locus-tag	class	description
HC662_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC662_00020	COG0592	DNA-directed DNA polymerase activity
HC662_00030	COG2501	S4 domain
HC662_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC662_00060	COG0187	DNA topoisomerase II activity
HC662_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC662_00130	COG0517	IMP dehydrogenase activity
HC662_00130	COG0516	GMP reductase activity
HC662_00140	COG1686	Belongs to the peptidase S11 family
HC662_00160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC662_00170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC662_00190	COG1428	Deoxynucleoside kinase
HC662_00200	COG1428	Deoxynucleoside kinase
HC662_00210	COG1388	LysM domain
HC662_00210	COG3858	chitin binding
HC662_00220	COG1335	isochorismatase
HC662_00230	COG0590	tRNA wobble adenosine to inosine editing
HC662_00240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC662_00250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC662_00260	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC662_00350	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HC662_00360	COG3853	Toxic anion resistance protein (TelA)
HC662_00370	COG1982	Orn Lys Arg decarboxylase major
HC662_00380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC662_00390	COG3870	Protein conserved in bacteria
HC662_00400	COG1728	Protein conserved in bacteria
HC662_00410	COG0470	DNA polymerase III
HC662_00420	COG1774	PSP1 C-terminal conserved region
HC662_00430	COG4467	Involved in initiation control of chromosome replication
HC662_00440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC662_00450	COG2827	Endonuclease containing a URI domain
HC662_00460	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC662_00470	COG2002	toxin-antitoxin pair type II binding
HC662_00480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_00480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_00490	COG0084	hydrolase, TatD family'
HC662_00500	COG3584	3D domain protein
HC662_00500	COG3583	domain protein
HC662_00510	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC662_00520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC662_00540	COG4466	Protein conserved in bacteria
HC662_00560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC662_00570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC662_00580	COG0251	oxidation-reduction process
HC662_00590	COG2088	sporulation resulting in formation of a cellular spore
HC662_00600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC662_00610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC662_00620	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC662_00630	COG0193	aminoacyl-tRNA hydrolase activity
HC662_00650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC662_00660	COG2002	toxin-antitoxin pair type II binding
HC662_00670	COG2244	polysaccharide biosynthetic process
HC662_00680	COG3956	TIGRFAM MazG family protein
HC662_00690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC662_00720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC662_00730	COG1098	S1 RNA binding domain
HC662_00760	COG2208	phosphoserine phosphatase activity
HC662_00770	COG2304	oxidoreductase activity
HC662_00780	COG0515	serine threonine protein kinase
HC662_00790	COG0037	tRNA processing
HC662_00810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC662_00820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC662_00830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC662_00840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC662_00850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC662_00860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC662_00870	COG0512	Glutamine amidotransferase of anthranilate synthase
HC662_00880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_00890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC662_00900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC662_00910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC662_00920	COG1396	sequence-specific DNA binding
HC662_00930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC662_00940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC662_01100	COG4463	regulation of RNA biosynthetic process
HC662_01110	COG3880	PFAM UvrB UvrC protein
HC662_01120	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HC662_01130	COG0542	response to heat
HC662_01140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC662_01150	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC662_01160	COG4956	integral membrane protein (PIN domain superfamily)
HC662_01170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC662_01180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC662_01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC662_01210	COG1045	serine acetyltransferase
HC662_01220	COG0215	cysteine-tRNA ligase activity
HC662_01230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC662_01240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC662_01250	COG3688	RNA-binding protein containing a PIN domain
HC662_01260	COG1595	DNA-templated transcription, initiation
HC662_01270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC662_01280	COG0250	Participates in transcription elongation, termination and antitermination
HC662_01300	COG0081	regulation of translation
HC662_01310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC662_01330	COG2813	Specifically methylates the guanine in position
HC662_01340	COG0085	RNA polymerase activity
HC662_01350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC662_01360	COG1358	cellular component organization or biogenesis
HC662_01370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC662_01380	COG0049	tRNA binding
HC662_01390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC662_01400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC662_01410	COG0596	Alpha beta hydrolase
HC662_01430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC662_01460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC662_01500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC662_01520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC662_01530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC662_01550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC662_01570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC662_01580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC662_01590	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC662_01620	COG0200	Binds to the 23S rRNA
HC662_01630	COG0201	protein transport
HC662_01640	COG0563	adenylate kinase activity
HC662_01650	COG0024	Methionine aminopeptidase
HC662_01660	COG2163	COG2163 Ribosomal protein L14E L6E L27E
HC662_01680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC662_01700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC662_01710	COG0202	RNA polymerase activity
HC662_01720	COG0203	ribosomal protein L17
HC662_01730	COG1122	ATPase activity
HC662_01740	COG1122	ATPase activity
HC662_01750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC662_01760	COG0101	tRNA pseudouridine synthase activity
HC662_01770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC662_01790	COG2226	methyltransferase
HC662_01810	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_01820	COG0489	protein tyrosine kinase activity
HC662_01840	COG2194	sulfuric ester hydrolase activity
HC662_01850	COG0726	polysaccharide deacetylase
HC662_02010	COG0738	Major facilitator superfamily
HC662_02020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC662_02040	COG1063	alcohol dehydrogenase
HC662_02050	COG0659	secondary active sulfate transmembrane transporter activity
HC662_02060	COG0385	Bile acid
HC662_02070	COG2819	hydrolase of the alpha beta superfamily
HC662_02080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_02090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_02100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_02110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_02110	COG2207	Transcriptional regulator
HC662_02120	COG3876	Protein conserved in bacteria
HC662_02130	COG1472	Belongs to the glycosyl hydrolase 3 family
HC662_02140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC662_02150	COG1263	PTS System
HC662_02150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_02160	COG1737	Transcriptional regulator
HC662_02170	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC662_02180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_02190	COG1683	Conserved Protein
HC662_02250	COG1595	DNA-templated transcription, initiation
HC662_02260	COG5662	AntiSigma factor
HC662_02270	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC662_02280	COG4856	YbbR-like protein
HC662_02290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC662_02310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC662_02330	COG2169	Transcriptional regulator
HC662_02340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC662_02350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC662_02360	COG3002	Belongs to the UPF0753 family
HC662_02370	COG0288	reversible hydration of carbon dioxide
HC662_02390	COG5609	conserved protein (DUF2294)
HC662_02400	COG0640	Transcriptional regulator
HC662_02410	COG2814	Major facilitator Superfamily
HC662_02420	COG0596	Alpha beta hydrolase
HC662_02430	COG0745	RESPONSE REGULATOR receiver
HC662_02440	COG0642	Histidine kinase
HC662_02460	COG0515	serine threonine protein kinase
HC662_02490	COG1113	amino acid transport
HC662_02520	COG2602	Beta-lactamase
HC662_02530	COG2124	cytochrome p450
HC662_02550	COG0531	amino acid
HC662_02560	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC662_02570	COG0584	glycerophosphoryl diester phosphodiesterase
HC662_02580	COG2271	Major facilitator Superfamily
HC662_02600	COG0456	acetyltransferase
HC662_02600	COG1846	Transcriptional regulator
HC662_02610	COG2271	Major facilitator Superfamily
HC662_02620	COG0697	spore germination
HC662_02630	COG2207	Transcriptional regulator
HC662_02630	COG1917	Cupin 2, conserved barrel domain protein
HC662_02640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HC662_02650	COG3591	Belongs to the peptidase S1B family
HC662_02670	COG0596	Alpha beta hydrolase
HC662_02680	COG1183	phosphatidylcholine synthase activity
HC662_02690	COG0586	Pfam SNARE associated Golgi protein
HC662_02700	COG0688	phosphatidylethanolamine metabolic process
HC662_02720	COG2312	Erythromycin esterase
HC662_02730	COG2207	Transcriptional regulator
HC662_02750	COG1301	dicarboxylic acid transport
HC662_02760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_02760	COG1263	PTS System
HC662_02760	COG2190	(PTS) system
HC662_02770	COG0363	glucosamine-6-phosphate deaminase activity
HC662_02780	COG2188	Transcriptional regulator
HC662_02800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_02810	COG0833	amino acid
HC662_02820	COG2040	homocysteine
HC662_02830	COG1115	amino acid carrier protein
HC662_02840	COG2066	Belongs to the glutaminase family
HC662_02850	COG4191	Histidine kinase
HC662_02860	COG0784	Response regulator, receiver
HC662_02870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC662_02880	COG1012	belongs to the aldehyde dehydrogenase family
HC662_02890	COG2271	Major facilitator Superfamily
HC662_02900	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_02910	COG2186	Transcriptional regulator
HC662_02920	COG2721	sulfolactate sulfo-lyase activity
HC662_02930	COG3173	Aminoglycoside phosphotransferase
HC662_02950	COG0697	spore germination
HC662_02960	COG0745	RESPONSE REGULATOR receiver
HC662_02970	COG2205	protein histidine kinase activity
HC662_02980	COG1131	(ABC) transporter
HC662_03020	COG3773	Cell wall hydrolase
HC662_03030	COG2304	oxidoreductase activity
HC662_03040	COG3540	Alkaline phosphatase
HC662_03050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC662_03060	COG0805	protein transport
HC662_03070	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC662_03080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC662_03090	COG0477	Major facilitator Superfamily
HC662_03100	COG1309	transcriptional regulator
HC662_03110	COG0252	asparaginase activity
HC662_03120	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC662_03130	COG1714	RDD family
HC662_03140	COG3012	SEC-C Motif Domain Protein
HC662_03140	COG1405	negative regulation of cell septum assembly
HC662_03150	COG3290	protein histidine kinase activity
HC662_03160	COG3279	Response regulator of the LytR AlgR family
HC662_03170	COG4555	ABC transporter
HC662_03180	COG1668	transmembrane transport
HC662_03190	COG0667	Aldo Keto reductase
HC662_03210	COG1595	DNA-templated transcription, initiation
HC662_03220	COG1595	DNA-templated transcription, initiation
HC662_03230	COG1876	peptidase activity
HC662_03240	COG0457	Tetratricopeptide repeat
HC662_03250	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_03260	COG0366	Alpha amylase catalytic
HC662_03270	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC662_03280	COG1121	(ABC) transporter
HC662_03290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC662_03300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_03310	COG2310	stress, protein
HC662_03320	COG2310	stress, protein
HC662_03330	COG2310	stress, protein
HC662_03340	COG0861	Integral membrane protein TerC family
HC662_03360	COG3853	Toxic anion resistance protein (TelA)
HC662_03370	COG0477	Major facilitator Superfamily
HC662_03380	COG2814	Major facilitator Superfamily
HC662_03390	COG0640	Transcriptional regulator
HC662_03400	COG0517	IMP dehydrogenase activity
HC662_03400	COG4175	Glycine betaine
HC662_03410	COG4176	ABC-type proline glycine betaine transport system permease component
HC662_03420	COG2113	Glycine betaine
HC662_03430	COG1473	amidohydrolase
HC662_03440	COG1288	antiporter activity
HC662_03460	COG0366	Alpha amylase catalytic
HC662_03470	COG0039	L-malate dehydrogenase activity
HC662_03480	COG1620	l-lactate permease
HC662_03490	COG2814	Major facilitator Superfamily
HC662_03500	COG1846	Transcriptional regulator
HC662_03510	COG1280	lysine exporter protein (LysE YggA)
HC662_03520	COG3403	YqcI/YcgG family
HC662_03530	COG1113	amino acid transport
HC662_03540	COG3665	Urea carboxylase-associated protein
HC662_03550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC662_03560	COG1660	Displays ATPase and GTPase activities
HC662_03570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC662_03580	COG2226	methyltransferase
HC662_03590	COG0583	DNA-binding transcription factor activity
HC662_03600	COG3458	cephalosporin-C deacetylase activity
HC662_03610	COG3541	Predicted nucleotidyltransferase
HC662_03620	COG0506	proline dehydrogenase activity
HC662_03630	COG1012	belongs to the aldehyde dehydrogenase family
HC662_03640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_03650	COG2508	Transcriptional regulator
HC662_03660	COG3689	TIGRFAM TIGR03943 family protein
HC662_03670	COG0701	Predicted permease
HC662_03680	COG2267	carboxylic ester hydrolase activity
HC662_03690	COG0492	ferredoxin-NADP+ reductase activity
HC662_03700	COG1587	Uroporphyrinogen-III synthase
HC662_03700	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC662_03710	COG2146	nitrite reductase [NAD(P)H] activity
HC662_03720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC662_03730	COG0243	molybdopterin cofactor binding
HC662_03740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC662_03750	COG2223	nitrite transmembrane transporter activity
HC662_03760	COG1469	GTP cyclohydrolase I activity
HC662_03770	COG1376	ErfK ybiS ycfS ynhG family protein
HC662_03790	COG0523	cobalamin synthesis protein
HC662_03800	COG0765	amino acid transport
HC662_03810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_03820	COG1714	RDD family
HC662_03840	COG2723	6-phospho-beta-galactosidase activity
HC662_03860	COG3209	COG3209 Rhs family protein
HC662_03870	COG0840	transmembrane signaling receptor activity
HC662_03870	COG3290	protein histidine kinase activity
HC662_03880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC662_03890	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC662_03900	COG1733	regulation of RNA biosynthetic process
HC662_03910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_03920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_03930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_03940	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC662_03950	COG2814	Major facilitator Superfamily
HC662_03970	COG0697	spore germination
HC662_03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_04000	COG2364	Membrane
HC662_04010	COG1126	abc transporter atp-binding protein
HC662_04020	COG0765	amino acid transport
HC662_04030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_04040	COG0583	DNA-binding transcription factor activity
HC662_04050	COG0163	prenyltransferase activity
HC662_04060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC662_04080	COG0596	Alpha beta hydrolase
HC662_04090	COG3104	oligopeptide transport
HC662_04100	COG5434	Belongs to the glycosyl hydrolase 28 family
HC662_04120	COG0697	spore germination
HC662_04140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC662_04150	COG1136	(ABC) transporter
HC662_04160	COG0577	efflux transmembrane transporter activity
HC662_04170	COG0745	RESPONSE REGULATOR receiver
HC662_04180	COG3850	Histidine kinase
HC662_04180	COG5002	protein histidine kinase activity
HC662_04190	COG0457	Tetratricopeptide repeat
HC662_04210	COG0527	aspartate kinase activity
HC662_04220	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_04230	COG4605	iron ion homeostasis
HC662_04240	COG4604	ABC transporter, ATP-binding protein
HC662_04250	COG4607	ABC-type enterochelin transport system periplasmic component
HC662_04260	COG2814	Major facilitator Superfamily
HC662_04270	COG1309	transcriptional regulator
HC662_04280	COG0778	Nitroreductase
HC662_04290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC662_04300	COG0640	Transcriptional regulator
HC662_04310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_04320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC662_04330	COG1012	belongs to the aldehyde dehydrogenase family
HC662_04340	COG4975	Glucose uptake
HC662_04350	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_04360	COG4549	nuclear export factor GLE1
HC662_04370	COG1276	copper resistance
HC662_04370	COG2372	response to copper ion
HC662_04380	COG1349	DNA-binding transcription factor activity
HC662_04400	COG2213	PTS system mannitol-specific
HC662_04410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_04420	COG0246	Mannitol dehydrogenase
HC662_04430	COG0473	3-isopropylmalate dehydrogenase activity
HC662_04440	COG0412	Dienelactone hydrolase
HC662_04450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC662_04470	COG0561	phosphatase activity
HC662_04480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC662_04490	COG1914	H( )-stimulated, divalent metal cation uptake system
HC662_04500	COG4336	lyase activity
HC662_04510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC662_04520	COG1984	allophanate hydrolase subunit 2
HC662_04530	COG1414	Transcriptional regulator
HC662_04540	COG2755	lipolytic protein G-D-S-L family
HC662_04560	COG2329	Antibiotic biosynthesis monooxygenase
HC662_04570	COG0768	penicillin binding
HC662_04580	COG4989	oxidoreductase activity
HC662_04590	COG3711	transcriptional antiterminator
HC662_04600	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_04610	COG2226	methyltransferase
HC662_04620	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_04630	COG1917	Cupin 2, conserved barrel domain protein
HC662_04640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_04650	COG3871	stress protein (general stress protein 26)
HC662_04670	COG2814	Major facilitator Superfamily
HC662_04680	COG1522	sequence-specific DNA binding
HC662_04690	COG0551	DNA topoisomerase type I activity
HC662_04690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC662_04700	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC662_04710	COG3706	GGDEF domain
HC662_04720	COG5298	Protein conserved in bacteria
HC662_04730	COG1215	transferase activity, transferring glycosyl groups
HC662_04750	COG0531	amino acid
HC662_04760	COG0494	nUDIX hydrolase
HC662_04770	COG0028	Belongs to the TPP enzyme family
HC662_04790	COG1914	H( )-stimulated, divalent metal cation uptake system
HC662_04800	COG2261	transglycosylase associated protein
HC662_04810	COG4876	unkown
HC662_04820	COG2217	Heavy metal translocating P-type atpase
HC662_04830	COG3729	General stress protein
HC662_04840	COG0662	Cupin 2, conserved barrel domain protein
HC662_04850	COG2329	Antibiotic biosynthesis monooxygenase
HC662_04860	COG3546	catalase activity
HC662_04870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC662_04880	COG3290	protein histidine kinase activity
HC662_04890	COG4565	transcriptional regulatory protein
HC662_04900	COG1301	dicarboxylic acid transport
HC662_04910	COG0628	permease
HC662_04920	COG1301	dicarboxylic acid transport
HC662_04930	COG1131	(ABC) transporter
HC662_04940	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC662_04960	COG1960	acyl-CoA dehydrogenase activity
HC662_04990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC662_05000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_05010	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC662_05020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC662_05030	COG0513	Belongs to the DEAD box helicase family
