locus-tag class description KS07_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) KS07_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) KS07_00015 ENOG410848D S4 domain protein YaaA KS07_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) KS07_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KS07_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KS07_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) KS07_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) KS07_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) KS07_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) KS07_00095 ENOG4105BZW Glycerate kinase KS07_00105 ENOG4105ZMH deoxynucleoside kinase KS07_00115 ENOG4105VRS hydrolase family 18 KS07_00120 ENOG4105GTG Isochorismatase KS07_00125 ENOG4108Z6B deaminase KS07_00130 ENOG4105C6E dna polymerase iii KS07_00135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) KS07_00140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) KS07_00150 ENOG41067KS pro-sigma K processing KS07_00190 ENOG4105CDW Resistance protein KS07_00195 ENOG4105CXN decarboxylase KS07_00200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) KS07_00205 ENOG4105X0R protein from nitrogen regulatory protein P-II KS07_00210 ENOG4105XVJ Protein of unknown function (DUF327) KS07_00215 ENOG4105FA2 dna polymerase iii KS07_00220 ENOG4105MA4 psp1 domain protein KS07_00230 ENOG41060K3 Methyltransferase KS07_00235 ENOG4105VC4 domain protein KS07_00240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) KS07_00245 ENOG4105KRN Transcriptional regulator, abrb family KS07_00250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) KS07_00255 ENOG4105F8V Hydrolase, tatD family KS07_00260 ENOG41069ER domain protein KS07_00270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) KS07_00275 ENOG4105XFA sporulation peptidase YabG KS07_00280 ENOG4105W42 Veg protein KS07_00285 ENOG4105XEW small acid-soluble spore protein KS07_00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) KS07_00295 ENOG4105DFT pur operon repressor KS07_00300 ENOG4105KME endoribonuclease L-psp KS07_00305 ENOG4105K4W Could be involved in septation (By similarity) KS07_00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) KS07_00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase KS07_00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) KS07_00335 ENOG4108JA2 transcriptioN-repair coupling factor KS07_00340 ENOG4108M14 stage v sporulation protein t KS07_00350 ENOG4108IY2 MazG family KS07_00355 ENOG41082I2 s4 domain protein KS07_00360 ENOG4105VYY sporulation protein yabp KS07_00375 ENOG41060GV RNA binding s1 domain protein KS07_00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) KS07_00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase KS07_00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KS07_00420 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) KS07_00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) KS07_00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase KS07_00435 ENOG4105C6T cysteine synthase KS07_00440 ENOG4105CRQ synthase (Component I) KS07_00445 ENOG4105DDQ anthranilate synthase KS07_00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 KS07_00455 ENOG4105EEI dihydropteroate synthase KS07_00460 ENOG4105KRF dihydroneopterin aldolase KS07_00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase KS07_00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KS07_00480 ENOG4105CRK lysyL-tRNA synthetase KS07_00510 ENOG4108Z0C Uvrb UvrC protein KS07_00515 ENOG41066A3 ATP guanido phosphotransferase KS07_00525 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) KS07_00530 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) KS07_00535 ENOG4105CTP PilT protein domain protein KS07_00540 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) KS07_00545 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) KS07_00550 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) KS07_00560 ENOG4105D7W serine acetyltransferase KS07_00570 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) KS07_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 KS07_00580 ENOG4105M0M Tetracycline resistance protein KS07_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KS07_00605 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) KS07_00615 ENOG4108VZM 50s ribosomal protein L10 KS07_00620 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) KS07_00625 ENOG4107Y49 methyltransferase KS07_00630 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KS07_00635 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KS07_00640 ENOG4105XPM ribosomal protein KS07_00645 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) KS07_00650 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) KS07_00655 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) KS07_00660 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) KS07_00665 ENOG4107SKW Inherit from COG: Alpha beta hydrolase KS07_00670 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) KS07_00675 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) KS07_00680 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) KS07_00685 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) KS07_00690 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity KS07_00695 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) KS07_00700 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) KS07_00705 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) KS07_00710 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) KS07_00715 ENOG41082SA 50s ribosomal protein l29 KS07_00720 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal KS07_00735 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits KS07_00745 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) KS07_00750 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) KS07_00755 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) KS07_00760 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) KS07_00765 ENOG4105VPB 50S ribosomal protein L30 KS07_00770 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) KS07_00775 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KS07_00780 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KS07_00785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KS07_00795 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) KS07_00805 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits KS07_00810 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) KS07_00815 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KS07_00820 ENOG4108ZT0 50S ribosomal protein l17 KS07_00825 ENOG4108JJB ABC transporter KS07_00830 ENOG4108JJB ABC transporter KS07_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) KS07_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) KS07_00845 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) KS07_00850 ENOG4108UJD 30S ribosomal protein S9 KS07_00855 ENOG4108I0C methyltransferase KS07_00875 ENOG4105D1F ATP-binding protein KS07_00890 ENOG4108NMV polysaccharide deacetylase KS07_00915 ENOG4108JPW Aminotransferase KS07_00925 ENOG4105CPQ Dehydrogenase KS07_00930 ENOG4105CHH sulfate transporter KS07_00940 ENOG4108SA1 esterase KS07_00960 ENOG410874W AraC family transcriptional regulator KS07_00965 ENOG4105EHZ conserved protein UCP016719 KS07_00970 ENOG4105D17 glycoside hydrolase, family 3 domain protein KS07_00985 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate KS07_00995 ENOG4105EWC Purine nucleoside phosphorylase KS07_01025 ENOG4105EMN RNA polymerase sigma factor KS07_01035 ENOG4105C8B TIGR00159 family KS07_01040 ENOG4107U5W ybbr family KS07_01045 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) KS07_01075 ENOG4105BZU Histidine kinase KS07_01080 ENOG4105C19 ABC transporter KS07_01095 ENOG4106K80 KS07_01105 ENOG41067MG lrgb family KS07_01115 ENOG41061AU MarR family Transcriptional regulator KS07_01130 ENOG4105BZU Histidine kinase KS07_01135 ENOG4105WH1 Two component transcriptional regulator luxr family KS07_01140 ENOG4105CJ1 ABC, transporter KS07_01165 ENOG4106DDH Sporulation-specific SASP protein KS07_01180 ENOG4107QTZ amino acid KS07_01185 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) KS07_01200 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KS07_01205 ENOG4105CXY transporter KS07_01240 ENOG4107SCQ Iron-containing alcohol dehydrogenase KS07_01245 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KS07_01250 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KS07_01255 ENOG4107ZTW SNARE associated Golgi KS07_01270 ENOG4105C72 UPF0176 protein KS07_01280 ENOG4105CM2 brancheD-chain amino acid aminotransferase KS07_01285 ENOG4108IQI permease KS07_01290 ENOG4108J5H Homocysteine s-methyltransferase KS07_01300 ENOG4105CSV Glutaminase KS07_01330 ENOG41076HS cation diffusion facilitator family transporter KS07_01335 ENOG4108TVJ Nitroreductase KS07_01340 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase KS07_01345 ENOG4108VGI doxx family KS07_01350 ENOG4105XXY Thioredoxin KS07_01365 ENOG4105DGI Alkaline phosphatase KS07_01370 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KS07_01375 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KS07_01380 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) KS07_01385 ENOG4107EPV Aminotransferase class V KS07_01390 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS07_01395 ENOG4105J7D transcriptional regulator KS07_01405 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold KS07_01410 ENOG41060AI SEC-C motif KS07_01415 ENOG4107SET aldo keto reductase KS07_01445 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KS07_01455 ENOG4105DSE periplasmic solute binding protein KS07_01460 ENOG4105DIK (ABC) transporter KS07_01470 ENOG4105DEN Luciferase family KS07_01475 ENOG4108N0M stress protein KS07_01480 ENOG4106FN3 tellurium resistance protein KS07_01485 ENOG4106FN3 tellurium resistance protein KS07_01490 ENOG4107TS3 membrane protein, TerC KS07_01495 ENOG4108TTB tellurium resistance protein KS07_01505 ENOG41079KZ Major Facilitator Superfamily KS07_01510 ENOG4108IJ7 Glycine betaine KS07_01515 ENOG4107SQ8 Glycine betaine KS07_01545 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KS07_01575 ENOG4105EIG urea carboxylase-associated protein 1 KS07_01580 ENOG4107RA1 nh(3)-dependent nad( ) synthetase KS07_01590 ENOG4105I1F Resistance protein KS07_01595 ENOG4108WBH protein TIM barrel KS07_01600 ENOG4105DJB Major Facilitator Superfamily KS07_01605 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KS07_01610 ENOG4105I82 acetyl xylan esterase KS07_01615 ENOG410756H nucleotidyltransferase KS07_01625 ENOG4105C26 Dehydrogenase KS07_01630 ENOG4105CK7 Sodium proline symporter KS07_01635 ENOG4107YHD transcriptional regulator KS07_01640 ENOG4105CAY ferredoxin--nadp reductase KS07_01645 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KS07_01650 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit KS07_01655 ENOG4108IFG nitrite reductase, (NAD(P)H) KS07_01660 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) KS07_01675 ENOG4105CKI cobalamin synthesis protein KS07_01680 ENOG4105E2A Dehydrogenase KS07_01685 ENOG4105HHM rdd domain containing protein KS07_01705 ENOG41080HJ 6-phospho 3-hexuloisomerase KS07_01710 ENOG4108VA3 3-hexulose-6-phosphate synthase KS07_01715 ENOG4105KVH Transcriptional regulator KS07_01745 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) KS07_01760 ENOG4105CDA abc transporter atp-binding protein KS07_01765 ENOG4105DRP amino acid AbC transporter KS07_01775 ENOG4106P55 Transcriptional regulator KS07_01780 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase KS07_01785 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) KS07_01790 ENOG41069ZX KS07_01795 ENOG41069ZX KS07_01800 ENOG4105DUX Transporter KS07_01815 ENOG4105E1K spore germination protein KS07_01830 ENOG4105CPU Monooxygenase KS07_01835 ENOG4108XSB acetyltransferase, (GNAT) family KS07_01840 ENOG4105EAB amino acid AbC transporter KS07_01845 ENOG4108HW4 amino acid AbC transporter KS07_01855 ENOG4105CH2 amidohydrolase KS07_01860 ENOG4108PGP mmge prpd family protein KS07_01870 ENOG4107WD8 ABC transporter, permease KS07_01875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS07_01880 ENOG4105BZU Histidine kinase KS07_01900 ENOG4105CFH Aspartokinase KS07_01905 ENOG4105DHS permease protein KS07_01910 ENOG4105CM4 permease protein KS07_01915 ENOG4108IPW abc transporter atp-binding protein KS07_01930 ENOG4105R8C Transcriptional regulator KS07_01935 ENOG4108DBC nitroreductase KS07_01940 ENOG41067V3 Antibiotic biosynthesis monooxygenase KS07_01945 ENOG4105YVS arsR family transcriptional regulator KS07_01955 ENOG4108JPW Aminotransferase KS07_01960 ENOG4105C26 Dehydrogenase KS07_01970 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KS07_01975 ENOG4105KTB nuclear export factor GLE1 KS07_01980 ENOG4108T5E Copper resistance protein KS07_01985 ENOG4108ZYE Transcriptional regulator KS07_02005 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase KS07_02025 ENOG4105E7W lamb ycsf family protein KS07_02030 ENOG4105C5A transporter KS07_02035 ENOG4105CFM UPF0317 protein KS07_02040 ENOG4105P4J Allophanate hydrolase, subunit 1 KS07_02050 ENOG4107258 Transcriptional regulator KS07_02055 ENOG4105XJB lipolytic protein G-D-S-L family KS07_02065 ENOG41061CK Antibiotic biosynthesis monooxygenase KS07_02070 ENOG4107RVG penicillin-binding protein KS07_02075 ENOG4107QM2 Aldo Keto reductase KS07_02080 ENOG4105ETD TRANSCRIPTIONal KS07_02090 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KS07_02105 ENOG410606W general stress protein KS07_02115 ENOG4105VCH membrane KS07_02125 ENOG4105C9U ATP-dependent DNA helicase RecQ KS07_02140 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) KS07_02145 ENOG4107R8N Glycosyl transferase, family 2 KS07_02155 ENOG4105C0X amino acid KS07_02200 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) KS07_02210 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) KS07_02215 ENOG4105RXJ KS07_02220 ENOG4105KPY Small multidrug resistance protein KS07_02225 ENOG4105EU9 KS07_02230 ENOG4105QVS general stress protein KS07_02235 ENOG41082W1 Cupin 2, conserved barrel domain protein KS07_02250 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit KS07_02255 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism KS07_02260 ENOG4108MRH transcriptional regulatory protein