locus-tag	class	description
JR441_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JR441_00010	COG0592	DNA-directed DNA polymerase activity
JR441_00015	COG2501	S4 domain
JR441_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JR441_00030	COG0187	DNA topoisomerase II activity
JR441_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JR441_00070	COG0517	IMP dehydrogenase activity
JR441_00070	COG0516	GMP reductase activity
JR441_00075	COG1686	Belongs to the peptidase S11 family
JR441_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JR441_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JR441_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JR441_00100	COG1428	Deoxynucleoside kinase
JR441_00105	COG1428	Deoxynucleoside kinase
JR441_00110	COG3858	chitin binding
JR441_00110	COG1388	LysM domain
JR441_00115	COG1335	isochorismatase
JR441_00120	COG0590	tRNA wobble adenosine to inosine editing
JR441_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JR441_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JR441_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JR441_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
JR441_00190	COG3853	Toxic anion resistance protein (TelA)
JR441_00195	COG1982	Orn Lys Arg decarboxylase major
JR441_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JR441_00205	COG3870	Protein conserved in bacteria
JR441_00210	COG1728	Protein conserved in bacteria
JR441_00215	COG0470	DNA polymerase III
JR441_00220	COG1774	PSP1 C-terminal conserved region
JR441_00225	COG4467	Involved in initiation control of chromosome replication
JR441_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JR441_00235	COG2827	Endonuclease containing a URI domain
JR441_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JR441_00245	COG2002	toxin-antitoxin pair type II binding
JR441_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_00255	COG0084	hydrolase, TatD family'
JR441_00260	COG3583	domain protein
JR441_00260	COG3584	3D domain protein
JR441_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JR441_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JR441_00280	COG4466	Protein conserved in bacteria
JR441_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JR441_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JR441_00300	COG0251	oxidation-reduction process
JR441_00305	COG2088	sporulation resulting in formation of a cellular spore
JR441_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JR441_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JR441_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JR441_00325	COG0193	aminoacyl-tRNA hydrolase activity
JR441_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JR441_00340	COG2002	toxin-antitoxin pair type II binding
JR441_00345	COG2244	polysaccharide biosynthetic process
JR441_00350	COG3956	TIGRFAM MazG family protein
JR441_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JR441_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JR441_00375	COG1098	S1 RNA binding domain
JR441_00390	COG2208	phosphoserine phosphatase activity
JR441_00395	COG2304	oxidoreductase activity
JR441_00400	COG0515	serine threonine protein kinase
JR441_00405	COG0037	tRNA processing
JR441_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JR441_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JR441_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
JR441_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JR441_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JR441_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JR441_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JR441_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
JR441_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JR441_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JR441_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JR441_00470	COG1396	sequence-specific DNA binding
JR441_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JR441_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JR441_00560	COG4463	regulation of RNA biosynthetic process
JR441_00565	COG3880	PFAM UvrB UvrC protein
JR441_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JR441_00575	COG0542	response to heat
JR441_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JR441_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JR441_00590	COG4956	integral membrane protein (PIN domain superfamily)
JR441_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JR441_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JR441_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JR441_00610	COG1045	serine acetyltransferase
JR441_00615	COG0215	cysteine-tRNA ligase activity
JR441_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JR441_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JR441_00630	COG3688	RNA-binding protein containing a PIN domain
JR441_00635	COG1595	DNA-templated transcription, initiation
JR441_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JR441_00650	COG0250	Participates in transcription elongation, termination and antitermination
JR441_00660	COG0081	regulation of translation
JR441_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JR441_00675	COG2813	Specifically methylates the guanine in position
JR441_00680	COG0085	RNA polymerase activity
JR441_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JR441_00690	COG1358	cellular component organization or biogenesis
JR441_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JR441_00700	COG0049	tRNA binding
JR441_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JR441_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JR441_00715	COG0596	Alpha beta hydrolase
JR441_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JR441_00730	COG0088	Forms part of the polypeptide exit tunnel
JR441_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JR441_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JR441_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JR441_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JR441_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JR441_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JR441_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JR441_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JR441_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JR441_00820	COG0200	Binds to the 23S rRNA
JR441_00825	COG0201	protein transport
JR441_00830	COG0563	adenylate kinase activity
JR441_00835	COG0024	Methionine aminopeptidase
JR441_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JR441_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JR441_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JR441_00865	COG0202	RNA polymerase activity
JR441_00870	COG0203	ribosomal protein L17
JR441_00875	COG1122	ATPase activity
JR441_00880	COG1122	ATPase activity
JR441_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JR441_00890	COG0101	tRNA pseudouridine synthase activity
JR441_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JR441_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JR441_00905	COG2226	methyltransferase
JR441_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_00920	COG0489	protein tyrosine kinase activity
JR441_00930	COG2194	sulfuric ester hydrolase activity
JR441_00935	COG0726	polysaccharide deacetylase
JR441_01020	COG0659	secondary active sulfate transmembrane transporter activity
JR441_01025	COG0385	Bile acid
JR441_01030	COG2819	hydrolase of the alpha beta superfamily
JR441_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_01050	COG2207	Transcriptional regulator
JR441_01055	COG3876	Protein conserved in bacteria
JR441_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
JR441_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JR441_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_01070	COG1263	PTS System
JR441_01075	COG1737	Transcriptional regulator
JR441_01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JR441_01090	COG1683	Conserved Protein
JR441_01120	COG1595	DNA-templated transcription, initiation
JR441_01125	COG5662	AntiSigma factor
JR441_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JR441_01135	COG4856	YbbR-like protein
JR441_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JR441_01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JR441_01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JR441_01160	COG2169	Transcriptional regulator
JR441_01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JR441_01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JR441_01175	COG3002	Belongs to the UPF0753 family
JR441_01180	COG0288	reversible hydration of carbon dioxide
JR441_01190	COG5609	conserved protein (DUF2294)
JR441_01195	COG0640	Transcriptional regulator
JR441_01200	COG2814	Major facilitator Superfamily
JR441_01215	COG0596	Alpha beta hydrolase
JR441_01220	COG0745	RESPONSE REGULATOR receiver
JR441_01225	COG0642	Histidine kinase
JR441_01235	COG0515	serine threonine protein kinase
JR441_01250	COG1113	amino acid transport
JR441_01265	COG2602	Beta-lactamase
JR441_01270	COG2124	cytochrome p450
JR441_01280	COG0531	amino acid
JR441_01285	COG0584	glycerophosphoryl diester phosphodiesterase
JR441_01290	COG2271	Major facilitator Superfamily
JR441_01300	COG0456	acetyltransferase
JR441_01300	COG1846	Transcriptional regulator
JR441_01305	COG2271	Major facilitator Superfamily
JR441_01310	COG0697	spore germination
JR441_01315	COG1917	Cupin 2, conserved barrel domain protein
JR441_01315	COG2207	Transcriptional regulator
JR441_01320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JR441_01325	COG3591	Belongs to the peptidase S1B family
JR441_01335	COG0596	Alpha beta hydrolase
JR441_01340	COG1183	phosphatidylcholine synthase activity
JR441_01345	COG0586	Pfam SNARE associated Golgi protein
JR441_01350	COG0688	phosphatidylethanolamine metabolic process
JR441_01360	COG2312	Erythromycin esterase
JR441_01365	COG2207	Transcriptional regulator
JR441_01370	COG1054	Belongs to the UPF0176 family
JR441_01375	COG1301	dicarboxylic acid transport
JR441_01380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_01380	COG1263	PTS System
JR441_01380	COG2190	(PTS) system
JR441_01385	COG0363	glucosamine-6-phosphate deaminase activity
JR441_01390	COG2188	Transcriptional regulator
JR441_01400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_01405	COG0833	amino acid
JR441_01410	COG2040	homocysteine
JR441_01415	COG1115	amino acid carrier protein
JR441_01420	COG2066	Belongs to the glutaminase family
JR441_01425	COG4191	Histidine kinase
JR441_01430	COG0784	Response regulator, receiver
JR441_01435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JR441_01440	COG1012	belongs to the aldehyde dehydrogenase family
JR441_01445	COG2271	Major facilitator Superfamily
JR441_01450	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_01455	COG2186	Transcriptional regulator
JR441_01460	COG2721	sulfolactate sulfo-lyase activity
JR441_01465	COG3173	Aminoglycoside phosphotransferase
JR441_01475	COG0697	spore germination
JR441_01480	COG0745	RESPONSE REGULATOR receiver
JR441_01485	COG2205	protein histidine kinase activity
JR441_01490	COG1131	(ABC) transporter
JR441_01510	COG3773	Cell wall hydrolase
JR441_01515	COG2304	oxidoreductase activity
JR441_01525	COG3540	Alkaline phosphatase
JR441_01530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR441_01535	COG0805	protein transport
JR441_01540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JR441_01545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JR441_01550	COG0477	Major facilitator Superfamily
JR441_01555	COG1309	transcriptional regulator
JR441_01560	COG0252	asparaginase activity
JR441_01565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JR441_01570	COG1714	RDD family
JR441_01575	COG1405	negative regulation of cell septum assembly
JR441_01575	COG3012	SEC-C Motif Domain Protein
JR441_01580	COG3290	protein histidine kinase activity
JR441_01585	COG3279	Response regulator of the LytR AlgR family
JR441_01590	COG4555	ABC transporter
JR441_01595	COG1668	transmembrane transport
JR441_01600	COG0667	Aldo Keto reductase
JR441_01620	COG1595	DNA-templated transcription, initiation
JR441_01625	COG1876	peptidase activity
JR441_01630	COG0457	Tetratricopeptide repeat
JR441_01635	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_01640	COG0366	Alpha amylase catalytic
JR441_01645	COG0803	Belongs to the bacterial solute-binding protein 9 family
JR441_01650	COG1121	(ABC) transporter
JR441_01655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR441_01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_01665	COG2310	stress, protein
JR441_01670	COG2310	stress, protein
JR441_01675	COG2310	stress, protein
JR441_01680	COG0861	Integral membrane protein TerC family
JR441_01690	COG3853	Toxic anion resistance protein (TelA)
JR441_01695	COG0477	Major facilitator Superfamily
JR441_01700	COG2814	Major facilitator Superfamily
JR441_01705	COG0640	Transcriptional regulator
JR441_01710	COG4175	Glycine betaine
JR441_01710	COG0517	IMP dehydrogenase activity
JR441_01715	COG4176	ABC-type proline glycine betaine transport system permease component
JR441_01720	COG2113	Glycine betaine
JR441_01725	COG1473	amidohydrolase
JR441_01730	COG1288	antiporter activity
JR441_01740	COG0366	Alpha amylase catalytic
JR441_01745	COG0039	L-malate dehydrogenase activity
JR441_01750	COG1620	l-lactate permease
JR441_01755	COG2814	Major facilitator Superfamily
JR441_01760	COG1846	Transcriptional regulator
JR441_01765	COG1280	lysine exporter protein (LysE YggA)
JR441_01770	COG3403	YqcI/YcgG family
JR441_01775	COG1113	amino acid transport
JR441_01780	COG3665	Urea carboxylase-associated protein
JR441_01785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JR441_01790	COG1660	Displays ATPase and GTPase activities
JR441_01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JR441_01800	COG2226	methyltransferase
JR441_01805	COG0583	DNA-binding transcription factor activity
JR441_01810	COG3458	cephalosporin-C deacetylase activity
JR441_01815	COG3541	Predicted nucleotidyltransferase
JR441_01820	COG0506	proline dehydrogenase activity
JR441_01825	COG1012	belongs to the aldehyde dehydrogenase family
JR441_01830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_01835	COG2508	Transcriptional regulator
JR441_01840	COG3689	TIGRFAM TIGR03943 family protein
JR441_01845	COG0701	Predicted permease
JR441_01850	COG2267	carboxylic ester hydrolase activity
JR441_01855	COG0492	ferredoxin-NADP+ reductase activity
JR441_01860	COG1587	Uroporphyrinogen-III synthase
JR441_01860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JR441_01865	COG2146	nitrite reductase [NAD(P)H] activity
JR441_01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JR441_01875	COG0243	molybdopterin cofactor binding
JR441_01880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JR441_01885	COG2223	nitrite transmembrane transporter activity
JR441_01890	COG1469	GTP cyclohydrolase I activity
JR441_01905	COG0523	cobalamin synthesis protein
JR441_01910	COG0765	amino acid transport
JR441_01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_01925	COG1714	RDD family
JR441_01935	COG2723	6-phospho-beta-galactosidase activity
JR441_01945	COG3209	COG3209 Rhs family protein
JR441_01950	COG3290	protein histidine kinase activity
JR441_01950	COG0840	transmembrane signaling receptor activity
JR441_01955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JR441_01960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JR441_01965	COG1733	regulation of RNA biosynthetic process
JR441_01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
JR441_02000	COG0697	spore germination
JR441_02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_02015	COG2364	Membrane
JR441_02020	COG1126	abc transporter atp-binding protein
JR441_02025	COG0765	amino acid transport
JR441_02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_02035	COG0583	DNA-binding transcription factor activity
JR441_02040	COG0163	prenyltransferase activity
JR441_02045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JR441_02060	COG0596	Alpha beta hydrolase
JR441_02065	COG3104	oligopeptide transport
JR441_02070	COG5434	Belongs to the glycosyl hydrolase 28 family
JR441_02080	COG0697	spore germination
JR441_02090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JR441_02095	COG1136	(ABC) transporter
JR441_02100	COG0577	efflux transmembrane transporter activity
JR441_02105	COG0745	RESPONSE REGULATOR receiver
JR441_02110	COG5002	protein histidine kinase activity
JR441_02110	COG3850	Histidine kinase
JR441_02115	COG0457	Tetratricopeptide repeat
JR441_02135	COG0527	aspartate kinase activity
JR441_02140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_02145	COG4605	iron ion homeostasis
JR441_02150	COG4604	ABC transporter, ATP-binding protein
JR441_02155	COG4607	ABC-type enterochelin transport system periplasmic component
JR441_02160	COG2814	Major facilitator Superfamily
JR441_02165	COG1309	transcriptional regulator
JR441_02170	COG0778	Nitroreductase
JR441_02175	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JR441_02180	COG0640	Transcriptional regulator
JR441_02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JR441_02195	COG1012	belongs to the aldehyde dehydrogenase family
JR441_02220	COG4975	Glucose uptake
JR441_02225	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_02230	COG4549	nuclear export factor GLE1
JR441_02235	COG2372	response to copper ion
JR441_02235	COG1276	copper resistance
JR441_02240	COG1349	DNA-binding transcription factor activity
JR441_02250	COG2213	PTS system mannitol-specific
JR441_02255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_02260	COG0246	Mannitol dehydrogenase
JR441_02265	COG0473	3-isopropylmalate dehydrogenase activity
JR441_02270	COG0681	Belongs to the peptidase S26 family
JR441_02275	COG0412	Dienelactone hydrolase
JR441_02280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JR441_02290	COG0561	phosphatase activity
JR441_02295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JR441_02300	COG1914	H( )-stimulated, divalent metal cation uptake system
JR441_02305	COG4336	lyase activity
JR441_02310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JR441_02315	COG1984	allophanate hydrolase subunit 2
JR441_02320	COG1414	Transcriptional regulator
JR441_02325	COG2755	lipolytic protein G-D-S-L family
JR441_02335	COG2329	Antibiotic biosynthesis monooxygenase
JR441_02340	COG0768	penicillin binding
JR441_02345	COG4989	oxidoreductase activity
JR441_02350	COG3711	transcriptional antiterminator
JR441_02355	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_02360	COG2226	methyltransferase
JR441_02365	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_02370	COG1917	Cupin 2, conserved barrel domain protein
JR441_02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_02380	COG3871	stress protein (general stress protein 26)
JR441_02390	COG2814	Major facilitator Superfamily
JR441_02395	COG1522	sequence-specific DNA binding
JR441_02400	COG0551	DNA topoisomerase type I activity
JR441_02400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JR441_02405	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
JR441_02410	COG3706	GGDEF domain
JR441_02415	COG5298	Protein conserved in bacteria
JR441_02420	COG1215	transferase activity, transferring glycosyl groups
JR441_02430	COG0531	amino acid
JR441_02435	COG0494	nUDIX hydrolase
JR441_02440	COG0028	Belongs to the TPP enzyme family
JR441_02455	COG1914	H( )-stimulated, divalent metal cation uptake system
JR441_02460	COG2261	transglycosylase associated protein
JR441_02465	COG4876	unkown
JR441_02470	COG2217	Heavy metal translocating P-type atpase
JR441_02475	COG3729	General stress protein
JR441_02480	COG0662	Cupin 2, conserved barrel domain protein
JR441_02485	COG2329	Antibiotic biosynthesis monooxygenase
JR441_02490	COG3546	catalase activity
JR441_02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JR441_02500	COG3290	protein histidine kinase activity
JR441_02505	COG4565	transcriptional regulatory protein
JR441_02510	COG1301	dicarboxylic acid transport
JR441_02515	COG0628	permease
JR441_02520	COG1131	(ABC) transporter
JR441_02525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JR441_02535	COG1960	acyl-CoA dehydrogenase activity
JR441_02550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JR441_02555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_02560	COG1181	Belongs to the D-alanine--D-alanine ligase family
JR441_02565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JR441_02570	COG0513	Belongs to the DEAD box helicase family
JR441_02575	COG3402	PFAM membrane-flanked domain
JR441_02580	COG3428	Bacterial PH domain
JR441_02585	COG0705	Rhomboid family
JR441_02590	COG0736	holo-[acyl-carrier-protein] synthase activity
JR441_02595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JR441_02600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JR441_02605	COG0864	Transcriptional regulator
JR441_02610	COG2337	Toxic component of a toxin-antitoxin (TA) module
JR441_02615	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_02620	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_02625	COG2172	sigma factor antagonist activity
JR441_02630	COG2208	phosphoserine phosphatase activity
JR441_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_02640	COG2172	sigma factor antagonist activity
JR441_02645	COG1191	sigma factor activity
JR441_02650	COG2208	phosphoserine phosphatase activity