HC662_05040	COG3402	PFAM membrane-flanked domain
HC662_05050	COG3428	Bacterial PH domain
HC662_05060	COG0705	Rhomboid family
HC662_05070	COG0736	holo-[acyl-carrier-protein] synthase activity
HC662_05080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC662_05090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC662_05100	COG0864	Transcriptional regulator
HC662_05110	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC662_05120	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_05130	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_05140	COG2172	sigma factor antagonist activity
HC662_05150	COG2208	phosphoserine phosphatase activity
HC662_05160	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_05170	COG2172	sigma factor antagonist activity
HC662_05180	COG1191	sigma factor activity
HC662_05190	COG2208	phosphoserine phosphatase activity
HC662_05200	COG2183	response to ionizing radiation
HC662_05210	COG3091	SprT-like family
HC662_05290	COG0582	viral genome integration into host DNA
HC662_05300	COG2856	Zn peptidase
HC662_05310	COG1396	sequence-specific DNA binding
HC662_05360	COG1674	ftsk spoiiie
HC662_05370	COG2946	Replication initiation factor
HC662_05450	COG0433	COG0433 Predicted ATPase
HC662_05470	COG5644	endopeptidase inhibitor activity
HC662_05480	COG0741	lytic transglycosylase activity
HC662_05480	COG0791	NLP P60 protein
HC662_05540	COG5444	nuclease activity
HC662_05550	COG0457	Tetratricopeptide repeat
HC662_05570	COG1278	Cold shock
HC662_05580	COG1329	Transcriptional regulator
HC662_05590	COG3708	Transcriptional regulator
HC662_05590	COG2207	Transcriptional regulator
HC662_05610	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HC662_05620	COG2814	Major facilitator Superfamily
HC662_05630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_05640	COG1309	transcriptional regulator
HC662_05650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC662_05660	COG1522	sequence-specific DNA binding
HC662_05690	COG0697	spore germination
HC662_05700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_05710	COG2030	dehydratase
HC662_05720	COG3545	Serine hydrolase
HC662_05730	COG1733	regulation of RNA biosynthetic process
HC662_05740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_05750	COG1733	regulation of RNA biosynthetic process
HC662_05760	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC662_05770	COG2814	Major facilitator Superfamily
HC662_05780	COG1309	transcriptional regulator
HC662_05810	COG0640	Transcriptional regulator
HC662_05820	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC662_05830	COG0640	Transcriptional regulator
HC662_05840	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC662_05850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC662_05860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_05870	COG1316	TRANSCRIPTIONal
HC662_05890	COG5002	protein histidine kinase activity
HC662_05890	COG3850	Histidine kinase
HC662_05900	COG0745	RESPONSE REGULATOR receiver
HC662_05910	COG0697	spore germination
HC662_05920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_05930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC662_05940	COG0640	Transcriptional regulator
HC662_05950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC662_05980	COG4585	Histidine kinase
HC662_05990	COG2197	response regulator
HC662_06000	COG2409	Drug exporters of the RND superfamily
HC662_06010	COG1811	Na channel or pump
HC662_06020	COG4978	Transcriptional regulator
HC662_06020	COG0789	Transcriptional regulator
HC662_06030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC662_06040	COG0778	Nitroreductase
HC662_06050	COG0346	lactoylglutathione lyase activity
HC662_06060	COG2259	Doxx family
HC662_06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_06080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_06100	COG1309	transcriptional regulator
HC662_06120	COG0456	acetyltransferase
HC662_06140	COG1113	amino acid transport
HC662_06150	COG2318	DinB family
HC662_06160	COG1846	Transcriptional regulator
HC662_06170	COG2409	Drug exporters of the RND superfamily
HC662_06170	COG1033	growth of symbiont in host cell
HC662_06190	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_06200	COG0778	Nitroreductase
HC662_06210	COG1846	Transcriptional regulator
HC662_06220	COG1396	sequence-specific DNA binding
HC662_06250	COG2814	Major facilitator Superfamily
HC662_06260	COG0730	response to heat
HC662_06270	COG1802	Transcriptional regulator
HC662_06280	COG1388	LysM domain
HC662_06280	COG3858	chitin binding
HC662_06290	COG1819	glycosyl
HC662_06310	COG1785	Belongs to the alkaline phosphatase family
HC662_06320	COG5646	InterPro IPR014922
HC662_06330	COG0454	-acetyltransferase
HC662_06340	COG1078	dGTPase activity
HC662_06350	COG1388	LysM domain
HC662_06360	COG2814	Major facilitator Superfamily
HC662_06370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_06380	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC662_06390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_06400	COG2723	6-phospho-beta-galactosidase activity
HC662_06410	COG2188	Transcriptional regulator
HC662_06420	COG1940	carbohydrate kinase activity
HC662_06430	COG1482	cell wall glycoprotein biosynthetic process
HC662_06440	COG4124	Belongs to the glycosyl hydrolase 26 family
HC662_06530	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HC662_06540	COG0802	atpase or kinase
HC662_06550	COG1214	PFAM Peptidase M22, glycoprotease
HC662_06560	COG0456	acetyltransferase
HC662_06570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC662_06580	COG0488	(ABC) transporter
HC662_06590	COG0315	cyclic pyranopterin monophosphate synthase activity
HC662_06600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC662_06610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC662_06620	COG0805	protein transport
HC662_06640	COG1266	CAAX protease self-immunity
HC662_06660	COG0459	protein refolding
HC662_06680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC662_06690	COG0457	Tetratricopeptide repeat
HC662_06700	COG1063	alcohol dehydrogenase
HC662_06710	COG2211	Major facilitator Superfamily
HC662_06720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_06740	COG2814	Major facilitator Superfamily
HC662_06750	COG1063	alcohol dehydrogenase
HC662_06760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC662_06770	COG0823	Involved in the tonB-independent uptake of proteins
HC662_06800	COG2267	carboxylic ester hydrolase activity
HC662_06820	COG2132	Multicopper oxidase
HC662_06830	COG1113	amino acid transport
HC662_06840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC662_06850	COG0714	Associated with various cellular activities
HC662_06860	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HC662_06870	COG1305	Transglutaminase-like
HC662_06880	COG0519	Catalyzes the synthesis of GMP from XMP
HC662_06880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC662_06900	COG1674	ftsk spoiiie
HC662_06960	COG2252	PERMEase
HC662_06970	COG3064	Membrane
HC662_06990	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HC662_07010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC662_07020	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC662_07030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC662_07040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC662_07050	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC662_07060	COG0047	phosphoribosylformylglycinamidine synthase activity
HC662_07070	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC662_07080	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC662_07090	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC662_07100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC662_07110	COG0138	bifunctional purine biosynthesis protein purh
HC662_07120	COG0151	Belongs to the GarS family
HC662_07130	COG1522	sequence-specific DNA binding
HC662_07140	COG0531	amino acid
HC662_07160	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC662_07170	COG1470	cell adhesion involved in biofilm formation
HC662_07180	COG4496	protein, YerC YecD
HC662_07190	COG0069	glutamate synthase activity
HC662_07200	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HC662_07210	COG0210	DNA helicase
HC662_07220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC662_07230	COG4851	CamS sex pheromone cAM373 precursor
HC662_07240	COG2814	Major facilitator Superfamily
HC662_07260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC662_07280	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC662_07290	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC662_07390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC662_07400	COG1785	Belongs to the alkaline phosphatase family
HC662_07410	COG1285	pathogenesis
HC662_07420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_07430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC662_07440	COG0154	amidase activity
HC662_07450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC662_07460	COG1309	transcriptional regulator
HC662_07470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC662_07480	COG1597	lipid kinase activity
HC662_07490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC662_07510	COG0457	Tetratricopeptide repeat
HC662_07540	COG5444	nuclease activity
HC662_07550	COG3391	amine dehydrogenase activity
HC662_07570	COG0457	Tetratricopeptide repeat
HC662_07590	COG0217	transcriptional regulatory protein
HC662_07610	COG1309	transcriptional regulator
HC662_07620	COG3631	Ketosteroid isomerase-related protein
HC662_07630	COG0702	epimerase
HC662_07660	COG3546	catalase activity
HC662_07670	COG0454	-acetyltransferase
HC662_07690	COG5578	integral membrane protein
HC662_07700	COG2972	Histidine kinase
HC662_07710	COG4753	response regulator
HC662_07710	COG2207	Transcriptional regulator
HC662_07720	COG1653	transport
HC662_07730	COG1175	transmembrane transport
HC662_07740	COG0395	ABC-type sugar transport system, permease component
HC662_07750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC662_07760	COG2207	Transcriptional regulator
HC662_07770	COG2755	lipolytic protein G-D-S-L family
HC662_07790	COG5578	integral membrane protein
HC662_07800	COG3401	FG-GAP repeat protein
HC662_07810	COG3401	FG-GAP repeat protein
HC662_07820	COG0667	Aldo Keto reductase
HC662_07830	COG2755	lipolytic protein G-D-S-L family
HC662_07840	COG1874	Beta-galactosidase
HC662_07860	COG1653	transport
HC662_07870	COG4209	transmembrane transport
HC662_07880	COG0395	ABC-type sugar transport system, permease component
HC662_07890	COG1486	melibiose metabolic process
HC662_07900	COG2323	membrane
HC662_07910	COG2329	Antibiotic biosynthesis monooxygenase
HC662_07920	COG0346	lactoylglutathione lyase activity
HC662_07950	COG5583	Uncharacterized small protein (DUF2292)
HC662_07960	COG0670	Belongs to the BI1 family
HC662_07970	COG0697	spore germination
HC662_07980	COG1846	Transcriptional regulator
HC662_07990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC662_08040	COG2124	cytochrome p450
HC662_08040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC662_08050	COG1368	sulfuric ester hydrolase activity
HC662_08070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC662_08080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_08090	COG1442	glycosyl transferase family 8
HC662_08100	COG1216	Glycosyl transferase, family 2
HC662_08110	COG1442	glycosyl transferase family 8
HC662_08120	COG2223	nitrite transmembrane transporter activity
HC662_08130	COG1011	Hydrolase
HC662_08140	COG0531	amino acid
HC662_08150	COG1012	belongs to the aldehyde dehydrogenase family
HC662_08160	COG0840	transmembrane signaling receptor activity
HC662_08170	COG0488	(ABC) transporter
HC662_08190	COG0789	Transcriptional regulator
HC662_08200	COG2814	Major facilitator Superfamily
HC662_08230	COG0488	(ABC) transporter
HC662_08240	COG0513	Belongs to the DEAD box helicase family
HC662_08250	COG0456	acetyltransferase
HC662_08260	COG2130	NADP-dependent
HC662_08270	COG1120	ATPase activity
HC662_08280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_08290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_08300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC662_08330	COG3866	Pectate lyase
HC662_08340	COG0471	metal ion transport
HC662_08350	COG3290	protein histidine kinase activity
HC662_08360	COG4565	transcriptional regulatory protein
HC662_08370	COG3181	Tripartite tricarboxylate transporter family receptor
HC662_08390	COG2851	Citrate transporter
HC662_08400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_08410	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HC662_08420	COG1254	Belongs to the acylphosphatase family
HC662_08430	COG2258	MOSC domain
HC662_08470	COG0024	Methionine aminopeptidase
HC662_08480	COG1263	PTS System
HC662_08480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_08490	COG1368	sulfuric ester hydrolase activity
HC662_08510	COG1115	amino acid carrier protein
HC662_08520	COG0697	spore germination
HC662_08530	COG1263	PTS System
HC662_08530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_08540	COG0366	Alpha amylase catalytic
HC662_08550	COG2188	Transcriptional regulator
HC662_08560	COG0778	Nitroreductase
HC662_08570	COG0737	Belongs to the 5'-nucleotidase family
HC662_08580	COG0693	protein deglycase activity
HC662_08590	COG2814	Major facilitator Superfamily
HC662_08600	COG4840	Belongs to the UPF0435 family
HC662_08610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC662_08620	COG4980	gas vesicle protein
HC662_08630	COG1295	ribonuclease BN
HC662_08640	COG0477	Major facilitator Superfamily
HC662_08650	COG0387	Pfam Sodium calcium exchanger
HC662_08670	COG0668	transmembrane transport
HC662_08680	COG0535	radical SAM domain protein
HC662_08700	COG0726	polysaccharide deacetylase
HC662_08710	COG2084	Dehydrogenase
HC662_08720	COG0598	Magnesium transport protein CorA
HC662_08730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC662_08740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC662_08750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC662_08770	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HC662_08790	COG4637	Psort location Cytoplasmic, score
HC662_08810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC662_08820	COG0022	dehydrogenase e1 component
HC662_08830	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC662_08840	COG1132	(ABC) transporter
HC662_08850	COG2259	Doxx family
HC662_08860	COG2514	catechol 2,3-dioxygenase activity
HC662_08870	COG4585	Histidine kinase
HC662_08880	COG2197	response regulator
HC662_08890	COG1131	(ABC) transporter
HC662_08900	COG0842	Transport permease protein
HC662_08900	COG1511	domain protein
HC662_08910	COG0842	Transport permease protein
HC662_08930	COG1695	Transcriptional regulator
HC662_08940	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC662_08980	COG1131	(ABC) transporter
HC662_08990	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HC662_09000	COG1309	transcriptional regulator
HC662_09010	COG2814	Major facilitator Superfamily
HC662_09020	COG2318	DinB family
HC662_09030	COG2814	Major facilitator Superfamily
HC662_09040	COG1846	Transcriptional regulator
HC662_09050	COG0392	lysyltransferase activity
HC662_09050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC662_09060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_09070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_09080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_09090	COG0384	phenazine biosynthesis protein PhzF
HC662_09100	COG0778	Nitroreductase
HC662_09130	COG1090	epimerase
HC662_09140	COG2137	regulation of response to DNA damage stimulus
HC662_09160	COG2814	Major facilitator Superfamily
HC662_09190	COG3103	Sh3 type 3 domain protein
HC662_09200	COG5658	integral membrane protein
HC662_09210	COG0596	Alpha beta hydrolase
HC662_09220	COG0463	Glycosyl transferase, family 2
HC662_09230	COG4485	Bacterial membrane protein, YfhO
HC662_09240	COG1988	membrane-bound metal-dependent
HC662_09250	COG1194	a g-specific adenine glycosylase
HC662_09270	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_09300	COG3557	Belongs to the UPF0374 family
HC662_09310	COG1132	(ABC) transporter
HC662_09320	COG4129	membrane
HC662_09330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC662_09340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC662_09350	COG0735	belongs to the Fur family
HC662_09590	COG0534	Mate efflux family protein
HC662_09600	COG2070	2-Nitropropane dioxygenase
HC662_09600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC662_09610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_09620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_09630	COG2226	methyltransferase
HC662_09640	COG0534	Mate efflux family protein
HC662_09830	COG0735	belongs to the Fur family
HC662_09840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC662_09850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC662_09860	COG4129	membrane
HC662_09870	COG1132	(ABC) transporter
HC662_09880	COG3557	Belongs to the UPF0374 family
HC662_09910	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_09920	COG4221	oxidoreductase activity
HC662_09920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_09920	COG0300	oxidoreductase activity
HC662_09920	COG3321	synthase
HC662_09930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_09930	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_09930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_09930	COG3321	synthase
HC662_09940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_09940	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_09940	COG3321	synthase
HC662_09940	COG0300	oxidoreductase activity
HC662_09940	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_09950	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_09950	COG3321	synthase
HC662_09950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_09950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_09950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_09960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_09960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_09960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_09960	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_09960	COG3321	synthase
HC662_09970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC662_09980	COG3425	synthase
HC662_09990	COG1024	Enoyl-CoA hydratase
HC662_10000	COG1024	Enoyl-CoA hydratase
HC662_10010	COG1024	Enoyl-CoA hydratase
HC662_10030	COG1819	glycosyl
HC662_10080	COG4326	sporulation control protein
HC662_10100	COG5577	PFAM Coat F domain
HC662_10110	COG3340	Belongs to the peptidase S51 family
HC662_10120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC662_10140	COG0753	catalase activity
HC662_10150	COG1116	anion transmembrane transporter activity
HC662_10160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC662_10170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC662_10180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_10200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC662_10220	COG1476	TRANSCRIPTIONal
HC662_10240	COG3382	B3 4 domain protein
HC662_10250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC662_10270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC662_10280	COG0789	Transcriptional regulator
HC662_10290	COG1664	Polymer-forming cytoskeletal
HC662_10300	COG1664	Polymer-forming cytoskeletal
HC662_10320	COG2766	serine protein kinase
HC662_10330	COG2718	Belongs to the UPF0229 family
HC662_10340	COG1846	Transcriptional regulator
HC662_10350	COG1566	PFAM secretion protein HlyD family protein
HC662_10360	COG2814	Major facilitator Superfamily
HC662_10370	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC662_10400	COG1725	Transcriptional regulator
HC662_10410	COG1131	(ABC) transporter
HC662_10420	COG1131	(ABC) transporter
HC662_10430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC662_10440	COG1278	Cold shock
HC662_10450	COG1464	Belongs to the NlpA lipoprotein family
HC662_10460	COG3706	GGDEF domain
HC662_10470	COG1823	symporter activity
HC662_10480	COG0456	acetyltransferase
HC662_10530	COG5577	PFAM Coat F domain
HC662_10540	COG3764	Sortase (surface protein transpeptidase)
HC662_10550	COG0564	pseudouridine synthase activity
HC662_10570	COG0517	IMP dehydrogenase activity
HC662_10580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC662_10590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC662_10590	COG3153	acetyltransferase
HC662_10610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC662_10620	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HC662_10630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC662_10640	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC662_10650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC662_10660	COG4585	Histidine kinase
HC662_10660	COG2203	Gaf domain
HC662_10670	COG2197	response regulator
HC662_10680	COG0431	NADPH-dependent FMN reductase
HC662_10710	COG0791	NLP P60 protein
HC662_10710	COG1388	LysM domain
HC662_10730	COG1959	2 iron, 2 sulfur cluster binding
HC662_10740	COG0668	transmembrane transport
HC662_10750	COG2719	SpoVR family