KS07_02265 ENOG4107QJT sodium dicarboxylate symporter KS07_02270 ENOG4106F5Q Membrane KS07_02275 ENOG4105CJ1 ABC, transporter KS07_02290 ENOG4105FDT acyl-CoA dehydrogenase KS07_02310 ENOG4105SZ6 Thioredoxin KS07_02315 ENOG4105CPF Cell wall formation (By similarity) KS07_02320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) KS07_02325 ENOG4105C1J atp-dependent rna helicase KS07_02330 ENOG410905X membrane-flanked domain protein KS07_02335 ENOG4105CKV Membrane KS07_02345 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) KS07_02350 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein KS07_02355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KS07_02365 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) KS07_02370 ENOG4107MMM Anti-sigma-factor antagonist KS07_02375 ENOG4105FUA antagonist KS07_02380 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase KS07_02385 ENOG4107SGM protein serine threonine phosphatase KS07_02390 ENOG4105WN5 stage II sporulation protein KS07_02395 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KS07_02405 ENOG41064BQ Phosphatase KS07_02420 ENOG410906U SprT-like KS07_02465 ENOG4106ANW SMI1_KNR4 KS07_02480 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KS07_02495 ENOG4105CSH Transporter KS07_02510 ENOG4108ZMQ domain protein KS07_02520 ENOG4108Z40 Transcriptional regulator KS07_02525 ENOG4108RYK Nad-dependent epimerase dehydratase KS07_02530 ENOG4105ECK Fatty Acid Desaturase KS07_02535 ENOG4105VEQ Cold shock protein KS07_02540 ENOG4108VJ1 Transcriptional regulator (CarD family KS07_02545 ENOG4105XTG Pfam:DUF156 KS07_02550 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase KS07_02555 ENOG4105C72 UPF0176 protein KS07_02560 ENOG4105VFE sira family KS07_02565 ENOG4107TPS domain protein KS07_02570 ENOG4105VFE sira family KS07_02575 ENOG41087NI Sulfite exporter TauE/SafE KS07_02595 ENOG4105IRW patatin-like phospholipase family protein KS07_02605 ENOG41082W1 Cupin 2, conserved barrel domain protein KS07_02620 ENOG4105DNP FAD linked oxidase domain protein KS07_02625 ENOG4105PGM cation diffusion facilitator family transporter KS07_02630 ENOG4105H3G oxidoreductase KS07_02640 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein KS07_02655 ENOG4105DQ4 alcohol dehydrogenase KS07_02660 ENOG4105VUF Transcriptional regulator KS07_02670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KS07_02680 ENOG4105EQ0 Major Facilitator superfamily KS07_02685 ENOG4108JGH Tetr family transcriptional regulator KS07_02700 ENOG4105E2A Dehydrogenase KS07_02705 ENOG4105PGS Spore coat protein KS07_02720 ENOG4105ENE Histidine kinase KS07_02725 ENOG4108VB1 regulatoR KS07_02730 ENOG4105EYF MMPL domain protein KS07_02750 ENOG4108JYZ YitT family KS07_02760 ENOG4105C2C drug resistance transporter, Bcr CflA KS07_02765 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KS07_02790 ENOG4105F2W methyltransferase KS07_02795 ENOG4105DRR Transcriptional regulator, GntR family KS07_02815 ENOG4105FQP Beta-lactamase KS07_02820 ENOG41090UD (LipO)protein KS07_02825 ENOG4108SUT Major Facilitator Superfamily KS07_02830 ENOG4108TZY GntR Family Transcriptional Regulator KS07_02835 ENOG4105JXH GntR family transcriptional regulator KS07_02840 ENOG4105DJ2 Major Facilitator Superfamily KS07_02860 ENOG4107QTZ amino acid KS07_02880 ENOG4107QNK )-transporter KS07_02920 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) KS07_02925 ENOG4105K8N protein family UPF0079, ATPase KS07_02930 ENOG41072GX Peptidase M22 Glycoprotease KS07_02935 ENOG410801F ribosomal-protein-alanine acetyltransferase KS07_02940 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KS07_02945 ENOG4105C5H ABC transporter KS07_02950 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KS07_02955 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) KS07_02960 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KS07_02965 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KS07_02975 ENOG4108TYN CAAX amino terminal protease family protein KS07_02980 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) KS07_02985 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) KS07_02995 ENOG4106BHF KS07_03015 ENOG4105DZR Type I site-specific deoxyribonuclease KS07_03020 ENOG4105PGZ NB-ARC domain KS07_03025 ENOG4105CPQ Dehydrogenase KS07_03030 ENOG4105CT4 transporter KS07_03045 ENOG41087YS Phage shock protein A KS07_03050 ENOG4105DQX Zinc finger domain KS07_03055 ENOG4108WV1 Pfam:DUF477 KS07_03065 ENOG4105EXC Acyl-transferase KS07_03070 ENOG4108P49 AntiSigma factor KS07_03075 ENOG4105JVQ RNA Polymerase KS07_03105 ENOG4107STQ Multicopper oxidase KS07_03110 ENOG4105C85 amino acid KS07_03115 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KS07_03130 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KS07_03145 ENOG4105C7N Xanthine uracil vitamin C permease KS07_03170 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) KS07_03175 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit KS07_03180 ENOG4105C83 adenylosuccinate lyase KS07_03185 ENOG4105C8V SAICAR synthetase KS07_03190 ENOG4105VR9 phosphoribosylformylglycinamidine synthase KS07_03195 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I KS07_03200 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii KS07_03210 ENOG4105CXB phosphoribosylaminoimidazole synthetase KS07_03215 ENOG4108V3E phosphoribosylglycinamide formyltransferase KS07_03220 ENOG4105DC1 bifunctional purine biosynthesis protein purh KS07_03225 ENOG4105C12 Phosphoribosylglycinamide synthetase KS07_03240 ENOG4108R5T secreted protein KS07_03245 ENOG4105KGF protein, YerC YecD KS07_03250 ENOG4105CBC glutamate synthase KS07_03265 ENOG4105C4R Atp-dependent dna helicase KS07_03270 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) KS07_03280 ENOG4105CRN Aminoglycoside phosphotransferase KS07_03285 ENOG4105KT7 mgtC SapB transporter KS07_03290 ENOG4105CK7 Sodium proline symporter KS07_03295 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KS07_03300 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KS07_03305 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KS07_03310 ENOG4108IG5 Transcriptional regulator KS07_03320 ENOG4105CBD Diacylglycerol kinase KS07_03325 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KS07_03330 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS07_03345 ENOG4105BZU Histidine kinase KS07_03350 ENOG4108MGH Enoyl-CoA hydratase KS07_03355 ENOG4108KQ6 Enoyl-CoA hydratase KS07_03360 ENOG41062T2 Acyl carrier protein KS07_03375 ENOG4105CJ1 ABC, transporter KS07_03390 ENOG4105C0W non-ribosomal peptide synthetase KS07_03435 ENOG4105C0W non-ribosomal peptide synthetase KS07_03445 ENOG4107QKG PfaD family KS07_03450 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KS07_03460 ENOG4105CDY transcriptional regulatory protein KS07_03470 ENOG41075D4 Aminoglycoside 6-adenylyltransferase KS07_03485 ENOG4105WEF catalase KS07_03490 ENOG4105M18 -acetyltransferase KS07_03500 ENOG4105H67 Protein of unknown function (DUF421) KS07_03505 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) KS07_03510 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KS07_03530 ENOG4106I4J membrane KS07_03535 ENOG41082F9 transcriptional regulator KS07_03540 ENOG41061H0 Monooxygenase KS07_03545 ENOG4108R1P KS07_03550 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KS07_03555 ENOG4105E0M Sulfatase KS07_03560 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase KS07_03570 ENOG41090R9 glycosyltransferase KS07_03575 ENOG4107R51 Glycosyl transferase, family 2 KS07_03580 ENOG41090R9 glycosyltransferase KS07_03585 ENOG4105EU0 Major facilitator Superfamily KS07_03590 ENOG4105CUB amino acid KS07_03595 ENOG4105C26 Dehydrogenase KS07_03600 ENOG4105FKZ Methyl-accepting chemotaxis KS07_03605 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KS07_03610 ENOG4107TVC Glycosyl transferase, family 2 KS07_03615 ENOG4105C5H ABC transporter KS07_03620 ENOG4107SWG transcriptional regulator MERR family KS07_03625 ENOG4105DXB Major Facilitator superfamily KS07_03630 ENOG4105C5H ABC transporter KS07_03635 ENOG4105FDU atp-dependent rna helicase KS07_03645 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein KS07_03660 ENOG4108J20 pectate lyase KS07_03665 ENOG4107QPK )-transporter KS07_03695 ENOG4108VAC response regulator KS07_03705 ENOG4108Z6X (sortase) family KS07_03715 ENOG4108MRH transcriptional regulatory protein KS07_03740 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) KS07_03745 ENOG4108RPX mosc domain containing protein KS07_03765 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) KS07_03805 ENOG4105C5Y PTS System KS07_03810 ENOG4105CG3 alpha amylase, catalytic region KS07_03815 ENOG4107414 GntR family transcriptional regulator KS07_03820 ENOG4108RCM Nitroreductase KS07_03835 ENOG4105CGH 5'-nucleotidase KS07_03840 ENOG4107RKG DJ-1/PfpI family KS07_03845 ENOG4105ETE Transcriptional regulator (LacI family KS07_03850 ENOG4105E2X shikimate dehydrogenase KS07_03855 ENOG4105FF2 Type I DHQase KS07_03870 ENOG4105KJF protein tyrosine phosphatase KS07_03880 ENOG4107U9T Pfam:Ribonuclease_BN KS07_03890 ENOG4108ISG Major Facilitator KS07_03895 ENOG4105UPD Calcium Proton KS07_03905 ENOG4105D8X mechanosensitive ion channel KS07_03940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS07_03950 ENOG4106KE4 Dehydrogenase KS07_03960 ENOG4105D7N magnesium and cobalt transport protein CorA KS07_03970 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KS07_03990 ENOG4107RUY (E1 component), alpha subunit KS07_04000 ENOG4107QKR Dehydrogenase KS07_04010 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family KS07_04020 ENOG4105F8D glycoside hydrolase family 4 KS07_04025 ENOG4108Q3X Transcriptional regulator KS07_04030 ENOG4105CI1 PTS System KS07_04040 ENOG4105BZ1 (ABC) transporter KS07_04045 ENOG4105BZ1 (ABC) transporter KS07_04055 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KS07_04060 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KS07_04065 ENOG4105U3E Transcriptional regulator KS07_04070 ENOG4105DYS nad(p)h dehydrogenase (quinone) KS07_04075 ENOG4105H93 Acyltransferase family KS07_04090 ENOG4108YYS metal-dependent hydrolase (By similarity) KS07_04095 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS07_04100 ENOG410834F Transcriptional regulator KS07_04110 ENOG4105JAB phenazine biosynthesis protein, phzf family KS07_04115 ENOG4107Y03 Nitroreductase KS07_04130 ENOG4105ECP epimerase KS07_04135 ENOG410902V Modulates RecA activity (By similarity) KS07_04145 ENOG4105F27 Major Facilitator KS07_04155 ENOG4108TCS Glutamyl endopeptidase KS07_04175 ENOG4106AKJ KS07_04180 ENOG4105D74 hydrolase KS07_04185 ENOG4105CKK Glycosyl transferase, family 2 KS07_04190 ENOG4105EJV Membrane KS07_04195 ENOG41067AE Membrane-bound metal-dependent hydrolase KS07_04200 ENOG4105CEN a g-specific adenine glycosylase KS07_04205 ENOG4106BXE KS07_04210 ENOG4105CAN Short-chain dehydrogenase reductase Sdr KS07_04230 ENOG4105BZ1 (ABC) transporter KS07_04235 ENOG4107NBY Membrane KS07_04240 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KS07_04245 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KS07_04250 ENOG4105G5W regulator Fur family KS07_04255 ENOG4105TUA UPF0295 protein KS07_04360 ENOG4107S6Z Na H antiporter KS07_04365 ENOG4105EC3 peptidase S51, dipeptidase E KS07_04370 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) KS07_04375 ENOG4105DNP FAD linked oxidase domain protein KS07_04385 ENOG4105DEF Extracellular solute-binding protein, family 5 KS07_04395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS07_04400 ENOG4105C3U ABC transporter KS07_04405 ENOG4108JQ7 (ABC) transporter KS07_04420 ENOG4105E2Y ABC, transporter KS07_04425 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein KS07_04430 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component KS07_04440 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) KS07_04445 ENOG4107D63 KS07_04450 ENOG4105VZ8 Transcriptional regulator KS07_04465 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) KS07_04475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) KS07_04495 ENOG4105CYN Serine protein kinase KS07_04505 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes KS07_04510 ENOG4105CW7 secretion protein, HlyD family KS07_04515 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS07_04520 ENOG4105CS1 NAD(P)H quinone oxidoreductase KS07_04535 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family KS07_04540 ENOG4105CZV ABC transporter KS07_04545 ENOG4105CJ1 ABC, transporter KS07_04550 ENOG4108TU7 Inherit from COG: (ABC) transporter KS07_04555 ENOG4105VEQ Cold shock protein KS07_04565 ENOG4105BZU Histidine kinase KS07_04605 ENOG4108YBP pseudouridine synthase KS07_04615 ENOG41080XP Cbs domain KS07_04620 ENOG4107YBY Hydrolase KS07_04625 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KS07_04630 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KS07_04635 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator KS07_04645 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) KS07_04650 ENOG4105C6V Glycerol-3-phosphate dehydrogenase KS07_04660 ENOG4105BZU Histidine kinase KS07_04665 ENOG4105WH1 Two component transcriptional regulator luxr family KS07_04700 ENOG4105ED1 spovr family KS07_04705 ENOG4105G6Z alkaline phosphatase KS07_04720 ENOG4105BZN citrate synthase KS07_04725 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KS07_04730 ENOG4105CUB amino acid KS07_04735 ENOG4105C8J )-transporter KS07_04745 ENOG4105J37 KS07_04750 ENOG4108AEY RNA polymerase sigma factor KS07_04755 ENOG4105F6E Acyl-transferase KS07_04760 ENOG4105C37 (CBS) domain KS07_04770 ENOG4105CHM Aminotransferase KS07_04775 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase KS07_04780 ENOG4105C37 (CBS) domain KS07_04790 ENOG4105WMR Protein CrcB homolog KS07_04795 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KS07_04805 ENOG4105D64 Mechanosensitive ion channel KS07_04810 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) KS07_04815 ENOG4107VMI polysaccharide deacetylase KS07_04820 ENOG4105F0I Aminotransferase KS07_04825 ENOG4105W1N transcriptional regulator KS07_04830 ENOG4105IIP Membrane KS07_04840 ENOG4105BZ1 (ABC) transporter KS07_04845 ENOG4105BZ1 (ABC) transporter KS07_04865 ENOG410839P KS07_04875 ENOG4106MP8 UPF0754 membrane protein KS07_04880 ENOG4105WZB UPF0342 protein KS07_04885 ENOG4105F1N DNA alkylation repair KS07_04895 ENOG4105D4P