4106Z5R KS08_09885 ENOG410841Q phosphoesterase PA-phosphatase related protein KS08_09905 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KS08_09920 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein KS08_09925 ENOG4108TSC N-acetyltransferase KS08_09930 ENOG4107S4Y M20 DapE family protein YgeY KS08_09945 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KS08_09955 ENOG4105FTQ Dna gyrase KS08_10010 ENOG4105DMF Dehydrogenase KS08_10030 ENOG4105C5E polysaccharide biosynthesis protein KS08_10035 ENOG4105E0X reductase KS08_10040 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KS08_10050 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) KS08_10055 ENOG41090WU lipolytic protein G-D-S-L family KS08_10060 ENOG4108KF3 Electron transport protein SCO1 SenC KS08_10070 ENOG4105C7B Threonine dehydratase KS08_10080 ENOG4108UT2 hemolysin iii KS08_10090 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KS08_10095 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) KS08_10105 ENOG4107YX5 Pfam:DUF548 KS08_10110 ENOG4108Y6J UPF0403 protein KS08_10115 ENOG4105C01 Dihydroxy-acid dehydratase KS08_10130 ENOG4108V06 Glutathione peroxidase KS08_10135 ENOG4105CVG Homoserine O-transsuccinylase KS08_10175 ENOG41081VK Ribonuclease KS08_10200 ENOG410890F Dynamin family KS08_10210 ENOG41065KQ synthase KS08_10235 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) KS08_10270 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KS08_10275 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) KS08_10300 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KS08_10350 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KS08_10360 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) KS08_10440 ENOG4105DVF Cytosine-specific methyltransferase KS08_10450 ENOG4106210 phosphatase activity KS08_10525 ENOG4108R1E Serine threonine protein phosphatase 1 KS08_10535 ENOG4105K7W phage-related replication protein KS08_10570 ENOG4108RAV Conserved protein KS08_10575 ENOG4108J9Q DNA ligase KS08_10720 ENOG4107D0N KS08_10800 ENOG4107NTZ KS08_10830 ENOG4108ZUE Phage regulatory protein rha KS08_10835 ENOG4105C4R Atp-dependent dna helicase KS08_10855 ENOG4108NE4 KS08_10890 ENOG4105ZUG KS08_10895 ENOG4105K70 DNA-binding protein KS08_10910 ENOG4106QVS KS08_10990 ENOG41068G1 KS08_11030 ENOG4105D9P serine threonine protein kinase KS08_11080 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KS08_11110 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KS08_11140 ENOG4106BHF KS08_11155 ENOG4107Y9E nuclease KS08_11165 ENOG4105C2W permease KS08_11170 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) KS08_11175 ENOG4105CTD carboxy-peptidase KS08_11180 ENOG4105DVT helicase KS08_11195 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) KS08_11200 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) KS08_11205 ENOG4108UKS UPF0398 protein KS08_11215 ENOG4107X2U Inherit from COG: Exonuclease-like protein KS08_11220 ENOG4108I5C dEAD DEAH box helicase KS08_11265 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) KS08_11270 ENOG4105BZ4 penicillin-binding protein KS08_11280 ENOG4105CSM endonuclease III KS08_11290 ENOG4105C5S asparaginyl-tRNA synthetase KS08_11295 ENOG4105CHM Aminotransferase KS08_11305 ENOG4105YAC KS08_11310 ENOG4105DVT helicase KS08_11315 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) KS08_11325 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) KS08_11335 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate KS08_11340 ENOG4105CPK Glycosyl transferase (Group 1 KS08_11345 ENOG4105FJR Lmbe family KS08_11350 ENOG4108Z5K methylglyoxal synthase KS08_11355 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) KS08_11360 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase KS08_11365 ENOG4108JYZ YitT family KS08_11370 ENOG4105F0F Oxalate decarboxylase KS08_11390 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) KS08_11410 ENOG41068YB TPR repeat-containing protein KS08_11415 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase KS08_11425 ENOG4105CIH Imidazole acetol-phosphate transaminase KS08_11435 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) KS08_11440 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase KS08_11445 ENOG4105DK0 Indole-3-glycerol phosphate synthase KS08_11455 ENOG4105CRQ synthase (Component I) KS08_11460 ENOG4105KHN chorismate mutase KS08_11470 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase KS08_11475 ENOG4105BZU Histidine kinase KS08_11480 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) KS08_11485 ENOG4105EAH synthase KS08_11490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KS08_11495 ENOG4105XXQ heptaprenyl diphosphate synthase component I KS08_11500 ENOG4105WP2 Tryptophan RNA-binding attenuator protein KS08_11505 ENOG4105EUJ GTP cyclohydrolase i KS08_11510 ENOG4105K70 DNA-binding protein KS08_11515 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) KS08_11530 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase KS08_11535 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) KS08_11555 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) KS08_11560 ENOG4105CAT Cytidine monophosphate kinase KS08_11575 ENOG4105MSI germination protein ypeb KS08_11585 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) KS08_11590 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase KS08_11605 ENOG4107RGJ metallophosphoesterase KS08_11620 ENOG4105I7S Abortive infection protein KS08_11625 ENOG4105C9U ATP-dependent DNA helicase RecQ KS08_11630 ENOG4105T7X KS08_11640 ENOG4108SAX Membrane KS08_11645 ENOG4108JQ1 Dehydrogenase KS08_11660 ENOG4105BZU Histidine kinase KS08_11665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS08_11670 ENOG4105CRE cytochrome C KS08_11675 ENOG4107TWT Cytochrome c biogenesis protein KS08_11685 ENOG4105FE9 pseudouridine synthase KS08_11695 ENOG4108JIC nucleoside recognition domain protein KS08_11700 ENOG4105DZ1 carboxypeptidase KS08_11710 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) KS08_11715 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) KS08_11730 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) KS08_11735 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) KS08_11740 ENOG4108R6K riboflavin synthase, subunit alpha KS08_11765 ENOG4107ZE5 PPIases accelerate the folding of proteins KS08_11770 ENOG4105PTM secreted protein KS08_11775 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KS08_11785 ENOG4105G6R Stage v sporulation protein ae KS08_11795 ENOG4105CZ3 stage V sporulation protein ad KS08_11800 ENOG41090VF Stage v sporulation protein ac KS08_11815 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS08_11820 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KS08_11825 ENOG41082AN stage II sporulation protein KS08_11830 ENOG4105DZ1 carboxypeptidase KS08_11835 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) KS08_11845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KS08_11855 ENOG4105I3K