JR441_02655	COG2183	response to ionizing radiation
JR441_02665	COG3091	SprT-like family
JR441_02705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_02715	COG5444	nuclease activity
JR441_02720	COG1476	TRANSCRIPTIONal
JR441_02730	COG3239	Fatty acid desaturase
JR441_02735	COG1278	Cold shock
JR441_02740	COG1329	Transcriptional regulator
JR441_02745	COG0697	spore germination
JR441_02750	COG2207	Transcriptional regulator
JR441_02750	COG1917	Cupin 2, conserved barrel domain protein
JR441_02755	COG0697	spore germination
JR441_02760	COG3708	Transcriptional regulator
JR441_02760	COG2207	Transcriptional regulator
JR441_02765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_02770	COG0477	Major facilitator Superfamily
JR441_02780	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
JR441_02800	COG1309	transcriptional regulator
JR441_02805	COG0697	spore germination
JR441_02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_02815	COG2030	dehydratase
JR441_02820	COG3545	Serine hydrolase
JR441_02825	COG1733	regulation of RNA biosynthetic process
JR441_02830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_02835	COG2814	Major facilitator Superfamily
JR441_02840	COG1309	transcriptional regulator
JR441_02845	COG0640	Transcriptional regulator
JR441_02850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JR441_02860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_02865	COG0697	spore germination
JR441_02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_02875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JR441_02880	COG0640	Transcriptional regulator
JR441_02885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JR441_02900	COG4585	Histidine kinase
JR441_02905	COG2197	response regulator
JR441_02910	COG2409	Drug exporters of the RND superfamily
JR441_02915	COG0596	Alpha beta hydrolase
JR441_02920	COG1811	Na channel or pump
JR441_02925	COG4978	Transcriptional regulator
JR441_02925	COG0789	Transcriptional regulator
JR441_02930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JR441_02935	COG0778	Nitroreductase
JR441_02940	COG0346	lactoylglutathione lyase activity
JR441_02945	COG2259	Doxx family
JR441_02950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_02965	COG2323	membrane
JR441_02970	COG2323	membrane
JR441_02975	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_02990	COG1309	transcriptional regulator
JR441_03000	COG0456	acetyltransferase
JR441_03005	COG0488	(ABC) transporter
JR441_03010	COG1113	amino acid transport
JR441_03015	COG2318	DinB family
JR441_03020	COG1846	Transcriptional regulator
JR441_03025	COG1033	growth of symbiont in host cell
JR441_03025	COG2409	Drug exporters of the RND superfamily
JR441_03030	COG0778	Nitroreductase
JR441_03035	COG1846	Transcriptional regulator
JR441_03040	COG2814	Major facilitator Superfamily
JR441_03045	COG0730	response to heat
JR441_03050	COG1802	Transcriptional regulator
JR441_03055	COG1388	LysM domain
JR441_03055	COG3858	chitin binding
JR441_03060	COG1819	glycosyl
JR441_03070	COG1785	Belongs to the alkaline phosphatase family
JR441_03075	COG5646	InterPro IPR014922
JR441_03085	COG0454	-acetyltransferase
JR441_03090	COG1078	dGTPase activity
JR441_03095	COG1388	LysM domain
JR441_03100	COG2814	Major facilitator Superfamily
JR441_03105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_03110	COG1447	Phosphotransferase system cellobiose-specific component IIA
JR441_03115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_03120	COG2723	6-phospho-beta-galactosidase activity
JR441_03125	COG2188	Transcriptional regulator
JR441_03130	COG1940	carbohydrate kinase activity
JR441_03135	COG1482	cell wall glycoprotein biosynthetic process
JR441_03140	COG4124	Belongs to the glycosyl hydrolase 26 family
JR441_03185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JR441_03190	COG0802	atpase or kinase
JR441_03195	COG1214	PFAM Peptidase M22, glycoprotease
JR441_03200	COG0456	acetyltransferase
JR441_03205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JR441_03210	COG0488	(ABC) transporter
JR441_03215	COG0315	cyclic pyranopterin monophosphate synthase activity
JR441_03220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JR441_03225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR441_03230	COG0805	protein transport
JR441_03240	COG1266	CAAX protease self-immunity
JR441_03250	COG0459	protein refolding
JR441_03255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JR441_03270	COG0457	Tetratricopeptide repeat
JR441_03275	COG1063	alcohol dehydrogenase
JR441_03280	COG2211	Major facilitator Superfamily
JR441_03285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_03290	COG1842	Phage shock protein A
JR441_03295	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JR441_03300	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JR441_03305	COG4260	virion core protein, lumpy skin disease virus
JR441_03315	COG2814	Major facilitator Superfamily
JR441_03320	COG1063	alcohol dehydrogenase
JR441_03325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JR441_03330	COG0823	Involved in the tonB-independent uptake of proteins
JR441_03345	COG2267	carboxylic ester hydrolase activity
JR441_03355	COG2132	Multicopper oxidase
JR441_03360	COG1113	amino acid transport
JR441_03370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JR441_03375	COG0714	Associated with various cellular activities
JR441_03380	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
JR441_03385	COG1305	Transglutaminase-like
JR441_03390	COG0519	Catalyzes the synthesis of GMP from XMP
JR441_03390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JR441_03405	COG2252	PERMEase
JR441_03410	COG3064	Membrane
JR441_03420	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JR441_03430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JR441_03435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JR441_03440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JR441_03445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JR441_03450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JR441_03455	COG0047	phosphoribosylformylglycinamidine synthase activity
JR441_03460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JR441_03465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JR441_03470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JR441_03475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JR441_03480	COG0138	bifunctional purine biosynthesis protein purh
JR441_03485	COG0151	Belongs to the GarS family
JR441_03490	COG1522	sequence-specific DNA binding
JR441_03495	COG0531	amino acid
JR441_03505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JR441_03510	COG1470	cell adhesion involved in biofilm formation
JR441_03515	COG4496	protein, YerC YecD
JR441_03520	COG0069	glutamate synthase activity
JR441_03525	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JR441_03530	COG0210	DNA helicase
JR441_03535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JR441_03540	COG4851	CamS sex pheromone cAM373 precursor
JR441_03545	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_03550	COG1285	pathogenesis
JR441_03555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_03560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JR441_03565	COG0154	amidase activity
JR441_03570	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JR441_03575	COG1309	transcriptional regulator
JR441_03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JR441_03585	COG1597	lipid kinase activity
JR441_03590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JR441_03620	COG3391	amine dehydrogenase activity
JR441_03630	COG0457	Tetratricopeptide repeat
JR441_03640	COG0217	transcriptional regulatory protein
JR441_03660	COG3546	catalase activity
JR441_03665	COG0454	-acetyltransferase
JR441_03675	COG5578	integral membrane protein
JR441_03680	COG2972	Histidine kinase
JR441_03685	COG4753	response regulator
JR441_03685	COG2207	Transcriptional regulator
JR441_03690	COG1653	transport
JR441_03695	COG1175	transmembrane transport
JR441_03700	COG0395	ABC-type sugar transport system, permease component
JR441_03705	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JR441_03710	COG2207	Transcriptional regulator
JR441_03715	COG2755	lipolytic protein G-D-S-L family
JR441_03725	COG5578	integral membrane protein
JR441_03730	COG3401	FG-GAP repeat protein
JR441_03735	COG3401	FG-GAP repeat protein
JR441_03740	COG2755	lipolytic protein G-D-S-L family
JR441_03745	COG1874	Beta-galactosidase
JR441_03755	COG1653	transport
JR441_03760	COG4209	transmembrane transport
JR441_03765	COG0395	ABC-type sugar transport system, permease component
JR441_03770	COG1486	melibiose metabolic process
JR441_03775	COG2323	membrane
JR441_03780	COG2329	Antibiotic biosynthesis monooxygenase
JR441_03785	COG0346	lactoylglutathione lyase activity
JR441_03800	COG5583	Uncharacterized small protein (DUF2292)
JR441_03805	COG0670	Belongs to the BI1 family
JR441_03825	COG2124	cytochrome p450
JR441_03825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JR441_03830	COG1368	sulfuric ester hydrolase activity
JR441_03835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JR441_03840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_03845	COG1442	glycosyl transferase family 8
JR441_03850	COG1216	Glycosyl transferase, family 2
JR441_03855	COG1442	glycosyl transferase family 8
JR441_03860	COG2223	nitrite transmembrane transporter activity
JR441_03865	COG1011	Hydrolase
JR441_03870	COG0531	amino acid
JR441_03875	COG1012	belongs to the aldehyde dehydrogenase family
JR441_03880	COG0840	transmembrane signaling receptor activity
JR441_03885	COG0488	(ABC) transporter
JR441_03895	COG0789	Transcriptional regulator
JR441_03900	COG2814	Major facilitator Superfamily
JR441_03910	COG0488	(ABC) transporter
JR441_03915	COG0513	Belongs to the DEAD box helicase family
JR441_03920	COG0456	acetyltransferase
JR441_03925	COG2130	NADP-dependent
JR441_03930	COG1120	ATPase activity
JR441_03935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_03945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JR441_03960	COG3866	Pectate lyase
JR441_03965	COG0471	metal ion transport
JR441_03970	COG3290	protein histidine kinase activity
JR441_03975	COG4565	transcriptional regulatory protein
JR441_03980	COG3181	Tripartite tricarboxylate transporter family receptor
JR441_03985	COG2851	Citrate transporter
JR441_03990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_03995	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
JR441_04000	COG1254	Belongs to the acylphosphatase family
JR441_04005	COG2258	MOSC domain
JR441_04025	COG0024	Methionine aminopeptidase
JR441_04030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_04030	COG1263	PTS System
JR441_04035	COG1368	sulfuric ester hydrolase activity
JR441_04050	COG1115	amino acid carrier protein
JR441_04055	COG0531	amino acid
JR441_04070	COG0697	spore germination
JR441_04075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_04075	COG1263	PTS System
JR441_04080	COG0366	Alpha amylase catalytic
JR441_04085	COG2188	Transcriptional regulator
JR441_04090	COG0778	Nitroreductase
JR441_04095	COG0737	Belongs to the 5'-nucleotidase family
JR441_04100	COG0693	protein deglycase activity
JR441_04105	COG2814	Major facilitator Superfamily
JR441_04110	COG4840	Belongs to the UPF0435 family
JR441_04115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR441_04120	COG4980	gas vesicle protein
JR441_04125	COG1295	ribonuclease BN
JR441_04130	COG0477	Major facilitator Superfamily
JR441_04135	COG0387	Pfam Sodium calcium exchanger
JR441_04145	COG0668	transmembrane transport
JR441_04150	COG0535	radical SAM domain protein
JR441_04160	COG0726	polysaccharide deacetylase
JR441_04165	COG2084	Dehydrogenase
JR441_04170	COG0598	Magnesium transport protein CorA
JR441_04175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JR441_04180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JR441_04190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JR441_04195	COG4637	Psort location Cytoplasmic, score
JR441_04200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JR441_04205	COG0022	dehydrogenase e1 component
JR441_04210	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_04215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JR441_04220	COG3284	Transcriptional regulator
JR441_04230	COG1742	UPF0060 membrane protein
JR441_04255	COG4842	Belongs to the WXG100 family
JR441_04260	COG1486	melibiose metabolic process
JR441_04265	COG1737	Transcriptional regulator
JR441_04270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_04270	COG1263	PTS System
JR441_04275	COG5434	Belongs to the glycosyl hydrolase 28 family
JR441_04280	COG1132	(ABC) transporter
JR441_04285	COG1132	(ABC) transporter
JR441_04290	COG2259	Doxx family
JR441_04295	COG2514	catechol 2,3-dioxygenase activity
JR441_04300	COG4585	Histidine kinase
JR441_04305	COG2197	response regulator
JR441_04310	COG1131	(ABC) transporter
JR441_04315	COG1511	domain protein
JR441_04315	COG0842	Transport permease protein
JR441_04320	COG0842	Transport permease protein
JR441_04325	COG1695	Transcriptional regulator
JR441_04335	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
JR441_04340	COG1309	transcriptional regulator
JR441_04345	COG2814	Major facilitator Superfamily
JR441_04350	COG2318	DinB family
JR441_04355	COG2814	Major facilitator Superfamily
JR441_04360	COG1846	Transcriptional regulator
JR441_04365	COG0392	lysyltransferase activity
JR441_04365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JR441_04370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_04375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_04380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_04385	COG0384	phenazine biosynthesis protein PhzF
JR441_04390	COG0778	Nitroreductase
JR441_04405	COG1090	epimerase
JR441_04410	COG2137	regulation of response to DNA damage stimulus
JR441_04420	COG2814	Major facilitator Superfamily
JR441_04435	COG3103	Sh3 type 3 domain protein
JR441_04440	COG5658	integral membrane protein
JR441_04445	COG0596	Alpha beta hydrolase
JR441_04450	COG0463	Glycosyl transferase, family 2
JR441_04455	COG4485	Bacterial membrane protein, YfhO
JR441_04460	COG1988	membrane-bound metal-dependent
JR441_04465	COG1194	a g-specific adenine glycosylase
JR441_04475	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_04490	COG3557	Belongs to the UPF0374 family
JR441_04495	COG1132	(ABC) transporter
JR441_04500	COG4129	membrane
JR441_04505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JR441_04510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JR441_04515	COG0735	belongs to the Fur family
JR441_04625	COG4326	sporulation control protein
JR441_04635	COG5577	PFAM Coat F domain
JR441_04645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JR441_04650	COG0277	FAD linked oxidase domain protein
JR441_04660	COG0753	catalase activity
JR441_04665	COG1116	anion transmembrane transporter activity
JR441_04670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JR441_04675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JR441_04680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_04690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JR441_04700	COG1476	TRANSCRIPTIONal
JR441_04710	COG3382	B3 4 domain protein
JR441_04715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JR441_04725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JR441_04730	COG0789	Transcriptional regulator
JR441_04740	COG1664	Polymer-forming cytoskeletal
JR441_04745	COG2766	serine protein kinase
JR441_04750	COG2718	Belongs to the UPF0229 family
JR441_04755	COG1846	Transcriptional regulator
JR441_04760	COG1566	PFAM secretion protein HlyD family protein
JR441_04765	COG2814	Major facilitator Superfamily
JR441_04770	COG0655	NAD(P)H dehydrogenase (quinone) activity
JR441_04790	COG1725	Transcriptional regulator
JR441_04795	COG1131	(ABC) transporter
JR441_04800	COG1131	(ABC) transporter
JR441_04805	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JR441_04810	COG1278	Cold shock
JR441_04815	COG1464	Belongs to the NlpA lipoprotein family
JR441_04820	COG3706	GGDEF domain
JR441_04825	COG1823	symporter activity
JR441_04845	COG5577	PFAM Coat F domain
JR441_04850	COG0737	Belongs to the 5'-nucleotidase family
JR441_04850	COG1525	nuclease
JR441_04850	COG4085	toxin activity
JR441_04855	COG3764	Sortase (surface protein transpeptidase)
JR441_04860	COG0564	pseudouridine synthase activity
JR441_04870	COG0517	IMP dehydrogenase activity
JR441_04875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JR441_04880	COG3153	acetyltransferase
JR441_04880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JR441_04885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JR441_04890	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JR441_04895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JR441_04900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JR441_04905	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JR441_04910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JR441_04915	COG4585	Histidine kinase
JR441_04915	COG2203	Gaf domain
JR441_04920	COG2197	response regulator
JR441_04925	COG0431	NADPH-dependent FMN reductase
JR441_04940	COG1388	LysM domain
JR441_04940	COG0791	NLP P60 protein
JR441_04945	COG1959	2 iron, 2 sulfur cluster binding
JR441_04950	COG0668	transmembrane transport
JR441_04955	COG2719	SpoVR family
JR441_04960	COG1785	Belongs to the alkaline phosphatase family
JR441_04965	COG0791	NLP P60 protein
JR441_04965	COG1388	LysM domain
JR441_04970	COG0583	DNA-binding transcription factor activity
JR441_04975	COG0372	Belongs to the citrate synthase family
JR441_04980	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_04985	COG0531	amino acid
JR441_04990	COG0733	neurotransmitter:sodium symporter activity
JR441_05000	COG0456	acetyltransferase
JR441_05015	COG1595	DNA-templated transcription, initiation
JR441_05020	COG0667	Aldo Keto reductase
JR441_05025	COG0204	Acyl-transferase
JR441_05030	COG1253	flavin adenine dinucleotide binding
JR441_05035	COG0789	Transcriptional regulator
JR441_05040	COG0436	Aminotransferase
JR441_05045	COG1253	flavin adenine dinucleotide binding
JR441_05050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JR441_05055	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JR441_05060	COG0584	glycerophosphoryl diester phosphodiesterase
JR441_05070	COG0668	transmembrane transport
JR441_05075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JR441_05080	COG0726	polysaccharide deacetylase
JR441_05085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_05090	COG1757	Na H antiporter
JR441_05095	COG0589	response to stress
JR441_05105	COG1132	(ABC) transporter
JR441_05110	COG1132	(ABC) transporter
JR441_05115	COG0702	epimerase
JR441_05135	COG0189	ligase activity
JR441_05140	COG0189	ligase activity
JR441_05145	COG4399	Belongs to the UPF0754 family
JR441_05150	COG3679	Belongs to the UPF0342 family
JR441_05155	COG4335	DNA alkylation repair
JR441_05160	COG0561	phosphatase activity
JR441_05165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JR441_05170	COG0475	glutathione-regulated potassium exporter activity
JR441_05175	COG0490	domain, Protein
JR441_05185	COG1024	Enoyl-CoA hydratase
JR441_05195	COG4152	abc transporter atp-binding protein
JR441_05200	COG1668	transmembrane transport
JR441_05205	COG0420	3'-5' exonuclease activity
JR441_05210	COG4717	serine-type aminopeptidase activity
JR441_05215	COG3481	metal-dependent phosphohydrolase, HD sub domain
JR441_05225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JR441_05255	COG1846	Transcriptional regulator
JR441_05260	COG4980	gas vesicle protein
JR441_05275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JR441_05280	COG0537	adenosine 5'-monophosphoramidase activity
JR441_05285	COG1131	(ABC) transporter
JR441_05290	COG4473	ABC transporter
JR441_05300	COG1473	amidohydrolase
JR441_05305	COG3069	C4-dicarboxylate transmembrane transporter activity
JR441_05315	COG2329	Antibiotic biosynthesis monooxygenase
JR441_05320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_05325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JR441_05330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JR441_05335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JR441_05340	COG1309	transcriptional regulator
JR441_05345	COG1511	domain protein
JR441_05350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR441_05355	COG4377	Putative membrane peptidase family (DUF2324)
JR441_05365	COG1363	Peptidase, m42
JR441_05370	COG4405	Protein conserved in bacteria
JR441_05375	COG1301	dicarboxylic acid transport
JR441_05385	COG1234	tRNA 3'-trailer cleavage
JR441_05390	COG0095	Lipoate-protein ligase
JR441_05395	COG0702	epimerase
JR441_05400	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_05410	COG0501	Belongs to the peptidase M48B family
JR441_05420	COG0456	acetyltransferase
JR441_05425	COG0604	alcohol dehydrogenase
JR441_05430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JR441_05435	COG0406	alpha-ribazole phosphatase activity
JR441_05440	COG0183	Belongs to the thiolase family
JR441_05445	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_05450	COG1268	BioY protein
JR441_05455	COG0840	transmembrane signaling receptor activity
JR441_05460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JR441_05460	COG0723	plastoquinol--plastocyanin reductase activity
JR441_05465	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_05475	COG4903	ComK protein