Coproporphyrinogen iii oxidase KS07_04905 ENOG4107S91 Sodium hydrogen exchanger KS07_04910 ENOG4105NCW Trka-c domain protein KS07_04920 ENOG4105CGU Enoyl-CoA hydratase KS07_04930 ENOG4108IUX (ABC) transporter KS07_04935 ENOG4105RHA ABC transporter, permease KS07_04940 ENOG4107VRP DNA repair exonuclease KS07_04945 ENOG4106D4I domain protein KS07_04950 ENOG4105EQI Metal Dependent Phosphohydrolase KS07_04960 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KS07_05005 ENOG4105NBU tryptophan transport protein KS07_05010 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) KS07_05015 ENOG4105K59 histidine triad (HIT) protein KS07_05045 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation KS07_05050 ENOG4105BZ4 penicillin-binding protein KS07_05055 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) KS07_05060 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) KS07_05065 ENOG4105C1Q protoporphyrinogen oxidase KS07_05075 ENOG4105ECB domain protein KS07_05090 ENOG4105DER m42 family KS07_05100 ENOG4106AXD KS07_05105 ENOG4108RQ5 Beta-lactamase domain-containing protein KS07_05110 ENOG4105DF9 Lipoate-protein, ligase KS07_05120 ENOG4105CEY Amp-dependent synthetase and ligase KS07_05130 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 KS07_05145 ENOG4108HUF Transporter KS07_05150 ENOG4107TB6 phosphoglycerate mutase KS07_05160 ENOG4107F3J Amp-dependent synthetase and ligase KS07_05165 ENOG4107ZYJ bioY protein KS07_05170 ENOG4106YBV Methyl-accepting chemotaxis KS07_05190 ENOG4105XVF Competence transcription factor KS07_05200 ENOG4108ZMX Domain of unknown function (DU1801) KS07_05215 ENOG4105X3H Excalibur domain protein KS07_05220 ENOG4105K8R UPF0145 protein KS07_05225 ENOG4105E1V na solute symporter KS07_05230 ENOG4106CAD Protein of unknown function (DUF3311) KS07_05235 ENOG41060YP KS07_05250 ENOG4107SCK Monooxygenase KS07_05255 ENOG4108INS Transcriptional regulator KS07_05260 ENOG4108KK1 membrane protein AbrB duplication KS07_05270 ENOG4108IG5 Transcriptional regulator KS07_05280 ENOG4108QY0 Membrane KS07_05285 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination KS07_05290 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation KS07_05300 ENOG4105EYH Exonuclease KS07_05345 ENOG4105ERH Fumarylacetoacetate hydrolase KS07_05365 ENOG4105CAQ asparagine synthetase KS07_05375 ENOG4105UQX Mate efflux family protein KS07_05380 ENOG4106HBX Transcriptional Regulator AraC Family KS07_05385 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KS07_05390 ENOG4105SF0 DinB family KS07_05395 ENOG4108ZUB Lysine exporter protein (Lyse ygga) KS07_05400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KS07_05405 ENOG4105MYW Pentapeptide repeat protein KS07_05410 ENOG4105MA6 gCN5-related N-acetyltransferase KS07_05420 ENOG4108VPT UPF0234 protein KS07_05425 ENOG4105QNR S1 RNA binding domain protein KS07_05430 ENOG4105DIH basic membrane KS07_05435 ENOG4105C8Q Methyl-accepting chemotaxis KS07_05440 ENOG4107E6A Cytochrome p-450 KS07_05445 ENOG4105EPR degv family KS07_05450 ENOG4107AYK membrAne KS07_05460 ENOG41073B9 KS07_05470 ENOG4108KP7 hydrolase KS07_05475 ENOG4108MXZ Esterase KS07_05480 ENOG4105VG1 fes assembly suf system protein KS07_05485 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) KS07_05490 ENOG4105IQ5 FAD linked oxidase domain protein KS07_05500 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase KS07_05510 ENOG4105CAS nag kinase KS07_05515 ENOG4105C8Y Acetylornithine aminotransferase KS07_05520 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KS07_05530 ENOG4105DBV ornithine carbamoyltransferase KS07_05560 ENOG4107RMD Basic membrane lipoprotein KS07_05575 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KS07_05580 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KS07_05590 ENOG4105C3U ABC transporter KS07_05595 ENOG4108JQ7 (ABC) transporter KS07_05610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS07_05620 ENOG4105C31 Tryptophanyl-tRNA synthetase KS07_05630 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KS07_05635 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS07_05645 ENOG4108JQ7 (ABC) transporter KS07_05660 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) KS07_05665 ENOG4108ZCF integral membrane protein KS07_05670 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis KS07_05680 ENOG4105DPN Oligoendopeptidase f KS07_05695 ENOG4105T58 Dithiol-disulfide isomerase KS07_05700 ENOG4108Z18 K06886 hemoglobin KS07_05705 ENOG4105E4C Lytic transglycosylase catalytic KS07_05710 ENOG4105MIX Adenylate cyclase KS07_05725 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KS07_05730 ENOG4105EMS pseudouridine synthase KS07_05735 ENOG4107S1Q Phosphatase KS07_05745 ENOG4105ETU transcriptional activator (TenA KS07_05750 ENOG4108VEU Thiamine monophosphate synthase KS07_05770 ENOG4105D06 uba thif-type nad fad binding protein KS07_05775 ENOG4105DWF phosphomethylpyrimidine kinase KS07_05780 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH KS07_05785 ENOG4107A88 KS07_05840 ENOG4105ENA helicase KS07_05860 ENOG4108ZMI UPF0477 protein KS07_05870 ENOG4105C28 cystathionine KS07_05875 ENOG4105C28 cystathionine KS07_05905 ENOG4106BHF KS07_05920 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase KS07_05935 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS07_05950 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase KS07_05955 ENOG4105CMR udp-glucose 4-epimerase KS07_05960 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) KS07_05965 ENOG4105CK1 PTS System KS07_05970 ENOG4105VCP PTS System KS07_06000 ENOG4105KT7 mgtC SapB transporter KS07_06025 ENOG4108IEG Formate dehydrogenase Alpha subunit KS07_06035 ENOG4106A3M Cytochrome p-450 KS07_06040 ENOG41087PP glycosyltransferase MGT family KS07_06050 ENOG4105EXQ uroporphyrinogen iii synthase hem4 KS07_06055 ENOG4105C4B ABC transporter, permease KS07_06060 ENOG4108IXI (ABC) transporter KS07_06070 ENOG4105Q95 Cupin 2, conserved barrel domain protein KS07_06085 ENOG4105D2H Uronic isomerase KS07_06090 ENOG4105CT4 transporter KS07_06095 ENOG4107KJX Transcriptional regulator KS07_06100 ENOG4107QZW Altronate oxidoreductase KS07_06105 ENOG4105CTX dehydratase KS07_06110 ENOG4107TSN permease KS07_06130 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KS07_06135 ENOG4105KWG Pfam:DUF1696 KS07_06140 ENOG4105K7W phage-related replication protein KS07_06145 ENOG410635T phage-like element pbsx protein KS07_06225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KS07_06240 ENOG4105CJ3 phosphate transporter KS07_06245 ENOG4107GRR phosphate transport regulator KS07_06250 ENOG4107R7I amino acid KS07_06260 ENOG4105EDW glycosyl transferase, family 39 KS07_06265 ENOG4105CKK Glycosyl transferase, family 2 KS07_06270 ENOG4105C0H protease KS07_06280 ENOG4108ME1 Peptidase M55 D-aminopeptidase KS07_06285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KS07_06290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KS07_06295 ENOG4105C3U ABC transporter KS07_06305 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A KS07_06310 ENOG4105DTQ mandelate racemase muconate lactonizing KS07_06315 ENOG4107SN7 NLP P60 protein KS07_06320 ENOG4108JQ7 (ABC) transporter KS07_06325 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) KS07_06330 ENOG4107TUM Amidinotransferase KS07_06335 ENOG4108S4H thioesterase Superfamily protein KS07_06340 ENOG4108428 Inherit from COG: -acetyltransferase KS07_06350 ENOG41080TC multidrug resistance protein KS07_06355 ENOG4105CIY formyltetrahydrofolate deformylase KS07_06360 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KS07_06375 ENOG4105K56 Transcriptional regulator KS07_06380 ENOG4108ZHJ Organic hydroperoxide resistance protein KS07_06395 ENOG4107TVC Glycosyl transferase, family 2 KS07_06405 ENOG4105D8G Major Facilitator superfamily KS07_06410 ENOG4108Y4K DNA-binding transcriptional activator KS07_06415 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) KS07_06420 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KS07_06430 ENOG4108W7F transporter, permease KS07_06435 ENOG4108JJB ABC transporter KS07_06440 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein KS07_06445 ENOG4105VRS hydrolase family 18 KS07_06460 ENOG4105CJW magnesium transporter KS07_06465 ENOG4105V75 Transcriptional regulator KS07_06490 ENOG4105DQE DNA ligase KS07_06495 ENOG4105FDF Could be involved in DNA repair (By similarity) KS07_06505 ENOG4107T5V SNARE associated Golgi KS07_06510 ENOG4107TS3 membrane protein, TerC KS07_06515 ENOG4108WZW RNA polymerase sigma KS07_06525 ENOG410681C small acid-soluble spore protein KS07_06535 ENOG4105D0M Protease HtpX homolog KS07_06560 ENOG4108TGC Acyltransferase KS07_06565 ENOG4105BZU Histidine kinase KS07_06570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KS07_06575 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) KS07_06585 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KS07_06595 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate KS07_06600 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) KS07_06605 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) KS07_06610 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) KS07_06620 ENOG4105BZU Histidine kinase KS07_06625 ENOG41090MY MarR family Transcriptional regulator KS07_06630 ENOG4105ER2 Ompa motb domain protein KS07_06635 ENOG4105E14 MotA TolQ exbB proton channel KS07_06650 ENOG4108K88 Membrane KS07_06660 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) KS07_06665 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase KS07_06670 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) KS07_06675 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) KS07_06690 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr KS07_06710 ENOG4105F0V Cell wall hydrolase KS07_06725 ENOG4105C59 p-type ATPase KS07_06730 ENOG4105DC7 peptidase M24 KS07_06745 ENOG4105CID antiterminator KS07_06755 ENOG4105KRI phosphocarrier protein (HPr KS07_06760 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KS07_06770 ENOG4105F6S Spore photoproduct lyase KS07_06775 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer KS07_06780 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KS07_06785 ENOG4105K4I Scp-like extracellular KS07_06795 ENOG4105BZU Histidine kinase KS07_06800 ENOG4105CHM Aminotransferase KS07_06810 ENOG4107R88 Chemotaxis protein (CheV) KS07_06815 ENOG4105UIN KS07_06825 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein KS07_06835 ENOG4105K6S Short-chain dehydrogenase reductase Sdr KS07_06845 ENOG4105EPM Diguanylate phosphodiesterase KS07_06850 ENOG4107IN1 Protein of unknown function (DUF1797) KS07_06855 ENOG4108XRC Protein of unknown function (DUF458) KS07_06885 ENOG4105NQC Flavodoxin KS07_06905 ENOG4105D8X mechanosensitive ion channel KS07_06910 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KS07_06925 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) KS07_06930 ENOG4105D06 uba thif-type nad fad binding protein KS07_06935 ENOG4105CVM Molybdenum cofactor synthesis domain protein KS07_06940 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein KS07_06945 ENOG4108ZAF Molybdopterin KS07_06950 ENOG41067WU Molybdopterin converting factor (Subunit 1) KS07_06960 ENOG4107X8C Efflux transporter RND family MFP subunit KS07_06965 ENOG4105C19 ABC transporter KS07_06970 ENOG4107RBB ABC transporter, permease KS07_06975 ENOG4105E98 transcriptional regulator DeoR family KS07_06980 ENOG4105DE4 1-phosphofructokinase KS07_06985 ENOG4105DM4 PTS System KS07_07000 ENOG4105C5H ABC transporter KS07_07005 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) KS07_07030 ENOG4105BZU Histidine kinase KS07_07040 ENOG4107ZYR domain protein KS07_07045 ENOG4105CPN adenine deaminase KS07_07050 ENOG4105CN5 Metallo-Beta-Lactamase KS07_07055 ENOG4106148 UPF0356 protein KS07_07060 ENOG4108X4Q Hydrolase KS07_07065 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KS07_07085 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KS07_07090 ENOG4105C0W non-ribosomal peptide synthetase KS07_07095 ENOG4107SQU synthase KS07_07100 ENOG4105C0W non-ribosomal peptide synthetase KS07_07105 ENOG4107SQU synthase KS07_07110 ENOG4107SQU synthase KS07_07115 ENOG4107SQU synthase KS07_07120 ENOG4105C0W non-ribosomal peptide synthetase KS07_07125 ENOG4105FQP Beta-lactamase KS07_07135 ENOG4105CPP Dehydrogenase, E1 component KS07_07140 ENOG4105C7S Dehydrogenase KS07_07145 ENOG4107QN2 dihydrolipoyl dehydrogenase KS07_07160 ENOG4105CXN decarboxylase KS07_07165 ENOG4105WBI UPF0223 protein KS07_07180 ENOG4105ECY inositol monophosphatase KS07_07190 ENOG4105D4Y metalloprotease KS07_07210 ENOG4105CI3 gtp-binding protein typa KS07_07215 ENOG4105QA2 KS07_07230 ENOG4108IAB Phoh family KS07_07240 ENOG4105CSV Glutaminase KS07_07250 ENOG4105CNI cell division protein FtsW KS07_07255 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) KS07_07265 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KS07_07275 ENOG4105BZ9 Cytochrome C oxidase, subunit I KS07_07280 ENOG4105CCU oxidase (Subunit III) KS07_07285 ENOG41064X9 cytochrome C oxidase subunit IV KS07_07300 ENOG41080XQ Signal transduction protein with cbs domains KS07_07305 ENOG4106UY4 Inherit from COG: Scp-like extracellular KS07_07330 ENOG4106H78 methyltransferase KS07_07335 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) KS07_07340 ENOG4105H20 Sporulation integral membrane protein YlbJ KS07_07345 ENOG4105D78 K07001 NTE family protein KS07_07350 ENOG41063PX domain protein KS07_07355 ENOG4105CDE UPF0348 protein KS07_07360 ENOG4105KNH Nucleic acid-binding protein KS07_07365 ENOG41067VY 50S ribosomal protein L32 KS07_07390 ENOG4108V6E Cell division protein mraZ KS07_07395 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) KS07_07405 ENOG4105CJN penicillin-binding protein KS07_07410 ENOG4105CJN penicillin-binding protein KS07_07415 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KS07_07420 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) KS07_07425 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) KS07_07430 ENOG4105CNI cell division protein FtsW KS07_07435 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KS07_07440 ENOG4105D4A Cell wall formation (By similarity) KS07_07445 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) KS07_07455 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) KS07_07460 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) KS07_07470 