locus-tag	class	description
BEST7003_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BEST7003_0002	COG0592	DNA-directed DNA polymerase activity
BEST7003_0003	COG2501	S4 domain
BEST7003_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BEST7003_0006	COG0187	DNA topoisomerase II activity
BEST7003_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7003_0009	COG0517	IMP dehydrogenase activity
BEST7003_0009	COG0516	GMP reductase activity
BEST7003_0010	COG1686	Belongs to the peptidase S11 family
BEST7003_0011	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BEST7003_0012	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BEST7003_0013	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BEST7003_0014	COG1428	Deoxynucleoside kinase
BEST7003_0015	COG1428	Deoxynucleoside kinase
BEST7003_0016	COG3858	chitin binding
BEST7003_0016	COG1388	LysM domain
BEST7003_0017	COG1335	isochorismatase
BEST7003_0018	COG0590	tRNA wobble adenosine to inosine editing
BEST7003_0019	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BEST7003_0020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BEST7003_0021	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BEST7003_0025	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BEST7003_0026	COG3853	Toxic anion resistance protein (TelA)
BEST7003_0027	COG1982	Orn Lys Arg decarboxylase major
BEST7003_0028	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BEST7003_0029	COG3870	Protein conserved in bacteria
BEST7003_0030	COG1728	Protein conserved in bacteria
BEST7003_0031	COG0470	DNA polymerase III
BEST7003_0032	COG1774	PSP1 C-terminal conserved region
BEST7003_0033	COG4467	Involved in initiation control of chromosome replication
BEST7003_0034	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BEST7003_0035	COG2827	Endonuclease containing a URI domain
BEST7003_0036	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BEST7003_0037	COG2002	toxin-antitoxin pair type II binding
BEST7003_0038	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_0038	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_0039	COG0084	hydrolase, TatD family'
BEST7003_0040	COG3583	domain protein
BEST7003_0040	COG3584	3D domain protein
BEST7003_0041	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BEST7003_0042	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BEST7003_0044	COG4466	Protein conserved in bacteria
BEST7003_0046	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BEST7003_0047	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7003_0048	COG0251	oxidation-reduction process
BEST7003_0049	COG2088	sporulation resulting in formation of a cellular spore
BEST7003_0050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BEST7003_0051	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BEST7003_0052	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BEST7003_0053	COG0193	aminoacyl-tRNA hydrolase activity
BEST7003_0055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BEST7003_0056	COG2002	toxin-antitoxin pair type II binding
BEST7003_0057	COG2244	polysaccharide biosynthetic process
BEST7003_0058	COG3956	TIGRFAM MazG family protein
BEST7003_0059	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BEST7003_0062	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BEST7003_0063	COG1098	S1 RNA binding domain
BEST7003_0064	COG2208	phosphoserine phosphatase activity
BEST7003_0065	COG2304	oxidoreductase activity
BEST7003_0066	COG0515	serine threonine protein kinase
BEST7003_0067	COG0037	tRNA processing
BEST7003_0069	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7003_0070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BEST7003_0071	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BEST7003_0072	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BEST7003_0073	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7003_0074	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7003_0075	COG0512	Glutamine amidotransferase of anthranilate synthase
BEST7003_0076	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_0077	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BEST7003_0078	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BEST7003_0079	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BEST7003_0080	COG1396	sequence-specific DNA binding
BEST7003_0081	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7003_0082	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BEST7003_0083	COG4463	regulation of RNA biosynthetic process
BEST7003_0084	COG3880	PFAM UvrB UvrC protein
BEST7003_0085	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BEST7003_0086	COG0542	response to heat
BEST7003_0087	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BEST7003_0088	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BEST7003_0089	COG4956	integral membrane protein (PIN domain superfamily)
BEST7003_0090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BEST7003_0091	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BEST7003_0092	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BEST7003_0093	COG1045	serine acetyltransferase
BEST7003_0094	COG0215	cysteine-tRNA ligase activity
BEST7003_0095	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BEST7003_0096	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7003_0097	COG3688	RNA-binding protein containing a PIN domain
BEST7003_0098	COG1595	DNA-templated transcription, initiation
BEST7003_0099	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BEST7003_0100	COG0250	Participates in transcription elongation, termination and antitermination
BEST7003_0101	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BEST7003_0102	COG0081	regulation of translation
BEST7003_0103	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BEST7003_0104	COG0222	ribosome binding
BEST7003_0105	COG2813	Specifically methylates the guanine in position
BEST7003_0106	COG0085	RNA polymerase activity
BEST7003_0107	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BEST7003_0108	COG1358	cellular component organization or biogenesis
BEST7003_0109	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BEST7003_0110	COG0049	tRNA binding
BEST7003_0111	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BEST7003_0112	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BEST7003_0113	COG0596	Alpha beta hydrolase
BEST7003_0114	COG0051	transcription antitermination factor activity, RNA binding
BEST7003_0115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BEST7003_0116	COG0088	Forms part of the polypeptide exit tunnel
BEST7003_0117	COG0089	rRNA binding
BEST7003_0118	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BEST7003_0119	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BEST7003_0120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BEST7003_0121	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BEST7003_0122	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BEST7003_0123	COG0255	Belongs to the universal ribosomal protein uL29 family
BEST7003_0124	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BEST7003_0125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BEST7003_0127	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BEST7003_0129	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BEST7003_0130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BEST7003_0131	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BEST7003_0133	COG1841	ribosomal large subunit assembly
BEST7003_0134	COG0200	Binds to the 23S rRNA
BEST7003_0135	COG0201	protein transport
BEST7003_0136	COG0563	adenylate kinase activity
BEST7003_0137	COG0024	Methionine aminopeptidase
BEST7003_0138	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BEST7003_0139	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BEST7003_0140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BEST7003_0141	COG0202	RNA polymerase activity
BEST7003_0142	COG0203	ribosomal protein L17
BEST7003_0143	COG1122	ATPase activity
BEST7003_0144	COG1122	ATPase activity
BEST7003_0145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BEST7003_0146	COG0101	tRNA pseudouridine synthase activity
BEST7003_0147	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BEST7003_0148	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BEST7003_0149	COG2226	methyltransferase
BEST7003_0151	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_0152	COG0489	protein tyrosine kinase activity
BEST7003_0154	COG2194	sulfuric ester hydrolase activity
BEST7003_0155	COG0726	polysaccharide deacetylase
BEST7003_0156	COG0659	secondary active sulfate transmembrane transporter activity
BEST7003_0158	COG0385	Bile acid
BEST7003_0159	COG2819	hydrolase of the alpha beta superfamily
BEST7003_0160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_0161	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_0162	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_0163	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_0163	COG2207	Transcriptional regulator
BEST7003_0164	COG3876	Protein conserved in bacteria
BEST7003_0165	COG1472	Belongs to the glycosyl hydrolase 3 family
BEST7003_0166	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7003_0167	COG1263	PTS System
BEST7003_0167	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_0168	COG1737	Transcriptional regulator
BEST7003_0169	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BEST7003_0170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_0171	COG1683	Conserved Protein
BEST7003_0172	COG1595	DNA-templated transcription, initiation
BEST7003_0173	COG5662	AntiSigma factor
BEST7003_0174	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BEST7003_0175	COG4856	YbbR-like protein
BEST7003_0176	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BEST7003_0177	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BEST7003_0179	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BEST7003_0180	COG2169	Transcriptional regulator
BEST7003_0181	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BEST7003_0182	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7003_0183	COG3002	Belongs to the UPF0753 family
BEST7003_0184	COG0288	reversible hydration of carbon dioxide
BEST7003_0186	COG5609	conserved protein (DUF2294)
BEST7003_0188	COG0640	Transcriptional regulator
BEST7003_0189	COG2814	Major facilitator Superfamily
BEST7003_0190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BEST7003_0192	COG0535	radical SAM domain protein
BEST7003_0193	COG1266	CAAX protease self-immunity
BEST7003_0194	COG1131	(ABC) transporter
BEST7003_0196	COG1413	lyase activity
BEST7003_0197	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_0198	COG0596	Alpha beta hydrolase
BEST7003_0199	COG0745	RESPONSE REGULATOR receiver
BEST7003_0200	COG0642	Histidine kinase
BEST7003_0202	COG0515	serine threonine protein kinase
BEST7003_0205	COG1113	amino acid transport
BEST7003_0208	COG2602	Beta-lactamase
BEST7003_0209	COG2124	cytochrome p450
BEST7003_0211	COG0531	amino acid
BEST7003_0212	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7003_0213	COG2271	Major facilitator Superfamily
BEST7003_0215	COG0456	acetyltransferase
BEST7003_0215	COG1846	Transcriptional regulator
BEST7003_0216	COG2271	Major facilitator Superfamily
BEST7003_0219	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_0220	COG0697	spore germination
BEST7003_0221	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_0221	COG2207	Transcriptional regulator
BEST7003_0222	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BEST7003_0223	COG3591	Belongs to the peptidase S1B family
BEST7003_0225	COG0596	Alpha beta hydrolase
BEST7003_0226	COG1183	phosphatidylcholine synthase activity
BEST7003_0227	COG0586	Pfam SNARE associated Golgi protein
BEST7003_0228	COG0688	phosphatidylethanolamine metabolic process
BEST7003_0230	COG2312	Erythromycin esterase
BEST7003_0231	COG2207	Transcriptional regulator
BEST7003_0233	COG1301	dicarboxylic acid transport
BEST7003_0234	COG2190	(PTS) system
BEST7003_0234	COG1263	PTS System
BEST7003_0234	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_0235	COG0363	glucosamine-6-phosphate deaminase activity
BEST7003_0238	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_0239	COG0833	amino acid
BEST7003_0240	COG2040	homocysteine
BEST7003_0241	COG1115	amino acid carrier protein
BEST7003_0242	COG2066	Belongs to the glutaminase family
BEST7003_0243	COG4191	Histidine kinase
BEST7003_0244	COG0784	Response regulator, receiver
BEST7003_0245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BEST7003_0246	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_0247	COG2271	Major facilitator Superfamily
BEST7003_0248	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_0249	COG2186	Transcriptional regulator
BEST7003_0250	COG2721	sulfolactate sulfo-lyase activity
BEST7003_0251	COG3173	Aminoglycoside phosphotransferase
BEST7003_0253	COG0697	spore germination
BEST7003_0254	COG0745	RESPONSE REGULATOR receiver
BEST7003_0255	COG2205	protein histidine kinase activity
BEST7003_0256	COG1131	(ABC) transporter
BEST7003_0259	COG3773	Cell wall hydrolase
BEST7003_0260	COG2304	oxidoreductase activity
BEST7003_0261	COG3540	Alkaline phosphatase
BEST7003_0262	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7003_0263	COG0805	protein transport
BEST7003_0264	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BEST7003_0265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7003_0266	COG0477	Major facilitator Superfamily
BEST7003_0267	COG1309	transcriptional regulator
BEST7003_0268	COG0252	asparaginase activity
BEST7003_0269	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BEST7003_0270	COG1714	RDD family
BEST7003_0271	COG3012	SEC-C Motif Domain Protein
BEST7003_0271	COG1405	negative regulation of cell septum assembly
BEST7003_0272	COG3290	protein histidine kinase activity
BEST7003_0273	COG3279	Response regulator of the LytR AlgR family
BEST7003_0274	COG4555	ABC transporter
BEST7003_0275	COG1668	transmembrane transport
BEST7003_0276	COG0667	Aldo Keto reductase
BEST7003_0278	COG1595	DNA-templated transcription, initiation
BEST7003_0279	COG1595	DNA-templated transcription, initiation
BEST7003_0280	COG1876	peptidase activity
BEST7003_0281	COG0457	Tetratricopeptide repeat
BEST7003_0282	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_0283	COG0366	Alpha amylase catalytic
BEST7003_0284	COG0803	Belongs to the bacterial solute-binding protein 9 family
BEST7003_0285	COG1121	(ABC) transporter
BEST7003_0286	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7003_0287	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_0288	COG2310	stress, protein
BEST7003_0289	COG2310	stress, protein
BEST7003_0290	COG2310	stress, protein
BEST7003_0291	COG0861	Integral membrane protein TerC family
BEST7003_0293	COG3853	Toxic anion resistance protein (TelA)
BEST7003_0294	COG0477	Major facilitator Superfamily
BEST7003_0295	COG2814	Major facilitator Superfamily
BEST7003_0296	COG0640	Transcriptional regulator
BEST7003_0297	COG0517	IMP dehydrogenase activity
BEST7003_0297	COG4175	Glycine betaine
BEST7003_0298	COG4176	ABC-type proline glycine betaine transport system permease component
BEST7003_0299	COG2113	Glycine betaine
BEST7003_0300	COG1473	amidohydrolase
BEST7003_0301	COG1288	antiporter activity
BEST7003_0303	COG0366	Alpha amylase catalytic
BEST7003_0304	COG0039	L-malate dehydrogenase activity
BEST7003_0305	COG1620	l-lactate permease
BEST7003_0306	COG2814	Major facilitator Superfamily
BEST7003_0307	COG1846	Transcriptional regulator
BEST7003_0308	COG1280	lysine exporter protein (LysE YggA)
BEST7003_0309	COG3403	YqcI/YcgG family
BEST7003_0310	COG1113	amino acid transport
BEST7003_0311	COG3665	Urea carboxylase-associated protein
BEST7003_0312	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BEST7003_0313	COG1660	Displays ATPase and GTPase activities
BEST7003_0314	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BEST7003_0315	COG2226	methyltransferase
BEST7003_0316	COG0583	DNA-binding transcription factor activity
BEST7003_0317	COG3458	cephalosporin-C deacetylase activity
BEST7003_0318	COG3541	Predicted nucleotidyltransferase
BEST7003_0319	COG0506	proline dehydrogenase activity
BEST7003_0320	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_0321	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_0322	COG2508	Transcriptional regulator
BEST7003_0323	COG3689	TIGRFAM TIGR03943 family protein
BEST7003_0324	COG0701	Predicted permease
BEST7003_0325	COG2267	carboxylic ester hydrolase activity
BEST7003_0326	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_0327	COG1587	Uroporphyrinogen-III synthase
BEST7003_0327	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BEST7003_0328	COG2146	nitrite reductase [NAD(P)H] activity
BEST7003_0329	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7003_0330	COG0243	molybdopterin cofactor binding
BEST7003_0331	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7003_0332	COG2223	nitrite transmembrane transporter activity
BEST7003_0333	COG1469	GTP cyclohydrolase I activity
BEST7003_0334	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7003_0335	COG0523	cobalamin synthesis protein
BEST7003_0336	COG0765	amino acid transport
BEST7003_0337	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_0339	COG1714	RDD family
BEST7003_0341	COG2723	6-phospho-beta-galactosidase activity
BEST7003_0343	COG3209	COG3209 Rhs family protein
BEST7003_0344	COG3290	protein histidine kinase activity
BEST7003_0344	COG0840	transmembrane signaling receptor activity
BEST7003_0345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BEST7003_0346	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BEST7003_0347	COG1733	regulation of RNA biosynthetic process
BEST7003_0348	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_0349	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_0350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_0351	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BEST7003_0352	COG2814	Major facilitator Superfamily
BEST7003_0354	COG0697	spore germination
BEST7003_0355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_0358	COG2364	Membrane
BEST7003_0359	COG1126	abc transporter atp-binding protein
BEST7003_0360	COG0765	amino acid transport
BEST7003_0361	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_0362	COG0583	DNA-binding transcription factor activity
BEST7003_0363	COG0163	prenyltransferase activity
BEST7003_0364	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BEST7003_0367	COG0596	Alpha beta hydrolase
BEST7003_0368	COG3104	oligopeptide transport
BEST7003_0369	COG5434	Belongs to the glycosyl hydrolase 28 family
BEST7003_0371	COG0697	spore germination
BEST7003_0373	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BEST7003_0374	COG1136	(ABC) transporter
BEST7003_0375	COG0577	efflux transmembrane transporter activity
BEST7003_0376	COG0745	RESPONSE REGULATOR receiver
BEST7003_0377	COG5002	protein histidine kinase activity
BEST7003_0377	COG3850	Histidine kinase
BEST7003_0378	COG0457	Tetratricopeptide repeat
BEST7003_0380	COG0527	aspartate kinase activity
BEST7003_0381	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_0382	COG4605	iron ion homeostasis
BEST7003_0383	COG4604	ABC transporter, ATP-binding protein
BEST7003_0384	COG4607	ABC-type enterochelin transport system periplasmic component
BEST7003_0385	COG2814	Major facilitator Superfamily
BEST7003_0386	COG1309	transcriptional regulator
BEST7003_0387	COG0778	Nitroreductase
BEST7003_0388	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BEST7003_0389	COG0640	Transcriptional regulator
BEST7003_0390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_0391	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BEST7003_0392	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_0393	COG4975	Glucose uptake
BEST7003_0394	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_0395	COG4549	nuclear export factor GLE1
BEST7003_0396	COG1276	copper resistance
BEST7003_0396	COG2372	response to copper ion
BEST7003_0397	COG1349	DNA-binding transcription factor activity
BEST7003_0399	COG2213	PTS system mannitol-specific
BEST7003_0400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_0401	COG0246	Mannitol dehydrogenase
BEST7003_0402	COG0473	3-isopropylmalate dehydrogenase activity
BEST7003_0404	COG0681	Belongs to the peptidase S26 family
BEST7003_0405	COG0412	Dienelactone hydrolase
BEST7003_0406	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BEST7003_0408	COG0561	phosphatase activity
BEST7003_0409	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BEST7003_0410	COG1914	H( )-stimulated, divalent metal cation uptake system
BEST7003_0411	COG4336	lyase activity
BEST7003_0412	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BEST7003_0413	COG1984	allophanate hydrolase subunit 2
BEST7003_0414	COG1414	Transcriptional regulator
BEST7003_0415	COG2755	lipolytic protein G-D-S-L family
BEST7003_0417	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_0418	COG0768	penicillin binding
BEST7003_0419	COG4989	oxidoreductase activity
BEST7003_0420	COG3711	transcriptional antiterminator
BEST7003_0421	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_0422	COG2226	methyltransferase
BEST7003_0423	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_0424	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_0425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_0426	COG3871	stress protein (general stress protein 26)
BEST7003_0428	COG2814	Major facilitator Superfamily
BEST7003_0429	COG1522	sequence-specific DNA binding
BEST7003_0430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BEST7003_0430	COG0551	DNA topoisomerase type I activity
BEST7003_0431	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BEST7003_0432	COG3706	GGDEF domain
BEST7003_0433	COG5298	Protein conserved in bacteria
BEST7003_0434	COG1215	transferase activity, transferring glycosyl groups
BEST7003_0436	COG0531	amino acid
BEST7003_0437	COG0494	nUDIX hydrolase
BEST7003_0438	COG0028	Belongs to the TPP enzyme family
BEST7003_0441	COG1914	H( )-stimulated, divalent metal cation uptake system
BEST7003_0442	COG2261	transglycosylase associated protein
BEST7003_0443	COG4876	unkown
BEST7003_0444	COG2217	Heavy metal translocating P-type atpase
BEST7003_0445	COG3729	General stress protein
BEST7003_0446	COG0662	Cupin 2, conserved barrel domain protein
BEST7003_0447	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_0448	COG3546	catalase activity
BEST7003_0449	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BEST7003_0450	COG3290	protein histidine kinase activity
BEST7003_0451	COG4565	transcriptional regulatory protein
BEST7003_0452	COG1301	dicarboxylic acid transport
BEST7003_0453	COG0628	permease
BEST7003_0454	COG1131	(ABC) transporter