Ferric uptake regulator, Fur family KS08_11860 ENOG4105MZ9 stage II sporulation protein m KS08_11880 ENOG4105DFD Na H antiporter KS08_11885 ENOG4108IJ0 Aspartate ammonia-lyase KS08_11890 ENOG4105HDK L-asparaginase KS08_11895 ENOG4108IMY Transcriptional regulator KS08_11905 ENOG4108YZ4 nudix hydrolase KS08_11915 ENOG4105CPC Aldo Keto reductase KS08_11935 ENOG4106HZJ KS08_11940 ENOG4105RHY Pfam:UPF0157 KS08_11945 ENOG4108XET gCN5-related N-acetyltransferase KS08_11950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KS08_11965 ENOG4105C02 permease KS08_11970 ENOG4105CS9 pantothenic acid kinase KS08_11980 ENOG4108IXY short-chain dehydrogenase reductase KS08_11985 ENOG41069FQ Metallo-beta-lactamase superfamily KS08_11990 ENOG4105II7 pyrroline-5-carboxylate reductase KS08_12000 ENOG4108K70 Transcriptional regulator KS08_12010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KS08_12020 ENOG410861F 50S ribosomal protein L33 KS08_12025 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) KS08_12030 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KS08_12035 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) KS08_12040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KS08_12050 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) KS08_12055 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KS08_12060 ENOG4108HNZ carboxyl transferase KS08_12065 ENOG4108ZVT methylmalonyl-coA epimerase KS08_12075 ENOG4108VZI ErfK ybiS ycfS ynhG family protein KS08_12080 ENOG4108QEG Membrane KS08_12085 ENOG4105CDA abc transporter atp-binding protein KS08_12090 ENOG4105E5Q amino acid AbC transporter KS08_12095 ENOG4108HW3 (ABC) transporter KS08_12100 ENOG4108Y6J UPF0403 protein KS08_12105 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) KS08_12110 ENOG4105C7S Dehydrogenase KS08_12115 ENOG4105CPP Dehydrogenase, E1 component KS08_12130 ENOG4105CKM Branched-chain carboxylic acid kinase KS08_12135 ENOG4107RDP Dehydrogenase KS08_12145 ENOG4108JUB Transcriptional regulator KS08_12150 ENOG4106CCJ Protein of unknown function (DUF2627) KS08_12155 ENOG4105CR4 methylisocitrate lyase KS08_12160 ENOG4105DXD 2-methylcitrate dehydratase KS08_12170 ENOG4105C1G acyl-Coa dehydrogenase KS08_12175 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KS08_12185 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KS08_12190 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KS08_12215 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KS08_12230 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KS08_12235 ENOG4107QQR Sporulation KS08_12245 ENOG4105S1Z Stage IV sporulation protein B KS08_12250 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) KS08_12255 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) KS08_12260 ENOG4105DX0 Hemolysin A KS08_12265 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) KS08_12270 ENOG4105CTB Polyprenyl synthetase KS08_12275 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KS08_12280 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KS08_12285 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) KS08_12290 ENOG4105M7K Involved in the transcription termination process (By similarity) KS08_12295 ENOG4108ZSR alkaline shock protein KS08_12300 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KS08_12320 ENOG410644B Stage III sporulation protein af KS08_12330 ENOG4105KQ4 Stage iii sporulation protein ad KS08_12335 ENOG4108CQH stage III sporulation protein AC KS08_12340 ENOG4105KR5 Stage iii sporulation protein KS08_12345 ENOG4105CD2 stage iii sporulation protein aa KS08_12355 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) KS08_12360 ENOG4105DC7 peptidase M24 KS08_12370 ENOG4105CBJ Metal-dependent enzyme KS08_12390 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) KS08_12395 ENOG4105WZW rhodanese family KS08_12400 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor KS08_12410 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KS08_12415 ENOG4105C0D helicase KS08_12430 ENOG4108IMY Transcriptional regulator KS08_12440 ENOG4105VFR signal peptidase KS08_12500 ENOG4105C37 (CBS) domain KS08_12525 ENOG4105C5X domain protein KS08_12570 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase KS08_12575 ENOG4105WDJ 50S ribosomal protein L33 KS08_12585 ENOG41068DG YceG-like family KS08_12590 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KS08_12595 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KS08_12600 ENOG4105E2Z phosphate ABC transporter (Permease KS08_12605 ENOG4105C8U phosphate abc transporter KS08_12610 ENOG4105CVA phosphate KS08_12615 ENOG4107RF6 penicillin-binding protein KS08_12625 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KS08_12630 ENOG4105SXS Protein of unknown function (DUF456) KS08_12645 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) KS08_12650 ENOG41063Y9 KS08_12655 ENOG4108U5J '-nucleotidase KS08_12660 ENOG4105N80 Ferric uptake regulator, Fur family KS08_12665 ENOG4108JYZ YitT family KS08_12670 ENOG41069ZM Protein of unknown function (DUF2624) KS08_12675 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) KS08_12690 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) KS08_12695 ENOG4105EGD dinuclear metal center protein, YbgI family KS08_12710 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS08_12715 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) KS08_12720 ENOG4108UPT UPF0178 protein KS08_12725 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) KS08_12735 ENOG4105C38 Glycyl-tRNA synthetase beta subunit KS08_12740 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit KS08_12745 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) KS08_12755 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) KS08_12760 ENOG4105KG3 cytidine deaminase KS08_12765 ENOG4107YR5 Diacylglycerol kinase KS08_12770 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) KS08_12775 ENOG4105CTJ Metal Dependent Phosphohydrolase KS08_12780 ENOG4105C9A Phoh family KS08_12785 ENOG4105EI1 sporulation protein yqfd KS08_12790 ENOG41068P3 sporulation protein YqfC KS08_12800 ENOG4105DI5 UPF0365 protein KS08_12805 ENOG4105F7J membrane-bound serine protease KS08_12810 ENOG4105KTH gatB Yqey KS08_12825 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KS08_12830 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) KS08_12835 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) KS08_12840 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) KS08_12845 ENOG4105CFG Acts as a chaperone (By similarity) KS08_12850 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KS08_12855 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) KS08_12860 ENOG4105CSA Coproporphyrinogen iii oxidase KS08_12865 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) KS08_12875 ENOG4108ZRV stage ii sporulation protein p KS08_12880 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) KS08_12885 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) KS08_12890 