ENOG4105FFI sigma-e processing peptidase spoiiga KS07_07475 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS07_07485 ENOG4105DKW ABC transporter KS07_07495 ENOG4105WR5 sporulation protein, YlmC YmxH family KS07_07500 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase KS07_07505 ENOG4105DFA alanine racemase domain protein KS07_07510 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) KS07_07515 ENOG41067XK integral membrane protein KS07_07520 ENOG4105DBK s4 domain protein KS07_07535 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KS07_07545 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) KS07_07550 ENOG4105C34 Pseudouridine synthase KS07_07555 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) KS07_07565 ENOG4105CXT aspartate transcarbamylase KS07_07575 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KS07_07580 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain KS07_07585 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) KS07_07590 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) KS07_07595 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) KS07_07600 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) KS07_07620 ENOG4107RIQ Sulfate adenylate transferase KS07_07630 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KS07_07635 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein KS07_07640 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein KS07_07650 ENOG4105F23 Fibronectin-binding protein KS07_07660 ENOG4105DSJ YicC domain protein KS07_07665 ENOG4105KC4 UPF0296 protein KS07_07670 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) KS07_07680 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase KS07_07685 ENOG4105C25 Primosomal protein n' KS07_07690 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KS07_07695 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) KS07_07700 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B KS07_07705 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KS07_07710 ENOG4108ZF3 Phosphatase KS07_07715 ENOG4105D9P serine threonine protein kinase KS07_07720 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) KS07_07725 ENOG4105DJV ribulose-phosphate 3-epimerase KS07_07730 ENOG4105FJ0 thiamine KS07_07740 ENOG4105VB9 50S ribosomal protein l28 KS07_07745 ENOG4108ZAA Alkaline-shock protein KS07_07750 ENOG4105DP4 dak2 domain fusion protein ylov KS07_07760 ENOG4105EJQ L-serine dehydratase KS07_07765 ENOG4105CB5 ATP-dependent DNA helicase recG KS07_07770 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) KS07_07775 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) KS07_07780 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KS07_07785 ENOG4105CHR reductase KS07_07790 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) KS07_07795 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) KS07_07800 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) KS07_07805 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KS07_07815 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) KS07_07825 ENOG4105K5M 30s ribosomal protein S16 KS07_07830 ENOG4108BW8 UPF0109 protein KS07_07845 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) KS07_07850 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) KS07_07855 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) KS07_07860 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KS07_07870 ENOG4105VM1 flagellar KS07_07875 ENOG4105CMV Succinyl-CoA synthetase subunit beta KS07_07880 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha KS07_07885 ENOG4105C79 DNA protecting protein DprA KS07_07890 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) KS07_07895 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) KS07_07900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KS07_07905 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) KS07_07910 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) KS07_07920 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) KS07_07925 ENOG4108ZC9 flagellar basal-body rod protein flgc KS07_07930 ENOG4105VQ0 flagellar hook-basal body complex protein fliE KS07_07935 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) KS07_07940 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KS07_07955 ENOG4106YF4 Flagellar biosynthesis chaperone KS07_07965 ENOG410696Y Flagellar hook-length control protein KS07_07970 ENOG410822I Flagellar hook capping protein KS07_07975 ENOG4108JQA flagellar KS07_07980 ENOG41068WV flagellar FlbD family protein KS07_07990 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KS07_07995 ENOG4105DD5 Flagellar motor switch protein KS07_08000 ENOG4107YTP response regulator receiver protein KS07_08010 ENOG4105CN7 Flagellar biosynthetic protein FliP KS07_08015 ENOG4105VS8 Flagellar biosynthetic protein fliq KS07_08020 ENOG4105D19 Role in flagellar biosynthesis (By similarity) KS07_08025 ENOG4105D00 flagellar biosynthetic protein flhB KS07_08030 ENOG4105D7B Flagellar biosynthesis protein flha KS07_08035 ENOG4105FZW flagellar biosynthesis regulator FlhF KS07_08045 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) KS07_08050 ENOG4105CBS Chea signal transduction histidine kinase KS07_08055 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis KS07_08065 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) KS07_08070 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS07_08080 ENOG4105CE9 30S ribosomal protein S2 KS07_08090 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) KS07_08095 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) KS07_08100 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) KS07_08105 ENOG4105KNE Phosphatidate cytidylyltransferase KS07_08115 ENOG4105DZP Membrane-associated zinc metalloprotease KS07_08120 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) KS07_08125 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) KS07_08130 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) KS07_08135 ENOG4105CHV Transcription elongation factor NusA KS07_08140 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination KS07_08145 ENOG4105VHM ribosomal protein KS07_08150 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) KS07_08155 ENOG4105W7A Protein of unknown function (DUF503) KS07_08160 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) KS07_08165 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) KS07_08170 ENOG4105DTN riboflavin biosynthesis protein ribF KS07_08175 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) KS07_08180 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) KS07_08190 ENOG4105C1V Peptidase, M16 KS07_08205 ENOG4108S0H Dipicolinic acid synthetase, b subunit KS07_08210 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) KS07_08220 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KS07_08230 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit KS07_08240 ENOG4105CNU cell division protein FtsK KS07_08245 ENOG4105FDP GntR family transcriptional regulator KS07_08260 ENOG4105EYF MMPL domain protein KS07_08275 ENOG4108RKS Short-chain dehydrogenase reductase Sdr KS07_08280 ENOG4105XZV Protein of unknown function (DUF3243) KS07_08295 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase KS07_08300 ENOG4105CEV competence damage-inducible protein KS07_08305 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) KS07_08310 ENOG4108A04 Beta-lactamase KS07_08320 ENOG4105D48 metallophosphoesterase KS07_08325 ENOG4105MCT stage V sporulation protein S KS07_08330 ENOG4105CPQ Dehydrogenase KS07_08335 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KS07_08340 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KS07_08360 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) KS07_08370 ENOG4108151 Beta-lactamase domain protein KS07_08375 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KS07_08380 ENOG4108JA1 polyketide synthase KS07_08385 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KS07_08390 ENOG41062T2 Acyl carrier protein KS07_08395 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KS07_08400 ENOG4108MGH Enoyl-CoA hydratase KS07_08405 ENOG4108KQ6 Enoyl-CoA hydratase KS07_08410 ENOG4105C0W non-ribosomal peptide synthetase KS07_08415 ENOG4107SQU synthase KS07_08425 ENOG4105C0W non-ribosomal peptide synthetase KS07_08435 ENOG4106A3M Cytochrome p-450 KS07_08440 ENOG4105WFK nuclease KS07_08445 ENOG4105XPP Protein of unknown function (DUF1275) KS07_08455 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KS07_08465 ENOG4105K7W phage-related replication protein KS07_08470 ENOG4108X3M OsmC Ohr family protein KS07_08495 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) KS07_08520 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KS07_08525 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KS07_08530 ENOG4105U6W MutT NUDIX family protein KS07_08535 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KS07_08545 ENOG4106F1P AAA ATPase, central domain protein KS07_08550 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) KS07_08555 ENOG4105CXI aluminum resistance protein KS07_08560 ENOG4105KV4 Transcriptional regulator KS07_08565 ENOG4105C5F glutamine synthetase KS07_08585 ENOG41064BW Protein of unknown function (DUF2568) KS07_08600 ENOG4105CT4 transporter KS07_08605 ENOG4105DSG hydrolase family 43 KS07_08615 ENOG4105C93 Xylose Isomerase KS07_08620 ENOG4105CMG Carbohydrate kinase KS07_08625 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) KS07_08645 ENOG4105DQ4 alcohol dehydrogenase KS07_08700 ENOG4108M1A Chitin-binding protein KS07_08725 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KS07_08730 ENOG4105K7W phage-related replication protein KS07_08750 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) KS07_08760 ENOG4108SVB resolvase KS07_08765 ENOG4105VPS UPF0291 protein KS07_08770 ENOG4105CV1 Transketolase (EC 2.2.1.1) KS07_08780 ENOG4105VXM UPF0154 protein KS07_08790 ENOG4107QIV Cytochrome c biogenesis protein KS07_08825 ENOG4108I0Z Aconitate hydratase KS07_08830 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KS07_08845 ENOG41067CD Small, acid-soluble spore protein Tlp KS07_08855 ENOG4105MI2 KS07_08860 ENOG4105W8X HesB YadR YfhF-family protein KS07_08865 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) KS07_08870 ENOG4105K4P CoA-binding domain protein KS07_08875 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KS07_08905 ENOG4105CPQ Dehydrogenase KS07_08910 ENOG4108UHU Aldolase KS07_08915 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) KS07_08920 ENOG4105DMW Dehydrogenase reductase KS07_08930 ENOG4108I5G Major Facilitator superfamily KS07_08945 ENOG4105FVX KS07_08980 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS07_08990 ENOG4107SYN Glycosyl hydrolases family 43 KS07_09015 ENOG4105DTD Dehydrogenase KS07_09020 ENOG4108IIH CoA-transferase subunit B KS07_09025 ENOG4105D6N CoA-transferase, subunit a KS07_09030 ENOG4105CY2 Citrate transporter KS07_09035 ENOG4106A3M Cytochrome p-450 KS07_09040 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) KS07_09045 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) KS07_09050 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KS07_09055 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KS07_09060 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) KS07_09070 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KS07_09075 ENOG4107T5V SNARE associated Golgi KS07_09080 ENOG4107QX3 carboxylase KS07_09085 ENOG4105E39 Enoyl-CoA hydratase KS07_09090 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase KS07_09095 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit KS07_09100 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KS07_09105 ENOG4105CEY Amp-dependent synthetase and ligase KS07_09110 ENOG4105C1G acyl-Coa dehydrogenase KS07_09115 ENOG4105F32 YngK protein KS07_09120 ENOG4106U2H Protein of unknown function (DUF1360) KS07_09130 ENOG4105CEY Amp-dependent synthetase and ligase KS07_09135 ENOG4105C0W non-ribosomal peptide synthetase KS07_09145 ENOG4105C0W non-ribosomal peptide synthetase KS07_09150 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family KS07_09155 ENOG4108N2V aldose 1-epimerase KS07_09160 ENOG4107QJQ Mate efflux family protein KS07_09185 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KS07_09190 ENOG4108RWP Major Facilitator Superfamily protein KS07_09195 ENOG4105WAB arsR family transcriptional regulator KS07_09205 ENOG4108KSA LysR family transcriptional regulator KS07_09210 ENOG4105CB2 alcohol dehydrogenase KS07_09215 ENOG4105BZ8 glutamate synthase KS07_09220 ENOG4105CBC glutamate synthase KS07_09225 ENOG4105C5Q Transcriptional regulator KS07_09230 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KS07_09255 ENOG4108UB7 KS07_09260 ENOG4105IE8 Alpha-ketoglutarate permease KS07_09265 ENOG4107U6E carbohydrate kinase FGGY KS07_09270 ENOG4108M3J Dehydrogenase KS07_09275 ENOG4108J2R molybdopterin oxidoreductase KS07_09300 ENOG4106ANW SMI1_KNR4 KS07_09305 ENOG4106BHF KS07_09310 ENOG4108Z7R Chaperone CsaA KS07_09315 ENOG4105FTV AraC Family Transcriptional Regulator KS07_09325 ENOG4108W8B Beta-lactamase domain protein KS07_09335 ENOG4105KTU Transcriptional regulator, arsr family KS07_09345 ENOG4108SJC Membrane KS07_09370 ENOG41069ER domain protein KS07_09375 ENOG4105C9U ATP-dependent DNA helicase RecQ KS07_09380 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KS07_09385 ENOG4105SCY DNAK suppressor KS07_09425 ENOG4105C26 Dehydrogenase KS07_09430 ENOG4105EWU Squalene--hopene cyclase KS07_09435 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KS07_09440 ENOG4105C8J )-transporter KS07_09445 ENOG4105C09 Bile acid KS07_09455 ENOG4105C7S Dehydrogenase KS07_09460 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 KS07_09465 ENOG4107T89 von Willebrand factor, type A KS07_09470 ENOG4105GMT ATPase associated with various cellular activities aaa_5 KS07_09480 ENOG4105K4H Nlp p60 protein KS07_09485 ENOG41087PP glycosyltransferase MGT family KS07_09495 ENOG4107QMU Mate efflux family protein KS07_09500 ENOG4106SCS STAS domain KS07_09520 ENOG4105FR1 rard protein KS07_09535 ENOG41090U3 tautomerase KS07_09555 ENOG4105FBA Phospholipase Carboxylesterase KS07_09570 ENOG4105E1V na solute symporter KS07_09580 ENOG4105CS2 ec 3.2.1.21 KS07_09585 ENOG4108S3Y transcriptional regulator KS07_09605 ENOG4108VXD carboxy-peptidase KS07_09610 ENOG4105D3A purine nucleoside