BEST7003_0455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7003_0457	COG1960	acyl-CoA dehydrogenase activity
BEST7003_0460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7003_0461	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_0462	COG1181	Belongs to the D-alanine--D-alanine ligase family
BEST7003_0463	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BEST7003_0464	COG0513	Belongs to the DEAD box helicase family
BEST7003_0465	COG3402	PFAM membrane-flanked domain
BEST7003_0466	COG3428	Bacterial PH domain
BEST7003_0467	COG0705	Rhomboid family
BEST7003_0468	COG0736	holo-[acyl-carrier-protein] synthase activity
BEST7003_0469	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BEST7003_0470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BEST7003_0471	COG0864	Transcriptional regulator
BEST7003_0472	COG2337	Toxic component of a toxin-antitoxin (TA) module
BEST7003_0473	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_0474	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_0475	COG2172	sigma factor antagonist activity
BEST7003_0476	COG2208	phosphoserine phosphatase activity
BEST7003_0477	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_0478	COG2172	sigma factor antagonist activity
BEST7003_0479	COG1191	sigma factor activity
BEST7003_0480	COG2208	phosphoserine phosphatase activity
BEST7003_0483	COG1673	EVE domain
BEST7003_0484	COG1846	Transcriptional regulator
BEST7003_0485	COG2183	response to ionizing radiation
BEST7003_0486	COG3091	SprT-like family
BEST7003_0487	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_0488	COG1522	sequence-specific DNA binding
BEST7003_0489	COG1522	sequence-specific DNA binding
BEST7003_0490	COG1335	isochorismatase
BEST7003_0491	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BEST7003_0492	COG2814	Major facilitator Superfamily
BEST7003_0496	COG0693	protein deglycase activity
BEST7003_0497	COG1278	Cold shock
BEST7003_0498	COG1329	Transcriptional regulator
BEST7003_0499	COG0697	spore germination
BEST7003_0500	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_0500	COG2207	Transcriptional regulator
BEST7003_0501	COG0697	spore germination
BEST7003_0502	COG2207	Transcriptional regulator
BEST7003_0502	COG3708	Transcriptional regulator
BEST7003_0503	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_0504	COG0477	Major facilitator Superfamily
BEST7003_0506	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BEST7003_0508	COG0697	spore germination
BEST7003_0509	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_0510	COG2030	dehydratase
BEST7003_0511	COG3545	Serine hydrolase
BEST7003_0512	COG1733	regulation of RNA biosynthetic process
BEST7003_0513	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_0514	COG1733	regulation of RNA biosynthetic process
BEST7003_0515	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7003_0516	COG2814	Major facilitator Superfamily
BEST7003_0517	COG1309	transcriptional regulator
BEST7003_0519	COG0640	Transcriptional regulator
BEST7003_0520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BEST7003_0521	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_0522	COG0697	spore germination
BEST7003_0523	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_0524	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7003_0525	COG0640	Transcriptional regulator
BEST7003_0526	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BEST7003_0528	COG4585	Histidine kinase
BEST7003_0529	COG2197	response regulator
BEST7003_0530	COG2409	Drug exporters of the RND superfamily
BEST7003_0531	COG0596	Alpha beta hydrolase
BEST7003_0532	COG1811	Na channel or pump
BEST7003_0533	COG0789	Transcriptional regulator
BEST7003_0533	COG4978	Transcriptional regulator
BEST7003_0534	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7003_0535	COG0778	Nitroreductase
BEST7003_0536	COG0346	lactoylglutathione lyase activity
BEST7003_0537	COG2259	Doxx family
BEST7003_0538	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_0541	COG2323	membrane
BEST7003_0542	COG2323	membrane
BEST7003_0543	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_0546	COG1309	transcriptional regulator
BEST7003_0548	COG0456	acetyltransferase
BEST7003_0550	COG1113	amino acid transport
BEST7003_0551	COG2318	DinB family
BEST7003_0552	COG1846	Transcriptional regulator
BEST7003_0553	COG1033	growth of symbiont in host cell
BEST7003_0553	COG2409	Drug exporters of the RND superfamily
BEST7003_0554	COG0778	Nitroreductase
BEST7003_0555	COG1846	Transcriptional regulator
BEST7003_0556	COG2814	Major facilitator Superfamily
BEST7003_0557	COG0730	response to heat
BEST7003_0558	COG1802	Transcriptional regulator
BEST7003_0559	COG1388	LysM domain
BEST7003_0559	COG3858	chitin binding
BEST7003_0560	COG1819	glycosyl
BEST7003_0562	COG1785	Belongs to the alkaline phosphatase family
BEST7003_0563	COG5646	InterPro IPR014922
BEST7003_0565	COG0454	-acetyltransferase
BEST7003_0566	COG1078	dGTPase activity
BEST7003_0567	COG1388	LysM domain
BEST7003_0568	COG2814	Major facilitator Superfamily
BEST7003_0569	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_0570	COG1447	Phosphotransferase system cellobiose-specific component IIA
BEST7003_0571	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_0572	COG2723	6-phospho-beta-galactosidase activity
BEST7003_0573	COG2188	Transcriptional regulator
BEST7003_0574	COG1940	carbohydrate kinase activity
BEST7003_0575	COG1482	cell wall glycoprotein biosynthetic process
BEST7003_0576	COG4124	Belongs to the glycosyl hydrolase 26 family
BEST7003_0580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BEST7003_0581	COG0802	atpase or kinase
BEST7003_0582	COG1214	PFAM Peptidase M22, glycoprotease
BEST7003_0583	COG0456	acetyltransferase
BEST7003_0584	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BEST7003_0585	COG0488	(ABC) transporter
BEST7003_0586	COG0315	cyclic pyranopterin monophosphate synthase activity
BEST7003_0587	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BEST7003_0588	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7003_0589	COG0805	protein transport
BEST7003_0591	COG1266	CAAX protease self-immunity
BEST7003_0592	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BEST7003_0595	COG0457	Tetratricopeptide repeat
BEST7003_0596	COG1063	alcohol dehydrogenase
BEST7003_0597	COG2211	Major facilitator Superfamily
BEST7003_0598	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_0600	COG1842	Phage shock protein A
BEST7003_0601	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BEST7003_0602	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BEST7003_0603	COG4260	virion core protein, lumpy skin disease virus
BEST7003_0604	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BEST7003_0604	COG2755	lipolytic protein G-D-S-L family
BEST7003_0606	COG1595	DNA-templated transcription, initiation
BEST7003_0607	COG1063	alcohol dehydrogenase
BEST7003_0608	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BEST7003_0609	COG0823	Involved in the tonB-independent uptake of proteins
BEST7003_0612	COG2132	Multicopper oxidase
BEST7003_0613	COG1113	amino acid transport
BEST7003_0614	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7003_0615	COG0714	Associated with various cellular activities
BEST7003_0616	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BEST7003_0617	COG1305	Transglutaminase-like
BEST7003_0619	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7003_0623	COG2211	Major facilitator Superfamily
BEST7003_0626	COG2252	PERMEase
BEST7003_0627	COG3064	Membrane
BEST7003_0631	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BEST7003_0632	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BEST7003_0633	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BEST7003_0634	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BEST7003_0635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BEST7003_0638	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BEST7003_0639	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BEST7003_0640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BEST7003_0641	COG0138	bifunctional purine biosynthesis protein purh
BEST7003_0642	COG0151	Belongs to the GarS family
BEST7003_0643	COG1522	sequence-specific DNA binding
BEST7003_0644	COG0531	amino acid
BEST7003_0646	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BEST7003_0647	COG1470	cell adhesion involved in biofilm formation
BEST7003_0648	COG4496	protein, YerC YecD
BEST7003_0649	COG0069	glutamate synthase activity
BEST7003_0650	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BEST7003_0651	COG0210	DNA helicase
BEST7003_0652	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BEST7003_0653	COG4851	CamS sex pheromone cAM373 precursor
BEST7003_0654	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_0655	COG1285	pathogenesis
BEST7003_0656	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_0657	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7003_0658	COG0154	amidase activity
BEST7003_0659	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7003_0660	COG1309	transcriptional regulator
BEST7003_0661	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BEST7003_0662	COG1597	lipid kinase activity
BEST7003_0663	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BEST7003_0664	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_0665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_0666	COG1002	Type II restriction enzyme, methylase subunits
BEST7003_0667	COG1061	Type III restriction enzyme res subunit
BEST7003_0668	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7003_0672	COG5444	nuclease activity
BEST7003_0673	COG3391	amine dehydrogenase activity
BEST7003_0674	COG0457	Tetratricopeptide repeat
BEST7003_0676	COG0217	transcriptional regulatory protein
BEST7003_0678	COG1309	transcriptional regulator
BEST7003_0679	COG3631	Ketosteroid isomerase-related protein
BEST7003_0680	COG0702	epimerase
BEST7003_0683	COG3546	catalase activity
BEST7003_0684	COG0454	-acetyltransferase
BEST7003_0686	COG5578	integral membrane protein
BEST7003_0687	COG2972	Histidine kinase
BEST7003_0688	COG4753	response regulator
BEST7003_0688	COG2207	Transcriptional regulator
BEST7003_0689	COG1653	transport
BEST7003_0690	COG1175	transmembrane transport
BEST7003_0691	COG0395	ABC-type sugar transport system, permease component
BEST7003_0692	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BEST7003_0693	COG2207	Transcriptional regulator
BEST7003_0694	COG2755	lipolytic protein G-D-S-L family
BEST7003_0696	COG5578	integral membrane protein
BEST7003_0697	COG3401	FG-GAP repeat protein
BEST7003_0698	COG3401	FG-GAP repeat protein
BEST7003_0699	COG2755	lipolytic protein G-D-S-L family
BEST7003_0700	COG1874	Beta-galactosidase
BEST7003_0702	COG1653	transport
BEST7003_0703	COG4209	transmembrane transport
BEST7003_0704	COG0395	ABC-type sugar transport system, permease component
BEST7003_0705	COG1486	melibiose metabolic process
BEST7003_0706	COG2323	membrane
BEST7003_0707	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_0708	COG0346	lactoylglutathione lyase activity
BEST7003_0710	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_0712	COG5583	Uncharacterized small protein (DUF2292)
BEST7003_0713	COG0670	Belongs to the BI1 family
BEST7003_0714	COG0697	spore germination
BEST7003_0715	COG1846	Transcriptional regulator
BEST7003_0716	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7003_0718	COG2124	cytochrome p450
BEST7003_0718	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7003_0719	COG1368	sulfuric ester hydrolase activity
BEST7003_0720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BEST7003_0721	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_0722	COG1442	glycosyl transferase family 8
BEST7003_0723	COG1216	Glycosyl transferase, family 2
BEST7003_0724	COG1442	glycosyl transferase family 8
BEST7003_0725	COG2223	nitrite transmembrane transporter activity
BEST7003_0726	COG1011	Hydrolase
BEST7003_0727	COG0531	amino acid
BEST7003_0728	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_0729	COG0840	transmembrane signaling receptor activity
BEST7003_0730	COG0488	(ABC) transporter
BEST7003_0732	COG0789	Transcriptional regulator
BEST7003_0733	COG2814	Major facilitator Superfamily
BEST7003_0735	COG0488	(ABC) transporter
BEST7003_0736	COG0513	Belongs to the DEAD box helicase family
BEST7003_0737	COG0456	acetyltransferase
BEST7003_0738	COG2130	NADP-dependent
BEST7003_0740	COG2211	Major facilitator Superfamily
BEST7003_0741	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BEST7003_0742	COG1120	ATPase activity
BEST7003_0743	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_0744	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_0745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BEST7003_0748	COG3866	Pectate lyase
BEST7003_0749	COG0471	metal ion transport
BEST7003_0750	COG3290	protein histidine kinase activity
BEST7003_0751	COG4565	transcriptional regulatory protein
BEST7003_0752	COG3181	Tripartite tricarboxylate transporter family receptor
BEST7003_0753	COG2851	Citrate transporter
BEST7003_0754	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_0755	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BEST7003_0756	COG1254	Belongs to the acylphosphatase family
BEST7003_0757	COG2258	MOSC domain
BEST7003_0761	COG0024	Methionine aminopeptidase
BEST7003_0762	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_0762	COG1263	PTS System
BEST7003_0763	COG1368	sulfuric ester hydrolase activity
BEST7003_0765	COG1115	amino acid carrier protein
BEST7003_0766	COG0531	amino acid
BEST7003_0769	COG0697	spore germination
BEST7003_0770	COG1263	PTS System
BEST7003_0770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_0771	COG0366	Alpha amylase catalytic
BEST7003_0772	COG2188	Transcriptional regulator
BEST7003_0773	COG0778	Nitroreductase
BEST7003_0774	COG0737	Belongs to the 5'-nucleotidase family
BEST7003_0775	COG0693	protein deglycase activity
BEST7003_0776	COG2814	Major facilitator Superfamily
BEST7003_0777	COG4840	Belongs to the UPF0435 family
BEST7003_0778	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7003_0779	COG4980	gas vesicle protein
BEST7003_0780	COG1295	ribonuclease BN
BEST7003_0781	COG0477	Major facilitator Superfamily
BEST7003_0782	COG0387	Pfam Sodium calcium exchanger
BEST7003_0784	COG0668	transmembrane transport
BEST7003_0785	COG0535	radical SAM domain protein
BEST7003_0787	COG0726	polysaccharide deacetylase
BEST7003_0788	COG2084	Dehydrogenase
BEST7003_0789	COG0598	Magnesium transport protein CorA
BEST7003_0790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BEST7003_0791	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BEST7003_0793	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7003_0794	COG4637	Psort location Cytoplasmic, score
BEST7003_0796	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7003_0797	COG0022	dehydrogenase e1 component
BEST7003_0798	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_0799	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7003_0800	COG3284	Transcriptional regulator
BEST7003_0802	COG1742	UPF0060 membrane protein
BEST7003_0807	COG4842	Belongs to the WXG100 family
BEST7003_0808	COG1486	melibiose metabolic process
BEST7003_0809	COG1737	Transcriptional regulator
BEST7003_0810	COG1263	PTS System
BEST7003_0810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_0811	COG1132	(ABC) transporter
BEST7003_0812	COG1132	(ABC) transporter
BEST7003_0813	COG2259	Doxx family
BEST7003_0814	COG2514	catechol 2,3-dioxygenase activity
BEST7003_0815	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_0815	COG4977	sequence-specific DNA binding
BEST7003_0816	COG2814	Major facilitator Superfamily
BEST7003_0817	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_0818	COG0673	inositol 2-dehydrogenase activity
BEST7003_0819	COG4585	Histidine kinase
BEST7003_0820	COG2197	response regulator
BEST7003_0821	COG1131	(ABC) transporter
BEST7003_0822	COG0842	Transport permease protein
BEST7003_0822	COG1511	domain protein
BEST7003_0823	COG0842	Transport permease protein
BEST7003_0824	COG1695	Transcriptional regulator
BEST7003_0825	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BEST7003_0826	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BEST7003_0827	COG1309	transcriptional regulator
BEST7003_0828	COG2814	Major facilitator Superfamily
BEST7003_0829	COG2318	DinB family
BEST7003_0830	COG2814	Major facilitator Superfamily
BEST7003_0831	COG1846	Transcriptional regulator
BEST7003_0832	COG0392	lysyltransferase activity
BEST7003_0832	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BEST7003_0833	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_0835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_0836	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_0837	COG0384	phenazine biosynthesis protein PhzF
BEST7003_0838	COG0778	Nitroreductase
BEST7003_0840	COG1090	epimerase
BEST7003_0841	COG2137	regulation of response to DNA damage stimulus
BEST7003_0843	COG2814	Major facilitator Superfamily
BEST7003_0846	COG3103	Sh3 type 3 domain protein
BEST7003_0847	COG5658	integral membrane protein
BEST7003_0848	COG0596	Alpha beta hydrolase
BEST7003_0849	COG0463	Glycosyl transferase, family 2
BEST7003_0850	COG4485	Bacterial membrane protein, YfhO
BEST7003_0851	COG1988	membrane-bound metal-dependent
BEST7003_0852	COG1194	a g-specific adenine glycosylase
BEST7003_0854	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_0857	COG3557	Belongs to the UPF0374 family
BEST7003_0858	COG1132	(ABC) transporter
BEST7003_0859	COG4129	membrane
BEST7003_0860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BEST7003_0861	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BEST7003_0862	COG0735	belongs to the Fur family
BEST7003_0865	COG4326	sporulation control protein
BEST7003_0867	COG3340	Belongs to the peptidase S51 family
BEST7003_0868	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BEST7003_0869	COG0277	FAD linked oxidase domain protein
BEST7003_0871	COG0753	catalase activity
BEST7003_0872	COG1116	anion transmembrane transporter activity
BEST7003_0873	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7003_0874	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7003_0875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_0877	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BEST7003_0879	COG1476	TRANSCRIPTIONal
BEST7003_0880	COG3382	B3 4 domain protein
BEST7003_0881	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BEST7003_0883	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BEST7003_0884	COG0789	Transcriptional regulator
BEST7003_0885	COG1664	Polymer-forming cytoskeletal
BEST7003_0886	COG1664	Polymer-forming cytoskeletal
BEST7003_0887	COG2766	serine protein kinase
BEST7003_0888	COG2718	Belongs to the UPF0229 family
BEST7003_0889	COG1846	Transcriptional regulator
BEST7003_0890	COG1566	PFAM secretion protein HlyD family protein
BEST7003_0891	COG2814	Major facilitator Superfamily
BEST7003_0892	COG0655	NAD(P)H dehydrogenase (quinone) activity
BEST7003_0895	COG1725	Transcriptional regulator
BEST7003_0896	COG1131	(ABC) transporter
BEST7003_0897	COG1131	(ABC) transporter
BEST7003_0898	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7003_0899	COG1278	Cold shock
BEST7003_0900	COG1464	Belongs to the NlpA lipoprotein family
BEST7003_0901	COG3706	GGDEF domain
BEST7003_0902	COG1823	symporter activity
BEST7003_0906	COG5577	PFAM Coat F domain
BEST7003_0907	COG1525	nuclease
BEST7003_0907	COG4085	toxin activity
BEST7003_0907	COG0737	Belongs to the 5'-nucleotidase family
BEST7003_0908	COG3764	Sortase (surface protein transpeptidase)
BEST7003_0909	COG0564	pseudouridine synthase activity
BEST7003_0911	COG0517	IMP dehydrogenase activity
BEST7003_0912	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BEST7003_0913	COG3153	acetyltransferase
BEST7003_0913	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7003_0915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7003_0916	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BEST7003_0917	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BEST7003_0918	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BEST7003_0919	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BEST7003_0920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BEST7003_0921	COG2203	Gaf domain
BEST7003_0921	COG4585	Histidine kinase
BEST7003_0922	COG2197	response regulator
BEST7003_0923	COG0431	NADPH-dependent FMN reductase
BEST7003_0926	COG1388	LysM domain
BEST7003_0926	COG0791	NLP P60 protein
BEST7003_0927	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_0928	COG0668	transmembrane transport
BEST7003_0929	COG2719	SpoVR family
BEST7003_0930	COG1785	Belongs to the alkaline phosphatase family
BEST7003_0931	COG1388	LysM domain
BEST7003_0931	COG0791	NLP P60 protein
BEST7003_0932	COG0583	DNA-binding transcription factor activity
BEST7003_0933	COG0372	Belongs to the citrate synthase family
BEST7003_0934	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_0935	COG0531	amino acid
BEST7003_0936	COG0733	neurotransmitter:sodium symporter activity
BEST7003_0937	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_0938	COG0456	acetyltransferase
BEST7003_0941	COG1595	DNA-templated transcription, initiation
BEST7003_0942	COG0667	Aldo Keto reductase
BEST7003_0943	COG0204	Acyl-transferase
BEST7003_0944	COG1253	flavin adenine dinucleotide binding
BEST7003_0945	COG0789	Transcriptional regulator
BEST7003_0946	COG0436	Aminotransferase
BEST7003_0947	COG1253	flavin adenine dinucleotide binding
BEST7003_0948	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BEST7003_0949	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BEST7003_0950	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7003_0952	COG0668	transmembrane transport
BEST7003_0953	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BEST7003_0954	COG0726	polysaccharide deacetylase
BEST7003_0955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_0956	COG1757	Na H antiporter
BEST7003_0957	COG0589	response to stress
BEST7003_0958	COG1132	(ABC) transporter
BEST7003_0959	COG1132	(ABC) transporter
BEST7003_0960	COG0702	epimerase
BEST7003_0963	COG0189	ligase activity
BEST7003_0964	COG0189	ligase activity
BEST7003_0965	COG4399	Belongs to the UPF0754 family
BEST7003_0966	COG3679	Belongs to the UPF0342 family
BEST7003_0967	COG4335	DNA alkylation repair
BEST7003_0968	COG0561	phosphatase activity
BEST7003_0969	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7003_0970	COG0475	glutathione-regulated potassium exporter activity
BEST7003_0971	COG0490	domain, Protein
BEST7003_0973	COG1024	Enoyl-CoA hydratase
BEST7003_0975	COG4152	abc transporter atp-binding protein