ENOG4105TQK DNA polymerase iii, delta' subunit KS08_12900 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KS08_12905 ENOG4108UK2 deaminase KS08_12910 ENOG4105KQC Competence protein KS08_12920 ENOG4108D32 Methyltransferase KS08_12930 ENOG4108WF2 Metal Dependent Phosphohydrolase KS08_12935 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) KS08_12940 ENOG410812S Rna-binding protein KS08_12945 ENOG4105E2X shikimate dehydrogenase KS08_12950 ENOG4105CQW ribosome biogenesis GTPase YqeH KS08_12955 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase KS08_12975 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KS08_12980 ENOG41080BT SNARE associated Golgi KS08_12995 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS08_13015 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS08_13020 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KS08_13030 ENOG4108J8C transporter major facilitator family protein KS08_13040 ENOG4108HCJ Hydrolase KS08_13045 ENOG4108HCJ Hydrolase KS08_13055 ENOG4105DG6 mannose-6-phosphate isomerase KS08_13060 ENOG4105DM4 PTS System KS08_13075 ENOG4108Z66 YbaK ebsC protein KS08_13080 ENOG4107RSM transcriptional regulator KS08_13085 ENOG4105D94 Major Facilitator Superfamily KS08_13090 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KS08_13095 ENOG41082JN Transcriptional regulator KS08_13110 ENOG4105TMB Formate nitrite transporter KS08_13115 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) KS08_13120 ENOG4108JB9 formate dehydrogenase KS08_13135 ENOG4105C28 cystathionine KS08_13165 ENOG4107XRG penicillin-binding protein KS08_13170 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) KS08_13180 ENOG4105CFP Peptidase U32 KS08_13185 ENOG4105XYU peptidase (U32 family) KS08_13190 ENOG4108VQJ O-methyltransferase KS08_13195 ENOG4105HHA aminodeoxychorismate lyase KS08_13205 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) KS08_13210 ENOG4105VBH UPF0297 protein KS08_13215 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KS08_13220 ENOG4105C02 permease KS08_13225 ENOG4105CDA abc transporter atp-binding protein KS08_13230 ENOG4105CT1 (ABC) transporter KS08_13235 ENOG4105EAD ABC transporter KS08_13240 ENOG4105DRP amino acid AbC transporter KS08_13250 ENOG41060CR KS08_13260 ENOG4105C7H Helicase, RecD TraA family KS08_13270 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) KS08_13275 ENOG4105C3J Cysteine desulfurase KS08_13285 ENOG4105D1H recombination factor protein RarA KS08_13290 ENOG4105CUZ uba thif-type nad fad binding protein KS08_13300 ENOG4105C9M aspartyl-trna synthetase KS08_13305 ENOG4105CUT histidyl-tRNA synthetase KS08_13320 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KS08_13325 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) KS08_13330 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) KS08_13340 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) KS08_13345 ENOG41067VP Protein of unknown function (DUF1049) KS08_13350 ENOG4105NCW Trka-c domain protein KS08_13355 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KS08_13365 ENOG4105CKP Polysaccharide Biosynthesis Protein KS08_13370 ENOG4108QG2 Membrane KS08_13375 ENOG4105NAP KS08_13380 ENOG4105VIE preprotein translocase, subunit YajC KS08_13385 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) KS08_13390 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) KS08_13395 ENOG41061AI Protein of unknown function (DUF2905) KS08_13400 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) KS08_13405 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) KS08_13420 ENOG4106678 morphogenetic protein associated with SpoVID KS08_13425 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) KS08_13430 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase KS08_13435 ENOG4108IYU L-aspartate oxidase KS08_13450 ENOG4105CQC Prephenate dehydratase KS08_13460 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KS08_13470 ENOG4105K46 50S ribosomal protein l27 KS08_13475 ENOG4105X36 (ribosomal) protein KS08_13480 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) KS08_13495 ENOG4107QMS site-determining protein KS08_13500 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) KS08_13505 ENOG4105YHC Rod shape-determining protein MreD KS08_13510 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) KS08_13515 ENOG4105DFF Rod shape-determining protein mreb KS08_13520 ENOG4105W5Q DNA repair protein (RadC KS08_13525 ENOG4108Z03 MAF-like protein KS08_13535 ENOG4106A3R peptidase KS08_13540 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase KS08_13545 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) KS08_13555 ENOG4106AR7 Spore coat protein KS08_13560 ENOG41068KH stage VI sporulation protein D KS08_13565 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KS08_13570 ENOG4105D52 delta-aminolevulinic acid dehydratase KS08_13580 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) KS08_13590 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) KS08_13600 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) KS08_13605 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) KS08_13610 ENOG4108IUQ atp-dependent protease KS08_13615 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) KS08_13620 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation KS08_13630 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KS08_13635 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KS08_13640 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KS08_13650 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KS08_13655 ENOG4108ZP8 Acetolactate synthase small subunit KS08_13660 ENOG4105C7K acetolactate synthase KS08_13685 ENOG4105M59 Phosphodiesterase, mj0936 family KS08_13690 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) KS08_13695 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) KS08_13700 ENOG4108XJQ germination protein KS08_13705 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KS08_13710 ENOG41067TZ transcriptional regulator, MarR family KS08_13715 ENOG4105PFC Transcriptional regulator KS08_13725 ENOG4105E33 succinate dehydrogenase KS08_13735 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit KS08_13750 ENOG4105CFH Aspartokinase KS08_13755 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) KS08_13760 ENOG4105K63 Thioredoxin KS08_13765 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KS08_13770 ENOG4105C10 Electron transfer flavoprotein KS08_13775 ENOG4105BZJ Electron transfer flavoprotein KS08_13780 ENOG41060WC Enoyl-CoA hydratase KS08_13785 ENOG4107Z3H Transcriptional regulator, TetR family KS08_13790 ENOG4105CEY Amp-dependent synthetase and ligase KS08_13795 ENOG4108YV3 Protein of unknown function (DUF2711) KS08_13805 ENOG4105C98 muts2 protein KS08_13810 ENOG4105DCG PHP domain protein KS08_13825 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KS08_13830 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) KS08_13835 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) KS08_13840 