phosphorylase DeoD-type KS07_09620 ENOG4106Z5R KS07_09625 ENOG410841Q phosphoesterase PA-phosphatase related protein KS07_09660 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein KS07_09665 ENOG4108TSC N-acetyltransferase KS07_09670 ENOG4107S4Y M20 DapE family protein YgeY KS07_09685 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KS07_09690 ENOG4105FTQ Dna gyrase KS07_09730 ENOG4105C5E polysaccharide biosynthesis protein KS07_09735 ENOG4105E0X reductase KS07_09740 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KS07_09750 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) KS07_09755 ENOG41090WU lipolytic protein G-D-S-L family KS07_09760 ENOG4108KF3 Electron transport protein SCO1 SenC KS07_09770 ENOG4105C7B Threonine dehydratase KS07_09780 ENOG4108UT2 hemolysin iii KS07_09790 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KS07_09795 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) KS07_09805 ENOG4107YX5 Pfam:DUF548 KS07_09810 ENOG4108Y6J UPF0403 protein KS07_09815 ENOG4105C01 Dihydroxy-acid dehydratase KS07_09830 ENOG4108V06 Glutathione peroxidase KS07_09835 ENOG4105CVG Homoserine O-transsuccinylase KS07_09875 ENOG41081VK Ribonuclease KS07_09900 ENOG410890F Dynamin family KS07_09910 ENOG41065KQ synthase KS07_09930 ENOG410900G Protein of unknown function (DUF421) KS07_09990 ENOG41068G1 KS07_10000 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KS07_10010 ENOG4108FKH Transglycosylase SLT domain KS07_10130 ENOG4105QBX endodeoxyribonuclease RusA KS07_10185 ENOG4108ZUE Phage regulatory protein rha KS07_10200 ENOG41067QW Transcriptional regulator KS07_10205 ENOG4105VTR Integrase KS07_10210 ENOG4105C2W permease KS07_10215 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) KS07_10220 ENOG4105CTD carboxy-peptidase KS07_10225 ENOG4105DVT helicase KS07_10235 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) KS07_10240 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) KS07_10245 ENOG4108UKS UPF0398 protein KS07_10255 ENOG4107X2U Inherit from COG: Exonuclease-like protein KS07_10260 ENOG4108I5C dEAD DEAH box helicase KS07_10305 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) KS07_10310 ENOG4105BZ4 penicillin-binding protein KS07_10320 ENOG4105CSM endonuclease III KS07_10330 ENOG4105C5S asparaginyl-tRNA synthetase KS07_10335 ENOG4105CHM Aminotransferase KS07_10345 ENOG4105YAC KS07_10350 ENOG4105DVT helicase KS07_10355 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) KS07_10365 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) KS07_10375 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate KS07_10380 ENOG4105CPK Glycosyl transferase (Group 1 KS07_10385 ENOG4105FJR Lmbe family KS07_10390 ENOG4108Z5K methylglyoxal synthase KS07_10395 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) KS07_10400 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase KS07_10405 ENOG4108JYZ YitT family KS07_10410 ENOG4105F0F Oxalate decarboxylase KS07_10430 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) KS07_10450 ENOG41068YB TPR repeat-containing protein KS07_10455 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase KS07_10465 ENOG4105CIH Imidazole acetol-phosphate transaminase KS07_10475 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) KS07_10480 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase KS07_10485 ENOG4105DK0 Indole-3-glycerol phosphate synthase KS07_10495 ENOG4105CRQ synthase (Component I) KS07_10500 ENOG4105KHN chorismate mutase KS07_10510 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase KS07_10515 ENOG4105BZU Histidine kinase KS07_10520 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) KS07_10525 ENOG4105EAH synthase KS07_10530 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KS07_10535 ENOG4105XXQ heptaprenyl diphosphate synthase component I KS07_10540 ENOG4105WP2 Tryptophan RNA-binding attenuator protein KS07_10545 ENOG4105EUJ GTP cyclohydrolase i KS07_10550 ENOG4105K70 DNA-binding protein KS07_10555 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) KS07_10570 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase KS07_10575 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) KS07_10595 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) KS07_10600 ENOG4105CAT Cytidine monophosphate kinase KS07_10615 ENOG4105MSI germination protein ypeb KS07_10625 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) KS07_10630 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase KS07_10645 ENOG4107RGJ metallophosphoesterase KS07_10660 ENOG4105I7S Abortive infection protein KS07_10665 ENOG4105C9U ATP-dependent DNA helicase RecQ KS07_10670 ENOG4105T7X KS07_10680 ENOG4108SAX Membrane KS07_10685 ENOG4108JQ1 Dehydrogenase KS07_10700 ENOG4105BZU Histidine kinase KS07_10705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS07_10710 ENOG4105CRE cytochrome C KS07_10715 ENOG4107TWT Cytochrome c biogenesis protein KS07_10725 ENOG4105FE9 pseudouridine synthase KS07_10735 ENOG4108JIC nucleoside recognition domain protein KS07_10740 ENOG4105DZ1 carboxypeptidase KS07_10750 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) KS07_10755 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) KS07_10770 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) KS07_10775 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) KS07_10780 ENOG4108R6K riboflavin synthase, subunit alpha KS07_10805 ENOG4107ZE5 PPIases accelerate the folding of proteins KS07_10810 ENOG4105PTM secreted protein KS07_10815 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KS07_10825 ENOG4105G6R Stage v sporulation protein ae KS07_10835 ENOG4105CZ3 stage V sporulation protein ad KS07_10840 ENOG41090VF Stage v sporulation protein ac KS07_10855 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS07_10860 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KS07_10865 ENOG41082AN stage II sporulation protein KS07_10870 ENOG4105DZ1 carboxypeptidase KS07_10875 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) KS07_10880 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) KS07_10885 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KS07_10895 ENOG4105I3K Ferric uptake regulator, Fur family KS07_10900 ENOG4105MZ9 stage II sporulation protein m KS07_10920 ENOG4105DFD Na H antiporter KS07_10925 ENOG4108IJ0 Aspartate ammonia-lyase KS07_10930 ENOG4105HDK L-asparaginase KS07_10935 ENOG4108IMY Transcriptional regulator KS07_10945 ENOG4108YZ4 nudix hydrolase KS07_10955 ENOG4105CPC Aldo Keto reductase KS07_10975 ENOG4106HZJ KS07_10980 ENOG4105RHY Pfam:UPF0157 KS07_10985 ENOG4105KAC Antibiotic biosynthesis monooxygenase KS07_10990 ENOG4108XET gCN5-related N-acetyltransferase KS07_10995 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KS07_11010 ENOG4105C02 permease KS07_11015 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase KS07_11020 ENOG4105CS9 pantothenic acid kinase KS07_11030 ENOG4108IXY short-chain dehydrogenase reductase KS07_11035 ENOG41069FQ Metallo-beta-lactamase superfamily KS07_11040 ENOG4105II7 pyrroline-5-carboxylate reductase KS07_11045 ENOG4108KQ6 Enoyl-CoA hydratase KS07_11050 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KS07_11055 ENOG4106A3M Cytochrome p-450 KS07_11070 ENOG4105C0W non-ribosomal peptide synthetase KS07_11075 ENOG4105C0W non-ribosomal peptide synthetase KS07_11085 ENOG4105C0W non-ribosomal peptide synthetase KS07_11095 ENOG4105CHR reductase KS07_11100 ENOG4105CEY Amp-dependent synthetase and ligase KS07_11115 ENOG4107QKG PfaD family KS07_11120 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KS07_11125 ENOG4108K70 Transcriptional regulator KS07_11135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KS07_11145 ENOG410861F 50S ribosomal protein L33 KS07_11150 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) KS07_11155 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KS07_11160 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) KS07_11165 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KS07_11175 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) KS07_11180 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KS07_11185 ENOG4108HNZ carboxyl transferase KS07_11190 ENOG4108ZVT methylmalonyl-coA epimerase KS07_11200 ENOG4108VZI ErfK ybiS ycfS ynhG family protein KS07_11205 ENOG4108QEG Membrane KS07_11210 ENOG4105CDA abc transporter atp-binding protein KS07_11215 ENOG4105E5Q amino acid AbC transporter KS07_11220 ENOG4108HW3 (ABC) transporter KS07_11225 ENOG4108Y6J UPF0403 protein KS07_11230 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) KS07_11235 ENOG4105C7S Dehydrogenase KS07_11240 ENOG4105CPP Dehydrogenase, E1 component KS07_11255 ENOG4105CKM Branched-chain carboxylic acid kinase KS07_11260 ENOG4107RDP Dehydrogenase KS07_11270 ENOG4108JUB Transcriptional regulator KS07_11275 ENOG4106CCJ Protein of unknown function (DUF2627) KS07_11280 ENOG4105CR4 methylisocitrate lyase KS07_11285 ENOG4105DXD 2-methylcitrate dehydratase KS07_11295 ENOG4105C1G acyl-Coa dehydrogenase KS07_11300 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KS07_11310 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KS07_11315 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KS07_11340 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KS07_11355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KS07_11360 ENOG4107QQR Sporulation KS07_11365 ENOG4105S1Z Stage IV sporulation protein B KS07_11370 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) KS07_11375 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) KS07_11380 ENOG4105DX0 Hemolysin A KS07_11385 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) KS07_11390 ENOG4105CTB Polyprenyl synthetase KS07_11395 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KS07_11400 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KS07_11405 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) KS07_11410 ENOG4105M7K Involved in the transcription termination process (By similarity) KS07_11415 ENOG4108ZSR alkaline shock protein KS07_11420 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KS07_11440 ENOG410644B Stage III sporulation protein af KS07_11450 ENOG4105KQ4 Stage iii sporulation protein ad KS07_11455 ENOG4108CQH stage III sporulation protein AC KS07_11460 ENOG4105KR5 Stage iii sporulation protein KS07_11465 ENOG4105CD2 stage iii sporulation protein aa KS07_11475 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) KS07_11480 ENOG4105DC7 peptidase M24 KS07_11490 ENOG4105CBJ Metal-dependent enzyme KS07_11510 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) KS07_11515 ENOG4105WZW rhodanese family KS07_11520 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor KS07_11530 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KS07_11535 ENOG4105C0D helicase KS07_11550 ENOG4108IMY Transcriptional regulator KS07_11560 ENOG4105VFR signal peptidase KS07_11620 ENOG4105C37 (CBS) domain KS07_11645 ENOG4105C5X domain protein KS07_11690 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase KS07_11695 ENOG4105WDJ 50S ribosomal protein L33 KS07_11705 ENOG41068DG YceG-like family KS07_11710 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KS07_11715 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KS07_11720 ENOG4105E2Z phosphate ABC transporter (Permease KS07_11725 ENOG4105C8U phosphate abc transporter KS07_11730 ENOG4105CVA phosphate KS07_11735 ENOG4107RF6 penicillin-binding protein KS07_11745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KS07_11750 ENOG4105SXS Protein of unknown function (DUF456) KS07_11765 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) KS07_11770 ENOG41063Y9 KS07_11775 ENOG4108U5J '-nucleotidase KS07_11780 ENOG4105N80 Ferric uptake regulator, Fur family KS07_11785 ENOG4108JYZ YitT family KS07_11790 ENOG41069ZM Protein of unknown function (DUF2624) KS07_11795 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) KS07_11810 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) KS07_11815 ENOG4105EGD dinuclear metal center protein, YbgI family KS07_11830 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS07_11835 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) KS07_11840 ENOG4108UPT UPF0178 protein KS07_11845 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) KS07_11855 ENOG4105C38 Glycyl-tRNA synthetase beta subunit KS07_11860 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit KS07_11865 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) KS07_11875 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) KS07_11880 ENOG4105KG3 cytidine deaminase KS07_11885 ENOG4107YR5 Diacylglycerol kinase KS07_11890 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) KS07_11895 ENOG4105CTJ Metal Dependent Phosphohydrolase KS07_11900 ENOG4105C9A Phoh family KS07_11905 ENOG4105EI1 sporulation protein yqfd KS07_11910 ENOG41068P3 sporulation protein YqfC KS07_11920 ENOG4105DI5 UPF0365 protein KS07_11925 ENOG4105F7J membrane-bound serine protease KS07_11930 ENOG4105KTH gatB Yqey KS07_11945 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KS07_11950 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) KS07_11955 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) KS07_11960 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) KS07_11965 ENOG4105CFG Acts as a chaperone (By similarity) KS07_11970 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KS07_11975 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) KS07_11980 ENOG4105CSA Coproporphyrinogen iii oxidase KS07_11985 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) KS07_11995 ENOG4108ZRV stage ii sporulation protein p KS07_12000 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) KS07_12005 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) KS07_12010 ENOG4105TQK DNA polymerase iii, delta' subunit KS07_12020 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KS07_12025 ENOG4108UK2 deaminase KS07_12030 ENOG4105KQC Competence protein KS07_12040 ENOG4108D32 Methyltransferase KS07_12050 ENOG4108WF2 Metal Dependent Phosphohydrolase KS07_12055 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) KS07_12060 ENOG410812S Rna-binding protein KS07_12065 ENOG4105E2X shikimate dehydrogenase KS07_12070 ENOG4105CQW ribosome biogenesis GTPase YqeH KS07_12075 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase KS07_12095 ENOG41080BT SNARE associated Golgi KS07_12110 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS07_12145 