HC662_10760	COG1785	Belongs to the alkaline phosphatase family
HC662_10770	COG0791	NLP P60 protein
HC662_10770	COG1388	LysM domain
HC662_10780	COG0583	DNA-binding transcription factor activity
HC662_10790	COG0372	Belongs to the citrate synthase family
HC662_10800	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_10810	COG0531	amino acid
HC662_10820	COG0733	neurotransmitter:sodium symporter activity
HC662_10830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_10840	COG0456	acetyltransferase
HC662_10870	COG1595	DNA-templated transcription, initiation
HC662_10880	COG0667	Aldo Keto reductase
HC662_10890	COG0204	Acyl-transferase
HC662_10900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_10910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_10920	COG1253	flavin adenine dinucleotide binding
HC662_10930	COG0789	Transcriptional regulator
HC662_10940	COG0436	Aminotransferase
HC662_10950	COG1253	flavin adenine dinucleotide binding
HC662_10960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC662_10970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC662_10980	COG0584	glycerophosphoryl diester phosphodiesterase
HC662_11000	COG0668	transmembrane transport
HC662_11010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC662_11020	COG0726	polysaccharide deacetylase
HC662_11030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_11040	COG1757	Na H antiporter
HC662_11050	COG0589	response to stress
HC662_11070	COG1132	(ABC) transporter
HC662_11080	COG1132	(ABC) transporter
HC662_11090	COG0702	epimerase
HC662_11120	COG0189	ligase activity
HC662_11130	COG0189	ligase activity
HC662_11140	COG4399	Belongs to the UPF0754 family
HC662_11150	COG3679	Belongs to the UPF0342 family
HC662_11160	COG4335	DNA alkylation repair
HC662_11170	COG0561	phosphatase activity
HC662_11180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC662_11190	COG0475	glutathione-regulated potassium exporter activity
HC662_11200	COG0490	domain, Protein
HC662_11220	COG1024	Enoyl-CoA hydratase
HC662_11240	COG4152	abc transporter atp-binding protein
HC662_11250	COG1668	transmembrane transport
HC662_11260	COG0420	3'-5' exonuclease activity
HC662_11270	COG4717	serine-type aminopeptidase activity
HC662_11280	COG3481	metal-dependent phosphohydrolase, HD sub domain
HC662_11300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC662_11330	COG1846	Transcriptional regulator
HC662_11340	COG4980	gas vesicle protein
HC662_11370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC662_11380	COG0537	adenosine 5'-monophosphoramidase activity
HC662_11390	COG1131	(ABC) transporter
HC662_11400	COG4473	ABC transporter
HC662_11420	COG1473	amidohydrolase
HC662_11430	COG3069	C4-dicarboxylate transmembrane transporter activity
HC662_11450	COG2329	Antibiotic biosynthesis monooxygenase
HC662_11460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC662_11470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC662_11500	COG1309	transcriptional regulator
HC662_11510	COG1511	domain protein
HC662_11520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC662_11530	COG4377	Putative membrane peptidase family (DUF2324)
HC662_11550	COG1363	Peptidase, m42
HC662_11560	COG4405	Protein conserved in bacteria
HC662_11570	COG1301	dicarboxylic acid transport
HC662_11590	COG1234	tRNA 3'-trailer cleavage
HC662_11600	COG0095	Lipoate-protein ligase
HC662_11610	COG0702	epimerase
HC662_11620	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_11640	COG0501	Belongs to the peptidase M48B family
HC662_11650	COG1404	Belongs to the peptidase S8 family
HC662_11670	COG0456	acetyltransferase
HC662_11680	COG0604	alcohol dehydrogenase
HC662_11690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC662_11700	COG0406	alpha-ribazole phosphatase activity
HC662_11710	COG0183	Belongs to the thiolase family
HC662_11720	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_11730	COG1268	BioY protein
HC662_11740	COG0840	transmembrane signaling receptor activity
HC662_11750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_11750	COG0723	plastoquinol--plastocyanin reductase activity
HC662_11760	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_11780	COG4903	ComK protein
HC662_11790	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_11810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_11840	COG0398	Pfam SNARE associated Golgi protein
HC662_11850	COG0681	Belongs to the peptidase S26 family
HC662_11860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC662_11870	COG1846	Transcriptional regulator
HC662_11880	COG3180	Ammonia monooxygenase
HC662_11890	COG2814	Major facilitator Superfamily
HC662_11890	COG0477	Major facilitator Superfamily
HC662_11900	COG4533	DNA binding
HC662_11920	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC662_11930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC662_11940	COG1074	ATP-dependent DNA helicase activity
HC662_11950	COG0420	3'-5' exonuclease activity
HC662_11960	COG0419	ATPase involved in DNA repair
HC662_11970	COG1403	HNH endonuclease
HC662_12050	COG5337	Spore coat protein CotH
HC662_12060	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC662_12080	COG1404	Belongs to the peptidase S8 family
HC662_12100	COG0367	asparagine synthase
HC662_12110	COG1562	ergosterol biosynthetic process
HC662_12120	COG0534	Mate efflux family protein
HC662_12130	COG2207	Transcriptional regulator
HC662_12130	COG1917	Cupin 2, conserved barrel domain protein
HC662_12140	COG1609	Transcriptional regulator
HC662_12150	COG0673	inositol 2-dehydrogenase activity
HC662_12160	COG2318	DinB family
HC662_12170	COG1279	arginine transmembrane transporter activity
HC662_12180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_12190	COG1357	PFAM Pentapeptide repeats (8 copies)
HC662_12200	COG2267	carboxylic ester hydrolase activity
HC662_12210	COG0529	Catalyzes the synthesis of activated sulfate
HC662_12220	COG2046	Belongs to the sulfate adenylyltransferase family
HC662_12230	COG0175	sulfate reduction
HC662_12240	COG2045	Belongs to the ComB family
HC662_12250	COG1809	phosphosulfolactate synthase activity
HC662_12260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_12270	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_12280	COG2814	Major facilitator Superfamily
HC662_12290	COG0454	-acetyltransferase
HC662_12300	COG2153	protein acetylation
HC662_12310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC662_12310	COG0646	methionine synthase
HC662_12320	COG1666	GTP binding
HC662_12330	COG2996	Protein conserved in bacteria
HC662_12370	COG1695	Transcriptional regulator
HC662_12400	COG3227	Zinc metalloprotease (Elastase)
HC662_12410	COG1307	EDD domain protein, DegV family
HC662_12420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_12450	COG0561	phosphatase activity
HC662_12460	COG1073	alpha beta
HC662_12470	COG2151	metal-sulfur cluster biosynthetic enzyme
HC662_12490	COG0277	FAD linked oxidase domain protein
HC662_12500	COG2271	Major facilitator Superfamily
HC662_12510	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC662_12520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC662_12540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC662_12550	COG0505	Belongs to the CarA family
HC662_12560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC662_12570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC662_12600	COG2267	carboxylic ester hydrolase activity
HC662_12620	COG1744	ABC transporter substrate-binding protein PnrA-like
HC662_12650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC662_12660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC662_12670	COG5504	Zn-dependent protease
HC662_12680	COG0444	Belongs to the ABC transporter superfamily
HC662_12690	COG4608	Belongs to the ABC transporter superfamily
HC662_12710	COG0601	transmembrane transport
HC662_12720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_12740	COG0180	Tryptophanyl-tRNA synthetase
HC662_12750	COG4166	transmembrane transport
HC662_12760	COG0601	transmembrane transport
HC662_12770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_12780	COG0444	Belongs to the ABC transporter superfamily
HC662_12790	COG4608	Belongs to the ABC transporter superfamily
HC662_12800	COG2814	Major facilitator Superfamily
HC662_12810	COG0456	acetyltransferase
HC662_12820	COG1393	Belongs to the ArsC family
HC662_12830	COG0861	Integral membrane protein TerC family
HC662_12840	COG4862	establishment of competence for transformation
HC662_12850	COG4469	Competence protein
HC662_12860	COG1164	Oligoendopeptidase f
HC662_12890	COG2346	COG2346, Truncated hemoglobins
HC662_12900	COG0741	lytic transglycosylase activity
HC662_12910	COG4116	CYTH
HC662_12930	COG2357	RelA SpoT domain protein
HC662_12940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC662_12950	COG0564	pseudouridine synthase activity
HC662_12960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC662_12970	COG0569	domain protein
HC662_12970	COG0475	glutathione-regulated potassium exporter activity
HC662_12980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC662_12990	COG0352	thiamine-phosphate diphosphorylase activity
HC662_13000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_13010	COG2104	thiamine diphosphate biosynthetic process
HC662_13020	COG2022	thiamine diphosphate biosynthetic process
HC662_13030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC662_13040	COG0351	phosphomethylpyrimidine kinase
HC662_13050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC662_13160	COG0210	DNA helicase
HC662_13180	COG2153	protein acetylation
HC662_13190	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC662_13200	COG2382	esterase
HC662_13210	COG0626	cystathionine gamma-synthase activity
HC662_13220	COG0626	cystathionine gamma-synthase activity
HC662_13230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_13240	COG5505	Protein of unknown function (DUF819)
HC662_13260	COG0582	viral genome integration into host DNA
HC662_13290	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC662_13300	COG1404	Belongs to the peptidase S8 family
HC662_13310	COG1595	DNA-templated transcription, initiation
HC662_13330	COG4824	toxin secretion phage lysis holin
HC662_13340	COG1388	LysM domain
HC662_13340	COG3409	Peptidoglycan-binding domain 1 protein
HC662_13340	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_13350	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_13350	COG3409	Peptidoglycan-binding domain 1 protein
HC662_13390	COG5444	nuclease activity
HC662_13440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC662_13460	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC662_13470	COG3711	transcriptional antiterminator
HC662_13470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_13480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_13480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_13480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_13490	COG1482	cell wall glycoprotein biosynthetic process
HC662_13520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_13540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC662_13560	COG0109	protoheme IX farnesyltransferase activity
HC662_13580	COG0726	polysaccharide deacetylase
HC662_13610	COG5504	Zn-dependent protease
HC662_13620	COG2205	protein histidine kinase activity
HC662_13640	COG3383	formate dehydrogenase (NAD+) activity
HC662_13650	COG2427	Protein of unknown function (DUF1641)
HC662_13670	COG1051	belongs to the nudix hydrolase family
HC662_13690	COG2124	cytochrome p450
HC662_13700	COG1819	glycosyl
HC662_13720	COG1587	Uroporphyrinogen-III synthase
HC662_13740	COG0697	spore germination
HC662_13750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC662_13770	COG0473	3-isopropylmalate dehydrogenase activity
HC662_13770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HC662_13800	COG0390	transport system, permease component
HC662_13810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC662_13820	COG0697	spore germination
HC662_13830	COG4297	protein containing double-stranded beta helix domain
HC662_13850	COG1252	NADH dehydrogenase
HC662_13860	COG1904	glucuronate isomerase
HC662_13870	COG2211	Major facilitator Superfamily
HC662_13880	COG1063	alcohol dehydrogenase
HC662_13890	COG1312	Catalyzes the dehydration of D-mannonate
HC662_13900	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_13910	COG2271	Major facilitator Superfamily
HC662_13920	COG1609	Transcriptional regulator
HC662_13930	COG0246	Mannitol dehydrogenase
HC662_13940	COG2721	sulfolactate sulfo-lyase activity
HC662_13950	COG0730	response to heat
HC662_13960	COG2318	DinB family
HC662_13970	COG0457	Tetratricopeptide repeat
HC662_13990	COG2350	Protein conserved in bacteria
HC662_14000	COG1388	LysM domain
HC662_14000	COG3409	Peptidoglycan-binding domain 1 protein
HC662_14000	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_14020	COG4195	phage-related replication protein
HC662_14030	COG3546	catalase activity
HC662_14040	COG2856	Zn peptidase
HC662_14050	COG1396	sequence-specific DNA binding
HC662_14070	COG1522	sequence-specific DNA binding
HC662_14080	COG1484	DNA-dependent DNA replication
HC662_14120	COG1595	DNA-templated transcription, initiation
HC662_14130	COG5484	DNA packaging
HC662_14130	COG3728	DNA packaging
HC662_14140	COG1783	phage Terminase large subunit
HC662_14150	COG5518	Phage portal protein
HC662_14160	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC662_14170	COG4653	Phage capsid family
HC662_14270	COG3953	SLT domain
HC662_14270	COG5412	phage tail tape measure protein
HC662_14280	COG1652	LysM domain
HC662_14290	COG4193	domain, Protein
HC662_14310	COG3628	GPW Gp25 family protein
HC662_14320	COG3299	homolog of phage Mu protein gp47
HC662_14330	COG3778	Protein conserved in bacteria
HC662_14410	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_14410	COG3409	Peptidoglycan-binding domain 1 protein
HC662_14440	COG0306	phosphate transporter
HC662_14450	COG1392	Phosphate transport regulator
HC662_14460	COG0531	amino acid
HC662_14480	COG0346	lactoylglutathione lyase activity
HC662_14490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC662_14500	COG0463	Glycosyl transferase, family 2
HC662_14510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_14520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC662_14530	COG2362	D-Aminopeptidase
HC662_14540	COG0601	transmembrane transport
HC662_14550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_14560	COG0444	Belongs to the ABC transporter superfamily
HC662_14570	COG4166	transmembrane transport
HC662_14580	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC662_14590	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_14600	COG0791	NLP P60 protein
HC662_14610	COG4608	Belongs to the ABC transporter superfamily
HC662_14620	COG2706	6-phosphogluconolactonase activity
HC662_14630	COG1834	amidinotransferase
HC662_14640	COG1607	acyl-coa hydrolase
HC662_14650	COG1017	nitric oxide dioxygenase activity
HC662_14650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC662_14670	COG2323	membrane
HC662_14680	COG2318	DinB family
HC662_14690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_14700	COG2076	Multidrug Resistance protein
HC662_14710	COG2076	Multidrug Resistance protein
HC662_14720	COG0788	formyltetrahydrofolate deformylase activity
HC662_14730	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC662_14740	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC662_14750	COG1764	response to oxidative stress
HC662_14760	COG1846	Transcriptional regulator
HC662_14770	COG1764	response to oxidative stress
HC662_14780	COG0463	Glycosyl transferase, family 2
HC662_14780	COG0457	Tetratricopeptide repeat
HC662_14790	COG0590	tRNA wobble adenosine to inosine editing
HC662_14800	COG0406	alpha-ribazole phosphatase activity
HC662_14810	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC662_14820	COG1404	Belongs to the peptidase S8 family
HC662_14830	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_14840	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC662_14850	COG1122	ATPase activity
HC662_14860	COG4721	ABC-type cobalt transport system, permease component
HC662_14880	COG0745	RESPONSE REGULATOR receiver
HC662_14890	COG3850	Histidine kinase
HC662_14890	COG5002	protein histidine kinase activity
HC662_14900	COG3212	peptidase
HC662_14910	COG3212	peptidase
HC662_14920	COG2239	Acts as a magnesium transporter
HC662_14930	COG0789	Transcriptional regulator
HC662_14960	COG1846	Transcriptional regulator
HC662_14970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC662_14980	COG0726	polysaccharide deacetylase
HC662_14990	COG1408	metallophosphoesterase
HC662_15010	COG0463	Glycosyl transferase, family 2
HC662_15020	COG3285	dna ligase
HC662_15020	COG1793	dna ligase
HC662_15030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC662_15040	COG3300	MHYT domain
HC662_15040	COG5001	Diguanylate cyclase
HC662_15050	COG0586	Pfam SNARE associated Golgi protein
HC662_15060	COG0861	Integral membrane protein TerC family
HC662_15070	COG1191	sigma factor activity
HC662_15110	COG0501	Belongs to the peptidase M48B family
HC662_15120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC662_15150	COG3594	Acyltransferase
HC662_15160	COG5002	protein histidine kinase activity
HC662_15170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC662_15180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC662_15190	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HC662_15200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC662_15210	COG0436	Aminotransferase
HC662_15220	COG1850	ribulose-bisphosphate carboxylase activity
HC662_15230	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HC662_15240	COG0235	Class ii aldolase
HC662_15250	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HC662_15260	COG3339	Conserved Protein
HC662_15290	COG3852	Histidine kinase
HC662_15300	COG1846	Transcriptional regulator
HC662_15310	COG1360	Flagellar Motor Protein
HC662_15320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC662_15330	COG0542	response to heat
HC662_15340	COG3949	Membrane
HC662_15350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HC662_15360	COG0720	synthase
HC662_15370	COG0602	queuosine metabolic process
HC662_15380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HC662_15390	COG1388	LysM domain
HC662_15390	COG4641	Protein conserved in bacteria
HC662_15400	COG1388	LysM domain
HC662_15410	COG3858	chitin binding
HC662_15430	COG4873	Protein conserved in bacteria
HC662_15450	COG3773	Cell wall hydrolase
HC662_15460	COG2244	polysaccharide biosynthetic process
HC662_15470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_15480	COG2217	Heavy metal translocating P-type atpase
HC662_15500	COG0006	proline dipeptidase activity
HC662_15510	COG1609	Transcriptional regulator
HC662_15520	COG3711	transcriptional antiterminator
HC662_15530	COG2190	(PTS) system
HC662_15530	COG1263	PTS System
HC662_15530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_15540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_15550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC662_15570	COG1533	DNA photolyase activity
HC662_15580	COG0456	acetyltransferase
HC662_15590	COG0840	transmembrane signaling receptor activity
HC662_15600	COG0006	proline dipeptidase activity
HC662_15610	COG1609	Transcriptional regulator
HC662_15620	COG3711	transcriptional antiterminator
HC662_15630	COG2190	(PTS) system
HC662_15630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_15630	COG1263	PTS System
HC662_15640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_15650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC662_15670	COG1533	DNA photolyase activity
HC662_15680	COG0456	acetyltransferase
HC662_15690	COG0840	transmembrane signaling receptor activity
HC662_15700	COG2084	Dehydrogenase
HC662_15710	COG4257	antibiotic catabolic process
HC662_15730	COG2340	Cysteine-rich secretory protein family
HC662_15740	COG0768	penicillin binding
HC662_15750	COG4191	Histidine kinase
HC662_15760	COG0436	Aminotransferase
HC662_15780	COG0784	Response regulator, receiver
HC662_15780	COG0835	chemotaxis
HC662_15800	COG2814	Major facilitator Superfamily
HC662_15810	COG1376	ErfK ybiS ycfS ynhG family protein
HC662_15820	COG1408	metallophosphoesterase
HC662_15830	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_15840	COG2200	EAL domain
HC662_15860	COG4703	Protein of unknown function (DUF1797)
HC662_15870	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HC662_15890	COG0517	IMP dehydrogenase activity
HC662_15900	COG0583	DNA-binding transcription factor activity
HC662_15910	COG0716	FMN binding
HC662_15930	COG0716	FMN binding
HC662_15940	COG2171	N-acyltransferase activity
HC662_15950	COG1473	amidohydrolase
HC662_15970	COG0668	transmembrane transport
HC662_15980	COG0450	alkyl hydroperoxide reductase
HC662_15990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_16020	COG0746	molybdenum cofactor guanylyltransferase activity
HC662_16030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC662_16040	COG0303	'Molybdopterin
HC662_16050	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC662_16060	COG0314	molybdopterin synthase activity
HC662_16070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC662_16080	COG1132	(ABC) transporter
HC662_16090	COG1132	(ABC) transporter