BEST7003_0976	COG1668	transmembrane transport
BEST7003_0977	COG0420	3'-5' exonuclease activity
BEST7003_0978	COG4717	serine-type aminopeptidase activity
BEST7003_0979	COG3481	metal-dependent phosphohydrolase, HD sub domain
BEST7003_0981	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BEST7003_0984	COG1846	Transcriptional regulator
BEST7003_0985	COG4980	gas vesicle protein
BEST7003_0987	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BEST7003_0988	COG0537	adenosine 5'-monophosphoramidase activity
BEST7003_0989	COG1131	(ABC) transporter
BEST7003_0990	COG4473	ABC transporter
BEST7003_0992	COG1473	amidohydrolase
BEST7003_0993	COG3069	C4-dicarboxylate transmembrane transporter activity
BEST7003_0994	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_0995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_0996	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BEST7003_0999	COG1309	transcriptional regulator
BEST7003_1000	COG1511	domain protein
BEST7003_1001	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7003_1002	COG4377	Putative membrane peptidase family (DUF2324)
BEST7003_1004	COG1363	Peptidase, m42
BEST7003_1005	COG4405	Protein conserved in bacteria
BEST7003_1006	COG1301	dicarboxylic acid transport
BEST7003_1007	COG1234	tRNA 3'-trailer cleavage
BEST7003_1008	COG0095	Lipoate-protein ligase
BEST7003_1009	COG0702	epimerase
BEST7003_1010	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_1012	COG0501	Belongs to the peptidase M48B family
BEST7003_1013	COG1404	Belongs to the peptidase S8 family
BEST7003_1014	COG0456	acetyltransferase
BEST7003_1015	COG0604	alcohol dehydrogenase
BEST7003_1016	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BEST7003_1017	COG0406	alpha-ribazole phosphatase activity
BEST7003_1018	COG0183	Belongs to the thiolase family
BEST7003_1019	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_1020	COG1268	BioY protein
BEST7003_1021	COG0840	transmembrane signaling receptor activity
BEST7003_1022	COG0723	plastoquinol--plastocyanin reductase activity
BEST7003_1022	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7003_1023	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1025	COG4903	ComK protein
BEST7003_1026	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1028	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_1031	COG0398	Pfam SNARE associated Golgi protein
BEST7003_1032	COG0681	Belongs to the peptidase S26 family
BEST7003_1033	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7003_1034	COG1846	Transcriptional regulator
BEST7003_1035	COG0738	Major facilitator superfamily
BEST7003_1037	COG0673	inositol 2-dehydrogenase activity
BEST7003_1038	COG0561	phosphatase activity
BEST7003_1039	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7003_1040	COG1609	Transcriptional regulator
BEST7003_1041	COG3180	Ammonia monooxygenase
BEST7003_1042	COG2814	Major facilitator Superfamily
BEST7003_1042	COG0477	Major facilitator Superfamily
BEST7003_1043	COG4533	DNA binding
BEST7003_1045	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BEST7003_1046	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BEST7003_1047	COG1074	ATP-dependent DNA helicase activity
BEST7003_1048	COG0420	3'-5' exonuclease activity
BEST7003_1049	COG0419	ATPase involved in DNA repair
BEST7003_1050	COG1403	HNH endonuclease
BEST7003_1058	COG0179	Fumarylacetoacetate (FAA) hydrolase
BEST7003_1060	COG1404	Belongs to the peptidase S8 family
BEST7003_1062	COG0367	asparagine synthase
BEST7003_1063	COG2318	DinB family
BEST7003_1064	COG1562	ergosterol biosynthetic process
BEST7003_1065	COG0534	Mate efflux family protein
BEST7003_1066	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_1066	COG2207	Transcriptional regulator
BEST7003_1067	COG1609	Transcriptional regulator
BEST7003_1068	COG0673	inositol 2-dehydrogenase activity
BEST7003_1069	COG2318	DinB family
BEST7003_1070	COG1279	arginine transmembrane transporter activity
BEST7003_1071	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7003_1072	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7003_1073	COG2267	carboxylic ester hydrolase activity
BEST7003_1074	COG0529	Catalyzes the synthesis of activated sulfate
BEST7003_1075	COG2046	Belongs to the sulfate adenylyltransferase family
BEST7003_1076	COG0175	sulfate reduction
BEST7003_1077	COG2045	Belongs to the ComB family
BEST7003_1078	COG1809	phosphosulfolactate synthase activity
BEST7003_1079	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_1080	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_1081	COG2814	Major facilitator Superfamily
BEST7003_1082	COG0454	-acetyltransferase
BEST7003_1083	COG2153	protein acetylation
BEST7003_1084	COG0646	methionine synthase
BEST7003_1084	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BEST7003_1085	COG1666	GTP binding
BEST7003_1086	COG2996	Protein conserved in bacteria
BEST7003_1091	COG1695	Transcriptional regulator
BEST7003_1094	COG3227	Zinc metalloprotease (Elastase)
BEST7003_1095	COG1307	EDD domain protein, DegV family
BEST7003_1096	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_1099	COG0561	phosphatase activity
BEST7003_1100	COG1073	alpha beta
BEST7003_1101	COG2151	metal-sulfur cluster biosynthetic enzyme
BEST7003_1103	COG0277	FAD linked oxidase domain protein
BEST7003_1104	COG2271	Major facilitator Superfamily
BEST7003_1105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BEST7003_1108	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BEST7003_1109	COG0505	Belongs to the CarA family
BEST7003_1110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7003_1111	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BEST7003_1114	COG2267	carboxylic ester hydrolase activity
BEST7003_1116	COG1744	ABC transporter substrate-binding protein PnrA-like
BEST7003_1119	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7003_1120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7003_1121	COG5504	Zn-dependent protease
BEST7003_1122	COG0444	Belongs to the ABC transporter superfamily
BEST7003_1123	COG4608	Belongs to the ABC transporter superfamily
BEST7003_1126	COG0601	transmembrane transport
BEST7003_1127	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7003_1129	COG0180	Tryptophanyl-tRNA synthetase
BEST7003_1130	COG4166	transmembrane transport
BEST7003_1131	COG0601	transmembrane transport
BEST7003_1132	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7003_1133	COG0444	Belongs to the ABC transporter superfamily
BEST7003_1134	COG4608	Belongs to the ABC transporter superfamily
BEST7003_1135	COG2814	Major facilitator Superfamily
BEST7003_1136	COG0456	acetyltransferase
BEST7003_1137	COG1393	Belongs to the ArsC family
BEST7003_1138	COG0861	Integral membrane protein TerC family
BEST7003_1139	COG4862	establishment of competence for transformation
BEST7003_1140	COG4469	Competence protein
BEST7003_1141	COG1164	Oligoendopeptidase f
BEST7003_1144	COG2346	COG2346, Truncated hemoglobins
BEST7003_1145	COG0741	lytic transglycosylase activity
BEST7003_1146	COG4116	CYTH
BEST7003_1148	COG2357	RelA SpoT domain protein
BEST7003_1149	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7003_1150	COG0564	pseudouridine synthase activity
BEST7003_1151	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BEST7003_1152	COG0475	glutathione-regulated potassium exporter activity
BEST7003_1152	COG0569	domain protein
BEST7003_1153	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BEST7003_1154	COG0352	thiamine-phosphate diphosphorylase activity
BEST7003_1155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7003_1156	COG2104	thiamine diphosphate biosynthetic process
BEST7003_1157	COG2022	thiamine diphosphate biosynthetic process
BEST7003_1158	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BEST7003_1159	COG0351	phosphomethylpyrimidine kinase
BEST7003_1160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BEST7003_1171	COG0210	DNA helicase
BEST7003_1173	COG2153	protein acetylation
BEST7003_1174	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BEST7003_1175	COG2382	esterase
BEST7003_1176	COG0626	cystathionine gamma-synthase activity
BEST7003_1177	COG0626	cystathionine gamma-synthase activity
BEST7003_1178	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_1179	COG5505	Protein of unknown function (DUF819)
BEST7003_1185	COG3677	Transposase
BEST7003_1188	COG5484	DNA packaging
BEST7003_1189	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BEST7003_1190	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1192	COG3711	transcriptional antiterminator
BEST7003_1192	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_1193	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_1193	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_1193	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_1194	COG1482	cell wall glycoprotein biosynthetic process
BEST7003_1196	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_1198	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BEST7003_1202	COG0109	protoheme IX farnesyltransferase activity
BEST7003_1204	COG0726	polysaccharide deacetylase
BEST7003_1207	COG5504	Zn-dependent protease
BEST7003_1208	COG2205	protein histidine kinase activity
BEST7003_1210	COG3383	formate dehydrogenase (NAD+) activity
BEST7003_1211	COG2427	Protein of unknown function (DUF1641)
BEST7003_1213	COG1051	belongs to the nudix hydrolase family
BEST7003_1215	COG2124	cytochrome p450
BEST7003_1216	COG1819	glycosyl
BEST7003_1218	COG1587	Uroporphyrinogen-III synthase
BEST7003_1219	COG0390	transport system, permease component
BEST7003_1220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7003_1221	COG0697	spore germination
BEST7003_1222	COG4297	protein containing double-stranded beta helix domain
BEST7003_1224	COG1252	NADH dehydrogenase
BEST7003_1225	COG1904	glucuronate isomerase
BEST7003_1226	COG2211	Major facilitator Superfamily
BEST7003_1227	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BEST7003_1228	COG1063	alcohol dehydrogenase
BEST7003_1229	COG1312	Catalyzes the dehydration of D-mannonate
BEST7003_1230	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1231	COG2271	Major facilitator Superfamily
BEST7003_1232	COG1609	Transcriptional regulator
BEST7003_1233	COG0246	Mannitol dehydrogenase
BEST7003_1234	COG2721	sulfolactate sulfo-lyase activity
BEST7003_1235	COG0730	response to heat
BEST7003_1236	COG2318	DinB family
BEST7003_1237	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7003_1238	COG0457	Tetratricopeptide repeat
BEST7003_1240	COG2350	Protein conserved in bacteria
BEST7003_1241	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_1241	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_1241	COG1388	LysM domain
BEST7003_1243	COG4195	phage-related replication protein
BEST7003_1244	COG3546	catalase activity
BEST7003_1245	COG2856	Zn peptidase
BEST7003_1246	COG1396	sequence-specific DNA binding
BEST7003_1248	COG1522	sequence-specific DNA binding
BEST7003_1249	COG1484	DNA-dependent DNA replication
BEST7003_1253	COG1595	DNA-templated transcription, initiation
BEST7003_1254	COG5484	DNA packaging
BEST7003_1254	COG3728	DNA packaging
BEST7003_1255	COG1783	phage Terminase large subunit
BEST7003_1256	COG5518	Phage portal protein
BEST7003_1257	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BEST7003_1258	COG4653	Phage capsid family
BEST7003_1268	COG3953	SLT domain
BEST7003_1268	COG5412	phage tail tape measure protein
BEST7003_1269	COG1652	LysM domain
BEST7003_1270	COG4193	domain, Protein
BEST7003_1272	COG3628	GPW Gp25 family protein
BEST7003_1273	COG3299	homolog of phage Mu protein gp47
BEST7003_1274	COG3778	Protein conserved in bacteria
BEST7003_1282	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_1282	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_1285	COG0306	phosphate transporter
BEST7003_1286	COG1392	Phosphate transport regulator
BEST7003_1287	COG0531	amino acid
BEST7003_1288	COG0346	lactoylglutathione lyase activity
BEST7003_1290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BEST7003_1291	COG0463	Glycosyl transferase, family 2
BEST7003_1293	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_1294	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_1295	COG2362	D-Aminopeptidase
BEST7003_1296	COG0601	transmembrane transport
BEST7003_1297	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7003_1298	COG0444	Belongs to the ABC transporter superfamily
BEST7003_1299	COG4166	transmembrane transport
BEST7003_1300	COG1619	proteins homologs of microcin C7 resistance protein MccF
BEST7003_1301	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_1302	COG0791	NLP P60 protein
BEST7003_1303	COG4608	Belongs to the ABC transporter superfamily
BEST7003_1304	COG2706	6-phosphogluconolactonase activity
BEST7003_1305	COG1834	amidinotransferase
BEST7003_1306	COG1607	acyl-coa hydrolase
BEST7003_1307	COG1017	nitric oxide dioxygenase activity
BEST7003_1307	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BEST7003_1309	COG2323	membrane
BEST7003_1310	COG2318	DinB family
BEST7003_1311	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_1312	COG2076	Multidrug Resistance protein
BEST7003_1313	COG2076	Multidrug Resistance protein
BEST7003_1314	COG0788	formyltetrahydrofolate deformylase activity
BEST7003_1315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7003_1322	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7003_1323	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BEST7003_1324	COG1764	response to oxidative stress
BEST7003_1325	COG1846	Transcriptional regulator
BEST7003_1326	COG1764	response to oxidative stress
BEST7003_1328	COG0590	tRNA wobble adenosine to inosine editing
BEST7003_1329	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7003_1330	COG1404	Belongs to the peptidase S8 family
BEST7003_1331	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_1332	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BEST7003_1333	COG1122	ATPase activity
BEST7003_1334	COG4721	ABC-type cobalt transport system, permease component
BEST7003_1336	COG0745	RESPONSE REGULATOR receiver
BEST7003_1337	COG3850	Histidine kinase
BEST7003_1337	COG5002	protein histidine kinase activity
BEST7003_1338	COG3212	peptidase
BEST7003_1339	COG3212	peptidase
BEST7003_1342	COG2239	Acts as a magnesium transporter
BEST7003_1343	COG0789	Transcriptional regulator
BEST7003_1346	COG1846	Transcriptional regulator
BEST7003_1347	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7003_1348	COG0726	polysaccharide deacetylase
BEST7003_1349	COG1408	metallophosphoesterase
BEST7003_1351	COG0463	Glycosyl transferase, family 2
BEST7003_1352	COG1793	dna ligase
BEST7003_1352	COG3285	dna ligase
BEST7003_1353	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BEST7003_1354	COG5001	Diguanylate cyclase
BEST7003_1354	COG3300	MHYT domain
BEST7003_1355	COG0586	Pfam SNARE associated Golgi protein
BEST7003_1356	COG0861	Integral membrane protein TerC family
BEST7003_1357	COG1191	sigma factor activity
BEST7003_1361	COG0501	Belongs to the peptidase M48B family
BEST7003_1362	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BEST7003_1365	COG3594	Acyltransferase
BEST7003_1366	COG5002	protein histidine kinase activity
BEST7003_1367	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BEST7003_1369	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BEST7003_1370	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BEST7003_1371	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7003_1372	COG0436	Aminotransferase
BEST7003_1373	COG1850	ribulose-bisphosphate carboxylase activity
BEST7003_1374	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BEST7003_1375	COG0235	Class ii aldolase
BEST7003_1376	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BEST7003_1377	COG3339	Conserved Protein
BEST7003_1380	COG3852	Histidine kinase
BEST7003_1381	COG1846	Transcriptional regulator
BEST7003_1382	COG1360	Flagellar Motor Protein
BEST7003_1383	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BEST7003_1384	COG0542	response to heat
BEST7003_1385	COG3949	Membrane
BEST7003_1386	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BEST7003_1387	COG0720	synthase
BEST7003_1388	COG0602	queuosine metabolic process
BEST7003_1389	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BEST7003_1390	COG1733	regulation of RNA biosynthetic process
BEST7003_1391	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1392	COG4641	Protein conserved in bacteria
BEST7003_1392	COG1388	LysM domain
BEST7003_1393	COG1388	LysM domain
BEST7003_1394	COG3858	chitin binding
BEST7003_1395	COG3858	chitin binding
BEST7003_1397	COG4873	Protein conserved in bacteria
BEST7003_1399	COG3773	Cell wall hydrolase
BEST7003_1400	COG2244	polysaccharide biosynthetic process
BEST7003_1401	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_1402	COG2217	Heavy metal translocating P-type atpase
BEST7003_1404	COG0006	proline dipeptidase activity
BEST7003_1406	COG1609	Transcriptional regulator
BEST7003_1407	COG3711	transcriptional antiterminator
BEST7003_1408	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_1408	COG1263	PTS System
BEST7003_1408	COG2190	(PTS) system
BEST7003_1409	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_1410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BEST7003_1412	COG1533	DNA photolyase activity
BEST7003_1413	COG0456	acetyltransferase
BEST7003_1414	COG0840	transmembrane signaling receptor activity
BEST7003_1415	COG2084	Dehydrogenase
BEST7003_1416	COG2340	Cysteine-rich secretory protein family
BEST7003_1417	COG0768	penicillin binding
BEST7003_1418	COG4191	Histidine kinase
BEST7003_1419	COG0436	Aminotransferase
BEST7003_1421	COG0784	Response regulator, receiver
BEST7003_1421	COG0835	chemotaxis
BEST7003_1423	COG2814	Major facilitator Superfamily
BEST7003_1424	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7003_1425	COG1408	metallophosphoesterase
BEST7003_1426	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1427	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_1428	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_1430	COG2200	EAL domain
BEST7003_1431	COG4703	Protein of unknown function (DUF1797)
BEST7003_1432	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BEST7003_1434	COG0517	IMP dehydrogenase activity
BEST7003_1435	COG0583	DNA-binding transcription factor activity
BEST7003_1436	COG0716	FMN binding
BEST7003_1438	COG0716	FMN binding
BEST7003_1439	COG2171	N-acyltransferase activity
BEST7003_1440	COG1473	amidohydrolase
BEST7003_1442	COG0668	transmembrane transport
BEST7003_1443	COG0450	alkyl hydroperoxide reductase
BEST7003_1444	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_1447	COG0746	molybdenum cofactor guanylyltransferase activity
BEST7003_1448	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BEST7003_1449	COG0303	'Molybdopterin
BEST7003_1450	COG1763	Mo-molybdopterin cofactor biosynthetic process
BEST7003_1451	COG0314	molybdopterin synthase activity
BEST7003_1452	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BEST7003_1453	COG1132	(ABC) transporter
BEST7003_1454	COG1132	(ABC) transporter
BEST7003_1456	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7003_1457	COG1136	(ABC) transporter
BEST7003_1458	COG0577	efflux transmembrane transporter activity
BEST7003_1459	COG1349	DNA-binding transcription factor activity
BEST7003_1460	COG1105	Belongs to the carbohydrate kinase PfkB family
BEST7003_1461	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_1461	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_1461	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7003_1462	COG0681	Belongs to the peptidase S26 family
BEST7003_1464	COG0488	(ABC) transporter
BEST7003_1465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BEST7003_1466	COG2309	aminopeptidase activity
BEST7003_1468	COG1077	Cell shape determining protein MreB Mrl
BEST7003_1469	COG2002	toxin-antitoxin pair type II binding
BEST7003_1470	COG3852	Histidine kinase
BEST7003_1471	COG2105	PFAM AIG2 family protein
BEST7003_1471	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BEST7003_1472	COG0569	domain protein
BEST7003_1473	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BEST7003_1474	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BEST7003_1476	COG0561	phosphatase activity
BEST7003_1477	COG0242	peptide deformylase activity
BEST7003_1479	COG0497	DNA recombination
BEST7003_1480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7003_1481	COG0022	dehydrogenase e1 component
BEST7003_1482	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_1483	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7003_1484	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_1485	COG1982	Orn Lys Arg decarboxylase major
BEST7003_1486	COG4476	Belongs to the UPF0223 family
BEST7003_1487	COG4493	Belongs to the UPF0637 family
BEST7003_1489	COG0483	inositol monophosphate 1-phosphatase activity
BEST7003_1491	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BEST7003_1495	COG1595	DNA-templated transcription, initiation
BEST7003_1501	COG4896	Protein conserved in bacteria
BEST7003_1503	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BEST7003_1504	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BEST7003_1505	COG2066	Belongs to the glutaminase family
BEST7003_1506	COG4838	Belongs to the UPF0358 family
BEST7003_1507	COG0772	Belongs to the SEDS family
BEST7003_1508	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BEST7003_1509	COG1612	heme a metabolic process
BEST7003_1510	COG0109	protoheme IX farnesyltransferase activity
BEST7003_1511	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BEST7003_1511	COG2010	Cytochrome c
BEST7003_1512	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7003_1513	COG1845	cytochrome c oxidase, subunit III
BEST7003_1514	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BEST7003_1515	COG3336	cytochrome c oxidase
BEST7003_1517	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BEST7003_1518	COG2340	Cysteine-rich secretory protein family
BEST7003_1521	COG3679	Belongs to the UPF0342 family
BEST7003_1522	COG4471	UPF0298 protein
BEST7003_1523	COG0742	ribosomal rna small subunit methyltransferase
BEST7003_1524	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BEST7003_1525	COG3314	Sporulation integral membrane protein YlbJ
BEST7003_1526	COG1752	Esterase of the alpha-beta hydrolase superfamily
BEST7003_1527	COG3480	Lon protease (S16) C-terminal proteolytic domain
BEST7003_1528	COG1323	Belongs to the UPF0348 family
BEST7003_1529	COG1399	metal-binding, possibly nucleic acid-binding protein
BEST7003_1530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BEST7003_1532	COG0454	-acetyltransferase
BEST7003_1533	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BEST7003_1534	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BEST7003_1535	COG2001	Belongs to the MraZ family