JR441_05480	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_05490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_05505	COG0398	Pfam SNARE associated Golgi protein
JR441_05510	COG0681	Belongs to the peptidase S26 family
JR441_05515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JR441_05520	COG1846	Transcriptional regulator
JR441_05525	COG0738	Major facilitator superfamily
JR441_05530	COG0673	inositol 2-dehydrogenase activity
JR441_05535	COG0561	phosphatase activity
JR441_05540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_05545	COG1609	Transcriptional regulator
JR441_05550	COG3180	Ammonia monooxygenase
JR441_05555	COG2814	Major facilitator Superfamily
JR441_05555	COG0477	Major facilitator Superfamily
JR441_05560	COG4533	DNA binding
JR441_05570	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
JR441_05575	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JR441_05580	COG1074	ATP-dependent DNA helicase activity
JR441_05585	COG0420	3'-5' exonuclease activity
JR441_05590	COG0419	ATPase involved in DNA repair
JR441_05595	COG1403	HNH endonuclease
JR441_05635	COG5337	Spore coat protein CotH
JR441_05640	COG0179	Fumarylacetoacetate (FAA) hydrolase
JR441_05650	COG1404	Belongs to the peptidase S8 family
JR441_05660	COG0367	asparagine synthase
JR441_05665	COG2318	DinB family
JR441_05670	COG1562	ergosterol biosynthetic process
JR441_05675	COG0534	Mate efflux family protein
JR441_05680	COG2207	Transcriptional regulator
JR441_05680	COG1917	Cupin 2, conserved barrel domain protein
JR441_05685	COG1609	Transcriptional regulator
JR441_05690	COG0673	inositol 2-dehydrogenase activity
JR441_05695	COG2318	DinB family
JR441_05700	COG1279	arginine transmembrane transporter activity
JR441_05705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JR441_05710	COG1357	PFAM Pentapeptide repeats (8 copies)
JR441_05715	COG2267	carboxylic ester hydrolase activity
JR441_05720	COG0529	Catalyzes the synthesis of activated sulfate
JR441_05725	COG2046	Belongs to the sulfate adenylyltransferase family
JR441_05730	COG0175	sulfate reduction
JR441_05735	COG2045	Belongs to the ComB family
JR441_05740	COG1809	phosphosulfolactate synthase activity
JR441_05745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_05750	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_05755	COG2814	Major facilitator Superfamily
JR441_05760	COG0454	-acetyltransferase
JR441_05765	COG2153	protein acetylation
JR441_05770	COG0646	methionine synthase
JR441_05770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JR441_05775	COG1666	GTP binding
JR441_05780	COG2996	Protein conserved in bacteria
JR441_05800	COG1695	Transcriptional regulator
JR441_05815	COG3227	Zinc metalloprotease (Elastase)
JR441_05820	COG1307	EDD domain protein, DegV family
JR441_05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_05845	COG0561	phosphatase activity
JR441_05850	COG1073	alpha beta
JR441_05855	COG2151	metal-sulfur cluster biosynthetic enzyme
JR441_05865	COG0277	FAD linked oxidase domain protein
JR441_05870	COG2271	Major facilitator Superfamily
JR441_05875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JR441_05880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JR441_05890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JR441_05895	COG0505	Belongs to the CarA family
JR441_05900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JR441_05905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JR441_05920	COG2267	carboxylic ester hydrolase activity
JR441_05930	COG1744	ABC transporter substrate-binding protein PnrA-like
JR441_05945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR441_05950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JR441_05955	COG5504	Zn-dependent protease
JR441_05960	COG0444	Belongs to the ABC transporter superfamily
JR441_05965	COG4608	Belongs to the ABC transporter superfamily
JR441_05975	COG0601	transmembrane transport
JR441_05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JR441_05990	COG0180	Tryptophanyl-tRNA synthetase
JR441_05995	COG4166	transmembrane transport
JR441_06000	COG0601	transmembrane transport
JR441_06005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JR441_06010	COG0444	Belongs to the ABC transporter superfamily
JR441_06015	COG4608	Belongs to the ABC transporter superfamily
JR441_06020	COG2814	Major facilitator Superfamily
JR441_06025	COG0456	acetyltransferase
JR441_06030	COG1393	Belongs to the ArsC family
JR441_06035	COG0861	Integral membrane protein TerC family
JR441_06045	COG4862	establishment of competence for transformation
JR441_06055	COG4469	Competence protein
JR441_06060	COG1164	Oligoendopeptidase f
JR441_06070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JR441_06075	COG2346	COG2346, Truncated hemoglobins
JR441_06080	COG0741	lytic transglycosylase activity
JR441_06085	COG4116	CYTH
JR441_06095	COG2357	RelA SpoT domain protein
JR441_06100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JR441_06105	COG0564	pseudouridine synthase activity
JR441_06110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JR441_06115	COG0569	domain protein
JR441_06115	COG0475	glutathione-regulated potassium exporter activity
JR441_06120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JR441_06125	COG0352	thiamine-phosphate diphosphorylase activity
JR441_06130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JR441_06135	COG2104	thiamine diphosphate biosynthetic process
JR441_06140	COG2022	thiamine diphosphate biosynthetic process
JR441_06145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JR441_06150	COG0351	phosphomethylpyrimidine kinase
JR441_06155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JR441_06210	COG0210	DNA helicase
JR441_06220	COG2153	protein acetylation
JR441_06225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JR441_06230	COG2382	esterase
JR441_06235	COG0626	cystathionine gamma-synthase activity
JR441_06240	COG0626	cystathionine gamma-synthase activity
JR441_06245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_06250	COG5505	Protein of unknown function (DUF819)
JR441_06260	COG4974	Belongs to the 'phage' integrase family
JR441_06265	COG2856	Zn peptidase
JR441_06275	COG1396	sequence-specific DNA binding
JR441_06320	COG5377	YqaJ viral recombinase family
JR441_06325	COG3723	Recombinational DNA repair protein, rece pathway
JR441_06330	COG3935	DnaD domain protein
JR441_06335	COG1484	DNA-dependent DNA replication
JR441_06395	COG3677	Transposase
JR441_06410	COG5484	DNA packaging
JR441_06530	COG4824	toxin secretion phage lysis holin
JR441_06535	COG3409	Peptidoglycan-binding domain 1 protein
JR441_06535	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_06545	COG5444	nuclease activity
JR441_06550	COG0758	DNA mediated transformation
JR441_06555	COG1040	competence protein
JR441_06570	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JR441_06575	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_06585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_06585	COG3711	transcriptional antiterminator
JR441_06590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_06590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_06590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_06595	COG1482	cell wall glycoprotein biosynthetic process
JR441_06605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_06615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JR441_06630	COG0109	protoheme IX farnesyltransferase activity
JR441_06640	COG0726	polysaccharide deacetylase
JR441_06655	COG5504	Zn-dependent protease
JR441_06660	COG2205	protein histidine kinase activity
JR441_06670	COG3383	formate dehydrogenase (NAD+) activity
JR441_06675	COG2427	Protein of unknown function (DUF1641)
JR441_06685	COG1051	belongs to the nudix hydrolase family
JR441_06695	COG2124	cytochrome p450
JR441_06700	COG1819	glycosyl
JR441_06710	COG1587	Uroporphyrinogen-III synthase
JR441_06715	COG0390	transport system, permease component
JR441_06720	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JR441_06725	COG0697	spore germination
JR441_06730	COG4297	protein containing double-stranded beta helix domain
JR441_06740	COG1252	NADH dehydrogenase
JR441_06745	COG1904	glucuronate isomerase
JR441_06750	COG2211	Major facilitator Superfamily
JR441_06755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JR441_06760	COG1063	alcohol dehydrogenase
JR441_06765	COG1312	Catalyzes the dehydration of D-mannonate
JR441_06770	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_06775	COG2271	Major facilitator Superfamily
JR441_06780	COG1609	Transcriptional regulator
JR441_06785	COG0246	Mannitol dehydrogenase
JR441_06790	COG2721	sulfolactate sulfo-lyase activity
JR441_06795	COG0730	response to heat
JR441_06800	COG2318	DinB family
JR441_06805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JR441_06810	COG0457	Tetratricopeptide repeat
JR441_06820	COG2350	Protein conserved in bacteria
JR441_06825	COG1388	LysM domain
JR441_06825	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_06825	COG3409	Peptidoglycan-binding domain 1 protein
JR441_06835	COG4195	phage-related replication protein
JR441_06840	COG3546	catalase activity
JR441_06845	COG2856	Zn peptidase
JR441_06850	COG1396	sequence-specific DNA binding
JR441_06860	COG1522	sequence-specific DNA binding
JR441_06865	COG1484	DNA-dependent DNA replication
JR441_06885	COG1595	DNA-templated transcription, initiation
JR441_06890	COG3728	DNA packaging
JR441_06890	COG5484	DNA packaging
JR441_06895	COG1783	phage Terminase large subunit
JR441_06900	COG5518	Phage portal protein
JR441_06905	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JR441_06910	COG4653	Phage capsid family
JR441_06960	COG5412	phage tail tape measure protein
JR441_06960	COG5412	phage tail tape measure protein
JR441_06960	COG3953	SLT domain
JR441_06960	COG3953	SLT domain
JR441_06965	COG1652	LysM domain
JR441_06970	COG4193	domain, Protein
JR441_06980	COG3628	GPW Gp25 family protein
JR441_06985	COG3299	homolog of phage Mu protein gp47
JR441_06990	COG3778	Protein conserved in bacteria
JR441_07030	COG3409	Peptidoglycan-binding domain 1 protein
JR441_07030	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_07035	COG3594	Acyltransferase
JR441_07055	COG0306	phosphate transporter
JR441_07060	COG1392	Phosphate transport regulator
JR441_07065	COG0531	amino acid
JR441_07070	COG0346	lactoylglutathione lyase activity
JR441_07075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JR441_07080	COG0463	Glycosyl transferase, family 2
JR441_07090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_07095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_07100	COG2362	D-Aminopeptidase
JR441_07105	COG0601	transmembrane transport
JR441_07110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JR441_07115	COG0444	Belongs to the ABC transporter superfamily
JR441_07120	COG4166	transmembrane transport
JR441_07125	COG1619	proteins homologs of microcin C7 resistance protein MccF
JR441_07130	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_07135	COG0791	NLP P60 protein
JR441_07140	COG4608	Belongs to the ABC transporter superfamily
JR441_07145	COG2706	6-phosphogluconolactonase activity
JR441_07150	COG1834	amidinotransferase
JR441_07155	COG1607	acyl-coa hydrolase
JR441_07160	COG1017	nitric oxide dioxygenase activity
JR441_07160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JR441_07170	COG2323	membrane
JR441_07175	COG2318	DinB family
JR441_07180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_07185	COG2076	Multidrug Resistance protein
JR441_07190	COG2076	Multidrug Resistance protein
JR441_07195	COG0788	formyltetrahydrofolate deformylase activity
JR441_07200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JR441_07205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JR441_07210	COG1764	response to oxidative stress
JR441_07215	COG1846	Transcriptional regulator
JR441_07220	COG1764	response to oxidative stress
JR441_07225	COG0590	tRNA wobble adenosine to inosine editing
JR441_07230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JR441_07235	COG1404	Belongs to the peptidase S8 family
JR441_07240	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_07245	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JR441_07250	COG1122	ATPase activity
JR441_07255	COG4721	ABC-type cobalt transport system, permease component
JR441_07265	COG0745	RESPONSE REGULATOR receiver
JR441_07270	COG3850	Histidine kinase
JR441_07270	COG5002	protein histidine kinase activity
JR441_07275	COG3212	peptidase
JR441_07280	COG3212	peptidase
JR441_07290	COG2239	Acts as a magnesium transporter
JR441_07295	COG0789	Transcriptional regulator
JR441_07310	COG1846	Transcriptional regulator
JR441_07315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR441_07320	COG0726	polysaccharide deacetylase
JR441_07325	COG1408	metallophosphoesterase
JR441_07335	COG0463	Glycosyl transferase, family 2
JR441_07340	COG3285	dna ligase
JR441_07340	COG1793	dna ligase
JR441_07345	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
JR441_07355	COG0586	Pfam SNARE associated Golgi protein
JR441_07360	COG0861	Integral membrane protein TerC family
JR441_07365	COG1191	sigma factor activity
JR441_07385	COG0501	Belongs to the peptidase M48B family
JR441_07390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JR441_07405	COG3594	Acyltransferase
JR441_07410	COG5002	protein histidine kinase activity
JR441_07415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JR441_07425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JR441_07430	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
JR441_07435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JR441_07440	COG0436	Aminotransferase
JR441_07445	COG1850	ribulose-bisphosphate carboxylase activity
JR441_07450	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
JR441_07455	COG0235	Class ii aldolase
JR441_07460	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
JR441_07465	COG3339	Conserved Protein
JR441_07480	COG3852	Histidine kinase
JR441_07485	COG1846	Transcriptional regulator
JR441_07490	COG1360	Flagellar Motor Protein
JR441_07495	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JR441_07500	COG0542	response to heat
JR441_07505	COG3949	Membrane
JR441_07510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JR441_07515	COG0720	synthase
JR441_07520	COG0602	queuosine metabolic process
JR441_07525	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JR441_07535	COG1733	regulation of RNA biosynthetic process
JR441_07540	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_07545	COG4641	Protein conserved in bacteria
JR441_07545	COG1388	LysM domain
JR441_07550	COG1388	LysM domain
JR441_07555	COG3858	chitin binding
JR441_07565	COG4873	Protein conserved in bacteria
JR441_07575	COG3773	Cell wall hydrolase
JR441_07580	COG2244	polysaccharide biosynthetic process
JR441_07585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_07590	COG2217	Heavy metal translocating P-type atpase
JR441_07600	COG0006	proline dipeptidase activity
JR441_07605	COG1609	Transcriptional regulator
JR441_07610	COG3711	transcriptional antiterminator
JR441_07615	COG2190	(PTS) system
JR441_07615	COG1263	PTS System
JR441_07615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_07620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_07625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JR441_07635	COG1533	DNA photolyase activity
JR441_07640	COG0456	acetyltransferase
JR441_07645	COG0840	transmembrane signaling receptor activity
JR441_07650	COG2084	Dehydrogenase
JR441_07655	COG2340	Cysteine-rich secretory protein family
JR441_07660	COG0768	penicillin binding
JR441_07665	COG4191	Histidine kinase
JR441_07670	COG0436	Aminotransferase
JR441_07680	COG0784	Response regulator, receiver
JR441_07680	COG0835	chemotaxis
JR441_07690	COG2814	Major facilitator Superfamily
JR441_07695	COG1376	ErfK ybiS ycfS ynhG family protein
JR441_07700	COG1408	metallophosphoesterase
JR441_07705	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_07710	COG2200	EAL domain
JR441_07715	COG4703	Protein of unknown function (DUF1797)
JR441_07720	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
JR441_07730	COG0517	IMP dehydrogenase activity
JR441_07735	COG0583	DNA-binding transcription factor activity
JR441_07740	COG0716	FMN binding
JR441_07750	COG0716	FMN binding
JR441_07755	COG2171	N-acyltransferase activity
JR441_07760	COG1473	amidohydrolase
JR441_07770	COG0668	transmembrane transport
JR441_07775	COG0450	alkyl hydroperoxide reductase
JR441_07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_07795	COG0746	molybdenum cofactor guanylyltransferase activity
JR441_07800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JR441_07805	COG0303	'Molybdopterin
JR441_07810	COG1763	Mo-molybdopterin cofactor biosynthetic process
JR441_07815	COG0314	molybdopterin synthase activity
JR441_07820	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JR441_07825	COG1132	(ABC) transporter
JR441_07830	COG1132	(ABC) transporter
JR441_07840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JR441_07845	COG1136	(ABC) transporter
JR441_07850	COG0577	efflux transmembrane transporter activity
JR441_07855	COG1349	DNA-binding transcription factor activity
JR441_07860	COG1105	Belongs to the carbohydrate kinase PfkB family
JR441_07865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_07865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JR441_07865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_07870	COG0681	Belongs to the peptidase S26 family
JR441_07880	COG0488	(ABC) transporter
JR441_07885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JR441_07890	COG2309	aminopeptidase activity
JR441_07900	COG1077	Cell shape determining protein MreB Mrl
JR441_07905	COG2002	toxin-antitoxin pair type II binding
JR441_07910	COG3852	Histidine kinase
JR441_07915	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
JR441_07915	COG2105	PFAM AIG2 family protein
JR441_07920	COG0569	domain protein
JR441_07925	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JR441_07930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JR441_07935	COG5503	Protein of unknown function (DUF1447)
JR441_07940	COG0561	phosphatase activity
JR441_07945	COG0242	peptide deformylase activity
JR441_07955	COG0497	DNA recombination
JR441_07960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JR441_07965	COG0022	dehydrogenase e1 component
JR441_07970	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JR441_07980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_07990	COG1982	Orn Lys Arg decarboxylase major
JR441_07995	COG4476	Belongs to the UPF0223 family
JR441_08000	COG4493	Belongs to the UPF0637 family
JR441_08010	COG0483	inositol monophosphate 1-phosphatase activity
JR441_08020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JR441_08040	COG1595	DNA-templated transcription, initiation
JR441_08060	COG1217	gtp-binding protein TYPA
JR441_08070	COG4896	Protein conserved in bacteria
JR441_08080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JR441_08085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JR441_08090	COG2066	Belongs to the glutaminase family
JR441_08095	COG4838	Belongs to the UPF0358 family
JR441_08100	COG0772	Belongs to the SEDS family
JR441_08105	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JR441_08110	COG1612	heme a metabolic process
JR441_08115	COG0109	protoheme IX farnesyltransferase activity
JR441_08120	COG2010	Cytochrome c
JR441_08120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JR441_08125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JR441_08130	COG1845	cytochrome c oxidase, subunit III
JR441_08135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JR441_08140	COG3336	cytochrome c oxidase
JR441_08150	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
JR441_08155	COG2340	Cysteine-rich secretory protein family
JR441_08170	COG3679	Belongs to the UPF0342 family
JR441_08175	COG4471	UPF0298 protein
JR441_08180	COG0742	ribosomal rna small subunit methyltransferase
JR441_08185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JR441_08190	COG3314	Sporulation integral membrane protein YlbJ
JR441_08195	COG1752	Esterase of the alpha-beta hydrolase superfamily
JR441_08200	COG3480	Lon protease (S16) C-terminal proteolytic domain
JR441_08205	COG1323	Belongs to the UPF0348 family
JR441_08215	COG1399	metal-binding, possibly nucleic acid-binding protein
JR441_08230	COG0454	-acetyltransferase
JR441_08235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JR441_08240	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JR441_08245	COG2001	Belongs to the MraZ family
JR441_08250	COG0275	rRNA processing
JR441_08255	COG4839	cell division protein FtsL
JR441_08260	COG0768	penicillin binding
JR441_08265	COG0768	penicillin binding
JR441_08270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JR441_08275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JR441_08280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JR441_08285	COG0772	Belongs to the SEDS family
JR441_08290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR441_08295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JR441_08300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JR441_08305	COG3879	Bacterial protein of unknown function (DUF881)
JR441_08310	COG3879	Bacterial protein of unknown function (DUF881)
JR441_08315	COG3856	small basic protein
JR441_08320	COG0849	cell division
JR441_08325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JR441_08330	COG1404	Belongs to the peptidase S8 family
