locus-tag	class	description
BEST7613_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BEST7613_0002	COG0592	DNA-directed DNA polymerase activity
BEST7613_0003	COG2501	S4 domain
BEST7613_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BEST7613_0006	COG0187	DNA topoisomerase II activity
BEST7613_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7613_0009	COG0517	IMP dehydrogenase activity
BEST7613_0009	COG0516	GMP reductase activity
BEST7613_0010	COG1686	Belongs to the peptidase S11 family
BEST7613_0011	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BEST7613_0012	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BEST7613_0013	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BEST7613_0014	COG1428	Deoxynucleoside kinase
BEST7613_0015	COG1428	Deoxynucleoside kinase
BEST7613_0016	COG1388	LysM domain
BEST7613_0016	COG3858	chitin binding
BEST7613_0017	COG1335	isochorismatase
BEST7613_0018	COG0590	tRNA wobble adenosine to inosine editing
BEST7613_0019	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BEST7613_0020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BEST7613_0021	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BEST7613_0025	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BEST7613_0026	COG3853	Toxic anion resistance protein (TelA)
BEST7613_0027	COG1982	Orn Lys Arg decarboxylase major
BEST7613_0028	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BEST7613_0029	COG3870	Protein conserved in bacteria
BEST7613_0030	COG1728	Protein conserved in bacteria
BEST7613_0031	COG0470	DNA polymerase III
BEST7613_0032	COG1774	PSP1 C-terminal conserved region
BEST7613_0033	COG4467	Involved in initiation control of chromosome replication
BEST7613_0034	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BEST7613_0035	COG2827	Endonuclease containing a URI domain
BEST7613_0036	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BEST7613_0037	COG2002	toxin-antitoxin pair type II binding
BEST7613_0038	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7613_0038	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7613_0039	COG0084	hydrolase, TatD family'
BEST7613_0040	COG3583	domain protein
BEST7613_0040	COG3584	3D domain protein
BEST7613_0041	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BEST7613_0042	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BEST7613_0044	COG4466	Protein conserved in bacteria
BEST7613_0046	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BEST7613_0047	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7613_0048	COG0251	oxidation-reduction process
BEST7613_0049	COG2088	sporulation resulting in formation of a cellular spore
BEST7613_0050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BEST7613_0051	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BEST7613_0052	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BEST7613_0053	COG0193	aminoacyl-tRNA hydrolase activity
BEST7613_0055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BEST7613_0056	COG2002	toxin-antitoxin pair type II binding
BEST7613_0057	COG2244	polysaccharide biosynthetic process
BEST7613_0058	COG3956	TIGRFAM MazG family protein
BEST7613_0059	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BEST7613_0062	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BEST7613_0063	COG1098	S1 RNA binding domain
BEST7613_0064	COG2208	phosphoserine phosphatase activity
BEST7613_0065	COG2304	oxidoreductase activity
BEST7613_0066	COG0515	serine threonine protein kinase
BEST7613_0067	COG0037	tRNA processing
BEST7613_0069	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7613_0070	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BEST7613_0071	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BEST7613_0072	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BEST7613_0073	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7613_0074	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7613_0075	COG0512	Glutamine amidotransferase of anthranilate synthase
BEST7613_0076	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7613_0077	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BEST7613_0078	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BEST7613_0079	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BEST7613_0080	COG1396	sequence-specific DNA binding
BEST7613_0081	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7613_0082	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BEST7613_0083	COG4463	regulation of RNA biosynthetic process
BEST7613_0084	COG3880	PFAM UvrB UvrC protein
BEST7613_0085	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BEST7613_0086	COG0542	response to heat
BEST7613_0087	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BEST7613_0088	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BEST7613_0089	COG4956	integral membrane protein (PIN domain superfamily)
BEST7613_0090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BEST7613_0091	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BEST7613_0092	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BEST7613_0093	COG1045	serine acetyltransferase
BEST7613_0094	COG0215	cysteine-tRNA ligase activity
BEST7613_0095	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BEST7613_0096	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7613_0097	COG3688	RNA-binding protein containing a PIN domain
BEST7613_0098	COG1595	DNA-templated transcription, initiation
BEST7613_0099	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BEST7613_0100	COG0250	Participates in transcription elongation, termination and antitermination
BEST7613_0101	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BEST7613_0102	COG0081	regulation of translation
BEST7613_0103	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BEST7613_0104	COG0222	ribosome binding
BEST7613_0105	COG2813	Specifically methylates the guanine in position
BEST7613_0106	COG0085	RNA polymerase activity
BEST7613_0107	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BEST7613_0108	COG1358	cellular component organization or biogenesis
BEST7613_0109	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BEST7613_0110	COG0049	tRNA binding
BEST7613_0111	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BEST7613_0112	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BEST7613_0113	COG0596	Alpha beta hydrolase
BEST7613_0114	COG0051	transcription antitermination factor activity, RNA binding
BEST7613_0115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BEST7613_0116	COG0088	Forms part of the polypeptide exit tunnel
BEST7613_0117	COG0089	rRNA binding
BEST7613_0118	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BEST7613_0119	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BEST7613_0120	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BEST7613_0121	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BEST7613_0122	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BEST7613_0123	COG0255	Belongs to the universal ribosomal protein uL29 family
BEST7613_0124	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BEST7613_0125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BEST7613_0127	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BEST7613_0129	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BEST7613_0130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BEST7613_0131	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BEST7613_0133	COG1841	ribosomal large subunit assembly
BEST7613_0134	COG0200	Binds to the 23S rRNA
BEST7613_0135	COG0201	protein transport
BEST7613_0136	COG0563	adenylate kinase activity
BEST7613_0137	COG0024	Methionine aminopeptidase
BEST7613_0138	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BEST7613_0139	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BEST7613_0140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BEST7613_0141	COG0202	RNA polymerase activity
BEST7613_0142	COG0203	ribosomal protein L17
BEST7613_0143	COG1122	ATPase activity
BEST7613_0144	COG1122	ATPase activity
BEST7613_0145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BEST7613_0146	COG0101	tRNA pseudouridine synthase activity
BEST7613_0147	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BEST7613_0148	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BEST7613_0149	COG2226	methyltransferase
BEST7613_0151	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7613_0152	COG0489	protein tyrosine kinase activity
BEST7613_0154	COG2194	sulfuric ester hydrolase activity
BEST7613_0155	COG0726	polysaccharide deacetylase
BEST7613_0156	COG0659	secondary active sulfate transmembrane transporter activity
BEST7613_0158	COG0385	Bile acid
BEST7613_0159	COG2819	hydrolase of the alpha beta superfamily
BEST7613_0160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_0161	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_0162	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_0163	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_0163	COG2207	Transcriptional regulator
BEST7613_0164	COG3876	Protein conserved in bacteria
BEST7613_0165	COG1472	Belongs to the glycosyl hydrolase 3 family
BEST7613_0166	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7613_0167	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_0167	COG1263	PTS System
BEST7613_0168	COG1737	Transcriptional regulator
BEST7613_0169	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BEST7613_0170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_0171	COG1683	Conserved Protein
BEST7613_0172	COG1595	DNA-templated transcription, initiation
BEST7613_0173	COG5662	AntiSigma factor
BEST7613_0174	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BEST7613_0175	COG4856	YbbR-like protein
BEST7613_0176	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BEST7613_0177	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BEST7613_0179	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BEST7613_0180	COG2169	Transcriptional regulator
BEST7613_0181	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BEST7613_0182	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7613_0183	COG3002	Belongs to the UPF0753 family
BEST7613_0184	COG0288	reversible hydration of carbon dioxide
BEST7613_0186	COG5609	conserved protein (DUF2294)
BEST7613_0188	COG0640	Transcriptional regulator
BEST7613_0189	COG2814	Major facilitator Superfamily
BEST7613_0190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BEST7613_0192	COG0535	radical SAM domain protein
BEST7613_0193	COG1266	CAAX protease self-immunity
BEST7613_0194	COG1131	(ABC) transporter
BEST7613_0196	COG1413	lyase activity
BEST7613_0197	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_0198	COG0596	Alpha beta hydrolase
BEST7613_0199	COG0745	RESPONSE REGULATOR receiver
BEST7613_0200	COG0642	Histidine kinase
BEST7613_0202	COG0515	serine threonine protein kinase
BEST7613_0205	COG1113	amino acid transport
BEST7613_0208	COG2602	Beta-lactamase
BEST7613_0209	COG2124	cytochrome p450
BEST7613_0211	COG0531	amino acid
BEST7613_0212	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7613_0213	COG2271	Major facilitator Superfamily
BEST7613_0215	COG0456	acetyltransferase
BEST7613_0215	COG1846	Transcriptional regulator
BEST7613_0216	COG2271	Major facilitator Superfamily
BEST7613_0219	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_0220	COG0697	spore germination
BEST7613_0221	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_0221	COG2207	Transcriptional regulator
BEST7613_0222	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BEST7613_0223	COG3591	Belongs to the peptidase S1B family
BEST7613_0225	COG0596	Alpha beta hydrolase
BEST7613_0226	COG1183	phosphatidylcholine synthase activity
BEST7613_0227	COG0586	Pfam SNARE associated Golgi protein
BEST7613_0228	COG0688	phosphatidylethanolamine metabolic process
BEST7613_0230	COG2312	Erythromycin esterase
BEST7613_0231	COG2207	Transcriptional regulator
BEST7613_0233	COG1301	dicarboxylic acid transport
BEST7613_0234	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_0234	COG2190	(PTS) system
BEST7613_0234	COG1263	PTS System
BEST7613_0235	COG0363	glucosamine-6-phosphate deaminase activity
BEST7613_0238	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7613_0239	COG0833	amino acid
BEST7613_0240	COG2040	homocysteine
BEST7613_0241	COG1115	amino acid carrier protein
BEST7613_0242	COG2066	Belongs to the glutaminase family
BEST7613_0243	COG4191	Histidine kinase
BEST7613_0244	COG0784	Response regulator, receiver
BEST7613_0245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BEST7613_0246	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_0247	COG2271	Major facilitator Superfamily
BEST7613_0248	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7613_0249	COG2186	Transcriptional regulator
BEST7613_0250	COG2721	sulfolactate sulfo-lyase activity
BEST7613_0251	COG3173	Aminoglycoside phosphotransferase
BEST7613_0253	COG0697	spore germination
BEST7613_0254	COG0745	RESPONSE REGULATOR receiver
BEST7613_0255	COG2205	protein histidine kinase activity
BEST7613_0256	COG1131	(ABC) transporter
BEST7613_0259	COG3773	Cell wall hydrolase
BEST7613_0260	COG2304	oxidoreductase activity
BEST7613_0261	COG3540	Alkaline phosphatase
BEST7613_0262	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7613_0263	COG0805	protein transport
BEST7613_0264	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BEST7613_0265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7613_0266	COG0477	Major facilitator Superfamily
BEST7613_0267	COG1309	transcriptional regulator
BEST7613_0268	COG0252	asparaginase activity
BEST7613_0269	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BEST7613_0270	COG1714	RDD family
BEST7613_0271	COG1405	negative regulation of cell septum assembly
BEST7613_0271	COG3012	SEC-C Motif Domain Protein
BEST7613_0272	COG3290	protein histidine kinase activity
BEST7613_0273	COG3279	Response regulator of the LytR AlgR family
BEST7613_0274	COG4555	ABC transporter
BEST7613_0275	COG1668	transmembrane transport
BEST7613_0276	COG0667	Aldo Keto reductase
BEST7613_0278	COG1595	DNA-templated transcription, initiation
BEST7613_0279	COG1595	DNA-templated transcription, initiation
BEST7613_0280	COG1876	peptidase activity
BEST7613_0281	COG0457	Tetratricopeptide repeat
BEST7613_0282	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_0283	COG0366	Alpha amylase catalytic
BEST7613_0284	COG0803	Belongs to the bacterial solute-binding protein 9 family
BEST7613_0285	COG1121	(ABC) transporter
BEST7613_0286	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7613_0287	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7613_0288	COG2310	stress, protein
BEST7613_0289	COG2310	stress, protein
BEST7613_0290	COG2310	stress, protein
BEST7613_0291	COG0861	Integral membrane protein TerC family
BEST7613_0293	COG3853	Toxic anion resistance protein (TelA)
BEST7613_0294	COG0477	Major facilitator Superfamily
BEST7613_0295	COG2814	Major facilitator Superfamily
BEST7613_0296	COG0640	Transcriptional regulator
BEST7613_0297	COG4175	Glycine betaine
BEST7613_0297	COG0517	IMP dehydrogenase activity
BEST7613_0298	COG4176	ABC-type proline glycine betaine transport system permease component
BEST7613_0299	COG2113	Glycine betaine
BEST7613_0300	COG1473	amidohydrolase
BEST7613_0301	COG1288	antiporter activity
BEST7613_0303	COG0366	Alpha amylase catalytic
BEST7613_0304	COG0039	L-malate dehydrogenase activity
BEST7613_0305	COG1620	l-lactate permease
BEST7613_0306	COG2814	Major facilitator Superfamily
BEST7613_0307	COG1846	Transcriptional regulator
BEST7613_0308	COG1280	lysine exporter protein (LysE YggA)
BEST7613_0309	COG3403	YqcI/YcgG family
BEST7613_0310	COG1113	amino acid transport
BEST7613_0311	COG3665	Urea carboxylase-associated protein
BEST7613_0312	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BEST7613_0313	COG1660	Displays ATPase and GTPase activities
BEST7613_0314	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BEST7613_0315	COG2226	methyltransferase
BEST7613_0316	COG0583	DNA-binding transcription factor activity
BEST7613_0317	COG3458	cephalosporin-C deacetylase activity
BEST7613_0318	COG3541	Predicted nucleotidyltransferase
BEST7613_0319	COG0506	proline dehydrogenase activity
BEST7613_0320	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_0321	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7613_0322	COG2508	Transcriptional regulator
BEST7613_0323	COG3689	TIGRFAM TIGR03943 family protein
BEST7613_0324	COG0701	Predicted permease
BEST7613_0325	COG2267	carboxylic ester hydrolase activity
BEST7613_0326	COG0492	ferredoxin-NADP+ reductase activity
BEST7613_0327	COG1587	Uroporphyrinogen-III synthase
BEST7613_0327	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BEST7613_0328	COG2146	nitrite reductase [NAD(P)H] activity
BEST7613_0329	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7613_0330	COG0243	molybdopterin cofactor binding
BEST7613_0331	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7613_0332	COG2223	nitrite transmembrane transporter activity
BEST7613_0333	COG1469	GTP cyclohydrolase I activity
BEST7613_0334	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7613_0335	COG0523	cobalamin synthesis protein
BEST7613_0336	COG0765	amino acid transport
BEST7613_0337	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_0339	COG1714	RDD family
BEST7613_0341	COG2723	6-phospho-beta-galactosidase activity
BEST7613_0343	COG3209	COG3209 Rhs family protein
BEST7613_0344	COG0840	transmembrane signaling receptor activity
BEST7613_0344	COG3290	protein histidine kinase activity
BEST7613_0345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BEST7613_0346	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BEST7613_0347	COG1733	regulation of RNA biosynthetic process
BEST7613_0348	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_0349	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_0350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_0351	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BEST7613_0352	COG2814	Major facilitator Superfamily
BEST7613_0354	COG0697	spore germination
BEST7613_0355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7613_0358	COG2364	Membrane
BEST7613_0359	COG1126	abc transporter atp-binding protein
BEST7613_0360	COG0765	amino acid transport
BEST7613_0361	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_0362	COG0583	DNA-binding transcription factor activity
BEST7613_0363	COG0163	prenyltransferase activity
BEST7613_0364	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BEST7613_0367	COG0596	Alpha beta hydrolase
BEST7613_0368	COG3104	oligopeptide transport
BEST7613_0369	COG5434	Belongs to the glycosyl hydrolase 28 family
BEST7613_0371	COG0697	spore germination
BEST7613_0373	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BEST7613_0374	COG1136	(ABC) transporter
BEST7613_0375	COG0577	efflux transmembrane transporter activity
BEST7613_0376	COG0745	RESPONSE REGULATOR receiver
BEST7613_0377	COG5002	protein histidine kinase activity
BEST7613_0377	COG3850	Histidine kinase
BEST7613_0378	COG0457	Tetratricopeptide repeat
BEST7613_0380	COG0527	aspartate kinase activity
BEST7613_0381	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_0382	COG4605	iron ion homeostasis
BEST7613_0383	COG4604	ABC transporter, ATP-binding protein
BEST7613_0384	COG4607	ABC-type enterochelin transport system periplasmic component
BEST7613_0385	COG2814	Major facilitator Superfamily
BEST7613_0386	COG1309	transcriptional regulator
BEST7613_0387	COG0778	Nitroreductase
BEST7613_0388	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BEST7613_0389	COG0640	Transcriptional regulator
BEST7613_0390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7613_0391	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BEST7613_0392	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_0393	COG4975	Glucose uptake
BEST7613_0394	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_0395	COG4549	nuclear export factor GLE1
BEST7613_0396	COG1276	copper resistance
BEST7613_0396	COG2372	response to copper ion
BEST7613_0397	COG1349	DNA-binding transcription factor activity
BEST7613_0399	COG2213	PTS system mannitol-specific
BEST7613_0400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_0401	COG0246	Mannitol dehydrogenase
BEST7613_0402	COG0473	3-isopropylmalate dehydrogenase activity
BEST7613_0404	COG0681	Belongs to the peptidase S26 family
BEST7613_0405	COG0412	Dienelactone hydrolase
BEST7613_0406	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BEST7613_0408	COG0561	phosphatase activity
BEST7613_0409	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BEST7613_0410	COG1914	H( )-stimulated, divalent metal cation uptake system
BEST7613_0411	COG4336	lyase activity
BEST7613_0412	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BEST7613_0413	COG1984	allophanate hydrolase subunit 2
BEST7613_0414	COG1414	Transcriptional regulator
BEST7613_0415	COG2755	lipolytic protein G-D-S-L family
BEST7613_0417	COG2329	Antibiotic biosynthesis monooxygenase
BEST7613_0418	COG0768	penicillin binding
BEST7613_0419	COG4989	oxidoreductase activity
BEST7613_0420	COG3711	transcriptional antiterminator
BEST7613_0421	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_0422	COG2226	methyltransferase
BEST7613_0423	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_0424	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_0425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_0426	COG3871	stress protein (general stress protein 26)
BEST7613_0428	COG2814	Major facilitator Superfamily
BEST7613_0429	COG1522	sequence-specific DNA binding
BEST7613_0430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BEST7613_0430	COG0551	DNA topoisomerase type I activity
BEST7613_0431	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BEST7613_0432	COG3706	GGDEF domain
BEST7613_0433	COG5298	Protein conserved in bacteria
BEST7613_0434	COG1215	transferase activity, transferring glycosyl groups
BEST7613_0436	COG0531	amino acid
BEST7613_0437	COG0494	nUDIX hydrolase
BEST7613_0438	COG0028	Belongs to the TPP enzyme family
BEST7613_0441	COG1914	H( )-stimulated, divalent metal cation uptake system
BEST7613_0442	COG2261	transglycosylase associated protein
BEST7613_0443	COG4876	unkown
BEST7613_0444	COG2217	Heavy metal translocating P-type atpase
BEST7613_0445	COG3729	General stress protein
BEST7613_0446	COG0662	Cupin 2, conserved barrel domain protein
BEST7613_0447	COG2329	Antibiotic biosynthesis monooxygenase
BEST7613_0448	COG3546	catalase activity
BEST7613_0449	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BEST7613_0450	COG3290	protein histidine kinase activity
BEST7613_0451	COG4565	transcriptional regulatory protein
BEST7613_0452	COG1301	dicarboxylic acid transport
BEST7613_0453	COG0628	permease
BEST7613_0454	COG1131	(ABC) transporter
BEST7613_0455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7613_0457	COG1960	acyl-CoA dehydrogenase activity
BEST7613_0460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7613_0461	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_0462	COG1181	Belongs to the D-alanine--D-alanine ligase family
BEST7613_0463	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BEST7613_0464	COG0513	Belongs to the DEAD box helicase family
BEST7613_0465	COG3402	PFAM membrane-flanked domain
BEST7613_0466	COG3428	Bacterial PH domain
BEST7613_0467	COG0705	Rhomboid family
BEST7613_0468	COG0736	holo-[acyl-carrier-protein] synthase activity
BEST7613_0469	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BEST7613_0470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BEST7613_0471	COG0864	Transcriptional regulator
BEST7613_0472	COG2337	Toxic component of a toxin-antitoxin (TA) module
BEST7613_0473	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_0474	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_0475	COG2172	sigma factor antagonist activity
BEST7613_0476	COG2208	phosphoserine phosphatase activity
BEST7613_0477	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_0478	COG2172	sigma factor antagonist activity
BEST7613_0479	COG1191	sigma factor activity
BEST7613_0480	COG2208	phosphoserine phosphatase activity
BEST7613_0483	COG1673	EVE domain
BEST7613_0484	COG1846	Transcriptional regulator
BEST7613_0485	COG2183	response to ionizing radiation
BEST7613_0486	COG3091	SprT-like family
BEST7613_0487	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7613_0488	COG1522	sequence-specific DNA binding
BEST7613_0489	COG1522	sequence-specific DNA binding
BEST7613_0490	COG1335	isochorismatase
BEST7613_0491	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BEST7613_0492	COG2814	Major facilitator Superfamily
BEST7613_0496	COG0693	protein deglycase activity
BEST7613_0497	COG1278	Cold shock
BEST7613_0498	COG1329	Transcriptional regulator
BEST7613_0499	COG0697	spore germination
BEST7613_0500	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_0500	COG2207	Transcriptional regulator
BEST7613_0501	COG0697	spore germination
BEST7613_0502	COG2207	Transcriptional regulator
BEST7613_0502	COG3708	Transcriptional regulator
BEST7613_0503	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7613_0504	COG0477	Major facilitator Superfamily
BEST7613_0506	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BEST7613_0508	COG0697	spore germination
BEST7613_0509	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7613_0510	COG2030	dehydratase
BEST7613_0511	COG3545	Serine hydrolase
BEST7613_0512	COG1733	regulation of RNA biosynthetic process
BEST7613_0513	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7613_0514	COG1733	regulation of RNA biosynthetic process
BEST7613_0515	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7613_0516	COG2814	Major facilitator Superfamily
BEST7613_0517	COG1309	transcriptional regulator
BEST7613_0519	COG0640	Transcriptional regulator
BEST7613_0520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BEST7613_0521	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_0522	COG0697	spore germination
BEST7613_0523	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7613_0524	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7613_0525	COG0640	Transcriptional regulator
BEST7613_0526	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BEST7613_0528	COG4585	Histidine kinase
BEST7613_0529	COG2197	response regulator
BEST7613_0530	COG2409	Drug exporters of the RND superfamily
BEST7613_0531	COG0596	Alpha beta hydrolase
BEST7613_0532	COG1811	Na channel or pump
BEST7613_0533	COG4978	Transcriptional regulator
BEST7613_0533	COG0789	Transcriptional regulator
BEST7613_0534	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7613_0535	COG0778	Nitroreductase
BEST7613_0536	COG0346	lactoylglutathione lyase activity
BEST7613_0537	COG2259	Doxx family
BEST7613_0538	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_0541	COG2323	membrane
BEST7613_0542	COG2323	membrane
BEST7613_0543	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7613_0546	COG1309	transcriptional regulator
BEST7613_0548	COG0456	acetyltransferase
BEST7613_0550	COG1113	amino acid transport
BEST7613_0551	COG2318	DinB family
BEST7613_0552	COG1846	Transcriptional regulator
BEST7613_0553	COG2409	Drug exporters of the RND superfamily
BEST7613_0553	COG1033	growth of symbiont in host cell
BEST7613_0554	COG0778	Nitroreductase
BEST7613_0555	COG1846	Transcriptional regulator
BEST7613_0556	COG2814	Major facilitator Superfamily
BEST7613_0557	COG0730	response to heat
BEST7613_0558	COG1802	Transcriptional regulator
BEST7613_0559	COG3858	chitin binding
BEST7613_0559	COG1388	LysM domain
BEST7613_0560	COG1819	glycosyl
BEST7613_0562	COG1785	Belongs to the alkaline phosphatase family
BEST7613_0563	COG5646	InterPro IPR014922
BEST7613_0565	COG0454	-acetyltransferase
BEST7613_0566	COG1078	dGTPase activity
BEST7613_0567	COG1388	LysM domain
BEST7613_0568	COG2814	Major facilitator Superfamily
BEST7613_0569	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7613_0570	COG1447	Phosphotransferase system cellobiose-specific component IIA
BEST7613_0571	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7613_0572	COG2723	6-phospho-beta-galactosidase activity
BEST7613_0573	COG2188	Transcriptional regulator
BEST7613_0574	COG1940	carbohydrate kinase activity
BEST7613_0575	COG1482	cell wall glycoprotein biosynthetic process
BEST7613_0576	COG4124	Belongs to the glycosyl hydrolase 26 family
BEST7613_0580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BEST7613_0581	COG0802	atpase or kinase
BEST7613_0582	COG1214	PFAM Peptidase M22, glycoprotease
BEST7613_0583	COG0456	acetyltransferase
BEST7613_0584	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BEST7613_0585	COG0488	(ABC) transporter
BEST7613_0586	COG0315	cyclic pyranopterin monophosphate synthase activity
BEST7613_0587	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BEST7613_0588	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7613_0589	COG0805	protein transport
BEST7613_0591	COG1266	CAAX protease self-immunity
BEST7613_0592	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BEST7613_0595	COG0457	Tetratricopeptide repeat
BEST7613_0596	COG1063	alcohol dehydrogenase
BEST7613_0597	COG2211	Major facilitator Superfamily
BEST7613_0598	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7613_0600	COG1842	Phage shock protein A
BEST7613_0601	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BEST7613_0602	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BEST7613_0603	COG4260	virion core protein, lumpy skin disease virus
BEST7613_0604	COG2755	lipolytic protein G-D-S-L family
BEST7613_0604	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BEST7613_0606	COG1595	DNA-templated transcription, initiation
BEST7613_0607	COG1063	alcohol dehydrogenase
BEST7613_0608	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BEST7613_0609	COG0823	Involved in the tonB-independent uptake of proteins
BEST7613_0612	COG2132	Multicopper oxidase
BEST7613_0613	COG1113	amino acid transport
BEST7613_0614	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7613_0615	COG0714	Associated with various cellular activities
BEST7613_0616	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BEST7613_0617	COG1305	Transglutaminase-like
BEST7613_0619	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7613_0623	COG2211	Major facilitator Superfamily
BEST7613_0626	COG2252	PERMEase
BEST7613_0627	COG3064	Membrane
BEST7613_0631	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BEST7613_0632	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BEST7613_0633	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BEST7613_0634	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BEST7613_0635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BEST7613_0638	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BEST7613_0639	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BEST7613_0640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BEST7613_0641	COG0138	bifunctional purine biosynthesis protein purh
BEST7613_0642	COG0151	Belongs to the GarS family
BEST7613_0643	COG1522	sequence-specific DNA binding
BEST7613_0644	COG0531	amino acid
BEST7613_0646	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BEST7613_0647	COG1470	cell adhesion involved in biofilm formation
BEST7613_0648	COG4496	protein, YerC YecD
BEST7613_0649	COG0069	glutamate synthase activity
BEST7613_0650	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BEST7613_0651	COG0210	DNA helicase
BEST7613_0652	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BEST7613_0653	COG4851	CamS sex pheromone cAM373 precursor
BEST7613_0654	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7613_0655	COG1285	pathogenesis
BEST7613_0656	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7613_0657	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7613_0658	COG0154	amidase activity
BEST7613_0659	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7613_0660	COG1309	transcriptional regulator
BEST7613_0661	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BEST7613_0662	COG1597	lipid kinase activity
BEST7613_0663	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BEST7613_0664	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7613_0665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7613_0666	COG1002	Type II restriction enzyme, methylase subunits
BEST7613_0667	COG1061	Type III restriction enzyme res subunit
BEST7613_0668	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7613_0672	COG5444	nuclease activity
BEST7613_0673	COG3391	amine dehydrogenase activity
BEST7613_0674	COG0457	Tetratricopeptide repeat
BEST7613_0676	COG0217	transcriptional regulatory protein
BEST7613_0678	COG1309	transcriptional regulator
BEST7613_0679	COG3631	Ketosteroid isomerase-related protein
BEST7613_0680	COG0702	epimerase
BEST7613_0683	COG3546	catalase activity
BEST7613_0684	COG0454	-acetyltransferase
BEST7613_0686	COG5578	integral membrane protein
BEST7613_0687	COG2972	Histidine kinase
BEST7613_0688	COG2207	Transcriptional regulator
BEST7613_0688	COG4753	response regulator
BEST7613_0689	COG1653	transport
BEST7613_0690	COG1175	transmembrane transport
BEST7613_0691	COG0395	ABC-type sugar transport system, permease component
BEST7613_0692	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BEST7613_0693	COG2207	Transcriptional regulator
BEST7613_0694	COG2755	lipolytic protein G-D-S-L family
BEST7613_0696	COG5578	integral membrane protein
BEST7613_0697	COG3401	FG-GAP repeat protein
BEST7613_0698	COG3401	FG-GAP repeat protein
BEST7613_0699	COG2755	lipolytic protein G-D-S-L family
BEST7613_0700	COG1874	Beta-galactosidase
BEST7613_0702	COG1653	transport
BEST7613_0703	COG4209	transmembrane transport
BEST7613_0704	COG0395	ABC-type sugar transport system, permease component
BEST7613_0705	COG1486	melibiose metabolic process
BEST7613_0706	COG2323	membrane
BEST7613_0707	COG2329	Antibiotic biosynthesis monooxygenase
BEST7613_0708	COG0346	lactoylglutathione lyase activity
BEST7613_0710	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_0712	COG5583	Uncharacterized small protein (DUF2292)
BEST7613_0713	COG0670	Belongs to the BI1 family
BEST7613_0714	COG0697	spore germination
BEST7613_0715	COG1846	Transcriptional regulator
BEST7613_0716	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7613_0718	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7613_0718	COG2124	cytochrome p450
BEST7613_0719	COG1368	sulfuric ester hydrolase activity