BEST7003_1536	COG0275	rRNA processing
BEST7003_1537	COG4839	cell division protein FtsL
BEST7003_1539	COG0768	penicillin binding
BEST7003_1540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BEST7003_1541	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7003_1542	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BEST7003_1543	COG0772	Belongs to the SEDS family
BEST7003_1544	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7003_1545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BEST7003_1546	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BEST7003_1547	COG3879	Bacterial protein of unknown function (DUF881)
BEST7003_1548	COG3879	Bacterial protein of unknown function (DUF881)
BEST7003_1549	COG3856	small basic protein
BEST7003_1550	COG0849	cell division
BEST7003_1551	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BEST7003_1552	COG4412	M6 family metalloprotease domain protein
BEST7003_1552	COG1404	Belongs to the peptidase S8 family
BEST7003_1554	COG1191	sigma factor activity
BEST7003_1555	COG1191	sigma factor activity
BEST7003_1556	COG1119	ATPase activity
BEST7003_1557	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_1558	COG1873	PFAM PRC-barrel domain
BEST7003_1560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BEST7003_1561	COG1799	cell septum assembly
BEST7003_1562	COG0762	integral membrane protein
BEST7003_1563	COG2302	S4 RNA-binding domain
BEST7003_1564	COG3599	regulation of cell shape
BEST7003_1565	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BEST7003_1566	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7003_1567	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BEST7003_1568	COG0564	pseudouridine synthase activity
BEST7003_1569	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BEST7003_1570	COG2233	PERMEase
BEST7003_1571	COG0540	Belongs to the ATCase OTCase family
BEST7003_1572	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BEST7003_1573	COG0505	Belongs to the CarA family
BEST7003_1574	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7003_1575	COG0543	2 iron, 2 sulfur cluster binding
BEST7003_1576	COG0167	dihydroorotate dehydrogenase activity
BEST7003_1577	COG0284	orotidine-5'-phosphate decarboxylase activity
BEST7003_1578	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BEST7003_1579	COG0175	sulfate reduction
BEST7003_1580	COG0306	phosphate transporter
BEST7003_1581	COG2046	Belongs to the sulfate adenylyltransferase family
BEST7003_1582	COG0529	Catalyzes the synthesis of activated sulfate
BEST7003_1583	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BEST7003_1584	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BEST7003_1585	COG1648	precorrin-2 dehydrogenase activity
BEST7003_1587	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7003_1588	COG1561	YicC-like family, N-terminal region
BEST7003_1589	COG2052	Domain of unknown function (DUF370)
BEST7003_1590	COG0194	GDP metabolic process
BEST7003_1591	COG1758	RNA polymerase activity
BEST7003_1592	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BEST7003_1593	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BEST7003_1594	COG0242	peptide deformylase activity
BEST7003_1595	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BEST7003_1596	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7003_1596	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BEST7003_1597	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BEST7003_1598	COG0631	protein serine/threonine phosphatase activity
BEST7003_1599	COG2815	serine threonine protein kinase
BEST7003_1599	COG0515	serine threonine protein kinase
BEST7003_1600	COG1162	GTPase activity
BEST7003_1601	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BEST7003_1602	COG1564	THIamine pyrophosphokinase
BEST7003_1603	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BEST7003_1604	COG1302	Protein conserved in bacteria
BEST7003_1605	COG1461	Dihydroxyacetone kinase
BEST7003_1606	COG1760	l-serine dehydratase
BEST7003_1607	COG1760	l-serine dehydratase
BEST7003_1608	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BEST7003_1609	COG2050	protein possibly involved in aromatic compounds catabolism
BEST7003_1609	COG1349	DNA-binding transcription factor activity
BEST7003_1610	COG0416	fatty acid biosynthetic process
BEST7003_1611	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7003_1612	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1613	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_1614	COG0571	ribonuclease III activity
BEST7003_1615	COG1196	nuclear chromosome segregation
BEST7003_1616	COG0552	protein localization to endoplasmic reticulum
BEST7003_1618	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BEST7003_1619	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BEST7003_1620	COG0228	four-way junction DNA binding
BEST7003_1621	COG1837	Belongs to the UPF0109 family
BEST7003_1623	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BEST7003_1624	COG0336	Belongs to the RNA methyltransferase TrmD family
BEST7003_1625	COG0335	large ribosomal subunit rRNA binding
BEST7003_1626	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BEST7003_1627	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BEST7003_1629	COG2257	FlhB HrpN YscU SpaS Family
BEST7003_1630	COG0045	succinate-CoA ligase (ADP-forming) activity
BEST7003_1631	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BEST7003_1632	COG0758	DNA mediated transformation
BEST7003_1633	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BEST7003_1634	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BEST7003_1635	COG4974	Belongs to the 'phage' integrase family
BEST7003_1636	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BEST7003_1637	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BEST7003_1638	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BEST7003_1639	COG1815	bacterial-type flagellum-dependent cell motility
BEST7003_1640	COG1558	bacterial-type flagellum-dependent cell motility
BEST7003_1641	COG1677	Flagellar hook-basal body complex protein FliE
BEST7003_1642	COG1766	The M ring may be actively involved in energy transduction
BEST7003_1643	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7003_1644	COG1317	bacterial-type flagellum organization
BEST7003_1645	COG1157	protein secretion by the type III secretion system
BEST7003_1646	COG2882	bacterial-type flagellum organization
BEST7003_1647	COG3334	PFAM MgtE intracellular
BEST7003_1648	COG3144	bacterial-type flagellum assembly
BEST7003_1649	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BEST7003_1650	COG4786	Flagellar basal body rod
BEST7003_1651	COG1582	Flagellar protein (FlbD)
BEST7003_1652	COG1580	Controls the rotational direction of flagella during chemotaxis
BEST7003_1653	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7003_1654	COG1776	CheC inhibitor of MCP methylation
BEST7003_1654	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7003_1655	COG2201	protein-glutamate methylesterase activity
BEST7003_1656	COG3190	flagellar
BEST7003_1657	COG1338	Plays a role in the flagellum-specific transport system
BEST7003_1658	COG1987	bacterial-type flagellum assembly
BEST7003_1659	COG1684	flagellar biosynthetic protein fliR
BEST7003_1660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BEST7003_1661	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BEST7003_1662	COG1419	protein localization to endoplasmic reticulum
BEST7003_1663	COG0455	bacterial-type flagellum organization
BEST7003_1664	COG2201	protein-glutamate methylesterase activity
BEST7003_1665	COG0643	Histidine kinase
BEST7003_1665	COG2198	Histidine kinase
BEST7003_1666	COG0835	chemotaxis
BEST7003_1667	COG1776	CheC inhibitor of MCP methylation
BEST7003_1668	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BEST7003_1669	COG1191	sigma factor activity
BEST7003_1671	COG0052	Belongs to the universal ribosomal protein uS2 family
BEST7003_1672	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BEST7003_1673	COG0528	UMP kinase activity
BEST7003_1674	COG0233	cytoplasmic translational termination
BEST7003_1675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BEST7003_1676	COG4589	Belongs to the CDS family
BEST7003_1677	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BEST7003_1678	COG0750	zinc metalloprotease
BEST7003_1679	COG0442	prolyl-tRNA aminoacylation
BEST7003_1680	COG2176	DNA-directed DNA polymerase activity
BEST7003_1681	COG0779	Required for maturation of 30S ribosomal subunits
BEST7003_1682	COG0195	Participates in both transcription termination and antitermination
BEST7003_1683	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BEST7003_1684	COG1358	cellular component organization or biogenesis
BEST7003_1685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BEST7003_1686	COG1550	Protein conserved in bacteria
BEST7003_1687	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BEST7003_1688	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BEST7003_1689	COG0196	riboflavin kinase activity
BEST7003_1690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BEST7003_1691	COG1185	polyribonucleotide nucleotidyltransferase activity
BEST7003_1692	COG0726	polysaccharide deacetylase
BEST7003_1693	COG0612	Peptidase, M16
BEST7003_1694	COG1873	PFAM PRC-barrel domain
BEST7003_1695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BEST7003_1696	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BEST7003_1697	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BEST7003_1698	COG0527	aspartate kinase activity
BEST7003_1699	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BEST7003_1700	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BEST7003_1701	COG0740	serine-type endopeptidase activity
BEST7003_1703	COG1674	ftsk spoiiie
BEST7003_1703	COG4980	gas vesicle protein
BEST7003_1704	COG2188	Transcriptional regulator
BEST7003_1705	COG2814	Major facilitator Superfamily
BEST7003_1706	COG0612	Peptidase, M16
BEST7003_1707	COG0612	Peptidase, M16
BEST7003_1708	COG0300	oxidoreductase activity
BEST7003_1712	COG1426	Protein conserved in bacteria
BEST7003_1713	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BEST7003_1714	COG1546	Belongs to the CinA family
BEST7003_1714	COG1058	Belongs to the CinA family
BEST7003_1715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BEST7003_1716	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7003_1717	COG1418	mRNA catabolic process
BEST7003_1718	COG1692	metallophosphoesterase
BEST7003_1719	COG2359	stage V sporulation protein S
BEST7003_1720	COG1063	alcohol dehydrogenase
BEST7003_1721	COG0156	8-amino-7-oxononanoate synthase activity
BEST7003_1722	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7003_1723	COG4550	Control of competence regulator ComK, YlbF/YmcA
BEST7003_1725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BEST7003_1726	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BEST7003_1729	COG3226	Transcriptional regulator
BEST7003_1730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_1731	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7003_1732	COG3321	synthase
BEST7003_1733	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7003_1733	COG2070	2-Nitropropane dioxygenase
BEST7003_1734	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_1735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7003_1736	COG3425	synthase
BEST7003_1737	COG1024	Enoyl-CoA hydratase
BEST7003_1738	COG1024	Enoyl-CoA hydratase
BEST7003_1739	COG0300	oxidoreductase activity
BEST7003_1739	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_1739	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1739	COG3321	synthase
BEST7003_1739	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1740	COG0300	oxidoreductase activity
BEST7003_1740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_1740	COG3321	synthase
BEST7003_1740	COG4221	oxidoreductase activity
BEST7003_1741	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1741	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_1741	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_1741	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1741	COG3321	synthase
BEST7003_1742	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1742	COG4221	oxidoreductase activity
BEST7003_1742	COG3321	synthase
BEST7003_1742	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1743	COG4221	oxidoreductase activity
BEST7003_1743	COG3321	synthase
BEST7003_1743	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1743	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_1744	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BEST7003_1744	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_1744	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BEST7003_1744	COG3321	synthase
BEST7003_1745	COG2124	cytochrome p450
BEST7003_1747	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_1748	COG1404	Belongs to the peptidase S8 family
BEST7003_1749	COG4195	phage-related replication protein
BEST7003_1750	COG1764	response to oxidative stress
BEST7003_1751	COG2076	Multidrug Resistance protein
BEST7003_1752	COG2076	Multidrug Resistance protein
BEST7003_1755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BEST7003_1756	COG1923	regulation of RNA biosynthetic process
BEST7003_1759	COG1780	Probably involved in ribonucleotide reductase function
BEST7003_1760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7003_1761	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7003_1762	COG4112	unkown
BEST7003_1763	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_1764	COG0464	growth
BEST7003_1765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BEST7003_1766	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BEST7003_1767	COG0789	Transcriptional regulator
BEST7003_1768	COG0174	glutamine synthetase
BEST7003_1772	COG4282	regulation of fungal-type cell wall biogenesis
BEST7003_1774	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_1779	COG0135	phosphoribosylanthranilate isomerase activity
BEST7003_1780	COG2211	Major facilitator Superfamily
BEST7003_1781	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_1782	COG1940	carbohydrate kinase activity
BEST7003_1783	COG2115	Belongs to the xylose isomerase family
BEST7003_1784	COG1070	Carbohydrate kinase
BEST7003_1785	COG1525	nuclease
BEST7003_1786	COG2814	Major facilitator Superfamily
BEST7003_1787	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BEST7003_1789	COG0756	dUTP diphosphatase activity
BEST7003_1793	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BEST7003_1798	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7003_1800	COG3832	glyoxalase III activity
BEST7003_1802	COG0697	spore germination
BEST7003_1803	COG0531	amino acid
BEST7003_1809	COG4195	phage-related replication protein
BEST7003_1811	COG0346	lactoylglutathione lyase activity
BEST7003_1812	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BEST7003_1813	COG1388	LysM domain
BEST7003_1814	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_1815	COG4224	UPF0291 protein
BEST7003_1816	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BEST7003_1818	COG3763	UPF0154 protein
BEST7003_1820	COG0785	Cytochrome C biogenesis protein
BEST7003_1821	COG2201	protein-glutamate methylesterase activity
BEST7003_1822	COG4846	Membrane protein involved in cytochrome C biogenesis
BEST7003_1824	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_1827	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BEST7003_1828	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_1832	COG0824	Thioesterase
BEST7003_1834	COG4841	protein insertion into membrane
BEST7003_1835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BEST7003_1836	COG1832	CoA-binding protein
BEST7003_1837	COG0187	DNA topoisomerase II activity
BEST7003_1838	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7003_1841	COG1115	amino acid carrier protein
BEST7003_1844	COG5520	Belongs to the glycosyl hydrolase 30 family
BEST7003_1845	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_1846	COG2246	polysaccharide biosynthetic process
BEST7003_1847	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7003_1848	COG0586	Pfam SNARE associated Golgi protein
BEST7003_1849	COG2404	hydrolase activity, acting on ester bonds
BEST7003_1850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BEST7003_1851	COG1024	Enoyl-CoA hydratase
BEST7003_1852	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7003_1853	COG0511	ligase activity, forming carbon-carbon bonds
BEST7003_1854	COG0439	Biotin carboxylase
BEST7003_1855	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_1856	COG1960	acyl-CoA dehydrogenase activity
BEST7003_1858	COG1649	PFAM Uncharacterised BCR, COG1649
BEST7003_1860	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BEST7003_1860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1861	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1862	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1863	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_1864	COG2027	D-alanyl-D-alanine carboxypeptidase
BEST7003_1865	COG2017	converts alpha-aldose to the beta-anomer
BEST7003_1866	COG0534	Mate efflux family protein
BEST7003_1868	COG0582	viral genome integration into host DNA
BEST7003_1869	COG0166	Belongs to the GPI family
BEST7003_1870	COG0405	Gamma-glutamyltransferase
BEST7003_1871	COG0583	DNA-binding transcription factor activity
BEST7003_1872	COG0604	alcohol dehydrogenase
BEST7003_1873	COG0493	'glutamate synthase
BEST7003_1874	COG0067	glutamate synthase
BEST7003_1874	COG0069	glutamate synthase activity
BEST7003_1874	COG0070	glutamate synthase
BEST7003_1875	COG0583	DNA-binding transcription factor activity
BEST7003_1876	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7003_1877	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_1879	COG0300	oxidoreductase activity
BEST7003_1880	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BEST7003_1882	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7003_1883	COG2814	Major facilitator Superfamily
BEST7003_1884	COG1070	Carbohydrate kinase
BEST7003_1885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BEST7003_1886	COG0243	molybdopterin cofactor binding
BEST7003_1891	COG0840	transmembrane signaling receptor activity
BEST7003_1891	COG5278	phosphoserine phosphatase activity
BEST7003_1892	COG2368	4-hydroxyphenylacetate
BEST7003_1893	COG4305	rare lipoprotein A
BEST7003_1894	COG3619	membrane
BEST7003_1895	COG3866	Pectate lyase
BEST7003_1896	COG2135	peptidase activity
BEST7003_1898	COG2140	Oxalate decarboxylase
BEST7003_1900	COG0456	acetyltransferase
BEST7003_1903	COG2720	vancomycin resistance protein
BEST7003_1905	COG3655	Transcriptional regulator
BEST7003_1906	COG3739	integral membrane protein
BEST7003_1907	COG0583	DNA-binding transcription factor activity
BEST7003_1908	COG0697	spore germination
BEST7003_1910	COG0693	protein deglycase activity
BEST7003_1911	COG2367	Beta-lactamase
BEST7003_1915	COG3848	Pyruvate phosphate dikinase
BEST7003_1915	COG0574	Belongs to the PEP-utilizing enzyme family
BEST7003_1916	COG0726	polysaccharide deacetylase
BEST7003_1917	COG2314	TM2 domain
BEST7003_1918	COG1396	sequence-specific DNA binding
BEST7003_1921	COG2135	peptidase activity
BEST7003_1927	COG0457	Tetratricopeptide repeat
BEST7003_1929	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_1930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_1933	COG5290	Psort location Cytoplasmic, score
BEST7003_1937	COG5444	nuclease activity
BEST7003_1938	COG4282	regulation of fungal-type cell wall biogenesis
BEST7003_1939	COG1231	oxidoreductase activity
BEST7003_1940	COG5434	Belongs to the glycosyl hydrolase 28 family
BEST7003_1941	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_1942	COG0662	Cupin 2, conserved barrel domain protein
BEST7003_1942	COG2207	Transcriptional regulator
BEST7003_1943	COG0456	acetyltransferase
BEST7003_1944	COG1309	transcriptional regulator
BEST7003_1945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_1946	COG3708	Transcriptional regulator
BEST7003_1947	COG2378	regulation of single-species biofilm formation
BEST7003_1949	COG0640	Transcriptional regulator
BEST7003_1950	COG0741	lytic transglycosylase activity
BEST7003_1951	COG2322	membrane
BEST7003_1954	COG1619	proteins homologs of microcin C7 resistance protein MccF
BEST7003_1955	COG3239	Fatty acid desaturase
BEST7003_1956	COG4585	Histidine kinase
BEST7003_1957	COG2197	response regulator
BEST7003_1958	COG1388	LysM domain
BEST7003_1958	COG3584	3D domain protein
BEST7003_1959	COG0514	ATP-dependent DNA helicase (RecQ)
BEST7003_1960	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BEST7003_1961	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7003_1964	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_1969	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_1970	COG1657	PFAM Prenyltransferase squalene oxidase
BEST7003_1971	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BEST7003_1972	COG0733	neurotransmitter:sodium symporter activity
BEST7003_1973	COG0385	Bile acid
BEST7003_1974	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_1975	COG0567	Dehydrogenase, E1 component
BEST7003_1976	COG4548	von Willebrand factor, type A
BEST7003_1977	COG0714	Associated with various cellular activities
BEST7003_1978	COG2032	superoxide dismutase activity
BEST7003_1979	COG0791	NLP P60 protein
BEST7003_1979	COG1388	LysM domain
BEST7003_1980	COG1819	glycosyl
BEST7003_1981	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BEST7003_1982	COG0534	Mate efflux family protein
BEST7003_1983	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_1984	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7003_1985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7003_1987	COG2962	Rard protein
BEST7003_1990	COG2610	gluconate transmembrane transporter activity
BEST7003_1991	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_1992	COG1733	regulation of RNA biosynthetic process
BEST7003_1993	COG0778	Nitroreductase
BEST7003_1994	COG0400	carboxylic ester hydrolase activity
BEST7003_1995	COG0346	lactoylglutathione lyase activity
BEST7003_1997	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_1998	COG0793	Belongs to the peptidase S41A family
BEST7003_1998	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_1999	COG2226	methyltransferase
BEST7003_2001	COG1876	peptidase activity
BEST7003_2002	COG0813	purine-nucleoside phosphorylase activity
BEST7003_2005	COG0671	phosphoesterase, PA-phosphatase related
BEST7003_2009	COG4479	Belongs to the UPF0346 family
BEST7003_2011	COG1509	lysine 2,3-aminomutase activity
BEST7003_2012	COG0456	acetyltransferase