JR441_08330	COG4412	M6 family metalloprotease domain protein
JR441_08340	COG1191	sigma factor activity
JR441_08345	COG1191	sigma factor activity
JR441_08350	COG1119	ATPase activity
JR441_08355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_08360	COG1873	PFAM PRC-barrel domain
JR441_08365	COG1496	oxidoreductase activity
JR441_08370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JR441_08375	COG1799	cell septum assembly
JR441_08380	COG0762	integral membrane protein
JR441_08385	COG2302	S4 RNA-binding domain
JR441_08390	COG3599	regulation of cell shape
JR441_08395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JR441_08400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JR441_08405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JR441_08410	COG0564	pseudouridine synthase activity
JR441_08415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JR441_08420	COG2233	PERMEase
JR441_08425	COG0540	Belongs to the ATCase OTCase family
JR441_08430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JR441_08435	COG0505	Belongs to the CarA family
JR441_08440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JR441_08445	COG0543	2 iron, 2 sulfur cluster binding
JR441_08450	COG0167	dihydroorotate dehydrogenase activity
JR441_08455	COG0284	orotidine-5'-phosphate decarboxylase activity
JR441_08460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JR441_08465	COG0175	sulfate reduction
JR441_08470	COG0306	phosphate transporter
JR441_08475	COG2046	Belongs to the sulfate adenylyltransferase family
JR441_08480	COG0529	Catalyzes the synthesis of activated sulfate
JR441_08485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JR441_08490	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
JR441_08495	COG1648	precorrin-2 dehydrogenase activity
JR441_08500	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JR441_08505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JR441_08510	COG1561	YicC-like family, N-terminal region
JR441_08520	COG0194	GDP metabolic process
JR441_08525	COG1758	RNA polymerase activity
JR441_08530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JR441_08535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JR441_08540	COG0242	peptide deformylase activity
JR441_08545	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JR441_08550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JR441_08550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JR441_08555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JR441_08560	COG0631	protein serine/threonine phosphatase activity
JR441_08565	COG0515	serine threonine protein kinase
JR441_08565	COG2815	serine threonine protein kinase
JR441_08570	COG1162	GTPase activity
JR441_08575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JR441_08580	COG1564	THIamine pyrophosphokinase
JR441_08590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JR441_08595	COG1302	Protein conserved in bacteria
JR441_08600	COG1461	Dihydroxyacetone kinase
JR441_08605	COG1760	l-serine dehydratase
JR441_08610	COG1760	l-serine dehydratase
JR441_08615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JR441_08620	COG2050	protein possibly involved in aromatic compounds catabolism
JR441_08620	COG1349	DNA-binding transcription factor activity
JR441_08625	COG0416	fatty acid biosynthetic process
JR441_08630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JR441_08635	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_08645	COG0571	ribonuclease III activity
JR441_08650	COG1196	nuclear chromosome segregation
JR441_08655	COG0552	protein localization to endoplasmic reticulum
JR441_08665	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JR441_08670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JR441_08675	COG0228	four-way junction DNA binding
JR441_08680	COG1837	Belongs to the UPF0109 family
JR441_08690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JR441_08695	COG0336	Belongs to the RNA methyltransferase TrmD family
JR441_08700	COG0335	large ribosomal subunit rRNA binding
JR441_08705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JR441_08710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JR441_08720	COG2257	FlhB HrpN YscU SpaS Family
JR441_08725	COG0045	succinate-CoA ligase (ADP-forming) activity
JR441_08730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JR441_08735	COG0758	DNA mediated transformation
JR441_08740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JR441_08745	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JR441_08750	COG4974	Belongs to the 'phage' integrase family
JR441_08755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JR441_08760	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JR441_08765	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JR441_08770	COG1815	bacterial-type flagellum-dependent cell motility
JR441_08775	COG1558	bacterial-type flagellum-dependent cell motility
JR441_08780	COG1677	Flagellar hook-basal body complex protein FliE
JR441_08785	COG1766	The M ring may be actively involved in energy transduction
JR441_08790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JR441_08795	COG1317	bacterial-type flagellum organization
JR441_08800	COG1157	protein secretion by the type III secretion system
JR441_08805	COG2882	bacterial-type flagellum organization
JR441_08810	COG3334	PFAM MgtE intracellular
JR441_08815	COG3144	bacterial-type flagellum assembly
JR441_08820	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JR441_08825	COG4786	Flagellar basal body rod
JR441_08830	COG1582	Flagellar protein (FlbD)
JR441_08835	COG1580	Controls the rotational direction of flagella during chemotaxis
JR441_08840	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JR441_08845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JR441_08845	COG1776	CheC inhibitor of MCP methylation
JR441_08850	COG2201	protein-glutamate methylesterase activity
JR441_08855	COG3190	flagellar
JR441_08860	COG1338	Plays a role in the flagellum-specific transport system
JR441_08865	COG1987	bacterial-type flagellum assembly
JR441_08870	COG1684	flagellar biosynthetic protein fliR
JR441_08875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JR441_08880	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JR441_08885	COG1419	protein localization to endoplasmic reticulum
JR441_08890	COG0455	bacterial-type flagellum organization
JR441_08895	COG2201	protein-glutamate methylesterase activity
JR441_08900	COG2198	Histidine kinase
JR441_08900	COG0643	Histidine kinase
JR441_08905	COG0835	chemotaxis
JR441_08910	COG1776	CheC inhibitor of MCP methylation
JR441_08915	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
JR441_08920	COG1191	sigma factor activity
JR441_08930	COG0052	Belongs to the universal ribosomal protein uS2 family
JR441_08935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JR441_08940	COG0528	UMP kinase activity
JR441_08945	COG0233	cytoplasmic translational termination
JR441_08950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JR441_08955	COG4589	Belongs to the CDS family
JR441_08960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JR441_08965	COG0750	zinc metalloprotease
JR441_08970	COG0442	prolyl-tRNA aminoacylation
JR441_08975	COG2176	DNA-directed DNA polymerase activity
JR441_08980	COG0779	Required for maturation of 30S ribosomal subunits
JR441_08985	COG0195	Participates in both transcription termination and antitermination
JR441_08990	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JR441_08995	COG1358	cellular component organization or biogenesis
JR441_09000	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JR441_09005	COG1550	Protein conserved in bacteria
JR441_09010	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JR441_09015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JR441_09020	COG0196	riboflavin kinase activity
JR441_09025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JR441_09030	COG1185	polyribonucleotide nucleotidyltransferase activity
JR441_09035	COG0726	polysaccharide deacetylase
JR441_09040	COG0612	Peptidase, M16
JR441_09045	COG1873	PFAM PRC-barrel domain
JR441_09050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JR441_09055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JR441_09060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JR441_09065	COG0527	aspartate kinase activity
JR441_09070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JR441_09075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JR441_09080	COG0740	serine-type endopeptidase activity
JR441_09090	COG1674	ftsk spoiiie
JR441_09090	COG4980	gas vesicle protein
JR441_09095	COG2188	Transcriptional regulator
JR441_09100	COG2814	Major facilitator Superfamily
JR441_09105	COG0612	Peptidase, M16
JR441_09110	COG0612	Peptidase, M16
JR441_09115	COG0300	oxidoreductase activity
JR441_09130	COG1426	Protein conserved in bacteria
JR441_09135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JR441_09140	COG1058	Belongs to the CinA family
JR441_09140	COG1546	Belongs to the CinA family
JR441_09145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JR441_09150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JR441_09155	COG1418	mRNA catabolic process
JR441_09160	COG1692	metallophosphoesterase
JR441_09165	COG2359	stage V sporulation protein S
JR441_09170	COG1063	alcohol dehydrogenase
JR441_09175	COG0156	8-amino-7-oxononanoate synthase activity
JR441_09180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JR441_09185	COG4550	Control of competence regulator ComK, YlbF/YmcA
JR441_09195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JR441_09200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JR441_09215	COG3226	Transcriptional regulator
JR441_09220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_09230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JR441_09235	COG3321	synthase
JR441_09240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JR441_09240	COG2070	2-Nitropropane dioxygenase
JR441_09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_09250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JR441_09255	COG3425	synthase
JR441_09260	COG1024	Enoyl-CoA hydratase
JR441_09265	COG1024	Enoyl-CoA hydratase
JR441_09270	COG0300	oxidoreductase activity
JR441_09270	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_09270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09270	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_09270	COG3321	synthase
JR441_09275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_09275	COG0300	oxidoreductase activity
JR441_09275	COG3321	synthase
JR441_09275	COG4221	oxidoreductase activity
JR441_09280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_09280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_09280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09280	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_09280	COG3321	synthase
JR441_09285	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_09285	COG3321	synthase
JR441_09285	COG4221	oxidoreductase activity
JR441_09285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_09290	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JR441_09290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JR441_09290	COG3321	synthase
JR441_09295	COG2124	cytochrome p450
JR441_09305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_09310	COG1404	Belongs to the peptidase S8 family
JR441_09320	COG4195	phage-related replication protein
JR441_09325	COG1764	response to oxidative stress
JR441_09330	COG2076	Multidrug Resistance protein
JR441_09335	COG2076	Multidrug Resistance protein
JR441_09350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JR441_09355	COG1923	regulation of RNA biosynthetic process
JR441_09370	COG1780	Probably involved in ribonucleotide reductase function
JR441_09375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JR441_09380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JR441_09385	COG4112	unkown
JR441_09390	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_09395	COG0464	growth
JR441_09400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JR441_09405	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JR441_09410	COG0789	Transcriptional regulator
JR441_09415	COG0174	glutamine synthetase
JR441_09430	COG5444	nuclease activity
JR441_09435	COG5444	nuclease activity
JR441_09455	COG0463	Glycosyl transferase, family 2
JR441_09465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_09480	COG3655	Transcriptional regulator
JR441_09510	COG2211	Major facilitator Superfamily
JR441_09515	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_09520	COG1940	carbohydrate kinase activity
JR441_09525	COG2115	Belongs to the xylose isomerase family
JR441_09530	COG1070	Carbohydrate kinase
JR441_09540	COG1525	nuclease
JR441_09545	COG2814	Major facilitator Superfamily
JR441_09550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JR441_09560	COG0756	dUTP diphosphatase activity
JR441_09575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JR441_09605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JR441_09615	COG3832	glyoxalase III activity
JR441_09630	COG0697	spore germination
JR441_09635	COG0531	amino acid
JR441_09665	COG4195	phage-related replication protein
JR441_09675	COG0346	lactoylglutathione lyase activity
JR441_09680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JR441_09685	COG1388	LysM domain
JR441_09690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JR441_09695	COG4224	UPF0291 protein
JR441_09700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JR441_09710	COG3763	UPF0154 protein
JR441_09720	COG0785	Cytochrome C biogenesis protein
JR441_09725	COG2201	protein-glutamate methylesterase activity
JR441_09730	COG4846	Membrane protein involved in cytochrome C biogenesis
JR441_09740	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_09755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JR441_09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_09780	COG0824	Thioesterase
JR441_09790	COG4841	protein insertion into membrane
JR441_09795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JR441_09800	COG1832	CoA-binding protein
JR441_09805	COG0187	DNA topoisomerase II activity
JR441_09810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JR441_09820	COG1115	amino acid carrier protein
JR441_09825	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
JR441_09835	COG5520	Belongs to the glycosyl hydrolase 30 family
JR441_09840	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_09845	COG2246	polysaccharide biosynthetic process
JR441_09850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JR441_09855	COG0586	Pfam SNARE associated Golgi protein
JR441_09860	COG2404	hydrolase activity, acting on ester bonds
JR441_09865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JR441_09870	COG1024	Enoyl-CoA hydratase
JR441_09875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JR441_09880	COG0511	ligase activity, forming carbon-carbon bonds
JR441_09885	COG0439	Biotin carboxylase
JR441_09890	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_09895	COG1960	acyl-CoA dehydrogenase activity
JR441_09910	COG1649	PFAM Uncharacterised BCR, COG1649
JR441_09920	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JR441_09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_09945	COG2027	D-alanyl-D-alanine carboxypeptidase
JR441_09950	COG2017	converts alpha-aldose to the beta-anomer
JR441_09955	COG0534	Mate efflux family protein
JR441_09970	COG0582	viral genome integration into host DNA
JR441_09975	COG0166	Belongs to the GPI family
JR441_09980	COG0405	Gamma-glutamyltransferase
JR441_09985	COG0583	DNA-binding transcription factor activity
JR441_09990	COG0604	alcohol dehydrogenase
JR441_09995	COG0493	'glutamate synthase
JR441_10000	COG0070	glutamate synthase
JR441_10000	COG0069	glutamate synthase activity
JR441_10000	COG0067	glutamate synthase
JR441_10005	COG0583	DNA-binding transcription factor activity
JR441_10010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JR441_10015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_10025	COG0300	oxidoreductase activity
JR441_10030	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JR441_10040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JR441_10045	COG2814	Major facilitator Superfamily
JR441_10050	COG1070	Carbohydrate kinase
JR441_10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JR441_10060	COG0243	molybdopterin cofactor binding
JR441_10090	COG5278	phosphoserine phosphatase activity
JR441_10090	COG0840	transmembrane signaling receptor activity
JR441_10095	COG2368	4-hydroxyphenylacetate
JR441_10100	COG4305	rare lipoprotein A
JR441_10105	COG3619	membrane
JR441_10110	COG3866	Pectate lyase
JR441_10115	COG2135	peptidase activity
JR441_10125	COG2140	Oxalate decarboxylase
JR441_10140	COG0456	acetyltransferase
JR441_10160	COG2720	vancomycin resistance protein
JR441_10170	COG3655	Transcriptional regulator
JR441_10175	COG3739	integral membrane protein
JR441_10180	COG0583	DNA-binding transcription factor activity
JR441_10185	COG0697	spore germination
JR441_10195	COG0693	protein deglycase activity
JR441_10200	COG2367	Beta-lactamase
JR441_10220	COG0574	Belongs to the PEP-utilizing enzyme family
JR441_10220	COG3848	Pyruvate phosphate dikinase
JR441_10225	COG0726	polysaccharide deacetylase
JR441_10275	COG2723	6-phospho-beta-galactosidase activity
JR441_10290	COG0395	ABC-type sugar transport system, permease component
JR441_10295	COG1175	transmembrane transport
JR441_10305	COG1940	carbohydrate kinase activity
JR441_10315	COG5444	nuclease activity
JR441_10320	COG4282	regulation of fungal-type cell wall biogenesis
JR441_10325	COG1231	oxidoreductase activity
JR441_10330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_10335	COG2207	Transcriptional regulator
JR441_10335	COG0662	Cupin 2, conserved barrel domain protein
JR441_10340	COG0456	acetyltransferase
JR441_10345	COG1309	transcriptional regulator
JR441_10350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_10355	COG3708	Transcriptional regulator
JR441_10360	COG2378	regulation of single-species biofilm formation
JR441_10370	COG0640	Transcriptional regulator
JR441_10375	COG0741	lytic transglycosylase activity
JR441_10380	COG2322	membrane
JR441_10400	COG3239	Fatty acid desaturase
JR441_10405	COG4585	Histidine kinase
JR441_10410	COG2197	response regulator
JR441_10415	COG3584	3D domain protein
JR441_10415	COG1388	LysM domain
JR441_10420	COG0514	ATP-dependent DNA helicase (RecQ)
JR441_10430	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JR441_10435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JR441_10450	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_10475	COG1012	belongs to the aldehyde dehydrogenase family
JR441_10480	COG1657	PFAM Prenyltransferase squalene oxidase
JR441_10485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JR441_10490	COG0733	neurotransmitter:sodium symporter activity
JR441_10495	COG0385	Bile acid
JR441_10500	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_10505	COG0567	Dehydrogenase, E1 component
JR441_10510	COG4548	von Willebrand factor, type A
JR441_10515	COG0714	Associated with various cellular activities
JR441_10520	COG2032	superoxide dismutase activity
JR441_10525	COG0791	NLP P60 protein
JR441_10525	COG1388	LysM domain
JR441_10530	COG1819	glycosyl
JR441_10535	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JR441_10540	COG0534	Mate efflux family protein
JR441_10545	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_10550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_10555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_10565	COG2962	Rard protein
JR441_10580	COG2610	gluconate transmembrane transporter activity
JR441_10585	COG1942	4-Oxalocrotonate Tautomerase
JR441_10590	COG1733	regulation of RNA biosynthetic process
JR441_10595	COG0778	Nitroreductase
JR441_10600	COG0400	carboxylic ester hydrolase activity
JR441_10605	COG0346	lactoylglutathione lyase activity
JR441_10615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_10620	COG3409	Peptidoglycan-binding domain 1 protein
JR441_10620	COG0793	Belongs to the peptidase S41A family
JR441_10625	COG2226	methyltransferase
JR441_10635	COG1876	peptidase activity
JR441_10640	COG0813	purine-nucleoside phosphorylase activity
JR441_10655	COG0671	phosphoesterase, PA-phosphatase related
JR441_10675	COG4479	Belongs to the UPF0346 family
JR441_10685	COG1509	lysine 2,3-aminomutase activity
JR441_10690	COG0456	acetyltransferase
JR441_10695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_10700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JR441_10705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JR441_10710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JR441_10725	COG0456	acetyltransferase
JR441_10730	COG0463	Glycosyl transferase, family 2
JR441_10745	COG4641	Protein conserved in bacteria
JR441_10750	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
JR441_10755	COG1086	Polysaccharide biosynthesis protein
JR441_10760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JR441_10765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JR441_10770	COG1846	Transcriptional regulator
JR441_10775	COG0534	Mate efflux family protein
JR441_10785	COG4698	Protein conserved in bacteria
JR441_10790	COG2755	lipolytic protein G-D-S-L family
JR441_10795	COG1999	signal sequence binding