BEST7613_0720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BEST7613_0721	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7613_0722	COG1442	glycosyl transferase family 8
BEST7613_0723	COG1216	Glycosyl transferase, family 2
BEST7613_0724	COG1442	glycosyl transferase family 8
BEST7613_0725	COG2223	nitrite transmembrane transporter activity
BEST7613_0726	COG1011	Hydrolase
BEST7613_0727	COG0531	amino acid
BEST7613_0728	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_0729	COG0840	transmembrane signaling receptor activity
BEST7613_0730	COG0488	(ABC) transporter
BEST7613_0732	COG0789	Transcriptional regulator
BEST7613_0733	COG2814	Major facilitator Superfamily
BEST7613_0735	COG0488	(ABC) transporter
BEST7613_0736	COG0513	Belongs to the DEAD box helicase family
BEST7613_0737	COG0456	acetyltransferase
BEST7613_0738	COG2130	NADP-dependent
BEST7613_0740	COG2211	Major facilitator Superfamily
BEST7613_0741	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BEST7613_0742	COG1120	ATPase activity
BEST7613_0743	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_0744	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_0745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BEST7613_0748	COG3866	Pectate lyase
BEST7613_0749	COG0471	metal ion transport
BEST7613_0750	COG3290	protein histidine kinase activity
BEST7613_0751	COG4565	transcriptional regulatory protein
BEST7613_0752	COG3181	Tripartite tricarboxylate transporter family receptor
BEST7613_0753	COG2851	Citrate transporter
BEST7613_0754	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_0755	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BEST7613_0756	COG1254	Belongs to the acylphosphatase family
BEST7613_0757	COG2258	MOSC domain
BEST7613_0761	COG0024	Methionine aminopeptidase
BEST7613_0762	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_0762	COG1263	PTS System
BEST7613_0763	COG1368	sulfuric ester hydrolase activity
BEST7613_0765	COG1115	amino acid carrier protein
BEST7613_0766	COG0531	amino acid
BEST7613_0769	COG0697	spore germination
BEST7613_0770	COG1263	PTS System
BEST7613_0770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_0771	COG0366	Alpha amylase catalytic
BEST7613_0772	COG2188	Transcriptional regulator
BEST7613_0773	COG0778	Nitroreductase
BEST7613_0774	COG0737	Belongs to the 5'-nucleotidase family
BEST7613_0775	COG0693	protein deglycase activity
BEST7613_0776	COG2814	Major facilitator Superfamily
BEST7613_0777	COG4840	Belongs to the UPF0435 family
BEST7613_0778	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7613_0779	COG4980	gas vesicle protein
BEST7613_0780	COG1295	ribonuclease BN
BEST7613_0781	COG0477	Major facilitator Superfamily
BEST7613_0782	COG0387	Pfam Sodium calcium exchanger
BEST7613_0784	COG0668	transmembrane transport
BEST7613_0785	COG0535	radical SAM domain protein
BEST7613_0787	COG0726	polysaccharide deacetylase
BEST7613_0788	COG2084	Dehydrogenase
BEST7613_0789	COG0598	Magnesium transport protein CorA
BEST7613_0790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BEST7613_0791	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BEST7613_0793	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7613_0794	COG4637	Psort location Cytoplasmic, score
BEST7613_0796	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7613_0797	COG0022	dehydrogenase e1 component
BEST7613_0798	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7613_0799	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7613_0800	COG3284	Transcriptional regulator
BEST7613_0802	COG1742	UPF0060 membrane protein
BEST7613_0807	COG4842	Belongs to the WXG100 family
BEST7613_0808	COG1486	melibiose metabolic process
BEST7613_0809	COG1737	Transcriptional regulator
BEST7613_0810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_0810	COG1263	PTS System
BEST7613_0811	COG1132	(ABC) transporter
BEST7613_0812	COG1132	(ABC) transporter
BEST7613_0813	COG2259	Doxx family
BEST7613_0814	COG2514	catechol 2,3-dioxygenase activity
BEST7613_0815	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_0815	COG4977	sequence-specific DNA binding
BEST7613_0816	COG2814	Major facilitator Superfamily
BEST7613_0817	COG1082	Xylose isomerase domain protein TIM barrel
BEST7613_0818	COG0673	inositol 2-dehydrogenase activity
BEST7613_0819	COG4585	Histidine kinase
BEST7613_0820	COG2197	response regulator
BEST7613_0821	COG1131	(ABC) transporter
BEST7613_0822	COG0842	Transport permease protein
BEST7613_0822	COG1511	domain protein
BEST7613_0823	COG0842	Transport permease protein
BEST7613_0824	COG1695	Transcriptional regulator
BEST7613_0825	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BEST7613_0826	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BEST7613_0827	COG1309	transcriptional regulator
BEST7613_0828	COG2814	Major facilitator Superfamily
BEST7613_0829	COG2318	DinB family
BEST7613_0830	COG2814	Major facilitator Superfamily
BEST7613_0831	COG1846	Transcriptional regulator
BEST7613_0832	COG0392	lysyltransferase activity
BEST7613_0832	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BEST7613_0833	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_0835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_0836	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_0837	COG0384	phenazine biosynthesis protein PhzF
BEST7613_0838	COG0778	Nitroreductase
BEST7613_0840	COG1090	epimerase
BEST7613_0841	COG2137	regulation of response to DNA damage stimulus
BEST7613_0843	COG2814	Major facilitator Superfamily
BEST7613_0846	COG3103	Sh3 type 3 domain protein
BEST7613_0847	COG5658	integral membrane protein
BEST7613_0848	COG0596	Alpha beta hydrolase
BEST7613_0849	COG0463	Glycosyl transferase, family 2
BEST7613_0850	COG4485	Bacterial membrane protein, YfhO
BEST7613_0851	COG1988	membrane-bound metal-dependent
BEST7613_0852	COG1194	a g-specific adenine glycosylase
BEST7613_0854	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_0857	COG3557	Belongs to the UPF0374 family
BEST7613_0858	COG1132	(ABC) transporter
BEST7613_0859	COG4129	membrane
BEST7613_0860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BEST7613_0861	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BEST7613_0862	COG0735	belongs to the Fur family
BEST7613_0865	COG4326	sporulation control protein
BEST7613_0867	COG5577	PFAM Coat F domain
BEST7613_0868	COG3340	Belongs to the peptidase S51 family
BEST7613_0869	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BEST7613_0870	COG0277	FAD linked oxidase domain protein
BEST7613_0872	COG0753	catalase activity
BEST7613_0873	COG1116	anion transmembrane transporter activity
BEST7613_0874	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7613_0875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7613_0876	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7613_0878	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BEST7613_0880	COG1476	TRANSCRIPTIONal
BEST7613_0881	COG3382	B3 4 domain protein
BEST7613_0882	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BEST7613_0884	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BEST7613_0885	COG0789	Transcriptional regulator
BEST7613_0886	COG1664	Polymer-forming cytoskeletal
BEST7613_0887	COG1664	Polymer-forming cytoskeletal
BEST7613_0888	COG2766	serine protein kinase
BEST7613_0889	COG2718	Belongs to the UPF0229 family
BEST7613_0890	COG1846	Transcriptional regulator
BEST7613_0891	COG1566	PFAM secretion protein HlyD family protein
BEST7613_0892	COG2814	Major facilitator Superfamily
BEST7613_0893	COG0655	NAD(P)H dehydrogenase (quinone) activity
BEST7613_0896	COG1725	Transcriptional regulator
BEST7613_0897	COG1131	(ABC) transporter
BEST7613_0898	COG1131	(ABC) transporter
BEST7613_0899	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7613_0900	COG1278	Cold shock
BEST7613_0901	COG1464	Belongs to the NlpA lipoprotein family
BEST7613_0902	COG3706	GGDEF domain
BEST7613_0903	COG1823	symporter activity
BEST7613_0907	COG5577	PFAM Coat F domain
BEST7613_0908	COG4085	toxin activity
BEST7613_0908	COG1525	nuclease
BEST7613_0908	COG0737	Belongs to the 5'-nucleotidase family
BEST7613_0909	COG3764	Sortase (surface protein transpeptidase)
BEST7613_0910	COG0564	pseudouridine synthase activity
BEST7613_0912	COG0517	IMP dehydrogenase activity
BEST7613_0913	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BEST7613_0914	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7613_0914	COG3153	acetyltransferase
BEST7613_0916	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7613_0917	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BEST7613_0918	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BEST7613_0919	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BEST7613_0920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BEST7613_0921	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BEST7613_0922	COG2203	Gaf domain
BEST7613_0922	COG4585	Histidine kinase
BEST7613_0923	COG2197	response regulator
BEST7613_0924	COG0431	NADPH-dependent FMN reductase
BEST7613_0927	COG1388	LysM domain
BEST7613_0927	COG0791	NLP P60 protein
BEST7613_0928	COG1959	2 iron, 2 sulfur cluster binding
BEST7613_0929	COG0668	transmembrane transport
BEST7613_0930	COG2719	SpoVR family
BEST7613_0931	COG1785	Belongs to the alkaline phosphatase family
BEST7613_0932	COG0791	NLP P60 protein
BEST7613_0932	COG1388	LysM domain
BEST7613_0933	COG0583	DNA-binding transcription factor activity
BEST7613_0934	COG0372	Belongs to the citrate synthase family
BEST7613_0935	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_0936	COG0531	amino acid
BEST7613_0937	COG0733	neurotransmitter:sodium symporter activity
BEST7613_0938	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7613_0939	COG0456	acetyltransferase
BEST7613_0942	COG1595	DNA-templated transcription, initiation
BEST7613_0943	COG0667	Aldo Keto reductase
BEST7613_0944	COG0204	Acyl-transferase
BEST7613_0945	COG1253	flavin adenine dinucleotide binding
BEST7613_0946	COG0789	Transcriptional regulator
BEST7613_0947	COG0436	Aminotransferase
BEST7613_0948	COG1253	flavin adenine dinucleotide binding
BEST7613_0949	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BEST7613_0950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BEST7613_0951	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7613_0953	COG0668	transmembrane transport
BEST7613_0954	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BEST7613_0955	COG0726	polysaccharide deacetylase
BEST7613_0956	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7613_0957	COG1757	Na H antiporter
BEST7613_0958	COG0589	response to stress
BEST7613_0959	COG1132	(ABC) transporter
BEST7613_0960	COG1132	(ABC) transporter
BEST7613_0961	COG0702	epimerase
BEST7613_0964	COG0189	ligase activity
BEST7613_0965	COG0189	ligase activity
BEST7613_0966	COG4399	Belongs to the UPF0754 family
BEST7613_0967	COG3679	Belongs to the UPF0342 family
BEST7613_0968	COG4335	DNA alkylation repair
BEST7613_0969	COG0561	phosphatase activity
BEST7613_0970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7613_0971	COG0475	glutathione-regulated potassium exporter activity
BEST7613_0972	COG0490	domain, Protein
BEST7613_0974	COG1024	Enoyl-CoA hydratase
BEST7613_0976	COG4152	abc transporter atp-binding protein
BEST7613_0977	COG1668	transmembrane transport
BEST7613_0978	COG0420	3'-5' exonuclease activity
BEST7613_0979	COG4717	serine-type aminopeptidase activity
BEST7613_0980	COG3481	metal-dependent phosphohydrolase, HD sub domain
BEST7613_0982	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BEST7613_0985	COG1846	Transcriptional regulator
BEST7613_0986	COG4980	gas vesicle protein
BEST7613_0988	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BEST7613_0989	COG0537	adenosine 5'-monophosphoramidase activity
BEST7613_0990	COG1131	(ABC) transporter
BEST7613_0991	COG4473	ABC transporter
BEST7613_0993	COG1473	amidohydrolase
BEST7613_0994	COG3069	C4-dicarboxylate transmembrane transporter activity
BEST7613_0995	COG2329	Antibiotic biosynthesis monooxygenase
BEST7613_0996	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7613_0997	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BEST7613_1000	COG1309	transcriptional regulator
BEST7613_1001	COG1511	domain protein
BEST7613_1002	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7613_1003	COG4377	Putative membrane peptidase family (DUF2324)
BEST7613_1005	COG1363	Peptidase, m42
BEST7613_1006	COG4405	Protein conserved in bacteria
BEST7613_1007	COG1301	dicarboxylic acid transport
BEST7613_1008	COG1234	tRNA 3'-trailer cleavage
BEST7613_1009	COG0095	Lipoate-protein ligase
BEST7613_1010	COG0702	epimerase
BEST7613_1011	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_1013	COG0501	Belongs to the peptidase M48B family
BEST7613_1014	COG1404	Belongs to the peptidase S8 family
BEST7613_1015	COG0456	acetyltransferase
BEST7613_1016	COG0604	alcohol dehydrogenase
BEST7613_1017	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BEST7613_1018	COG0406	alpha-ribazole phosphatase activity
BEST7613_1019	COG0183	Belongs to the thiolase family
BEST7613_1020	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_1021	COG1268	BioY protein
BEST7613_1022	COG0840	transmembrane signaling receptor activity
BEST7613_1023	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7613_1023	COG0723	plastoquinol--plastocyanin reductase activity
BEST7613_1024	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_1026	COG4903	ComK protein
BEST7613_1027	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_1029	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7613_1032	COG0398	Pfam SNARE associated Golgi protein
BEST7613_1033	COG0681	Belongs to the peptidase S26 family
BEST7613_1034	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7613_1035	COG1846	Transcriptional regulator
BEST7613_1036	COG0738	Major facilitator superfamily
BEST7613_1038	COG0673	inositol 2-dehydrogenase activity
BEST7613_1039	COG0561	phosphatase activity
BEST7613_1040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7613_1041	COG1609	Transcriptional regulator
BEST7613_1042	COG3180	Ammonia monooxygenase
BEST7613_1043	COG2814	Major facilitator Superfamily
BEST7613_1043	COG0477	Major facilitator Superfamily
BEST7613_1044	COG4533	DNA binding
BEST7613_1046	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BEST7613_1047	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BEST7613_1048	COG1074	ATP-dependent DNA helicase activity
BEST7613_1049	COG0420	3'-5' exonuclease activity
BEST7613_1050	COG0419	ATPase involved in DNA repair
BEST7613_1051	COG1403	HNH endonuclease
BEST7613_1059	COG5337	Spore coat protein CotH
BEST7613_1060	COG0179	Fumarylacetoacetate (FAA) hydrolase
BEST7613_1062	COG1404	Belongs to the peptidase S8 family
BEST7613_1064	COG0367	asparagine synthase
BEST7613_1065	COG2318	DinB family
BEST7613_1066	COG1562	ergosterol biosynthetic process
BEST7613_1067	COG0534	Mate efflux family protein
BEST7613_1068	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_1068	COG2207	Transcriptional regulator
BEST7613_1069	COG1609	Transcriptional regulator
BEST7613_1070	COG0673	inositol 2-dehydrogenase activity
BEST7613_1071	COG2318	DinB family
BEST7613_1072	COG1279	arginine transmembrane transporter activity
BEST7613_1073	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BEST7613_1074	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7613_1075	COG2267	carboxylic ester hydrolase activity
BEST7613_1076	COG0529	Catalyzes the synthesis of activated sulfate
BEST7613_1077	COG2046	Belongs to the sulfate adenylyltransferase family
BEST7613_1078	COG0175	sulfate reduction
BEST7613_1079	COG2045	Belongs to the ComB family
BEST7613_1080	COG1809	phosphosulfolactate synthase activity
BEST7613_1081	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7613_1082	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7613_1083	COG2814	Major facilitator Superfamily
BEST7613_1084	COG0454	-acetyltransferase
BEST7613_1085	COG2153	protein acetylation
BEST7613_1086	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BEST7613_1086	COG0646	methionine synthase
BEST7613_1087	COG1666	GTP binding
BEST7613_1088	COG2996	Protein conserved in bacteria
BEST7613_1093	COG1695	Transcriptional regulator
BEST7613_1096	COG3227	Zinc metalloprotease (Elastase)
BEST7613_1097	COG1307	EDD domain protein, DegV family
BEST7613_1098	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7613_1101	COG0561	phosphatase activity
BEST7613_1102	COG1073	alpha beta
BEST7613_1103	COG2151	metal-sulfur cluster biosynthetic enzyme
BEST7613_1105	COG0277	FAD linked oxidase domain protein
BEST7613_1106	COG2271	Major facilitator Superfamily
BEST7613_1107	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BEST7613_1110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BEST7613_1111	COG0505	Belongs to the CarA family
BEST7613_1112	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7613_1113	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BEST7613_1116	COG2267	carboxylic ester hydrolase activity
BEST7613_1118	COG1744	ABC transporter substrate-binding protein PnrA-like
BEST7613_1121	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7613_1122	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7613_1123	COG5504	Zn-dependent protease
BEST7613_1124	COG0444	Belongs to the ABC transporter superfamily
BEST7613_1125	COG4608	Belongs to the ABC transporter superfamily
BEST7613_1128	COG0601	transmembrane transport
BEST7613_1129	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7613_1131	COG0180	Tryptophanyl-tRNA synthetase
BEST7613_1132	COG4166	transmembrane transport
BEST7613_1133	COG0601	transmembrane transport
BEST7613_1134	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7613_1135	COG0444	Belongs to the ABC transporter superfamily
BEST7613_1136	COG4608	Belongs to the ABC transporter superfamily
BEST7613_1137	COG2814	Major facilitator Superfamily
BEST7613_1138	COG0456	acetyltransferase
BEST7613_1139	COG1393	Belongs to the ArsC family
BEST7613_1140	COG0861	Integral membrane protein TerC family
BEST7613_1141	COG4862	establishment of competence for transformation
BEST7613_1142	COG4469	Competence protein
BEST7613_1143	COG1164	Oligoendopeptidase f
BEST7613_1146	COG2346	COG2346, Truncated hemoglobins
BEST7613_1147	COG0741	lytic transglycosylase activity
BEST7613_1148	COG4116	CYTH
BEST7613_1150	COG2357	RelA SpoT domain protein
BEST7613_1151	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7613_1152	COG0564	pseudouridine synthase activity
BEST7613_1153	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BEST7613_1154	COG0475	glutathione-regulated potassium exporter activity
BEST7613_1154	COG0569	domain protein
BEST7613_1155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BEST7613_1156	COG0352	thiamine-phosphate diphosphorylase activity
BEST7613_1157	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7613_1158	COG2104	thiamine diphosphate biosynthetic process
BEST7613_1159	COG2022	thiamine diphosphate biosynthetic process
BEST7613_1160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BEST7613_1161	COG0351	phosphomethylpyrimidine kinase
BEST7613_1162	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BEST7613_1173	COG0210	DNA helicase
BEST7613_1175	COG2153	protein acetylation
BEST7613_1176	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BEST7613_1177	COG2382	esterase
BEST7613_1178	COG0626	cystathionine gamma-synthase activity
BEST7613_1179	COG0626	cystathionine gamma-synthase activity
BEST7613_1180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_1181	COG5505	Protein of unknown function (DUF819)
BEST7613_1187	COG3677	Transposase
BEST7613_1190	COG5484	DNA packaging
BEST7613_1191	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BEST7613_1192	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_1194	COG3711	transcriptional antiterminator
BEST7613_1194	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_1195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_1195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7613_1195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7613_1196	COG1482	cell wall glycoprotein biosynthetic process
BEST7613_1198	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_1200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BEST7613_1204	COG0109	protoheme IX farnesyltransferase activity
BEST7613_1206	COG0726	polysaccharide deacetylase
BEST7613_1209	COG5504	Zn-dependent protease
BEST7613_1210	COG2205	protein histidine kinase activity
BEST7613_1212	COG3383	formate dehydrogenase (NAD+) activity
BEST7613_1213	COG2427	Protein of unknown function (DUF1641)
BEST7613_1215	COG1051	belongs to the nudix hydrolase family
BEST7613_1217	COG2124	cytochrome p450
BEST7613_1218	COG1819	glycosyl
BEST7613_1220	COG1587	Uroporphyrinogen-III synthase
BEST7613_1221	COG0390	transport system, permease component
BEST7613_1222	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7613_1223	COG0697	spore germination
BEST7613_1224	COG4297	protein containing double-stranded beta helix domain
BEST7613_1226	COG1252	NADH dehydrogenase
BEST7613_1227	COG1904	glucuronate isomerase
BEST7613_1228	COG2211	Major facilitator Superfamily
BEST7613_1229	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BEST7613_1230	COG1063	alcohol dehydrogenase
BEST7613_1231	COG1312	Catalyzes the dehydration of D-mannonate
BEST7613_1232	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_1233	COG2271	Major facilitator Superfamily
BEST7613_1234	COG1609	Transcriptional regulator
BEST7613_1235	COG0246	Mannitol dehydrogenase
BEST7613_1236	COG2721	sulfolactate sulfo-lyase activity
BEST7613_1237	COG0730	response to heat
BEST7613_1238	COG2318	DinB family
BEST7613_1239	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7613_1240	COG0457	Tetratricopeptide repeat
BEST7613_1242	COG2350	Protein conserved in bacteria
BEST7613_1243	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_1243	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7613_1243	COG1388	LysM domain
BEST7613_1245	COG4195	phage-related replication protein
BEST7613_1246	COG3546	catalase activity
BEST7613_1247	COG2856	Zn peptidase
BEST7613_1248	COG1396	sequence-specific DNA binding
BEST7613_1250	COG1522	sequence-specific DNA binding
BEST7613_1251	COG1484	DNA-dependent DNA replication
BEST7613_1255	COG1595	DNA-templated transcription, initiation
BEST7613_1256	COG3728	DNA packaging
BEST7613_1256	COG5484	DNA packaging
BEST7613_1257	COG1783	phage Terminase large subunit
BEST7613_1258	COG5518	Phage portal protein
BEST7613_1259	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BEST7613_1260	COG4653	Phage capsid family
BEST7613_1270	COG5412	phage tail tape measure protein
BEST7613_1270	COG3953	SLT domain
BEST7613_1271	COG1652	LysM domain
BEST7613_1272	COG4193	domain, Protein
BEST7613_1274	COG3628	GPW Gp25 family protein
BEST7613_1275	COG3299	homolog of phage Mu protein gp47
BEST7613_1276	COG3778	Protein conserved in bacteria
BEST7613_1284	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7613_1284	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_1287	COG0306	phosphate transporter
BEST7613_1288	COG1392	Phosphate transport regulator
BEST7613_1289	COG0531	amino acid
BEST7613_1290	COG0346	lactoylglutathione lyase activity
BEST7613_1292	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BEST7613_1293	COG0463	Glycosyl transferase, family 2
BEST7613_1295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7613_1296	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7613_1297	COG2362	D-Aminopeptidase
BEST7613_1298	COG0601	transmembrane transport
BEST7613_1299	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7613_1300	COG0444	Belongs to the ABC transporter superfamily
BEST7613_1301	COG4166	transmembrane transport
BEST7613_1302	COG1619	proteins homologs of microcin C7 resistance protein MccF
BEST7613_1303	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7613_1304	COG0791	NLP P60 protein
BEST7613_1305	COG4608	Belongs to the ABC transporter superfamily
BEST7613_1306	COG2706	6-phosphogluconolactonase activity
BEST7613_1307	COG1834	amidinotransferase
BEST7613_1308	COG1607	acyl-coa hydrolase
BEST7613_1309	COG1017	nitric oxide dioxygenase activity
BEST7613_1309	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BEST7613_1311	COG2323	membrane
BEST7613_1312	COG2318	DinB family
BEST7613_1313	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_1314	COG2076	Multidrug Resistance protein
BEST7613_1315	COG2076	Multidrug Resistance protein
BEST7613_1316	COG0788	formyltetrahydrofolate deformylase activity
BEST7613_1317	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7613_1324	COG1136	(ABC) transporter
BEST7613_1324	COG0577	efflux transmembrane transporter activity
BEST7613_1325	COG0735	belongs to the Fur family
BEST7613_1327	COG0138	bifunctional purine biosynthesis protein purh
BEST7613_1331	COG0515	serine threonine protein kinase
BEST7613_1336	COG0587	DNA-directed DNA polymerase activity
BEST7613_1338	COG0481	GTPase activity
BEST7613_1339	COG0435	Glutathione S-transferase
BEST7613_1342	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BEST7613_1342	COG0140	phosphoribosyl-ATP diphosphatase activity
BEST7613_1343	COG0523	cobalamin synthesis protein
BEST7613_1345	COG0142	geranyltranstransferase activity
BEST7613_1346	COG1187	pseudouridine synthase activity
BEST7613_1348	COG0515	serine threonine protein kinase
BEST7613_1349	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BEST7613_1350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7613_1351	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BEST7613_1353	COG1166	arginine decarboxylase activity
BEST7613_1354	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BEST7613_1356	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_1357	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_1358	COG1120	ATPase activity
BEST7613_1359	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_1361	COG4977	sequence-specific DNA binding
BEST7613_1366	COG2207	Transcriptional regulator
BEST7613_1367	COG2226	methyltransferase
BEST7613_1369	COG0848	biopolymer transport protein
BEST7613_1370	COG0811	peptide transport
BEST7613_1374	COG1132	(ABC) transporter
BEST7613_1378	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_1379	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_1381	COG1132	(ABC) transporter
BEST7613_1390	COG0409	Hydrogenase expression formation protein
BEST7613_1391	COG1091	dTDP-4-dehydrorhamnose reductase activity
BEST7613_1392	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7613_1393	COG0297	glycogen (starch) synthase activity
BEST7613_1396	COG1131	(ABC) transporter
BEST7613_1399	COG2318	DinB family
BEST7613_1403	COG1214	PFAM Peptidase M22, glycoprotease
BEST7613_1407	COG1615	UPF0182 protein
BEST7613_1410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BEST7613_1411	COG0563	adenylate kinase activity
BEST7613_1412	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BEST7613_1416	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BEST7613_1419	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7613_1420	COG0194	GDP metabolic process
BEST7613_1421	COG0406	alpha-ribazole phosphatase activity
BEST7613_1423	COG0730	response to heat
BEST7613_1424	COG1413	lyase activity
BEST7613_1427	COG0330	HflC and HflK could
BEST7613_1428	COG1530	ribonuclease E activity
BEST7613_1429	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BEST7613_1430	COG0494	nUDIX hydrolase
BEST7613_1431	COG1185	polyribonucleotide nucleotidyltransferase activity
BEST7613_1432	COG0681	Belongs to the peptidase S26 family
BEST7613_1435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BEST7613_1437	COG1401	restriction endodeoxyribonuclease activity
BEST7613_1438	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BEST7613_1439	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BEST7613_1448	COG1104	cysteine desulfurase activity
BEST7613_1453	COG0582	viral genome integration into host DNA
BEST7613_1455	COG2022	thiamine diphosphate biosynthetic process
BEST7613_1455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7613_1458	COG5002	protein histidine kinase activity
BEST7613_1460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7613_1464	COG0704	Plays a role in the regulation of phosphate uptake
BEST7613_1465	COG0779	Required for maturation of 30S ribosomal subunits
BEST7613_1466	COG0195	Participates in both transcription termination and antitermination
BEST7613_1468	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BEST7613_1473	COG2875	Belongs to the precorrin methyltransferase family
BEST7613_1476	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BEST7613_1478	COG0011	TIGRFAM Protein of
BEST7613_1479	COG0589	response to stress
BEST7613_1481	COG0123	including yeast histone deacetylase and acetoin utilization protein
BEST7613_1482	COG0010	Belongs to the arginase family
BEST7613_1483	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BEST7613_1491	COG2099	Precorrin-6x reductase
BEST7613_1494	COG1007	ATP synthesis coupled electron transport
BEST7613_1499	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BEST7613_1500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BEST7613_1501	COG0426	domain, Protein
BEST7613_1501	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7613_1503	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7613_1503	COG0426	domain, Protein
BEST7613_1505	COG0793	Belongs to the peptidase S41A family
BEST7613_1506	COG0009	L-threonylcarbamoyladenylate synthase
BEST7613_1507	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BEST7613_1508	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BEST7613_1509	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BEST7613_1510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BEST7613_1511	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BEST7613_1513	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BEST7613_1514	COG0356	it plays a direct role in the translocation of protons across the membrane
BEST7613_1516	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BEST7613_1519	COG0714	Associated with various cellular activities
BEST7613_1520	COG0316	Belongs to the HesB IscA family
BEST7613_1521	COG0697	spore germination
BEST7613_1523	COG1127	ABC transporter
BEST7613_1525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BEST7613_1529	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7613_1532	COG0163	prenyltransferase activity
BEST7613_1534	COG0589	response to stress
BEST7613_1536	COG1716	ATPase activity
BEST7613_1536	COG5001	Diguanylate cyclase
BEST7613_1541	COG1234	tRNA 3'-trailer cleavage
BEST7613_1543	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BEST7613_1546	COG0631	protein serine/threonine phosphatase activity
BEST7613_1548	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BEST7613_1548	COG4451	ribulose bisphosphate carboxylase, small
BEST7613_1549	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BEST7613_1550	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BEST7613_1551	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BEST7613_1552	COG0493	'glutamate synthase
BEST7613_1562	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BEST7613_1562	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BEST7613_1565	COG1982	Orn Lys Arg decarboxylase major
BEST7613_1566	COG0686	Belongs to the AlaDH PNT family
BEST7613_1567	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BEST7613_1571	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7613_1573	COG0673	inositol 2-dehydrogenase activity
BEST7613_1574	COG0700	Nucleoside recognition
BEST7613_1575	COG2715	membrane protein required for spore maturation
BEST7613_1576	COG1640	4-alpha-glucanotransferase
BEST7613_1578	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BEST7613_1581	COG5001	Diguanylate cyclase
BEST7613_1581	COG4251	negative regulation of phosphorylation
BEST7613_1581	COG3706	GGDEF domain
BEST7613_1581	COG2203	Gaf domain
BEST7613_1585	COG0175	sulfate reduction
BEST7613_1586	COG1420	regulation of RNA biosynthetic process
BEST7613_1587	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BEST7613_1588	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BEST7613_1590	COG0003	Pfam Anion-transporting ATPase
BEST7613_1591	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7613_1594	COG0484	heat shock protein binding
BEST7613_1595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_1597	COG0463	Glycosyl transferase, family 2
BEST7613_1597	COG1216	Glycosyl transferase, family 2
BEST7613_1599	COG1605	Chorismate mutase
BEST7613_1599	COG0077	Prephenate dehydratase
BEST7613_1600	COG3706	GGDEF domain
BEST7613_1600	COG2203	Gaf domain
BEST7613_1600	COG5001	Diguanylate cyclase
BEST7613_1600	COG4251	negative regulation of phosphorylation
BEST7613_1603	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BEST7613_1609	COG0589	response to stress
BEST7613_1610	COG2226	methyltransferase
BEST7613_1614	COG0538	isocitrate dehydrogenase activity
BEST7613_1615	COG4636	protein conserved in cyanobacteria
BEST7613_1617	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_1621	COG1840	ABC-type Fe3 transport system, periplasmic component
BEST7613_1622	COG0336	Belongs to the RNA methyltransferase TrmD family
BEST7613_1624	COG0205	6-phosphofructokinase activity
BEST7613_1625	COG1289	transmembrane transporter activity
BEST7613_1626	COG1555	photosystem II stabilization
BEST7613_1629	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7613_1630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7613_1631	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BEST7613_1636	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BEST7613_1637	COG0277	FAD linked oxidase domain protein
BEST7613_1641	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BEST7613_1643	COG0408	coproporphyrinogen oxidase activity
BEST7613_1644	COG5398	heme oxygenase
BEST7613_1646	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BEST7613_1649	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7613_1650	COG0672	)-iron permease
BEST7613_1651	COG0592	DNA-directed DNA polymerase activity
BEST7613_1652	COG0159	tryptophan synthase activity
BEST7613_1655	COG0436	Aminotransferase
BEST7613_1657	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BEST7613_1660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BEST7613_1662	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BEST7613_1663	COG0701	Predicted permease