BEST7003_2013	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_2014	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BEST7003_2015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BEST7003_2016	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7003_2017	COG0456	acetyltransferase
BEST7003_2018	COG0463	Glycosyl transferase, family 2
BEST7003_2021	COG4641	Protein conserved in bacteria
BEST7003_2022	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
BEST7003_2023	COG1086	Polysaccharide biosynthesis protein
BEST7003_2024	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7003_2025	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7003_2026	COG1846	Transcriptional regulator
BEST7003_2027	COG0534	Mate efflux family protein
BEST7003_2029	COG4698	Protein conserved in bacteria
BEST7003_2030	COG2755	lipolytic protein G-D-S-L family
BEST7003_2031	COG1999	signal sequence binding
BEST7003_2033	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BEST7003_2034	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BEST7003_2035	COG1272	protein, Hemolysin III
BEST7003_2036	COG0204	Acyl-transferase
BEST7003_2037	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7003_2038	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BEST7003_2039	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BEST7003_2041	COG2136	Putative SAM-dependent methyltransferase
BEST7003_2041	COG2521	methyltransferase
BEST7003_2043	COG0129	dihydroxy-acid dehydratase activity
BEST7003_2044	COG1413	lyase activity
BEST7003_2045	COG1418	mRNA catabolic process
BEST7003_2046	COG0386	Belongs to the glutathione peroxidase family
BEST7003_2047	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BEST7003_2048	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7003_2049	COG1278	Cold shock
BEST7003_2053	COG0328	RNA-DNA hybrid ribonuclease activity
BEST7003_2054	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BEST7003_2055	COG0328	RNA-DNA hybrid ribonuclease activity
BEST7003_2057	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7003_2060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BEST7003_2061	COG1755	Isoprenylcysteine carboxyl methyltransferase
BEST7003_2062	COG3424	synthase
BEST7003_2063	COG2233	PERMEase
BEST7003_2064	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7003_2065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BEST7003_2067	COG0800	Aldolase
BEST7003_2068	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_2069	COG1609	Transcriptional regulator
BEST7003_2070	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BEST7003_2071	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_2072	COG1199	ATP-dependent helicase activity
BEST7003_2074	COG0116	Belongs to the methyltransferase superfamily
BEST7003_2076	COG4474	Belongs to the UPF0398 family
BEST7003_2077	COG3359	exonuclease
BEST7003_2078	COG1111	helicase
BEST7003_2078	COG1205	dead DEAH box helicase
BEST7003_2079	COG2190	(PTS) system
BEST7003_2080	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7003_2086	COG3331	DNA recombination
BEST7003_2087	COG4499	WXG100 protein secretion system (Wss), protein YukC
BEST7003_2087	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_2089	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BEST7003_2090	COG3935	DnaD domain protein
BEST7003_2091	COG0017	Asparaginyl-tRNA synthetase
BEST7003_2092	COG0436	Aminotransferase
BEST7003_2093	COG5353	protein conserved in bacteria
BEST7003_2095	COG1199	ATP-dependent helicase activity
BEST7003_2095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BEST7003_2096	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BEST7003_2097	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BEST7003_2098	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BEST7003_2099	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BEST7003_2099	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BEST7003_2100	COG0617	tRNA 3'-terminal CCA addition
BEST7003_2101	COG0438	transferase activity, transferring glycosyl groups
BEST7003_2102	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7003_2103	COG1803	Methylglyoxal synthase
BEST7003_2104	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BEST7003_2105	COG1694	Mazg nucleotide pyrophosphohydrolase
BEST7003_2106	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_2108	COG4347	Protein of unknown function (DUF1405)
BEST7003_2109	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7003_2109	COG2010	Cytochrome c
BEST7003_2110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7003_2111	COG0723	plastoquinol--plastocyanin reductase activity
BEST7003_2113	COG5582	Belongs to the UPF0302 family
BEST7003_2114	COG0457	Tetratricopeptide repeat
BEST7003_2115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BEST7003_2116	COG0287	Prephenate dehydrogenase
BEST7003_2117	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BEST7003_2118	COG0159	tryptophan synthase activity
BEST7003_2119	COG0133	tryptophan synthase activity
BEST7003_2120	COG0135	phosphoribosylanthranilate isomerase activity
BEST7003_2122	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BEST7003_2123	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7003_2124	COG4401	Chorismate mutase type I
BEST7003_2125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BEST7003_2126	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BEST7003_2127	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BEST7003_2128	COG0105	UTP biosynthetic process
BEST7003_2129	COG0142	geranyltranstransferase activity
BEST7003_2130	COG2226	methyltransferase
BEST7003_2131	COG0142	geranyltranstransferase activity
BEST7003_2133	COG0302	gtp cyclohydrolase
BEST7003_2134	COG0776	regulation of translation
BEST7003_2135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BEST7003_2138	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BEST7003_2139	COG1160	GTP binding
BEST7003_2144	COG1304	FMN binding
BEST7003_2145	COG0539	negative regulation of cytoplasmic translation
BEST7003_2146	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BEST7003_2148	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BEST7003_2149	COG2959	enzyme of heme biosynthesis
BEST7003_2150	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_2150	COG3773	Cell wall hydrolase
BEST7003_2151	COG2339	peptidase activity
BEST7003_2152	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_2153	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7003_2154	COG4862	establishment of competence for transformation
BEST7003_2155	COG1408	metallophosphoesterase
BEST7003_2156	COG1388	LysM domain
BEST7003_2157	COG1266	CAAX protease self-immunity
BEST7003_2158	COG0514	ATP-dependent DNA helicase (RecQ)
BEST7003_2159	COG4955	Helix-turn-helix domain
BEST7003_2160	COG1141	Ferredoxin
BEST7003_2161	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BEST7003_2163	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BEST7003_2164	COG0710	3-dehydroquinate dehydratase activity
BEST7003_2166	COG1595	DNA-templated transcription, initiation
BEST7003_2167	COG5002	protein histidine kinase activity
BEST7003_2168	COG0745	RESPONSE REGULATOR receiver
BEST7003_2169	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BEST7003_2170	COG1333	cytochrome c biogenesis protein
BEST7003_2171	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_2172	COG1187	pseudouridine synthase activity
BEST7003_2173	COG0700	Nucleoside recognition
BEST7003_2174	COG2715	membrane protein required for spore maturation
BEST7003_2175	COG1686	Belongs to the peptidase S11 family
BEST7003_2177	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BEST7003_2178	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BEST7003_2179	COG1547	Domain of unknown function (DUF309)
BEST7003_2180	COG0456	acetyltransferase
BEST7003_2181	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BEST7003_2182	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7003_2182	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7003_2183	COG0307	riboflavin synthase, alpha
BEST7003_2184	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7003_2184	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7003_2186	COG0681	Belongs to the peptidase S26 family
BEST7003_2188	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BEST7003_2191	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BEST7003_2192	COG4086	secreted protein
BEST7003_2193	COG0019	diaminopimelate decarboxylase activity
BEST7003_2194	COG0697	spore germination
BEST7003_2197	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7003_2201	COG1191	sigma factor activity
BEST7003_2202	COG2172	sigma factor antagonist activity
BEST7003_2203	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_2204	COG1686	Belongs to the peptidase S11 family
BEST7003_2205	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BEST7003_2206	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BEST7003_2207	COG4974	Belongs to the 'phage' integrase family
BEST7003_2209	COG0735	belongs to the Fur family
BEST7003_2210	COG1300	Membrane
BEST7003_2212	COG0281	malic enzyme
BEST7003_2213	COG1757	Na H antiporter
BEST7003_2214	COG1027	Aspartate ammonia-lyase
BEST7003_2215	COG0252	asparaginase activity
BEST7003_2216	COG1396	sequence-specific DNA binding
BEST7003_2217	COG1379	DNA repair
BEST7003_2218	COG0494	nUDIX hydrolase
BEST7003_2220	COG0667	Aldo Keto reductase
BEST7003_2222	COG1073	alpha beta
BEST7003_2224	COG4918	Iron-sulphur cluster biosynthesis
BEST7003_2225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BEST7003_2225	COG0456	acetyltransferase
BEST7003_2226	COG2329	Antibiotic biosynthesis monooxygenase
BEST7003_2227	COG0456	acetyltransferase
BEST7003_2229	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_2231	COG2211	Major facilitator Superfamily
BEST7003_2233	COG0346	lactoylglutathione lyase activity
BEST7003_2234	COG1072	(Pantothenic acid kinase))
BEST7003_2235	COG3048	D-serine ammonia-lyase activity
BEST7003_2236	COG0300	oxidoreductase activity
BEST7003_2237	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_2238	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_2239	COG4187	Peptidase family M20/M25/M40
BEST7003_2240	COG1902	pentaerythritol trinitrate reductase activity
BEST7003_2241	COG0596	Alpha beta hydrolase
BEST7003_2242	COG1234	tRNA 3'-trailer cleavage
BEST7003_2243	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BEST7003_2244	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BEST7003_2245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7003_2247	COG0706	membrane insertase activity
BEST7003_2248	COG3361	conserved protein (COG2071)
BEST7003_2249	COG2195	Cleaves the N-terminal amino acid of tripeptides
BEST7003_2250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BEST7003_2251	COG0346	lactoylglutathione lyase activity
BEST7003_2252	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7003_2253	COG4129	membrane
BEST7003_2254	COG1126	abc transporter atp-binding protein
BEST7003_2255	COG0765	amino acid transport
BEST7003_2256	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_2258	COG1597	lipid kinase activity
BEST7003_2259	COG2814	Major facilitator Superfamily
BEST7003_2260	COG0789	Transcriptional regulator
BEST7003_2260	COG4978	Transcriptional regulator
BEST7003_2261	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7003_2262	COG0022	dehydrogenase e1 component
BEST7003_2263	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7003_2264	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7003_2265	COG3426	butyrate kinase activity
BEST7003_2266	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7003_2267	COG0280	phosphate acetyltransferase
BEST7003_2268	COG3829	transcription factor binding
BEST7003_2268	COG3290	protein histidine kinase activity
BEST7003_2270	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BEST7003_2271	COG2079	MmgE PrpD family protein
BEST7003_2272	COG0372	Belongs to the citrate synthase family
BEST7003_2273	COG1960	acyl-CoA dehydrogenase activity
BEST7003_2274	COG1250	3-hydroxyacyl-CoA dehydrogenase
BEST7003_2275	COG0183	Belongs to the thiolase family
BEST7003_2276	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7003_2277	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_2279	COG1902	pentaerythritol trinitrate reductase activity
BEST7003_2280	COG0745	RESPONSE REGULATOR receiver
BEST7003_2281	COG0750	zinc metalloprotease
BEST7003_2282	COG0497	DNA recombination
BEST7003_2283	COG1438	arginine binding
BEST7003_2284	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BEST7003_2285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BEST7003_2286	COG0142	geranyltranstransferase activity
BEST7003_2287	COG1722	exodeoxyribonuclease VII activity
BEST7003_2288	COG1570	exodeoxyribonuclease VII activity
BEST7003_2289	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BEST7003_2290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7003_2291	COG1302	Protein conserved in bacteria
BEST7003_2292	COG0439	Biotin carboxylase
BEST7003_2293	COG0511	ligase activity, forming carbon-carbon bonds
BEST7003_2301	COG3854	ATPases associated with a variety of cellular activities
BEST7003_2303	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BEST7003_2304	COG0006	proline dipeptidase activity
BEST7003_2305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BEST7003_2307	COG3872	metal-dependent enzyme
BEST7003_2309	COG1752	Esterase of the alpha-beta hydrolase superfamily
BEST7003_2310	COG1321	iron dependent repressor
BEST7003_2311	COG0095	Lipoate-protein ligase
BEST7003_2312	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_2313	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7003_2314	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7003_2315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BEST7003_2316	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BEST7003_2319	COG1396	sequence-specific DNA binding
BEST7003_2321	COG0681	Belongs to the peptidase S26 family
BEST7003_2327	COG4940	Competence protein ComGF
BEST7003_2329	COG4970	Tfp pilus assembly protein FimT
BEST7003_2330	COG4537	Required for transformation and DNA binding
BEST7003_2331	COG1459	type II secretion system
BEST7003_2332	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BEST7003_2333	COG0598	Magnesium transport protein CorA
BEST7003_2334	COG1253	flavin adenine dinucleotide binding
BEST7003_2335	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_2336	COG1393	Belongs to the ArsC family
BEST7003_2338	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_2340	COG0011	TIGRFAM Protein of
BEST7003_2342	COG2866	Carboxypeptidase
BEST7003_2343	COG1368	sulfuric ester hydrolase activity
BEST7003_2344	COG1940	carbohydrate kinase activity
BEST7003_2345	COG4483	Protein conserved in bacteria
BEST7003_2346	COG0705	Rhomboid family
BEST7003_2346	COG0457	Tetratricopeptide repeat
BEST7003_2348	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BEST7003_2349	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BEST7003_2350	COG0438	transferase activity, transferring glycosyl groups
BEST7003_2353	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BEST7003_2354	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7003_2355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7003_2356	COG0581	inorganic phosphate transmembrane transporter activity
BEST7003_2357	COG0573	inorganic phosphate transmembrane transporter activity
BEST7003_2358	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7003_2360	COG0477	Major facilitator Superfamily
BEST7003_2361	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BEST7003_2362	COG2839	Protein conserved in bacteria
BEST7003_2363	COG5521	maltodextrose utilization protein MalA
BEST7003_2365	COG1388	LysM domain
BEST7003_2366	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BEST7003_2367	COG4709	membrane
BEST7003_2368	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BEST7003_2369	COG0735	belongs to the Fur family
BEST7003_2370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_2372	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BEST7003_2373	COG0513	Belongs to the DEAD box helicase family
BEST7003_2375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BEST7003_2376	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BEST7003_2377	COG2384	SAM-dependent methyltransferase
BEST7003_2378	COG2010	Cytochrome c
BEST7003_2379	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7003_2380	COG0358	DNA primase activity
BEST7003_2381	COG1671	Belongs to the UPF0178 family
BEST7003_2382	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BEST7003_2383	COG0517	IMP dehydrogenase activity
BEST7003_2384	COG0751	glycine-tRNA ligase activity
BEST7003_2385	COG0752	glycyl-tRNA synthetase alpha subunit
BEST7003_2386	COG1381	Involved in DNA repair and RecF pathway recombination
BEST7003_2388	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BEST7003_2389	COG0295	cytidine deaminase activity
BEST7003_2390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BEST7003_2391	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BEST7003_2392	COG1480	7TM receptor with intracellular HD hydrolase
BEST7003_2393	COG1702	phosphate starvation-inducible protein PhoH
BEST7003_2394	COG0561	phosphatase activity
BEST7003_2397	COG4864	UPF0365 protein
BEST7003_2398	COG1030	water channel activity
BEST7003_2399	COG1610	YqeY-like protein
BEST7003_2400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BEST7003_2401	COG1283	sodium-dependent phosphate transmembrane transporter activity
BEST7003_2402	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7003_2403	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BEST7003_2404	COG2264	protein methyltransferase activity
BEST7003_2405	COG0484	heat shock protein binding
BEST7003_2406	COG0443	Heat shock 70 kDa protein
BEST7003_2407	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BEST7003_2408	COG1420	regulation of RNA biosynthetic process
BEST7003_2409	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7003_2410	COG0481	GTPase activity
BEST7003_2412	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_2413	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BEST7003_2415	COG0268	Binds directly to 16S ribosomal RNA
BEST7003_2416	COG1466	dna polymerase III delta subunit
BEST7003_2418	COG2333	competence protein COMEC
BEST7003_2418	COG0658	competence protein
BEST7003_2419	COG2131	deaminase
BEST7003_2420	COG1555	photosystem II stabilization
BEST7003_2420	COG1596	polysaccharide export
BEST7003_2421	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7003_2422	COG2226	methyltransferase
BEST7003_2423	COG0799	negative regulation of ribosome biogenesis
BEST7003_2424	COG1713	HD superfamily hydrolase involved in NAD metabolism
BEST7003_2425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BEST7003_2426	COG1534	Rna-binding protein
BEST7003_2427	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BEST7003_2428	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BEST7003_2429	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BEST7003_2430	COG2755	lipolytic protein G-D-S-L family
BEST7003_2431	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_2431	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_2432	COG0398	Pfam SNARE associated Golgi protein
BEST7003_2433	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BEST7003_2435	COG3209	COG3209 Rhs family protein
BEST7003_2437	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7003_2439	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7003_2440	COG0798	PFAM Bile acid sodium symporter
BEST7003_2441	COG0346	lactoylglutathione lyase activity
BEST7003_2442	COG0640	Transcriptional regulator
BEST7003_2443	COG3403	YqcI/YcgG family
BEST7003_2444	COG0457	Tetratricopeptide repeat
BEST7003_2447	COG5444	nuclease activity
BEST7003_2452	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7003_2452	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_2453	COG4824	toxin secretion phage lysis holin
BEST7003_2459	COG3778	Protein conserved in bacteria
BEST7003_2460	COG3299	homolog of phage Mu protein gp47
BEST7003_2461	COG3628	GPW Gp25 family protein
BEST7003_2463	COG4193	domain, Protein
BEST7003_2464	COG1652	LysM domain
BEST7003_2465	COG3953	SLT domain
BEST7003_2465	COG5280	Phage tail tape measure protein TP901
BEST7003_2478	COG4653	Phage capsid family
BEST7003_2479	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BEST7003_2481	COG2369	cell adhesion
BEST7003_2482	COG5518	Phage portal protein
BEST7003_2483	COG1783	phage Terminase large subunit
BEST7003_2484	COG5484	DNA packaging
BEST7003_2486	COG3677	Transposase
BEST7003_2489	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BEST7003_2491	COG1484	DNA-dependent DNA replication
BEST7003_2492	COG3935	DnaD domain protein
BEST7003_2493	COG3723	Recombinational DNA repair protein, rece pathway
BEST7003_2494	COG5377	YqaJ viral recombinase family
BEST7003_2500	COG1476	TRANSCRIPTIONal
BEST7003_2501	COG3620	sequence-specific DNA binding
BEST7003_2503	COG0563	adenylate kinase activity
BEST7003_2504	COG2856	Zn peptidase
BEST7003_2506	COG3223	Belongs to the PsiE family
BEST7003_2507	COG5002	protein histidine kinase activity
BEST7003_2507	COG0642	Histidine kinase
BEST7003_2508	COG0745	RESPONSE REGULATOR receiver
BEST7003_2509	COG2311	Membrane
BEST7003_2510	COG0454	-acetyltransferase
BEST7003_2511	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7003_2513	COG0730	response to heat
BEST7003_2514	COG0425	Belongs to the sulfur carrier protein TusA family
BEST7003_2515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_2515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_2516	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_2516	COG0425	Belongs to the sulfur carrier protein TusA family
BEST7003_2517	COG2210	Belongs to the sulfur carrier protein TusA family
BEST7003_2518	COG1937	Protein conserved in bacteria
BEST7003_2521	COG0662	Cupin 2, conserved barrel domain protein
BEST7003_2523	COG0789	Transcriptional regulator
BEST7003_2523	COG4978	Transcriptional regulator
BEST7003_2524	COG2814	Major facilitator Superfamily
BEST7003_2525	COG0456	acetyltransferase
BEST7003_2526	COG1253	flavin adenine dinucleotide binding
BEST7003_2528	COG0697	spore germination
BEST7003_2529	COG0583	DNA-binding transcription factor activity
BEST7003_2530	COG2072	flavoprotein involved in K transport
BEST7003_2531	COG1230	cation diffusion facilitator family transporter
BEST7003_2532	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_2533	COG0583	DNA-binding transcription factor activity
BEST7003_2535	COG1114	Component of the transport system for branched-chain amino acids
BEST7003_2536	COG1687	branched-chain amino acid