JR441_10805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JR441_10810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JR441_10815	COG1272	protein, Hemolysin III
JR441_10820	COG0204	Acyl-transferase
JR441_10825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JR441_10830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JR441_10835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JR441_10845	COG2136	Putative SAM-dependent methyltransferase
JR441_10845	COG2521	methyltransferase
JR441_10855	COG0129	dihydroxy-acid dehydratase activity
JR441_10860	COG1413	lyase activity
JR441_10865	COG1418	mRNA catabolic process
JR441_10870	COG0386	Belongs to the glutathione peroxidase family
JR441_10875	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JR441_10880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JR441_10890	COG1278	Cold shock
JR441_10910	COG0328	RNA-DNA hybrid ribonuclease activity
JR441_10915	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JR441_10920	COG0328	RNA-DNA hybrid ribonuclease activity
JR441_10930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JR441_10945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JR441_10955	COG1755	Isoprenylcysteine carboxyl methyltransferase
JR441_10960	COG3424	synthase
JR441_10965	COG2233	PERMEase
JR441_10970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JR441_10975	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JR441_10985	COG0800	Aldolase
JR441_10990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_10995	COG1609	Transcriptional regulator
JR441_11000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
JR441_11005	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_11010	COG1199	ATP-dependent helicase activity
JR441_11025	COG0116	Belongs to the methyltransferase superfamily
JR441_11040	COG4474	Belongs to the UPF0398 family
JR441_11055	COG3359	exonuclease
JR441_11060	COG1205	dead DEAH box helicase
JR441_11060	COG1111	helicase
JR441_11065	COG2190	(PTS) system
JR441_11070	COG0071	Belongs to the small heat shock protein (HSP20) family
JR441_11105	COG3331	DNA recombination
JR441_11110	COG4499	WXG100 protein secretion system (Wss), protein YukC
JR441_11110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_11120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JR441_11125	COG3935	DnaD domain protein
JR441_11130	COG0017	Asparaginyl-tRNA synthetase
JR441_11135	COG0436	Aminotransferase
JR441_11140	COG5353	protein conserved in bacteria
JR441_11150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JR441_11150	COG1199	ATP-dependent helicase activity
JR441_11155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JR441_11160	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JR441_11165	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JR441_11170	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JR441_11170	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JR441_11175	COG0617	tRNA 3'-terminal CCA addition
JR441_11180	COG0438	transferase activity, transferring glycosyl groups
JR441_11185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_11190	COG1803	Methylglyoxal synthase
JR441_11195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JR441_11200	COG1694	Mazg nucleotide pyrophosphohydrolase
JR441_11205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_11215	COG4347	Protein of unknown function (DUF1405)
JR441_11220	COG2010	Cytochrome c
JR441_11220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JR441_11225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JR441_11230	COG0723	plastoquinol--plastocyanin reductase activity
JR441_11240	COG5582	Belongs to the UPF0302 family
JR441_11245	COG0457	Tetratricopeptide repeat
JR441_11250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JR441_11255	COG0287	Prephenate dehydrogenase
JR441_11265	COG0159	tryptophan synthase activity
JR441_11270	COG0133	tryptophan synthase activity
JR441_11275	COG0135	phosphoribosylanthranilate isomerase activity
JR441_11285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JR441_11290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JR441_11295	COG4401	Chorismate mutase type I
JR441_11300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JR441_11305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JR441_11310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JR441_11315	COG0105	UTP biosynthetic process
JR441_11320	COG0142	geranyltranstransferase activity
JR441_11325	COG2226	methyltransferase
JR441_11330	COG0142	geranyltranstransferase activity
JR441_11340	COG0302	gtp cyclohydrolase
JR441_11345	COG0776	regulation of translation
JR441_11350	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JR441_11365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JR441_11370	COG1160	GTP binding
JR441_11395	COG1304	FMN binding
JR441_11400	COG0539	negative regulation of cytoplasmic translation
JR441_11405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JR441_11415	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
JR441_11420	COG2959	enzyme of heme biosynthesis
JR441_11425	COG3409	Peptidoglycan-binding domain 1 protein
JR441_11425	COG3773	Cell wall hydrolase
JR441_11430	COG2339	peptidase activity
JR441_11435	COG0492	ferredoxin-NADP+ reductase activity
JR441_11440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JR441_11445	COG4862	establishment of competence for transformation
JR441_11450	COG1408	metallophosphoesterase
JR441_11460	COG1388	LysM domain
JR441_11465	COG1266	CAAX protease self-immunity
JR441_11470	COG0514	ATP-dependent DNA helicase (RecQ)
JR441_11475	COG4955	Helix-turn-helix domain
JR441_11480	COG1141	Ferredoxin
JR441_11485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JR441_11490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JR441_11495	COG0710	3-dehydroquinate dehydratase activity
JR441_11505	COG1595	DNA-templated transcription, initiation
JR441_11510	COG5002	protein histidine kinase activity
JR441_11515	COG0745	RESPONSE REGULATOR receiver
JR441_11520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JR441_11525	COG1333	cytochrome c biogenesis protein
JR441_11530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_11535	COG1187	pseudouridine synthase activity
JR441_11540	COG0700	Nucleoside recognition
JR441_11545	COG2715	membrane protein required for spore maturation
JR441_11550	COG1686	Belongs to the peptidase S11 family
JR441_11560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JR441_11565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JR441_11570	COG1547	Domain of unknown function (DUF309)
JR441_11575	COG0456	acetyltransferase
JR441_11580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JR441_11585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR441_11585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JR441_11590	COG0307	riboflavin synthase, alpha
JR441_11595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JR441_11595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JR441_11605	COG0681	Belongs to the peptidase S26 family
JR441_11615	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
JR441_11640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JR441_11645	COG4086	secreted protein
JR441_11650	COG0019	diaminopimelate decarboxylase activity
JR441_11655	COG0697	spore germination
JR441_11670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JR441_11690	COG1191	sigma factor activity
JR441_11695	COG2172	sigma factor antagonist activity
JR441_11700	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_11705	COG1686	Belongs to the peptidase S11 family
JR441_11710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JR441_11715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JR441_11720	COG4974	Belongs to the 'phage' integrase family
JR441_11730	COG0735	belongs to the Fur family
JR441_11735	COG1300	Membrane
JR441_11745	COG0281	malic enzyme
JR441_11750	COG1757	Na H antiporter
JR441_11755	COG1027	Aspartate ammonia-lyase
JR441_11760	COG0252	asparaginase activity
JR441_11765	COG1396	sequence-specific DNA binding
JR441_11770	COG1379	DNA repair
JR441_11775	COG0494	nUDIX hydrolase
JR441_11785	COG0667	Aldo Keto reductase
JR441_11795	COG1073	alpha beta
JR441_11805	COG4918	Iron-sulphur cluster biosynthesis
JR441_11810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JR441_11810	COG0456	acetyltransferase
JR441_11815	COG2329	Antibiotic biosynthesis monooxygenase
JR441_11820	COG0456	acetyltransferase
JR441_11830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JR441_11840	COG2211	Major facilitator Superfamily
JR441_11850	COG0346	lactoylglutathione lyase activity
JR441_11855	COG1072	(Pantothenic acid kinase))
JR441_11860	COG3048	D-serine ammonia-lyase activity
JR441_11865	COG0300	oxidoreductase activity
JR441_11870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_11875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_11880	COG4187	Peptidase family M20/M25/M40
JR441_11885	COG1902	pentaerythritol trinitrate reductase activity
JR441_11890	COG0596	Alpha beta hydrolase
JR441_11900	COG1234	tRNA 3'-trailer cleavage
JR441_11905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JR441_11910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JR441_11915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JR441_11925	COG0706	membrane insertase activity
JR441_11930	COG3361	conserved protein (COG2071)
JR441_11935	COG2195	Cleaves the N-terminal amino acid of tripeptides
JR441_11940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JR441_11945	COG0346	lactoylglutathione lyase activity
JR441_11955	COG1376	ErfK ybiS ycfS ynhG family protein
JR441_11960	COG4129	membrane
JR441_11965	COG1126	abc transporter atp-binding protein
JR441_11970	COG0765	amino acid transport
JR441_11975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_11985	COG1597	lipid kinase activity
JR441_11990	COG2814	Major facilitator Superfamily
JR441_11995	COG4978	Transcriptional regulator
JR441_11995	COG0789	Transcriptional regulator
JR441_12000	COG0508	dehydrogenase complex catalyzes the overall conversion of
JR441_12005	COG0022	dehydrogenase e1 component
JR441_12010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JR441_12015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JR441_12020	COG3426	butyrate kinase activity
JR441_12025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JR441_12030	COG0280	phosphate acetyltransferase
JR441_12035	COG3829	transcription factor binding
JR441_12035	COG3290	protein histidine kinase activity
JR441_12045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JR441_12050	COG2079	MmgE PrpD family protein
JR441_12055	COG0372	Belongs to the citrate synthase family
JR441_12060	COG1960	acyl-CoA dehydrogenase activity
JR441_12065	COG1250	3-hydroxyacyl-CoA dehydrogenase
JR441_12070	COG0183	Belongs to the thiolase family
JR441_12075	COG0584	glycerophosphoryl diester phosphodiesterase
JR441_12080	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_12095	COG1902	pentaerythritol trinitrate reductase activity
JR441_12100	COG0745	RESPONSE REGULATOR receiver
JR441_12105	COG0750	zinc metalloprotease
JR441_12110	COG0497	DNA recombination
JR441_12115	COG1438	arginine binding
JR441_12120	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JR441_12125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JR441_12130	COG0142	geranyltranstransferase activity
JR441_12135	COG1722	exodeoxyribonuclease VII activity
JR441_12140	COG1570	exodeoxyribonuclease VII activity
JR441_12145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JR441_12150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JR441_12155	COG1302	Protein conserved in bacteria
JR441_12160	COG0439	Biotin carboxylase
JR441_12165	COG0511	ligase activity, forming carbon-carbon bonds
JR441_12205	COG3854	ATPases associated with a variety of cellular activities
JR441_12215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JR441_12220	COG0006	proline dipeptidase activity
JR441_12225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JR441_12235	COG3872	metal-dependent enzyme
JR441_12245	COG1752	Esterase of the alpha-beta hydrolase superfamily
JR441_12250	COG1321	iron dependent repressor
JR441_12255	COG0095	Lipoate-protein ligase
JR441_12260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_12265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JR441_12270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JR441_12275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JR441_12280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JR441_12295	COG1396	sequence-specific DNA binding
JR441_12305	COG0681	Belongs to the peptidase S26 family
JR441_12330	COG4940	Competence protein ComGF
JR441_12340	COG4970	Tfp pilus assembly protein FimT
JR441_12345	COG4537	Required for transformation and DNA binding
JR441_12350	COG1459	type II secretion system
JR441_12355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JR441_12360	COG0517	IMP dehydrogenase activity
JR441_12365	COG0598	Magnesium transport protein CorA
JR441_12370	COG1253	flavin adenine dinucleotide binding
JR441_12375	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_12385	COG1393	Belongs to the ArsC family
JR441_12395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_12405	COG0011	TIGRFAM Protein of
JR441_12415	COG2866	Carboxypeptidase
JR441_12420	COG1368	sulfuric ester hydrolase activity
JR441_12425	COG1940	carbohydrate kinase activity
JR441_12430	COG4483	Protein conserved in bacteria
JR441_12435	COG0457	Tetratricopeptide repeat
JR441_12435	COG0705	Rhomboid family
JR441_12445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JR441_12455	COG0438	transferase activity, transferring glycosyl groups
JR441_12470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JR441_12475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JR441_12480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JR441_12485	COG0581	inorganic phosphate transmembrane transporter activity
JR441_12490	COG0573	inorganic phosphate transmembrane transporter activity
JR441_12495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JR441_12500	COG0768	penicillin binding
JR441_12505	COG0477	Major facilitator Superfamily
JR441_12510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JR441_12515	COG2839	Protein conserved in bacteria
JR441_12520	COG5521	maltodextrose utilization protein MalA
JR441_12525	COG1388	LysM domain
JR441_12530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JR441_12535	COG4709	membrane
JR441_12540	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
JR441_12545	COG0735	belongs to the Fur family
JR441_12550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_12560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JR441_12565	COG0513	Belongs to the DEAD box helicase family
JR441_12575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JR441_12580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JR441_12585	COG2384	SAM-dependent methyltransferase
JR441_12590	COG2010	Cytochrome c
JR441_12595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JR441_12600	COG0358	DNA primase activity
JR441_12605	COG1671	Belongs to the UPF0178 family
JR441_12610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JR441_12615	COG0517	IMP dehydrogenase activity
JR441_12620	COG0751	glycine-tRNA ligase activity
JR441_12625	COG0752	glycyl-tRNA synthetase alpha subunit
JR441_12630	COG1381	Involved in DNA repair and RecF pathway recombination
JR441_12640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JR441_12645	COG0295	cytidine deaminase activity
JR441_12650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JR441_12655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JR441_12660	COG1480	7TM receptor with intracellular HD hydrolase
JR441_12665	COG1702	phosphate starvation-inducible protein PhoH
JR441_12670	COG0561	phosphatase activity
JR441_12685	COG4864	UPF0365 protein
JR441_12690	COG1030	water channel activity
JR441_12695	COG1610	YqeY-like protein
JR441_12705	COG1283	sodium-dependent phosphate transmembrane transporter activity
JR441_12710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JR441_12715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JR441_12720	COG2264	protein methyltransferase activity
JR441_12725	COG0484	heat shock protein binding
JR441_12730	COG0443	Heat shock 70 kDa protein
JR441_12735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JR441_12740	COG1420	regulation of RNA biosynthetic process
JR441_12745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JR441_12750	COG0481	GTPase activity
JR441_12760	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_12765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JR441_12770	COG0268	Binds directly to 16S ribosomal RNA
JR441_12775	COG1466	dna polymerase III delta subunit
JR441_12790	COG0658	competence protein
JR441_12790	COG2333	competence protein COMEC
JR441_12795	COG2131	deaminase
JR441_12800	COG1555	photosystem II stabilization
JR441_12800	COG1596	polysaccharide export
JR441_12805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JR441_12810	COG2226	methyltransferase
JR441_12815	COG0799	negative regulation of ribosome biogenesis
JR441_12820	COG1713	HD superfamily hydrolase involved in NAD metabolism
JR441_12825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JR441_12830	COG1534	Rna-binding protein
JR441_12835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JR441_12840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JR441_12845	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JR441_12855	COG2755	lipolytic protein G-D-S-L family
JR441_12860	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_12860	COG3409	Peptidoglycan-binding domain 1 protein
JR441_12865	COG0398	Pfam SNARE associated Golgi protein
JR441_12870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JR441_12880	COG3209	COG3209 Rhs family protein
JR441_12890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JR441_12895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR441_12900	COG0798	PFAM Bile acid sodium symporter
JR441_12905	COG0346	lactoylglutathione lyase activity
JR441_12910	COG0640	Transcriptional regulator
JR441_12915	COG3403	YqcI/YcgG family
JR441_12935	COG0604	alcohol dehydrogenase
JR441_12960	COG0457	Tetratricopeptide repeat
JR441_12975	COG5444	nuclease activity
JR441_13000	COG3409	Peptidoglycan-binding domain 1 protein
JR441_13000	COG5632	N-Acetylmuramoyl-L-alanine amidase
JR441_13005	COG4824	toxin secretion phage lysis holin
JR441_13035	COG3778	Protein conserved in bacteria
JR441_13040	COG3299	homolog of phage Mu protein gp47
JR441_13045	COG3628	GPW Gp25 family protein
JR441_13055	COG4193	domain, Protein
JR441_13060	COG1652	LysM domain
JR441_13065	COG3953	SLT domain
JR441_13065	COG5280	Phage tail tape measure protein TP901
JR441_13120	COG4653	Phage capsid family
JR441_13125	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JR441_13135	COG2369	cell adhesion
JR441_13140	COG5518	Phage portal protein
JR441_13145	COG1783	phage Terminase large subunit
JR441_13150	COG5484	DNA packaging
JR441_13160	COG3677	Transposase
JR441_13175	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
JR441_13185	COG1484	DNA-dependent DNA replication
JR441_13190	COG3935	DnaD domain protein
JR441_13195	COG3723	Recombinational DNA repair protein, rece pathway
JR441_13200	COG5377	YqaJ viral recombinase family
JR441_13230	COG1476	TRANSCRIPTIONal
JR441_13235	COG3620	sequence-specific DNA binding
JR441_13245	COG0563	adenylate kinase activity
JR441_13250	COG2856	Zn peptidase
JR441_13270	COG4124	Belongs to the glycosyl hydrolase 26 family
JR441_13275	COG0730	response to heat
JR441_13280	COG0425	Belongs to the sulfur carrier protein TusA family
JR441_13285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_13285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_13295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_13295	COG0425	Belongs to the sulfur carrier protein TusA family
JR441_13300	COG2210	Belongs to the sulfur carrier protein TusA family
JR441_13305	COG1937	Protein conserved in bacteria
JR441_13310	COG0662	Cupin 2, conserved barrel domain protein
JR441_13320	COG0789	Transcriptional regulator
JR441_13320	COG4978	Transcriptional regulator
JR441_13325	COG2814	Major facilitator Superfamily
JR441_13335	COG1253	flavin adenine dinucleotide binding
JR441_13345	COG0697	spore germination
JR441_13350	COG0583	DNA-binding transcription factor activity
JR441_13355	COG2072	flavoprotein involved in K transport
JR441_13360	COG1230	cation diffusion facilitator family transporter
JR441_13365	COG1942	4-Oxalocrotonate Tautomerase
JR441_13370	COG0583	DNA-binding transcription factor activity
JR441_13380	COG1114	Component of the transport system for branched-chain amino acids
JR441_13385	COG1687	branched-chain amino acid
JR441_13390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JR441_13395	COG1522	sequence-specific DNA binding
JR441_13405	COG2124	cytochrome p450
JR441_13415	COG1335	isochorismatase
JR441_13430	COG2318	DinB family
JR441_13440	COG2070	2-Nitropropane dioxygenase
JR441_13445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JR441_13465	COG3443	Belongs to the bacterial solute-binding protein 9 family
JR441_13470	COG1595	DNA-templated transcription, initiation
JR441_13475	COG0667	Aldo Keto reductase
JR441_13480	COG2851	Citrate transporter
JR441_13485	COG0583	DNA-binding transcription factor activity
JR441_13490	COG2828	Protein conserved in bacteria
JR441_13495	COG3409	Peptidoglycan-binding domain 1 protein