ENOG4108SWU Histidine kinase KS07_12150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS07_12155 ENOG4105DHF Membrane KS07_12160 ENOG4108UYN gCN5-related N-acetyltransferase KS07_12165 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KS07_12175 ENOG4108J8C transporter major facilitator family protein KS07_12180 ENOG4108U7W acetyltransferase KS07_12195 ENOG4105DQF Hydrolase KS07_12210 ENOG4105DG6 mannose-6-phosphate isomerase KS07_12215 ENOG4105DM4 PTS System KS07_12230 ENOG4108Z66 YbaK ebsC protein KS07_12235 ENOG4107RSM transcriptional regulator KS07_12240 ENOG4105D94 Major Facilitator Superfamily KS07_12245 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KS07_12250 ENOG41082JN Transcriptional regulator KS07_12270 ENOG4105TMB Formate nitrite transporter KS07_12275 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) KS07_12280 ENOG4108JB9 formate dehydrogenase KS07_12295 ENOG4105C28 cystathionine KS07_12325 ENOG4107XRG penicillin-binding protein KS07_12330 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) KS07_12340 ENOG4105CFP Peptidase U32 KS07_12345 ENOG4105XYU peptidase (U32 family) KS07_12350 ENOG4108VQJ O-methyltransferase KS07_12355 ENOG4105HHA aminodeoxychorismate lyase KS07_12365 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) KS07_12370 ENOG4105VBH UPF0297 protein KS07_12375 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KS07_12380 ENOG4105C02 permease KS07_12385 ENOG4105CDA abc transporter atp-binding protein KS07_12390 ENOG4105CT1 (ABC) transporter KS07_12395 ENOG4105EAD ABC transporter KS07_12400 ENOG4105DRP amino acid AbC transporter KS07_12410 ENOG41060CR KS07_12420 ENOG4105C7H Helicase, RecD TraA family KS07_12430 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) KS07_12435 ENOG4105C3J Cysteine desulfurase KS07_12445 ENOG4105D1H recombination factor protein RarA KS07_12450 ENOG4105CUZ uba thif-type nad fad binding protein KS07_12460 ENOG4105C9M aspartyl-trna synthetase KS07_12465 ENOG4105CUT histidyl-tRNA synthetase KS07_12475 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KS07_12480 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) KS07_12485 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) KS07_12495 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) KS07_12500 ENOG41067VP Protein of unknown function (DUF1049) KS07_12505 ENOG4105NCW Trka-c domain protein KS07_12510 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KS07_12520 ENOG4105CKP Polysaccharide Biosynthesis Protein KS07_12525 ENOG4108QG2 Membrane KS07_12530 ENOG4105NAP KS07_12535 ENOG4105VIE preprotein translocase, subunit YajC KS07_12540 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) KS07_12545 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) KS07_12555 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) KS07_12560 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) KS07_12580 ENOG4106678 morphogenetic protein associated with SpoVID KS07_12585 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) KS07_12590 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase KS07_12595 ENOG4108IYU L-aspartate oxidase KS07_12610 ENOG4105CQC Prephenate dehydratase KS07_12620 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KS07_12630 ENOG4105K46 50S ribosomal protein l27 KS07_12635 ENOG4105X36 (ribosomal) protein KS07_12640 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) KS07_12655 ENOG4107QMS site-determining protein KS07_12660 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) KS07_12665 ENOG4105YHC Rod shape-determining protein MreD KS07_12670 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) KS07_12675 ENOG4105DFF Rod shape-determining protein mreb KS07_12680 ENOG4105W5Q DNA repair protein (RadC KS07_12685 ENOG4108Z03 MAF-like protein KS07_12695 ENOG4106A3R peptidase KS07_12700 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase KS07_12705 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) KS07_12715 ENOG4106AR7 Spore coat protein KS07_12720 ENOG41068KH stage VI sporulation protein D KS07_12725 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KS07_12730 ENOG4105D52 delta-aminolevulinic acid dehydratase KS07_12740 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) KS07_12750 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) KS07_12760 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) KS07_12765 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) KS07_12770 ENOG4108IUQ atp-dependent protease KS07_12775 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) KS07_12780 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation KS07_12790 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KS07_12795 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KS07_12800 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KS07_12810 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KS07_12815 ENOG4108ZP8 Acetolactate synthase small subunit KS07_12820 ENOG4105C7K acetolactate synthase KS07_12845 ENOG4105M59 Phosphodiesterase, mj0936 family KS07_12850 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) KS07_12855 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) KS07_12860 ENOG4108XJQ germination protein KS07_12865 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KS07_12870 ENOG41067TZ transcriptional regulator, MarR family KS07_12875 ENOG4105PFC Transcriptional regulator KS07_12885 ENOG4105E33 succinate dehydrogenase KS07_12895 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit KS07_12910 ENOG4105CFH Aspartokinase KS07_12915 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) KS07_12920 ENOG4105K63 Thioredoxin KS07_12925 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KS07_12930 ENOG4105C10 Electron transfer flavoprotein KS07_12935 ENOG4105BZJ Electron transfer flavoprotein KS07_12940 ENOG41060WC Enoyl-CoA hydratase KS07_12945 ENOG4107Z3H Transcriptional regulator, TetR family KS07_12950 ENOG4105CEY Amp-dependent synthetase and ligase KS07_12955 ENOG4108YV3 Protein of unknown function (DUF2711) KS07_12965 ENOG4105C98 muts2 protein KS07_12970 ENOG4105DCG PHP domain protein KS07_12985 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KS07_12990 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) KS07_12995 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) KS07_13000 ENOG4108RWN rrna methyltransferase KS07_13005 ENOG41067MF small acid-soluble spore protein KS07_13015 ENOG4105CQB FAD linked oxidase domain protein KS07_13020 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KS07_13030 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KS07_13035 ENOG4105DRS transport system, permease KS07_13050 ENOG4108MDK Dehydrogenase KS07_13060 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase KS07_13065 ENOG4105EF1 ribulokinase KS07_13075 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase KS07_13080 ENOG4105CN9 Peptidase m42 family protein KS07_13090 ENOG410696E Membrane KS07_13095 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) KS07_13100 ENOG4105VJV 50s ribosomal protein L35 KS07_13105 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) KS07_13110 ENOG41067MG lrgb family KS07_13120 ENOG4105DY9 regulatoR KS07_13125 ENOG4108HRK Histidine kinase KS07_13130 ENOG4105U0R haloacid dehalogenase-like hydrolase KS07_13135 ENOG4105C22 threonyL-tRNA synthetase KS07_13140 ENOG4108TDW sporulation protein YtxC KS07_13165 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KS07_13170 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KS07_13175 ENOG4105KVH Transcriptional regulator KS07_13180 ENOG4105F27 Major Facilitator KS07_13185 ENOG4105CV8 reductase KS07_13190 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) KS07_13200 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) KS07_13205 ENOG4105C2M dna polymerase I KS07_13210 ENOG4105BZU Histidine kinase KS07_13215 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS07_13225 ENOG4108HMX isocitrate dehydrogenase (NADP) KS07_13230 ENOG4105BZN citrate synthase KS07_13235 ENOG410780I phosphoprotein phosphatase activity KS07_13255 ENOG4105G7B Protein of unknown function (DUF2992) KS07_13265 ENOG4108REF Sporulation integral membrane protein ytvi KS07_13270 ENOG4105FS0 cytoplasmic membrane protein KS07_13275 ENOG4105CA9 Pyruvate kinase KS07_13280 ENOG4105CTQ phosphohexokinase KS07_13285 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) KS07_13290 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) KS07_13300 ENOG4105C6K Malic enzyme KS07_13305 ENOG4105C0B DNA polymerase III (alpha subunit) KS07_13310 ENOG4105VV2 KS07_13320 ENOG4106EVM KS07_13325 ENOG4105SFS phosphoesterase RecJ domain protein KS07_13340 ENOG4105E8R UPF0173 metal-dependent hydrolase KS07_13355 ENOG4105CH7 arginosuccinase KS07_13360 ENOG4105CDH Citrulline--aspartate ligase KS07_13365 ENOG4105EPU Molybdenum cofactor synthesis domain protein KS07_13370 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KS07_13380 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) KS07_13385 ENOG4105KBJ sporulation protein ytfj KS07_13395 ENOG4105VK3 rdd domain containing protein KS07_13400 ENOG4105D07 Signal peptide peptidase, SppA KS07_13405 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KS07_13410 ENOG4105EFZ amidohydrolase KS07_13415 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KS07_13425 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) KS07_13450 ENOG4105U5Y Transcriptional regulator KS07_13465 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) KS07_13470 ENOG4105C26 Dehydrogenase KS07_13505 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KS07_13530 ENOG4108NGU Transcriptional regulator KS07_13545 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KS07_13555 ENOG4105F1V Acetoin utilization protein KS07_13560 ENOG4105W87 Cbs domain KS07_13565 ENOG4105DGU Histone deacetylase KS07_13570 ENOG4105ER2 Ompa motb domain protein KS07_13575 ENOG4107R0U MotA TolQ exbB proton channel KS07_13580 ENOG4105ETE Transcriptional regulator (LacI family KS07_13585 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase KS07_13605 ENOG4105DFU Cell wall formation (By similarity) KS07_13615 ENOG4108VDD TRNA binding domain protein KS07_13630 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ KS07_13645 ENOG4105C6K Malic enzyme KS07_13650 ENOG4105C8F Beta-lactamase domain protein KS07_13655 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) KS07_13665 ENOG4108V15 phosphotransferase enzyme family KS07_13680 ENOG4107F58 2'-5' rna ligase KS07_13685 ENOG4105C6T cysteine synthase KS07_13690 ENOG4107QSE Dipeptidase KS07_13695 ENOG4105C7N Xanthine uracil vitamin C permease KS07_13710 ENOG4105YW5 deoR family transcriptional regulator KS07_13725 ENOG4105CBX hi0933 family KS07_13730 ENOG4105C94 Transporter KS07_13750 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component KS07_13755 ENOG4105I1K ABC transporter KS07_13770 ENOG41085GJ domain protein KS07_13775 ENOG4105C8T Leucyl-tRNA synthetase KS07_13785 ENOG4105BZU Histidine kinase KS07_13790 ENOG410605W Major Facilitator KS07_13805 ENOG4105C19 ABC transporter KS07_13810 ENOG4105EWM Histidine kinase KS07_13820 ENOG4107R34 abc transporter permease protein KS07_13825 ENOG4105C19 ABC transporter KS07_13845 ENOG4105DVE abc transporter atp-binding protein KS07_13850 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KS07_13870 ENOG4105N5T Radical SAM Protein KS07_13885 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KS07_13895 ENOG4105E8V Alpha Beta Hydrolase Fold protein KS07_13900 ENOG4108Z0R Transferase KS07_13905 ENOG4105C85 amino acid KS07_13910 ENOG4105CAQ asparagine synthetase KS07_13915 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP KS07_13920 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase KS07_13935 ENOG4105D2X ABC transporter substrate-binding protein KS07_13945 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component KS07_13960 ENOG4108RMU ferritin dps family protein KS07_13975 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) KS07_13980 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) KS07_13985 ENOG4108V2W Carbonate dehydratase KS07_13990 ENOG4105NRA 50s ribosomal protein l31 type b KS07_14010 ENOG4105DTQ mandelate racemase muconate lactonizing KS07_14015 ENOG4105CEY Amp-dependent synthetase and ligase KS07_14020 ENOG4108IPT Naphthoate synthase KS07_14025 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) KS07_14030 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) KS07_14035 ENOG4105E4F Isochorismate synthase KS07_14170 ENOG4105N67 Proton-coupled thiamine transporter YuaJ KS07_14175 ENOG4105DZ6 Band 7 protein KS07_14185 ENOG4106DF1 KS07_14190 ENOG4108VNY MOSC domain protein KS07_14195 ENOG4108JB8 alcohol dehydrogenase KS07_14200 ENOG4105C26 Dehydrogenase KS07_14205 ENOG4105TRT Transcriptional regulator KS07_14220 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KS07_14225 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KS07_14265 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KS07_14275 ENOG4105EE0 oxidoreductase KS07_14280 ENOG4108Z0Z intracellular protease Pfpi family KS07_14285 ENOG4105C8Q Methyl-accepting chemotaxis KS07_14290 ENOG4105C8Q Methyl-accepting chemotaxis KS07_14295 ENOG4105C8Q Methyl-accepting chemotaxis KS07_14300 ENOG4105C8Q Methyl-accepting chemotaxis KS07_14315 ENOG4105EA8 2-Nitropropane dioxygenase KS07_14320 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme KS07_14330 ENOG4105C37 (CBS) domain KS07_14345 ENOG4107PBV potassium channel KS07_14350 ENOG4107PBV potassium channel KS07_14365 ENOG4107QYV phosphohexose isomerase KS07_14375 ENOG4105CHJ isochorismatase hydrolase KS07_14385 ENOG4107QW4 alcohol dehydrogenase KS07_14390 ENOG4105WG9 Conserved Protein KS07_14400 ENOG4105CHM Aminotransferase KS07_14405 ENOG4108ZB6 transcriptional regulator AsnC family KS07_14410 ENOG4108MUZ hydrolase KS07_14420 ENOG4105C87 Aminotransferase class I and II KS07_14425 ENOG4108HGU Histidine kinase KS07_14430 ENOG4105Y38 Kinase-associated protein B KS07_14445 ENOG4105BZ4 penicillin-binding protein KS07_14450 ENOG4105KIR Thiol-disulfide oxidoreductase dcc KS07_14465 ENOG4108MRH transcriptional regulatory protein KS07_14470 ENOG4105DIH basic membrane KS07_14475 ENOG4108JQ9 ABC transporter KS07_14480 ENOG4105UIB (ABC) transporter KS07_14495 ENOG4105D65 subunit l KS07_14500 ENOG4105HC0 Na H antiporter KS07_14505 