BEST7003_2537	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BEST7003_2538	COG1522	sequence-specific DNA binding
BEST7003_2539	COG2732	(Barnase) inhibitor
BEST7003_2540	COG2124	cytochrome p450
BEST7003_2543	COG1335	isochorismatase
BEST7003_2545	COG2318	DinB family
BEST7003_2547	COG2070	2-Nitropropane dioxygenase
BEST7003_2550	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BEST7003_2553	COG3443	Belongs to the bacterial solute-binding protein 9 family
BEST7003_2554	COG1595	DNA-templated transcription, initiation
BEST7003_2555	COG0667	Aldo Keto reductase
BEST7003_2556	COG2851	Citrate transporter
BEST7003_2557	COG0583	DNA-binding transcription factor activity
BEST7003_2558	COG2828	Protein conserved in bacteria
BEST7003_2560	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_2561	COG5566	PFAM Mor transcription activator
BEST7003_2562	COG0596	Alpha beta hydrolase
BEST7003_2563	COG4991	sh3 domain protein
BEST7003_2564	COG4991	sh3 domain protein
BEST7003_2565	COG0346	lactoylglutathione lyase activity
BEST7003_2567	COG5577	PFAM Coat F domain
BEST7003_2568	COG1063	alcohol dehydrogenase
BEST7003_2570	COG5577	PFAM Coat F domain
BEST7003_2571	COG0789	Transcriptional regulator
BEST7003_2573	COG1064	alcohol dehydrogenase
BEST7003_2574	COG0693	protein deglycase activity
BEST7003_2575	COG1621	beta-fructofuranosidase activity
BEST7003_2576	COG3716	PTS system mannose fructose sorbose family IID component
BEST7003_2577	COG3715	PTS system
BEST7003_2578	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_2579	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_2580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BEST7003_2580	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BEST7003_2581	COG1113	amino acid transport
BEST7003_2582	COG1280	lysine exporter protein (LysE YggA)
BEST7003_2583	COG1378	Sugar-specific transcriptional regulator TrmB
BEST7003_2584	COG1595	DNA-templated transcription, initiation
BEST7003_2586	COG2755	lipolytic protein G-D-S-L family
BEST7003_2586	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BEST7003_2588	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7003_2588	COG2124	cytochrome p450
BEST7003_2589	COG1309	transcriptional regulator
BEST7003_2590	COG2226	methyltransferase
BEST7003_2592	COG2116	formate transmembrane transporter activity
BEST7003_2593	COG5609	conserved protein (DUF2294)
BEST7003_2594	COG3383	formate dehydrogenase (NAD+) activity
BEST7003_2595	COG2427	Protein of unknown function (DUF1641)
BEST7003_2597	COG0626	cystathionine gamma-synthase activity
BEST7003_2598	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7003_2599	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BEST7003_2600	COG2226	methyltransferase
BEST7003_2603	COG0768	penicillin binding
BEST7003_2604	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BEST7003_2605	COG0572	uridine kinase
BEST7003_2609	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BEST7003_2610	COG3906	Belongs to the UPF0473 family
BEST7003_2611	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BEST7003_2612	COG4472	Bacterial protein of unknown function (DUF965)
BEST7003_2613	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BEST7003_2614	COG0628	permease
BEST7003_2615	COG1126	abc transporter atp-binding protein
BEST7003_2616	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_2617	COG0765	amino acid transport
BEST7003_2618	COG0765	amino acid transport
BEST7003_2621	COG3881	PFAM PRC-barrel domain
BEST7003_2622	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BEST7003_2623	COG0457	Tetratricopeptide repeat
BEST7003_2624	COG0482	sulfurtransferase activity
BEST7003_2625	COG1104	cysteine desulfurase activity
BEST7003_2626	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_2627	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BEST7003_2628	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BEST7003_2629	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BEST7003_2630	COG0124	histidyl-tRNA synthetase
BEST7003_2632	COG4991	sh3 domain protein
BEST7003_2632	COG3103	Sh3 type 3 domain protein
BEST7003_2632	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_2633	COG1490	D-aminoacyl-tRNA deacylase activity
BEST7003_2634	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BEST7003_2635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7003_2636	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BEST7003_2636	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BEST7003_2637	COG5416	Lipopolysaccharide assembly protein A domain
BEST7003_2638	COG0490	domain, Protein
BEST7003_2639	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7003_2639	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7003_2641	COG2244	polysaccharide biosynthetic process
BEST7003_2642	COG2323	membrane
BEST7003_2644	COG1862	Preprotein translocase
BEST7003_2645	COG0343	queuine tRNA-ribosyltransferase activity
BEST7003_2646	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BEST7003_2648	COG2255	four-way junction helicase activity
BEST7003_2649	COG0632	four-way junction helicase activity
BEST7003_2651	COG2814	Major facilitator Superfamily
BEST7003_2652	COG0673	inositol 2-dehydrogenase activity
BEST7003_2653	COG2112	serine threonine protein kinase
BEST7003_2657	COG1115	amino acid carrier protein
BEST7003_2658	COG0217	transcriptional regulatory protein
BEST7003_2660	COG1388	LysM domain
BEST7003_2661	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BEST7003_2662	COG0157	Belongs to the NadC ModD family
BEST7003_2663	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BEST7003_2664	COG1104	cysteine desulfurase activity
BEST7003_2665	COG1827	regulation of RNA biosynthetic process
BEST7003_2666	COG0077	Prephenate dehydratase
BEST7003_2667	COG4492	Belongs to the UPF0735 family
BEST7003_2668	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BEST7003_2669	COG3290	protein histidine kinase activity
BEST7003_2670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BEST7003_2671	COG2868	ribosomal protein
BEST7003_2672	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BEST7003_2673	COG1994	Peptidase M50
BEST7003_2674	COG0739	heme binding
BEST7003_2675	COG2894	cell division
BEST7003_2676	COG0850	regulation of cytokinetic process
BEST7003_2677	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BEST7003_2678	COG1792	Involved in formation and maintenance of cell shape
BEST7003_2679	COG1077	Cell shape determining protein MreB Mrl
BEST7003_2680	COG2003	Belongs to the UPF0758 family
BEST7003_2681	COG0424	maF-like protein
BEST7003_2683	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BEST7003_2684	COG0285	dihydrofolate synthase activity
BEST7003_2685	COG0525	valine-tRNA ligase activity
BEST7003_2687	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_2688	COG1388	LysM domain
BEST7003_2689	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BEST7003_2690	COG0113	porphobilinogen synthase activity
BEST7003_2691	COG1587	Uroporphyrinogen-III synthase
BEST7003_2692	COG0181	hydroxymethylbilane synthase activity
BEST7003_2693	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BEST7003_2694	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BEST7003_2696	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BEST7003_2697	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BEST7003_2698	COG1067	ATP-dependent peptidase activity
BEST7003_2698	COG0470	DNA polymerase III
BEST7003_2699	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BEST7003_2700	COG0544	peptidyl-prolyl cis-trans isomerase activity
BEST7003_2701	COG1477	protein flavinylation
BEST7003_2701	COG0457	Tetratricopeptide repeat
BEST7003_2702	COG0066	3-isopropylmalate dehydratase activity
BEST7003_2703	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BEST7003_2704	COG0473	3-isopropylmalate dehydrogenase activity
BEST7003_2705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7003_2706	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BEST7003_2707	COG0440	acetolactate synthase activity
BEST7003_2708	COG0028	Belongs to the TPP enzyme family
BEST7003_2710	COG0454	-acetyltransferase
BEST7003_2711	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BEST7003_2712	COG0622	Phosphoesterase
BEST7003_2713	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BEST7003_2714	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BEST7003_2715	COG5401	PFAM Sporulation and spore germination
BEST7003_2716	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BEST7003_2717	COG1846	Transcriptional regulator
BEST7003_2718	COG2197	response regulator
BEST7003_2719	COG0824	Thioesterase
BEST7003_2720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BEST7003_2721	COG1053	succinate dehydrogenase
BEST7003_2722	COG2009	succinate dehydrogenase
BEST7003_2723	COG1719	4-vinyl reductase, 4VR
BEST7003_2724	COG0527	aspartate kinase activity
BEST7003_2725	COG0322	excinuclease ABC activity
BEST7003_2726	COG3118	belongs to the thioredoxin family
BEST7003_2727	COG3534	alpha-L-arabinofuranosidase
BEST7003_2728	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BEST7003_2729	COG2086	electron transfer activity
BEST7003_2730	COG1024	Enoyl-CoA hydratase
BEST7003_2731	COG1309	transcriptional regulator
BEST7003_2732	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_2733	COG3766	membrane
BEST7003_2734	COG1193	negative regulation of DNA recombination
BEST7003_2735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BEST7003_2735	COG1796	DNA polymerase
BEST7003_2736	COG1286	toxin biosynthetic process
BEST7003_2737	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BEST7003_2738	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BEST7003_2739	COG0072	phenylalanine-tRNA ligase activity
BEST7003_2739	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_2740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BEST7003_2741	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7003_2743	COG3835	regulator
BEST7003_2744	COG0277	FAD linked oxidase domain protein
BEST7003_2745	COG0247	lactate metabolic process
BEST7003_2746	COG0346	lactoylglutathione lyase activity
BEST7003_2748	COG1966	Carbon starvation protein
BEST7003_2749	COG3534	alpha-L-arabinofuranosidase
BEST7003_2750	COG0395	ABC-type sugar transport system, permease component
BEST7003_2751	COG1175	transmembrane transport
BEST7003_2752	COG1653	transport
BEST7003_2753	COG0371	Dehydrogenase
BEST7003_2754	COG0647	UMP catabolic process
BEST7003_2755	COG0235	Class ii aldolase
BEST7003_2756	COG1069	ribulokinase activity
BEST7003_2757	COG2160	L-arabinose isomerase activity
BEST7003_2758	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_2759	COG1363	Peptidase, m42
BEST7003_2761	COG3326	Membrane
BEST7003_2762	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BEST7003_2763	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BEST7003_2764	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BEST7003_2766	COG1346	cytolysis
BEST7003_2767	COG1380	Effector of murein hydrolase LrgA
BEST7003_2768	COG3279	Response regulator of the LytR AlgR family
BEST7003_2769	COG3275	phosphorelay sensor kinase activity
BEST7003_2771	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BEST7003_2773	COG0398	Pfam SNARE associated Golgi protein
BEST7003_2774	COG1484	DNA-dependent DNA replication
BEST7003_2775	COG3611	Membrane attachment protein
BEST7003_2776	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BEST7003_2777	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BEST7003_2778	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7003_2779	COG1733	regulation of RNA biosynthetic process
BEST7003_2780	COG2814	Major facilitator Superfamily
BEST7003_2781	COG0656	L-ascorbic acid biosynthetic process
BEST7003_2782	COG0237	dephospho-CoA kinase activity
BEST7003_2783	COG1971	Probably functions as a manganese efflux pump
BEST7003_2784	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BEST7003_2785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7003_2785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7003_2786	COG5002	protein histidine kinase activity
BEST7003_2787	COG0745	RESPONSE REGULATOR receiver
BEST7003_2788	COG0039	L-malate dehydrogenase activity
BEST7003_2789	COG0538	isocitrate dehydrogenase activity
BEST7003_2790	COG0372	Belongs to the citrate synthase family
BEST7003_2791	COG2707	UPF0756 membrane protein
BEST7003_2792	COG0628	permease
BEST7003_2793	COG3030	protein affecting phage T7 exclusion by the F plasmid
BEST7003_2794	COG0469	pyruvate kinase activity
BEST7003_2795	COG0205	6-phosphofructokinase activity
BEST7003_2796	COG0825	malonyl-CoA metabolic process
BEST7003_2797	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BEST7003_2798	COG0281	malic enzyme
BEST7003_2799	COG0587	DNA-directed DNA polymerase activity
BEST7003_2803	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BEST7003_2805	COG4109	DRTGG domain
BEST7003_2806	COG0730	response to heat
BEST7003_2807	COG1473	amidohydrolase
BEST7003_2808	COG0196	riboflavin kinase activity
BEST7003_2809	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_2810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BEST7003_2811	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_2812	COG1126	abc transporter atp-binding protein
BEST7003_2813	COG0765	amino acid transport
BEST7003_2814	COG0765	amino acid transport
BEST7003_2815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_2816	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_2817	COG0454	-acetyltransferase
BEST7003_2818	COG0583	DNA-binding transcription factor activity
BEST7003_2819	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BEST7003_2820	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_2822	COG0165	Argininosuccinate lyase
BEST7003_2823	COG0137	argininosuccinate synthase activity
BEST7003_2824	COG0137	argininosuccinate synthase activity
BEST7003_2825	COG0521	Mo-molybdopterin cofactor biosynthetic process
BEST7003_2826	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BEST7003_2827	COG0827	DNA restriction-modification system
BEST7003_2828	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BEST7003_2829	COG3874	Sporulation protein YtfJ
BEST7003_2831	COG1714	RDD family
BEST7003_2832	COG0616	signal peptide processing
BEST7003_2833	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7003_2834	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BEST7003_2835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BEST7003_2837	COG0301	tRNA thio-modification
BEST7003_2838	COG1104	cysteine desulfurase activity
BEST7003_2839	COG1114	Component of the transport system for branched-chain amino acids
BEST7003_2840	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BEST7003_2841	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BEST7003_2842	COG1309	transcriptional regulator
BEST7003_2843	COG1956	GAF domain-containing protein
BEST7003_2844	COG2203	Gaf domain
BEST7003_2844	COG2199	diguanylate cyclase activity
BEST7003_2845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BEST7003_2847	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7003_2848	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BEST7003_2849	COG0454	-acetyltransferase
BEST7003_2850	COG0517	IMP dehydrogenase activity
BEST7003_2851	COG0123	including yeast histone deacetylase and acetoin utilization protein
BEST7003_2852	COG1360	Flagellar Motor Protein
BEST7003_2853	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BEST7003_2854	COG1609	Transcriptional regulator
BEST7003_2855	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BEST7003_2855	COG1605	Chorismate mutase
BEST7003_2856	COG3118	belongs to the thioredoxin family
BEST7003_2857	COG4980	gas vesicle protein
BEST7003_2858	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BEST7003_2859	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BEST7003_2860	COG1674	ftsk spoiiie
BEST7003_2861	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7003_2862	COG4848	Belongs to the UPF0354 family
BEST7003_2863	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_2865	COG1363	Peptidase, m42
BEST7003_2866	COG5584	Small secreted protein
BEST7003_2867	COG0281	malic enzyme
BEST7003_2868	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_2869	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BEST7003_2871	COG0510	thiamine kinase activity
BEST7003_2872	COG1523	belongs to the glycosyl hydrolase 13 family
BEST7003_2873	COG1597	lipid kinase activity
BEST7003_2875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BEST7003_2876	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7003_2877	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_2878	COG2252	PERMEase
BEST7003_2879	COG4473	ABC transporter
BEST7003_2880	COG1131	(ABC) transporter
BEST7003_2882	COG1349	DNA-binding transcription factor activity
BEST7003_2883	COG1187	pseudouridine synthase activity
BEST7003_2884	COG2244	polysaccharide biosynthetic process
BEST7003_2885	COG2081	HI0933 family
BEST7003_2886	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BEST7003_2888	COG5578	integral membrane protein
BEST7003_2889	COG0673	inositol 2-dehydrogenase activity
BEST7003_2890	COG1653	transport
BEST7003_2891	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BEST7003_2892	COG4209	transmembrane transport
BEST7003_2893	COG2207	Transcriptional regulator
BEST7003_2894	COG1653	transport
BEST7003_2895	COG0395	ABC-type sugar transport system, permease component
BEST7003_2896	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_2897	COG2124	cytochrome p450
BEST7003_2898	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BEST7003_2899	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BEST7003_2900	COG0156	8-amino-7-oxononanoate synthase activity
BEST7003_2901	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7003_2902	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BEST7003_2903	COG1073	alpha beta
BEST7003_2908	COG1486	melibiose metabolic process
BEST7003_2909	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7003_2910	COG0495	leucyl-tRNA aminoacylation
BEST7003_2912	COG2202	Pas domain
BEST7003_2912	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7003_2913	COG2814	Major facilitator Superfamily
BEST7003_2914	COG2433	Pfam Transposase IS66
BEST7003_2915	COG0577	efflux transmembrane transporter activity
BEST7003_2916	COG1136	(ABC) transporter
BEST7003_2917	COG2205	protein histidine kinase activity
BEST7003_2918	COG0745	RESPONSE REGULATOR receiver
BEST7003_2919	COG0577	efflux transmembrane transporter activity
BEST7003_2920	COG1136	(ABC) transporter
BEST7003_2923	COG1131	(ABC) transporter
BEST7003_2924	COG1725	Transcriptional regulator
BEST7003_2926	COG1242	4 iron, 4 sulfur cluster binding
BEST7003_2927	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BEST7003_2929	COG2267	carboxylic ester hydrolase activity
BEST7003_2930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BEST7003_2931	COG1113	amino acid transport
BEST7003_2932	COG0367	asparagine synthase
BEST7003_2933	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BEST7003_2934	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BEST7003_2936	COG1506	peptidase
BEST7003_2937	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7003_2938	COG1116	anion transmembrane transporter activity
BEST7003_2939	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7003_2940	COG0494	nUDIX hydrolase
BEST7003_2941	COG4824	toxin secretion phage lysis holin
BEST7003_2942	COG0783	Belongs to the Dps family
BEST7003_2945	COG1854	S-ribosylhomocysteine lyase activity
BEST7003_2946	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BEST7003_2947	COG0288	reversible hydration of carbon dioxide
BEST7003_2948	COG0254	rRNA binding
BEST7003_2949	COG1271	oxidase subunit
BEST7003_2950	COG1294	oxidase, subunit
BEST7003_2952	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7003_2953	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7003_2953	COG1321	iron dependent repressor
BEST7003_2954	COG1121	(ABC) transporter
BEST7003_2955	COG0803	Belongs to the bacterial solute-binding protein 9 family
BEST7003_2956	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7003_2957	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7003_2958	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BEST7003_2959	COG0596	Alpha beta hydrolase
BEST7003_2960	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BEST7003_2961	COG1169	isochorismate synthase
BEST7003_2962	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7003_2963	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7003_2964	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7003_2965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7003_2966	COG0438	transferase activity, transferring glycosyl groups
BEST7003_2968	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_2969	COG0438	transferase activity, transferring glycosyl groups
BEST7003_2970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_2971	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BEST7003_2972	COG0058	SHG alpha-glucan phosphorylase activity
BEST7003_2973	COG0297	glycogen (starch) synthase activity
BEST7003_2974	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7003_2975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7003_2976	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BEST7003_2977	COG3859	Proton-coupled thiamine transporter YuaJ
BEST7003_2978	COG1247	-acetyltransferase
BEST7003_2979	COG2268	Band 7 protein
BEST7003_2980	COG1585	Membrane protein implicated in regulation of membrane protease activity
BEST7003_2981	COG2318	DinB family
BEST7003_2983	COG1454	alcohol dehydrogenase
BEST7003_2985	COG1510	regulation of RNA biosynthetic process
BEST7003_2987	COG0569	domain protein
BEST7003_2988	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BEST7003_2989	COG4682	membrane
BEST7003_2990	COG1705	Flagellar rod assembly protein muramidase FlgJ
BEST7003_2991	COG0477	Major facilitator Superfamily
BEST7003_2992	COG5553	Cysteine dioxygenase type I
BEST7003_2993	COG1968	undecaprenyl-diphosphatase activity
BEST7003_2994	COG0628	permease
BEST7003_2995	COG0673	inositol 2-dehydrogenase activity
BEST7003_2996	COG4806	L-rhamnose isomerase
BEST7003_2997	COG3254	rhamnose metabolic process
BEST7003_2998	COG1070	Carbohydrate kinase
BEST7003_2999	COG1349	DNA-binding transcription factor activity
BEST7003_3000	COG3347	Dehydrogenase
BEST7003_3000	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3001	COG0840	transmembrane signaling receptor activity
BEST7003_3002	COG0840	transmembrane signaling receptor activity
BEST7003_3003	COG0840	transmembrane signaling receptor activity
BEST7003_3004	COG0840	transmembrane signaling receptor activity