ENOG4108RWN rrna methyltransferase KS08_13845 ENOG41067MF small acid-soluble spore protein KS08_13855 ENOG4105CQB FAD linked oxidase domain protein KS08_13860 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KS08_13870 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KS08_13875 ENOG4105DRS transport system, permease KS08_13890 ENOG4108MDK Dehydrogenase KS08_13900 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase KS08_13905 ENOG4105EF1 ribulokinase KS08_13915 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase KS08_13920 ENOG4105CN9 Peptidase m42 family protein KS08_13930 ENOG410696E Membrane KS08_13935 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) KS08_13940 ENOG4105VJV 50s ribosomal protein L35 KS08_13945 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) KS08_13950 ENOG41067MG lrgb family KS08_13960 ENOG4105DY9 regulatoR KS08_13965 ENOG4108HRK Histidine kinase KS08_13970 ENOG4105U0R haloacid dehalogenase-like hydrolase KS08_13975 ENOG4105C22 threonyL-tRNA synthetase KS08_13980 ENOG4108TDW sporulation protein YtxC KS08_14005 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KS08_14010 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KS08_14015 ENOG4105KVH Transcriptional regulator KS08_14020 ENOG4105F27 Major Facilitator KS08_14025 ENOG4105CV8 reductase KS08_14030 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) KS08_14040 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) KS08_14045 ENOG4105C2M dna polymerase I KS08_14050 ENOG4105BZU Histidine kinase KS08_14055 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS08_14065 ENOG4108HMX isocitrate dehydrogenase (NADP) KS08_14070 ENOG4105BZN citrate synthase KS08_14080 ENOG4108REF Sporulation integral membrane protein ytvi KS08_14085 ENOG4105FS0 cytoplasmic membrane protein KS08_14090 ENOG4105CA9 Pyruvate kinase KS08_14095 ENOG4105CTQ phosphohexokinase KS08_14100 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) KS08_14105 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) KS08_14115 ENOG4105C6K Malic enzyme KS08_14120 ENOG4105C0B DNA polymerase III (alpha subunit) KS08_14125 ENOG4105VV2 KS08_14135 ENOG4106EVM KS08_14140 ENOG4105SFS phosphoesterase RecJ domain protein KS08_14155 ENOG4105E8R UPF0173 metal-dependent hydrolase KS08_14170 ENOG4105CH7 arginosuccinase KS08_14175 ENOG4105CDH Citrulline--aspartate ligase KS08_14180 ENOG4105EPU Molybdenum cofactor synthesis domain protein KS08_14185 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KS08_14195 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) KS08_14200 ENOG4105KBJ sporulation protein ytfj KS08_14210 ENOG4105VK3 rdd domain containing protein KS08_14215 ENOG4105D07 Signal peptide peptidase, SppA KS08_14220 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KS08_14225 ENOG4105EFZ amidohydrolase KS08_14230 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KS08_14240 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) KS08_14265 ENOG4105U5Y Transcriptional regulator KS08_14275 ENOG4105BZU Histidine kinase KS08_14280 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) KS08_14285 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KS08_14295 ENOG4108Z0Z intracellular protease Pfpi family KS08_14315 ENOG4108NGU Transcriptional regulator KS08_14320 ENOG4108UMN azlc family KS08_14330 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KS08_14340 ENOG4105F1V Acetoin utilization protein KS08_14345 ENOG4105W87 Cbs domain KS08_14350 ENOG4105DGU Histone deacetylase KS08_14355 ENOG4105ER2 Ompa motb domain protein KS08_14360 ENOG4107R0U MotA TolQ exbB proton channel KS08_14365 ENOG4105ETE Transcriptional regulator (LacI family KS08_14370 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase KS08_14390 ENOG4105DFU Cell wall formation (By similarity) KS08_14400 ENOG4108VDD TRNA binding domain protein KS08_14415 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ KS08_14430 ENOG4105C6K Malic enzyme KS08_14435 ENOG4105C8F Beta-lactamase domain protein KS08_14440 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) KS08_14450 ENOG4108V15 phosphotransferase enzyme family KS08_14465 ENOG4107F58 2'-5' rna ligase KS08_14470 ENOG4105C6T cysteine synthase KS08_14475 ENOG4107QSE Dipeptidase KS08_14480 ENOG4105C7N Xanthine uracil vitamin C permease KS08_14495 ENOG4105YW5 deoR family transcriptional regulator KS08_14510 ENOG4105CBX hi0933 family KS08_14515 ENOG4105C94 Transporter KS08_14535 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component KS08_14540 ENOG4105I1K ABC transporter KS08_14555 ENOG41085GJ domain protein KS08_14560 ENOG4105C8T Leucyl-tRNA synthetase KS08_14570 ENOG4105BZU Histidine kinase KS08_14575 ENOG410605W Major Facilitator KS08_14590 ENOG4105C19 ABC transporter KS08_14595 ENOG4105EWM Histidine kinase KS08_14605 ENOG4107R34 abc transporter permease protein KS08_14610 ENOG4105C19 ABC transporter KS08_14630 ENOG4105DVE abc transporter atp-binding protein KS08_14635 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KS08_14650 ENOG4105N5T Radical SAM Protein KS08_14670 ENOG4105E8V Alpha Beta Hydrolase Fold protein KS08_14675 ENOG4108Z0R Transferase KS08_14680 ENOG4105C85 amino acid KS08_14685 ENOG4105CAQ asparagine synthetase KS08_14690 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP KS08_14695 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase KS08_14710 ENOG4105D2X ABC transporter substrate-binding protein KS08_14720 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component KS08_14735 ENOG4108RMU ferritin dps family protein KS08_14750 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) KS08_14755 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) KS08_14760 ENOG4108V2W Carbonate dehydratase KS08_14765 ENOG4105NRA 50s ribosomal protein l31 type b KS08_14785 ENOG4105DTQ mandelate racemase muconate lactonizing KS08_14790 ENOG4105CEY Amp-dependent synthetase and ligase KS08_14795 ENOG4108IPT Naphthoate synthase KS08_14800 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) KS08_14805 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) KS08_14810 ENOG4105E4F Isochorismate synthase KS08_14945 ENOG4105N67 Proton-coupled thiamine transporter YuaJ KS08_14950 ENOG4105DZ6 Band 7 protein KS08_14960 ENOG4106DF1 KS08_14965 ENOG4108VNY MOSC domain protein KS08_14970 ENOG4108JB8 alcohol dehydrogenase KS08_14975 ENOG4105C26 Dehydrogenase KS08_14980 ENOG4105TRT Transcriptional regulator KS08_14995 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KS08_15000 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KS08_15075 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KS08_15095 ENOG41068G1 KS08_15115 ENOG4108FKH Transglycosylase SLT domain KS08_15250 ENOG4105VTR Integrase KS08_15260 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KS08_15270 ENOG4105EE0 oxidoreductase KS08_15275 ENOG4108Z0Z intracellular protease Pfpi family KS08_15280 ENOG4105C8Q Methyl-accepting chemotaxis KS08_15285 