BEST7613_1667	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BEST7613_1668	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7613_1669	COG4636	protein conserved in cyanobacteria
BEST7613_1670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BEST7613_1673	COG0489	protein tyrosine kinase activity
BEST7613_1673	COG3206	protein involved in exopolysaccharide biosynthesis
BEST7613_1681	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BEST7613_1689	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7613_1690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7613_1691	COG1088	dTDP-glucose 4,6-dehydratase activity
BEST7613_1692	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BEST7613_1696	COG1215	transferase activity, transferring glycosyl groups
BEST7613_1698	COG1215	transferase activity, transferring glycosyl groups
BEST7613_1699	COG0438	transferase activity, transferring glycosyl groups
BEST7613_1704	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BEST7613_1709	COG0297	glycogen (starch) synthase activity
BEST7613_1710	COG0438	transferase activity, transferring glycosyl groups
BEST7613_1711	COG1598	PFAM Uncharacterised protein family UPF0150
BEST7613_1713	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BEST7613_1719	COG0110	maltose O-acetyltransferase activity
BEST7613_1722	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7613_1724	COG3781	membrane
BEST7613_1725	COG0045	succinate-CoA ligase (ADP-forming) activity
BEST7613_1726	COG0861	Integral membrane protein TerC family
BEST7613_1727	COG2268	Band 7 protein
BEST7613_1728	COG0463	Glycosyl transferase, family 2
BEST7613_1729	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BEST7613_1731	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_1732	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BEST7613_1733	COG0004	ammonium transporteR
BEST7613_1734	COG0745	RESPONSE REGULATOR receiver
BEST7613_1737	COG0737	Belongs to the 5'-nucleotidase family
BEST7613_1738	COG0529	Catalyzes the synthesis of activated sulfate
BEST7613_1739	COG0811	peptide transport
BEST7613_1740	COG0848	biopolymer transport protein
BEST7613_1741	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BEST7613_1741	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7613_1743	COG0530	calcium, potassium:sodium antiporter activity
BEST7613_1747	COG0745	RESPONSE REGULATOR receiver
BEST7613_1748	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7613_1754	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BEST7613_1755	COG4251	negative regulation of phosphorylation
BEST7613_1755	COG5001	Diguanylate cyclase
BEST7613_1755	COG3706	GGDEF domain
BEST7613_1755	COG2203	Gaf domain
BEST7613_1757	COG0471	metal ion transport
BEST7613_1757	COG3273	potassium ion transport
BEST7613_1764	COG3854	ATPases associated with a variety of cellular activities
BEST7613_1765	COG0352	thiamine-phosphate diphosphorylase activity
BEST7613_1766	COG0434	BtpA family
BEST7613_1770	COG0564	pseudouridine synthase activity
BEST7613_1771	COG2203	Gaf domain
BEST7613_1771	COG5001	Diguanylate cyclase
BEST7613_1771	COG4251	negative regulation of phosphorylation
BEST7613_1771	COG3706	GGDEF domain
BEST7613_1773	COG0475	glutathione-regulated potassium exporter activity
BEST7613_1779	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BEST7613_1780	COG1733	regulation of RNA biosynthetic process
BEST7613_1781	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BEST7613_1789	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BEST7613_1792	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7613_1793	COG1487	ribonuclease activity
BEST7613_1797	COG2361	Protein of unknown function DUF86
BEST7613_1800	COG0067	glutamate synthase
BEST7613_1800	COG0069	glutamate synthase activity
BEST7613_1800	COG0070	glutamate synthase
BEST7613_1804	COG2133	pyrroloquinoline quinone binding
BEST7613_1805	COG1797	cobyrinic acid a,c-diamide synthase activity
BEST7613_1806	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BEST7613_1808	COG1022	Amp-dependent synthetase and ligase
BEST7613_1809	COG0784	Response regulator, receiver
BEST7613_1812	COG0840	transmembrane signaling receptor activity
BEST7613_1812	COG2203	Gaf domain
BEST7613_1813	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BEST7613_1814	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7613_1815	COG2203	Gaf domain
BEST7613_1815	COG3706	GGDEF domain
BEST7613_1815	COG5001	Diguanylate cyclase
BEST7613_1815	COG4251	negative regulation of phosphorylation
BEST7613_1816	COG0419	ATPase involved in DNA repair
BEST7613_1817	COG0484	heat shock protein binding
BEST7613_1818	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BEST7613_1820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BEST7613_1824	COG1429	ligase activity, forming nitrogen-metal bonds
BEST7613_1827	COG3956	TIGRFAM MazG family protein
BEST7613_1829	COG5002	protein histidine kinase activity
BEST7613_1834	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BEST7613_1837	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BEST7613_1838	COG1247	-acetyltransferase
BEST7613_1839	COG0174	glutamine synthetase
BEST7613_1841	COG4251	negative regulation of phosphorylation
BEST7613_1841	COG5001	Diguanylate cyclase
BEST7613_1841	COG3706	GGDEF domain
BEST7613_1841	COG2203	Gaf domain
BEST7613_1843	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BEST7613_1844	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BEST7613_1847	COG2310	stress, protein
BEST7613_1848	COG0076	glutamate decarboxylase activity
BEST7613_1851	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7613_1852	COG0829	nickel cation binding
BEST7613_1855	COG1045	serine acetyltransferase
BEST7613_1858	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BEST7613_1861	COG0271	Belongs to the BolA IbaG family
BEST7613_1862	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BEST7613_1863	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BEST7613_1867	COG0804	urea catabolic process
BEST7613_1870	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7613_1874	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BEST7613_1875	COG1773	rubredoxin
BEST7613_1876	COG4447	cellulose binding
BEST7613_1881	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7613_1884	COG3385	transposase activity
BEST7613_1888	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7613_1890	COG3228	Belongs to the MtfA family
BEST7613_1897	COG1121	(ABC) transporter
BEST7613_1898	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7613_1901	COG1702	phosphate starvation-inducible protein PhoH
BEST7613_1904	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7613_1908	COG0484	heat shock protein binding
BEST7613_1909	COG0443	Heat shock 70 kDa protein
BEST7613_1910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BEST7613_1916	COG3659	wide pore channel activity
BEST7613_1918	COG2247	cell wall binding repeat
BEST7613_1918	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7613_1930	COG0768	penicillin binding
BEST7613_1932	COG0247	lactate metabolic process
BEST7613_1934	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BEST7613_1936	COG0583	DNA-binding transcription factor activity
BEST7613_1938	COG0384	phenazine biosynthesis protein PhzF
BEST7613_1939	COG2319	Wd-40 repeat
BEST7613_1940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7613_1941	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7613_1946	COG0475	glutathione-regulated potassium exporter activity
BEST7613_1946	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BEST7613_1947	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BEST7613_1952	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BEST7613_1954	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BEST7613_1955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7613_1958	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7613_1959	COG0629	single-stranded DNA binding
BEST7613_1962	COG0668	transmembrane transport
BEST7613_1964	COG0745	RESPONSE REGULATOR receiver
BEST7613_1965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7613_1965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BEST7613_1966	COG3937	granule-associated protein
BEST7613_1969	COG2226	methyltransferase
BEST7613_1971	COG0681	Belongs to the peptidase S26 family
BEST7613_1973	COG1271	oxidase subunit
BEST7613_1974	COG1294	oxidase, subunit
BEST7613_1975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BEST7613_1976	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BEST7613_1977	COG0412	Dienelactone hydrolase
BEST7613_1987	COG2203	Gaf domain
BEST7613_1987	COG0840	transmembrane signaling receptor activity
BEST7613_1990	COG0784	Response regulator, receiver
BEST7613_1991	COG0557	exoribonuclease II activity
BEST7613_1993	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7613_1996	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BEST7613_1998	COG5002	protein histidine kinase activity
BEST7613_1999	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BEST7613_2001	COG1309	transcriptional regulator
BEST7613_2006	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BEST7613_2008	COG2385	sporulation resulting in formation of a cellular spore
BEST7613_2010	COG3411	Ferredoxin
BEST7613_2011	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BEST7613_2016	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BEST7613_2017	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7613_2018	COG0237	dephospho-CoA kinase activity
BEST7613_2019	COG0237	dephospho-CoA kinase activity
BEST7613_2025	COG0515	serine threonine protein kinase
BEST7613_2026	COG0515	serine threonine protein kinase
BEST7613_2028	COG2988	succinylglutamate desuccinylase activity
BEST7613_2029	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7613_2031	COG0739	heme binding
BEST7613_2032	COG0587	DNA-directed DNA polymerase activity
BEST7613_2035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BEST7613_2041	COG1006	Multisubunit Na H antiporter MnhC subunit
BEST7613_2056	COG1132	(ABC) transporter
BEST7613_2057	COG3063	Type IV pilus biogenesis stability protein PilW
BEST7613_2058	COG2217	Heavy metal translocating P-type atpase
BEST7613_2059	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7613_2060	COG0745	RESPONSE REGULATOR receiver
BEST7613_2062	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7613_2063	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BEST7613_2065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BEST7613_2071	COG0557	exoribonuclease II activity
BEST7613_2073	COG2208	phosphoserine phosphatase activity
BEST7613_2075	COG0165	Argininosuccinate lyase
BEST7613_2076	COG2816	NAD+ diphosphatase activity
BEST7613_2079	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BEST7613_2080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7613_2081	COG1845	cytochrome c oxidase, subunit III
BEST7613_2082	COG3118	belongs to the thioredoxin family
BEST7613_2084	COG1116	anion transmembrane transporter activity
BEST7613_2085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7613_2088	COG0375	protein maturation
BEST7613_2089	COG0010	Belongs to the arginase family
BEST7613_2091	COG3706	GGDEF domain
BEST7613_2092	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7613_2094	COG0495	leucyl-tRNA aminoacylation
BEST7613_2095	COG0786	glutamate:sodium symporter activity
BEST7613_2097	COG2205	protein histidine kinase activity
BEST7613_2099	COG1132	(ABC) transporter
BEST7613_2103	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BEST7613_2104	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7613_2105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7613_2110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BEST7613_2111	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BEST7613_2113	COG0254	rRNA binding
BEST7613_2114	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BEST7613_2115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BEST7613_2116	COG0101	tRNA pseudouridine synthase activity
BEST7613_2117	COG0203	ribosomal protein L17
BEST7613_2118	COG0202	RNA polymerase activity
BEST7613_2119	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BEST7613_2120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BEST7613_2121	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BEST7613_2122	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BEST7613_2123	COG0563	adenylate kinase activity
BEST7613_2124	COG0201	protein transport
BEST7613_2125	COG0200	Binds to the 23S rRNA
BEST7613_2126	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BEST7613_2127	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BEST7613_2128	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BEST7613_2129	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BEST7613_2130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BEST7613_2131	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BEST7613_2132	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BEST7613_2133	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BEST7613_2134	COG0255	Belongs to the universal ribosomal protein uL29 family
BEST7613_2135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BEST7613_2136	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BEST7613_2137	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BEST7613_2138	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BEST7613_2139	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BEST7613_2140	COG0089	rRNA binding
BEST7613_2141	COG0088	Forms part of the polypeptide exit tunnel
BEST7613_2142	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BEST7613_2143	COG0783	Belongs to the Dps family
BEST7613_2147	COG2010	Cytochrome c
BEST7613_2149	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BEST7613_2150	COG0830	nickel cation binding
BEST7613_2152	COG1131	(ABC) transporter
BEST7613_2157	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BEST7613_2158	COG0085	RNA polymerase activity
BEST7613_2159	COG0084	hydrolase, TatD family'
BEST7613_2160	COG0268	Binds directly to 16S ribosomal RNA
BEST7613_2161	COG5002	protein histidine kinase activity
BEST7613_2163	COG0210	DNA helicase
BEST7613_2163	COG0210	DNA helicase
BEST7613_2164	COG1196	nuclear chromosome segregation
BEST7613_2165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7613_2170	COG0758	DNA mediated transformation
BEST7613_2170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BEST7613_2171	COG0393	Putative heavy-metal-binding
BEST7613_2173	COG0450	alkyl hydroperoxide reductase
BEST7613_2174	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BEST7613_2175	COG0559	Belongs to the binding-protein-dependent transport system permease family
BEST7613_2177	COG1175	transmembrane transport
BEST7613_2179	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7613_2184	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_2184	COG3347	Dehydrogenase
BEST7613_2188	COG4251	negative regulation of phosphorylation
BEST7613_2188	COG3706	GGDEF domain
BEST7613_2188	COG2203	Gaf domain
BEST7613_2188	COG5001	Diguanylate cyclase
BEST7613_2190	COG0784	Response regulator, receiver
BEST7613_2192	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BEST7613_2194	COG2239	Acts as a magnesium transporter
BEST7613_2200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BEST7613_2201	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BEST7613_2202	COG1799	cell septum assembly
BEST7613_2204	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BEST7613_2204	COG0662	Cupin 2, conserved barrel domain protein
BEST7613_2207	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BEST7613_2208	COG0459	protein refolding
BEST7613_2212	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BEST7613_2213	COG0222	ribosome binding
BEST7613_2214	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BEST7613_2215	COG0081	regulation of translation
BEST7613_2216	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BEST7613_2217	COG0250	Participates in transcription elongation, termination and antitermination
BEST7613_2218	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BEST7613_2219	COG0335	large ribosomal subunit rRNA binding
BEST7613_2225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BEST7613_2227	COG3243	poly(R)-hydroxyalkanoic acid synthase
BEST7613_2229	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BEST7613_2231	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_2232	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7613_2234	COG2885	chlorophyll binding
BEST7613_2235	COG2885	chlorophyll binding
BEST7613_2237	COG1132	(ABC) transporter
BEST7613_2239	COG0438	transferase activity, transferring glycosyl groups
BEST7613_2241	COG0745	RESPONSE REGULATOR receiver
BEST7613_2242	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7613_2242	COG0022	dehydrogenase e1 component
BEST7613_2243	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BEST7613_2244	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BEST7613_2245	COG1929	Belongs to the glycerate kinase type-1 family
BEST7613_2246	COG3659	wide pore channel activity
BEST7613_2247	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7613_2248	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BEST7613_2249	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BEST7613_2256	COG0776	regulation of translation
BEST7613_2259	COG0514	ATP-dependent DNA helicase (RecQ)
BEST7613_2261	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BEST7613_2262	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7613_2265	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BEST7613_2273	COG0438	transferase activity, transferring glycosyl groups
BEST7613_2274	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7613_2275	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BEST7613_2276	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7613_2279	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BEST7613_2280	COG0242	peptide deformylase activity
BEST7613_2282	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BEST7613_2289	COG0243	molybdopterin cofactor binding
BEST7613_2290	COG1116	anion transmembrane transporter activity
BEST7613_2291	COG1116	anion transmembrane transporter activity
BEST7613_2291	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7613_2292	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7613_2293	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7613_2296	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BEST7613_2297	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BEST7613_2299	COG0793	Belongs to the peptidase S41A family
BEST7613_2301	COG0275	rRNA processing
BEST7613_2303	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BEST7613_2311	COG1090	epimerase
BEST7613_2313	COG0515	serine threonine protein kinase
BEST7613_2315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BEST7613_2317	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BEST7613_2318	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BEST7613_2319	COG0659	secondary active sulfate transmembrane transporter activity
BEST7613_2320	COG0589	response to stress
BEST7613_2324	COG1053	succinate dehydrogenase
BEST7613_2325	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BEST7613_2326	COG0537	adenosine 5'-monophosphoramidase activity
BEST7613_2332	COG0402	S-adenosylhomocysteine deaminase activity
BEST7613_2335	COG2267	carboxylic ester hydrolase activity
BEST7613_2337	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BEST7613_2338	COG0189	ligase activity
BEST7613_2340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BEST7613_2341	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BEST7613_2346	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BEST7613_2347	COG0312	modulator of DNA gyrase
BEST7613_2351	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BEST7613_2353	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BEST7613_2358	COG2140	Oxalate decarboxylase
BEST7613_2359	COG0058	SHG alpha-glucan phosphorylase activity
BEST7613_2364	COG0515	serine threonine protein kinase
BEST7613_2367	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BEST7613_2367	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BEST7613_2368	COG3850	Histidine kinase
BEST7613_2368	COG2205	protein histidine kinase activity
BEST7613_2368	COG4999	Histidine kinase
BEST7613_2368	COG3437	response regulator, receiver
BEST7613_2374	COG0546	phosphoglycolate phosphatase activity
BEST7613_2375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BEST7613_2376	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BEST7613_2378	COG0501	Belongs to the peptidase M48B family
BEST7613_2379	COG0539	negative regulation of cytoplasmic translation
BEST7613_2381	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BEST7613_2382	COG1132	(ABC) transporter
BEST7613_2383	COG0469	pyruvate kinase activity
BEST7613_2387	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BEST7613_2388	COG1268	BioY protein
BEST7613_2389	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BEST7613_2393	COG3659	wide pore channel activity
BEST7613_2396	COG0058	SHG alpha-glucan phosphorylase activity
BEST7613_2398	COG0575	Belongs to the CDS family
BEST7613_2403	COG1970	mechanosensitive ion channel activity
BEST7613_2404	COG0632	four-way junction helicase activity
BEST7613_2405	COG1836	PFAM Integral membrane protein DUF92
BEST7613_2406	COG0446	pyridine nucleotide-disulphide oxidoreductase
BEST7613_2407	COG0724	RNA recognition motif
BEST7613_2408	COG0154	amidase activity
BEST7613_2409	COG0739	heme binding
BEST7613_2410	COG0509	glycine decarboxylation via glycine cleavage system
BEST7613_2413	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BEST7613_2418	COG1316	TRANSCRIPTIONal
BEST7613_2420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7613_2422	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BEST7613_2423	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BEST7613_2425	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_2429	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BEST7613_2432	COG0322	excinuclease ABC activity
BEST7613_2437	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BEST7613_2439	COG3258	Cytochrome c
BEST7613_2440	COG0723	plastoquinol--plastocyanin reductase activity
BEST7613_2445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BEST7613_2450	COG2319	Wd-40 repeat
BEST7613_2451	COG2319	Wd-40 repeat
BEST7613_2455	COG1082	Xylose isomerase domain protein TIM barrel
BEST7613_2459	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BEST7613_2464	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_2467	COG2208	phosphoserine phosphatase activity
BEST7613_2467	COG2770	Histidine kinase
BEST7613_2470	COG3385	transposase activity
BEST7613_2475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BEST7613_2476	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BEST7613_2484	COG1741	Belongs to the pirin family
BEST7613_2486	COG1193	negative regulation of DNA recombination
BEST7613_2487	COG0631	protein serine/threonine phosphatase activity
BEST7613_2488	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BEST7613_2490	COG3937	granule-associated protein
BEST7613_2495	COG1181	Belongs to the D-alanine--D-alanine ligase family
BEST7613_2496	COG3932	Exopolysaccharide synthesis, ExoD
BEST7613_2497	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BEST7613_2499	COG0360	Binds together with S18 to 16S ribosomal RNA
BEST7613_2500	COG0179	Fumarylacetoacetate (FAA) hydrolase
BEST7613_2501	COG1413	lyase activity
BEST7613_2502	COG0641	radical SAM
BEST7613_2509	COG0083	homoserine kinase activity
BEST7613_2511	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BEST7613_2512	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_2514	COG0196	riboflavin kinase activity
BEST7613_2518	COG0180	Tryptophanyl-tRNA synthetase
BEST7613_2520	COG1713	HD superfamily hydrolase involved in NAD metabolism
BEST7613_2521	COG0799	negative regulation of ribosome biogenesis
BEST7613_2523	COG0181	hydroxymethylbilane synthase activity
BEST7613_2524	COG0427	acetyl-CoA hydrolase
BEST7613_2525	COG0857	belongs to the CobB CobQ family
BEST7613_2525	COG0280	phosphate acetyltransferase
BEST7613_2527	COG1489	DNA binding
BEST7613_2529	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7613_2531	COG0602	queuosine metabolic process
BEST7613_2532	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BEST7613_2533	COG0612	Peptidase, M16
BEST7613_2534	COG0612	Peptidase, M16
BEST7613_2537	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BEST7613_2540	COG1372	Participates in initiation and elongation during chromosome replication
BEST7613_2540	COG0187	DNA topoisomerase II activity
BEST7613_2543	COG0646	methionine synthase
BEST7613_2543	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BEST7613_2545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7613_2550	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_2552	COG2197	response regulator
BEST7613_2553	COG5001	Diguanylate cyclase
BEST7613_2553	COG4251	negative regulation of phosphorylation
BEST7613_2553	COG3706	GGDEF domain
BEST7613_2553	COG2203	Gaf domain
BEST7613_2555	COG0616	signal peptide processing
BEST7613_2557	COG0596	Alpha beta hydrolase
BEST7613_2558	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BEST7613_2560	COG0747	negative chemotaxis
BEST7613_2562	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
BEST7613_2570	COG4968	Prepilin-type N-terminal cleavage methylation domain
BEST7613_2571	COG4968	Prepilin-type N-terminal cleavage methylation domain
BEST7613_2576	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7613_2577	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7613_2578	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BEST7613_2580	COG2199	diguanylate cyclase activity
BEST7613_2581	COG0750	zinc metalloprotease
BEST7613_2582	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BEST7613_2584	COG0590	tRNA wobble adenosine to inosine editing
BEST7613_2586	COG0415	Belongs to the DNA photolyase family
BEST7613_2589	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_2589	COG3429	Glucose-6-phosphate dehydrogenase subunit
BEST7613_2591	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BEST7613_2592	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BEST7613_2594	COG1122	ATPase activity
BEST7613_2595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BEST7613_2597	COG0678	peroxiredoxin activity
BEST7613_2604	COG1252	NADH dehydrogenase
BEST7613_2606	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BEST7613_2611	COG0415	Belongs to the DNA photolyase family
BEST7613_2614	COG1595	DNA-templated transcription, initiation
BEST7613_2622	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BEST7613_2624	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BEST7613_2625	COG3339	Conserved Protein
BEST7613_2627	COG0312	modulator of DNA gyrase
BEST7613_2628	COG0482	sulfurtransferase activity
BEST7613_2631	COG0488	(ABC) transporter
BEST7613_2632	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BEST7613_2634	COG0284	orotidine-5'-phosphate decarboxylase activity
BEST7613_2643	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BEST7613_2645	COG0697	spore germination
BEST7613_2652	COG0583	DNA-binding transcription factor activity
BEST7613_2658	COG2814	Major facilitator Superfamily
BEST7613_2659	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7613_2660	COG0573	inorganic phosphate transmembrane transporter activity
BEST7613_2661	COG0581	inorganic phosphate transmembrane transporter activity
BEST7613_2662	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7613_2663	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BEST7613_2664	COG2154	pterin-4-alpha-carbinolamine dehydratase
BEST7613_2669	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BEST7613_2669	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BEST7613_2670	COG1562	ergosterol biosynthetic process
BEST7613_2671	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BEST7613_2672	COG0831	urea catabolic process
BEST7613_2673	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BEST7613_2677	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7613_2680	COG2188	Transcriptional regulator
BEST7613_2683	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BEST7613_2684	COG0640	Transcriptional regulator
BEST7613_2685	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BEST7613_2686	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BEST7613_2686	COG1754	DNA topoisomerase type I activity
BEST7613_2693	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BEST7613_2699	COG2264	protein methyltransferase activity
BEST7613_2700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BEST7613_2703	COG0386	Belongs to the glutathione peroxidase family
BEST7613_2704	COG0183	Belongs to the thiolase family
BEST7613_2705	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_2707	COG2205	protein histidine kinase activity
BEST7613_2707	COG4999	Histidine kinase
BEST7613_2707	COG3850	Histidine kinase
BEST7613_2707	COG3437	response regulator, receiver
BEST7613_2711	COG4242	Belongs to the peptidase S51 family
BEST7613_2712	COG0189	ligase activity
BEST7613_2712	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BEST7613_2719	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BEST7613_2720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7613_2722	COG0285	dihydrofolate synthase activity
BEST7613_2726	COG4636	protein conserved in cyanobacteria
BEST7613_2729	COG1606	tRNA processing
BEST7613_2731	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BEST7613_2732	COG2045	Belongs to the ComB family
BEST7613_2733	COG0778	Nitroreductase
BEST7613_2734	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BEST7613_2736	COG0516	GMP reductase activity
BEST7613_2737	COG0395	ABC-type sugar transport system, permease component
BEST7613_2738	COG3268	Saccharopine dehydrogenase
BEST7613_2741	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7613_2742	COG1121	(ABC) transporter
BEST7613_2743	COG0803	Belongs to the bacterial solute-binding protein 9 family
BEST7613_2745	COG4251	negative regulation of phosphorylation
BEST7613_2746	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BEST7613_2748	COG0583	DNA-binding transcription factor activity
BEST7613_2749	COG0025	NhaP-type Na H and K H
BEST7613_2750	COG2197	response regulator
BEST7613_2751	COG5002	protein histidine kinase activity
BEST7613_2752	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BEST7613_2753	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BEST7613_2755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BEST7613_2756	COG2205	protein histidine kinase activity
BEST7613_2758	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BEST7613_2762	COG2385	sporulation resulting in formation of a cellular spore
BEST7613_2763	COG0649	NAD binding
BEST7613_2766	COG0429	hydrolase of the alpha beta-hydrolase fold
BEST7613_2768	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BEST7613_2769	COG3536	Protein conserved in bacteria
BEST7613_2770	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BEST7613_2771	COG0716	FMN binding
BEST7613_2773	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BEST7613_2774	COG0012	GTP binding
BEST7613_2775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BEST7613_2787	COG3842	ATPase activity
BEST7613_2789	COG1840	ABC-type Fe3 transport system, periplasmic component
BEST7613_2790	COG0222	ribosome binding
BEST7613_2792	COG2066	Belongs to the glutaminase family
BEST7613_2796	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7613_2799	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BEST7613_2800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BEST7613_2801	COG1333	cytochrome c biogenesis protein
BEST7613_2803	COG1657	PFAM Prenyltransferase squalene oxidase
BEST7613_2812	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_2814	COG1494	fructose-1,6-bisphosphatase
BEST7613_2816	COG2346	COG2346, Truncated hemoglobins
BEST7613_2817	COG3437	response regulator, receiver
BEST7613_2817	COG4999	Histidine kinase
BEST7613_2817	COG3850	Histidine kinase
BEST7613_2817	COG2205	protein histidine kinase activity
BEST7613_2819	COG3437	response regulator, receiver
BEST7613_2820	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_2821	COG0552	protein localization to endoplasmic reticulum
BEST7613_2823	COG2205	protein histidine kinase activity
BEST7613_2823	COG0784	Response regulator, receiver
BEST7613_2823	COG5002	protein histidine kinase activity
BEST7613_2824	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BEST7613_2826	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7613_2830	COG0667	Aldo Keto reductase
BEST7613_2831	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7613_2834	COG0442	prolyl-tRNA aminoacylation
BEST7613_2836	COG4372	Transposase
BEST7613_2837	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7613_2842	COG0438	transferase activity, transferring glycosyl groups
BEST7613_2843	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BEST7613_2844	COG0416	fatty acid biosynthetic process
BEST7613_2845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7613_2848	COG0347	Belongs to the P(II) protein family
BEST7613_2849	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7613_2855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BEST7613_2856	COG0473	3-isopropylmalate dehydrogenase activity
BEST7613_2858	COG1575	Belongs to the MenA family. Type 1 subfamily
BEST7613_2860	COG0656	L-ascorbic acid biosynthetic process
BEST7613_2866	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7613_2868	COG1215	transferase activity, transferring glycosyl groups
BEST7613_2873	COG1216	Glycosyl transferase, family 2
BEST7613_2874	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BEST7613_2877	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_2883	COG0463	Glycosyl transferase, family 2
BEST7613_2884	COG0113	porphobilinogen synthase activity
BEST7613_2886	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BEST7613_2887	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BEST7613_2893	COG0312	modulator of DNA gyrase
BEST7613_2894	COG2890	protein-(glutamine-N5) methyltransferase activity
BEST7613_2895	COG2205	protein histidine kinase activity
BEST7613_2898	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BEST7613_2899	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BEST7613_2904	COG0438	transferase activity, transferring glycosyl groups