HC662_16110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC662_16120	COG1136	(ABC) transporter
HC662_16130	COG0577	efflux transmembrane transporter activity
HC662_16140	COG1349	DNA-binding transcription factor activity
HC662_16150	COG1105	Belongs to the carbohydrate kinase PfkB family
HC662_16160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_16160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC662_16160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_16170	COG0681	Belongs to the peptidase S26 family
HC662_16190	COG0488	(ABC) transporter
HC662_16200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC662_16210	COG2309	aminopeptidase activity
HC662_16220	COG1077	Cell shape determining protein MreB Mrl
HC662_16230	COG2002	toxin-antitoxin pair type II binding
HC662_16240	COG3852	Histidine kinase
HC662_16250	COG2105	PFAM AIG2 family protein
HC662_16250	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC662_16260	COG0569	domain protein
HC662_16270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC662_16280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC662_16300	COG0561	phosphatase activity
HC662_16310	COG0242	peptide deformylase activity
HC662_16320	COG0497	DNA recombination
HC662_16330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC662_16340	COG0022	dehydrogenase e1 component
HC662_16350	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC662_16360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC662_16370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_16380	COG1982	Orn Lys Arg decarboxylase major
HC662_16390	COG4476	Belongs to the UPF0223 family
HC662_16400	COG4493	Belongs to the UPF0637 family
HC662_16420	COG0483	inositol monophosphate 1-phosphatase activity
HC662_16440	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC662_16460	COG1959	2 iron, 2 sulfur cluster binding
HC662_16500	COG1595	DNA-templated transcription, initiation
HC662_16560	COG4896	Protein conserved in bacteria
HC662_16580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC662_16590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC662_16600	COG2066	Belongs to the glutaminase family
HC662_16610	COG4838	Belongs to the UPF0358 family
HC662_16620	COG0772	Belongs to the SEDS family
HC662_16630	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC662_16640	COG1612	heme a metabolic process
HC662_16650	COG0109	protoheme IX farnesyltransferase activity
HC662_16660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC662_16660	COG2010	Cytochrome c
HC662_16670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC662_16680	COG1845	cytochrome c oxidase, subunit III
HC662_16690	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC662_16700	COG3336	cytochrome c oxidase
HC662_16720	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HC662_16730	COG2340	Cysteine-rich secretory protein family
HC662_16760	COG3679	Belongs to the UPF0342 family
HC662_16770	COG4471	UPF0298 protein
HC662_16780	COG0742	ribosomal rna small subunit methyltransferase
HC662_16790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC662_16800	COG3314	Sporulation integral membrane protein YlbJ
HC662_16810	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC662_16820	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC662_16830	COG1323	Belongs to the UPF0348 family
HC662_16850	COG1399	metal-binding, possibly nucleic acid-binding protein
HC662_16880	COG0454	-acetyltransferase
HC662_16890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC662_16900	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HC662_16910	COG2001	Belongs to the MraZ family
HC662_16920	COG0275	rRNA processing
HC662_16930	COG4839	cell division protein FtsL
HC662_16950	COG0768	penicillin binding
HC662_16960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC662_16970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC662_16980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC662_16990	COG0772	Belongs to the SEDS family
HC662_17000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC662_17010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC662_17020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC662_17030	COG3879	Bacterial protein of unknown function (DUF881)
HC662_17040	COG3879	Bacterial protein of unknown function (DUF881)
HC662_17050	COG3856	small basic protein
HC662_17060	COG0849	cell division
HC662_17070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC662_17080	COG4412	M6 family metalloprotease domain protein
HC662_17080	COG1404	Belongs to the peptidase S8 family
HC662_17100	COG1191	sigma factor activity
HC662_17110	COG1191	sigma factor activity
HC662_17120	COG1119	ATPase activity
HC662_17130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_17140	COG1873	PFAM PRC-barrel domain
HC662_17160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC662_17170	COG1799	cell septum assembly
HC662_17180	COG0762	integral membrane protein
HC662_17190	COG2302	S4 RNA-binding domain
HC662_17200	COG3599	regulation of cell shape
HC662_17210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC662_17220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC662_17230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC662_17240	COG0564	pseudouridine synthase activity
HC662_17250	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC662_17260	COG2233	PERMEase
HC662_17270	COG0540	Belongs to the ATCase OTCase family
HC662_17280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC662_17290	COG0505	Belongs to the CarA family
HC662_17300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC662_17310	COG0543	2 iron, 2 sulfur cluster binding
HC662_17320	COG0167	dihydroorotate dehydrogenase activity
HC662_17330	COG0284	orotidine-5'-phosphate decarboxylase activity
HC662_17340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC662_17350	COG0175	sulfate reduction
HC662_17360	COG0306	phosphate transporter
HC662_17370	COG2046	Belongs to the sulfate adenylyltransferase family
HC662_17380	COG0529	Catalyzes the synthesis of activated sulfate
HC662_17390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC662_17400	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HC662_17410	COG1648	precorrin-2 dehydrogenase activity
HC662_17420	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HC662_17430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC662_17440	COG1561	YicC-like family, N-terminal region
HC662_17460	COG0194	GDP metabolic process
HC662_17470	COG1758	RNA polymerase activity
HC662_17480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC662_17490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC662_17500	COG0242	peptide deformylase activity
HC662_17510	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC662_17520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC662_17520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC662_17530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC662_17540	COG0631	protein serine/threonine phosphatase activity
HC662_17550	COG0515	serine threonine protein kinase
HC662_17550	COG2815	serine threonine protein kinase
HC662_17560	COG1162	GTPase activity
HC662_17570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC662_17580	COG1564	THIamine pyrophosphokinase
HC662_17590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC662_17600	COG1302	Protein conserved in bacteria
HC662_17610	COG1461	Dihydroxyacetone kinase
HC662_17620	COG1760	l-serine dehydratase
HC662_17630	COG1760	l-serine dehydratase
HC662_17640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC662_17650	COG1349	DNA-binding transcription factor activity
HC662_17650	COG2050	protein possibly involved in aromatic compounds catabolism
HC662_17660	COG0416	fatty acid biosynthetic process
HC662_17670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC662_17680	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_17700	COG0571	ribonuclease III activity
HC662_17710	COG1196	nuclear chromosome segregation
HC662_17720	COG0552	protein localization to endoplasmic reticulum
HC662_17740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HC662_17750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC662_17760	COG0228	four-way junction DNA binding
HC662_17770	COG1837	Belongs to the UPF0109 family
HC662_17790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC662_17800	COG0336	Belongs to the RNA methyltransferase TrmD family
HC662_17810	COG0335	large ribosomal subunit rRNA binding
HC662_17820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC662_17830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC662_17860	COG2257	FlhB HrpN YscU SpaS Family
HC662_17870	COG0045	succinate-CoA ligase (ADP-forming) activity
HC662_17880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC662_17890	COG0758	DNA mediated transformation
HC662_17900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC662_17910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HC662_17920	COG4974	Belongs to the 'phage' integrase family
HC662_17930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC662_17940	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC662_17950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC662_17960	COG1815	bacterial-type flagellum-dependent cell motility
HC662_17970	COG1558	bacterial-type flagellum-dependent cell motility
HC662_17980	COG1677	Flagellar hook-basal body complex protein FliE
HC662_17990	COG1766	The M ring may be actively involved in energy transduction
HC662_18000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC662_18010	COG1317	bacterial-type flagellum organization
HC662_18020	COG1157	protein secretion by the type III secretion system
HC662_18030	COG2882	bacterial-type flagellum organization
HC662_18040	COG3334	PFAM MgtE intracellular
HC662_18050	COG3144	bacterial-type flagellum assembly
HC662_18060	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HC662_18070	COG4786	Flagellar basal body rod
HC662_18080	COG1582	Flagellar protein (FlbD)
HC662_18090	COG1580	Controls the rotational direction of flagella during chemotaxis
HC662_18100	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC662_18110	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC662_18110	COG1776	CheC inhibitor of MCP methylation
HC662_18120	COG2201	protein-glutamate methylesterase activity
HC662_18130	COG3190	flagellar
HC662_18140	COG1338	Plays a role in the flagellum-specific transport system
HC662_18150	COG1987	bacterial-type flagellum assembly
HC662_18160	COG1684	flagellar biosynthetic protein fliR
HC662_18170	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC662_18180	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC662_18190	COG1419	protein localization to endoplasmic reticulum
HC662_18200	COG0455	bacterial-type flagellum organization
HC662_18210	COG2201	protein-glutamate methylesterase activity
HC662_18220	COG0643	Histidine kinase
HC662_18220	COG2198	Histidine kinase
HC662_18230	COG0835	chemotaxis
HC662_18240	COG1776	CheC inhibitor of MCP methylation
HC662_18250	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HC662_18260	COG1191	sigma factor activity
HC662_18280	COG0052	Belongs to the universal ribosomal protein uS2 family
HC662_18290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC662_18300	COG0528	UMP kinase activity
HC662_18310	COG0233	cytoplasmic translational termination
HC662_18320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC662_18330	COG4589	Belongs to the CDS family
HC662_18340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC662_18350	COG0750	zinc metalloprotease
HC662_18360	COG0442	prolyl-tRNA aminoacylation
HC662_18370	COG2176	DNA-directed DNA polymerase activity
HC662_18380	COG0779	Required for maturation of 30S ribosomal subunits
HC662_18390	COG0195	Participates in both transcription termination and antitermination
HC662_18400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC662_18410	COG1358	cellular component organization or biogenesis
HC662_18420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC662_18430	COG1550	Protein conserved in bacteria
HC662_18440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC662_18450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC662_18460	COG0196	riboflavin kinase activity
HC662_18480	COG1185	polyribonucleotide nucleotidyltransferase activity
HC662_18490	COG0726	polysaccharide deacetylase
HC662_18500	COG0612	Peptidase, M16
HC662_18510	COG1873	PFAM PRC-barrel domain
HC662_18520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC662_18530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC662_18540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC662_18550	COG0527	aspartate kinase activity
HC662_18560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC662_18570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC662_18580	COG0740	serine-type endopeptidase activity
HC662_18600	COG4980	gas vesicle protein
HC662_18600	COG1674	ftsk spoiiie
HC662_18610	COG2188	Transcriptional regulator
HC662_18620	COG1418	mRNA catabolic process
HC662_18630	COG1692	metallophosphoesterase
HC662_18640	COG2359	stage V sporulation protein S
HC662_18650	COG1063	alcohol dehydrogenase
HC662_18660	COG0156	8-amino-7-oxononanoate synthase activity
HC662_18670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC662_18680	COG4550	Control of competence regulator ComK, YlbF/YmcA
HC662_18700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC662_18710	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC662_18740	COG3226	Transcriptional regulator
HC662_18760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_18770	COG1404	Belongs to the peptidase S8 family
HC662_18790	COG4195	phage-related replication protein
HC662_18800	COG1764	response to oxidative stress
HC662_18840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC662_18850	COG1923	regulation of RNA biosynthetic process
HC662_18880	COG1780	Probably involved in ribonucleotide reductase function
HC662_18890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC662_18900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC662_18910	COG4112	unkown
HC662_18920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_18930	COG0464	growth
HC662_18940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC662_18950	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HC662_18960	COG0789	Transcriptional regulator
HC662_18970	COG0174	glutamine synthetase
HC662_19010	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC662_19020	COG1733	regulation of RNA biosynthetic process
HC662_19070	COG0135	phosphoribosylanthranilate isomerase activity
HC662_19090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_19120	COG2211	Major facilitator Superfamily
HC662_19130	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_19160	COG1070	Carbohydrate kinase
HC662_19180	COG1525	nuclease
HC662_19190	COG2814	Major facilitator Superfamily
HC662_19210	COG0756	dUTP diphosphatase activity
HC662_19290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC662_19310	COG3832	glyoxalase III activity
HC662_19330	COG2059	Chromate
HC662_19340	COG0697	spore germination
HC662_19350	COG0531	amino acid
HC662_19400	COG4195	phage-related replication protein
HC662_19420	COG0346	lactoylglutathione lyase activity
HC662_19430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC662_19440	COG1388	LysM domain
HC662_19450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC662_19460	COG4224	UPF0291 protein
HC662_19470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC662_19490	COG3763	UPF0154 protein
HC662_19510	COG0785	Cytochrome C biogenesis protein
HC662_19520	COG2201	protein-glutamate methylesterase activity
HC662_19530	COG4846	Membrane protein involved in cytochrome C biogenesis
HC662_19550	COG0071	Belongs to the small heat shock protein (HSP20) family
HC662_19580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC662_19590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_19620	COG0824	Thioesterase
HC662_19640	COG4841	protein insertion into membrane
HC662_19650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC662_19660	COG1832	CoA-binding protein
HC662_19670	COG0187	DNA topoisomerase II activity
HC662_19680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC662_19700	COG1115	amino acid carrier protein
HC662_19710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HC662_19730	COG5520	Belongs to the glycosyl hydrolase 30 family
HC662_19740	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_19790	COG2246	polysaccharide biosynthetic process
HC662_19800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC662_19810	COG0586	Pfam SNARE associated Golgi protein
HC662_19820	COG2404	hydrolase activity, acting on ester bonds
HC662_19830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC662_19840	COG1024	Enoyl-CoA hydratase
HC662_19850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC662_19860	COG0511	ligase activity, forming carbon-carbon bonds
HC662_19870	COG0439	Biotin carboxylase
HC662_19880	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_19890	COG1960	acyl-CoA dehydrogenase activity
HC662_19930	COG1649	PFAM Uncharacterised BCR, COG1649
HC662_19950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_19950	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC662_19960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_19970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_19980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_19990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_20000	COG2027	D-alanyl-D-alanine carboxypeptidase
HC662_20010	COG2017	converts alpha-aldose to the beta-anomer
HC662_20020	COG0534	Mate efflux family protein
HC662_20050	COG0582	viral genome integration into host DNA
HC662_20060	COG0166	Belongs to the GPI family
HC662_20070	COG0405	Gamma-glutamyltransferase
HC662_20080	COG0583	DNA-binding transcription factor activity
HC662_20090	COG0604	alcohol dehydrogenase
HC662_20100	COG0493	'glutamate synthase
HC662_20110	COG0069	glutamate synthase activity
HC662_20110	COG0070	glutamate synthase
HC662_20110	COG0067	glutamate synthase
HC662_20120	COG0583	DNA-binding transcription factor activity
HC662_20130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC662_20160	COG0300	oxidoreductase activity
HC662_20170	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC662_20190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_20200	COG2814	Major facilitator Superfamily
HC662_20210	COG1070	Carbohydrate kinase
HC662_20220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC662_20230	COG0243	molybdopterin cofactor binding
HC662_20250	COG2814	Major facilitator Superfamily
HC662_20260	COG0673	inositol 2-dehydrogenase activity
HC662_20270	COG1082	Xylose isomerase domain protein TIM barrel
HC662_20280	COG1609	Transcriptional regulator
HC662_20300	COG0840	transmembrane signaling receptor activity
HC662_20300	COG5278	phosphoserine phosphatase activity
HC662_20310	COG2368	4-hydroxyphenylacetate
HC662_20320	COG4305	rare lipoprotein A
HC662_20330	COG3619	membrane
HC662_20350	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_20380	COG2135	peptidase activity
HC662_20400	COG2140	Oxalate decarboxylase
HC662_20420	COG0457	Tetratricopeptide repeat
HC662_20470	COG2720	vancomycin resistance protein
HC662_20490	COG3655	Transcriptional regulator
HC662_20500	COG3739	integral membrane protein
HC662_20510	COG0583	DNA-binding transcription factor activity
HC662_20520	COG0697	spore germination
HC662_20530	COG1388	LysM domain
HC662_20550	COG0693	protein deglycase activity
HC662_20560	COG2367	Beta-lactamase
HC662_20570	COG4282	regulation of fungal-type cell wall biogenesis
HC662_20580	COG3397	chitin binding
HC662_20590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC662_20600	COG3848	Pyruvate phosphate dikinase
HC662_20600	COG0574	Belongs to the PEP-utilizing enzyme family
HC662_20620	COG5444	nuclease activity
HC662_20630	COG4282	regulation of fungal-type cell wall biogenesis
HC662_20640	COG1231	oxidoreductase activity
HC662_20650	COG0726	polysaccharide deacetylase
HC662_20660	COG1793	dna ligase
HC662_20680	COG0582	viral genome integration into host DNA
HC662_20830	COG3655	Transcriptional regulator
HC662_20870	COG4935	Belongs to the peptidase S8 family
HC662_20870	COG1404	Belongs to the peptidase S8 family
HC662_20890	COG0457	Tetratricopeptide repeat
HC662_20900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_20940	COG1404	Belongs to the peptidase S8 family
HC662_20940	COG4935	Belongs to the peptidase S8 family
HC662_20980	COG5444	nuclease activity
HC662_20990	COG4282	regulation of fungal-type cell wall biogenesis
HC662_21010	COG1525	nuclease
HC662_21060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_21070	COG0662	Cupin 2, conserved barrel domain protein
HC662_21070	COG2207	Transcriptional regulator
HC662_21080	COG0456	acetyltransferase
HC662_21090	COG1309	transcriptional regulator
HC662_21100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_21110	COG3708	Transcriptional regulator
HC662_21120	COG2378	regulation of single-species biofilm formation
HC662_21140	COG0640	Transcriptional regulator
HC662_21150	COG0741	lytic transglycosylase activity
HC662_21160	COG2322	membrane
HC662_21190	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC662_21200	COG3239	Fatty acid desaturase