ENOG4105C8Q Methyl-accepting chemotaxis KS08_15290 ENOG4105C8Q Methyl-accepting chemotaxis KS08_15295 ENOG4105C8Q Methyl-accepting chemotaxis KS08_15310 ENOG4105EA8 2-Nitropropane dioxygenase KS08_15325 ENOG4105C37 (CBS) domain KS08_15340 ENOG4107PBV potassium channel KS08_15345 ENOG4107PBV potassium channel KS08_15360 ENOG4107QYV phosphohexose isomerase KS08_15370 ENOG4107QW4 alcohol dehydrogenase KS08_15375 ENOG4105WG9 Conserved Protein KS08_15385 ENOG4105CHM Aminotransferase KS08_15390 ENOG4108ZB6 transcriptional regulator AsnC family KS08_15395 ENOG4108MUZ hydrolase KS08_15405 ENOG4105C87 Aminotransferase class I and II KS08_15410 ENOG4108HGU Histidine kinase KS08_15415 ENOG4105Y38 Kinase-associated protein B KS08_15430 ENOG4105BZ4 penicillin-binding protein KS08_15435 ENOG4105KIR Thiol-disulfide oxidoreductase dcc KS08_15450 ENOG4108MRH transcriptional regulatory protein KS08_15455 ENOG4105DIH basic membrane KS08_15460 ENOG4108JQ9 ABC transporter KS08_15465 ENOG4105UIB (ABC) transporter KS08_15480 ENOG4105D65 subunit l KS08_15485 ENOG4105HC0 Na H antiporter KS08_15490 ENOG4108ZE9 Monovalent cation H antiporter subunit C KS08_15495 ENOG4108JPZ Monovalent cation H antiporter subunit D KS08_15500 ENOG4105SC1 monovalent cation H antiporter subunit E KS08_15510 ENOG4105KJM monovalent cation h antiporter subunit g KS08_15515 ENOG4105KA0 thioesterase Superfamily protein KS08_15525 ENOG4105BZU Histidine kinase KS08_15550 ENOG4105D58 Diguanylate phosphodiesterase KS08_15555 ENOG4105DAP Nicotinate phosphoribosyltransferase KS08_15580 ENOG4105C02 permease KS08_15595 ENOG410904N short-chain dehydrogenase reductase KS08_15630 ENOG4108K8K Transcriptional regulator KS08_15635 ENOG4105DCF alanine dehydrogenase KS08_15645 ENOG4105WQT MbtH domain protein KS08_15650 ENOG4105CEY Amp-dependent synthetase and ligase KS08_15655 ENOG4105WQI isochorismatase KS08_15660 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase KS08_15665 ENOG4105E4F Isochorismate synthase KS08_15670 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase KS08_15675 ENOG4105NIV Esterase KS08_15695 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) KS08_15705 ENOG41069ER domain protein KS08_15715 ENOG4105CEP NADH dehydrogenase KS08_15725 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) KS08_15770 ENOG4108VHC Short-chain dehydrogenase reductase Sdr KS08_15790 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KS08_15810 ENOG41068G1 KS08_15825 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KS08_16015 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KS08_16020 ENOG4108YX9 iron--sulfur cluster insertion protein erpA KS08_16025 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) KS08_16035 ENOG4105ZKE UPF0349 protein KS08_16050 ENOG41083MR nifu domain-containing protein KS08_16055 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein KS08_16060 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) KS08_16065 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) KS08_16070 ENOG4105D6E homoserine dehydrogenase KS08_16080 ENOG4108W5N phosphatidylglycerophosphatase a KS08_16085 ENOG4105D4U had-superfamily hydrolase, subfamily iia KS08_16095 ENOG4105MMD transcriptional regulator KS08_16100 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) KS08_16105 ENOG4105FAA peptidase M23 KS08_16110 ENOG4108YTE sporulation protein YunB KS08_16115 ENOG4107R8B 5'-nucleotidase KS08_16125 ENOG4105I3N Conserved Protein KS08_16135 ENOG4105CD3 dihydroorotase KS08_16140 ENOG4105G9B Transcriptional regulator KS08_16155 ENOG4105C5R Aminotransferase KS08_16165 ENOG4108K8S endonuclease I KS08_16170 ENOG4108IJ9 (ABC) transporter KS08_16175 ENOG4105FDP GntR family transcriptional regulator KS08_16180 ENOG4108KPW sugar kinase KS08_16185 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component KS08_16190 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component KS08_16195 ENOG4105XN3 extracellular solute-binding protein family 1 KS08_16200 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine KS08_16230 ENOG4105PKS Excinuclease abc c subunit domain protein KS08_16235 ENOG4107VFR oxidoreductase KS08_16250 ENOG41083Q9 chitosanase KS08_16255 ENOG4105DIW FeS assembly protein SUFB KS08_16260 ENOG4108UNV SUF system FeS assembly protein, NifU family KS08_16265 ENOG4105C9B Cysteine desulfurase KS08_16270 ENOG4105JRK feS assembly protein SufD KS08_16275 ENOG4105C3K feS assembly ATPase SufC KS08_16290 ENOG4105D01 (LipO)protein KS08_16295 ENOG4108UMI ABC transporter, permease KS08_16300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KS08_16325 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) KS08_16330 ENOG41080E8 Transcriptional regulator, Spx MgsR family KS08_16335 ENOG4105C1G acyl-Coa dehydrogenase KS08_16340 ENOG4105CHU acetyl-coa acetyltransferase KS08_16370 ENOG41067TZ transcriptional regulator, MarR family KS08_16375 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS08_16400 ENOG4105E0A ABC, transporter KS08_16415 ENOG4105E1F short-chain dehydrogenase reductase KS08_16420 ENOG4105HUF DNA protection during starvation protein KS08_16425 ENOG4105C0H protease KS08_16435 ENOG4105F3H Histidine kinase KS08_16445 ENOG41067SE Tetr family transcriptional regulator KS08_16450 ENOG4105C9Q fumarate hydratase class II KS08_16475 ENOG4105WH1 Two component transcriptional regulator luxr family KS08_16480 ENOG4105ENE Histidine kinase KS08_16495 ENOG41087YS Phage shock protein A KS08_16510 ENOG4108WBT adenosyltransferase KS08_16515 ENOG4105E0A ABC, transporter KS08_16520 ENOG4105EHG Permease protein KS08_16525 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) KS08_16530 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KS08_16535 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein KS08_16545 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS08_16555 ENOG4106DF4 Sigma-70, region 4 KS08_16565 ENOG4105F0F Oxalate decarboxylase KS08_16575 ENOG4105E0A ABC, transporter KS08_16580 ENOG4105EHG Permease protein KS08_16585 ENOG4105DQ5 transport system permease protein KS08_16595 ENOG4105JQZ Methyltransferase KS08_16600 ENOG4105D5Q Arginine ornithine antiporter KS08_16610 ENOG4107K5X Membrane-bound metal-dependent hydrolase KS08_16615 ENOG4107QZ2 Sulfatase KS08_16620 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family KS08_16625 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KS08_16630 ENOG4105E0C molybdate abc transporter KS08_16635 ENOG4105WH1 Two component transcriptional regulator luxr family KS08_16645 ENOG4105CJ1 ABC, transporter KS08_16655 ENOG4108KYE ABC-2 type transporter KS08_16670 ENOG4105EEQ Na H antiporter KS08_16675 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) KS08_16680 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KS08_16685 ENOG4105EEM helicase KS08_16690 ENOG4105EN6 Membrane KS08_16705 ENOG4107ZQN disulfide bond KS08_16710 ENOG4105C59 p-type ATPase KS08_16715 ENOG4105C59 p-type ATPase KS08_16720 ENOG410681U heavy