JR441_13500	COG5566	PFAM Mor transcription activator
JR441_13505	COG0596	Alpha beta hydrolase
JR441_13510	COG4991	sh3 domain protein
JR441_13515	COG4991	sh3 domain protein
JR441_13525	COG0346	lactoylglutathione lyase activity
JR441_13535	COG5577	PFAM Coat F domain
JR441_13540	COG1063	alcohol dehydrogenase
JR441_13550	COG5577	PFAM Coat F domain
JR441_13555	COG0789	Transcriptional regulator
JR441_13565	COG1064	alcohol dehydrogenase
JR441_13570	COG0693	protein deglycase activity
JR441_13575	COG1621	beta-fructofuranosidase activity
JR441_13580	COG3716	PTS system mannose fructose sorbose family IID component
JR441_13585	COG3715	PTS system
JR441_13590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_13595	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_13600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JR441_13600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JR441_13610	COG1113	amino acid transport
JR441_13615	COG1280	lysine exporter protein (LysE YggA)
JR441_13620	COG1378	Sugar-specific transcriptional regulator TrmB
JR441_13625	COG1595	DNA-templated transcription, initiation
JR441_13645	COG2124	cytochrome p450
JR441_13645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JR441_13650	COG1309	transcriptional regulator
JR441_13655	COG2226	methyltransferase
JR441_13670	COG2116	formate transmembrane transporter activity
JR441_13675	COG5609	conserved protein (DUF2294)
JR441_13680	COG3383	formate dehydrogenase (NAD+) activity
JR441_13685	COG2427	Protein of unknown function (DUF1641)
JR441_13695	COG0626	cystathionine gamma-synthase activity
JR441_13700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JR441_13705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JR441_13710	COG2226	methyltransferase
JR441_13725	COG0768	penicillin binding
JR441_13730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JR441_13735	COG0572	uridine kinase
JR441_13740	COG0826	peptidase U32
JR441_13745	COG0826	peptidase U32
JR441_13750	COG4122	O-methyltransferase activity
JR441_13755	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JR441_13760	COG3906	Belongs to the UPF0473 family
JR441_13765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JR441_13770	COG4472	Bacterial protein of unknown function (DUF965)
JR441_13775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JR441_13780	COG0628	permease
JR441_13785	COG1126	abc transporter atp-binding protein
JR441_13790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_13795	COG0765	amino acid transport
JR441_13800	COG0765	amino acid transport
JR441_13815	COG3881	PFAM PRC-barrel domain
JR441_13820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JR441_13825	COG0457	Tetratricopeptide repeat
JR441_13830	COG0482	sulfurtransferase activity
JR441_13835	COG1104	cysteine desulfurase activity
JR441_13840	COG1959	2 iron, 2 sulfur cluster binding
JR441_13845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JR441_13850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JR441_13860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JR441_13865	COG0124	histidyl-tRNA synthetase
JR441_13875	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_13875	COG3103	Sh3 type 3 domain protein
JR441_13875	COG4991	sh3 domain protein
JR441_13880	COG1490	D-aminoacyl-tRNA deacylase activity
JR441_13885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JR441_13890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JR441_13895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JR441_13895	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JR441_13900	COG5416	Lipopolysaccharide assembly protein A domain
JR441_13905	COG0490	domain, Protein
JR441_13910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JR441_13910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JR441_13920	COG2244	polysaccharide biosynthetic process
JR441_13925	COG2323	membrane
JR441_13935	COG1862	Preprotein translocase
JR441_13940	COG0343	queuine tRNA-ribosyltransferase activity
JR441_13945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JR441_13955	COG2255	four-way junction helicase activity
JR441_13960	COG0632	four-way junction helicase activity
JR441_13970	COG2814	Major facilitator Superfamily
JR441_13975	COG0673	inositol 2-dehydrogenase activity
JR441_13980	COG2112	serine threonine protein kinase
JR441_14000	COG1115	amino acid carrier protein
JR441_14005	COG0217	transcriptional regulatory protein
JR441_14015	COG1388	LysM domain
JR441_14020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JR441_14025	COG0157	Belongs to the NadC ModD family
JR441_14030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JR441_14035	COG1104	cysteine desulfurase activity
JR441_14040	COG1827	regulation of RNA biosynthetic process
JR441_14045	COG0077	Prephenate dehydratase
JR441_14050	COG4492	Belongs to the UPF0735 family
JR441_14055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JR441_14060	COG3290	protein histidine kinase activity
JR441_14070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JR441_14075	COG2868	ribosomal protein
JR441_14080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JR441_14085	COG1994	Peptidase M50
JR441_14090	COG0739	heme binding
JR441_14095	COG2894	cell division
JR441_14100	COG0850	regulation of cytokinetic process
JR441_14105	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JR441_14115	COG1077	Cell shape determining protein MreB Mrl
JR441_14120	COG2003	Belongs to the UPF0758 family
JR441_14125	COG0424	maF-like protein
JR441_14135	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JR441_14140	COG0285	dihydrofolate synthase activity
JR441_14145	COG0525	valine-tRNA ligase activity
JR441_14155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_14160	COG1388	LysM domain
JR441_14165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JR441_14170	COG0113	porphobilinogen synthase activity
JR441_14175	COG1587	Uroporphyrinogen-III synthase
JR441_14180	COG0181	hydroxymethylbilane synthase activity
JR441_14185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JR441_14190	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JR441_14200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JR441_14205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JR441_14210	COG0470	DNA polymerase III
JR441_14210	COG1067	ATP-dependent peptidase activity
JR441_14215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JR441_14220	COG0544	peptidyl-prolyl cis-trans isomerase activity
JR441_14225	COG0457	Tetratricopeptide repeat
JR441_14225	COG1477	protein flavinylation
JR441_14230	COG0066	3-isopropylmalate dehydratase activity
JR441_14235	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JR441_14240	COG0473	3-isopropylmalate dehydrogenase activity
JR441_14245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JR441_14250	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JR441_14255	COG0440	acetolactate synthase activity
JR441_14260	COG0028	Belongs to the TPP enzyme family
JR441_14270	COG0454	-acetyltransferase
JR441_14275	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
JR441_14285	COG0622	Phosphoesterase
JR441_14290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JR441_14295	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JR441_14300	COG5401	PFAM Sporulation and spore germination
JR441_14305	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JR441_14310	COG1846	Transcriptional regulator
JR441_14315	COG2197	response regulator
JR441_14320	COG0824	Thioesterase
JR441_14325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JR441_14330	COG1053	succinate dehydrogenase
JR441_14335	COG2009	succinate dehydrogenase
JR441_14340	COG1719	4-vinyl reductase, 4VR
JR441_14345	COG0527	aspartate kinase activity
JR441_14350	COG0322	excinuclease ABC activity
JR441_14355	COG3118	belongs to the thioredoxin family
JR441_14360	COG3534	alpha-L-arabinofuranosidase
JR441_14365	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
JR441_14370	COG2086	electron transfer activity
JR441_14375	COG1024	Enoyl-CoA hydratase
JR441_14380	COG1309	transcriptional regulator
JR441_14385	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_14390	COG3766	membrane
JR441_14395	COG1193	negative regulation of DNA recombination
JR441_14400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JR441_14400	COG1796	DNA polymerase
JR441_14405	COG1286	toxin biosynthetic process
JR441_14410	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JR441_14415	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JR441_14420	COG0072	phenylalanine-tRNA ligase activity
JR441_14420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_14425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JR441_14435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JR441_14445	COG3835	regulator
JR441_14450	COG0277	FAD linked oxidase domain protein
JR441_14455	COG0247	lactate metabolic process
JR441_14460	COG0346	lactoylglutathione lyase activity
JR441_14465	COG1966	Carbon starvation protein
JR441_14470	COG3534	alpha-L-arabinofuranosidase
JR441_14475	COG0395	ABC-type sugar transport system, permease component
JR441_14480	COG1175	transmembrane transport
JR441_14485	COG1653	transport
JR441_14490	COG0371	Dehydrogenase
JR441_14495	COG0647	UMP catabolic process
JR441_14500	COG0235	Class ii aldolase
JR441_14505	COG1069	ribulokinase activity
JR441_14510	COG2160	L-arabinose isomerase activity
JR441_14515	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_14520	COG1363	Peptidase, m42
JR441_14530	COG3326	Membrane
JR441_14535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JR441_14540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JR441_14545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JR441_14555	COG1346	cytolysis
JR441_14560	COG1380	Effector of murein hydrolase LrgA
JR441_14565	COG3279	Response regulator of the LytR AlgR family
JR441_14570	COG3275	phosphorelay sensor kinase activity
JR441_14575	COG1011	Hydrolase
JR441_14580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JR441_14590	COG0398	Pfam SNARE associated Golgi protein
JR441_14595	COG1484	DNA-dependent DNA replication
JR441_14600	COG3611	Membrane attachment protein
JR441_14605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JR441_14610	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JR441_14615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JR441_14620	COG1733	regulation of RNA biosynthetic process
JR441_14625	COG2814	Major facilitator Superfamily
JR441_14630	COG0656	L-ascorbic acid biosynthetic process
JR441_14635	COG0237	dephospho-CoA kinase activity
JR441_14640	COG1971	Probably functions as a manganese efflux pump
JR441_14645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JR441_14650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JR441_14650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JR441_14655	COG5002	protein histidine kinase activity
JR441_14660	COG0745	RESPONSE REGULATOR receiver
JR441_14665	COG0039	L-malate dehydrogenase activity
JR441_14670	COG0538	isocitrate dehydrogenase activity
JR441_14675	COG0372	Belongs to the citrate synthase family
JR441_14680	COG2707	UPF0756 membrane protein
JR441_14685	COG0628	permease
JR441_14690	COG3030	protein affecting phage T7 exclusion by the F plasmid
JR441_14695	COG0469	pyruvate kinase activity
JR441_14700	COG0205	6-phosphofructokinase activity
JR441_14705	COG0825	malonyl-CoA metabolic process
JR441_14710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JR441_14715	COG0281	malic enzyme
JR441_14720	COG0587	DNA-directed DNA polymerase activity
JR441_14740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JR441_14750	COG4109	DRTGG domain
JR441_14755	COG0730	response to heat
JR441_14760	COG1473	amidohydrolase
JR441_14765	COG0196	riboflavin kinase activity
JR441_14770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_14775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JR441_14780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_14785	COG1126	abc transporter atp-binding protein
JR441_14790	COG0765	amino acid transport
JR441_14795	COG0765	amino acid transport
JR441_14800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_14805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_14810	COG0454	-acetyltransferase
JR441_14815	COG0583	DNA-binding transcription factor activity
JR441_14820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JR441_14825	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_14830	COG0165	Argininosuccinate lyase
JR441_14835	COG0137	argininosuccinate synthase activity
JR441_14840	COG0521	Mo-molybdopterin cofactor biosynthetic process
JR441_14845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JR441_14855	COG0827	DNA restriction-modification system
JR441_14860	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JR441_14865	COG3874	Sporulation protein YtfJ
JR441_14875	COG1714	RDD family
JR441_14880	COG0616	signal peptide processing
JR441_14885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JR441_14890	COG1574	metal-dependent hydrolase with the TIM-barrel fold
JR441_14895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JR441_14905	COG0301	tRNA thio-modification
JR441_14910	COG1104	cysteine desulfurase activity
JR441_14915	COG1114	Component of the transport system for branched-chain amino acids
JR441_14920	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JR441_14925	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JR441_14930	COG1309	transcriptional regulator
JR441_14935	COG1956	GAF domain-containing protein
JR441_14940	COG2203	Gaf domain
JR441_14940	COG2199	diguanylate cyclase activity
JR441_14945	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JR441_14950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JR441_14955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JR441_14960	COG0454	-acetyltransferase
JR441_14965	COG0517	IMP dehydrogenase activity
JR441_14970	COG0123	including yeast histone deacetylase and acetoin utilization protein
JR441_14975	COG1360	Flagellar Motor Protein
JR441_14980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JR441_14985	COG1609	Transcriptional regulator
JR441_14990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JR441_14990	COG1605	Chorismate mutase
JR441_14995	COG3118	belongs to the thioredoxin family
JR441_15000	COG4980	gas vesicle protein
JR441_15005	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JR441_15010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JR441_15015	COG1674	ftsk spoiiie
JR441_15020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JR441_15025	COG4848	Belongs to the UPF0354 family
JR441_15030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_15045	COG1363	Peptidase, m42
JR441_15050	COG5584	Small secreted protein
JR441_15055	COG0281	malic enzyme
JR441_15060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_15065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JR441_15075	COG0510	thiamine kinase activity
JR441_15080	COG1523	belongs to the glycosyl hydrolase 13 family
JR441_15085	COG1597	lipid kinase activity
JR441_15095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JR441_15100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JR441_15105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_15110	COG2252	PERMEase
JR441_15115	COG4473	ABC transporter
JR441_15120	COG1131	(ABC) transporter
JR441_15125	COG1349	DNA-binding transcription factor activity
JR441_15130	COG1187	pseudouridine synthase activity
JR441_15135	COG2244	polysaccharide biosynthetic process
JR441_15140	COG2081	HI0933 family
JR441_15145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JR441_15155	COG5578	integral membrane protein
JR441_15160	COG0673	inositol 2-dehydrogenase activity
JR441_15165	COG1653	transport
JR441_15170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JR441_15175	COG4209	transmembrane transport
JR441_15180	COG2207	Transcriptional regulator
JR441_15185	COG1653	transport
JR441_15190	COG0395	ABC-type sugar transport system, permease component
JR441_15195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_15200	COG2124	cytochrome p450
JR441_15205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JR441_15215	COG0156	8-amino-7-oxononanoate synthase activity
JR441_15220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JR441_15230	COG1073	alpha beta
JR441_15235	COG1609	Transcriptional regulator
JR441_15240	COG1653	transport
JR441_15245	COG1175	transmembrane transport
JR441_15250	COG0395	ABC-type sugar transport system, permease component
JR441_15255	COG1486	melibiose metabolic process
JR441_15260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JR441_15265	COG0495	leucyl-tRNA aminoacylation
JR441_15275	COG2202	Pas domain
JR441_15275	COG1366	Belongs to the anti-sigma-factor antagonist family
JR441_15280	COG2814	Major facilitator Superfamily
JR441_15285	COG2433	Pfam Transposase IS66
JR441_15290	COG0577	efflux transmembrane transporter activity
JR441_15295	COG1136	(ABC) transporter
JR441_15300	COG2205	protein histidine kinase activity
JR441_15305	COG0745	RESPONSE REGULATOR receiver
JR441_15310	COG0577	efflux transmembrane transporter activity
JR441_15315	COG1136	(ABC) transporter
JR441_15330	COG1131	(ABC) transporter
JR441_15335	COG1725	Transcriptional regulator
JR441_15350	COG1242	4 iron, 4 sulfur cluster binding
JR441_15355	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JR441_15365	COG2267	carboxylic ester hydrolase activity
JR441_15370	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JR441_15375	COG1113	amino acid transport
JR441_15380	COG0367	asparagine synthase
JR441_15385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JR441_15390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JR441_15400	COG1506	peptidase
JR441_15405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JR441_15410	COG1116	anion transmembrane transporter activity
JR441_15415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JR441_15420	COG0494	nUDIX hydrolase
JR441_15425	COG4824	toxin secretion phage lysis holin
JR441_15430	COG0783	Belongs to the Dps family
JR441_15445	COG1854	S-ribosylhomocysteine lyase activity
JR441_15450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JR441_15455	COG0288	reversible hydration of carbon dioxide
JR441_15460	COG0254	rRNA binding
JR441_15465	COG1271	oxidase subunit
JR441_15470	COG1294	oxidase, subunit
JR441_15480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR441_15485	COG1321	iron dependent repressor
JR441_15485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JR441_15490	COG1121	(ABC) transporter
JR441_15495	COG0803	Belongs to the bacterial solute-binding protein 9 family
JR441_15500	COG4948	Mandelate Racemase Muconate Lactonizing
JR441_15505	COG0318	PFAM AMP-dependent synthetase and ligase
JR441_15510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JR441_15515	COG0596	Alpha beta hydrolase
JR441_15520	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JR441_15525	COG1169	isochorismate synthase
JR441_15530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JR441_15535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JR441_15540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JR441_15545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_15550	COG0438	transferase activity, transferring glycosyl groups
JR441_15560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_15565	COG0438	transferase activity, transferring glycosyl groups
JR441_15570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_15575	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
JR441_15580	COG0058	SHG alpha-glucan phosphorylase activity
JR441_15585	COG0297	glycogen (starch) synthase activity
JR441_15590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JR441_15595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JR441_15600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JR441_15725	COG3859	Proton-coupled thiamine transporter YuaJ
JR441_15730	COG1247	-acetyltransferase
JR441_15735	COG2268	Band 7 protein
JR441_15740	COG1585	Membrane protein implicated in regulation of membrane protease activity
JR441_15745	COG2318	DinB family
JR441_15755	COG1454	alcohol dehydrogenase
JR441_15760	COG1012	belongs to the aldehyde dehydrogenase family
JR441_15765	COG1510	regulation of RNA biosynthetic process
JR441_15775	COG0569	domain protein
JR441_15780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JR441_15785	COG4682	membrane
JR441_15790	COG1705	Flagellar rod assembly protein muramidase FlgJ
JR441_15795	COG0477	Major facilitator Superfamily
JR441_15800	COG5553	Cysteine dioxygenase type I
JR441_15810	COG1968	undecaprenyl-diphosphatase activity
JR441_15815	COG0628	permease
JR441_15820	COG0673	inositol 2-dehydrogenase activity
JR441_15825	COG4806	L-rhamnose isomerase
JR441_15830	COG3254	rhamnose metabolic process
JR441_15835	COG1070	Carbohydrate kinase
JR441_15840	COG1349	DNA-binding transcription factor activity
JR441_15845	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_15845	COG3347	Dehydrogenase
JR441_15850	COG0840	transmembrane signaling receptor activity
JR441_15855	COG0840	transmembrane signaling receptor activity
JR441_15860	COG0840	transmembrane signaling receptor activity
JR441_15865	COG0840	transmembrane signaling receptor activity
JR441_15880	COG0432	Pfam Uncharacterised protein family UPF0047
JR441_15890	COG0366	Alpha amylase catalytic
JR441_15895	COG1253	flavin adenine dinucleotide binding
JR441_15900	COG2738	Putative neutral zinc metallopeptidase