HC662_21210	COG4585	Histidine kinase
HC662_21220	COG2197	response regulator
HC662_21240	COG1388	LysM domain
HC662_21240	COG3584	3D domain protein
HC662_21250	COG0514	ATP-dependent DNA helicase (RecQ)
HC662_21260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC662_21270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC662_21300	COG1012	belongs to the aldehyde dehydrogenase family
HC662_21310	COG1657	PFAM Prenyltransferase squalene oxidase
HC662_21320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC662_21330	COG0733	neurotransmitter:sodium symporter activity
HC662_21340	COG0385	Bile acid
HC662_21350	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC662_21360	COG0567	Dehydrogenase, E1 component
HC662_21370	COG4548	von Willebrand factor, type A
HC662_21380	COG0714	Associated with various cellular activities
HC662_21390	COG2032	superoxide dismutase activity
HC662_21400	COG0791	NLP P60 protein
HC662_21400	COG1388	LysM domain
HC662_21410	COG1819	glycosyl
HC662_21420	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC662_21430	COG0534	Mate efflux family protein
HC662_21440	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_21450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC662_21460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC662_21480	COG2962	Rard protein
HC662_21510	COG2610	gluconate transmembrane transporter activity
HC662_21520	COG1942	4-Oxalocrotonate Tautomerase
HC662_21530	COG1733	regulation of RNA biosynthetic process
HC662_21540	COG0778	Nitroreductase
HC662_21550	COG0400	carboxylic ester hydrolase activity
HC662_21560	COG0346	lactoylglutathione lyase activity
HC662_21580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_21590	COG3409	Peptidoglycan-binding domain 1 protein
HC662_21590	COG0793	Belongs to the peptidase S41A family
HC662_21600	COG2226	methyltransferase
HC662_21620	COG1876	peptidase activity
HC662_21630	COG0813	purine-nucleoside phosphorylase activity
HC662_21650	COG0671	phosphoesterase, PA-phosphatase related
HC662_21680	COG4479	Belongs to the UPF0346 family
HC662_21700	COG1509	lysine 2,3-aminomutase activity
HC662_21710	COG0456	acetyltransferase
HC662_21720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_21730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC662_21740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC662_21750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC662_21760	COG0456	acetyltransferase
HC662_21770	COG0463	Glycosyl transferase, family 2
HC662_21800	COG4641	Protein conserved in bacteria
HC662_21810	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HC662_21820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC662_21840	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC662_21850	COG1846	Transcriptional regulator
HC662_21860	COG0534	Mate efflux family protein
HC662_21880	COG4698	Protein conserved in bacteria
HC662_21890	COG2755	lipolytic protein G-D-S-L family
HC662_21900	COG1999	signal sequence binding
HC662_21920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC662_21930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC662_21940	COG1272	protein, Hemolysin III
HC662_21950	COG0204	Acyl-transferase
HC662_21960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC662_21980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC662_22000	COG2521	methyltransferase
HC662_22000	COG2136	Putative SAM-dependent methyltransferase
HC662_22020	COG0129	dihydroxy-acid dehydratase activity
HC662_22030	COG1413	lyase activity
HC662_22040	COG1418	mRNA catabolic process
HC662_22050	COG0386	Belongs to the glutathione peroxidase family
HC662_22060	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HC662_22070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC662_22080	COG1278	Cold shock
HC662_22120	COG0328	RNA-DNA hybrid ribonuclease activity
HC662_22130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC662_22140	COG0328	RNA-DNA hybrid ribonuclease activity
HC662_22160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC662_22180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC662_22190	COG1755	Isoprenylcysteine carboxyl methyltransferase
HC662_22200	COG3424	synthase
HC662_22210	COG2233	PERMEase
HC662_22220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC662_22230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC662_22250	COG0800	Aldolase
HC662_22260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_22270	COG1609	Transcriptional regulator
HC662_22280	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC662_22290	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_22300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC662_22310	COG3935	DnaD domain protein
HC662_22320	COG0017	Asparaginyl-tRNA synthetase
HC662_22330	COG0436	Aminotransferase
HC662_22340	COG5353	protein conserved in bacteria
HC662_22360	COG1199	ATP-dependent helicase activity
HC662_22360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC662_22370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC662_22380	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC662_22390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC662_22400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC662_22400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC662_22410	COG0617	tRNA 3'-terminal CCA addition
HC662_22420	COG0438	transferase activity, transferring glycosyl groups
HC662_22430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC662_22440	COG1803	Methylglyoxal synthase
HC662_22450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC662_22460	COG1694	Mazg nucleotide pyrophosphohydrolase
HC662_22470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_22490	COG4347	Protein of unknown function (DUF1405)
HC662_22500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC662_22500	COG2010	Cytochrome c
HC662_22510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC662_22520	COG0723	plastoquinol--plastocyanin reductase activity
HC662_22540	COG5582	Belongs to the UPF0302 family
HC662_22550	COG0457	Tetratricopeptide repeat
HC662_22560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC662_22570	COG0287	Prephenate dehydrogenase
HC662_22580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC662_22590	COG0159	tryptophan synthase activity
HC662_22600	COG0133	tryptophan synthase activity
HC662_22610	COG0135	phosphoribosylanthranilate isomerase activity
HC662_22630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC662_22640	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC662_22650	COG4401	Chorismate mutase type I
HC662_22660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC662_22670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC662_22680	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC662_22690	COG0105	UTP biosynthetic process
HC662_22700	COG0142	geranyltranstransferase activity
HC662_22710	COG2226	methyltransferase
HC662_22720	COG0142	geranyltranstransferase activity
HC662_22740	COG0302	gtp cyclohydrolase
HC662_22750	COG0776	regulation of translation
HC662_22760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC662_22790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC662_22800	COG1160	GTP binding
HC662_22840	COG1304	FMN binding
HC662_22850	COG0539	negative regulation of cytoplasmic translation
HC662_22860	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC662_22880	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC662_22890	COG2959	enzyme of heme biosynthesis
HC662_22900	COG3773	Cell wall hydrolase
HC662_22900	COG3409	Peptidoglycan-binding domain 1 protein
HC662_22910	COG2339	peptidase activity
HC662_22920	COG0492	ferredoxin-NADP+ reductase activity
HC662_22930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC662_22940	COG4862	establishment of competence for transformation
HC662_22950	COG1408	metallophosphoesterase
HC662_22970	COG1388	LysM domain
HC662_22980	COG1266	CAAX protease self-immunity
HC662_22990	COG0514	ATP-dependent DNA helicase (RecQ)
HC662_23000	COG4955	Helix-turn-helix domain
HC662_23010	COG1141	Ferredoxin
HC662_23020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC662_23040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC662_23050	COG0710	3-dehydroquinate dehydratase activity
HC662_23070	COG1595	DNA-templated transcription, initiation
HC662_23080	COG5002	protein histidine kinase activity
HC662_23090	COG0745	RESPONSE REGULATOR receiver
HC662_23100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC662_23110	COG1333	cytochrome c biogenesis protein
HC662_23120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_23130	COG1187	pseudouridine synthase activity
HC662_23140	COG0700	Nucleoside recognition
HC662_23150	COG2715	membrane protein required for spore maturation
HC662_23160	COG1686	Belongs to the peptidase S11 family
HC662_23180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC662_23190	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC662_23200	COG1547	Domain of unknown function (DUF309)
HC662_23210	COG0456	acetyltransferase
HC662_23220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HC662_23230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC662_23230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC662_23240	COG0307	riboflavin synthase, alpha
HC662_23250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC662_23250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC662_23270	COG0681	Belongs to the peptidase S26 family
HC662_23280	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HC662_23300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC662_23310	COG4086	secreted protein
HC662_23320	COG0019	diaminopimelate decarboxylase activity
HC662_23330	COG0697	spore germination
HC662_23360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC662_23400	COG1191	sigma factor activity
HC662_23420	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_23430	COG1686	Belongs to the peptidase S11 family
HC662_23440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC662_23450	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC662_23460	COG4974	Belongs to the 'phage' integrase family
HC662_23480	COG0735	belongs to the Fur family
HC662_23490	COG1300	Membrane
HC662_23510	COG0281	malic enzyme
HC662_23520	COG1757	Na H antiporter
HC662_23530	COG1027	Aspartate ammonia-lyase
HC662_23540	COG0252	asparaginase activity
HC662_23550	COG1396	sequence-specific DNA binding
HC662_23560	COG1379	DNA repair
HC662_23570	COG0494	nUDIX hydrolase
HC662_23580	COG0667	Aldo Keto reductase
HC662_23600	COG1073	alpha beta
HC662_23620	COG4918	Iron-sulphur cluster biosynthesis
HC662_23630	COG0456	acetyltransferase
HC662_23630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC662_23640	COG2329	Antibiotic biosynthesis monooxygenase
HC662_23650	COG0456	acetyltransferase
HC662_23670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_23690	COG2211	Major facilitator Superfamily
HC662_23710	COG0346	lactoylglutathione lyase activity
HC662_23720	COG1072	(Pantothenic acid kinase))
HC662_23730	COG3048	D-serine ammonia-lyase activity
HC662_23740	COG0300	oxidoreductase activity
HC662_23750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_23760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC662_23770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC662_23790	COG0706	membrane insertase activity
HC662_23800	COG3361	conserved protein (COG2071)
HC662_23810	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC662_23820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC662_23830	COG0346	lactoylglutathione lyase activity
HC662_23840	COG1376	ErfK ybiS ycfS ynhG family protein
HC662_23850	COG4129	membrane
HC662_23860	COG1126	abc transporter atp-binding protein
HC662_23870	COG0765	amino acid transport
HC662_23880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_23900	COG1597	lipid kinase activity
HC662_23910	COG2814	Major facilitator Superfamily
HC662_23920	COG0789	Transcriptional regulator
HC662_23920	COG4978	Transcriptional regulator
HC662_23930	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC662_23940	COG0022	dehydrogenase e1 component
HC662_23950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC662_23960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC662_23970	COG3426	butyrate kinase activity
HC662_23980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC662_23990	COG0280	phosphate acetyltransferase
HC662_24000	COG3290	protein histidine kinase activity
HC662_24000	COG3829	transcription factor binding
HC662_24020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC662_24030	COG2079	MmgE PrpD family protein
HC662_24040	COG0372	Belongs to the citrate synthase family
HC662_24050	COG1960	acyl-CoA dehydrogenase activity
HC662_24060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC662_24070	COG0183	Belongs to the thiolase family
HC662_24080	COG0584	glycerophosphoryl diester phosphodiesterase
HC662_24090	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_24110	COG1902	pentaerythritol trinitrate reductase activity
HC662_24120	COG0745	RESPONSE REGULATOR receiver
HC662_24130	COG0750	zinc metalloprotease
HC662_24140	COG0497	DNA recombination
HC662_24150	COG1438	arginine binding
HC662_24160	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC662_24170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC662_24180	COG0142	geranyltranstransferase activity
HC662_24190	COG1722	exodeoxyribonuclease VII activity
HC662_24200	COG1570	exodeoxyribonuclease VII activity
HC662_24210	COG3854	ATPases associated with a variety of cellular activities
HC662_24230	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC662_24240	COG0006	proline dipeptidase activity
HC662_24250	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC662_24270	COG3872	metal-dependent enzyme
HC662_24290	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC662_24300	COG1321	iron dependent repressor
HC662_24310	COG0095	Lipoate-protein ligase
HC662_24320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_24330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC662_24340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC662_24350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC662_24360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC662_24390	COG1396	sequence-specific DNA binding
HC662_24410	COG0681	Belongs to the peptidase S26 family
HC662_24460	COG4940	Competence protein ComGF
HC662_24480	COG4970	Tfp pilus assembly protein FimT
HC662_24490	COG4537	Required for transformation and DNA binding
HC662_24500	COG1459	type II secretion system
HC662_24510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC662_24520	COG0517	IMP dehydrogenase activity
HC662_24530	COG0598	Magnesium transport protein CorA
HC662_24540	COG1253	flavin adenine dinucleotide binding
HC662_24550	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_24570	COG1393	Belongs to the ArsC family
HC662_24590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_24610	COG0011	TIGRFAM Protein of
HC662_24630	COG2866	Carboxypeptidase
HC662_24640	COG1368	sulfuric ester hydrolase activity
HC662_24650	COG1940	carbohydrate kinase activity
HC662_24660	COG4483	Protein conserved in bacteria
HC662_24670	COG0705	Rhomboid family
HC662_24670	COG0457	Tetratricopeptide repeat
HC662_24690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC662_24710	COG0438	transferase activity, transferring glycosyl groups
HC662_24740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC662_24750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC662_24760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC662_24770	COG0581	inorganic phosphate transmembrane transporter activity
HC662_24780	COG0573	inorganic phosphate transmembrane transporter activity
HC662_24790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC662_24810	COG0477	Major facilitator Superfamily
HC662_24820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC662_24830	COG2839	Protein conserved in bacteria
HC662_24840	COG5521	maltodextrose utilization protein MalA
HC662_24850	COG1388	LysM domain
HC662_24860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC662_24870	COG4709	membrane
HC662_24880	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HC662_24890	COG0735	belongs to the Fur family
HC662_24900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_24920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC662_24930	COG0513	Belongs to the DEAD box helicase family
HC662_24950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC662_24960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC662_24970	COG2384	SAM-dependent methyltransferase
HC662_24980	COG2384	SAM-dependent methyltransferase
HC662_24990	COG2010	Cytochrome c
HC662_25000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC662_25010	COG0358	DNA primase activity
HC662_25020	COG1671	Belongs to the UPF0178 family
HC662_25030	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC662_25040	COG0517	IMP dehydrogenase activity
HC662_25050	COG0751	glycine-tRNA ligase activity
HC662_25060	COG0752	glycyl-tRNA synthetase alpha subunit
HC662_25070	COG1381	Involved in DNA repair and RecF pathway recombination
HC662_25080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC662_25090	COG0295	cytidine deaminase activity
HC662_25110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC662_25120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC662_25130	COG1480	7TM receptor with intracellular HD hydrolase
HC662_25140	COG1702	phosphate starvation-inducible protein PhoH
HC662_25150	COG0561	phosphatase activity
HC662_25180	COG4864	UPF0365 protein
HC662_25190	COG1030	water channel activity
HC662_25200	COG1610	YqeY-like protein
HC662_25220	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC662_25230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC662_25240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC662_25250	COG2264	protein methyltransferase activity
HC662_25290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC662_25300	COG1420	regulation of RNA biosynthetic process
HC662_25310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC662_25320	COG0481	GTPase activity
HC662_25340	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_25350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC662_25360	COG0268	Binds directly to 16S ribosomal RNA
HC662_25370	COG1466	dna polymerase III delta subunit
HC662_25380	COG0658	competence protein
HC662_25380	COG2333	competence protein COMEC
HC662_25390	COG2131	deaminase
HC662_25400	COG1555	photosystem II stabilization
HC662_25400	COG1596	polysaccharide export
HC662_25410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC662_25420	COG2226	methyltransferase
HC662_25430	COG0799	negative regulation of ribosome biogenesis
HC662_25440	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC662_25450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC662_25460	COG1534	Rna-binding protein
HC662_25470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC662_25480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC662_25490	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC662_25500	COG2755	lipolytic protein G-D-S-L family
HC662_25510	COG3409	Peptidoglycan-binding domain 1 protein
HC662_25510	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_25520	COG0398	Pfam SNARE associated Golgi protein
HC662_25530	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HC662_25550	COG3209	COG3209 Rhs family protein
HC662_25570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC662_25580	COG2323	membrane
HC662_25590	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC662_25600	COG0730	response to heat
HC662_25610	COG0425	Belongs to the sulfur carrier protein TusA family
HC662_25620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_25620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_25630	COG2210	Belongs to the sulfur carrier protein TusA family
HC662_25640	COG0425	Belongs to the sulfur carrier protein TusA family
HC662_25640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_25660	COG2210	Belongs to the sulfur carrier protein TusA family
HC662_25670	COG1937	Protein conserved in bacteria
HC662_25690	COG0662	Cupin 2, conserved barrel domain protein
HC662_25710	COG0604	alcohol dehydrogenase
HC662_25720	COG2315	Protein conserved in bacteria
HC662_25730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC662_25760	COG0583	DNA-binding transcription factor activity
HC662_25770	COG0457	Tetratricopeptide repeat
HC662_25800	COG5444	nuclease activity
HC662_25810	COG3409	Peptidoglycan-binding domain 1 protein
HC662_25810	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC662_25820	COG4824	toxin secretion phage lysis holin
HC662_25870	COG0563	adenylate kinase activity
HC662_25940	COG0697	spore germination
HC662_25950	COG1917	Cupin 2, conserved barrel domain protein
HC662_25950	COG2207	Transcriptional regulator
HC662_25960	COG2318	DinB family
HC662_25970	COG0456	acetyltransferase
HC662_25980	COG0477	Major facilitator Superfamily
HC662_25990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC662_26040	COG0789	Transcriptional regulator
HC662_26040	COG4978	Transcriptional regulator
HC662_26050	COG0747	negative chemotaxis
HC662_26060	COG0601	transmembrane transport