BEST7003_3007	COG0432	Pfam Uncharacterised protein family UPF0047
BEST7003_3008	COG0366	Alpha amylase catalytic
BEST7003_3009	COG1253	flavin adenine dinucleotide binding
BEST7003_3010	COG2738	Putative neutral zinc metallopeptidase
BEST7003_3013	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BEST7003_3016	COG0166	Belongs to the GPI family
BEST7003_3017	COG1979	alcohol dehydrogenase
BEST7003_3018	COG1979	alcohol dehydrogenase
BEST7003_3019	COG2155	Conserved Protein
BEST7003_3020	COG1098	S1 RNA binding domain
BEST7003_3021	COG0436	Aminotransferase
BEST7003_3022	COG1522	sequence-specific DNA binding
BEST7003_3023	COG2267	carboxylic ester hydrolase activity
BEST7003_3025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BEST7003_3026	COG2205	protein histidine kinase activity
BEST7003_3028	COG5018	Exonuclease
BEST7003_3030	COG2814	Major facilitator Superfamily
BEST7003_3031	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_3032	COG3011	Protein conserved in bacteria
BEST7003_3034	COG3290	protein histidine kinase activity
BEST7003_3035	COG4565	transcriptional regulatory protein
BEST7003_3040	COG3493	citrate carrier protein
BEST7003_3042	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7003_3042	COG2111	Na H antiporter
BEST7003_3043	COG2111	Na H antiporter
BEST7003_3044	COG1006	Multisubunit Na H antiporter MnhC subunit
BEST7003_3045	COG0651	ATP synthesis coupled electron transport
BEST7003_3046	COG1863	multisubunit Na H antiporter MnhE subunit
BEST7003_3047	COG2212	antiporter activity
BEST7003_3048	COG1320	monovalent cation:proton antiporter activity
BEST7003_3049	COG2050	protein possibly involved in aromatic compounds catabolism
BEST7003_3050	COG2197	response regulator
BEST7003_3051	COG4585	Histidine kinase
BEST7003_3054	COG0142	geranyltranstransferase activity
BEST7003_3057	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BEST7003_3058	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BEST7003_3059	COG1335	isochorismatase
BEST7003_3060	COG5506	Protein of unknown function (DUF1694)
BEST7003_3063	COG0628	permease
BEST7003_3066	COG1418	mRNA catabolic process
BEST7003_3067	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3069	COG1511	domain protein
BEST7003_3070	COG0433	COG0433 Predicted ATPase
BEST7003_3070	COG1674	ftsk spoiiie
BEST7003_3071	COG4499	WXG100 protein secretion system (Wss), protein YukC
BEST7003_3072	COG5417	Belongs to the EsaB family
BEST7003_3073	COG4842	Belongs to the WXG100 family
BEST7003_3074	COG2508	Transcriptional regulator
BEST7003_3074	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BEST7003_3075	COG0686	Belongs to the AlaDH PNT family
BEST7003_3076	COG5634	Uncharacterized conserved protein (DUF2278)
BEST7003_3077	COG3251	PFAM MbtH domain protein
BEST7003_3078	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_3079	COG3433	isochorismatase activity
BEST7003_3079	COG1535	isochorismatase
BEST7003_3080	COG1021	2,3-dihydroxybenzoate-AMP ligase
BEST7003_3081	COG1169	isochorismate synthase
BEST7003_3082	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3083	COG2819	hydrolase of the alpha beta superfamily
BEST7003_3084	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BEST7003_3085	COG1268	BioY protein
BEST7003_3086	COG2056	Na+-H+ antiporter family
BEST7003_3087	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BEST7003_3088	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BEST7003_3089	COG3584	3D domain protein
BEST7003_3091	COG1252	NADH dehydrogenase
BEST7003_3092	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_3094	COG0516	GMP reductase activity
BEST7003_3095	COG2808	Putative FMN-binding domain
BEST7003_3096	COG0456	acetyltransferase
BEST7003_3097	COG0316	Belongs to the HesB IscA family
BEST7003_3098	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BEST7003_3099	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7003_3100	COG4844	belongs to the
BEST7003_3101	COG1252	NADH dehydrogenase
BEST7003_3102	COG4837	Protein of unknown function (DUF1462)
BEST7003_3103	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BEST7003_3104	COG0823	Involved in the tonB-independent uptake of proteins
BEST7003_3104	COG1506	peptidase
BEST7003_3104	COG4946	Tricorn protease homolog
BEST7003_3105	COG0083	homoserine kinase activity
BEST7003_3106	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BEST7003_3107	COG0460	homoserine dehydrogenase
BEST7003_3108	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7003_3109	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BEST7003_3110	COG0647	UMP catabolic process
BEST7003_3111	COG2445	Protein of unknown function DUF86
BEST7003_3112	COG4470	Protein conserved in bacteria
BEST7003_3114	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BEST7003_3115	COG0739	heme binding
BEST7003_3117	COG3377	Domain of unknown function (DUF1805)
BEST7003_3118	COG0737	Belongs to the 5'-nucleotidase family
BEST7003_3119	COG0730	response to heat
BEST7003_3120	COG1801	Protein of unknown function DUF72
BEST7003_3122	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BEST7003_3123	COG2508	Transcriptional regulator
BEST7003_3124	COG2233	PERMEase
BEST7003_3125	COG2233	PERMEase
BEST7003_3126	COG3195	allantoin biosynthetic process
BEST7003_3126	COG3648	Uricase
BEST7003_3127	COG2351	hydroxyisourate hydrolase activity
BEST7003_3129	COG2080	2 iron, 2 sulfur cluster binding
BEST7003_3130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BEST7003_3131	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BEST7003_3132	COG2068	MobA-Related Protein
BEST7003_3133	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BEST7003_3134	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BEST7003_3135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7003_3136	COG2356	endonuclease I
BEST7003_3137	COG3842	ATPase activity
BEST7003_3138	COG2188	Transcriptional regulator
BEST7003_3139	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_3140	COG0395	ABC-type sugar transport system, permease component
BEST7003_3141	COG1175	transmembrane transport
BEST7003_3142	COG1653	transport
BEST7003_3143	COG2222	sugar isomerase
BEST7003_3144	COG0322	excinuclease ABC activity
BEST7003_3145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7003_3148	COG0346	lactoylglutathione lyase activity
BEST7003_3149	COG0640	Transcriptional regulator
BEST7003_3150	COG0719	Fe-S assembly protein
BEST7003_3151	COG0822	iron-sulfur transferase activity
BEST7003_3152	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7003_3153	COG0719	Fe-S assembly protein
BEST7003_3154	COG0396	ATPase activity
BEST7003_3156	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BEST7003_3157	COG1464	Belongs to the NlpA lipoprotein family
BEST7003_3158	COG2011	ABC-type metal ion transport system permease component
BEST7003_3159	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BEST7003_3161	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7003_3162	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BEST7003_3164	COG0509	glycine decarboxylation via glycine cleavage system
BEST7003_3165	COG1393	Belongs to the ArsC family
BEST7003_3166	COG1960	acyl-CoA dehydrogenase activity
BEST7003_3167	COG0183	Belongs to the thiolase family
BEST7003_3168	COG1250	3-hydroxyacyl-CoA dehydrogenase
BEST7003_3168	COG1024	Enoyl-CoA hydratase
BEST7003_3170	COG0506	proline dehydrogenase activity
BEST7003_3172	COG5577	PFAM Coat F domain
BEST7003_3173	COG1846	Transcriptional regulator
BEST7003_3174	COG0477	Major facilitator Superfamily
BEST7003_3175	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_3176	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3177	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3178	COG0583	DNA-binding transcription factor activity
BEST7003_3180	COG1120	ATPase activity
BEST7003_3184	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3185	COG0783	Belongs to the Dps family
BEST7003_3186	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_3187	COG0745	RESPONSE REGULATOR receiver
BEST7003_3188	COG2205	protein histidine kinase activity
BEST7003_3188	COG2770	Histidine kinase
BEST7003_3190	COG1309	transcriptional regulator
BEST7003_3191	COG0114	fumarate hydratase activity
BEST7003_3193	COG0697	spore germination
BEST7003_3194	COG0814	amino acid
BEST7003_3196	COG2197	response regulator
BEST7003_3197	COG4585	Histidine kinase
BEST7003_3198	COG4758	membrane
BEST7003_3199	COG3595	metallopeptidase activity
BEST7003_3200	COG1842	Phage shock protein A
BEST7003_3201	COG4758	membrane
BEST7003_3202	COG2814	Major facilitator Superfamily
BEST7003_3203	COG2096	Adenosyltransferase
BEST7003_3204	COG1120	ATPase activity
BEST7003_3205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_3206	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_3207	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3208	COG3386	PFAM SMP-30 Gluconolaconase
BEST7003_3209	COG2205	protein histidine kinase activity
BEST7003_3210	COG0745	RESPONSE REGULATOR receiver
BEST7003_3212	COG1191	sigma factor activity
BEST7003_3214	COG2140	Oxalate decarboxylase
BEST7003_3216	COG0577	efflux transmembrane transporter activity
BEST7003_3217	COG1136	(ABC) transporter
BEST7003_3218	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7003_3219	COG1120	ATPase activity
BEST7003_3220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_3221	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7003_3222	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_3223	COG0531	amino acid
BEST7003_3225	COG1988	membrane-bound metal-dependent
BEST7003_3226	COG1368	sulfuric ester hydrolase activity
BEST7003_3227	COG1910	domain protein
BEST7003_3228	COG0725	ABC transporter, periplasmic molybdate-binding protein
BEST7003_3229	COG4149	molybdate abc transporter
BEST7003_3230	COG0656	L-ascorbic acid biosynthetic process
BEST7003_3232	COG0025	NhaP-type Na H and K H
BEST7003_3233	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7003_3234	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7003_3235	COG3973	AAA domain
BEST7003_3236	COG2860	membrane
BEST7003_3237	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BEST7003_3238	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BEST7003_3239	COG2217	Heavy metal translocating P-type atpase
BEST7003_3240	COG2217	Heavy metal translocating P-type atpase
BEST7003_3241	COG2608	mercury ion transmembrane transporter activity
BEST7003_3242	COG1937	Protein conserved in bacteria
BEST7003_3243	COG0673	inositol 2-dehydrogenase activity
BEST7003_3244	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BEST7003_3245	COG1289	transmembrane transporter activity
BEST7003_3247	COG2076	Multidrug Resistance protein
BEST7003_3248	COG1309	transcriptional regulator
BEST7003_3249	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BEST7003_3251	COG0557	exoribonuclease II activity
BEST7003_3252	COG1647	Serine aminopeptidase, S33
BEST7003_3253	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BEST7003_3254	COG0596	Alpha beta hydrolase
BEST7003_3255	COG1476	TRANSCRIPTIONal
BEST7003_3256	COG1396	sequence-specific DNA binding
BEST7003_3257	COG1396	sequence-specific DNA binding
BEST7003_3258	COG1733	regulation of RNA biosynthetic process
BEST7003_3259	COG0840	transmembrane signaling receptor activity
BEST7003_3260	COG1174	glycine betaine transport
BEST7003_3261	COG1732	Glycine betaine
BEST7003_3262	COG1174	glycine betaine transport
BEST7003_3263	COG1125	glycine betaine transport
BEST7003_3263	COG0517	IMP dehydrogenase activity
BEST7003_3264	COG1510	regulation of RNA biosynthetic process
BEST7003_3268	COG5658	integral membrane protein
BEST7003_3269	COG0640	Transcriptional regulator
BEST7003_3270	COG1174	glycine betaine transport
BEST7003_3271	COG1732	Glycine betaine
BEST7003_3272	COG1174	glycine betaine transport
BEST7003_3273	COG1125	glycine betaine transport
BEST7003_3273	COG0517	IMP dehydrogenase activity
BEST7003_3274	COG1510	regulation of RNA biosynthetic process
BEST7003_3275	COG2095	MarC family integral membrane protein
BEST7003_3277	COG3064	Membrane
BEST7003_3278	COG4640	response to antibiotic
BEST7003_3279	COG0456	acetyltransferase
BEST7003_3280	COG0148	phosphopyruvate hydratase activity
BEST7003_3281	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BEST7003_3282	COG0149	triose-phosphate isomerase activity
BEST7003_3283	COG0126	phosphoglycerate kinase activity
BEST7003_3284	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7003_3285	COG2390	Transcriptional regulator
BEST7003_3286	COG2814	Major facilitator Superfamily
BEST7003_3287	COG1609	Transcriptional regulator
BEST7003_3288	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_3289	COG0583	DNA-binding transcription factor activity
BEST7003_3290	COG0697	spore germination
BEST7003_3291	COG1113	amino acid transport
BEST7003_3292	COG3858	chitin binding
BEST7003_3293	COG1556	Lactate utilization protein
BEST7003_3294	COG1139	Iron-sulfur cluster binding protein
BEST7003_3295	COG0247	lactate metabolic process
BEST7003_3296	COG2197	response regulator
BEST7003_3297	COG4585	Histidine kinase
BEST7003_3298	COG0842	Transport permease protein
BEST7003_3299	COG1131	(ABC) transporter
BEST7003_3300	COG0596	Alpha beta hydrolase
BEST7003_3301	COG2208	phosphoserine phosphatase activity
BEST7003_3302	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BEST7003_3303	COG1874	Beta-galactosidase
BEST7003_3304	COG3833	ABC-type maltose transport systems, permease component
BEST7003_3305	COG1175	transmembrane transport
BEST7003_3306	COG2182	Extracellular solute-binding protein
BEST7003_3307	COG1609	Transcriptional regulator
BEST7003_3308	COG2186	Transcriptional regulator
BEST7003_3309	COG1620	l-lactate permease
BEST7003_3310	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BEST7003_3312	COG5039	Polysaccharide pyruvyl transferase
BEST7003_3313	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7003_3314	COG0110	maltose O-acetyltransferase activity
BEST7003_3315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BEST7003_3319	COG0438	transferase activity, transferring glycosyl groups
BEST7003_3320	COG1215	transferase activity, transferring glycosyl groups
BEST7003_3321	COG0438	transferase activity, transferring glycosyl groups
BEST7003_3322	COG1086	Polysaccharide biosynthesis protein
BEST7003_3323	COG0489	protein tyrosine kinase activity
BEST7003_3324	COG3944	biosynthesis protein
BEST7003_3325	COG1396	sequence-specific DNA binding
BEST7003_3326	COG2272	Belongs to the type-B carboxylesterase lipase family
BEST7003_3328	COG3479	Phenolic acid decarboxylase
BEST7003_3330	COG1794	racemase activity, acting on amino acids and derivatives
BEST7003_3331	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7003_3332	COG1621	beta-fructofuranosidase activity
BEST7003_3333	COG1621	beta-fructofuranosidase activity
BEST7003_3334	COG0531	amino acid
BEST7003_3335	COG1309	transcriptional regulator
BEST7003_3336	COG2076	Multidrug Resistance protein
BEST7003_3337	COG2076	Multidrug Resistance protein
BEST7003_3339	COG0277	FAD linked oxidase domain protein
BEST7003_3340	COG3621	Patatin-like phospholipase
BEST7003_3341	COG0740	serine-type endopeptidase activity
BEST7003_3342	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BEST7003_3343	COG0366	Alpha amylase catalytic
BEST7003_3344	COG1554	hydrolase, family 65, central catalytic
BEST7003_3345	COG5521	maltodextrose utilization protein MalA
BEST7003_3346	COG3833	ABC-type maltose transport systems, permease component
BEST7003_3347	COG1175	transmembrane transport
BEST7003_3348	COG2182	Extracellular solute-binding protein
BEST7003_3349	COG0366	Alpha amylase catalytic
BEST7003_3350	COG1609	Transcriptional regulator
BEST7003_3351	COG1611	Belongs to the LOG family
BEST7003_3352	COG1694	Mazg nucleotide pyrophosphohydrolase
BEST7003_3353	COG0659	secondary active sulfate transmembrane transporter activity
BEST7003_3354	COG0288	reversible hydration of carbon dioxide
BEST7003_3355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BEST7003_3356	COG0577	efflux transmembrane transporter activity
BEST7003_3357	COG1136	(ABC) transporter
BEST7003_3358	COG5002	protein histidine kinase activity
BEST7003_3359	COG0745	RESPONSE REGULATOR receiver
BEST7003_3361	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BEST7003_3362	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_3363	COG1481	regulation of sporulation
BEST7003_3364	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BEST7003_3365	COG1660	Displays ATPase and GTPase activities
BEST7003_3366	COG1051	belongs to the nudix hydrolase family
BEST7003_3367	COG0492	ferredoxin-NADP+ reductase activity
BEST7003_3368	COG0791	NLP P60 protein
BEST7003_3368	COG3883	PFAM NLP P60 protein
BEST7003_3369	COG0457	Tetratricopeptide repeat
BEST7003_3370	COG1132	(ABC) transporter
BEST7003_3374	COG0140	phosphoribosyl-ATP diphosphatase activity
BEST7003_3374	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BEST7003_3375	COG0107	imidazoleglycerol-phosphate synthase activity
BEST7003_3376	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BEST7003_3377	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BEST7003_3378	COG0131	Imidazoleglycerol-phosphate dehydratase
BEST7003_3379	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BEST7003_3380	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BEST7003_3381	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BEST7003_3382	COG4990	cell redox homeostasis
BEST7003_3383	COG5297	Belongs to the glycosyl hydrolase family 6
BEST7003_3384	COG0110	maltose O-acetyltransferase activity
BEST7003_3385	COG0546	phosphoglycolate phosphatase activity
BEST7003_3386	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BEST7003_3387	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BEST7003_3388	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BEST7003_3389	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BEST7003_3390	COG0363	glucosamine-6-phosphate deaminase activity
BEST7003_3392	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BEST7003_3393	COG1846	Transcriptional regulator
BEST7003_3394	COG2124	cytochrome p450
BEST7003_3396	COG1846	Transcriptional regulator
BEST7003_3397	COG2814	Major facilitator Superfamily
BEST7003_3398	COG1950	PFAM Membrane protein of
BEST7003_3399	COG1983	PspC domain protein
BEST7003_3400	COG3595	metallopeptidase activity
BEST7003_3403	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7003_3404	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BEST7003_3405	COG0556	nucleotide-excision repair
BEST7003_3406	COG4897	Protein conserved in bacteria
BEST7003_3407	COG3848	Pyruvate phosphate dikinase
BEST7003_3407	COG0574	Belongs to the PEP-utilizing enzyme family
BEST7003_3408	COG1309	transcriptional regulator
BEST7003_3409	COG2814	Major facilitator Superfamily
BEST7003_3410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_3412	COG0793	Belongs to the peptidase S41A family
BEST7003_3412	COG3409	Peptidoglycan-binding domain 1 protein
BEST7003_3413	COG2177	Part of the ABC transporter FtsEX involved in
BEST7003_3414	COG2884	Cell division ATP-binding protein ftsE
BEST7003_3415	COG2010	Cytochrome c
BEST7003_3416	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_3417	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BEST7003_3418	COG0653	protein targeting
BEST7003_3419	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BEST7003_3421	COG1516	flagellar protein fliS
BEST7003_3422	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BEST7003_3423	COG1334	flagellar protein FlaG
BEST7003_3424	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7003_3425	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BEST7003_3426	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BEST7003_3428	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7003_3429	COG1256	bacterial-type flagellum assembly
BEST7003_3429	COG4786	Flagellar basal body rod
BEST7003_3430	COG3418	PFAM FlgN family protein
BEST7003_3431	COG2747	anti-sigma28 factor FlgM
BEST7003_3433	COG1040	competence protein
BEST7003_3435	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BEST7003_3436	COG1307	EDD domain protein, DegV family
BEST7003_3437	COG2197	response regulator
BEST7003_3438	COG4585	Histidine kinase
BEST7003_3439	COG1739	Uncharacterized protein family UPF0029
BEST7003_3440	COG1316	TRANSCRIPTIONal
BEST7003_3441	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7003_3442	COG0438	transferase activity, transferring glycosyl groups
BEST7003_3443	COG1215	transferase activity, transferring glycosyl groups
BEST7003_3444	COG3206	protein involved in exopolysaccharide biosynthesis
BEST7003_3445	COG3307	-O-antigen
BEST7003_3446	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7003_3447	COG0297	glycogen (starch) synthase activity
BEST7003_3447	COG0438	transferase activity, transferring glycosyl groups
BEST7003_3448	COG2244	polysaccharide biosynthetic process
BEST7003_3450	COG2247	cell wall binding repeat
BEST7003_3450	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7003_3451	COG2385	sporulation resulting in formation of a cellular spore
BEST7003_3451	COG2247	cell wall binding repeat
BEST7003_3453	COG1316	TRANSCRIPTIONal
BEST7003_3454	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BEST7003_3455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7003_3456	COG1215	transferase activity, transferring glycosyl groups
BEST7003_3456	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_3457	COG0463	Glycosyl transferase, family 2
BEST7003_3459	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7003_3460	COG1134	teichoic acid transport
BEST7003_3461	COG1682	transport, permease protein
BEST7003_3462	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_3463	COG0438	transferase activity, transferring glycosyl groups
BEST7003_3464	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BEST7003_3465	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BEST7003_3466	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_3468	COG4193	domain, Protein
BEST7003_3469	COG1482	cell wall glycoprotein biosynthetic process
BEST7003_3470	COG0697	spore germination
BEST7003_3471	COG0814	amino acid
BEST7003_3473	COG2814	Major facilitator Superfamily
BEST7003_3474	COG1316	TRANSCRIPTIONal
BEST7003_3475	COG0561	phosphatase activity
BEST7003_3476	COG0791	NLP P60 protein
BEST7003_3478	COG2843	Capsule synthesis protein
BEST7003_3480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BEST7003_3481	COG1609	Transcriptional regulator
BEST7003_3482	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_3483	COG1869	D-ribose catabolic process
BEST7003_3484	COG1129	ABC transporter
BEST7003_3485	COG1172	Belongs to the binding-protein-dependent transport system permease family