BEST7613_2906	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_2906	COG2205	protein histidine kinase activity
BEST7613_2907	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BEST7613_2908	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BEST7613_2909	COG0612	Peptidase, M16
BEST7613_2910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7613_2911	COG3259	Nickel-dependent hydrogenase
BEST7613_2914	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
BEST7613_2915	COG1034	ATP synthesis coupled electron transport
BEST7613_2922	COG0702	epimerase
BEST7613_2929	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BEST7613_2930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BEST7613_2933	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BEST7613_2935	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BEST7613_2936	COG0673	inositol 2-dehydrogenase activity
BEST7613_2940	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BEST7613_2948	COG0095	Lipoate-protein ligase
BEST7613_2951	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BEST7613_2953	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BEST7613_2955	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BEST7613_2956	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BEST7613_2957	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7613_2958	COG0457	Tetratricopeptide repeat
BEST7613_2959	COG1160	GTP binding
BEST7613_2963	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BEST7613_2965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BEST7613_2966	COG0052	Belongs to the universal ribosomal protein uS2 family
BEST7613_2967	COG0387	Pfam Sodium calcium exchanger
BEST7613_2968	COG0717	Belongs to the dCTP deaminase family
BEST7613_2975	COG3385	transposase activity
BEST7613_2976	COG1253	flavin adenine dinucleotide binding
BEST7613_2978	COG3046	protein related to deoxyribodipyrimidine photolyase
BEST7613_2979	COG0516	GMP reductase activity
BEST7613_2979	COG0517	IMP dehydrogenase activity
BEST7613_2981	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BEST7613_2985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BEST7613_2985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BEST7613_2986	COG0288	reversible hydration of carbon dioxide
BEST7613_2987	COG1045	serine acetyltransferase
BEST7613_2988	COG0166	Belongs to the GPI family
BEST7613_2989	COG3239	Fatty acid desaturase
BEST7613_2990	COG1672	PFAM Archaeal ATPase
BEST7613_2991	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BEST7613_2992	COG2010	Cytochrome c
BEST7613_2993	COG0359	binds to the 23S rRNA
BEST7613_2995	COG1032	radical SAM domain protein
BEST7613_3001	COG0298	carbon dioxide binding
BEST7613_3002	COG0109	protoheme IX farnesyltransferase activity
BEST7613_3003	COG1612	heme a metabolic process
BEST7613_3008	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BEST7613_3009	COG1716	ATPase activity
BEST7613_3009	COG5001	Diguanylate cyclase
BEST7613_3015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7613_3016	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BEST7613_3017	COG1764	response to oxidative stress
BEST7613_3018	COG1846	Transcriptional regulator
BEST7613_3019	COG1764	response to oxidative stress
BEST7613_3021	COG0590	tRNA wobble adenosine to inosine editing
BEST7613_3022	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7613_3023	COG1404	Belongs to the peptidase S8 family
BEST7613_3024	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_3025	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BEST7613_3026	COG1122	ATPase activity
BEST7613_3027	COG4721	ABC-type cobalt transport system, permease component
BEST7613_3029	COG0745	RESPONSE REGULATOR receiver
BEST7613_3030	COG5002	protein histidine kinase activity
BEST7613_3030	COG3850	Histidine kinase
BEST7613_3031	COG3212	peptidase
BEST7613_3032	COG3212	peptidase
BEST7613_3035	COG2239	Acts as a magnesium transporter
BEST7613_3036	COG0789	Transcriptional regulator
BEST7613_3039	COG1846	Transcriptional regulator
BEST7613_3040	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7613_3041	COG0726	polysaccharide deacetylase
BEST7613_3042	COG1408	metallophosphoesterase
BEST7613_3044	COG0463	Glycosyl transferase, family 2
BEST7613_3045	COG1793	dna ligase
BEST7613_3045	COG3285	dna ligase
BEST7613_3046	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BEST7613_3047	COG5001	Diguanylate cyclase
BEST7613_3047	COG3300	MHYT domain
BEST7613_3048	COG0586	Pfam SNARE associated Golgi protein
BEST7613_3049	COG0861	Integral membrane protein TerC family
BEST7613_3050	COG1191	sigma factor activity
BEST7613_3054	COG0501	Belongs to the peptidase M48B family
BEST7613_3055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BEST7613_3058	COG3594	Acyltransferase
BEST7613_3059	COG5002	protein histidine kinase activity
BEST7613_3060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BEST7613_3062	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BEST7613_3063	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BEST7613_3064	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7613_3065	COG0436	Aminotransferase
BEST7613_3066	COG1850	ribulose-bisphosphate carboxylase activity
BEST7613_3067	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BEST7613_3068	COG0235	Class ii aldolase
BEST7613_3069	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BEST7613_3070	COG3339	Conserved Protein
BEST7613_3073	COG3852	Histidine kinase
BEST7613_3074	COG1846	Transcriptional regulator
BEST7613_3075	COG1360	Flagellar Motor Protein
BEST7613_3076	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BEST7613_3077	COG0542	response to heat
BEST7613_3078	COG3949	Membrane
BEST7613_3079	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BEST7613_3080	COG0720	synthase
BEST7613_3081	COG0602	queuosine metabolic process
BEST7613_3082	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BEST7613_3083	COG1733	regulation of RNA biosynthetic process
BEST7613_3084	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3085	COG4641	Protein conserved in bacteria
BEST7613_3085	COG1388	LysM domain
BEST7613_3086	COG1388	LysM domain
BEST7613_3087	COG3858	chitin binding
BEST7613_3088	COG3858	chitin binding
BEST7613_3090	COG4873	Protein conserved in bacteria
BEST7613_3092	COG3773	Cell wall hydrolase
BEST7613_3093	COG2244	polysaccharide biosynthetic process
BEST7613_3094	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_3095	COG2217	Heavy metal translocating P-type atpase
BEST7613_3097	COG0006	proline dipeptidase activity
BEST7613_3099	COG1609	Transcriptional regulator
BEST7613_3100	COG3711	transcriptional antiterminator
BEST7613_3101	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_3101	COG1263	PTS System
BEST7613_3101	COG2190	(PTS) system
BEST7613_3102	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_3103	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BEST7613_3105	COG1533	DNA photolyase activity
BEST7613_3106	COG0456	acetyltransferase
BEST7613_3107	COG0840	transmembrane signaling receptor activity
BEST7613_3108	COG2084	Dehydrogenase
BEST7613_3109	COG2340	Cysteine-rich secretory protein family
BEST7613_3110	COG0768	penicillin binding
BEST7613_3111	COG4191	Histidine kinase
BEST7613_3112	COG0436	Aminotransferase
BEST7613_3114	COG0784	Response regulator, receiver
BEST7613_3114	COG0835	chemotaxis
BEST7613_3116	COG2814	Major facilitator Superfamily
BEST7613_3117	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7613_3118	COG1408	metallophosphoesterase
BEST7613_3119	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3120	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_3121	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_3123	COG2200	EAL domain
BEST7613_3124	COG4703	Protein of unknown function (DUF1797)
BEST7613_3125	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BEST7613_3127	COG0517	IMP dehydrogenase activity
BEST7613_3128	COG0583	DNA-binding transcription factor activity
BEST7613_3129	COG0716	FMN binding
BEST7613_3131	COG0716	FMN binding
BEST7613_3132	COG2171	N-acyltransferase activity
BEST7613_3133	COG1473	amidohydrolase
BEST7613_3135	COG0668	transmembrane transport
BEST7613_3136	COG0450	alkyl hydroperoxide reductase
BEST7613_3137	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_3140	COG0746	molybdenum cofactor guanylyltransferase activity
BEST7613_3141	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BEST7613_3142	COG0303	'Molybdopterin
BEST7613_3143	COG1763	Mo-molybdopterin cofactor biosynthetic process
BEST7613_3144	COG0314	molybdopterin synthase activity
BEST7613_3145	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BEST7613_3146	COG1132	(ABC) transporter
BEST7613_3147	COG1132	(ABC) transporter
BEST7613_3149	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7613_3150	COG1136	(ABC) transporter
BEST7613_3151	COG0577	efflux transmembrane transporter activity
BEST7613_3152	COG1349	DNA-binding transcription factor activity
BEST7613_3153	COG1105	Belongs to the carbohydrate kinase PfkB family
BEST7613_3154	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_3154	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7613_3154	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BEST7613_3155	COG0681	Belongs to the peptidase S26 family
BEST7613_3157	COG0488	(ABC) transporter
BEST7613_3158	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BEST7613_3159	COG2309	aminopeptidase activity
BEST7613_3161	COG1077	Cell shape determining protein MreB Mrl
BEST7613_3162	COG2002	toxin-antitoxin pair type II binding
BEST7613_3163	COG3852	Histidine kinase
BEST7613_3164	COG2105	PFAM AIG2 family protein
BEST7613_3164	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BEST7613_3165	COG0569	domain protein
BEST7613_3166	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BEST7613_3167	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BEST7613_3169	COG0561	phosphatase activity
BEST7613_3170	COG0242	peptide deformylase activity
BEST7613_3172	COG0497	DNA recombination
BEST7613_3173	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7613_3174	COG0022	dehydrogenase e1 component
BEST7613_3175	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7613_3176	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7613_3177	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_3178	COG1982	Orn Lys Arg decarboxylase major
BEST7613_3179	COG4476	Belongs to the UPF0223 family
BEST7613_3180	COG4493	Belongs to the UPF0637 family
BEST7613_3182	COG0483	inositol monophosphate 1-phosphatase activity
BEST7613_3184	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BEST7613_3188	COG1595	DNA-templated transcription, initiation
BEST7613_3194	COG4896	Protein conserved in bacteria
BEST7613_3196	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BEST7613_3197	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BEST7613_3198	COG2066	Belongs to the glutaminase family
BEST7613_3199	COG4838	Belongs to the UPF0358 family
BEST7613_3200	COG0772	Belongs to the SEDS family
BEST7613_3201	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BEST7613_3202	COG1612	heme a metabolic process
BEST7613_3203	COG0109	protoheme IX farnesyltransferase activity
BEST7613_3204	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BEST7613_3204	COG2010	Cytochrome c
BEST7613_3205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7613_3206	COG1845	cytochrome c oxidase, subunit III
BEST7613_3207	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BEST7613_3208	COG3336	cytochrome c oxidase
BEST7613_3210	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BEST7613_3211	COG2340	Cysteine-rich secretory protein family
BEST7613_3214	COG3679	Belongs to the UPF0342 family
BEST7613_3215	COG4471	UPF0298 protein
BEST7613_3216	COG0742	ribosomal rna small subunit methyltransferase
BEST7613_3217	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BEST7613_3218	COG3314	Sporulation integral membrane protein YlbJ
BEST7613_3220	COG1752	Esterase of the alpha-beta hydrolase superfamily
BEST7613_3221	COG3480	Lon protease (S16) C-terminal proteolytic domain
BEST7613_3222	COG1323	Belongs to the UPF0348 family
BEST7613_3223	COG1399	metal-binding, possibly nucleic acid-binding protein
BEST7613_3224	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BEST7613_3226	COG0454	-acetyltransferase
BEST7613_3227	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BEST7613_3228	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BEST7613_3229	COG2001	Belongs to the MraZ family
BEST7613_3230	COG0275	rRNA processing
BEST7613_3231	COG4839	cell division protein FtsL
BEST7613_3233	COG0768	penicillin binding
BEST7613_3234	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BEST7613_3235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7613_3236	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BEST7613_3237	COG0772	Belongs to the SEDS family
BEST7613_3238	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7613_3239	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BEST7613_3240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BEST7613_3241	COG3879	Bacterial protein of unknown function (DUF881)
BEST7613_3242	COG3879	Bacterial protein of unknown function (DUF881)
BEST7613_3243	COG3856	small basic protein
BEST7613_3244	COG0849	cell division
BEST7613_3245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BEST7613_3246	COG4412	M6 family metalloprotease domain protein
BEST7613_3246	COG1404	Belongs to the peptidase S8 family
BEST7613_3248	COG1191	sigma factor activity
BEST7613_3249	COG1191	sigma factor activity
BEST7613_3250	COG1119	ATPase activity
BEST7613_3251	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7613_3252	COG1873	PFAM PRC-barrel domain
BEST7613_3254	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BEST7613_3255	COG1799	cell septum assembly
BEST7613_3256	COG0762	integral membrane protein
BEST7613_3257	COG2302	S4 RNA-binding domain
BEST7613_3258	COG3599	regulation of cell shape
BEST7613_3259	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BEST7613_3260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7613_3261	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BEST7613_3262	COG0564	pseudouridine synthase activity
BEST7613_3263	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BEST7613_3264	COG2233	PERMEase
BEST7613_3265	COG0540	Belongs to the ATCase OTCase family
BEST7613_3266	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BEST7613_3267	COG0505	Belongs to the CarA family
BEST7613_3268	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7613_3269	COG0543	2 iron, 2 sulfur cluster binding
BEST7613_3270	COG0167	dihydroorotate dehydrogenase activity
BEST7613_3271	COG0284	orotidine-5'-phosphate decarboxylase activity
BEST7613_3272	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BEST7613_3273	COG0175	sulfate reduction
BEST7613_3274	COG0306	phosphate transporter
BEST7613_3275	COG2046	Belongs to the sulfate adenylyltransferase family
BEST7613_3276	COG0529	Catalyzes the synthesis of activated sulfate
BEST7613_3277	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BEST7613_3278	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BEST7613_3279	COG1648	precorrin-2 dehydrogenase activity
BEST7613_3281	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7613_3282	COG1561	YicC-like family, N-terminal region
BEST7613_3283	COG2052	Domain of unknown function (DUF370)
BEST7613_3284	COG0194	GDP metabolic process
BEST7613_3285	COG1758	RNA polymerase activity
BEST7613_3286	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BEST7613_3287	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BEST7613_3288	COG0242	peptide deformylase activity
BEST7613_3289	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BEST7613_3290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7613_3290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BEST7613_3291	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BEST7613_3292	COG0631	protein serine/threonine phosphatase activity
BEST7613_3293	COG0515	serine threonine protein kinase
BEST7613_3293	COG2815	serine threonine protein kinase
BEST7613_3294	COG1162	GTPase activity
BEST7613_3295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BEST7613_3296	COG1564	THIamine pyrophosphokinase
BEST7613_3297	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BEST7613_3298	COG1302	Protein conserved in bacteria
BEST7613_3299	COG1461	Dihydroxyacetone kinase
BEST7613_3300	COG1760	l-serine dehydratase
BEST7613_3301	COG1760	l-serine dehydratase
BEST7613_3302	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BEST7613_3303	COG1349	DNA-binding transcription factor activity
BEST7613_3303	COG2050	protein possibly involved in aromatic compounds catabolism
BEST7613_3304	COG0416	fatty acid biosynthetic process
BEST7613_3305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7613_3306	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3307	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7613_3308	COG0571	ribonuclease III activity
BEST7613_3309	COG1196	nuclear chromosome segregation
BEST7613_3310	COG0552	protein localization to endoplasmic reticulum
BEST7613_3312	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BEST7613_3313	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BEST7613_3314	COG0228	four-way junction DNA binding
BEST7613_3315	COG1837	Belongs to the UPF0109 family
BEST7613_3317	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BEST7613_3318	COG0336	Belongs to the RNA methyltransferase TrmD family
BEST7613_3319	COG0335	large ribosomal subunit rRNA binding
BEST7613_3320	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BEST7613_3321	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BEST7613_3323	COG2257	FlhB HrpN YscU SpaS Family
BEST7613_3324	COG0045	succinate-CoA ligase (ADP-forming) activity
BEST7613_3325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BEST7613_3326	COG0758	DNA mediated transformation
BEST7613_3327	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BEST7613_3328	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BEST7613_3329	COG4974	Belongs to the 'phage' integrase family
BEST7613_3330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BEST7613_3331	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BEST7613_3332	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BEST7613_3333	COG1815	bacterial-type flagellum-dependent cell motility
BEST7613_3334	COG1558	bacterial-type flagellum-dependent cell motility
BEST7613_3335	COG1677	Flagellar hook-basal body complex protein FliE
BEST7613_3336	COG1766	The M ring may be actively involved in energy transduction
BEST7613_3337	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7613_3338	COG1317	bacterial-type flagellum organization
BEST7613_3339	COG1157	protein secretion by the type III secretion system
BEST7613_3340	COG2882	bacterial-type flagellum organization
BEST7613_3341	COG3334	PFAM MgtE intracellular
BEST7613_3342	COG3144	bacterial-type flagellum assembly
BEST7613_3343	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BEST7613_3344	COG4786	Flagellar basal body rod
BEST7613_3345	COG1582	Flagellar protein (FlbD)
BEST7613_3346	COG1580	Controls the rotational direction of flagella during chemotaxis
BEST7613_3347	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7613_3348	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BEST7613_3348	COG1776	CheC inhibitor of MCP methylation
BEST7613_3349	COG2201	protein-glutamate methylesterase activity
BEST7613_3350	COG3190	flagellar
BEST7613_3351	COG1338	Plays a role in the flagellum-specific transport system
BEST7613_3352	COG1987	bacterial-type flagellum assembly
BEST7613_3353	COG1684	flagellar biosynthetic protein fliR
BEST7613_3354	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BEST7613_3355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BEST7613_3356	COG1419	protein localization to endoplasmic reticulum
BEST7613_3357	COG0455	bacterial-type flagellum organization
BEST7613_3358	COG2201	protein-glutamate methylesterase activity
BEST7613_3359	COG2198	Histidine kinase
BEST7613_3359	COG0643	Histidine kinase
BEST7613_3360	COG0835	chemotaxis
BEST7613_3361	COG1776	CheC inhibitor of MCP methylation
BEST7613_3362	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BEST7613_3363	COG1191	sigma factor activity
BEST7613_3365	COG0052	Belongs to the universal ribosomal protein uS2 family
BEST7613_3366	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BEST7613_3367	COG0528	UMP kinase activity
BEST7613_3368	COG0233	cytoplasmic translational termination
BEST7613_3369	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BEST7613_3370	COG4589	Belongs to the CDS family
BEST7613_3371	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BEST7613_3372	COG0750	zinc metalloprotease
BEST7613_3373	COG0442	prolyl-tRNA aminoacylation
BEST7613_3374	COG2176	DNA-directed DNA polymerase activity
BEST7613_3375	COG0779	Required for maturation of 30S ribosomal subunits
BEST7613_3376	COG0195	Participates in both transcription termination and antitermination
BEST7613_3377	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BEST7613_3378	COG1358	cellular component organization or biogenesis
BEST7613_3379	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BEST7613_3380	COG1550	Protein conserved in bacteria
BEST7613_3381	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BEST7613_3382	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BEST7613_3383	COG0196	riboflavin kinase activity
BEST7613_3384	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BEST7613_3385	COG1185	polyribonucleotide nucleotidyltransferase activity
BEST7613_3386	COG0726	polysaccharide deacetylase
BEST7613_3387	COG0612	Peptidase, M16
BEST7613_3388	COG1873	PFAM PRC-barrel domain
BEST7613_3389	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BEST7613_3390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BEST7613_3391	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BEST7613_3392	COG0527	aspartate kinase activity
BEST7613_3393	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BEST7613_3394	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BEST7613_3395	COG0740	serine-type endopeptidase activity
BEST7613_3397	COG1674	ftsk spoiiie
BEST7613_3397	COG4980	gas vesicle protein
BEST7613_3398	COG2188	Transcriptional regulator
BEST7613_3399	COG2814	Major facilitator Superfamily
BEST7613_3400	COG0612	Peptidase, M16
BEST7613_3401	COG0612	Peptidase, M16
BEST7613_3402	COG0300	oxidoreductase activity
BEST7613_3406	COG1426	Protein conserved in bacteria
BEST7613_3407	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BEST7613_3408	COG1058	Belongs to the CinA family
BEST7613_3408	COG1546	Belongs to the CinA family
BEST7613_3409	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BEST7613_3410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7613_3411	COG1418	mRNA catabolic process
BEST7613_3412	COG1692	metallophosphoesterase
BEST7613_3413	COG2359	stage V sporulation protein S
BEST7613_3414	COG1063	alcohol dehydrogenase
BEST7613_3415	COG0156	8-amino-7-oxononanoate synthase activity
BEST7613_3416	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7613_3417	COG4550	Control of competence regulator ComK, YlbF/YmcA
BEST7613_3419	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BEST7613_3420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BEST7613_3423	COG3226	Transcriptional regulator
BEST7613_3424	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_3425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7613_3426	COG3321	synthase
BEST7613_3427	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BEST7613_3427	COG2070	2-Nitropropane dioxygenase
BEST7613_3428	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7613_3429	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BEST7613_3430	COG3425	synthase
BEST7613_3431	COG1024	Enoyl-CoA hydratase
BEST7613_3432	COG1024	Enoyl-CoA hydratase
BEST7613_3433	COG3321	synthase
BEST7613_3433	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_3433	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3433	COG0300	oxidoreductase activity
BEST7613_3433	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3434	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7613_3434	COG4221	oxidoreductase activity
BEST7613_3434	COG0300	oxidoreductase activity
BEST7613_3434	COG3321	synthase
BEST7613_3435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7613_3435	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7613_3435	COG3321	synthase
BEST7613_3436	COG4221	oxidoreductase activity
BEST7613_3436	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3436	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3436	COG3321	synthase
BEST7613_3437	COG3321	synthase
BEST7613_3437	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3437	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3437	COG4221	oxidoreductase activity
BEST7613_3438	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7613_3438	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BEST7613_3438	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BEST7613_3438	COG3321	synthase
BEST7613_3439	COG2124	cytochrome p450
BEST7613_3441	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_3442	COG1404	Belongs to the peptidase S8 family
BEST7613_3443	COG4195	phage-related replication protein
BEST7613_3444	COG1764	response to oxidative stress
BEST7613_3445	COG2076	Multidrug Resistance protein
BEST7613_3446	COG2076	Multidrug Resistance protein
BEST7613_3449	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BEST7613_3450	COG1923	regulation of RNA biosynthetic process
BEST7613_3453	COG1780	Probably involved in ribonucleotide reductase function
BEST7613_3454	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7613_3455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7613_3456	COG4112	unkown
BEST7613_3457	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7613_3458	COG0464	growth
BEST7613_3459	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BEST7613_3460	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BEST7613_3461	COG0789	Transcriptional regulator
BEST7613_3462	COG0174	glutamine synthetase
BEST7613_3466	COG4282	regulation of fungal-type cell wall biogenesis
BEST7613_3468	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_3473	COG0135	phosphoribosylanthranilate isomerase activity
BEST7613_3474	COG2211	Major facilitator Superfamily
BEST7613_3475	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7613_3476	COG1940	carbohydrate kinase activity
BEST7613_3477	COG2115	Belongs to the xylose isomerase family
BEST7613_3478	COG1070	Carbohydrate kinase
BEST7613_3479	COG1525	nuclease
BEST7613_3480	COG2814	Major facilitator Superfamily
BEST7613_3481	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BEST7613_3483	COG0756	dUTP diphosphatase activity
BEST7613_3487	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BEST7613_3492	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BEST7613_3494	COG3832	glyoxalase III activity
BEST7613_3496	COG0697	spore germination
BEST7613_3497	COG0531	amino acid
BEST7613_3503	COG4195	phage-related replication protein
BEST7613_3505	COG0346	lactoylglutathione lyase activity
BEST7613_3506	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BEST7613_3507	COG1388	LysM domain
BEST7613_3508	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BEST7613_3509	COG4224	UPF0291 protein
BEST7613_3510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BEST7613_3512	COG3763	UPF0154 protein
BEST7613_3514	COG0785	Cytochrome C biogenesis protein
BEST7613_3515	COG2201	protein-glutamate methylesterase activity
BEST7613_3516	COG4846	Membrane protein involved in cytochrome C biogenesis
BEST7613_3518	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7613_3521	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BEST7613_3522	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_3526	COG0824	Thioesterase
BEST7613_3528	COG4841	protein insertion into membrane
BEST7613_3529	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BEST7613_3530	COG1832	CoA-binding protein
BEST7613_3531	COG0187	DNA topoisomerase II activity
BEST7613_3532	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7613_3535	COG1115	amino acid carrier protein
BEST7613_3538	COG5520	Belongs to the glycosyl hydrolase 30 family
BEST7613_3539	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7613_3540	COG2246	polysaccharide biosynthetic process
BEST7613_3541	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7613_3542	COG0586	Pfam SNARE associated Golgi protein
BEST7613_3543	COG2404	hydrolase activity, acting on ester bonds
BEST7613_3544	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BEST7613_3545	COG1024	Enoyl-CoA hydratase
BEST7613_3546	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7613_3547	COG0511	ligase activity, forming carbon-carbon bonds
BEST7613_3548	COG0439	Biotin carboxylase
BEST7613_3549	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_3550	COG1960	acyl-CoA dehydrogenase activity
BEST7613_3552	COG1649	PFAM Uncharacterised BCR, COG1649
BEST7613_3554	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3554	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BEST7613_3555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3556	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3557	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_3558	COG2027	D-alanyl-D-alanine carboxypeptidase
BEST7613_3559	COG2017	converts alpha-aldose to the beta-anomer
BEST7613_3560	COG0534	Mate efflux family protein
BEST7613_3562	COG0582	viral genome integration into host DNA
BEST7613_3563	COG0166	Belongs to the GPI family
BEST7613_3564	COG0405	Gamma-glutamyltransferase
BEST7613_3565	COG0583	DNA-binding transcription factor activity
BEST7613_3566	COG0604	alcohol dehydrogenase
BEST7613_3567	COG0493	'glutamate synthase
BEST7613_3568	COG0069	glutamate synthase activity
BEST7613_3568	COG0070	glutamate synthase
BEST7613_3568	COG0067	glutamate synthase
BEST7613_3569	COG0583	DNA-binding transcription factor activity
BEST7613_3570	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BEST7613_3571	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7613_3573	COG0300	oxidoreductase activity
BEST7613_3574	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BEST7613_3576	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BEST7613_3577	COG2814	Major facilitator Superfamily
BEST7613_3578	COG1070	Carbohydrate kinase
BEST7613_3579	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BEST7613_3580	COG0243	molybdopterin cofactor binding
BEST7613_3585	COG0840	transmembrane signaling receptor activity
BEST7613_3585	COG5278	phosphoserine phosphatase activity
BEST7613_3586	COG5278	phosphoserine phosphatase activity
BEST7613_3586	COG0840	transmembrane signaling receptor activity
BEST7613_3587	COG2368	4-hydroxyphenylacetate
BEST7613_3588	COG4305	rare lipoprotein A
BEST7613_3589	COG3619	membrane
BEST7613_3590	COG3866	Pectate lyase
BEST7613_3591	COG2135	peptidase activity
BEST7613_3593	COG2140	Oxalate decarboxylase
BEST7613_3595	COG0456	acetyltransferase
BEST7613_3598	COG2720	vancomycin resistance protein
BEST7613_3600	COG3655	Transcriptional regulator
BEST7613_3601	COG3739	integral membrane protein
BEST7613_3602	COG0583	DNA-binding transcription factor activity
BEST7613_3603	COG0697	spore germination
BEST7613_3605	COG0693	protein deglycase activity
BEST7613_3606	COG2367	Beta-lactamase
BEST7613_3610	COG3848	Pyruvate phosphate dikinase
BEST7613_3610	COG0574	Belongs to the PEP-utilizing enzyme family
BEST7613_3611	COG0726	polysaccharide deacetylase
BEST7613_3612	COG2314	TM2 domain
BEST7613_3613	COG1396	sequence-specific DNA binding
BEST7613_3616	COG2135	peptidase activity
BEST7613_3622	COG0457	Tetratricopeptide repeat
BEST7613_3624	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7613_3625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7613_3628	COG5290	Psort location Cytoplasmic, score
BEST7613_3632	COG5444	nuclease activity
BEST7613_3633	COG4282	regulation of fungal-type cell wall biogenesis
BEST7613_3634	COG1231	oxidoreductase activity
BEST7613_3635	COG5434	Belongs to the glycosyl hydrolase 28 family
BEST7613_3636	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7613_3637	COG0662	Cupin 2, conserved barrel domain protein
BEST7613_3637	COG2207	Transcriptional regulator
BEST7613_3638	COG0456	acetyltransferase
BEST7613_3639	COG1309	transcriptional regulator
BEST7613_3640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_3641	COG3708	Transcriptional regulator
BEST7613_3642	COG2378	regulation of single-species biofilm formation
BEST7613_3644	COG0640	Transcriptional regulator
BEST7613_3645	COG0741	lytic transglycosylase activity
BEST7613_3646	COG2322	membrane
BEST7613_3649	COG1619	proteins homologs of microcin C7 resistance protein MccF
BEST7613_3650	COG3239	Fatty acid desaturase
BEST7613_3651	COG4585	Histidine kinase
BEST7613_3652	COG2197	response regulator
BEST7613_3653	COG3584	3D domain protein
BEST7613_3653	COG1388	LysM domain
BEST7613_3654	COG0514	ATP-dependent DNA helicase (RecQ)
BEST7613_3655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BEST7613_3656	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7613_3659	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7613_3664	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_3665	COG1657	PFAM Prenyltransferase squalene oxidase
BEST7613_3666	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BEST7613_3667	COG0733	neurotransmitter:sodium symporter activity
BEST7613_3668	COG0385	Bile acid
BEST7613_3669	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7613_3670	COG0567	Dehydrogenase, E1 component
BEST7613_3671	COG4548	von Willebrand factor, type A
BEST7613_3672	COG0714	Associated with various cellular activities
BEST7613_3673	COG2032	superoxide dismutase activity
BEST7613_3674	COG1388	LysM domain
BEST7613_3674	COG0791	NLP P60 protein
BEST7613_3675	COG1819	glycosyl
BEST7613_3676	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BEST7613_3677	COG0534	Mate efflux family protein
BEST7613_3678	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_3679	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7613_3680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7613_3682	COG2962	Rard protein
BEST7613_3685	COG2610	gluconate transmembrane transporter activity