metal transport detoxification protein KS08_16725 ENOG4105VPX protein, conserved in bacteria KS08_16730 ENOG4105D9R oxidoreductase KS08_16735 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KS08_16750 ENOG4105DEN Luciferase family KS08_16755 ENOG4105CDA abc transporter atp-binding protein KS08_16780 ENOG4108XSB acetyltransferase, (GNAT) family KS08_16785 ENOG4108KSA LysR family transcriptional regulator KS08_16790 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KS08_16795 ENOG41067XF inhibitor KS08_16800 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) KS08_16805 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) KS08_16815 ENOG4105XZU Preprotein translocase, subunit SecG KS08_16835 ENOG4105KVH Transcriptional regulator KS08_16860 ENOG4105DA5 (ABC) transporter KS08_16865 ENOG4105R40 Glycine betaine carnitine choline KS08_16870 ENOG4108HQR Glycine betaine KS08_16875 ENOG4105E90 ABC transporter KS08_16880 ENOG4108IJ8 ABC transporter KS08_16885 ENOG4107HG4 Transcriptional regulator KS08_16890 ENOG4105R40 Glycine betaine carnitine choline KS08_16895 ENOG4108HQR Glycine betaine KS08_16900 ENOG4105E90 ABC transporter KS08_16905 ENOG4108IJ8 ABC transporter KS08_16910 ENOG4107HG4 Transcriptional regulator KS08_16915 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein KS08_16930 ENOG4108W0I acetyltransferase KS08_16945 ENOG4105FJR Lmbe family KS08_16965 ENOG4108IAJ Nad-dependent epimerase dehydratase KS08_16970 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KS08_16975 ENOG4107QQG Dehydrogenase KS08_16980 ENOG4105IIU Aminopeptidase KS08_16985 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) KS08_16990 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) KS08_16995 ENOG4105CP7 Triose-phosphate isomerase KS08_17000 ENOG4105BZA Phosphoglycerate kinase KS08_17010 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KS08_17025 ENOG4105CMD Transcriptional regulator, GntR family KS08_17030 ENOG4105DEN Luciferase family KS08_17035 ENOG4105GZI Transcriptional regulator KS08_17040 ENOG4107RT3 EamA-like transporter family KS08_17050 ENOG4106KNT transcriptional regulator KS08_17055 ENOG4105CMG Carbohydrate kinase KS08_17060 ENOG4105C6Z Gluconate KS08_17070 ENOG4107QR9 Iron-sulfur cluster binding protein KS08_17075 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KS08_17085 ENOG4105JXH GntR family transcriptional regulator KS08_17090 ENOG4105DAA L-lactate KS08_17095 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS08_17105 ENOG4108ZPC Polysaccharide pyruvyl transferase KS08_17110 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KS08_17115 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family KS08_17120 ENOG4105D3Q Sugar transferase KS08_17130 ENOG4105K64 Glycosyl transferase, family 2 KS08_17140 ENOG4107QRS glycosyltransferase group 2 family protein KS08_17145 ENOG41068W6 Capsular polysaccharide biosynthesis protein KS08_17150 ENOG4108KMV Glycosyl transferase (Group 1 KS08_17155 ENOG4105K64 Glycosyl transferase, family 2 KS08_17160 ENOG4108PQP glycosyl transferase group 1 KS08_17170 ENOG4108QV3 biosynthesis protein KS08_17175 ENOG4105HTX biosynthesis protein KS08_17185 ENOG4105EBR Carboxylesterase KS08_17195 ENOG4105NAE bifunctional deaminase-reductase domain protein KS08_17200 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) KS08_17215 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 KS08_17220 ENOG4105PY6 Phenolic acid decarboxylase KS08_17225 ENOG4105NI3 Protein of unknown function (DUF3237) KS08_17260 ENOG4108HKT sucrose-6-phosphate hydrolase KS08_17265 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) KS08_17270 ENOG4105ETE Transcriptional regulator (LacI family KS08_17275 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KS08_17280 ENOG4108KAM Transcriptional regulator KS08_17285 ENOG4105C7F AcnD-accessory protein PrpF KS08_17300 ENOG4108URH decarboxylase KS08_17305 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain KS08_17310 ENOG4105CHH sulfate transporter KS08_17315 ENOG4108V2W Carbonate dehydratase KS08_17325 ENOG4105C5I Dehydrogenase KS08_17330 ENOG4105GGE ribonuclease KS08_17335 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase KS08_17340 ENOG4105KRI phosphocarrier protein (HPr KS08_17345 ENOG4105CIE May be required for sporulation (By similarity) KS08_17350 ENOG4105CHW UPF0052 protein KS08_17355 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) KS08_17360 ENOG4108Z4K mutator MutT protein KS08_17365 ENOG4105C3M thioredoxin reductase KS08_17380 ENOG4105BZU Histidine kinase KS08_17385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS08_17390 ENOG4105BZ1 (ABC) transporter KS08_17395 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase KS08_17400 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) KS08_17405 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase KS08_17410 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) KS08_17415 ENOG4105ECC imidazole-glycerol-phosphate dehydratase KS08_17420 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) KS08_17425 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) KS08_17430 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) KS08_17440 ENOG4108S4C acetyltransferase KS08_17445 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) KS08_17455 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) KS08_17460 ENOG4105CE4 GlcNAc 6-P deacetylase KS08_17465 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) KS08_17470 ENOG4105FDP GntR family transcriptional regulator KS08_17475 ENOG4105J7D transcriptional regulator KS08_17480 ENOG41088CQ domain protein KS08_17485 ENOG41086DT Membrane protein of unknown function KS08_17490 ENOG41067S9 phage shock protein C, PspC KS08_17495 ENOG4108PY7 KS08_17510 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KS08_17515 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) KS08_17530 ENOG4105MKU Transcriptional regulator KS08_17560 ENOG4105CN1 protease KS08_17565 ENOG4108M26 parallel beta-helix repeat protein KS08_17570 ENOG4105CRP Part of the ABC transporter FtsEX involved in KS08_17575 ENOG4105CAK Cell division ATP-binding protein ftsE KS08_17590 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) KS08_17595 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving KS08_17600 ENOG4105MS2 ribosomal subunit Interface protein KS08_17615 ENOG4105MQ3 flagellar protein FliS KS08_17620 ENOG4107RT6 flagellar hook-associated KS08_17625 ENOG4105I03 Flagellin KS08_17630 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) KS08_17635 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) KS08_17645 ENOG4105DTJ flagellar hook-associated protein KS08_17650 ENOG4105E1Q flagellar hook-associated protein KS08_17665 ENOG4105RU3 KS08_17670 ENOG41081UC Inherit from COG: Competence protein KS08_17690 ENOG4105WH1 Two component transcriptional regulator luxr family KS08_17695 ENOG4105BZU Histidine kinase KS08_17700 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein KS08_17705 ENOG4108KGH TRANSCRIPTIONal KS08_17710 ENOG4105ESV Glycosyl transferase, family 4 KS08_17715 ENOG4107EF8 Glycosyl transferase (Group 1 KS08_17730 ENOG4105QZI O-Antigen Polymerase KS08_17735 ENOG4105C6Y Udp-glucose 6-dehydrogenase KS08_17740 ENOG4107RA4 Glycosyl transferase (Group 1 KS08_17745 ENOG4105PSV Polysaccharide Biosynthesis Protein KS08_17750 ENOG4105D3Q Sugar transferase KS08_17755 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KS08_17760 ENOG4105JFG SpoIID LytB domain protein KS08_17770 ENOG4108KGH TRANSCRIPTIONal KS08_17775 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase KS08_17780 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KS08_17785 ENOG4105EY8 ABC transporter KS08_17795 ENOG4107SJB teichoic acid biosynthesis KS08_17800 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) KS08_17805 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase KS08_17815 ENOG4107RZX Teichoic acid biosynthesis protein KS08_17825 ENOG4105DG6 mannose-6-phosphate isomerase KS08_17840 ENOG4108NHD germination protein KS08_17845 ENOG4108SHN Glycosyl transferase, family 2 KS08_17850 ENOG4105C54 Major Facilitator superfamily KS08_17855 ENOG4108KGH TRANSCRIPTIONal KS08_17860 ENOG4105J7I hydrolase KS08_17865 ENOG4106UBQ KS08_17870 ENOG4105K4H Nlp p60 protein KS08_17880 ENOG4105PNM synthesis protein KS08_17890 ENOG4105N98 Capsule biosynthesis protein capB KS08_17895 ENOG4105E1K spore germination protein KS08_17910 ENOG4105ETE Transcriptional regulator (LacI family KS08_17915 ENOG4108RVA ribokinase KS08_17920 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) KS08_17925 ENOG4105C2J ABC transporter KS08_17930 ENOG4105CNN ABC, transporter KS08_17935 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KS08_17945 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KS08_17950 ENOG4107FQX Alpha-acetolactate decarboxylase KS08_17960 ENOG4107RSM transcriptional regulator KS08_17975 ENOG4106UIA KS08_17990 ENOG4107XC4 flavin reductase domain protein, FMN-binding KS08_18000 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KS08_18010 ENOG4105CAH Chromate KS08_18015 ENOG4105FGV Chromate KS08_18060 ENOG4108XI2 Domain of unknown function (DUF1963) KS08_18065 ENOG4105C6Y Udp-glucose 6-dehydrogenase KS08_18070 ENOG4108RB3 Capsular polysaccharide biosynthesis protein KS08_18075 ENOG4107YJ4 chain length determinant protein KS08_18080 ENOG4105HTX biosynthesis protein KS08_18090 ENOG4105KBK Zinc finger, swim domain protein KS08_18095 ENOG4105C0D helicase KS08_18100 ENOG410667J hydrolase KS08_18105 ENOG4105E98 transcriptional regulator DeoR family KS08_18110 ENOG4105Z8H single-stranded DNA-binding protein KS08_18125 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) KS08_18130 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) KS08_18140 ENOG4105CGA flagellar basal-body rod protein FlgG KS08_18150 ENOG4105DFF Rod shape-determining protein mreb KS08_18155 ENOG4105MT0 Sporulation transcriptional regulator spoiiid KS08_18160 ENOG4107MII Sugar-specific transcriptional regulator TrmB KS08_18165 ENOG4105CZM Major Facilitator KS08_18170 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease KS08_18180 ENOG4105D3W isochorismatase KS08_18185 ENOG4105BZU Histidine kinase KS08_18195 ENOG4105CNI cell division protein FtsW KS08_18200 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase KS08_18210 ENOG4105FRN stage II sporulation protein KS08_18215 ENOG4107TCE N-acetyltransferase KS08_18230 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KS08_18240 ENOG4106BRK KS08_18245 ENOG4108RYK Nad-dependent epimerase dehydratase KS08_18250 ENOG4108Z40 Transcriptional regulator KS08_18255 ENOG4105CQM Urea amidohydrolase subunit alpha KS08_18260 ENOG4105KI2 Urea amidohydrolase subunit beta KS08_18265 ENOG4108YZ9 Urea amidohydrolase subunit gamma KS08_18285 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KS08_18290 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KS08_18300 ENOG4108TF4 von Willebrand factor, type A KS08_18315 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KS08_18325 ENOG4106778 Protein of unknown function (DUF1146) KS08_18335 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) KS08_18340 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) KS08_18345 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) KS08_18350 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) KS08_18355 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) KS08_18370 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) KS08_18380 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) KS08_18385 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) KS08_18390 ENOG4108UIC UPF0340 protein KS08_18395 ENOG4108YZG isomerase KS08_18400 ENOG4107WAU Protein tyrosine phosphatase KS08_18405 ENOG410815N Probably functions as a manganese efflux pump (By similarity) KS08_18410 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KS08_18420 ENOG4108ZXQ stage ii sporulation protein r KS08_18435 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KS08_18440 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) KS08_18445 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase KS08_18455 ENOG4107TT2 Auxin Efflux Carrier KS08_18460 ENOG4105C6K Malic enzyme KS08_18465 ENOG4107104 thymidine kinase KS08_18470 ENOG41082DI 50s ribosomal protein l31 KS08_18475 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) KS08_18480 ENOG4105CBT Fructose-1,6-bisphosphatase KS08_18485 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KS08_18495 ENOG4105D2N Aldolase KS08_18500 ENOG410812K response regulator receiver protein KS08_18510 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) KS08_18520 ENOG4105DF6 Fe-S oxidoreductase KS08_18530 ENOG4105E5J UV damage endonuclease KS08_18540 ENOG4105BZ1 (ABC) transporter KS08_18545 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KS08_18555 ENOG4105R3A Nitrate reductase KS08_18560 ENOG4108IUE nitrate reductase beta subunit KS08_18580 ENOG4107V6Q Cyclic nucleotide-binding domain KS08_18590 ENOG4105C75 arginyL-tRNA synthetase KS08_18595 ENOG410684U Domain of unknown function (DUF1934) KS08_18615 ENOG4107JM4 Tetratricopeptide repeat KS08_18625 ENOG4105CYW agmatinase KS08_18630 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) KS08_18635 ENOG4105BZ4 penicillin-binding protein KS08_18645 ENOG4108XFG YwhD family KS08_18650 ENOG4108Z4T Peptidase M50 KS08_18655 ENOG41069HH 4-oxalocrotonate tautomerase KS08_18660 ENOG41067TZ transcriptional regulator, MarR family KS08_18665 ENOG4105CUB amino acid KS08_18675 ENOG4105DCI Phosphohydrolase KS08_18685 ENOG4108VCI transcription factor, rsfa family KS08_18690 ENOG4105K7K Transcriptional regulator KS08_18705 ENOG4108TU7 Inherit from COG: (ABC) transporter KS08_18730 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) KS08_18735 ENOG4105DUM transcriptional regulator, lysR family KS08_18740 ENOG4105HMI Membrane KS08_18745 ENOG4108IJ2 