ENOG4108ZE9 Monovalent cation H antiporter subunit C KS07_14510 ENOG4108JPZ Monovalent cation H antiporter subunit D KS07_14515 ENOG4105SC1 monovalent cation H antiporter subunit E KS07_14525 ENOG4105KJM monovalent cation h antiporter subunit g KS07_14530 ENOG4105KA0 thioesterase Superfamily protein KS07_14540 ENOG4105BZU Histidine kinase KS07_14565 ENOG4105D58 Diguanylate phosphodiesterase KS07_14570 ENOG4105DAP Nicotinate phosphoribosyltransferase KS07_14595 ENOG4105C02 permease KS07_14610 ENOG410904N short-chain dehydrogenase reductase KS07_14645 ENOG4108K8K Transcriptional regulator KS07_14650 ENOG4105DCF alanine dehydrogenase KS07_14660 ENOG4105WQT MbtH domain protein KS07_14665 ENOG4105CEY Amp-dependent synthetase and ligase KS07_14670 ENOG4105WQI isochorismatase KS07_14675 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase KS07_14680 ENOG4105E4F Isochorismate synthase KS07_14685 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase KS07_14690 ENOG4105NIV Esterase KS07_14710 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) KS07_14720 ENOG41069ER domain protein KS07_14730 ENOG4105CEP NADH dehydrogenase KS07_14745 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) KS07_14760 ENOG4105CJ1 ABC, transporter KS07_14780 ENOG4105D9U N-acetyltransferase KS07_14785 ENOG4108VHC Short-chain dehydrogenase reductase Sdr KS07_14790 ENOG4108YX9 iron--sulfur cluster insertion protein erpA KS07_14795 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) KS07_14805 ENOG4105ZKE UPF0349 protein KS07_14820 ENOG41083MR nifu domain-containing protein KS07_14825 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein KS07_14830 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) KS07_14835 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) KS07_14840 ENOG4105D6E homoserine dehydrogenase KS07_14850 ENOG4108W5N phosphatidylglycerophosphatase a KS07_14855 ENOG4105D4U had-superfamily hydrolase, subfamily iia KS07_14865 ENOG4105MMD transcriptional regulator KS07_14870 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) KS07_14875 ENOG4105FAA peptidase M23 KS07_14880 ENOG4108YTE sporulation protein YunB KS07_14885 ENOG4107R8B 5'-nucleotidase KS07_14895 ENOG4105I3N Conserved Protein KS07_14905 ENOG4105CD3 dihydroorotase KS07_14910 ENOG4105G9B Transcriptional regulator KS07_14935 ENOG4105C5R Aminotransferase KS07_14945 ENOG4108K8S endonuclease I KS07_14950 ENOG4108IJ9 (ABC) transporter KS07_14955 ENOG4105FDP GntR family transcriptional regulator KS07_14960 ENOG4108KPW sugar kinase KS07_14965 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component KS07_14970 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component KS07_14975 ENOG4105XN3 extracellular solute-binding protein family 1 KS07_14980 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine KS07_14990 ENOG4105PKS Excinuclease abc c subunit domain protein KS07_14995 ENOG4107VFR oxidoreductase KS07_15000 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KS07_15010 ENOG41083Q9 chitosanase KS07_15015 ENOG4105DIW FeS assembly protein SUFB KS07_15020 ENOG4108UNV SUF system FeS assembly protein, NifU family KS07_15025 ENOG4105C9B Cysteine desulfurase KS07_15030 ENOG4105JRK feS assembly protein SufD KS07_15035 ENOG4105C3K feS assembly ATPase SufC KS07_15050 ENOG4105D01 (LipO)protein KS07_15055 ENOG4108UMI ABC transporter, permease KS07_15060 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KS07_15085 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) KS07_15090 ENOG41080E8 Transcriptional regulator, Spx MgsR family KS07_15095 ENOG4105C1G acyl-Coa dehydrogenase KS07_15100 ENOG4105CHU acetyl-coa acetyltransferase KS07_15130 ENOG41067TZ transcriptional regulator, MarR family KS07_15135 ENOG4105C0R drug resistance transporter emrb qaca subfamily KS07_15140 ENOG4105C5Q Transcriptional regulator KS07_15160 ENOG4105E0A ABC, transporter KS07_15175 ENOG4105E1F short-chain dehydrogenase reductase KS07_15180 ENOG4105HUF DNA protection during starvation protein KS07_15185 ENOG4105C0H protease KS07_15195 ENOG4105F3H Histidine kinase KS07_15205 ENOG41067SE Tetr family transcriptional regulator KS07_15210 ENOG4105C9Q fumarate hydratase class II KS07_15235 ENOG4105WH1 Two component transcriptional regulator luxr family KS07_15240 ENOG4105ENE Histidine kinase KS07_15255 ENOG41087YS Phage shock protein A KS07_15270 ENOG4108WBT adenosyltransferase KS07_15275 ENOG4105E0A ABC, transporter KS07_15280 ENOG4105EHG Permease protein KS07_15285 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) KS07_15290 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KS07_15295 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein KS07_15305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS07_15315 ENOG4106DF4 Sigma-70, region 4 KS07_15325 ENOG4105F0F Oxalate decarboxylase KS07_15335 ENOG4105E0A ABC, transporter KS07_15340 ENOG4105EHG Permease protein KS07_15345 ENOG4105DQ5 transport system permease protein KS07_15355 ENOG4105D5Q Arginine ornithine antiporter KS07_15365 ENOG4107K5X Membrane-bound metal-dependent hydrolase KS07_15370 ENOG4107QZ2 Sulfatase KS07_15375 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family KS07_15380 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KS07_15385 ENOG4105E0C molybdate abc transporter KS07_15390 ENOG4105WH1 Two component transcriptional regulator luxr family KS07_15395 ENOG4105BZU Histidine kinase KS07_15400 ENOG4105CJ1 ABC, transporter KS07_15410 ENOG4108KYE ABC-2 type transporter KS07_15425 ENOG4105EEQ Na H antiporter KS07_15435 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) KS07_15440 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KS07_15445 ENOG4105EEM helicase KS07_15450 ENOG4105EN6 Membrane KS07_15465 ENOG4107ZQN disulfide bond KS07_15470 ENOG4105C59 p-type ATPase KS07_15475 ENOG4105C59 p-type ATPase KS07_15480 ENOG410681U heavy metal transport detoxification protein KS07_15485 ENOG4105VPX protein, conserved in bacteria KS07_15490 ENOG4105D9R oxidoreductase KS07_15495 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KS07_15510 ENOG4105DEN Luciferase family KS07_15515 ENOG4105CDA abc transporter atp-binding protein KS07_15540 ENOG4108XSB acetyltransferase, (GNAT) family KS07_15545 ENOG4108KSA LysR family transcriptional regulator KS07_15550 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KS07_15555 ENOG41067XF inhibitor KS07_15575 ENOG4105XZU Preprotein translocase, subunit SecG KS07_15595 ENOG4105KVH Transcriptional regulator KS07_15620 ENOG4105DA5 (ABC) transporter KS07_15625 ENOG4105R40 Glycine betaine carnitine choline KS07_15630 ENOG4108HQR Glycine betaine KS07_15635 ENOG4105E90 ABC transporter KS07_15640 ENOG4108IJ8 ABC transporter KS07_15645 ENOG4107HG4 Transcriptional regulator KS07_15650 ENOG4105R40 Glycine betaine carnitine choline KS07_15655 ENOG4108HQR Glycine betaine KS07_15660 ENOG4105E90 ABC transporter KS07_15665 ENOG4108IJ8 ABC transporter KS07_15670 ENOG4107HG4 Transcriptional regulator KS07_15675 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein KS07_15685 ENOG4105T65 Membrane-associated protein KS07_15690 ENOG4108W0I acetyltransferase KS07_15705 ENOG4105FJR Lmbe family KS07_15725 ENOG4108IAJ Nad-dependent epimerase dehydratase KS07_15730 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KS07_15735 ENOG4107QQG Dehydrogenase KS07_15740 ENOG4105IIU Aminopeptidase KS07_15745 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) KS07_15750 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) KS07_15755 ENOG4105CP7 Triose-phosphate isomerase KS07_15760 ENOG4105BZA Phosphoglycerate kinase KS07_15770 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KS07_15785 ENOG4105CMD Transcriptional regulator, GntR family KS07_15790 ENOG4105DEN Luciferase family KS07_15805 ENOG4107RT3 EamA-like transporter family KS07_15830 ENOG410667J hydrolase KS07_15835 ENOG4106KNT transcriptional regulator KS07_15840 ENOG4105CMG Carbohydrate kinase KS07_15845 ENOG4105C6Z Gluconate KS07_15855 ENOG4107QR9 Iron-sulfur cluster binding protein KS07_15860 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KS07_15865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KS07_15870 ENOG4105JXH GntR family transcriptional regulator KS07_15875 ENOG4105DAA L-lactate KS07_15880 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KS07_15890 ENOG4108ZPC Polysaccharide pyruvyl transferase KS07_15895 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KS07_15900 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family KS07_15905 ENOG4105D3Q Sugar transferase KS07_15915 ENOG4105K64 Glycosyl transferase, family 2 KS07_15925 ENOG4107QRS glycosyltransferase group 2 family protein KS07_15930 ENOG41068W6 Capsular polysaccharide biosynthesis protein KS07_15935 ENOG4108KMV Glycosyl transferase (Group 1 KS07_15940 ENOG4105K64 Glycosyl transferase, family 2 KS07_15945 ENOG4108PQP glycosyl transferase group 1 KS07_15955 ENOG4108QV3 biosynthesis protein KS07_15960 ENOG4105HTX biosynthesis protein KS07_15970 ENOG4105EBR Carboxylesterase KS07_15980 ENOG4105NAE bifunctional deaminase-reductase domain protein KS07_15990 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 KS07_15995 ENOG4105PY6 Phenolic acid decarboxylase KS07_16040 ENOG4108HKT sucrose-6-phosphate hydrolase KS07_16045 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) KS07_16050 ENOG4105ETE Transcriptional regulator (LacI family KS07_16055 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KS07_16060 ENOG4108KAM Transcriptional regulator KS07_16065 ENOG4105C7F AcnD-accessory protein PrpF KS07_16075 ENOG4108URH decarboxylase KS07_16080 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain KS07_16085 ENOG4105CHH sulfate transporter KS07_16090 ENOG4108V2W Carbonate dehydratase KS07_16100 ENOG4105C5I Dehydrogenase KS07_16105 ENOG4105GGE ribonuclease KS07_16110 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase KS07_16115 ENOG4105KRI phosphocarrier protein (HPr KS07_16120 ENOG4105CIE May be required for sporulation (By similarity) KS07_16125 ENOG4105CHW UPF0052 protein KS07_16130 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) KS07_16135 ENOG4108Z4K mutator MutT protein KS07_16140 ENOG4105C3M thioredoxin reductase KS07_16155 ENOG4105BZU Histidine kinase KS07_16160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS07_16165 ENOG4105BZ1 (ABC) transporter KS07_16170 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase KS07_16175 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) KS07_16180 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase KS07_16185 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) KS07_16190 ENOG4105ECC imidazole-glycerol-phosphate dehydratase KS07_16195 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) KS07_16200 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) KS07_16205 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) KS07_16215 ENOG4108S4C acetyltransferase KS07_16220 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) KS07_16230 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) KS07_16235 ENOG4105CE4 GlcNAc 6-P deacetylase KS07_16240 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) KS07_16245 ENOG4105FDP GntR family transcriptional regulator KS07_16250 ENOG4105J7D transcriptional regulator KS07_16255 ENOG41088CQ domain protein KS07_16260 ENOG41086DT Membrane protein of unknown function KS07_16265 ENOG41067S9 phage shock protein C, PspC KS07_16270 ENOG4108PY7 KS07_16285 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KS07_16290 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) KS07_16305 ENOG4105MKU Transcriptional regulator KS07_16325 ENOG4105CN1 protease KS07_16330 ENOG4108M26 parallel beta-helix repeat protein KS07_16335 ENOG4105CRP Part of the ABC transporter FtsEX involved in KS07_16340 ENOG4105CAK Cell division ATP-binding protein ftsE KS07_16355 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) KS07_16360 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving KS07_16365 ENOG4105MS2 ribosomal subunit Interface protein KS07_16380 ENOG4105MQ3 flagellar protein FliS KS07_16385 ENOG4107RT6 flagellar hook-associated KS07_16390 ENOG4105I03 Flagellin KS07_16395 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) KS07_16400 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) KS07_16410 ENOG4105DTJ flagellar hook-associated protein KS07_16415 ENOG4105E1Q flagellar hook-associated protein KS07_16430 ENOG4105RU3 KS07_16435 ENOG41081UC Inherit from COG: Competence protein KS07_16455 ENOG4105WH1 Two component transcriptional regulator luxr family KS07_16465 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein KS07_16470 ENOG4108KGH TRANSCRIPTIONal KS07_16475 ENOG4105ESV Glycosyl transferase, family 4 KS07_16480 ENOG4107EF8 Glycosyl transferase (Group 1 KS07_16495 ENOG4105QZI O-Antigen Polymerase KS07_16500 ENOG4105C6Y Udp-glucose 6-dehydrogenase KS07_16505 ENOG4107RA4 Glycosyl transferase (Group 1 KS07_16510 ENOG4105PSV Polysaccharide Biosynthesis Protein KS07_16515 ENOG4105D3Q Sugar transferase KS07_16520 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KS07_16525 ENOG4105JFG SpoIID LytB domain protein KS07_16540 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase KS07_16545 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KS07_16550 ENOG4105EY8 ABC transporter KS07_16560 ENOG4107SJB teichoic acid biosynthesis KS07_16570 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase KS07_16580 ENOG4107RZX Teichoic acid biosynthesis protein KS07_16590 ENOG4105DG6 mannose-6-phosphate isomerase KS07_16605 ENOG4108NHD germination protein KS07_16610 ENOG4108SHN Glycosyl transferase, family 2 KS07_16615 ENOG4105C54 Major Facilitator superfamily KS07_16620 ENOG4108KGH TRANSCRIPTIONal KS07_16625 ENOG4105J7I hydrolase KS07_16630 ENOG4106UBQ KS07_16635 ENOG4105K4H Nlp p60 protein KS07_16645 ENOG4105PNM synthesis protein KS07_16655 ENOG4105N98 Capsule biosynthesis protein capB KS07_16660 ENOG4105E1K spore germination protein KS07_16675 ENOG4105ETE Transcriptional regulator (LacI family KS07_16680 ENOG4108RVA ribokinase KS07_16685 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) KS07_16690 ENOG4105C2J ABC transporter KS07_16695 ENOG4105CNN ABC, transporter KS07_16700 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KS07_16710 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KS07_16715 ENOG4107FQX Alpha-acetolactate