BEST7613_3686	COG1942	4-Oxalocrotonate Tautomerase
BEST7613_3687	COG1733	regulation of RNA biosynthetic process
BEST7613_3688	COG0778	Nitroreductase
BEST7613_3689	COG0400	carboxylic ester hydrolase activity
BEST7613_3690	COG0346	lactoylglutathione lyase activity
BEST7613_3692	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7613_3693	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_3693	COG0793	Belongs to the peptidase S41A family
BEST7613_3694	COG2226	methyltransferase
BEST7613_3696	COG1876	peptidase activity
BEST7613_3697	COG0813	purine-nucleoside phosphorylase activity
BEST7613_3700	COG0671	phosphoesterase, PA-phosphatase related
BEST7613_3704	COG4479	Belongs to the UPF0346 family
BEST7613_3706	COG1509	lysine 2,3-aminomutase activity
BEST7613_3707	COG0456	acetyltransferase
BEST7613_3708	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7613_3709	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BEST7613_3710	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BEST7613_3711	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7613_3712	COG0456	acetyltransferase
BEST7613_3713	COG0463	Glycosyl transferase, family 2
BEST7613_3716	COG4641	Protein conserved in bacteria
BEST7613_3717	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
BEST7613_3718	COG1086	Polysaccharide biosynthesis protein
BEST7613_3719	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7613_3720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BEST7613_3721	COG1846	Transcriptional regulator
BEST7613_3722	COG0534	Mate efflux family protein
BEST7613_3724	COG4698	Protein conserved in bacteria
BEST7613_3725	COG2755	lipolytic protein G-D-S-L family
BEST7613_3726	COG1999	signal sequence binding
BEST7613_3728	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BEST7613_3729	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BEST7613_3730	COG1272	protein, Hemolysin III
BEST7613_3731	COG0204	Acyl-transferase
BEST7613_3732	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7613_3733	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BEST7613_3734	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BEST7613_3736	COG2521	methyltransferase
BEST7613_3736	COG2136	Putative SAM-dependent methyltransferase
BEST7613_3738	COG0129	dihydroxy-acid dehydratase activity
BEST7613_3739	COG1413	lyase activity
BEST7613_3740	COG1418	mRNA catabolic process
BEST7613_3741	COG0386	Belongs to the glutathione peroxidase family
BEST7613_3742	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BEST7613_3743	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7613_3744	COG1278	Cold shock
BEST7613_3748	COG0328	RNA-DNA hybrid ribonuclease activity
BEST7613_3749	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BEST7613_3750	COG0328	RNA-DNA hybrid ribonuclease activity
BEST7613_3752	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7613_3755	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BEST7613_3756	COG1755	Isoprenylcysteine carboxyl methyltransferase
BEST7613_3757	COG3424	synthase
BEST7613_3758	COG2233	PERMEase
BEST7613_3759	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7613_3760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BEST7613_3762	COG0800	Aldolase
BEST7613_3763	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7613_3764	COG1609	Transcriptional regulator
BEST7613_3765	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BEST7613_3766	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_3767	COG1199	ATP-dependent helicase activity
BEST7613_3769	COG0116	Belongs to the methyltransferase superfamily
BEST7613_3771	COG4474	Belongs to the UPF0398 family
BEST7613_3772	COG3359	exonuclease
BEST7613_3773	COG1111	helicase
BEST7613_3773	COG1205	dead DEAH box helicase
BEST7613_3774	COG2190	(PTS) system
BEST7613_3775	COG0071	Belongs to the small heat shock protein (HSP20) family
BEST7613_3781	COG3331	DNA recombination
BEST7613_3782	COG4499	WXG100 protein secretion system (Wss), protein YukC
BEST7613_3782	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7613_3784	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BEST7613_3785	COG3935	DnaD domain protein
BEST7613_3786	COG0017	Asparaginyl-tRNA synthetase
BEST7613_3787	COG0436	Aminotransferase
BEST7613_3788	COG5353	protein conserved in bacteria
BEST7613_3790	COG1199	ATP-dependent helicase activity
BEST7613_3790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BEST7613_3791	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BEST7613_3792	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BEST7613_3793	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BEST7613_3794	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BEST7613_3794	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BEST7613_3795	COG0617	tRNA 3'-terminal CCA addition
BEST7613_3796	COG0438	transferase activity, transferring glycosyl groups
BEST7613_3797	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BEST7613_3798	COG1803	Methylglyoxal synthase
BEST7613_3799	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BEST7613_3800	COG1694	Mazg nucleotide pyrophosphohydrolase
BEST7613_3801	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7613_3803	COG4347	Protein of unknown function (DUF1405)
BEST7613_3804	COG2010	Cytochrome c
BEST7613_3804	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7613_3805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7613_3806	COG0723	plastoquinol--plastocyanin reductase activity
BEST7613_3808	COG5582	Belongs to the UPF0302 family
BEST7613_3809	COG0457	Tetratricopeptide repeat
BEST7613_3810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BEST7613_3811	COG0287	Prephenate dehydrogenase
BEST7613_3812	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BEST7613_3813	COG0159	tryptophan synthase activity
BEST7613_3814	COG0133	tryptophan synthase activity
BEST7613_3815	COG0135	phosphoribosylanthranilate isomerase activity
BEST7613_3817	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BEST7613_3818	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7613_3819	COG4401	Chorismate mutase type I
BEST7613_3820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BEST7613_3821	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BEST7613_3822	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BEST7613_3823	COG0105	UTP biosynthetic process
BEST7613_3824	COG0142	geranyltranstransferase activity
BEST7613_3825	COG2226	methyltransferase
BEST7613_3826	COG0142	geranyltranstransferase activity
BEST7613_3828	COG0302	gtp cyclohydrolase
BEST7613_3829	COG0776	regulation of translation
BEST7613_3830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BEST7613_3833	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BEST7613_3834	COG1160	GTP binding
BEST7613_3839	COG1304	FMN binding
BEST7613_3840	COG0539	negative regulation of cytoplasmic translation
BEST7613_3841	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BEST7613_3843	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BEST7613_3844	COG2959	enzyme of heme biosynthesis
BEST7613_3845	COG2959	enzyme of heme biosynthesis
BEST7613_3846	COG3773	Cell wall hydrolase
BEST7613_3846	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_3847	COG2339	peptidase activity
BEST7613_3848	COG0492	ferredoxin-NADP+ reductase activity
BEST7613_3849	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7613_3850	COG4862	establishment of competence for transformation
BEST7613_3851	COG1408	metallophosphoesterase
BEST7613_3852	COG1388	LysM domain
BEST7613_3853	COG1266	CAAX protease self-immunity
BEST7613_3854	COG0514	ATP-dependent DNA helicase (RecQ)
BEST7613_3855	COG4955	Helix-turn-helix domain
BEST7613_3856	COG1141	Ferredoxin
BEST7613_3857	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BEST7613_3859	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BEST7613_3860	COG0710	3-dehydroquinate dehydratase activity
BEST7613_3862	COG1595	DNA-templated transcription, initiation
BEST7613_3863	COG5002	protein histidine kinase activity
BEST7613_3864	COG0745	RESPONSE REGULATOR receiver
BEST7613_3865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BEST7613_3866	COG1333	cytochrome c biogenesis protein
BEST7613_3867	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_3868	COG1187	pseudouridine synthase activity
BEST7613_3869	COG0700	Nucleoside recognition
BEST7613_3870	COG2715	membrane protein required for spore maturation
BEST7613_3871	COG1686	Belongs to the peptidase S11 family
BEST7613_3873	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BEST7613_3874	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BEST7613_3875	COG1547	Domain of unknown function (DUF309)
BEST7613_3876	COG0456	acetyltransferase
BEST7613_3877	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BEST7613_3878	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7613_3878	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7613_3879	COG0307	riboflavin synthase, alpha
BEST7613_3880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7613_3880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7613_3882	COG0681	Belongs to the peptidase S26 family
BEST7613_3884	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
BEST7613_3887	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BEST7613_3888	COG4086	secreted protein
BEST7613_3889	COG0019	diaminopimelate decarboxylase activity
BEST7613_3890	COG0697	spore germination
BEST7613_3893	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BEST7613_3897	COG1191	sigma factor activity
BEST7613_3898	COG2172	sigma factor antagonist activity
BEST7613_3899	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_3900	COG1686	Belongs to the peptidase S11 family
BEST7613_3901	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BEST7613_3902	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BEST7613_3903	COG4974	Belongs to the 'phage' integrase family
BEST7613_3905	COG0735	belongs to the Fur family
BEST7613_3906	COG1300	Membrane
BEST7613_3908	COG0281	malic enzyme
BEST7613_3909	COG1757	Na H antiporter
BEST7613_3910	COG1027	Aspartate ammonia-lyase
BEST7613_3911	COG0252	asparaginase activity
BEST7613_3912	COG1396	sequence-specific DNA binding
BEST7613_3913	COG1379	DNA repair
BEST7613_3914	COG0494	nUDIX hydrolase
BEST7613_3916	COG0667	Aldo Keto reductase
BEST7613_3918	COG1073	alpha beta
BEST7613_3920	COG4918	Iron-sulphur cluster biosynthesis
BEST7613_3921	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BEST7613_3921	COG0456	acetyltransferase
BEST7613_3922	COG2329	Antibiotic biosynthesis monooxygenase
BEST7613_3923	COG0456	acetyltransferase
BEST7613_3925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7613_3927	COG2211	Major facilitator Superfamily
BEST7613_3929	COG0346	lactoylglutathione lyase activity
BEST7613_3930	COG1072	(Pantothenic acid kinase))
BEST7613_3931	COG3048	D-serine ammonia-lyase activity
BEST7613_3932	COG0300	oxidoreductase activity
BEST7613_3933	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_3934	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7613_3935	COG4187	Peptidase family M20/M25/M40
BEST7613_3936	COG1902	pentaerythritol trinitrate reductase activity
BEST7613_3937	COG0596	Alpha beta hydrolase
BEST7613_3938	COG1234	tRNA 3'-trailer cleavage
BEST7613_3939	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BEST7613_3940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BEST7613_3941	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7613_3943	COG0706	membrane insertase activity
BEST7613_3944	COG3361	conserved protein (COG2071)
BEST7613_3945	COG2195	Cleaves the N-terminal amino acid of tripeptides
BEST7613_3946	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BEST7613_3947	COG0346	lactoylglutathione lyase activity
BEST7613_3948	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7613_3949	COG4129	membrane
BEST7613_3950	COG1126	abc transporter atp-binding protein
BEST7613_3951	COG0765	amino acid transport
BEST7613_3952	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_3954	COG1597	lipid kinase activity
BEST7613_3955	COG2814	Major facilitator Superfamily
BEST7613_3956	COG0789	Transcriptional regulator
BEST7613_3956	COG4978	Transcriptional regulator
BEST7613_3957	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7613_3958	COG0022	dehydrogenase e1 component
BEST7613_3959	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7613_3960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BEST7613_3961	COG3426	butyrate kinase activity
BEST7613_3962	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7613_3963	COG0280	phosphate acetyltransferase
BEST7613_3964	COG3829	transcription factor binding
BEST7613_3964	COG3290	protein histidine kinase activity
BEST7613_3966	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BEST7613_3967	COG2079	MmgE PrpD family protein
BEST7613_3968	COG0372	Belongs to the citrate synthase family
BEST7613_3969	COG1960	acyl-CoA dehydrogenase activity
BEST7613_3970	COG1250	3-hydroxyacyl-CoA dehydrogenase
BEST7613_3971	COG0183	Belongs to the thiolase family
BEST7613_3972	COG0584	glycerophosphoryl diester phosphodiesterase
BEST7613_3973	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7613_3975	COG1902	pentaerythritol trinitrate reductase activity
BEST7613_3976	COG0745	RESPONSE REGULATOR receiver
BEST7613_3977	COG0750	zinc metalloprotease
BEST7613_3978	COG0497	DNA recombination
BEST7613_3979	COG1438	arginine binding
BEST7613_3980	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BEST7613_3981	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BEST7613_3982	COG0142	geranyltranstransferase activity
BEST7613_3983	COG1722	exodeoxyribonuclease VII activity
BEST7613_3984	COG1570	exodeoxyribonuclease VII activity
BEST7613_3985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BEST7613_3986	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7613_3987	COG1302	Protein conserved in bacteria
BEST7613_3988	COG0439	Biotin carboxylase
BEST7613_3989	COG0511	ligase activity, forming carbon-carbon bonds
BEST7613_3997	COG3854	ATPases associated with a variety of cellular activities
BEST7613_3999	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BEST7613_4000	COG0006	proline dipeptidase activity
BEST7613_4001	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BEST7613_4003	COG3872	metal-dependent enzyme
BEST7613_4005	COG1752	Esterase of the alpha-beta hydrolase superfamily
BEST7613_4006	COG1321	iron dependent repressor
BEST7613_4007	COG0095	Lipoate-protein ligase
BEST7613_4008	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7613_4009	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7613_4010	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7613_4011	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BEST7613_4012	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BEST7613_4015	COG1396	sequence-specific DNA binding
BEST7613_4017	COG0681	Belongs to the peptidase S26 family
BEST7613_4023	COG4940	Competence protein ComGF
BEST7613_4025	COG4970	Tfp pilus assembly protein FimT
BEST7613_4026	COG4537	Required for transformation and DNA binding
BEST7613_4027	COG1459	type II secretion system
BEST7613_4028	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BEST7613_4029	COG0598	Magnesium transport protein CorA
BEST7613_4030	COG1253	flavin adenine dinucleotide binding
BEST7613_4031	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_4032	COG1393	Belongs to the ArsC family
BEST7613_4034	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_4036	COG0011	TIGRFAM Protein of
BEST7613_4038	COG2866	Carboxypeptidase
BEST7613_4039	COG1368	sulfuric ester hydrolase activity
BEST7613_4040	COG1940	carbohydrate kinase activity
BEST7613_4041	COG4483	Protein conserved in bacteria
BEST7613_4042	COG0457	Tetratricopeptide repeat
BEST7613_4042	COG0705	Rhomboid family
BEST7613_4044	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BEST7613_4045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BEST7613_4046	COG0438	transferase activity, transferring glycosyl groups
BEST7613_4049	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BEST7613_4050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7613_4051	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7613_4052	COG0581	inorganic phosphate transmembrane transporter activity
BEST7613_4053	COG0573	inorganic phosphate transmembrane transporter activity
BEST7613_4054	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7613_4056	COG0477	Major facilitator Superfamily
BEST7613_4057	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BEST7613_4058	COG2839	Protein conserved in bacteria
BEST7613_4059	COG5521	maltodextrose utilization protein MalA
BEST7613_4061	COG1388	LysM domain
BEST7613_4062	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BEST7613_4063	COG4709	membrane
BEST7613_4064	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BEST7613_4065	COG0735	belongs to the Fur family
BEST7613_4066	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7613_4068	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BEST7613_4069	COG0513	Belongs to the DEAD box helicase family
BEST7613_4071	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BEST7613_4072	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BEST7613_4073	COG2384	SAM-dependent methyltransferase
BEST7613_4074	COG2010	Cytochrome c
BEST7613_4075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7613_4076	COG0358	DNA primase activity
BEST7613_4077	COG1671	Belongs to the UPF0178 family
BEST7613_4078	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BEST7613_4079	COG0517	IMP dehydrogenase activity
BEST7613_4080	COG0751	glycine-tRNA ligase activity
BEST7613_4081	COG0752	glycyl-tRNA synthetase alpha subunit
BEST7613_4082	COG1381	Involved in DNA repair and RecF pathway recombination
BEST7613_4084	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BEST7613_4085	COG0295	cytidine deaminase activity
BEST7613_4086	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BEST7613_4087	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BEST7613_4088	COG1480	7TM receptor with intracellular HD hydrolase
BEST7613_4089	COG1702	phosphate starvation-inducible protein PhoH
BEST7613_4090	COG0561	phosphatase activity
BEST7613_4093	COG4864	UPF0365 protein
BEST7613_4094	COG1030	water channel activity
BEST7613_4095	COG1610	YqeY-like protein
BEST7613_4096	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BEST7613_4097	COG1283	sodium-dependent phosphate transmembrane transporter activity
BEST7613_4098	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7613_4099	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BEST7613_4100	COG2264	protein methyltransferase activity
BEST7613_4101	COG0484	heat shock protein binding
BEST7613_4102	COG0443	Heat shock 70 kDa protein
BEST7613_4103	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BEST7613_4104	COG1420	regulation of RNA biosynthetic process
BEST7613_4105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7613_4106	COG0481	GTPase activity
BEST7613_4108	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7613_4109	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BEST7613_4111	COG0268	Binds directly to 16S ribosomal RNA
BEST7613_4112	COG1466	dna polymerase III delta subunit
BEST7613_4114	COG0658	competence protein
BEST7613_4114	COG2333	competence protein COMEC
BEST7613_4115	COG2131	deaminase
BEST7613_4116	COG1555	photosystem II stabilization
BEST7613_4116	COG1596	polysaccharide export
BEST7613_4117	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7613_4118	COG2226	methyltransferase
BEST7613_4119	COG0799	negative regulation of ribosome biogenesis
BEST7613_4120	COG1713	HD superfamily hydrolase involved in NAD metabolism
BEST7613_4121	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BEST7613_4122	COG1534	Rna-binding protein
BEST7613_4123	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BEST7613_4124	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BEST7613_4125	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BEST7613_4126	COG2755	lipolytic protein G-D-S-L family
BEST7613_4127	COG5632	N-Acetylmuramoyl-L-alanine amidase
BEST7613_4127	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_4128	COG0398	Pfam SNARE associated Golgi protein
BEST7613_4129	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BEST7613_4131	COG3209	COG3209 Rhs family protein
BEST7613_4134	COG3223	Belongs to the PsiE family
BEST7613_4135	COG0642	Histidine kinase
BEST7613_4135	COG5002	protein histidine kinase activity
BEST7613_4136	COG0745	RESPONSE REGULATOR receiver
BEST7613_4137	COG2311	Membrane
BEST7613_4138	COG0454	-acetyltransferase
BEST7613_4139	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7613_4141	COG0730	response to heat
BEST7613_4142	COG0425	Belongs to the sulfur carrier protein TusA family
BEST7613_4143	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7613_4143	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_4144	COG0425	Belongs to the sulfur carrier protein TusA family
BEST7613_4144	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7613_4145	COG2210	Belongs to the sulfur carrier protein TusA family
BEST7613_4146	COG1937	Protein conserved in bacteria
BEST7613_4149	COG0662	Cupin 2, conserved barrel domain protein
BEST7613_4151	COG0789	Transcriptional regulator
BEST7613_4151	COG4978	Transcriptional regulator
BEST7613_4152	COG2814	Major facilitator Superfamily
BEST7613_4153	COG0456	acetyltransferase
BEST7613_4154	COG1253	flavin adenine dinucleotide binding
BEST7613_4156	COG0697	spore germination
BEST7613_4157	COG0583	DNA-binding transcription factor activity
BEST7613_4158	COG2072	flavoprotein involved in K transport
BEST7613_4159	COG1230	cation diffusion facilitator family transporter
BEST7613_4160	COG1942	4-Oxalocrotonate Tautomerase
BEST7613_4161	COG0583	DNA-binding transcription factor activity
BEST7613_4163	COG1114	Component of the transport system for branched-chain amino acids
BEST7613_4164	COG1687	branched-chain amino acid
BEST7613_4165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BEST7613_4166	COG1522	sequence-specific DNA binding
BEST7613_4167	COG2732	(Barnase) inhibitor
BEST7613_4168	COG2124	cytochrome p450
BEST7613_4171	COG1335	isochorismatase
BEST7613_4173	COG2318	DinB family
BEST7613_4175	COG2070	2-Nitropropane dioxygenase
BEST7613_4178	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BEST7613_4181	COG3443	Belongs to the bacterial solute-binding protein 9 family
BEST7613_4182	COG1595	DNA-templated transcription, initiation
BEST7613_4183	COG0667	Aldo Keto reductase
BEST7613_4184	COG2851	Citrate transporter
BEST7613_4185	COG0583	DNA-binding transcription factor activity
BEST7613_4186	COG2828	Protein conserved in bacteria
BEST7613_4188	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_4189	COG5566	PFAM Mor transcription activator
BEST7613_4190	COG0596	Alpha beta hydrolase
BEST7613_4191	COG4991	sh3 domain protein
BEST7613_4192	COG4991	sh3 domain protein
BEST7613_4193	COG0346	lactoylglutathione lyase activity
BEST7613_4195	COG5577	PFAM Coat F domain
BEST7613_4196	COG1063	alcohol dehydrogenase
BEST7613_4198	COG5577	PFAM Coat F domain
BEST7613_4199	COG0789	Transcriptional regulator
BEST7613_4201	COG1064	alcohol dehydrogenase
BEST7613_4202	COG0693	protein deglycase activity
BEST7613_4203	COG1621	beta-fructofuranosidase activity
BEST7613_4204	COG3716	PTS system mannose fructose sorbose family IID component
BEST7613_4205	COG3715	PTS system
BEST7613_4206	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_4207	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_4208	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BEST7613_4208	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BEST7613_4209	COG1113	amino acid transport
BEST7613_4210	COG1280	lysine exporter protein (LysE YggA)
BEST7613_4211	COG1378	Sugar-specific transcriptional regulator TrmB
BEST7613_4212	COG1595	DNA-templated transcription, initiation
BEST7613_4214	COG2755	lipolytic protein G-D-S-L family
BEST7613_4214	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BEST7613_4216	COG2124	cytochrome p450
BEST7613_4216	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7613_4217	COG1309	transcriptional regulator
BEST7613_4218	COG2226	methyltransferase
BEST7613_4220	COG2116	formate transmembrane transporter activity
BEST7613_4221	COG5609	conserved protein (DUF2294)
BEST7613_4222	COG3383	formate dehydrogenase (NAD+) activity
BEST7613_4223	COG2427	Protein of unknown function (DUF1641)
BEST7613_4225	COG0626	cystathionine gamma-synthase activity
BEST7613_4226	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7613_4227	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BEST7613_4228	COG2226	methyltransferase
BEST7613_4231	COG0768	penicillin binding
BEST7613_4232	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BEST7613_4233	COG0572	uridine kinase
BEST7613_4237	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BEST7613_4238	COG3906	Belongs to the UPF0473 family
BEST7613_4239	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BEST7613_4240	COG4472	Bacterial protein of unknown function (DUF965)
BEST7613_4241	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BEST7613_4242	COG0628	permease
BEST7613_4243	COG1126	abc transporter atp-binding protein
BEST7613_4244	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_4245	COG0765	amino acid transport
BEST7613_4246	COG0765	amino acid transport
BEST7613_4249	COG3881	PFAM PRC-barrel domain
BEST7613_4250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BEST7613_4251	COG0457	Tetratricopeptide repeat
BEST7613_4252	COG0482	sulfurtransferase activity
BEST7613_4253	COG1104	cysteine desulfurase activity
BEST7613_4254	COG1959	2 iron, 2 sulfur cluster binding
BEST7613_4255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BEST7613_4256	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BEST7613_4257	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BEST7613_4258	COG0124	histidyl-tRNA synthetase
BEST7613_4260	COG4991	sh3 domain protein
BEST7613_4260	COG3103	Sh3 type 3 domain protein
BEST7613_4260	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7613_4261	COG1490	D-aminoacyl-tRNA deacylase activity
BEST7613_4262	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BEST7613_4263	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BEST7613_4264	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BEST7613_4264	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BEST7613_4265	COG5416	Lipopolysaccharide assembly protein A domain
BEST7613_4266	COG0490	domain, Protein
BEST7613_4267	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7613_4267	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7613_4269	COG2244	polysaccharide biosynthetic process
BEST7613_4270	COG2323	membrane
BEST7613_4272	COG1862	Preprotein translocase
BEST7613_4273	COG0343	queuine tRNA-ribosyltransferase activity
BEST7613_4274	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BEST7613_4276	COG2255	four-way junction helicase activity
BEST7613_4277	COG0632	four-way junction helicase activity
BEST7613_4279	COG2814	Major facilitator Superfamily
BEST7613_4280	COG0673	inositol 2-dehydrogenase activity
BEST7613_4281	COG2112	serine threonine protein kinase
BEST7613_4285	COG1115	amino acid carrier protein
BEST7613_4286	COG0217	transcriptional regulatory protein
BEST7613_4288	COG1388	LysM domain
BEST7613_4289	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BEST7613_4290	COG0157	Belongs to the NadC ModD family
BEST7613_4291	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BEST7613_4292	COG1104	cysteine desulfurase activity
BEST7613_4293	COG1827	regulation of RNA biosynthetic process
BEST7613_4294	COG0077	Prephenate dehydratase
BEST7613_4295	COG4492	Belongs to the UPF0735 family
BEST7613_4296	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BEST7613_4297	COG3290	protein histidine kinase activity
BEST7613_4298	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BEST7613_4299	COG2868	ribosomal protein
BEST7613_4300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BEST7613_4301	COG1994	Peptidase M50
BEST7613_4302	COG0739	heme binding
BEST7613_4303	COG2894	cell division
BEST7613_4304	COG0850	regulation of cytokinetic process
BEST7613_4305	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BEST7613_4306	COG1792	Involved in formation and maintenance of cell shape
BEST7613_4307	COG1077	Cell shape determining protein MreB Mrl
BEST7613_4308	COG2003	Belongs to the UPF0758 family
BEST7613_4309	COG0424	maF-like protein
BEST7613_4311	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BEST7613_4312	COG0285	dihydrofolate synthase activity
BEST7613_4313	COG0525	valine-tRNA ligase activity
BEST7613_4315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7613_4316	COG1388	LysM domain
BEST7613_4317	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BEST7613_4318	COG0113	porphobilinogen synthase activity
BEST7613_4319	COG1587	Uroporphyrinogen-III synthase
BEST7613_4320	COG0181	hydroxymethylbilane synthase activity
BEST7613_4321	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BEST7613_4322	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BEST7613_4324	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BEST7613_4325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BEST7613_4326	COG1067	ATP-dependent peptidase activity
BEST7613_4326	COG0470	DNA polymerase III
BEST7613_4327	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BEST7613_4328	COG0544	peptidyl-prolyl cis-trans isomerase activity
BEST7613_4329	COG0457	Tetratricopeptide repeat
BEST7613_4329	COG1477	protein flavinylation
BEST7613_4330	COG0066	3-isopropylmalate dehydratase activity
BEST7613_4331	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BEST7613_4333	COG1136	(ABC) transporter
BEST7613_4333	COG0577	efflux transmembrane transporter activity
BEST7613_4334	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BEST7613_4335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BEST7613_4336	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7613_4340	COG0549	Belongs to the carbamate kinase family
BEST7613_4341	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7613_4344	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BEST7613_4349	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BEST7613_4352	COG0137	argininosuccinate synthase activity
BEST7613_4353	COG1064	alcohol dehydrogenase
BEST7613_4357	COG1842	Phage shock protein A
BEST7613_4360	COG0723	plastoquinol--plastocyanin reductase activity
BEST7613_4366	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BEST7613_4368	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BEST7613_4369	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BEST7613_4372	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7613_4374	COG0326	Molecular chaperone. Has ATPase activity
BEST7613_4380	COG0546	phosphoglycolate phosphatase activity
BEST7613_4381	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BEST7613_4387	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BEST7613_4388	COG0129	dihydroxy-acid dehydratase activity
BEST7613_4389	COG0322	excinuclease ABC activity
BEST7613_4391	COG4581	dead DEAH box helicase
BEST7613_4401	COG2153	protein acetylation
BEST7613_4410	COG2197	response regulator
BEST7613_4413	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BEST7613_4418	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BEST7613_4422	COG5001	Diguanylate cyclase
BEST7613_4422	COG4251	negative regulation of phosphorylation
BEST7613_4422	COG3706	GGDEF domain
BEST7613_4422	COG2203	Gaf domain
BEST7613_4423	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BEST7613_4427	COG3659	wide pore channel activity
BEST7613_4428	COG1473	amidohydrolase
BEST7613_4429	COG0170	dolichyl monophosphate biosynthetic process
BEST7613_4433	COG2994	toxin metabolic process
BEST7613_4437	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BEST7613_4438	COG4251	negative regulation of phosphorylation
BEST7613_4443	COG1598	PFAM Uncharacterised protein family UPF0150
BEST7613_4448	COG0825	malonyl-CoA metabolic process
BEST7613_4451	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BEST7613_4453	COG0148	phosphopyruvate hydratase activity
BEST7613_4454	COG0457	Tetratricopeptide repeat
BEST7613_4456	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BEST7613_4458	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BEST7613_4460	COG1543	Belongs to the glycosyl hydrolase 57 family
BEST7613_4462	COG3842	ATPase activity
BEST7613_4464	COG3300	MHYT domain
BEST7613_4464	COG5001	Diguanylate cyclase
BEST7613_4465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BEST7613_4469	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7613_4471	COG3706	GGDEF domain
BEST7613_4471	COG2203	Gaf domain
BEST7613_4471	COG4251	negative regulation of phosphorylation
BEST7613_4471	COG5001	Diguanylate cyclase
BEST7613_4472	COG3385	transposase activity
BEST7613_4473	COG2205	protein histidine kinase activity
BEST7613_4476	COG0363	glucosamine-6-phosphate deaminase activity
BEST7613_4479	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BEST7613_4487	COG3264	Mechanosensitive ion channel
BEST7613_4487	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BEST7613_4488	COG2052	Domain of unknown function (DUF370)
BEST7613_4493	COG0739	heme binding
BEST7613_4494	COG1691	(AIR) carboxylase
BEST7613_4497	COG2319	Wd-40 repeat
BEST7613_4498	COG0463	Glycosyl transferase, family 2
BEST7613_4499	COG0316	Belongs to the HesB IscA family
BEST7613_4500	COG1191	sigma factor activity
BEST7613_4503	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BEST7613_4504	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BEST7613_4505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BEST7613_4506	COG0579	oxidoreductase
BEST7613_4507	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BEST7613_4509	COG0505	Belongs to the CarA family
BEST7613_4510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BEST7613_4512	COG0070	glutamate synthase
BEST7613_4512	COG0067	glutamate synthase
BEST7613_4512	COG0069	glutamate synthase activity
BEST7613_4513	COG0435	Glutathione S-transferase
BEST7613_4516	COG1049	propionate catabolic process, 2-methylcitrate cycle
BEST7613_4520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BEST7613_4522	COG1166	arginine decarboxylase activity
BEST7613_4527	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BEST7613_4528	COG0339	signal peptide processing