BEST7003_3486	COG1879	ABC-type sugar transport system periplasmic component
BEST7003_3487	COG3103	Sh3 type 3 domain protein
BEST7003_3489	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7003_3490	COG3527	Alpha-acetolactate decarboxylase
BEST7003_3491	COG0028	Belongs to the TPP enzyme family
BEST7003_3492	COG0583	DNA-binding transcription factor activity
BEST7003_3493	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BEST7003_3496	COG5337	Spore coat protein CotH
BEST7003_3498	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7003_3500	COG0405	Gamma-glutamyltransferase
BEST7003_3501	COG1522	sequence-specific DNA binding
BEST7003_3502	COG2059	Chromate
BEST7003_3503	COG2059	Chromate
BEST7003_3505	COG0655	NAD(P)H dehydrogenase (quinone) activity
BEST7003_3506	COG0583	DNA-binding transcription factor activity
BEST7003_3507	COG1515	deoxyribonuclease V activity
BEST7003_3508	COG2849	repeat protein
BEST7003_3509	COG5444	nuclease activity
BEST7003_3512	COG3878	Protein conserved in bacteria
BEST7003_3513	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7003_3514	COG4464	protein tyrosine phosphatase activity
BEST7003_3515	COG0489	protein tyrosine kinase activity
BEST7003_3516	COG3944	biosynthesis protein
BEST7003_3518	COG4715	Zinc finger, swim domain protein
BEST7003_3519	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BEST7003_3520	COG0561	phosphatase activity
BEST7003_3521	COG1349	DNA-binding transcription factor activity
BEST7003_3522	COG0629	single-stranded DNA binding
BEST7003_3525	COG3764	Sortase (surface protein transpeptidase)
BEST7003_3527	COG0745	RESPONSE REGULATOR receiver
BEST7003_3527	COG2972	Histidine kinase
BEST7003_3528	COG1970	mechanosensitive ion channel activity
BEST7003_3529	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BEST7003_3530	COG0457	Tetratricopeptide repeat
BEST7003_3531	COG4786	Flagellar basal body rod
BEST7003_3532	COG4786	Flagellar basal body rod
BEST7003_3533	COG1077	Cell shape determining protein MreB Mrl
BEST7003_3534	COG1609	Transcriptional regulator
BEST7003_3535	COG1846	Transcriptional regulator
BEST7003_3536	COG2814	Major facilitator Superfamily
BEST7003_3537	COG3420	alginic acid biosynthetic process
BEST7003_3538	COG1953	Uracil, thiamine, allantoin
BEST7003_3539	COG0477	Major facilitator Superfamily
BEST7003_3540	COG1335	isochorismatase
BEST7003_3542	COG0004	ammonium transporteR
BEST7003_3543	COG0347	Belongs to the P(II) protein family
BEST7003_3544	COG0671	phosphoesterase, PA-phosphatase related
BEST7003_3546	COG0739	heme binding
BEST7003_3547	COG1247	-acetyltransferase
BEST7003_3550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7003_3551	COG0789	Transcriptional regulator
BEST7003_3553	COG2910	NAD(P)H-binding
BEST7003_3554	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_3555	COG0804	urea catabolic process
BEST7003_3556	COG0832	Belongs to the urease beta subunit family
BEST7003_3557	COG0831	urea catabolic process
BEST7003_3560	COG3237	CsbD-like
BEST7003_3561	COG1994	Peptidase M50
BEST7003_3562	COG0457	Tetratricopeptide repeat
BEST7003_3563	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BEST7003_3564	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BEST7003_3566	COG2304	oxidoreductase activity
BEST7003_3567	COG2304	oxidoreductase activity
BEST7003_3569	COG2385	sporulation resulting in formation of a cellular spore
BEST7003_3570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BEST7003_3572	COG4836	Membrane
BEST7003_3574	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BEST7003_3575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BEST7003_3576	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BEST7003_3577	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BEST7003_3578	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BEST7003_3579	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BEST7003_3580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BEST7003_3581	COG0356	it plays a direct role in the translocation of protons across the membrane
BEST7003_3583	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BEST7003_3584	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BEST7003_3585	COG4475	Protein of unknown function (DUF436)
BEST7003_3586	COG0698	ribose 5-phosphate isomerase
BEST7003_3587	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7003_3588	COG1971	Probably functions as a manganese efflux pump
BEST7003_3589	COG0009	L-threonylcarbamoyladenylate synthase
BEST7003_3590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BEST7003_3594	COG2890	protein-(glutamine-N5) methyltransferase activity
BEST7003_3595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BEST7003_3596	COG0346	lactoylglutathione lyase activity
BEST7003_3597	COG0789	Transcriptional regulator
BEST7003_3598	COG0679	Auxin Efflux Carrier
BEST7003_3599	COG0281	malic enzyme
BEST7003_3600	COG1435	thymidine kinase activity
BEST7003_3601	COG0254	rRNA binding
BEST7003_3602	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BEST7003_3603	COG1494	fructose-1,6-bisphosphatase
BEST7003_3604	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BEST7003_3605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BEST7003_3606	COG0191	fructose-bisphosphate aldolase activity
BEST7003_3607	COG2204	response regulator
BEST7003_3608	COG4821	SIS domain
BEST7003_3609	COG0504	CTP synthase activity
BEST7003_3610	COG3343	RNA polymerase activity
BEST7003_3611	COG1960	acyl-CoA dehydrogenase activity
BEST7003_3612	COG2181	nitrate reductase activity
BEST7003_3612	COG0247	lactate metabolic process
BEST7003_3613	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7003_3614	COG4294	response to UV
BEST7003_3616	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7003_3617	COG1132	(ABC) transporter
BEST7003_3618	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7003_3619	COG2181	nitrate reductase activity
BEST7003_3620	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BEST7003_3621	COG1140	nitrate reductase beta subunit
BEST7003_3622	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BEST7003_3623	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7003_3625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7003_3626	COG2223	nitrite transmembrane transporter activity
BEST7003_3627	COG0018	arginyl-trna synthetase
BEST7003_3628	COG4506	Protein conserved in bacteria
BEST7003_3630	COG0535	radical SAM domain protein
BEST7003_3632	COG1131	(ABC) transporter
BEST7003_3633	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7003_3634	COG0612	Peptidase, M16
BEST7003_3635	COG0612	Peptidase, M16
BEST7003_3637	COG3391	amine dehydrogenase activity
BEST7003_3638	COG3391	amine dehydrogenase activity
BEST7003_3639	COG0457	Tetratricopeptide repeat
BEST7003_3641	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BEST7003_3642	COG0010	Belongs to the arginase family
BEST7003_3643	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BEST7003_3644	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7003_3646	COG1994	Peptidase M50
BEST7003_3647	COG1942	4-Oxalocrotonate Tautomerase
BEST7003_3648	COG1846	Transcriptional regulator
BEST7003_3649	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BEST7003_3650	COG0477	Major facilitator Superfamily
BEST7003_3651	COG1959	2 iron, 2 sulfur cluster binding
BEST7003_3652	COG3465	dGTPase activity
BEST7003_3653	COG1078	dGTPase activity
BEST7003_3654	COG4844	belongs to the
BEST7003_3656	COG0697	spore germination
BEST7003_3657	COG0095	Lipoate-protein ligase
BEST7003_3658	COG0583	DNA-binding transcription factor activity
BEST7003_3659	COG0280	phosphate acetyltransferase
BEST7003_3661	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3662	COG0436	Aminotransferase
BEST7003_3663	COG2814	Major facilitator Superfamily
BEST7003_3664	COG0151	Belongs to the GarS family
BEST7003_3665	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3666	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_3667	COG0077	Prephenate dehydratase
BEST7003_3668	COG2814	Major facilitator Superfamily
BEST7003_3669	COG0833	amino acid
BEST7003_3670	COG4187	Peptidase family M20/M25/M40
BEST7003_3671	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_3672	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7003_3674	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BEST7003_3675	COG1091	dTDP-4-dehydrorhamnose reductase activity
BEST7003_3676	COG1088	dTDP-glucose 4,6-dehydratase activity
BEST7003_3677	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BEST7003_3678	COG3980	spore coat polysaccharide biosynthesis protein
BEST7003_3679	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BEST7003_3680	COG2089	acid synthase
BEST7003_3681	COG0456	acetyltransferase
BEST7003_3682	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7003_3683	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7003_3684	COG0463	Glycosyl transferase, family 2
BEST7003_3686	COG2363	Small membrane protein
BEST7003_3687	COG2233	PERMEase
BEST7003_3689	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_3690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BEST7003_3691	COG1216	Glycosyl transferase, family 2
BEST7003_3694	COG1695	Transcriptional regulator
BEST7003_3695	COG0351	phosphomethylpyrimidine kinase
BEST7003_3697	COG1621	beta-fructofuranosidase activity
BEST7003_3698	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_3698	COG1263	PTS System
BEST7003_3699	COG2116	formate transmembrane transporter activity
BEST7003_3700	COG3711	transcriptional antiterminator
BEST7003_3702	COG1404	Belongs to the peptidase S8 family
BEST7003_3703	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7003_3704	COG0778	Nitroreductase
BEST7003_3705	COG0772	Belongs to the SEDS family
BEST7003_3707	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BEST7003_3708	COG1845	cytochrome c oxidase, subunit III
BEST7003_3709	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7003_3710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BEST7003_3711	COG2261	transglycosylase associated protein
BEST7003_3712	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BEST7003_3713	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BEST7003_3714	COG2246	polysaccharide biosynthetic process
BEST7003_3715	COG1309	transcriptional regulator
BEST7003_3717	COG3162	membrane
BEST7003_3718	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7003_3719	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BEST7003_3720	COG2837	iron assimilation
BEST7003_3721	COG2822	iron ion transport
BEST7003_3722	COG0672	)-iron permease
BEST7003_3723	COG0352	thiamine-phosphate diphosphorylase activity
BEST7003_3724	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BEST7003_3725	COG0583	DNA-binding transcription factor activity
BEST7003_3726	COG1380	Effector of murein hydrolase LrgA
BEST7003_3727	COG1346	cytolysis
BEST7003_3728	COG2814	Major facilitator Superfamily
BEST7003_3729	COG4895	conserved protein (DUF2196)
BEST7003_3730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BEST7003_3731	COG0346	lactoylglutathione lyase activity
BEST7003_3733	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_3734	COG1404	Belongs to the peptidase S8 family
BEST7003_3735	COG1263	PTS System
BEST7003_3735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_3736	COG3711	transcriptional antiterminator
BEST7003_3737	COG1442	glycosyl transferase family 8
BEST7003_3738	COG5522	Integral membrane protein (intg_mem_TP0381)
BEST7003_3739	COG1846	Transcriptional regulator
BEST7003_3740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7003_3741	COG2234	aminopeptidase activity
BEST7003_3742	COG2357	RelA SpoT domain protein
BEST7003_3743	COG1575	Belongs to the MenA family. Type 1 subfamily
BEST7003_3744	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7003_3745	COG1696	Membrane protein involved in D-alanine export
BEST7003_3746	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7003_3747	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BEST7003_3748	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BEST7003_3749	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7003_3750	COG1486	melibiose metabolic process
BEST7003_3751	COG1447	Phosphotransferase system cellobiose-specific component IIA
BEST7003_3752	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_3753	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7003_3754	COG3711	transcriptional antiterminator
BEST7003_3754	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7003_3756	COG2094	Belongs to the DNA glycosylase MPG family
BEST7003_3757	COG0753	catalase activity
BEST7003_3758	COG2814	Major facilitator Superfamily
BEST7003_3759	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7003_3760	COG1131	(ABC) transporter
BEST7003_3764	COG1595	DNA-templated transcription, initiation
BEST7003_3765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BEST7003_3766	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BEST7003_3767	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BEST7003_3768	COG4988	ABC transporter
BEST7003_3769	COG1294	oxidase, subunit
BEST7003_3770	COG1271	oxidase subunit
BEST7003_3771	COG3493	citrate carrier protein
BEST7003_3772	COG0501	Belongs to the peptidase M48B family
BEST7003_3774	COG0726	polysaccharide deacetylase
BEST7003_3775	COG3842	ATPase activity
BEST7003_3776	COG2508	Transcriptional regulator
BEST7003_3777	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_3778	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7003_3780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BEST7003_3781	COG1881	PFAM PEBP family protein
BEST7003_3782	COG0583	DNA-binding transcription factor activity
BEST7003_3784	COG4585	Histidine kinase
BEST7003_3785	COG2197	response regulator
BEST7003_3786	COG2195	Cleaves the N-terminal amino acid of tripeptides
BEST7003_3788	COG4894	glucomannan catabolic process
BEST7003_3789	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7003_3790	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7003_3791	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3792	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BEST7003_3793	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BEST7003_3794	COG2610	gluconate transmembrane transporter activity
BEST7003_3795	COG0500	methyltransferase
BEST7003_3796	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7003_3800	COG0753	catalase activity
BEST7003_3800	COG0693	protein deglycase activity
BEST7003_3801	COG2851	Citrate transporter
BEST7003_3802	COG2273	Hydrolase Family 16
BEST7003_3803	COG3711	transcriptional antiterminator
BEST7003_3805	COG2270	Major facilitator Superfamily
BEST7003_3806	COG0513	Belongs to the DEAD box helicase family
BEST7003_3807	COG3401	FG-GAP repeat protein
BEST7003_3807	COG2755	lipolytic protein G-D-S-L family
BEST7003_3819	COG3209	COG3209 Rhs family protein
BEST7003_3820	COG0697	spore germination
BEST7003_3821	COG0589	response to stress
BEST7003_3822	COG2723	6-phospho-beta-galactosidase activity
BEST7003_3823	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7003_3823	COG2190	(PTS) system
BEST7003_3823	COG1263	PTS System
BEST7003_3826	COG5444	nuclease activity
BEST7003_3829	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7003_3832	COG2986	histidine ammonia-lyase
BEST7003_3833	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BEST7003_3834	COG1228	amidohydrolase
BEST7003_3835	COG0010	Belongs to the arginase family
BEST7003_3836	COG0833	amino acid
BEST7003_3837	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BEST7003_3838	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7003_3839	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BEST7003_3840	COG2390	Transcriptional regulator
BEST7003_3842	COG3192	ethanolamine utilization protein
BEST7003_3843	COG2079	MmgE PrpD family protein
BEST7003_3845	COG1126	abc transporter atp-binding protein
BEST7003_3846	COG0765	amino acid transport
BEST7003_3847	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7003_3851	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BEST7003_3852	COG0561	phosphatase activity
BEST7003_3858	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7003_3859	COG5294	Protein conserved in bacteria
BEST7003_3860	COG0577	efflux transmembrane transporter activity
BEST7003_3861	COG1136	(ABC) transporter
BEST7003_3862	COG2205	protein histidine kinase activity
BEST7003_3863	COG0745	RESPONSE REGULATOR receiver
BEST7003_3864	COG0191	fructose-bisphosphate aldolase activity
BEST7003_3865	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_3866	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_3867	COG0673	inositol 2-dehydrogenase activity
BEST7003_3868	COG2814	Major facilitator Superfamily
BEST7003_3869	COG1082	Xylose isomerase domain protein TIM barrel
BEST7003_3870	COG3962	Belongs to the TPP enzyme family
BEST7003_3871	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7003_3872	COG3718	enzyme involved in inositol metabolism
BEST7003_3873	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_3874	COG1349	DNA-binding transcription factor activity
BEST7003_3875	COG0667	Aldo Keto reductase
BEST7003_3878	COG2814	Major facilitator Superfamily
BEST7003_3879	COG0326	Molecular chaperone. Has ATPase activity
BEST7003_3881	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3882	COG1309	transcriptional regulator
BEST7003_3883	COG1012	belongs to the aldehyde dehydrogenase family
BEST7003_3884	COG0456	acetyltransferase
BEST7003_3885	COG2850	peptidyl-arginine hydroxylation
BEST7003_3886	COG2226	methyltransferase
BEST7003_3889	COG0367	asparagine synthase
BEST7003_3890	COG2814	Major facilitator Superfamily
BEST7003_3891	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BEST7003_3893	COG1714	RDD family
BEST7003_3894	COG2311	Membrane
BEST7003_3895	COG1917	Cupin 2, conserved barrel domain protein
BEST7003_3896	COG1309	transcriptional regulator
BEST7003_3897	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7003_3898	COG1846	Transcriptional regulator
BEST7003_3899	COG1380	Effector of murein hydrolase LrgA
BEST7003_3900	COG1346	cytolysis
BEST7003_3901	COG5039	Polysaccharide pyruvyl transferase
BEST7003_3902	COG1929	Belongs to the glycerate kinase type-1 family
BEST7003_3903	COG1802	Transcriptional regulator
BEST7003_3904	COG1070	Carbohydrate kinase
BEST7003_3905	COG2610	gluconate transmembrane transporter activity
BEST7003_3906	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BEST7003_3907	COG0450	alkyl hydroperoxide reductase
BEST7003_3908	COG3634	alkyl hydroperoxide reductase activity
BEST7003_3909	COG2723	6-phospho-beta-galactosidase activity
BEST7003_3910	COG2190	(PTS) system
BEST7003_3911	COG2188	Transcriptional regulator
BEST7003_3914	COG1131	(ABC) transporter
BEST7003_3915	COG1994	Peptidase M50
BEST7003_3916	COG0535	radical SAM domain protein
BEST7003_3918	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BEST7003_3919	COG5293	efflux transmembrane transporter activity
BEST7003_3921	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BEST7003_3922	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BEST7003_3925	COG1063	alcohol dehydrogenase
BEST7003_3929	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BEST7003_3930	COG0456	acetyltransferase
BEST7003_3931	COG0457	Tetratricopeptide repeat
BEST7003_3932	COG0010	Belongs to the arginase family
BEST7003_3933	COG0833	amino acid
BEST7003_3934	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BEST7003_3935	COG3829	transcription factor binding
BEST7003_3936	COG5002	protein histidine kinase activity
BEST7003_3937	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7003_3938	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BEST7003_3939	COG4853	Protein conserved in bacteria
BEST7003_3940	COG4863	YycH protein
BEST7003_3941	COG5002	protein histidine kinase activity
BEST7003_3942	COG0745	RESPONSE REGULATOR receiver
BEST7003_3944	COG0346	lactoylglutathione lyase activity
BEST7003_3945	COG0305	Participates in initiation and elongation during chromosome replication
BEST7003_3948	COG3093	addiction module antidote protein HigA
BEST7003_3949	COG2807	transmembrane transport
BEST7003_3950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BEST7003_3951	COG0359	binds to the 23S rRNA
BEST7003_3952	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BEST7003_3953	COG4241	membrane
BEST7003_3955	COG5577	PFAM Coat F domain
BEST7003_3956	COG1733	regulation of RNA biosynthetic process
BEST7003_3957	COG1227	inorganic diphosphatase activity
BEST7003_3960	COG2271	Major facilitator Superfamily
BEST7003_3967	COG1131	(ABC) transporter
BEST7003_3969	COG4319	ketosteroid isomerase
BEST7003_3970	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7003_3971	COG2814	Major facilitator Superfamily
BEST7003_3972	COG0583	DNA-binding transcription factor activity
BEST7003_3973	COG2153	protein acetylation
BEST7003_3975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7003_3976	COG1846	Transcriptional regulator
BEST7003_3977	COG2153	protein acetylation
BEST7003_3978	COG2364	Membrane
BEST7003_3979	COG0456	acetyltransferase
BEST7003_3980	COG2315	Protein conserved in bacteria
BEST7003_3981	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7003_3982	COG2814	Major facilitator Superfamily
BEST7003_3983	COG1331	Highly conserved protein containing a thioredoxin domain
BEST7003_3984	COG0789	Transcriptional regulator
BEST7003_3985	COG0697	spore germination
BEST7003_3986	COG1331	Highly conserved protein containing a thioredoxin domain
BEST7003_3987	COG1266	CAAX protease self-immunity
BEST7003_3988	COG2814	Major facilitator Superfamily
BEST7003_3988	COG0477	Major facilitator Superfamily
BEST7003_3989	COG0110	maltose O-acetyltransferase activity
BEST7003_3990	COG0346	lactoylglutathione lyase activity
BEST7003_3991	COG1609	Transcriptional regulator
BEST7003_3992	COG0708	Exodeoxyribonuclease III
BEST7003_3993	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BEST7003_3994	COG0629	single-stranded DNA binding
BEST7003_3995	COG0360	Binds together with S18 to 16S ribosomal RNA
BEST7003_3996	COG0012	GTP binding
BEST7003_3997	COG0243	molybdopterin cofactor binding
BEST7003_3998	COG4481	Protein conserved in bacteria
BEST7003_3999	COG3949	Membrane
BEST7003_4001	COG1475	DNA binding
BEST7003_4002	COG1192	Involved in chromosome partitioning
BEST7003_4004	COG1475	DNA binding
BEST7003_4005	COG0357	Ribosomal RNA small subunit methyltransferase G
BEST7003_4006	COG0445	tRNA wobble uridine modification
BEST7003_4007	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BEST7003_4008	COG1847	R3H domain protein
BEST7003_4009	COG0706	membrane insertase activity
BEST7003_4010	COG0594	ribonuclease P activity
BEST7003_4011	COG0230	Belongs to the bacterial ribosomal protein bL34 family