HC662_26070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC662_26080	COG0444	Belongs to the ABC transporter superfamily
HC662_26090	COG4608	Belongs to the ABC transporter superfamily
HC662_26100	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC662_26110	COG1595	DNA-templated transcription, initiation
HC662_26120	COG2851	Citrate transporter
HC662_26130	COG0583	DNA-binding transcription factor activity
HC662_26140	COG2828	Protein conserved in bacteria
HC662_26150	COG3409	Peptidoglycan-binding domain 1 protein
HC662_26160	COG5566	PFAM Mor transcription activator
HC662_26170	COG0596	Alpha beta hydrolase
HC662_26180	COG0697	spore germination
HC662_26190	COG0110	maltose O-acetyltransferase activity
HC662_26200	COG4991	sh3 domain protein
HC662_26210	COG4991	sh3 domain protein
HC662_26230	COG5577	PFAM Coat F domain
HC662_26240	COG1063	alcohol dehydrogenase
HC662_26260	COG5577	PFAM Coat F domain
HC662_26270	COG0667	Aldo Keto reductase
HC662_26280	COG0693	protein deglycase activity
HC662_26290	COG1621	beta-fructofuranosidase activity
HC662_26300	COG3716	PTS system mannose fructose sorbose family IID component
HC662_26310	COG3715	PTS system
HC662_26320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_26330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_26340	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC662_26340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC662_26350	COG1113	amino acid transport
HC662_26360	COG1280	lysine exporter protein (LysE YggA)
HC662_26370	COG1378	Sugar-specific transcriptional regulator TrmB
HC662_26380	COG1595	DNA-templated transcription, initiation
HC662_26400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC662_26400	COG2755	lipolytic protein G-D-S-L family
HC662_26420	COG2124	cytochrome p450
HC662_26420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC662_26430	COG1309	transcriptional regulator
HC662_26440	COG2226	methyltransferase
HC662_26470	COG2116	formate transmembrane transporter activity
HC662_26480	COG5609	conserved protein (DUF2294)
HC662_26490	COG3383	formate dehydrogenase (NAD+) activity
HC662_26500	COG2427	Protein of unknown function (DUF1641)
HC662_26520	COG0626	cystathionine gamma-synthase activity
HC662_26530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC662_26540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC662_26550	COG2226	methyltransferase
HC662_26580	COG0768	penicillin binding
HC662_26590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC662_26600	COG0572	uridine kinase
HC662_26630	COG4122	O-methyltransferase activity
HC662_26640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC662_26650	COG3906	Belongs to the UPF0473 family
HC662_26660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC662_26670	COG4472	Bacterial protein of unknown function (DUF965)
HC662_26680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC662_26690	COG0628	permease
HC662_26700	COG1126	abc transporter atp-binding protein
HC662_26710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_26720	COG0765	amino acid transport
HC662_26730	COG0765	amino acid transport
HC662_26750	COG3881	PFAM PRC-barrel domain
HC662_26760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC662_26770	COG0457	Tetratricopeptide repeat
HC662_26780	COG0482	sulfurtransferase activity
HC662_26790	COG1104	cysteine desulfurase activity
HC662_26800	COG1959	2 iron, 2 sulfur cluster binding
HC662_26810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC662_26820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC662_26830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC662_26840	COG0124	histidyl-tRNA synthetase
HC662_26860	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_26860	COG3103	Sh3 type 3 domain protein
HC662_26860	COG4991	sh3 domain protein
HC662_26870	COG1490	D-aminoacyl-tRNA deacylase activity
HC662_26880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC662_26890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC662_26900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC662_26900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC662_26910	COG5416	Lipopolysaccharide assembly protein A domain
HC662_26920	COG0490	domain, Protein
HC662_26930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC662_26930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC662_26950	COG2244	polysaccharide biosynthetic process
HC662_26960	COG2323	membrane
HC662_26980	COG1862	Preprotein translocase
HC662_26990	COG0343	queuine tRNA-ribosyltransferase activity
HC662_27000	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC662_27020	COG2255	four-way junction helicase activity
HC662_27030	COG0632	four-way junction helicase activity
HC662_27050	COG2814	Major facilitator Superfamily
HC662_27060	COG0673	inositol 2-dehydrogenase activity
HC662_27070	COG2112	serine threonine protein kinase
HC662_27090	COG1115	amino acid carrier protein
HC662_27100	COG0217	transcriptional regulatory protein
HC662_27120	COG1388	LysM domain
HC662_27130	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC662_27140	COG0157	Belongs to the NadC ModD family
HC662_27150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC662_27160	COG1104	cysteine desulfurase activity
HC662_27170	COG1827	regulation of RNA biosynthetic process
HC662_27180	COG0077	Prephenate dehydratase
HC662_27190	COG4492	Belongs to the UPF0735 family
HC662_27200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC662_27210	COG3290	protein histidine kinase activity
HC662_27220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC662_27230	COG2868	ribosomal protein
HC662_27240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC662_27250	COG1994	Peptidase M50
HC662_27260	COG0739	heme binding
HC662_27270	COG2894	cell division
HC662_27280	COG0850	regulation of cytokinetic process
HC662_27290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC662_27310	COG1077	Cell shape determining protein MreB Mrl
HC662_27320	COG2003	Belongs to the UPF0758 family
HC662_27330	COG0424	maF-like protein
HC662_27350	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC662_27360	COG0285	dihydrofolate synthase activity
HC662_27370	COG0525	valine-tRNA ligase activity
HC662_27390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC662_27400	COG1388	LysM domain
HC662_27410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC662_27420	COG0113	porphobilinogen synthase activity
HC662_27430	COG1587	Uroporphyrinogen-III synthase
HC662_27440	COG0181	hydroxymethylbilane synthase activity
HC662_27450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC662_27460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC662_27480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC662_27490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC662_27500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC662_27510	COG0470	DNA polymerase III
HC662_27510	COG1067	ATP-dependent peptidase activity
HC662_27520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC662_27530	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC662_27540	COG0457	Tetratricopeptide repeat
HC662_27540	COG1477	protein flavinylation
HC662_27550	COG0066	3-isopropylmalate dehydratase activity
HC662_27560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC662_27570	COG0473	3-isopropylmalate dehydrogenase activity
HC662_27580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC662_27590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC662_27600	COG0440	acetolactate synthase activity
HC662_27610	COG0028	Belongs to the TPP enzyme family
HC662_27630	COG0454	-acetyltransferase
HC662_27640	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HC662_27660	COG0622	Phosphoesterase
HC662_27670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC662_27680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC662_27690	COG5401	PFAM Sporulation and spore germination
HC662_27700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC662_27710	COG1846	Transcriptional regulator
HC662_27720	COG2197	response regulator
HC662_27730	COG0824	Thioesterase
HC662_27740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC662_27750	COG1053	succinate dehydrogenase
HC662_27760	COG2009	succinate dehydrogenase
HC662_27770	COG1719	4-vinyl reductase, 4VR
HC662_27780	COG0527	aspartate kinase activity
HC662_27790	COG0322	excinuclease ABC activity
HC662_27800	COG3118	belongs to the thioredoxin family
HC662_27820	COG3534	alpha-L-arabinofuranosidase
HC662_27830	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC662_27840	COG2086	electron transfer activity
HC662_27850	COG1024	Enoyl-CoA hydratase
HC662_27860	COG1309	transcriptional regulator
HC662_27870	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_27880	COG3766	membrane
HC662_27890	COG1193	negative regulation of DNA recombination
HC662_27900	COG1796	DNA polymerase
HC662_27900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC662_27910	COG1286	toxin biosynthetic process
HC662_27920	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HC662_27930	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC662_27940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_27940	COG0072	phenylalanine-tRNA ligase activity
HC662_27950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC662_27960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC662_27980	COG3835	regulator
HC662_27990	COG0277	FAD linked oxidase domain protein
HC662_28000	COG0247	lactate metabolic process
HC662_28010	COG0346	lactoylglutathione lyase activity
HC662_28020	COG1966	Carbon starvation protein
HC662_28050	COG1695	Transcriptional regulator
HC662_28060	COG3534	alpha-L-arabinofuranosidase
HC662_28070	COG0395	ABC-type sugar transport system, permease component
HC662_28080	COG1175	transmembrane transport
HC662_28090	COG1653	transport
HC662_28100	COG0371	Dehydrogenase
HC662_28110	COG0647	UMP catabolic process
HC662_28120	COG0235	Class ii aldolase
HC662_28130	COG1069	ribulokinase activity
HC662_28140	COG2160	L-arabinose isomerase activity
HC662_28150	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_28160	COG1363	Peptidase, m42
HC662_28180	COG3326	Membrane
HC662_28190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC662_28200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC662_28210	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC662_28220	COG1346	cytolysis
HC662_28230	COG1380	Effector of murein hydrolase LrgA
HC662_28240	COG3279	Response regulator of the LytR AlgR family
HC662_28250	COG3275	phosphorelay sensor kinase activity
HC662_28260	COG1011	Hydrolase
HC662_28270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC662_28290	COG0398	Pfam SNARE associated Golgi protein
HC662_28300	COG1484	DNA-dependent DNA replication
HC662_28310	COG3611	Membrane attachment protein
HC662_28320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC662_28330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HC662_28340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC662_28350	COG1733	regulation of RNA biosynthetic process
HC662_28360	COG2814	Major facilitator Superfamily
HC662_28370	COG0656	L-ascorbic acid biosynthetic process
HC662_28380	COG0237	dephospho-CoA kinase activity
HC662_28390	COG1971	Probably functions as a manganese efflux pump
HC662_28400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC662_28410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC662_28410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC662_28420	COG5002	protein histidine kinase activity
HC662_28430	COG0745	RESPONSE REGULATOR receiver
HC662_28440	COG0039	L-malate dehydrogenase activity
HC662_28450	COG0538	isocitrate dehydrogenase activity
HC662_28460	COG0372	Belongs to the citrate synthase family
HC662_28470	COG2707	UPF0756 membrane protein
HC662_28480	COG0628	permease
HC662_28490	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC662_28500	COG0469	pyruvate kinase activity
HC662_28510	COG0205	6-phosphofructokinase activity
HC662_28520	COG0825	malonyl-CoA metabolic process
HC662_28530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC662_28540	COG0281	malic enzyme
HC662_28550	COG0587	DNA-directed DNA polymerase activity
HC662_28590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC662_28610	COG4109	DRTGG domain
HC662_28620	COG0730	response to heat
HC662_28630	COG1473	amidohydrolase
HC662_28640	COG0196	riboflavin kinase activity
HC662_28650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_28660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_28670	COG0454	-acetyltransferase
HC662_28680	COG0583	DNA-binding transcription factor activity
HC662_28700	COG1714	RDD family
HC662_28710	COG0616	signal peptide processing
HC662_28720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC662_28730	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HC662_28740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC662_28760	COG0301	tRNA thio-modification
HC662_28770	COG1104	cysteine desulfurase activity
HC662_28780	COG1114	Component of the transport system for branched-chain amino acids
HC662_28790	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HC662_28800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC662_28810	COG1309	transcriptional regulator
HC662_28820	COG1956	GAF domain-containing protein
HC662_28830	COG2203	Gaf domain
HC662_28830	COG2199	diguanylate cyclase activity
HC662_28850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC662_28860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC662_28870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC662_28880	COG0454	-acetyltransferase
HC662_28890	COG0517	IMP dehydrogenase activity
HC662_28900	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC662_28910	COG1360	Flagellar Motor Protein
HC662_28920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC662_28930	COG1609	Transcriptional regulator
HC662_28940	COG1605	Chorismate mutase
HC662_28940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC662_28950	COG3118	belongs to the thioredoxin family
HC662_28960	COG4980	gas vesicle protein
HC662_28970	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC662_28980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC662_28990	COG1674	ftsk spoiiie
HC662_29000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC662_29010	COG4848	Belongs to the UPF0354 family
HC662_29020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_29040	COG1363	Peptidase, m42
HC662_29050	COG5584	Small secreted protein
HC662_29060	COG0281	malic enzyme
HC662_29070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC662_29080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC662_29100	COG0510	thiamine kinase activity
HC662_29110	COG1523	belongs to the glycosyl hydrolase 13 family
HC662_29120	COG1597	lipid kinase activity
HC662_29140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC662_29150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC662_29160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_29170	COG2252	PERMEase
HC662_29180	COG4473	ABC transporter
HC662_29190	COG1131	(ABC) transporter
HC662_29200	COG1349	DNA-binding transcription factor activity
HC662_29210	COG1187	pseudouridine synthase activity
HC662_29220	COG2244	polysaccharide biosynthetic process
HC662_29230	COG2081	HI0933 family
HC662_29240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC662_29260	COG5578	integral membrane protein
HC662_29270	COG0673	inositol 2-dehydrogenase activity
HC662_29280	COG1653	transport
HC662_29290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC662_29300	COG4209	transmembrane transport
HC662_29310	COG2207	Transcriptional regulator
HC662_29320	COG1653	transport
HC662_29330	COG0395	ABC-type sugar transport system, permease component
HC662_29340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_29350	COG2124	cytochrome p450
HC662_29360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HC662_29380	COG0156	8-amino-7-oxononanoate synthase activity
HC662_29390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC662_29400	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HC662_29420	COG1073	alpha beta
HC662_29430	COG1609	Transcriptional regulator
HC662_29440	COG1653	transport
HC662_29450	COG1175	transmembrane transport
HC662_29460	COG0395	ABC-type sugar transport system, permease component
HC662_29470	COG1486	melibiose metabolic process
HC662_29480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_29490	COG0495	leucyl-tRNA aminoacylation
HC662_29510	COG1366	Belongs to the anti-sigma-factor antagonist family
HC662_29510	COG2202	Pas domain
HC662_29520	COG2814	Major facilitator Superfamily
HC662_29530	COG2433	Pfam Transposase IS66
HC662_29540	COG0577	efflux transmembrane transporter activity
HC662_29550	COG1136	(ABC) transporter
HC662_29560	COG2205	protein histidine kinase activity
HC662_29570	COG0745	RESPONSE REGULATOR receiver
HC662_29580	COG0577	efflux transmembrane transporter activity
HC662_29590	COG1136	(ABC) transporter
HC662_29620	COG1131	(ABC) transporter
HC662_29630	COG1725	Transcriptional regulator
HC662_29650	COG1242	4 iron, 4 sulfur cluster binding
HC662_29660	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC662_29680	COG2267	carboxylic ester hydrolase activity
HC662_29690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC662_29700	COG1113	amino acid transport
HC662_29710	COG0367	asparagine synthase
HC662_29720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC662_29730	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HC662_29750	COG1506	peptidase
HC662_29760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC662_29770	COG1116	anion transmembrane transporter activity
HC662_29780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC662_29790	COG0494	nUDIX hydrolase
HC662_29800	COG4824	toxin secretion phage lysis holin
HC662_29810	COG0783	Belongs to the Dps family
HC662_29830	COG1854	S-ribosylhomocysteine lyase activity
HC662_29840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC662_29850	COG0288	reversible hydration of carbon dioxide
HC662_29860	COG0254	rRNA binding
HC662_29870	COG1271	oxidase subunit
HC662_29880	COG1294	oxidase, subunit
HC662_29900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC662_29910	COG1321	iron dependent repressor
HC662_29910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC662_29920	COG1121	(ABC) transporter
HC662_29930	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC662_29940	COG4948	Mandelate Racemase Muconate Lactonizing
HC662_29950	COG0318	PFAM AMP-dependent synthetase and ligase
HC662_29960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC662_29970	COG0596	Alpha beta hydrolase
HC662_29980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HC662_29990	COG1169	isochorismate synthase
HC662_30000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC662_30010	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC662_30020	COG0058	SHG alpha-glucan phosphorylase activity
HC662_30030	COG0297	glycogen (starch) synthase activity
HC662_30040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC662_30050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC662_30060	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC662_30310	COG3859	Proton-coupled thiamine transporter YuaJ
HC662_30320	COG1247	-acetyltransferase
HC662_30330	COG2268	Band 7 protein
HC662_30340	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC662_30350	COG2318	DinB family
HC662_30370	COG1454	alcohol dehydrogenase
HC662_30380	COG1012	belongs to the aldehyde dehydrogenase family
HC662_30390	COG1510	regulation of RNA biosynthetic process
HC662_30410	COG0569	domain protein
HC662_30420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC662_30430	COG4682	membrane
HC662_30440	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC662_30450	COG0477	Major facilitator Superfamily
HC662_30460	COG5553	Cysteine dioxygenase type I
HC662_30480	COG1968	undecaprenyl-diphosphatase activity
HC662_30490	COG0628	permease
HC662_30500	COG0673	inositol 2-dehydrogenase activity
HC662_30510	COG4806	L-rhamnose isomerase
HC662_30520	COG3254	rhamnose metabolic process
HC662_30530	COG1070	Carbohydrate kinase
HC662_30540	COG1349	DNA-binding transcription factor activity
HC662_30550	COG3347	Dehydrogenase
HC662_30550	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_30560	COG0840	transmembrane signaling receptor activity
HC662_30570	COG0840	transmembrane signaling receptor activity
HC662_30580	COG0840	transmembrane signaling receptor activity
HC662_30590	COG0840	transmembrane signaling receptor activity
HC662_30620	COG2070	2-Nitropropane dioxygenase
HC662_30630	COG0432	Pfam Uncharacterised protein family UPF0047
HC662_30640	COG0366	Alpha amylase catalytic
HC662_30650	COG1253	flavin adenine dinucleotide binding
HC662_30660	COG2738	Putative neutral zinc metallopeptidase
HC662_30690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC662_30720	COG0166	Belongs to the GPI family
HC662_30730	COG1979	alcohol dehydrogenase
HC662_30740	COG1979	alcohol dehydrogenase
HC662_30750	COG2155	Conserved Protein
HC662_30760	COG1098	S1 RNA binding domain
HC662_30780	COG0436	Aminotransferase
HC662_30790	COG1522	sequence-specific DNA binding
HC662_30800	COG2267	carboxylic ester hydrolase activity
HC662_30820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC662_30830	COG2205	protein histidine kinase activity
HC662_30850	COG5018	Exonuclease