BEST7613_4535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7613_4538	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BEST7613_4539	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BEST7613_4541	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BEST7613_4542	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BEST7613_4543	COG0731	radical SAM domain protein
BEST7613_4544	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BEST7613_4545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BEST7613_4548	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BEST7613_4551	COG2165	general secretion pathway protein
BEST7613_4552	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BEST7613_4553	COG4208	sulfate ABC transporter
BEST7613_4554	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BEST7613_4555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BEST7613_4556	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BEST7613_4559	COG0483	inositol monophosphate 1-phosphatase activity
BEST7613_4560	COG0745	RESPONSE REGULATOR receiver
BEST7613_4566	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BEST7613_4567	COG1834	amidinotransferase
BEST7613_4569	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BEST7613_4571	COG2193	ferroxidase activity
BEST7613_4573	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BEST7613_4574	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BEST7613_4575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7613_4576	COG0308	aminopeptidase N
BEST7613_4580	COG1070	Carbohydrate kinase
BEST7613_4581	COG2166	iron-sulfur cluster assembly
BEST7613_4582	COG0167	dihydroorotate dehydrogenase activity
BEST7613_4583	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BEST7613_4584	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_4585	COG0839	Belongs to the complex I subunit 6 family
BEST7613_4586	COG0713	ATP synthesis coupled electron transport
BEST7613_4587	COG0525	valine-tRNA ligase activity
BEST7613_4591	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BEST7613_4592	COG1994	Peptidase M50
BEST7613_4592	COG0517	IMP dehydrogenase activity
BEST7613_4595	COG0237	dephospho-CoA kinase activity
BEST7613_4597	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BEST7613_4598	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BEST7613_4599	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BEST7613_4600	COG0544	peptidyl-prolyl cis-trans isomerase activity
BEST7613_4601	COG0740	serine-type endopeptidase activity
BEST7613_4602	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BEST7613_4603	COG0569	domain protein
BEST7613_4604	COG0004	ammonium transporteR
BEST7613_4605	COG0004	ammonium transporteR
BEST7613_4606	COG0134	indole-3-glycerol-phosphate synthase activity
BEST7613_4608	COG1218	3'(2'),5'-bisphosphate nucleotidase
BEST7613_4609	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BEST7613_4610	COG0484	heat shock protein binding
BEST7613_4612	COG1162	GTPase activity
BEST7613_4614	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BEST7613_4615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BEST7613_4616	COG2119	membrane
BEST7613_4618	COG1192	Involved in chromosome partitioning
BEST7613_4620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BEST7613_4622	COG0629	single-stranded DNA binding
BEST7613_4623	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BEST7613_4624	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BEST7613_4625	COG0569	domain protein
BEST7613_4627	COG0017	Asparaginyl-tRNA synthetase
BEST7613_4631	COG2314	TM2 domain
BEST7613_4632	COG1136	(ABC) transporter
BEST7613_4634	COG0133	tryptophan synthase activity
BEST7613_4635	COG0740	serine-type endopeptidase activity
BEST7613_4637	COG0463	Glycosyl transferase, family 2
BEST7613_4638	COG0018	arginyl-trna synthetase
BEST7613_4639	COG1160	GTP binding
BEST7613_4640	COG0019	diaminopimelate decarboxylase activity
BEST7613_4641	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BEST7613_4642	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BEST7613_4643	COG0598	Magnesium transport protein CorA
BEST7613_4644	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7613_4647	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BEST7613_4650	COG0741	lytic transglycosylase activity
BEST7613_4651	COG2205	protein histidine kinase activity
BEST7613_4654	COG0395	ABC-type sugar transport system, permease component
BEST7613_4655	COG1175	transmembrane transport
BEST7613_4656	COG1653	transport
BEST7613_4657	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BEST7613_4658	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BEST7613_4659	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BEST7613_4660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BEST7613_4661	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BEST7613_4662	COG0724	RNA recognition motif
BEST7613_4664	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7613_4666	COG1116	anion transmembrane transporter activity
BEST7613_4667	COG1116	anion transmembrane transporter activity
BEST7613_4667	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7613_4668	COG3659	wide pore channel activity
BEST7613_4669	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7613_4670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7613_4671	COG0583	DNA-binding transcription factor activity
BEST7613_4672	COG0857	belongs to the CobB CobQ family
BEST7613_4678	COG1597	lipid kinase activity
BEST7613_4678	COG1803	Methylglyoxal synthase
BEST7613_4679	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BEST7613_4680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7613_4681	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7613_4683	COG0784	Response regulator, receiver
BEST7613_4686	COG0840	transmembrane signaling receptor activity
BEST7613_4686	COG2203	Gaf domain
BEST7613_4687	COG0840	transmembrane signaling receptor activity
BEST7613_4691	COG0438	transferase activity, transferring glycosyl groups
BEST7613_4696	COG0725	ABC transporter, periplasmic molybdate-binding protein
BEST7613_4697	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BEST7613_4699	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BEST7613_4699	COG1013	pyruvate-flavodoxin oxidoreductase activity
BEST7613_4699	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BEST7613_4699	COG0674	pyruvate-flavodoxin oxidoreductase activity
BEST7613_4703	COG0205	6-phosphofructokinase activity
BEST7613_4704	COG0668	transmembrane transport
BEST7613_4705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7613_4706	COG2886	Uncharacterised protein family (UPF0175)
BEST7613_4709	COG0343	queuine tRNA-ribosyltransferase activity
BEST7613_4711	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BEST7613_4715	COG0392	lysyltransferase activity
BEST7613_4716	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BEST7613_4717	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7613_4718	COG0251	oxidation-reduction process
BEST7613_4723	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7613_4723	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7613_4725	COG0598	Magnesium transport protein CorA
BEST7613_4726	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7613_4736	COG0789	Transcriptional regulator
BEST7613_4741	COG0401	homolog of Blt101
BEST7613_4743	COG4991	sh3 domain protein
BEST7613_4743	COG0515	serine threonine protein kinase
BEST7613_4743	COG3064	Membrane
BEST7613_4745	COG1716	ATPase activity
BEST7613_4745	COG0842	Transport permease protein
BEST7613_4745	COG1131	(ABC) transporter
BEST7613_4746	COG5001	Diguanylate cyclase
BEST7613_4746	COG2203	Gaf domain
BEST7613_4746	COG3706	GGDEF domain
BEST7613_4746	COG4251	negative regulation of phosphorylation
BEST7613_4749	COG2197	response regulator
BEST7613_4750	COG2072	flavoprotein involved in K transport
BEST7613_4755	COG2144	transferase activity, transferring acyl groups
BEST7613_4759	COG0745	RESPONSE REGULATOR receiver
BEST7613_4760	COG5002	protein histidine kinase activity
BEST7613_4761	COG2217	Heavy metal translocating P-type atpase
BEST7613_4762	COG0640	Transcriptional regulator
BEST7613_4763	COG1742	UPF0060 membrane protein
BEST7613_4764	COG2217	Heavy metal translocating P-type atpase
BEST7613_4766	COG2814	Major facilitator Superfamily
BEST7613_4771	COG5002	protein histidine kinase activity
BEST7613_4772	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BEST7613_4775	COG1051	belongs to the nudix hydrolase family
BEST7613_4775	COG1056	cytidyltransferase-related domain
BEST7613_4778	COG0024	Methionine aminopeptidase
BEST7613_4786	COG4221	oxidoreductase activity
BEST7613_4787	COG2267	carboxylic ester hydrolase activity
BEST7613_4788	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BEST7613_4788	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BEST7613_4789	COG2197	response regulator
BEST7613_4790	COG4585	Histidine kinase
BEST7613_4795	COG1032	radical SAM domain protein
BEST7613_4798	COG0454	-acetyltransferase
BEST7613_4799	COG0737	Belongs to the 5'-nucleotidase family
BEST7613_4800	COG0398	Pfam SNARE associated Golgi protein
BEST7613_4803	COG3706	GGDEF domain
BEST7613_4803	COG0745	RESPONSE REGULATOR receiver
BEST7613_4804	COG0574	Belongs to the PEP-utilizing enzyme family
BEST7613_4804	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BEST7613_4807	COG1716	ATPase activity
BEST7613_4808	COG0850	regulation of cytokinetic process
BEST7613_4809	COG2894	cell division
BEST7613_4810	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BEST7613_4813	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BEST7613_4817	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BEST7613_4821	COG0745	RESPONSE REGULATOR receiver
BEST7613_4825	COG1192	Involved in chromosome partitioning
BEST7613_4826	COG0784	Response regulator, receiver
BEST7613_4826	COG2205	protein histidine kinase activity
BEST7613_4827	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BEST7613_4831	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BEST7613_4833	COG1473	amidohydrolase
BEST7613_4836	COG1192	Involved in chromosome partitioning
BEST7613_4838	COG2304	oxidoreductase activity
BEST7613_4839	COG1480	7TM receptor with intracellular HD hydrolase
BEST7613_4840	COG0800	Aldolase
BEST7613_4841	COG0004	ammonium transporteR
BEST7613_4843	COG0463	Glycosyl transferase, family 2
BEST7613_4843	COG0457	Tetratricopeptide repeat
BEST7613_4846	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BEST7613_4849	COG3118	belongs to the thioredoxin family
BEST7613_4850	COG2081	HI0933 family
BEST7613_4851	COG0469	pyruvate kinase activity
BEST7613_4855	COG1492	cobalamin metabolic process
BEST7613_4856	COG0668	transmembrane transport
BEST7613_4860	COG1132	(ABC) transporter
BEST7613_4861	COG0837	glucose binding
BEST7613_4862	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7613_4865	COG0628	permease
BEST7613_4866	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BEST7613_4867	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BEST7613_4868	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BEST7613_4873	COG0047	phosphoribosylformylglycinamidine synthase activity
BEST7613_4874	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BEST7613_4876	COG0456	acetyltransferase
BEST7613_4878	COG2205	protein histidine kinase activity
BEST7613_4879	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7613_4882	COG1840	ABC-type Fe3 transport system, periplasmic component
BEST7613_4883	COG0811	peptide transport
BEST7613_4884	COG0848	biopolymer transport protein
BEST7613_4885	COG0848	biopolymer transport protein
BEST7613_4888	COG3264	Mechanosensitive ion channel
BEST7613_4888	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BEST7613_4889	COG0586	Pfam SNARE associated Golgi protein
BEST7613_4890	COG0436	Aminotransferase
BEST7613_4893	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_4895	COG0515	serine threonine protein kinase
BEST7613_4898	COG0745	RESPONSE REGULATOR receiver
BEST7613_4899	COG4251	negative regulation of phosphorylation
BEST7613_4900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BEST7613_4902	COG0131	Imidazoleglycerol-phosphate dehydratase
BEST7613_4903	COG1131	(ABC) transporter
BEST7613_4905	COG0659	secondary active sulfate transmembrane transporter activity
BEST7613_4907	COG0484	heat shock protein binding
BEST7613_4908	COG1216	Glycosyl transferase, family 2
BEST7613_4909	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_4910	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BEST7613_4911	COG2226	methyltransferase
BEST7613_4913	COG0443	Heat shock 70 kDa protein
BEST7613_4914	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BEST7613_4915	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BEST7613_4916	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BEST7613_4917	COG0513	Belongs to the DEAD box helicase family
BEST7613_4918	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7613_4919	COG0745	RESPONSE REGULATOR receiver
BEST7613_4920	COG0328	RNA-DNA hybrid ribonuclease activity
BEST7613_4923	COG0720	synthase
BEST7613_4924	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BEST7613_4927	COG0003	Pfam Anion-transporting ATPase
BEST7613_4928	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7613_4929	COG0719	Fe-S assembly protein
BEST7613_4930	COG0396	ATPase activity
BEST7613_4931	COG0719	Fe-S assembly protein
BEST7613_4934	COG0357	Ribosomal RNA small subunit methyltransferase G
BEST7613_4936	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BEST7613_4937	COG3706	GGDEF domain
BEST7613_4937	COG4251	negative regulation of phosphorylation
BEST7613_4937	COG2203	Gaf domain
BEST7613_4937	COG5001	Diguanylate cyclase
BEST7613_4938	COG1959	2 iron, 2 sulfur cluster binding
BEST7613_4940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BEST7613_4943	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7613_4946	COG4251	negative regulation of phosphorylation
BEST7613_4946	COG2203	Gaf domain
BEST7613_4946	COG3706	GGDEF domain
BEST7613_4946	COG5001	Diguanylate cyclase
BEST7613_4949	COG0154	amidase activity
BEST7613_4950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BEST7613_4951	COG2226	methyltransferase
BEST7613_4952	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BEST7613_4953	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BEST7613_4956	COG0714	Associated with various cellular activities
BEST7613_4957	COG0305	Participates in initiation and elongation during chromosome replication
BEST7613_4957	COG1372	Participates in initiation and elongation during chromosome replication
BEST7613_4960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BEST7613_4961	COG0659	secondary active sulfate transmembrane transporter activity
BEST7613_4962	COG4251	negative regulation of phosphorylation
BEST7613_4962	COG3706	GGDEF domain
BEST7613_4962	COG5001	Diguanylate cyclase
BEST7613_4962	COG2203	Gaf domain
BEST7613_4963	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BEST7613_4964	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BEST7613_4965	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BEST7613_4967	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BEST7613_4969	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7613_4972	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BEST7613_4975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BEST7613_4977	COG2124	cytochrome p450
BEST7613_4987	COG0023	Translation Initiation Factor
BEST7613_4988	COG3063	Type IV pilus biogenesis stability protein PilW
BEST7613_4989	COG2251	uridine kinase activity
BEST7613_4990	COG0613	PHP domain protein
BEST7613_4991	COG0426	domain, Protein
BEST7613_4991	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7613_4992	COG4243	Vitamin k epoxide reductase
BEST7613_4994	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
BEST7613_4995	COG0024	Methionine aminopeptidase
BEST7613_4996	COG3263	regulation of cellular component size
BEST7613_5000	COG0193	aminoacyl-tRNA hydrolase activity
BEST7613_5003	COG0039	L-malate dehydrogenase activity
BEST7613_5004	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BEST7613_5005	COG0494	nUDIX hydrolase
BEST7613_5007	COG0024	Methionine aminopeptidase
BEST7613_5009	COG0156	8-amino-7-oxononanoate synthase activity
BEST7613_5017	COG1032	radical SAM domain protein
BEST7613_5018	COG0606	chelatase, subunit chli
BEST7613_5020	COG0314	molybdopterin synthase activity
BEST7613_5022	COG0746	molybdenum cofactor guanylyltransferase activity
BEST7613_5022	COG0315	cyclic pyranopterin monophosphate synthase activity
BEST7613_5023	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BEST7613_5024	COG0303	'Molybdopterin
BEST7613_5025	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BEST7613_5028	COG0534	Mate efflux family protein
BEST7613_5029	COG1309	transcriptional regulator
BEST7613_5032	COG0646	methionine synthase
BEST7613_5032	COG1410	methionine synthase
BEST7613_5038	COG1410	methionine synthase
BEST7613_5038	COG0646	methionine synthase
BEST7613_5041	COG2202	Pas domain
BEST7613_5041	COG2205	protein histidine kinase activity
BEST7613_5046	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BEST7613_5047	COG0824	Thioesterase
BEST7613_5052	COG4178	(ABC) transporter
BEST7613_5055	COG0762	integral membrane protein
BEST7613_5056	COG2048	Heterodisulfide reductase, subunit B
BEST7613_5057	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7613_5058	COG0121	glutamine amidotransferase
BEST7613_5063	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BEST7613_5065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7613_5066	COG2247	cell wall binding repeat
BEST7613_5066	COG2385	sporulation resulting in formation of a cellular spore
BEST7613_5068	COG0792	nuclease activity
BEST7613_5069	COG1546	Belongs to the CinA family
BEST7613_5069	COG1058	Belongs to the CinA family
BEST7613_5070	COG0302	gtp cyclohydrolase
BEST7613_5071	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BEST7613_5073	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BEST7613_5075	COG1598	PFAM Uncharacterised protein family UPF0150
BEST7613_5079	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BEST7613_5081	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BEST7613_5083	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BEST7613_5084	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BEST7613_5087	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BEST7613_5088	COG0438	transferase activity, transferring glycosyl groups
BEST7613_5094	COG0310	cobalt ion transport
BEST7613_5096	COG1122	ATPase activity
BEST7613_5098	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BEST7613_5101	COG0589	response to stress
BEST7613_5101	COG0475	glutathione-regulated potassium exporter activity
BEST7613_5103	COG0406	alpha-ribazole phosphatase activity
BEST7613_5104	COG0745	RESPONSE REGULATOR receiver
BEST7613_5106	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BEST7613_5108	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7613_5109	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7613_5113	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BEST7613_5114	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BEST7613_5117	COG2211	Major facilitator Superfamily
BEST7613_5120	COG5002	protein histidine kinase activity
BEST7613_5121	COG0668	transmembrane transport
BEST7613_5122	COG0752	glycyl-tRNA synthetase alpha subunit
BEST7613_5125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BEST7613_5127	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BEST7613_5129	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7613_5129	COG2022	thiamine diphosphate biosynthetic process
BEST7613_5130	COG2255	four-way junction helicase activity
BEST7613_5132	COG2119	membrane
BEST7613_5133	COG0653	protein targeting
BEST7613_5136	COG1842	Phage shock protein A
BEST7613_5137	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BEST7613_5144	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BEST7613_5145	COG0473	3-isopropylmalate dehydrogenase activity
BEST7613_5146	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7613_5147	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BEST7613_5148	COG0440	acetolactate synthase activity
BEST7613_5149	COG0028	Belongs to the TPP enzyme family
BEST7613_5151	COG0454	-acetyltransferase
BEST7613_5152	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BEST7613_5153	COG0622	Phosphoesterase
BEST7613_5154	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BEST7613_5155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BEST7613_5156	COG5401	PFAM Sporulation and spore germination
BEST7613_5157	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BEST7613_5158	COG1846	Transcriptional regulator
BEST7613_5159	COG2197	response regulator
BEST7613_5160	COG0824	Thioesterase
BEST7613_5161	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BEST7613_5162	COG1053	succinate dehydrogenase
BEST7613_5163	COG2009	succinate dehydrogenase
BEST7613_5164	COG1719	4-vinyl reductase, 4VR
BEST7613_5165	COG0527	aspartate kinase activity
BEST7613_5166	COG0322	excinuclease ABC activity
BEST7613_5167	COG3118	belongs to the thioredoxin family
BEST7613_5168	COG3534	alpha-L-arabinofuranosidase
BEST7613_5169	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BEST7613_5170	COG2086	electron transfer activity
BEST7613_5171	COG1024	Enoyl-CoA hydratase
BEST7613_5172	COG1309	transcriptional regulator
BEST7613_5173	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_5174	COG3766	membrane
BEST7613_5175	COG1193	negative regulation of DNA recombination
BEST7613_5176	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BEST7613_5176	COG1796	DNA polymerase
BEST7613_5177	COG1286	toxin biosynthetic process
BEST7613_5178	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BEST7613_5179	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BEST7613_5180	COG0072	phenylalanine-tRNA ligase activity
BEST7613_5180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7613_5181	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BEST7613_5182	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7613_5184	COG3835	regulator
BEST7613_5185	COG0277	FAD linked oxidase domain protein
BEST7613_5186	COG0247	lactate metabolic process
BEST7613_5187	COG0346	lactoylglutathione lyase activity
BEST7613_5189	COG1966	Carbon starvation protein
BEST7613_5190	COG3534	alpha-L-arabinofuranosidase
BEST7613_5191	COG0395	ABC-type sugar transport system, permease component
BEST7613_5192	COG1175	transmembrane transport
BEST7613_5193	COG1653	transport
BEST7613_5194	COG0371	Dehydrogenase
BEST7613_5195	COG0647	UMP catabolic process
BEST7613_5196	COG0235	Class ii aldolase
BEST7613_5197	COG1069	ribulokinase activity
BEST7613_5198	COG2160	L-arabinose isomerase activity
BEST7613_5199	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7613_5200	COG1363	Peptidase, m42
BEST7613_5202	COG3326	Membrane
BEST7613_5203	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BEST7613_5204	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BEST7613_5205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BEST7613_5207	COG1346	cytolysis
BEST7613_5208	COG1380	Effector of murein hydrolase LrgA
BEST7613_5209	COG3279	Response regulator of the LytR AlgR family
BEST7613_5210	COG3275	phosphorelay sensor kinase activity
BEST7613_5212	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BEST7613_5214	COG0398	Pfam SNARE associated Golgi protein
BEST7613_5215	COG1484	DNA-dependent DNA replication
BEST7613_5216	COG3611	Membrane attachment protein
BEST7613_5217	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BEST7613_5218	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BEST7613_5219	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7613_5220	COG1733	regulation of RNA biosynthetic process
BEST7613_5221	COG2814	Major facilitator Superfamily
BEST7613_5222	COG0656	L-ascorbic acid biosynthetic process
BEST7613_5223	COG0237	dephospho-CoA kinase activity
BEST7613_5224	COG1971	Probably functions as a manganese efflux pump
BEST7613_5225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BEST7613_5226	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7613_5226	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BEST7613_5227	COG5002	protein histidine kinase activity
BEST7613_5228	COG0745	RESPONSE REGULATOR receiver
BEST7613_5229	COG0039	L-malate dehydrogenase activity
BEST7613_5230	COG0538	isocitrate dehydrogenase activity
BEST7613_5231	COG0372	Belongs to the citrate synthase family
BEST7613_5232	COG2707	UPF0756 membrane protein
BEST7613_5233	COG0628	permease
BEST7613_5234	COG3030	protein affecting phage T7 exclusion by the F plasmid
BEST7613_5235	COG0469	pyruvate kinase activity
BEST7613_5236	COG0205	6-phosphofructokinase activity
BEST7613_5237	COG0825	malonyl-CoA metabolic process
BEST7613_5238	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BEST7613_5239	COG0281	malic enzyme
BEST7613_5240	COG0587	DNA-directed DNA polymerase activity
BEST7613_5244	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BEST7613_5246	COG4109	DRTGG domain
BEST7613_5247	COG0730	response to heat
BEST7613_5248	COG1473	amidohydrolase
BEST7613_5249	COG0196	riboflavin kinase activity
BEST7613_5250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7613_5251	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BEST7613_5252	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7613_5253	COG1126	abc transporter atp-binding protein
BEST7613_5254	COG0765	amino acid transport
BEST7613_5255	COG0765	amino acid transport
BEST7613_5256	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_5257	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_5258	COG0454	-acetyltransferase
BEST7613_5259	COG0583	DNA-binding transcription factor activity
BEST7613_5260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BEST7613_5261	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_5263	COG0165	Argininosuccinate lyase
BEST7613_5264	COG0137	argininosuccinate synthase activity
BEST7613_5265	COG0137	argininosuccinate synthase activity
BEST7613_5266	COG0521	Mo-molybdopterin cofactor biosynthetic process
BEST7613_5267	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BEST7613_5268	COG0827	DNA restriction-modification system
BEST7613_5269	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BEST7613_5270	COG3874	Sporulation protein YtfJ
BEST7613_5272	COG1714	RDD family
BEST7613_5273	COG0616	signal peptide processing
BEST7613_5274	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7613_5275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BEST7613_5276	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BEST7613_5278	COG0301	tRNA thio-modification
BEST7613_5279	COG1104	cysteine desulfurase activity
BEST7613_5280	COG1114	Component of the transport system for branched-chain amino acids
BEST7613_5281	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BEST7613_5282	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BEST7613_5283	COG1309	transcriptional regulator
BEST7613_5284	COG1956	GAF domain-containing protein
BEST7613_5285	COG2199	diguanylate cyclase activity
BEST7613_5285	COG2203	Gaf domain
BEST7613_5286	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BEST7613_5288	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7613_5289	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BEST7613_5290	COG0454	-acetyltransferase
BEST7613_5291	COG0517	IMP dehydrogenase activity
BEST7613_5292	COG0123	including yeast histone deacetylase and acetoin utilization protein
BEST7613_5293	COG1360	Flagellar Motor Protein
BEST7613_5294	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BEST7613_5295	COG1609	Transcriptional regulator
BEST7613_5296	COG1605	Chorismate mutase
BEST7613_5296	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BEST7613_5297	COG3118	belongs to the thioredoxin family
BEST7613_5298	COG4980	gas vesicle protein
BEST7613_5299	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BEST7613_5300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BEST7613_5301	COG1674	ftsk spoiiie
BEST7613_5302	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7613_5303	COG4848	Belongs to the UPF0354 family
BEST7613_5304	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_5306	COG1363	Peptidase, m42
BEST7613_5307	COG5584	Small secreted protein
BEST7613_5308	COG0281	malic enzyme
BEST7613_5309	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_5310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BEST7613_5312	COG0510	thiamine kinase activity
BEST7613_5313	COG1523	belongs to the glycosyl hydrolase 13 family
BEST7613_5314	COG1597	lipid kinase activity
BEST7613_5316	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BEST7613_5317	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BEST7613_5318	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7613_5319	COG2252	PERMEase
BEST7613_5320	COG4473	ABC transporter
BEST7613_5321	COG1131	(ABC) transporter
BEST7613_5323	COG1349	DNA-binding transcription factor activity
BEST7613_5324	COG1187	pseudouridine synthase activity
BEST7613_5325	COG2244	polysaccharide biosynthetic process
BEST7613_5326	COG2081	HI0933 family
BEST7613_5327	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BEST7613_5329	COG5578	integral membrane protein
BEST7613_5330	COG0673	inositol 2-dehydrogenase activity
BEST7613_5331	COG1653	transport
BEST7613_5332	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BEST7613_5333	COG4209	transmembrane transport
BEST7613_5334	COG2207	Transcriptional regulator
BEST7613_5335	COG1653	transport
BEST7613_5336	COG0395	ABC-type sugar transport system, permease component
BEST7613_5337	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7613_5338	COG2124	cytochrome p450
BEST7613_5339	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BEST7613_5340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BEST7613_5341	COG0156	8-amino-7-oxononanoate synthase activity
BEST7613_5342	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BEST7613_5343	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BEST7613_5344	COG1073	alpha beta
BEST7613_5349	COG1486	melibiose metabolic process
BEST7613_5350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BEST7613_5351	COG0495	leucyl-tRNA aminoacylation
BEST7613_5353	COG2202	Pas domain
BEST7613_5353	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_5354	COG2814	Major facilitator Superfamily
BEST7613_5355	COG2433	Pfam Transposase IS66
BEST7613_5356	COG0577	efflux transmembrane transporter activity
BEST7613_5357	COG1136	(ABC) transporter
BEST7613_5358	COG2205	protein histidine kinase activity
BEST7613_5359	COG0745	RESPONSE REGULATOR receiver
BEST7613_5360	COG0577	efflux transmembrane transporter activity
BEST7613_5361	COG1136	(ABC) transporter
BEST7613_5364	COG1131	(ABC) transporter
BEST7613_5365	COG1725	Transcriptional regulator
BEST7613_5367	COG1242	4 iron, 4 sulfur cluster binding
BEST7613_5368	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BEST7613_5371	COG0653	protein targeting
BEST7613_5374	COG1842	Phage shock protein A
BEST7613_5375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BEST7613_5377	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BEST7613_5380	COG0581	inorganic phosphate transmembrane transporter activity
BEST7613_5381	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7613_5382	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BEST7613_5384	COG4232	protein-disulfide reductase activity
BEST7613_5387	COG0475	glutathione-regulated potassium exporter activity
BEST7613_5391	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BEST7613_5393	COG2091	lysine biosynthetic process via aminoadipic acid
BEST7613_5394	COG0460	homoserine dehydrogenase
BEST7613_5397	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_5400	COG0728	peptidoglycan biosynthetic process
BEST7613_5402	COG5002	protein histidine kinase activity
BEST7613_5403	COG0525	valine-tRNA ligase activity
BEST7613_5404	COG2890	protein-(glutamine-N5) methyltransferase activity
BEST7613_5405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7613_5410	COG0556	nucleotide-excision repair
BEST7613_5411	COG0784	Response regulator, receiver
BEST7613_5412	COG4251	negative regulation of phosphorylation
BEST7613_5413	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BEST7613_5415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BEST7613_5418	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BEST7613_5419	COG0590	tRNA wobble adenosine to inosine editing
BEST7613_5420	COG3224	Antibiotic biosynthesis monooxygenase
BEST7613_5421	COG0439	Biotin carboxylase
BEST7613_5422	COG0489	protein tyrosine kinase activity
BEST7613_5423	COG0612	Peptidase, M16
BEST7613_5424	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7613_5424	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BEST7613_5426	COG0116	Belongs to the methyltransferase superfamily
BEST7613_5427	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BEST7613_5428	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BEST7613_5429	COG0443	Heat shock 70 kDa protein
BEST7613_5430	COG0628	permease
BEST7613_5436	COG0628	permease
BEST7613_5438	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_5439	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BEST7613_5441	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BEST7613_5442	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BEST7613_5444	COG0440	acetolactate synthase activity
BEST7613_5446	COG0625	glutathione transferase activity
BEST7613_5450	COG0788	formyltetrahydrofolate deformylase activity
BEST7613_5453	COG1234	tRNA 3'-trailer cleavage
BEST7613_5456	COG0596	Alpha beta hydrolase
BEST7613_5457	COG2062	phosphohistidine phosphatase, SixA
BEST7613_5458	COG0372	Belongs to the citrate synthase family
BEST7613_5459	COG0436	Aminotransferase
BEST7613_5466	COG0277	FAD linked oxidase domain protein
BEST7613_5471	COG0511	ligase activity, forming carbon-carbon bonds
BEST7613_5472	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BEST7613_5473	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BEST7613_5474	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7613_5475	COG0824	Thioesterase
BEST7613_5476	COG4399	Belongs to the UPF0754 family
BEST7613_5481	COG1131	(ABC) transporter
BEST7613_5482	COG0459	protein refolding