decarboxylase KS07_16725 ENOG4107RSM transcriptional regulator KS07_16740 ENOG4106UIA KS07_16755 ENOG4107XC4 flavin reductase domain protein, FMN-binding KS07_16765 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KS07_16775 ENOG4105CAH Chromate KS07_16780 ENOG4105FGV Chromate KS07_16790 ENOG4108WS4 fmn reductase KS07_16795 ENOG4107V2S Transcriptional regulator KS07_16800 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) KS07_16830 ENOG4108XI2 Domain of unknown function (DUF1963) KS07_16835 ENOG4105C6Y Udp-glucose 6-dehydrogenase KS07_16840 ENOG4108RB3 Capsular polysaccharide biosynthesis protein KS07_16845 ENOG4107YJ4 chain length determinant protein KS07_16850 ENOG4105HTX biosynthesis protein KS07_16860 ENOG4105KBK Zinc finger, swim domain protein KS07_16865 ENOG4105C0D helicase KS07_16870 ENOG410667J hydrolase KS07_16875 ENOG4105E98 transcriptional regulator DeoR family KS07_16880 ENOG4105Z8H single-stranded DNA-binding protein KS07_16895 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) KS07_16900 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) KS07_16910 ENOG4105CGA flagellar basal-body rod protein FlgG KS07_16920 ENOG4105DFF Rod shape-determining protein mreb KS07_16925 ENOG4105MT0 Sporulation transcriptional regulator spoiiid KS07_16930 ENOG4107MII Sugar-specific transcriptional regulator TrmB KS07_16935 ENOG4105CZM Major Facilitator KS07_16940 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease KS07_16945 ENOG41080V3 Major Facilitator superfamily KS07_16950 ENOG4105D3W isochorismatase KS07_16955 ENOG4105BZU Histidine kinase KS07_16965 ENOG4105CNI cell division protein FtsW KS07_16970 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase KS07_16980 ENOG4105FRN stage II sporulation protein KS07_16985 ENOG4107TCE N-acetyltransferase KS07_17000 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KS07_17005 ENOG4106BRK KS07_17015 ENOG4107T94 Endo-14-beta-xylanase KS07_17020 ENOG4108Z40 Transcriptional regulator KS07_17025 ENOG4105CQM Urea amidohydrolase subunit alpha KS07_17030 ENOG4105KI2 Urea amidohydrolase subunit beta KS07_17035 ENOG4108YZ9 Urea amidohydrolase subunit gamma KS07_17055 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KS07_17060 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KS07_17070 ENOG4108TF4 von Willebrand factor, type A KS07_17085 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KS07_17095 ENOG4106778 Protein of unknown function (DUF1146) KS07_17105 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) KS07_17110 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) KS07_17115 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) KS07_17120 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) KS07_17125 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) KS07_17140 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) KS07_17150 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) KS07_17155 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) KS07_17160 ENOG4108UIC UPF0340 protein KS07_17165 ENOG4108YZG isomerase KS07_17170 ENOG4107WAU Protein tyrosine phosphatase KS07_17175 ENOG410815N Probably functions as a manganese efflux pump (By similarity) KS07_17180 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KS07_17190 ENOG4108ZXQ stage ii sporulation protein r KS07_17205 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KS07_17210 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) KS07_17215 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase KS07_17225 ENOG4107TT2 Auxin Efflux Carrier KS07_17230 ENOG4105C6K Malic enzyme KS07_17235 ENOG4107104 thymidine kinase KS07_17240 ENOG41082DI 50s ribosomal protein l31 KS07_17245 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) KS07_17255 ENOG4105CBT Fructose-1,6-bisphosphatase KS07_17260 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KS07_17270 ENOG4105D2N Aldolase KS07_17275 ENOG410812K response regulator receiver protein KS07_17285 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) KS07_17295 ENOG4105DF6 Fe-S oxidoreductase KS07_17305 ENOG4105E5J UV damage endonuclease KS07_17315 ENOG4105BZ1 (ABC) transporter KS07_17320 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KS07_17335 ENOG4105R3A Nitrate reductase KS07_17340 ENOG4108IUE nitrate reductase beta subunit KS07_17360 ENOG4107V6Q Cyclic nucleotide-binding domain KS07_17370 ENOG4105C75 arginyL-tRNA synthetase KS07_17375 ENOG410684U Domain of unknown function (DUF1934) KS07_17400 ENOG4107JM4 Tetratricopeptide repeat KS07_17445 ENOG4105CYW agmatinase KS07_17450 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) KS07_17455 ENOG4105BZ4 penicillin-binding protein KS07_17465 ENOG4108XFG YwhD family KS07_17470 ENOG4108Z4T Peptidase M50 KS07_17475 ENOG41069HH 4-oxalocrotonate tautomerase KS07_17480 ENOG41067TZ transcriptional regulator, MarR family KS07_17485 ENOG4105CUB amino acid KS07_17495 ENOG4105DCI Phosphohydrolase KS07_17505 ENOG4108VCI transcription factor, rsfa family KS07_17510 ENOG4105K7K Transcriptional regulator KS07_17520 ENOG4105CJ1 ABC, transporter KS07_17525 ENOG4108TU7 Inherit from COG: (ABC) transporter KS07_17550 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) KS07_17555 ENOG4105DUM transcriptional regulator, lysR family KS07_17560 ENOG4105HMI Membrane KS07_17565 ENOG4108IJ2 phosphate acetyltransferase KS07_17570 ENOG4107JTW chlorite dismutase KS07_17580 ENOG4105CHM Aminotransferase KS07_17610 ENOG4105FCW Major Facilitator superfamily KS07_17615 ENOG4105C2C drug resistance transporter, Bcr CflA KS07_17630 ENOG4105C26 Dehydrogenase KS07_17635 ENOG4105D82 Glutamate dehydrogenase KS07_17645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KS07_17665 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase KS07_17670 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase KS07_17675 ENOG4105C1B dTDP-glucose 4-6-dehydratase KS07_17680 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) KS07_17685 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG KS07_17690 ENOG4107TY6 Acylneuraminate cytidylyltransferase KS07_17700 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD KS07_17705 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KS07_17740 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) KS07_17745 ENOG4108RJ9 Glycosyl transferase, family 2 KS07_17765 ENOG4105DWF phosphomethylpyrimidine kinase KS07_17780 ENOG4105C5Y PTS System KS07_17800 ENOG4105DEN Luciferase family KS07_17805 ENOG4108DBC nitroreductase KS07_17815 ENOG4105I4A GCN5-related N-acetyltransferase KS07_17835 ENOG4105BZ9 Cytochrome C oxidase, subunit I KS07_17840 ENOG4105E2S oxidase) subunit II KS07_17845 ENOG4107BMA Transglycosylase associated protein KS07_17855 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) KS07_17860 ENOG4105WH5 Teichoic acid glycosylation protein KS07_17885 ENOG4107ZXU DSBA oxidoreductase KS07_17890 ENOG4105DBE peroxidase KS07_17895 ENOG410650H (LipO)protein KS07_17900 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) KS07_17905 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase KS07_17910 ENOG4105CMU LysR family (Transcriptional regulator KS07_17915 ENOG4105VAW lrga family KS07_17920 ENOG41067MG lrgb family KS07_17930 ENOG4107TXC Transcriptional regulator KS07_17940 ENOG4105DR4 Methyltransferase KS07_17950 ENOG4105CK1 PTS System KS07_17955 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin KS07_17960 ENOG4105X1N Glycosyl transferase family 8 KS07_17965 ENOG4105GVJ transcriptional regulator KS07_17970 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KS07_17980 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase KS07_17990 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) KS07_17995 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein KS07_18000 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) KS07_18005 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD KS07_18010 ENOG4105CM2 brancheD-chain amino acid aminotransferase KS07_18015 ENOG4105F8D glycoside hydrolase family 4 KS07_18020 ENOG4105VCP PTS System KS07_18025 ENOG4105CK1 PTS System KS07_18030 ENOG4105VZJ PTS System KS07_18035 ENOG4105EMD TRANSCRIPTIONal KS07_18045 ENOG4105DQ5 transport system permease protein KS07_18050 ENOG4105EHG Permease protein KS07_18060 ENOG41082YX Transcriptional regulator, arsr family KS07_18065 ENOG4107R5R arsenical pump membrane protein KS07_18070 ENOG4105VZJ PTS System KS07_18075 ENOG4105VCP PTS System KS07_18080 ENOG4105CK1 PTS System KS07_18085 ENOG4105CS2 ec 3.2.1.21 KS07_18090 ENOG4105EVU fructokinase KS07_18095 ENOG4105DG6 mannose-6-phosphate isomerase KS07_18105 ENOG4105CH6 catalase KS07_18110 ENOG4107QHE Choloylglycine hydrolase KS07_18115 ENOG4105ETS cytosine purines uracil thiamine allantoin KS07_18120 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) KS07_18125 ENOG4108JJ8 (ABC) transporter KS07_18130 ENOG4108JJ9 ABC, transporter KS07_18135 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii KS07_18140 ENOG4105C4M (Ubiquinol oxidase) subunit I KS07_18145 ENOG4105D2K citrate carrier protein KS07_18150 ENOG4107BJW polysaccharide deacetylase KS07_18165 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) KS07_18175 ENOG4105CMR udp-glucose 4-epimerase KS07_18180 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KS07_18200 ENOG4105DHI Methyltransferase KS07_18225 ENOG4105CH6 catalase KS07_18230 ENOG4105D4T Citrate transporter KS07_18240 ENOG4105CID antiterminator KS07_18245 ENOG4105DEU major facilitator superfamily KS07_18250 ENOG4105C1J atp-dependent rna helicase KS07_18285 ENOG4105CNA YD repeat protein KS07_18290 ENOG4108NR7 pectate lyase KS07_18300 ENOG4107YZX Universal stress protein KS07_18310 ENOG4105M6F mutator MutT protein KS07_18315 ENOG4106Z5D Glycoside Hydrolase Family 43 KS07_18325 ENOG4105C84 Histidine ammonia-lyase KS07_18330 ENOG4105CGP Urocanate hydratase KS07_18335 ENOG4105CI2 imidazolone-5-propionate hydrolase KS07_18340 ENOG4107W25 arginase agmatinase formiminoglutamase KS07_18350 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KS07_18355 ENOG4105D9N nucleoside KS07_18360 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) KS07_18365 ENOG4107RHR regulatoR KS07_18370 ENOG410667J hydrolase KS07_18400 ENOG4108V5C ABC transporter KS07_18435 ENOG4105WZ4 isomerase KS07_18440 ENOG4105F0H myo-inositol catabolism protein KS07_18445 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KS07_18455 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) KS07_18465 ENOG4105EDK PfkB domain protein KS07_18475 ENOG4105C26 Dehydrogenase KS07_18485 ENOG4105CPC Aldo Keto reductase KS07_18490 ENOG4107QNK )-transporter KS07_18495 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) KS07_18505 ENOG41061TZ Short-chain dehydrogenase reductase Sdr KS07_18510 ENOG4108S01 response regulator KS07_18515 ENOG4108ZGX Histidine kinase KS07_18520 ENOG4105ECK Fatty Acid Desaturase KS07_18530 ENOG4105ST3 Transcriptional regulator KS07_18535 ENOG4105C26 Dehydrogenase KS07_18540 ENOG4108ITS PQQ enzyme repeat KS07_18550 ENOG4105WAB arsR family transcriptional regulator KS07_18555 ENOG4105F27 Major Facilitator KS07_18560 ENOG41085PJ rdd domain containing protein KS07_18570 ENOG4105D3R alkyl hydroperoxide reductase KS07_18575 ENOG4108JU3 Alkyl hydroperoxide reductase KS07_18580 ENOG4107R3N Filamentation induced by cAMP protein fic KS07_18585 ENOG4105C85 amino acid KS07_18590 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 KS07_18595 ENOG4108XHQ (2Fe-2S)-binding domain protein KS07_18615 ENOG4105XRQ Xanthine dehydrogenase accessory factor KS07_18640 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) KS07_18655 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) KS07_18660 ENOG4105CPC Aldo Keto reductase KS07_18665 ENOG4105WQG acetyltransferase KS07_18675 ENOG41066UZ arginase EC 3.5.3.1 KS07_18680 ENOG4108IQI permease KS07_18685 ENOG4105C8Y Acetylornithine aminotransferase KS07_18695 ENOG41082BM Transcriptional regulator, arsr family KS07_18700 ENOG4108JUB Transcriptional regulator KS07_18710 ENOG4105C5H ABC transporter KS07_18725 ENOG4105D06 uba thif-type nad fad binding protein KS07_18730 ENOG4105BZU Histidine kinase KS07_18735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS07_18740 ENOG4105C0H protease KS07_18745 ENOG4105Q2H domain protein KS07_18760 ENOG4105BZU Histidine kinase KS07_18765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KS07_18800 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase KS07_18805 ENOG4105CDU Replicative dna helicase KS07_18830 ENOG4105EDW glycosyl transferase, family 39 KS07_18845 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KS07_18850 ENOG4105CPK Glycosyl transferase (Group 1 KS07_18870 ENOG4105BZR domain protein KS07_18875 ENOG4108XMW Membrane KS07_18890 ENOG4105KVH Transcriptional regulator KS07_18895 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase KS07_18900 ENOG4108UZ3 Transporter KS07_18905 ENOG4105EDQ levansucrase EC 2.4.1.10 KS07_18910 ENOG4108HKT sucrose-6-phosphate hydrolase KS07_18940 ENOG4108TVJ Nitroreductase KS07_18945 ENOG4105FS7 Transcriptional regulator KS07_18955 ENOG4108U05 Transcriptional regulator KS07_18960 ENOG41082BV acetyltransferase KS07_18970 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase KS07_18975 ENOG4105CMU LysR family (Transcriptional regulator KS07_18980 ENOG4105DTD Dehydrogenase KS07_19010 ENOG4107Y9U Membrane KS07_19025 ENOG410847I Transcriptional regulator, BadM Rrf2 family KS07_19035 ENOG4105C7Z Conserved Protein KS07_19040 ENOG4107FCW Abortive infection protein KS07_19050 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase KS07_19060 ENOG4105CGK Exodeoxyribonuclease III KS07_19065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KS07_19075 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) KS07_19080 ENOG4108UUM single-stranded DNA-binding protein KS07_19085 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) KS07_19090 ENOG4105C3G gtp-binding protein KS07_19095 ENOG4108J2R molybdopterin oxidoreductase KS07_19100 ENOG4105VDK protein, conserved in bacteria KS07_19115 ENOG4108ZDA Sporulation protein YyaC KS07_19120 ENOG4105FA0 parb-like partition protein KS07_19125 ENOG4107QJE Chromosome Partitioning Protein KS07_19140 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) KS07_19145 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) KS07_19160 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)