HC662_30870	COG2814	Major facilitator Superfamily
HC662_30880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC662_30890	COG3011	Protein conserved in bacteria
HC662_30910	COG3290	protein histidine kinase activity
HC662_30920	COG4565	transcriptional regulatory protein
HC662_30970	COG3493	citrate carrier protein
HC662_30990	COG2111	Na H antiporter
HC662_30990	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC662_31000	COG2111	Na H antiporter
HC662_31010	COG1006	Multisubunit Na H antiporter MnhC subunit
HC662_31020	COG0651	ATP synthesis coupled electron transport
HC662_31030	COG1863	multisubunit Na H antiporter MnhE subunit
HC662_31040	COG2212	antiporter activity
HC662_31050	COG1320	monovalent cation:proton antiporter activity
HC662_31060	COG2050	protein possibly involved in aromatic compounds catabolism
HC662_31070	COG2197	response regulator
HC662_31080	COG4585	Histidine kinase
HC662_31100	COG0142	geranyltranstransferase activity
HC662_31120	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC662_31130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC662_31140	COG1335	isochorismatase
HC662_31150	COG5506	Protein of unknown function (DUF1694)
HC662_31180	COG0628	permease
HC662_31210	COG1418	mRNA catabolic process
HC662_31220	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_31240	COG1511	domain protein
HC662_31250	COG1674	ftsk spoiiie
HC662_31250	COG0433	COG0433 Predicted ATPase
HC662_31260	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC662_31270	COG5417	Belongs to the EsaB family
HC662_31280	COG4842	Belongs to the WXG100 family
HC662_31300	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC662_31300	COG2508	Transcriptional regulator
HC662_31310	COG0686	Belongs to the AlaDH PNT family
HC662_31320	COG5634	Uncharacterized conserved protein (DUF2278)
HC662_31330	COG3251	PFAM MbtH domain protein
HC662_31340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_31350	COG3433	isochorismatase activity
HC662_31350	COG1535	isochorismatase
HC662_31360	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC662_31370	COG1169	isochorismate synthase
HC662_31380	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_31390	COG2819	hydrolase of the alpha beta superfamily
HC662_31400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC662_31410	COG1268	BioY protein
HC662_31420	COG2056	Na+-H+ antiporter family
HC662_31430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC662_31440	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HC662_31450	COG3584	3D domain protein
HC662_31470	COG1252	NADH dehydrogenase
HC662_31480	COG0492	ferredoxin-NADP+ reductase activity
HC662_31500	COG0516	GMP reductase activity
HC662_31510	COG2808	Putative FMN-binding domain
HC662_31520	COG0456	acetyltransferase
HC662_31530	COG0316	Belongs to the HesB IscA family
HC662_31540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC662_31550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC662_31560	COG4844	belongs to the
HC662_31570	COG1252	NADH dehydrogenase
HC662_31580	COG4837	Protein of unknown function (DUF1462)
HC662_31590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HC662_31600	COG4946	Tricorn protease homolog
HC662_31600	COG1506	peptidase
HC662_31600	COG0823	Involved in the tonB-independent uptake of proteins
HC662_31610	COG0083	homoserine kinase activity
HC662_31620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC662_31630	COG0460	homoserine dehydrogenase
HC662_31640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC662_31650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC662_31660	COG0647	UMP catabolic process
HC662_31670	COG2445	Protein of unknown function DUF86
HC662_31680	COG4470	Protein conserved in bacteria
HC662_31700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC662_31710	COG0739	heme binding
HC662_31730	COG3377	Domain of unknown function (DUF1805)
HC662_31740	COG0737	Belongs to the 5'-nucleotidase family
HC662_31750	COG0730	response to heat
HC662_31760	COG1801	Protein of unknown function DUF72
HC662_31780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC662_31790	COG2508	Transcriptional regulator
HC662_31800	COG2233	PERMEase
HC662_31810	COG2233	PERMEase
HC662_31820	COG3648	Uricase
HC662_31820	COG3195	allantoin biosynthetic process
HC662_31830	COG2351	hydroxyisourate hydrolase activity
HC662_31860	COG2080	2 iron, 2 sulfur cluster binding
HC662_31870	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC662_31890	COG0457	Tetratricopeptide repeat
HC662_31900	COG5444	nuclease activity
HC662_31930	COG2080	2 iron, 2 sulfur cluster binding
HC662_31940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC662_31950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC662_31960	COG2068	MobA-Related Protein
HC662_31970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC662_31980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC662_31990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC662_32000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC662_32010	COG2356	endonuclease I
HC662_32020	COG3842	ATPase activity
HC662_32030	COG2188	Transcriptional regulator
HC662_32040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_32050	COG0395	ABC-type sugar transport system, permease component
HC662_32060	COG1175	transmembrane transport
HC662_32070	COG1653	transport
HC662_32080	COG2222	sugar isomerase
HC662_32090	COG0322	excinuclease ABC activity
HC662_32100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC662_32130	COG0346	lactoylglutathione lyase activity
HC662_32140	COG0719	Fe-S assembly protein
HC662_32150	COG0822	iron-sulfur transferase activity
HC662_32160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC662_32170	COG0719	Fe-S assembly protein
HC662_32180	COG0396	ATPase activity
HC662_32190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC662_32200	COG1464	Belongs to the NlpA lipoprotein family
HC662_32210	COG2011	ABC-type metal ion transport system permease component
HC662_32220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC662_32240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC662_32250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC662_32270	COG0509	glycine decarboxylation via glycine cleavage system
HC662_32280	COG1393	Belongs to the ArsC family
HC662_32290	COG1960	acyl-CoA dehydrogenase activity
HC662_32300	COG0183	Belongs to the thiolase family
HC662_32310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC662_32310	COG1024	Enoyl-CoA hydratase
HC662_32320	COG0506	proline dehydrogenase activity
HC662_32340	COG5577	PFAM Coat F domain
HC662_32350	COG1846	Transcriptional regulator
HC662_32360	COG0477	Major facilitator Superfamily
HC662_32370	COG1942	4-Oxalocrotonate Tautomerase
HC662_32380	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_32390	COG0583	DNA-binding transcription factor activity
HC662_32410	COG1120	ATPase activity
HC662_32440	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_32450	COG0783	Belongs to the Dps family
HC662_32460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_32470	COG0745	RESPONSE REGULATOR receiver
HC662_32480	COG2205	protein histidine kinase activity
HC662_32480	COG2770	Histidine kinase
HC662_32500	COG1309	transcriptional regulator
HC662_32510	COG0114	fumarate hydratase activity
HC662_32530	COG0697	spore germination
HC662_32540	COG0814	amino acid
HC662_32560	COG2197	response regulator
HC662_32570	COG4585	Histidine kinase
HC662_32580	COG4758	membrane
HC662_32590	COG3595	metallopeptidase activity
HC662_32600	COG1842	Phage shock protein A
HC662_32610	COG4758	membrane
HC662_32620	COG2814	Major facilitator Superfamily
HC662_32630	COG2096	Adenosyltransferase
HC662_32640	COG1120	ATPase activity
HC662_32650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_32660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_32670	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_32680	COG3386	PFAM SMP-30 Gluconolaconase
HC662_32690	COG2205	protein histidine kinase activity
HC662_32700	COG0745	RESPONSE REGULATOR receiver
HC662_32720	COG1191	sigma factor activity
HC662_32740	COG2140	Oxalate decarboxylase
HC662_32760	COG0577	efflux transmembrane transporter activity
HC662_32770	COG1136	(ABC) transporter
HC662_32780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC662_32790	COG1120	ATPase activity
HC662_32800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_32810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC662_32820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_32830	COG0531	amino acid
HC662_32850	COG1988	membrane-bound metal-dependent
HC662_32860	COG1368	sulfuric ester hydrolase activity
HC662_32870	COG1910	domain protein
HC662_32880	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC662_32890	COG4149	molybdate abc transporter
HC662_32900	COG0656	L-ascorbic acid biosynthetic process
HC662_32920	COG0025	NhaP-type Na H and K H
HC662_32930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC662_32940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC662_32950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC662_32960	COG3973	AAA domain
HC662_32970	COG2860	membrane
HC662_32980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC662_32990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC662_33000	COG2217	Heavy metal translocating P-type atpase
HC662_33010	COG2217	Heavy metal translocating P-type atpase
HC662_33020	COG2608	mercury ion transmembrane transporter activity
HC662_33030	COG1937	Protein conserved in bacteria
HC662_33040	COG0673	inositol 2-dehydrogenase activity
HC662_33050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC662_33060	COG1289	transmembrane transporter activity
HC662_33090	COG2076	Multidrug Resistance protein
HC662_33100	COG1309	transcriptional regulator
HC662_33110	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_33120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC662_33130	COG0557	exoribonuclease II activity
HC662_33140	COG1647	Serine aminopeptidase, S33
HC662_33150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC662_33160	COG0596	Alpha beta hydrolase
HC662_33170	COG1476	TRANSCRIPTIONal
HC662_33180	COG1396	sequence-specific DNA binding
HC662_33190	COG1396	sequence-specific DNA binding
HC662_33200	COG1733	regulation of RNA biosynthetic process
HC662_33250	COG1174	glycine betaine transport
HC662_33260	COG1732	Glycine betaine
HC662_33270	COG1174	glycine betaine transport
HC662_33280	COG0517	IMP dehydrogenase activity
HC662_33280	COG1125	glycine betaine transport
HC662_33290	COG1510	regulation of RNA biosynthetic process
HC662_33300	COG1174	glycine betaine transport
HC662_33310	COG1732	Glycine betaine
HC662_33320	COG1174	glycine betaine transport
HC662_33330	COG1125	glycine betaine transport
HC662_33330	COG0517	IMP dehydrogenase activity
HC662_33340	COG1510	regulation of RNA biosynthetic process
HC662_33360	COG3064	Membrane
HC662_33370	COG4640	response to antibiotic
HC662_33380	COG0456	acetyltransferase
HC662_33400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HC662_33420	COG0126	phosphoglycerate kinase activity
HC662_33430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC662_33440	COG2390	Transcriptional regulator
HC662_33450	COG2814	Major facilitator Superfamily
HC662_33460	COG1609	Transcriptional regulator
HC662_33470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_33480	COG0583	DNA-binding transcription factor activity
HC662_33490	COG0697	spore germination
HC662_33500	COG1113	amino acid transport
HC662_33510	COG3858	chitin binding
HC662_33520	COG1556	Lactate utilization protein
HC662_33530	COG1139	Iron-sulfur cluster binding protein
HC662_33540	COG0247	lactate metabolic process
HC662_33550	COG2197	response regulator
HC662_33560	COG4585	Histidine kinase
HC662_33570	COG0842	Transport permease protein
HC662_33580	COG1131	(ABC) transporter
HC662_33590	COG0596	Alpha beta hydrolase
HC662_33600	COG2208	phosphoserine phosphatase activity
HC662_33610	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC662_33620	COG1874	Beta-galactosidase
HC662_33630	COG3833	ABC-type maltose transport systems, permease component
HC662_33640	COG1175	transmembrane transport
HC662_33650	COG2182	Extracellular solute-binding protein
HC662_33660	COG1609	Transcriptional regulator
HC662_33670	COG2186	Transcriptional regulator
HC662_33680	COG1620	l-lactate permease
HC662_33690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC662_33710	COG5039	Polysaccharide pyruvyl transferase
HC662_33720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC662_33730	COG0110	maltose O-acetyltransferase activity
HC662_33740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC662_33750	COG2244	polysaccharide biosynthetic process
HC662_33760	COG1216	Glycosyl transferase, family 2
HC662_33770	COG5039	Polysaccharide pyruvyl transferase
HC662_33780	COG1216	Glycosyl transferase, family 2
HC662_33800	COG0438	transferase activity, transferring glycosyl groups
HC662_33810	COG1215	transferase activity, transferring glycosyl groups
HC662_33820	COG0438	transferase activity, transferring glycosyl groups
HC662_33830	COG1086	Polysaccharide biosynthesis protein
HC662_33840	COG0489	protein tyrosine kinase activity
HC662_33850	COG3944	biosynthesis protein
HC662_33860	COG1396	sequence-specific DNA binding
HC662_33870	COG2272	Belongs to the type-B carboxylesterase lipase family
HC662_33890	COG3479	Phenolic acid decarboxylase
HC662_33910	COG1794	racemase activity, acting on amino acids and derivatives
HC662_33920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC662_33930	COG1621	beta-fructofuranosidase activity
HC662_33940	COG1621	beta-fructofuranosidase activity
HC662_33950	COG0531	amino acid
HC662_33960	COG1309	transcriptional regulator
HC662_33970	COG2076	Multidrug Resistance protein
HC662_33980	COG2076	Multidrug Resistance protein
HC662_34020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC662_34030	COG0366	Alpha amylase catalytic
HC662_34040	COG1554	hydrolase, family 65, central catalytic
HC662_34050	COG5521	maltodextrose utilization protein MalA
HC662_34060	COG3833	ABC-type maltose transport systems, permease component
HC662_34070	COG1175	transmembrane transport
HC662_34080	COG2272	Belongs to the type-B carboxylesterase lipase family
HC662_34100	COG3479	Phenolic acid decarboxylase
HC662_34120	COG1794	racemase activity, acting on amino acids and derivatives
HC662_34130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC662_34140	COG1621	beta-fructofuranosidase activity
HC662_34150	COG1621	beta-fructofuranosidase activity
HC662_34160	COG0531	amino acid
HC662_34170	COG1309	transcriptional regulator
HC662_34180	COG2076	Multidrug Resistance protein
HC662_34210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC662_34220	COG0366	Alpha amylase catalytic
HC662_34230	COG1554	hydrolase, family 65, central catalytic
HC662_34240	COG5521	maltodextrose utilization protein MalA
HC662_34250	COG3833	ABC-type maltose transport systems, permease component
HC662_34260	COG1175	transmembrane transport
HC662_34270	COG2182	Extracellular solute-binding protein
HC662_34280	COG0366	Alpha amylase catalytic
HC662_34290	COG1609	Transcriptional regulator
HC662_34300	COG1611	Belongs to the LOG family
HC662_34310	COG1694	Mazg nucleotide pyrophosphohydrolase
HC662_34320	COG0659	secondary active sulfate transmembrane transporter activity
HC662_34330	COG0288	reversible hydration of carbon dioxide
HC662_34340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC662_34350	COG0577	efflux transmembrane transporter activity
HC662_34360	COG1136	(ABC) transporter
HC662_34370	COG5002	protein histidine kinase activity
HC662_34380	COG0745	RESPONSE REGULATOR receiver
HC662_34400	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC662_34410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_34420	COG1481	regulation of sporulation
HC662_34430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC662_34440	COG1660	Displays ATPase and GTPase activities
HC662_34450	COG1051	belongs to the nudix hydrolase family
HC662_34460	COG0492	ferredoxin-NADP+ reductase activity
HC662_34470	COG0791	NLP P60 protein
HC662_34470	COG3883	PFAM NLP P60 protein
HC662_34480	COG0457	Tetratricopeptide repeat
HC662_34490	COG1132	(ABC) transporter
HC662_34500	COG0140	phosphoribosyl-ATP diphosphatase activity
HC662_34500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC662_34510	COG0107	imidazoleglycerol-phosphate synthase activity
HC662_34520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC662_34530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC662_34540	COG0131	Imidazoleglycerol-phosphate dehydratase
HC662_34550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC662_34560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC662_34570	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HC662_34580	COG4990	cell redox homeostasis
HC662_34590	COG5297	Belongs to the glycosyl hydrolase family 6
HC662_34600	COG0110	maltose O-acetyltransferase activity
HC662_34610	COG0546	phosphoglycolate phosphatase activity
HC662_34620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HC662_34630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC662_34640	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC662_34650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC662_34660	COG0363	glucosamine-6-phosphate deaminase activity
HC662_34670	COG2188	Transcriptional regulator
HC662_34680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC662_34690	COG1846	Transcriptional regulator
HC662_34700	COG2814	Major facilitator Superfamily
HC662_34710	COG1950	PFAM Membrane protein of
HC662_34720	COG1983	PspC domain protein
HC662_34730	COG3595	metallopeptidase activity
HC662_34760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC662_34770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC662_34780	COG0556	nucleotide-excision repair
HC662_34790	COG4897	Protein conserved in bacteria
HC662_34810	COG0574	Belongs to the PEP-utilizing enzyme family
HC662_34810	COG3848	Pyruvate phosphate dikinase
HC662_34820	COG1309	transcriptional regulator
HC662_34830	COG2814	Major facilitator Superfamily
HC662_34840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_34860	COG3409	Peptidoglycan-binding domain 1 protein
HC662_34860	COG0793	Belongs to the peptidase S41A family
HC662_34870	COG2177	Part of the ABC transporter FtsEX involved in
HC662_34880	COG2884	Cell division ATP-binding protein ftsE
HC662_34890	COG2010	Cytochrome c
HC662_34900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_34910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HC662_34920	COG0653	protein targeting
HC662_34930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC662_34960	COG1516	flagellar protein fliS
HC662_34970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HC662_34980	COG1334	flagellar protein FlaG
HC662_34990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC662_35000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC662_35010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HC662_35030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC662_35040	COG4786	Flagellar basal body rod
HC662_35040	COG1256	bacterial-type flagellum assembly
HC662_35050	COG3418	PFAM FlgN family protein
HC662_35060	COG2747	anti-sigma28 factor FlgM
HC662_35080	COG1040	competence protein
HC662_35100	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HC662_35110	COG1307	EDD domain protein, DegV family
HC662_35120	COG2197	response regulator
HC662_35130	COG4585	Histidine kinase
HC662_35140	COG1739	Uncharacterized protein family UPF0029
HC662_35150	COG1316	TRANSCRIPTIONal
HC662_35160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC662_35170	COG0438	transferase activity, transferring glycosyl groups
HC662_35180	COG1215	transferase activity, transferring glycosyl groups
HC662_35190	COG3206	protein involved in exopolysaccharide biosynthesis
HC662_35200	COG3307	-O-antigen
HC662_35210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC662_35220	COG0438	transferase activity, transferring glycosyl groups
HC662_35220	COG0297	glycogen (starch) synthase activity
HC662_35230	COG2244	polysaccharide biosynthetic process
HC662_35260	COG2247	cell wall binding repeat
HC662_35260	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC662_35270	COG2247	cell wall binding repeat
HC662_35270	COG2385	sporulation resulting in formation of a cellular spore
HC662_35290	COG1316	TRANSCRIPTIONal
HC662_35300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC662_35340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC662_35350	COG1134	teichoic acid transport
HC662_35360	COG1682	transport, permease protein
HC662_35370	COG1216	Glycosyl transferase, family 2
HC662_35370	COG1442	glycosyl transferase family 8
HC662_35390	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC662_35400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC662_35400	COG0463	Glycosyl transferase, family 2
HC662_35430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC662_35450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC662_35520	COG4193	domain, Protein
HC662_35530	COG1482	cell wall glycoprotein biosynthetic process
HC662_35540	COG0697	spore germination
HC662_35550	COG0814	amino acid
HC662_35570	COG2814	Major facilitator Superfamily
HC662_35580	COG1316	TRANSCRIPTIONal