JR441_15915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JR441_15930	COG0166	Belongs to the GPI family
JR441_15935	COG1979	alcohol dehydrogenase
JR441_15940	COG1979	alcohol dehydrogenase
JR441_15945	COG2155	Conserved Protein
JR441_15950	COG1098	S1 RNA binding domain
JR441_15955	COG0436	Aminotransferase
JR441_15960	COG1522	sequence-specific DNA binding
JR441_15965	COG2267	carboxylic ester hydrolase activity
JR441_15975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JR441_15980	COG2205	protein histidine kinase activity
JR441_15990	COG5018	Exonuclease
JR441_15995	COG2814	Major facilitator Superfamily
JR441_16000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_16005	COG3011	Protein conserved in bacteria
JR441_16015	COG3290	protein histidine kinase activity
JR441_16020	COG4565	transcriptional regulatory protein
JR441_16025	COG1744	ABC transporter substrate-binding protein PnrA-like
JR441_16030	COG3845	ABC transporter
JR441_16035	COG4603	Belongs to the binding-protein-dependent transport system permease family
JR441_16040	COG1079	Belongs to the binding-protein-dependent transport system permease family
JR441_16045	COG3493	citrate carrier protein
JR441_16055	COG2111	Na H antiporter
JR441_16055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JR441_16060	COG2111	Na H antiporter
JR441_16065	COG1006	Multisubunit Na H antiporter MnhC subunit
JR441_16070	COG0651	ATP synthesis coupled electron transport
JR441_16075	COG1863	multisubunit Na H antiporter MnhE subunit
JR441_16080	COG2212	antiporter activity
JR441_16085	COG1320	monovalent cation:proton antiporter activity
JR441_16090	COG2050	protein possibly involved in aromatic compounds catabolism
JR441_16095	COG2197	response regulator
JR441_16110	COG0142	geranyltranstransferase activity
JR441_16130	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JR441_16135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JR441_16140	COG1335	isochorismatase
JR441_16145	COG5506	Protein of unknown function (DUF1694)
JR441_16160	COG0628	permease
JR441_16175	COG1418	mRNA catabolic process
JR441_16180	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_16190	COG1511	domain protein
JR441_16195	COG0433	COG0433 Predicted ATPase
JR441_16195	COG1674	ftsk spoiiie
JR441_16200	COG4499	WXG100 protein secretion system (Wss), protein YukC
JR441_16205	COG5417	Belongs to the EsaB family
JR441_16210	COG4842	Belongs to the WXG100 family
JR441_16215	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JR441_16215	COG2508	Transcriptional regulator
JR441_16220	COG0686	Belongs to the AlaDH PNT family
JR441_16225	COG5634	Uncharacterized conserved protein (DUF2278)
JR441_16230	COG3251	PFAM MbtH domain protein
JR441_16235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_16240	COG1535	isochorismatase
JR441_16240	COG3433	isochorismatase activity
JR441_16245	COG1021	2,3-dihydroxybenzoate-AMP ligase
JR441_16250	COG1169	isochorismate synthase
JR441_16255	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_16260	COG2819	hydrolase of the alpha beta superfamily
JR441_16265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JR441_16270	COG1268	BioY protein
JR441_16275	COG2056	Na+-H+ antiporter family
JR441_16280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JR441_16285	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
JR441_16290	COG3584	3D domain protein
JR441_16305	COG1252	NADH dehydrogenase
JR441_16310	COG0492	ferredoxin-NADP+ reductase activity
JR441_16320	COG0516	GMP reductase activity
JR441_16325	COG2808	Putative FMN-binding domain
JR441_16330	COG0456	acetyltransferase
JR441_16335	COG0316	Belongs to the HesB IscA family
JR441_16340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JR441_16345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JR441_16350	COG4844	belongs to the
JR441_16355	COG1252	NADH dehydrogenase
JR441_16360	COG4837	Protein of unknown function (DUF1462)
JR441_16365	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JR441_16370	COG0823	Involved in the tonB-independent uptake of proteins
JR441_16370	COG4946	Tricorn protease homolog
JR441_16370	COG1506	peptidase
JR441_16375	COG0083	homoserine kinase activity
JR441_16380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JR441_16385	COG0460	homoserine dehydrogenase
JR441_16390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JR441_16395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JR441_16400	COG0647	UMP catabolic process
JR441_16405	COG2445	Protein of unknown function DUF86
JR441_16410	COG4470	Protein conserved in bacteria
JR441_16420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JR441_16425	COG0739	heme binding
JR441_16435	COG3377	Domain of unknown function (DUF1805)
JR441_16440	COG0737	Belongs to the 5'-nucleotidase family
JR441_16445	COG0730	response to heat
JR441_16450	COG1801	Protein of unknown function DUF72
JR441_16460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JR441_16465	COG2508	Transcriptional regulator
JR441_16470	COG2233	PERMEase
JR441_16475	COG2233	PERMEase
JR441_16480	COG3648	Uricase
JR441_16480	COG3195	allantoin biosynthetic process
JR441_16485	COG2351	hydroxyisourate hydrolase activity
JR441_16495	COG2080	2 iron, 2 sulfur cluster binding
JR441_16500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JR441_16505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
JR441_16510	COG2068	MobA-Related Protein
JR441_16515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
JR441_16520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JR441_16525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JR441_16535	COG2356	endonuclease I
JR441_16540	COG3842	ATPase activity
JR441_16545	COG2188	Transcriptional regulator
JR441_16550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_16555	COG0395	ABC-type sugar transport system, permease component
JR441_16560	COG1175	transmembrane transport
JR441_16565	COG1653	transport
JR441_16570	COG2222	sugar isomerase
JR441_16575	COG0322	excinuclease ABC activity
JR441_16580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JR441_16595	COG0346	lactoylglutathione lyase activity
JR441_16600	COG0640	Transcriptional regulator
JR441_16605	COG0719	Fe-S assembly protein
JR441_16610	COG0822	iron-sulfur transferase activity
JR441_16615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JR441_16620	COG0719	Fe-S assembly protein
JR441_16625	COG0396	ATPase activity
JR441_16635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JR441_16640	COG1464	Belongs to the NlpA lipoprotein family
JR441_16645	COG2011	ABC-type metal ion transport system permease component
JR441_16650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JR441_16660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JR441_16665	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JR441_16675	COG0509	glycine decarboxylation via glycine cleavage system
JR441_16680	COG1393	Belongs to the ArsC family
JR441_16685	COG1960	acyl-CoA dehydrogenase activity
JR441_16690	COG0183	Belongs to the thiolase family
JR441_16695	COG1024	Enoyl-CoA hydratase
JR441_16695	COG1250	3-hydroxyacyl-CoA dehydrogenase
JR441_16705	COG0506	proline dehydrogenase activity
JR441_16715	COG5577	PFAM Coat F domain
JR441_16720	COG1846	Transcriptional regulator
JR441_16725	COG0477	Major facilitator Superfamily
JR441_16730	COG1942	4-Oxalocrotonate Tautomerase
JR441_16735	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_16740	COG0583	DNA-binding transcription factor activity
JR441_16750	COG1120	ATPase activity
JR441_16765	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_16770	COG0783	Belongs to the Dps family
JR441_16775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_16780	COG0745	RESPONSE REGULATOR receiver
JR441_16785	COG2205	protein histidine kinase activity
JR441_16785	COG2770	Histidine kinase
JR441_16795	COG1309	transcriptional regulator
JR441_16800	COG0114	fumarate hydratase activity
JR441_16810	COG0697	spore germination
JR441_16815	COG0814	amino acid
JR441_16825	COG2197	response regulator
JR441_16830	COG4585	Histidine kinase
JR441_16835	COG4758	membrane
JR441_16840	COG3595	metallopeptidase activity
JR441_16845	COG1842	Phage shock protein A
JR441_16850	COG4758	membrane
JR441_16855	COG2814	Major facilitator Superfamily
JR441_16860	COG2096	Adenosyltransferase
JR441_16865	COG1120	ATPase activity
JR441_16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_16875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_16880	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_16885	COG3386	PFAM SMP-30 Gluconolaconase
JR441_16890	COG2205	protein histidine kinase activity
JR441_16895	COG0745	RESPONSE REGULATOR receiver
JR441_16905	COG1191	sigma factor activity
JR441_16915	COG2140	Oxalate decarboxylase
JR441_16925	COG0577	efflux transmembrane transporter activity
JR441_16930	COG1136	(ABC) transporter
JR441_16935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JR441_16940	COG1120	ATPase activity
JR441_16945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_16950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JR441_16955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_16960	COG0531	amino acid
JR441_16970	COG1988	membrane-bound metal-dependent
JR441_16975	COG1368	sulfuric ester hydrolase activity
JR441_16980	COG1910	domain protein
JR441_16985	COG0725	ABC transporter, periplasmic molybdate-binding protein
JR441_16990	COG4149	molybdate abc transporter
JR441_16995	COG0656	L-ascorbic acid biosynthetic process
JR441_17005	COG0025	NhaP-type Na H and K H
JR441_17010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JR441_17015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JR441_17020	COG3973	AAA domain
JR441_17030	COG2860	membrane
JR441_17035	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JR441_17040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JR441_17045	COG2217	Heavy metal translocating P-type atpase
JR441_17050	COG2217	Heavy metal translocating P-type atpase
JR441_17055	COG2608	mercury ion transmembrane transporter activity
JR441_17060	COG1937	Protein conserved in bacteria
JR441_17065	COG0673	inositol 2-dehydrogenase activity
JR441_17070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JR441_17075	COG1289	transmembrane transporter activity
JR441_17085	COG2076	Multidrug Resistance protein
JR441_17090	COG1309	transcriptional regulator
JR441_17095	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_17105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JR441_17110	COG0557	exoribonuclease II activity
JR441_17115	COG1647	Serine aminopeptidase, S33
JR441_17120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JR441_17125	COG0596	Alpha beta hydrolase
JR441_17130	COG1476	TRANSCRIPTIONal
JR441_17135	COG1396	sequence-specific DNA binding
JR441_17140	COG1396	sequence-specific DNA binding
JR441_17145	COG1733	regulation of RNA biosynthetic process
JR441_17150	COG0840	transmembrane signaling receptor activity
JR441_17155	COG1174	glycine betaine transport
JR441_17160	COG1732	Glycine betaine
JR441_17165	COG1174	glycine betaine transport
JR441_17170	COG0517	IMP dehydrogenase activity
JR441_17170	COG1125	glycine betaine transport
JR441_17175	COG1510	regulation of RNA biosynthetic process
JR441_17180	COG1174	glycine betaine transport
JR441_17185	COG1732	Glycine betaine
JR441_17190	COG1174	glycine betaine transport
JR441_17195	COG0517	IMP dehydrogenase activity
JR441_17195	COG1125	glycine betaine transport
JR441_17200	COG1510	regulation of RNA biosynthetic process
JR441_17205	COG2095	MarC family integral membrane protein
JR441_17215	COG3064	Membrane
JR441_17220	COG4640	response to antibiotic
JR441_17225	COG0456	acetyltransferase
JR441_17240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JR441_17255	COG0436	Aminotransferase
JR441_17260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JR441_17265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_17275	COG2234	aminopeptidase activity
JR441_17280	COG0148	phosphopyruvate hydratase activity
JR441_17285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JR441_17290	COG0149	triose-phosphate isomerase activity
JR441_17295	COG0126	phosphoglycerate kinase activity
JR441_17300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JR441_17305	COG2390	Transcriptional regulator
JR441_17310	COG2814	Major facilitator Superfamily
JR441_17315	COG1609	Transcriptional regulator
JR441_17320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_17325	COG0583	DNA-binding transcription factor activity
JR441_17330	COG0697	spore germination
JR441_17335	COG1113	amino acid transport
JR441_17340	COG3858	chitin binding
JR441_17345	COG1556	Lactate utilization protein
JR441_17350	COG1139	Iron-sulfur cluster binding protein
JR441_17355	COG0247	lactate metabolic process
JR441_17360	COG2197	response regulator
JR441_17365	COG4585	Histidine kinase
JR441_17370	COG0842	Transport permease protein
JR441_17375	COG1131	(ABC) transporter
JR441_17380	COG0596	Alpha beta hydrolase
JR441_17385	COG2208	phosphoserine phosphatase activity
JR441_17390	COG3867	Arabinogalactan endo-beta-1,4-galactanase
JR441_17395	COG1874	Beta-galactosidase
JR441_17400	COG3833	ABC-type maltose transport systems, permease component
JR441_17410	COG2182	Extracellular solute-binding protein
JR441_17415	COG1609	Transcriptional regulator
JR441_17420	COG2186	Transcriptional regulator
JR441_17425	COG1620	l-lactate permease
JR441_17430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JR441_17440	COG5039	Polysaccharide pyruvyl transferase
JR441_17445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_17450	COG0110	maltose O-acetyltransferase activity
JR441_17455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JR441_17460	COG2244	polysaccharide biosynthetic process
JR441_17465	COG1216	Glycosyl transferase, family 2
JR441_17470	COG5039	Polysaccharide pyruvyl transferase
JR441_17475	COG1216	Glycosyl transferase, family 2
JR441_17485	COG0438	transferase activity, transferring glycosyl groups
JR441_17490	COG1215	transferase activity, transferring glycosyl groups
JR441_17495	COG0438	transferase activity, transferring glycosyl groups
JR441_17500	COG1086	Polysaccharide biosynthesis protein
JR441_17505	COG0489	protein tyrosine kinase activity
JR441_17510	COG3944	biosynthesis protein
JR441_17515	COG1396	sequence-specific DNA binding
JR441_17520	COG2272	Belongs to the type-B carboxylesterase lipase family
JR441_17530	COG3479	Phenolic acid decarboxylase
JR441_17540	COG1794	racemase activity, acting on amino acids and derivatives
JR441_17550	COG1621	beta-fructofuranosidase activity
JR441_17555	COG1621	beta-fructofuranosidase activity
JR441_17560	COG0531	amino acid
JR441_17565	COG1309	transcriptional regulator
JR441_17570	COG2076	Multidrug Resistance protein
JR441_17575	COG2076	Multidrug Resistance protein
JR441_17585	COG0277	FAD linked oxidase domain protein
JR441_17590	COG3621	Patatin-like phospholipase
JR441_17630	COG0740	serine-type endopeptidase activity
JR441_17635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JR441_17640	COG0366	Alpha amylase catalytic
JR441_17645	COG1554	hydrolase, family 65, central catalytic
JR441_17650	COG5521	maltodextrose utilization protein MalA
JR441_17655	COG3833	ABC-type maltose transport systems, permease component
JR441_17660	COG1175	transmembrane transport
JR441_17665	COG2182	Extracellular solute-binding protein
JR441_17670	COG0366	Alpha amylase catalytic
JR441_17675	COG1609	Transcriptional regulator
JR441_17680	COG1611	Belongs to the LOG family
JR441_17685	COG1694	Mazg nucleotide pyrophosphohydrolase
JR441_17690	COG0659	secondary active sulfate transmembrane transporter activity
JR441_17695	COG0288	reversible hydration of carbon dioxide
JR441_17700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JR441_17705	COG0577	efflux transmembrane transporter activity
JR441_17710	COG1136	(ABC) transporter
JR441_17715	COG5002	protein histidine kinase activity
JR441_17720	COG0745	RESPONSE REGULATOR receiver
JR441_17730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JR441_17735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_17740	COG1481	regulation of sporulation
JR441_17745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JR441_17750	COG1660	Displays ATPase and GTPase activities
JR441_17755	COG1051	belongs to the nudix hydrolase family
JR441_17760	COG0492	ferredoxin-NADP+ reductase activity
JR441_17765	COG3883	PFAM NLP P60 protein
JR441_17765	COG0791	NLP P60 protein
JR441_17770	COG0457	Tetratricopeptide repeat
JR441_17775	COG1132	(ABC) transporter
JR441_17795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JR441_17795	COG0140	phosphoribosyl-ATP diphosphatase activity
JR441_17800	COG0107	imidazoleglycerol-phosphate synthase activity
JR441_17805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JR441_17810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JR441_17815	COG0131	Imidazoleglycerol-phosphate dehydratase
JR441_17820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JR441_17825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JR441_17830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JR441_17835	COG4990	cell redox homeostasis
JR441_17840	COG5297	Belongs to the glycosyl hydrolase family 6
JR441_17845	COG0110	maltose O-acetyltransferase activity
JR441_17850	COG0546	phosphoglycolate phosphatase activity
JR441_17855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JR441_17860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JR441_17865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JR441_17870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JR441_17875	COG0363	glucosamine-6-phosphate deaminase activity
JR441_17880	COG2188	Transcriptional regulator
JR441_17885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JR441_17890	COG1950	PFAM Membrane protein of
JR441_17895	COG1983	PspC domain protein
JR441_17900	COG3595	metallopeptidase activity
JR441_17915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JR441_17920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JR441_17925	COG0556	nucleotide-excision repair
JR441_17930	COG4897	Protein conserved in bacteria
JR441_17935	COG0574	Belongs to the PEP-utilizing enzyme family
JR441_17935	COG3848	Pyruvate phosphate dikinase
JR441_17940	COG1309	transcriptional regulator
JR441_17945	COG2814	Major facilitator Superfamily
JR441_17950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_17960	COG3409	Peptidoglycan-binding domain 1 protein
JR441_17960	COG0793	Belongs to the peptidase S41A family
JR441_17965	COG2177	Part of the ABC transporter FtsEX involved in
JR441_17970	COG2884	Cell division ATP-binding protein ftsE
JR441_17975	COG2010	Cytochrome c
JR441_17980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_17990	COG0653	protein targeting
JR441_17995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JR441_18010	COG1516	flagellar protein fliS
JR441_18015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JR441_18020	COG1334	flagellar protein FlaG
JR441_18025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JR441_18030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JR441_18035	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
JR441_18045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JR441_18050	COG4786	Flagellar basal body rod
JR441_18050	COG1256	bacterial-type flagellum assembly
JR441_18055	COG3418	PFAM FlgN family protein
JR441_18060	COG2747	anti-sigma28 factor FlgM
JR441_18070	COG1040	competence protein
JR441_18080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JR441_18085	COG1307	EDD domain protein, DegV family
JR441_18090	COG2197	response regulator
JR441_18095	COG4585	Histidine kinase
JR441_18100	COG1739	Uncharacterized protein family UPF0029
JR441_18105	COG1316	TRANSCRIPTIONal
JR441_18110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JR441_18115	COG0438	transferase activity, transferring glycosyl groups
JR441_18120	COG1215	transferase activity, transferring glycosyl groups
JR441_18125	COG3206	protein involved in exopolysaccharide biosynthesis
JR441_18130	COG3307	-O-antigen
JR441_18135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JR441_18140	COG0438	transferase activity, transferring glycosyl groups
JR441_18140	COG0297	glycogen (starch) synthase activity
JR441_18145	COG2244	polysaccharide biosynthetic process
JR441_18160	COG0860	N-Acetylmuramoyl-L-alanine amidase
JR441_18160	COG2247	cell wall binding repeat
JR441_18165	COG2247	cell wall binding repeat
JR441_18165	COG2385	sporulation resulting in formation of a cellular spore
JR441_18175	COG1316	TRANSCRIPTIONal
JR441_18180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JR441_18200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JR441_18205	COG1134	teichoic acid transport
JR441_18210	COG1682	transport, permease protein
JR441_18215	COG1215	transferase activity, transferring glycosyl groups
JR441_18215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JR441_18220	COG0463	Glycosyl transferase, family 2
JR441_18265	COG4193	domain, Protein
JR441_18270	COG1482	cell wall glycoprotein biosynthetic process
JR441_18275	COG0697	spore germination
JR441_18280	COG0814	amino acid
JR441_18290	COG2814	Major facilitator Superfamily
JR441_18295	COG1316	TRANSCRIPTIONal
JR441_18300	COG0561	phosphatase activity
JR441_18305	COG0791	NLP P60 protein
JR441_18315	COG2843	Capsule synthesis protein
JR441_18325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JR441_18330	COG1609	Transcriptional regulator
JR441_18335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_18340	COG1869	D-ribose catabolic process