BEST7613_5483	COG3751	2OG-Fe(II) oxygenase superfamily
BEST7613_5484	COG3118	belongs to the thioredoxin family
BEST7613_5485	COG0586	Pfam SNARE associated Golgi protein
BEST7613_5487	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BEST7613_5490	COG2084	Dehydrogenase
BEST7613_5491	COG0805	protein transport
BEST7613_5492	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BEST7613_5493	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BEST7613_5496	COG3794	PFAM blue (type 1) copper domain protein
BEST7613_5500	COG0445	tRNA wobble uridine modification
BEST7613_5501	COG5002	protein histidine kinase activity
BEST7613_5502	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BEST7613_5505	COG0751	glycine-tRNA ligase activity
BEST7613_5507	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BEST7613_5508	COG5322	oxidoreductase activity
BEST7613_5512	COG1968	undecaprenyl-diphosphatase activity
BEST7613_5514	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BEST7613_5514	COG0519	Catalyzes the synthesis of GMP from XMP
BEST7613_5516	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BEST7613_5517	COG0616	signal peptide processing
BEST7613_5518	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BEST7613_5519	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BEST7613_5520	COG0436	Aminotransferase
BEST7613_5524	COG0114	fumarate hydratase activity
BEST7613_5525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BEST7613_5527	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BEST7613_5528	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BEST7613_5530	COG1285	pathogenesis
BEST7613_5533	COG4451	ribulose bisphosphate carboxylase, small
BEST7613_5535	COG1850	ribulose-bisphosphate carboxylase activity
BEST7613_5536	COG0793	Belongs to the peptidase S41A family
BEST7613_5541	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BEST7613_5542	COG0191	fructose-bisphosphate aldolase activity
BEST7613_5543	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BEST7613_5544	COG0542	response to heat
BEST7613_5553	COG0124	histidyl-tRNA synthetase
BEST7613_5554	COG0601	transmembrane transport
BEST7613_5558	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BEST7613_5559	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BEST7613_5562	COG3385	transposase activity
BEST7613_5564	COG3385	transposase activity
BEST7613_5569	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BEST7613_5574	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BEST7613_5575	COG0571	ribonuclease III activity
BEST7613_5579	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7613_5580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BEST7613_5583	COG0628	permease
BEST7613_5584	COG0149	triose-phosphate isomerase activity
BEST7613_5586	COG2205	protein histidine kinase activity
BEST7613_5587	COG1231	oxidoreductase activity
BEST7613_5589	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BEST7613_5591	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BEST7613_5592	COG0450	alkyl hydroperoxide reductase
BEST7613_5594	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BEST7613_5597	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BEST7613_5599	COG1131	(ABC) transporter
BEST7613_5606	COG2003	Belongs to the UPF0758 family
BEST7613_5607	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BEST7613_5608	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BEST7613_5609	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BEST7613_5610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7613_5611	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BEST7613_5612	COG0477	Major facilitator Superfamily
BEST7613_5613	COG3659	wide pore channel activity
BEST7613_5615	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BEST7613_5618	COG1376	ErfK ybiS ycfS ynhG family protein
BEST7613_5619	COG1040	competence protein
BEST7613_5620	COG1104	cysteine desulfurase activity
BEST7613_5624	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BEST7613_5625	COG0438	transferase activity, transferring glycosyl groups
BEST7613_5626	COG0742	ribosomal rna small subunit methyltransferase
BEST7613_5627	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_5628	COG0346	lactoylglutathione lyase activity
BEST7613_5630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BEST7613_5636	COG2308	Evidence 4 Homologs of previously reported genes of
BEST7613_5637	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BEST7613_5638	COG5002	protein histidine kinase activity
BEST7613_5639	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_5645	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BEST7613_5646	COG1187	pseudouridine synthase activity
BEST7613_5648	COG5001	Diguanylate cyclase
BEST7613_5649	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7613_5650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BEST7613_5651	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BEST7613_5654	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BEST7613_5657	COG1381	Involved in DNA repair and RecF pathway recombination
BEST7613_5660	COG3385	transposase activity
BEST7613_5663	COG2319	Wd-40 repeat
BEST7613_5664	COG1587	Uroporphyrinogen-III synthase
BEST7613_5667	COG0484	heat shock protein binding
BEST7613_5668	COG0443	Heat shock 70 kDa protein
BEST7613_5669	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BEST7613_5673	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BEST7613_5676	COG1937	Protein conserved in bacteria
BEST7613_5678	COG0516	GMP reductase activity
BEST7613_5678	COG0517	IMP dehydrogenase activity
BEST7613_5688	COG0237	dephospho-CoA kinase activity
BEST7613_5688	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7613_5693	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_5695	COG2197	response regulator
BEST7613_5700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7613_5701	COG1178	ABC-type Fe3 transport system permease component
BEST7613_5708	COG0643	Histidine kinase
BEST7613_5708	COG2198	Histidine kinase
BEST7613_5709	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BEST7613_5710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BEST7613_5713	COG0297	glycogen (starch) synthase activity
BEST7613_5715	COG0321	lipoyl(octanoyl) transferase activity
BEST7613_5716	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BEST7613_5717	COG0739	heme binding
BEST7613_5718	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BEST7613_5719	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BEST7613_5720	COG0217	transcriptional regulatory protein
BEST7613_5722	COG2217	Heavy metal translocating P-type atpase
BEST7613_5724	COG0508	dehydrogenase complex catalyzes the overall conversion of
BEST7613_5727	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BEST7613_5729	COG0463	Glycosyl transferase, family 2
BEST7613_5731	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
BEST7613_5735	COG0501	Belongs to the peptidase M48B family
BEST7613_5737	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BEST7613_5742	COG0105	UTP biosynthetic process
BEST7613_5746	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BEST7613_5752	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BEST7613_5754	COG2165	general secretion pathway protein
BEST7613_5760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BEST7613_5761	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BEST7613_5763	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
BEST7613_5768	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BEST7613_5769	COG0006	proline dipeptidase activity
BEST7613_5770	COG0740	serine-type endopeptidase activity
BEST7613_5771	COG0740	serine-type endopeptidase activity
BEST7613_5773	COG1459	type II secretion system
BEST7613_5778	COG0542	response to heat
BEST7613_5780	COG1598	PFAM Uncharacterised protein family UPF0150
BEST7613_5781	COG0528	UMP kinase activity
BEST7613_5782	COG0233	cytoplasmic translational termination
BEST7613_5787	COG2815	serine threonine protein kinase
BEST7613_5787	COG0515	serine threonine protein kinase
BEST7613_5796	COG2319	Wd-40 repeat
BEST7613_5796	COG1672	PFAM Archaeal ATPase
BEST7613_5799	COG2226	methyltransferase
BEST7613_5800	COG0418	dihydroorotase activity
BEST7613_5803	COG0697	spore germination
BEST7613_5804	COG0135	phosphoribosylanthranilate isomerase activity
BEST7613_5808	COG0347	Belongs to the P(II) protein family
BEST7613_5809	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BEST7613_5811	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BEST7613_5819	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BEST7613_5820	COG0583	DNA-binding transcription factor activity
BEST7613_5821	COG0126	phosphoglycerate kinase activity
BEST7613_5827	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7613_5827	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BEST7613_5828	COG0802	atpase or kinase
BEST7613_5831	COG2010	Cytochrome c
BEST7613_5835	COG0228	four-way junction DNA binding
BEST7613_5836	COG1253	flavin adenine dinucleotide binding
BEST7613_5840	COG1950	PFAM Membrane protein of
BEST7613_5842	COG3239	Fatty acid desaturase
BEST7613_5850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BEST7613_5852	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BEST7613_5854	COG0025	NhaP-type Na H and K H
BEST7613_5856	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BEST7613_5859	COG2226	methyltransferase
BEST7613_5861	COG0832	Belongs to the urease beta subunit family
BEST7613_5863	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BEST7613_5864	COG1446	asparaginase
BEST7613_5866	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BEST7613_5867	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BEST7613_5871	COG2161	toxin-antitoxin pair type II binding
BEST7613_5877	COG3751	2OG-Fe(II) oxygenase superfamily
BEST7613_5879	COG0497	DNA recombination
BEST7613_5880	COG0426	domain, Protein
BEST7613_5880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7613_5881	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BEST7613_5884	COG2161	toxin-antitoxin pair type II binding
BEST7613_5885	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
BEST7613_5886	COG0390	transport system, permease component
BEST7613_5887	COG0571	ribonuclease III activity
BEST7613_5890	COG0561	phosphatase activity
BEST7613_5891	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7613_5892	COG0572	uridine kinase
BEST7613_5894	COG0542	response to heat
BEST7613_5895	COG0500	methyltransferase
BEST7613_5897	COG0438	transferase activity, transferring glycosyl groups
BEST7613_5900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BEST7613_5903	COG3385	transposase activity
BEST7613_5908	COG0438	transferase activity, transferring glycosyl groups
BEST7613_5910	COG0564	pseudouridine synthase activity
BEST7613_5913	COG1280	lysine exporter protein (LysE YggA)
BEST7613_5914	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BEST7613_5915	COG2816	NAD+ diphosphatase activity
BEST7613_5916	COG1472	Belongs to the glycosyl hydrolase 3 family
BEST7613_5919	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BEST7613_5920	COG0463	Glycosyl transferase, family 2
BEST7613_5921	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BEST7613_5922	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
BEST7613_5925	COG0424	maF-like protein
BEST7613_5926	COG0215	cysteine-tRNA ligase activity
BEST7613_5928	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7613_5929	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BEST7613_5930	COG1366	Belongs to the anti-sigma-factor antagonist family
BEST7613_5931	COG0561	phosphatase activity
BEST7613_5932	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BEST7613_5933	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BEST7613_5937	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BEST7613_5939	COG0488	(ABC) transporter
BEST7613_5943	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7613_5944	COG0431	NADPH-dependent FMN reductase
BEST7613_5945	COG0798	PFAM Bile acid sodium symporter
BEST7613_5947	COG3588	fructose-bisphosphate aldolase
BEST7613_5948	COG0656	L-ascorbic acid biosynthetic process
BEST7613_5950	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BEST7613_5951	COG0612	Peptidase, M16
BEST7613_5952	COG2082	Precorrin-8x methylmutase
BEST7613_5955	COG0157	Belongs to the NadC ModD family
BEST7613_5958	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BEST7613_5959	COG2197	response regulator
BEST7613_5960	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7613_5960	COG0515	serine threonine protein kinase
BEST7613_5961	COG0072	phenylalanine-tRNA ligase activity
BEST7613_5961	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BEST7613_5963	COG0784	Response regulator, receiver
BEST7613_5964	COG2203	Gaf domain
BEST7613_5964	COG5001	Diguanylate cyclase
BEST7613_5964	COG3706	GGDEF domain
BEST7613_5964	COG4251	negative regulation of phosphorylation
BEST7613_5965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7613_5965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BEST7613_5967	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BEST7613_5969	COG0745	RESPONSE REGULATOR receiver
BEST7613_5970	COG1304	FMN binding
BEST7613_5972	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BEST7613_5979	COG3385	transposase activity
BEST7613_5982	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_5988	COG1134	teichoic acid transport
BEST7613_5989	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BEST7613_5990	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BEST7613_5991	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BEST7613_5992	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BEST7613_5995	COG0375	protein maturation
BEST7613_5997	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BEST7613_5998	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BEST7613_6000	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BEST7613_6001	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BEST7613_6006	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7613_6009	COG0386	Belongs to the glutathione peroxidase family
BEST7613_6013	COG0371	Dehydrogenase
BEST7613_6014	COG0644	oxidoreductase
BEST7613_6018	COG0297	glycogen (starch) synthase activity
BEST7613_6019	COG2046	Belongs to the sulfate adenylyltransferase family
BEST7613_6020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BEST7613_6027	COG0698	ribose 5-phosphate isomerase
BEST7613_6029	COG0151	Belongs to the GarS family
BEST7613_6031	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BEST7613_6032	COG0049	tRNA binding
BEST7613_6033	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BEST7613_6034	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BEST7613_6035	COG0051	transcription antitermination factor activity, RNA binding
BEST7613_6037	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BEST7613_6040	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7613_6041	COG1619	proteins homologs of microcin C7 resistance protein MccF
BEST7613_6043	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BEST7613_6044	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BEST7613_6044	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BEST7613_6045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7613_6046	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BEST7613_6049	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BEST7613_6053	COG0259	pyridoxamine-phosphate oxidase activity
BEST7613_6056	COG2204	response regulator
BEST7613_6059	COG0504	CTP synthase activity
BEST7613_6060	COG0066	3-isopropylmalate dehydratase activity
BEST7613_6063	COG0628	permease
BEST7613_6065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BEST7613_6073	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_6074	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_6075	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BEST7613_6076	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BEST7613_6077	COG0037	tRNA processing
BEST7613_6085	COG3659	wide pore channel activity
BEST7613_6088	COG0405	Gamma-glutamyltransferase
BEST7613_6089	COG0772	Belongs to the SEDS family
BEST7613_6091	COG2192	nodulation
BEST7613_6092	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BEST7613_6093	COG2274	protein secretion by the type I secretion system
BEST7613_6094	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7613_6095	COG0723	plastoquinol--plastocyanin reductase activity
BEST7613_6098	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7613_6102	COG2211	Major facilitator Superfamily
BEST7613_6103	COG0300	oxidoreductase activity
BEST7613_6103	COG3000	fatty acid hydroxylase
BEST7613_6105	COG1215	transferase activity, transferring glycosyl groups
BEST7613_6107	COG0540	Belongs to the ATCase OTCase family
BEST7613_6110	COG0791	NLP P60 protein
BEST7613_6111	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BEST7613_6112	COG0483	inositol monophosphate 1-phosphatase activity
BEST7613_6113	COG0484	heat shock protein binding
BEST7613_6115	COG0706	membrane insertase activity
BEST7613_6117	COG0594	ribonuclease P activity
BEST7613_6118	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BEST7613_6120	COG2082	Precorrin-8x methylmutase
BEST7613_6124	COG0589	response to stress
BEST7613_6128	COG0009	L-threonylcarbamoyladenylate synthase
BEST7613_6130	COG0358	DNA primase activity
BEST7613_6131	COG0539	negative regulation of cytoplasmic translation
BEST7613_6133	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BEST7613_6134	COG2208	phosphoserine phosphatase activity
BEST7613_6134	COG2770	Histidine kinase
BEST7613_6135	COG3706	GGDEF domain
BEST7613_6135	COG0745	RESPONSE REGULATOR receiver
BEST7613_6137	COG1316	TRANSCRIPTIONal
BEST7613_6139	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BEST7613_6140	COG5398	heme oxygenase
BEST7613_6141	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BEST7613_6143	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BEST7613_6144	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BEST7613_6146	COG3842	ATPase activity
BEST7613_6147	COG2197	response regulator
BEST7613_6148	COG0432	Pfam Uncharacterised protein family UPF0047
BEST7613_6151	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BEST7613_6153	COG1160	GTP binding
BEST7613_6156	COG4956	integral membrane protein (PIN domain superfamily)
BEST7613_6158	COG3850	Histidine kinase
BEST7613_6158	COG4999	Histidine kinase
BEST7613_6158	COG2205	protein histidine kinase activity
BEST7613_6158	COG3437	response regulator, receiver
BEST7613_6159	COG4783	chaperone-mediated protein folding
BEST7613_6162	COG2202	Pas domain
BEST7613_6162	COG2205	protein histidine kinase activity
BEST7613_6167	COG0107	imidazoleglycerol-phosphate synthase activity
BEST7613_6169	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7613_6169	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BEST7613_6171	COG3631	Ketosteroid isomerase-related protein
BEST7613_6172	COG1716	ATPase activity
BEST7613_6172	COG5001	Diguanylate cyclase
BEST7613_6173	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BEST7613_6184	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BEST7613_6186	COG2267	carboxylic ester hydrolase activity
BEST7613_6187	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BEST7613_6188	COG1113	amino acid transport
BEST7613_6189	COG0367	asparagine synthase
BEST7613_6190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BEST7613_6191	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BEST7613_6193	COG1506	peptidase
BEST7613_6194	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BEST7613_6195	COG1116	anion transmembrane transporter activity
BEST7613_6196	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BEST7613_6197	COG0494	nUDIX hydrolase
BEST7613_6198	COG4824	toxin secretion phage lysis holin
BEST7613_6199	COG0783	Belongs to the Dps family
BEST7613_6202	COG1854	S-ribosylhomocysteine lyase activity
BEST7613_6203	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BEST7613_6204	COG0288	reversible hydration of carbon dioxide
BEST7613_6205	COG0254	rRNA binding
BEST7613_6206	COG1271	oxidase subunit
BEST7613_6207	COG1294	oxidase, subunit
BEST7613_6209	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7613_6210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BEST7613_6210	COG1321	iron dependent repressor
BEST7613_6211	COG1121	(ABC) transporter
BEST7613_6212	COG0803	Belongs to the bacterial solute-binding protein 9 family
BEST7613_6213	COG4948	Mandelate Racemase Muconate Lactonizing
BEST7613_6214	COG0318	PFAM AMP-dependent synthetase and ligase
BEST7613_6215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BEST7613_6216	COG0596	Alpha beta hydrolase
BEST7613_6217	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BEST7613_6218	COG1169	isochorismate synthase
BEST7613_6219	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BEST7613_6220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7613_6221	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7613_6222	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BEST7613_6223	COG0438	transferase activity, transferring glycosyl groups
BEST7613_6225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7613_6226	COG0438	transferase activity, transferring glycosyl groups
BEST7613_6227	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7613_6228	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BEST7613_6229	COG0058	SHG alpha-glucan phosphorylase activity
BEST7613_6230	COG0297	glycogen (starch) synthase activity
BEST7613_6231	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7613_6232	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BEST7613_6233	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BEST7613_6234	COG3859	Proton-coupled thiamine transporter YuaJ
BEST7613_6235	COG1247	-acetyltransferase
BEST7613_6236	COG2268	Band 7 protein
BEST7613_6237	COG1585	Membrane protein implicated in regulation of membrane protease activity
BEST7613_6238	COG2318	DinB family
BEST7613_6240	COG1454	alcohol dehydrogenase
BEST7613_6242	COG1510	regulation of RNA biosynthetic process
BEST7613_6244	COG0569	domain protein
BEST7613_6245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BEST7613_6246	COG4682	membrane
BEST7613_6247	COG1705	Flagellar rod assembly protein muramidase FlgJ
BEST7613_6248	COG0477	Major facilitator Superfamily
BEST7613_6249	COG5553	Cysteine dioxygenase type I
BEST7613_6250	COG1968	undecaprenyl-diphosphatase activity
BEST7613_6251	COG0628	permease
BEST7613_6252	COG0673	inositol 2-dehydrogenase activity
BEST7613_6253	COG4806	L-rhamnose isomerase
BEST7613_6254	COG3254	rhamnose metabolic process
BEST7613_6255	COG1070	Carbohydrate kinase
BEST7613_6256	COG1349	DNA-binding transcription factor activity
BEST7613_6257	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6257	COG3347	Dehydrogenase
BEST7613_6258	COG0840	transmembrane signaling receptor activity
BEST7613_6259	COG0840	transmembrane signaling receptor activity
BEST7613_6260	COG0840	transmembrane signaling receptor activity
BEST7613_6261	COG0840	transmembrane signaling receptor activity
BEST7613_6264	COG0432	Pfam Uncharacterised protein family UPF0047
BEST7613_6265	COG0366	Alpha amylase catalytic
BEST7613_6266	COG1253	flavin adenine dinucleotide binding
BEST7613_6267	COG2738	Putative neutral zinc metallopeptidase
BEST7613_6270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BEST7613_6273	COG0166	Belongs to the GPI family
BEST7613_6274	COG1979	alcohol dehydrogenase
BEST7613_6275	COG1979	alcohol dehydrogenase
BEST7613_6276	COG2155	Conserved Protein
BEST7613_6277	COG1098	S1 RNA binding domain
BEST7613_6278	COG0436	Aminotransferase
BEST7613_6279	COG1522	sequence-specific DNA binding
BEST7613_6280	COG2267	carboxylic ester hydrolase activity
BEST7613_6282	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BEST7613_6283	COG2205	protein histidine kinase activity
BEST7613_6285	COG5018	Exonuclease
BEST7613_6287	COG2814	Major facilitator Superfamily
BEST7613_6288	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7613_6289	COG3011	Protein conserved in bacteria
BEST7613_6291	COG3290	protein histidine kinase activity
BEST7613_6292	COG4565	transcriptional regulatory protein
BEST7613_6297	COG3493	citrate carrier protein
BEST7613_6299	COG2111	Na H antiporter
BEST7613_6299	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BEST7613_6300	COG2111	Na H antiporter
BEST7613_6301	COG1006	Multisubunit Na H antiporter MnhC subunit
BEST7613_6302	COG0651	ATP synthesis coupled electron transport
BEST7613_6303	COG1863	multisubunit Na H antiporter MnhE subunit
BEST7613_6304	COG2212	antiporter activity
BEST7613_6305	COG1320	monovalent cation:proton antiporter activity
BEST7613_6306	COG2050	protein possibly involved in aromatic compounds catabolism
BEST7613_6307	COG2197	response regulator
BEST7613_6308	COG4585	Histidine kinase
BEST7613_6311	COG0142	geranyltranstransferase activity
BEST7613_6314	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BEST7613_6315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BEST7613_6316	COG1335	isochorismatase
BEST7613_6317	COG5506	Protein of unknown function (DUF1694)
BEST7613_6320	COG0628	permease
BEST7613_6323	COG1418	mRNA catabolic process
BEST7613_6324	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6326	COG1511	domain protein
BEST7613_6327	COG0433	COG0433 Predicted ATPase
BEST7613_6327	COG1674	ftsk spoiiie
BEST7613_6328	COG4499	WXG100 protein secretion system (Wss), protein YukC
BEST7613_6329	COG5417	Belongs to the EsaB family
BEST7613_6330	COG4842	Belongs to the WXG100 family
BEST7613_6331	COG2508	Transcriptional regulator
BEST7613_6331	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BEST7613_6332	COG0686	Belongs to the AlaDH PNT family
BEST7613_6333	COG5634	Uncharacterized conserved protein (DUF2278)
BEST7613_6334	COG3251	PFAM MbtH domain protein
BEST7613_6335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_6336	COG1535	isochorismatase
BEST7613_6336	COG3433	isochorismatase activity
BEST7613_6337	COG1021	2,3-dihydroxybenzoate-AMP ligase
BEST7613_6338	COG1169	isochorismate synthase
BEST7613_6339	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6340	COG2819	hydrolase of the alpha beta superfamily
BEST7613_6341	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BEST7613_6342	COG1268	BioY protein
BEST7613_6343	COG2056	Na+-H+ antiporter family
BEST7613_6344	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BEST7613_6345	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BEST7613_6346	COG3584	3D domain protein
BEST7613_6348	COG1252	NADH dehydrogenase
BEST7613_6349	COG0492	ferredoxin-NADP+ reductase activity
BEST7613_6351	COG0516	GMP reductase activity
BEST7613_6352	COG2808	Putative FMN-binding domain
BEST7613_6353	COG0456	acetyltransferase
BEST7613_6354	COG0316	Belongs to the HesB IscA family
BEST7613_6355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BEST7613_6356	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7613_6357	COG4844	belongs to the
BEST7613_6358	COG1252	NADH dehydrogenase
BEST7613_6359	COG4837	Protein of unknown function (DUF1462)
BEST7613_6360	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BEST7613_6361	COG4946	Tricorn protease homolog
BEST7613_6361	COG1506	peptidase
BEST7613_6361	COG0823	Involved in the tonB-independent uptake of proteins
BEST7613_6362	COG0083	homoserine kinase activity
BEST7613_6363	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BEST7613_6364	COG0460	homoserine dehydrogenase
BEST7613_6365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BEST7613_6366	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BEST7613_6367	COG0647	UMP catabolic process
BEST7613_6368	COG2445	Protein of unknown function DUF86
BEST7613_6369	COG4470	Protein conserved in bacteria
BEST7613_6371	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BEST7613_6372	COG0739	heme binding
BEST7613_6374	COG3377	Domain of unknown function (DUF1805)
BEST7613_6375	COG0737	Belongs to the 5'-nucleotidase family
BEST7613_6376	COG0730	response to heat
BEST7613_6377	COG1801	Protein of unknown function DUF72
BEST7613_6379	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BEST7613_6380	COG2508	Transcriptional regulator
BEST7613_6381	COG2233	PERMEase
BEST7613_6382	COG2233	PERMEase
BEST7613_6383	COG3195	allantoin biosynthetic process
BEST7613_6383	COG3648	Uricase
BEST7613_6384	COG2351	hydroxyisourate hydrolase activity
BEST7613_6386	COG2080	2 iron, 2 sulfur cluster binding
BEST7613_6387	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BEST7613_6388	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BEST7613_6389	COG2068	MobA-Related Protein
BEST7613_6390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BEST7613_6391	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BEST7613_6392	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BEST7613_6393	COG2356	endonuclease I
BEST7613_6394	COG3842	ATPase activity
BEST7613_6395	COG2188	Transcriptional regulator
BEST7613_6396	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7613_6397	COG0395	ABC-type sugar transport system, permease component
BEST7613_6398	COG1175	transmembrane transport
BEST7613_6399	COG1653	transport
BEST7613_6400	COG2222	sugar isomerase
BEST7613_6401	COG0322	excinuclease ABC activity
BEST7613_6402	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BEST7613_6405	COG0346	lactoylglutathione lyase activity
BEST7613_6406	COG0640	Transcriptional regulator
BEST7613_6407	COG0719	Fe-S assembly protein
BEST7613_6408	COG0822	iron-sulfur transferase activity
BEST7613_6409	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BEST7613_6410	COG0719	Fe-S assembly protein
BEST7613_6411	COG0396	ATPase activity
BEST7613_6413	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BEST7613_6414	COG1464	Belongs to the NlpA lipoprotein family
BEST7613_6415	COG2011	ABC-type metal ion transport system permease component
BEST7613_6416	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BEST7613_6418	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BEST7613_6419	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BEST7613_6421	COG0509	glycine decarboxylation via glycine cleavage system
BEST7613_6422	COG1393	Belongs to the ArsC family
BEST7613_6423	COG1960	acyl-CoA dehydrogenase activity
BEST7613_6424	COG0183	Belongs to the thiolase family
BEST7613_6425	COG1250	3-hydroxyacyl-CoA dehydrogenase
BEST7613_6425	COG1024	Enoyl-CoA hydratase
BEST7613_6427	COG0506	proline dehydrogenase activity
BEST7613_6429	COG5577	PFAM Coat F domain
BEST7613_6430	COG1846	Transcriptional regulator
BEST7613_6431	COG0477	Major facilitator Superfamily
BEST7613_6432	COG1942	4-Oxalocrotonate Tautomerase
BEST7613_6433	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6434	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6435	COG0583	DNA-binding transcription factor activity
BEST7613_6437	COG1120	ATPase activity
BEST7613_6441	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6442	COG0783	Belongs to the Dps family
BEST7613_6443	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7613_6444	COG0745	RESPONSE REGULATOR receiver
BEST7613_6445	COG2205	protein histidine kinase activity
BEST7613_6445	COG2770	Histidine kinase
BEST7613_6447	COG1309	transcriptional regulator
BEST7613_6448	COG0114	fumarate hydratase activity
BEST7613_6450	COG0697	spore germination
BEST7613_6451	COG0814	amino acid
BEST7613_6453	COG2197	response regulator
BEST7613_6454	COG4585	Histidine kinase
BEST7613_6455	COG4758	membrane
BEST7613_6456	COG3595	metallopeptidase activity
BEST7613_6457	COG1842	Phage shock protein A
BEST7613_6458	COG4758	membrane
BEST7613_6459	COG2814	Major facilitator Superfamily
BEST7613_6460	COG2096	Adenosyltransferase
BEST7613_6461	COG1120	ATPase activity
BEST7613_6462	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_6463	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_6464	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6465	COG3386	PFAM SMP-30 Gluconolaconase
BEST7613_6466	COG2205	protein histidine kinase activity
BEST7613_6467	COG0745	RESPONSE REGULATOR receiver
BEST7613_6469	COG1191	sigma factor activity
BEST7613_6471	COG2140	Oxalate decarboxylase
BEST7613_6473	COG0577	efflux transmembrane transporter activity
BEST7613_6474	COG1136	(ABC) transporter
BEST7613_6475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BEST7613_6476	COG1120	ATPase activity
BEST7613_6477	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_6478	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BEST7613_6479	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_6480	COG0531	amino acid
BEST7613_6482	COG1988	membrane-bound metal-dependent
BEST7613_6483	COG1368	sulfuric ester hydrolase activity
BEST7613_6484	COG1910	domain protein
BEST7613_6485	COG0725	ABC transporter, periplasmic molybdate-binding protein
BEST7613_6486	COG4149	molybdate abc transporter
BEST7613_6487	COG0656	L-ascorbic acid biosynthetic process
BEST7613_6489	COG0025	NhaP-type Na H and K H
BEST7613_6490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BEST7613_6491	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BEST7613_6492	COG3973	AAA domain
BEST7613_6493	COG2860	membrane
BEST7613_6494	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BEST7613_6495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BEST7613_6496	COG2217	Heavy metal translocating P-type atpase
BEST7613_6497	COG2217	Heavy metal translocating P-type atpase
BEST7613_6498	COG2608	mercury ion transmembrane transporter activity
BEST7613_6499	COG1937	Protein conserved in bacteria
BEST7613_6500	COG0673	inositol 2-dehydrogenase activity
BEST7613_6501	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BEST7613_6502	COG1289	transmembrane transporter activity
BEST7613_6504	COG2076	Multidrug Resistance protein
BEST7613_6505	COG1309	transcriptional regulator
BEST7613_6506	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6507	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BEST7613_6508	COG0557	exoribonuclease II activity
BEST7613_6509	COG1647	Serine aminopeptidase, S33
BEST7613_6510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BEST7613_6511	COG0596	Alpha beta hydrolase
BEST7613_6512	COG1476	TRANSCRIPTIONal
BEST7613_6513	COG1396	sequence-specific DNA binding
BEST7613_6514	COG1396	sequence-specific DNA binding
BEST7613_6515	COG1733	regulation of RNA biosynthetic process