HC662_35590	COG0561	phosphatase activity
HC662_35600	COG0791	NLP P60 protein
HC662_35620	COG2843	Capsule synthesis protein
HC662_35640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC662_35650	COG1609	Transcriptional regulator
HC662_35660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_35670	COG1869	D-ribose catabolic process
HC662_35680	COG1129	ABC transporter
HC662_35690	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC662_35700	COG1879	ABC-type sugar transport system periplasmic component
HC662_35710	COG3103	Sh3 type 3 domain protein
HC662_35730	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC662_35740	COG3527	Alpha-acetolactate decarboxylase
HC662_35750	COG0028	Belongs to the TPP enzyme family
HC662_35760	COG0583	DNA-binding transcription factor activity
HC662_35770	COG5337	Spore coat protein CotH
HC662_35790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC662_35810	COG0405	Gamma-glutamyltransferase
HC662_35820	COG1522	sequence-specific DNA binding
HC662_35830	COG2059	Chromate
HC662_35840	COG2059	Chromate
HC662_35880	COG5444	nuclease activity
HC662_35910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC662_35920	COG4464	protein tyrosine phosphatase activity
HC662_35930	COG0489	protein tyrosine kinase activity
HC662_35940	COG3944	biosynthesis protein
HC662_35950	COG4715	Zinc finger, swim domain protein
HC662_35960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC662_35970	COG0561	phosphatase activity
HC662_35980	COG1349	DNA-binding transcription factor activity
HC662_35990	COG0629	single-stranded DNA binding
HC662_36020	COG2602	Beta-lactamase
HC662_36030	COG3764	Sortase (surface protein transpeptidase)
HC662_36050	COG3279	Response regulator of the LytR AlgR family
HC662_36060	COG0745	RESPONSE REGULATOR receiver
HC662_36060	COG2972	Histidine kinase
HC662_36070	COG1970	mechanosensitive ion channel activity
HC662_36080	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC662_36090	COG0457	Tetratricopeptide repeat
HC662_36100	COG4786	Flagellar basal body rod
HC662_36110	COG4786	Flagellar basal body rod
HC662_36120	COG1077	Cell shape determining protein MreB Mrl
HC662_36130	COG1609	Transcriptional regulator
HC662_36140	COG1846	Transcriptional regulator
HC662_36150	COG2814	Major facilitator Superfamily
HC662_36160	COG3420	alginic acid biosynthetic process
HC662_36170	COG1953	Uracil, thiamine, allantoin
HC662_36180	COG0477	Major facilitator Superfamily
HC662_36190	COG1335	isochorismatase
HC662_36210	COG0004	ammonium transporteR
HC662_36220	COG0347	Belongs to the P(II) protein family
HC662_36230	COG0671	phosphoesterase, PA-phosphatase related
HC662_36250	COG0739	heme binding
HC662_36260	COG1247	-acetyltransferase
HC662_36280	COG1086	Polysaccharide biosynthesis protein
HC662_36290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC662_36300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC662_36310	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HC662_36340	COG2089	acid synthase
HC662_36360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC662_36370	COG0789	Transcriptional regulator
HC662_36390	COG2910	NAD(P)H-binding
HC662_36400	COG1959	2 iron, 2 sulfur cluster binding
HC662_36410	COG0804	urea catabolic process
HC662_36420	COG0832	Belongs to the urease beta subunit family
HC662_36430	COG0831	urea catabolic process
HC662_36490	COG3237	CsbD-like
HC662_36500	COG1994	Peptidase M50
HC662_36510	COG0457	Tetratricopeptide repeat
HC662_36520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC662_36530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC662_36550	COG2304	oxidoreductase activity
HC662_36560	COG2304	oxidoreductase activity
HC662_36570	COG2385	sporulation resulting in formation of a cellular spore
HC662_36580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC662_36600	COG4836	Membrane
HC662_36630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC662_36640	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC662_36650	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC662_36660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC662_36670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC662_36690	COG0356	it plays a direct role in the translocation of protons across the membrane
HC662_36710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC662_36720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC662_36730	COG4475	Protein of unknown function (DUF436)
HC662_36740	COG0698	ribose 5-phosphate isomerase
HC662_36750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC662_36760	COG1971	Probably functions as a manganese efflux pump
HC662_36770	COG0009	L-threonylcarbamoyladenylate synthase
HC662_36780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC662_36820	COG2890	protein-(glutamine-N5) methyltransferase activity
HC662_36830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC662_36840	COG0346	lactoylglutathione lyase activity
HC662_36850	COG0789	Transcriptional regulator
HC662_36860	COG0679	Auxin Efflux Carrier
HC662_36870	COG0281	malic enzyme
HC662_36880	COG1435	thymidine kinase activity
HC662_36900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC662_36920	COG1494	fructose-1,6-bisphosphatase
HC662_36930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC662_36940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC662_36950	COG0191	fructose-bisphosphate aldolase activity
HC662_36960	COG2204	response regulator
HC662_36970	COG4821	SIS domain
HC662_36980	COG0504	CTP synthase activity
HC662_36990	COG3343	RNA polymerase activity
HC662_37000	COG1960	acyl-CoA dehydrogenase activity
HC662_37010	COG2181	nitrate reductase activity
HC662_37010	COG0247	lactate metabolic process
HC662_37020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC662_37030	COG4294	response to UV
HC662_37050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC662_37060	COG1132	(ABC) transporter
HC662_37070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC662_37090	COG2181	nitrate reductase activity
HC662_37100	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC662_37110	COG1140	nitrate reductase beta subunit
HC662_37120	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC662_37130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC662_37150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC662_37160	COG2223	nitrite transmembrane transporter activity
HC662_37170	COG0018	arginyl-trna synthetase
HC662_37180	COG4506	Protein conserved in bacteria
HC662_37200	COG0535	radical SAM domain protein
HC662_37220	COG1131	(ABC) transporter
HC662_37240	COG0612	Peptidase, M16
HC662_37270	COG3391	amine dehydrogenase activity
HC662_37280	COG3391	amine dehydrogenase activity
HC662_37290	COG0457	Tetratricopeptide repeat
HC662_37350	COG1131	(ABC) transporter
HC662_37370	COG0010	Belongs to the arginase family
HC662_37380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC662_37390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC662_37400	COG0740	serine-type endopeptidase activity
HC662_37470	COG1994	Peptidase M50
HC662_37480	COG1942	4-Oxalocrotonate Tautomerase
HC662_37490	COG1846	Transcriptional regulator
HC662_37500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC662_37510	COG0477	Major facilitator Superfamily
HC662_37520	COG1959	2 iron, 2 sulfur cluster binding
HC662_37530	COG3465	dGTPase activity
HC662_37540	COG1078	dGTPase activity
HC662_37550	COG4844	belongs to the
HC662_37570	COG0697	spore germination
HC662_37580	COG0095	Lipoate-protein ligase
HC662_37590	COG0583	DNA-binding transcription factor activity
HC662_37600	COG0280	phosphate acetyltransferase
HC662_37620	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_37630	COG0436	Aminotransferase
HC662_37640	COG2814	Major facilitator Superfamily
HC662_37650	COG0151	Belongs to the GarS family
HC662_37660	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_37670	COG1917	Cupin 2, conserved barrel domain protein
HC662_37680	COG0077	Prephenate dehydratase
HC662_37690	COG2814	Major facilitator Superfamily
HC662_37700	COG0833	amino acid
HC662_37710	COG4187	Peptidase family M20/M25/M40
HC662_37720	COG1012	belongs to the aldehyde dehydrogenase family
HC662_37730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC662_37750	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC662_37760	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC662_37770	COG1088	dTDP-glucose 4,6-dehydratase activity
HC662_37780	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC662_37790	COG0456	acetyltransferase
HC662_37800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC662_37810	COG0463	Glycosyl transferase, family 2
HC662_37830	COG2363	Small membrane protein
HC662_37840	COG2233	PERMEase
HC662_37860	COG1012	belongs to the aldehyde dehydrogenase family
HC662_37870	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC662_37880	COG1216	Glycosyl transferase, family 2
HC662_37890	COG0351	phosphomethylpyrimidine kinase
HC662_37910	COG1621	beta-fructofuranosidase activity
HC662_37920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_37920	COG1263	PTS System
HC662_37930	COG2116	formate transmembrane transporter activity
HC662_37940	COG3711	transcriptional antiterminator
HC662_37960	COG1404	Belongs to the peptidase S8 family
HC662_37970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_37980	COG0778	Nitroreductase
HC662_37990	COG0772	Belongs to the SEDS family
HC662_38020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC662_38060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC662_38070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC662_38080	COG2837	iron assimilation
HC662_38090	COG2822	iron ion transport
HC662_38100	COG0672	)-iron permease
HC662_38110	COG0352	thiamine-phosphate diphosphorylase activity
HC662_38120	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HC662_38130	COG0583	DNA-binding transcription factor activity
HC662_38140	COG1380	Effector of murein hydrolase LrgA
HC662_38150	COG1346	cytolysis
HC662_38160	COG2814	Major facilitator Superfamily
HC662_38170	COG4895	conserved protein (DUF2196)
HC662_38180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC662_38190	COG0346	lactoylglutathione lyase activity
HC662_38200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_38210	COG1404	Belongs to the peptidase S8 family
HC662_38220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_38220	COG1263	PTS System
HC662_38230	COG3711	transcriptional antiterminator
HC662_38240	COG1442	glycosyl transferase family 8
HC662_38250	COG5522	Integral membrane protein (intg_mem_TP0381)
HC662_38260	COG1846	Transcriptional regulator
HC662_38270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC662_38280	COG2234	aminopeptidase activity
HC662_38310	COG2814	Major facilitator Superfamily
HC662_38320	COG2357	RelA SpoT domain protein
HC662_38330	COG1575	Belongs to the MenA family. Type 1 subfamily
HC662_38350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC662_38360	COG1696	Membrane protein involved in D-alanine export
HC662_38370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC662_38380	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC662_38390	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC662_38400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC662_38410	COG1486	melibiose metabolic process
HC662_38420	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC662_38430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_38440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC662_38450	COG3711	transcriptional antiterminator
HC662_38450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC662_38470	COG2094	Belongs to the DNA glycosylase MPG family
HC662_38480	COG0753	catalase activity
HC662_38490	COG2814	Major facilitator Superfamily
HC662_38500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC662_38510	COG1131	(ABC) transporter
HC662_38550	COG1595	DNA-templated transcription, initiation
HC662_38560	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC662_38570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC662_38580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC662_38590	COG4988	ABC transporter
HC662_38600	COG1294	oxidase, subunit
HC662_38610	COG1271	oxidase subunit
HC662_38620	COG3493	citrate carrier protein
HC662_38630	COG0501	Belongs to the peptidase M48B family
HC662_38640	COG0726	polysaccharide deacetylase
HC662_38660	COG3842	ATPase activity
HC662_38670	COG2508	Transcriptional regulator
HC662_38680	COG1012	belongs to the aldehyde dehydrogenase family
HC662_38690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC662_38710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC662_38720	COG4585	Histidine kinase
HC662_38730	COG2197	response regulator
HC662_38740	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC662_38760	COG4894	glucomannan catabolic process
HC662_38770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC662_38780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC662_38790	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_38800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC662_38810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC662_38820	COG2610	gluconate transmembrane transporter activity
HC662_38830	COG0500	methyltransferase
HC662_38840	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_38850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC662_38880	COG0753	catalase activity
HC662_38880	COG0693	protein deglycase activity
HC662_38890	COG2851	Citrate transporter
HC662_38900	COG2323	membrane
HC662_38920	COG2273	Hydrolase Family 16
HC662_38930	COG2723	6-phospho-beta-galactosidase activity
HC662_38940	COG2190	(PTS) system
HC662_38940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_38940	COG1263	PTS System
HC662_38950	COG3711	transcriptional antiterminator
HC662_38970	COG2270	Major facilitator Superfamily
HC662_38980	COG0513	Belongs to the DEAD box helicase family
HC662_38990	COG3401	FG-GAP repeat protein
HC662_38990	COG2755	lipolytic protein G-D-S-L family
HC662_39030	COG0697	spore germination
HC662_39140	COG0697	spore germination
HC662_39160	COG0861	Integral membrane protein TerC family
HC662_39170	COG0589	response to stress
HC662_39180	COG2723	6-phospho-beta-galactosidase activity
HC662_39190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC662_39190	COG2190	(PTS) system
HC662_39190	COG1263	PTS System
HC662_39200	COG5444	nuclease activity
HC662_39260	COG3507	Belongs to the glycosyl hydrolase 43 family
HC662_39290	COG2986	histidine ammonia-lyase
HC662_39300	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC662_39310	COG1228	amidohydrolase
HC662_39320	COG0010	Belongs to the arginase family
HC662_39330	COG0833	amino acid
HC662_39340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC662_39350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC662_39360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC662_39370	COG2390	Transcriptional regulator
HC662_39390	COG3192	ethanolamine utilization protein
HC662_39400	COG2079	MmgE PrpD family protein
HC662_39410	COG1473	amidohydrolase
HC662_39420	COG1126	abc transporter atp-binding protein
HC662_39430	COG0765	amino acid transport
HC662_39440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_39450	COG0456	acetyltransferase
HC662_39460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_39470	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC662_39480	COG0561	phosphatase activity
HC662_39490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC662_39500	COG0456	acetyltransferase
HC662_39510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC662_39520	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC662_39530	COG0561	phosphatase activity
HC662_39580	COG5294	Protein conserved in bacteria
HC662_39590	COG0577	efflux transmembrane transporter activity
HC662_39600	COG1136	(ABC) transporter
HC662_39610	COG2205	protein histidine kinase activity
HC662_39620	COG0745	RESPONSE REGULATOR receiver
HC662_39640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC662_39650	COG0191	fructose-bisphosphate aldolase activity
HC662_39660	COG1082	Xylose isomerase domain protein TIM barrel
HC662_39670	COG1082	Xylose isomerase domain protein TIM barrel
HC662_39680	COG0673	inositol 2-dehydrogenase activity
HC662_39690	COG2814	Major facilitator Superfamily
HC662_39700	COG1082	Xylose isomerase domain protein TIM barrel
HC662_39710	COG3962	Belongs to the TPP enzyme family
HC662_39720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC662_39740	COG1012	belongs to the aldehyde dehydrogenase family
HC662_39750	COG1349	DNA-binding transcription factor activity
HC662_39760	COG0667	Aldo Keto reductase
HC662_39810	COG2814	Major facilitator Superfamily
HC662_39820	COG0326	Molecular chaperone. Has ATPase activity
HC662_39840	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_39850	COG1309	transcriptional regulator
HC662_39860	COG1012	belongs to the aldehyde dehydrogenase family
HC662_39870	COG1714	RDD family
HC662_39880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC662_39900	COG1714	RDD family
HC662_39910	COG2311	Membrane
HC662_39920	COG1917	Cupin 2, conserved barrel domain protein
HC662_39930	COG1309	transcriptional regulator
HC662_39940	COG1028	Short-chain dehydrogenase reductase Sdr
HC662_39950	COG1846	Transcriptional regulator
HC662_39960	COG1380	Effector of murein hydrolase LrgA
HC662_39970	COG1346	cytolysis
HC662_39980	COG5039	Polysaccharide pyruvyl transferase
HC662_39990	COG1929	Belongs to the glycerate kinase type-1 family
HC662_40000	COG1802	Transcriptional regulator
HC662_40010	COG1070	Carbohydrate kinase
HC662_40020	COG2610	gluconate transmembrane transporter activity
HC662_40030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC662_40040	COG0450	alkyl hydroperoxide reductase
HC662_40050	COG3634	alkyl hydroperoxide reductase activity
HC662_40090	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HC662_40100	COG0419	ATPase involved in DNA repair
HC662_40130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC662_40160	COG1063	alcohol dehydrogenase
HC662_40200	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC662_40210	COG0456	acetyltransferase
HC662_40220	COG0457	Tetratricopeptide repeat
HC662_40240	COG0010	Belongs to the arginase family
HC662_40250	COG0833	amino acid
HC662_40260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC662_40300	COG5658	integral membrane protein
HC662_40310	COG0640	Transcriptional regulator
HC662_40320	COG3829	transcription factor binding
HC662_40330	COG5002	protein histidine kinase activity
HC662_40360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC662_40370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC662_40380	COG4853	Protein conserved in bacteria
HC662_40390	COG4863	YycH protein
HC662_40400	COG5002	protein histidine kinase activity
HC662_40410	COG0745	RESPONSE REGULATOR receiver
HC662_40470	COG0346	lactoylglutathione lyase activity
HC662_40480	COG0305	Participates in initiation and elongation during chromosome replication
HC662_40510	COG3093	addiction module antidote protein HigA
HC662_40520	COG2807	transmembrane transport
HC662_40530	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC662_40540	COG0359	binds to the 23S rRNA
HC662_40550	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HC662_40560	COG4241	membrane
HC662_40580	COG5577	PFAM Coat F domain
HC662_40590	COG1733	regulation of RNA biosynthetic process
HC662_40600	COG1227	inorganic diphosphatase activity
HC662_40620	COG2271	Major facilitator Superfamily
HC662_40640	COG4319	ketosteroid isomerase
HC662_40650	COG1357	PFAM Pentapeptide repeats (8 copies)
HC662_40660	COG2814	Major facilitator Superfamily
HC662_40670	COG0583	DNA-binding transcription factor activity
HC662_40680	COG2153	protein acetylation
HC662_40700	COG0583	DNA-binding transcription factor activity
HC662_40710	COG1846	Transcriptional regulator
HC662_40720	COG2153	protein acetylation
HC662_40730	COG2364	Membrane
HC662_40750	COG1846	Transcriptional regulator
HC662_40760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC662_40780	COG0789	Transcriptional regulator
HC662_40790	COG0697	spore germination
HC662_40800	COG1331	Highly conserved protein containing a thioredoxin domain
HC662_40810	COG1266	CAAX protease self-immunity
HC662_40820	COG2814	Major facilitator Superfamily
HC662_40820	COG0477	Major facilitator Superfamily
HC662_40830	COG0346	lactoylglutathione lyase activity
HC662_40840	COG1609	Transcriptional regulator
HC662_40850	COG0708	Exodeoxyribonuclease III
HC662_40860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC662_40870	COG0629	single-stranded DNA binding
HC662_40880	COG0360	Binds together with S18 to 16S ribosomal RNA
HC662_40890	COG0012	GTP binding
HC662_40900	COG0243	molybdopterin cofactor binding
HC662_40910	COG4481	Protein conserved in bacteria
HC662_40920	COG3949	Membrane
HC662_40940	COG1475	DNA binding
HC662_40950	COG1192	Involved in chromosome partitioning
HC662_40970	COG1475	DNA binding
HC662_40980	COG0357	Ribosomal RNA small subunit methyltransferase G
HC662_40990	COG0445	tRNA wobble uridine modification
HC662_41000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HC662_41010	COG1847	R3H domain protein
HC662_41020	COG0706	membrane insertase activity
HC662_41030	COG0594	ribonuclease P activity