phosphate acetyltransferase KS08_18750 ENOG4107JTW chlorite dismutase KS08_18760 ENOG4105CHM Aminotransferase KS08_18770 ENOG4108M32 ATP-grasp domain KS08_18785 ENOG41061WN bacilysin biosynthesis protein KS08_18790 ENOG4105FCW Major Facilitator superfamily KS08_18795 ENOG4105C2C drug resistance transporter, Bcr CflA KS08_18810 ENOG4105C26 Dehydrogenase KS08_18815 ENOG4105D82 Glutamate dehydrogenase KS08_18825 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase KS08_18830 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase KS08_18835 ENOG4105C1B dTDP-glucose 4-6-dehydratase KS08_18840 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) KS08_18845 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG KS08_18850 ENOG4107TY6 Acylneuraminate cytidylyltransferase KS08_18860 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD KS08_18865 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KS08_18900 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) KS08_18905 ENOG4108RJ9 Glycosyl transferase, family 2 KS08_18915 ENOG4105DWF phosphomethylpyrimidine kinase KS08_18930 ENOG4105C5Y PTS System KS08_18945 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin KS08_18950 ENOG4105DEN Luciferase family KS08_18955 ENOG4105D29 Helix-turn-helix type 11 domain protein KS08_18960 ENOG4107EXU Short-chain dehydrogenase reductase Sdr KS08_18975 ENOG4108DBC nitroreductase KS08_18985 ENOG4105I4A GCN5-related N-acetyltransferase KS08_19005 ENOG4105BZ9 Cytochrome C oxidase, subunit I KS08_19010 ENOG4105E2S oxidase) subunit II KS08_19015 ENOG4107BMA Transglycosylase associated protein KS08_19025 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) KS08_19030 ENOG4105WH5 Teichoic acid glycosylation protein KS08_19055 ENOG4107ZXU DSBA oxidoreductase KS08_19060 ENOG4105DBE peroxidase KS08_19065 ENOG410650H (LipO)protein KS08_19070 ENOG4107SJW iron permease, FTR1 KS08_19075 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) KS08_19080 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase KS08_19085 ENOG4105CMU LysR family (Transcriptional regulator KS08_19090 ENOG4105VAW lrga family KS08_19095 ENOG41067MG lrgb family KS08_19105 ENOG4107TXC Transcriptional regulator KS08_19115 ENOG4105DR4 Methyltransferase KS08_19125 ENOG4105CK1 PTS System KS08_19130 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin KS08_19135 ENOG4105X1N Glycosyl transferase family 8 KS08_19145 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase KS08_19160 ENOG4108NR7 pectate lyase KS08_19170 ENOG4107YZX Universal stress protein KS08_19175 ENOG4105CS2 ec 3.2.1.21 KS08_19180 ENOG4105C5Y PTS System KS08_19195 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) KS08_19220 ENOG4106Z5D Glycoside Hydrolase Family 43 KS08_19230 ENOG4105C84 Histidine ammonia-lyase KS08_19235 ENOG4105CGP Urocanate hydratase KS08_19240 ENOG4105CI2 imidazolone-5-propionate hydrolase KS08_19245 ENOG4107W25 arginase agmatinase formiminoglutamase KS08_19255 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KS08_19260 ENOG4105D9N nucleoside KS08_19265 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) KS08_19275 ENOG410667J hydrolase KS08_19305 ENOG4108V5C ABC transporter KS08_19340 ENOG4105WZ4 isomerase KS08_19345 ENOG4105F0H myo-inositol catabolism protein KS08_19350 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KS08_19360 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) KS08_19370 ENOG4105EDK PfkB domain protein KS08_19380 ENOG4105C26 Dehydrogenase KS08_19390 ENOG4105CPC Aldo Keto reductase KS08_19395 ENOG4107QNK )-transporter KS08_19400 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) KS08_19405 ENOG41061TZ Short-chain dehydrogenase reductase Sdr KS08_19410 ENOG4108S01 response regulator KS08_19415 ENOG4108ZGX Histidine kinase KS08_19420 ENOG4105ECK Fatty Acid Desaturase KS08_19425 ENOG4105ST3 Transcriptional regulator KS08_19430 ENOG4105C26 Dehydrogenase KS08_19435 ENOG4108ITS PQQ enzyme repeat KS08_19445 ENOG4105WAB arsR family transcriptional regulator KS08_19450 ENOG4105F27 Major Facilitator KS08_19455 ENOG41085PJ rdd domain containing protein KS08_19465 ENOG4105D3R alkyl hydroperoxide reductase KS08_19470 ENOG4108JU3 Alkyl hydroperoxide reductase KS08_19480 ENOG4105C85 amino acid KS08_19505 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 KS08_19510 ENOG4108XHQ (2Fe-2S)-binding domain protein KS08_19520 ENOG4105C7W Xanthine dehydrogenase KS08_19530 ENOG4105XRQ Xanthine dehydrogenase accessory factor KS08_19560 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) KS08_19575 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) KS08_19580 ENOG4105CPC Aldo Keto reductase KS08_19585 ENOG4105WQG acetyltransferase KS08_19595 ENOG41066UZ arginase EC 3.5.3.1 KS08_19600 ENOG4108IQI permease KS08_19605 ENOG4105C8Y Acetylornithine aminotransferase KS08_19615 ENOG41082BM Transcriptional regulator, arsr family KS08_19620 ENOG4108JUB Transcriptional regulator KS08_19635 ENOG41062D9 Histidine kinase KS08_19640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS08_19650 ENOG4105C0H protease KS08_19655 ENOG4105Q2H domain protein KS08_19670 ENOG4105BZU Histidine kinase KS08_19675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS08_19710 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase KS08_19715 ENOG4105CDU Replicative dna helicase KS08_19755 ENOG4105CGN Glycosyl transferase (Group 1 KS08_19775 ENOG4105BZR domain protein KS08_19780 ENOG4108XMW Membrane KS08_19795 ENOG4105KVH Transcriptional regulator KS08_19800 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase KS08_19805 ENOG4108UZ3 Transporter KS08_19810 ENOG4105EDQ levansucrase EC 2.4.1.10 KS08_19815 ENOG4108HKT sucrose-6-phosphate hydrolase KS08_19840 ENOG4108TVJ Nitroreductase KS08_19845 ENOG4105FS7 Transcriptional regulator KS08_19855 ENOG4108U05 Transcriptional regulator KS08_19860 ENOG41082BV acetyltransferase KS08_19875 ENOG4107Y9U Membrane KS08_19880 ENOG4105C7Z Conserved Protein KS08_19885 ENOG4107RRE RNA-directed DNA polymerase KS08_19890 ENOG4105C7Z Conserved Protein KS08_19895 ENOG4107FCW Abortive infection protein KS08_19905 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase KS08_19915 ENOG4105CGK Exodeoxyribonuclease III KS08_19920 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KS08_19930 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) KS08_19935 ENOG4108UUM single-stranded DNA-binding protein KS08_19940 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) KS08_19945 ENOG4105C3G gtp-binding protein KS08_19950 ENOG4108J2R molybdopterin oxidoreductase KS08_19955 ENOG4105VDK protein, conserved in bacteria KS08_19970 ENOG4108ZDA Sporulation protein YyaC KS08_19975 ENOG4105FA0 parb-like partition protein KS08_19980 ENOG4107QJE Chromosome Partitioning Protein KS08_19995 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) KS08_20000 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) KS08_20015 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)