BEST7613_6516	COG0840	transmembrane signaling receptor activity
BEST7613_6517	COG1174	glycine betaine transport
BEST7613_6518	COG1732	Glycine betaine
BEST7613_6519	COG1174	glycine betaine transport
BEST7613_6520	COG0517	IMP dehydrogenase activity
BEST7613_6520	COG1125	glycine betaine transport
BEST7613_6521	COG1510	regulation of RNA biosynthetic process
BEST7613_6525	COG5658	integral membrane protein
BEST7613_6526	COG0640	Transcriptional regulator
BEST7613_6527	COG1174	glycine betaine transport
BEST7613_6528	COG1732	Glycine betaine
BEST7613_6529	COG1174	glycine betaine transport
BEST7613_6530	COG1125	glycine betaine transport
BEST7613_6530	COG0517	IMP dehydrogenase activity
BEST7613_6531	COG1510	regulation of RNA biosynthetic process
BEST7613_6532	COG2095	MarC family integral membrane protein
BEST7613_6534	COG3064	Membrane
BEST7613_6535	COG4640	response to antibiotic
BEST7613_6536	COG0456	acetyltransferase
BEST7613_6537	COG0148	phosphopyruvate hydratase activity
BEST7613_6538	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BEST7613_6539	COG0149	triose-phosphate isomerase activity
BEST7613_6540	COG0126	phosphoglycerate kinase activity
BEST7613_6541	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BEST7613_6542	COG2390	Transcriptional regulator
BEST7613_6543	COG2814	Major facilitator Superfamily
BEST7613_6544	COG1609	Transcriptional regulator
BEST7613_6545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7613_6546	COG0583	DNA-binding transcription factor activity
BEST7613_6547	COG0697	spore germination
BEST7613_6548	COG1113	amino acid transport
BEST7613_6549	COG3858	chitin binding
BEST7613_6550	COG1556	Lactate utilization protein
BEST7613_6551	COG1139	Iron-sulfur cluster binding protein
BEST7613_6552	COG0247	lactate metabolic process
BEST7613_6553	COG2197	response regulator
BEST7613_6554	COG4585	Histidine kinase
BEST7613_6555	COG0842	Transport permease protein
BEST7613_6556	COG1131	(ABC) transporter
BEST7613_6557	COG0596	Alpha beta hydrolase
BEST7613_6558	COG2208	phosphoserine phosphatase activity
BEST7613_6559	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BEST7613_6560	COG1874	Beta-galactosidase
BEST7613_6561	COG3833	ABC-type maltose transport systems, permease component
BEST7613_6562	COG1175	transmembrane transport
BEST7613_6563	COG2182	Extracellular solute-binding protein
BEST7613_6564	COG1609	Transcriptional regulator
BEST7613_6565	COG2186	Transcriptional regulator
BEST7613_6566	COG1620	l-lactate permease
BEST7613_6567	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BEST7613_6569	COG5039	Polysaccharide pyruvyl transferase
BEST7613_6570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7613_6571	COG0110	maltose O-acetyltransferase activity
BEST7613_6572	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BEST7613_6576	COG0438	transferase activity, transferring glycosyl groups
BEST7613_6577	COG1215	transferase activity, transferring glycosyl groups
BEST7613_6578	COG0438	transferase activity, transferring glycosyl groups
BEST7613_6579	COG1086	Polysaccharide biosynthesis protein
BEST7613_6580	COG0489	protein tyrosine kinase activity
BEST7613_6581	COG3944	biosynthesis protein
BEST7613_6582	COG1396	sequence-specific DNA binding
BEST7613_6583	COG2272	Belongs to the type-B carboxylesterase lipase family
BEST7613_6585	COG3479	Phenolic acid decarboxylase
BEST7613_6587	COG1794	racemase activity, acting on amino acids and derivatives
BEST7613_6588	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BEST7613_6589	COG1621	beta-fructofuranosidase activity
BEST7613_6590	COG1621	beta-fructofuranosidase activity
BEST7613_6591	COG0531	amino acid
BEST7613_6592	COG1309	transcriptional regulator
BEST7613_6593	COG2076	Multidrug Resistance protein
BEST7613_6594	COG2076	Multidrug Resistance protein
BEST7613_6596	COG0277	FAD linked oxidase domain protein
BEST7613_6597	COG3621	Patatin-like phospholipase
BEST7613_6598	COG0740	serine-type endopeptidase activity
BEST7613_6599	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BEST7613_6600	COG0366	Alpha amylase catalytic
BEST7613_6601	COG1554	hydrolase, family 65, central catalytic
BEST7613_6602	COG5521	maltodextrose utilization protein MalA
BEST7613_6603	COG3833	ABC-type maltose transport systems, permease component
BEST7613_6604	COG1175	transmembrane transport
BEST7613_6605	COG2182	Extracellular solute-binding protein
BEST7613_6606	COG0366	Alpha amylase catalytic
BEST7613_6607	COG1609	Transcriptional regulator
BEST7613_6608	COG1611	Belongs to the LOG family
BEST7613_6609	COG1694	Mazg nucleotide pyrophosphohydrolase
BEST7613_6610	COG0659	secondary active sulfate transmembrane transporter activity
BEST7613_6611	COG0288	reversible hydration of carbon dioxide
BEST7613_6612	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BEST7613_6613	COG0577	efflux transmembrane transporter activity
BEST7613_6614	COG1136	(ABC) transporter
BEST7613_6615	COG5002	protein histidine kinase activity
BEST7613_6616	COG0745	RESPONSE REGULATOR receiver
BEST7613_6618	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BEST7613_6619	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_6620	COG1481	regulation of sporulation
BEST7613_6621	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BEST7613_6622	COG1660	Displays ATPase and GTPase activities
BEST7613_6623	COG1051	belongs to the nudix hydrolase family
BEST7613_6624	COG0492	ferredoxin-NADP+ reductase activity
BEST7613_6625	COG0791	NLP P60 protein
BEST7613_6625	COG3883	PFAM NLP P60 protein
BEST7613_6626	COG0457	Tetratricopeptide repeat
BEST7613_6627	COG1132	(ABC) transporter
BEST7613_6631	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BEST7613_6631	COG0140	phosphoribosyl-ATP diphosphatase activity
BEST7613_6632	COG0107	imidazoleglycerol-phosphate synthase activity
BEST7613_6633	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BEST7613_6634	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BEST7613_6635	COG0131	Imidazoleglycerol-phosphate dehydratase
BEST7613_6636	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BEST7613_6637	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BEST7613_6638	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BEST7613_6639	COG4990	cell redox homeostasis
BEST7613_6640	COG5297	Belongs to the glycosyl hydrolase family 6
BEST7613_6641	COG0110	maltose O-acetyltransferase activity
BEST7613_6642	COG0546	phosphoglycolate phosphatase activity
BEST7613_6643	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BEST7613_6644	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BEST7613_6645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BEST7613_6646	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BEST7613_6647	COG0363	glucosamine-6-phosphate deaminase activity
BEST7613_6649	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BEST7613_6650	COG1846	Transcriptional regulator
BEST7613_6651	COG2124	cytochrome p450
BEST7613_6653	COG1846	Transcriptional regulator
BEST7613_6654	COG2814	Major facilitator Superfamily
BEST7613_6655	COG1950	PFAM Membrane protein of
BEST7613_6656	COG1983	PspC domain protein
BEST7613_6657	COG3595	metallopeptidase activity
BEST7613_6660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7613_6661	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BEST7613_6662	COG0556	nucleotide-excision repair
BEST7613_6663	COG4897	Protein conserved in bacteria
BEST7613_6664	COG0574	Belongs to the PEP-utilizing enzyme family
BEST7613_6664	COG3848	Pyruvate phosphate dikinase
BEST7613_6665	COG1309	transcriptional regulator
BEST7613_6666	COG2814	Major facilitator Superfamily
BEST7613_6667	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7613_6669	COG3409	Peptidoglycan-binding domain 1 protein
BEST7613_6669	COG0793	Belongs to the peptidase S41A family
BEST7613_6670	COG2177	Part of the ABC transporter FtsEX involved in
BEST7613_6671	COG2884	Cell division ATP-binding protein ftsE
BEST7613_6672	COG2010	Cytochrome c
BEST7613_6673	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7613_6674	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BEST7613_6675	COG0653	protein targeting
BEST7613_6676	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BEST7613_6679	COG1516	flagellar protein fliS
BEST7613_6680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BEST7613_6681	COG1334	flagellar protein FlaG
BEST7613_6682	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7613_6683	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BEST7613_6684	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BEST7613_6686	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BEST7613_6687	COG1256	bacterial-type flagellum assembly
BEST7613_6687	COG4786	Flagellar basal body rod
BEST7613_6688	COG3418	PFAM FlgN family protein
BEST7613_6689	COG2747	anti-sigma28 factor FlgM
BEST7613_6691	COG1040	competence protein
BEST7613_6693	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BEST7613_6694	COG1307	EDD domain protein, DegV family
BEST7613_6695	COG2197	response regulator
BEST7613_6696	COG4585	Histidine kinase
BEST7613_6697	COG1739	Uncharacterized protein family UPF0029
BEST7613_6698	COG1316	TRANSCRIPTIONal
BEST7613_6699	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BEST7613_6700	COG0438	transferase activity, transferring glycosyl groups
BEST7613_6701	COG1215	transferase activity, transferring glycosyl groups
BEST7613_6702	COG3206	protein involved in exopolysaccharide biosynthesis
BEST7613_6703	COG3307	-O-antigen
BEST7613_6704	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7613_6705	COG0297	glycogen (starch) synthase activity
BEST7613_6705	COG0438	transferase activity, transferring glycosyl groups
BEST7613_6706	COG2244	polysaccharide biosynthetic process
BEST7613_6708	COG0860	N-Acetylmuramoyl-L-alanine amidase
BEST7613_6708	COG2247	cell wall binding repeat
BEST7613_6709	COG2385	sporulation resulting in formation of a cellular spore
BEST7613_6709	COG2247	cell wall binding repeat
BEST7613_6711	COG1316	TRANSCRIPTIONal
BEST7613_6712	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BEST7613_6713	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7613_6714	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7613_6714	COG1215	transferase activity, transferring glycosyl groups
BEST7613_6715	COG0463	Glycosyl transferase, family 2
BEST7613_6717	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BEST7613_6718	COG1134	teichoic acid transport
BEST7613_6719	COG1682	transport, permease protein
BEST7613_6720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7613_6721	COG0438	transferase activity, transferring glycosyl groups
BEST7613_6722	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BEST7613_6723	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BEST7613_6724	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7613_6726	COG4193	domain, Protein
BEST7613_6727	COG1482	cell wall glycoprotein biosynthetic process
BEST7613_6728	COG0697	spore germination
BEST7613_6729	COG0814	amino acid
BEST7613_6731	COG2814	Major facilitator Superfamily
BEST7613_6732	COG1316	TRANSCRIPTIONal
BEST7613_6733	COG0561	phosphatase activity
BEST7613_6734	COG0791	NLP P60 protein
BEST7613_6736	COG2843	Capsule synthesis protein
BEST7613_6738	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BEST7613_6739	COG1609	Transcriptional regulator
BEST7613_6740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7613_6741	COG1869	D-ribose catabolic process
BEST7613_6742	COG1129	ABC transporter
BEST7613_6743	COG1172	Belongs to the binding-protein-dependent transport system permease family
BEST7613_6744	COG1879	ABC-type sugar transport system periplasmic component
BEST7613_6745	COG3103	Sh3 type 3 domain protein
BEST7613_6747	COG2249	NAD(P)H dehydrogenase (quinone) activity
BEST7613_6748	COG3527	Alpha-acetolactate decarboxylase
BEST7613_6749	COG0028	Belongs to the TPP enzyme family
BEST7613_6750	COG0583	DNA-binding transcription factor activity
BEST7613_6751	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BEST7613_6754	COG5337	Spore coat protein CotH
BEST7613_6756	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BEST7613_6758	COG0405	Gamma-glutamyltransferase
BEST7613_6759	COG1522	sequence-specific DNA binding
BEST7613_6760	COG2059	Chromate
BEST7613_6761	COG2059	Chromate
BEST7613_6763	COG0655	NAD(P)H dehydrogenase (quinone) activity
BEST7613_6764	COG0583	DNA-binding transcription factor activity
BEST7613_6765	COG1515	deoxyribonuclease V activity
BEST7613_6766	COG2849	repeat protein
BEST7613_6767	COG5444	nuclease activity
BEST7613_6770	COG3878	Protein conserved in bacteria
BEST7613_6771	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BEST7613_6772	COG4464	protein tyrosine phosphatase activity
BEST7613_6773	COG0489	protein tyrosine kinase activity
BEST7613_6774	COG3944	biosynthesis protein
BEST7613_6776	COG4715	Zinc finger, swim domain protein
BEST7613_6777	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BEST7613_6778	COG0561	phosphatase activity
BEST7613_6779	COG1349	DNA-binding transcription factor activity
BEST7613_6780	COG0629	single-stranded DNA binding
BEST7613_6783	COG3764	Sortase (surface protein transpeptidase)
BEST7613_6785	COG0745	RESPONSE REGULATOR receiver
BEST7613_6785	COG2972	Histidine kinase
BEST7613_6786	COG1970	mechanosensitive ion channel activity
BEST7613_6787	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BEST7613_6788	COG0457	Tetratricopeptide repeat
BEST7613_6789	COG4786	Flagellar basal body rod
BEST7613_6790	COG4786	Flagellar basal body rod
BEST7613_6791	COG1077	Cell shape determining protein MreB Mrl
BEST7613_6792	COG1609	Transcriptional regulator
BEST7613_6793	COG1846	Transcriptional regulator
BEST7613_6794	COG2814	Major facilitator Superfamily
BEST7613_6795	COG3420	alginic acid biosynthetic process
BEST7613_6796	COG1953	Uracil, thiamine, allantoin
BEST7613_6797	COG0477	Major facilitator Superfamily
BEST7613_6798	COG1335	isochorismatase
BEST7613_6800	COG0004	ammonium transporteR
BEST7613_6801	COG0347	Belongs to the P(II) protein family
BEST7613_6802	COG0671	phosphoesterase, PA-phosphatase related
BEST7613_6804	COG0739	heme binding
BEST7613_6805	COG1247	-acetyltransferase
BEST7613_6808	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7613_6809	COG0789	Transcriptional regulator
BEST7613_6811	COG2910	NAD(P)H-binding
BEST7613_6812	COG1959	2 iron, 2 sulfur cluster binding
BEST7613_6813	COG0804	urea catabolic process
BEST7613_6814	COG0832	Belongs to the urease beta subunit family
BEST7613_6815	COG0831	urea catabolic process
BEST7613_6818	COG3237	CsbD-like
BEST7613_6819	COG1994	Peptidase M50
BEST7613_6820	COG0457	Tetratricopeptide repeat
BEST7613_6821	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BEST7613_6822	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BEST7613_6824	COG2304	oxidoreductase activity
BEST7613_6825	COG2304	oxidoreductase activity
BEST7613_6827	COG2385	sporulation resulting in formation of a cellular spore
BEST7613_6828	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BEST7613_6830	COG4836	Membrane
BEST7613_6832	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BEST7613_6833	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BEST7613_6834	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BEST7613_6835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BEST7613_6836	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BEST7613_6837	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BEST7613_6838	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BEST7613_6839	COG0356	it plays a direct role in the translocation of protons across the membrane
BEST7613_6841	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BEST7613_6842	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BEST7613_6843	COG4475	Protein of unknown function (DUF436)
BEST7613_6844	COG0698	ribose 5-phosphate isomerase
BEST7613_6845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BEST7613_6846	COG1971	Probably functions as a manganese efflux pump
BEST7613_6847	COG0009	L-threonylcarbamoyladenylate synthase
BEST7613_6848	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BEST7613_6852	COG2890	protein-(glutamine-N5) methyltransferase activity
BEST7613_6853	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BEST7613_6854	COG0346	lactoylglutathione lyase activity
BEST7613_6855	COG0789	Transcriptional regulator
BEST7613_6856	COG0679	Auxin Efflux Carrier
BEST7613_6857	COG0281	malic enzyme
BEST7613_6858	COG1435	thymidine kinase activity
BEST7613_6859	COG0254	rRNA binding
BEST7613_6860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BEST7613_6861	COG1494	fructose-1,6-bisphosphatase
BEST7613_6862	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BEST7613_6863	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BEST7613_6864	COG0191	fructose-bisphosphate aldolase activity
BEST7613_6865	COG2204	response regulator
BEST7613_6866	COG4821	SIS domain
BEST7613_6867	COG0504	CTP synthase activity
BEST7613_6868	COG3343	RNA polymerase activity
BEST7613_6869	COG1960	acyl-CoA dehydrogenase activity
BEST7613_6870	COG0247	lactate metabolic process
BEST7613_6870	COG2181	nitrate reductase activity
BEST7613_6871	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7613_6872	COG4294	response to UV
BEST7613_6874	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7613_6875	COG1132	(ABC) transporter
BEST7613_6876	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BEST7613_6877	COG2181	nitrate reductase activity
BEST7613_6878	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BEST7613_6879	COG1140	nitrate reductase beta subunit
BEST7613_6880	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BEST7613_6881	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7613_6883	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BEST7613_6884	COG2223	nitrite transmembrane transporter activity
BEST7613_6885	COG0018	arginyl-trna synthetase
BEST7613_6886	COG4506	Protein conserved in bacteria
BEST7613_6888	COG0535	radical SAM domain protein
BEST7613_6890	COG1131	(ABC) transporter
BEST7613_6891	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BEST7613_6892	COG0612	Peptidase, M16
BEST7613_6893	COG0612	Peptidase, M16
BEST7613_6895	COG3391	amine dehydrogenase activity
BEST7613_6896	COG3391	amine dehydrogenase activity
BEST7613_6897	COG0457	Tetratricopeptide repeat
BEST7613_6899	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BEST7613_6900	COG0010	Belongs to the arginase family
BEST7613_6901	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BEST7613_6902	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BEST7613_6904	COG1994	Peptidase M50
BEST7613_6905	COG1942	4-Oxalocrotonate Tautomerase
BEST7613_6906	COG1846	Transcriptional regulator
BEST7613_6907	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BEST7613_6908	COG0477	Major facilitator Superfamily
BEST7613_6909	COG1959	2 iron, 2 sulfur cluster binding
BEST7613_6910	COG3465	dGTPase activity
BEST7613_6911	COG1078	dGTPase activity
BEST7613_6912	COG4844	belongs to the
BEST7613_6914	COG0697	spore germination
BEST7613_6915	COG0095	Lipoate-protein ligase
BEST7613_6916	COG0583	DNA-binding transcription factor activity
BEST7613_6917	COG0280	phosphate acetyltransferase
BEST7613_6919	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6920	COG0436	Aminotransferase
BEST7613_6921	COG2814	Major facilitator Superfamily
BEST7613_6922	COG0151	Belongs to the GarS family
BEST7613_6923	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_6924	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_6925	COG0077	Prephenate dehydratase
BEST7613_6926	COG2814	Major facilitator Superfamily
BEST7613_6927	COG0833	amino acid
BEST7613_6928	COG4187	Peptidase family M20/M25/M40
BEST7613_6929	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_6930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BEST7613_6932	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BEST7613_6933	COG1091	dTDP-4-dehydrorhamnose reductase activity
BEST7613_6934	COG1088	dTDP-glucose 4,6-dehydratase activity
BEST7613_6935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BEST7613_6936	COG3980	spore coat polysaccharide biosynthesis protein
BEST7613_6937	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BEST7613_6938	COG2089	acid synthase
BEST7613_6939	COG0456	acetyltransferase
BEST7613_6940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BEST7613_6941	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BEST7613_6942	COG0463	Glycosyl transferase, family 2
BEST7613_6944	COG2363	Small membrane protein
BEST7613_6945	COG2233	PERMEase
BEST7613_6947	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_6948	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BEST7613_6949	COG1216	Glycosyl transferase, family 2
BEST7613_6952	COG1695	Transcriptional regulator
BEST7613_6953	COG0351	phosphomethylpyrimidine kinase
BEST7613_6955	COG1621	beta-fructofuranosidase activity
BEST7613_6956	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_6956	COG1263	PTS System
BEST7613_6957	COG2116	formate transmembrane transporter activity
BEST7613_6958	COG3711	transcriptional antiterminator
BEST7613_6960	COG1404	Belongs to the peptidase S8 family
BEST7613_6961	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BEST7613_6962	COG0778	Nitroreductase
BEST7613_6963	COG0772	Belongs to the SEDS family
BEST7613_6965	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BEST7613_6966	COG1845	cytochrome c oxidase, subunit III
BEST7613_6967	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BEST7613_6968	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BEST7613_6969	COG2261	transglycosylase associated protein
BEST7613_6970	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BEST7613_6971	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BEST7613_6972	COG2246	polysaccharide biosynthetic process
BEST7613_6973	COG1309	transcriptional regulator
BEST7613_6975	COG3162	membrane
BEST7613_6976	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BEST7613_6977	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BEST7613_6978	COG2837	iron assimilation
BEST7613_6979	COG2822	iron ion transport
BEST7613_6980	COG0672	)-iron permease
BEST7613_6981	COG0352	thiamine-phosphate diphosphorylase activity
BEST7613_6982	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BEST7613_6983	COG0583	DNA-binding transcription factor activity
BEST7613_6984	COG1380	Effector of murein hydrolase LrgA
BEST7613_6985	COG1346	cytolysis
BEST7613_6986	COG2814	Major facilitator Superfamily
BEST7613_6987	COG4895	conserved protein (DUF2196)
BEST7613_6988	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BEST7613_6989	COG0346	lactoylglutathione lyase activity
BEST7613_6991	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7613_6992	COG1404	Belongs to the peptidase S8 family
BEST7613_6993	COG1263	PTS System
BEST7613_6993	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_6994	COG3711	transcriptional antiterminator
BEST7613_6995	COG1442	glycosyl transferase family 8
BEST7613_6996	COG5522	Integral membrane protein (intg_mem_TP0381)
BEST7613_6997	COG1846	Transcriptional regulator
BEST7613_6998	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BEST7613_6999	COG2234	aminopeptidase activity
BEST7613_7000	COG2357	RelA SpoT domain protein
BEST7613_7001	COG1575	Belongs to the MenA family. Type 1 subfamily
BEST7613_7002	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BEST7613_7003	COG1696	Membrane protein involved in D-alanine export
BEST7613_7004	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BEST7613_7005	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BEST7613_7006	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BEST7613_7007	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BEST7613_7008	COG1486	melibiose metabolic process
BEST7613_7009	COG1447	Phosphotransferase system cellobiose-specific component IIA
BEST7613_7010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7613_7011	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BEST7613_7012	COG3711	transcriptional antiterminator
BEST7613_7012	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BEST7613_7014	COG2094	Belongs to the DNA glycosylase MPG family
BEST7613_7015	COG0753	catalase activity
BEST7613_7016	COG2814	Major facilitator Superfamily
BEST7613_7017	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BEST7613_7018	COG1131	(ABC) transporter
BEST7613_7022	COG1595	DNA-templated transcription, initiation
BEST7613_7023	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BEST7613_7024	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BEST7613_7025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BEST7613_7026	COG4988	ABC transporter
BEST7613_7027	COG1294	oxidase, subunit
BEST7613_7028	COG1271	oxidase subunit
BEST7613_7029	COG3493	citrate carrier protein
BEST7613_7030	COG0501	Belongs to the peptidase M48B family
BEST7613_7032	COG0726	polysaccharide deacetylase
BEST7613_7033	COG3842	ATPase activity
BEST7613_7034	COG2508	Transcriptional regulator
BEST7613_7035	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_7036	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BEST7613_7038	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BEST7613_7039	COG1881	PFAM PEBP family protein
BEST7613_7040	COG0583	DNA-binding transcription factor activity
BEST7613_7042	COG4585	Histidine kinase
BEST7613_7043	COG2197	response regulator
BEST7613_7044	COG2195	Cleaves the N-terminal amino acid of tripeptides
BEST7613_7046	COG4894	glucomannan catabolic process
BEST7613_7047	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7613_7048	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BEST7613_7049	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_7050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BEST7613_7051	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BEST7613_7052	COG2610	gluconate transmembrane transporter activity
BEST7613_7053	COG0500	methyltransferase
BEST7613_7054	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7613_7058	COG0693	protein deglycase activity
BEST7613_7058	COG0753	catalase activity
BEST7613_7059	COG2851	Citrate transporter
BEST7613_7060	COG2273	Hydrolase Family 16
BEST7613_7061	COG3711	transcriptional antiterminator
BEST7613_7063	COG2270	Major facilitator Superfamily
BEST7613_7064	COG0513	Belongs to the DEAD box helicase family
BEST7613_7065	COG2755	lipolytic protein G-D-S-L family
BEST7613_7065	COG3401	FG-GAP repeat protein
BEST7613_7077	COG3209	COG3209 Rhs family protein
BEST7613_7078	COG0697	spore germination
BEST7613_7079	COG0589	response to stress
BEST7613_7080	COG2723	6-phospho-beta-galactosidase activity
BEST7613_7081	COG2190	(PTS) system
BEST7613_7081	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BEST7613_7081	COG1263	PTS System
BEST7613_7084	COG5444	nuclease activity
BEST7613_7087	COG3507	Belongs to the glycosyl hydrolase 43 family
BEST7613_7090	COG2986	histidine ammonia-lyase
BEST7613_7091	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BEST7613_7092	COG1228	amidohydrolase
BEST7613_7093	COG0010	Belongs to the arginase family
BEST7613_7094	COG0833	amino acid
BEST7613_7095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BEST7613_7096	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BEST7613_7097	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BEST7613_7098	COG2390	Transcriptional regulator
BEST7613_7100	COG3192	ethanolamine utilization protein
BEST7613_7101	COG2079	MmgE PrpD family protein
BEST7613_7103	COG1126	abc transporter atp-binding protein
BEST7613_7104	COG0765	amino acid transport
BEST7613_7105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BEST7613_7109	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BEST7613_7110	COG0561	phosphatase activity
BEST7613_7116	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BEST7613_7117	COG5294	Protein conserved in bacteria
BEST7613_7118	COG0577	efflux transmembrane transporter activity
BEST7613_7119	COG1136	(ABC) transporter
BEST7613_7120	COG2205	protein histidine kinase activity
BEST7613_7121	COG0745	RESPONSE REGULATOR receiver
BEST7613_7122	COG0191	fructose-bisphosphate aldolase activity
BEST7613_7123	COG1082	Xylose isomerase domain protein TIM barrel
BEST7613_7124	COG1082	Xylose isomerase domain protein TIM barrel
BEST7613_7125	COG0673	inositol 2-dehydrogenase activity
BEST7613_7126	COG2814	Major facilitator Superfamily
BEST7613_7127	COG1082	Xylose isomerase domain protein TIM barrel
BEST7613_7128	COG3962	Belongs to the TPP enzyme family
BEST7613_7129	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BEST7613_7130	COG3718	enzyme involved in inositol metabolism
BEST7613_7131	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_7132	COG1349	DNA-binding transcription factor activity
BEST7613_7133	COG0667	Aldo Keto reductase
BEST7613_7137	COG2814	Major facilitator Superfamily
BEST7613_7138	COG0326	Molecular chaperone. Has ATPase activity
BEST7613_7140	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_7141	COG1309	transcriptional regulator
BEST7613_7142	COG1012	belongs to the aldehyde dehydrogenase family
BEST7613_7143	COG0456	acetyltransferase
BEST7613_7144	COG2850	peptidyl-arginine hydroxylation
BEST7613_7145	COG2226	methyltransferase
BEST7613_7148	COG0367	asparagine synthase
BEST7613_7149	COG2814	Major facilitator Superfamily
BEST7613_7150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BEST7613_7152	COG1714	RDD family
BEST7613_7153	COG2311	Membrane
BEST7613_7154	COG1917	Cupin 2, conserved barrel domain protein
BEST7613_7155	COG1309	transcriptional regulator
BEST7613_7156	COG1028	Short-chain dehydrogenase reductase Sdr
BEST7613_7157	COG1846	Transcriptional regulator
BEST7613_7158	COG1380	Effector of murein hydrolase LrgA
BEST7613_7159	COG1346	cytolysis
BEST7613_7160	COG5039	Polysaccharide pyruvyl transferase
BEST7613_7161	COG1929	Belongs to the glycerate kinase type-1 family
BEST7613_7162	COG1802	Transcriptional regulator
BEST7613_7163	COG1070	Carbohydrate kinase
BEST7613_7164	COG2610	gluconate transmembrane transporter activity
BEST7613_7165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BEST7613_7166	COG0450	alkyl hydroperoxide reductase
BEST7613_7167	COG3634	alkyl hydroperoxide reductase activity
BEST7613_7168	COG2723	6-phospho-beta-galactosidase activity
BEST7613_7169	COG2190	(PTS) system
BEST7613_7170	COG2188	Transcriptional regulator
BEST7613_7173	COG1131	(ABC) transporter
BEST7613_7174	COG1994	Peptidase M50
BEST7613_7175	COG0535	radical SAM domain protein
BEST7613_7177	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BEST7613_7178	COG5293	efflux transmembrane transporter activity
BEST7613_7180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BEST7613_7181	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BEST7613_7184	COG1063	alcohol dehydrogenase
BEST7613_7188	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BEST7613_7189	COG0456	acetyltransferase
BEST7613_7190	COG0457	Tetratricopeptide repeat
BEST7613_7191	COG0010	Belongs to the arginase family
BEST7613_7192	COG0833	amino acid
BEST7613_7193	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BEST7613_7194	COG3829	transcription factor binding
BEST7613_7195	COG5002	protein histidine kinase activity
BEST7613_7196	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BEST7613_7197	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BEST7613_7198	COG4853	Protein conserved in bacteria
BEST7613_7199	COG4863	YycH protein
BEST7613_7200	COG5002	protein histidine kinase activity
BEST7613_7201	COG0745	RESPONSE REGULATOR receiver
BEST7613_7203	COG0346	lactoylglutathione lyase activity
BEST7613_7204	COG0305	Participates in initiation and elongation during chromosome replication
BEST7613_7207	COG3093	addiction module antidote protein HigA
BEST7613_7208	COG2807	transmembrane transport
BEST7613_7209	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BEST7613_7210	COG0359	binds to the 23S rRNA
BEST7613_7211	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BEST7613_7212	COG4241	membrane
BEST7613_7214	COG5577	PFAM Coat F domain
BEST7613_7215	COG1733	regulation of RNA biosynthetic process
BEST7613_7216	COG1227	inorganic diphosphatase activity
BEST7613_7219	COG2271	Major facilitator Superfamily
BEST7613_7226	COG1131	(ABC) transporter
BEST7613_7228	COG4319	ketosteroid isomerase
BEST7613_7229	COG1357	PFAM Pentapeptide repeats (8 copies)
BEST7613_7230	COG2814	Major facilitator Superfamily
BEST7613_7231	COG0583	DNA-binding transcription factor activity
BEST7613_7232	COG2153	protein acetylation
BEST7613_7234	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BEST7613_7235	COG1846	Transcriptional regulator
BEST7613_7236	COG2153	protein acetylation
BEST7613_7237	COG2364	Membrane
BEST7613_7238	COG0456	acetyltransferase
BEST7613_7239	COG2315	Protein conserved in bacteria
BEST7613_7240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BEST7613_7241	COG2814	Major facilitator Superfamily
BEST7613_7242	COG1331	Highly conserved protein containing a thioredoxin domain
BEST7613_7243	COG0789	Transcriptional regulator
BEST7613_7244	COG0697	spore germination
BEST7613_7245	COG1331	Highly conserved protein containing a thioredoxin domain
BEST7613_7246	COG1266	CAAX protease self-immunity
BEST7613_7247	COG2814	Major facilitator Superfamily
BEST7613_7247	COG0477	Major facilitator Superfamily
BEST7613_7248	COG0110	maltose O-acetyltransferase activity
BEST7613_7249	COG0346	lactoylglutathione lyase activity
BEST7613_7250	COG1609	Transcriptional regulator
BEST7613_7251	COG0708	Exodeoxyribonuclease III
BEST7613_7252	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BEST7613_7253	COG0629	single-stranded DNA binding
BEST7613_7254	COG0360	Binds together with S18 to 16S ribosomal RNA
BEST7613_7255	COG0012	GTP binding
BEST7613_7256	COG0243	molybdopterin cofactor binding
BEST7613_7257	COG4481	Protein conserved in bacteria
BEST7613_7258	COG3949	Membrane
BEST7613_7260	COG1475	DNA binding
BEST7613_7261	COG1192	Involved in chromosome partitioning
BEST7613_7263	COG1475	DNA binding
BEST7613_7264	COG0357	Ribosomal RNA small subunit methyltransferase G
BEST7613_7265	COG0445	tRNA wobble uridine modification
BEST7613_7266	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BEST7613_7267	COG1847	R3H domain protein
BEST7613_7268	COG0706	membrane insertase activity
BEST7613_7269	COG0594	ribonuclease P activity
BEST7613_7270	COG0230	Belongs to the bacterial ribosomal protein bL34 family