JR441_18345	COG1129	ABC transporter
JR441_18350	COG1172	Belongs to the binding-protein-dependent transport system permease family
JR441_18355	COG1879	ABC-type sugar transport system periplasmic component
JR441_18360	COG3103	Sh3 type 3 domain protein
JR441_18370	COG2249	NAD(P)H dehydrogenase (quinone) activity
JR441_18375	COG3527	Alpha-acetolactate decarboxylase
JR441_18380	COG0028	Belongs to the TPP enzyme family
JR441_18385	COG0583	DNA-binding transcription factor activity
JR441_18390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JR441_18405	COG5337	Spore coat protein CotH
JR441_18415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JR441_18425	COG0405	Gamma-glutamyltransferase
JR441_18430	COG1522	sequence-specific DNA binding
JR441_18435	COG2059	Chromate
JR441_18440	COG2059	Chromate
JR441_18450	COG0655	NAD(P)H dehydrogenase (quinone) activity
JR441_18455	COG0583	DNA-binding transcription factor activity
JR441_18460	COG1515	deoxyribonuclease V activity
JR441_18475	COG5444	nuclease activity
JR441_18490	COG3878	Protein conserved in bacteria
JR441_18495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
JR441_18500	COG4464	protein tyrosine phosphatase activity
JR441_18505	COG0489	protein tyrosine kinase activity
JR441_18510	COG3944	biosynthesis protein
JR441_18520	COG4715	Zinc finger, swim domain protein
JR441_18525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JR441_18530	COG0561	phosphatase activity
JR441_18535	COG1349	DNA-binding transcription factor activity
JR441_18540	COG0629	single-stranded DNA binding
JR441_18555	COG3764	Sortase (surface protein transpeptidase)
JR441_18560	COG2972	Histidine kinase
JR441_18560	COG0745	RESPONSE REGULATOR receiver
JR441_18565	COG1970	mechanosensitive ion channel activity
JR441_18570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JR441_18575	COG0457	Tetratricopeptide repeat
JR441_18580	COG4786	Flagellar basal body rod
JR441_18585	COG4786	Flagellar basal body rod
JR441_18590	COG1077	Cell shape determining protein MreB Mrl
JR441_18595	COG1609	Transcriptional regulator
JR441_18605	COG1846	Transcriptional regulator
JR441_18610	COG2814	Major facilitator Superfamily
JR441_18615	COG3420	alginic acid biosynthetic process
JR441_18620	COG1953	Uracil, thiamine, allantoin
JR441_18625	COG0477	Major facilitator Superfamily
JR441_18630	COG1335	isochorismatase
JR441_18640	COG0004	ammonium transporteR
JR441_18645	COG0347	Belongs to the P(II) protein family
JR441_18650	COG0671	phosphoesterase, PA-phosphatase related
JR441_18660	COG0739	heme binding
JR441_18665	COG1247	-acetyltransferase
JR441_18685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JR441_18690	COG0789	Transcriptional regulator
JR441_18700	COG2910	NAD(P)H-binding
JR441_18705	COG1959	2 iron, 2 sulfur cluster binding
JR441_18710	COG0804	urea catabolic process
JR441_18715	COG0832	Belongs to the urease beta subunit family
JR441_18720	COG0831	urea catabolic process
JR441_18735	COG3237	CsbD-like
JR441_18740	COG1994	Peptidase M50
JR441_18745	COG0457	Tetratricopeptide repeat
JR441_18750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JR441_18755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JR441_18765	COG2304	oxidoreductase activity
JR441_18775	COG2304	oxidoreductase activity
JR441_18780	COG2385	sporulation resulting in formation of a cellular spore
JR441_18785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JR441_18795	COG4836	Membrane
JR441_18805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JR441_18810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JR441_18815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JR441_18820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JR441_18825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JR441_18830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JR441_18840	COG0356	it plays a direct role in the translocation of protons across the membrane
JR441_18850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JR441_18855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JR441_18860	COG4475	Protein of unknown function (DUF436)
JR441_18865	COG0698	ribose 5-phosphate isomerase
JR441_18870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JR441_18875	COG1971	Probably functions as a manganese efflux pump
JR441_18880	COG0009	L-threonylcarbamoyladenylate synthase
JR441_18885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JR441_18905	COG2890	protein-(glutamine-N5) methyltransferase activity
JR441_18910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JR441_18915	COG0346	lactoylglutathione lyase activity
JR441_18920	COG0789	Transcriptional regulator
JR441_18925	COG0679	Auxin Efflux Carrier
JR441_18930	COG0281	malic enzyme
JR441_18935	COG1435	thymidine kinase activity
JR441_18945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JR441_18955	COG1494	fructose-1,6-bisphosphatase
JR441_18960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JR441_18965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JR441_18970	COG0191	fructose-bisphosphate aldolase activity
JR441_18975	COG2204	response regulator
JR441_18980	COG4821	SIS domain
JR441_18985	COG0504	CTP synthase activity
JR441_18990	COG3343	RNA polymerase activity
JR441_18995	COG1960	acyl-CoA dehydrogenase activity
JR441_19000	COG2181	nitrate reductase activity
JR441_19000	COG0247	lactate metabolic process
JR441_19005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JR441_19010	COG4294	response to UV
JR441_19025	COG1132	(ABC) transporter
JR441_19030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JR441_19035	COG2181	nitrate reductase activity
JR441_19040	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
JR441_19045	COG1140	nitrate reductase beta subunit
JR441_19050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JR441_19055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JR441_19065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JR441_19070	COG2223	nitrite transmembrane transporter activity
JR441_19075	COG0018	arginyl-trna synthetase
JR441_19080	COG4506	Protein conserved in bacteria
JR441_19095	COG0535	radical SAM domain protein
JR441_19105	COG1131	(ABC) transporter
JR441_19110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JR441_19115	COG0612	Peptidase, M16
JR441_19120	COG0612	Peptidase, M16
JR441_19130	COG3391	amine dehydrogenase activity
JR441_19135	COG3391	amine dehydrogenase activity
JR441_19140	COG0457	Tetratricopeptide repeat
JR441_19155	COG0010	Belongs to the arginase family
JR441_19160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JR441_19165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JR441_19175	COG1994	Peptidase M50
JR441_19180	COG1942	4-Oxalocrotonate Tautomerase
JR441_19185	COG1846	Transcriptional regulator
JR441_19190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JR441_19195	COG0477	Major facilitator Superfamily
JR441_19200	COG1959	2 iron, 2 sulfur cluster binding
JR441_19205	COG3465	dGTPase activity
JR441_19210	COG1078	dGTPase activity
JR441_19215	COG4844	belongs to the
JR441_19225	COG0697	spore germination
JR441_19230	COG0095	Lipoate-protein ligase
JR441_19235	COG0583	DNA-binding transcription factor activity
JR441_19240	COG0280	phosphate acetyltransferase
JR441_19245	COG3253	May function as heme-dependent peroxidase
JR441_19250	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_19255	COG0436	Aminotransferase
JR441_19260	COG2814	Major facilitator Superfamily
JR441_19265	COG0151	Belongs to the GarS family
JR441_19270	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_19275	COG1917	Cupin 2, conserved barrel domain protein
JR441_19280	COG0077	Prephenate dehydratase
JR441_19285	COG2814	Major facilitator Superfamily
JR441_19290	COG0833	amino acid
JR441_19295	COG4187	Peptidase family M20/M25/M40
JR441_19300	COG1012	belongs to the aldehyde dehydrogenase family
JR441_19305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JR441_19315	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
JR441_19320	COG1091	dTDP-4-dehydrorhamnose reductase activity
JR441_19325	COG1088	dTDP-glucose 4,6-dehydratase activity
JR441_19330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JR441_19335	COG3980	spore coat polysaccharide biosynthesis protein
JR441_19340	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
JR441_19345	COG2089	acid synthase
JR441_19350	COG0456	acetyltransferase
JR441_19355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JR441_19360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JR441_19365	COG0463	Glycosyl transferase, family 2
JR441_19375	COG2363	Small membrane protein
JR441_19380	COG2233	PERMEase
JR441_19390	COG1012	belongs to the aldehyde dehydrogenase family
JR441_19395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JR441_19400	COG1216	Glycosyl transferase, family 2
JR441_19405	COG0351	phosphomethylpyrimidine kinase
JR441_19415	COG1621	beta-fructofuranosidase activity
JR441_19420	COG1263	PTS System
JR441_19420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_19425	COG2116	formate transmembrane transporter activity
JR441_19430	COG3711	transcriptional antiterminator
JR441_19440	COG1404	Belongs to the peptidase S8 family
JR441_19445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_19450	COG0778	Nitroreductase
JR441_19455	COG0772	Belongs to the SEDS family
JR441_19465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JR441_19470	COG1845	cytochrome c oxidase, subunit III
JR441_19475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JR441_19480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JR441_19485	COG2261	transglycosylase associated protein
JR441_19490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JR441_19495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JR441_19500	COG2246	polysaccharide biosynthetic process
JR441_19505	COG1309	transcriptional regulator
JR441_19515	COG3162	membrane
JR441_19520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JR441_19525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JR441_19530	COG2837	iron assimilation
JR441_19535	COG2822	iron ion transport
JR441_19540	COG0672	)-iron permease
JR441_19545	COG0352	thiamine-phosphate diphosphorylase activity
JR441_19550	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JR441_19555	COG0583	DNA-binding transcription factor activity
JR441_19560	COG1380	Effector of murein hydrolase LrgA
JR441_19565	COG1346	cytolysis
JR441_19570	COG2814	Major facilitator Superfamily
JR441_19575	COG4895	conserved protein (DUF2196)
JR441_19580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JR441_19585	COG0346	lactoylglutathione lyase activity
JR441_19595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_19600	COG1404	Belongs to the peptidase S8 family
JR441_19605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_19605	COG1263	PTS System
JR441_19610	COG3711	transcriptional antiterminator
JR441_19615	COG1442	glycosyl transferase family 8
JR441_19620	COG5522	Integral membrane protein (intg_mem_TP0381)
JR441_19625	COG1846	Transcriptional regulator
JR441_19630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JR441_19635	COG2234	aminopeptidase activity
JR441_19640	COG2357	RelA SpoT domain protein
JR441_19645	COG1575	Belongs to the MenA family. Type 1 subfamily
JR441_19660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JR441_19665	COG1696	Membrane protein involved in D-alanine export
JR441_19670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JR441_19675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JR441_19680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
JR441_19685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JR441_19690	COG1486	melibiose metabolic process
JR441_19695	COG1447	Phosphotransferase system cellobiose-specific component IIA
JR441_19700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_19705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JR441_19710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JR441_19710	COG3711	transcriptional antiterminator
JR441_19720	COG2094	Belongs to the DNA glycosylase MPG family
JR441_19725	COG0753	catalase activity
JR441_19730	COG2814	Major facilitator Superfamily
JR441_19735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JR441_19740	COG1131	(ABC) transporter
JR441_19760	COG1595	DNA-templated transcription, initiation
JR441_19765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JR441_19770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JR441_19775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JR441_19780	COG4988	ABC transporter
JR441_19785	COG1294	oxidase, subunit
JR441_19790	COG1271	oxidase subunit
JR441_19795	COG3493	citrate carrier protein
JR441_19800	COG0501	Belongs to the peptidase M48B family
JR441_19810	COG0726	polysaccharide deacetylase
JR441_19815	COG3842	ATPase activity
JR441_19820	COG2508	Transcriptional regulator
JR441_19825	COG1012	belongs to the aldehyde dehydrogenase family
JR441_19830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JR441_19840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JR441_19850	COG4585	Histidine kinase
JR441_19855	COG2197	response regulator
JR441_19860	COG2195	Cleaves the N-terminal amino acid of tripeptides
JR441_19870	COG4894	glucomannan catabolic process
JR441_19875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JR441_19880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JR441_19885	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_19890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JR441_19895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JR441_19900	COG2610	gluconate transmembrane transporter activity
JR441_19905	COG0500	methyltransferase
JR441_19910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JR441_19925	COG0693	protein deglycase activity
JR441_19925	COG0753	catalase activity
JR441_19930	COG2851	Citrate transporter
JR441_19935	COG2273	Hydrolase Family 16
JR441_19940	COG3711	transcriptional antiterminator
JR441_19950	COG2270	Major facilitator Superfamily
JR441_19955	COG0513	Belongs to the DEAD box helicase family
JR441_19960	COG3401	FG-GAP repeat protein
JR441_19960	COG2755	lipolytic protein G-D-S-L family
JR441_19985	COG0697	spore germination
JR441_19990	COG0589	response to stress
JR441_19995	COG2723	6-phospho-beta-galactosidase activity
JR441_20000	COG2190	(PTS) system
JR441_20000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JR441_20000	COG1263	PTS System
JR441_20010	COG5444	nuclease activity
JR441_20025	COG3507	Belongs to the glycosyl hydrolase 43 family
JR441_20035	COG2986	histidine ammonia-lyase
JR441_20040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JR441_20045	COG1228	amidohydrolase
JR441_20050	COG0010	Belongs to the arginase family
JR441_20055	COG0833	amino acid
JR441_20060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JR441_20065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JR441_20070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JR441_20075	COG2390	Transcriptional regulator
JR441_20085	COG3192	ethanolamine utilization protein
JR441_20090	COG2079	MmgE PrpD family protein
JR441_20095	COG1473	amidohydrolase
JR441_20100	COG1126	abc transporter atp-binding protein
JR441_20105	COG0765	amino acid transport
JR441_20110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JR441_20115	COG0456	acetyltransferase
JR441_20120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JR441_20130	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
JR441_20135	COG0561	phosphatase activity
JR441_20165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JR441_20170	COG5294	Protein conserved in bacteria
JR441_20175	COG0577	efflux transmembrane transporter activity
JR441_20180	COG1136	(ABC) transporter
JR441_20185	COG2205	protein histidine kinase activity
JR441_20190	COG0745	RESPONSE REGULATOR receiver
JR441_20195	COG0191	fructose-bisphosphate aldolase activity
JR441_20200	COG1082	Xylose isomerase domain protein TIM barrel
JR441_20205	COG1082	Xylose isomerase domain protein TIM barrel
JR441_20210	COG0673	inositol 2-dehydrogenase activity
JR441_20215	COG2814	Major facilitator Superfamily
JR441_20220	COG1082	Xylose isomerase domain protein TIM barrel
JR441_20225	COG3962	Belongs to the TPP enzyme family
JR441_20230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JR441_20240	COG1012	belongs to the aldehyde dehydrogenase family
JR441_20245	COG1349	DNA-binding transcription factor activity
JR441_20250	COG0667	Aldo Keto reductase
JR441_20265	COG2814	Major facilitator Superfamily
JR441_20270	COG0326	Molecular chaperone. Has ATPase activity
JR441_20280	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_20285	COG1309	transcriptional regulator
JR441_20290	COG1012	belongs to the aldehyde dehydrogenase family
JR441_20295	COG1714	RDD family
JR441_20300	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JR441_20310	COG1714	RDD family
JR441_20315	COG2311	Membrane
JR441_20320	COG1917	Cupin 2, conserved barrel domain protein
JR441_20325	COG1309	transcriptional regulator
JR441_20330	COG1028	Short-chain dehydrogenase reductase Sdr
JR441_20335	COG1846	Transcriptional regulator
JR441_20340	COG1380	Effector of murein hydrolase LrgA
JR441_20345	COG1346	cytolysis
JR441_20350	COG5039	Polysaccharide pyruvyl transferase
JR441_20355	COG1929	Belongs to the glycerate kinase type-1 family
JR441_20360	COG1802	Transcriptional regulator
JR441_20365	COG1070	Carbohydrate kinase
JR441_20370	COG2610	gluconate transmembrane transporter activity
JR441_20375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JR441_20380	COG0450	alkyl hydroperoxide reductase
JR441_20385	COG3634	alkyl hydroperoxide reductase activity
JR441_20395	COG2723	6-phospho-beta-galactosidase activity
JR441_20405	COG2188	Transcriptional regulator
JR441_20420	COG1131	(ABC) transporter
JR441_20425	COG1994	Peptidase M50
JR441_20430	COG0535	radical SAM domain protein
JR441_20440	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JR441_20460	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JR441_20475	COG1063	alcohol dehydrogenase
JR441_20495	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
JR441_20500	COG0456	acetyltransferase
JR441_20505	COG0457	Tetratricopeptide repeat
JR441_20515	COG0010	Belongs to the arginase family
JR441_20520	COG0833	amino acid
JR441_20525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JR441_20530	COG3829	transcription factor binding
JR441_20545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JR441_20550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JR441_20555	COG4853	Protein conserved in bacteria
JR441_20560	COG4863	YycH protein
JR441_20565	COG5002	protein histidine kinase activity
JR441_20570	COG0745	RESPONSE REGULATOR receiver
JR441_20600	COG0346	lactoylglutathione lyase activity
JR441_20605	COG0305	Participates in initiation and elongation during chromosome replication
JR441_20620	COG3093	addiction module antidote protein HigA
JR441_20625	COG2807	transmembrane transport
JR441_20630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JR441_20635	COG0359	binds to the 23S rRNA
JR441_20640	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JR441_20645	COG4241	membrane
JR441_20655	COG5577	PFAM Coat F domain
JR441_20660	COG1733	regulation of RNA biosynthetic process
JR441_20665	COG1227	inorganic diphosphatase activity
JR441_20680	COG2271	Major facilitator Superfamily
JR441_20685	COG4978	Transcriptional regulator
JR441_20685	COG0789	Transcriptional regulator
JR441_20695	COG4319	ketosteroid isomerase
JR441_20700	COG1357	PFAM Pentapeptide repeats (8 copies)
JR441_20705	COG2814	Major facilitator Superfamily
JR441_20710	COG0583	DNA-binding transcription factor activity
JR441_20715	COG2153	protein acetylation
JR441_20725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JR441_20730	COG1846	Transcriptional regulator
JR441_20735	COG2153	protein acetylation
JR441_20740	COG2364	Membrane
JR441_20745	COG0456	acetyltransferase
JR441_20750	COG2315	Protein conserved in bacteria
JR441_20755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JR441_20765	COG2814	Major facilitator Superfamily
JR441_20775	COG1331	Highly conserved protein containing a thioredoxin domain
JR441_20780	COG0789	Transcriptional regulator
JR441_20785	COG0697	spore germination
JR441_20790	COG1331	Highly conserved protein containing a thioredoxin domain
JR441_20795	COG1266	CAAX protease self-immunity
JR441_20800	COG2814	Major facilitator Superfamily
JR441_20800	COG0477	Major facilitator Superfamily
JR441_20805	COG0110	maltose O-acetyltransferase activity
JR441_20810	COG0346	lactoylglutathione lyase activity
JR441_20815	COG1609	Transcriptional regulator
JR441_20820	COG0708	Exodeoxyribonuclease III
JR441_20825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JR441_20830	COG0629	single-stranded DNA binding
JR441_20835	COG0360	Binds together with S18 to 16S ribosomal RNA
JR441_20840	COG0012	GTP binding
JR441_20845	COG0243	molybdopterin cofactor binding
JR441_20850	COG4481	Protein conserved in bacteria
JR441_20855	COG3949	Membrane
JR441_20865	COG1475	DNA binding
JR441_20870	COG1192	Involved in chromosome partitioning
JR441_20880	COG1475	DNA binding
JR441_20885	COG0357	Ribosomal RNA small subunit methyltransferase G
JR441_20890	COG0445	tRNA wobble uridine modification
JR441_20895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JR441_20900	COG1847	R3H domain protein
JR441_20905	COG0706	membrane insertase activity
JR441_20910	COG0594	ribonuclease P activity